PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28673560-3	2017	We show that the combination of the two pollutants (25nM TCDD and 10muM alpha-endosulfan) led to marked decreases in the amounts of both the mRNA (up to 90%) and protein (up to 60%) of ADH4 and CYP2E1.	Endosulfan	72-88	alcohol dehydrogenase 4 (class II), pi polypeptide	Homo sapiens	185-189
29765866-2	2018	Endosulfan exposure has been shown to elevate some inflammatory factors, such as nitric oxide (NO) and tumor necrosis factor (TNF), in animals or cultures of animal cells.	Endosulfan	0-10	tumor necrosis factor	Mus musculus	103-124
29765866-2	2018	Endosulfan exposure has been shown to elevate some inflammatory factors, such as nitric oxide (NO) and tumor necrosis factor (TNF), in animals or cultures of animal cells.	Endosulfan	0-10	tumor necrosis factor	Mus musculus	126-129
29765866-6	2018	In lipopolysaccharide (LPS)-activated cultures, both endosulfan isomers significantly reduced NO, but not TNF, at non-cytotoxic concentrations.	Endosulfan	53-63	tumor necrosis factor	Mus musculus	106-109
29765866-7	2018	These results suggest that the endosulfan isomers have some capacity to alter inflammatory responses differentially, particularly with IFN-gamma stimulation.	Endosulfan	31-41	interferon gamma	Mus musculus	135-144
28673560-0	2017	Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells.	Endosulfan	94-110	alcohol dehydrogenase 4 (class II), pi polypeptide	Homo sapiens	37-60
28673560-0	2017	Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells.	Endosulfan	94-110	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	65-71
29705383-5	2018	We observed the dramatic DNA damage using comet assay and the increase of micronucleus in 75 muM endosulfan-exposed cells.	Endosulfan	97-107	latexin	Homo sapiens	93-96
29705383-8	2018	Flow cytometric analysis showed that endosulfan at 50 and 75 muM induced cell cycle G1 arrest, a response attributed to down-regulation of CDK6 and up-regulation of p21.	Endosulfan	37-47	latexin	Homo sapiens	61-64
29705383-8	2018	Flow cytometric analysis showed that endosulfan at 50 and 75 muM induced cell cycle G1 arrest, a response attributed to down-regulation of CDK6 and up-regulation of p21.	Endosulfan	37-47	cyclin dependent kinase 6	Homo sapiens	139-143
29705383-8	2018	Flow cytometric analysis showed that endosulfan at 50 and 75 muM induced cell cycle G1 arrest, a response attributed to down-regulation of CDK6 and up-regulation of p21.	Endosulfan	37-47	H3 histone pseudogene 16	Homo sapiens	165-168
29705383-9	2018	We also observed that endosulfan at 50 and 75 muM induced a considerable percentage of cells to undergo apoptosis, as detected by Annexin-V binding assays.	Endosulfan	22-32	latexin	Homo sapiens	46-49
29705383-9	2018	We also observed that endosulfan at 50 and 75 muM induced a considerable percentage of cells to undergo apoptosis, as detected by Annexin-V binding assays.	Endosulfan	22-32	annexin A5	Homo sapiens	130-139
29705383-11	2018	These findings suggest that endosulfan caused DNA damage response throughATM-p53 signaling pathway, implicating the potential correlation between endosulfan and leukemia.	Endosulfan	28-38	tumor protein p53	Homo sapiens	77-80
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Endosulfan	206-222	protein arginine methyltransferase 5	Homo sapiens	72-108
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Endosulfan	206-222	protein arginine methyltransferase 5	Homo sapiens	110-115
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Endosulfan	206-222	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-148
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Endosulfan	206-222	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	150-154
29054638-10	2018	Moreover, overexpression of basal level of estrogen receptor alpha (ERalpha), suggests estrogenicity of alpha-endosulfan.	Endosulfan	104-120	estrogen receptor 1	Homo sapiens	43-66
29054638-10	2018	Moreover, overexpression of basal level of estrogen receptor alpha (ERalpha), suggests estrogenicity of alpha-endosulfan.	Endosulfan	104-120	estrogen receptor 1	Homo sapiens	68-75
28673560-3	2017	We show that the combination of the two pollutants (25nM TCDD and 10muM alpha-endosulfan) led to marked decreases in the amounts of both the mRNA (up to 90%) and protein (up to 60%) of ADH4 and CYP2E1.	Endosulfan	72-88	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	194-200
28559116-2	2017	We investigated whether implantation failures prompted by endosulfan are associated with aberrant ERalpha uterine expression and DNA methylation status during the pre-implantation period.	Endosulfan	58-68	estrogen receptor 1	Rattus norvegicus	98-105
28559116-10	2017	Both doses of endosulfan increased the expression of ERalpha and its transcript variants ERalpha-OS, ERalpha-O, ERalpha-OT and ERalpha-E1.	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	53-60
28559116-10	2017	Both doses of endosulfan increased the expression of ERalpha and its transcript variants ERalpha-OS, ERalpha-O, ERalpha-OT and ERalpha-E1.	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	89-96
28559116-10	2017	Both doses of endosulfan increased the expression of ERalpha and its transcript variants ERalpha-OS, ERalpha-O, ERalpha-OT and ERalpha-E1.	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	89-96
28559116-10	2017	Both doses of endosulfan increased the expression of ERalpha and its transcript variants ERalpha-OS, ERalpha-O, ERalpha-OT and ERalpha-E1.	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	89-96
28559116-10	2017	Both doses of endosulfan increased the expression of ERalpha and its transcript variants ERalpha-OS, ERalpha-O, ERalpha-OT and ERalpha-E1.	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	89-96
28273598-7	2017	Results showed that endosulfan induced DNA damage and activated DNA damage response signaling pathway (ATM/Chk2 and ATR/Chk1) and consequent cell cycle checkpoint.	Endosulfan	20-30	ATM serine/threonine kinase	Homo sapiens	103-106
28273598-7	2017	Results showed that endosulfan induced DNA damage and activated DNA damage response signaling pathway (ATM/Chk2 and ATR/Chk1) and consequent cell cycle checkpoint.	Endosulfan	20-30	checkpoint kinase 2	Homo sapiens	107-111
28273598-7	2017	Results showed that endosulfan induced DNA damage and activated DNA damage response signaling pathway (ATM/Chk2 and ATR/Chk1) and consequent cell cycle checkpoint.	Endosulfan	20-30	ATR serine/threonine kinase	Homo sapiens	116-119
28273598-7	2017	Results showed that endosulfan induced DNA damage and activated DNA damage response signaling pathway (ATM/Chk2 and ATR/Chk1) and consequent cell cycle checkpoint.	Endosulfan	20-30	checkpoint kinase 1	Homo sapiens	120-124
30090509-0	2017	Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans.	Endosulfan	40-50	Mitogen-activated protein kinase 15	Caenorhabditis elegans	17-21
30090509-8	2017	However, the apoptosis in the loss-of-function strains of JNK and p38 MAPK signaling pathways was completely or mildly suppressed under endosulfan stress.	Endosulfan	136-146	Mitogen-activated protein kinase 15	Caenorhabditis elegans	70-74
30090509-9	2017	The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	25-35	Stress-activated protein kinase jnk-1	Caenorhabditis elegans	67-72
30090509-9	2017	The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	25-35	Mitogen-activated protein kinase 15	Caenorhabditis elegans	77-81
30090509-9	2017	The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	25-35	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	83-88
30090509-9	2017	The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	25-35	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	100-105
30090509-9	2017	The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	25-35	Mitogen-activated protein kinase 15	Caenorhabditis elegans	110-114
30090509-11	2017	Our data provide evidence that endosulfan increases germ cell apoptosis, which is regulated by mitochondrial function, JNK and p38 MAPK cascades.	Endosulfan	31-41	Mitogen-activated protein kinase 15	Caenorhabditis elegans	131-135
28108160-8	2017	Endosulfan affected adherens junctions via E-cadherin and beta-catenin, and impaired gap junctions through downregulation of Cx43 in paracellular pathway.	Endosulfan	0-10	cadherin 1	Homo sapiens	43-53
28108160-8	2017	Endosulfan affected adherens junctions via E-cadherin and beta-catenin, and impaired gap junctions through downregulation of Cx43 in paracellular pathway.	Endosulfan	0-10	catenin beta 1	Homo sapiens	58-70
27814983-0	2017	Endosulfan induces autophagy and endothelial dysfunction via the AMPK/mTOR signaling pathway triggered by oxidative stress.	Endosulfan	0-10	mechanistic target of rapamycin kinase	Homo sapiens	70-74
27939630-5	2017	These results demonstrated that endosulfan inhibited proliferation through the Notch signaling pathway as a result of oxidative stress.	Endosulfan	32-42	notch receptor 1	Homo sapiens	79-84
30090493-8	2017	The results of this research suggested that endosulfan could lead to E2F-1-induced apoptosis of spermatogenic cells by activating the negative regulation factors of the cell cycle, and endosulfan might cause apoptosis by death receptor pathway, causing oxidative stress.	Endosulfan	44-54	E2F transcription factor 1	Rattus norvegicus	69-74
28161397-0	2017	miR-22 contributes to endosulfan-induced endothelial dysfunction by targeting SRF in HUVECs.	Endosulfan	22-32	microRNA 22	Homo sapiens	0-6
28161397-0	2017	miR-22 contributes to endosulfan-induced endothelial dysfunction by targeting SRF in HUVECs.	Endosulfan	22-32	serum response factor	Homo sapiens	78-81
28161397-4	2017	In the present study, we investigated the involvement of miR-22 in endosulfan-induced endothelial dysfunction.	Endosulfan	67-77	microRNA 22	Homo sapiens	57-63
28161397-11	2017	Taken together, these findings will shed light on the role and mechanism of miR-22 in endosulfan-induced endothelial dysfunction via SRF in HUVECs.	Endosulfan	86-96	microRNA 22	Homo sapiens	76-82
27939630-0	2017	Endosulfan inhibits proliferation through the Notch signaling pathway in human umbilical vein endothelial cells.	Endosulfan	0-10	notch receptor 1	Homo sapiens	46-51
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	delta like canonical Notch ligand 4	Homo sapiens	138-142
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	notch receptor 1	Homo sapiens	144-150
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	notch receptor 1	Homo sapiens	160-166
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	jagged canonical Notch ligand 1	Homo sapiens	168-175
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	notch receptor 4	Homo sapiens	177-183
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	hes family bHLH transcription factor 1	Homo sapiens	185-189
27939630-3	2017	We also found that endosulfan can damage microfilaments, microtubules, and nuclei; arrest mitosis; remarkably increase the expressions of Dll4, Notch1, Cleaved-Notch1, Jagged1, Notch4, Hes1, and p21; and significantly induce ROS and malondialdehyde production in HUVECs.	Endosulfan	19-29	H3 histone pseudogene 16	Homo sapiens	195-198
27709431-6	2017	In addition, endosulfan promoted the increases of ROS, IL-1alpha, and IL-33 levels while antioxidant N-acetyl-L-cysteine (NAC) effectively attenuated the cytotoxicity from endosulfan.	Endosulfan	13-23	interleukin 1 alpha	Homo sapiens	55-64
27709431-6	2017	In addition, endosulfan promoted the increases of ROS, IL-1alpha, and IL-33 levels while antioxidant N-acetyl-L-cysteine (NAC) effectively attenuated the cytotoxicity from endosulfan.	Endosulfan	13-23	interleukin 33	Homo sapiens	70-75
27709431-6	2017	In addition, endosulfan promoted the increases of ROS, IL-1alpha, and IL-33 levels while antioxidant N-acetyl-L-cysteine (NAC) effectively attenuated the cytotoxicity from endosulfan.	Endosulfan	172-182	X-linked Kx blood group	Homo sapiens	122-125
27709431-7	2017	Taken together, these results have demonstrated that endosulfan induces the apoptosis and necroptosis of HUVECs, where the RIPK pathway plays a pro-necroptotic role and NAC plays an anti-necroptotic role.	Endosulfan	53-63	X-linked Kx blood group	Homo sapiens	169-172
27814983-9	2017	Our findings demonstrated that endosulfan could induce oxidative stress and mitochondria injury, activate autophagy, induce inflammatory response, and eventually lead to endothelial dysfunction via the AMPK/mTOR pathway.	Endosulfan	31-41	mechanistic target of rapamycin kinase	Homo sapiens	207-211
27720795-7	2016	Similar to the observations in the chronic 14-day exposure studies, MSR was inhibited by acute 30-min exposure to methylmercury, chlorpyrifos, and alpha-cypermethrin [LOECs: 1muM, 10muM, and 1muM, respectively], whereas endosulfan increased MSR [LOEC: 0.3muM].	Endosulfan	220-230	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	68-71
26242398-0	2016	HSP27 modulates survival signaling in endosulfan-exposed human peripheral blood mononuclear cells treated with curcumin.	Endosulfan	38-48	heat shock protein family B (small) member 1	Homo sapiens	0-5
27494533-0	2016	Chronic exposure to endosulfan induces inflammation in murine colon via beta-catenin expression and IL-6 production.	Endosulfan	20-30	catenin (cadherin associated protein), beta 1	Mus musculus	72-84
27494533-0	2016	Chronic exposure to endosulfan induces inflammation in murine colon via beta-catenin expression and IL-6 production.	Endosulfan	20-30	interleukin 6	Mus musculus	100-104
25647812-4	2016	The results showed that endosulfan significantly improved the expressions of cytochrome c and B-cell lymphoma 2 (Bcl-2)-associated X protein and increased the activities of caspases 9 and 3 as well as the downregulation of the expression of Bcl-2 in GC-1 spg cells.	Endosulfan	24-34	B cell leukemia/lymphoma 2	Mus musculus	94-111
25647812-4	2016	The results showed that endosulfan significantly improved the expressions of cytochrome c and B-cell lymphoma 2 (Bcl-2)-associated X protein and increased the activities of caspases 9 and 3 as well as the downregulation of the expression of Bcl-2 in GC-1 spg cells.	Endosulfan	24-34	B cell leukemia/lymphoma 2	Mus musculus	113-118
25647812-4	2016	The results showed that endosulfan significantly improved the expressions of cytochrome c and B-cell lymphoma 2 (Bcl-2)-associated X protein and increased the activities of caspases 9 and 3 as well as the downregulation of the expression of Bcl-2 in GC-1 spg cells.	Endosulfan	24-34	caspase 9	Mus musculus	173-189
25647812-4	2016	The results showed that endosulfan significantly improved the expressions of cytochrome c and B-cell lymphoma 2 (Bcl-2)-associated X protein and increased the activities of caspases 9 and 3 as well as the downregulation of the expression of Bcl-2 in GC-1 spg cells.	Endosulfan	24-34	B cell leukemia/lymphoma 2	Mus musculus	241-246
26714676-6	2016	Flow cytometric analysis showed that endosulfan at 60 muM induced G1 cell cycle arrest, a response attributed to down-regulation of CDK6 and pRb dephosphorylation.	Endosulfan	37-47	latexin	Homo sapiens	54-57
26714676-6	2016	Flow cytometric analysis showed that endosulfan at 60 muM induced G1 cell cycle arrest, a response attributed to down-regulation of CDK6 and pRb dephosphorylation.	Endosulfan	37-47	cyclin dependent kinase 6	Homo sapiens	132-136
26714676-6	2016	Flow cytometric analysis showed that endosulfan at 60 muM induced G1 cell cycle arrest, a response attributed to down-regulation of CDK6 and pRb dephosphorylation.	Endosulfan	37-47	RB transcriptional corepressor 1	Homo sapiens	141-144
26714676-7	2016	We observed that endosulfan at 40 and 60 muM induced a considerable percentage of cells to undergo apoptosis, as detected by Annexin-V binding assays.	Endosulfan	17-27	latexin	Homo sapiens	41-44
26714676-7	2016	We observed that endosulfan at 40 and 60 muM induced a considerable percentage of cells to undergo apoptosis, as detected by Annexin-V binding assays.	Endosulfan	17-27	annexin A5	Homo sapiens	125-134
27460030-5	2016	Results show that endosulfan caused the reductions in sperm concentration and motility rate, which resulted into an increased in sperm abnormality rate; further, endosulfan induced downregulation of spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor (Sohlh1) which controls the switch on meiosis in mammals, as well cyclin A1, cyclin-dependent kinases 1 (CDK1), and cyclin-dependent kinases 2 (CDK2).	Endosulfan	18-28	spermatogenesis and oogenesis specific basic helix-loop-helix 1	Rattus norvegicus	284-290
27460030-5	2016	Results show that endosulfan caused the reductions in sperm concentration and motility rate, which resulted into an increased in sperm abnormality rate; further, endosulfan induced downregulation of spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor (Sohlh1) which controls the switch on meiosis in mammals, as well cyclin A1, cyclin-dependent kinases 1 (CDK1), and cyclin-dependent kinases 2 (CDK2).	Endosulfan	18-28	cyclin A1	Rattus norvegicus	349-358
27460030-5	2016	Results show that endosulfan caused the reductions in sperm concentration and motility rate, which resulted into an increased in sperm abnormality rate; further, endosulfan induced downregulation of spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor (Sohlh1) which controls the switch on meiosis in mammals, as well cyclin A1, cyclin-dependent kinases 1 (CDK1), and cyclin-dependent kinases 2 (CDK2).	Endosulfan	18-28	cyclin-dependent kinase 1	Rattus norvegicus	388-392
27460030-5	2016	Results show that endosulfan caused the reductions in sperm concentration and motility rate, which resulted into an increased in sperm abnormality rate; further, endosulfan induced downregulation of spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor (Sohlh1) which controls the switch on meiosis in mammals, as well cyclin A1, cyclin-dependent kinases 1 (CDK1), and cyclin-dependent kinases 2 (CDK2).	Endosulfan	18-28	cyclin dependent kinase 2	Rattus norvegicus	427-431
27460030-8	2016	The results suggested that endosulfan could inhibit the start of meiosis by downregulating the expression of Sohlh1 and induce G2/M phase arrest of cell cycle by decreasing the expression of cyclin A1, CDK1, and CDK2 via oxidative damage, which inhibits the meiosis process, and therefore decrease the amount of sperm.	Endosulfan	27-37	spermatogenesis and oogenesis specific basic helix-loop-helix 1	Rattus norvegicus	109-115
27460030-8	2016	The results suggested that endosulfan could inhibit the start of meiosis by downregulating the expression of Sohlh1 and induce G2/M phase arrest of cell cycle by decreasing the expression of cyclin A1, CDK1, and CDK2 via oxidative damage, which inhibits the meiosis process, and therefore decrease the amount of sperm.	Endosulfan	27-37	cyclin A1	Rattus norvegicus	191-200
27460030-8	2016	The results suggested that endosulfan could inhibit the start of meiosis by downregulating the expression of Sohlh1 and induce G2/M phase arrest of cell cycle by decreasing the expression of cyclin A1, CDK1, and CDK2 via oxidative damage, which inhibits the meiosis process, and therefore decrease the amount of sperm.	Endosulfan	27-37	cyclin-dependent kinase 1	Rattus norvegicus	202-206
27460030-8	2016	The results suggested that endosulfan could inhibit the start of meiosis by downregulating the expression of Sohlh1 and induce G2/M phase arrest of cell cycle by decreasing the expression of cyclin A1, CDK1, and CDK2 via oxidative damage, which inhibits the meiosis process, and therefore decrease the amount of sperm.	Endosulfan	27-37	cyclin dependent kinase 2	Rattus norvegicus	212-216
26242398-7	2016	The present study indicates that the beneficial effect of curcumin on endosulfan-induced cytotoxicity is related to the induced synthesis of HSP27, emphasizing its antioxidant and therapeutic potential as well as underscoring the mechanism of pesticide-induced toxicity at cellular level.	Endosulfan	70-80	heat shock protein family B (small) member 1	Homo sapiens	141-146
26905428-4	2016	Methyl-parathion, carbofuran, and endosulfan induced Trp fluorescence quenching and release of cytochrome c when incubated with the mitochondria, except fenvalarate.	Endosulfan	34-44	cytochrome c, somatic	Homo sapiens	95-107
26722802-3	2016	In the present study, the effect of sub-lethal concentration of endosulfan (3 muM) on human neuroblastoma cells (SH-SY5Y) was investigated using genomic and proteomic approaches.	Endosulfan	64-74	latexin	Homo sapiens	78-81
26979317-3	2016	A strong inhibition on the radiolytic degradation of endosulfan was observed in the presence of NO3 (-), NO2 (-), and SO3 (2-).	Endosulfan	53-63	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
26492975-10	2016	These results revealed endosulfan could cause toxicity in the rabbit spleen, characterized by depletion of lymphocytes, inflammation, necrosis and hemorrhage, and that this toxicity could begin to be mitigated by Vit C co-treatment.	Endosulfan	23-33	vitrin	Oryctolagus cuniculus	213-216
27092634-4	2016	Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit.	Endosulfan	17-27	tumor necrosis factor	Rattus norvegicus	141-150
27092634-4	2016	Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit.	Endosulfan	17-27	interleukin 1 beta	Rattus norvegicus	156-173
27092634-4	2016	Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit.	Endosulfan	17-27	interleukin 1 beta	Rattus norvegicus	175-183
27092634-4	2016	Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit.	Endosulfan	17-27	synaptotagmin 1	Rattus norvegicus	305-308
26911934-1	2016	Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and beta-catenin during uterine development leading to the failure of uterine functional differentiation during implantation.	Endosulfan	35-45	Wnt family member 7A	Rattus norvegicus	76-81
26911934-1	2016	Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and beta-catenin during uterine development leading to the failure of uterine functional differentiation during implantation.	Endosulfan	35-45	catenin beta 1	Rattus norvegicus	86-98
25077688-4	2016	It is likely that TP relieve the reproductive toxicity by reversing the endosulfan-induced decreases in testosterone secretion and AR expression that resulted from the alteration of Leydig cell function.	Endosulfan	72-82	androgen receptor	Mus musculus	131-133
30090376-4	2016	We performed DNA microarray analysis to analyze gene expression profiles in human endothelial cells exposed to 20, 40 and 60 muM endosulfan in combination with an endothelial phenotype.	Endosulfan	129-139	latexin	Homo sapiens	125-128
26877836-0	2015	Endosulfan Induces CYP1A1 Expression Mediated through Aryl Hydrocarbon Receptor Signal Transduction by Protein Kinase C. CYP1A1 is a phase I xenobiotic-metabolizing enzyme whose expression is mainly driven by AhR.	Endosulfan	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-25
26493407-11	2016	High pesticide levels, particularly alpha-endosulfan and HCE, were associated with an increase of SHBG (P < 0.05) and E2 (P < 0.01) and a decrease of fT (P < 0.05) and AI (P < 0.01).	Endosulfan	36-52	sex hormone binding globulin	Homo sapiens	98-102
26877836-0	2015	Endosulfan Induces CYP1A1 Expression Mediated through Aryl Hydrocarbon Receptor Signal Transduction by Protein Kinase C. CYP1A1 is a phase I xenobiotic-metabolizing enzyme whose expression is mainly driven by AhR.	Endosulfan	0-10	aryl hydrocarbon receptor	Homo sapiens	54-79
26877836-0	2015	Endosulfan Induces CYP1A1 Expression Mediated through Aryl Hydrocarbon Receptor Signal Transduction by Protein Kinase C. CYP1A1 is a phase I xenobiotic-metabolizing enzyme whose expression is mainly driven by AhR.	Endosulfan	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-127
26877836-0	2015	Endosulfan Induces CYP1A1 Expression Mediated through Aryl Hydrocarbon Receptor Signal Transduction by Protein Kinase C. CYP1A1 is a phase I xenobiotic-metabolizing enzyme whose expression is mainly driven by AhR.	Endosulfan	0-10	aryl hydrocarbon receptor	Homo sapiens	209-212
26877836-2	2015	In this study, we investigated the effect of endosulfan on CYP1A1 expression and regulation.	Endosulfan	45-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
26877836-5	2015	CH-223191, an AhR antagonist, blocked the endosulfan-induced increase in CYP1A1 mRNA and protein expression.	Endosulfan	42-52	aryl hydrocarbon receptor	Homo sapiens	14-17
26877836-5	2015	CH-223191, an AhR antagonist, blocked the endosulfan-induced increase in CYP1A1 mRNA and protein expression.	Endosulfan	42-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
26877836-7	2015	Furthermore, endosulfan enhanced the phosphorylation of calcium calmodulin (CaM)-dependent protein kinase (CaMK) and protein kinase C (PKC).	Endosulfan	13-23	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	107-111
26877836-8	2015	In conclusion, endosulfan-induced up-regulation of CYP1A1 is associated with AhR activation, which may be mediated by PKC-dependent pathways.	Endosulfan	15-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57
26877836-8	2015	In conclusion, endosulfan-induced up-regulation of CYP1A1 is associated with AhR activation, which may be mediated by PKC-dependent pathways.	Endosulfan	15-25	aryl hydrocarbon receptor	Homo sapiens	77-80
25199686-8	2015	Endosulfan-induced Akt/MAPK pathways and COX-2 expression were attenuated by DPI, a specific NOX inhibitor, and the ROS scavenger N-acetylcysteine.	Endosulfan	0-10	thymoma viral proto-oncogene 1	Mus musculus	19-22
25199686-8	2015	Endosulfan-induced Akt/MAPK pathways and COX-2 expression were attenuated by DPI, a specific NOX inhibitor, and the ROS scavenger N-acetylcysteine.	Endosulfan	0-10	cytochrome c oxidase II, mitochondrial	Mus musculus	41-46
25199686-0	2015	Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways.	Endosulfan	0-10	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
25199686-9	2015	These results demonstrate that endosulfan induces COX-2 expression via NADPH oxidase, ROS, and Akt/MAPK pathways.	Endosulfan	31-41	cytochrome c oxidase II, mitochondrial	Mus musculus	50-55
25199686-0	2015	Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways.	Endosulfan	0-10	thymoma viral proto-oncogene 1	Mus musculus	77-80
25199686-9	2015	These results demonstrate that endosulfan induces COX-2 expression via NADPH oxidase, ROS, and Akt/MAPK pathways.	Endosulfan	31-41	thymoma viral proto-oncogene 1	Mus musculus	95-98
25199686-2	2015	Recently, endosulfan was shown to have an effect on inflammatory pathways, but its influence on cyclooxygenase-2(COX-2) expression is unclear.	Endosulfan	10-20	cytochrome c oxidase II, mitochondrial	Mus musculus	113-118
25199686-4	2015	Endosulfan significantly induced COX-2 protein and mRNA levels, as well as COX-2 promoter-driven luciferase activity and the production of prostaglandin E2, a major COX-2 metabolite.	Endosulfan	0-10	cytochrome c oxidase II, mitochondrial	Mus musculus	33-38
26615145-4	2015	Furthermore, downregulation of PHLDA gene, upregulation of ACIN1 protein and caspase-3 activation in exposed cells indicated that endosulfan can trigger apoptotic cascade in hepatocellular carcinoma cells.	Endosulfan	130-140	apoptotic chromatin condensation inducer 1	Homo sapiens	59-64
25199686-6	2015	Moreover, Akt and mitogen-activated protein kinases (MAPK) were significantly activated by endosulfan.	Endosulfan	91-101	thymoma viral proto-oncogene 1	Mus musculus	10-13
25199686-7	2015	Moreover, endosulfan increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2, and NOX3.	Endosulfan	10-20	cytochrome b-245, beta polypeptide	Mus musculus	112-116
25199686-7	2015	Moreover, endosulfan increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2, and NOX3.	Endosulfan	10-20	NADPH oxidase 3	Mus musculus	122-126
26615145-4	2015	Furthermore, downregulation of PHLDA gene, upregulation of ACIN1 protein and caspase-3 activation in exposed cells indicated that endosulfan can trigger apoptotic cascade in hepatocellular carcinoma cells.	Endosulfan	130-140	caspase 3	Homo sapiens	77-86
26028348-4	2015	The results showed that endosulfan significantly decreased the prothrombin time (PT) and upregulated the activated coagulation factors VIIa, Xa, and XIIIa; thrombin-antithrombin complex (TAT); and P-selectin.	Endosulfan	24-34	selectin P	Rattus norvegicus	197-207
26028348-5	2015	Plasma levels of tissue factor (TF) and malondialdehyde (MDA) were increased in the endosulfan groups.	Endosulfan	84-94	coagulation factor III, tissue factor	Rattus norvegicus	17-30
26028348-5	2015	Plasma levels of tissue factor (TF) and malondialdehyde (MDA) were increased in the endosulfan groups.	Endosulfan	84-94	coagulation factor III, tissue factor	Rattus norvegicus	32-34
26028348-9	2015	In summary, our results suggest that endosulfan damages endothelial cells via oxidative stress and the inflammatory response, leading to the release of TF and vWF into the blood.	Endosulfan	37-47	coagulation factor III, tissue factor	Rattus norvegicus	152-154
26028348-9	2015	In summary, our results suggest that endosulfan damages endothelial cells via oxidative stress and the inflammatory response, leading to the release of TF and vWF into the blood.	Endosulfan	37-47	von Willebrand factor	Rattus norvegicus	159-162
26159488-10	2015	At low concentrations (0.2 nM TCDD and 1 muM alpha-endosulfan), the POPs still had significant effects and the levels of expression of the corresponding proteins were found to be affected for some genes.	Endosulfan	45-61	latexin	Homo sapiens	41-44
25721524-3	2015	Gavages of endosulfan into rats at the dose of 2 mg/kg induced oxidative stress in this organelle since it provokes a significant reduction of catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) level.	Endosulfan	11-21	catalase	Rattus norvegicus	143-151
26008642-2	2015	In addition, the presence of beta-endosulfan, endosulfan suphate, cypermethrin, cyhalothrin, fenvalerate, deltamethrin, malathion, profenofos, and ethion was reported in milk samples.	Endosulfan	29-44	Weaning weight-maternal milk	Bos taurus	170-174
25721524-3	2015	Gavages of endosulfan into rats at the dose of 2 mg/kg induced oxidative stress in this organelle since it provokes a significant reduction of catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) level.	Endosulfan	11-21	catalase	Rattus norvegicus	153-156
25666835-5	2015	The mitochondria membrane potential was disrupted by endosulfan, leading to a significant increase of germ cell apoptosis in mev-1(kn-1) mutant.	Endosulfan	53-63	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	125-130
25666835-6	2015	However, the apoptotic effects of endosulfan were blocked in mutants of cep-1(w40), egl-1(n487), and hus-1(op241), indicating conserved genotoxic response genes played an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	34-44	Transcription factor cep-1	Caenorhabditis elegans	72-77
25666835-6	2015	However, the apoptotic effects of endosulfan were blocked in mutants of cep-1(w40), egl-1(n487), and hus-1(op241), indicating conserved genotoxic response genes played an essential role in endosulfan-induced germ cell apoptosis.	Endosulfan	34-44	Checkpoint protein	Caenorhabditis elegans	101-106
25666835-7	2015	Furthermore, exposure to endosulfan induced the accumulation of HUS-1::GFP foci and the germ cell cycle arrest.	Endosulfan	25-35	HUS1 checkpoint clamp component	Homo sapiens	64-69
24832206-0	2014	Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.	Endosulfan	16-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60
25612189-8	2015	Our data provide clear evidence that the DNA-checkpoint gene hus-1 has an essential role in endosulfan-induced reproductive dysfunction and that alpha-endosulfan exhibited the highest reproductive toxicity among the different forms of endosulfan.	Endosulfan	92-102	Checkpoint protein	Caenorhabditis elegans	61-66
25458686-2	2014	The stereo specific metabolic activity of human CYP-2B6 (cytochrome P450) on endosulfan has been well demonstrated.	Endosulfan	77-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	48-55
25458686-4	2014	The functional similarity was studied at organism level by batch-scale studies and it was proved that B. megaterium could metabolize endosulfan to endosulfan sulfate, as CYP-2B6 does in human system.	Endosulfan	133-143	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	170-177
25486513-5	2015	On GD5, DES and endosulfan did not change the serum levels of 17beta-estradiol (E2) and progesterone (P); the endometrial proliferation decreased, which was associated with silencing of Hoxa10 in the Endo600-treated rats.	Endosulfan	16-26	homeobox A10	Rattus norvegicus	186-192
25486513-6	2015	Both doses of endosulfan increased the progesterone receptor (PR) expression, whereas the higher dose led additionally to an increase in estrogen receptor alpha (ERalpha).	Endosulfan	14-24	progesterone receptor	Rattus norvegicus	39-60
25486513-6	2015	Both doses of endosulfan increased the progesterone receptor (PR) expression, whereas the higher dose led additionally to an increase in estrogen receptor alpha (ERalpha).	Endosulfan	14-24	progesterone receptor	Rattus norvegicus	62-64
25486513-6	2015	Both doses of endosulfan increased the progesterone receptor (PR) expression, whereas the higher dose led additionally to an increase in estrogen receptor alpha (ERalpha).	Endosulfan	14-24	estrogen receptor 1	Rattus norvegicus	162-169
25737830-0	2015	Isolation and identification of endosulfan-degrading bacteria and evaluation of their bioremediation in kor river, iran.	Endosulfan	32-42	opioid receptor kappa 1	Homo sapiens	104-107
25737830-3	2015	The aim of this study was to isolate and identify endosulfan-degrading bacteria from the Kor River and evaluate the possibility of applying bioremediation in reducing environmental pollution in the desired region.	Endosulfan	50-60	opioid receptor kappa 1	Homo sapiens	89-92
24832206-0	2014	Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.	Endosulfan	16-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	65-71
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Endosulfan	58-68	nuclear receptor subfamily 1 group I member 3	Homo sapiens	158-161
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Endosulfan	58-68	nuclear receptor subfamily 1 group I member 2	Homo sapiens	167-170
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Endosulfan	58-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Endosulfan	58-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	192-198
24832206-7	2014	Endosulfan exerted a direct reversible inhibition of CYP3A4 activity that was confirmed in human liver microsomes.	Endosulfan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	53-59
24832206-11	2014	Altogether, our data suggest that CAR and PXR activators endosulfan and methoxychlor can interact together and with other exogenous substrates in human hepatocytes.	Endosulfan	57-67	nuclear receptor subfamily 1 group I member 3	Homo sapiens	34-37
24832206-11	2014	Altogether, our data suggest that CAR and PXR activators endosulfan and methoxychlor can interact together and with other exogenous substrates in human hepatocytes.	Endosulfan	57-67	nuclear receptor subfamily 1 group I member 2	Homo sapiens	42-45
24532542-0	2014	Determination of endosulfan isomers and their metabolites in tap water and commercial samples using microextraction by packed sorbent and GC-MS. A simple, rapid, accurate and sensitive method using microextraction by packed sorbent (MEPS) followed by GC-MS has been pursued for the determination of organochlorine insecticide endosulfan isomers (alpha and beta) and their metabolites (ether, lactone and sulfate).	Endosulfan	17-27	nuclear RNA export factor 1	Homo sapiens	61-64
24657320-0	2014	Endosulfan decreases cytotoxic activity of nonspecific cytotoxic cells and expression of granzyme gene in Oreochromis niloticus.	Endosulfan	0-10	uncharacterized protein LOC100695218	Oreochromis niloticus	89-97
24657320-6	2014	Additionally, the exposure to endosulfan tended to increase the expression of NCCRP-1, which is involved in NCC antigen recognition and signaling.	Endosulfan	30-40	F-box only protein 50	Oreochromis niloticus	78-85
24657320-8	2014	In summary, the acute exposure of Nile tilapia to sublethal concentration of endosulfan induces alteration in function of NCC: significant decrease of cytotoxic activity and a tendency to lower granzyme expression, severe enough to compromise the immunity of this species.	Endosulfan	77-87	uncharacterized protein LOC100695218	Oreochromis niloticus	194-202
24262488-7	2014	Oxidative stress was induced by endosulfan treatment as evidenced by increased H2O2 level and LPO and decreased the antioxidant enzymes SOD, CAT and GPx activities and GSH content.	Endosulfan	32-42	lactoperoxidase	Rattus norvegicus	94-97
24216264-9	2014	Blood levels of HCH, endosulfan and total pesticides were significantly higher in CKD patients and negatively correlated with eGFR.	Endosulfan	21-31	epidermal growth factor receptor	Homo sapiens	126-130
24262488-7	2014	Oxidative stress was induced by endosulfan treatment as evidenced by increased H2O2 level and LPO and decreased the antioxidant enzymes SOD, CAT and GPx activities and GSH content.	Endosulfan	32-42	catalase	Rattus norvegicus	141-144
24555676-8	2014	Data demonstrated a significant relation between AChE activity inhibition and presence of endosulfan II, gamma-HCH, copper, lead, and 4,4-DDE, as well as between AChE and GST activity at different sites.	Endosulfan	90-103	acetylcholinesterase	Crassostrea gigas	49-53
24484539-6	2014	The ligand-CYP3A5 interaction energies (U values) for vincristine, R- and S-verapamil, and beta-endosulfan were considerably lower than the corresponding ligand-CYP3A4 interaction energies; these substrates also had lower reported Michaelis constants (km) for CYP3A5 than for CYP3A4.	Endosulfan	91-106	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	11-17
24484539-6	2014	The ligand-CYP3A5 interaction energies (U values) for vincristine, R- and S-verapamil, and beta-endosulfan were considerably lower than the corresponding ligand-CYP3A4 interaction energies; these substrates also had lower reported Michaelis constants (km) for CYP3A5 than for CYP3A4.	Endosulfan	91-106	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	260-266
24484539-6	2014	The ligand-CYP3A5 interaction energies (U values) for vincristine, R- and S-verapamil, and beta-endosulfan were considerably lower than the corresponding ligand-CYP3A4 interaction energies; these substrates also had lower reported Michaelis constants (km) for CYP3A5 than for CYP3A4.	Endosulfan	91-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	276-282
24484539-7	2014	Despite higher CYP3A5 km values for alpha-endosulfan and estradiol, the CYP3A5 U value for estradiol was lower than that for CYP3A4.	Endosulfan	36-52	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	15-21
23384675-11	2013	Endosulfan and kepone (group 3) weakly activated ERalpha.	Endosulfan	0-10	estrogen receptor 1	Homo sapiens	49-56
24068650-0	2013	Toxicity of endosulfan to tadpoles of Fejervarya spp.	Endosulfan	12-22	histocompatibility minor 13	Homo sapiens	49-52
23523001-0	2013	The effects of endosulfan on cytochrome P450 enzymes and glutathione S-transferases in zebrafish (Danio rerio) livers.	Endosulfan	15-25	cytochrome P450, family 2, subfamily AA, polypeptide 1	Danio rerio	29-44
23523001-2	2013	The present study was performed to investigate the effect of endosulfan on liver microsomal cytochrome P450 (CYP) enzymes and glutathione S-transferases (GST) in zebrafish.	Endosulfan	61-71	cytochrome P450, family 2, subfamily AA, polypeptide 1	Danio rerio	92-107
23523001-2	2013	The present study was performed to investigate the effect of endosulfan on liver microsomal cytochrome P450 (CYP) enzymes and glutathione S-transferases (GST) in zebrafish.	Endosulfan	61-71	cytochrome P450, family 2, subfamily AA, polypeptide 1	Danio rerio	109-112
23523001-4	2013	After exposure to endosulfan, the content of CYP increased and later gradually fell back to control level in most sampling time intervals.	Endosulfan	18-28	cytochrome P450, family 2, subfamily AA, polypeptide 1	Danio rerio	45-48
23523001-9	2013	Overall, the present results demonstrate the toxicity at low doses of endosulfan and indicated marked induction of CYP and GST enzymes in zebrafish liver.	Endosulfan	70-80	cytochrome P450, family 2, subfamily AA, polypeptide 1	Danio rerio	115-118
21340455-1	2011	The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats.	Endosulfan	50-60	butyrylcholinesterase	Rattus norvegicus	68-82
22535316-7	2012	Low endosulfan concentrations (0.01 mug L-1) induced a slight increase of SOD and CAT activity, which kept ROS in a stable level.	Endosulfan	4-14	catalase	Danio rerio	82-85
22535316-8	2012	High endosulfan concentration (10 mug L-1) induced excessive ROS production which exceeded the capacity of the cellular antioxidants and exhausted the enzyme including CAT and SOD.	Endosulfan	5-15	catalase	Danio rerio	168-171
22720419-2	2012	An ozone dosage of 57 mg min(-1) was found to be optimal for the degradation of both endosulfan (89%) and lindane (43%).	Endosulfan	85-95	CD59 molecule (CD59 blood group)	Homo sapiens	25-31
22146149-3	2012	Recent studies demonstrated that oxidative stress induced by endosulfan is involved in its toxicity and accumulating evidence suggests that endosulfan can modulate the activities of stress-responsive signal transduction pathways including extracellular signal regulated kinases (ERK) 1/2.	Endosulfan	140-150	mitogen-activated protein kinase 3	Homo sapiens	239-287
22146149-5	2012	In this report, we show that treatment of HepG2 cells with endosulfan significantly increased oxidative stress-responsive transcription via AP-1 activation.	Endosulfan	59-69	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
22146149-7	2012	Exposure to endosulfan resulted in a significant increase in the activities of MAPKs, ERK1/2 and p38.	Endosulfan	12-22	mitogen-activated protein kinase 3	Homo sapiens	86-92
22146149-7	2012	Exposure to endosulfan resulted in a significant increase in the activities of MAPKs, ERK1/2 and p38.	Endosulfan	12-22	mitogen-activated protein kinase 1	Homo sapiens	97-100
22146149-8	2012	Endosulfan-induced increases in enzymatic activities of these MAPKs were consistent with MAPK phosphorylation.	Endosulfan	0-10	mitogen-activated protein kinase 3	Homo sapiens	62-66
22146149-9	2012	Endosulfan exposure also caused an increase in c-Jun phosphorylation.	Endosulfan	0-10	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-52
22146149-10	2012	These results suggest a model for endosulfan toxicity in which endosulfan increases ERK1/2 and p38 activities and these activated MAPKs then increase c-Jun phosphorylation.	Endosulfan	34-44	mitogen-activated protein kinase 3	Homo sapiens	84-90
22146149-10	2012	These results suggest a model for endosulfan toxicity in which endosulfan increases ERK1/2 and p38 activities and these activated MAPKs then increase c-Jun phosphorylation.	Endosulfan	34-44	mitogen-activated protein kinase 1	Homo sapiens	95-98
22146149-10	2012	These results suggest a model for endosulfan toxicity in which endosulfan increases ERK1/2 and p38 activities and these activated MAPKs then increase c-Jun phosphorylation.	Endosulfan	34-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-155
22591281-5	2012	The messenger RNA (mRNA) levels of interleukin (IL)-2 and IL-6 in the endosulfan-treated group were significantly higher than that of the control group.	Endosulfan	70-80	interleukin 2	Mus musculus	35-53
22591281-5	2012	The messenger RNA (mRNA) levels of interleukin (IL)-2 and IL-6 in the endosulfan-treated group were significantly higher than that of the control group.	Endosulfan	70-80	interleukin 6	Mus musculus	58-62
22591281-6	2012	The mRNA levels of IL-6 in the experimental group were lower than that of the endosulfan-treated group, whereas the mRNA levels of IL-2 and interferon-gamma had no significant difference between the 2 groups.	Endosulfan	78-88	interleukin 6	Mus musculus	19-23
23208437-0	2012	Crry receptor and oxidative stress involved in erythrocyte immune toxicity of mice caused by endosulfan and protective effects of vitamin E.	Endosulfan	93-103	complement component (3b/4b) receptor 1-like	Mus musculus	0-4
23208437-8	2012	Vitamin E could stabilize the expression of Crry receptor by inhibiting oxidative stress, and thereby reverse the decrease of erythrocyte immunity caused by endosulfan.	Endosulfan	157-167	complement component (3b/4b) receptor 1-like	Mus musculus	44-48
21842492-2	2011	In the present study, we explored the potential endocrine-disrupting risk of beta-endosulfan by investigating its effect on the growth, reproduction, plasma vitellogenin, and organ histology of adult zebrafish.	Endosulfan	77-92	vitellogenin	Danio rerio	157-169
21842492-6	2011	More importantly, a significant increase in the level of vitellogenin was observed in all male fish treated with beta-endosulfan.	Endosulfan	113-128	vitellogenin	Danio rerio	57-69
21842492-7	2011	Based on these findings, we conclude that beta-endosulfan severely affects the reproductive function of zebrafish and the synthesis of vitellogenin in the liver, and thus, beta-endosulfan has a serious endocrine disruption function in zebrafish.	Endosulfan	42-57	vitellogenin	Danio rerio	135-147
21842492-7	2011	Based on these findings, we conclude that beta-endosulfan severely affects the reproductive function of zebrafish and the synthesis of vitellogenin in the liver, and thus, beta-endosulfan has a serious endocrine disruption function in zebrafish.	Endosulfan	172-187	vitellogenin	Danio rerio	135-147
22677888-10	2012	Taken together, these results indicate that endosulfan profoundly alters the phenotype of liver cells by inducing cell detachment and partial EMT as well as disrupting the anoikis process.	Endosulfan	44-54	IL2 inducible T cell kinase	Homo sapiens	142-145
22459995-0	2012	Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio).	Endosulfan	0-10	acetylcholinesterase	Danio rerio	35-39
22459995-7	2012	Our results reinforce AChE activity inhibition as a pathway of endosulfan-induced toxicity in brain of fish species.	Endosulfan	63-73	acetylcholinesterase	Danio rerio	22-26
21804306-0	2011	Endosulfan-induced lipid peroxidation in rat brain and its effect on t-PA and PAI-1: ameliorating effect of vitamins C and E. Endosulfan provokes systemic toxicity in mammals and induces reactive oxygen species (ROS) and lipid peroxidation (LPO).	Endosulfan	0-10	serpin family E member 1	Rattus norvegicus	78-83
21804306-0	2011	Endosulfan-induced lipid peroxidation in rat brain and its effect on t-PA and PAI-1: ameliorating effect of vitamins C and E. Endosulfan provokes systemic toxicity in mammals and induces reactive oxygen species (ROS) and lipid peroxidation (LPO).	Endosulfan	126-136	plasminogen activator, tissue type	Rattus norvegicus	69-73
21804306-0	2011	Endosulfan-induced lipid peroxidation in rat brain and its effect on t-PA and PAI-1: ameliorating effect of vitamins C and E. Endosulfan provokes systemic toxicity in mammals and induces reactive oxygen species (ROS) and lipid peroxidation (LPO).	Endosulfan	126-136	serpin family E member 1	Rattus norvegicus	78-83
20625822-0	2011	Genotoxic evaluation of the insecticide endosulfan based on the induced GADD153-GFP reporter gene expression.	Endosulfan	40-50	DNA damage inducible transcript 3	Homo sapiens	72-79
20625822-6	2011	Endosulfan was able to cause the increase of GADD153-GFP expression at a sublethal dose (0.02-20 mg/L).	Endosulfan	0-10	DNA damage inducible transcript 3	Homo sapiens	45-52
21340455-1	2011	The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats.	Endosulfan	50-60	butyrylcholinesterase	Rattus norvegicus	84-87
21340455-2	2011	ChE activity decreased in dams and in male pups within 65 days corresponding to 35% and 32% of inhibition respectively in the higher endosulfan dose (1.5 mg/kg).	Endosulfan	133-143	butyrylcholinesterase	Rattus norvegicus	0-3
21340455-4	2011	The results suggest that endosulfan is able to inhibit the ChE activity and to cross the placental barrier and/or to be eliminated through milk affecting the enzyme activity in male rat pups.	Endosulfan	25-35	butyrylcholinesterase	Rattus norvegicus	59-62
21366969-1	2011	This study has investigated the effect of two highly toxic pesticides, monocrotophos (organophosphate) and endosulphan (organochlorine), on the inducibility of two major heat shock proteins, the HSP60 and HSP70, essential for cell survival, in the house fly Musca domestica.	Endosulfan	107-118	heat shock 70 kDa protein cognate 4	Musca domestica	205-210
21278053-7	2011	Dieldrin and endosulfan increased Akt phosphorylation in CN, which was inhibited by the ERbeta antagonist 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol.	Endosulfan	13-23	AKT serine/threonine kinase 1	Homo sapiens	34-37
21278053-7	2011	Dieldrin and endosulfan increased Akt phosphorylation in CN, which was inhibited by the ERbeta antagonist 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol.	Endosulfan	13-23	estrogen receptor 2	Homo sapiens	88-94
20361990-0	2010	Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.	Endosulfan	0-10	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-25
20471459-1	2010	The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level.	Endosulfan	90-100	gonadotropin releasing hormone receptor	Rattus norvegicus	223-237
20471459-1	2010	The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level.	Endosulfan	90-100	nitric oxide synthase 1	Rattus norvegicus	346-375
20471459-1	2010	The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level.	Endosulfan	90-100	nitric oxide synthase 1	Rattus norvegicus	377-381
20471459-1	2010	The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level.	Endosulfan	90-100	nitric oxide synthase 2	Rattus norvegicus	386-390
20471459-1	2010	The present study was undertaken to investigate in pubertal male rats possible effects of endosulfan administered throughout lactation and gestation on: (a) pituitary gene expression of prolactin, luteinizing hormone (LH), growth hormone (GH) and thyroid stimulating hormone (TSH); (b) circulating levels of these hormones; and (c) expression of nitric oxide synthase 1 and 2 (NOS1 and NOS2), and heme oxygenase-1 (HO-1) at pituitary level.	Endosulfan	90-100	heme oxygenase 1	Rattus norvegicus	397-413
20471459-8	2010	We can conclude that in pubertal male rat, prenatal and lactational exposure to endosulfan modifies expression and release of prolactin, LH, GH and TSH, and pituitary NOS1 and NOS2 mRNA levels, suggesting that nitrosative stress can be implicated in the endocrine toxicity of endosulfan at pituitary level.	Endosulfan	80-90	nitric oxide synthase 1	Rattus norvegicus	167-171
20471459-8	2010	We can conclude that in pubertal male rat, prenatal and lactational exposure to endosulfan modifies expression and release of prolactin, LH, GH and TSH, and pituitary NOS1 and NOS2 mRNA levels, suggesting that nitrosative stress can be implicated in the endocrine toxicity of endosulfan at pituitary level.	Endosulfan	80-90	nitric oxide synthase 2	Rattus norvegicus	176-180
20507880-6	2010	Second, by using these transformants, beta-endosulfan, a chemical for which the CYP isoforms contributing to its genotoxicity are unknown, was found to induce MN through the CYP3A4-mediated pathway.	Endosulfan	38-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	174-180
20507880-7	2010	This result was confirmed by the facts that the decreased CYP3A4 activity using a inhibitor or short interfering RNA (siRNA) repressed MN induction by beta-endosulfan and that endosulfan sulfate, one of the metabolites produced by CYP3A4, induced MN in the transformants harboring an empty vector.	Endosulfan	151-166	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
20361990-0	2010	Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.	Endosulfan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
20361990-0	2010	Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.	Endosulfan	0-10	nuclear receptor subfamily 1 group I member 2	Homo sapiens	55-74
20361990-2	2010	Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expression of cytochrome P450 (CYP) enzymes.	Endosulfan	0-10	nuclear receptor subfamily 1 group I member 2	Homo sapiens	130-149
20361990-2	2010	Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expression of cytochrome P450 (CYP) enzymes.	Endosulfan	0-10	nuclear receptor subfamily 1 group I member 2	Homo sapiens	151-154
20361990-2	2010	Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expression of cytochrome P450 (CYP) enzymes.	Endosulfan	0-10	CXADR Ig-like cell adhesion molecule	Homo sapiens	201-204
20361990-8	2010	These data indicate that endosulfan-alpha significantly activates hPXR strongly and hCAR weakly.	Endosulfan	25-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	66-70
20361990-8	2010	These data indicate that endosulfan-alpha significantly activates hPXR strongly and hCAR weakly.	Endosulfan	25-41	CXADR Ig-like cell adhesion molecule	Homo sapiens	84-88
20361990-10	2010	In mPXR-null/hPXR-transgenic mice, endosulfan-alpha exposure (2.5mg/kg/day) caused a significant reduction of tribromoethanol-induced sleep times by approximately 50%, whereas no significant change in sleep times was observed in PXR-null mice.	Endosulfan	35-45	nuclear receptor subfamily 1 group I member 2	Homo sapiens	13-17
20361990-10	2010	In mPXR-null/hPXR-transgenic mice, endosulfan-alpha exposure (2.5mg/kg/day) caused a significant reduction of tribromoethanol-induced sleep times by approximately 50%, whereas no significant change in sleep times was observed in PXR-null mice.	Endosulfan	35-45	nuclear receptor subfamily 1, group I, member 2	Mus musculus	4-7
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	nuclear receptor subfamily 1 group I member 2	Homo sapiens	73-76
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-98
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-148
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158
21783720-4	2006	Results showed that out of 14 pure pesticides tested, endosulfan, phosalone and propiconazole were nearly as potent as model inhibitor verapamil (EC(50)=1.5muM), while diazinon showed a lower potency of inhibiting P-gp transport activity (EC(50)=58.4muM).	Endosulfan	54-64	phosphoglycolate phosphatase	Mus musculus	214-218
20214973-6	2010	The activities of the antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidise (GSH-Px) and glutathione-S-transferase (GST) were decreased by fenitrothion incubation more than endosulfan and abamectin.	Endosulfan	195-205	hematopoietic prostaglandin D synthase	Rattus norvegicus	138-141
20214973-8	2010	The activities of glutathione-S-transferase (GST) and gamma glutamyl transpeptidase (gamma-GT) were more affected by fenitrothion and endosulfan, respectively, indicating an oxidative stress.	Endosulfan	134-144	hematopoietic prostaglandin D synthase	Rattus norvegicus	18-43
20214973-8	2010	The activities of glutathione-S-transferase (GST) and gamma glutamyl transpeptidase (gamma-GT) were more affected by fenitrothion and endosulfan, respectively, indicating an oxidative stress.	Endosulfan	134-144	hematopoietic prostaglandin D synthase	Rattus norvegicus	45-48
20214973-8	2010	The activities of glutathione-S-transferase (GST) and gamma glutamyl transpeptidase (gamma-GT) were more affected by fenitrothion and endosulfan, respectively, indicating an oxidative stress.	Endosulfan	134-144	gamma-glutamyltransferase 1	Rattus norvegicus	54-83
20214973-8	2010	The activities of glutathione-S-transferase (GST) and gamma glutamyl transpeptidase (gamma-GT) were more affected by fenitrothion and endosulfan, respectively, indicating an oxidative stress.	Endosulfan	134-144	gamma-glutamyltransferase 1	Rattus norvegicus	85-93
20214973-12	2010	Endosulfan induced cell membrane damage of the hepatocytes more than abamectin and fenitrothion as indicated by increasing the leakage percentages of LDH, ALT, AST and gamma-GT.	Endosulfan	0-10	gamma-glutamyltransferase 1	Rattus norvegicus	168-176
19285844-15	2010	However, toxicity was decreased by Vit C treatment, which reduced the accumulation of endosulfan in livers four-fold.	Endosulfan	86-96	vitrin	Oryctolagus cuniculus	35-38
17503468-4	2007	We first found that 25 microM endosulfan led to persistent extracellular signal-regulated kinase (ERK)1/2 phosphorylation with an accumulation of the phosphorylated form in the nucleus, probably caused by MAP kinase phosphatase (MKP) inhibition.	Endosulfan	30-40	mitogen-activated protein kinase 1	Homo sapiens	59-105
17503468-6	2007	In addition, endosulfan has been shown to generate transient reactive oxygen species (ROS), and blocking this oxidative stress by N-acetyl cysteine (NAC) strongly prevented both persistent nuclear ERK1/2 phosphorylation and cell growth decrease.	Endosulfan	13-23	mitogen-activated protein kinase 3	Homo sapiens	197-203
17503468-10	2007	Taken together, these findings strongly support that endosulfan induces ROS generation leading to sustained ERK1/2 phosphorylation and decrease in cell growth.	Endosulfan	53-63	mitogen-activated protein kinase 3	Homo sapiens	108-114
17490606-1	2007	We studied the effects of four commonly used insecticides (methylparathion, endosulfan, cypermethrin and fenvalerate) on P-glycoprotein isolated from multidrug-resistant cells.	Endosulfan	76-86	ATP binding cassette subfamily B member 1	Homo sapiens	121-135
17261270-6	2007	The transient transfection and electrophoretic mobility shift assays with the NF-kappaB binding sites showed that the NF-kappaB transcription factor mediated the endosulfan-induced increase in the expression levels of iNOS and proinflammatory cytokines.	Endosulfan	162-172	inositol-3-phosphate synthase 1	Homo sapiens	218-222
17189834-9	2007	Taken together, these findings suggest that the cytotoxicity of endosulfan and zineb, both individually and in mixtures may, at least in part, be associated with the generation of reactive oxygen species with concomitant increased expression of NFkappaB.	Endosulfan	64-74	nuclear factor kappa B subunit 1	Homo sapiens	245-253
19957884-1	2009	Endosulfan exposure (8 and 16 mg/kg) to rats significantly decreased the activities of superoxide dismutase and catalase, level of reduced glutathione and increased lipid peroxidation.	Endosulfan	0-10	catalase	Rattus norvegicus	112-120
18443843-8	2009	Catalase was decreased with endosulfan and the coexposure, but not with arsenic, whereas GSH was decreased with arsenic and endosulfan, but not with the coexposure.	Endosulfan	28-38	catalase	Gallus gallus	0-8
18790044-6	2008	PR, ERalpha and C3 expression levels were modified in most of the endosulfan-treated groups, showing an identical pattern of expression to the NUE(2)-group.	Endosulfan	66-76	progesterone receptor	Rattus norvegicus	0-2
18790044-6	2008	PR, ERalpha and C3 expression levels were modified in most of the endosulfan-treated groups, showing an identical pattern of expression to the NUE(2)-group.	Endosulfan	66-76	estrogen receptor 1	Rattus norvegicus	4-11
18790044-6	2008	PR, ERalpha and C3 expression levels were modified in most of the endosulfan-treated groups, showing an identical pattern of expression to the NUE(2)-group.	Endosulfan	66-76	complement C3	Rattus norvegicus	16-18
18205731-7	2008	Endosulfan administration caused a significant decrease in tissue GSH and plasma AOC, which was accompanied with significant rises in tissue MDA and collagen levels and MPO activity.	Endosulfan	0-10	myeloperoxidase	Rattus norvegicus	169-172
16884889-9	2006	HSP27 was found to be underexpressed at concentrations of imidacloprid or endosulfan (as Techn"ufan) lower than IC50.	Endosulfan	74-84	heat shock protein family B (small) member 1	Homo sapiens	0-5
16884889-11	2006	GRP78 was up-regulated by endosulfan in A549, but not in SH-SY5Y cells, suggesting a damaging effect on proteins specific to pulmonary cells.	Endosulfan	26-36	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
16855053-7	2006	This study shows that endosulfan-alpha is metabolized by HLMs to a single metabolite, endosulfan sulfate, and that it has potential use, in combination with inhibitors, as an in vitro probe for CYP2B6 and 3A4 catalytic activities.	Endosulfan	22-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	194-200
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	159-175	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	220-226
16626760-6	2006	Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively.	Endosulfan	188-198	estrogen receptor 1	Homo sapiens	31-51
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	231-237
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	159-175	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	264-269
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	290-296
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	301-307
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	256-271	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	211-217
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	256-271	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	219-225
16581944-7	2006	The total CL(int) values of endosulfan sulfate formation catalyzed by CYP3A4 and CYP3A5 were consistently higher for beta-endosulfan than for the alpha-form (CL(int) of 0.67 versus 10.46 microl/min/pmol P450, respectively).	Endosulfan	117-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76
16581944-7	2006	The total CL(int) values of endosulfan sulfate formation catalyzed by CYP3A4 and CYP3A5 were consistently higher for beta-endosulfan than for the alpha-form (CL(int) of 0.67 versus 10.46 microl/min/pmol P450, respectively).	Endosulfan	117-132	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	81-87
16581944-8	2006	CYP2B6 enantioselectively metabolizes alpha-endosulfan, but not beta-endosulfan.	Endosulfan	38-54	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6
16581944-9	2006	These findings suggest that the CYP2B6 and CYP3A enzymes are major enzymes contributing to the stereoselective disposition of endosulfan.	Endosulfan	126-136	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	32-38
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	159-175	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	359-364
16581944-9	2006	These findings suggest that the CYP2B6 and CYP3A enzymes are major enzymes contributing to the stereoselective disposition of endosulfan.	Endosulfan	126-136	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-48
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	313-328	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	220-226
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	211-217
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	219-225
15337585-4	2004	SOD, GPx, CAT activities and MDA level increased in the endosulfan-treated group heart tissue compared to control group (P < 0.01, P < 0.01, P < 0.05 and P < 0.01, respectively).	Endosulfan	56-66	catalase	Rattus norvegicus	10-13
15888667-2	2005	The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation.	Endosulfan	76-86	mitogen-activated protein kinase 3	Homo sapiens	150-154
16537435-1	2006	Several major insecticides, including alpha-endosulfan, lindane, and fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA receptor.	Endosulfan	38-54	GABA type A receptor-associated protein	Homo sapiens	156-169
16054614-7	2005	Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR.	Endosulfan	62-72	nuclear receptor subfamily 1 group I member 2	Homo sapiens	137-140
16054614-7	2005	Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR.	Endosulfan	62-72	nuclear receptor subfamily 1 group I member 2	Homo sapiens	149-152
16054614-7	2005	Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR.	Endosulfan	62-72	nuclear receptor subfamily 1 group I member 3	Homo sapiens	157-160
15589975-1	2005	Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE).	Endosulfan	81-91	retinoic acid receptor alpha	Homo sapiens	108-130
15589975-1	2005	Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE).	Endosulfan	81-91	retinoic acid receptor alpha	Homo sapiens	132-135
15337585-7	2004	CAT activity increased in the vitamin E + endosulfan treated group compared to control group (P < 0.05).	Endosulfan	42-52	catalase	Rattus norvegicus	0-3
14575683-5	2003	The inhibition produced by endosulfan in vivo was of mixed noncompetitive/uncompetitive type for crude as well as purified cMDH and mMDH.	Endosulfan	27-37	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	132-136
14636831-9	2003	Endosulfan did not have any influence on nitrite production, but suppressed the LPS-induced TNF-alpha generation.	Endosulfan	0-10	tumor necrosis factor	Rattus norvegicus	92-101
15261991-7	2004	Co-exposure with E2 elicited a significant increased ERbeta mRNA level by prochloraz, fenarimol, endosulfan, dieldrin, and tolchlofos-methyl, whereas no significant effect of the carbamate pesticides on the ERbeta mRNA level was observed.	Endosulfan	97-107	estrogen receptor 2	Homo sapiens	53-59
14575683-9	2003	These results demonstrate inhibitory effects of endosulfan on skeletal muscle MDH of the freshwater catfish Clarias batrachus and inhibition effects are mediated through enzyme/substrate/endosulfan complexing.	Endosulfan	48-58	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	78-81
14575683-9	2003	These results demonstrate inhibitory effects of endosulfan on skeletal muscle MDH of the freshwater catfish Clarias batrachus and inhibition effects are mediated through enzyme/substrate/endosulfan complexing.	Endosulfan	187-197	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	78-81
11358810-5	2001	Here we show that in MCF-7 cells, 17beta-estradiol and alpha-endosulfan can repress whole cell ethoxyresorufin-O-deethylase activity, lowering CYP1A1 mRNA levels as well as promoter activity as assessed by transient transfection assays.	Endosulfan	55-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
14649713-4	2003	Alpha endosulfan could be removed up to 94% at pH 4 for an ozonation time of 60 minutes.	Endosulfan	0-16	prolyl 4-hydroxylase, transmembrane	Homo sapiens	47-51
12711413-6	2003	Glutathione peroxidase (GPx) activity was significantly reduced at doses of endosulfan that also reduced levels of glutathione, an essential cofactor of GPx.	Endosulfan	76-86	glutathione peroxidase 1	Oncorhynchus mykiss	0-22
12711413-6	2003	Glutathione peroxidase (GPx) activity was significantly reduced at doses of endosulfan that also reduced levels of glutathione, an essential cofactor of GPx.	Endosulfan	76-86	glutathione peroxidase 1	Oncorhynchus mykiss	24-27
12711413-6	2003	Glutathione peroxidase (GPx) activity was significantly reduced at doses of endosulfan that also reduced levels of glutathione, an essential cofactor of GPx.	Endosulfan	76-86	glutathione peroxidase 1	Oncorhynchus mykiss	153-156
11767051-14	2001	2, 4, 5-HCB and endosulfan decreased the expression of connexin 43 in dose dependent manner.	Endosulfan	16-26	gap junction protein, alpha 1	Rattus norvegicus	55-66
12841624-3	2003	Using both cell free system and Jurkat cells as in vitro models, we demonstrate that endosulfan can generate oxygen radicals that is inhibitable by superoxide dismutase (SOD) and glutathione (GSH).	Endosulfan	85-95	superoxide dismutase 1	Homo sapiens	148-168
12841624-3	2003	Using both cell free system and Jurkat cells as in vitro models, we demonstrate that endosulfan can generate oxygen radicals that is inhibitable by superoxide dismutase (SOD) and glutathione (GSH).	Endosulfan	85-95	superoxide dismutase 1	Homo sapiens	170-173
12030773-6	2002	Our results show that endosulfan and chlordane are able to induce a substantial increase of PRL expression while these two chemicals do not increase cell growth.	Endosulfan	22-32	prolactin	Homo sapiens	92-95
12030773-7	2002	Together, our results suggest that endosulfan and chlordane could indeed modulate an estrogen-inducible gene such as PRL, possibly acting via second messenger-mediated cellular mechanisms instead of solely competing with estrogens for the nuclear estrogen receptor sites.	Endosulfan	35-45	prolactin	Homo sapiens	117-120
11358810-10	2001	In human hepatoma HepG2 cells, which lack functional ER, alpha-endosulfan, but not 17beta-estradiol, displays a repressive effect on CYP1A1 through a different mechanism.	Endosulfan	57-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
11358810-10	2001	In human hepatoma HepG2 cells, which lack functional ER, alpha-endosulfan, but not 17beta-estradiol, displays a repressive effect on CYP1A1 through a different mechanism.	Endosulfan	57-73	estrogen receptor 1	Homo sapiens	53-55
8917702-6	1996	One pesticide, endosulfan, exhibited slight though significant transport mediated by P-gp.	Endosulfan	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
10821422-14	2000	We also examined whether this occurred by the down regulation of bcl-2 protein expression that is likely to increase the susceptibility of Jurkat cells to endosulfan toxicity.	Endosulfan	155-165	BCL2 apoptosis regulator	Homo sapiens	65-70
10821422-15	2000	Paradoxically, the intracellular expression of bcl-2 protein was elevated in a dose dependent manner suggesting endosulfan-induced apoptosis occurred by a non-bcl-2 pathway.	Endosulfan	112-122	BCL2 apoptosis regulator	Homo sapiens	47-52
10821422-15	2000	Paradoxically, the intracellular expression of bcl-2 protein was elevated in a dose dependent manner suggesting endosulfan-induced apoptosis occurred by a non-bcl-2 pathway.	Endosulfan	112-122	BCL2 apoptosis regulator	Homo sapiens	159-164
10397250-7	1999	Diethylstilbestrol, coumestrol, genistein, naringenin, and endosulfan were able to activate the AF2 function of the ER in vitro and demonstrated agonist activity in estrogen-responsive myometrial cells, as determined by induction of proliferation and increased message levels of progesterone receptor.	Endosulfan	59-69	estrogen receptor 1	Homo sapiens	116-118
9580081-7	1998	The stability of endosulfan on C18 Empore disks has been determined at 20 degrees C, 4 degrees C and -20 degrees C for periods up to 3 months.	Endosulfan	17-27	Bardet-Biedl syndrome 9	Homo sapiens	31-34
9465275-0	1998	Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice.	Endosulfan	0-10	CD1 antigen complex	Mus musculus	68-72
9465275-2	1998	Endosulfan, an organochlorine insecticide that has been demonstrated to induce hepatic P450 biotransformation enzymes, was examined for its ability to alter the rate of steroid hormone metabolism in CD-1 mice.	Endosulfan	0-10	CD1 antigen complex	Mus musculus	199-203
11787861-3	2001	In this study, the organochlorine xenobiotics dieldrin and endosulfan, at micromolar concentrations, were found to inhibit gap junction-mediated intercellular communication and induce hypophosphorylation of connexin 43 in cultured rat astrocytes, the predominant cell type in the brain coupled through gap junctions.	Endosulfan	59-69	gap junction protein, alpha 1	Rattus norvegicus	207-218
11787861-5	2001	Chaetoglobosin K also prevented dieldrin and endosulfan-induced hypophosphorylation of connexin 43 and prevented dieldrin-induced connexin 43 plaque dissolution in both astrocytes and cultured liver epithelial cells.	Endosulfan	45-55	gap junction protein alpha 1	Homo sapiens	87-98
11673846-3	2001	On the other hand, puffing data revealed that endosulfan at lower doses, induced well-developed puff at the resident site (93D) of the hsromega gene but the transgenic sites (30B in 951-lacZ2 and 44B in 498-lacZ1 strain) did not show any well-developed puff.	Endosulfan	46-56	Heat shock RNA omega	Drosophila melanogaster	135-143
11673846-3	2001	On the other hand, puffing data revealed that endosulfan at lower doses, induced well-developed puff at the resident site (93D) of the hsromega gene but the transgenic sites (30B in 951-lacZ2 and 44B in 498-lacZ1 strain) did not show any well-developed puff.	Endosulfan	46-56	beta galactosidase	Drosophila melanogaster	207-212
10397250-7	1999	Diethylstilbestrol, coumestrol, genistein, naringenin, and endosulfan were able to activate the AF2 function of the ER in vitro and demonstrated agonist activity in estrogen-responsive myometrial cells, as determined by induction of proliferation and increased message levels of progesterone receptor.	Endosulfan	59-69	progesterone receptor	Homo sapiens	279-300
9185323-3	1997	The inhibition produced by endosulfan was of mixed non-competitive-uncompetitive type (KiE > KiES) and of mixed competitive-non-competitive type (KiE < KiES) for crude cMDH and mMDH, respectively.	Endosulfan	27-37	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	183-187
9185323-11	1997	Summarizing, it can be stated that endosulfan exerts an inhibitory effect on crude cMDH and mMDH in vivo, and their purified isoforms (C5-cMDH and M2-mMDH) in vivo as well as in vitro.	Endosulfan	35-45	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	92-96
9185323-11	1997	Summarizing, it can be stated that endosulfan exerts an inhibitory effect on crude cMDH and mMDH in vivo, and their purified isoforms (C5-cMDH and M2-mMDH) in vivo as well as in vitro.	Endosulfan	35-45	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	150-154
9185323-12	1997	The impact of endosulfan is mediated through enzyme-substrate-endosulfan (ES-END) complexing for cMDH and enzyme-endosulfan (E-END) complexing for mMDH.	Endosulfan	14-24	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	147-151
21781690-0	1996	Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.	Endosulfan	43-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-32
21781690-8	1996	To examine if endosulfan induces CYP1A-, CYP2B-, or CYP3A-family transcripts, we measured transcript levels by Northern blot and RT-PCR analyses.	Endosulfan	14-24	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	41-46
21781690-8	1996	To examine if endosulfan induces CYP1A-, CYP2B-, or CYP3A-family transcripts, we measured transcript levels by Northern blot and RT-PCR analyses.	Endosulfan	14-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-57
21781690-9	1996	Endosulfan appears to selectively induce expression of the CYP3A gene family.	Endosulfan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-64
8020150-6	1994	Immunoblot analysis after endosulfan-exposure showed a slightly increased phosphorylation of cx43 after 10 min treatment, gradually followed by dephosphorylation during the rest of the 24 h treatment period.	Endosulfan	26-36	gap junction protein, alpha 1	Rattus norvegicus	93-97
8020150-8	1994	After 4 h of exposure immunofluorescent cx43-plaques started to reappear in the cell membrane, although less pronounced in endosulfan-treated cells.	Endosulfan	123-133	gap junction protein, alpha 1	Rattus norvegicus	40-44
8020150-9	1994	However, after 24 h of endosulfan-exposure a high number of cx43-spots was demonstrated.	Endosulfan	23-33	gap junction protein, alpha 1	Rattus norvegicus	60-64
2279768-4	1990	Activities of steroidogenic enzymes studied (3 beta- and 17 beta-hydroxysteroid dehydrogenases) were considerably lowered on longer exposure of endosulfan.	Endosulfan	144-154	aldo-keto reductase family 1, member C12	Rattus norvegicus	47-94
7900959-18	1993	(d) Hematologic toxicity: endosulfan exposure resulted in a significant decrease in the erythrocyte glutathione reductase, hemoglobin amount, RBC number and mean corpuscular volume.	Endosulfan	26-36	glutathione-disulfide reductase	Rattus norvegicus	100-121
7900959-22	1993	Biochemical: in rats, endosulfan caused increased glucose-6-phosphate dehydrogenase activity, blood glucose level, phospholipid contents of the microsomal and surfactant system, and profoundly induced the activity of alcohol dehydrogenase and cytosolic glutathione S-transferases.	Endosulfan	22-32	glucose-6-phosphate dehydrogenase	Rattus norvegicus	50-83
8406551-5	1993	At 40 degrees C and 1 mM drug concentration, aldrin, endosulfan, melathion and anilophos were found to be strong labilizers of the lysosomal membrane.	Endosulfan	53-63	cullin-associated NEDD8-dissociated protein 1	Capra hircus	14-21
2331326-1	1990	A sublethal concentration of technical grade endosulfan (END) inhibited 35 to 55% of the activities of cytoplasmic malate dehydrogenase (cMDH), mitochondrial malate dehydrogenase (mMDH), and lactate dehydrogenase (LDH) in the liver and the skeletal muscle of a freshwater catfish, Clarias batrachus, after 7 days of exposure.	Endosulfan	45-55	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	180-184
35567928-2	2022	We have shown that a single sublethal dose of endosulfan caused high induction of oxidative stress in the liver and brain by altering the antioxidant status, as shown by reduction in the antioxidant enzymes SOD, GPx, GST, GR along with increased ROS and lipid peroxidation.	Endosulfan	46-56	glutathione-disulfide reductase	Rattus norvegicus	222-224
34523106-8	2022	Also, combined exposure of BPA, Pb and ES caused apoptotic cell numbers and inducible nitric oxide (iNOS) to increase in the liver and kidney tissues.	Endosulfan	39-41	nitric oxide synthase 2	Rattus norvegicus	100-104
34856488-0	2021	Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-beta/Smad signaling pathway in HRMCs.	Endosulfan	0-10	transforming growth factor alpha	Homo sapiens	85-93
34856488-0	2021	Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-beta/Smad signaling pathway in HRMCs.	Endosulfan	0-10	SMAD family member 7	Homo sapiens	94-98
34856488-5	2021	The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8.	Endosulfan	24-34	dynactin subunit 6	Homo sapiens	111-114
34856488-5	2021	The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8.	Endosulfan	24-34	H3 histone pseudogene 16	Homo sapiens	181-184
34856488-5	2021	The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8.	Endosulfan	24-34	interleukin 6	Homo sapiens	210-214
34856488-5	2021	The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8.	Endosulfan	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
34856488-8	2021	Endosulfan significantly decreased the activity of SOD and increased the MDA level and CAT activity, which were reversed in the presence of NAC.	Endosulfan	0-10	superoxide dismutase 1	Homo sapiens	51-54
34856488-8	2021	Endosulfan significantly decreased the activity of SOD and increased the MDA level and CAT activity, which were reversed in the presence of NAC.	Endosulfan	0-10	catalase	Homo sapiens	87-90
34856488-8	2021	Endosulfan significantly decreased the activity of SOD and increased the MDA level and CAT activity, which were reversed in the presence of NAC.	Endosulfan	0-10	synuclein alpha	Homo sapiens	140-143
34856488-9	2021	These findings suggest that endosulfan can cause excessive proliferation and massive accumulation of ECM through TGF-beta/Smad signaling pathway, and also induced oxidative stress and inflammation in HRMCs.	Endosulfan	28-38	transforming growth factor alpha	Homo sapiens	113-121
34856488-9	2021	These findings suggest that endosulfan can cause excessive proliferation and massive accumulation of ECM through TGF-beta/Smad signaling pathway, and also induced oxidative stress and inflammation in HRMCs.	Endosulfan	28-38	SMAD family member 7	Homo sapiens	122-126
35114330-0	2022	Aberrant Hoxa10 gene methylation as a mechanism for endosulfan-induced implantation failures in rats.	Endosulfan	52-62	homeobox A10	Rattus norvegicus	9-15
35114330-4	2022	In this study, we evaluated whether early postnatal exposure to endosulfan affects long-term transcriptional regulation of Homeobox A10 (Hoxa10) gene, which is a key marker of endometrial receptivity.	Endosulfan	64-74	homeobox A10	Rattus norvegicus	123-135
35114330-4	2022	In this study, we evaluated whether early postnatal exposure to endosulfan affects long-term transcriptional regulation of Homeobox A10 (Hoxa10) gene, which is a key marker of endometrial receptivity.	Endosulfan	64-74	homeobox A10	Rattus norvegicus	137-143
35114330-10	2022	In addition, endosulfan increased levels of Dnmt3a and Dnmt3b.	Endosulfan	13-23	DNA methyltransferase 3 alpha	Rattus norvegicus	44-50
35114330-10	2022	In addition, endosulfan increased levels of Dnmt3a and Dnmt3b.	Endosulfan	13-23	DNA methyltransferase 3 beta	Rattus norvegicus	55-61
35114330-12	2022	All these results suggest that aberrant DNA methylation in Hoxa10 gene could be an underlining mechanism contributing to explain endosulfan-induced preimplantation losses.	Endosulfan	129-139	homeobox A10	Rattus norvegicus	59-65
35051067-8	2022	Treatment of MCF-7 cells with p,p"-DDT or endosulfan decreased the protein levels of apoptosis regulators TP53INP1 and APAF1.	Endosulfan	42-52	tumor protein p53 inducible nuclear protein 1	Homo sapiens	106-114
35051067-8	2022	Treatment of MCF-7 cells with p,p"-DDT or endosulfan decreased the protein levels of apoptosis regulators TP53INP1 and APAF1.	Endosulfan	42-52	apoptotic peptidase activating factor 1	Homo sapiens	119-124
4093546-0	1985	Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins.	Endosulfan	67-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
3388749-6	1988	However, a significant decrease in liver GOT and GPT and serum GPT activities and a significant rise in serum alkaline phosphatase and total protein were recorded in the endosulfan-treated animals.	Endosulfan	170-180	glutamic--pyruvic transaminase	Rattus norvegicus	49-52
3388749-6	1988	However, a significant decrease in liver GOT and GPT and serum GPT activities and a significant rise in serum alkaline phosphatase and total protein were recorded in the endosulfan-treated animals.	Endosulfan	170-180	glutamic--pyruvic transaminase	Rattus norvegicus	63-66
3775804-2	1986	Rats exposed to 1 mg and 3 mg endosulfan/kg for periods of 10, 30, and 60 days showed significant (P less than 0.05) inhibition of [3H]5-hydroxytryptamine (5-HT) uptake by platelet-rich plasma (PRP) in an ex vivo study.	Endosulfan	30-40	proline rich protein 2-like 1	Rattus norvegicus	194-197
3775804-4	1986	Incubation of PRP with 10 microM and 100 microM endosulfan for 15 min at 37 degrees C also resulted in significant (P less than 0.05) inhibition of platelet aggregation in vitro.	Endosulfan	48-58	proline rich protein 2-like 1	Rattus norvegicus	14-17
30426790-3	2020	In SPR studies, only endosulfan showed binding to SUMO1 (Kd1.313 x 10-4 M).	Endosulfan	21-31	small ubiquitin like modifier 1	Homo sapiens	50-55
3971059-0	1985	Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats.	Endosulfan	50-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-110
6424426-2	1983	Endosulfan administration (ten days) significantly increased microsomal protein content and cytochrome P-450 levels, NADPH cytochrome C-reductase aminopyrine N-demethylase and aniline hydroxylase activities, with respect to control rats.	Endosulfan	0-10	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	92-108
6424426-3	1983	Administration of vitamin A (10,000 I.U./100 g body weight) daily for ten days reduced the activity of the above mentioned enzymes, when vitamin A and endosulfan were given together, vitamin A reduced the endosulfan induced increase of microsomal proteins and cytochrome P-450 levels, the activity of NADPH cytochrome C-reductase, aminopyrine N-demethylase and aniline-hydroxylase.	Endosulfan	151-161	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	260-276
30426790-0	2020	Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9.	Endosulfan	10-20	ubiquitin conjugating enzyme E2 I	Homo sapiens	67-71
6407155-3	1983	Our results show that malathion is more toxic than endosulfan, that adult males are more sensitive to both insecticides than females, and that resistance of ER1 and ER2 strains is restricted to the insecticide to which they had been exposed previously (endosulfan).	Endosulfan	253-263	l(3)93Da	Drosophila melanogaster	157-160
6407155-3	1983	Our results show that malathion is more toxic than endosulfan, that adult males are more sensitive to both insecticides than females, and that resistance of ER1 and ER2 strains is restricted to the insecticide to which they had been exposed previously (endosulfan).	Endosulfan	253-263	l(3)93Cd	Drosophila melanogaster	165-168
30426790-7	2020	In HePG2 cells, endosulfan treatment resulted in elevated mRNA levels of SUMO1, 3 and UBC9, whereas, treatment with bisphenol A resulted in increased mRNA of SUMO2, 3 and UBC9.	Endosulfan	16-26	small ubiquitin like modifier 1	Homo sapiens	73-78
30426790-7	2020	In HePG2 cells, endosulfan treatment resulted in elevated mRNA levels of SUMO1, 3 and UBC9, whereas, treatment with bisphenol A resulted in increased mRNA of SUMO2, 3 and UBC9.	Endosulfan	16-26	ubiquitin conjugating enzyme E2 I	Homo sapiens	86-90
30426790-7	2020	In HePG2 cells, endosulfan treatment resulted in elevated mRNA levels of SUMO1, 3 and UBC9, whereas, treatment with bisphenol A resulted in increased mRNA of SUMO2, 3 and UBC9.	Endosulfan	16-26	ubiquitin conjugating enzyme E2 I	Homo sapiens	171-175
30426790-9	2020	Apart from influencing the gene expression, endosulfan caused decrease in SUMO1-Sumoylation of few proteins.	Endosulfan	44-54	small ubiquitin like modifier 1	Homo sapiens	74-79
30426790-10	2020	We propose that one reason for the severe health consequences of exposure to endosulfan/bisphenol could be due to induction of oxidative stress and modulation in SUMO and UBC9 gene expression.	Endosulfan	77-87	ubiquitin conjugating enzyme E2 I	Homo sapiens	171-175
32681854-0	2021	Clozapine, nimodipine and endosulfan differentially suppress behavioral defects caused by gain-of-function mutations in a two-pore domain K+ channel (UNC-58).	Endosulfan	26-36	Uncoordinated protein 58	Caenorhabditis elegans	150-156
32413665-0	2020	Endosulfan triggers epithelial-mesenchymal transition via PTP4A3-mediated TGF-beta signaling pathway in prostate cancer cells.	Endosulfan	0-10	protein tyrosine phosphatase 4A3	Homo sapiens	58-64
32413665-0	2020	Endosulfan triggers epithelial-mesenchymal transition via PTP4A3-mediated TGF-beta signaling pathway in prostate cancer cells.	Endosulfan	0-10	transforming growth factor alpha	Homo sapiens	74-82
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	cadherin 1	Homo sapiens	75-85
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	fibronectin 1	Homo sapiens	114-125
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	snail family transcriptional repressor 2	Homo sapiens	127-133
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	zinc finger E-box binding homeobox 2	Homo sapiens	135-139
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	twist family bHLH transcription factor 1	Homo sapiens	141-147
32413665-4	2020	Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin.	Endosulfan	0-10	vimentin	Homo sapiens	152-160
32413665-7	2020	Endosulfan promoted cell migration and invasion, which were rescued by specific inhibitors for PTP4A3, TGF-beta signaling and Notch signaling, respectively.	Endosulfan	0-10	protein tyrosine phosphatase 4A3	Homo sapiens	95-101
32413665-7	2020	Endosulfan promoted cell migration and invasion, which were rescued by specific inhibitors for PTP4A3, TGF-beta signaling and Notch signaling, respectively.	Endosulfan	0-10	transforming growth factor alpha	Homo sapiens	103-111
32413665-7	2020	Endosulfan promoted cell migration and invasion, which were rescued by specific inhibitors for PTP4A3, TGF-beta signaling and Notch signaling, respectively.	Endosulfan	0-10	notch receptor 1	Homo sapiens	126-131
32413665-8	2020	These findings suggest that endosulfan promoted cell migration and invasion with the induction of EMT through PTP4A3-mediated TGF-beta signaling pathway in prostate cancer cells.	Endosulfan	28-38	protein tyrosine phosphatase 4A3	Homo sapiens	110-116
32413665-8	2020	These findings suggest that endosulfan promoted cell migration and invasion with the induction of EMT through PTP4A3-mediated TGF-beta signaling pathway in prostate cancer cells.	Endosulfan	28-38	transforming growth factor alpha	Homo sapiens	126-134
32344260-7	2020	In addition, endosulfan obviously inhibited Bcl-2 expression, activated the expressions of cytochrome c/Caspase-9/Caspase-3 signaling pathway, and induced the apoptosis of AC16 cells (p < 0.05).	Endosulfan	13-23	BCL2 apoptosis regulator	Homo sapiens	44-49
32344260-7	2020	In addition, endosulfan obviously inhibited Bcl-2 expression, activated the expressions of cytochrome c/Caspase-9/Caspase-3 signaling pathway, and induced the apoptosis of AC16 cells (p < 0.05).	Endosulfan	13-23	cytochrome c, somatic	Homo sapiens	91-103
32344260-7	2020	In addition, endosulfan obviously inhibited Bcl-2 expression, activated the expressions of cytochrome c/Caspase-9/Caspase-3 signaling pathway, and induced the apoptosis of AC16 cells (p < 0.05).	Endosulfan	13-23	caspase 9	Homo sapiens	104-113
32344260-7	2020	In addition, endosulfan obviously inhibited Bcl-2 expression, activated the expressions of cytochrome c/Caspase-9/Caspase-3 signaling pathway, and induced the apoptosis of AC16 cells (p < 0.05).	Endosulfan	13-23	caspase 3	Homo sapiens	114-123
32344260-8	2020	Furthermore, endosulfan significantly increased the expression of Bim, and inhibited the expressions of PI3K/Akt/FoxO3a signaling pathways in cardiomyocytes (p < 0.05).	Endosulfan	13-23	BCL2 like 11	Homo sapiens	66-69
32344260-8	2020	Furthermore, endosulfan significantly increased the expression of Bim, and inhibited the expressions of PI3K/Akt/FoxO3a signaling pathways in cardiomyocytes (p < 0.05).	Endosulfan	13-23	AKT serine/threonine kinase 1	Homo sapiens	109-112
32344260-8	2020	Furthermore, endosulfan significantly increased the expression of Bim, and inhibited the expressions of PI3K/Akt/FoxO3a signaling pathways in cardiomyocytes (p < 0.05).	Endosulfan	13-23	forkhead box O3	Homo sapiens	113-119
32681854-8	2021	We confirmed that endosulfan, a GABA-A receptor antagonist, corrected locomotion in the unc-58(gf) strains.	Endosulfan	18-28	Uncoordinated protein 58	Caenorhabditis elegans	88-94
32361974-0	2020	Endosulfan induces endothelial inflammation and dysfunction via IRE1alpha/NF-kappaB signaling pathway.	Endosulfan	0-10	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	64-73
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	vascular cell adhesion molecule 1	Homo sapiens	270-303
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	vascular cell adhesion molecule 1	Homo sapiens	305-311
32361974-0	2020	Endosulfan induces endothelial inflammation and dysfunction via IRE1alpha/NF-kappaB signaling pathway.	Endosulfan	0-10	nuclear factor kappa B subunit 1	Homo sapiens	74-83
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	endothelin 1	Homo sapiens	317-329
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 1 beta	Homo sapiens	146-163
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	endothelin 1	Homo sapiens	331-335
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 1 alpha	Homo sapiens	165-173
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	126-135
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 6	Homo sapiens	176-189
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	153-162
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	153-162
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 6	Homo sapiens	191-195
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	heat shock protein family A (Hsp70) member 5	Homo sapiens	178-183
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	tumor necrosis factor	Homo sapiens	198-225
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	X-box binding protein 1	Homo sapiens	185-189
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	nuclear factor kappa B subunit 1	Homo sapiens	191-213
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	nuclear factor kappa B subunit 1	Homo sapiens	215-224
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	nuclear factor kappa B subunit 1	Homo sapiens	246-255
32361974-4	2020	We also found that endosulfan could cause ER damage, remarkably increase the expressions of inositol-requiring enzyme 1alpha (IRE1alpha), phosphorylated IRE1alpha (p-IRE1alpha), GRP78, XBP1, nuclear factor-kappa B (NF-kappaB), and phosphorylated NF-kappaB (p-NF-kappaB) in HUVECs.	Endosulfan	19-29	nuclear factor kappa B subunit 1	Homo sapiens	246-255
32361974-6	2020	These results demonstrated that endosulfan-induced endothelial inflammation and dysfunction through the IRE1alpha/NF-kappaB signaling pathway may be triggered by oxidative stress.	Endosulfan	32-42	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	104-113
32361974-6	2020	These results demonstrated that endosulfan-induced endothelial inflammation and dysfunction through the IRE1alpha/NF-kappaB signaling pathway may be triggered by oxidative stress.	Endosulfan	32-42	nuclear factor kappa B subunit 1	Homo sapiens	114-123
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	tumor necrosis factor	Homo sapiens	227-236
32044604-9	2020	Specific inhibitor of PTP4A3 significantly inhibited 20 muM endosulfan-induced cell migration, the expression and phosphorylation of Src and phosphorylation of focal adhesion kinase (FAK).	Endosulfan	60-70	protein tyrosine phosphatase 4A3	Homo sapiens	22-28
32200152-12	2020	Moreover, the low alpha-/beta-endosulfan ratio (median 0.86) specified the fresh use of commercial endosulfan.	Endosulfan	30-40	amyloid beta precursor protein	Homo sapiens	18-29
32044604-9	2020	Specific inhibitor of PTP4A3 significantly inhibited 20 muM endosulfan-induced cell migration, the expression and phosphorylation of Src and phosphorylation of focal adhesion kinase (FAK).	Endosulfan	60-70	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-136
32044604-0	2020	Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.	Endosulfan	0-10	protein tyrosine phosphatase 4A3	Homo sapiens	39-45
32044604-9	2020	Specific inhibitor of PTP4A3 significantly inhibited 20 muM endosulfan-induced cell migration, the expression and phosphorylation of Src and phosphorylation of focal adhesion kinase (FAK).	Endosulfan	60-70	protein tyrosine kinase 2	Homo sapiens	160-181
32044604-9	2020	Specific inhibitor of PTP4A3 significantly inhibited 20 muM endosulfan-induced cell migration, the expression and phosphorylation of Src and phosphorylation of focal adhesion kinase (FAK).	Endosulfan	60-70	protein tyrosine kinase 2	Homo sapiens	183-186
32044604-10	2020	Exposure to endosulfan resulted in activation of various signaling pathways including phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB), which were suppressed by PTP4A3 inhibitor or specific inhibitor for each signaling pathway.	Endosulfan	12-22	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	86-111
32044604-10	2020	Exposure to endosulfan resulted in activation of various signaling pathways including phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB), which were suppressed by PTP4A3 inhibitor or specific inhibitor for each signaling pathway.	Endosulfan	12-22	AKT serine/threonine kinase 1	Homo sapiens	119-122
32044604-10	2020	Exposure to endosulfan resulted in activation of various signaling pathways including phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB), which were suppressed by PTP4A3 inhibitor or specific inhibitor for each signaling pathway.	Endosulfan	12-22	nuclear factor kappa B subunit 1	Homo sapiens	168-190
32044604-10	2020	Exposure to endosulfan resulted in activation of various signaling pathways including phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB), which were suppressed by PTP4A3 inhibitor or specific inhibitor for each signaling pathway.	Endosulfan	12-22	nuclear factor kappa B subunit 1	Homo sapiens	192-201
32044604-10	2020	Exposure to endosulfan resulted in activation of various signaling pathways including phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB), which were suppressed by PTP4A3 inhibitor or specific inhibitor for each signaling pathway.	Endosulfan	12-22	protein tyrosine phosphatase 4A3	Homo sapiens	229-235
32044604-12	2020	These findings suggest that endosulfan promoted cell migration through PTP4A3-mediated various signaling pathways in endothelial cells.	Endosulfan	28-38	protein tyrosine phosphatase 4A3	Homo sapiens	71-77
29772942-7	2020	DMBA + endosulfan co-administration significantly increased CYP1A1-, CYP1A2-, CYP2E-, and GST-associated activities in the rats compared to the control.	Endosulfan	7-17	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	60-66
29772942-7	2020	DMBA + endosulfan co-administration significantly increased CYP1A1-, CYP1A2-, CYP2E-, and GST-associated activities in the rats compared to the control.	Endosulfan	7-17	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	69-75
29772942-11	2020	These findings suggest that CYP1A, CYP3A, and GST enzyme activities participate in the protective mechanism of morin against endosulfan and DMBA induced toxicity.	Endosulfan	125-135	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	35-40
31081291-3	2019	Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50 ) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively.	Endosulfan	32-48	gamma-aminobutyric acid receptor subunit beta	Apis mellifera	134-137
31081291-3	2019	Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50 ) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively.	Endosulfan	32-48	gamma-aminobutyric acid receptor subunit beta	Apis mellifera	139-144
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	catalase	Oreochromis niloticus	79-87
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	catalase	Oreochromis niloticus	89-92
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	superoxide dismutase [Mn], mitochondrial	Oreochromis niloticus	95-115
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	superoxide dismutase [Mn], mitochondrial	Oreochromis niloticus	117-120
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	glutathione peroxidase	Oreochromis niloticus	123-145
31306802-7	2019	Endosulfan caused oxidative stress, as it decreased the values of antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione (GSH), and increased the level of lipid peroxide malondialdehyde (MDA).	Endosulfan	0-10	glutathione peroxidase	Oreochromis niloticus	147-150
30796443-5	2019	Prolonged endosulfan exposure (>9 h) triggered apoptotic signaling, including caspase-2 and -3 activation and protein kinase C delta (PKCdelta) proteolytic activation, ultimately leading to cell death, thus demonstrating that autophagy precedes apoptosis during endosulfan neurotoxicity.	Endosulfan	10-20	caspase 2	Homo sapiens	78-94
30796443-5	2019	Prolonged endosulfan exposure (>9 h) triggered apoptotic signaling, including caspase-2 and -3 activation and protein kinase C delta (PKCdelta) proteolytic activation, ultimately leading to cell death, thus demonstrating that autophagy precedes apoptosis during endosulfan neurotoxicity.	Endosulfan	10-20	protein kinase C delta	Homo sapiens	110-132
30796443-5	2019	Prolonged endosulfan exposure (>9 h) triggered apoptotic signaling, including caspase-2 and -3 activation and protein kinase C delta (PKCdelta) proteolytic activation, ultimately leading to cell death, thus demonstrating that autophagy precedes apoptosis during endosulfan neurotoxicity.	Endosulfan	10-20	protein kinase C delta	Homo sapiens	134-142
30796443-8	2019	Also, caspase-2 and caspase-3 inhibitors effectively blocked endosulfan-induced apoptotic cell death.	Endosulfan	61-71	caspase 2	Homo sapiens	6-15
30796443-8	2019	Also, caspase-2 and caspase-3 inhibitors effectively blocked endosulfan-induced apoptotic cell death.	Endosulfan	61-71	caspase 3	Homo sapiens	20-29
30796443-9	2019	CRISPR/Cas9-based stable knockdown of PKCdelta significantly attenuated endosulfan-induced caspase-3 activation, indicating that the kinase serves as a regulatory switch for apoptosis.	Endosulfan	72-82	protein kinase C delta	Homo sapiens	38-46
30796443-9	2019	CRISPR/Cas9-based stable knockdown of PKCdelta significantly attenuated endosulfan-induced caspase-3 activation, indicating that the kinase serves as a regulatory switch for apoptosis.	Endosulfan	72-82	caspase 3	Homo sapiens	91-100