PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26743002-10 2016 During meiosis, the mre11(SIM2) mutant, as for mre11S, rad50S and sae2Delta, allows initiation but not processing of Spo11-induced DSBs. sae2delta 66-75 MRX complex nuclease subunit Saccharomyces cerevisiae S288C 20-25 29420790-4 2018 By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that restore sae2Delta resistance to both camptothecin and phleomycin affect the Mre11 N-terminus and suppress the resection defect of sae2Delta cells by lowering MRX and Tel1 association to DSBs. sae2delta 131-140 MRE11 homolog, double strand break repair nuclease Homo sapiens 104-109 29420790-4 2018 By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that restore sae2Delta resistance to both camptothecin and phleomycin affect the Mre11 N-terminus and suppress the resection defect of sae2Delta cells by lowering MRX and Tel1 association to DSBs. sae2delta 131-140 MRE11 homolog, double strand break repair nuclease Homo sapiens 199-204 29420790-4 2018 By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that restore sae2Delta resistance to both camptothecin and phleomycin affect the Mre11 N-terminus and suppress the resection defect of sae2Delta cells by lowering MRX and Tel1 association to DSBs. sae2delta 131-140 ETS variant transcription factor 6 Homo sapiens 289-293 29420790-4 2018 By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that restore sae2Delta resistance to both camptothecin and phleomycin affect the Mre11 N-terminus and suppress the resection defect of sae2Delta cells by lowering MRX and Tel1 association to DSBs. sae2delta 253-262 MRE11 homolog, double strand break repair nuclease Homo sapiens 104-109 29420790-6 2018 By contrast, the mre11 mutations restoring sae2Delta resistance only to phleomycin are located in Mre11 C-terminus and bypass Sae2 function in end-tethering but not in DSB resection, possibly by destabilizing the Mre11-Rad50 open conformation. sae2delta 43-52 MRE11 homolog, double strand break repair nuclease Homo sapiens 17-22 29420790-6 2018 By contrast, the mre11 mutations restoring sae2Delta resistance only to phleomycin are located in Mre11 C-terminus and bypass Sae2 function in end-tethering but not in DSB resection, possibly by destabilizing the Mre11-Rad50 open conformation. sae2delta 43-52 MRE11 homolog, double strand break repair nuclease Homo sapiens 98-103 29420790-6 2018 By contrast, the mre11 mutations restoring sae2Delta resistance only to phleomycin are located in Mre11 C-terminus and bypass Sae2 function in end-tethering but not in DSB resection, possibly by destabilizing the Mre11-Rad50 open conformation. sae2delta 43-52 RB binding protein 8, endonuclease Homo sapiens 126-130 29420790-6 2018 By contrast, the mre11 mutations restoring sae2Delta resistance only to phleomycin are located in Mre11 C-terminus and bypass Sae2 function in end-tethering but not in DSB resection, possibly by destabilizing the Mre11-Rad50 open conformation. sae2delta 43-52 MRE11 homolog, double strand break repair nuclease Homo sapiens 213-218 29420790-6 2018 By contrast, the mre11 mutations restoring sae2Delta resistance only to phleomycin are located in Mre11 C-terminus and bypass Sae2 function in end-tethering but not in DSB resection, possibly by destabilizing the Mre11-Rad50 open conformation. sae2delta 43-52 RAD50 double strand break repair protein Homo sapiens 219-224 30510002-2 2018 To initiate resection, Mre11 endonuclease nicks the 5" strands at DSB ends in a reaction stimulated by Sae2CtIP Accordingly, Mre11-nuclease deficient (mre11-nd) and sae2Delta mutants are expected to exhibit similar phenotypes; however, we found several notable differences. sae2delta 165-174 MRE11 homolog, double strand break repair nuclease Homo sapiens 23-28 29466740-5 2018 Resection was totally abolished in the absence of RAD50 on both sides of the break, whereas it was reduced in a sae2Delta mutant on the side of the break containing the longest repeat tract, suggesting that secondary structures at double-strand break ends must be removed by the Mre11-Rad50 complex and Sae2. sae2delta 112-121 MRX complex nuclease subunit Saccharomyces cerevisiae S288C 279-284 29466740-5 2018 Resection was totally abolished in the absence of RAD50 on both sides of the break, whereas it was reduced in a sae2Delta mutant on the side of the break containing the longest repeat tract, suggesting that secondary structures at double-strand break ends must be removed by the Mre11-Rad50 complex and Sae2. sae2delta 112-121 MRX complex DNA-binding subunit Saccharomyces cerevisiae S288C 285-290 29466740-5 2018 Resection was totally abolished in the absence of RAD50 on both sides of the break, whereas it was reduced in a sae2Delta mutant on the side of the break containing the longest repeat tract, suggesting that secondary structures at double-strand break ends must be removed by the Mre11-Rad50 complex and Sae2. sae2delta 112-121 ssDNA endodeoxyribonuclease SAE2 Saccharomyces cerevisiae S288C 303-307 26743002-10 2016 During meiosis, the mre11(SIM2) mutant, as for mre11S, rad50S and sae2Delta, allows initiation but not processing of Spo11-induced DSBs. sae2delta 66-75 Sec63 complex subunit SEC72 Saccharomyces cerevisiae S288C 26-30 18716619-6 2008 We show that mutating Ser 267 of Sae2 to a non-phosphorylatable residue causes phenotypes comparable to those of a sae2Delta null mutant, including hypersensitivity to camptothecin, defective sporulation, reduced hairpin-induced recombination, severely impaired DNA-end processing and faulty assembly and disassembly of HR factors. sae2delta 115-124 ssDNA endodeoxyribonuclease SAE2 Saccharomyces cerevisiae S288C 33-37