PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2699864-4	1989	Results demonstrate a lowering of lipid peroxide levels, xanthine oxidase activity, liver weight and modulation of protein level in liver of the host (mouse) in Plasmodium infection when treated with catechin, glutathione and propylgallate.	Catechin	200-208	xanthine dehydrogenase	Mus musculus	57-73
3379835-10	1988	Cianidanol and sylibin inhibited the elevation of GOT and GPT in anti-BLP induced liver injured mice.	Catechin	0-10	glutamic pyruvic transaminase, soluble	Mus musculus	58-61
2777309-0	1989	Study of interaction between catechin and native and modified bovine serum albumin by physico-chemical methods.	Catechin	29-37	albumin	Homo sapiens	69-82
2777309-1	1989	The interaction of native and modified bovine serum albumin (BSA) with catechin, a flavanoid having vitamin P activity, has been studied using equilibrium dialysis, pH-metric, viscosity and spectrophotometric methods.	Catechin	71-79	albumin	Homo sapiens	46-59
2736747-6	1989	We found significant protection of contractile function (apex displacement) during reperfusion with 50 microM L1 and 20 microM (+)-cyanidanol-3 (p less than 0.01, n = 6), whereas no protection was found with 50 microM kojic acid (n = 6).	Catechin	127-143	ribosomal protein L4	Rattus norvegicus	110-119
3379835-10	1988	Cianidanol and sylibin inhibited the elevation of GOT and GPT in anti-BLP induced liver injured mice.	Catechin	0-10	gastrin releasing peptide	Mus musculus	70-73
2894963-5	1988	Of the epicatechin derivatives, EGCG and ECG showed greater spectral change with oxidized P-450 and time- and concentration-dependent inhibition of the binding of carbon monoxide to dithionite-reduced cytochrome P-450.	Catechin	7-18	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	201-217
2450692-4	1988	Under these conditions, the content of cytochrome P450 was enhanced concomitantly with increases in the total microsomal oxygen uptake, superoxide radical generation and (+)-catechin (cyanid-3-ol) sensitive respiration.	Catechin	170-182	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-54
3229071-3	1988	The high affinity of the polyphenolic compound (+)-catechin for elastin was used to stain the elastic fibers selectively, and enabled automated image analysis.	Catechin	47-59	elastin	Homo sapiens	64-71
2894963-0	1988	Interaction of epicatechins derived from green tea with rat hepatic cytochrome P-450.	Catechin	15-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
2894963-6	1988	The addition of EC, EGC, ECG, and EGCG to microsomes prepared from control, PB- or 3-methylcholanthrene-treated rats resulted in a dose-dependent inhibition of cytochrome P-450-dependent aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-deethylase, and 7-ethoxyresorufin O-deethylase activities.	Catechin	16-18	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	160-176
3678379-0	1987	The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion.	Catechin	28-40	laminin, beta 2 (laminin S)	Gallus gallus	50-57
3678379-0	1987	The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion.	Catechin	28-40	laminin, beta 2 (laminin S)	Gallus gallus	86-93
3678379-5	1987	(+)-Catechin binds to laminin in a pH-dependent way.	Catechin	0-12	laminin, beta 2 (laminin S)	Gallus gallus	22-29
3678379-6	1987	Pretreatment of laminin-coated coverslips or amnion basement membrane with 0.5 mM (+)-catechin abrogates the effect of laminin on cell morphology and adhesion.	Catechin	82-94	laminin, beta 2 (laminin S)	Gallus gallus	16-23
3678379-6	1987	Pretreatment of laminin-coated coverslips or amnion basement membrane with 0.5 mM (+)-catechin abrogates the effect of laminin on cell morphology and adhesion.	Catechin	82-94	laminin, beta 2 (laminin S)	Gallus gallus	119-126
6568822-1	1984	Procyanidol oligomers and (+) catechin bound to insoluble elastin markedly affect its rate of degradation by elastases.	Catechin	30-38	elastin	Homo sapiens	58-65
4016737-3	1985	In vitro addition of (+)-catechin gave rise to a dose-dependent inhibition of the cytochrome P-450-dependent benzphetamine N-demethylase and ethoxyresorufin O-deethylase activities.	Catechin	21-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	82-98
4016737-6	1985	It is concluded that the (+)-catechin inhibits the mutagenicity of aromatic amines in the Ames test by interfering with their cytochrome P-450-dependent bioactivation and by direct interaction with the proximate carcinogen, but the former mechanism is unlikely to occur in vivo because the high doses of the flavonoid required are not achieved.	Catechin	25-37	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	126-142
3983470-5	1985	Increase of hydrogen peroxide formation occurred at the same (+)-cyanidanol-3 concentrations that were capable to inhibit lipid peroxidation, suggesting that the interference of (+)-cyanidanol-3 with the oxidase function of cytochrome P-450 does not compromise its antioxidative activity towards lipid peroxidation.	Catechin	61-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	224-240
3983470-5	1985	Increase of hydrogen peroxide formation occurred at the same (+)-cyanidanol-3 concentrations that were capable to inhibit lipid peroxidation, suggesting that the interference of (+)-cyanidanol-3 with the oxidase function of cytochrome P-450 does not compromise its antioxidative activity towards lipid peroxidation.	Catechin	178-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	224-240
3475069-2	1987	Cyanidin 3-rutinoside, a simple anthocyanin, (+)-catechin, a flavanol, and carmoisine, a synthetic food colorant, were found to be particularly potent, reversible inhibitors of PST P. All inhibited this enzyme by 100% at a concentration of 5 microM and had an IC50 in the microM range.	Catechin	45-57	sulfotransferase family 1A member 1	Homo sapiens	177-180
3032668-1	1987	Treatment of reconstituted collagen fibrils and pieces of rat dermis with the crude extract, purified tannins or (+)-catechin from betel nut (Areca catechu) increases their resistance to both human and bacterial collagenases in a concentration-dependent manner.	Catechin	113-125	NUT midline carcinoma, family member 1	Rattus norvegicus	137-140
3463305-1	1986	A pretreatment with (+)-catechin renders embryonic mouse calvaria in culture resistant to the action of bone resorbing agents, either parathyroid hormone (PTH), prostaglandin E2 or retinoic acid, and inhibits in a parallel way the enhanced excretion of N-acetyl-beta-glucosaminidase, a reference lysosomal enzyme, induced by these agents; it has, however, no effect on the small spontaneous leakage of lactate dehydrogenase from the explants.	Catechin	20-32	parathyroid hormone	Mus musculus	134-153
3463305-1	1986	A pretreatment with (+)-catechin renders embryonic mouse calvaria in culture resistant to the action of bone resorbing agents, either parathyroid hormone (PTH), prostaglandin E2 or retinoic acid, and inhibits in a parallel way the enhanced excretion of N-acetyl-beta-glucosaminidase, a reference lysosomal enzyme, induced by these agents; it has, however, no effect on the small spontaneous leakage of lactate dehydrogenase from the explants.	Catechin	20-32	O-GlcNAcase	Mus musculus	253-282
11540853-7	1985	Other flavonoids such as epicatechin, quercetin and naringenin also inhibited calmodulin-promoted phosphodiesterase activity.	Catechin	25-36	calmodulin1	Zea mays	78-88
11540853-9	1985	Inhibition by catechin and caffeic acid could be reversed by increasing the calmodulin concentration in the assay mixture.	Catechin	14-22	calmodulin1	Zea mays	76-86
11540853-10	1985	Both catechin and caffeic acid inhibited Ca- and calmodulin-promoted phosphorylation of soluble proteins from corn coleoptiles.	Catechin	5-13	calmodulin1	Zea mays	49-59
6568822-4	1984	(+) Catechin-insoluble elastin complexes were partially resistant to the degradation induced by human leukocyte elastase but were hydrolysed at the same rate as untreated samples by a constant amount of pancreatic elastase.	Catechin	4-12	elastin	Homo sapiens	23-30
6618343-8	1983	Cianidanol (KB-53) prevented the decrease of PC-DTH and PPD-DTH in the mice injected with CCl4 and ANIT in a dose-dependent manner, but did not affect DTH in normal mice.	Catechin	0-10	chemokine (C-C motif) ligand 4	Mus musculus	90-94
6311698-1	1983	Protective effects of KB-53 on acute liver injury induced by carbon tetrachloride (CCl4) and 1-naphtylisothiocyanate (ANIT) in mice was investigated by means of histopathological, histochemical and enzymehistochemical examinations.	Catechin	22-27	chemokine (C-C motif) ligand 4	Mus musculus	83-87
6311698-7	1983	In addition, KB-53 inhibited the rise of Al-Pase and total bilirubin in the serum of mice after CCl4 and ANIT-intoxication.	Catechin	13-18	chemokine (C-C motif) ligand 4	Mus musculus	96-100
6618343-8	1983	Cianidanol (KB-53) prevented the decrease of PC-DTH and PPD-DTH in the mice injected with CCl4 and ANIT in a dose-dependent manner, but did not affect DTH in normal mice.	Catechin	12-17	chemokine (C-C motif) ligand 4	Mus musculus	90-94
6311698-8	1983	All these findings suggest that KB-53 protects liver against the morphological and functional changes, and it potentiates the proliferative and regenerative activity of the liver impaired with CCl4 and ANIT.	Catechin	32-37	chemokine (C-C motif) ligand 4	Mus musculus	193-197
6618344-4	1983	In rats with chronically injured liver, plasma GPT and GOT activities were reduced with the administration of cianidanol.	Catechin	110-120	glutamic--pyruvic transaminase	Rattus norvegicus	47-50
6618344-6	1983	These results suggest that cianidanol has the effect of improving the function of liver cells damaged by CCl4 treatment and of promoting the recovery of cell function to a normal level.	Catechin	27-37	C-C motif chemokine ligand 4	Rattus norvegicus	105-109
6618347-0	1983	[Effects of cianidanol (KB-53) on liver cirrhosis induced by CCl4 in rats: a pathological investigation].	Catechin	12-22	C-C motif chemokine ligand 4	Rattus norvegicus	61-65
6618347-0	1983	[Effects of cianidanol (KB-53) on liver cirrhosis induced by CCl4 in rats: a pathological investigation].	Catechin	24-29	C-C motif chemokine ligand 4	Rattus norvegicus	61-65
6618347-1	1983	The therapeutic effects of cianidanol on the rat liver cirrhosis induced by CCl4 were investigated by means of pathological examination.	Catechin	27-37	C-C motif chemokine ligand 4	Rattus norvegicus	76-80
6618347-7	1983	Consequently, it is suggested that cianidanol has therapeutic effects on liver cirrhosis induced by CCl4 by relieving hepatocytes disorder, improving regeneration of hepatocytes and the absorption of proliferated fibrotic tissues.	Catechin	35-45	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
6299080-7	1982	The most effective dose with respect to the reduction of the hydroxyproline concentration was 100 mg/kg (+)-catechin; the highest dose (300 mg/kg), however, enhanced the CCl4-alcohol-induced hydroxyproline augmentation.	Catechin	104-116	C-C motif chemokine ligand 4	Rattus norvegicus	170-174
6891672-4	1982	1%) of purified diets administered to rats for 4 wk, rutin and (+)-catechin increased microsomal cytochrome b5 levels and quercetin and (+)-catechin increased aminopyrine demethylase activity.	Catechin	67-75	cytochrome b5 type A	Rattus norvegicus	97-110
6891672-4	1982	1%) of purified diets administered to rats for 4 wk, rutin and (+)-catechin increased microsomal cytochrome b5 levels and quercetin and (+)-catechin increased aminopyrine demethylase activity.	Catechin	63-75	cytochrome b5 type A	Rattus norvegicus	97-110
6295404-1	1982	About 6-7 (+)-cyanidanol-3 molecules are bound per collagen alpha-chain.	Catechin	10-24	Fc gamma receptor and transporter	Homo sapiens	60-71
7251340-1	1981	In rats treated with (+)-catechin or 0-(beta-hydroxyethyl) rutosides, the activity of lysosomal acid hydrolase, namely, beta-glucuronidase, beta-N-acetyl glucosaminidase and cathepsin D in serum, liver and kidney and the stability of liver lysosomes was studied.	Catechin	21-33	glucuronidase, beta	Rattus norvegicus	120-138
871094-0	1977	Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro.	Catechin	104-116	histidine decarboxylase	Rattus norvegicus	143-166
7251340-1	1981	In rats treated with (+)-catechin or 0-(beta-hydroxyethyl) rutosides, the activity of lysosomal acid hydrolase, namely, beta-glucuronidase, beta-N-acetyl glucosaminidase and cathepsin D in serum, liver and kidney and the stability of liver lysosomes was studied.	Catechin	21-33	cathepsin D	Rattus norvegicus	174-185
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	19-27	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-56
32900230-0	2021	The impact of catechins included in high fat diet on AMP-dependent protein kinase in apoE knock-out mice.	Catechin	14-23	apolipoprotein E	Mus musculus	85-89
33898851-3	2021	We found that CS is rich in protein, lipids, dietary fiber (48.1 +- 0.3 g 100 gdw -1), and antioxidant molecules such as epicatechin (1.10 +- 0.02 mg g-1) and isoquercetin (1.04 +- 0.09 mg g-1).	Catechin	121-132	citrate synthase	Homo sapiens	14-16
871094-5	1977	Since histamine was suggested to be involved in the pathogenesis of stress ulcer disease, (+)-catechin, a rather specific inhibitor of specific histidine decarboxylase from rat stomach, was tested in immobilized rats.	Catechin	90-102	histidine decarboxylase	Rattus norvegicus	144-167
20673-1	1976	(+)--Cyanidanol, a water-soluble flavonoid, when added to cultured skin fibroblasts of a patient with I-cell disease raised the intracellular concentration of beta-galactosidase but did not affect the distribution of <protein-id="410">arylsulfatase.	Catechin	0-15	galactosidase beta 1	Homo sapiens	159-177
33545599-7	2021	This study provides novel insights into the mechanism of catechins as tyrosinase inhibitors.	Catechin	57-66	tyrosinase	Homo sapiens	70-80
34054246-6	2022	Epigallocatechin, Catechins, and Curcumin also exhibited high binding affinity (Docking score -7.3, -7.1 and -7.1 kcal/mol) with the Mpro.	Catechin	18-27	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	133-137
34022705-7	2021	Among the commercially available 10 components presented in Rhei Radix et Rhizoma, gallic acid, (+)-catechin and epicatechin exhibited the strongest inhibitory effect on alpha-glucosidase.	Catechin	100-108	sucrase-isomaltase	Homo sapiens	170-187
34022705-7	2021	Among the commercially available 10 components presented in Rhei Radix et Rhizoma, gallic acid, (+)-catechin and epicatechin exhibited the strongest inhibitory effect on alpha-glucosidase.	Catechin	113-124	sucrase-isomaltase	Homo sapiens	170-187
33749495-6	2021	The green tea catechin EGCG can suppress TLR4 expression.	Catechin	14-22	toll like receptor 4	Homo sapiens	41-45
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	19-27	angiotensin converting enzyme 2	Homo sapiens	82-86
33834197-0	2021	Experimental Evidence that (-)-Epicatechin and Anthocyanins Modulate Glucagon-Like Peptide-1 Metabolism: Relevant For Humans?	Catechin	27-42	glucagon	Homo sapiens	69-92
33733926-3	2021	Additionally, GLUT4, AKT2 and AMPK were docked with catechin, epicatechin, kaempferol, metformin, quercetin and ursolic acid reportedly present in Potentilla fulgens.	Catechin	52-60	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	14-19
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Catechin	32-40	vitronectin	Homo sapiens	91-100
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Catechin	32-40	angiotensin converting enzyme 2	Homo sapiens	105-110
33386025-5	2021	Further, the molecular interactions determined by molecular dynamics simulation revealed that among the 75 drug molecules, catechin can effectively bind to 3CLpro, CTSL, RBD of S protein, NSP6 and nucleocapsid protein.	Catechin	123-131	cathepsin L	Homo sapiens	164-168
33386025-5	2021	Further, the molecular interactions determined by molecular dynamics simulation revealed that among the 75 drug molecules, catechin can effectively bind to 3CLpro, CTSL, RBD of S protein, NSP6 and nucleocapsid protein.	Catechin	123-131	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	166-167
33733926-3	2021	Additionally, GLUT4, AKT2 and AMPK were docked with catechin, epicatechin, kaempferol, metformin, quercetin and ursolic acid reportedly present in Potentilla fulgens.	Catechin	62-73	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	14-19
33693759-13	2021	Cyanidin, delphinidin, PCA, and EC promoted GLP-1 secretion from GLUTag cells by activating the PKA-dependent pathway.	Catechin	32-34	glucagon	Mus musculus	44-49
32770567-6	2021	In the current study we demonstrated by bioinformatics (CASTp: computed atlas of surface topography of protein, PyMol: molecular visualization) and molecular docking (PatchDock and Autodock) experiments that tea flavonoids catechin products mainly epigallocatechin gallate or other like theaflavin gallate demonstrated higher atomic contact energy (ACE) value, binding energy, Ki value, ligand efficiency, surface area and more amino acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike protein.	Catechin	223-231	calpastatin	Homo sapiens	56-61
33693759-0	2021	(-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells.	Catechin	0-15	glucagon	Mus musculus	42-47
33693759-11	2021	In GLUTag cells, 1) cyanidin, delphinidin, PCA, and EC increased GLP-1 secretion (53%, 33%, 53%, and 68%, respectively; P < 0.05); and 2) cyanidin, delphinidin, EC, and PCA increased cyclin adenosine monophosphate levels (25-50%; P < 0.05) and activated protein kinase A (PKA; 100%, 50%, 80%, and 86%, respectively; P < 0.05).	Catechin	52-54	glucagon	Mus musculus	65-70
33693759-11	2021	In GLUTag cells, 1) cyanidin, delphinidin, PCA, and EC increased GLP-1 secretion (53%, 33%, 53%, and 68%, respectively; P < 0.05); and 2) cyanidin, delphinidin, EC, and PCA increased cyclin adenosine monophosphate levels (25-50%; P < 0.05) and activated protein kinase A (PKA; 100%, 50%, 80%, and 86%, respectively; P < 0.05).	Catechin	52-54	proliferating cell nuclear antigen	Mus musculus	183-189
33693759-12	2021	CONCLUSIONS: In mice, EC and ACs regulated different steps in GLP-1 regulation, leading to increased plasma GLP-1.	Catechin	22-24	glucagon	Mus musculus	62-67
33693759-12	2021	CONCLUSIONS: In mice, EC and ACs regulated different steps in GLP-1 regulation, leading to increased plasma GLP-1.	Catechin	22-24	glucagon	Mus musculus	108-113
33495803-6	2021	Ultimately, (-)-catechin (compound 522) and licochalcone A (compound 1148) exhibited the highest AMPK activation activity.	Catechin	12-24	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	97-101
33623845-4	2021	In this study, we examined the effects of the tea catechin (-)-epigallocatechin-3-gallate (EGCG) on human (h) and rat (r) OAT1 and OAT3 using the fluorescent organic anion 6-carboxyfluorescein (6-CF) and hOAT1-, hOAT3-, rOat1-, or rOat3-expressing HEK293 cells and on renal elimination of 6-CF in rats.	Catechin	50-58	solute carrier family 22 member 6	Rattus norvegicus	122-126
33642595-8	2021	The functional annotation of 180 key genes at the SNP loci revealed that FLS, UGT, MYB, and WD40 domain-containing proteins, as well as ATP-binding cassette transporters, may be important for catechin synthesis.	Catechin	192-200	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	78-81
33642595-8	2021	The functional annotation of 180 key genes at the SNP loci revealed that FLS, UGT, MYB, and WD40 domain-containing proteins, as well as ATP-binding cassette transporters, may be important for catechin synthesis.	Catechin	192-200	MYB proto-oncogene, transcription factor	Homo sapiens	83-86
33681501-5	2021	In this study, we investigate the effect of catechins on plasma membrane Ca2+-ATPase (PMCA), which is one of the main mechanisms that extrude Ca2+ out of the cell.	Catechin	44-53	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	57-84
33681501-5	2021	In this study, we investigate the effect of catechins on plasma membrane Ca2+-ATPase (PMCA), which is one of the main mechanisms that extrude Ca2+ out of the cell.	Catechin	44-53	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	86-90
33681501-7	2021	Among catechins that inhibited PMCA activity, the most potent inhibitor was EGCG.	Catechin	6-15	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	31-35
33569875-0	2021	New insights into the role of the Nrf2 signaling pathway in green tea catechin applications.	Catechin	70-78	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
33569875-4	2021	In this review, we attempted to focus on intervention between green tea catechins and Nrf2.	Catechin	72-81	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	kelch like ECH associated protein 1	Homo sapiens	160-166
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	heme oxygenase 1	Homo sapiens	168-172
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	NAD(P)H quinone dehydrogenase 1	Homo sapiens	174-179
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	glutamate-cysteine ligase catalytic subunit	Homo sapiens	186-190
33569875-5	2021	Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins.	Catechin	10-19	glutamate-cysteine ligase modifier subunit	Homo sapiens	192-196
33569875-6	2021	Subsequently, we compiled an updated expansions of the Nrf2 role as a gate to manage and protect different disorders and feasible indications of green tea catechins through this signaling pathway.	Catechin	155-164	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
32770567-6	2021	In the current study we demonstrated by bioinformatics (CASTp: computed atlas of surface topography of protein, PyMol: molecular visualization) and molecular docking (PatchDock and Autodock) experiments that tea flavonoids catechin products mainly epigallocatechin gallate or other like theaflavin gallate demonstrated higher atomic contact energy (ACE) value, binding energy, Ki value, ligand efficiency, surface area and more amino acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike protein.	Catechin	223-231	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	527-532
33467104-1	2021	Flavocoxid is a blended extract containing baicalin and catechin with potent antioxidant and anti-inflammatory properties due to the inhibition of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes, nuclear factor-kappaB (NF-kappaB), tumor necrosis factor (TNF)-alpha, and the mitogen-activated protein kinases (MAPKs) pathways.	Catechin	56-64	tumor necrosis factor	Homo sapiens	243-276
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	0-8	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	36-37
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	0-8	angiotensin converting enzyme 2	Homo sapiens	63-67
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	130-131
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	158-162
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-232
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Catechin	31-39	angiotensin converting enzyme 2	Homo sapiens	72-76
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Catechin	31-39	angiotensin converting enzyme 2	Homo sapiens	85-89
33479401-8	2021	Contrary to this, catechin binds with amino acid residues present near the RBD site of S Protein and causes fluctuation in the amino acid residues of the RBD and its near proximity.	Catechin	18-26	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	87-88
33479401-9	2021	Both catechin and curcumin bind the interface of "RBD/ACE2-complex" and intervene in causing fluctuation of the alpha helices and beta-strands of the protein complex.	Catechin	5-13	angiotensin converting enzyme 2	Homo sapiens	54-58
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Catechin	63-71	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Catechin	63-71	angiotensin converting enzyme 2	Homo sapiens	197-201
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Catechin	31-39	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	61-62
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	Catechin	55-64	sucrase-isomaltase	Homo sapiens	89-106
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	Catechin	218-227	sucrase-isomaltase	Homo sapiens	43-60
33840685-2	2021	We previously reported that TRPA1 and TRPV1 channels expressed in the oral cavity of mammals, are activated by the auto-oxidized product of epigallocatechin gallate (oxiEGCG), a major astringent catechin in green tea.	Catechin	148-156	transient receptor potential cation channel subfamily A member 1	Homo sapiens	28-33
33840685-2	2021	We previously reported that TRPA1 and TRPV1 channels expressed in the oral cavity of mammals, are activated by the auto-oxidized product of epigallocatechin gallate (oxiEGCG), a major astringent catechin in green tea.	Catechin	148-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	38-43
33270240-2	2021	AEG showed antioxidant activity in the DPPH  scavenging (IC50  = 17.00 +- 1.00 microg/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols).	Catechin	177-186	cysteine-rich secretory protein 3	Rattus norvegicus	0-3
33017609-7	2021	In silico molecular docking analysis predicted a model where galloylated catechins may bind TGF-betaR1 within its adenosine triphosphate (ATP) binding cleft in a site analogous to that of Galunisertib, a selective ATP-mimetic competitive inhibitor of TGF-betaR1.	Catechin	73-82	transcription factor 20	Homo sapiens	96-102
33017609-8	2021	In conclusion, our data suggest that the galloyl moiety of the diet-derived catechins provides specificity of action to galloylated catechins by positioning them within the kinase domain of the TGF-betaR1 in order to antagonize TGF-beta-mediated signaling that is required for ovarian cancer cell invasion and metastasis.	Catechin	76-85	transforming growth factor alpha	Homo sapiens	194-202
33017609-8	2021	In conclusion, our data suggest that the galloyl moiety of the diet-derived catechins provides specificity of action to galloylated catechins by positioning them within the kinase domain of the TGF-betaR1 in order to antagonize TGF-beta-mediated signaling that is required for ovarian cancer cell invasion and metastasis.	Catechin	132-141	transforming growth factor alpha	Homo sapiens	194-202
33249742-1	2021	SCOPE: Catechin-rich green tea extract (GTE) limits inflammation in nonalcoholic steatohepatitis (NASH) consistent with a Toll-like receptor 4 (TLR4)-dependent mechanism.	Catechin	7-15	toll-like receptor 4	Mus musculus	122-142
33249742-1	2021	SCOPE: Catechin-rich green tea extract (GTE) limits inflammation in nonalcoholic steatohepatitis (NASH) consistent with a Toll-like receptor 4 (TLR4)-dependent mechanism.	Catechin	7-15	toll-like receptor 4	Mus musculus	144-148
32126843-0	2021	Diet-Derived Gallated Catechins Prevent TGF-beta-Mediated Epithelial-Mesenchymal Transition, Cell Migration and Vasculogenic Mimicry in Chemosensitive ES-2 Ovarian Cancer Cells.	Catechin	22-31	transforming growth factor alpha	Homo sapiens	40-48
33231155-0	2022	Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking studies unveils an opportunity against CORONA.	Catechin	0-8	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	61-65
32126843-5	2021	Catechins bearing the galloyl moiety (CG, ECG, GCG, and EGCG) exerted potent inhibition of TGF-beta-induced cell migration as well as EMT, and inhibited VM, in part through inhibition of Snail and matrix metalloproteinase-2 secretion.Conclusions: Our data suggest that diet-derived catechins exhibit chemopreventive properties that circumvent the TGF-beta-mediated signaling which contributes to the ovarian cancer metastatic phenotype.	Catechin	0-9	transforming growth factor alpha	Homo sapiens	91-99
32126843-5	2021	Catechins bearing the galloyl moiety (CG, ECG, GCG, and EGCG) exerted potent inhibition of TGF-beta-induced cell migration as well as EMT, and inhibited VM, in part through inhibition of Snail and matrix metalloproteinase-2 secretion.Conclusions: Our data suggest that diet-derived catechins exhibit chemopreventive properties that circumvent the TGF-beta-mediated signaling which contributes to the ovarian cancer metastatic phenotype.	Catechin	0-9	snail family transcriptional repressor 1	Homo sapiens	187-192
32126843-5	2021	Catechins bearing the galloyl moiety (CG, ECG, GCG, and EGCG) exerted potent inhibition of TGF-beta-induced cell migration as well as EMT, and inhibited VM, in part through inhibition of Snail and matrix metalloproteinase-2 secretion.Conclusions: Our data suggest that diet-derived catechins exhibit chemopreventive properties that circumvent the TGF-beta-mediated signaling which contributes to the ovarian cancer metastatic phenotype.	Catechin	0-9	matrix metallopeptidase 2	Homo sapiens	197-223
32126843-5	2021	Catechins bearing the galloyl moiety (CG, ECG, GCG, and EGCG) exerted potent inhibition of TGF-beta-induced cell migration as well as EMT, and inhibited VM, in part through inhibition of Snail and matrix metalloproteinase-2 secretion.Conclusions: Our data suggest that diet-derived catechins exhibit chemopreventive properties that circumvent the TGF-beta-mediated signaling which contributes to the ovarian cancer metastatic phenotype.	Catechin	0-9	transforming growth factor alpha	Homo sapiens	347-355
32126843-5	2021	Catechins bearing the galloyl moiety (CG, ECG, GCG, and EGCG) exerted potent inhibition of TGF-beta-induced cell migration as well as EMT, and inhibited VM, in part through inhibition of Snail and matrix metalloproteinase-2 secretion.Conclusions: Our data suggest that diet-derived catechins exhibit chemopreventive properties that circumvent the TGF-beta-mediated signaling which contributes to the ovarian cancer metastatic phenotype.	Catechin	282-291	transforming growth factor alpha	Homo sapiens	91-99
33302853-0	2021	Silybin B and Cianidanol Inhibit M pro and Spike Protein of SARS-CoV-2: Evidence from in Silico Molecular Docking Studies.	Catechin	14-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	43-48
33137558-6	2020	The results demonstrate that green tea catechins EGC and ECG are able to alleviate the toxicity of Abeta oligomers and fibrils.	Catechin	39-48	amyloid beta (A4) precursor protein	Mus musculus	99-104
32725283-8	2020	In vitro, catechin inhibited both MAO isoforms at concentrations of 0.34 and 1.03 mM being completely reversible for MAO-A and partially reversible for MAO-B.	Catechin	10-18	monoamine oxidase B	Mus musculus	152-157
32725283-9	2020	Molecular docking indicated that the catechin bound in the active site of MAO-A, while in the MAO-B it interacted with the surface of the enzyme in an allosteric site.	Catechin	37-45	monoamine oxidase A	Mus musculus	74-79
32725283-9	2020	Molecular docking indicated that the catechin bound in the active site of MAO-A, while in the MAO-B it interacted with the surface of the enzyme in an allosteric site.	Catechin	37-45	monoamine oxidase B	Mus musculus	94-99
33266280-4	2020	Here, we present the effect of selected green tea catechins on enzymatic activity of PTP1B phosphatase and viability of MCF-7 breast cancer cells.	Catechin	50-59	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	85-90
33266280-5	2020	We showed also the computational analysis of the most effective catechin binding with a PTP1B molecule.	Catechin	64-72	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	88-93
33266280-6	2020	We observed that epigallocatechin, epigallocatechin gallate, epicatechin, and epicatechin gallate may decrease enzymatic activity of PTP1B phosphatase and viability of MCF-7 cells.	Catechin	61-72	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	133-138
33292347-0	2020	Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice.	Catechin	0-9	signal transducer and activator of transcription 3	Mus musculus	64-69
33292347-9	2020	RESULTS: Catechins could effectively reduce the ovarian and uterine organ coefficients, reduce the levels of E2, FSH and LH in the blood and the ratio of LH/FSH, and improve glucose metabolism and insulin resistance in PCOS mice induced by insulin combined with hCG.	Catechin	9-18	follicle stimulating hormone beta	Mus musculus	113-116
33292347-9	2020	RESULTS: Catechins could effectively reduce the ovarian and uterine organ coefficients, reduce the levels of E2, FSH and LH in the blood and the ratio of LH/FSH, and improve glucose metabolism and insulin resistance in PCOS mice induced by insulin combined with hCG.	Catechin	9-18	follicle stimulating hormone beta	Mus musculus	157-160
33292347-10	2020	In addition, catechins could significantly down-regulated the expression of p-NF-kappaB p65 in the uterus and the protein expressions of the pro-inflammatory factors (IL-1beta, IL-6, and TNF-alpha).	Catechin	13-22	interleukin 1 alpha	Mus musculus	167-175
33292347-10	2020	In addition, catechins could significantly down-regulated the expression of p-NF-kappaB p65 in the uterus and the protein expressions of the pro-inflammatory factors (IL-1beta, IL-6, and TNF-alpha).	Catechin	13-22	interleukin 6	Mus musculus	177-181
33292347-10	2020	In addition, catechins could significantly down-regulated the expression of p-NF-kappaB p65 in the uterus and the protein expressions of the pro-inflammatory factors (IL-1beta, IL-6, and TNF-alpha).	Catechin	13-22	tumor necrosis factor	Mus musculus	187-196
33292347-11	2020	The expressions of mmp2 and mmp9 associated with matrix degradation in uterine tissue were also significantly down-regulated by catechins.	Catechin	128-137	matrix metallopeptidase 2	Mus musculus	19-23
33292347-11	2020	The expressions of mmp2 and mmp9 associated with matrix degradation in uterine tissue were also significantly down-regulated by catechins.	Catechin	128-137	matrix metallopeptidase 9	Mus musculus	28-32
33292347-12	2020	Further, catechins significantly reduced the expression of p-STAT3 and increased the expression of p-IRS1 and p-PI3K in the uterus of PCOS mice.	Catechin	9-18	signal transducer and activator of transcription 3	Mus musculus	61-66
33292347-12	2020	Further, catechins significantly reduced the expression of p-STAT3 and increased the expression of p-IRS1 and p-PI3K in the uterus of PCOS mice.	Catechin	9-18	insulin receptor substrate 1	Mus musculus	101-105
33292347-13	2020	CONCLUSION: Catechins from oolong tea can alleviate ovarian dysfunction and insulin resistance in PCOS mice by inhibiting uterine inflammation and matrix degradation via inhibiting p-STAT3 signaling.	Catechin	12-21	signal transducer and activator of transcription 3	Mus musculus	183-188
33505939-3	2020	The catechin/HP-beta-CD complex exhibited the highest encapsulation efficiency (83.37%), followed by epicatechin/HP-beta-CD (81.51%), morin hydrate/HP-beta-CD (81.38%), and quercetin/HP-beta-CD (81.16%).	Catechin	4-12	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	16-23
33368058-9	2020	Two molecules, curcumin and catechin, bind directly to the receptor-binding domain of the S-protein and the angiotensin-converting enzyme 2 receptor of the host cell, by which these molecules inhibit the entry of viruses in the host cell.	Catechin	28-36	vitronectin	Homo sapiens	90-99
32725283-2	2020	The potential modulation of monoaminoxidase (MAO) activity, tyrosine hydroxylase (TH) and glutamic acid decarboxylase (GAD67) immunoreactivity by catechin were used as biochemical endpoints.	Catechin	146-154	tyrosine hydroxylase	Mus musculus	60-80
32725283-2	2020	The potential modulation of monoaminoxidase (MAO) activity, tyrosine hydroxylase (TH) and glutamic acid decarboxylase (GAD67) immunoreactivity by catechin were used as biochemical endpoints.	Catechin	146-154	tyrosine hydroxylase	Mus musculus	82-84
32725283-3	2020	The interaction of catechin with MAO-A and MAO-B was determined in vitro and in silico.	Catechin	19-27	monoamine oxidase A	Mus musculus	33-38
32725283-3	2020	The interaction of catechin with MAO-A and MAO-B was determined in vitro and in silico.	Catechin	19-27	monoamine oxidase B	Mus musculus	43-48
32725283-8	2020	In vitro, catechin inhibited both MAO isoforms at concentrations of 0.34 and 1.03 mM being completely reversible for MAO-A and partially reversible for MAO-B.	Catechin	10-18	monoamine oxidase A	Mus musculus	117-122
33329667-6	2020	In vitro analysis with 10 available compounds showed that CAG, ECG, GCG, EGCG, and PB2 inhibited the Mpro activity with an IC50 value, 2.98 +- 0.21, 5.21 +- 0.5, 6.38 +- 0.5, 7.51 +- 0.21, and 75.3 +- 1.29 muM, respectively, while CA, EC, EGC, GC, and PA2 did not have inhibitory activities.	Catechin	63-65	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	101-105
33231155-7	2022	COVID-19 main protease Mpro was docked with catechin and its different synthetic derivatives.	Catechin	44-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	23-27
33163657-0	2020	PXR is a target of (-)-epicatechin in skeletal muscle.	Catechin	19-34	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
33251444-4	2020	To facilitate the understanding of regioisomer/stereoisomer-specific biological effects of (epi)catechin glucuronides, we here describe a concise chemical synthesis of authentic standards of catechin and epicatechin metabolites 3-12.	Catechin	96-104	tissue factor pathway inhibitor	Homo sapiens	92-95
33251444-4	2020	To facilitate the understanding of regioisomer/stereoisomer-specific biological effects of (epi)catechin glucuronides, we here describe a concise chemical synthesis of authentic standards of catechin and epicatechin metabolites 3-12.	Catechin	204-215	tissue factor pathway inhibitor	Homo sapiens	92-95
33251444-6	2020	The key reactions employed in the synthesis of the novel glucuronides 9 and 12 include the regioselective methylation of the 4"-hydroxyl group of (epi)catechin (<=1.0/99.0%; 3"-OMe/4"-OMe) and the regioselective deprotection of the tert-butyldimethylsilyl (TBS) group at position 5 (yielding up to 79%) over the others (3, 7 and 3" or 4").	Catechin	151-159	tissue factor pathway inhibitor	Homo sapiens	147-150
32673708-18	2020	In-silico experiment exhibited Cianidanol (-17.133), epicatechin (-15.107) exhibited higher docking score against PPARalpha and luteoforol (-11.038), epigallocatechin (-10.736) against PPARgamma.	Catechin	31-41	peroxisome proliferator activated receptor alpha	Rattus norvegicus	114-123
32673708-18	2020	In-silico experiment exhibited Cianidanol (-17.133), epicatechin (-15.107) exhibited higher docking score against PPARalpha and luteoforol (-11.038), epigallocatechin (-10.736) against PPARgamma.	Catechin	31-41	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	185-194
32673708-18	2020	In-silico experiment exhibited Cianidanol (-17.133), epicatechin (-15.107) exhibited higher docking score against PPARalpha and luteoforol (-11.038), epigallocatechin (-10.736) against PPARgamma.	Catechin	53-64	peroxisome proliferator activated receptor alpha	Rattus norvegicus	114-123
32673708-18	2020	In-silico experiment exhibited Cianidanol (-17.133), epicatechin (-15.107) exhibited higher docking score against PPARalpha and luteoforol (-11.038), epigallocatechin (-10.736) against PPARgamma.	Catechin	53-64	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	185-194
32673708-20	2020	Cianidanol and epigallocatechin out of the 30 compounds are concluded as a potential candidate for the treatment of DN through activating PPARalpha and PPARgamma target protein.	Catechin	0-10	peroxisome proliferator activated receptor alpha	Rattus norvegicus	138-147
32673708-20	2020	Cianidanol and epigallocatechin out of the 30 compounds are concluded as a potential candidate for the treatment of DN through activating PPARalpha and PPARgamma target protein.	Catechin	0-10	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	152-161
33207822-7	2020	Catechin effects can be directly exerted on pre-osteoclasts/osteoclasts or indirectly exerted via the modulation of mesenchymal stem cells (MSCs)/stromal cell regulation of pre-osteoclasts through activation of the nuclear factor kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system.	Catechin	0-8	TNF superfamily member 11	Homo sapiens	253-258
33207822-7	2020	Catechin effects can be directly exerted on pre-osteoclasts/osteoclasts or indirectly exerted via the modulation of mesenchymal stem cells (MSCs)/stromal cell regulation of pre-osteoclasts through activation of the nuclear factor kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system.	Catechin	0-8	TNF receptor superfamily member 11b	Homo sapiens	260-275
33207822-7	2020	Catechin effects can be directly exerted on pre-osteoclasts/osteoclasts or indirectly exerted via the modulation of mesenchymal stem cells (MSCs)/stromal cell regulation of pre-osteoclasts through activation of the nuclear factor kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system.	Catechin	0-8	TNF receptor superfamily member 11b	Homo sapiens	277-280
33151476-7	2020	FOXO1a increased in spinal cord injury group vs Sham (-)-epicatechin reduced this increase.	Catechin	57-68	forkhead box O1	Mus musculus	0-6
33151476-8	2020	In spinal cord injury group MAFbx increased significantly vs Sham but decrease in (-)-epicatechin treatment group at 30 days.	Catechin	86-97	F-box protein 32	Mus musculus	28-33
33151476-9	2020	At 7 and 30 days MuRF1 increased in the spinal cord injury and decreased in the (-)-epicatechin group.	Catechin	84-95	tripartite motif-containing 63	Mus musculus	17-22
33163657-3	2020	We hypothesize that the pregnane X receptor (PXR) can fulfill those characteristics, based on structural similitude between EC and steroidal backbone and that PXR activation leads to similar effects as those induced by EC.	Catechin	124-126	nuclear receptor subfamily 1, group I, member 2	Mus musculus	24-43
33163657-3	2020	We hypothesize that the pregnane X receptor (PXR) can fulfill those characteristics, based on structural similitude between EC and steroidal backbone and that PXR activation leads to similar effects as those induced by EC.	Catechin	124-126	nuclear receptor subfamily 1, group I, member 2	Mus musculus	45-48
33163657-5	2020	(-)-Epicatechin interacts and activates PXR, promoting this protein translocation to the nucleus, increasing the expression of Cyp3a11, and promoting C2C12 cell differentiation through increasing myogenin expression.	Catechin	4-15	nuclear receptor subfamily 1, group I, member 2	Mus musculus	40-43
33163657-5	2020	(-)-Epicatechin interacts and activates PXR, promoting this protein translocation to the nucleus, increasing the expression of Cyp3a11, and promoting C2C12 cell differentiation through increasing myogenin expression.	Catechin	4-15	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	127-134
33163657-5	2020	(-)-Epicatechin interacts and activates PXR, promoting this protein translocation to the nucleus, increasing the expression of Cyp3a11, and promoting C2C12 cell differentiation through increasing myogenin expression.	Catechin	4-15	myogenin	Mus musculus	196-204
33163657-6	2020	These results can be the base of further studies to analyze the possible participation of PXR in the skeletal muscle effects shown by EC.	Catechin	134-136	nuclear receptor subfamily 1, group I, member 2	Mus musculus	90-93
32959859-6	2020	Thus, in EC and DHBA pre-treated cells ICAM-1, p-ERK and p-JNK were returned to control values, and VCAM-1 and p-p38 levels were reduced by ~20 and 25%, respectively, when compared to high glucose plus LPS-stimulated cells.	Catechin	9-11	intercellular adhesion molecule 1	Rattus norvegicus	39-45
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	tumor necrosis factor	Rattus norvegicus	146-155
32959859-0	2020	(-)-Epicatechin and the colonic metabolite 2,3-dihydroxybenzoic acid protect against high glucose and lipopolysaccharide-induced inflammation in renal proximal tubular cells through NOX-4/p38 signalling.	Catechin	0-15	NADPH oxidase 4	Rattus norvegicus	182-187
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	interleukin 6	Rattus norvegicus	158-171
32959859-9	2020	Taken together, EC and DHBA exert beneficial effects in renal proximal tubular cells, as they contribute to preventing the inflammatory-induced milieu and the accompanying redox imbalance, playing NOX-4/p38 a crucial role.	Catechin	16-18	NADPH oxidase 4	Rattus norvegicus	197-202
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	interleukin 6	Rattus norvegicus	173-177
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	C-C motif chemokine ligand 2	Rattus norvegicus	183-217
32959859-4	2020	Pre-treatment of cells with EC and DHBA (5 muM) reverted the enhanced levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1), activated by high glucose and LPS.	Catechin	28-30	C-C motif chemokine ligand 2	Rattus norvegicus	219-224
32959859-0	2020	(-)-Epicatechin and the colonic metabolite 2,3-dihydroxybenzoic acid protect against high glucose and lipopolysaccharide-induced inflammation in renal proximal tubular cells through NOX-4/p38 signalling.	Catechin	0-15	mitogen activated protein kinase 14	Rattus norvegicus	188-191
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	intercellular adhesion molecule 1	Rattus norvegicus	101-139
32959859-9	2020	Taken together, EC and DHBA exert beneficial effects in renal proximal tubular cells, as they contribute to preventing the inflammatory-induced milieu and the accompanying redox imbalance, playing NOX-4/p38 a crucial role.	Catechin	16-18	mitogen activated protein kinase 14	Rattus norvegicus	203-206
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	intercellular adhesion molecule 1	Rattus norvegicus	141-147
33066504-4	2020	As shown by intervention studies on volunteers, the most promising candidates for improving insulin resistance are (-)-epicatechin, (-)-epicatechin-containing foods and anthocyanins.	Catechin	115-130	insulin	Homo sapiens	92-99
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	vascular cell adhesion molecule 1	Rattus norvegicus	153-186
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	vascular cell adhesion molecule 1	Rattus norvegicus	188-194
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	Eph receptor B1	Rattus norvegicus	260-297
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	Eph receptor B1	Rattus norvegicus	299-302
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	mitogen-activated protein kinase 8	Rattus norvegicus	305-329
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	mitogen-activated protein kinase 8	Rattus norvegicus	331-334
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	mitogen activated protein kinase 14	Rattus norvegicus	341-344
32959859-5	2020	Additionally, EC and DHBA pre-incubation reduced the increased values of adhesion molecules, namely, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), as well as those of mitogen-activated protein kinases (MAPKs) [extracellular signal-regulated kinase (ERK), -c-jun N-terminal kinase (JNK) and -p38 protein kinase (p38)] activated by the high glucose and LPS challenge.	Catechin	14-16	mitogen activated protein kinase 14	Rattus norvegicus	361-364
32959859-6	2020	Thus, in EC and DHBA pre-treated cells ICAM-1, p-ERK and p-JNK were returned to control values, and VCAM-1 and p-p38 levels were reduced by ~20 and 25%, respectively, when compared to high glucose plus LPS-stimulated cells.	Catechin	9-11	Eph receptor B1	Rattus norvegicus	49-52
32959859-6	2020	Thus, in EC and DHBA pre-treated cells ICAM-1, p-ERK and p-JNK were returned to control values, and VCAM-1 and p-p38 levels were reduced by ~20 and 25%, respectively, when compared to high glucose plus LPS-stimulated cells.	Catechin	9-11	mitogen-activated protein kinase 8	Rattus norvegicus	59-62
32959859-6	2020	Thus, in EC and DHBA pre-treated cells ICAM-1, p-ERK and p-JNK were returned to control values, and VCAM-1 and p-p38 levels were reduced by ~20 and 25%, respectively, when compared to high glucose plus LPS-stimulated cells.	Catechin	9-11	vascular cell adhesion molecule 1	Rattus norvegicus	100-106
32959859-6	2020	Thus, in EC and DHBA pre-treated cells ICAM-1, p-ERK and p-JNK were returned to control values, and VCAM-1 and p-p38 levels were reduced by ~20 and 25%, respectively, when compared to high glucose plus LPS-stimulated cells.	Catechin	9-11	mitogen activated protein kinase 14	Rattus norvegicus	113-116
32959859-7	2020	Likewise, pre-treatment with EC and DHBA protected against high glucose plus LPS-triggered oxidative stress by preventing increased ROS and NADPH oxidase 4 (NOX-4) levels (~25 and 45% reduction, respectively).	Catechin	29-31	NADPH oxidase 4	Rattus norvegicus	140-155
32959859-7	2020	Likewise, pre-treatment with EC and DHBA protected against high glucose plus LPS-triggered oxidative stress by preventing increased ROS and NADPH oxidase 4 (NOX-4) levels (~25 and 45% reduction, respectively).	Catechin	29-31	NADPH oxidase 4	Rattus norvegicus	157-162
33066025-7	2020	Among the isolates, (-)-catechin suppressed the activity of collagenase MMP-1, and reversed the degradation of collagen induced by tumor necrosis factor-alpha (TNF-alpha) in normal human dermal fibroblast.	Catechin	24-32	matrix metallopeptidase 1	Homo sapiens	72-77
33066504-4	2020	As shown by intervention studies on volunteers, the most promising candidates for improving insulin resistance are (-)-epicatechin, (-)-epicatechin-containing foods and anthocyanins.	Catechin	132-147	insulin	Homo sapiens	92-99
33050575-4	2020	Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the Nrf2/ARE pathway in both normal and cancer cells.	Catechin	61-72	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
33066025-7	2020	Among the isolates, (-)-catechin suppressed the activity of collagenase MMP-1, and reversed the degradation of collagen induced by tumor necrosis factor-alpha (TNF-alpha) in normal human dermal fibroblast.	Catechin	24-32	tumor necrosis factor	Homo sapiens	131-158
33066025-7	2020	Among the isolates, (-)-catechin suppressed the activity of collagenase MMP-1, and reversed the degradation of collagen induced by tumor necrosis factor-alpha (TNF-alpha) in normal human dermal fibroblast.	Catechin	24-32	tumor necrosis factor	Homo sapiens	160-169
33066025-8	2020	This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-alpha-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2).	Catechin	29-37	tumor necrosis factor	Homo sapiens	74-101
33066025-8	2020	This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-alpha-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2).	Catechin	29-37	protein tyrosine kinase 2 beta	Homo sapiens	183-199
33066025-8	2020	This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-alpha-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2).	Catechin	29-37	AKT serine/threonine kinase 1	Homo sapiens	201-204
33066025-8	2020	This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-alpha-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2).	Catechin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	211-227
33066025-8	2020	This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-alpha-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2).	Catechin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	229-234
33066025-10	2020	In this milieu, we demonstrated that (-)-catechin decreased the expression and secretion of proinflammatory cytokines, including interleukin (IL)-1beta and IL-6.	Catechin	41-49	interleukin 1 alpha	Homo sapiens	129-151
33066025-10	2020	In this milieu, we demonstrated that (-)-catechin decreased the expression and secretion of proinflammatory cytokines, including interleukin (IL)-1beta and IL-6.	Catechin	41-49	interleukin 6	Homo sapiens	156-160
33072538-2	2020	Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor gamma (PPAR gamma), glucose transporter type 4 (GLUT-4) of (+)-catechin & proanthocyanidin fraction Uncaria gambir Roxb.	Catechin	214-222	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	199-205
32688217-1	2020	Catechin-rich green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by alleviating gut-derived endotoxin translocation and hepatic Toll-like receptor-4 (TLR4)-nuclear factor kappaB (NFkappaB) inflammation.	Catechin	0-8	toll-like receptor 4	Mus musculus	154-174
32688217-1	2020	Catechin-rich green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by alleviating gut-derived endotoxin translocation and hepatic Toll-like receptor-4 (TLR4)-nuclear factor kappaB (NFkappaB) inflammation.	Catechin	0-8	toll-like receptor 4	Mus musculus	176-180
32688217-1	2020	Catechin-rich green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by alleviating gut-derived endotoxin translocation and hepatic Toll-like receptor-4 (TLR4)-nuclear factor kappaB (NFkappaB) inflammation.	Catechin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-213
32992756-10	2020	Epicatechin decreased TG (endogenous thrombin potential, nM.min) from 586 +- 302 to 509 +- 226 (p = 0.3), 512 +- 270 (p = 0.3) and 445 +- 283 (p < 0.05).	Catechin	0-11	coagulation factor II, thrombin	Homo sapiens	37-45
32973337-10	2020	The leucoanthocyanidin reductase 2 gene (LAR2) presented a significant increase of expression in susceptible genotypes, in accordance with catechin accumulation in this analysis group.	Catechin	139-147	leucoanthocyanidin reductase 2	Vitis vinifera	4-34
32973337-10	2020	The leucoanthocyanidin reductase 2 gene (LAR2) presented a significant increase of expression in susceptible genotypes, in accordance with catechin accumulation in this analysis group.	Catechin	139-147	leucoanthocyanidin reductase 2	Vitis vinifera	41-45
32998374-0	2020	Computational and In Vitro Investigation of (-)-Epicatechin and Proanthocyanidin B2 as Inhibitors of Human Matrix Metalloproteinase 1.	Catechin	44-59	matrix metallopeptidase 1	Homo sapiens	107-133
32998374-5	2020	In this study, sequential absorption, distribution, metabolism, and excretion (ADME) profiling, quantum mechanics calculations, and molecular docking simulations by extra precision Glide protocol predicted the drug-likeness of (-)-epicatechin (-7.862 kcal/mol) and proanthocyanidin B2 (-8.145 kcal/mol) with the least reactivity and substantial binding affinity in the catalytic pocket of human MMP-1 by comparison to reference bioactive compound epigallocatechin gallate (-6.488 kcal/mol).	Catechin	227-242	matrix metallopeptidase 1	Homo sapiens	395-400
32998374-9	2020	Altogether with computational and MMP-1-zymography results, our findings support (-)-epicatechin as a comparatively strong inhibitor of human MMP-1 with considerable drug-likeness against proanthocyanidin B2 in reference to epigallocatechin gallate.	Catechin	81-96	matrix metallopeptidase 1	Homo sapiens	34-39
32998374-9	2020	Altogether with computational and MMP-1-zymography results, our findings support (-)-epicatechin as a comparatively strong inhibitor of human MMP-1 with considerable drug-likeness against proanthocyanidin B2 in reference to epigallocatechin gallate.	Catechin	81-96	matrix metallopeptidase 1	Homo sapiens	142-147
33072538-5	2020	The ability of (+) - catechin as an activator of sirtuin-1 was assessed by administration of (+) - catechin with the presence of a specific inhibitor of sirtuin-1, nicotinamide.	Catechin	21-29	sirtuin 1	Mus musculus	49-58
33072538-5	2020	The ability of (+) - catechin as an activator of sirtuin-1 was assessed by administration of (+) - catechin with the presence of a specific inhibitor of sirtuin-1, nicotinamide.	Catechin	21-29	sirtuin 1	Mus musculus	153-162
33072538-5	2020	The ability of (+) - catechin as an activator of sirtuin-1 was assessed by administration of (+) - catechin with the presence of a specific inhibitor of sirtuin-1, nicotinamide.	Catechin	99-107	sirtuin 1	Mus musculus	49-58
32564472-2	2020	In this report, we studied the effects of teas and tea catechins on the small intestinal sugar transporters, SGLT1 and GLUTs (GLUT1, 2 and 5).	Catechin	55-64	solute carrier family 5 member 1	Homo sapiens	109-114
32811367-4	2022	Present in-silico analysis depicted that natural antioxidants like sesamin, ellagic acid, capsaisin, and epicatechin along with galangin, exhibited significant binding at the catalytic site of the Mpro enzyme.	Catechin	105-116	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	197-201
32746771-6	2021	From the investigation of CYP inhibitors against MAOB, five CYP inhibitors- Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin have expressed inhibitory action against MAOB without any interference with Akt1 and Akt2.	Catechin	97-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-29
32746771-6	2021	From the investigation of CYP inhibitors against MAOB, five CYP inhibitors- Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin have expressed inhibitory action against MAOB without any interference with Akt1 and Akt2.	Catechin	97-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	60-63
32746771-6	2021	From the investigation of CYP inhibitors against MAOB, five CYP inhibitors- Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin have expressed inhibitory action against MAOB without any interference with Akt1 and Akt2.	Catechin	97-108	monoamine oxidase B	Homo sapiens	176-180
32454171-4	2020	The results showed that the tea catechins significantly suppressed tyrosinase activity and melanin synthesis in B16F10 cells, where the effects of ECG > EGCG > GCG.	Catechin	32-41	tyrosinase	Mus musculus	67-77
32903408-7	2020	In fact, several polyphenols, catechins, quinones, and peptides obtained from natural sources (including nuts, oils, root extracts, and fungi metabolites) have been described as promising KATi.	Catechin	30-39	kynurenine aminotransferase 1	Homo sapiens	188-192
32746771-7	2021	This study mainly represents that Galuteolin and Linarin in the Akt pathway can be perceived for OSCC treatment and other five CYP inhibitors - Diosmetin, Acacetin, Epicatechin, Eriodictyol and Capillin for the treatment of other diseases and cancers caused by overexpression of MAOB.	Catechin	165-176	AKT serine/threonine kinase 1	Homo sapiens	64-67
32564472-2	2020	In this report, we studied the effects of teas and tea catechins on the small intestinal sugar transporters, SGLT1 and GLUTs (GLUT1, 2 and 5).	Catechin	55-64	solute carrier family 2 member 1	Homo sapiens	126-140
32564472-7	2020	In Caco-2 cells, individual tea catechins reduced the SGLT1 gene, but not protein expression levels.	Catechin	32-41	solute carrier family 5 member 1	Homo sapiens	54-59
32564472-8	2020	In contrast, GLUT2 gene and protein expression levels were reduced after 2 hours exposure to catechins but increased after 24 hours.	Catechin	93-102	solute carrier family 2 member 2	Homo sapiens	13-18
32640594-3	2020	Here, we show that epigallocatechin gallate (EGCG), one of the most representative catechins present in green tea, acts as a differential inhibitor of human recombinant AKR1B1.	Catechin	83-92	aldo-keto reductase family 1 member B	Homo sapiens	169-175
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Catechin	169-177	BTB domain and CNC homolog 1	Homo sapiens	22-27
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	Catechin	38-47	low density lipoprotein receptor	Homo sapiens	218-222
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	Catechin	38-47	microsomal triglyceride transfer protein	Homo sapiens	224-228
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	Catechin	38-47	apolipoprotein B	Homo sapiens	233-237
33102196-9	2020	Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition.	Catechin	58-69	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like	Malus domestica	94-98
33102196-9	2020	Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition.	Catechin	75-84	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like	Malus domestica	94-98
32492958-7	2020	In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release.	Catechin	117-125	cholecystokinin	Homo sapiens	182-185
32492958-7	2020	In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release.	Catechin	136-144	cholecystokinin	Homo sapiens	182-185
32492958-7	2020	In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release.	Catechin	145-156	cholecystokinin	Homo sapiens	182-185
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Catechin	169-177	kelch like ECH associated protein 1	Homo sapiens	88-93
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Catechin	169-177	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
32344103-4	2020	BACH1 promoted reactive oxygen species (ROS) accumulation while inhibiting cell growth, which could be reversed by the synergistic action of let-7a-5p and miR-25-3p in the co-presence of quercetin and catechin.	Catechin	201-209	BTB domain and CNC homolog 1	Homo sapiens	0-5
32670562-2	2020	The protonated and fragmented behavior of acetone seed extract revealed the presence of gallic acid (MS/MS, m/z 169) and catechin (MSn, m/z 288.3).	Catechin	121-129	moesin	Mus musculus	131-134
31999881-0	2020	Catechins reduce inflammation in lipopolysaccharide-stimulated dental pulp cells by inhibiting activation of the NF-kappaB pathway.	Catechin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	113-122
32106030-3	2020	Hence in this study we aimed to investigate the preventive role of antioxidants present in our diet, like caffeine and catechin hydrate which are commonly found in coffee and tea towards methemoglobin (met-Hb) formation.	Catechin	119-127	hemoglobin subunit gamma 2	Homo sapiens	187-200
32398139-2	2020	This study was to investigate whether the beneficial impact of epigallocatechingallate (EGCG), a type of catechin in green tea on lipids is associated with proprotein convertase subtilisin/kexin type 9 (PCSK9) pathways.	Catechin	71-79	proprotein convertase subtilisin/kexin type 9	Homo sapiens	156-201
32398139-2	2020	This study was to investigate whether the beneficial impact of epigallocatechingallate (EGCG), a type of catechin in green tea on lipids is associated with proprotein convertase subtilisin/kexin type 9 (PCSK9) pathways.	Catechin	71-79	proprotein convertase subtilisin/kexin type 9	Homo sapiens	203-208
32247449-6	2020	Mini rose displayed the highest antioxidant activity in FRAP and DPPH assays before in vitro digestion; its dialyzed and non-dialyzed fraction showed the highest activity in FRAP, correlated to pelargonidin 3,5-diglucoside, catechin, epicatechin galate, epicagocatechin galate, procyanidin A2, quercitin 3-glucoside and trans-resveratrol (r = 0.9).	Catechin	224-232	mechanistic target of rapamycin kinase	Homo sapiens	174-178
31999881-8	2020	CONCLUSIONS: Catechin could reduce lipopolysaccharide-stimulated inflammation in HDPCs by inhibiting activation of the NF-kappaB pathway.	Catechin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	119-128
32326457-0	2020	Comparative Kinetics of Acetyl- and Butyryl-Cholinesterase Inhibition by Green Tea Catechins Relevance to the Symptomatic Treatment of Alzheimer"s Disease.	Catechin	83-92	butyrylcholinesterase	Homo sapiens	36-58
32326457-5	2020	In this study, five natural flavan-3-ol (catechin) compounds: ((-)-epicatechin (EC), catechin, (-)-epicatechin-3-gallate (ECG),) (-)-epigallocatechin (EGC), (-)-epigallocatechin-3-gallate (EGCG), isolated from green tea, were screened for their cholinesterase inhibitory activity using the Ellman assay.	Catechin	41-49	butyrylcholinesterase	Homo sapiens	245-259
32103628-1	2020	SCOPE: Procyanidin C1 (PC1) is an epicatechin trimer found mainly in grapes that is reported to provide several health benefits.	Catechin	34-45	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	23-26
32149508-0	2020	Computational Analysis of the Selective Formation of the C4alpha-C8" Bond in the Intermolecular Coupling of Catechin Derivatives.	Catechin	108-116	complement C4A (Rodgers blood group)	Homo sapiens	57-64
32149508-2	2020	The couplings of catechin derivatives, promoted by Lewis acids, have been widely applied to the syntheses of procyanidin B3 and related flavonoids because the reactions construct the C4alpha-C8" bond in a highly stereo- and regioselective manner.	Catechin	17-25	complement C4A (Rodgers blood group)	Homo sapiens	183-190
32149508-4	2020	Here, we report the results of a computational study to provide plausible origins for the selective C4alpha-C8" bond formation of catechin derivatives 1 and 2 by using models 5 and 7.	Catechin	130-138	complement C4A (Rodgers blood group)	Homo sapiens	100-107
31836515-10	2020	Among the main phenolic compounds of EETg, quercitrin, quercetin and catechin showed the highest binding affinity in silico to MPO.	Catechin	69-77	myeloperoxidase	Homo sapiens	127-130
32246366-0	2020	Effects of Catechin on Activity of Angiotensin-Converting Enzyme and Generation of Reactive Oxygen Species in Rat Aorta.	Catechin	11-19	angiotensin I converting enzyme	Rattus norvegicus	35-64
32218277-0	2020	Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening.	Catechin	10-19	jun proto-oncogene	Mus musculus	28-43
32218277-7	2020	These results suggest that GT-catechin suppresses age-related cognitive decline via increased expression of immediate-early genes that are involved in long-term changes in plasticity of synapses and neuronal circuits.	Catechin	30-38	jun proto-oncogene	Mus musculus	108-123
31756325-3	2020	By in silico docking and molecular modeling we demonstrate favorable binding of different glucuronidated, sulfated or methylated (-)-epicatechin metabolites to different DNA methyltransferases (DNMT1/DNMT3A).	Catechin	118-144	DNA methyltransferase 1	Homo sapiens	194-199
31756325-3	2020	By in silico docking and molecular modeling we demonstrate favorable binding of different glucuronidated, sulfated or methylated (-)-epicatechin metabolites to different DNA methyltransferases (DNMT1/DNMT3A).	Catechin	118-144	DNA methyltransferase 3 alpha	Homo sapiens	200-206
31756325-4	2020	In favour of this model, genomewide DNA methylation profiling of endothelial cells treated with TNF and different (-)-epicatechin metabolites revealed specific DNA methylation changes in gene networks controlling cell adhesion-extravasation endothelial hyperpermeability as well as gamma-aminobutyric acid, renin-angiotensin and nitric oxide hypertension pathways.	Catechin	114-129	renin	Homo sapiens	307-312
31756325-7	2020	In line with biological data, the individual epigenetic response to an (-)-epicatechin diet is associated with different vascular health parameters (glutathione peroxidase 1 and endothelin-1 expression, acetylcholine response), in part involving systemic shifts in blood immune cell types which reduce the neutrophil-lymphocyte ratio (NLR).	Catechin	71-86	glutathione peroxidase 1	Homo sapiens	149-173
31756325-7	2020	In line with biological data, the individual epigenetic response to an (-)-epicatechin diet is associated with different vascular health parameters (glutathione peroxidase 1 and endothelin-1 expression, acetylcholine response), in part involving systemic shifts in blood immune cell types which reduce the neutrophil-lymphocyte ratio (NLR).	Catechin	71-86	endothelin 1	Homo sapiens	178-190
32028059-2	2020	Composition and inhibition analyses suggested that tannic acid (TA), (-)-epicatechin (EC) and phlorizin (PH) were the main active constituents in YAP showing alpha-glucosidase inhibition.	Catechin	69-84	alpha-glucosidase	Malus domestica	158-175
32028059-2	2020	Composition and inhibition analyses suggested that tannic acid (TA), (-)-epicatechin (EC) and phlorizin (PH) were the main active constituents in YAP showing alpha-glucosidase inhibition.	Catechin	86-88	alpha-glucosidase	Malus domestica	158-175
32028059-5	2020	Interestingly, the constants that indicate binding interaction between alpha-glucosidase and TA, PH, EC, including reciprocal of competitive inhibition constant (1/Kic), fluorescence quenching constant (KFQ) and binding energy (Eb), were shown similar orders as TA > PH > EC, contrary to IC50 values.	Catechin	101-103	alpha-glucosidase	Malus domestica	71-88
32246366-5	2020	Catechin increased ACE activity; the maximum increase was achieved in 3 h after administration.	Catechin	0-8	angiotensin I converting enzyme	Rattus norvegicus	19-22
32246366-6	2020	Catechin dose producing a half-maximum increase in ACE activity was 0.04 mug/kg.	Catechin	0-8	angiotensin I converting enzyme	Rattus norvegicus	51-54
32246366-7	2020	The effects of catechin on ACE activity was attenuated by dihydroquercetin and completely abolished by fucoidin.	Catechin	15-23	angiotensin I converting enzyme	Rattus norvegicus	27-30
32521910-0	2020	Anticancer effects of catechin flavonoid in human glioma cells are mediated via autophagy induction, cell cycle arrest, inhibition of cell migration and invasion and targeting MAPK/ERK signalling pathway.	Catechin	22-30	mitogen-activated protein kinase 1	Homo sapiens	181-184
31885091-0	2020	Development and Validation of a Sensitive and Specific LC-MS/MS Cocktail Assay for CYP450 Enzymes; Application to Study the Effect of Catechin on Rat Hepatic CYP Activity.	Catechin	134-142	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-86
32521910-11	2020	The catechin-triggered autophagy was also linked with increase in the expression of LC3II and decrease in p62 expression.	Catechin	4-12	nucleoporin 62	Homo sapiens	106-109
32521910-15	2020	CONCLUSIONS: In conclusion, the results indicate that the naturally occurring catechin showed strong anticancer effects in U87MG human glioma cells by targeting autophagy, cell cycle, cell migration and invasion and targeting MAPK/ERK signalling pathway.	Catechin	78-86	mitogen-activated protein kinase 1	Homo sapiens	231-234
32194324-0	2020	Molecular interaction of tea catechin with bovine beta-lactoglobulin: A spectroscopic and in silico studies.	Catechin	29-37	beta-lactoglobulin	Bos taurus	50-68
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Catechin	82-90	casein beta	Bos taurus	96-108
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Catechin	82-90	beta-lactoglobulin	Bos taurus	116-134
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Catechin	82-90	beta-lactoglobulin	Bos taurus	136-143
32194324-3	2020	We investigated the conformational changes of beta-Lg due to interaction with catechin using spectroscopic and in silico studies.	Catechin	78-86	beta-lactoglobulin	Bos taurus	46-53
32194324-4	2020	Fluorescence quenching data (Stern-Volmer quenching constant) revealed that beta-Lg interacted with catechin via dynamic quenching.	Catechin	100-108	beta-lactoglobulin	Bos taurus	76-83
32194324-5	2020	Thermodynamic data revealed that the interaction between beta-Lg and catechin is endothermic and spontaneously interacted mainly through hydrophobic interactions.	Catechin	69-77	beta-lactoglobulin	Bos taurus	57-64
32194324-6	2020	The UV-Vis absorption and far-UV circular dichroism (CD) spectroscopy exhibited that the tertiary as well as secondary structure of beta-Lg distorted after interaction with catechin.	Catechin	173-181	beta-lactoglobulin	Bos taurus	132-139
32194324-7	2020	Molecular docking and simulation studies also confirm that catechin binds at the central cavity of beta-Lg with high affinity (~105 M-1) and hydrophobic interactions play significant role in the formation of a stable beta-Lg-catechin complex.	Catechin	59-67	beta-lactoglobulin	Bos taurus	99-106
32194324-7	2020	Molecular docking and simulation studies also confirm that catechin binds at the central cavity of beta-Lg with high affinity (~105 M-1) and hydrophobic interactions play significant role in the formation of a stable beta-Lg-catechin complex.	Catechin	59-67	beta-lactoglobulin	Bos taurus	217-224
32194324-7	2020	Molecular docking and simulation studies also confirm that catechin binds at the central cavity of beta-Lg with high affinity (~105 M-1) and hydrophobic interactions play significant role in the formation of a stable beta-Lg-catechin complex.	Catechin	225-233	beta-lactoglobulin	Bos taurus	99-106
32194324-7	2020	Molecular docking and simulation studies also confirm that catechin binds at the central cavity of beta-Lg with high affinity (~105 M-1) and hydrophobic interactions play significant role in the formation of a stable beta-Lg-catechin complex.	Catechin	225-233	beta-lactoglobulin	Bos taurus	217-224
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Catechin	70-78	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
32106523-9	2020	Further, (-)-epicatechin in MDA-MB-231 cells upregulated death receptor (DR4/DR5), increased the ROS production, and modulated pro-apoptotic proteins.	Catechin	9-24	major histocompatibility complex, class II, DR beta 4	Homo sapiens	73-80
32092951-5	2020	We analyzed the in vitro effect of green tea catechins not only for EGCG, but for others residually contained in FontUp , on DYRK1A kinase activity.	Catechin	45-54	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	125-131
31998896-9	2020	Consistently, in L6 myotubes, (-)-epicatechin (EC), a flavonoid abundant in the GPE, prevented palmitate-mediated downregulation of FNDC5/irisin protein expression and secretion, in part via PGC-1alpha activation.	Catechin	30-45	fibronectin type III domain containing 5	Rattus norvegicus	132-137
31998896-9	2020	Consistently, in L6 myotubes, (-)-epicatechin (EC), a flavonoid abundant in the GPE, prevented palmitate-mediated downregulation of FNDC5/irisin protein expression and secretion, in part via PGC-1alpha activation.	Catechin	30-45	PPARG coactivator 1 alpha	Rattus norvegicus	191-201
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Catechin	80-83	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
31955523-0	2020	Catechin relieves hypoxia/reoxygenation-induced myocardial cell apoptosis via down-regulating lncRNA MIAT.	Catechin	0-8	myocardial infarction associated transcript	Rattus norvegicus	101-105
31955523-8	2020	RESULTS: In MI/R rats, catechin improved heart function and down-regulated lncRNA MIAT expression in myocardial tissue.	Catechin	23-31	myocardial infarction associated transcript	Rattus norvegicus	82-86
31955523-9	2020	In H/R-induced H9C2 cells, catechin protected against cell apoptosis, and lncRNA MIAT overexpression attenuated this protective effect of catechin.	Catechin	138-146	myocardial infarction associated transcript	Rattus norvegicus	81-85
31955523-10	2020	We confirmed that transcription factor CREB could bind to MIAT promoter region, and catechin suppressed lncRNA MIAT expression through up-regulating CREB.	Catechin	84-92	myocardial infarction associated transcript	Rattus norvegicus	111-115
31955523-10	2020	We confirmed that transcription factor CREB could bind to MIAT promoter region, and catechin suppressed lncRNA MIAT expression through up-regulating CREB.	Catechin	84-92	cAMP responsive element binding protein 1	Rattus norvegicus	149-153
31955523-11	2020	Catechin improved mitochondrial function and relieved apoptosis through promoting Akt/Gsk-3beta activation.	Catechin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
31955523-11	2020	Catechin improved mitochondrial function and relieved apoptosis through promoting Akt/Gsk-3beta activation.	Catechin	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	86-95
31955523-13	2020	Finally, we found catechin promoted Akt/Gsk-3beta activation through inhibiting MIAT expression in H/R-induced H9C2 cells.	Catechin	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
31955523-13	2020	Finally, we found catechin promoted Akt/Gsk-3beta activation through inhibiting MIAT expression in H/R-induced H9C2 cells.	Catechin	18-26	glycogen synthase kinase 3 alpha	Rattus norvegicus	40-49
31955523-13	2020	Finally, we found catechin promoted Akt/Gsk-3beta activation through inhibiting MIAT expression in H/R-induced H9C2 cells.	Catechin	18-26	myocardial infarction associated transcript	Rattus norvegicus	80-84
31955523-14	2020	CONCLUSION: Catechin relieved H/R-induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk-3beta pathway.	Catechin	12-20	cAMP responsive element binding protein 1	Rattus norvegicus	87-91
31955523-14	2020	CONCLUSION: Catechin relieved H/R-induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk-3beta pathway.	Catechin	12-20	myocardial infarction associated transcript	Rattus norvegicus	99-103
31955523-14	2020	CONCLUSION: Catechin relieved H/R-induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk-3beta pathway.	Catechin	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
31955523-14	2020	CONCLUSION: Catechin relieved H/R-induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk-3beta pathway.	Catechin	12-20	glycogen synthase kinase 3 alpha	Rattus norvegicus	108-117
31816382-3	2020	The results showed that the IC50 of catechin and compounds 2-7 on alpha-glucosidase was lower than that of acarbose.	Catechin	36-44	sucrase-isomaltase	Homo sapiens	66-83
31928660-0	2020	Preferential assimilation of NH4+ over NO3- in tea plant associated with genes involved in nitrogen transportation, utilization and catechins biosynthesis.	Catechin	132-141	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
31991916-0	2020	Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.	Catechin	25-33	sirtuin 1	Rattus norvegicus	97-102
33005588-0	2020	The effect of green tea catechins on breast cancer resistance protein activity and intestinal efflux of aflatoxin B1 via breast cancer resistance protein in Caco-2 cells.	Catechin	24-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	37-69
33005588-2	2020	An efflux of AFB1 was reported to be associated with breast cancer resistance protein (BCRP) whose activity could also be modulated by green tea catechins.	Catechin	145-154	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-85
33005588-2	2020	An efflux of AFB1 was reported to be associated with breast cancer resistance protein (BCRP) whose activity could also be modulated by green tea catechins.	Catechin	145-154	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-91
33005588-3	2020	The purpose of this study was, therefore, to examine the impacts of green tea catechins on BCRP activity in Caco-2 cells by H33342 (bis-benzamide, BCRP substrate) accumulation and AFB1 efflux.	Catechin	78-87	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	91-95
33005588-3	2020	The purpose of this study was, therefore, to examine the impacts of green tea catechins on BCRP activity in Caco-2 cells by H33342 (bis-benzamide, BCRP substrate) accumulation and AFB1 efflux.	Catechin	78-87	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	147-151
33005588-5	2020	Pre-incubation with green tea and gallate catechins (ECG and EGCG) significantly reduced the efflux ratio of AFB1 (p < 0.05) and significantly increased the intracellular H33342 substrate (p < 0.05) in Caco-2 cells, clearly indicating the inhibitory effects of green tea and gallate catechins on BCRP function.	Catechin	42-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	296-300
33005588-8	2020	The findings from this study concluded the roles of BCRP as an efflux transporter for AFB1 and could be modulated by the exposure of green tea catechins.	Catechin	143-152	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	52-56
33005588-9	2020	Owing to a reduction of its efflux, an inhibitory effect of BCRP when pre-exposed with green tea catechins could be crucial for AFB1 cellular accumulation.	Catechin	97-106	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	60-64
31952253-8	2020	ACE inhibitory effect determined by HPLC was higher than 78%, being correlated with catechin and p-coumaric acid.	Catechin	84-92	angiotensin-converting enzyme	Apis mellifera	0-3
31808777-6	2020	(-)-Epicatechin administration restored kidney function parameters, oxidative stress markers, expression of p47phox, gp91phox, and NOX4 and NOS activity to control values.	Catechin	0-15	neutrophil cytosolic factor 1	Rattus norvegicus	108-115
31808777-6	2020	(-)-Epicatechin administration restored kidney function parameters, oxidative stress markers, expression of p47phox, gp91phox, and NOX4 and NOS activity to control values.	Catechin	0-15	cytochrome b-245 beta chain	Rattus norvegicus	117-125
31808777-6	2020	(-)-Epicatechin administration restored kidney function parameters, oxidative stress markers, expression of p47phox, gp91phox, and NOX4 and NOS activity to control values.	Catechin	0-15	NADPH oxidase 4	Rattus norvegicus	131-135
31985369-9	2020	Hence, in vitro COX-2 inhibitory assay performed for epicatechin, daidzein and compared with known analgesic agent diclofenac revealed a pronounced dose dependent inhibitory activity.	Catechin	53-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
31929529-6	2020	A total of thirteen compounds were identified in HECA, mainly quercetin, kaempferol and glucoside derivatives of both, besides catechin and epicatechin known as wound healing agents.	Catechin	127-135	hdc homolog, cell cycle regulator	Mus musculus	49-53
31929529-6	2020	A total of thirteen compounds were identified in HECA, mainly quercetin, kaempferol and glucoside derivatives of both, besides catechin and epicatechin known as wound healing agents.	Catechin	140-151	hdc homolog, cell cycle regulator	Mus musculus	49-53
32682376-6	2020	RESULTS: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine.	Catechin	41-50	solute carrier family 22 member 12	Homo sapiens	201-206
32682376-6	2020	RESULTS: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine.	Catechin	41-50	potassium two pore domain channel subfamily K member 3	Homo sapiens	208-212
32682376-6	2020	RESULTS: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine.	Catechin	41-50	solute carrier family 22 member 8	Homo sapiens	214-218
32682376-6	2020	RESULTS: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine.	Catechin	41-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	220-225
32682376-6	2020	RESULTS: This review details the role of catechins in inhibiting the activity of xanthine oxidase to decrease uric acid overproduction in liver and in regulating expressions of uric acid transporters, URAT1, OAT1, OAT3, ABCG2 and GLUT9, to balance levels of uric acid secretion and reabsorption through the kidney and intestine.	Catechin	41-50	solute carrier family 2 member 9	Homo sapiens	230-235
31529081-2	2019	We demonstrated that the agonism of the delta opioid receptor (DOR) by epicatechin preserves the tight junction proteins in ARPE-19 cells under diabetic conditions.	Catechin	71-82	opioid receptor, delta 1	Mus musculus	63-66
31677553-0	2020	(-)-Epicatechin and NADPH oxidase inhibitors prevent bile acid-induced Caco-2 monolayer permeabilization through ERK1/2 modulation.	Catechin	0-15	mitogen-activated protein kinase 3	Homo sapiens	113-119
31677553-7	2020	Prevention of DCA-induced ERK1/2 activation with EC, VAS-2870, apocynin and the MEK inhibitor U0126, also prevented monolayer permeabilization, stressing the key involvement of ERK1/2 in this process and its redox regulation.	Catechin	49-51	mitogen-activated protein kinase 3	Homo sapiens	26-32
31393601-11	2019	Green tea extract (GTE) rich in catechins also inhibited plasmin activity in the milk.	Catechin	32-41	plasminogen	Homo sapiens	57-64
31799477-2	2020	Our recent works in obese rodent models demonstrate that catechin-rich green tea extract (GTE) improves gut barrier integrity to alleviate the translocation of gut-derived endotoxin and its consequent pro-inflammatory responses mediated through Toll-like receptor-4/nuclear factor kappaB (TLR4/NFkappaB) signaling.	Catechin	57-65	toll like receptor 4	Homo sapiens	289-293
31799477-2	2020	Our recent works in obese rodent models demonstrate that catechin-rich green tea extract (GTE) improves gut barrier integrity to alleviate the translocation of gut-derived endotoxin and its consequent pro-inflammatory responses mediated through Toll-like receptor-4/nuclear factor kappaB (TLR4/NFkappaB) signaling.	Catechin	57-65	nuclear factor kappa B subunit 1	Homo sapiens	294-302
31621731-4	2019	Epicatechin effect on primary hemostasis, coagulation and fibrinolysis was assessed by measuring platelet aggregation using light transmission aggregometry, thrombin generation and clot lysis time (CLT), respectively.	Catechin	0-11	coagulation factor II, thrombin	Homo sapiens	157-165
31621731-6	2019	The endogenous thrombin potential was significantly reduced starting from 1 muM epicatechin (1332 +- 230 versus 1548 +- 241 nM min for control) (p < 0.01).	Catechin	80-91	coagulation factor II, thrombin	Homo sapiens	15-23
31649709-7	2019	For the flavol-3-ols sub-group, epicatechin rather than catechin was elevated in MYB10 lines compared with the control fruit.	Catechin	32-43	transcription factor MYB113-like	Malus domestica	81-86
31649709-7	2019	For the flavol-3-ols sub-group, epicatechin rather than catechin was elevated in MYB10 lines compared with the control fruit.	Catechin	35-43	transcription factor MYB113-like	Malus domestica	81-86
31577096-0	2019	Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP.	Catechin	10-19	microtubule associated protein 9	Homo sapiens	108-112
31816197-5	2020	We have previously shown that galloylated catechins are able to prevent LtxA delivery to host cells by altering the toxin"s secondary structure and preventing binding to cholesterol on the host cell membrane.	Catechin	42-51	RTX family leukotoxin LtxA	Aggregatibacter actinomycetemcomitans	72-76
31574193-1	2019	SCOPE: Catechin-rich green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) by lowering endotoxin-TLR4 (Toll-like receptor-4)-NFkappaB (nuclear factor kappa-B) inflammation.	Catechin	7-15	toll-like receptor 4	Mus musculus	114-118
31574193-1	2019	SCOPE: Catechin-rich green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) by lowering endotoxin-TLR4 (Toll-like receptor-4)-NFkappaB (nuclear factor kappa-B) inflammation.	Catechin	7-15	toll-like receptor 4	Mus musculus	120-140
31574193-1	2019	SCOPE: Catechin-rich green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) by lowering endotoxin-TLR4 (Toll-like receptor-4)-NFkappaB (nuclear factor kappa-B) inflammation.	Catechin	7-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-150
31574193-10	2019	CONCLUSION: The defined anti-inflammatory/metabolic interactions advance an understanding of the mechanism by which GTE catechins protect against NFkappaB-mediated liver injury in NASH.	Catechin	120-129	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-154
31614668-1	2019	Flavan-3-ols (FLs), specifically catechin and its oligomer B-type procyanidins, are suggested to potently bind to bovine serum albumin (BSA).	Catechin	33-41	albumin	Bos taurus	121-134
31529081-7	2019	The silencing of DOR in retina of diabetic mice partially abolished the protective effects of epicatechin.	Catechin	94-105	opioid receptor, delta 1	Mus musculus	17-20
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	tumor necrosis factor	Homo sapiens	169-196
31252129-0	2019	Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-kappaB, AP-1, and MAPKs signaling pathways.	Catechin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	109-118
31252129-0	2019	Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-kappaB, AP-1, and MAPKs signaling pathways.	Catechin	31-39	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-124
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	tumor necrosis factor	Homo sapiens	198-207
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	C-reactive protein	Homo sapiens	210-228
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	C-reactive protein	Homo sapiens	230-233
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	interleukin 6	Homo sapiens	240-253
31309655-1	2019	Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6).	Catechin	0-8	interleukin 6	Homo sapiens	255-259
31311265-9	2019	After the optimization process, the best sensitivity was obtained for gallic acid, quercetin, catechin, kaempferol, and caffeic acid with detection limits of 0.98, 1.36, 1.48, 1.81, and 2.55 ng mL-1, respectively.	Catechin	94-102	2'-5' oligoadenylate synthetase 1B	Mus musculus	194-198
31353905-2	2019	However, epigallocatechin gallate (EGCG), which is the most predominant catechin in green tea, has opposite effects on the function of OATP1B1 and OATP1B3.	Catechin	17-25	solute carrier organic anion transporter family member 1B1	Homo sapiens	135-142
31353905-2	2019	However, epigallocatechin gallate (EGCG), which is the most predominant catechin in green tea, has opposite effects on the function of OATP1B1 and OATP1B3.	Catechin	17-25	solute carrier organic anion transporter family member 1B3	Homo sapiens	147-154
31334505-3	2019	Further study proved that catechin could not only significantly suppress the increase of blood glucose levels, but also inhibit alpha-amylase, alpha-glucosidase and beta-glucosidase strongly with IC50 values of 0.533 mg mL-1, 0.307 mg mL-1 and 0.413 mg mL-1, respectively.	Catechin	26-34	L1 cell adhesion molecule	Mus musculus	235-239
31334505-3	2019	Further study proved that catechin could not only significantly suppress the increase of blood glucose levels, but also inhibit alpha-amylase, alpha-glucosidase and beta-glucosidase strongly with IC50 values of 0.533 mg mL-1, 0.307 mg mL-1 and 0.413 mg mL-1, respectively.	Catechin	26-34	sucrase-isomaltase	Homo sapiens	143-160
31334505-3	2019	Further study proved that catechin could not only significantly suppress the increase of blood glucose levels, but also inhibit alpha-amylase, alpha-glucosidase and beta-glucosidase strongly with IC50 values of 0.533 mg mL-1, 0.307 mg mL-1 and 0.413 mg mL-1, respectively.	Catechin	26-34	L1 cell adhesion molecule	Mus musculus	220-224
31092697-6	2019	Recombinant VvLAR1 and VvLAR2 convert Cys-C and Cys-EC into (+)-catechin and (-)-epicatechin, respectively, in vitro.	Catechin	64-72	leucoanthocyanidin reductase 1	Vitis vinifera	12-18
31334505-3	2019	Further study proved that catechin could not only significantly suppress the increase of blood glucose levels, but also inhibit alpha-amylase, alpha-glucosidase and beta-glucosidase strongly with IC50 values of 0.533 mg mL-1, 0.307 mg mL-1 and 0.413 mg mL-1, respectively.	Catechin	26-34	L1 cell adhesion molecule	Mus musculus	235-239
31313292-10	2019	Natural products, such as catechin and resveratrol, can substitute chemical synthesis antioxidants, such as butylated hydroxylanisole and tert-butylhydroquinone, in food processing, which inhibit the formation of glycated lipids.	Catechin	26-34	telomerase reverse transcriptase	Homo sapiens	138-142
30357845-0	2019	AtHB2, a class II HD-ZIP protein, negatively regulates the expression of CsANS, which encodes a key enzyme in Camellia sinensis catechin biosynthesis.	Catechin	128-136	homeobox protein 2	Arabidopsis thaliana	0-5
30357845-3	2019	Among the enzymes involved in catechin biosynthesis, ANTHOCYANIDIN SYNTHASE (CsANS) functions at a branch point and play a critical role.	Catechin	30-38	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	53-75
31358798-10	2019	In conclusion, this study identified DTDST as a novel intestinal EGCg transporter that is upregulated after repeated oral catechin intake.	Catechin	122-130	solute carrier family 26 member 2 S homeolog	Xenopus laevis	37-42
31353737-3	2019	After 4 weeks" treatment, the extract (standardized to epicatechin and scopoletin), arrested Jurkat cell-cycle at the G0/G1 phase and activated the caspase-3 and caspase-8 (death-receptor extrinsic pathways).	Catechin	55-66	caspase 8	Homo sapiens	162-171
31234659-9	2019	Interestingly, EC can enhance the activity of intestine stem cells labelled by Lgr5 and promote intestinal epithelium regeneration determined by HE and immunofluorescence staining in vivo and in vitro.	Catechin	15-17	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	79-83
31234659-10	2019	We also found that EC can activate the Wnt/beta-catenin signal pathway confirmed by TCF/LEF luciferase reporter assay.	Catechin	19-21	catenin (cadherin associated protein), beta 1	Mus musculus	43-55
31234659-11	2019	Together, EC can provide the protective effect on intestine and promote intestinal regeneration after radiation through Nrf2 and Wnt/beta-catenin signal pathway.	Catechin	10-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
31234659-11	2019	Together, EC can provide the protective effect on intestine and promote intestinal regeneration after radiation through Nrf2 and Wnt/beta-catenin signal pathway.	Catechin	10-12	catenin (cadherin associated protein), beta 1	Mus musculus	133-145
31379411-0	2019	Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (-)-epicatechin tetramer.	Catechin	152-167	corticotropin releasing hormone	Mus musculus	0-31
31092697-6	2019	Recombinant VvLAR1 and VvLAR2 convert Cys-C and Cys-EC into (+)-catechin and (-)-epicatechin, respectively, in vitro.	Catechin	64-72	leucoanthocyanidin reductase 2	Vitis vinifera	23-29
31092697-6	2019	Recombinant VvLAR1 and VvLAR2 convert Cys-C and Cys-EC into (+)-catechin and (-)-epicatechin, respectively, in vitro.	Catechin	77-92	leucoanthocyanidin reductase 1	Vitis vinifera	12-18
31092697-6	2019	Recombinant VvLAR1 and VvLAR2 convert Cys-C and Cys-EC into (+)-catechin and (-)-epicatechin, respectively, in vitro.	Catechin	77-92	leucoanthocyanidin reductase 2	Vitis vinifera	23-29
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	140-151	leucoanthocyanidin reductase 1	Vitis vinifera	0-6
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	140-151	leucoanthocyanidin reductase 2	Vitis vinifera	10-16
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	143-151	leucoanthocyanidin reductase 1	Vitis vinifera	0-6
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	143-151	leucoanthocyanidin reductase 2	Vitis vinifera	10-16
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	356-367	leucoanthocyanidin reductase 1	Vitis vinifera	0-6
31092697-9	2019	VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.	Catechin	356-367	leucoanthocyanidin reductase 2	Vitis vinifera	10-16
31237890-9	2019	The expression level of both genes increased in the presence of (+)-catechin and, in the case of PSPTO_0820, also in response to trans-cinnamic acid.	Catechin	64-76	efflux RND transporter permease subunit	Pseudomonas syringae pv. tomato str. DC3000	97-107
31100089-0	2019	Catechin attenuates TNF-alpha induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes.	Catechin	0-8	sirtuin 1	Homo sapiens	69-74
30722900-3	2019	It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid &gt; chlorogenic acid &gt; caffeic acid &gt; epicatechin.	Catechin	77-88	probable alpha-amylase 2	Malus domestica	94-107
30722900-3	2019	It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid &gt; chlorogenic acid &gt; caffeic acid &gt; epicatechin.	Catechin	234-245	probable alpha-amylase 2	Malus domestica	94-107
31212946-8	2019	A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites.	Catechin	177-186	mitogen-activated protein kinase 1	Homo sapiens	36-39
31212946-8	2019	A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites.	Catechin	177-186	cAMP responsive element binding protein 1	Homo sapiens	40-44
31212946-8	2019	A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites.	Catechin	177-186	brain derived neurotrophic factor	Homo sapiens	45-49
31212946-8	2019	A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites.	Catechin	177-186	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	110-113
31212946-8	2019	A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites.	Catechin	177-186	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	124-127
31263675-4	2019	Therefore, the current study was aimed to improve the anticancer activity of Se-HAp nanoparticles through catechins (CC) modification owing to their high cancer therapeutic value.	Catechin	106-115	reticulon 3	Homo sapiens	80-83
31263675-5	2019	The sequentially developed catechins modified Se-HAp nanocomposites (CC/Se-HAp) were characterized for various physico-chemical properties and antitumor activity.	Catechin	27-36	reticulon 3	Homo sapiens	49-52
31263675-6	2019	Structural analysis showed the synthesis of small rod-like single phase HAp nanoparticles (60 +- 15 nm), which effectively interacted with Se and catechins and formed agglomerated structures.	Catechin	146-155	reticulon 3	Homo sapiens	72-75
31263675-8	2019	Cell toxicity analysis showed that catechins modification improved the antitumor activity of Se-HAp nanocomposites by inducing apoptosis of human osteosarcoma MNNG/HOS cell lines, through generation of reactive oxygen species (ROS) which in turn activated the caspase-3 pathway, without significantly affecting the growth of human normal bone marrow stem cells (hBMSCs).	Catechin	35-44	reticulon 3	Homo sapiens	96-99
31263675-8	2019	Cell toxicity analysis showed that catechins modification improved the antitumor activity of Se-HAp nanocomposites by inducing apoptosis of human osteosarcoma MNNG/HOS cell lines, through generation of reactive oxygen species (ROS) which in turn activated the caspase-3 pathway, without significantly affecting the growth of human normal bone marrow stem cells (hBMSCs).	Catechin	35-44	caspase 3	Homo sapiens	260-269
30840834-6	2019	Preradiation and postradiation treatments with EC mitigate ROS-mediated mitochondrial damage, IR-induced oxidative stress responses including reduction of superoxide dismutase activity, and elevated nuclear factor erythroid 2-related factor 2 expression, and they improve human fibroblast survival.	Catechin	47-49	NFE2 like bZIP transcription factor 2	Homo sapiens	199-242
31100089-0	2019	Catechin attenuates TNF-alpha induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes.	Catechin	0-8	tumor necrosis factor	Homo sapiens	20-29
31100089-0	2019	Catechin attenuates TNF-alpha induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes.	Catechin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	64-68
31100089-3	2019	However, the mechanism of catechin to prevent inflammation in 3T3-L1 adipocytes caused by TNF-alpha remains unknown.	Catechin	26-34	tumor necrosis factor	Homo sapiens	90-99
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 1 alpha	Homo sapiens	79-88
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 1 alpha	Homo sapiens	90-98
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 6	Homo sapiens	100-104
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	inositol-3-phosphate synthase 1	Homo sapiens	151-155
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 4	Homo sapiens	241-245
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 10	Homo sapiens	250-255
31100089-10	2019	Catechin also inhibited the activation of NF-kappaB, AMPK, FOXO3a and SIRT1, but increased the phosphorylation level of the above factors.	Catechin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	42-51
31100089-10	2019	Catechin also inhibited the activation of NF-kappaB, AMPK, FOXO3a and SIRT1, but increased the phosphorylation level of the above factors.	Catechin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-57
30642482-0	2019	In vitro gastrointestinal digest of catechin-modified beta-conglycinin oxidized by lipoxygenase-catalyzed linoleic acid peroxidation.	Catechin	36-44	linoleate 9S-lipoxygenase-4	Glycine max	83-95
31100089-10	2019	Catechin also inhibited the activation of NF-kappaB, AMPK, FOXO3a and SIRT1, but increased the phosphorylation level of the above factors.	Catechin	0-8	forkhead box O3	Homo sapiens	59-65
30642482-3	2019	The interaction of UH-7S/H-7S with catechin dramatically inhibited LOX-catalyzed LA peroxidation-induced protein oxidation.	Catechin	35-43	linoleate 9S-lipoxygenase-4	Glycine max	67-70
31100089-10	2019	Catechin also inhibited the activation of NF-kappaB, AMPK, FOXO3a and SIRT1, but increased the phosphorylation level of the above factors.	Catechin	0-8	sirtuin 1	Homo sapiens	70-75
31100089-11	2019	All these results indicated that as a potential therapeutic strategy catechin has the ability of attenuating inflammatory response triggered by TNF-alpha through signaling cascades involved in inflammation and cytokines.	Catechin	69-77	tumor necrosis factor	Homo sapiens	144-153
30424599-5	2019	Furthermore, catechins ameliorated liver fibrosis, as evidenced by the reduced expression of desmin, alpha-smooth muscle actin, transforming growth factor beta (TGF-beta), and downstream ERK1/2 and Smad1/2 phosphorylation.	Catechin	13-22	actin gamma 2, smooth muscle	Rattus norvegicus	101-126
30424599-5	2019	Furthermore, catechins ameliorated liver fibrosis, as evidenced by the reduced expression of desmin, alpha-smooth muscle actin, transforming growth factor beta (TGF-beta), and downstream ERK1/2 and Smad1/2 phosphorylation.	Catechin	13-22	transforming growth factor, beta 1	Rattus norvegicus	161-169
30424599-0	2019	Green Tea Catechins Effectively Altered Hepatic Fibrogenesis in Rats by Inhibiting ERK and Smad1/2 Phosphorylation.	Catechin	10-19	Eph receptor B1	Rattus norvegicus	83-86
30424599-0	2019	Green Tea Catechins Effectively Altered Hepatic Fibrogenesis in Rats by Inhibiting ERK and Smad1/2 Phosphorylation.	Catechin	10-19	SMAD family member 1	Rattus norvegicus	91-98
30424599-5	2019	Furthermore, catechins ameliorated liver fibrosis, as evidenced by the reduced expression of desmin, alpha-smooth muscle actin, transforming growth factor beta (TGF-beta), and downstream ERK1/2 and Smad1/2 phosphorylation.	Catechin	13-22	mitogen activated protein kinase 3	Rattus norvegicus	187-193
30424599-5	2019	Furthermore, catechins ameliorated liver fibrosis, as evidenced by the reduced expression of desmin, alpha-smooth muscle actin, transforming growth factor beta (TGF-beta), and downstream ERK1/2 and Smad1/2 phosphorylation.	Catechin	13-22	desmin	Rattus norvegicus	93-99
30983343-7	2019	Moreover, the expression of multi-drug resistance protein 2 (MRP2) after 3 h of incubation with either 50 muM EGCG or 50 muM EC was elevated by 1.58- and 2.98-fold, respectively, while 50 muM ECG had no significantly effects.	Catechin	125-127	ATP binding cassette subfamily C member 2	Homo sapiens	28-59
30424599-5	2019	Furthermore, catechins ameliorated liver fibrosis, as evidenced by the reduced expression of desmin, alpha-smooth muscle actin, transforming growth factor beta (TGF-beta), and downstream ERK1/2 and Smad1/2 phosphorylation.	Catechin	13-22	SMAD family member 1	Rattus norvegicus	198-205
30983343-7	2019	Moreover, the expression of multi-drug resistance protein 2 (MRP2) after 3 h of incubation with either 50 muM EGCG or 50 muM EC was elevated by 1.58- and 2.98-fold, respectively, while 50 muM ECG had no significantly effects.	Catechin	125-127	ATP binding cassette subfamily C member 2	Homo sapiens	61-65
30983343-8	2019	In addition, the expression of P-glycoprotein (P-gp) after treatment with either 50 muM EGCG, 50 muM ECG, or 50 muM EC was enhanced by 1.53-, 1.63-, and 1.80-fold, respectively.	Catechin	101-103	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
30983343-8	2019	In addition, the expression of P-glycoprotein (P-gp) after treatment with either 50 muM EGCG, 50 muM ECG, or 50 muM EC was enhanced by 1.53-, 1.63-, and 1.80-fold, respectively.	Catechin	101-103	ATP binding cassette subfamily B member 1	Homo sapiens	47-51
30424599-7	2019	In addition, catechins conferred their protective role by downregulating the proinflammation cytokines TGF-beta, tumor necrosis factor alpha, and interleukin 17.	Catechin	13-22	transforming growth factor, beta 1	Rattus norvegicus	103-111
30424599-7	2019	In addition, catechins conferred their protective role by downregulating the proinflammation cytokines TGF-beta, tumor necrosis factor alpha, and interleukin 17.	Catechin	13-22	tumor necrosis factor	Rattus norvegicus	113-140
31092862-4	2019	During the molecular modelling studies of some naturally occurring flavonoids such as quercetin, luteolin, myricetin, kaempferol, naringin, hesperidin, galangin, baicalein and epicatechin with human ERalpha (3ERT and 1GWR), we observed that most of the ligands bound to the active site pocket of both 3ERT and 1GWR.	Catechin	176-187	estrogen receptor 1	Homo sapiens	199-206
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Catechin	4-12	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	171-177
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Catechin	4-12	sterol regulatory element binding transcription factor 2	Homo sapiens	178-184
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Catechin	4-12	low density lipoprotein receptor	Homo sapiens	185-189
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Catechin	4-12	hepatocyte nuclear factor 4 alpha	Homo sapiens	199-208
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Catechin	4-12	apolipoprotein B	Homo sapiens	213-217
31007758-2	2019	The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro.	Catechin	73-85	tumor necrosis factor	Mus musculus	173-182
31007758-2	2019	The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro.	Catechin	73-85	interleukin 6	Mus musculus	184-188
31007758-2	2019	The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro.	Catechin	73-85	interleukin 1 beta	Mus musculus	193-201
31061619-1	2019	The aim of this study is to discuss the non-catechin flavonoids (NCF) from Camellia sinensis (L.) O. Kuntze seed improving TNF-alpha impaired insulin stimulated glucose uptake and insulin signaling.	Catechin	44-52	tumor necrosis factor	Homo sapiens	123-132
30856467-2	2019	We hypothesized that catechin-rich green tea extract (GTE) would protect against obesity-associated TLR4/NFkappaB inflammation by alleviating gut dysbiosis and limiting endotoxin translocation.	Catechin	21-29	toll-like receptor 4	Mus musculus	100-104
30856467-2	2019	We hypothesized that catechin-rich green tea extract (GTE) would protect against obesity-associated TLR4/NFkappaB inflammation by alleviating gut dysbiosis and limiting endotoxin translocation.	Catechin	21-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-113
30863991-4	2019	The flavanol epicatechin (EPI) inhibits p75NTR-mediated signaling and apoptosis by pro-NGF.	Catechin	26-29	nerve growth factor receptor	Rattus norvegicus	40-46
30863991-4	2019	The flavanol epicatechin (EPI) inhibits p75NTR-mediated signaling and apoptosis by pro-NGF.	Catechin	26-29	nerve growth factor	Rattus norvegicus	87-90
30851383-0	2019	Structural and energetic basis for novel epicatechin derivatives acting as GPER agonists through the MMGBSA method.	Catechin	41-52	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	0-15	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	0-15	nitric oxide synthase 3	Homo sapiens	164-168
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	4-7	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	4-7	nitric oxide synthase 3	Homo sapiens	164-168
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-4	2019	In this contribution, we explore the structural and energetic changes coupling the binding of Epi and its four derivatives to GPER.	Catechin	94-97	G protein-coupled estrogen receptor 1	Homo sapiens	126-130
30851383-7	2019	Structural analysis demonstrated that Epi, Epi-4-prop and Epi-5-prop share more similar interactions at GPER binding sites with similar conformational behavior than with Epi-prop and Epi-Ms.	Catechin	38-41	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
30822691-10	2019	Taken together, this study demonstrates that EPI attenuates MCT-induced HSOS by reducing liver oxidative injury via activating Nrf2 antioxidant pathway and inhibiting liver inflammatory injury through abrogating NFkappaB signaling pathway initiated by HSP60.	Catechin	45-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
30229432-4	2019	Furthermore, the reported agonists for the expression of DGKtheta, cAMP and GW4064, the known inhibitor for DGKtheta enzyme activity, R59949, and a potential regulator for DGKtheta enzyme expression, EGCG (the major catechin in green tea), were applied to the reporter cell line.	Catechin	216-224	diacylglycerol kinase theta	Homo sapiens	57-65
30807184-7	2019	Transcription factor Sp1 was involved in hERG protein downregulation induced by rosuvastatin, and the result was verified by Sp1 siRNA and Sp1 agonist epicatechin.	Catechin	151-162	ETS transcription factor ERG	Homo sapiens	41-45
30822691-10	2019	Taken together, this study demonstrates that EPI attenuates MCT-induced HSOS by reducing liver oxidative injury via activating Nrf2 antioxidant pathway and inhibiting liver inflammatory injury through abrogating NFkappaB signaling pathway initiated by HSP60.	Catechin	45-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	212-220
30822691-10	2019	Taken together, this study demonstrates that EPI attenuates MCT-induced HSOS by reducing liver oxidative injury via activating Nrf2 antioxidant pathway and inhibiting liver inflammatory injury through abrogating NFkappaB signaling pathway initiated by HSP60.	Catechin	45-48	heat shock protein 1 (chaperonin)	Mus musculus	252-257
30832407-7	2019	In further investigations of the mechanisms involved, resveratrol, catechin, and berberine increased SIRT1 enzyme activity and p-AMPKalphaThr172 protein, which are involved in mitochondrial biogenesis.	Catechin	67-75	sirtuin 1	Homo sapiens	101-106
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Catechin	55-63	toll-like receptor 4	Mus musculus	93-97
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Catechin	321-329	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-127
30701979-0	2019	A Computational Study on the Stereo- and Regioselective Formation of the C4alpha-C6" Bond of Tethered Catechin Moieties by an Exhaustive Search of the Transition States.	Catechin	102-110	complement C4A (Rodgers blood group)	Homo sapiens	73-80
30701979-10	2019	The present study supports preferential C4alpha-C6" bond formation of the tethered catechins.	Catechin	83-92	complement C4A (Rodgers blood group)	Homo sapiens	40-47
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Catechin	321-329	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Catechin	321-329	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Catechin	43-51	toll-like receptor 4	Mus musculus	116-136
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Catechin	55-63	myeloid differentiation primary response gene 88	Mus musculus	98-103
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Catechin	55-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Catechin	61-69	tumor necrosis factor	Mus musculus	180-207
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Catechin	43-51	interleukin-1 receptor-associated kinase 1	Mus musculus	219-224
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Catechin	61-69	interleukin 1 beta	Mus musculus	209-226
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Catechin	43-51	TNF receptor-associated factor 6	Mus musculus	226-231
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Catechin	61-69	prostaglandin-endoperoxide synthase 2	Mus musculus	255-271
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Catechin	43-51	mitogen-activated protein kinase kinase kinase 7	Mus musculus	237-241
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Catechin	41-49	toll-like receptor 4	Mus musculus	171-175
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Catechin	41-49	myeloid differentiation primary response gene 88	Mus musculus	176-181
30195042-0	2019	Antioxidant and pro-oxidant mechanisms of (+) catechin in microsomal CYP2E1-dependent oxidative stress.	Catechin	46-54	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	69-75
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Catechin	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	191-200
30195042-1	2019	The objectives of this work were to evaluate the effects of catechin on cytochrome P450 2E1 (CYP2E1)-dependent oxidative stress.	Catechin	60-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	72-91
30195042-1	2019	The objectives of this work were to evaluate the effects of catechin on cytochrome P450 2E1 (CYP2E1)-dependent oxidative stress.	Catechin	60-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	93-99
30195042-10	2019	In conclusion, catechin exhibits both antioxidant (superoxide-scavenging) and pro-oxidant effects under CYP2E1-dependent oxidative stress.	Catechin	15-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	104-110
30172871-2	2019	The binding capacity of hesperetin (HES), luteolin (LUT), quercetin (QUE), catechin (CAT) and rutin (RUT) with pancreatic alpha-amylase were evaluated, using UV-Vis spectroscopy, fluorescence and molecular docking.	Catechin	75-83	amylase alpha 2A	Homo sapiens	111-135
30604799-2	2019	Administration of (-)-epicatechin to high-fructose-fed rats prevented NF-kappaB activation and up-regulation of the NADPH oxidase 4 (NOX4) in the kidney cortex.	Catechin	18-33	NADPH oxidase 4	Rattus norvegicus	116-131
30604799-2	2019	Administration of (-)-epicatechin to high-fructose-fed rats prevented NF-kappaB activation and up-regulation of the NADPH oxidase 4 (NOX4) in the kidney cortex.	Catechin	18-33	NADPH oxidase 4	Rattus norvegicus	133-137
30626086-6	2019	Treatment with major polyphenols of PN3, including catechin, chlorogenic acid, caffeic acid, and p-coumaric acid, also improved AA + iron-mediated oxidative stress and, thus, improved cell viability.	Catechin	51-59	sodium voltage-gated channel alpha subunit 10	Homo sapiens	36-39
30589259-2	2019	Copigmentation is a well-known color change phenomenon resulting from the complexation of flavonoids that deepens and strengthens the color of the solution, whereas MGR/catechin complexation results in the opposite change in color (i.e., weakening).	Catechin	169-177	MGR6	Homo sapiens	165-168
30646591-2	2019	In this study, we evaluated the effects of two fractions (F4 and F6) from Swietenia macrophylla and purified catechin on the muscle damage caused by a myotoxic PLA2 from Colombian Bothrops asper venom (BaColPLA2) in mice and by Bothrops marmoratus venom from Brazil in mouse phrenic nerve-diaphragm muscle (PND) preparations in vitro.	Catechin	109-117	phospholipase A2, group V	Mus musculus	160-164
30646591-10	2019	These findings indicate that fractions and catechin from S. macrophylla can reduce the muscle damage caused by Bothrops venom and PLA2.	Catechin	43-51	phospholipase A2, group V	Mus musculus	130-134
31258092-7	2019	RESULTS: Among the natural compounds morin (IC50 = 1.32 microM), chlorogenic acid (IC50 = 6.17 microM), (+)-catechin (IC50 = 0.86 microM), alizarin (IC50 = 0.88 microM), fisetin (IC50 = 5.78 microM) and rutin (IC50 = 25.3 microM) exhibited COMT inhibition.	Catechin	108-116	catechol-O-methyltransferase	Homo sapiens	240-244
30447350-1	2019	Emerging evidence supports a beneficial action of the flavan-3-ol (-)-epicatechin (EC) on insulin sensitivity and potential impact on the development/progression of type 2 diabetes (T2D).	Catechin	66-81	insulin	Homo sapiens	90-97
31613724-8	2019	Additionally, epigallocatechin as well as epicatechin and epigallocatechin gallates were observed to be inhibited on both SGLT1 and GLUT2.	Catechin	42-53	solute carrier family 5 member 1	Homo sapiens	122-127
31613724-8	2019	Additionally, epigallocatechin as well as epicatechin and epigallocatechin gallates were observed to be inhibited on both SGLT1 and GLUT2.	Catechin	42-53	solute carrier family 2 member 2	Homo sapiens	132-137
29468975-6	2019	Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-kappaB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways.	Catechin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	90-99
29468975-6	2019	Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-kappaB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways.	Catechin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	108-151
29468975-6	2019	Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-kappaB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways.	Catechin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
29468975-7	2019	CONCLUSION: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.	Catechin	53-62	NFE2 like bZIP transcription factor 2	Homo sapiens	222-226
30447350-1	2019	Emerging evidence supports a beneficial action of the flavan-3-ol (-)-epicatechin (EC) on insulin sensitivity and potential impact on the development/progression of type 2 diabetes (T2D).	Catechin	83-85	insulin	Homo sapiens	90-97
30447350-2	2019	In humans, supplementation with EC-rich foods, extracts, and pure EC improves insulin sensitivity and glucose tolerance in normal weight, overweight, obese and T2D individuals.	Catechin	32-34	insulin	Homo sapiens	78-85
30596805-0	2018	Retraction: Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition.	Catechin	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
30453148-0	2019	Epicatechin alleviates inflammation in lipopolysaccharide-induced acute lung injury in mice by inhibiting the p38 MAPK signaling pathway.	Catechin	0-11	mitogen-activated protein kinase 14	Mus musculus	110-113
30453148-11	2019	In vitro kinase assays confirmed the ability of EC to directly inhibit purified p38 MAPK.	Catechin	48-50	mitogen-activated protein kinase 14	Mus musculus	80-88
30358831-5	2018	Results: Consumption of DP1-10, but not of either DP2-10 or the control capsule, significantly increased flow-mediated vasodilation (primary endpoint) and the concentration of structurally related (-)-epicatechin metabolites (SREMs) in the circulatory system while decreasing pulse wave velocity and blood pressure.	Catechin	197-212	prostaglandin D2 receptor	Homo sapiens	24-30
30622947-15	2018	Results indicate that (-)-epicatechin supplementation does not affect myostatin gene expression or anaerobic training adaptations but inhibits aerobic and mitochondrial SDH adaptations to cycle exercise training.	Catechin	22-37	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	169-172
30469543-3	2018	This study aimed to evaluate the effects of the natural flavonoid taxifolin, luteolin, (-)-gallocatechin, and (-)-catechin on human P-gp activity.	Catechin	110-122	ATP binding cassette subfamily B member 1	Homo sapiens	132-136
30372853-11	2018	Circulatory MMP-9 levels were significantly decreased (p &lt; 0.001) in catechin treated animals at a dose of 50 mg/kg.	Catechin	72-80	matrix metallopeptidase 9	Rattus norvegicus	12-17
30399544-9	2018	Among them, three TFs homologous to ANL2, WRKY44 and AtMYB113 might play key roles in catechin regulation.	Catechin	86-94	myb domain protein 113	Arabidopsis thaliana	53-61
30555570-5	2018	Western blotting analysis was used to study the effect of Dextran-Catechin on the expression of CTR1 in neuroblastoma cell lines and in tumors.	Catechin	66-74	solute carrier family 31 member 1	Homo sapiens	96-100
30555570-9	2018	Treatment of neuroblastoma cell lines with Dextran-Catechin resulted in decreased levels of glutathione and in downregulation of CTR1 expression, which caused a significant decrease of intracellular copper.	Catechin	51-59	solute carrier family 31 member 1	Homo sapiens	129-133
30555570-13	2018	Ex vivo analysis of tumors collected from Dextran-Catechin treated mice confirmed the reduced levels of CTR1.	Catechin	50-58	solute carrier family 31, member 1	Mus musculus	104-108
30143409-6	2018	By Western blot analysis, it was shown, and increment in the phosphorylation level of eNOS and PI3K/AKT/mTOR/p70S6K proteins in the heart of the (-)-epicatechin treated animals.	Catechin	149-160	thymoma viral proto-oncogene 1	Mus musculus	100-103
31223207-0	2018	Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.	Catechin	30-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
31223207-8	2018	Thus, we report the binding properties of cianidanol with HER2+.	Catechin	42-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	58-62
30143409-6	2018	By Western blot analysis, it was shown, and increment in the phosphorylation level of eNOS and PI3K/AKT/mTOR/p70S6K proteins in the heart of the (-)-epicatechin treated animals.	Catechin	149-160	mechanistic target of rapamycin kinase	Mus musculus	104-108
30143409-6	2018	By Western blot analysis, it was shown, and increment in the phosphorylation level of eNOS and PI3K/AKT/mTOR/p70S6K proteins in the heart of the (-)-epicatechin treated animals.	Catechin	149-160	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	109-115
30375449-7	2018	Analysis of metabolites, contributing to the discrimination and prediction of the bioactivity of cultivars, showed that O-methylated catechins, epicatechin-3-O-(3-O-methyl) gallate (ECG3"Me) and epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me), were newly identified alpha-glucosidase inhibitors.	Catechin	133-142	sucrase isomaltase (alpha-glucosidase)	Mus musculus	271-288
29464499-7	2018	Administration of catechin attenuated CHD by reversing the levels of creatine kinase, creatine kinase-MB, lactate dehydrogenase, cardiac troponin (cTnT), ventricular ejection fraction (LVEF) and systolic internal diameter (LVIDs).	Catechin	18-26	troponin T2, cardiac type	Rattus norvegicus	147-151
30307946-3	2018	In this study, we investigated the interactions between human serum albumin (HSA) and various catechins, including some with a galloyl group, by means of isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and docking simulations.	Catechin	94-103	albumin	Homo sapiens	62-75
30246823-0	2018	Roasting improves the hypoglycemic effects of a large-leaf yellow tea infusion by enhancing the levels of epimerized catechins that inhibit alpha-glucosidase.	Catechin	117-126	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
30344490-6	2018	Results: Compounds with potential to promote anti-CCL17 production in HaCaT were identified (e.g., berberine, pyrogallol and catechin dimers) as a result of the developed model and their potential to act as anti-inflammatory agents were also supported by relevant literature.	Catechin	125-133	C-C motif chemokine ligand 17	Homo sapiens	50-55
29464499-9	2018	In contrast to nuclear factor-kappa beta (NF-kappaB), several proteins involved in inflammation such as farnesoid X receptor, signal transducers and activators of transcription (STAT)-3 and protein kinase B (PKB/Akt) were all activated by catechin.	Catechin	239-247	signal transducer and activator of transcription 3	Rattus norvegicus	126-185
29464499-10	2018	Catechin could be used as a promising treatment for CHD based on its role in suppressing inflammation and balancing STAT-3 signaling.	Catechin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	116-122
29603240-7	2018	RESULTS: During storage at -1.5 +- 0.2  C for 25 days, the SS-IG approach using 5 g L-1 chitosan and 1~3 g L-1 catechin as IG layers can effectively enhance the postmortem quality of preserved tilapia fillets.	Catechin	111-119	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
29981789-5	2018	EC and DHPAA pre-treatment also avoided the inactivation of the PI3K/AKT pathway and AMPK, and the elevation of PEPCK levels induced by high glucose.	Catechin	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	69-72
29981789-5	2018	EC and DHPAA pre-treatment also avoided the inactivation of the PI3K/AKT pathway and AMPK, and the elevation of PEPCK levels induced by high glucose.	Catechin	0-2	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	112-117
29981789-6	2018	Additionally, EC and DHPAA pre-treatment alleviated the altered glucose uptake and production caused by high glucose, although this protective effect was abrogated when AKT and AMPK were inhibited.	Catechin	14-16	AKT serine/threonine kinase 1	Rattus norvegicus	169-172
30129961-9	2018	Aging increased total protein and synthase acetylation levels and (-)-epicatechin partially restored them to those of young cells by stimulating sirtuin-1 binding to the synthase.	Catechin	66-81	sirtuin 1	Rattus norvegicus	145-154
30129961-10	2018	Phosphorylated sirtuin-1, mitofilin, oxidative phosphorylation complexes and transcriptional factor for mitochondria were reduced by ~40% with aging and were restored by (-)-epicatechin.	Catechin	170-185	sirtuin 1	Rattus norvegicus	15-24
30129961-10	2018	Phosphorylated sirtuin-1, mitofilin, oxidative phosphorylation complexes and transcriptional factor for mitochondria were reduced by ~40% with aging and were restored by (-)-epicatechin.	Catechin	170-185	inner membrane mitochondrial protein	Rattus norvegicus	26-35
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	heat shock protein family B (small) member 1	Rattus norvegicus	97-118
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	heat shock protein family B (small) member 1	Rattus norvegicus	120-125
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	interleukin 1 beta	Rattus norvegicus	191-199
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	interleukin 6	Rattus norvegicus	201-205
30373863-1	2018	OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats.	Catechin	67-75	tumor necrosis factor	Rattus norvegicus	210-219
30373863-7	2018	RESULTS: HSP27 levels increased in STZ-induced DR rats, and became further upregulated after catechin treatment.	Catechin	93-101	heat shock protein family B (small) member 1	Rattus norvegicus	9-14
30373863-8	2018	Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin.	Catechin	170-178	interleukin 1 beta	Rattus norvegicus	13-21
30373863-8	2018	Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin.	Catechin	170-178	interleukin 6	Rattus norvegicus	23-27
30373863-8	2018	Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin.	Catechin	170-178	tumor necrosis factor	Rattus norvegicus	33-42
30373863-10	2018	CONCLUSION: Catechin can weaken DR induced by STZ by increasing HSP27 levels and decreasing the production of associated inflammatory factors.	Catechin	12-20	heat shock protein family B (small) member 1	Rattus norvegicus	64-69
29964016-0	2018	Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity of mice.	Catechin	72-81	taste receptor, type 2, member 125	Mus musculus	0-8
29964016-6	2018	Because the response profiles of Tas2r125 were consistent with the results of the behavior assays, it was considered that Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity.	Catechin	194-203	taste receptor, type 2, member 125	Mus musculus	33-41
29964016-6	2018	Because the response profiles of Tas2r125 were consistent with the results of the behavior assays, it was considered that Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity.	Catechin	194-203	taste receptor, type 2, member 125	Mus musculus	122-130
29964016-10	2018	Therefore, Tas2r125 was considered to mainly function in the events of catechin reception in the oral cavity.	Catechin	71-79	taste receptor, type 2, member 125	Mus musculus	11-19
29206487-1	2018	The treatment of human pulmonary artery smooth muscle cells with ET-1 stimulates the activity of PLD and NADPH oxidase, but this stimulation is inhibited by pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor), and EGCG and ECG (catechins having a galloyl group), but not EGC and EC (catechins devoid of a galloyl group).	Catechin	343-352	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
30126206-0	2018	Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth.	Catechin	10-18	CD274 molecule	Homo sapiens	79-84
29206487-0	2018	Role of catechins on ET-1-induced stimulation of PLD and NADPH oxidase activities in pulmonary smooth muscle cells: determination of the probable mechanism by molecular docking studies.	Catechin	8-17	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	49-52
29206487-1	2018	The treatment of human pulmonary artery smooth muscle cells with ET-1 stimulates the activity of PLD and NADPH oxidase, but this stimulation is inhibited by pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor), and EGCG and ECG (catechins having a galloyl group), but not EGC and EC (catechins devoid of a galloyl group).	Catechin	343-352	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	218-221
29206487-1	2018	The treatment of human pulmonary artery smooth muscle cells with ET-1 stimulates the activity of PLD and NADPH oxidase, but this stimulation is inhibited by pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor), and EGCG and ECG (catechins having a galloyl group), but not EGC and EC (catechins devoid of a galloyl group).	Catechin	288-297	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
29206487-1	2018	The treatment of human pulmonary artery smooth muscle cells with ET-1 stimulates the activity of PLD and NADPH oxidase, but this stimulation is inhibited by pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor), and EGCG and ECG (catechins having a galloyl group), but not EGC and EC (catechins devoid of a galloyl group).	Catechin	288-297	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	218-221
29206487-2	2018	Herein, using molecular docking analyses based on our biochemical studies, we determined the probable mechanism by which the catechins containing a galloyl group inhibit the stimulation of PLD activity induced by ET-1.	Catechin	125-134	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	189-192
29206487-6	2018	The molecular docking analyses revealed that the catechins containing a galloyl group (EGCG and ECG) with cytohesin-1-Arf6GDP, but not the catechins without a galloyl group (EGC and EC), prevent GDP-GTP exchange in Arf6, which seems to be an important mechanism for inhibiting the activation of PLD induced by ET-1, and subsequently increases the activity of NADPH oxidase.	Catechin	49-58	cytohesin 1	Homo sapiens	106-125
29206487-6	2018	The molecular docking analyses revealed that the catechins containing a galloyl group (EGCG and ECG) with cytohesin-1-Arf6GDP, but not the catechins without a galloyl group (EGC and EC), prevent GDP-GTP exchange in Arf6, which seems to be an important mechanism for inhibiting the activation of PLD induced by ET-1, and subsequently increases the activity of NADPH oxidase.	Catechin	49-58	ADP ribosylation factor 6	Homo sapiens	118-122
29206487-6	2018	The molecular docking analyses revealed that the catechins containing a galloyl group (EGCG and ECG) with cytohesin-1-Arf6GDP, but not the catechins without a galloyl group (EGC and EC), prevent GDP-GTP exchange in Arf6, which seems to be an important mechanism for inhibiting the activation of PLD induced by ET-1, and subsequently increases the activity of NADPH oxidase.	Catechin	49-58	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	295-298
29894863-5	2018	For that, we try to research the treatment of catechin for allergic rhinitis and found out possible mechanism under this effect, which was based on TSLP factor.	Catechin	46-54	thymic stromal lymphopoietin	Mus musculus	148-152
29247373-0	2018	(-)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of beta1 adrenoceptor via GRK2 in experimental heart failure.	Catechin	12-20	adrenoceptor beta 1	Rattus norvegicus	95-113
29247373-0	2018	(-)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of beta1 adrenoceptor via GRK2 in experimental heart failure.	Catechin	12-20	G protein-coupled receptor kinase 2	Rattus norvegicus	118-122
29894863-12	2018	Catechin could reduce the levels of interleukin-5, interleukin-13, and ovalbumin-specific immunoglobulin-E in the serum and restored the T helper type 2/T helper type 1 cell balance and also had anti-thymic stromal lymphopoietin effects.	Catechin	0-8	interleukin 5	Mus musculus	36-49
29894863-12	2018	Catechin could reduce the levels of interleukin-5, interleukin-13, and ovalbumin-specific immunoglobulin-E in the serum and restored the T helper type 2/T helper type 1 cell balance and also had anti-thymic stromal lymphopoietin effects.	Catechin	0-8	interleukin 13	Mus musculus	51-65
29894863-13	2018	Moreover, as an upstream regulator of TSLP, the NF-kappaB signal pathway was also suppressed after catechin treatment, which was demonstrated by the observed decrease in phospho-NF-kappaBp65 and NF-kappaBp65 levels and the reduction of IkappaBalpha degradation and NF-kappaBp65 nuclear translocation.	Catechin	99-107	thymic stromal lymphopoietin	Mus musculus	38-42
29894863-13	2018	Moreover, as an upstream regulator of TSLP, the NF-kappaB signal pathway was also suppressed after catechin treatment, which was demonstrated by the observed decrease in phospho-NF-kappaBp65 and NF-kappaBp65 levels and the reduction of IkappaBalpha degradation and NF-kappaBp65 nuclear translocation.	Catechin	99-107	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	236-248
29894863-15	2018	The underlying mechanism is that catechin inhibited the expression of TSLP in epithelial cells by influencing NF-kappaB/TSLP pathway.	Catechin	33-41	thymic stromal lymphopoietin	Mus musculus	70-74
29894863-15	2018	The underlying mechanism is that catechin inhibited the expression of TSLP in epithelial cells by influencing NF-kappaB/TSLP pathway.	Catechin	33-41	thymic stromal lymphopoietin	Mus musculus	120-124
30036972-6	2018	Furthermore, catechin and procyanidin A2 could inhibit Abeta-induced apoptosis in BV-2 cells by upregulating Bcl-2 and downregulating Bax protein expression.	Catechin	13-21	B cell leukemia/lymphoma 2	Mus musculus	109-114
29759183-0	2018	Evaluation of thrombin inhibitory activity of catechins by online capillary electrophoresis-based immobilized enzyme microreactor and molecular docking.	Catechin	46-55	coagulation factor II, thrombin	Homo sapiens	14-22
29759183-5	2018	Then the prepared IMER was used to investigate the inhibitory potency on THR of four main catechins in green tea including epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG), and epigallocatechin gallate (EGCG).	Catechin	90-99	coagulation factor II, thrombin	Homo sapiens	73-76
29759183-7	2018	Additionally, molecular docking results showed that the benzopyran groups of ECG and EGCG were inserted into the THR active pocket and interacted with residues LYS60F, TRP60D, TRY60A, IEU99, GLY216, HIS57 and SER195, but EC and EGC did not.	Catechin	77-79	coagulation factor II, thrombin	Homo sapiens	113-116
30036972-6	2018	Furthermore, catechin and procyanidin A2 could inhibit Abeta-induced apoptosis in BV-2 cells by upregulating Bcl-2 and downregulating Bax protein expression.	Catechin	13-21	BCL2-associated X protein	Mus musculus	134-137
29658565-0	2018	(-)-Epicatechin protects against myocardial ischemia-induced cardiac injury via activation of the PTEN/PI3K/AKT pathway.	Catechin	0-15	phosphatase and tensin homolog	Mus musculus	98-102
30037024-4	2018	Experimental studies have reported that tea catechins inhibited influenza viral adsorption and suppressed replication and neuraminidase activity.	Catechin	44-53	neuraminidase 1	Homo sapiens	122-135
30029527-0	2018	Combined Supplementation of Pre-Exercise Carbohydrate, Alanine, and Proline and Continuous Intake of Green Tea Catechins Effectively Boost Endurance Performance in Mice.	Catechin	111-120	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	107-110
30029527-1	2018	Continuous intake of green tea catechins (GTC) increases fatty acid utilization as an energy source and improves endurance capacity.	Catechin	31-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	27-30
31949700-11	2018	Catechin activated the JNK pathway in H9c2 cells by down-regulating miR-92a.	Catechin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	23-26
31949700-12	2018	Conclusion: Catechin protected H9c2 cells from hypoxia-induced injury by regulating miR-92a and JNK signaling pathway.	Catechin	12-20	mitogen-activated protein kinase 8	Rattus norvegicus	96-99
29874868-8	2018	The flavonoids (-)-epigallocatechin (5) and (-)-epicatechin (6) exhibited prominent hepatoprotective activities with higher cell viability values (65.53% and 62.40% at 10 muM mL-1, respectively) than the positive control, silymarin (61.85% at 10 muM mL-1).	Catechin	44-59	L1 cell adhesion molecule	Mus musculus	175-179
29874868-8	2018	The flavonoids (-)-epigallocatechin (5) and (-)-epicatechin (6) exhibited prominent hepatoprotective activities with higher cell viability values (65.53% and 62.40% at 10 muM mL-1, respectively) than the positive control, silymarin (61.85% at 10 muM mL-1).	Catechin	44-59	L1 cell adhesion molecule	Mus musculus	250-254
29658565-0	2018	(-)-Epicatechin protects against myocardial ischemia-induced cardiac injury via activation of the PTEN/PI3K/AKT pathway.	Catechin	0-15	thymoma viral proto-oncogene 1	Mus musculus	108-111
29725928-5	2018	The LC-DAD analysis showed that catechins were the major phenolic compounds in samples, with epigallocatechin levels up to 138.62 mg mL-1.	Catechin	32-41	L1 cell adhesion molecule	Mus musculus	133-137
29604256-0	2018	Undesirable impact on structure and stability of insulin on addition of (+)-catechin hydrate with sugar.	Catechin	72-84	insulin	Homo sapiens	49-56
29417944-9	2018	These results demonstrate that EC at a physiological concentration promotes GSIS in SFA-impaired beta-cells via activation of the CaMKII pathway and is consistent with its function as a GPR40 ligand.	Catechin	31-33	free fatty acid receptor 1	Rattus norvegicus	186-191
29608879-0	2018	(-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells.	Catechin	0-15	insulin	Homo sapiens	111-118
29608879-2	2018	The flavanol-3-ol (-)-epicatechin (EC) can improve insulin sensitivity both in humans and animal models of T2D.	Catechin	18-33	insulin	Homo sapiens	51-58
29608879-2	2018	The flavanol-3-ol (-)-epicatechin (EC) can improve insulin sensitivity both in humans and animal models of T2D.	Catechin	35-37	insulin	Homo sapiens	51-58
29608879-4	2018	This study investigated the capacity of EC and EC metabolites (ECM) to downregulate NADPH oxidases and oxidative stress, and its association to an improvement of insulin sensitivity.	Catechin	40-42	insulin	Homo sapiens	162-169
29608879-4	2018	This study investigated the capacity of EC and EC metabolites (ECM) to downregulate NADPH oxidases and oxidative stress, and its association to an improvement of insulin sensitivity.	Catechin	47-49	insulin	Homo sapiens	162-169
29458270-0	2018	The involvement of Nrf2 antioxidant signalling pathway in the protection of monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats by (+)-catechin hydrate.	Catechin	149-161	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-23
29368187-1	2018	PURPOSE: The objective of this study is to assess the effects of green tea and its major catechin component, (-)-epigallocatechin gallate (EGCG), on CYP2C9-mediated substrate metabolism in vitro, and the pharmacokinetics of fluvastatin in healthy volunteers.	Catechin	89-97	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	149-155
29278988-7	2018	Lupeol and (+)-catechin showed cytotoxic activity against MCF-7 cell lines with IC50 values of 22.6 and 29.8 microg mL-1, respectively and greater cytotoxic activity against Caco-2 cell lines with IC50 values of 10.7 and 9.0 microg mL-1, respectively.	Catechin	11-23	L1 cell adhesion molecule	Mus musculus	116-120
29278988-7	2018	Lupeol and (+)-catechin showed cytotoxic activity against MCF-7 cell lines with IC50 values of 22.6 and 29.8 microg mL-1, respectively and greater cytotoxic activity against Caco-2 cell lines with IC50 values of 10.7 and 9.0 microg mL-1, respectively.	Catechin	11-23	L1 cell adhesion molecule	Mus musculus	232-236
29458270-3	2018	This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signalling pathway in the protection of (+)-catechin hydrate (CAT) against monocrotaline (MCT)-induced HSOS.	Catechin	153-173	NFE2 like bZIP transcription factor 2	Rattus norvegicus	50-93
29458270-3	2018	This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signalling pathway in the protection of (+)-catechin hydrate (CAT) against monocrotaline (MCT)-induced HSOS.	Catechin	153-173	NFE2 like bZIP transcription factor 2	Rattus norvegicus	95-99
29744232-4	2018	In this study, affinity capillary electrophoresis (ACE) and in silico molecular docking methods were developed to study the interaction between thrombin and ten phenolic compounds (p-hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid, catechin, epicatechin, dihydroquercetin, naringenin, apigenin, and baicalein).	Catechin	253-261	coagulation factor II, thrombin	Homo sapiens	144-152
29154190-0	2018	(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.	Catechin	0-15	insulin	Homo sapiens	124-131
29154190-3	2018	This study investigated whether dietary (-)-epicatechin (EC) supplementation can protect the intestinal barrier against HFD-induced permeabilization and endotoxemia, and mitigate liver damage and insulin resistance.	Catechin	40-55	insulin	Homo sapiens	196-203
29154190-3	2018	This study investigated whether dietary (-)-epicatechin (EC) supplementation can protect the intestinal barrier against HFD-induced permeabilization and endotoxemia, and mitigate liver damage and insulin resistance.	Catechin	57-59	insulin	Homo sapiens	196-203
29588626-4	2018	Thus, the current study investigated the growth inhibitory effect of EGCG and EC, on the enzyme expression and activity of the DNL pathway, which leads to the prominent activity of carnitine palmitoyl transferase-1 (CPT-1) mediating apoptosis in HepG2 cells.	Catechin	78-80	carnitine palmitoyltransferase 1A	Homo sapiens	181-214
29588626-4	2018	Thus, the current study investigated the growth inhibitory effect of EGCG and EC, on the enzyme expression and activity of the DNL pathway, which leads to the prominent activity of carnitine palmitoyl transferase-1 (CPT-1) mediating apoptosis in HepG2 cells.	Catechin	78-80	carnitine palmitoyltransferase 1A	Homo sapiens	216-221
29588626-12	2018	Herein, EGCG and EC inhibited the expression of FASN enzymes contributing to decreasing fatty acid levels.	Catechin	17-19	fatty acid synthase	Homo sapiens	48-52
29588626-14	2018	We suggest that epistructured catechin-induced apoptosis targets CPT-1 activity suppression mediated through diminishing the DNL pathway in HepG2 cells.	Catechin	30-38	carnitine palmitoyltransferase 1A	Homo sapiens	65-70
29392684-0	2018	Determining the Effect of Catechins on SOD1 Conformation and Aggregation by Ion Mobility Mass Spectrometry Combined with Optical Spectroscopy.	Catechin	26-35	superoxide dismutase 1	Homo sapiens	39-43
29392684-3	2018	In this study, ESI-MS was used to investigate the interaction of catechins and SOD1.	Catechin	65-74	superoxide dismutase 1	Homo sapiens	79-83
29392684-4	2018	The noncovalent complex of catechins that interact with SOD1 was found and retained in the gas phase under native ESI-MS condition.	Catechin	27-36	superoxide dismutase 1	Homo sapiens	56-60
29392684-5	2018	The conformation changes of SOD1 after binding with catechins were also explored via traveling wave ion mobility (IM) spectrometry.	Catechin	52-61	superoxide dismutase 1	Homo sapiens	28-32
29392684-6	2018	Epigallocatechin gallate (EGCG) can stabilize SOD1 conformation against unfolding in three catechins.	Catechin	91-100	superoxide dismutase 1	Homo sapiens	46-50
29703388-4	2018	Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus.	Catechin	53-62	solute carrier organic anion transporter family member 1A2	Homo sapiens	110-117
29703388-4	2018	Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus.	Catechin	53-62	solute carrier organic anion transporter family member 2B1	Homo sapiens	121-128
29703388-4	2018	Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus.	Catechin	53-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	183-188
29744232-4	2018	In this study, affinity capillary electrophoresis (ACE) and in silico molecular docking methods were developed to study the interaction between thrombin and ten phenolic compounds (p-hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid, catechin, epicatechin, dihydroquercetin, naringenin, apigenin, and baicalein).	Catechin	263-274	coagulation factor II, thrombin	Homo sapiens	144-152
29515203-6	2018	Catechin derivatives with galloyl moiety displayed significant inhibition potency against SIRT6 at 10 microM concentration.	Catechin	0-8	sirtuin 6	Homo sapiens	90-95
29429153-7	2018	Human CSCs are thus a target for cancer prevention and treatment with EGCG and green tea catechins.	Catechin	89-98	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	85-88
29407769-6	2018	Surface plasmon resonance was used to assess direct interaction between catechins and MT1-MMP interactors.	Catechin	72-81	matrix metallopeptidase 14	Homo sapiens	86-93
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	matrix metallopeptidase 14	Homo sapiens	86-93
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	matrix metallopeptidase 14	Homo sapiens	110-117
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	matrix metallopeptidase 2	Homo sapiens	135-140
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	TIMP metallopeptidase inhibitor 2	Homo sapiens	142-148
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	acireductone dioxygenase 1	Homo sapiens	150-157
29407769-7	2018	We found that gallated catechins interacted better than their ungallated analogs with MT1-MMP as well as with MT1-MMP binding partners MMP-2, TIMP-2, MTCBP-1 and LRP1-clusterIV.	Catechin	23-32	LDL receptor related protein 1	Homo sapiens	162-166
29407769-8	2018	Overall, current structure-function evidence supports a role for the galloyl moiety in both direct and indirect interactions of green tea catechins with MT1-MMP-mediated oncogenic processes.	Catechin	138-147	matrix metallopeptidase 14	Homo sapiens	153-160
29355558-0	2018	(-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor.	Catechin	0-15	G protein-coupled estrogen receptor 1	Mus musculus	94-129
29407769-0	2018	Biophysical evidence for differential gallated green tea catechins binding to membrane type-1 matrix metalloproteinase and its interactors.	Catechin	57-66	matrix metallopeptidase 14	Homo sapiens	78-118
29407769-2	2018	While green tea catechins, particularly epigallocatechin gallate (EGCG), are considered very effective in preventing MT1-MMP-mediated functions, lack of structure-function studies and evidence regarding their direct interaction with MT1-MMP-mediated biological activities remain.	Catechin	16-25	matrix metallopeptidase 14	Homo sapiens	117-124
29407769-2	2018	While green tea catechins, particularly epigallocatechin gallate (EGCG), are considered very effective in preventing MT1-MMP-mediated functions, lack of structure-function studies and evidence regarding their direct interaction with MT1-MMP-mediated biological activities remain.	Catechin	16-25	matrix metallopeptidase 14	Homo sapiens	233-240
29407769-3	2018	Here, we assessed the impact in both cellular and biophysical assays of four ungallated catechins along with their gallated counterparts on MT1-MMP-mediated functions and molecular binding partners.	Catechin	88-97	matrix metallopeptidase 14	Homo sapiens	140-147
29395974-0	2018	Synthesis of novel (-)-epicatechin derivatives as potential endothelial GPER agonists: Evaluation of biological effects.	Catechin	19-34	G protein-coupled estrogen receptor 1	Bos taurus	72-76
29205863-5	2018	Interestingly, EC and DHBA did not modify the levels of SGLT-2 and GLUT-2, and modulated the expression of phosphoenolpyruvate carboxykinase via AKT leading to a diminished glucose production.	Catechin	15-17	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
28958556-2	2018	Catechins showed the highest ABTS-scavenging capacity, the highest stoichiometry of Fe3+ reduction in the FRAP assay and belonged to the most efficient compounds in protection against SIN-1 induced oxidation of dihydrorhodamine 123, AAPH-induced fluorescein bleaching and hypochlorite-induced fluorescein bleaching.	Catechin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	106-110
28958556-2	2018	Catechins showed the highest ABTS-scavenging capacity, the highest stoichiometry of Fe3+ reduction in the FRAP assay and belonged to the most efficient compounds in protection against SIN-1 induced oxidation of dihydrorhodamine 123, AAPH-induced fluorescein bleaching and hypochlorite-induced fluorescein bleaching.	Catechin	0-9	MAPK associated protein 1	Homo sapiens	184-189
29355013-0	2018	Interaction between Ester-Type Tea Catechins and Neutrophil Gelatinase-Associated Lipocalin: Inhibitory Mechanism.	Catechin	35-44	lipocalin 2	Homo sapiens	49-91
29205863-6	2018	EC and DHBA also enhanced the tyrosine phosphorylation and total IR and IRS-1 levels, and activated the PI3K/AKT pathway in NRK-52E cells.	Catechin	0-2	insulin receptor	Rattus norvegicus	65-67
29205863-6	2018	EC and DHBA also enhanced the tyrosine phosphorylation and total IR and IRS-1 levels, and activated the PI3K/AKT pathway in NRK-52E cells.	Catechin	0-2	insulin receptor substrate 1	Rattus norvegicus	72-77
29205863-6	2018	EC and DHBA also enhanced the tyrosine phosphorylation and total IR and IRS-1 levels, and activated the PI3K/AKT pathway in NRK-52E cells.	Catechin	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
28980319-0	2017	Pharmacokinetic interaction of green tea beverage containing cyclodextrins and high concentration catechins with P-glycoprotein substrates in LLC-GA5-COL150 cells in vitro and in the small intestine of rats in vivo.	Catechin	98-107	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	113-127
29129733-5	2018	Viability assays on parental BE(2)C and resistant BE(2)C/ADR cell lines proved that the high anticancer activity of dextran-catechin conjugate (IC50 19.9 +- 0.6 and 18.4 +- 0.7 microg mL-1) was retained upon formation of the nanohybrids (IC50 24.8 +- 0.7 and 22.9 +- 1 microg mL-1).	Catechin	124-132	L1 cell adhesion molecule	Mus musculus	184-188
29129733-5	2018	Viability assays on parental BE(2)C and resistant BE(2)C/ADR cell lines proved that the high anticancer activity of dextran-catechin conjugate (IC50 19.9 +- 0.6 and 18.4 +- 0.7 microg mL-1) was retained upon formation of the nanohybrids (IC50 24.8 +- 0.7 and 22.9 +- 1 microg mL-1).	Catechin	124-132	L1 cell adhesion molecule	Mus musculus	276-280
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Catechin	106-115	catechol-O-methyltransferase	Homo sapiens	149-178
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Catechin	106-115	catechol-O-methyltransferase	Homo sapiens	180-184
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Catechin	234-243	catechol-O-methyltransferase	Homo sapiens	149-178
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Catechin	234-243	catechol-O-methyltransferase	Homo sapiens	180-184
28980319-1	2017	OBJECTIVES: Possible interaction of green tea beverage (GT) containing cyclodextrins and high concentration catechins, a drinking water, with P-glycoprotein (P-gp) substrates was examined in vitro and in vivo.	Catechin	108-117	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	142-156
28980319-1	2017	OBJECTIVES: Possible interaction of green tea beverage (GT) containing cyclodextrins and high concentration catechins, a drinking water, with P-glycoprotein (P-gp) substrates was examined in vitro and in vivo.	Catechin	108-117	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	158-162
28980319-7	2017	Thus, GT may cause interaction with various P-gp substrates, due to the combined effects of catechins and cyclodextrins.	Catechin	92-101	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	44-48
28863367-5	2017	INS-1 832/13-derived beta-cells and primary rat islets cultured with a monomeric catechin-rich cocoa flavanol fraction demonstrated enhanced glucose-stimulated insulin secretion, while cells cultured with total cocoa extract and with oligomeric or polymeric procyanidin-rich fraction demonstrated no improvement.	Catechin	81-89	insulin 1	Rattus norvegicus	0-5
27864733-0	2017	(-)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways.	Catechin	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
27864733-0	2017	(-)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways.	Catechin	0-15	jun proto-oncogene	Mus musculus	108-112
27864733-2	2017	Our previous research has shown that (-)-epicatechin treatment reduces hemorrhagic stroke injury via nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in vivo.	Catechin	37-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-144
27864733-2	2017	Our previous research has shown that (-)-epicatechin treatment reduces hemorrhagic stroke injury via nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in vivo.	Catechin	37-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
27864733-7	2017	(-)-Epicatechin increased Nrf2 nuclear accumulation and cytoplasmic levels of superoxide dismutase 1 (SOD1) in wild-type astrocytes but did not increase SOD1 expression in Nrf2 knockout (KO) astrocytes.	Catechin	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-30
27864733-7	2017	(-)-Epicatechin increased Nrf2 nuclear accumulation and cytoplasmic levels of superoxide dismutase 1 (SOD1) in wild-type astrocytes but did not increase SOD1 expression in Nrf2 knockout (KO) astrocytes.	Catechin	0-15	superoxide dismutase 1, soluble	Mus musculus	78-100
27864733-7	2017	(-)-Epicatechin increased Nrf2 nuclear accumulation and cytoplasmic levels of superoxide dismutase 1 (SOD1) in wild-type astrocytes but did not increase SOD1 expression in Nrf2 knockout (KO) astrocytes.	Catechin	0-15	superoxide dismutase 1, soluble	Mus musculus	102-106
27864733-8	2017	Furthermore, (-)-epicatechin treatment did not alter heme oxygenase 1 (HO1) expression in wild-type astrocytes after hemoglobin exposure, but it did decrease HO1 expression in similarly treated Nrf2 KO astrocytes.	Catechin	13-28	heme oxygenase 1	Mus musculus	158-161
27864733-8	2017	Furthermore, (-)-epicatechin treatment did not alter heme oxygenase 1 (HO1) expression in wild-type astrocytes after hemoglobin exposure, but it did decrease HO1 expression in similarly treated Nrf2 KO astrocytes.	Catechin	13-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	194-198
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	mitogen-activated protein kinase 8	Mus musculus	84-87
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	mitogen-activated protein kinase 8	Mus musculus	114-117
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	jun proto-oncogene	Mus musculus	119-124
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	FBJ osteosarcoma oncogene	Mus musculus	130-135
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	jun proto-oncogene	Mus musculus	167-186
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	jun proto-oncogene	Mus musculus	188-192
27864733-9	2017	In both wild-type and Nrf2 KO astrocytes, (-)-epicatechin suppressed phosphorylated JNK and nuclear expression of JNK, c-jun, and c-fos, indicating that inhibition of activator protein-1 (AP-1) activity by (-)-epicatechin is Nrf2-independent.	Catechin	42-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	225-229
27864733-10	2017	These novel findings indicate that (-)-epicatechin protects astrocytes against hemoglobin toxicity through upregulation of Nrf2 and inhibition of AP-1 activity.	Catechin	35-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
27864733-10	2017	These novel findings indicate that (-)-epicatechin protects astrocytes against hemoglobin toxicity through upregulation of Nrf2 and inhibition of AP-1 activity.	Catechin	35-50	jun proto-oncogene	Mus musculus	146-150
28825226-12	2017	Furthermore, transcription factors such as MYB, bHLH and MADS, which may involve in the regulation of catechins biosynthesis, were identified through co-expression analysis of transcription factors and structural genes.	Catechin	102-111	MYB proto-oncogene, transcription factor	Homo sapiens	43-46
29054360-1	2017	Proanthocyanidins are oligomers of catechins that exhibit potent antioxidative activity and inhibit binding of oxidized low-density lipoprotein (OxLDL) to the lectin-like oxidized LDL receptor (LOX-1), which is involved in the onset and development of arteriosclerosis.	Catechin	35-44	oxidized low density lipoprotein receptor 1	Homo sapiens	194-199
28768059-0	2017	(-)-Epicatechin rescues the As2 O3 -induced HERG K+ channel deficiency possibly through upregulating transcription factor SP1 expression.	Catechin	0-15	potassium voltage-gated channel subfamily H member 2	Homo sapiens	44-48
28844000-4	2017	It has been suggested that epigallocatechin gallate (EGCG), a member of the catechin family, might be an effective treatment for AD, because it has been shown to elevate NEP expression.	Catechin	35-43	membrane metalloendopeptidase	Homo sapiens	170-173
28844000-5	2017	Therefore, we examined whether catechins, which are functional components of common foods, could regulate the degradation of Abeta by inducing NEP and IDE expression.	Catechin	31-40	membrane metalloendopeptidase	Homo sapiens	143-146
28844000-5	2017	Therefore, we examined whether catechins, which are functional components of common foods, could regulate the degradation of Abeta by inducing NEP and IDE expression.	Catechin	31-40	insulin degrading enzyme	Homo sapiens	151-154
28668765-8	2017	In addition, Nrf2 translocation to the nucleus was greater in the 0.5% green tea catechin group than in the positive control group (P&lt;0.05).	Catechin	81-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
28969404-6	2017	RESULTS: Despite the statistically significant reduction of PSA observed in subjects who received green tea catechins for 6 and 12 months, we did not find any statistical difference in PCa incidence between the experimental groups neither after 6 nor after 12 months.	Catechin	108-117	kallikrein related peptidase 3	Homo sapiens	60-63
28668765-9	2017	CONCLUSIONS: Topical application of ointment containing 0.5% green tea catechins could prevent tongue oxidative stress in 5-FU administered rats, via up-regulation of the Nrf2 signaling pathway.	Catechin	71-80	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
27444711-6	2017	Combined exposure to caffeine and catechins significantly upregulated mRNA and protein expression levels of lipases while downregulating FAS mRNA expression and protein expression of peroxisome proliferator-activated receptor gamma2.	Catechin	34-43	fatty acid synthase	Mus musculus	137-140
28678393-11	2017	Catechin was shown to protect BBB integrity, alleviate the TBI-induced loss of the junction proteins occludin and zonula occludens protein-1 and suppress local inflammatory reactions.	Catechin	0-8	occludin	Rattus norvegicus	101-109
27444711-6	2017	Combined exposure to caffeine and catechins significantly upregulated mRNA and protein expression levels of lipases while downregulating FAS mRNA expression and protein expression of peroxisome proliferator-activated receptor gamma2.	Catechin	34-43	peroxisome proliferator activated receptor gamma	Mus musculus	183-232
28866888-0	2017	Additive Capacity of [6]-Shogaol and Epicatechin To Trap Methylglyoxal.	Catechin	37-48	acid phosphatase 5, tartrate resistant	Mus musculus	52-56
28490136-0	2017	Antioxidative capacity and binding affinity of the complex of green tea catechin and beta-lactoglobulin glycated by the Maillard reaction.	Catechin	72-80	beta-lactoglobulin	Bos taurus	85-103
28490136-1	2017	Major green tea catechin, epigallocatechin-3-gallate (EGCG), binds non-covalently to numerous dietary proteins, including beta-lactoglobulin of cow"s milk.	Catechin	16-24	beta-lactoglobulin	Bos taurus	122-140
28875706-4	2017	The combination of baicalein, quercetin, or luteolin with acarbose showed synergistic inhibition, and the combination of (+)-catechin with acarbose showed antagonistic inhibition of alpha-glucosidase.	Catechin	121-133	sucrase-isomaltase	Homo sapiens	182-199
28917147-8	2017	We show that catechins with galloyl group and molecules having two to three planar apolar rings bind to hIAPP structures and fibril forming segments with greater affinity.	Catechin	13-22	islet amyloid polypeptide	Homo sapiens	104-109
28544013-1	2017	We investigated the molecular mechanisms involved in the angiotensin-converting enzyme (ACE) inhibition by (-)-epigallocatechin-3-gallate (EGCg), a major tea catechin.	Catechin	119-127	angiotensin I converting enzyme	Homo sapiens	57-86
28544013-1	2017	We investigated the molecular mechanisms involved in the angiotensin-converting enzyme (ACE) inhibition by (-)-epigallocatechin-3-gallate (EGCg), a major tea catechin.	Catechin	119-127	angiotensin I converting enzyme	Homo sapiens	88-91
28372251-10	2017	Anthocyanidin reductase (ANR) transcripts, the enzyme responsible for epicatechin production, showed similar levels among samples.	Catechin	70-81	anthocyanidin reductase	Solanum tuberosum	0-23
28827527-0	2017	Bioactivity-Guided Fractionation of Pine Needle Reveals Catechin as an Anti-hypertension Agent via Inhibiting Angiotensin-Converting Enzyme.	Catechin	56-64	angiotensin I converting enzyme	Rattus norvegicus	110-139
28827527-6	2017	And we found out the compound in pine needle extracts being ACE-inhibitory active is catechin.	Catechin	85-93	angiotensin I converting enzyme	Rattus norvegicus	60-63
28827527-7	2017	When ACE activity was assayed in rat tissue membranes, it was observed that catechin demonstrate ACE inhibition in kidney, lung and testes tissue.	Catechin	76-84	angiotensin I converting enzyme	Rattus norvegicus	5-8
28827527-7	2017	When ACE activity was assayed in rat tissue membranes, it was observed that catechin demonstrate ACE inhibition in kidney, lung and testes tissue.	Catechin	76-84	angiotensin I converting enzyme	Rattus norvegicus	97-100
28372251-10	2017	Anthocyanidin reductase (ANR) transcripts, the enzyme responsible for epicatechin production, showed similar levels among samples.	Catechin	70-81	anthocyanidin reductase	Solanum tuberosum	25-28
28630292-5	2017	Here, the catechin-binding site of SULT1A3, which sulfonates monoamine neurotransmitters, is modeled on that of 1A1 and used to screen in silico for endogenous metabolite 1A3 allosteres.	Catechin	10-18	sulfotransferase family 1A member 3	Homo sapiens	35-42
28798415-7	2017	Furthermore, these epicatechin oligomers suppressed significantly the expression of the cancer-promoting gene, FABP5, which is related to cell proliferation and metastasis in various cancer cells.	Catechin	19-30	fatty acid binding protein 5	Homo sapiens	111-116
29370654-0	2017	Re: Mg(II)-Catechin Nanoparticles Delivering siRNA Targeting EIF5A2 Inhibit Bladder Cancer Cell Growth In Vitro and In Vivo.	Catechin	11-19	eukaryotic translation initiation factor 5A2	Mus musculus	61-67
28532672-0	2017	Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1beta signaling in rheumatoid arthritis synovial fibroblasts.	Catechin	85-94	interleukin 1 beta	Homo sapiens	98-106
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	interleukin 1 beta	Homo sapiens	112-120
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	interleukin 6	Homo sapiens	201-205
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
28532672-4	2017	When we looked at the expression of key signaling proteins in the IL-1beta signaling pathway, we found all the tested catechins could inhibit TAK-1 activity.	Catechin	118-127	interleukin 1 beta	Homo sapiens	66-74
28532672-4	2017	When we looked at the expression of key signaling proteins in the IL-1beta signaling pathway, we found all the tested catechins could inhibit TAK-1 activity.	Catechin	118-127	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	142-147
28721420-3	2017	Differential scanning calorimetry revealed that, in a low concentration regime (&lt;=10 muM), catechin molecules are not significantly incorporated into the hydrophobic core of lipid membranes as substitutional impurities.	Catechin	94-102	latexin	Homo sapiens	88-91
28546002-0	2017	Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration.	Catechin	0-9	myogenic factor 5	Mus musculus	40-44
28346686-1	2017	The ability of catechins and their related compounds to inhibit breast cancer resistance protein (BCRP) function in Caco-2 cell monolayers was investigated with mitoxantrone as a BCRP substrate.	Catechin	15-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	64-96
28422389-3	2017	Both of desferrioxamine and catechin could inhibit TIM nitration induced by heme-H2 O2 -NaNO2 and SIN-1 and protein oxidation induced by SIN-1, but promoted heme-H2 O2 -NaNO2 -induced protein oxidation.	Catechin	28-36	triosephosphate isomerase 1	Homo sapiens	51-54
28422389-3	2017	Both of desferrioxamine and catechin could inhibit TIM nitration induced by heme-H2 O2 -NaNO2 and SIN-1 and protein oxidation induced by SIN-1, but promoted heme-H2 O2 -NaNO2 -induced protein oxidation.	Catechin	28-36	MAPK associated protein 1	Homo sapiens	98-103
28422389-3	2017	Both of desferrioxamine and catechin could inhibit TIM nitration induced by heme-H2 O2 -NaNO2 and SIN-1 and protein oxidation induced by SIN-1, but promoted heme-H2 O2 -NaNO2 -induced protein oxidation.	Catechin	28-36	MAPK associated protein 1	Homo sapiens	137-142
27711962-2	2017	RESULTS: Among the polyphenols measured by liquid chromatography-mass spectroscopy in GP, in feed containing GP (GP+) or not containing GP (GP-), gallic acid and epicatechin were present in the highest concentrations (67.58 and 19.23 microg mL-1 , respectively).	Catechin	162-173	L1 cell adhesion molecule	Mus musculus	241-245
28611670-5	2017	(-)-Epigallocatechin-3-gallate (EGCG), the major natural catechins of green tea extract, was identified as a PGAM1 inhibitor that was tremendously more potent than known PGAM1 inhibitors.	Catechin	57-66	phosphoglycerate mutase 1	Homo sapiens	109-114
28346686-1	2017	The ability of catechins and their related compounds to inhibit breast cancer resistance protein (BCRP) function in Caco-2 cell monolayers was investigated with mitoxantrone as a BCRP substrate.	Catechin	15-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	98-102
28346686-8	2017	The co-administration of catechins, particularly EGCG and related compounds, with greater hydrophobicity may increase the therapeutic activities of BCRP substrates such as mitoxantrone.	Catechin	25-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	148-152
28384253-0	2017	Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.	Catechin	0-11	myogenic differentiation 1	Homo sapiens	20-24
27883924-1	2017	Green tea catechins (GTCs) are known to improve fat oxidation (FOX) during fasted, rested and exercise conditions wherein epigallocatechin-3-gallate (EGCG) is thought to be the most pharmacologically active and has been studied extensively.	Catechin	10-19	FAT atypical cadherin 1	Homo sapiens	48-51
28384253-5	2017	EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt.	Catechin	0-2	AKT serine/threonine kinase 1	Homo sapiens	131-134
28384253-6	2017	EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein.	Catechin	0-2	myogenic differentiation 1	Homo sapiens	22-26
28103535-0	2017	Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.	Catechin	207-215	histone deacetylase 4	Homo sapiens	19-51
26704714-6	2017	METHODS: Human monocytic cells (THP-1 cells) were pre-treated with EC (5 muM) and 4 h later exposed to 25 mM glucose (HG) for a total of 24 h. Control cells were grown under normoglycemic conditions (NG, 5.5 mM glucose).	Catechin	67-69	latexin	Homo sapiens	73-76
26704714-11	2017	EC also significantly decreased HG-enhanced HDAC4 levels and TNF-alpha release, respectively.	Catechin	0-2	histone deacetylase 4	Homo sapiens	44-49
26704714-11	2017	EC also significantly decreased HG-enhanced HDAC4 levels and TNF-alpha release, respectively.	Catechin	0-2	tumor necrosis factor	Homo sapiens	61-70
28335502-6	2017	Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-kappaB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways.	Catechin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	207-229
26613119-6	2017	RESULTS: Among the natural compounds that show antidepressive-like activity, green tea catechins have been shown to decrease depressive symptoms in experimental animals, possibly in part through the inhibition of monoamine oxidase (MAO).	Catechin	87-96	monoamine oxidase A	Rattus norvegicus	213-230
26613119-6	2017	RESULTS: Among the natural compounds that show antidepressive-like activity, green tea catechins have been shown to decrease depressive symptoms in experimental animals, possibly in part through the inhibition of monoamine oxidase (MAO).	Catechin	87-96	monoamine oxidase A	Rattus norvegicus	232-235
28039839-6	2017	Pretreatment with dietary (-)-epicatechin prevented the adverse effects of LPS challenge essentially by inhibiting TLR4 upregulation and NOX activation and the consequent downstream events, e.g. NF-kB activation.	Catechin	26-41	toll-like receptor 4	Rattus norvegicus	115-119
28231705-6	2017	Importantly, the study demonstrates that C-8 addition products of (+)-catechin are promoted by Cu(II), whereas C-6 addition products are promoted by Fe ions.	Catechin	66-78	homeobox C8	Homo sapiens	41-44
28345531-6	2017	Catechins cause an increase in the activity of endothelial nitric oxide synthase (eNOS) and increased production of nitric oxide (NO) and decrease in blood pressure.	Catechin	0-9	nitric oxide synthase 3	Homo sapiens	47-80
28345531-7	2017	Catechins also reduce platelet adhesion, lower the concentration of C-reactive protein and tumor necrosis factor alpha and interleukin-6.	Catechin	0-9	interleukin 6	Homo sapiens	123-136
28335502-6	2017	Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-kappaB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways.	Catechin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	231-240
28335502-6	2017	Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-kappaB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways.	Catechin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	307-350
28335502-6	2017	Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-kappaB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways.	Catechin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	352-356
28335502-6	2017	Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-kappaB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways.	Catechin	13-22	signal transducer and activator of transcription 1	Homo sapiens	417-424
28273866-6	2017	A molecular docking study was conducted to determine how the FTE"s principal catechins interact with the tyrosinase.	Catechin	77-86	tyrosinase	Rattus norvegicus	105-115
28273866-10	2017	The docking results were consistent with our in vitro data, indicating the anti-tyrosinase potency of the principal catechins.	Catechin	116-125	tyrosinase	Rattus norvegicus	80-90
28013477-0	2017	Inhibition of pro-/active MMP-2 by green tea catechins and prediction of their interaction by molecular docking studies.	Catechin	45-54	matrix metallopeptidase 2	Homo sapiens	26-31
26658763-0	2017	N- and S-homocysteinylation reduce the binding of human serum albumin to catechins.	Catechin	73-82	albumin	Homo sapiens	56-69
28013477-3	2017	Our present study revealed that among the four green tea catechins (EGCG, ECG, EC, and EGC), EGCG and ECG inhibit pro-/active MMP-2 activities in pulmonary artery smooth muscle cell (PASMC) culture supernatant.	Catechin	57-66	matrix metallopeptidase 2	Homo sapiens	126-131
28013477-4	2017	Based on the above, we investigated the interactions of pro-/active MMP-2 with the green tea catechins by computational methods.	Catechin	93-102	matrix metallopeptidase 2	Homo sapiens	68-73
28013477-7	2017	Importantly, these two catechins appeared to be better inhibitors for proMMP-2 in comparison to MMP-2 as revealed by gelatin zymogram and also by molecular docking studies.	Catechin	23-32	matrix metallopeptidase 2	Homo sapiens	73-78
28013477-9	2017	We, therefore, determined the interactions of MT1-MMP with the green tea catechins by molecular docking analysis.	Catechin	73-82	matrix metallopeptidase 14	Homo sapiens	46-53
28062181-0	2017	Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance.	Catechin	0-11	chemokine (C-C motif) ligand 19	Mus musculus	41-46
27605464-0	2017	(-)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice.	Catechin	0-15	thymoma viral proto-oncogene 1	Mus musculus	79-82
28218710-0	2017	Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin.	Catechin	36-45	albumin	Homo sapiens	97-110
28218710-1	2017	It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin.	Catechin	17-26	albumin	Homo sapiens	98-111
28218710-2	2017	In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA).	Catechin	23-31	albumin	Homo sapiens	156-175
28218710-2	2017	In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA).	Catechin	23-31	albumin	Homo sapiens	156-169
28218710-2	2017	In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA).	Catechin	81-89	albumin	Homo sapiens	156-175
28218710-2	2017	In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA).	Catechin	81-89	albumin	Homo sapiens	156-169
28218710-9	2017	In conclusion, substitution at the C-3 position of catechins has an important influence on the binding affinity against serum albumin.	Catechin	51-60	albumin	Homo sapiens	120-133
28212288-7	2017	Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity.	Catechin	69-78	paraoxonase 1	Mus musculus	140-144
28049293-2	2017	We applied solution small-angle X-ray scattering (SAXS) to study the complex structure of bovine serum albumin (BSA) and trypsin binding with tea polyphenols, that is, catechin and epigallocatechin gallate (EGCG).	Catechin	168-176	albumin	Homo sapiens	97-116
28420000-0	2017	(-)-Epicatechin Suppresses Angiotensin II-induced Cardiac Hypertrophy via the Activation of the SP1/SIRT1 Signaling Pathway.	Catechin	0-15	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	27-41
28420000-0	2017	(-)-Epicatechin Suppresses Angiotensin II-induced Cardiac Hypertrophy via the Activation of the SP1/SIRT1 Signaling Pathway.	Catechin	0-15	sirtuin 1	Mus musculus	100-105
28582855-7	2017	Studies also show that catechins may prevent the formation of amyloid-beta plaques and enhance cognitive functions, and thus may be useful in treating patients who have Alzheimer"s disease or dementia.	Catechin	23-32	amyloid beta precursor protein	Homo sapiens	62-74
27562352-5	2016	Catechin beverage consumption was associated with a significantly higher ventilation threshold during exercise and a higher recovery rate of oxygenated hemoglobin and myoglobin levels after graded cycle exercise when compared to subjects receiving the placebo beverage.	Catechin	0-8	myoglobin	Homo sapiens	167-176
29161690-0	2017	Catechins Blunt the Effects of oxLDL and its Primary Metabolite Phosphatidylcholine Hydroperoxide on Endothelial Dysfunction Through Inhibition of Oxidative Stress and Restoration of eNOS in Rats.	Catechin	0-9	nitric oxide synthase 3	Rattus norvegicus	183-187
29161690-6	2017	Catechins pretreatment significantly reduced PCOOH-elevated H2O2 amounts, endothelial cell apoptosis and partly recovered eNOS expression.	Catechin	0-9	nitric oxide synthase 3	Rattus norvegicus	122-126
29161690-9	2017	The increased plasma catechins significantly inhibited oxLDL-, PCOOH- or H2O2-induced renal and aortic vasoconstriction, decreased urinary 8-isoprostane levels, renal ICAM-1 expression and 4-HNE accumulation, and restored nitrite/nitrate amounts and eNOS activity.	Catechin	21-30	intercellular adhesion molecule 1	Rattus norvegicus	167-173
29161690-9	2017	The increased plasma catechins significantly inhibited oxLDL-, PCOOH- or H2O2-induced renal and aortic vasoconstriction, decreased urinary 8-isoprostane levels, renal ICAM-1 expression and 4-HNE accumulation, and restored nitrite/nitrate amounts and eNOS activity.	Catechin	21-30	nitric oxide synthase 3	Rattus norvegicus	250-254
29161690-10	2017	CONCLUSIONS: Our data suggests that catechins pretreatment decrease PCOOH-induced endothelial apoptosis and arterial vasoconstriction through the action of H2O2 inhibition and eNOS restoration.	Catechin	36-45	nitric oxide synthase 3	Rattus norvegicus	176-180
27911811-0	2016	The structure of the catechin-binding site of human sulfotransferase 1A1.	Catechin	21-29	sulfotransferase family 1A member 1	Homo sapiens	52-72
27911811-2	2016	SULT1A1, the predominant isoform in adult liver, harbors two noninteracting allosteric sites, each of which binds a different molecular family: the catechins (naturally occurring flavonols) and nonsteroidal antiinflammatory drugs (NSAIDs).	Catechin	148-157	sulfotransferase family 1A member 1	Homo sapiens	0-7
27911811-3	2016	Here, we present the structure of an SULT allosteric binding site-the catechin-binding site of SULT1A1 bound to epigallocatechin gallate (EGCG).	Catechin	70-78	sulfotransferase family 1A member 1	Homo sapiens	95-102
28479727-4	2017	OBJECTIVE: The present study was designed to explore the antioxidant property of (-)-epicatechin isolated from PN in D-Galactosamine (D-GalN) induced hepatitis rats.	Catechin	81-96	galanin and GMAP prepropeptide	Rattus norvegicus	136-140
28479727-9	2017	Whereas GST, ALP, AST, ALT activities and MDA, and bilirubin levels are elevated in hepatitis rats, (-)-epicatechin pretreatment increased all the antioxidant enzymes and decreased the GST, ALP, AST, ALT, and MDA levels in hepatitis rats.	Catechin	100-115	PDZ and LIM domain 3	Rattus norvegicus	190-193
27668533-0	2016	Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis.	Catechin	33-42	matrix metallopeptidase 9	Homo sapiens	14-19
27668533-3	2016	The present study demonstrated that among the four green tea catechins (EGCG, ECG, EC and EGC), EGCG and ECG inhibit pro-/active MMP-9 activities in pulmonary artery smooth muscle cell culture supernatant.	Catechin	61-70	matrix metallopeptidase 9	Homo sapiens	129-134
27668533-4	2016	Based on the above, we investigated the interactions of pro-/active MMP-9 with the green tea catechins by computational methods.	Catechin	93-102	matrix metallopeptidase 9	Homo sapiens	68-73
27646578-0	2016	Effects of omega-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial.	Catechin	35-44	fatty acid synthase	Homo sapiens	48-67
27309037-2	2016	Previous studies in our laboratory reported that green tea extract (GTE) and its catechin, epigallocatechin gallate (EGCG) have immunoregulatory effects on IgE responses.	Catechin	81-89	immunoglobulin heavy constant epsilon	Homo sapiens	156-159
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	36-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	32-35
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	27-38	latexin	Homo sapiens	48-51
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	27-38	latexin	Homo sapiens	74-77
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	40-42	latexin	Homo sapiens	48-51
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	30-38	latexin	Homo sapiens	48-51
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	30-38	latexin	Homo sapiens	74-77
27735869-2	2016	In both water and ethanol, epicatechin (EC, 575 muM) and catechin (C, 575 muM) exhibited low photostabilities under 6 h UVB radiation with the generation of yellow photoproducts, while other catechins (epigallocatechin gallate, epigallocatechin, epicatechin gallate, gallocatechingallate, gallocatechin, catechin gallate) were relatively UVB-insensitive.	Catechin	41-42	latexin	Homo sapiens	48-51
28053292-8	2016	RESULTS: Daily intake of a standardized, decaffeinated, catechin mixture containing 200 mg EGCG BID taken with food for 1 year accumulated in plasma and was well tolerated and did not produce treatment related adverse effects in men with baseline HGPIN or ASAP.	Catechin	56-64	BH3 interacting domain death agonist	Homo sapiens	96-99
28053292-9	2016	CONCLUSION: The current data provides evidence of safety of decaffeinated, catechin mixture containing 200 mg EGCG BID to be further tested for prostate cancer prevention or other indications.	Catechin	75-83	BH3 interacting domain death agonist	Homo sapiens	115-118
27341781-0	2016	(-)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase.	Catechin	0-15	butyrylcholinesterase	Homo sapiens	87-108
30549596-5	2016	When the FRAP assay was applied, the order of increasing of antioxidant activity was quercetin &lt; gallic acid &lt; catechin.	Catechin	117-125	mechanistic target of rapamycin kinase	Homo sapiens	9-13
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	36-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	36-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	151-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	32-35
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	151-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
27531374-3	2016	Based on the inherent nature of tea catechin oxidation, fresh tea leaves are manufactured into diverse tea types by modulating the oxidation degree of catechins.	Catechin	151-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
26968772-0	2016	(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice.	Catechin	0-15	insulin	Homo sapiens	25-32
27006216-0	2016	Characterization of catechin-alpha-lactalbumin conjugates and the improvement in beta-carotene retention in an oil-in-water nanoemulsion.	Catechin	20-28	lactalbumin alpha	Homo sapiens	29-46
27006216-1	2016	The goal of this study was to prepare and characterize alpha-lactalbumin (ALA)-catechin conjugates as a novel emulsifier in improving the retention of beta-carotene (BC) in nanoemulsions via a free radical method.	Catechin	79-87	lactalbumin alpha	Homo sapiens	55-72
27006216-6	2016	BC retention stabilized with ALA-catechin conjugates was appreciably greater than ALA (control), which was attributed to the increase of ALA"s radicals-scavenging and free metal ion binding ability after grafting with catechin.	Catechin	33-41	5'-aminolevulinate synthase 1	Homo sapiens	137-142
27135790-0	2016	Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1beta responses.	Catechin	21-29	interleukin 15	Mus musculus	118-132
27356022-3	2016	SULT1A1, a major phase II metabolism SULT isoform, is found at a high concentration in liver and has recently been show to harbor two allosteric binding sites, each of which binds a separate and complex class of compounds: the catechins (naturally occurring polyphenols) and nonsteroidal anti-inflammatory drugs.	Catechin	227-236	sulfotransferase family 1A member 1	Homo sapiens	0-7
27356022-4	2016	Among catechins, epigallocatechin gallate (EGCG) displays high affinity and specificity for SULT1A1.	Catechin	6-15	sulfotransferase family 1A member 1	Homo sapiens	92-99
26576923-0	2016	Interaction of green tea catechins with renal organic cation transporter 2.	Catechin	25-34	solute carrier family 22 member 2	Homo sapiens	46-74
26576923-4	2016	Thus, this study assessed the potential of drug-green tea (GT) catechins and its derivatives interactions with rat Oct2 using renal cortical slices and S2 stably expressing rat Oct2 (S2rOct2).	Catechin	63-72	solute carrier family 22 member 2	Rattus norvegicus	115-119
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Catechin	91-99	thymoma viral proto-oncogene 1	Mus musculus	212-215
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Catechin	91-99	mechanistic target of rapamycin kinase	Mus musculus	220-224
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Catechin	91-99	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	250-254
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Catechin	91-99	mechanistic target of rapamycin kinase	Mus musculus	283-287
27301640-0	2016	Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2.	Catechin	0-11	nfe2 like bZIP transcription factor 2a	Danio rerio	141-145
27188290-11	2016	These data suggest that MERM rich in catechin can act as promising drug for AD treatment because of its antioxidant, anti-apoptotic and reducing Abeta oligomer activities.	Catechin	37-45	amyloid beta (A4) precursor protein	Mus musculus	145-150
27374085-6	2016	Functional studies showed that depletion of CTR1 expression reduced intracellular copper levels and led to a decrease in neuroblastoma cell sensitivity to Dextran-Catechin, implicating copper in the activity of this compound.	Catechin	163-171	solute carrier family 31 member 1	Homo sapiens	44-48
26968772-2	2016	Evidence from studies in humans and experimental animals suggest that consumption of the flavan-3-ol (-)-epicatechin (EC) and of EC-rich foods may improve insulin sensitivity.	Catechin	118-120	insulin	Homo sapiens	155-162
26968772-3	2016	To further understand the potential benefits of dietary EC consumption on insulin resistance, this study investigated the capacity of EC supplementation to prevent high fat diet (HFD)-induced insulin resistance in mice.	Catechin	134-136	insulin	Homo sapiens	192-199
26968772-9	2016	Thus, the above results suggest that consumption of EC-rich foods could constitute a dietary strategy to mitigate obesity-associated insulin resistance.	Catechin	52-54	insulin	Homo sapiens	133-140
26878122-11	2016	TNF-alpha, IL-6, NO, MPO and MDA were reduced in the mice administered epicatechin, whereas antioxidant enzymes showed increased activity in epicatechin-treated mice and cell line respectively.	Catechin	71-82	tumor necrosis factor	Mus musculus	0-9
27020533-8	2016	However, pre-treatment with catechin at a dose of 20 and 40 mg/kg significantly decreased LDH, LPO, B(a)P metabolizing enzymes and increased anti-oxidant armory as well as regulated apoptosis and inflammation in lungs.	Catechin	28-36	lactoperoxidase	Mus musculus	95-98
26878122-11	2016	TNF-alpha, IL-6, NO, MPO and MDA were reduced in the mice administered epicatechin, whereas antioxidant enzymes showed increased activity in epicatechin-treated mice and cell line respectively.	Catechin	71-82	interleukin 6	Mus musculus	11-15
26878122-11	2016	TNF-alpha, IL-6, NO, MPO and MDA were reduced in the mice administered epicatechin, whereas antioxidant enzymes showed increased activity in epicatechin-treated mice and cell line respectively.	Catechin	71-82	myeloperoxidase	Mus musculus	21-24
27112424-3	2016	Here, we show that these green tea catechin metabolites enhance CD4(+) T cell activity as well as natural killer (NK) cell activity.	Catechin	35-43	CD4 molecule	Homo sapiens	64-67
27144449-7	2016	Catechin up-regulated the Akt and mTOR phosphorylation and inhibited the hypoxia/reperfusion-induced autophagy in microglia.	Catechin	0-8	AKT serine/threonine kinase 1	Homo sapiens	26-29
27144449-7	2016	Catechin up-regulated the Akt and mTOR phosphorylation and inhibited the hypoxia/reperfusion-induced autophagy in microglia.	Catechin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	34-38
27144449-8	2016	These results suggest that hypoxia/reperfusion can evoke autophagy-activated microglia apoptosis/death via an ROS-regulated Akt/mTOR signaling pathway, which can be reversed by catechin.	Catechin	177-185	AKT serine/threonine kinase 1	Homo sapiens	124-127
27144449-8	2016	These results suggest that hypoxia/reperfusion can evoke autophagy-activated microglia apoptosis/death via an ROS-regulated Akt/mTOR signaling pathway, which can be reversed by catechin.	Catechin	177-185	mechanistic target of rapamycin kinase	Homo sapiens	128-132
27112424-0	2016	Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4(+) T Cell and Natural Killer Cell Activities.	Catechin	10-18	CD4 molecule	Homo sapiens	65-68
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	BCL2 apoptosis regulator	Homo sapiens	109-126
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	BCL2 apoptosis regulator	Homo sapiens	128-133
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	cytochrome c, somatic	Homo sapiens	162-174
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	caspase 3	Homo sapiens	204-213
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	caspase 8	Homo sapiens	215-224
27226712-9	2016	In addition, both catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression for activation of caspase-3, caspase-8, and caspase-9.	Catechin	18-26	caspase 9	Homo sapiens	230-239
26993496-0	2016	(-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase.	Catechin	0-15	nitric oxide synthase 3, endothelial cell	Mus musculus	92-125
26993496-2	2016	We investigated endothelial nitric oxide synthase involvement on (-)-epicatechin-induced increases in indicators associated with mitochondrial biogenesis in human coronary artery endothelial cells cultured in normal-glucose and high-glucose media, as well as to restore indicators of cardiac mitochondria from the effects of simulated diabetes.	Catechin	65-80	nitric oxide synthase 3, endothelial cell	Mus musculus	16-49
26993496-3	2016	Here, we demonstrate the role of endothelial nitric oxide synthase on (-)-epicatechin-induced increases in mitochondrial proteins, transcription factors and sirtuin 1 under normal-glucose conditions.	Catechin	70-85	nitric oxide synthase 3, endothelial cell	Mus musculus	33-66
26993496-3	2016	Here, we demonstrate the role of endothelial nitric oxide synthase on (-)-epicatechin-induced increases in mitochondrial proteins, transcription factors and sirtuin 1 under normal-glucose conditions.	Catechin	70-85	sirtuin 1	Mus musculus	157-166
26993496-4	2016	In simulated diabetes endothelial nitric oxide synthase function, mitochondrial function-associated and biogenesis-associated indicators were adversely impacted by high glucose, effects that were reverted by (-)-epicatechin.	Catechin	208-223	nitric oxide synthase 3, endothelial cell	Mus musculus	22-55
26993496-9	2016	Results suggest that endothelial nitric oxide synthase mediates (-)-epicatechin-induced increases of indicators associated with mitochondrial biogenesis in endothelial cells.	Catechin	64-79	nitric oxide synthase 3, endothelial cell	Mus musculus	21-54
26993496-10	2016	(-)-Epicatechin also counteracts the negative effects that high glucose or simulated type 2 diabetes has on endothelial nitric oxide synthase function.	Catechin	0-15	nitric oxide synthase 3, endothelial cell	Mus musculus	108-141
27279698-0	2016	Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.	Catechin	0-11	amyloid beta (A4) precursor protein	Mus musculus	79-104
27279698-0	2016	Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.	Catechin	0-11	presenilin 1	Mus musculus	105-117
27518169-0	2016	Inhibitory Effects of Eight Green Tea Catechins on Cytochrome P450 1A2, 2C9, 2D6, and 3A4 Activities.	Catechin	38-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	51-70
26972494-8	2016	Furthermore, both cyclosporine A (P-glycoprotein inhibitor) and MK-571 (MRP-2 inhibitor) significantly increased the cellular uptake and transport of (+)-catechin and puerarin.	Catechin	150-162	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	34-48
26972494-8	2016	Furthermore, both cyclosporine A (P-glycoprotein inhibitor) and MK-571 (MRP-2 inhibitor) significantly increased the cellular uptake and transport of (+)-catechin and puerarin.	Catechin	150-162	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-77
26972494-10	2016	The competitive efflux of (+)-catechin and puerarin by P-glycoprotein and MRP-2 might lead to this interaction during their absorption process in the small intestine.	Catechin	26-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	55-69
26972494-10	2016	The competitive efflux of (+)-catechin and puerarin by P-glycoprotein and MRP-2 might lead to this interaction during their absorption process in the small intestine.	Catechin	26-38	ATP binding cassette subfamily C member 2	Rattus norvegicus	74-79
28891624-11	2016	The proliferation and differentiation of hematopoietic progenitor cells in bone marrow were promoted, the apoptosis of bone marrow cells was significantly up-regulated and the expression of cleaved caspase-3 and Bax was significantly reduced in SSD and catechin group.	Catechin	253-261	BCL2-associated X protein	Mus musculus	212-215
27518169-4	2016	METHODS: The inhibitory effects of eight green tea catechins on drug metabolizing enzymes, cytochrome P450 (CYP) 1A2, 2C9, 2D6, and 3A4, were investigated in human liver microsomes.	Catechin	51-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-116
27518169-13	2016	The ingestion of beverages containing large amounts of green tea catechins together with drugs that are metabolized by CYP1A2, CYP2C9, and CYP3A4 should be avoided.	Catechin	65-74	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	127-133
25996649-2	2016	It was deemed necessary to determine whether major blueberry anthocyanins and catechins are ligands for the transcription factor peroxisome proliferator activated receptor alpha isoform (PPARalpha), and compare activation with known PPARalpha agonistic constituents, pterostilbene and resveratrol.	Catechin	78-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	129-177
25996649-2	2016	It was deemed necessary to determine whether major blueberry anthocyanins and catechins are ligands for the transcription factor peroxisome proliferator activated receptor alpha isoform (PPARalpha), and compare activation with known PPARalpha agonistic constituents, pterostilbene and resveratrol.	Catechin	78-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	187-196
26855049-3	2016	These conjugates not only stabilize plasmid DNA/polyethylenimine complexes via the strong DNA-binding affinity of green tea catechin, but also facilitate their transport into CD44-overexpressing cells via receptor-mediated endocytosis.	Catechin	124-132	CD44 molecule (Indian blood group)	Homo sapiens	175-179
26855049-8	2016	The present study suggests that the ternary complexes stabilized with hyaluronic acid-green tea catechin conjugates can be widely utilized for CD44-targeted delivery of nucleic acid-based therapeutics.	Catechin	96-104	CD44 molecule (Indian blood group)	Homo sapiens	143-147
26708302-10	2016	The results show that catechin derivatives can be probably used as lead compounds for the design of PKM2 enzyme activators and inhibitors.	Catechin	22-30	pyruvate kinase M1/2	Homo sapiens	100-104
26960205-0	2016	Antioxidant Activity and alpha-Glucosidase Inhibitory Activities of the Polycondensate of Catechin with Glyoxylic Acid.	Catechin	90-98	sucrase-isomaltase	Homo sapiens	25-42
26960205-5	2016	The enhanced CAA and alpha-glucosidase inhibitor activities of PCG could be due to catechin polymerization enhancing the binding capacity to the cellular membrane and enzymes.	Catechin	83-91	sucrase-isomaltase	Homo sapiens	21-38
26731576-0	2016	Mg(II)-Catechin nanoparticles delivering siRNA targeting EIF5A2 inhibit bladder cancer cell growth in vitro and in vivo.	Catechin	7-15	eukaryotic translation initiation factor 5A2	Mus musculus	57-63
26724590-0	2016	Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways.	Catechin	30-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
26724590-12	2016	Our results show that EC protects the TBI brain by activating the Nrf2 pathway, inhibiting heme oxygenase-1 protein expression, and reducing iron deposition.	Catechin	22-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
26724590-12	2016	Our results show that EC protects the TBI brain by activating the Nrf2 pathway, inhibiting heme oxygenase-1 protein expression, and reducing iron deposition.	Catechin	22-24	heme oxygenase 1	Mus musculus	91-107
26923508-10	2016	Plasma total and individual catechins were weakly to moderately associated with C-reactive protein, but not the case for urinary catechins.	Catechin	28-37	C-reactive protein	Homo sapiens	80-98
26059739-0	2015	Anti-nephrolithic potential of catechin in melamine-related urolithiasis via the inhibition of ROS, apoptosis, phospho-p38, and osteopontin in male Sprague-Dawley rats.	Catechin	31-39	mitogen activated protein kinase 14	Rattus norvegicus	119-122
26571386-2	2016	Circular dichroism and fluorescence spectra of (-)-epicatechin (EC) oligomers linked through C-4 to C-8 interflavan bonds showed that EC oligomers larger than dimers formed a stable secondary structure in water.	Catechin	47-62	complement C4A (Rodgers blood group)	Homo sapiens	93-96
26571386-2	2016	Circular dichroism and fluorescence spectra of (-)-epicatechin (EC) oligomers linked through C-4 to C-8 interflavan bonds showed that EC oligomers larger than dimers formed a stable secondary structure in water.	Catechin	47-62	homeobox C8	Homo sapiens	100-103
26571386-2	2016	Circular dichroism and fluorescence spectra of (-)-epicatechin (EC) oligomers linked through C-4 to C-8 interflavan bonds showed that EC oligomers larger than dimers formed a stable secondary structure in water.	Catechin	64-66	complement C4A (Rodgers blood group)	Homo sapiens	93-96
26571386-2	2016	Circular dichroism and fluorescence spectra of (-)-epicatechin (EC) oligomers linked through C-4 to C-8 interflavan bonds showed that EC oligomers larger than dimers formed a stable secondary structure in water.	Catechin	64-66	homeobox C8	Homo sapiens	100-103
27008260-6	2016	RESULTS: Epicatechin increased ALP activity, mineralized nodule formation, and the mRNA expression of dentin sialophosphoprotein (DSPP), a specific odontogenic-related marker.	Catechin	9-20	alkaline phosphatase, placental	Homo sapiens	31-34
27008260-6	2016	RESULTS: Epicatechin increased ALP activity, mineralized nodule formation, and the mRNA expression of dentin sialophosphoprotein (DSPP), a specific odontogenic-related marker.	Catechin	9-20	dentin sialophosphoprotein	Homo sapiens	102-128
27008260-6	2016	RESULTS: Epicatechin increased ALP activity, mineralized nodule formation, and the mRNA expression of dentin sialophosphoprotein (DSPP), a specific odontogenic-related marker.	Catechin	9-20	dentin sialophosphoprotein	Homo sapiens	130-134
27008260-8	2016	Epicatechin activated the extracellular signal-regulated kinase (ERK) and the treatment with an ERK inhibitor (U0126) blocked the expression of DSPP.	Catechin	0-11	mitogen-activated protein kinase 1	Homo sapiens	26-63
27008260-8	2016	Epicatechin activated the extracellular signal-regulated kinase (ERK) and the treatment with an ERK inhibitor (U0126) blocked the expression of DSPP.	Catechin	0-11	mitogen-activated protein kinase 1	Homo sapiens	65-68
27008260-8	2016	Epicatechin activated the extracellular signal-regulated kinase (ERK) and the treatment with an ERK inhibitor (U0126) blocked the expression of DSPP.	Catechin	0-11	dentin sialophosphoprotein	Homo sapiens	144-148
26955771-6	2016	We found that seven of them could bind to the protein NFkappaB (catechin, leucoanthocyanidin, niacin, phenylethylamine, theobromine, theophylline, and thiamin).	Catechin	64-72	nuclear factor kappa B subunit 1	Homo sapiens	54-62
26546527-12	2015	Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin.	Catechin	165-176	prostaglandin-endoperoxide synthase 2	Mus musculus	19-23
26278714-2	2016	We observed that the major catechin of green tea, (-)-Epigallocatechin-3-gallate (EGCG), induced retinoid X receptor-gamma (RXRgamma) expression in the SK-Ch-A1 cholangiocarcinoma cell line and in two colon carcinoma cell lines (LoVo and the derivative multi-drug resistant LoVoMDR).	Catechin	27-35	retinoid X receptor gamma	Homo sapiens	97-122
26278714-2	2016	We observed that the major catechin of green tea, (-)-Epigallocatechin-3-gallate (EGCG), induced retinoid X receptor-gamma (RXRgamma) expression in the SK-Ch-A1 cholangiocarcinoma cell line and in two colon carcinoma cell lines (LoVo and the derivative multi-drug resistant LoVoMDR).	Catechin	27-35	retinoid X receptor gamma	Homo sapiens	124-132
25416858-3	2016	Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice.	Catechin	8-16	synuclein, alpha	Mus musculus	114-118
25416858-3	2016	Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice.	Catechin	8-16	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	165-171
28044092-8	2016	The binding site is probably similar but not equivalent to that of green tea catechins, which, as previously demonstrated, can bind to PDIA3 and prevent its interaction with DNA.	Catechin	77-86	protein disulfide isomerase family A member 3	Homo sapiens	135-140
26234576-5	2015	To confirm the hypothesis that 3-nitrotyrosine generation is crucial for the impairment of plasmin activity, (-)-epicatechin, a polyphenolic antioxidant that selectively prevents tyrosine nitration, was used both for in vitro experiments as well as for in silico studies on ONOO(-), ONOOH and (-)-epicatechin binding and plasminogen nitration.	Catechin	109-124	plasminogen	Homo sapiens	91-98
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Catechin	47-55	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Catechin	47-55	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Catechin	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Catechin	47-55	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
26059739-0	2015	Anti-nephrolithic potential of catechin in melamine-related urolithiasis via the inhibition of ROS, apoptosis, phospho-p38, and osteopontin in male Sprague-Dawley rats.	Catechin	31-39	secreted phosphoprotein 1	Rattus norvegicus	128-139
26059739-13	2015	Our findings suggest that catechin exhibits anti-nephrolithic potential by chemically inhibiting the formation of crystals and by inhibiting reactive oxygen species, apoptosis, phospho-P38, and osteopontin signaling in rats.	Catechin	26-34	mitogen activated protein kinase 14	Rattus norvegicus	185-188
26059739-13	2015	Our findings suggest that catechin exhibits anti-nephrolithic potential by chemically inhibiting the formation of crystals and by inhibiting reactive oxygen species, apoptosis, phospho-P38, and osteopontin signaling in rats.	Catechin	26-34	secreted phosphoprotein 1	Rattus norvegicus	194-205
26303816-0	2015	The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER).	Catechin	15-30	G protein-coupled estrogen receptor 1	Bos taurus	64-99
26303816-0	2015	The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER).	Catechin	15-30	G protein-coupled estrogen receptor 1	Bos taurus	101-105
26323573-1	2015	Inhibitory activity of angiotensin I-converting enzyme (ACE) was examined with (-)-epigallocatechin gallate (EGCG) metabolites produced by intestinal bacteria, together with tea catechins.	Catechin	178-187	angiotensin I converting enzyme	Rattus norvegicus	23-54
26094613-8	2015	Epicatechin and lanceoloside A elicited significant inhibition of TNF-alpha release, indicating that they may account for the effect produced by O. semiserrata crude extract.	Catechin	0-11	tumor necrosis factor	Homo sapiens	66-75
26187476-0	2015	Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFkappaB p65 signal pathway.	Catechin	10-19	toll like receptor 4	Homo sapiens	127-132
26187476-0	2015	Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFkappaB p65 signal pathway.	Catechin	10-19	nuclear factor kappa B subunit 1	Homo sapiens	133-141
26187476-0	2015	Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFkappaB p65 signal pathway.	Catechin	10-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	142-145
26323573-1	2015	Inhibitory activity of angiotensin I-converting enzyme (ACE) was examined with (-)-epigallocatechin gallate (EGCG) metabolites produced by intestinal bacteria, together with tea catechins.	Catechin	178-187	angiotensin I converting enzyme	Rattus norvegicus	56-59
26323573-3	2015	Among the catechins, galloylated catechins exhibited stronger ACE inhibitory activity than nongalloylated catechins.	Catechin	10-19	angiotensin I converting enzyme	Rattus norvegicus	62-65
26323573-3	2015	Among the catechins, galloylated catechins exhibited stronger ACE inhibitory activity than nongalloylated catechins.	Catechin	33-42	angiotensin I converting enzyme	Rattus norvegicus	62-65
26323573-3	2015	Among the catechins, galloylated catechins exhibited stronger ACE inhibitory activity than nongalloylated catechins.	Catechin	33-42	angiotensin I converting enzyme	Rattus norvegicus	62-65
26393568-8	2015	By contrast, in guava leaf, catechin specifically contributed to GLUT5-mediated fructose uptake inhibition, and quercetin affected both GLUT5- and GLUT2-mediated fructose uptake inhibition, resulting in the higher contribution of GLUT5.	Catechin	28-36	solute carrier family 2 member 5	Homo sapiens	65-70
26393568-9	2015	These results suggest that demethoxycurcumin is an important contributor to GLUT2-mediated fructose uptake inhibition for turmeric extract, and catechin is the same to GLUT5-mediated fructose uptake inhibition for guava leaf extract.	Catechin	144-152	solute carrier family 2 member 5	Homo sapiens	168-173
28454959-5	2015	Of the phenolics tested, only gallic acid (GA) and galloyl moiety containing epicatechin, viz., epigallocatechin (EGC) and epigallocatechin gallate (EGCG) showed, comparative to others, higher PL inhibitions (IC50, 387.2, 237.3, and 391.2muM respectively).	Catechin	77-88	pancreatic lipase	Homo sapiens	193-195
26116387-5	2015	Preincubation of catalase with epigallocatechin gallate and quercetin before HOCl treatment enhances the degree of catalase inhibition, whereas catechin does not affect this process.	Catechin	39-47	catalase	Homo sapiens	17-25
26116387-5	2015	Preincubation of catalase with epigallocatechin gallate and quercetin before HOCl treatment enhances the degree of catalase inhibition, whereas catechin does not affect this process.	Catechin	39-47	catalase	Homo sapiens	115-123
26234731-0	2015	Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.	Catechin	22-30	NLR family pyrin domain containing 3	Homo sapiens	103-108
26233863-0	2015	Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.	Catechin	42-51	C-reactive protein	Homo sapiens	62-80
26234731-5	2015	Subcutaneous injection of gallic acid or catechin significantly reduced MSU-induced IL-1beta and IL-6 secretion in C57BL/6 mice.	Catechin	41-49	interleukin 1 beta	Mus musculus	84-92
26234731-5	2015	Subcutaneous injection of gallic acid or catechin significantly reduced MSU-induced IL-1beta and IL-6 secretion in C57BL/6 mice.	Catechin	41-49	interleukin 6	Mus musculus	97-101
26234731-6	2015	However, only catechin inhibited MSU-induced IL-1beta secretion and NLRP3 inflammasome activation in MSU-challenged THP-1 cells.	Catechin	14-22	interleukin 1 beta	Homo sapiens	45-53
26234731-8	2015	Catechin treatment also up-regulated Bcl-2 levels and restored MSU-induced mitochondrial transmembrane potential impairment.	Catechin	0-8	BCL2 apoptosis regulator	Homo sapiens	37-42
26234731-9	2015	These results indicate that the protective effects of catechin on MSU-induced IL-1beta secretion are associated with modulation of mitochondrial damage.	Catechin	54-62	interleukin 1 beta	Homo sapiens	78-86
26234731-10	2015	It also suggests that catechin has the potential to protect gout attack by modulation of NLRP3 inflammasome activation.	Catechin	22-30	NLR family pyrin domain containing 3	Homo sapiens	89-94
26246845-14	2015	Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model.	Catechin	127-136	diacylglycerol O-acyltransferase 1	Homo sapiens	219-224
25855392-3	2015	Recent reports indicated a reduction of left ventricular (LV) myocardial mass in WT-ATTR after consumption of epigallocatechin-3-gallate, the main catechin in green tea.	Catechin	118-126	transthyretin	Homo sapiens	84-88
26193264-6	2015	Maximum binding amounts of EC-C16 and C-C16 to the lipid bilayer clearly increased compared with that of (-)-EC and (+)-C, respectively.	Catechin	105-111	secretoglobin family 1A member 1	Homo sapiens	28-33
26028180-12	2015	From the present study, we can conclude that catechin exhibits potent anti-allergic activity by histidine decarboxylase enzyme inhibition and combination shown significant anti-allergic activity at reduced dose by both enzyme inhibition as well as inhibition of histamine receptors.	Catechin	45-53	histidine decarboxylase	Cavia porcellus	96-119
26193264-8	2015	In conclusion, the addition of an acyl group to the C-3 position of (-)-EC increases its affinity for the lipid bilayer membrane and promotes GLUT4 translocation through PI3K-dependent pathways in L6 myotubes.	Catechin	68-74	solute carrier family 2 member 4	Homo sapiens	142-147
25795629-11	2015	SFN and EGCG significantly, but catechin weakly, inhibited RANKL-mediated osteoclastogenesis in vitro.	Catechin	32-40	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	59-64
25774551-2	2015	We also found that a major functional catechin compound in green tea and cocoa, (-)-epicatechin, exerts antiadipogenic effects in the adipocytes through direct activation of TRPV3.	Catechin	38-46	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	174-179
25774551-2	2015	We also found that a major functional catechin compound in green tea and cocoa, (-)-epicatechin, exerts antiadipogenic effects in the adipocytes through direct activation of TRPV3.	Catechin	80-95	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	174-179
25774551-4	2015	TRPV3 activation by activators (-)-epicatechin and diphenylborinic anhydride was determined using live cell fluorescent Ca(2+) imaging and patch-clamp electrophysiology.	Catechin	31-46	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	0-5
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Catechin	149-157	sucrase-isomaltase	Homo sapiens	9-26
26044037-6	2015	Examination of the eight most abundant black bean seed coat, non-anthocyanin polyphenols via Caco-2 cell assays showed that four (catechin, 3,4-dihydroxybenzoic acid, kaempferol, and kaempferol 3-glucoside) clearly promoted iron uptake and four (myricetin, myricetin 3-glucoside, quercetin, and quercetin 3-glucoside) inhibited iron uptake.	Catechin	130-138	brain expressed associated with NEDD4 1	Homo sapiens	45-49
25974221-7	2015	Peroxiredoxins, catalase and peroxidases were associated with the oxidation of catechins.	Catechin	79-88	catalase	Homo sapiens	16-24
25891958-6	2015	tt13 phenocopies tt12, a mutant that is defective in vacuolar import of the PA precursor epicatechin.	Catechin	89-100	MATE efflux family protein	Arabidopsis thaliana	17-21
25849890-10	2015	Treatment of 3T3-L1 adipocytes with green tea catechins increased the level of glycerol and free fatty acids released into the media in the presence, but not absence, of norepinephrine, and increased the level of phosphorylated HSL in the cells.	Catechin	46-55	lipase E, hormone sensitive type	Homo sapiens	228-231
25849890-11	2015	The catechins also increased mRNA and protein levels of HSL and ATGL.	Catechin	4-13	lipase E, hormone sensitive type	Homo sapiens	56-59
25849890-11	2015	The catechins also increased mRNA and protein levels of HSL and ATGL.	Catechin	4-13	patatin like phospholipase domain containing 2	Homo sapiens	64-68
25849890-12	2015	PKA inhibitor (H89) attenuated the catechin-induced increase in glycerol release and HSL phosphorylation.	Catechin	35-43	lipase E, hormone sensitive type	Homo sapiens	85-88
25934864-11	2015	Epicatechin supplementation improved fasting plasma insulin (Delta insulin: -1.46 mU/L; 95% CI: -2.74, -0.18 mU/L; P = 0.03) and insulin resistance (Delta homeostasis model assessment of insulin resistance: -0.38; 95% CI: -0.74, -0.01; P = 0.04) and had no effect on fasting plasma glucose.	Catechin	0-11	insulin	Homo sapiens	52-59
25934864-11	2015	Epicatechin supplementation improved fasting plasma insulin (Delta insulin: -1.46 mU/L; 95% CI: -2.74, -0.18 mU/L; P = 0.03) and insulin resistance (Delta homeostasis model assessment of insulin resistance: -0.38; 95% CI: -0.74, -0.01; P = 0.04) and had no effect on fasting plasma glucose.	Catechin	0-11	insulin	Homo sapiens	67-74
25934864-11	2015	Epicatechin supplementation improved fasting plasma insulin (Delta insulin: -1.46 mU/L; 95% CI: -2.74, -0.18 mU/L; P = 0.03) and insulin resistance (Delta homeostasis model assessment of insulin resistance: -0.38; 95% CI: -0.74, -0.01; P = 0.04) and had no effect on fasting plasma glucose.	Catechin	0-11	insulin	Homo sapiens	67-74
25934864-11	2015	Epicatechin supplementation improved fasting plasma insulin (Delta insulin: -1.46 mU/L; 95% CI: -2.74, -0.18 mU/L; P = 0.03) and insulin resistance (Delta homeostasis model assessment of insulin resistance: -0.38; 95% CI: -0.74, -0.01; P = 0.04) and had no effect on fasting plasma glucose.	Catechin	0-11	insulin	Homo sapiens	67-74
25934864-14	2015	CONCLUSIONS: Our results suggest that epicatechin may in part contribute to the cardioprotective effects of cocoa and tea by improving insulin resistance.	Catechin	38-49	insulin	Homo sapiens	135-142
25582180-0	2015	Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers.	Catechin	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	42-61
25795020-4	2015	This study investigated the capacity of EC to inhibit TNFalpha-induced permeabilization of Caco-2 cell monolayers, characterizing the underlying mechanisms.	Catechin	40-42	tumor necrosis factor	Homo sapiens	54-62
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	tumor necrosis factor	Homo sapiens	13-21
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	NFKB inhibitor alpha	Homo sapiens	182-194
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	nuclear factor kappa B subunit 1	Homo sapiens	212-215
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	RELA proto-oncogene, NF-kB subunit	Homo sapiens	220-224
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	mitogen-activated protein kinase 3	Homo sapiens	283-289
25795020-8	2015	EC prevented TNFalpha-triggered Caco-2 monolayer permeabilization and acted inhibiting the associated: (i) NADPH oxidase (NOX)-mediated increased oxidant production, (ii) NF-kappaB (IkappaBalpha phosphorylation, p50 and RelA nuclear transport, and nuclear NF-kappaB-DNA binding) and ERK1/2 activation, (iii) increased myosin light kinase expression, and decreased TJ protein ZO-1 levels.	Catechin	0-2	myosin heavy chain 14	Homo sapiens	318-324
25778626-4	2015	The data indicate that the presence of thermally modified catechins in the diet more efficiently reduces the development of atherosclerosis in apoE knockout mice than the presence of native catechins.	Catechin	58-67	apolipoprotein E	Mus musculus	143-147
25582180-0	2015	Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers.	Catechin	0-9	aryl hydrocarbon receptor	Rattus norvegicus	74-99
27774417-0	2016	Green tea catechin inhibits the activity and neutrophil release of Matrix Metalloproteinase-9.	Catechin	10-18	matrix metallopeptidase 9	Homo sapiens	67-93
25771124-0	2015	A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis.	Catechin	2-10	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	116-123
25925963-2	2015	Orally supplemented catechin (OSC) was previously shown to increase mitochondrial heme and catalase levels in rat heart blood, however, its effect in the cytosol has not been elucidated.	Catechin	20-28	catalase	Rattus norvegicus	91-99
25914714-3	2015	Transcript levels of LAR1 and ANR2 genes were significantly correlated with the contents of catechin and epicatechin, respectively, which suggests their active roles in PA synthesis.	Catechin	92-100	leucoanthocyanidin reductase-like	Malus domestica	21-25
25914714-3	2015	Transcript levels of LAR1 and ANR2 genes were significantly correlated with the contents of catechin and epicatechin, respectively, which suggests their active roles in PA synthesis.	Catechin	105-116	leucoanthocyanidin reductase-like	Malus domestica	21-25
25914714-5	2015	This contradicts the previous finding that LAR1 gene is a strong candidate regulating the accumulation of metabolites such as epicatechin and PAs in apple.	Catechin	126-137	leucoanthocyanidin reductase-like	Malus domestica	43-47
25731855-4	2015	The efficiency of MPO to remove peroxynitrite was enhanced by L-tyrosine, nitrite and (-)-epicatechin, substances known to reduce Compound II with high reaction rate.	Catechin	86-101	myeloperoxidase	Homo sapiens	18-21
25442518-3	2015	Tensile strengths of SPI films with rutin and epicatechin were similar (35.1 MPa and 22.1 MPa, respectively) and significantly stronger than films without added phenolics (9.3 MPa).	Catechin	46-57	chromogranin A	Homo sapiens	21-24
25442518-5	2015	The addition of epicatechin was found to increase water vapour permeability significantly to 2.3 g mm/m(2)h kPa from 1.7 g mm/m(2)h kPa for SPI alone whereas rutin decreased water vapour permeability to 1.2 g mm/m(2)h kPa.	Catechin	16-27	chromogranin A	Homo sapiens	140-143
25442518-7	2015	Findings indicate that rutin and epicatechin may be used as a natural means for improving specific properties of SPI films.	Catechin	33-44	chromogranin A	Homo sapiens	113-116
25771124-0	2015	A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis.	Catechin	2-10	UBA_e1_C domain-containing protein	Caenorhabditis elegans	128-133
25586184-2	2015	Using recombinant human UGT isoforms, we show that glucuronic acid conjugation of the model substrate, (-)-epicatechin, is catalyzed mainly by UGT1A8 and UGT1A9.	Catechin	103-118	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	24-27
25586184-2	2015	Using recombinant human UGT isoforms, we show that glucuronic acid conjugation of the model substrate, (-)-epicatechin, is catalyzed mainly by UGT1A8 and UGT1A9.	Catechin	103-118	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	143-149
25586184-2	2015	Using recombinant human UGT isoforms, we show that glucuronic acid conjugation of the model substrate, (-)-epicatechin, is catalyzed mainly by UGT1A8 and UGT1A9.	Catechin	103-118	UDP glucuronosyltransferase 1 family, polypeptide A9	Mus musculus	154-160
25231457-0	2015	STAT5 reactivation by catechin modulates H2O 2-induced apoptosis through miR-182/FOXO1 pathway in SK-N-MC cells.	Catechin	22-30	signal transducer and activator of transcription 5A	Homo sapiens	0-5
25781705-5	2015	Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase.	Catechin	146-155	peroxiredoxin 2	Mus musculus	214-235
25781705-5	2015	Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase.	Catechin	146-155	hematopoietic prostaglandin D synthase	Mus musculus	237-262
25781705-5	2015	Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase.	Catechin	146-155	glutathione reductase	Mus musculus	264-285
25231457-0	2015	STAT5 reactivation by catechin modulates H2O 2-induced apoptosis through miR-182/FOXO1 pathway in SK-N-MC cells.	Catechin	22-30	microRNA 182	Homo sapiens	73-80
25231457-0	2015	STAT5 reactivation by catechin modulates H2O 2-induced apoptosis through miR-182/FOXO1 pathway in SK-N-MC cells.	Catechin	22-30	forkhead box O1	Homo sapiens	81-86
25231457-8	2015	To further confirm such events, we also demonstrated that Catechin, a well-known natural antioxidant, partially restored both the STAT5 activation and miR-182 expression resulting in cell survival.	Catechin	58-66	signal transducer and activator of transcription 5A	Homo sapiens	130-135
25231457-8	2015	To further confirm such events, we also demonstrated that Catechin, a well-known natural antioxidant, partially restored both the STAT5 activation and miR-182 expression resulting in cell survival.	Catechin	58-66	microRNA 182	Homo sapiens	151-158
24847951-0	2015	Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells.	Catechin	0-9	vascular endothelial growth factor A	Homo sapiens	18-52
24847951-1	2015	AIM: To investigate the effect of catechins on vascular endothelial growth factor (VEGF) production and cyclooxygenase-2 (COX-2) expression in human dental pulp cells (HDPC) stimulated with bacteria-derived factors or pro-inflammatory cytokines.	Catechin	34-43	decapping mRNA 2	Homo sapiens	168-172
25534770-5	2015	Early work demonstrated that catechins and nonsteroidal anti-inflammatory drugs inhibit SULT1A1 and suggested that the inhibition was not competitive versus substrates.	Catechin	29-38	sulfotransferase family 1A member 1	Homo sapiens	88-95
24847951-3	2015	HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha).	Catechin	22-31	decapping mRNA 2	Homo sapiens	0-4
24847951-8	2015	In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1beta.	Catechin	17-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-43
24847951-8	2015	In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1beta.	Catechin	17-26	interleukin 1 beta	Homo sapiens	74-82
24847951-0	2015	Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells.	Catechin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-84
25530268-0	2015	Epicatechin breaks preformed glycated serum albumin and reverses the retinal accumulation of advanced glycation end products.	Catechin	0-11	albumin	Rattus norvegicus	38-51
25498223-1	2015	Tea polyphenols (TPs) are bioactive flavanol-related catechins that have been shown to protect dopaminergic (DAergic) neurons against neurotoxin-induced injury in mouse Parkinson"s disease (PD) models.	Catechin	53-62	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
25530268-6	2015	The breakdown of the already formed AGEs was studied by treating glycated human serum albumin with (-)-epicatechin.	Catechin	99-114	albumin	Rattus norvegicus	80-93
25530268-11	2015	(-)-Epicatechin was able to break preformed glycated human serum albumin in vitro as well as reduce AGE accumulation in retinas in vivo in a dose dependent manner.	Catechin	0-15	albumin	Rattus norvegicus	59-72
25757931-0	2015	Structure-dependent inhibitory effects of green tea catechins on insulin secretion from pancreatic beta-cells.	Catechin	52-61	insulin	Homo sapiens	65-72
25474715-3	2015	The developed method showed high selectivity and specificity to directly screen alpha-glucosidase ligands from complex system by testing mixtures of positive ((+)-catechin) and negative (salicylic acid) controls in the optimized conditions.	Catechin	159-171	sucrase-isomaltase	Homo sapiens	80-97
25562843-0	2015	Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice.	Catechin	23-37	brain derived neurotrophic factor	Mus musculus	111-115
26227399-4	2015	Additionally, (+)-catechin suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, while augmenting IL-4.	Catechin	14-26	tumor necrosis factor	Mus musculus	56-83
26227399-4	2015	Additionally, (+)-catechin suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, while augmenting IL-4.	Catechin	14-26	tumor necrosis factor	Mus musculus	85-94
26227399-4	2015	Additionally, (+)-catechin suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, while augmenting IL-4.	Catechin	14-26	interleukin 6	Mus musculus	100-118
26227399-4	2015	Additionally, (+)-catechin suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, while augmenting IL-4.	Catechin	14-26	interleukin 4	Mus musculus	137-141
26227399-5	2015	(+)-catechin attenuated LPS-induced nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation via the inhibition of IkappaB-alpha phosphorylation.	Catechin	0-12	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	70-73
26227399-5	2015	(+)-catechin attenuated LPS-induced nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation via the inhibition of IkappaB-alpha phosphorylation.	Catechin	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	118-131
26227399-6	2015	Moreover, (+)-catechin blocked the activation of Akt and its inhibition was shown to play a crucial role in LPS-induced inflammation in BV-2 microglial cells.	Catechin	10-22	thymoma viral proto-oncogene 1	Mus musculus	49-52
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	mitogen-activated protein kinase 3	Mus musculus	103-109
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	mitogen-activated protein kinase 14	Mus musculus	116-154
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	mitogen-activated protein kinase 14	Mus musculus	156-164
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	mitogen-activated protein kinase 3	Mus musculus	193-199
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	mitogen-activated protein kinase 14	Mus musculus	212-220
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	nitric oxide synthase 2, inducible	Mus musculus	308-312
26227399-7	2015	(+)-catechin also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), and p-38 mitogen activated protein kinases (p38 MAPK) and specific inhibitors of ERK1/2 (UO126) and p38 MAPK (SB202190) subsequently down-regulated the expression of the proinflammatory mediators iNOS and COX-2.	Catechin	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	317-322
26227399-9	2015	Taken together, our data indicate that (+)-catechin exhibits anti-inflammatory effects in BV-2 cells by suppressing the production of proinflammatory mediators and mitigation of NF-kappaB through Akt, ERK, p38 MAPK, and AMPK pathways.	Catechin	39-51	thymoma viral proto-oncogene 1	Mus musculus	196-199
26227399-9	2015	Taken together, our data indicate that (+)-catechin exhibits anti-inflammatory effects in BV-2 cells by suppressing the production of proinflammatory mediators and mitigation of NF-kappaB through Akt, ERK, p38 MAPK, and AMPK pathways.	Catechin	39-51	mitogen-activated protein kinase 1	Mus musculus	201-204
26227399-9	2015	Taken together, our data indicate that (+)-catechin exhibits anti-inflammatory effects in BV-2 cells by suppressing the production of proinflammatory mediators and mitigation of NF-kappaB through Akt, ERK, p38 MAPK, and AMPK pathways.	Catechin	39-51	mitogen-activated protein kinase 14	Mus musculus	206-214
25694702-6	2015	Inhibitory effects of catechin standards EGCG and ECG on porcine pancreatic alpha-amylase activity were also observed.	Catechin	22-30	amylase alpha 2A	Homo sapiens	65-89
26227399-0	2015	(+)-Catechin Attenuates NF-kappaB Activation Through Regulation of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells.	Catechin	0-12	thymoma viral proto-oncogene 1	Mus musculus	67-70
26227399-3	2015	(+)-catechin attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and inhibited microglial NO and ROS production.	Catechin	0-12	nitric oxide synthase 2, inducible	Mus musculus	36-67
26227399-3	2015	(+)-catechin attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and inhibited microglial NO and ROS production.	Catechin	0-12	nitric oxide synthase 2, inducible	Mus musculus	69-73
26227399-3	2015	(+)-catechin attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and inhibited microglial NO and ROS production.	Catechin	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	79-95
26227399-3	2015	(+)-catechin attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and inhibited microglial NO and ROS production.	Catechin	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	97-102
25422365-3	2015	Here, we examined how mammalian transient receptor potential V1 (TRPV1) and TRPA1, which are nociceptive sensors, are activated by green tea catechins during the auto-oxidation process.	Catechin	141-150	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-63
25422365-3	2015	Here, we examined how mammalian transient receptor potential V1 (TRPV1) and TRPA1, which are nociceptive sensors, are activated by green tea catechins during the auto-oxidation process.	Catechin	141-150	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
25422365-3	2015	Here, we examined how mammalian transient receptor potential V1 (TRPV1) and TRPA1, which are nociceptive sensors, are activated by green tea catechins during the auto-oxidation process.	Catechin	141-150	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
26301040-10	2015	EC produced a slight increase ( 20%) in Cu/Zn-SOD activity in the control group.	Catechin	0-2	superoxide dismutase 1	Rattus norvegicus	40-49
25196850-0	2015	Identification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1.	Catechin	28-37	polo like kinase 1	Homo sapiens	85-103
25196850-4	2015	Here, we combined virtual and experimental screenings to identify green tea catechins as potent inhibitors of the PLK1 PBD.	Catechin	76-85	polo like kinase 1	Homo sapiens	114-118
25196850-7	2015	Cellular analysis further showed that catechins interfere with the proper subcellular localization of PLK1, lead to cell-cycle arrest in the S and G2M phases, and induce growth inhibition of several human cancer cell types, such as breast adenocarcinoma (MCF7), lung adenocarcinoma (A549), and cervical adenocarcinoma (HeLa).	Catechin	38-47	polo like kinase 1	Homo sapiens	102-106
26783468-0	2015	Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells.	Catechin	10-18	pyruvate carboxylase	Homo sapiens	37-40
26756426-6	2015	Catechin was effective in reducing the CdCl2-induced augmentation of phase I (P450 and CYPB5) as well as phase II (DT-diaphorase and glutathione-S-transferase) enzymes in testes.	Catechin	0-8	NAD(P)H dehydrogenase, quinone 1	Mus musculus	115-128
26756426-6	2015	Catechin was effective in reducing the CdCl2-induced augmentation of phase I (P450 and CYPB5) as well as phase II (DT-diaphorase and glutathione-S-transferase) enzymes in testes.	Catechin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	133-158
25910046-0	2015	Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry.	Catechin	0-8	neuraminidase 1	Homo sapiens	33-46
25316600-6	2015	Supporting this finding, we have shown reduced Abeta pathology and Abeta levels following short term, a 21-day oral delivery of (-)-epicatechin in 7-month-old TASTPM mice.	Catechin	128-143	amyloid beta (A4) precursor protein	Mus musculus	47-52
25316600-6	2015	Supporting this finding, we have shown reduced Abeta pathology and Abeta levels following short term, a 21-day oral delivery of (-)-epicatechin in 7-month-old TASTPM mice.	Catechin	128-143	amyloid beta (A4) precursor protein	Mus musculus	67-72
25361437-5	2015	These effects of (-)-epicatechin were associated with a higher endothelial NO synthase phosphorylation at an activation site and a reduced expression of the regulatory subunit, p47(phox), suggesting the involvement of posttranslational mechanisms in (-)-epicatechin action.	Catechin	17-32	NSFL1 cofactor	Rattus norvegicus	177-180
25316429-0	2015	Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury.	Catechin	48-56	C-C motif chemokine ligand 4	Homo sapiens	80-84
25316429-1	2015	In this study, the antioxidant activity and hepatoprotective effect of inulin and catechin grafted inulin (catechin-g-inulin) against carbon tetrachloride (CCl4)-induced acute liver injury were investigated.	Catechin	82-90	C-C motif chemokine ligand 4	Homo sapiens	156-160
25910046-3	2015	Together with computational molecular docking, all three catechins were found to bind to influenza neuraminidase in the vicinity of a structurally conserved cavity adjacent to residue 430 that has been suggested to be a secondary sialic acid binding site.	Catechin	57-66	neuraminidase 1	Homo sapiens	99-112
26301040-12	2015	The results show that EC is effective against MPP(+)-induced biochemical and behavioral damage, which is possible by an increase in Cu/Zn-SOD activity.	Catechin	22-24	superoxide dismutase 1	Rattus norvegicus	132-141
25464095-5	2014	Finally, eight catechins with COX-2 binding activity were screened in green tea, and their structures were characterized by ultraviolet (UV), accurate molecular weight, diagnostic fragment ions and nuclear magnetic resonance (NMR).	Catechin	15-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-35
25792496-5	2015	Green tea catechins and especially epigallocatechin gallate modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1).	Catechin	10-19	DNA methyltransferase 1	Homo sapiens	114-137
25792496-5	2015	Green tea catechins and especially epigallocatechin gallate modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1).	Catechin	10-19	DNA methyltransferase 1	Homo sapiens	139-144
25316200-7	2014	Although partial inhibition of human hepatic and intestinal microsomal CYP2C8, CYP2B6, CYP3A4, CYP2D6 and CYP2C19 by GTE catechins was observed in vitro, a clinical study of drug bioavailability attributed a small risk of increased plasma drug levels only for substrates metabolized by CYP3A4, lacking clinical relevance.	Catechin	121-130	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	71-77
25316200-7	2014	Although partial inhibition of human hepatic and intestinal microsomal CYP2C8, CYP2B6, CYP3A4, CYP2D6 and CYP2C19 by GTE catechins was observed in vitro, a clinical study of drug bioavailability attributed a small risk of increased plasma drug levels only for substrates metabolized by CYP3A4, lacking clinical relevance.	Catechin	121-130	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-85
25316200-7	2014	Although partial inhibition of human hepatic and intestinal microsomal CYP2C8, CYP2B6, CYP3A4, CYP2D6 and CYP2C19 by GTE catechins was observed in vitro, a clinical study of drug bioavailability attributed a small risk of increased plasma drug levels only for substrates metabolized by CYP3A4, lacking clinical relevance.	Catechin	121-130	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93
25284161-0	2014	(-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic delta-sarcoglycan null mouse striated muscle.	Catechin	0-15	sarcoglycan, delta (dystrophin-associated glycoprotein)	Mus musculus	109-126
25284161-6	2014	In this study, we explored the capacity of the cacao flavonoid (-)-epicatechin (Epi) to mitigate OS by acting as a positive regulator of mitochondrial structure/function endpoints and redox balance control systems in skeletal and cardiac muscles of dystrophic, delta-sarcoglycan (delta-SG) null mice.	Catechin	63-78	sarcoglycan, delta (dystrophin-associated glycoprotein)	Mus musculus	261-278
25284161-6	2014	In this study, we explored the capacity of the cacao flavonoid (-)-epicatechin (Epi) to mitigate OS by acting as a positive regulator of mitochondrial structure/function endpoints and redox balance control systems in skeletal and cardiac muscles of dystrophic, delta-sarcoglycan (delta-SG) null mice.	Catechin	63-78	sarcoglycan, delta (dystrophin-associated glycoprotein)	Mus musculus	280-288
25316200-7	2014	Although partial inhibition of human hepatic and intestinal microsomal CYP2C8, CYP2B6, CYP3A4, CYP2D6 and CYP2C19 by GTE catechins was observed in vitro, a clinical study of drug bioavailability attributed a small risk of increased plasma drug levels only for substrates metabolized by CYP3A4, lacking clinical relevance.	Catechin	121-130	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	95-101
25316200-7	2014	Although partial inhibition of human hepatic and intestinal microsomal CYP2C8, CYP2B6, CYP3A4, CYP2D6 and CYP2C19 by GTE catechins was observed in vitro, a clinical study of drug bioavailability attributed a small risk of increased plasma drug levels only for substrates metabolized by CYP3A4, lacking clinical relevance.	Catechin	121-130	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	106-113
25195023-10	2014	The current sweeping-MEKC achieved sensitivity enhancement factor (SEF) up to 183-fold of analytes concentrations compared to other hitherto published CE reports that is suitable to find out the trace amounts of catechins in plasma.	Catechin	212-221	transcription factor CP2	Homo sapiens	35-65
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	catalase	Mus musculus	182-190
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	catalase	Mus musculus	192-195
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	hematopoietic prostaglandin D synthase	Mus musculus	198-223
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	hematopoietic prostaglandin D synthase	Mus musculus	225-228
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	glutathione reductase	Mus musculus	231-252
25310126-2	2014	The biological evaluation outcome indicated that the (+)-catechin emulsified gel increased the activity of oxidative stress biomarkers glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), whereas it decreased the level of malondialdehyde (MDA).	Catechin	53-65	glutathione reductase	Mus musculus	254-256
25294295-0	2014	Evaluation of non-covalent interactions between serum albumin and green tea catechins by affinity capillary electrophoresis.	Catechin	76-85	albumin	Homo sapiens	48-61
25325059-8	2014	Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits atherogenesis in rodents, likely due to, in large part, NF-kappaB antagonism.	Catechin	123-132	heme oxygenase 1	Homo sapiens	13-29
25230741-0	2014	Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women.	Catechin	19-27	thioredoxin	Homo sapiens	100-111
25195023-10	2014	The current sweeping-MEKC achieved sensitivity enhancement factor (SEF) up to 183-fold of analytes concentrations compared to other hitherto published CE reports that is suitable to find out the trace amounts of catechins in plasma.	Catechin	212-221	transcription factor CP2	Homo sapiens	67-70
25088664-7	2014	We have found that the main compounds absorbed by intestinal CaCo-2 cells after an acute treatment with GSPE are catechin, epicatechin, B2 dimer and gallic acid, and that they inhibit the DPP4 activity in endothelial HUVEC cells in an additive way.	Catechin	123-134	dipeptidyl peptidase 4	Homo sapiens	188-192
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	Catechin	28-37	membrane associated ring-CH-type finger 8	Homo sapiens	108-111
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	Catechin	28-37	KRAS proto-oncogene, GTPase	Homo sapiens	132-137
25017900-6	2014	A mixture of green tea catechins (GTCs) significantly inhibited viability, migration, expression of MMP-2 and -9, ALDH1 activity, colony and spheroid formation and induced apoptosis, but the combination of GTCs with sulforaphane or quercetin was superior.	Catechin	23-32	matrix metallopeptidase 2	Homo sapiens	100-112
25017900-6	2014	A mixture of green tea catechins (GTCs) significantly inhibited viability, migration, expression of MMP-2 and -9, ALDH1 activity, colony and spheroid formation and induced apoptosis, but the combination of GTCs with sulforaphane or quercetin was superior.	Catechin	23-32	aldehyde dehydrogenase 1 family member A1	Homo sapiens	114-119
25270015-0	2014	Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARalpha oncoprotein degradation.	Catechin	0-9	promyelocytic leukemia	Mus musculus	76-79
25270015-0	2014	Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARalpha oncoprotein degradation.	Catechin	0-9	retinoic acid receptor, alpha	Mus musculus	80-88
25270015-9	2014	Moreover, Catechins induced the degradation of PML-RARalpha oncoprotein.	Catechin	10-19	promyelocytic leukemia	Mus musculus	47-50
25270015-9	2014	Moreover, Catechins induced the degradation of PML-RARalpha oncoprotein.	Catechin	10-19	retinoic acid receptor, alpha	Mus musculus	51-59
25270015-12	2014	CONCLUSIONS: Catechins might be a potential candidate for APL treatment by activating intrinsic apoptotic pathway and targeting PML-RARalpha oncoprotein.	Catechin	13-22	promyelocytic leukemia	Mus musculus	128-131
25270015-12	2014	CONCLUSIONS: Catechins might be a potential candidate for APL treatment by activating intrinsic apoptotic pathway and targeting PML-RARalpha oncoprotein.	Catechin	13-22	retinoic acid receptor, alpha	Mus musculus	132-140
25111890-0	2014	Replica exchange Monte Carlo simulation of human serum albumin-catechin complexes.	Catechin	63-71	albumin	Homo sapiens	49-62
25111890-1	2014	Replica exchange Monte Carlo simulation equipped with an orientation-enhanced hydrophobic interaction was utilized to study the impacts of molar ratio and ionic strength on the complex formation of human serum albumin (HSA) and catechin.	Catechin	228-236	albumin	Homo sapiens	204-217
24916123-0	2014	Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins.	Catechin	108-120	macrophage migration inhibitory factor	Homo sapiens	21-59
24916123-0	2014	Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins.	Catechin	108-120	macrophage migration inhibitory factor	Homo sapiens	61-64
24916123-0	2014	Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins.	Catechin	108-120	myeloperoxidase	Homo sapiens	69-84
24916123-4	2014	The objective of the present study was to determine if MIF was susceptible to modification by epicatechins, a group of dietary flavonoids with known anti-inflammatory properties.	Catechin	94-106	macrophage migration inhibitory factor	Homo sapiens	55-58
24916123-5	2014	Epicatechins are substrates for peroxidases including neutrophil-derived MPO (myeloperoxidase).	Catechin	0-12	myeloperoxidase	Homo sapiens	73-76
24916123-5	2014	Epicatechins are substrates for peroxidases including neutrophil-derived MPO (myeloperoxidase).	Catechin	0-12	myeloperoxidase	Homo sapiens	78-93
24916123-6	2014	In the present study we show that oxidation of the catechol moiety of epicatechins to an omicron-quinone by MPO generates potent MIF inhibitors.	Catechin	70-82	myeloperoxidase	Homo sapiens	108-111
24916123-6	2014	In the present study we show that oxidation of the catechol moiety of epicatechins to an omicron-quinone by MPO generates potent MIF inhibitors.	Catechin	70-82	macrophage migration inhibitory factor	Homo sapiens	129-132
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	48-59	macrophage migration inhibitory factor	Homo sapiens	28-31
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	48-59	myeloperoxidase	Homo sapiens	39-42
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	48-59	macrophage migration inhibitory factor	Homo sapiens	127-130
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	119-127	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	142-150	sucrase-isomaltase	Homo sapiens	57-74
24995632-7	2014	The antidiabetic activity in vitro assays shows that the alpha-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan&gt;catechin&gt;acarbose&gt;chitosan, and the alpha-amylase inhibitory effect decreases in the order of acarbose&gt;catechin-g-chitosan&gt;catechin&gt;chitosan.	Catechin	142-150	sucrase-isomaltase	Homo sapiens	57-74
25179684-0	2014	Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with Abeta1-42, PrP106-126, and ataxin-3 oligomers.	Catechin	103-112	ataxin 3	Homo sapiens	160-168
25179684-1	2014	By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the interaction of green tea catechins with Abeta1-42, PrP106-126, and ataxin-3 oligomers.	Catechin	176-185	ataxin 3	Homo sapiens	218-226
25238062-1	2014	INTRODUCTION: Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins.	Catechin	153-162	catechol-O-methyltransferase	Homo sapiens	114-143
25238062-1	2014	INTRODUCTION: Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins.	Catechin	153-162	catechol-O-methyltransferase	Homo sapiens	144-148
25238062-8	2014	CONCLUSION: Subjects carrying the COMT(H) genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMT(L) genotype carriers reacted similarly to GT and PL ingestion.	Catechin	126-135	catechol-O-methyltransferase	Homo sapiens	34-38
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	48-59	myeloperoxidase	Homo sapiens	162-165
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	111-122	macrophage migration inhibitory factor	Homo sapiens	28-31
24916123-7	2014	Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates.	Catechin	111-122	myeloperoxidase	Homo sapiens	39-42
24916123-8	2014	We have characterized the modification introduced by oxidized (-)-epicatechin on MIF by LC-MS (liquid chromatography MS) and found it to occur at the N-terminal proline.	Catechin	62-77	macrophage migration inhibitory factor	Homo sapiens	81-84
24916123-9	2014	We propose that MIF inhibition by oxidized epicatechins contributes to the anti-inflammatory activity of these compounds.	Catechin	43-55	macrophage migration inhibitory factor	Homo sapiens	16-19
26785071-0	2014	Kinetics and Mechanistic Studies on the Reaction between Cytochrome c and Tea Catechins.	Catechin	78-87	cytochrome c, somatic	Homo sapiens	57-69
26785071-4	2014	It was discovered that tea catechins can react with cytochrome c.	Catechin	27-36	cytochrome c, somatic	Homo sapiens	52-64
26785071-5	2014	When oxidized cytochrome c was mixed with catechins commonly found in green tea under non-steady-state conditions, a reduction of cytochrome c was observed.	Catechin	42-51	cytochrome c, somatic	Homo sapiens	14-26
26785071-5	2014	When oxidized cytochrome c was mixed with catechins commonly found in green tea under non-steady-state conditions, a reduction of cytochrome c was observed.	Catechin	42-51	cytochrome c, somatic	Homo sapiens	130-142
23896702-0	2014	Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2).	Catechin	10-18	catalase	Homo sapiens	58-66
25229015-9	2014	These results demonstrated that oxidative stress was involved in Abeta-induced neuronal death, and antioxidative flavonoid compounds, especially epicatechin, EGCG, luteolin, and myricetin, could inhibit neuronal death.	Catechin	145-156	amyloid beta (A4) precursor protein	Mus musculus	65-70
23896702-0	2014	Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2).	Catechin	10-18	transient receptor potential cation channel subfamily M member 2	Homo sapiens	87-128
23896702-0	2014	Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2).	Catechin	10-18	transient receptor potential cation channel subfamily M member 2	Homo sapiens	130-135
23896702-2	2014	In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.	Catechin	43-52	catalase	Homo sapiens	92-100
23896702-2	2014	In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.	Catechin	43-52	transient receptor potential cation channel subfamily M member 2	Homo sapiens	121-162
24944597-0	2014	Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression.	Catechin	10-18	BCL2 like 1	Homo sapiens	138-144
25025898-0	2014	Inhibition of catalase by tea catechins in free and cellular state: a biophysical approach.	Catechin	30-39	catalase	Homo sapiens	14-22
25025898-2	2014	In the present study, binding and inhibition of catalase activity by catechins with respect to their structure-affinity relationship has been elucidated.	Catechin	69-78	catalase	Homo sapiens	48-56
25025898-4	2014	Thermodynamic parameters evidence exothermic and spontaneous interaction between catechins and catalase.	Catechin	81-90	catalase	Homo sapiens	95-103
25025898-10	2014	These results decipher the molecular mechanism by which tea catechins interact with catalase and highlight the potential of gallated catechin like EGCG as an anticancer drug.	Catechin	60-69	catalase	Homo sapiens	84-92
25025898-10	2014	These results decipher the molecular mechanism by which tea catechins interact with catalase and highlight the potential of gallated catechin like EGCG as an anticancer drug.	Catechin	60-68	catalase	Homo sapiens	84-92
24721612-6	2014	The inhibition of MMP-9 and CT-B by 0.65, 0.065 and 0.0065% of each catechin was determined using fluorimetric proteolytic assay kits.	Catechin	68-76	matrix metallopeptidase 9	Homo sapiens	18-23
24721612-6	2014	The inhibition of MMP-9 and CT-B by 0.65, 0.065 and 0.0065% of each catechin was determined using fluorimetric proteolytic assay kits.	Catechin	68-76	phosphate cytidylyltransferase 1B, choline	Homo sapiens	28-32
24721612-9	2014	Overall, the 3-O-galloylated monomeric catechins are clearly more potent than their non-galloylated analogues in improving dentin mechanical properties, stabilizing collagen against proteolytic degradation, and inhibiting the activity of MMPs and CTs.	Catechin	39-48	matrix metallopeptidase 9	Homo sapiens	238-242
23789886-10	2014	(-)-epicatechin from W. indica dose dependently inhibited PLA2 (IC50 = 154.7 mum) and 5-LOX (IC50 = 15.8 mum).	Catechin	0-15	lysyl oxidase	Rattus norvegicus	88-91
23883519-2	2014	However, previous studies have shown that a group of tea flavonoids, the catechins, are brain permeable and neuroprotective.	Catechin	73-82	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
24810472-0	2014	Insulin polymers in the plasma of obese subjects are associated with elevated levels of carbonyl groups and are decreased by (-)-epicatechin.	Catechin	125-140	insulin	Homo sapiens	0-7
24810472-10	2014	The antioxidant (-)-epicatechin decreased the formation of the insulin polymer, indicating that the prevention of oxidative damage can inhibit insulin polymerization.	Catechin	16-31	insulin	Homo sapiens	63-70
24810472-10	2014	The antioxidant (-)-epicatechin decreased the formation of the insulin polymer, indicating that the prevention of oxidative damage can inhibit insulin polymerization.	Catechin	16-31	insulin	Homo sapiens	143-150
24810472-12	2014	This study also demonstrates that the antioxidant (-)-epicatechin inhibits insulin polymerization.	Catechin	50-65	insulin	Homo sapiens	75-82
24687133-10	2014	Reduced glutathione prevented peroxynitrite-induced FeOxI drop, tyrosine nitration, and cysteine oxidation; flavonoid(-)-epicatechin, which prevented ceruloplasmin tyrosine nitration but not cysteine oxidation, partially impeded peroxynitrite-induced FeOxI drop.	Catechin	117-132	ceruloplasmin	Homo sapiens	150-163
24876661-4	2014	For the B-ring analogues, the anti- (catechin) stereochemistry was converted to the syn- (epicatechin) stereochemistry by a known oxidation/reduction protocol.	Catechin	37-45	synemin	Homo sapiens	84-87
24876661-4	2014	For the B-ring analogues, the anti- (catechin) stereochemistry was converted to the syn- (epicatechin) stereochemistry by a known oxidation/reduction protocol.	Catechin	90-101	synemin	Homo sapiens	84-87
24712558-7	2014	Pretreatment of the fibroblasts with (+)-catechin inhibited hydrogen peroxide-induced apoptosis and reduced phosphorylation of JNK and p38 and activation of caspase-3.	Catechin	37-49	mitogen-activated protein kinase 8	Homo sapiens	127-130
24360431-6	2014	In the infusion brewed with tap water, catechins appeared to be epimerisation from the epistructure to the nonepistructure.	Catechin	39-48	nuclear RNA export factor 1	Homo sapiens	28-31
24847308-0	2014	Effects of (-)Epicatechin on the Pathology of APP/PS1 Transgenic Mice.	Catechin	11-25	presenilin 1	Mus musculus	50-53
24847308-7	2014	(-)Epicatechin significantly reduced total Abeta in brain and serum by 39 and 40%, respectively, compared with control diet.	Catechin	3-14	amyloid beta (A4) precursor protein	Mus musculus	43-48
24712558-7	2014	Pretreatment of the fibroblasts with (+)-catechin inhibited hydrogen peroxide-induced apoptosis and reduced phosphorylation of JNK and p38 and activation of caspase-3.	Catechin	37-49	mitogen-activated protein kinase 14	Homo sapiens	135-138
24712558-7	2014	Pretreatment of the fibroblasts with (+)-catechin inhibited hydrogen peroxide-induced apoptosis and reduced phosphorylation of JNK and p38 and activation of caspase-3.	Catechin	37-49	caspase 3	Homo sapiens	157-166
24712558-8	2014	CONCLUSION: (+)-Catechin protects against oxidative stress-induced cell death in fibroblasts, possibly by inhibiting phosphorylation of p38 and JNK.	Catechin	12-24	mitogen-activated protein kinase 14	Homo sapiens	136-139
24712558-8	2014	CONCLUSION: (+)-Catechin protects against oxidative stress-induced cell death in fibroblasts, possibly by inhibiting phosphorylation of p38 and JNK.	Catechin	12-24	mitogen-activated protein kinase 8	Homo sapiens	144-147
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	115-123	sucrase-isomaltase	Homo sapiens	51-68
24741667-0	2014	(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways.	Catechin	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
24741667-2	2014	(-)-Epicatechin (EC), a brain-permeable flavanol that modulates redox/oxidative stress via the NF-E2-related factor (Nrf) 2 pathway, has been shown to be beneficial for vascular and cognitive function in humans.	Catechin	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	95-123
24741667-2	2014	(-)-Epicatechin (EC), a brain-permeable flavanol that modulates redox/oxidative stress via the NF-E2-related factor (Nrf) 2 pathway, has been shown to be beneficial for vascular and cognitive function in humans.	Catechin	17-19	NFE2 like bZIP transcription factor 2	Homo sapiens	95-123
24911082-11	2014	TGF-beta 1 immunostaining was significantly lower in the catechin-treated and perindopril-treated groups than in the untreated diabetic group (p &lt; 0.001).	Catechin	57-65	transforming growth factor, beta 1	Rattus norvegicus	0-10
24491460-0	2014	Potential alpha-glucosidase inhibitors from thermal transformation of (+)-catechin.	Catechin	70-82	sucrase-isomaltase	Homo sapiens	10-27
24491460-3	2014	The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against alpha-glucosidase, with IC50 values of 0.16+-0.2 and 0.14+-0.2muM, respectively, when compared to parent (+)-catechin.	Catechin	4-12	sucrase-isomaltase	Homo sapiens	91-108
24491460-3	2014	The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against alpha-glucosidase, with IC50 values of 0.16+-0.2 and 0.14+-0.2muM, respectively, when compared to parent (+)-catechin.	Catechin	196-208	sucrase-isomaltase	Homo sapiens	91-108
24370660-7	2014	First, the dimeric molecules, such as theaflavin and procyanidin B-2, generally displayed more potent antiviral activity against both influenza A and B viruses than the catechin monomers.	Catechin	169-177	immunoglobulin kappa variable 5-2	Homo sapiens	65-68
24529136-0	2014	Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFkappaB in vivo.	Catechin	0-11	C-reactive protein	Homo sapiens	98-101
24529136-0	2014	Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFkappaB in vivo.	Catechin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	106-114
24529136-7	2014	Epicatechin mitigated diet-induced increases in plasma SAA (in ApoE*3-Leiden mice) and plasma human-CRP (in human-CRP transgenic mice).	Catechin	0-11	serum amyloid A cluster	Mus musculus	55-58
24529136-7	2014	Epicatechin mitigated diet-induced increases in plasma SAA (in ApoE*3-Leiden mice) and plasma human-CRP (in human-CRP transgenic mice).	Catechin	0-11	C-reactive protein	Homo sapiens	100-103
24529136-7	2014	Epicatechin mitigated diet-induced increases in plasma SAA (in ApoE*3-Leiden mice) and plasma human-CRP (in human-CRP transgenic mice).	Catechin	0-11	C-reactive protein	Homo sapiens	114-117
24529136-8	2014	Microarray analysis of aortic gene expression revealed an attenuating effect of epicatechin on several diet-induced pro-atherogenic inflammatory processes in the aorta (e.g. chemotaxis of cells, matrix remodelling), regulated by NFkappaB.	Catechin	80-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	229-237
24529136-9	2014	These findings were confirmed immunohistochemically by reduced lesional neutrophil content in HCE, and by inhibition of diet-induced NFkappaB activity in epicatechin-treated NFkappaB-luciferase reporter mice.	Catechin	154-165	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-141
24529136-9	2014	These findings were confirmed immunohistochemically by reduced lesional neutrophil content in HCE, and by inhibition of diet-induced NFkappaB activity in epicatechin-treated NFkappaB-luciferase reporter mice.	Catechin	154-165	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	174-182
24529136-11	2014	The observed reduction of circulating inflammatory risk factors by epicatechin (e.g. SAA, human-CRP), as well as its local anti-inflammatory activity in the vessel wall, provide a rationale for epicatechin"s anti-atherogenic effects.	Catechin	194-205	serum amyloid A1 cluster	Homo sapiens	85-88
24529136-11	2014	The observed reduction of circulating inflammatory risk factors by epicatechin (e.g. SAA, human-CRP), as well as its local anti-inflammatory activity in the vessel wall, provide a rationale for epicatechin"s anti-atherogenic effects.	Catechin	194-205	C-reactive protein	Homo sapiens	96-99
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	136-144	sucrase-isomaltase	Homo sapiens	51-68
24315946-10	2014	Moreover, in vitro anti-diabetic assays showed the alpha-glucosidase inhibitory activity decreased in the order of catechin-g-inulin&gt;catechin&gt;acarbose&gt;inulin, and alpha-amylase inhibitory activity decreased in the order of catechin-g-inulin&gt;acarbose&gt;catechin&gt;inulin.	Catechin	136-144	sucrase-isomaltase	Homo sapiens	51-68
24508265-0	2014	Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide.	Catechin	10-19	brain-derived neurotrophic factor	Rattus norvegicus	58-91
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Catechin	214-225	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	42-46
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Catechin	214-225	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	97-101
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Catechin	214-225	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	102-107
24255956-9	2014	Furthermore, Janus kinase 2 (JAK2) kinase assay data suggest that the contemporary presence in vitro of STAT1 and catechins inhibits JAK2-elicited STAT1 phosphorylation.	Catechin	114-123	Janus kinase 2	Homo sapiens	29-33
24516636-7	2014	(-)-Epicatechin sensitized Panc-1, U87, and MIA PaCa-2 cells with an average radiation enhancement factor (REF) of 1.7, 1.5, and 1.2, respectively.	Catechin	0-15	small nucleolar RNA, C/D box 87	Homo sapiens	35-38
24516636-9	2014	(-)-Epicatechin enhanced Chk2 phosphorylation and p21 induction when combined with radiation in cancer, but not normal, cells.	Catechin	0-15	checkpoint kinase 2	Homo sapiens	25-29
24516636-9	2014	(-)-Epicatechin enhanced Chk2 phosphorylation and p21 induction when combined with radiation in cancer, but not normal, cells.	Catechin	0-15	H3 histone pseudogene 16	Homo sapiens	50-53
24255956-0	2014	Direct interaction of natural and synthetic catechins with signal transducer activator of transcription 1 affects both its phosphorylation and activity.	Catechin	44-53	signal transducer and activator of transcription 1	Homo sapiens	59-105
24329914-2	2014	We reported previously that epigallocatechin-3-gallate (EGCG), the most abundant green tea catechin, normalizes the PCNA level.	Catechin	36-44	proliferating cell nuclear antigen	Mus musculus	116-120
24255956-5	2014	Our results demonstrate a direct interaction between STAT1 protein and catechins displaying anti-STAT1 activity.	Catechin	71-80	signal transducer and activator of transcription 1	Homo sapiens	53-58
24255956-5	2014	Our results demonstrate a direct interaction between STAT1 protein and catechins displaying anti-STAT1 activity.	Catechin	71-80	signal transducer and activator of transcription 1	Homo sapiens	97-102
24255956-7	2014	Based on docking data, site-directed mutagenesis was performed, and interaction of the most active catechins with STAT1 was studied with SPR to test whether Gln518 on site a and His568 on site b could be important for the catechin-STAT1 interaction.	Catechin	99-108	signal transducer and activator of transcription 1	Homo sapiens	114-119
24255956-7	2014	Based on docking data, site-directed mutagenesis was performed, and interaction of the most active catechins with STAT1 was studied with SPR to test whether Gln518 on site a and His568 on site b could be important for the catechin-STAT1 interaction.	Catechin	99-108	signal transducer and activator of transcription 1	Homo sapiens	231-236
24255956-7	2014	Based on docking data, site-directed mutagenesis was performed, and interaction of the most active catechins with STAT1 was studied with SPR to test whether Gln518 on site a and His568 on site b could be important for the catechin-STAT1 interaction.	Catechin	99-107	signal transducer and activator of transcription 1	Homo sapiens	114-119
24255956-7	2014	Based on docking data, site-directed mutagenesis was performed, and interaction of the most active catechins with STAT1 was studied with SPR to test whether Gln518 on site a and His568 on site b could be important for the catechin-STAT1 interaction.	Catechin	99-107	signal transducer and activator of transcription 1	Homo sapiens	231-236
24255956-8	2014	Data indicate that site b has higher affinity for catechins than site a as the highest affinity constant disappears in the H568A-STAT1 mutant.	Catechin	50-59	signal transducer and activator of transcription 1	Homo sapiens	129-134
24255956-9	2014	Furthermore, Janus kinase 2 (JAK2) kinase assay data suggest that the contemporary presence in vitro of STAT1 and catechins inhibits JAK2-elicited STAT1 phosphorylation.	Catechin	114-123	Janus kinase 2	Homo sapiens	13-27
24255956-9	2014	Furthermore, Janus kinase 2 (JAK2) kinase assay data suggest that the contemporary presence in vitro of STAT1 and catechins inhibits JAK2-elicited STAT1 phosphorylation.	Catechin	114-123	Janus kinase 2	Homo sapiens	133-137
24255956-9	2014	Furthermore, Janus kinase 2 (JAK2) kinase assay data suggest that the contemporary presence in vitro of STAT1 and catechins inhibits JAK2-elicited STAT1 phosphorylation.	Catechin	114-123	signal transducer and activator of transcription 1	Homo sapiens	147-152
24255956-10	2014	The very tight catechin-STAT1 interaction prevents STAT1 phosphorylation and represents a novel, specific and efficient molecular mechanism for the inhibition of STAT1 activation.	Catechin	15-23	signal transducer and activator of transcription 1	Homo sapiens	24-29
24255956-10	2014	The very tight catechin-STAT1 interaction prevents STAT1 phosphorylation and represents a novel, specific and efficient molecular mechanism for the inhibition of STAT1 activation.	Catechin	15-23	signal transducer and activator of transcription 1	Homo sapiens	51-56
24255956-10	2014	The very tight catechin-STAT1 interaction prevents STAT1 phosphorylation and represents a novel, specific and efficient molecular mechanism for the inhibition of STAT1 activation.	Catechin	15-23	signal transducer and activator of transcription 1	Homo sapiens	51-56
24262486-3	2014	In the present work, the preventive effect of EC and a cocoa polyphenolic extract (CPE) on insulin signalling and on both glucose production and uptake are studied in insulin-responsive human HepG2 cells treated with high glucose.	Catechin	46-48	insulin	Homo sapiens	91-98
24262486-3	2014	In the present work, the preventive effect of EC and a cocoa polyphenolic extract (CPE) on insulin signalling and on both glucose production and uptake are studied in insulin-responsive human HepG2 cells treated with high glucose.	Catechin	46-48	insulin	Homo sapiens	167-174
25004880-12	2014	Results showed that quercetin and catechin significantly decreased the proteins expression of iNOS, COX-2 and phospho-JNK.	Catechin	34-42	cox2	Nelumbo nucifera	100-105
24353343-3	2014	Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered.	Catechin	137-148	transcription factor MYB113-like	Malus domestica	31-36
24465854-10	2014	Selected normalizers for mRNA quantification were tested and validated on expression of NAD(P)H: quinone oxidoreductase, biotransformation enzyme known to be modified by catechins.	Catechin	170-179	crystallin, zeta	Mus musculus	97-119
25004880-13	2014	Besides, the mRNAs and levels of IL-6 and TNF-alpha also decreased by quercetin and catechin treatment in LPS-induced RAW264.7 cells.	Catechin	84-92	interleukin 6	Mus musculus	33-37
25004880-13	2014	Besides, the mRNAs and levels of IL-6 and TNF-alpha also decreased by quercetin and catechin treatment in LPS-induced RAW264.7 cells.	Catechin	84-92	tumor necrosis factor	Mus musculus	42-51
24176923-0	2014	(-)-Epicatechin regenerates the chlorinating activity of myeloperoxidase in vitro and in neutrophil granulocytes.	Catechin	0-15	myeloperoxidase	Homo sapiens	57-72
25431153-13	2014	This study has presented the various effects of naturally occurring anti pancreatic cancer compounds Catechin, Wedelolactones that inhibits Cyclin Dependent Kinase 4.	Catechin	101-109	cyclin dependent kinase 4	Homo sapiens	140-165
24492725-4	2014	Coumarins, flavonols, and catechin inhibited hMATE1 activity.	Catechin	26-34	solute carrier family 47 member 1	Homo sapiens	45-51
23701564-6	2014	Intake of representative polyphenols (flavones, flavone-3-ols, catechins, anthocyanidins, flavanones, procyanidins, and resveratrol) can improve a skewed Th1/Th2 balance and suppress antigen-specific IgE antibody formation.	Catechin	63-72	negative elongation factor complex member C/D	Homo sapiens	154-157
24444972-4	2014	Through single fungal fermentation, it was proved that catechins and theanine were the precursors of puerins I-VIII.	Catechin	55-64	cytochrome c oxidase subunit 8A	Homo sapiens	111-115
24176923-4	2014	In this work we tested the ability of the flavonoid (-)-epicatechin to regenerate this enzymatic activity both in vitro at the isolated MPO-H2O2-Cl(-) system and ex vivo in human PMNs.	Catechin	52-67	myeloperoxidase	Homo sapiens	136-139
24176923-7	2014	The in vitro- and ex vivo-results concordantly show that (-)-epicatechin is a suitable substrate to overcome a compound II accumulation of MPO which was experimentally forced by applying excess hydrogen peroxide.	Catechin	57-72	myeloperoxidase	Homo sapiens	139-142
24610996-5	2014	Only six compounds, cyanidin, quercetin, silybin, cyanin, (+)-catechin and (-)-epicatechin, of all examined in this study polyphenols caused the inhibition of thrombin amidolytic activity.	Catechin	58-70	coagulation factor II, thrombin	Homo sapiens	159-167
24314870-8	2014	(-)-Epicatechin decreases myostatin and beta-galactosidase and increases levels of markers of muscle growth.	Catechin	0-15	galactosidase, beta 1	Mus musculus	40-58
24610996-5	2014	Only six compounds, cyanidin, quercetin, silybin, cyanin, (+)-catechin and (-)-epicatechin, of all examined in this study polyphenols caused the inhibition of thrombin amidolytic activity.	Catechin	75-90	coagulation factor II, thrombin	Homo sapiens	159-167
24044655-10	2013	The expression of SOD, OPN, MDA, OPN and 8-OHdG, were increased after EG administration and this increase was diminished by catechin.	Catechin	124-132	secreted phosphoprotein 1	Rattus norvegicus	33-36
23954456-7	2013	Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells.	Catechin	0-8	BCL2 apoptosis regulator	Homo sapiens	23-28
23954456-7	2013	Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells.	Catechin	0-8	cytochrome c, somatic	Homo sapiens	55-67
23954456-7	2013	Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells.	Catechin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	101-104
23954456-7	2013	Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells.	Catechin	0-8	caspase 3	Homo sapiens	106-118
23954456-7	2013	Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells.	Catechin	0-8	tumor protein p53	Homo sapiens	123-126
24012613-12	2013	SIGNIFICANCE: Data suggest the involvement of the nitric oxide-cyclic GMP-K(+) channel pathway as well as activation of 5-HT1A and 5HT1B, and at a lesser extent, 5-HT1D, but not opioid, receptors in the antinociceptive effect of epicatechin in diabetic rats.	Catechin	229-240	5-hydroxytryptamine receptor 1A	Rattus norvegicus	120-136
24308601-9	2013	Recombinant TcLAR protein converted leucoanthocyanidin to catechin in vitro.	Catechin	58-66	leucoanthocyanidin reductase	Theobroma cacao	12-17
24308601-11	2013	Overexpressing TcLAR in Arabidopsis ldox mutant also resulted in elevated synthesis of not only catechin but also epicatechin.	Catechin	96-104	leucoanthocyanidin reductase	Theobroma cacao	15-20
24308601-11	2013	Overexpressing TcLAR in Arabidopsis ldox mutant also resulted in elevated synthesis of not only catechin but also epicatechin.	Catechin	114-125	leucoanthocyanidin reductase	Theobroma cacao	15-20
24112193-0	2013	Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway.	Catechin	36-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
24004580-0	2013	Orally supplemented catechin increases heme amounts and catalase activities in rat heart blood mitochondria: a comparison between middle-aged and young rats.	Catechin	20-28	catalase	Rattus norvegicus	56-64
24004580-7	2013	We found that catechin induces an increase in blood mitochondrial heme amounts and is associated with an increase in blood mitochondrial CAT activity which is surprisingly higher in middle-aged rats as compared to young rats.	Catechin	14-22	catalase	Rattus norvegicus	137-140
24004580-8	2013	This would imply that orally supplemented catechin induces heme increase that preferentially favours CAT activity and is more beneficial to the middle-aged rats.	Catechin	42-50	catalase	Rattus norvegicus	101-104
23791569-5	2013	Results indicate that the flavanol (-)-epicatechin and derivatives are capable of stimulating mitochondrial function as assessed by citrate synthase activity as well as induction of structural (porin, mitofilin) and oxidative phosporylation protein levels (complex I and II).	Catechin	35-50	citrate synthase	Bos taurus	132-148
23578620-5	2013	The most important phenols in apple are epicatechin, catechin and their polymeric structures, which have been identified as substrates of the polyphenoloxidase (PPO).	Catechin	40-51	polyphenol oxidase, chloroplastic	Malus domestica	142-159
23578620-5	2013	The most important phenols in apple are epicatechin, catechin and their polymeric structures, which have been identified as substrates of the polyphenoloxidase (PPO).	Catechin	40-51	polyphenol oxidase, chloroplastic	Malus domestica	161-164
23578620-5	2013	The most important phenols in apple are epicatechin, catechin and their polymeric structures, which have been identified as substrates of the polyphenoloxidase (PPO).	Catechin	43-51	polyphenol oxidase, chloroplastic	Malus domestica	142-159
23578620-5	2013	The most important phenols in apple are epicatechin, catechin and their polymeric structures, which have been identified as substrates of the polyphenoloxidase (PPO).	Catechin	43-51	polyphenol oxidase, chloroplastic	Malus domestica	161-164
23470311-7	2013	Catechins suppressed the running-induced increases in plasma creatine phosphokinase levels by 52%; this was also true of the carbonylated protein content of the soleus muscle by 17% (P &lt; 0.05), malondialdehyde levels by 32% in the gastrocnemius muscle, and myeloperoxidase activity of the gastrocnemius by 22% (P &lt; 0.05).	Catechin	0-9	myeloperoxidase	Mus musculus	260-275
23714698-9	2013	Furthermore, catechin treatment restored GSH levels, and significantly increased dopamine and DOPAC content, and TH-immunoreactivity in 6-OHDA-lesioned rats.	Catechin	13-21	tyrosine hydroxylase	Rattus norvegicus	113-115
23874895-9	2013	EC treatment markedly attenuated the expression of p-JNK, p-38, and cleaved caspase-3 after irradiation in the HaCaT cells.	Catechin	0-2	mitogen-activated protein kinase 14	Homo sapiens	58-62
23894334-8	2013	Annexin V/PI assay demonstrated that apoptosis increased with increase in the concentration of CD-3.	Catechin	95-99	annexin A5	Homo sapiens	0-9
23760261-2	2013	In this context, we have examined five classes of plant-derived flavonoids (flavonols, flavones, flavanones, catechins, and cyanidin) for their ability to regulate cytokine release induced by the Toll-like receptor 2 (TLR2) agonist Pam3CSK4.	Catechin	109-118	toll like receptor 2	Homo sapiens	196-216
23840454-0	2013	Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.	Catechin	43-52	fms related receptor tyrosine kinase 3	Homo sapiens	14-18
23863773-1	2013	Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed.	Catechin	10-18	dihydrofolate reductase	Homo sapiens	149-172
23863773-1	2013	Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed.	Catechin	10-18	dihydrofolate reductase	Homo sapiens	174-178
23863773-3	2013	Polyphenols with a catechin configuration were better DHFR inhibitors than those with an epicatechin configuration.	Catechin	19-27	dihydrofolate reductase	Homo sapiens	54-58
23333093-0	2013	Green tea catechin leads to global improvement among Alzheimer"s disease-related phenotypes in NSE/hAPP-C105 Tg mice.	Catechin	10-18	enolase 2, gamma neuronal	Mus musculus	95-98
23333093-0	2013	Green tea catechin leads to global improvement among Alzheimer"s disease-related phenotypes in NSE/hAPP-C105 Tg mice.	Catechin	10-18	amyloid beta precursor protein	Homo sapiens	99-103
23840454-0	2013	Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.	Catechin	43-52	fms related receptor tyrosine kinase 3	Homo sapiens	56-60
23782751-0	2013	Inhibitory effect of catechin-related compounds on renin activity.	Catechin	21-29	renin	Homo sapiens	51-56
23567315-0	2013	In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.	Catechin	63-75	cytochrome b5 type A	Homo sapiens	121-134
23567315-0	2013	In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.	Catechin	77-92	cytochrome b5 type A	Homo sapiens	121-134
23497868-0	2013	Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1.	Catechin	21-30	solute carrier family 15 member 1	Homo sapiens	169-174
23782751-2	2013	The inhibitory effect of catechin-related compounds on renin was investigated in this work.	Catechin	25-33	renin	Homo sapiens	55-60
23252598-7	2013	Treatment for 30 days with (-)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (-)-epicatechin cessation.	Catechin	27-42	vascular endothelial growth factor A	Rattus norvegicus	137-141
23252598-7	2013	Treatment for 30 days with (-)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (-)-epicatechin cessation.	Catechin	27-42	vascular endothelial growth factor A	Rattus norvegicus	143-180
23252598-7	2013	Treatment for 30 days with (-)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (-)-epicatechin cessation.	Catechin	27-42	thrombospondin 1	Rattus norvegicus	212-217
23252598-7	2013	Treatment for 30 days with (-)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (-)-epicatechin cessation.	Catechin	27-42	thrombospondin 1	Rattus norvegicus	219-235
23252598-7	2013	Treatment for 30 days with (-)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (-)-epicatechin cessation.	Catechin	287-302	vascular endothelial growth factor A	Rattus norvegicus	137-141
23671928-0	2013	Green tea catechins can bind and modify ERp57/PDIA3 activity.	Catechin	10-19	protein disulfide isomerase family A member 3	Homo sapiens	40-45
23638734-0	2013	EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1alpha and NFkappaB, and VEGF expression.	Catechin	24-32	hypoxia inducible factor 1, alpha subunit	Mus musculus	114-124
23638734-0	2013	EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1alpha and NFkappaB, and VEGF expression.	Catechin	24-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-137
23638734-0	2013	EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1alpha and NFkappaB, and VEGF expression.	Catechin	24-32	vascular endothelial growth factor A	Mus musculus	143-147
23597018-4	2013	The high sensitivity (detection limit of 5 muM) and selectivity are achieved through a strong interaction between Ti atoms of TiO2 nanomaterial and enediol group of catechin.	Catechin	165-173	latexin	Homo sapiens	43-46
23651430-3	2013	Catechin polymers extracted with 20% ethanol had potent inhibitory activity against alpha-glucosidase with an IC50 value of 4 mug/mL, and they were present as a mixture of dimers, trimers, and tetramers.	Catechin	0-8	sucrase-isomaltase	Homo sapiens	84-101
23290096-5	2013	The catechin-rich OPL dose dependently increased the OVX bone density and structure, femur and tibia masses (by +8% and +12% respectively), ash (by +30% and +20% respectively), calcium (by +3% and +5%), and T-ALP concentrations (by +76%) compared with the OVX rats.	Catechin	4-12	PDZ and LIM domain 3	Rattus norvegicus	209-212
23671928-0	2013	Green tea catechins can bind and modify ERp57/PDIA3 activity.	Catechin	10-19	protein disulfide isomerase family A member 3	Homo sapiens	46-51
23671928-2	2013	In this study the effects of four green tea catechins on protein ERp57, also known as protein disulfide isomerase isoform A3 (PDIA3), have been investigated in an in vitro model.	Catechin	44-53	protein disulfide isomerase family A member 3	Homo sapiens	65-70
23671928-2	2013	In this study the effects of four green tea catechins on protein ERp57, also known as protein disulfide isomerase isoform A3 (PDIA3), have been investigated in an in vitro model.	Catechin	44-53	protein disulfide isomerase family A member 3	Homo sapiens	86-124
23671928-2	2013	In this study the effects of four green tea catechins on protein ERp57, also known as protein disulfide isomerase isoform A3 (PDIA3), have been investigated in an in vitro model.	Catechin	44-53	protein disulfide isomerase family A member 3	Homo sapiens	126-131
23671928-3	2013	METHODS: The interaction of catechins with ERp57 was explored by fluorescence quenching and surface plasmon resonance techniques and their effect on ERp57 activities was investigated.	Catechin	28-37	protein disulfide isomerase family A member 3	Homo sapiens	43-48
23671928-5	2013	The effects of these catechins on ERp57 properties were also investigated and a moderate inhibition of the reductase activity of ERp57 was observed as well as a strong inhibition of ERp57 DNA binding activity.	Catechin	21-30	protein disulfide isomerase family A member 3	Homo sapiens	34-39
23671928-5	2013	The effects of these catechins on ERp57 properties were also investigated and a moderate inhibition of the reductase activity of ERp57 was observed as well as a strong inhibition of ERp57 DNA binding activity.	Catechin	21-30	protein disulfide isomerase family A member 3	Homo sapiens	129-134
23671928-5	2013	The effects of these catechins on ERp57 properties were also investigated and a moderate inhibition of the reductase activity of ERp57 was observed as well as a strong inhibition of ERp57 DNA binding activity.	Catechin	21-30	protein disulfide isomerase family A member 3	Homo sapiens	129-134
23671928-6	2013	CONCLUSIONS: Considering the high affinity of galloylated catechins for ERp57 and their capability to inhibit ERp57 binding to other macromolecular ligands, some effects of catechins interaction with this protein on eukaryotic cells may be expected.	Catechin	58-67	protein disulfide isomerase family A member 3	Homo sapiens	72-77
23671928-6	2013	CONCLUSIONS: Considering the high affinity of galloylated catechins for ERp57 and their capability to inhibit ERp57 binding to other macromolecular ligands, some effects of catechins interaction with this protein on eukaryotic cells may be expected.	Catechin	58-67	protein disulfide isomerase family A member 3	Homo sapiens	110-115
23671928-7	2013	GENERAL SIGNIFICANCE: This study provides information to better understand the molecular mechanisms underlying the biological activities of catechins and to design new polyphenol-based ERp57-specific inhibitors.	Catechin	140-149	protein disulfide isomerase family A member 3	Homo sapiens	185-190
23714466-2	2013	Preclinical studies over the last 25 years implicate constituent green tea catechins, epigallocatechin-3-gallate (EGCG) being the predominant form, as the main mechanistic ingredient in the observed biologic effects, which vary from proapoptotic effects to inhibition of androgen receptor and signal transduction pathways.	Catechin	75-84	androgen receptor	Homo sapiens	271-288
22704779-0	2013	Different effects of catechin on angiogenesis and inflammation depending on VEGF levels.	Catechin	21-29	vascular endothelial growth factor A	Homo sapiens	76-80
22704779-4	2013	The purpose of the current study was to investigate the effects of 0.1-100 muM catechin on endothelial cells (EC) and vascular smooth muscle cells (VSMC) regarding angiogenic and inflammatory processes.	Catechin	79-87	latexin	Homo sapiens	75-78
22704779-5	2013	Catechin modulation of angiogenesis and inflammation was also evaluated in vivo using different models of angiogenesis: one physiological (skin wound-healing assay) and another one resembling pathological angiogenesis, exhibiting higher vascular endothelial growth factor (VEGF)-A stimulation (Matrigel plug assay).	Catechin	0-8	vascular endothelial growth factor A	Homo sapiens	237-271
22704779-5	2013	Catechin modulation of angiogenesis and inflammation was also evaluated in vivo using different models of angiogenesis: one physiological (skin wound-healing assay) and another one resembling pathological angiogenesis, exhibiting higher vascular endothelial growth factor (VEGF)-A stimulation (Matrigel plug assay).	Catechin	0-8	vascular endothelial growth factor A	Homo sapiens	273-277
22704779-6	2013	The in vitro results showed that 100 muM catechin increased viability (to 165.58% and to 165.34%) and decreased apoptosis (53.45% and 92.65%) and proliferation (33.19% and 23.36%) of EC and VSMC, respectively.	Catechin	41-49	latexin	Homo sapiens	37-40
22704779-8	2013	Nevertheless, catechin diminished in vitro inflammatory modulators such as tumor necrosis factor alpha (58.66% for human umbilical vein endothelial cells and 85.46% for human aortic smooth muscle cells) and nuclear factor kappa-B (38.43% for VSMC).	Catechin	14-22	tumor necrosis factor	Homo sapiens	75-102
22704779-10	2013	Altogether, the current study showed that catechin has different effects in angiogenesis and inflammation depending on VEGF-A levels.	Catechin	42-50	vascular endothelial growth factor A	Homo sapiens	119-125
22704780-0	2013	Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo.	Catechin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
22704780-7	2013	The results indicated that catechin significantly (P&lt;.05) decreased the levels of lipid peroxidation (40.5%) and reactive oxygen species (30.0%), and increased the activity of intracellular antioxidant enzymes glutathione peroxidase, glutathione reductase and total sulfhydryl groups.	Catechin	27-35	glutathione-disulfide reductase	Homo sapiens	237-258
22704780-9	2013	Western blot analysis revealed that catechin stimulated a time-dependent increase in both the nuclear factor erythroid 2-related factor 2 and total heme oxygenase-1 protein expression in Int-407 cells.	Catechin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	94-137
22704780-9	2013	Western blot analysis revealed that catechin stimulated a time-dependent increase in both the nuclear factor erythroid 2-related factor 2 and total heme oxygenase-1 protein expression in Int-407 cells.	Catechin	36-44	heme oxygenase 1	Homo sapiens	148-164
23206800-5	2013	While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.	Catechin	15-24	catechol-O-methyltransferase	Homo sapiens	68-96
23206800-5	2013	While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.	Catechin	15-24	catechol-O-methyltransferase	Homo sapiens	98-102
23311874-7	2013	(-)-Epicatechin activated three receptors, TAS2R4, TAS2R5, and TAS2R39, whereas only two receptors, TAS2R5 and TAS2R39, responded to PGG.	Catechin	0-15	taste 2 receptor member 4	Homo sapiens	43-49
23311874-7	2013	(-)-Epicatechin activated three receptors, TAS2R4, TAS2R5, and TAS2R39, whereas only two receptors, TAS2R5 and TAS2R39, responded to PGG.	Catechin	0-15	taste 2 receptor member 5	Homo sapiens	51-57
23311874-7	2013	(-)-Epicatechin activated three receptors, TAS2R4, TAS2R5, and TAS2R39, whereas only two receptors, TAS2R5 and TAS2R39, responded to PGG.	Catechin	0-15	taste 2 receptor member 39	Homo sapiens	63-70
23231348-10	2013	Adding glutathione to the detergent-based assay, as used in these studies to measure furin processing activity, strongly reduced inhibition by a number of polyphenols (catechins, gallic acid and quercetin), while the effect on the genuine inhibitor nona-D-arginine remained unchanged.	Catechin	168-177	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
23268924-2	2013	The objective of the present study was to evaluate the effects of green tea extract (GTE, total catechins 86.5%, w/w) and (-)-epigallocatechin-3-gallate (EGCG) on the activities of CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP3A in vitro, using pooled human liver and intestinal microsomes.	Catechin	96-105	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	181-187
24018685-2	2013	Among the 25 human bitter-taste receptors (TAS2Rs), we found that hTAS2R14 responded to catechins, in addition to hTAS2R39, a known catechin receptor.	Catechin	88-97	taste 2 receptor member 14	Homo sapiens	66-74
24018685-3	2013	Although hTAS2R14 responded to (-)-epicatechin gallate and (-)-epigallocatechin gallate, it did not respond to (-)-epicatechin and (-)-epigallocatechin.	Catechin	31-46	taste 2 receptor member 14	Homo sapiens	9-17
23268924-9	2013	These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A.	Catechin	37-46	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	106-112
22974973-1	2013	BACKGROUND: Green tea catechins have been hypothesized to increase energy expenditure and fat oxidation by inhibiting catechol-O-methyltransferase (COMT) and thus promoting more sustained adrenergic stimulation.	Catechin	22-31	catechol-O-methyltransferase	Homo sapiens	118-146
23268924-9	2013	These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A.	Catechin	37-46	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	117-123
23268924-9	2013	These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A.	Catechin	37-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-144
22260360-9	2013	Long-term treatment (24 h) with these compounds and other catechins suppresses the viability of HeLa cells with a relative effectiveness reminiscent of their in vitro PP1c-inhibitory potencies.	Catechin	58-67	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	167-171
23573138-5	2013	Five compounds, 1,3- and 1,5-dicaffeoylquinic acid, ginkgolic acids (15 : 1) and (17 : 1), and epicatechin, significantly inhibited hOAT3 transport under similar conditions.	Catechin	95-106	solute carrier family 22 member 8	Homo sapiens	132-137
23573138-6	2013	Only catechin inhibited hOAT4.	Catechin	5-13	solute carrier family 22 member 11	Homo sapiens	24-29
22974973-1	2013	BACKGROUND: Green tea catechins have been hypothesized to increase energy expenditure and fat oxidation by inhibiting catechol-O-methyltransferase (COMT) and thus promoting more sustained adrenergic stimulation.	Catechin	22-31	catechol-O-methyltransferase	Homo sapiens	148-152
23180627-5	2013	Lactase is inhibited by green tea catechins.	Catechin	34-43	lactase	Homo sapiens	0-7
23180627-6	2013	Once produced in the gut by digestion, glucose is absorbed by SGLT1 and GLUT2 transporters, inhibited by flavonols and flavonol glycosides, phlorizin and green tea catechins.	Catechin	164-173	solute carrier family 5 member 1	Homo sapiens	62-67
23180627-6	2013	Once produced in the gut by digestion, glucose is absorbed by SGLT1 and GLUT2 transporters, inhibited by flavonols and flavonol glycosides, phlorizin and green tea catechins.	Catechin	164-173	solute carrier family 2 member 2	Homo sapiens	72-77
23225437-6	2012	mRNA and protein expression levels of BCL2-associated X protein (BAX) and p53 were up-regulated and those of B-cell lymphoma-2 (BCL2) were down-regulated, while p21 mRNA levels were significantly increased in cells treated with (-)-epicatechin in a concentration-dependent manner.	Catechin	228-243	BCL2 associated X, apoptosis regulator	Homo sapiens	38-63
23205879-4	2012	Here the inhibition mechanism of green tea polyphenols, catechins, on amyloid fibril formation of the IAPP fragment (IAPP22-27), which is of sufficient length for formation of beta-sheet-containing amyloid fibrils, was investigated by means of kinetic analysis.	Catechin	56-65	islet amyloid polypeptide	Homo sapiens	102-106
22424477-4	2012	Catechin also induced 3-5-fold changes in NQO1 transcription, whereas quercetin had less effect on NQO1 mRNA induction in infant cells.	Catechin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	42-46
23225437-6	2012	mRNA and protein expression levels of BCL2-associated X protein (BAX) and p53 were up-regulated and those of B-cell lymphoma-2 (BCL2) were down-regulated, while p21 mRNA levels were significantly increased in cells treated with (-)-epicatechin in a concentration-dependent manner.	Catechin	228-243	BCL2 apoptosis regulator	Homo sapiens	109-126
23225437-6	2012	mRNA and protein expression levels of BCL2-associated X protein (BAX) and p53 were up-regulated and those of B-cell lymphoma-2 (BCL2) were down-regulated, while p21 mRNA levels were significantly increased in cells treated with (-)-epicatechin in a concentration-dependent manner.	Catechin	228-243	BCL2 apoptosis regulator	Homo sapiens	38-42
22985936-6	2012	At the vascular level, none of the treatments modified NOS expression, but (-)-epicatechin administration avoided the L-NAME-mediated decrease in eNOS activity and increase in both superoxide anion production and NOX subunit p47(phox) expression.	Catechin	75-90	NSFL1 cofactor	Rattus norvegicus	225-228
22080234-6	2012	Catechin administration significantly decreased MDA level and significantly increased CAT, GSH-Px and SOD activities.	Catechin	0-8	catalase	Rattus norvegicus	86-89
22080234-6	2012	Catechin administration significantly decreased MDA level and significantly increased CAT, GSH-Px and SOD activities.	Catechin	0-8	glutathione peroxidase 1	Rattus norvegicus	91-97
22425757-0	2012	(-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes.	Catechin	0-15	tumor necrosis factor	Homo sapiens	25-33
22425757-0	2012	(-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes.	Catechin	0-15	insulin	Homo sapiens	104-111
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	tumor necrosis factor	Homo sapiens	106-114
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	insulin	Homo sapiens	180-187
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	nuclear factor kappa B subunit 1	Homo sapiens	200-209
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	254-258
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	peroxisome proliferator activated receptor gamma	Homo sapiens	264-312
22425757-4	2012	The aim of this study was to investigate the capacity of (-)-epicatechin to prevent tumor necrosis alpha (TNFalpha)-induced activation of cell signals involved in inflammation and insulin resistance (NF-kappaB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor gamma (PPARgamma)) in differentiated white adipocytes (3T3-L1).	Catechin	57-72	peroxisome proliferator activated receptor gamma	Homo sapiens	314-323
22425757-6	2012	(-)-Epicatechin caused a dose (0.5-10 muM)-dependent decrease in TNFalpha-mediated JNK, ERK1/2, and p-38 phosphorylation, and nuclear AP-1-DNA binding.	Catechin	0-15	tumor necrosis factor	Homo sapiens	65-73
22425757-6	2012	(-)-Epicatechin caused a dose (0.5-10 muM)-dependent decrease in TNFalpha-mediated JNK, ERK1/2, and p-38 phosphorylation, and nuclear AP-1-DNA binding.	Catechin	0-15	mitogen-activated protein kinase 8	Homo sapiens	83-86
22425757-6	2012	(-)-Epicatechin caused a dose (0.5-10 muM)-dependent decrease in TNFalpha-mediated JNK, ERK1/2, and p-38 phosphorylation, and nuclear AP-1-DNA binding.	Catechin	0-15	mitogen-activated protein kinase 3	Homo sapiens	88-94
22425757-6	2012	(-)-Epicatechin caused a dose (0.5-10 muM)-dependent decrease in TNFalpha-mediated JNK, ERK1/2, and p-38 phosphorylation, and nuclear AP-1-DNA binding.	Catechin	0-15	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-138
22425757-7	2012	(-)-Epicatechin also inhibited TNFalpha-triggered activation of the NF-kappaB signaling cascade, preventing TNFalpha-mediated p65 nuclear transport and nuclear NF-kappaB-DNA binding.	Catechin	0-15	tumor necrosis factor	Homo sapiens	31-39
22425757-7	2012	(-)-Epicatechin also inhibited TNFalpha-triggered activation of the NF-kappaB signaling cascade, preventing TNFalpha-mediated p65 nuclear transport and nuclear NF-kappaB-DNA binding.	Catechin	0-15	nuclear factor kappa B subunit 1	Homo sapiens	68-77
22425757-7	2012	(-)-Epicatechin also inhibited TNFalpha-triggered activation of the NF-kappaB signaling cascade, preventing TNFalpha-mediated p65 nuclear transport and nuclear NF-kappaB-DNA binding.	Catechin	0-15	tumor necrosis factor	Homo sapiens	108-116
22425757-7	2012	(-)-Epicatechin also inhibited TNFalpha-triggered activation of the NF-kappaB signaling cascade, preventing TNFalpha-mediated p65 nuclear transport and nuclear NF-kappaB-DNA binding.	Catechin	0-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
22425757-7	2012	(-)-Epicatechin also inhibited TNFalpha-triggered activation of the NF-kappaB signaling cascade, preventing TNFalpha-mediated p65 nuclear transport and nuclear NF-kappaB-DNA binding.	Catechin	0-15	nuclear factor kappa B subunit 1	Homo sapiens	160-169
22425757-8	2012	(-)-Epicatechin also attenuated the TNFalpha-mediated downregulation of PPARgamma expression and decreased nuclear DNA binding.	Catechin	0-15	tumor necrosis factor	Homo sapiens	36-44
22425757-8	2012	(-)-Epicatechin also attenuated the TNFalpha-mediated downregulation of PPARgamma expression and decreased nuclear DNA binding.	Catechin	0-15	peroxisome proliferator activated receptor gamma	Homo sapiens	72-81
22425757-9	2012	Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling.	Catechin	13-28	tumor necrosis factor	Homo sapiens	39-47
22425757-9	2012	Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling.	Catechin	13-28	C-C motif chemokine ligand 2	Homo sapiens	89-94
22425757-9	2012	Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling.	Catechin	13-28	interleukin 6	Homo sapiens	96-109
22933302-10	2012	Such a protective effect of epicatechin might be attributed to decreased oxidative stress and reduced ERK activity.	Catechin	28-39	mitogen-activated protein kinase 1	Mus musculus	102-105
22425757-9	2012	Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling.	Catechin	13-28	tumor necrosis factor	Homo sapiens	111-119
22425757-9	2012	Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling.	Catechin	13-28	insulin	Homo sapiens	197-204
22425757-10	2012	In conclusion, (-)-epicatechin can attenuate TNFalpha-mediated triggering of signaling cascades involved in inflammation and insulin resistance.	Catechin	15-30	tumor necrosis factor	Homo sapiens	45-53
22425757-10	2012	In conclusion, (-)-epicatechin can attenuate TNFalpha-mediated triggering of signaling cascades involved in inflammation and insulin resistance.	Catechin	15-30	insulin	Homo sapiens	125-132
23055502-5	2012	Importantly, we also identified in this study that epigallocatechin gallate (EGCG), a green tea-derived catechin, acts as a potent suppressor of dopaminergic and mitochondrial dysfunction in both mutant LRRK2 and parkin-null flies.	Catechin	59-67	Leucine-rich repeat kinase	Drosophila melanogaster	203-208
23009399-0	2012	Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria.	Catechin	77-86	monoamine oxidase A	Mus musculus	94-113
22324650-4	2012	FLS silencing reduced flavonol content 17-53%, while it increased catechin and epicatechin content 51-93% and 18-27%, respectively.	Catechin	66-74	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	0-3
22190076-0	2012	Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model.	Catechin	0-11	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	43-47
22190076-8	2012	CP and epicatechin treatments induced no effect on normal PDE cells, however, caused a decrease in the (i) proliferation, (ii) guanosine triphosphate (GTP)-bound Ras protein, (iii) Akt phosphorylation and (iv) NF-kappaB transcriptional activity of premalignant and malignant Kras-activated PDE cells.	Catechin	7-18	thymoma viral proto-oncogene 1	Mus musculus	181-184
22190076-8	2012	CP and epicatechin treatments induced no effect on normal PDE cells, however, caused a decrease in the (i) proliferation, (ii) guanosine triphosphate (GTP)-bound Ras protein, (iii) Akt phosphorylation and (iv) NF-kappaB transcriptional activity of premalignant and malignant Kras-activated PDE cells.	Catechin	7-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
22190076-8	2012	CP and epicatechin treatments induced no effect on normal PDE cells, however, caused a decrease in the (i) proliferation, (ii) guanosine triphosphate (GTP)-bound Ras protein, (iii) Akt phosphorylation and (iv) NF-kappaB transcriptional activity of premalignant and malignant Kras-activated PDE cells.	Catechin	7-18	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	275-279
22859681-8	2012	Epicatechin and catechin biosynthesis is under the control of the biosynthetic enzymes anthocyanidin reductase (ANR) and leucoanthocyanidin reductase (LAR1), respectively.	Catechin	0-11	leucoanthocyanidin reductase-like	Malus domestica	151-155
22859681-8	2012	Epicatechin and catechin biosynthesis is under the control of the biosynthetic enzymes anthocyanidin reductase (ANR) and leucoanthocyanidin reductase (LAR1), respectively.	Catechin	3-11	leucoanthocyanidin reductase-like	Malus domestica	151-155
23741252-3	2012	In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the inhibition of IDO expression induced by interferon (IFN)-gamma in human CRC cells.	Catechin	61-69	indoleamine 2,3-dioxygenase 1	Homo sapiens	140-143
23741252-3	2012	In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the inhibition of IDO expression induced by interferon (IFN)-gamma in human CRC cells.	Catechin	61-69	interferon gamma	Homo sapiens	166-188
22324650-11	2012	Results suggest that flavan-3-ols (catechin) might be increasing activity of GR, Apx and CAT by elevating their mRNAs levels.	Catechin	35-43	catalase isozyme 1	Nicotiana tabacum	89-92
22324650-4	2012	FLS silencing reduced flavonol content 17-53%, while it increased catechin and epicatechin content 51-93% and 18-27%, respectively.	Catechin	79-90	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	0-3
22324650-5	2012	The silenced lines showed a significant increase in expression of genes for dihydroflavonol reductase and anthocyanidin synthase, a downstream gene towards epicatechin production, with no significant change in expression of other genes of the flavonoid pathway.	Catechin	156-167	leucoanthocyanidin dioxygenase-like	Nicotiana tabacum	106-128
22324650-11	2012	Results suggest that flavan-3-ols (catechin) might be increasing activity of GR, Apx and CAT by elevating their mRNAs levels.	Catechin	35-43	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	81-84
22670643-7	2012	This study demonstrates that GTE and its major catechin, EGCG, have immunoregulatory effects on human IgE responses.	Catechin	47-55	immunoglobulin heavy constant epsilon	Homo sapiens	102-105
22970031-5	2012	Both let-7a-1 and let-7g were detected in the human lung cancer cells treated with tea catechins.	Catechin	87-96	microRNA let-7a-1	Homo sapiens	5-13
22574829-0	2012	Antiproliferative effect of catechin in GRX cells.	Catechin	28-36	glutaredoxin	Homo sapiens	40-43
22574829-4	2012	The objective of this study was to assess the catechin effect in GRX liver cells in activities such as cell growth and inflammation.	Catechin	46-54	glutaredoxin	Homo sapiens	65-68
22574829-5	2012	The GRX cells treatment with catechin induced a significant decrease in cell growth.	Catechin	29-37	glutaredoxin	Homo sapiens	4-7
22574829-8	2012	This study shows that catechin decreases cell growth in GRX cells and, probably, this decrease does not occur by apoptosis or autophagy but through an anti-inflammatory effect and cell cycle arrest.	Catechin	22-30	glutaredoxin	Homo sapiens	56-59
22574829-9	2012	Catechin also significantly decreased the production of TGF-beta by GRX cells, showing a significant antifibrotic effect.	Catechin	0-8	glutaredoxin	Homo sapiens	68-71
22970031-5	2012	Both let-7a-1 and let-7g were detected in the human lung cancer cells treated with tea catechins.	Catechin	87-96	microRNA let-7g	Homo sapiens	18-24
22970031-7	2012	In the present study, we found that tea catechins upregulated the tumor-suppressor miRs, let-7a-1 and let-7g, in lung cancer cell lines.	Catechin	40-49	microRNA let-7a-1	Homo sapiens	89-97
22970031-7	2012	In the present study, we found that tea catechins upregulated the tumor-suppressor miRs, let-7a-1 and let-7g, in lung cancer cell lines.	Catechin	40-49	microRNA let-7g	Homo sapiens	102-108
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Catechin	7-15	catalase	Rattus norvegicus	143-146
22505206-3	2012	EC, EGC and EGCG induced prostate cancer cell death, suppressed agonist-dependent androgen receptor (AR) activation and AR-regulated gene transcription.	Catechin	0-2	androgen receptor	Homo sapiens	82-99
22505206-3	2012	EC, EGC and EGCG induced prostate cancer cell death, suppressed agonist-dependent androgen receptor (AR) activation and AR-regulated gene transcription.	Catechin	0-2	androgen receptor	Homo sapiens	101-103
22505206-3	2012	EC, EGC and EGCG induced prostate cancer cell death, suppressed agonist-dependent androgen receptor (AR) activation and AR-regulated gene transcription.	Catechin	0-2	androgen receptor	Homo sapiens	120-122
22295890-0	2012	Quercetin and catechin synergistically inhibit angiotensin II-induced redox-dependent signalling pathways in vascular smooth muscle cells from hypertensive rats.	Catechin	14-22	angiotensinogen	Rattus norvegicus	47-61
22295890-2	2012	The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signalling pathways and cell behaviour.	Catechin	66-74	angiotensinogen	Rattus norvegicus	99-113
22295890-2	2012	The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signalling pathways and cell behaviour.	Catechin	66-74	angiotensinogen	Rattus norvegicus	115-120
22350517-7	2012	These studies show that rotenone toxicity of RGC-5 cells is neither necroptosis nor caspase-dependent apoptosis but involves the activation of mitogen-activated kinases and is inhibited by a JNK inhibitor, EGCG and EC.	Catechin	215-217	mitogen-activated protein kinase 8	Mus musculus	191-194
22830928-0	2012	Mechanisms of the antinociceptive action of (-) epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart &amp; Eic in rodents.	Catechin	44-59	serine (or cysteine) peptidase inhibitor, clade B, member 1c	Mus musculus	135-138
22373658-3	2012	The most widely reported method of quantifying total epicatechin in plasma and urine samples involves hydrolysis with a mixture of beta-glucuronidase and sulfatase to convert the conjugates to epicatechin aglycone which is subsequently quantified.	Catechin	53-64	arylsulfatase family member H	Homo sapiens	154-163
22238451-13	2012	This finding suggests that the ANR gene may be capable of generating catechin via an alternative route, although this mechanism is yet to be further elucidated.	Catechin	69-77	anthocyanidin reductase	Malus domestica	31-34
22268108-0	2012	Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow.	Catechin	0-8	low density lipoprotein receptor	Mus musculus	102-106
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Catechin	7-15	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-186
22071171-0	2012	Methylation of catechins and procyanidins by rat and human catechol-O-methyltransferase: metabolite profiling and molecular modeling studies.	Catechin	15-24	catechol-O-methyltransferase	Homo sapiens	59-87
22200924-0	2012	Connecting simulated, bioanalytical, and molecular docking data on the stereoselective binding of (+-)-catechin to human serum albumin.	Catechin	98-111	albumin	Homo sapiens	121-134
22200924-1	2012	The stereoselective binding of the frequently ingested nutraceutical (+-)-catechin, with demonstrated differential biological activity between enantiomers, to human serum albumin (HSA), with the largest complexation and enantioselectivity potential among the plasmatic proteins, is studied by combining simulations to optimize the experimental design, robust in vitro electrokinetic chromatographic data, and molecular docking-chiral recognition estimates.	Catechin	69-82	albumin	Homo sapiens	165-178
22071171-3	2012	This study aimed to compare the methylation of catechins and procyanidins by the enzyme catechol-O-methyltransferase (COMT) in vitro.	Catechin	47-56	catechol-O-methyltransferase	Homo sapiens	88-116
21239456-3	2012	Here, we demonstrate that catechin and quercetin have the potential to down-regulate the initial signalling molecule NF-kappaB which may further inhibit the downstream cascade including TNF-alpha and NO.	Catechin	26-34	tumor necrosis factor	Rattus norvegicus	186-195
22071171-3	2012	This study aimed to compare the methylation of catechins and procyanidins by the enzyme catechol-O-methyltransferase (COMT) in vitro.	Catechin	47-56	catechol-O-methyltransferase	Homo sapiens	118-122
21445620-0	2012	A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins.	Catechin	129-138	catechol-O-methyltransferase	Homo sapiens	45-73
21445620-4	2012	The current preliminary study was designed to investigate the impact of COMT genotype on green tea catechin absorption and metabolism in humans.	Catechin	99-107	catechol-O-methyltransferase	Homo sapiens	72-76
22269060-7	2012	Leucoanthocyanidin reductase (LAR1) co-located with a QTL cluster for the fruit flavanols catechin, epicatechin, procyanidin dimer and five unknown procyanidin oligomers identified near the top of linkage group (LG) 16, while hydroxy cinnamate/quinate transferase (HCT/HQT) co-located with a QTL for chlorogenic acid concentration mapping near the bottom of LG 17.	Catechin	90-98	leucoanthocyanidin reductase-like	Malus domestica	30-34
21780253-8	2012	These results suggest that curcumin and catechin in combination can inhibit the proliferation of HCT 15, HCT 116, as well as Hep G-2 cells efficiently through induction of apoptosis.	Catechin	40-48	DNL-type zinc finger	Homo sapiens	125-128
22269060-7	2012	Leucoanthocyanidin reductase (LAR1) co-located with a QTL cluster for the fruit flavanols catechin, epicatechin, procyanidin dimer and five unknown procyanidin oligomers identified near the top of linkage group (LG) 16, while hydroxy cinnamate/quinate transferase (HCT/HQT) co-located with a QTL for chlorogenic acid concentration mapping near the bottom of LG 17.	Catechin	100-111	leucoanthocyanidin reductase-like	Malus domestica	30-34
22178739-4	2012	In this study, we demonstrated that epigallocatechin-3-gallate (EGCG), a major tea catechin, specifically and dose-dependently activates FXR.	Catechin	44-52	nuclear receptor subfamily 1, group H, member 4	Mus musculus	137-140
22166210-5	2012	We also investigated in vitro methylation of epicatechin and epicatechin glucuronides by human catechol O-methyltransferase.	Catechin	45-56	catechol-O-methyltransferase	Homo sapiens	95-123
22423234-9	2012	In contrast, 9-month catechin further increased COX-2, p22(phox) and reduced MnSOD (P&lt;0.05).	Catechin	21-29	cytochrome c oxidase II, mitochondrial	Mus musculus	48-53
22107836-10	2012	Moreover, (+)-catechin reduced total annexin V positive cells (early and late apoptotic cells), attenuated the collapsed of MMP, and inhibited cell cycle arrested at sub-G(1) population following H(2)O(2) insult.	Catechin	10-22	annexin A5	Mus musculus	37-46
23207778-1	2012	CAT-1 capable of cleaving the C-ring of (+)-catechin and (-)-epicatechin, followed by p-dehydroxylation of the B-ring.	Catechin	40-52	GIT ArfGAP 1	Homo sapiens	0-5
23207778-1	2012	CAT-1 capable of cleaving the C-ring of (+)-catechin and (-)-epicatechin, followed by p-dehydroxylation of the B-ring.	Catechin	57-72	GIT ArfGAP 1	Homo sapiens	0-5
23221717-4	2012	Polyphenols, including catechins, curcumin, resveratrol, silibinin, and sulfurous compound alpha-lipoic acid, were found to inhibit both HOCl- and human MPO-induced Cl-Guo formation dose-dependently.	Catechin	23-32	myeloperoxidase	Homo sapiens	153-156
22045026-0	2012	Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis.	Catechin	10-18	mitogen-activated protein kinase 1	Homo sapiens	68-71
22423234-9	2012	In contrast, 9-month catechin further increased COX-2, p22(phox) and reduced MnSOD (P&lt;0.05).	Catechin	21-29	dynein cytoplasmic 1 heavy chain 1	Mus musculus	55-58
22423234-9	2012	In contrast, 9-month catechin further increased COX-2, p22(phox) and reduced MnSOD (P&lt;0.05).	Catechin	21-29	superoxide dismutase 2, mitochondrial	Mus musculus	77-82
22001745-0	2012	Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.	Catechin	0-11	endothelin 1	Rattus norvegicus	101-113
22001745-5	2012	Plasma endothelin-1 and malondialdehyde levels and urinary iso-prostaglandin F(2alpha) excretion were increased in animals of the DOCA-salt group and reduced by the epicatechin 10 mg kg(-1) treatment.	Catechin	165-176	endothelin 1	Rattus norvegicus	7-19
22001745-7	2012	However, only epicatechin at 10 mg kg(-1) reduced the rise in aortic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and p47(phox) and p22(phox) gene overexpression found in DOCA-salt animals.	Catechin	14-25	cytochrome b-245 alpha chain	Rattus norvegicus	142-151
22001745-7	2012	However, only epicatechin at 10 mg kg(-1) reduced the rise in aortic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and p47(phox) and p22(phox) gene overexpression found in DOCA-salt animals.	Catechin	14-25	cytochrome b-245 alpha chain	Rattus norvegicus	146-150
22001745-8	2012	Epicatechin increased the transcription of nuclear factor-E2-related factor-2 (Nrf2) and Nrf2 target genes in aortas from control rats.	Catechin	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
22001745-8	2012	Epicatechin increased the transcription of nuclear factor-E2-related factor-2 (Nrf2) and Nrf2 target genes in aortas from control rats.	Catechin	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
22001745-9	2012	Epicatechin also improved the impaired endothelium-dependent relaxation response to acetylcholine and increased the phosphorylation of both Akt and eNOS in aortic rings.	Catechin	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
22916242-0	2012	Influence of galloyl moiety in interaction of epicatechin with bovine serum albumin: a spectroscopic and thermodynamic characterization.	Catechin	46-57	albumin	Homo sapiens	70-83
22900152-3	2012	Hepatic fatty acid synthase (FAS) activity in the catechins + caffeine group was significantly lower, and the activities of acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase-II (CPT-II) were significantly higher, compared to the control group.	Catechin	50-59	fatty acid synthase	Mus musculus	8-27
22900152-3	2012	Hepatic fatty acid synthase (FAS) activity in the catechins + caffeine group was significantly lower, and the activities of acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase-II (CPT-II) were significantly higher, compared to the control group.	Catechin	50-59	fatty acid synthase	Mus musculus	29-32
22900152-5	2012	FAS mRNA expression levels in the catechins + caffeine group were significantly lower than in the control group.	Catechin	34-43	fatty acid synthase	Mus musculus	0-3
23284772-10	2012	Also, SMAD-2 was phosphorylated following treatment of HaCaT cells by Catechin, Tannin and alkaloids namely Arecoline, Arecaidine and Guvacine.	Catechin	70-78	SMAD family member 2	Homo sapiens	6-12
22916242-5	2012	The binding affinity of these catechins to bovine serum albumin (BSA) will govern the efficacy of their biological activity.	Catechin	30-39	albumin	Homo sapiens	50-63
21910946-6	2011	Chronic (-)-epicatechin treatment did not modify the development of hypertension and only weakly affected the endothelial dysfunction induced by L-NAME but prevented the cardiac hypertrophy, the renal parenchyma and vascular lesions and proteinuria, and blunted the prostanoid-mediated enhanced endothelium-dependent vasoconstrictor responses and the cyclo-oxygenase-2 and endothelial NO synthase (eNOS) up-regulation.	Catechin	8-23	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	351-368
22253829-4	2012	We have recently reported that epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, is able to inhibit TTR aggregation and fibril formation, "in vitro" and in a cellular system, and is also able to disrupt pre-formed amyloid fibrils "in vitro".	Catechin	39-47	transthyretin	Mus musculus	126-129
22024460-0	2012	Influence of Cd2+, Hg2+ and Pb2+ on (+)-catechin binding to bovine serum albumin studied by fluorescence spectroscopic methods.	Catechin	36-48	albumin	Homo sapiens	67-80
22024460-1	2012	The effect of heavy metal ions, Cd(2+), Hg(2+) and Pb(2+) on (+)-catechin binding to bovine serum albumin (BSA) has been investigated by spectroscopic methods.	Catechin	61-73	albumin	Homo sapiens	92-105
21903878-7	2011	Furthermore, catechins significantly inhibited the increase in oxidative stress markers immediately after downhill running, accompanied by an increase in glutathione reductase activity.	Catechin	13-22	glutathione reductase	Mus musculus	154-175
21812644-2	2011	We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver.	Catechin	49-57	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	69-72
21262865-5	2011	Results obtained showed that, the combined treatment (epicatechin + lycopene) exert its effects (100%) against toxic effects against lead by lowering the liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyle transferase (GGT) activities and decrease lipid peroixdation (MDA) and enhances the superoxide dismutase (SOD) activity.	Catechin	54-65	gamma-glutamyltransferase 1	Rattus norvegicus	257-284
21262865-5	2011	Results obtained showed that, the combined treatment (epicatechin + lycopene) exert its effects (100%) against toxic effects against lead by lowering the liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyle transferase (GGT) activities and decrease lipid peroixdation (MDA) and enhances the superoxide dismutase (SOD) activity.	Catechin	54-65	gamma-glutamyltransferase 1	Rattus norvegicus	286-289
21499987-6	2011	Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages.	Catechin	87-95	heme oxygenase 1	Homo sapiens	145-149
21499987-6	2011	Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages.	Catechin	87-95	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
21884680-7	2011	Our results show that catechin reduces the expression level of GRP78/BiP, leads to cell proliferation rates of GD cells similar levels to normal cells, and improves wound healing activity.	Catechin	22-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
21884680-7	2011	Our results show that catechin reduces the expression level of GRP78/BiP, leads to cell proliferation rates of GD cells similar levels to normal cells, and improves wound healing activity.	Catechin	22-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	69-72
21788351-7	2011	Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone.	Catechin	177-192	inner membrane protein, mitochondrial	Mus musculus	51-60
21788351-7	2011	Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone.	Catechin	177-192	nitric oxide synthase 1, neuronal	Mus musculus	69-73
21788351-7	2011	Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone.	Catechin	177-192	nitric oxide synthase 1, neuronal	Mus musculus	77-81
21788351-7	2011	Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone.	Catechin	177-192	transcription factor A, mitochondrial	Mus musculus	87-91
21788351-9	2011	The combination of (-)-epicatechin and exercise resulted in further increases in oxidative phosphorylation-complex proteins, mitofilin, porin and capillarity than (-)-epicatechin alone.	Catechin	19-34	inner membrane protein, mitochondrial	Mus musculus	125-134
21812644-2	2011	We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver.	Catechin	49-57	glucose-6-phosphatase, catalytic	Mus musculus	141-162
21812644-2	2011	We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver.	Catechin	49-57	glucose-6-phosphatase, catalytic	Mus musculus	164-170
21812644-2	2011	We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver.	Catechin	49-57	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	176-209
21827489-3	2011	The inhibitive effect of (+-)-catechin on JNK/c-Jun activation was investigated.	Catechin	30-38	mitogen-activated protein kinase 8	Homo sapiens	42-45
21812644-2	2011	We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver.	Catechin	49-57	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	211-216
21827489-3	2011	The inhibitive effect of (+-)-catechin on JNK/c-Jun activation was investigated.	Catechin	30-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-51
21763406-0	2011	Epicatechin attenuates doxorubicin-induced brain toxicity: critical role of TNF-alpha, iNOS and NF-kappaB.	Catechin	0-11	tumor necrosis factor	Rattus norvegicus	76-85
21827489-8	2011	Moreover (+-)-catechin decreased JNK/c-Jun phosphorylation which was increased by MPP(+).	Catechin	14-22	mitogen-activated protein kinase 8	Homo sapiens	33-36
21827489-8	2011	Moreover (+-)-catechin decreased JNK/c-Jun phosphorylation which was increased by MPP(+).	Catechin	14-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
21827489-10	2011	Antioxidative stress and inhibition of the JNK/c-Jun signalling pathway might have been involved in the neuroprotective mechanisms of catechin against MPP(+) cytotoxicity in SH-SY5Y cells.	Catechin	134-142	mitogen-activated protein kinase 8	Homo sapiens	43-46
21827489-10	2011	Antioxidative stress and inhibition of the JNK/c-Jun signalling pathway might have been involved in the neuroprotective mechanisms of catechin against MPP(+) cytotoxicity in SH-SY5Y cells.	Catechin	134-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-52
21641774-0	2011	Tea catechins prevent contractile dysfunction in unloaded murine soleus muscle: a pilot study.	Catechin	4-13	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
21641774-3	2011	METHODS: Ten-week-old male BALB/c mice were fed a purified control diet or a diet containing 0.5% tea catechins for 14 d. Thereafter, the mice were subjected to continuous tail suspension for 10 d. On the final day, muscle mass, contractile force production, antioxidant potential, and carbonylated protein levels were evaluated.	Catechin	102-111	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	98-101
21641774-5	2011	Intake of tea catechins significantly inhibited the unloading-induced decrease in force in isolated soleus muscle by 19% compared with the control group, although tea catechins did not affect muscle weight.	Catechin	14-23	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	10-13
21641774-5	2011	Intake of tea catechins significantly inhibited the unloading-induced decrease in force in isolated soleus muscle by 19% compared with the control group, although tea catechins did not affect muscle weight.	Catechin	167-176	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	163-166
21641774-6	2011	In addition, intake of tea catechins suppressed the decrease in antioxidant potential and the increase in carbonyl myofibrillar protein.	Catechin	27-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	23-26
21641774-7	2011	CONCLUSION: Ingestion of tea catechins minimized contractile dysfunction in skeletal muscle and muscle atrophy in unloaded muscle.	Catechin	29-38	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	25-28
21641774-8	2011	This effect might be partly due to the lower oxidative modification of myofibrillar protein through the antioxidant activity of tea catechins.	Catechin	132-141	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	128-131
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Catechin	43-51	tumor necrosis factor	Mus musculus	247-256
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Catechin	43-51	interleukin 1 beta	Mus musculus	258-266
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Catechin	43-51	interleukin 6	Mus musculus	272-276
21617900-5	2011	Three-m/o ATX mice were treated with the cardio-protective polyphenol catechin for 9 months.	Catechin	70-78	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	10-13
21763406-0	2011	Epicatechin attenuates doxorubicin-induced brain toxicity: critical role of TNF-alpha, iNOS and NF-kappaB.	Catechin	0-11	nitric oxide synthase 2	Rattus norvegicus	87-91
21763406-3	2011	The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappaB expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only.	Catechin	41-52	tumor necrosis factor	Rattus norvegicus	126-135
21763406-3	2011	The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappaB expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only.	Catechin	41-52	nitric oxide synthase 2	Rattus norvegicus	137-141
21763406-3	2011	The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappaB expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only.	Catechin	41-52	tumor necrosis factor	Rattus norvegicus	193-202
21763406-4	2011	Thus, our study revealed that epicatechin can be used for the treatment of neuroinflammation and also for preventing the development of neurodegenerative disease during antineoplastic therapy because of its protective role in attenuation of neurotoxic pro-inflammatory mediators including TNF-alpha, NF-kappaB, and iNOS.	Catechin	30-41	tumor necrosis factor	Rattus norvegicus	289-298
21763406-4	2011	Thus, our study revealed that epicatechin can be used for the treatment of neuroinflammation and also for preventing the development of neurodegenerative disease during antineoplastic therapy because of its protective role in attenuation of neurotoxic pro-inflammatory mediators including TNF-alpha, NF-kappaB, and iNOS.	Catechin	30-41	nitric oxide synthase 2	Rattus norvegicus	315-319
21624470-4	2011	Plasma levels of unchanged tea catechins in humans are mostly in the sub-muM or nM concentration range, which is much lower than the effective concentrations determined in most in vitro studies.	Catechin	31-40	latexin	Homo sapiens	73-76
21525262-5	2011	Epicatechin treatment caused changes in diabetic mice that are associated with a healthier and longer lifespan, including improved skeletal muscle stress output, reduced systematic inflammation markers and serum LDL cholesterol, increased hepatic antioxidant glutathione concentration and total superoxide dismutase activity, decreased circulating insulin-like growth factor-1 (from 303 +- 21 mg/L in the diabetic control group to 189 +- 21 mg/L in the epicatechin-treated group), and improved AMP-activated protein kinase-alpha activity in the liver and skeletal muscle.	Catechin	0-11	insulin-like growth factor 1	Mus musculus	348-376
21412691-4	2011	With a few exceptions, the vast majority of these synthetic protocols involve the formation of the interflavanyl bond by acid/Lewis acid activation at C-4 of a flavan-3,4-diol or its equivalent, and subsequent trapping of the incipient C-4 carbocation by the nucleophilic centers of a flavan-3-ol (catechin).	Catechin	298-306	complement C4A (Rodgers blood group)	Homo sapiens	236-239
21332948-2	2011	Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively.	Catechin	13-21	carbonic anhydrase 1	Homo sapiens	110-115
21332948-2	2011	Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively.	Catechin	13-21	carbonic anhydrase 2	Homo sapiens	145-151
21352821-5	2011	Catechin prevented CYP2E1 induction by ethanol.	Catechin	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	19-25
21352821-7	2011	All the agents, except catechin, tended to reduce the expression of SOD2 induced by ethanol.	Catechin	23-31	superoxide dismutase 2	Homo sapiens	68-72
21457417-2	2011	METHODS AND RESULTS: Two bacterial strains, rK3 and aK2, were isolated from an epicatechin-converting human faecal suspension.	Catechin	79-90	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	44-47
21457417-2	2011	METHODS AND RESULTS: Two bacterial strains, rK3 and aK2, were isolated from an epicatechin-converting human faecal suspension.	Catechin	79-90	adenylate kinase 2	Homo sapiens	52-55
21457417-5	2011	Eggerthella lenta rK3 reductively cleaved the heterocyclic C-ring of both --epicatechin and +-catechin giving rise to 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol.	Catechin	74-87	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	18-21
21457417-5	2011	Eggerthella lenta rK3 reductively cleaved the heterocyclic C-ring of both --epicatechin and +-catechin giving rise to 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol.	Catechin	92-102	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	18-21
21694670-3	2011	The results showed that gallic acid, catechin, and epicatechin significantly inhibited pancreatic cholesterol esterase in a concentration-dependent manner.	Catechin	37-45	carboxyl ester lipase	Homo sapiens	87-118
21694670-3	2011	The results showed that gallic acid, catechin, and epicatechin significantly inhibited pancreatic cholesterol esterase in a concentration-dependent manner.	Catechin	51-62	carboxyl ester lipase	Homo sapiens	87-118
20936888-0	2011	Catechin inhibits adhesion and migration of peripheral blood B cells by blocking CD11b.	Catechin	0-8	integrin subunit alpha M	Homo sapiens	81-86
20683709-2	2011	Catechin increased alkaline phosphatase activity, calcium deposition, and mRNA expression of Runx2 and osteocalcin.	Catechin	0-8	RUNX family transcription factor 2	Homo sapiens	93-98
21405989-7	2011	Catechin exerted a slight but significant IKKb inhibition, in contrast to epicatechin, which was ineffective.	Catechin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	42-46
20683709-0	2011	Catechin stimulates osteogenesis by enhancing PP2A activity in human mesenchymal stem cells.	Catechin	0-8	protein phosphatase 2 phosphatase activator	Homo sapiens	46-50
20683709-2	2011	Catechin increased alkaline phosphatase activity, calcium deposition, and mRNA expression of Runx2 and osteocalcin.	Catechin	0-8	bone gamma-carboxyglutamate protein	Homo sapiens	103-114
20683709-7	2011	Primary hMSCs were then applied for confirming the osteogenic effects of catechin, which increased alkaline phosphatase activity, calcium deposition, and mRNA expression of Runx2 and osteocalcin.	Catechin	73-81	RUNX family transcription factor 2	Homo sapiens	173-178
20683709-7	2011	Primary hMSCs were then applied for confirming the osteogenic effects of catechin, which increased alkaline phosphatase activity, calcium deposition, and mRNA expression of Runx2 and osteocalcin.	Catechin	73-81	bone gamma-carboxyglutamate protein	Homo sapiens	183-194
20683709-8	2011	We further found the extracellular signal-regulated kinase (ERK) pathway was downregulated upon stimulation with catechin.	Catechin	113-121	mitogen-activated protein kinase 1	Homo sapiens	21-58
20683709-8	2011	We further found the extracellular signal-regulated kinase (ERK) pathway was downregulated upon stimulation with catechin.	Catechin	113-121	mitogen-activated protein kinase 1	Homo sapiens	60-63
20683709-9	2011	Catechin increased the level and activity of protein phosphatases 2A (PP2A) that dephosphorylates ERK kinase (MEK) and ERK.	Catechin	0-8	protein phosphatase 2 phosphatase activator	Homo sapiens	70-74
20683709-9	2011	Catechin increased the level and activity of protein phosphatases 2A (PP2A) that dephosphorylates ERK kinase (MEK) and ERK.	Catechin	0-8	mitogen-activated protein kinase 1	Homo sapiens	98-101
20683709-9	2011	Catechin increased the level and activity of protein phosphatases 2A (PP2A) that dephosphorylates ERK kinase (MEK) and ERK.	Catechin	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	110-113
20683709-9	2011	Catechin increased the level and activity of protein phosphatases 2A (PP2A) that dephosphorylates ERK kinase (MEK) and ERK.	Catechin	0-8	mitogen-activated protein kinase 1	Homo sapiens	119-122
20683709-10	2011	Further, PP2A inhibitor, okadaic acid, abolished the effect of catechin-mediated inactivation of ERK and stimulation of osteogenesis.	Catechin	63-71	protein phosphatase 2 phosphatase activator	Homo sapiens	9-13
20683709-10	2011	Further, PP2A inhibitor, okadaic acid, abolished the effect of catechin-mediated inactivation of ERK and stimulation of osteogenesis.	Catechin	63-71	mitogen-activated protein kinase 1	Homo sapiens	97-100
20683709-13	2011	CONCLUSIONS: These studies propose catechin enhanced osteogenesis by increasing the PP2A level that inhibits the MEK and ERK signaling in hMSCs.	Catechin	35-43	protein phosphatase 2 phosphatase activator	Homo sapiens	84-88
20683709-13	2011	CONCLUSIONS: These studies propose catechin enhanced osteogenesis by increasing the PP2A level that inhibits the MEK and ERK signaling in hMSCs.	Catechin	35-43	mitogen-activated protein kinase kinase 7	Homo sapiens	113-116
20683709-13	2011	CONCLUSIONS: These studies propose catechin enhanced osteogenesis by increasing the PP2A level that inhibits the MEK and ERK signaling in hMSCs.	Catechin	35-43	mitogen-activated protein kinase 1	Homo sapiens	121-124
20977430-8	2011	When the isolated polyphenols were tested, at the concentrations found in 10(-2) g/l RWPs, only epicatechin prevented endothelial dysfunction and all biochemical changes induced by ET-1 in the vascular wall.	Catechin	96-107	endothelin 1	Rattus norvegicus	181-185
21551947-2	2011	We previously reported that EGCG and a catechin-rich green tea beverage modulated the gene expression of gluconeogenic enzymes, glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), in the mouse liver.	Catechin	39-47	glucose-6-phosphatase, catalytic	Mus musculus	128-149
21551947-2	2011	We previously reported that EGCG and a catechin-rich green tea beverage modulated the gene expression of gluconeogenic enzymes, glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), in the mouse liver.	Catechin	39-47	glucose-6-phosphatase, catalytic	Mus musculus	151-157
21551947-2	2011	We previously reported that EGCG and a catechin-rich green tea beverage modulated the gene expression of gluconeogenic enzymes, glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), in the mouse liver.	Catechin	39-47	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	163-196
21551947-2	2011	We previously reported that EGCG and a catechin-rich green tea beverage modulated the gene expression of gluconeogenic enzymes, glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), in the mouse liver.	Catechin	39-47	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	198-203
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	Catechin	13-22	tumor necrosis factor	Homo sapiens	53-61
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	Catechin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	Catechin	13-22	proline rich acidic protein 1	Homo sapiens	187-190
20725062-3	2011	Epigallocatechin-3-gallate (EGCG: the most bioactive catechin in green tea) inhibits catechol-O-methyltransferase, an enzyme contributing to the degradation of catecholamines.	Catechin	8-16	catechol-O-methyltransferase	Homo sapiens	85-113
21186270-2	2011	We hypothesized that a chronic treatment with the polyphenol catechin would prevent endothelial dysfunction, maintain CBF responses, and protect learning abilities in atherosclerotic (ATX) mice.	Catechin	61-69	diencephalon/mesencephalon homeobox 1	Mus musculus	184-187
21186270-10	2011	Catechin 1) reduced cerebral superoxide staining (P &lt; 0.05) in ATX mice, 2) restored endothelial function by reducing myogenic tone, improving ACh- and FMD and restoring the sensitivity to nitric oxide synthase inhibition (P &lt; 0.05), 3) increased the changes in CBF during stimulation but not basal CBF, and 4) prevented the decline in learning abilities (P &lt; 0.05).	Catechin	0-8	diencephalon/mesencephalon homeobox 1	Mus musculus	66-69
21186270-11	2011	In conclusion, catechin treatment of ATX mice prevents cerebrovascular dysfunctions and the associated decline in learning capacities.	Catechin	15-23	diencephalon/mesencephalon homeobox 1	Mus musculus	37-40
21302360-0	2011	Comparison of a pair of synthetic tea-catechin-derived epimers: synthesis, antifolate activity, and tyrosinase-mediated activation in melanoma.	Catechin	38-46	tyrosinase	Homo sapiens	100-110
21136036-0	2011	Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected].	Catechin	0-11	nerve growth factor	Rattus norvegicus	19-42
21136036-0	2011	Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected].	Catechin	0-11	nerve growth factor receptor	Rattus norvegicus	105-108
21272567-0	2011	Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.	Catechin	42-51	taste 2 receptor member 39	Homo sapiens	111-119
21272567-5	2011	The response of hTAS2R39-expressing cells to ECg was the strongest among the tested catechins, followed by EGCg.	Catechin	84-93	taste 2 receptor member 39	Homo sapiens	16-24
21272567-8	2011	Our results suggest the participation of hTAS2R39 in the detection of catechins in humans, indicating the possibility that bitterness of tea catechins can be evaluated by using cells expressing hTAS2R39.	Catechin	70-79	taste 2 receptor member 39	Homo sapiens	41-49
21272567-8	2011	Our results suggest the participation of hTAS2R39 in the detection of catechins in humans, indicating the possibility that bitterness of tea catechins can be evaluated by using cells expressing hTAS2R39.	Catechin	141-150	taste 2 receptor member 39	Homo sapiens	41-49
21235242-0	2011	Extract of lotus leaf ( Nelumbo nucifera ) and its active constituent catechin with insulin secretagogue activity.	Catechin	70-78	insulin	Homo sapiens	84-91
21235242-9	2011	Furthermore, the in vitro and in vivo effects of the active constituents of NNE, quercetin, and catechin, on glucose-induced insulin secretion and blood glucose regulation were evaluated.	Catechin	96-104	insulin	Homo sapiens	125-132
21235242-10	2011	Quercetin did not affect insulin secretion, but catechin significantly and dose-dependently enhanced insulin secretion.	Catechin	48-56	insulin	Homo sapiens	101-108
21235242-12	2011	These findings suggest that NNE and its active constituent catechin are useful in the control of hyperglycemia in non-insulin-dependent diabetes mellitus through their action as insulin secretagogues.	Catechin	59-67	enolase 1, alpha non-neuron	Mus musculus	28-31
21235242-12	2011	These findings suggest that NNE and its active constituent catechin are useful in the control of hyperglycemia in non-insulin-dependent diabetes mellitus through their action as insulin secretagogues.	Catechin	59-67	insulin	Homo sapiens	118-125
21204551-0	2011	Chemoselective C-4 aerobic oxidation of catechin derivatives catalyzed by the Trametes villosa laccase/1-hydroxybenzotriazole system: synthetic and mechanistic aspects.	Catechin	40-48	complement C4A (Rodgers blood group)	Homo sapiens	15-18
21204551-4	2011	A remarkable and unexpected result for the laccase/HBT oxidative system has been the chemoselective insertion of the oxygen atom into the C-4-H bond of catechin derivatives.	Catechin	152-160	complement C4A (Rodgers blood group)	Homo sapiens	138-141
20718051-7	2011	Galloylated catechins and pyrogallol-type catechins exhibited higher binding affinities for HSA than non-galloylated and catechol-type catechins, respectively.	Catechin	12-21	albumin	Homo sapiens	92-95
20718051-7	2011	Galloylated catechins and pyrogallol-type catechins exhibited higher binding affinities for HSA than non-galloylated and catechol-type catechins, respectively.	Catechin	42-51	albumin	Homo sapiens	92-95
20718051-7	2011	Galloylated catechins and pyrogallol-type catechins exhibited higher binding affinities for HSA than non-galloylated and catechol-type catechins, respectively.	Catechin	42-51	albumin	Homo sapiens	92-95
21821919-1	2011	The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins.	Catechin	143-152	CXADR pseudogene 1	Homo sapiens	37-40
21047785-7	2011	The reduced activity was due to nitration of the protein because selective scavenging of peroxynitrite with epicatechin impaired OASA1 nitration and the concomitant inhibition of OASTL activity.	Catechin	108-119	O-acetylserine (thiol) lyase (OAS-TL) 	Arabidopsis thaliana	129-134
21047785-7	2011	The reduced activity was due to nitration of the protein because selective scavenging of peroxynitrite with epicatechin impaired OASA1 nitration and the concomitant inhibition of OASTL activity.	Catechin	108-119	O-acetylserine (thiol) lyase (OAS-TL) 	Arabidopsis thaliana	179-184
21597194-5	2011	Although catechins and CQA were oxidized by PPO, some catechins seemed to be non-enzymatically oxidized by CQA quinone.	Catechin	9-18	polyphenol oxidase, chloroplastic	Malus domestica	44-47
21821933-0	2011	Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins.	Catechin	106-115	matrix metallopeptidase 7	Homo sapiens	49-75
21821933-0	2011	Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins.	Catechin	106-115	matrix metallopeptidase 7	Homo sapiens	77-82
21821933-1	2011	Green tea catechins inhibit human matrix metalloproteinase 7 (MMP-7) activity non-competitively, and the galloyl group is essential for potent inhibition (Oneda et al., J.	Catechin	10-19	matrix metallopeptidase 7	Homo sapiens	34-60
21821933-1	2011	Green tea catechins inhibit human matrix metalloproteinase 7 (MMP-7) activity non-competitively, and the galloyl group is essential for potent inhibition (Oneda et al., J.	Catechin	10-19	matrix metallopeptidase 7	Homo sapiens	62-67
22145036-10	2011	While the content of flavan-3-ols (catechin, epi-catechin and epi-gallocatechin) was found to be increased in FLS silenced lines.	Catechin	35-43	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	110-113
20583320-9	2011	The ethoxyresorufin O-deethylation (CYP1A1) activity was moderately inhibited by (+)-catechin, while little effect was observed by (-)-epicatechin.	Catechin	81-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
20583320-9	2011	The ethoxyresorufin O-deethylation (CYP1A1) activity was moderately inhibited by (+)-catechin, while little effect was observed by (-)-epicatechin.	Catechin	131-146	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
21207318-6	2011	EGCG, myricetin, and catechin decreased MCT1 mRNA expression, while chrysin increased it; quercetin, rutin, and xanthohumol had no effect.	Catechin	21-29	solute carrier family 16 member 1	Homo sapiens	40-44
22144918-0	2011	Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors.	Catechin	45-53	adiponectin, C1Q and collagen domain containing	Homo sapiens	88-99
22144918-4	2011	OBJECTIVE: The objective of this randomized controlled trial (RCT) was to assess whether the consumption of catechin-enriched GT affects serum adiponectin levels and cardiovascular disease (CVD) risk factors among apparently healthy subjects.	Catechin	108-116	adiponectin, C1Q and collagen domain containing	Homo sapiens	143-154
21207318-2	2011	Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin.	Catechin	259-270	latexin	Homo sapiens	32-35
21207318-5	2011	Moreover, catechin (1 muM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 muM) decreased it.	Catechin	10-18	latexin	Homo sapiens	22-25
21207318-5	2011	Moreover, catechin (1 muM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 muM) decreased it.	Catechin	10-18	latexin	Homo sapiens	135-138
21207318-5	2011	Moreover, catechin (1 muM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 muM) decreased it.	Catechin	121-129	latexin	Homo sapiens	22-25
22145036-10	2011	While the content of flavan-3-ols (catechin, epi-catechin and epi-gallocatechin) was found to be increased in FLS silenced lines.	Catechin	45-57	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	110-113
22022384-0	2011	Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition.	Catechin	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
20883750-0	2010	Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK.	Catechin	0-11	Eph receptor B1	Rattus norvegicus	107-110
21673994-9	2011	Supplementation with catechin ameliorated the alcohol-induced liver injury by downregulating the endotoxin-mediated activation of initial signalling molecule NF-kappaB and further going downstream the signalling cascade including tumor necrosis factor-alpha, nitric oxide and reactive oxygen species and by enhancing the antioxidant profile.	Catechin	21-29	tumor necrosis factor	Rattus norvegicus	230-257
21167021-0	2010	Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis.	Catechin	0-8	tumor protein p53	Homo sapiens	56-60
20883750-8	2010	EC inhibited activation of JNK, ERK, cytochrome-c and caspase-3 by cisplatin.	Catechin	0-2	mitogen-activated protein kinase 8	Rattus norvegicus	27-30
20883750-8	2010	EC inhibited activation of JNK, ERK, cytochrome-c and caspase-3 by cisplatin.	Catechin	0-2	Eph receptor B1	Rattus norvegicus	32-35
20883750-8	2010	EC inhibited activation of JNK, ERK, cytochrome-c and caspase-3 by cisplatin.	Catechin	0-2	caspase 3	Rattus norvegicus	54-63
20837083-8	2010	EC administration to leukemic rats induced a significant increase in the level of Annexin V-positive leukemic cells, but the level of non-leukemic Annexin V-positive cells remained unchanged in comparison to control.	Catechin	0-2	annexin A5	Rattus norvegicus	82-91
20691749-3	2010	Total phenolic content found in methanol extracts of SM1-SM5 ranged from 739.36 +- 1.59 to 1116.13 +- 7.30 gallic acid equivalents mg/100g extract and total flavonoid content from 1991.29 +- 6.32 to 3954.20 +- 6.06 catechin equivalents mg/100 g extract.	Catechin	215-223	SM1	Homo sapiens	53-56
21776468-1	2010	In this study, we investigated the effects of tea catechins on the translocation of glucose transporter (GLUT) 4 in 3T3-L1 adipocytes.	Catechin	50-59	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	105-109
21776468-5	2010	When the cells were treated with 50 muM catechins for 30 min, EC and EGC promoted GLUT4 translocation, whereas Cg and EGCg decreased the insulin-induced translocation in the cells.	Catechin	40-49	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	82-87
21776468-5	2010	When the cells were treated with 50 muM catechins for 30 min, EC and EGC promoted GLUT4 translocation, whereas Cg and EGCg decreased the insulin-induced translocation in the cells.	Catechin	62-64	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	82-87
21776468-6	2010	EC and EGC increased phosphorylation of PKClambda/zeta without phosphorylation of insulin receptor (IR) and Akt.	Catechin	0-2	protein kinase C, iota	Mus musculus	40-49
21776468-9	2010	Therefore, EC and EGC promote the translocation of GLUT4 through activation of PI3K, and Cg and EGCg inhibit insulin-induced translocation of GLUT4 by the insulin signaling pathway in 3T3-L1 cells.	Catechin	11-13	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	51-56
20442725-0	2010	The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.	Catechin	13-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
20442725-0	2010	The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.	Catechin	13-28	heme oxygenase 1	Mus musculus	69-72
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	0-11	Rous sarcoma oncogene	Mus musculus	71-74
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	0-11	thymoma viral proto-oncogene 1	Mus musculus	76-79
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	85-97
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	0-11	DNA fragmentation factor, beta subunit	Mus musculus	181-204
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	16-27	Rous sarcoma oncogene	Mus musculus	71-74
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	16-27	thymoma viral proto-oncogene 1	Mus musculus	76-79
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	16-27	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	85-97
20833967-11	2010	Epicatechin and epicatechin + nor-BNI increased the phosphorylation of Src, Akt, and IkappaBalpha, while simultaneously decreasing the expression of c-Jun NH(2)-terminal kinase and caspase-activated DNase.	Catechin	16-27	DNA fragmentation factor, beta subunit	Mus musculus	181-204
21495460-8	2010	In the presence of an antioxidant (catechin) the radical cation APH*+ forms to a molar ratio APH-ammonium persulfate of 1:1, in weak alkaline environment.	Catechin	35-43	acylaminoacyl-peptide hydrolase	Homo sapiens	64-67
21966103-0	2010	Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway.	Catechin	19-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	80-83
21966103-1	2010	Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity.	Catechin	173-181	galanin and GMAP prepropeptide	Rattus norvegicus	192-196
21966103-6	2010	We found that increases in the liver enzyme activity and decrease in antioxidant enzyme activity by d-GalN were significantly restricted by oral pretreatment with catechin.	Catechin	163-171	galanin and GMAP prepropeptide	Rattus norvegicus	102-106
21966103-7	2010	Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.	Catechin	203-211	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
21966103-7	2010	Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.	Catechin	203-211	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
21966103-7	2010	Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.	Catechin	203-211	BCL2, apoptosis regulator	Rattus norvegicus	97-102
21966103-7	2010	Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.	Catechin	203-211	galanin and GMAP prepropeptide	Rattus norvegicus	133-137
20455202-4	2010	The concentration of EGCG that decreased insulin-stimulated glucose uptake by 50-60% was approximately 5-10 microM for a period of 2 h. At 10 microM, EGCG and gallic acid were more effective than (-)-epicatechin, (-)-epigallocatechin, and (-)-epicatechin 3-gallate.	Catechin	196-211	insulin	Oryctolagus cuniculus	41-48
21495460-8	2010	In the presence of an antioxidant (catechin) the radical cation APH*+ forms to a molar ratio APH-ammonium persulfate of 1:1, in weak alkaline environment.	Catechin	35-43	acylaminoacyl-peptide hydrolase	Homo sapiens	93-96
20682974-2	2010	The main aim of this study was to examine the effect of green tea catechins (namely, (-)-epigallocatechin-3-gallate; EGCG) on TROP-2 expression.	Catechin	66-75	tumor associated calcium signal transducer 2	Homo sapiens	126-132
20692173-5	2010	The epicatechin based polyphenols 1 and 2 also showed inhibition of angiogenin-induced angiogenesis, as determined by chorioallantoic membrane (CAM) assay.	Catechin	4-15	angiogenin	Homo sapiens	68-78
20541420-0	2010	Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson"s disease.	Catechin	87-95	nitric oxide synthase 2, inducible	Mus musculus	14-45
20471964-0	2010	Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).	Catechin	10-19	ryanodine receptor 1	Homo sapiens	46-71
20471964-0	2010	Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).	Catechin	10-19	ryanodine receptor 1	Homo sapiens	73-77
20471964-6	2010	Four related catechins, EGCG, ECG, EGC ((-)-epigallocatechin) and EC ((-)-epicatechin) showed a rank order of activity toward RyR1 (EGCG&gt;ECG&gt;&gt;EGC&gt;&gt;&gt;EC).	Catechin	13-22	ryanodine receptor 1	Homo sapiens	126-130
20471964-6	2010	Four related catechins, EGCG, ECG, EGC ((-)-epigallocatechin) and EC ((-)-epicatechin) showed a rank order of activity toward RyR1 (EGCG&gt;ECG&gt;&gt;EGC&gt;&gt;&gt;EC).	Catechin	70-85	ryanodine receptor 1	Homo sapiens	126-130
20471964-9	2010	The results identify RyR1 as a sensitive target for the major tea catechins EGCG and ECG, and this interaction is likely to contribute to their observed biological activities.	Catechin	66-75	ryanodine receptor 1	Homo sapiens	21-25
20877565-0	2010	Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I.	Catechin	10-18	DExD/H-box helicase 58	Homo sapiens	103-108
20957092-5	2010	It was found that epicatechin and catechin exhibited high affinity with both enzymes, even though POD and PPO have different binding pockets regarding the size and the key amino acids involved in binding.	Catechin	18-29	protoporphyrinogen oxidase	Homo sapiens	106-109
20957092-5	2010	It was found that epicatechin and catechin exhibited high affinity with both enzymes, even though POD and PPO have different binding pockets regarding the size and the key amino acids involved in binding.	Catechin	21-29	protoporphyrinogen oxidase	Homo sapiens	106-109
20450880-4	2010	Flavones and flavonols suppressed the TCDD-induced nuclear translocation of the AhR and dissociation of its partner proteins, heat shock protein 90 and X-associated protein 2, whereas flavanones and catechins did not.	Catechin	199-208	aryl-hydrocarbon receptor	Mus musculus	80-83
20450880-8	2010	Flavanones and catechins suppressed the TCDD-induced phosphorylation of ERK1/2.	Catechin	15-24	mitogen-activated protein kinase 3	Mus musculus	72-78
20450880-9	2010	The inhibition of MEK/ERK phosphorylation is one of the mechanisms by which flavanones and catechins suppress the AhR-mediated signal transduction in Hepa-1c1c7 cells.	Catechin	91-100	mitogen-activated protein kinase 1	Mus musculus	22-25
20450880-9	2010	The inhibition of MEK/ERK phosphorylation is one of the mechanisms by which flavanones and catechins suppress the AhR-mediated signal transduction in Hepa-1c1c7 cells.	Catechin	91-100	aryl-hydrocarbon receptor	Mus musculus	114-117
21057643-7	2010	In addition, activation of signature cell death genes such as acd2 and cad1 post catechin treatment in A. thaliana ascertains the phytotoxic nature of catechin.	Catechin	81-89	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	71-75
21057643-7	2010	In addition, activation of signature cell death genes such as acd2 and cad1 post catechin treatment in A. thaliana ascertains the phytotoxic nature of catechin.	Catechin	151-159	accelerated cell death 2 (ACD2)	Arabidopsis thaliana	62-66
21057643-7	2010	In addition, activation of signature cell death genes such as acd2 and cad1 post catechin treatment in A. thaliana ascertains the phytotoxic nature of catechin.	Catechin	151-159	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	71-75
20505358-9	2010	Our results showed that (+-)-catechin treatment to A. thaliana plants resulted in activation of signature cell death genes such as accelerated cell death (acd2) and constitutively activated cell death 1 (cad1).	Catechin	24-37	accelerated cell death 2 (ACD2)	Arabidopsis thaliana	155-159
20710064-5	2010	RESULTS: Procyanidin B1 (PB1), a dimer of (-)-epicatechin and (+)-catechin, purified from Cinnamomi cortex, inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with 50% effective concentrations of 29 and 15 microM, respectively.	Catechin	42-57	submaxillary gland androgen regulated protein 3A	Homo sapiens	25-28
20710064-5	2010	RESULTS: Procyanidin B1 (PB1), a dimer of (-)-epicatechin and (+)-catechin, purified from Cinnamomi cortex, inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with 50% effective concentrations of 29 and 15 microM, respectively.	Catechin	62-74	submaxillary gland androgen regulated protein 3A	Homo sapiens	25-28
20552703-6	2010	Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin.	Catechin	241-249	catalase	Homo sapiens	35-38
20552703-6	2010	Moreover, it is also proposed that Cat-Vit A pigments arise from the cycloaddition of pyruvic acid to an anthocyanin moiety of a flavanol-anthocyanin adduct rather than by direct nucleophilic attack of a vitisin A on the carbocation C(4) of catechin.	Catechin	241-249	vitrin	Homo sapiens	39-42
20596890-1	2010	Tea catechin is one of the compounds that are closely related to obesity and insulin sensitivity.	Catechin	4-12	insulin	Homo sapiens	77-84
20514403-5	2010	Furthermore, the administration of DOX in combination with ECG or EGCG markedly enhanced intracellular DOX accumulation, which implies that the catechins inhibited P-glycoprotein (P-gp) efflux pump activity.	Catechin	144-153	phosphoglycolate phosphatase	Mus musculus	164-178
20514403-10	2010	The chemosensitizing effect of catechins may occur directly or indirectly by reversal of multidrug resistance, involving the suppression of MDR1 expression, or by enhancement of intracellular DOX accumulation, involving inhibition of P-gp function.	Catechin	31-40	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	140-144
20514403-5	2010	Furthermore, the administration of DOX in combination with ECG or EGCG markedly enhanced intracellular DOX accumulation, which implies that the catechins inhibited P-glycoprotein (P-gp) efflux pump activity.	Catechin	144-153	phosphoglycolate phosphatase	Mus musculus	180-184
20514403-10	2010	The chemosensitizing effect of catechins may occur directly or indirectly by reversal of multidrug resistance, involving the suppression of MDR1 expression, or by enhancement of intracellular DOX accumulation, involving inhibition of P-gp function.	Catechin	31-40	phosphoglycolate phosphatase	Mus musculus	234-238
19616927-0	2010	Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts.	Catechin	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	18-24
19616927-0	2010	Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts.	Catechin	0-9	oncostatin M	Homo sapiens	41-53
20622468-2	2010	Inclusion of catechin-rich green tea beverage (GTB) in the culture medium reduced the up-regulation of these genes as well as that of hepatocyte nuclear factor 4 alpha (HNF4alpha) gene.	Catechin	13-21	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	134-167
20229526-6	2010	Moreover, epigallocatechin (EGC), and to a lesser extent epicatechin, metabolites identified in the proanthocyanidin extract, suppressed IL-4-stimulated CCL26 secretion.	Catechin	57-68	interleukin 4	Homo sapiens	137-141
20229526-6	2010	Moreover, epigallocatechin (EGC), and to a lesser extent epicatechin, metabolites identified in the proanthocyanidin extract, suppressed IL-4-stimulated CCL26 secretion.	Catechin	57-68	C-C motif chemokine ligand 26	Homo sapiens	153-158
20382853-8	2010	In mice with established ATX, catechin (from 9 to 12 mo) reduced (P &lt; 0.05) by approximately 60% ROS without affecting plaque burden.	Catechin	30-38	diencephalon/mesencephalon homeobox 1	Mus musculus	25-28
20382853-9	2010	Notably, catechin worsened endothelial dysfunction and further increased leukocyte adhesion (P &lt; 0.05) in ATX mice.	Catechin	9-17	diencephalon/mesencephalon homeobox 1	Mus musculus	109-112
20382853-11	2010	On the other hand, in pre-ATX mice treated for 9 mo with catechin, plaque burden was reduced by 64% (P &lt; 0.05) and all vascular markers were normalized to the 3-mo-old values.	Catechin	57-65	diencephalon/mesencephalon homeobox 1	Mus musculus	26-29
20622468-2	2010	Inclusion of catechin-rich green tea beverage (GTB) in the culture medium reduced the up-regulation of these genes as well as that of hepatocyte nuclear factor 4 alpha (HNF4alpha) gene.	Catechin	13-21	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	169-178
20013883-8	2010	These results indicate that the most important structural element contributing to HSA binding of tea catechins is the galloyl group, followed by the number of hydroxyl groups on the B-ring and the galloyl group or the configuration at C-2.	Catechin	101-110	complement C2	Homo sapiens	235-238
20404222-0	2010	(-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways.	Catechin	0-15	nitric oxide synthase 3	Homo sapiens	47-80
20404222-1	2010	Recent reports indicate that (-)-epicatechin can exert cardioprotective actions, which may involve endothelial nitric oxide synthase (eNOS)-mediated nitric oxide production in endothelial cells.	Catechin	29-44	nitric oxide synthase 3	Homo sapiens	99-132
20404222-7	2010	(-)-Epicatechin induces eNOS uncoupling from caveolin-1 and its association with calmodulin-1, suggesting the involvement of intracellular calcium.	Catechin	0-15	caveolin 1	Homo sapiens	45-55
20404222-7	2010	(-)-Epicatechin induces eNOS uncoupling from caveolin-1 and its association with calmodulin-1, suggesting the involvement of intracellular calcium.	Catechin	0-15	calmodulin 1	Homo sapiens	81-93
20404222-11	2010	The inhibitory effects of the preincubation of cells with the calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 indicate that (-)-epicatechin-induced eNOS activation is at least partially mediated via the Ca(2+)/CaMKII pathway.	Catechin	132-147	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	62-92
20404222-11	2010	The inhibitory effects of the preincubation of cells with the calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 indicate that (-)-epicatechin-induced eNOS activation is at least partially mediated via the Ca(2+)/CaMKII pathway.	Catechin	132-147	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	94-100
20404222-11	2010	The inhibitory effects of the preincubation of cells with the calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 indicate that (-)-epicatechin-induced eNOS activation is at least partially mediated via the Ca(2+)/CaMKII pathway.	Catechin	132-147	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	218-224
20381572-4	2010	In the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups, there were statistically significant increases in CAT and SOD activities, while no statistically significant changes were observed in MDA, GST and GPx activities relative to the control.	Catechin	7-15	catalase	Rattus norvegicus	133-136
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Catechin	57-65	hematopoietic prostaglandin D synthase	Rattus norvegicus	163-166
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Catechin	57-65	catalase	Rattus norvegicus	220-223
20432242-11	2010	EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17beta-hydroxysteroid dehydrogenase (17beta-HSD).	Catechin	0-2	aldo-keto reductase family 1, member C12	Rattus norvegicus	102-137
20432242-11	2010	EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17beta-hydroxysteroid dehydrogenase (17beta-HSD).	Catechin	0-2	aldo-keto reductase family 1, member C12	Rattus norvegicus	139-149
20432242-11	2010	EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17beta-hydroxysteroid dehydrogenase (17beta-HSD).	Catechin	15-24	aldo-keto reductase family 1, member C12	Rattus norvegicus	102-137
20432242-11	2010	EC, one of the catechins increased the testosterone secretion by rat LCs via the enzyme activities of 17beta-hydroxysteroid dehydrogenase (17beta-HSD).	Catechin	15-24	aldo-keto reductase family 1, member C12	Rattus norvegicus	139-149
20230058-6	2010	Four compounds (emodin, emodin-8-O-beta-D-glucopyranoside, (+)-catechin, and (-)-epicatechin) isolated from EP were identified as ACC inhibitors.	Catechin	59-71	acetyl-CoA carboxylase alpha	Homo sapiens	130-133
20180920-7	2010	We also revealed that tt12 specifically accumulated glycosylated epicatechins, the putative transport substrates for TT12.	Catechin	65-77	MATE efflux family protein	Arabidopsis thaliana	22-26
20180920-7	2010	We also revealed that tt12 specifically accumulated glycosylated epicatechins, the putative transport substrates for TT12.	Catechin	65-77	MATE efflux family protein	Arabidopsis thaliana	117-121
20180920-9	2010	Given the cytosolic localization of functional GFP-TT19 proteins, our results suggest that TT19, which acts prior to TT12, functions in the cytosol to maintain the regular accumulation of PA precursors, such as epicatechin and glycosylated epicatechin, in the vacuole.	Catechin	211-222	glutathione S-transferase phi 12	Arabidopsis thaliana	51-55
20180920-9	2010	Given the cytosolic localization of functional GFP-TT19 proteins, our results suggest that TT19, which acts prior to TT12, functions in the cytosol to maintain the regular accumulation of PA precursors, such as epicatechin and glycosylated epicatechin, in the vacuole.	Catechin	211-222	glutathione S-transferase phi 12	Arabidopsis thaliana	91-95
20180920-9	2010	Given the cytosolic localization of functional GFP-TT19 proteins, our results suggest that TT19, which acts prior to TT12, functions in the cytosol to maintain the regular accumulation of PA precursors, such as epicatechin and glycosylated epicatechin, in the vacuole.	Catechin	211-222	MATE efflux family protein	Arabidopsis thaliana	117-121
20180920-9	2010	Given the cytosolic localization of functional GFP-TT19 proteins, our results suggest that TT19, which acts prior to TT12, functions in the cytosol to maintain the regular accumulation of PA precursors, such as epicatechin and glycosylated epicatechin, in the vacuole.	Catechin	240-251	glutathione S-transferase phi 12	Arabidopsis thaliana	91-95
20180920-9	2010	Given the cytosolic localization of functional GFP-TT19 proteins, our results suggest that TT19, which acts prior to TT12, functions in the cytosol to maintain the regular accumulation of PA precursors, such as epicatechin and glycosylated epicatechin, in the vacuole.	Catechin	240-251	MATE efflux family protein	Arabidopsis thaliana	117-121
20206613-3	2010	We found that one of the catechin conjugated with capric acid [(2R,3S)-3",4",5,7-tetrahydroxyflavan-3-yl decanoate; catechin-C10] was most potent to induce apoptosis in U937 cells.	Catechin	25-33	homeobox C10	Homo sapiens	125-128
20423994-2	2010	In this study, we show that IGFIR is constitutively activated in EFTs and that the major catechin derivative found in green tea, (-)-epigallocatechin gallate (EGCG), can inhibit cell proliferation and survival of EFT cells through the inhibition of IGFIR activity.	Catechin	89-97	insulin like growth factor 1 receptor	Homo sapiens	28-33
20423994-2	2010	In this study, we show that IGFIR is constitutively activated in EFTs and that the major catechin derivative found in green tea, (-)-epigallocatechin gallate (EGCG), can inhibit cell proliferation and survival of EFT cells through the inhibition of IGFIR activity.	Catechin	89-97	insulin like growth factor 1 receptor	Homo sapiens	249-254
20230058-6	2010	Four compounds (emodin, emodin-8-O-beta-D-glucopyranoside, (+)-catechin, and (-)-epicatechin) isolated from EP were identified as ACC inhibitors.	Catechin	77-92	acetyl-CoA carboxylase alpha	Homo sapiens	130-133
20093625-6	2010	Although (-)-epicatechin significantly reduced F(2)-isoprostane, superoxide, and endothelin-1 production (P&lt;0.05 versus control ApoE(-/-) mice), it had no significant effect on lesion size.	Catechin	9-24	endothelin 1	Mus musculus	81-93
20176036-3	2010	MAIN METHODS: Streptococci or PAMP-stimulated HDPF were treated with catechin, and then the expression and production of pro-inflammatory mediators were determined by RT-PCR and ELISA.	Catechin	69-77	adrenomedullin	Homo sapiens	30-34
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	Catechin	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	Catechin	141-150	adrenomedullin	Homo sapiens	102-106
20138891-2	2010	LAR1 from Vitis vinifera has been co-crystallized with or without NADPH and one of its natural products, (+)-catechin.	Catechin	105-117	leucoanthocyanidin reductase 1	Vitis vinifera	0-4
20018169-0	2010	(-)-Epicatechin enhances the chlorinating activity of human myeloperoxidase.	Catechin	0-15	myeloperoxidase	Homo sapiens	60-75
20056894-0	2010	Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT.	Catechin	10-18	solute carrier family 10 member 2	Homo sapiens	75-79
20056894-3	2010	The present studies were, therefore, designed to investigate the modulation of ASBT function and membrane expression by green tea catechins in human embryonic kidney HEK-293 cells stably transfected with ASBT-V5 fusion protein and intestinal Caco-2 monolayers.	Catechin	130-139	solute carrier family 10 member 2	Homo sapiens	79-83
20041424-4	2010	Pretreatment of cells with EC for 20 h prevented the enhanced cell damage and GPx and GR activities as well as the decrease in GSH induced by t-BOOH.	Catechin	27-29	glutathione-disulfide reductase	Homo sapiens	86-88
20041424-7	2010	A pretreatment for 2 h with EC did not reduce cell damage but partly recovered GSH, reduced ROS levels and muffled the increase of GPx and GR after exposure to t-BOOH.	Catechin	28-30	glutathione-disulfide reductase	Homo sapiens	139-141
20018169-5	2010	By affecting the chlorinating activity of myeloperoxidase (-)-epicatechin may participate in regulation of immune responses at inflammatory sites.	Catechin	58-73	myeloperoxidase	Homo sapiens	42-57
19157820-0	2010	A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the posttranscriptional level.	Catechin	70-79	nudix hydrolase 6	Homo sapiens	32-37
19157820-8	2010	These findings provide a novel mechanism for the suppression of the proliferative gene NUDT6 by green tea catechins in human colorectal cancer.	Catechin	106-115	nudix hydrolase 6	Homo sapiens	87-92
19157820-1	2010	The main aims of this study were to elucidate the effect of green tea catechins on Nudix-type motif 6 (NUDT6) suppression and to characterize NUDT6"s biological activity.	Catechin	70-79	nudix hydrolase 6	Homo sapiens	83-101
19157820-1	2010	The main aims of this study were to elucidate the effect of green tea catechins on Nudix-type motif 6 (NUDT6) suppression and to characterize NUDT6"s biological activity.	Catechin	70-79	nudix hydrolase 6	Homo sapiens	103-108
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	protein tyrosine kinase 2 beta	Homo sapiens	164-180
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-50
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	AKT serine/threonine kinase 1	Homo sapiens	187-190
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
20030899-0	2010	Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells.	Catechin	0-11	mitogen-activated protein kinase 1	Homo sapiens	228-231
20030899-2	2010	The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells.	Catechin	87-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-180
20030899-2	2010	The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells.	Catechin	87-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-186
20030899-2	2010	The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells.	Catechin	87-98	NFE2 like bZIP transcription factor 2	Homo sapiens	252-256
20030899-3	2010	Treatment of cells with 10 microm-epicatechin induced the NF-kappaB pathway in a time-dependent manner characterised by increased levels of IkappaB kinase (IKK) and phosphorylated inhibitor of kappaB subunit-alpha (p-IkappaBalpha) and proteolytic degradation of IkappaB, which was consistent with an up-regulation of the NF-kappaB-binding activity.	Catechin	33-45	NFKB inhibitor alpha	Homo sapiens	217-229
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	protein tyrosine kinase 2 beta	Homo sapiens	219-235
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	AKT serine/threonine kinase 1	Homo sapiens	242-245
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	mitogen-activated protein kinase 1	Homo sapiens	283-286
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	NFE2 like bZIP transcription factor 2	Homo sapiens	302-306
20030899-5	2010	Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction.	Catechin	14-25	mitogen-activated protein kinase 1	Homo sapiens	322-325
21228505-0	2010	Influence of the galloyl moiety in tea catechins on binding affinity for human serum albumin.	Catechin	39-48	albumin	Homo sapiens	79-92
20651464-0	2010	Preventive effects of C-2 epimeric isomers of tea catechins on mouse type I allergy.	Catechin	50-59	complement component 2 (within H-2S)	Mus musculus	22-25
21228505-2	2010	Recent research has indicated that catechins form complexes with human serum albumin (HSA) in blood, and differences in their binding affinity toward HSA are believed to modulate their bioavailability.	Catechin	35-44	albumin	Homo sapiens	71-84
20651464-6	2010	These results indicated that C-2 epimerization of tea catechins, which are produced during heat processing at high temperatures, would not be disadvantageous for preventive effects on type I allergy.	Catechin	54-63	complement component 2 (within H-2S)	Mus musculus	29-32
19839593-0	2009	Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.	Catechin	4-13	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	22-55
19861125-3	2009	In this study we tested (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of green tea, as an inhibitor of TTR amyloid formation.	Catechin	36-44	transthyretin	Homo sapiens	123-126
19815813-10	2010	Blocking tyrosine nitration of PI 3-kinase with epicatechin or NAC restored Akt phosphorylation, and inhibited vaso-obliteration at p12 and neovascularization at p17 comparable with FeTPPS.	Catechin	48-59	AKT serine/threonine kinase 1	Homo sapiens	76-79
19815813-10	2010	Blocking tyrosine nitration of PI 3-kinase with epicatechin or NAC restored Akt phosphorylation, and inhibited vaso-obliteration at p12 and neovascularization at p17 comparable with FeTPPS.	Catechin	48-59	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	162-165
19897346-5	2010	The epimers (+)-catechin and (-)-epicatechin exhibited negligible affinities for both CB1 and CB2.	Catechin	29-44	cannabinoid receptor 1	Homo sapiens	86-89
19897346-5	2010	The epimers (+)-catechin and (-)-epicatechin exhibited negligible affinities for both CB1 and CB2.	Catechin	29-44	cannabinoid receptor 2	Homo sapiens	94-97
19931438-12	2010	Catechin restored the altered Glucokinase, glucose-6 Phosphatase, Glycogen Synthase and Glycogen Phosphorylase levels to near normal.	Catechin	0-8	glucokinase	Rattus norvegicus	30-41
19931438-12	2010	Catechin restored the altered Glucokinase, glucose-6 Phosphatase, Glycogen Synthase and Glycogen Phosphorylase levels to near normal.	Catechin	0-8	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	43-64
19931438-12	2010	Catechin restored the altered Glucokinase, glucose-6 Phosphatase, Glycogen Synthase and Glycogen Phosphorylase levels to near normal.	Catechin	0-8	glycogen phosphorylase L	Rattus norvegicus	88-110
19931438-13	2010	GLUT4 mRNA and protein expression were enhanced after Catechin treatment.	Catechin	54-62	solute carrier family 2 member 4	Rattus norvegicus	0-5
19904937-0	2009	Tea catechins induce the conversion of preformed lysozyme amyloid fibrils to amorphous aggregates.	Catechin	4-13	lysozyme	Homo sapiens	49-57
19904937-5	2009	Results showed that tea catechins induced the conversion of lysozyme fibrils to amorphous aggregates and inhibited fibril-induced hemolysis.	Catechin	24-33	lysozyme	Homo sapiens	60-68
19632288-5	2009	All investigated compounds except for catechin and gallic acid inhibited P-gp activity in HK-2 cells, in the order of mangiferin&lt;norathyriol&lt;quercetin&lt;MSBE.	Catechin	38-46	phosphoglycolate phosphatase	Homo sapiens	73-77
19632288-3	2009	The effects of MSBE, mangiferin, norathyriol, catechin, quercetin and gallic acid on P-gp activity were tested by the rhodamine-123 accumulation as well as by the Calcein-AM assays.	Catechin	46-54	phosphoglycolate phosphatase	Homo sapiens	85-89
18821062-0	2009	Green tea catechins inhibit angiogenesis through suppression of STAT3 activation.	Catechin	10-19	signal transducer and activator of transcription 3	Homo sapiens	64-69
20101984-0	2009	[Investigation of interaction between catechin and bovine serum albumin by spectroscopic methods].	Catechin	38-46	albumin	Homo sapiens	58-71
20101984-1	2009	In the present work, the interaction of catechin with bovine serum albumin (BSA) under physiological condition was studied by fluorescence quenching spectra in combination with Fourier transform infrared (FTIR) spectroscopy.	Catechin	40-48	albumin	Homo sapiens	61-74
19668087-4	2009	Recent studies have demonstrated that tea catechin, especially (-)-epigallocatechin-3-gallate, inhibits the expression of these molecules by endothelial cells in response to stimulation with oxidized LDL or inflammatory cytokines and the expression of CD11b by monocytic leukocytes.	Catechin	42-50	integrin alpha M	Mus musculus	252-257
19668087-5	2009	An in vivo study using apolipoprotein E-deficient mice has demonstrated that tea catechin extracts prevent the development of atherosclerosis and that (-)-epigallocatechin-3-gallate effectively reduces the progression of accelerated atherosclerotic plaque formation induced by cuff injury.	Catechin	81-89	apolipoprotein E	Mus musculus	23-39
19666002-2	2009	Procyanidins (Pcy) are oligomeric and polymeric flavonoids formed by catechins and epicatechins monomers trigger apoptosis by activating TRAIL-death receptors in human colon adenocarcinoma SW480 cells.	Catechin	83-95	TNF superfamily member 10	Homo sapiens	137-142
19264308-9	2009	Catechin reduced vascular reactive oxygen species formation in the aorta and suppressed the expression of p22phox and p47phox NADPH oxidase subunits.	Catechin	0-8	cytochrome b-245 alpha chain	Rattus norvegicus	106-113
19406223-5	2009	By conducting a series of luciferase-based reporter assays, we revealed that the catechin mixture only up-regulates the p53 reporter.	Catechin	81-89	tumor protein p53	Homo sapiens	120-123
19723101-0	2009	Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2.	Catechin	10-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	94-99
19631328-8	2009	Especially in the MEP capillary, hydrophobic characteristics and pi-pi interactions with aromatic solutes were found and further improved to resolve an enantiomeric pair, catechin and epicatechin.	Catechin	171-179	neurolysin	Homo sapiens	18-21
19631328-8	2009	Especially in the MEP capillary, hydrophobic characteristics and pi-pi interactions with aromatic solutes were found and further improved to resolve an enantiomeric pair, catechin and epicatechin.	Catechin	184-195	neurolysin	Homo sapiens	18-21
19578793-2	2009	In the present study, we investigated whether (-)-epigallocatechin gallate (EGCG), the major polyphenol found in green tea, affects the induction of HSP27 in these cells and its mechanism, since it was previously reported that catechin, including EGCG, suppresses bone resorption.	Catechin	58-66	heat shock protein 1	Mus musculus	149-154
19383571-1	2009	The electrochemical properties of catechin at single-walled carbon nanotubes (SWNTs)-cetylramethylammonium bromide (CTAB) modified glassy carbon electrodes (GCE) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV).	Catechin	34-42	aminomethyltransferase	Homo sapiens	157-160
19176763-7	2009	Generally, EGCG was more effective than epicatechin, epicatechin gallate, and epigallocatechin in modulating insulin-stimulated mitogenic signaling.	Catechin	40-51	insulin	Homo sapiens	109-116
19777801-8	2009	Cooking-oil-fumes-induced oxidative stress decreased lung Bcl-2/Bax ratio and HSP70 expression, but catechins treatment preserved the downregulation of Bcl-2/Bax ratio and HSP70 expression.	Catechin	100-109	BCL2, apoptosis regulator	Rattus norvegicus	152-157
19777801-8	2009	Cooking-oil-fumes-induced oxidative stress decreased lung Bcl-2/Bax ratio and HSP70 expression, but catechins treatment preserved the downregulation of Bcl-2/Bax ratio and HSP70 expression.	Catechin	100-109	BCL2 associated X, apoptosis regulator	Rattus norvegicus	158-161
19777801-8	2009	Cooking-oil-fumes-induced oxidative stress decreased lung Bcl-2/Bax ratio and HSP70 expression, but catechins treatment preserved the downregulation of Bcl-2/Bax ratio and HSP70 expression.	Catechin	100-109	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	172-177
19152914-2	2009	The aim of the present study was to investigate the anti-atherosclerotic effects of catechin supplemented in the diet of apoE deficient mice at a low nutritional level and to explore the mechanisms of action by a transcriptomic approach.	Catechin	84-92	apolipoprotein E	Mus musculus	121-125
19152914-9	2009	Other genes involved in energy metabolism, lipid metabolism and lipids trafficking such as FABP4, LPL and SCARA5 were down-regulated and may contribute to the atheroprotective effect of catechin.	Catechin	186-194	fatty acid binding protein 4, adipocyte	Mus musculus	91-96
19152914-9	2009	Other genes involved in energy metabolism, lipid metabolism and lipids trafficking such as FABP4, LPL and SCARA5 were down-regulated and may contribute to the atheroprotective effect of catechin.	Catechin	186-194	lipoprotein lipase	Mus musculus	98-101
19447226-0	2009	Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway.	Catechin	0-8	serine/threonine kinase 11	Mus musculus	35-39
19447226-5	2009	In addition, phosphorylation of LKB1, which is a tumor-suppressor protein and a major AMPK-kinase, was increased by catechin treatment.	Catechin	116-124	serine/threonine kinase 11	Mus musculus	32-36
19447226-9	2009	These findings suggest that multiple effects of catechins, including anti-obesity and anti-cancer effects, are mediated, at least in part, by the activation of LKB1/AMPK in various tissues, and that these effects vary according to the catechin structure.	Catechin	48-57	serine/threonine kinase 11	Mus musculus	160-164
19447226-9	2009	These findings suggest that multiple effects of catechins, including anti-obesity and anti-cancer effects, are mediated, at least in part, by the activation of LKB1/AMPK in various tissues, and that these effects vary according to the catechin structure.	Catechin	48-56	serine/threonine kinase 11	Mus musculus	160-164
19383571-4	2009	There were three peaks of catechin at SWNTs-CTAB/GCE in the potential range of -0.4-1.0 V in PBS (pH 7.0): a reversible pair of peaks and an irreversible peak of the anodic peak.	Catechin	26-34	aminomethyltransferase	Homo sapiens	38-52
19152914-9	2009	Other genes involved in energy metabolism, lipid metabolism and lipids trafficking such as FABP4, LPL and SCARA5 were down-regulated and may contribute to the atheroprotective effect of catechin.	Catechin	186-194	scavenger receptor class A, member 5	Mus musculus	106-112
19383571-5	2009	The reductive peak current increased linearly with the concentration of catechin in the range from 3.72 x 10(-10) to 2.38 x 10(-9) M. The detection limit was 1.12 x 10(-10) M. The SWNTs-CTAB/GCE showed good stability and low detection limit, and could be applied to detect trace catechin.	Catechin	72-80	aminomethyltransferase	Homo sapiens	180-194
19383571-5	2009	The reductive peak current increased linearly with the concentration of catechin in the range from 3.72 x 10(-10) to 2.38 x 10(-9) M. The detection limit was 1.12 x 10(-10) M. The SWNTs-CTAB/GCE showed good stability and low detection limit, and could be applied to detect trace catechin.	Catechin	279-287	aminomethyltransferase	Homo sapiens	180-194
19558814-12	2009	The Ang II+catechin treatment group showed increased eNOS protein expression compared with the Ang II group (P&lt;0.05).	Catechin	11-19	nitric oxide synthase 3	Rattus norvegicus	53-57
18671164-0	2009	Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells.	Catechin	64-73	fatty acid synthase	Homo sapiens	31-50
18671164-2	2009	In this study, we found that activities of catechins on inhibiting FAS increased greatly by heating them in acid.	Catechin	43-52	fatty acid synthase	Homo sapiens	67-70
19558814-0	2009	[Effects of clearance of superoxide anion by catechin on the expression of NO and eNOS and apoptosis in endothelial progenitor cells induced by angiotensin II].	Catechin	45-53	nitric oxide synthase 3	Rattus norvegicus	82-86
19558814-12	2009	The Ang II+catechin treatment group showed increased eNOS protein expression compared with the Ang II group (P&lt;0.05).	Catechin	11-19	angiotensinogen	Rattus norvegicus	4-10
19558814-12	2009	The Ang II+catechin treatment group showed increased eNOS protein expression compared with the Ang II group (P&lt;0.05).	Catechin	11-19	angiotensinogen	Rattus norvegicus	95-101
19558814-0	2009	[Effects of clearance of superoxide anion by catechin on the expression of NO and eNOS and apoptosis in endothelial progenitor cells induced by angiotensin II].	Catechin	45-53	angiotensinogen	Rattus norvegicus	144-158
19558814-1	2009	OBJECTIVE: To evaluate the effect of clearance of superoxide anion by catechin on the expression of nitrogen monoxidum (NO) and endothelial nitricoxide synthase (eNOS) and apoptosis in endothelial progenitor cells (EPCs) induced by angiotensin II (Ang II).	Catechin	70-78	nitric oxide synthase 3	Rattus norvegicus	128-160
19558814-1	2009	OBJECTIVE: To evaluate the effect of clearance of superoxide anion by catechin on the expression of nitrogen monoxidum (NO) and endothelial nitricoxide synthase (eNOS) and apoptosis in endothelial progenitor cells (EPCs) induced by angiotensin II (Ang II).	Catechin	70-78	nitric oxide synthase 3	Rattus norvegicus	162-166
19558814-7	2009	The O2*- concentration in the Ang II and the Ang II+catechin treatment groups (81.7+/- 3.6 and 62.3+/- 2.2 U/L respectively) was significantly higher than that in the control group (33.7+/- 2.8 U/L) (P&lt;0.01).	Catechin	52-60	angiotensinogen	Rattus norvegicus	45-51
19558814-11	2009	The mRNA (P&lt;0.05) and protein expression (P&lt;0.01) of eNOS in the Ang II and the Ang II+catechin treatment groups increased significantly compared with those in the control group.	Catechin	93-101	nitric oxide synthase 3	Rattus norvegicus	59-63
19558814-11	2009	The mRNA (P&lt;0.05) and protein expression (P&lt;0.01) of eNOS in the Ang II and the Ang II+catechin treatment groups increased significantly compared with those in the control group.	Catechin	93-101	angiotensinogen	Rattus norvegicus	86-92
19558814-14	2009	Catechin might decrease the apoptosis of EPCs through the effective clearance of O2*-and the reduction of NO inactivation and of eNOS protein uncoupling.	Catechin	0-8	nitric oxide synthase 3	Rattus norvegicus	129-133
19583939-10	2009	The ACE activities and Ang II contents in plasma and renal cortices in the catechin group were much less than those in the untreated group (P &lt; 0.01).	Catechin	75-83	angiotensin I converting enzyme	Rattus norvegicus	4-7
19583939-10	2009	The ACE activities and Ang II contents in plasma and renal cortices in the catechin group were much less than those in the untreated group (P &lt; 0.01).	Catechin	75-83	angiogenin	Rattus norvegicus	23-26
19583939-12	2009	CONCLUSION: Catechin can prevent the 5/6 nephrectomized rats from decreasing of MVD and inhibit the progress of glomerular sclerosis and interstitial fibrosis by inhibiting the activity of ACE and reducing the production of Ang II.	Catechin	12-20	angiotensin I converting enzyme	Rattus norvegicus	189-192
19583939-12	2009	CONCLUSION: Catechin can prevent the 5/6 nephrectomized rats from decreasing of MVD and inhibit the progress of glomerular sclerosis and interstitial fibrosis by inhibiting the activity of ACE and reducing the production of Ang II.	Catechin	12-20	angiotensinogen	Rattus norvegicus	224-230
19420696-4	2009	It is concluded that catechins can possibly modulate CYP1A1 expression.	Catechin	21-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	53-59
18825537-0	2009	Green tea catechins in chemoprevention of cancer: a molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1).	Catechin	10-19	glutathione S-transferase kappa 1	Homo sapiens	112-137
19409206-7	2009	These results demonstrated that long-term 0.05% or 0.1% green tea catechin administration may prevent age-related spatial learning and memory decline of female C57BL/6 J mice by regulating hippocampal CREB signaling cascade.	Catechin	66-74	cAMP responsive element binding protein 1	Mus musculus	201-205
19467635-3	2009	We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells.	Catechin	73-85	interferon regulatory factor 6	Homo sapiens	172-175
19467635-3	2009	We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells.	Catechin	90-105	interferon regulatory factor 6	Homo sapiens	172-175
19467635-3	2009	We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells.	Catechin	90-105	interferon gamma	Homo sapiens	176-185
19467635-3	2009	We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells.	Catechin	90-105	tumor necrosis factor	Homo sapiens	194-203
18835362-6	2009	The presence of desferrioxamine and/or catechin inhibit tyrosine nitration both in hemin-H(2)O(2)-NO(2)(-) and in SIN-1, but they promoted protein oxidation and reduced the enzyme activity in hemin-H(2)O(2)-NO(2)(-) system, while inhibited protein oxidation and recover the enzyme activity in SIN-1 system.	Catechin	39-47	MAPK associated protein 1	Homo sapiens	114-119
19265260-3	2009	One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression.	Catechin	41-49	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	111-117
19673394-0	2009	[Epicatechin abolished TDCA-induced apoptosis in Huh7 cell by inhibiting Bax, p38 MAPK and ROS production].	Catechin	1-12	MIR7-3 host gene	Homo sapiens	49-53
19673394-0	2009	[Epicatechin abolished TDCA-induced apoptosis in Huh7 cell by inhibiting Bax, p38 MAPK and ROS production].	Catechin	1-12	BCL2 associated X, apoptosis regulator	Homo sapiens	73-76
19673394-0	2009	[Epicatechin abolished TDCA-induced apoptosis in Huh7 cell by inhibiting Bax, p38 MAPK and ROS production].	Catechin	1-12	mitogen-activated protein kinase 14	Homo sapiens	78-81
19673394-9	2009	In addition epicatechin reduced Bax expression with consequential inhibition of cytochrome C release from mitochondria, inhibition of caspase 3/7 activation and p38 MAPK phosphorylation.	Catechin	12-23	BCL2 associated X, apoptosis regulator	Homo sapiens	32-35
19673394-9	2009	In addition epicatechin reduced Bax expression with consequential inhibition of cytochrome C release from mitochondria, inhibition of caspase 3/7 activation and p38 MAPK phosphorylation.	Catechin	12-23	cytochrome c, somatic	Homo sapiens	80-92
19673394-9	2009	In addition epicatechin reduced Bax expression with consequential inhibition of cytochrome C release from mitochondria, inhibition of caspase 3/7 activation and p38 MAPK phosphorylation.	Catechin	12-23	caspase 3	Homo sapiens	134-143
19673394-9	2009	In addition epicatechin reduced Bax expression with consequential inhibition of cytochrome C release from mitochondria, inhibition of caspase 3/7 activation and p38 MAPK phosphorylation.	Catechin	12-23	mitogen-activated protein kinase 14	Homo sapiens	161-164
19673394-10	2009	CONCLUSION: Epicatechin protects Huh7 cells from oxidative stress and mitochondria-induced apoptosis.	Catechin	12-23	MIR7-3 host gene	Homo sapiens	33-37
19673394-11	2009	The molecular mechanisms of anti-apoptotic effects of epicatechin were associated with inhibition of p38 MAPK phosphorylation and Bax expression, and reduction of ROS production.	Catechin	54-65	mitogen-activated protein kinase 14	Homo sapiens	101-104
19673394-11	2009	The molecular mechanisms of anti-apoptotic effects of epicatechin were associated with inhibition of p38 MAPK phosphorylation and Bax expression, and reduction of ROS production.	Catechin	54-65	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
19136268-3	2009	Recently, significant advances were achieved in understanding the biosynthesis of their main subunits: (+)-catechin and (-)-epicatechin, produced by catalysis of leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), respectively.	Catechin	103-115	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	167-190
19136268-3	2009	Recently, significant advances were achieved in understanding the biosynthesis of their main subunits: (+)-catechin and (-)-epicatechin, produced by catalysis of leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), respectively.	Catechin	103-115	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	226-229
19136268-3	2009	Recently, significant advances were achieved in understanding the biosynthesis of their main subunits: (+)-catechin and (-)-epicatechin, produced by catalysis of leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), respectively.	Catechin	120-135	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	167-190
19136268-3	2009	Recently, significant advances were achieved in understanding the biosynthesis of their main subunits: (+)-catechin and (-)-epicatechin, produced by catalysis of leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), respectively.	Catechin	120-135	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	226-229
19350454-6	2009	Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1.	Catechin	0-8	sulfotransferase family 1A member 1	Homo sapiens	35-43
19350454-6	2009	Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1.	Catechin	0-8	sulfotransferase family 1A member 3	Homo sapiens	48-56
19350454-6	2009	Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1.	Catechin	13-24	sulfotransferase family 1A member 1	Homo sapiens	35-43
19350454-6	2009	Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1.	Catechin	13-24	sulfotransferase family 1A member 3	Homo sapiens	48-56
18983988-11	2009	Our results suggest (a) that bioactive nut constituents in the non-lipophilic extracts were more effective than lipophilic extracts for cytoprotection against hydroperoxide induced oxidative stress, (b) catechin compounds under physiological conditions were likely effective at preventing glyoxal cytotoxicity by trapping glyoxal or reversing early stage carbonylation (Schiff base formation).	Catechin	203-211	NUT midline carcinoma, family member 1	Rattus norvegicus	39-42
19074160-8	2009	Quantitative analyses of all tested wines and of samples collected at various time points (Days 0-16) of the "mash fermentation", which is only performed for red wine, revealed that flavonoids of the catechin family, which potently inhibit PDGFR signalling, are extracted from grape seeds and skins during this process and therefore accumulate specifically in red wine.	Catechin	200-208	platelet derived growth factor receptor beta	Homo sapiens	240-245
19271168-13	2009	In vitro assays for the inhibition of pancreatic lipase by oolong tea extract and catechins suggest that the mechanism for oolong tea to prevent hyperlipidemia may be related to the regulative action of oolong tea catechins in lipoprotein activity.	Catechin	82-91	pancreatic lipase	Homo sapiens	38-55
19271168-13	2009	In vitro assays for the inhibition of pancreatic lipase by oolong tea extract and catechins suggest that the mechanism for oolong tea to prevent hyperlipidemia may be related to the regulative action of oolong tea catechins in lipoprotein activity.	Catechin	214-223	pancreatic lipase	Homo sapiens	38-55
18679731-3	2009	As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes.	Catechin	120-129	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	101-104
19203663-1	2009	BACKGROUND: Previously, we presented evidence that at physiologic concentrations the green tea catechin, epigallocatechin gallate (EGCG), inhibited attachment of HIV-1 glycoprotein 120 to the CD4 molecule on T cells, but the downstream effects of EGCG on HIV-1 infectivity were not determined.	Catechin	95-103	CD4 molecule	Homo sapiens	192-195
18825537-0	2009	Green tea catechins in chemoprevention of cancer: a molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1).	Catechin	10-19	glutathione S-transferase pi 1	Homo sapiens	139-147
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	51-60	glutathione S-transferase pi 1	Homo sapiens	107-115
18495458-5	2009	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Catechin	0-11	protein kinase C alpha	Homo sapiens	278-288
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	51-60	glutathione S-transferase kappa 1	Homo sapiens	126-130
18495458-5	2009	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Catechin	0-11	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	333-338
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	Catechin	15-17	F-box protein 32	Mus musculus	85-94
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	164-173	glutathione S-transferase pi 1	Homo sapiens	107-115
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	Catechin	15-17	tripartite motif-containing 63	Mus musculus	99-105
18495458-5	2009	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Catechin	0-11	protein kinase C delta	Homo sapiens	427-436
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	164-173	glutathione S-transferase kappa 1	Homo sapiens	126-130
19070648-5	2009	(+/-)-Catechin attenuated the phosphorylation of c-Jun and recovered the phosphorylation of GSK-3beta (Ser9).	Catechin	0-14	jun proto-oncogene	Mus musculus	49-54
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	190-201	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	79-102
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	190-201	leucoanthocyanidin reductase 1	Vitis vinifera	107-137
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	190-201	leucoanthocyanidin reductase 2	Vitis vinifera	238-268
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	193-201	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	79-102
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	193-201	leucoanthocyanidin reductase 1	Vitis vinifera	107-137
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Catechin	193-201	leucoanthocyanidin reductase 2	Vitis vinifera	238-268
19262011-8	2009	As expected, EC, ECg, EGCg, and quercetin significantly suppressed phosphorylation of ERK, corresponding to the up-regulation of atrogenes induced by 3D-clinorotation.	Catechin	13-15	mitogen-activated protein kinase 1	Mus musculus	86-89
19262011-9	2009	These results suggest that antioxidative nutrients, such as catechins and quercetin, suppress atrogene expression in skeletal muscle cells, possibly through the inhibition of ERK signaling.	Catechin	60-69	mitogen-activated protein kinase 1	Mus musculus	175-178
19074207-1	2009	This study evaluated the influence of a green tea catechin beverage on body composition and fat distribution in overweight and obese adults during exercise-induced weight loss.	Catechin	50-58	FAT atypical cadherin 1	Homo sapiens	92-95
19074207-8	2009	These findings suggest that green tea catechin consumption enhances exercise-induced changes in abdominal fat and serum TG.	Catechin	38-46	FAT atypical cadherin 1	Homo sapiens	106-109
19008868-4	2009	Adiponectin, which is negatively correlated with visceral adiposity, increased significantly only in the catechin group.	Catechin	105-113	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
19070648-5	2009	(+/-)-Catechin attenuated the phosphorylation of c-Jun and recovered the phosphorylation of GSK-3beta (Ser9).	Catechin	0-14	glycogen synthase kinase 3 beta	Mus musculus	92-101
19070648-6	2009	These results suggested that the suppression of JNK and GSK-3beta signaling cascades might contribute to the neuroprotective effect of (+/-)-catechin against toxicity of MPTP.	Catechin	135-149	mitogen-activated protein kinase 8	Mus musculus	48-51
19070648-6	2009	These results suggested that the suppression of JNK and GSK-3beta signaling cascades might contribute to the neuroprotective effect of (+/-)-catechin against toxicity of MPTP.	Catechin	135-149	glycogen synthase kinase 3 beta	Mus musculus	56-65
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Catechin	102-110	hematopoietic prostaglandin D synthase	Rattus norvegicus	159-184
18951882-0	2009	(-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation.	Catechin	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	100-110
18951882-4	2009	(-)-Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs.	Catechin	0-12	adiponectin, C1Q and collagen domain containing	Homo sapiens	78-89
18951882-4	2009	(-)-Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs.	Catechin	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	91-139
18951882-4	2009	(-)-Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs.	Catechin	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	141-150
18951882-4	2009	(-)-Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs.	Catechin	0-12	fatty acid binding protein 4	Homo sapiens	153-158
18951882-4	2009	(-)-Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs.	Catechin	0-12	lipoprotein lipase	Homo sapiens	164-167
18951882-5	2009	In addition, (-)-catechin upregulated the secretion of adiponectin in hBM-MSC culture.	Catechin	13-25	adiponectin, C1Q and collagen domain containing	Homo sapiens	55-66
18951882-6	2009	Using a reporter gene assay and a competitive ligand binding study, (-)-catechin also significantly activated PPARgamma in a dose-dependent fashion; however, (+)-catechin, the enantiomer of (-)-catechin, was not effective as a PPARgamma agonist, which seems to imply that the effect of (-)-catechin on PPARgamma is stereospecific.	Catechin	68-80	peroxisome proliferator activated receptor gamma	Homo sapiens	110-119
18951882-6	2009	Using a reporter gene assay and a competitive ligand binding study, (-)-catechin also significantly activated PPARgamma in a dose-dependent fashion; however, (+)-catechin, the enantiomer of (-)-catechin, was not effective as a PPARgamma agonist, which seems to imply that the effect of (-)-catechin on PPARgamma is stereospecific.	Catechin	68-80	peroxisome proliferator activated receptor gamma	Homo sapiens	227-236
18951882-6	2009	Using a reporter gene assay and a competitive ligand binding study, (-)-catechin also significantly activated PPARgamma in a dose-dependent fashion; however, (+)-catechin, the enantiomer of (-)-catechin, was not effective as a PPARgamma agonist, which seems to imply that the effect of (-)-catechin on PPARgamma is stereospecific.	Catechin	68-80	peroxisome proliferator activated receptor gamma	Homo sapiens	227-236
18951882-7	2009	In conclusion, our data suggest that (-)-catechin promotes adipocyte differentiation and increased sensitivity to insulin in part by direct activation of PPARgamma, which could be at the basis of the observed pharmacological benefits of green tea intake in reducing the risk of type 2 diabetes.	Catechin	37-49	peroxisome proliferator activated receptor gamma	Homo sapiens	154-163
19910679-0	2009	Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts.	Catechin	0-9	C-C motif chemokine ligand 20	Homo sapiens	18-23
19910679-0	2009	Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts.	Catechin	0-9	interleukin 17A	Homo sapiens	38-44
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Catechin	58-66	cystathionine beta-synthase	Mus musculus	155-182
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Catechin	58-66	cystathionine beta-synthase	Mus musculus	184-187
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Catechin	102-110	hematopoietic prostaglandin D synthase	Rattus norvegicus	186-189
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Catechin	102-110	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	195-227
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Catechin	102-110	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	229-233
19838946-6	2009	Dietary quercetin significantly decreased activity of hepatic GST (24%), whereas dietary catechin significantly decreased NQO1 activity (26%) compared to controls.	Catechin	89-97	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	122-126
19548356-5	2008	The intrinsic capacity of catechins to form quinone type metabolites upon their oxidation was demonstrated using incubations of epigallocatechin (EGC) and EGCG with tyrosinase and the GSH-trapping method.	Catechin	26-35	tyrosinase	Mus musculus	165-175
19035783-2	2008	Using original anti-mucin monoclonal antibodies, we studied the influences of long-term administration of catechins on the quantity and quality of mucin in rat gastrointestinal mucosa.	Catechin	106-115	solute carrier family 13 member 2	Rattus norvegicus	147-152
19035783-3	2008	Administration of 0.5% tea catechins significantly increased the mucin content of the ileum, but not the stomach.	Catechin	27-36	solute carrier family 13 member 2	Rattus norvegicus	65-70
19035783-6	2008	These findings indicate that tea catechins modulate ileal mucin metabolism in the ileal mucosa, suggesting that further studies focusing on the ileal epithelium will assist in further elucidation of the mechanism of catechin effects.	Catechin	33-42	solute carrier family 13 member 2	Rattus norvegicus	58-63
19035783-6	2008	These findings indicate that tea catechins modulate ileal mucin metabolism in the ileal mucosa, suggesting that further studies focusing on the ileal epithelium will assist in further elucidation of the mechanism of catechin effects.	Catechin	33-41	solute carrier family 13 member 2	Rattus norvegicus	58-63
18479902-0	2008	Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue.	Catechin	4-13	uncoupling protein 1	Rattus norvegicus	45-65
18479902-1	2008	The aim of the present study was to determine whether the antiobesity effects of tea catechins (TCs) are associated with the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT).	Catechin	85-94	uncoupling protein 1	Rattus norvegicus	139-159
18479902-1	2008	The aim of the present study was to determine whether the antiobesity effects of tea catechins (TCs) are associated with the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT).	Catechin	85-94	uncoupling protein 1	Rattus norvegicus	161-165
18480242-0	2008	Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice.	Catechin	4-12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
19189648-0	2008	Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.	Catechin	10-18	fatty acid synthase	Homo sapiens	28-47
18358230-0	2008	The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins.	Catechin	102-111	ribosomal protein SA	Homo sapiens	18-40
18358230-6	2008	Downregulation of 67LR expression caused a reduction of both activities of galloylated catechins.	Catechin	87-96	ribosomal protein SA	Homo sapiens	18-22
18358230-7	2008	These results suggest that both the galloyl moiety and the B-ring hydroxylation pattern contribute to the exertion of biological activities of tea catechins and their 67LR-dependencies.	Catechin	147-156	ribosomal protein SA	Homo sapiens	167-171
18358827-3	2008	We have demonstrated that exposure of human endothelial cells to (-)-epicatechin elevates the cellular levels of NO* and cyclic GMP and protects against oxidative stress elicited by proinflammatory agonists.	Catechin	65-80	5'-nucleotidase, cytosolic II	Homo sapiens	128-131
18829315-0	2008	Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules.	Catechin	53-61	ribonuclease A family member 1, pancreatic	Homo sapiens	22-29
18829315-0	2008	Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules.	Catechin	66-77	ribonuclease A family member 1, pancreatic	Homo sapiens	22-29
18842789-0	2008	Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men.	Catechin	38-53	endothelin 1	Homo sapiens	95-107
18842789-8	2008	Quercetin and (-)-epicatechin resulted in a significant reduction in plasma endothelin-1 concentration (P &lt; 0.05), but only quercetin significantly decreased the urinary endothelin-1 concentration.	Catechin	14-29	endothelin 1	Homo sapiens	76-88
18842789-11	2008	CONCLUSIONS: Dietary flavonoids, such as quercetin and (-)-epicatechin, can augment nitric oxide status and reduce endothelin-1 concentrations and may thereby improve endothelial function.	Catechin	55-70	endothelin 1	Homo sapiens	115-127
18611398-6	2008	The results showed that grape seed polyphenols catechin and Pc B(4) pretreatment would protect cardiomyocytes against doxorubicin-induced toxicity by decreasing reactive oxygen species generation as well as the number of apoptotic cells, preventing DNA fragmentation, regulating the expression levels of the pro-apoptotic protein Bax-alpha and the anti-apoptotic protein Bcl-2, and inhibiting apoptotic signaling pathways.	Catechin	47-55	BCL2 apoptosis regulator	Homo sapiens	371-376
18624917-6	2008	We found, using immunocytochemistry, that Nrf2 accumulated in the nuclei of astrocytes following exposure to tert-butylhydroquinone (100 microM) and (-)epicatechin (100 nM).	Catechin	152-163	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
18624917-7	2008	(-)Epicatechin signalling via Nrf2 was inhibited by wortmannin implicating a phosphatidylinositol 3-kinase-dependent pathway.	Catechin	3-14	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
18567705-15	2008	MMP-9 activity demonstrated limited increases in the infarct region with epicatechin.	Catechin	73-84	matrix metallopeptidase 9	Rattus norvegicus	0-5
18466756-0	2008	Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase.	Catechin	40-55	myeloperoxidase	Homo sapiens	65-80
18466756-3	2008	Since (-)-epicatechin has tentatively been identified as substrate of MPO, we studied the one-electron oxidation of (-)-epicatechin by MPO.	Catechin	6-21	myeloperoxidase	Homo sapiens	70-73
18466756-3	2008	Since (-)-epicatechin has tentatively been identified as substrate of MPO, we studied the one-electron oxidation of (-)-epicatechin by MPO.	Catechin	6-21	myeloperoxidase	Homo sapiens	135-138
18466756-3	2008	Since (-)-epicatechin has tentatively been identified as substrate of MPO, we studied the one-electron oxidation of (-)-epicatechin by MPO.	Catechin	116-131	myeloperoxidase	Homo sapiens	70-73
18466756-3	2008	Since (-)-epicatechin has tentatively been identified as substrate of MPO, we studied the one-electron oxidation of (-)-epicatechin by MPO.	Catechin	116-131	myeloperoxidase	Homo sapiens	135-138
18466756-5	2008	Second order rate constants for the (-)-epicatechin-mediated conversion of MPO-compound I to compound II and compound II to resting enzyme were estimated to be 1.9 x 10(7) and 4.5 x 10(6) M(-1)s(-1), respectively (pH 7, 25 degrees C).	Catechin	36-51	myeloperoxidase	Homo sapiens	75-78
18466756-6	2008	The data indicate that (-)-epicatechin is capable of undergoing fast MPO-mediated one-electron oxidation.	Catechin	23-38	myeloperoxidase	Homo sapiens	69-72
18480242-6	2008	The mRNA levels of mitochondria-related molecules, such as peroxisome proliferator-activated receptor-gamma coactivator-1, cytochrome c oxidase-II, III, and IV in skeletal muscle were also higher in SAMP1 mice given both catechins and exercise.	Catechin	221-230	transmembrane protein 201	Mus musculus	199-204
18480242-7	2008	Moreover, oxidative stress measured as thiobarbituric reactive substances was lower in SAMP1 groups fed catechins than in the SAMP1 control group.	Catechin	104-113	transmembrane protein 201	Mus musculus	87-92
18480242-1	2008	Catechins, which are abundant in green tea, possess a variety of biologic actions, and their clinical application has been extensively investigated.	Catechin	0-9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	39-42
18480242-4	2008	On the other hand, the endurance capacity of SAMP1 mice fed 0.35% (wt/wt) catechins remained at the initial level and was significantly higher than that of SAMP1 mice not fed catechins.	Catechin	74-83	transmembrane protein 201	Mus musculus	45-50
18480242-5	2008	In SAMP1 mice fed catechins and given exercise, oxygen consumption was significantly increased, and there was an increase in skeletal muscle fatty acid beta-oxidation.	Catechin	18-27	transmembrane protein 201	Mus musculus	3-8
18562575-0	2008	(+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.	Catechin	0-12	tumor necrosis factor	Mus musculus	91-100
18214969-2	2008	In particular, earlier studies showed that green tea catechins are powerful inhibitors of bovine liver and chicken liver DHFR.	Catechin	53-62	dihydrofolate reductase	Gallus gallus	121-125
18537694-0	2008	Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial dysfunction.	Catechin	55-64	insulin	Homo sapiens	76-83
18533286-0	2008	Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells.	Catechin	10-18	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	28-58
18533286-2	2008	In the present study, we investigated the effects of green tea catechins on the mRNA level and promoter activity of hepatic cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, in human hepatoma cells.	Catechin	63-72	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	124-154
18533286-2	2008	In the present study, we investigated the effects of green tea catechins on the mRNA level and promoter activity of hepatic cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, in human hepatoma cells.	Catechin	63-72	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	156-162
18533286-7	2008	These results suggest that the expression of the CYP7A1 gene may be directly regulated by green tea catechins at the transcriptional level.	Catechin	100-109	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	49-55
18549879-12	2008	Catechin compounds have fewer adverse effects than chemotherapeutic agents and hence can be used as proof-of-concept in cancer therapeutics to suppress growth and metastasis by targeting proteins such as bFGF.	Catechin	0-8	fibroblast growth factor 2	Mus musculus	204-208
18562575-6	2008	The differential elevation is further evidenced by the increased production of IL-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the B16F-10 injected, (+)-catechin-treated animals.	Catechin	166-174	interleukin 2	Mus musculus	79-83
18562575-6	2008	The differential elevation is further evidenced by the increased production of IL-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the B16F-10 injected, (+)-catechin-treated animals.	Catechin	166-174	tissue inhibitor of metalloproteinase 1	Mus musculus	88-127
18562575-6	2008	The differential elevation is further evidenced by the increased production of IL-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the B16F-10 injected, (+)-catechin-treated animals.	Catechin	166-174	tissue inhibitor of metalloproteinase 1	Mus musculus	129-135
18562575-7	2008	In vitro L929 bioassay revealed the inhibition of TNF-alpha production by (+)-catechin treatment.	Catechin	74-86	tumor necrosis factor	Mus musculus	50-59
18562575-10	2008	(+)-Catechin also showed inhibitory effect on VEGF mRNA levels in B16F-10 melanoma cells.	Catechin	0-12	vascular endothelial growth factor A	Rattus norvegicus	46-50
18562575-11	2008	(+)-Catechin inhibited the production of NO and TNF-alpha in LPS-stimulated primary macrophages.	Catechin	0-12	tumor necrosis factor	Mus musculus	48-57
18562575-12	2008	Taken together, these results demonstrate that (+)-catechin inhibits tumour-specific angiogenesis by regulating the production of pro- and anti-angiogenic factors such as pro-inflammatory cytokines, nitric oxide, VEGF, IL-2 and TIMP-1.	Catechin	47-59	vascular endothelial growth factor A	Mus musculus	213-217
18562575-12	2008	Taken together, these results demonstrate that (+)-catechin inhibits tumour-specific angiogenesis by regulating the production of pro- and anti-angiogenic factors such as pro-inflammatory cytokines, nitric oxide, VEGF, IL-2 and TIMP-1.	Catechin	47-59	interleukin 2	Mus musculus	219-223
18562575-12	2008	Taken together, these results demonstrate that (+)-catechin inhibits tumour-specific angiogenesis by regulating the production of pro- and anti-angiogenic factors such as pro-inflammatory cytokines, nitric oxide, VEGF, IL-2 and TIMP-1.	Catechin	47-59	tissue inhibitor of metalloproteinase 1	Mus musculus	228-234
18562575-13	2008	These results also suggest that (+)-catechin could significantly inhibit nitrite and TNF-alpha production in LPS-stimulated macrophages.	Catechin	32-44	tumor necrosis factor	Mus musculus	85-94
18022615-1	2008	Epigallocatechin-3-gallate (EGCG), a green tea catechin, has been shown to inhibit signaling pathways involved in inflammation, including nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), which are important inducers of pro-inflammatory mediators.	Catechin	8-16	jun proto-oncogene	Mus musculus	176-195
18313308-2	2008	In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP(+)-competitive inhibitors of G6PD and other enzymes that employ NADP(+) as a coenzyme, such as IDH and 6PGD.	Catechin	135-144	glucose-6-phosphate dehydrogenase	Homo sapiens	106-110
18313308-2	2008	In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP(+)-competitive inhibitors of G6PD and other enzymes that employ NADP(+) as a coenzyme, such as IDH and 6PGD.	Catechin	135-144	glucagon	Homo sapiens	147-150
18249068-11	2008	Catechin significantly reversed the changes in thioredoxin peroxidase, 5-hydroxytryptamine receptor, peroxiredoxin 6 and pyruvate dehydrogenase (p&lt;0.05).	Catechin	0-8	peroxiredoxin 6	Homo sapiens	101-116
18197555-2	2008	EGCG has an IC(50) value of 70 nM for inhibiting human liver COMT-mediated O-methylation of 2-hydroxyestradiol, which was 210-760 times more potent than catechin, epigallocatechin and epicatechin.	Catechin	153-161	catechol-O-methyltransferase	Homo sapiens	61-65
18197555-2	2008	EGCG has an IC(50) value of 70 nM for inhibiting human liver COMT-mediated O-methylation of 2-hydroxyestradiol, which was 210-760 times more potent than catechin, epigallocatechin and epicatechin.	Catechin	184-195	catechol-O-methyltransferase	Homo sapiens	61-65
18398871-7	2008	Quercetin aglycone was identified as a potent Cyp1A inhibitor, whereas phloretin and (-)-epicatechin were the most potent cyclooxygenase 1 (Cox-1) inhibitors.	Catechin	85-100	cytochrome c oxidase subunit I	Malus domestica	122-138
18398871-7	2008	Quercetin aglycone was identified as a potent Cyp1A inhibitor, whereas phloretin and (-)-epicatechin were the most potent cyclooxygenase 1 (Cox-1) inhibitors.	Catechin	85-100	cytochrome c oxidase subunit I	Malus domestica	140-145
18022615-1	2008	Epigallocatechin-3-gallate (EGCG), a green tea catechin, has been shown to inhibit signaling pathways involved in inflammation, including nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), which are important inducers of pro-inflammatory mediators.	Catechin	8-16	jun proto-oncogene	Mus musculus	197-201
18711772-5	2008	In particular, the content of (+)-catechin was significantly higher than those of the other compounds, and the (+)-catechin structure was located in procyanidins B-1 and B-3.	Catechin	111-123	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	162-173
18850185-3	2007	Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1).	Catechin	50-59	interferon gamma	Homo sapiens	166-182
18175946-5	2008	Cell cycle analyses, DNA fragmentation assays, and TUNEL assays as well as Western blot assays suggested that these catechins inhibited cell growth through mitogen-activated protein kinase (MAPK)-mediated apoptosis rather than cell cycle regulation.	Catechin	116-125	mitogen-activated protein kinase 1	Homo sapiens	190-194
19544670-12	2008	The catechin gallates, theaflavins and ellagic acid inhibited NDPK-B completely with the rank order of potency: EA &gt; theaflavins &gt; EGCG &gt; ECG &gt; PAPS.	Catechin	4-12	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	62-68
18202537-4	2007	In catechin-fed rats, amounts of 8-OH dG and albumin excreted into the urine determined on days 71-72, and kidney ACE activity determined on day 76, were lower than those in control rats.	Catechin	3-11	angiotensin I converting enzyme	Rattus norvegicus	114-117
18071271-1	2007	This study was designed to determine whether dietary epigallocatechin-3-gallate (EGCG), the most abundant catechin polyphenol in green tea, can protect the liver from cytochrome P450 2E1 (CYP2E1)-dependent alcoholic liver damage.	Catechin	61-69	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	167-186
17944533-5	2007	Applying this screening paradigm, we determined that a bioactive green tea extract contains an assemblage of catechins that were individually characterized for their respective protective effects against huntingtin and alpha-synuclein toxicity.	Catechin	109-118	huntingtin	Homo sapiens	204-214
17944533-5	2007	Applying this screening paradigm, we determined that a bioactive green tea extract contains an assemblage of catechins that were individually characterized for their respective protective effects against huntingtin and alpha-synuclein toxicity.	Catechin	109-118	synuclein alpha	Homo sapiens	219-234
17490800-4	2007	Glutathione S-transferase and cytochrome P450 2E1 activities and lipid peroxidation were found to be markedly inhibited by tea catechins.	Catechin	127-136	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	30-49
17764926-0	2007	Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.	Catechin	10-18	activating transcription factor 3	Homo sapiens	77-81
17764926-0	2007	Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.	Catechin	10-18	early growth response 1	Homo sapiens	86-91
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	Catechin	52-64	tyrosinase	Homo sapiens	124-134
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	Catechin	52-64	tyrosinase	Homo sapiens	209-219
18007557-0	2007	New role of antinutritional factors, phytic acid and catechin in the treatment of CCl4 intoxication.	Catechin	53-61	C-C motif chemokine ligand 4	Rattus norvegicus	82-86
17991670-11	2007	In the 7-mo interventional study, the 14 patients who received daily supplementation of catechins for 3 mo had less predialysis plasma hydrogen peroxide activity, lower hypochlorous acid activity, and lower phosphatidylcholine hydroperoxide, C-reactive protein, and proinflammatory cytokine concentrations than did the 30 hemodialysis patients who received placebo.	Catechin	88-97	C-reactive protein	Homo sapiens	242-260
17885080-4	2007	Levels of transcripts encoding dihydroflavonol reductase, ANS, and anthocyanidin reductase (ANR), the enzyme responsible for conversion of anthocyanidin to (-)-epicatechin, paralleled the accumulation of PAs in developing seeds, whereas LAR transcripts appeared to be more transiently expressed.	Catechin	156-171	leucoanthocyanidin dioxygenase-like	Nicotiana tabacum	58-61
17880176-2	2007	In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins).	Catechin	386-395	catechol-O-methyltransferase	Homo sapiens	88-92
17490800-7	2007	Our results indicate that tea catechins prevent molecular degradation in oxidative stress conditions by directly altering the subcellular ROS production, glutathione metabolism and cytochrome P450 2E1 activity.	Catechin	30-39	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	181-200
17560937-6	2007	From the effect of 3,5-dinitrocatechol, an inhibitor of catechol-O-methyltransferase (COMT), on HUVEC it is concluded that (-)-epicatechin serves as "prodrug" for conversion to apocynin-like NADPH oxidase inhibitors.	Catechin	123-138	catechol-O-methyltransferase	Homo sapiens	56-84
17827674-0	2007	Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea catechins and black tea theaflavins.	Catechin	84-93	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	48-53
18521193-0	2007	Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.	Catechin	10-19	minichromosome maintenance complex component 7	Mus musculus	54-58
17560542-4	2007	Flavone, flavonol, and flavanone but not catechin inhibited the specific binding between the AhR and 3-methylcholanthrene dose-dependently, indicating that the former three subclasses possibly act as competitive antagonists of the AhR.	Catechin	41-49	aryl hydrocarbon receptor	Homo sapiens	93-96
17436062-9	2007	Taken together, the data presented here provide evidence showing that among these tea catechins, EGCG and ECG are relatively effective inhibitors on SMC-ECM interaction and their action mechanisms are through interference with SMC"s integrin beta1 receptor and binding to ECM proteins.	Catechin	86-95	integrin subunit beta 1	Rattus norvegicus	233-247
17560937-6	2007	From the effect of 3,5-dinitrocatechol, an inhibitor of catechol-O-methyltransferase (COMT), on HUVEC it is concluded that (-)-epicatechin serves as "prodrug" for conversion to apocynin-like NADPH oxidase inhibitors.	Catechin	123-138	catechol-O-methyltransferase	Homo sapiens	86-90
16970948-6	2007	These results suggest that green tea catechins lowered plasma, liver and aortic cholesterol in the cholesterol-fed rabbit by lowering cholesterol synthesis and upregulating the hepatic LDL receptor.	Catechin	37-46	low-density lipoprotein receptor	Oryctolagus cuniculus	185-197
17666787-7	2007	The results demonstrated that EGCG may exhibit protective effects against AGEs-induced injury in neuronal cells through its antioxidative properties, as well as by interfering with AGEs-RAGE interaction mediated pathways, suggesting a beneficial role for this tea catechin against neurodegenerative diseases.	Catechin	264-272	long intergenic non-protein coding RNA 914	Homo sapiens	186-190
17384142-6	2007	The selective nitration inhibitor epicatechin enhanced VEGF"s angiogenic function in activating VEGFR2, c-Src, and promoting endothelial cell growth, migration, and tube formation in vitro and retinal neovascularization in vivo.	Catechin	34-45	vascular endothelial growth factor A	Homo sapiens	55-59
17384142-6	2007	The selective nitration inhibitor epicatechin enhanced VEGF"s angiogenic function in activating VEGFR2, c-Src, and promoting endothelial cell growth, migration, and tube formation in vitro and retinal neovascularization in vivo.	Catechin	34-45	kinase insert domain receptor	Homo sapiens	96-102
17384142-6	2007	The selective nitration inhibitor epicatechin enhanced VEGF"s angiogenic function in activating VEGFR2, c-Src, and promoting endothelial cell growth, migration, and tube formation in vitro and retinal neovascularization in vivo.	Catechin	34-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-109
17582541-0	2007	A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats.	Catechin	12-20	low density lipoprotein receptor	Rattus norvegicus	53-85
17574044-12	2007	In combination, catechin and IP6 amplified VEGF reduction compared to each agent in MIAPACA and control (P &lt; 0.002).	Catechin	16-24	vascular endothelial growth factor A	Homo sapiens	43-47
17298385-7	2007	(-)Epicatechin and 3"-O-methyl-(-)epicatechin treatments (100 nmol/L) increased CRE-luciferase activity in cortical neurons in a partially ERK-dependent manner, suggesting the potential to increase CREB-mediated gene expression.	Catechin	3-14	mitogen-activated protein kinase 1	Homo sapiens	139-142
17298385-0	2007	(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.	Catechin	3-14	mitogen-activated protein kinase 1	Homo sapiens	26-29
17539658-3	2007	Our previous study demonstrated that (-)-epigallocatechin 3-gallate (EGCG), the green tea catechin, could down-regulate FAS expression by suppressing EGFR (epidermal growth factor receptor) signaling and downstream phosphatidylinositol 3-kinase (PI3K)/Akt activation in the MCF-7 breast cancer cell line.	Catechin	49-57	fatty acid synthase	Homo sapiens	120-123
17539658-3	2007	Our previous study demonstrated that (-)-epigallocatechin 3-gallate (EGCG), the green tea catechin, could down-regulate FAS expression by suppressing EGFR (epidermal growth factor receptor) signaling and downstream phosphatidylinositol 3-kinase (PI3K)/Akt activation in the MCF-7 breast cancer cell line.	Catechin	49-57	epidermal growth factor receptor	Homo sapiens	150-154
17049832-0	2007	Green tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells.	Catechin	10-18	ephrin A1	Homo sapiens	28-37
17298385-7	2007	(-)Epicatechin and 3"-O-methyl-(-)epicatechin treatments (100 nmol/L) increased CRE-luciferase activity in cortical neurons in a partially ERK-dependent manner, suggesting the potential to increase CREB-mediated gene expression.	Catechin	3-14	cAMP responsive element binding protein 1	Homo sapiens	198-202
17049832-4	2007	However, the inhibitory effect of green tea catechins on ephrin-A1-mediated tumor angiogenesis has not been demonstrated yet.	Catechin	44-53	ephrin A1	Homo sapiens	57-66
17049832-8	2007	The green tea catechin EGCG inhibited ephrin-A1-mediated endothelial cell migration, as well as tumor angiogenesis, in a dose-dependent manner.	Catechin	14-22	ephrin A1	Homo sapiens	38-47
17298385-0	2007	(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.	Catechin	3-14	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	94-99
17298385-2	2007	We investigated in primary cortical neurons, the ability of the flavan-3-ol, (-)epicatechin, and its human metabolites at physiologically relevant concentrations, to stimulate phosphorylation of the transcription factor cAMP-response element binding protein (CREB), a regulator of neuronal viability and synaptic plasticity.	Catechin	77-91	cAMP responsive element binding protein 1	Homo sapiens	220-257
17298385-2	2007	We investigated in primary cortical neurons, the ability of the flavan-3-ol, (-)epicatechin, and its human metabolites at physiologically relevant concentrations, to stimulate phosphorylation of the transcription factor cAMP-response element binding protein (CREB), a regulator of neuronal viability and synaptic plasticity.	Catechin	77-91	cAMP responsive element binding protein 1	Homo sapiens	259-263
17298385-8	2007	mRNA levels of the glutamate receptor subunit GluR2 increased by 60%, measured 18 h after a 15 min exposure to (-)epicatechin and this translated into an increase in GluR2 protein.	Catechin	111-125	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	46-51
17298385-3	2007	(-)Epicatechin at 100-300 nmol/L stimulated a rapid, extracellular signal-regulated kinase (ERK)- and PI3K-dependent, increase in CREB phosphorylation.	Catechin	3-14	mitogen-activated protein kinase 1	Homo sapiens	53-90
17298385-3	2007	(-)Epicatechin at 100-300 nmol/L stimulated a rapid, extracellular signal-regulated kinase (ERK)- and PI3K-dependent, increase in CREB phosphorylation.	Catechin	3-14	mitogen-activated protein kinase 1	Homo sapiens	92-95
17298385-8	2007	mRNA levels of the glutamate receptor subunit GluR2 increased by 60%, measured 18 h after a 15 min exposure to (-)epicatechin and this translated into an increase in GluR2 protein.	Catechin	111-125	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	166-171
17298385-3	2007	(-)Epicatechin at 100-300 nmol/L stimulated a rapid, extracellular signal-regulated kinase (ERK)- and PI3K-dependent, increase in CREB phosphorylation.	Catechin	3-14	cAMP responsive element binding protein 1	Homo sapiens	130-134
17298385-5	2007	(-)Epicatechin also stimulated ERK and Akt phosphorylation with similar bell-shaped concentration-response characteristics.	Catechin	3-14	mitogen-activated protein kinase 1	Homo sapiens	31-34
17298385-9	2007	Thus, (-)epicatechin has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis.	Catechin	9-20	cAMP responsive element binding protein 1	Homo sapiens	51-55
17298385-5	2007	(-)Epicatechin also stimulated ERK and Akt phosphorylation with similar bell-shaped concentration-response characteristics.	Catechin	3-14	AKT serine/threonine kinase 1	Homo sapiens	39-42
17298385-6	2007	The human metabolite 3"-O-methyl-(-)epicatechin was as effective as (-)epicatechin at stimulating ERK phosphorylation, but (-)epicatechin glucuronide was inactive.	Catechin	33-47	mitogen-activated protein kinase 1	Homo sapiens	98-101
17298385-9	2007	Thus, (-)epicatechin has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis.	Catechin	9-20	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	95-100
17293380-4	2007	The enzyme kinetics of SULT1A1 allozymes and SULT1E1 were characterized for the polyphenolic substrates apigenin, chrysin, epicatechin, quercetin, and resveratrol.	Catechin	123-134	sulfotransferase family 1A member 1	Homo sapiens	23-30
17115410-2	2007	Growth of transgenic MEF cells overexpressing tNOX was inhibited by low concentrations of the green tea catechin (-)-epigallocatechin-3-gallate (EGCg) or the synthetic isoflavene phenoxodiol.	Catechin	104-112	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	46-50
17458979-3	2007	However, polyphenols, except for procyanidin, in AP (i.e., catechins, chalcones, and phenol carboxylic acids) showed weak inhibitory activities on pancreatic lipase.	Catechin	59-68	pancreatic lipase	Homo sapiens	147-164
17478321-6	2007	Fl-labeled clot lysis in ApoE knock-out mice (atherosclerosis model) showed impaired in vivo clot lysis that was "normalized" to wild-type control levels by treatment with alcohol, catechin, or quercetin for 6 to 8 weeks.	Catechin	181-189	apolipoprotein E	Mus musculus	25-29
17293380-4	2007	The enzyme kinetics of SULT1A1 allozymes and SULT1E1 were characterized for the polyphenolic substrates apigenin, chrysin, epicatechin, quercetin, and resveratrol.	Catechin	123-134	sulfotransferase family 1E member 1	Homo sapiens	45-52
17293380-8	2007	The polymorphic SULT1A1*2 allozyme exhibited low activity toward apigenin, epicatechin, and resveratrol.	Catechin	75-86	sulfotransferase family 1A member 1	Homo sapiens	16-23
17379255-2	2007	In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the expression of MCP-1 in human endothelial ECV304 cells.	Catechin	53-61	chemokine (C-C motif) ligand 2	Mus musculus	129-134
17440995-0	2007	Green tea catechins upregulate superoxide dismutase and catalase in fruit flies.	Catechin	10-19	Superoxide dismutase 1	Drosophila melanogaster	31-51
17440995-0	2007	Green tea catechins upregulate superoxide dismutase and catalase in fruit flies.	Catechin	10-19	Catalase	Drosophila melanogaster	56-64
17328920-5	2007	Epicatechin conjugated with palmitic acid ((2R,3R)-3",4",5,7-tetrahydroxyflavan-3-yl hexadecanoate, epicatechin-C16) was the strongest inhibitor in DNA polymerase alpha, beta, lambda and angiogenesis assays.	Catechin	0-11	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	148-168
17108060-14	2007	The induction effect of catechins on UGT1A1 seems to be modest and highly variable.	Catechin	24-33	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
17420592-6	2007	Surprisingly, however, recombinant bmST1 showed considerable activity toward 4-nitrocatechol and also gallate esters, although the catechins are not sulfated by this enzyme.	Catechin	131-140	estrogen sulfotransferase	Bombyx mori	35-40
17077187-4	2007	In Caco-2 cells, the most pronounced induction of BCRP expression could be observed after treatment with TBHQ (100 microM), dibenzoylmethane (DBM, 50 microM), and quercetin (25 microM), while green tea component (-)-epicatechin (50 microM) decreased BCRP expression.	Catechin	212-227	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-54
17292331-4	2007	However, chronic administration of catechin but not quercetin significantly reduced plasma homocysteine levels, attenuated the reduction of the hepatic CBS activity, and restored the decreased paraoxonase-1 gene expression and activity induced by chronic hyperhomocysteinemia.	Catechin	35-43	cystathionine beta-synthase	Mus musculus	152-155
17292331-4	2007	However, chronic administration of catechin but not quercetin significantly reduced plasma homocysteine levels, attenuated the reduction of the hepatic CBS activity, and restored the decreased paraoxonase-1 gene expression and activity induced by chronic hyperhomocysteinemia.	Catechin	35-43	paraoxonase 1	Mus musculus	193-206
17286412-5	2007	A sustained activation of the major survival signals AKT/PI-3-kinase and ERK was shown in EC-treated cells, rather than in CGA-exposed cells.	Catechin	90-92	AKT serine/threonine kinase 1	Homo sapiens	53-56
17286412-5	2007	A sustained activation of the major survival signals AKT/PI-3-kinase and ERK was shown in EC-treated cells, rather than in CGA-exposed cells.	Catechin	90-92	mitogen-activated protein kinase 1	Homo sapiens	73-76
17164435-0	2007	(-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells.	Catechin	4-12	Kruppel-like factor 7 (ubiquitous)	Mus musculus	38-59
17164435-0	2007	(-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells.	Catechin	4-12	adiponectin, C1Q and collagen domain containing	Mus musculus	102-113
17164435-5	2007	We found that (-)-catechin enhanced the expression and secretion of adiponectin protein in a dose- and time-dependent manner.	Catechin	14-26	adiponectin, C1Q and collagen domain containing	Mus musculus	68-79
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	26-38	peroxisome proliferator activated receptor gamma	Mus musculus	178-187
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	26-38	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	189-198
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	26-38	stearoyl-Coenzyme A desaturase 1	Mus musculus	209-214
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	30-38	peroxisome proliferator activated receptor gamma	Mus musculus	178-187
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	30-38	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	189-198
17164435-6	2007	Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation.	Catechin	30-38	stearoyl-Coenzyme A desaturase 1	Mus musculus	209-214
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	adiponectin, C1Q and collagen domain containing	Mus musculus	89-100
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	Kruppel-like factor 7 (ubiquitous)	Mus musculus	178-199
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	Kruppel-like factor 7 (ubiquitous)	Mus musculus	201-205
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	adiponectin, C1Q and collagen domain containing	Mus musculus	278-289
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	peroxisome proliferator activated receptor gamma	Mus musculus	346-355
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	357-367
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	73-85	transcription factor AP-2, alpha	Mus musculus	373-376
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	adiponectin, C1Q and collagen domain containing	Mus musculus	89-100
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	Kruppel-like factor 7 (ubiquitous)	Mus musculus	178-199
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	Kruppel-like factor 7 (ubiquitous)	Mus musculus	201-205
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	adiponectin, C1Q and collagen domain containing	Mus musculus	278-289
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	peroxisome proliferator activated receptor gamma	Mus musculus	346-355
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	357-367
17164435-7	2007	In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes.	Catechin	127-139	transcription factor AP-2, alpha	Mus musculus	373-376
17164435-9	2007	Taken together, these data suggest that the upregulation of adiponectin protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells.	Catechin	83-95	adiponectin, C1Q and collagen domain containing	Mus musculus	60-71
17164435-9	2007	Taken together, these data suggest that the upregulation of adiponectin protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells.	Catechin	83-95	Kruppel-like factor 7 (ubiquitous)	Mus musculus	142-146
17286833-8	2007	Experiments with A. thaliana mutants indicated that (+/-)-catechin induces pathogen resistance by up-regulating defense genes via the salicylic acid (SA)/nonexpressor of pathogenesis related protein 1 (NPR1)-dependent pathway.	Catechin	52-66	pathogenesis-related protein 1	Arabidopsis thaliana	170-200
17230588-2	2007	The inhibitory potency was found to increase with the degree of oligomerisation (PA2 &gt; PC1 &gt;&gt; PB1 = PB2 = PB3 = PB4 &gt;&gt; (-)-epicatechin).	Catechin	134-149	proprotein convertase subtilisin/kexin type 1	Homo sapiens	90-93
17230588-2	2007	The inhibitory potency was found to increase with the degree of oligomerisation (PA2 &gt; PC1 &gt;&gt; PB1 = PB2 = PB3 = PB4 &gt;&gt; (-)-epicatechin).	Catechin	134-149	polybromo 1	Homo sapiens	103-106
18061364-2	2007	As a previous study found that catechins could compete with 17-beta-estradiol for binding to estrogen receptor alpha (ERalpha), we asked whether EGCG could regulate ERalpha action.	Catechin	31-40	estrogen receptor 1	Homo sapiens	93-116
18061364-2	2007	As a previous study found that catechins could compete with 17-beta-estradiol for binding to estrogen receptor alpha (ERalpha), we asked whether EGCG could regulate ERalpha action.	Catechin	31-40	estrogen receptor 1	Homo sapiens	118-125
17228868-0	2007	Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site.	Catechin	10-19	DNA topoisomerase II alpha	Homo sapiens	38-48
17228868-2	2007	We determined that the catechins inhibit bacterial DNA gyrase by binding to the ATP binding site of the gyrase B subunit.	Catechin	23-32	DNA topoisomerase II alpha	Homo sapiens	51-61
17014826-4	2007	Among several tea catechins, EGCG was most effective in inducing mPGES-1 expression.	Catechin	18-27	prostaglandin E synthase	Mus musculus	65-72
17014826-12	2007	Induced EGR-1 then stimulated the induction of mPGES-1 gene expression and this effect mechanistically can be linked to the pharmacological or toxicological actions after human exposure to green tea catechins.	Catechin	199-208	early growth response 1	Homo sapiens	8-13
17014826-12	2007	Induced EGR-1 then stimulated the induction of mPGES-1 gene expression and this effect mechanistically can be linked to the pharmacological or toxicological actions after human exposure to green tea catechins.	Catechin	199-208	prostaglandin E synthase	Mus musculus	47-54
17286833-8	2007	Experiments with A. thaliana mutants indicated that (+/-)-catechin induces pathogen resistance by up-regulating defense genes via the salicylic acid (SA)/nonexpressor of pathogenesis related protein 1 (NPR1)-dependent pathway.	Catechin	52-66	regulatory protein (NPR1)	Arabidopsis thaliana	202-206
17164372-12	2006	Four weeks of green tea catechin intervention did not alter the phenotypic indices of CYP1A2, CYP12D6, and CYP12C9, but resulted in a 20% increase (P = 0.01) in the area under the plasma buspirone concentration-time profile, suggesting a small reduction in CYP3A4 activity.	Catechin	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	257-263
17379280-3	2007	This study determined whether polyphenols (catechin and quercetin) activated kinase-signaling cascades that suppress PAI-1 expression and whether this suppression is at the transcription level in human coronary artery endothelial cells (ECs) remains unresolved.	Catechin	43-51	serpin family E member 1	Homo sapiens	117-122
17379280-7	2007	Catechin and quercetin decreased EC PAI-1 mRNA in a time- and dose-dependent manner, reaching a maximum at 4 and 2 h, respectively.	Catechin	0-8	serpin family E member 1	Homo sapiens	36-41
17056012-1	2006	Catechins have recently been reported to increase the cellular content of the hypoxia-inducible factor (HIF)-1alpha within mammalian cells.	Catechin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-115
17164372-0	2006	Effects of repeated green tea catechin administration on human cytochrome P450 activity.	Catechin	30-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-78
17164372-2	2006	We conducted this clinical study to determine the effect of repeated green tea catechin administration on human cytochrome P450 (CYP) enzyme activities.	Catechin	79-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	112-127
17157668-6	2006	In saturation transfer difference experiments, addition of 5.8 micromol/L CD4 to 310 micromol/L EGCG produced strong saturation at the aromatic rings of EGCG, but identical concentrations of (-)-catechin produced much smaller effects, implying EGCG/CD4 binding strong enough to reduce gp120/CD4 binding substantially.	Catechin	195-203	CD4 molecule	Homo sapiens	74-77
17164372-2	2006	We conducted this clinical study to determine the effect of repeated green tea catechin administration on human cytochrome P450 (CYP) enzyme activities.	Catechin	79-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	129-132
16564553-0	2006	(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation.	Catechin	0-12	mitogen-activated protein kinase 8	Homo sapiens	87-90
17157668-3	2006	METHODS: Nuclear magnetic resonance spectroscopy was used to examine the binding of EGCG and control, (-)-catechin, to CD4-IgG2 (PRO 542).	Catechin	102-114	CD4 molecule	Homo sapiens	119-122
17157668-5	2006	RESULTS: Addition of CD4 to EGCG produced a linear decrease in nuclear magnetic resonance signal intensity from EGCG but not from the control, (-)-catechin.	Catechin	143-155	CD4 molecule	Homo sapiens	21-24
17079869-0	2006	Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway.	Catechin	0-9	angiotensinogen	Rattus norvegicus	18-32
17079869-3	2006	The acting mechanisms of the catechins remain to be defined in the proliferation of VSMC induced by Ang II.	Catechin	29-38	angiotensinogen	Rattus norvegicus	100-106
17079869-4	2006	Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC.	Catechin	20-28	angiotensinogen	Rattus norvegicus	134-140
17079869-4	2006	Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC.	Catechin	30-41	angiotensinogen	Rattus norvegicus	134-140
17079869-4	2006	Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC.	Catechin	43-45	angiotensinogen	Rattus norvegicus	134-140
17079869-8	2006	In conclusion, catechins inhibit the Ang II-stimulated VSMC proliferation via the inhibition of the Ang II-stimulated activation of MAPK and activator protein-1 signaling pathways.	Catechin	15-24	angiogenin	Rattus norvegicus	37-40
17079869-8	2006	In conclusion, catechins inhibit the Ang II-stimulated VSMC proliferation via the inhibition of the Ang II-stimulated activation of MAPK and activator protein-1 signaling pathways.	Catechin	15-24	angiotensinogen	Rattus norvegicus	37-43
17079869-8	2006	In conclusion, catechins inhibit the Ang II-stimulated VSMC proliferation via the inhibition of the Ang II-stimulated activation of MAPK and activator protein-1 signaling pathways.	Catechin	15-24	mitogen activated protein kinase 3	Rattus norvegicus	132-136
17103373-4	2006	S100B treatment with quercetin and catechin in THP-1 cells had inhibitory effects on the expression of pro-inflammatory genes and protein levels.	Catechin	35-43	S100 calcium binding protein B	Homo sapiens	0-5
17103373-4	2006	S100B treatment with quercetin and catechin in THP-1 cells had inhibitory effects on the expression of pro-inflammatory genes and protein levels.	Catechin	35-43	GLI family zinc finger 2	Homo sapiens	47-52
17103373-5	2006	Quercetin and catechin could regulate S100B-activated oxidant stress-sensitive pathways through blocking p47phox protein expression.	Catechin	14-22	S100 calcium binding protein B	Homo sapiens	38-43
17103373-5	2006	Quercetin and catechin could regulate S100B-activated oxidant stress-sensitive pathways through blocking p47phox protein expression.	Catechin	14-22	pleckstrin	Homo sapiens	105-108
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Catechin	29-37	S100 calcium binding protein B	Homo sapiens	125-130
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Catechin	29-37	GLI family zinc finger 2	Homo sapiens	134-139
17103373-7	2006	Quercetin and catechin also showed different regulatory abilities on mitogen-activated protein kinase (MAPK) signaling pathways by inhibiting protein expression in S100B-stimulated inflammatory responses in THP-1 cells.	Catechin	14-22	S100 calcium binding protein B	Homo sapiens	164-169
17103373-7	2006	Quercetin and catechin also showed different regulatory abilities on mitogen-activated protein kinase (MAPK) signaling pathways by inhibiting protein expression in S100B-stimulated inflammatory responses in THP-1 cells.	Catechin	14-22	GLI family zinc finger 2	Homo sapiens	207-212
16978655-3	2006	Catechin and epicatechin inhibited 10 microM Abeta (25-35)-induced neuronal cell death at a concentration of 10 microM, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining.	Catechin	0-8	amyloid beta precursor protein	Rattus norvegicus	45-50
16978655-3	2006	Catechin and epicatechin inhibited 10 microM Abeta (25-35)-induced neuronal cell death at a concentration of 10 microM, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining.	Catechin	13-24	amyloid beta precursor protein	Rattus norvegicus	45-50
16978655-4	2006	Catechin and epicatechin inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic calcium concentration ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM.	Catechin	0-8	amyloid beta precursor protein	Rattus norvegicus	45-50
16978655-4	2006	Catechin and epicatechin inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic calcium concentration ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM.	Catechin	13-24	amyloid beta precursor protein	Rattus norvegicus	45-50
16978655-5	2006	Catechin and epicatechin also inhibited glutamate release into medium induced by 10 microM Abeta (25-35), which was measured by HPLC, generation of reactive oxygen species (ROS) and activation of caspase-3.	Catechin	0-8	amyloid beta precursor protein	Rattus norvegicus	91-96
16978655-5	2006	Catechin and epicatechin also inhibited glutamate release into medium induced by 10 microM Abeta (25-35), which was measured by HPLC, generation of reactive oxygen species (ROS) and activation of caspase-3.	Catechin	0-8	caspase 3	Rattus norvegicus	196-205
16978655-5	2006	Catechin and epicatechin also inhibited glutamate release into medium induced by 10 microM Abeta (25-35), which was measured by HPLC, generation of reactive oxygen species (ROS) and activation of caspase-3.	Catechin	13-24	amyloid beta precursor protein	Rattus norvegicus	91-96
16978655-5	2006	Catechin and epicatechin also inhibited glutamate release into medium induced by 10 microM Abeta (25-35), which was measured by HPLC, generation of reactive oxygen species (ROS) and activation of caspase-3.	Catechin	13-24	caspase 3	Rattus norvegicus	196-205
16978655-6	2006	These results suggest that catechin and epicatechin prevent Abeta (25-35)-induced neuronal cell damage by interfering with the increase of [Ca2+]c, and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.	Catechin	27-35	amyloid beta precursor protein	Rattus norvegicus	60-65
16978655-6	2006	These results suggest that catechin and epicatechin prevent Abeta (25-35)-induced neuronal cell damage by interfering with the increase of [Ca2+]c, and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.	Catechin	27-35	caspase 3	Rattus norvegicus	212-221
16978655-6	2006	These results suggest that catechin and epicatechin prevent Abeta (25-35)-induced neuronal cell damage by interfering with the increase of [Ca2+]c, and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.	Catechin	40-51	amyloid beta precursor protein	Rattus norvegicus	60-65
16978655-6	2006	These results suggest that catechin and epicatechin prevent Abeta (25-35)-induced neuronal cell damage by interfering with the increase of [Ca2+]c, and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.	Catechin	40-51	caspase 3	Rattus norvegicus	212-221
17016658-3	2006	In this study, we investigated the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the PDGF-induced VEGF expression in hVSMCs and the underlying mechanisms.	Catechin	53-61	vascular endothelial growth factor A	Homo sapiens	130-134
17073579-7	2006	It has been also found that efflux transporters Pgp, MRP1 and MRP2 play roles in the absorption and excretion of green tea catechins.	Catechin	123-132	phosphoglycolate phosphatase	Homo sapiens	48-51
17073579-7	2006	It has been also found that efflux transporters Pgp, MRP1 and MRP2 play roles in the absorption and excretion of green tea catechins.	Catechin	123-132	ATP binding cassette subfamily C member 1	Homo sapiens	53-57
17073579-7	2006	It has been also found that efflux transporters Pgp, MRP1 and MRP2 play roles in the absorption and excretion of green tea catechins.	Catechin	123-132	ATP binding cassette subfamily C member 2	Homo sapiens	62-66
17015253-2	2006	Previously, we described that ( - )-epicatechin (EC) inhibits PMA-induced NF-kappaB activation in Jurkat T cells.	Catechin	30-47	nuclear factor kappa B subunit 1	Homo sapiens	74-83
17015253-2	2006	Previously, we described that ( - )-epicatechin (EC) inhibits PMA-induced NF-kappaB activation in Jurkat T cells.	Catechin	49-51	nuclear factor kappa B subunit 1	Homo sapiens	74-83
17015253-4	2006	EC inhibited NF-kappaB-DNA binding activity in L-428 and KM-H2 cells.	Catechin	0-2	nuclear factor kappa B subunit 1	Homo sapiens	13-22
17015253-7	2006	The combined treatment with EC and an inhibitor of NF-kappaB nuclear translocation (SN-50) caused an additive inhibitory effect on NF-kappaB activation.	Catechin	28-30	nuclear factor kappa B subunit 1	Homo sapiens	51-60
17015253-7	2006	The combined treatment with EC and an inhibitor of NF-kappaB nuclear translocation (SN-50) caused an additive inhibitory effect on NF-kappaB activation.	Catechin	28-30	nuclear factor kappa B subunit 1	Homo sapiens	131-140
17015253-8	2006	The partial cell viability decrease, under conditions that EC and SN-50 completely prevented NF-kappaB-DNA binding, indicates that the inhibition of other signaling pathways should be also targeted in the treatment of Hodgkin"s lymphoma.	Catechin	59-61	nuclear factor kappa B subunit 1	Homo sapiens	93-102
16522360-0	2006	Isothermal titration calorimetry study of epicatechin binding to serum albumin.	Catechin	42-53	albumin	Homo sapiens	65-78
16522360-1	2006	The interaction of epicatechin with bovine serum albumin (BSA) was studied by isothermal titration calorimetry.	Catechin	19-30	albumin	Homo sapiens	43-56
16564553-9	2006	(+)-Catechin also inhibited UVB- and H2O2-induced JNK activation in keratinocytes.	Catechin	0-12	mitogen-activated protein kinase 8	Homo sapiens	50-53
16564553-13	2006	Taken together, our results demonstrate that (+)-catechin inhibits UVB- and oxidative stress-induced H2O2 production and JNK activation and enhances human keratinocyte survival.	Catechin	45-57	mitogen-activated protein kinase 8	Homo sapiens	121-124
16597367-5	2006	We have also shown that the combination of epicatechin, epigallocatechin and epigallocatechingallate with caffeine, theobromine or theophylline induced cellular neutral endopeptidase activity.	Catechin	43-54	membrane metalloendopeptidase	Homo sapiens	161-182
16770007-8	2006	Treatment of platelets with quercetin and catechin resulted in an increase of NO and also down-regulated the expression of GpIIb/IIIa glycoprotein.	Catechin	42-50	integrin subunit alpha 2b	Homo sapiens	123-128
16217757-0	2006	Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex.	Catechin	10-18	vascular endothelial growth factor A	Homo sapiens	57-91
16217757-2	2006	We have shown previously that the green tea catechin, epigallocatechin gallate (EGCG), inhibits endothelial cell tube formation through the inhibition of vascular endothelial growth factor (VEGF)-induced Akt activation and vascular endothelial (VE)-cadherin phosphorylation.	Catechin	44-52	vascular endothelial growth factor A	Homo sapiens	154-188
16217757-2	2006	We have shown previously that the green tea catechin, epigallocatechin gallate (EGCG), inhibits endothelial cell tube formation through the inhibition of vascular endothelial growth factor (VEGF)-induced Akt activation and vascular endothelial (VE)-cadherin phosphorylation.	Catechin	44-52	vascular endothelial growth factor A	Homo sapiens	190-194
16217757-2	2006	We have shown previously that the green tea catechin, epigallocatechin gallate (EGCG), inhibits endothelial cell tube formation through the inhibition of vascular endothelial growth factor (VEGF)-induced Akt activation and vascular endothelial (VE)-cadherin phosphorylation.	Catechin	44-52	AKT serine/threonine kinase 1	Homo sapiens	204-207
16217757-2	2006	We have shown previously that the green tea catechin, epigallocatechin gallate (EGCG), inhibits endothelial cell tube formation through the inhibition of vascular endothelial growth factor (VEGF)-induced Akt activation and vascular endothelial (VE)-cadherin phosphorylation.	Catechin	44-52	cadherin 5	Homo sapiens	223-257
16704229-0	2006	Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor.	Catechin	7-15	sucrase-isomaltase	Homo sapiens	78-95
16704229-1	2006	Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.	Catechin	7-15	sucrase-isomaltase	Homo sapiens	133-150
16314398-0	2006	Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling.	Catechin	71-79	tumor necrosis factor receptor superfamily, member 25	Mus musculus	113-118
16314398-5	2006	Since it is known that Green Tea Catechin (GTC) administration to TRAMP mice results in a substantial delay of CaP progression in 80% of the animals, while 20% remain unresponsive, we determined the 8-gene signature in the prostates of GTC-sensitive and GTC-resistant mice.	Catechin	33-41	tumor necrosis factor receptor superfamily, member 25	Mus musculus	66-71
16415120-6	2006	Moreover, flavonol glycosides and catechins significantly inhibited the function of OATP-B, suggesting that the inhibitory effects of the herbal extracts on OATP-B may be primarily attributable to flavonoids.	Catechin	34-43	solute carrier organic anion transporter family member 2B1	Homo sapiens	84-90
16415120-6	2006	Moreover, flavonol glycosides and catechins significantly inhibited the function of OATP-B, suggesting that the inhibitory effects of the herbal extracts on OATP-B may be primarily attributable to flavonoids.	Catechin	34-43	solute carrier organic anion transporter family member 2B1	Homo sapiens	157-163
16608395-1	2006	A cancer-specific cell surface protein, tNOX, has been identified as a target for low-dose cell killing (apoptosis) of cancer cells by green tea catechins and Capsicum vanilloid combinations.	Catechin	145-154	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	40-44
16608395-5	2006	Among the most potent and effective inhibitors of tNOX are naturally occurring polyphenols exemplified by the principal green tea catechin (-)-epigallocatechin gallate (EGCg) and the vanilloid capsaicin.	Catechin	130-138	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	50-54
16608395-7	2006	Vector-forced overexpression of tNOX cDNA and antisense has demonstrated that the tNOX target is both necessary and sufficient to explain the anticancer properties of green tea catechins alone and in vanilloid-containing combinations.	Catechin	177-186	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	32-36
16608395-7	2006	Vector-forced overexpression of tNOX cDNA and antisense has demonstrated that the tNOX target is both necessary and sufficient to explain the anticancer properties of green tea catechins alone and in vanilloid-containing combinations.	Catechin	177-186	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	82-86
16608395-8	2006	The necessity and sufficiency of tNOX was validated as the catechin target with transgenic mice overexpressing the processed form of tNOX.	Catechin	59-67	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	33-37
16608395-8	2006	The necessity and sufficiency of tNOX was validated as the catechin target with transgenic mice overexpressing the processed form of tNOX.	Catechin	59-67	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	133-137
16608395-10	2006	A catechin-vanilloid mixture where one 350-mg capsule is equivalent to 16 cups of green tea in its ability to inhibit tNOX and growth of cancer cells in culture is undergoing clinical evaluation as a therapeutic aid for cancer patients.	Catechin	2-10	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	118-122
16449979-0	2006	The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.	Catechin	14-23	hepatocyte growth factor	Homo sapiens	108-111
16449979-7	2006	We assessed the ability of alternative green tea catechins to inhibit HGF-induced signaling and motility.	Catechin	49-58	hepatocyte growth factor	Homo sapiens	70-73
16458870-4	2006	In our preliminary study, we investigated the effect of flavonoids including luteolin, quercetin, baicalein, genistein, taxifolin and catechin on HGF-mediated migration and invasion of HepG2 cells.	Catechin	134-142	hepatocyte growth factor	Homo sapiens	146-149
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	Catechin	27-29	hepatocyte growth factor	Homo sapiens	82-85
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	Catechin	27-29	hepatocyte growth factor	Homo sapiens	219-222
16449979-11	2006	These observations suggest that the R1 galloyl and the R2 hydroxyl groups are important in mediating the green tea catechins" inhibitory effect towards HGF/Met signaling.	Catechin	115-124	hepatocyte growth factor	Homo sapiens	152-155
16522169-4	2006	A dose-related effect of blueberry, green tea, catechin, carnosine, and vitamin D(3) was observed on proliferation with human bone marrow as compared with human granulocyte-macrophage colony-stimulating factor (hGM-CSF).	Catechin	47-55	colony stimulating factor 2	Homo sapiens	161-209
16413020-6	2006	In this case, caspase-3 activity in the cytoplasm, the serum aminotransferases and dUTP nick formation detected by TUNNEL-staining were effects, and these elevations were suppressed by administration of catechin.	Catechin	203-211	caspase 3	Homo sapiens	14-23
16460233-4	2006	Catechin conjugated with stearic acid [(2R,3S)-3",4",5,7-tetrahydroxyflavan-3-yl octadecanoate; catechin-C18] was the strongest inhibitor in DNA polymerase alpha and beta and angiogenesis assays.	Catechin	0-8	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	141-161
16330143-4	2006	In this study, we further characterized epicatechin monomer, dimer, tetramer and hexamer ACE inhibitory effect, by performing fluorescence quenching and kinetic assays, using angiotensin I as substrate.	Catechin	40-51	angiotensin I converting enzyme	Homo sapiens	89-92
16330143-4	2006	In this study, we further characterized epicatechin monomer, dimer, tetramer and hexamer ACE inhibitory effect, by performing fluorescence quenching and kinetic assays, using angiotensin I as substrate.	Catechin	40-51	angiotensinogen	Homo sapiens	175-188
16109389-0	2006	Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts.	Catechin	4-13	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
16109389-1	2006	OBJECTIVE: Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors.	Catechin	15-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
16109389-5	2006	Although severe myocardial cell infiltration, fibrosis, and GAD with enhancement of inflammatory factors were observed in untreated class II mismatch allografts at day 60, catechins attenuated these changes with altered Th1/Th2 cytokine balance and suppressed NF-kappaB activation and cell proliferation.	Catechin	172-181	negative elongation factor complex member C/D, Th1l	Mus musculus	220-223
16109389-5	2006	Although severe myocardial cell infiltration, fibrosis, and GAD with enhancement of inflammatory factors were observed in untreated class II mismatch allografts at day 60, catechins attenuated these changes with altered Th1/Th2 cytokine balance and suppressed NF-kappaB activation and cell proliferation.	Catechin	172-181	heart and neural crest derivatives expressed 2	Mus musculus	224-227
16314917-1	2005	Catechins are able to modulate the gelatinolytic activity of matrix metalloproteinase-9 (MMP-9) by reducing its release from macrophages.	Catechin	0-9	matrix metallopeptidase 9	Homo sapiens	61-87
16753784-6	2006	(+)-Catechin partially inhibited the activation of caspase-3, thereby both cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD) were effectively abolished.	Catechin	0-12	caspase 3	Mus musculus	51-60
16753784-6	2006	(+)-Catechin partially inhibited the activation of caspase-3, thereby both cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD) were effectively abolished.	Catechin	0-12	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-115
16753784-6	2006	(+)-Catechin partially inhibited the activation of caspase-3, thereby both cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD) were effectively abolished.	Catechin	0-12	poly (ADP-ribose) polymerase family, member 1	Mus musculus	117-121
16753784-6	2006	(+)-Catechin partially inhibited the activation of caspase-3, thereby both cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD) were effectively abolished.	Catechin	0-12	DNA fragmentation factor, beta subunit	Mus musculus	155-178
16753784-6	2006	(+)-Catechin partially inhibited the activation of caspase-3, thereby both cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD) were effectively abolished.	Catechin	0-12	DNA fragmentation factor, alpha subunit	Mus musculus	180-184
16753784-7	2006	In addition, the expression of PARP for repair of impaired DNA was significantly increased by (+)-catechin treatment.	Catechin	94-106	poly (ADP-ribose) polymerase family, member 1	Mus musculus	31-35
16753784-8	2006	Taken together, these data suggest that protective effects of (+)-catechin against oxidative DNA damage of microglia cells is exerted by the increased expression of DNA repair enzyme PARP and antioxidant enzyme activities.	Catechin	62-74	poly (ADP-ribose) polymerase family, member 1	Mus musculus	183-187
16314917-1	2005	Catechins are able to modulate the gelatinolytic activity of matrix metalloproteinase-9 (MMP-9) by reducing its release from macrophages.	Catechin	0-9	matrix metallopeptidase 9	Homo sapiens	89-94
16037419-1	2005	In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1.	Catechin	79-88	DNA methyltransferase 1	Homo sapiens	156-177
16243908-3	2005	The tt10 mutant seeds accumulate more epicatechin monomers and more soluble proanthocyanidins than wild-type seeds.	Catechin	38-49	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	4-8
16216226-10	2005	Collectively, these results suggest that the gallate-ester moiety of epicatechins may be critical for inhibiting the K(ATP) channel activity via the pore-forming subunit Kir6.2 and this may be a possible mechanism by which green tea extracts or EGCG may cause unexpected side effects at micromolar plasma level.	Catechin	69-81	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	170-176
16220062-8	2005	An increase in the number of gallate groups per catechin molecule was associated with increased inhibition of angiotensin II-dependent collagen gel contraction by SMC.	Catechin	48-56	angiotensinogen	Homo sapiens	110-124
16037419-1	2005	In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1.	Catechin	79-88	DNA methyltransferase 1	Homo sapiens	179-183
15860507-9	2005	Further, (-)-epicatechin-3-gallate (25 and 100 microM) and green tea polyphenols (33 and 132 microg/ml) induced pro-MMP-7 expression, whereas (-)-epicatechin and (-)-epigallocatechin (100 microM each) did not.	Catechin	9-24	matrix metallopeptidase 7	Homo sapiens	116-121
16270650-0	2005	The polyphenols quercetin and catechin synergize in inhibiting platelet CD40L expression.	Catechin	30-38	CD40 ligand	Homo sapiens	72-77
15860507-11	2005	Our results suggest that some green tea catechins induce pro-MMP-7 production via O2- production and the activation of JNK1/2, c-JUN, c-FOS and AP-1 in HT-29 cells.	Catechin	40-49	matrix metallopeptidase 7	Homo sapiens	61-66
15860507-11	2005	Our results suggest that some green tea catechins induce pro-MMP-7 production via O2- production and the activation of JNK1/2, c-JUN, c-FOS and AP-1 in HT-29 cells.	Catechin	40-49	mitogen-activated protein kinase 8	Homo sapiens	119-125
15860507-11	2005	Our results suggest that some green tea catechins induce pro-MMP-7 production via O2- production and the activation of JNK1/2, c-JUN, c-FOS and AP-1 in HT-29 cells.	Catechin	40-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
15860507-11	2005	Our results suggest that some green tea catechins induce pro-MMP-7 production via O2- production and the activation of JNK1/2, c-JUN, c-FOS and AP-1 in HT-29 cells.	Catechin	40-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
15860507-11	2005	Our results suggest that some green tea catechins induce pro-MMP-7 production via O2- production and the activation of JNK1/2, c-JUN, c-FOS and AP-1 in HT-29 cells.	Catechin	40-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-148
15885676-0	2005	Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression.	Catechin	0-9	matrix metallopeptidase 14	Homo sapiens	69-76
16227644-2	2005	Intraperitoneal administration of (-)-epicatechin at doses of 15 and 30 mg/kg to diabetic rats for a period of 35 days resulted in a significant decrease in blood glucose, thiobarbituric acid reactive substances and hydroperoxides and a significant increase in the concentration of glutathione and the activities of catalase, superoxide dismutase and glutathione peroxidase.	Catechin	34-49	catalase	Rattus norvegicus	316-324
16104819-12	2005	EGCG acts in blood physiological concentrations (micromolar range), and catechin acts in higher gut-relevant concentrations (millimolar range) and has the potential to influence the proinflammatory TNFalpha expression.	Catechin	72-80	tumor necrosis factor	Bos taurus	198-206
16104819-13	2005	Higher flavanoid concentration had more pronounced effects than lower, whereas EGCG showed a more potent suppression of gene expression than catechin (toward TNFalpha).	Catechin	141-149	tumor necrosis factor	Bos taurus	158-166
15885676-0	2005	Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression.	Catechin	0-9	matrix metallopeptidase 2	Homo sapiens	90-95
16149735-5	2005	Physiological concentrations of catechin and quercetin offered similar levels of protection against modification by carbonyls of the apoB-100 at advanced stages (carbonyls approximately 96.0 nmol/mg LDL protein) but not at the intermediate stages (carbonyls approximately 58.0 nmol/mg LDL protein) of LDL oxidation probably owing to differences in the protein-binding mechanisms of catechin and quercetin.	Catechin	32-40	apolipoprotein B	Homo sapiens	133-141
15992376-0	2005	Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.	Catechin	146-154	ras homolog family member A	Homo sapiens	66-70
15992376-0	2005	Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.	Catechin	146-154	CD44 molecule (Indian blood group)	Homo sapiens	84-88
15992376-6	2005	Treatment of glioma cells with the Rho-kinase (ROK) inhibitor Y27632, or with EGCg, a green tea catechin with anti-MMP and anti-angiogenesis activities, antagonized both RhoA- and MT1-MMP-induced CD44 shedding.	Catechin	96-104	ras homolog family member A	Homo sapiens	170-174
16149735-5	2005	Physiological concentrations of catechin and quercetin offered similar levels of protection against modification by carbonyls of the apoB-100 at advanced stages (carbonyls approximately 96.0 nmol/mg LDL protein) but not at the intermediate stages (carbonyls approximately 58.0 nmol/mg LDL protein) of LDL oxidation probably owing to differences in the protein-binding mechanisms of catechin and quercetin.	Catechin	382-390	apolipoprotein B	Homo sapiens	133-141
15895994-0	2005	Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies.	Catechin	74-83	dihydrofolate reductase	Bos taurus	43-66
15968412-0	2005	Green tea catechins containing a galloyl group in the 3" position inhibit tissue factor-induced thrombin generation.	Catechin	10-19	coagulation factor II, thrombin	Homo sapiens	96-104
15832299-5	2005	While for catechin and epicatechin the first ionizable OH group occurs in ring 1 and the second ionizable group in ring 2, in flavonols the first deprotonation occurs in ring 2 and the second in ring 1.	Catechin	10-18	ring finger protein 1	Homo sapiens	74-80
15974445-5	2005	On immunomodulatory properties, catechin, epigallocatechin (EGC), naringenin, and fisetin repressed NO production and TNF-alpha secretion.	Catechin	32-40	tumor necrosis factor	Homo sapiens	118-127
15974445-6	2005	Furthermore, catechin, epigallocatechin gallate (EGCG), epicatechin (EC), luteolin, chrysin, quercetin, and galangin increased IL-2 secretion while EGC, apigenin, and fisetin inhibited the secretion.	Catechin	13-21	interleukin 2	Homo sapiens	127-131
15974445-6	2005	Furthermore, catechin, epigallocatechin gallate (EGCG), epicatechin (EC), luteolin, chrysin, quercetin, and galangin increased IL-2 secretion while EGC, apigenin, and fisetin inhibited the secretion.	Catechin	56-67	interleukin 2	Homo sapiens	127-131
15974445-6	2005	Furthermore, catechin, epigallocatechin gallate (EGCG), epicatechin (EC), luteolin, chrysin, quercetin, and galangin increased IL-2 secretion while EGC, apigenin, and fisetin inhibited the secretion.	Catechin	69-71	interleukin 2	Homo sapiens	127-131
15857617-0	2005	Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies.	Catechin	62-71	catechol-O-methyltransferase	Homo sapiens	26-54
15857617-3	2005	We now report the structure-activity relationship for the inhibition of COMT-catalyzed O-methylation of catecholestrogens in human liver cytosol by tea catechins and some of their metabolites.	Catechin	152-161	catechol-O-methyltransferase	Homo sapiens	72-76
15857617-11	2005	These results provide mechanistic insight into the inhibition of COMT by commonly consumed tea catechins.	Catechin	95-104	catechol-O-methyltransferase	Homo sapiens	65-69
15914933-2	2005	The activities of fatty acid synthase and the malic enzyme in the liver cytosol were significantly lower in the two catechin groups than in the control group.	Catechin	116-124	fatty acid synthase	Rattus norvegicus	18-37
15832299-5	2005	While for catechin and epicatechin the first ionizable OH group occurs in ring 1 and the second ionizable group in ring 2, in flavonols the first deprotonation occurs in ring 2 and the second in ring 1.	Catechin	23-34	ring finger protein 1	Homo sapiens	74-80
15725512-9	2005	Malondialdehyde, glutathione peroxidase and catalase activities were decreased in the vitamin E+doxorubicin- and catechin+doxorubicin-treated group compared to doxorubicin-treated group (P&lt;0.05).	Catechin	113-121	catalase	Rattus norvegicus	44-52
15879681-6	2005	Results of flow cytometric analysis showed that the amount of intracellular *OH was decreased, and the cell cycle arrest was reversed by down-regulation of p53 phosphorylation after treatment with (+)-catechin.	Catechin	197-209	transformation related protein 53, pseudogene	Mus musculus	156-159
15879681-9	2005	Taken together, (+)-catechin inhibited tBHP-induced translocation of NF-kappaB to improve cellular survival.	Catechin	16-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
15748600-4	2005	In vitro effect of tea catechins was studied by incubating membrane/intact erythrocytes in assay medium prior to Na(+)/K(+)-ATPase/NHE activity determination.	Catechin	23-32	solute carrier family 9 member C1	Homo sapiens	131-134
15748600-6	2005	Tea catechins inhibited the activity of Na(+)/K(+)-ATPase and NHE in both normal and NIDDM erythrocytes, the effect was concentration-dependent.	Catechin	4-13	solute carrier family 9 member C1	Homo sapiens	62-65
15748600-8	2005	On NHE the inhibition of tea catechins was in the order: EC&gt;EGC&gt;ECG&gt;EGCG at concentrations up to 10 micromol/l.	Catechin	29-38	solute carrier family 9 member C1	Homo sapiens	3-6
15748600-10	2005	The effect of tea catechins on Na(+)/K(+)-ATPase and NHE may be explained due to a direct effect of these compounds on plasma membrane leading to a change in membrane fluidity.	Catechin	18-27	solute carrier family 9 member C1	Homo sapiens	53-56
15664813-0	2005	Synthesis of modified proanthocyanidins: easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol.	Catechin	100-108	complement C6	Homo sapiens	93-96
15740021-2	2005	Significant increase in neuronal cell death was observed on PC12 cells treated with Abeta(25)(-)(35) (25 microM), while epicatechin and catechin and their mixture prevented the Abeta-induced neuronal cell death.	Catechin	120-131	amyloid beta precursor protein	Rattus norvegicus	177-182
15740021-2	2005	Significant increase in neuronal cell death was observed on PC12 cells treated with Abeta(25)(-)(35) (25 microM), while epicatechin and catechin and their mixture prevented the Abeta-induced neuronal cell death.	Catechin	123-131	amyloid beta precursor protein	Rattus norvegicus	177-182
15740021-4	2005	The membrane protective effects of the phenolics determined by LDH release and trypan blue exclusion assays demonstrated that epicatechin, catechin, and their mixture protect cellular membrane from Abeta-induced cytotoxicity.	Catechin	126-137	amyloid beta precursor protein	Rattus norvegicus	198-203
15740021-4	2005	The membrane protective effects of the phenolics determined by LDH release and trypan blue exclusion assays demonstrated that epicatechin, catechin, and their mixture protect cellular membrane from Abeta-induced cytotoxicity.	Catechin	129-137	amyloid beta precursor protein	Rattus norvegicus	198-203
15740021-6	2005	The present results showed that the major flavonoids of cocoa, epicatechin and catechin, protect PC12 cells from Abeta-induced neurotoxicity, and suggest that cocoa may have anti-neurodegenerative effect in addition to other known chemopreventive effects.	Catechin	63-74	amyloid beta precursor protein	Rattus norvegicus	113-118
15740021-6	2005	The present results showed that the major flavonoids of cocoa, epicatechin and catechin, protect PC12 cells from Abeta-induced neurotoxicity, and suggest that cocoa may have anti-neurodegenerative effect in addition to other known chemopreventive effects.	Catechin	66-74	amyloid beta precursor protein	Rattus norvegicus	113-118
15649637-4	2005	For the HGF-2 fibroblasts, ECG and CG grouped as highly toxic, EGCG as moderately toxic, and EGC, C, and EC as least toxic.	Catechin	27-29	GINGF2	Homo sapiens	8-13
15664813-1	2005	A general procedure for the oxidation of catechin derivatives is described, leading to the introduction of a new hydroxy group at C-6.	Catechin	41-49	complement C6	Homo sapiens	130-133
15656669-4	2005	We have attempted to enrich the cellular TRX content in Saccharomyces cerevisiae, and found that green tea extract (Sunphenon), which is rich in catechins (polyphenols), activates the Yap1 transcription factor, leading to the induction of TRX2, a target of Yap1.	Catechin	145-154	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	184-188
15671206-6	2005	These catechin preparations dose-dependently inhibited the activity of pancreatic lipase in vitro.	Catechin	6-14	pancreatic lipase	Rattus norvegicus	71-88
15671206-7	2005	When purified catechins were used, only those with a galloyl moiety inhibited the activity of pancreatic lipase.	Catechin	14-23	pancreatic lipase	Rattus norvegicus	94-111
15671206-8	2005	These results suggest that catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by slowing down triacylglycerol absorption through the inhibition of pancreatic lipase.	Catechin	27-36	pancreatic lipase	Rattus norvegicus	175-192
15635163-7	2005	Epicatechin stimulated catalase, GPX and glutathion content, but not SOD.	Catechin	0-11	catalase	Mus musculus	23-31
15631523-1	2005	The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching.	Catechin	41-49	albumin	Homo sapiens	97-116
15631523-1	2005	The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching.	Catechin	51-62	albumin	Homo sapiens	97-116
15620252-5	2004	Among the green tea catechins tested, 1 demonstrated the strongest HIF-1-inducing activity, while (-)-epigallocatechin-3-gallate (EGCG, 2) was significantly less active.	Catechin	20-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
15541906-5	2004	However, significant efflux mediated by MRP was observed during the secretion of GTC, especially the non-gallated catechins.	Catechin	114-123	ATP binding cassette subfamily C member 1	Homo sapiens	40-43
15683997-0	2005	[Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis].	Catechin	41-49	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	53-69
15683997-1	2005	OBJECTIVE: To examine the effect of combined use of curcumin and catechin on the number of aberrant crypt foci (ACF) and expression levels of cyclooxygenase-2 (COX-2) mRNA in rat colon carcinogenesis.	Catechin	65-73	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	142-158
15683997-6	2005	A synergistic inhibitory effect between curcumin and catechin on the expression of COX-2 mRNA was observed in the early stage of rat colon carcinogenesis but not in colon tumor tissues.	Catechin	53-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	83-88
15683997-7	2005	CONCLUSION: Curcumin and catechin have synergistic effect on ACF and COX-2 mRNA expression in rat colon carcinogenesis, suggesting their potential value in the prevention of human colon cancers.	Catechin	25-33	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	69-74
15620252-10	2004	These results suggest that intended cancer chemoprevention with high-dose green tea extracts may be compromised, by the ability of tea catechins to promote tumor cell survival pathways associated with HIF-1 activation.	Catechin	135-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-206
15546559-1	2004	BACKGROUND: We hypothesized that combined treatment with cyclooxygenase (Cox)-1 (catechin) and Cox-2 (NS398)-specific inhibitors would reduce cellular proliferation synergistically in genitourinary cancer.	Catechin	81-89	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	73-79
15450943-0	2004	Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.	Catechin	22-33	interleukin 1 beta	Rattus norvegicus	37-54
15450943-0	2004	Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.	Catechin	22-33	nitric oxide synthase 2	Rattus norvegicus	63-94
15450943-5	2004	In the present study, the effects of epicatechin on IL-1beta-induced beta-cell damage were examined.	Catechin	37-48	interleukin 1 beta	Rattus norvegicus	52-60
15450943-11	2004	Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity.	Catechin	0-11	interleukin 1 beta	Rattus norvegicus	34-42
15450943-11	2004	Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity.	Catechin	0-11	nitric oxide synthase 2	Rattus norvegicus	71-75
15450943-11	2004	Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity.	Catechin	0-11	interleukin 1 beta	Rattus norvegicus	128-136
15450943-11	2004	Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity.	Catechin	0-11	NFKB inhibitor alpha	Rattus norvegicus	145-157
15450943-11	2004	Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity.	Catechin	0-11	nitric oxide synthase 2	Rattus norvegicus	205-209
15450943-12	2004	Epicatechin partly restored the IL-1beta-induced inhibition of insulin release.	Catechin	0-11	interleukin 1 beta	Rattus norvegicus	32-40
15450943-13	2004	These results suggest that epicatechin inhibits the IL-1beta-induced iNOS expression by down-regulating NF-kappaB activation, and protecting beta-cells from IL-1beta.	Catechin	27-38	interleukin 1 beta	Rattus norvegicus	52-60
15450943-13	2004	These results suggest that epicatechin inhibits the IL-1beta-induced iNOS expression by down-regulating NF-kappaB activation, and protecting beta-cells from IL-1beta.	Catechin	27-38	nitric oxide synthase 2	Rattus norvegicus	69-73
15450943-13	2004	These results suggest that epicatechin inhibits the IL-1beta-induced iNOS expression by down-regulating NF-kappaB activation, and protecting beta-cells from IL-1beta.	Catechin	27-38	interleukin 1 beta	Rattus norvegicus	157-165
15564676-0	2004	Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells.	Catechin	4-12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
15331156-0	2004	Catechins prevents substance P-induced hyperactive bladder in rats via the downregulation of ICAM and ROS.	Catechin	0-9	intercellular adhesion molecule 1	Rattus norvegicus	93-97
15564676-0	2004	Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells.	Catechin	4-12	peroxisome proliferator activated receptor gamma	Mus musculus	84-94
15564676-0	2004	Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells.	Catechin	4-12	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	99-109
15564676-5	2004	These catechins inhibited the expression of peroxisome proliferator-activated receptor (PPAR) gamma2 and CCAAT/enhancer-binding protein (C/EBP) alpha, both of which act as key transcription factors at an early stage of differentiation, followed by the expression of glucose transporter (GLUT) 4 at a later stage.	Catechin	6-15	peroxisome proliferator activated receptor gamma	Mus musculus	44-100
15564676-5	2004	These catechins inhibited the expression of peroxisome proliferator-activated receptor (PPAR) gamma2 and CCAAT/enhancer-binding protein (C/EBP) alpha, both of which act as key transcription factors at an early stage of differentiation, followed by the expression of glucose transporter (GLUT) 4 at a later stage.	Catechin	6-15	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	137-149
15564676-5	2004	These catechins inhibited the expression of peroxisome proliferator-activated receptor (PPAR) gamma2 and CCAAT/enhancer-binding protein (C/EBP) alpha, both of which act as key transcription factors at an early stage of differentiation, followed by the expression of glucose transporter (GLUT) 4 at a later stage.	Catechin	6-15	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	266-294
15564676-7	2004	Thus, catechin suppressed adipocyte differentiation accompanied by the down-regulation of PPARgamma2, C/EBPalpha, and GLUT4.	Catechin	6-14	peroxisome proliferator activated receptor gamma	Mus musculus	90-100
15564676-7	2004	Thus, catechin suppressed adipocyte differentiation accompanied by the down-regulation of PPARgamma2, C/EBPalpha, and GLUT4.	Catechin	6-14	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	102-112
15564676-7	2004	Thus, catechin suppressed adipocyte differentiation accompanied by the down-regulation of PPARgamma2, C/EBPalpha, and GLUT4.	Catechin	6-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	118-123
15564676-8	2004	These results suggest that tea catechin prevents obesity through the suppression of adipocyte differentiation.	Catechin	31-39	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	27-30
15380193-0	2004	Novel epicatechin derivatives with antioxidant activity modulate interleukin-1beta release in lipopolysaccharide-stimulated human blood.	Catechin	6-17	interleukin 1 beta	Homo sapiens	65-82
15380193-5	2004	At concentrations up to 20 microM, epicatechin and its derivatives inhibited the production of IL-1beta in whole blood incubated in the presence of E. coli lipopolysaccharide (LPS), in a concentration-dependent manner.	Catechin	35-46	interleukin 1 beta	Homo sapiens	95-103
15457130-2	2004	The aim of this work was to determine if low concentrations of catechins with and without 4-hydroxytamoxifen (4-OHT) co-treatment would cause significant cytotoxicity in estrogen receptor-positive (ERalpha+) and -negative (ERalpha-) human breast cancer cells.	Catechin	63-72	estrogen receptor 1	Homo sapiens	223-230
15457130-7	2004	ERalpha- human breast cancer cells were more susceptible as all three catechins were significantly cytotoxic to HS578T cells at concentrations of 10 microM.	Catechin	70-79	estrogen receptor 1	Homo sapiens	0-7
15457130-11	2004	In conclusion, low concentrations of catechins are cytotoxic to ERalpha- human breast cancer cells, and the combination of EGCG and 4-OHT elicits synergistic cytotoxicity in MDA-MB-231 cells.	Catechin	37-46	estrogen receptor 1	Homo sapiens	64-71
15358631-0	2004	The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression.	Catechin	30-39	clusterin	Mus musculus	110-119
15568761-4	2004	In this study we show that other red wine constituents, namely, the catechins (2, 3) and epicatechins (4, 5), act as peroxidase mediated mechanism-based inactivators of COX-1 but not of COX-2.	Catechin	68-77	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	169-174
15568761-4	2004	In this study we show that other red wine constituents, namely, the catechins (2, 3) and epicatechins (4, 5), act as peroxidase mediated mechanism-based inactivators of COX-1 but not of COX-2.	Catechin	89-101	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	169-174
15457130-2	2004	The aim of this work was to determine if low concentrations of catechins with and without 4-hydroxytamoxifen (4-OHT) co-treatment would cause significant cytotoxicity in estrogen receptor-positive (ERalpha+) and -negative (ERalpha-) human breast cancer cells.	Catechin	63-72	estrogen receptor 1	Homo sapiens	198-205
15340218-9	2004	These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation.	Catechin	46-55	interleukin 12b	Mus musculus	97-105
15340218-0	2004	Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1.	Catechin	18-27	interleukin 12b	Mus musculus	35-43
15340218-9	2004	These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation.	Catechin	46-55	mitogen-activated protein kinase 14	Mus musculus	153-161
15340218-3	2004	We investigated the effect of catechins on IL-12p40 production in murine macrophages induced by bacterial lipopolysaccharide (LPS).	Catechin	30-39	interleukin 12b	Mus musculus	43-51
15340218-4	2004	Pretreatment with several catechins at doses of 0.3-30 microM suppressed IL-12 p40 production by murine peritoneal exudate cells (PEC) and J774.1 cells in a dose-dependent manner.	Catechin	26-35	interleukin 12b	Mus musculus	73-82
15340218-9	2004	These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation.	Catechin	46-55	mitogen-activated protein kinase 3	Mus musculus	178-181
15340218-9	2004	These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation.	Catechin	46-55	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	220-232
15141082-0	2004	Oligomeric catechins: an enabling synthetic strategy by orthogonal activation and C(8) protection.	Catechin	11-20	homeobox C8	Homo sapiens	82-86
15297028-4	2004	Dual color flow cytometric analysis revealed that (+)-catechin reversed the reduction of the population of leukocytes (CD11b+ monocytes, Gr-1+ granulocytes and CD3+ T and CD45RA+ B lymphocytes) in whole blood, spleen and bone marrow caused by 5-FU.	Catechin	50-62	integrin subunit alpha M	Homo sapiens	119-124
15297028-5	2004	(+)-Catechin (1 and 10 mg/kg per day) showed remarkable recovery of Gr-1+ cells in all three types of tissues and of CD11b+ cells in the bone marrow cells.	Catechin	0-12	integrin subunit alpha M	Homo sapiens	117-122
15141082-2	2004	Bromo-capping of the C(8) position of the flavan skeleton enabled the equimolar coupling of electrophilic and nucleophilic catechin derivatives, enabling an efficient synthetic strategy to complex catechin oligomers.	Catechin	123-131	homeobox C8	Homo sapiens	21-25
15141082-2	2004	Bromo-capping of the C(8) position of the flavan skeleton enabled the equimolar coupling of electrophilic and nucleophilic catechin derivatives, enabling an efficient synthetic strategy to complex catechin oligomers.	Catechin	197-205	homeobox C8	Homo sapiens	21-25
15158152-0	2004	Green tea catechins inhibit neointimal hyperplasia in a rat carotid arterial injury model by TIMP-2 overexpression.	Catechin	10-19	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	93-99
15285844-0	2004	Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells.	Catechin	45-54	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
15285844-4	2004	Since these catechins inhibited the efflux of P-gp substrates, the elevation of substrate accumulation seemed to be induced by the inhibition of the efflux transporter.	Catechin	12-21	ATP binding cassette subfamily B member 1	Homo sapiens	46-50
15285844-6	2004	The presence of the galloyl moiety on the C-ring markedly increased the n-octanol/PBS partition coefficients of the catechins and their activity on P-gp.	Catechin	116-125	ATP binding cassette subfamily B member 1	Homo sapiens	148-152
15285844-7	2004	On the other hand, the presence of the trihydric pyrogallol group as the B-ring decreased the partition coefficients but increased the activity on P-gp, compared with the action of the corresponding catechins with a dihydric catechol B-ring.	Catechin	199-208	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
15133034-3	2004	EGCG and the related tea catechins potently inhibited both the FabG and FabI reductase steps in the fatty acid elongation cycle with IC(50) values between 5 and 15 microm.	Catechin	25-34	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	63-67
15207729-1	2004	Inhibition effects of (+)-catechin-aldehyde polycondensates against the activity of proteinases, Clostridium histolyticum collagenase (ChC) and human neutrophil elastase (HNE) causing proteolytic degradation of extracellular matrix (ECM), have been investigated.	Catechin	22-34	elastase, neutrophil expressed	Homo sapiens	150-169
15257617-4	2004	Both (-)-epicatechin and (-)-epicatechin gallate (ECG) supplementation resulted in an increased GSH/GSSG ratio and glutathione reductase activities.	Catechin	5-20	glutathione-disulfide reductase	Rattus norvegicus	115-136
15110290-6	2004	Following the optimisation of the paste composition, PPO-based carbon paste biosensors were prepared and presented excellent analytical properties toward catechol detection with a sensitivity of 4.7 A M(-1) cm(-2) and a response time lower than 20 s. The resulting biosensors were applied to the determination of polyphenolic compounds (e.g., epicatechin and ferulic acid).	Catechin	343-354	protoporphyrinogen oxidase	Homo sapiens	53-56
15264896-0	2004	Inhibitory Effects of the C-2 Epimeric Isomers of Tea Catechins on Mouse Type IV Allergy.	Catechin	54-63	complement component 2 (within H-2S)	Mus musculus	26-29
15264896-0	2004	Inhibitory Effects of the C-2 Epimeric Isomers of Tea Catechins on Mouse Type IV Allergy.	Catechin	54-63	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	50-53
15264896-4	2004	However, the antiallergic effects were weaker than those of their corresponding original tea catechins (2R,3R type).	Catechin	93-102	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	89-92
15264896-9	2004	The antiallergic effects of tea catechins and their C-2 epimers observed in this study were dose-dependent.	Catechin	32-41	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	28-31
15264896-9	2004	The antiallergic effects of tea catechins and their C-2 epimers observed in this study were dose-dependent.	Catechin	32-41	complement component 2 (within H-2S)	Mus musculus	52-55
15264896-10	2004	These results suggest that C-2 epimers of tea catechins, which are produced during heat processing at high temperatures, could be disadvantageous for the antiallergic effects on type IV allergy.	Catechin	46-55	complement component 2 (within H-2S)	Mus musculus	27-30
15264896-10	2004	These results suggest that C-2 epimers of tea catechins, which are produced during heat processing at high temperatures, could be disadvantageous for the antiallergic effects on type IV allergy.	Catechin	46-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	42-45
15158152-6	2004	Similarly, epigallocatechin-3-gallate, a major constituent of green tea catechins, significantly upregulated TIMP-2 expression in cultured smooth muscle cells.	Catechin	72-81	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	109-115
15158152-8	2004	CONCLUSION: These results indicate that catechins inhibit intimal hyperplasia in a rat balloon-injury model through the upregulation of TIMP-2 expression to modulate MMP activity.	Catechin	40-49	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	136-142
15491098-1	2004	AIM: To study the effect of catechin, the active component of Spatholobus suberectus Dunn, on bone marrow cell cycle and the expression of IL-6 and GM-CSF mRNA in spleen cells of normal and marrow-depressed mice in order to clarify the mechanism of hematopoietic-supportive effect of catechin.	Catechin	28-36	interleukin 6	Mus musculus	139-143
15208607-3	2004	For this purpose, we studied the effect of 2 kinds of catechin, epigallocatechin gallate (EGCG) and epicatechin gallate, on peripheral blood CD8+ T cells, which play the key role in immune responses.	Catechin	54-62	CD8a molecule	Homo sapiens	141-144
15208607-5	2004	Also, the effect of catechin on the ability of CD8+ T cells to bind intracellular adhesion molecule 1 and to migrate in response to chemokines was evaluated by using the adhesion and migration assays.	Catechin	20-28	CD8a molecule	Homo sapiens	47-50
15208607-6	2004	RESULTS: The 2 catechins directly bound to CD11b expressed on CD8+ T cells, which caused a consequent decrease of flow-cytometric CD11b expression.	Catechin	15-24	integrin subunit alpha M	Homo sapiens	43-48
15208607-6	2004	RESULTS: The 2 catechins directly bound to CD11b expressed on CD8+ T cells, which caused a consequent decrease of flow-cytometric CD11b expression.	Catechin	15-24	CD8a molecule	Homo sapiens	62-65
15208607-6	2004	RESULTS: The 2 catechins directly bound to CD11b expressed on CD8+ T cells, which caused a consequent decrease of flow-cytometric CD11b expression.	Catechin	15-24	integrin subunit alpha M	Homo sapiens	130-135
15208607-8	2004	CONCLUSION: We concluded that catechin, especially EGCG, by downregulating CD11b expression on CD8+ T cells and, in consequence, inhibiting infiltration of these cells into the sites of inflammation, is a promising new potent anti-inflammatory agent.	Catechin	30-38	integrin subunit alpha M	Homo sapiens	75-80
15208607-8	2004	CONCLUSION: We concluded that catechin, especially EGCG, by downregulating CD11b expression on CD8+ T cells and, in consequence, inhibiting infiltration of these cells into the sites of inflammation, is a promising new potent anti-inflammatory agent.	Catechin	30-38	CD8a molecule	Homo sapiens	95-98
15173662-10	2004	Dark staining for iNOS, neutrophils and peroxynitrite were observed in vessel wall of small arteries in control ischemic hemisphere, while in catechins (0.5%)-treated rats iNOS was detected slightly, and staining for neutrophils and peroxynitrite was not seen.	Catechin	142-151	nitric oxide synthase 2	Rattus norvegicus	172-176
15491098-2	2004	METHODS: Flow cytometry was adopted to investigate the influence of catechin on bone marrow cell cycle in mice and the expression of IL-6 and GM-CSF mRNA induced by catechin in spleen cells was detected by RT-PCR technique simultaneously.	Catechin	68-76	interleukin 6	Mus musculus	133-137
15491098-2	2004	METHODS: Flow cytometry was adopted to investigate the influence of catechin on bone marrow cell cycle in mice and the expression of IL-6 and GM-CSF mRNA induced by catechin in spleen cells was detected by RT-PCR technique simultaneously.	Catechin	165-173	interleukin 6	Mus musculus	133-137
15491098-2	2004	METHODS: Flow cytometry was adopted to investigate the influence of catechin on bone marrow cell cycle in mice and the expression of IL-6 and GM-CSF mRNA induced by catechin in spleen cells was detected by RT-PCR technique simultaneously.	Catechin	165-173	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	142-148
15491098-4	2004	Being induced by catechin, IL-6 mRNA and GM-CSF mRNA in spleen cells were markedly up-regulated.	Catechin	17-25	interleukin 6	Mus musculus	27-31
15491098-4	2004	Being induced by catechin, IL-6 mRNA and GM-CSF mRNA in spleen cells were markedly up-regulated.	Catechin	17-25	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	41-47
15100171-9	2004	Enzyme kinetic analyses showed that both tea catechins and bioflavonoids inhibited human liver COMT-mediated O-methylation of 4-OH-E(2) (a representative substrate) with a mixed mechanism of inhibition (competitive plus noncompetitive).	Catechin	45-54	catechol-O-methyltransferase	Homo sapiens	95-99
15100171-0	2004	Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.	Catechin	40-49	catechol-O-methyltransferase	Homo sapiens	146-174
15100171-10	2004	In summary, the catechol-containing tea catechins and bioflavonoids are strong inhibitors of human liver COMT-mediated O-methylation of catechol estrogens.	Catechin	40-49	catechol-O-methyltransferase	Homo sapiens	105-109
15150444-7	2004	Antioxidants such as glutathione (GSH), N-acetyl cysteine (NAC), curcumin, epigallocatechin gallate (EGCG) and epicatechin (EC) inhibited selenite-induced intracellular ROS elevation and JNK1 phosphorylation.	Catechin	111-122	mitogen-activated protein kinase 8	Homo sapiens	187-191
15033450-4	2004	EGCG and to a lesser extent ECG prevented the induction of VCAM-1 expression in a concentration-dependent manner after stimulation with TNF-alpha, whereas EC and EGC were without effect.	Catechin	28-30	vascular cell adhesion molecule 1	Homo sapiens	59-65
15033450-4	2004	EGCG and to a lesser extent ECG prevented the induction of VCAM-1 expression in a concentration-dependent manner after stimulation with TNF-alpha, whereas EC and EGC were without effect.	Catechin	28-30	tumor necrosis factor	Homo sapiens	136-145
15013844-9	2004	Myeloperoxidase activity of phorbol 12-myristate 13-acetate stimulated HL-60 cells was inhibited by (-)-epicatechin with an IC(50) value of 77.4 microM.	Catechin	100-115	myeloperoxidase	Homo sapiens	0-15
15087027-0	2004	[MDR-reversing effect of two components of catechin on human hepatocellular carcinoma BEL-7404/Adr in vitro].	Catechin	43-51	aldo-keto reductase family 1 member B	Homo sapiens	95-98
15087027-3	2004	The aim of this study was to investigate the MDR-reversing effect of two components of catechin on human hepatocellular carcinoma BEL-7404/Adr in vitro and its potential mechanism.	Catechin	87-95	aldo-keto reductase family 1 member B	Homo sapiens	139-142
15034065-4	2004	As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton"s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins.	Catechin	29-37	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	83-86
15034065-4	2004	As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton"s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins.	Catechin	29-37	spleen tyrosine kinase	Mus musculus	88-91
15034065-4	2004	As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton"s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins.	Catechin	29-37	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	97-121
15034065-4	2004	As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton"s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins.	Catechin	249-258	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	83-86
15034065-4	2004	As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton"s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins.	Catechin	249-258	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	97-121
15034065-6	2004	These catechins inhibit IgE/Ag-induced calcium response as well as the activation of downstream serine/threonine kinases such as Akt and c-Jun N-terminal kinase.	Catechin	6-15	thymoma viral proto-oncogene 1	Mus musculus	129-132
15114510-2	2004	The (-)-epicatechin and (+)-catechin derivatives comprised of aromatic groups increased activity and derivatives with acyl chain groups of carbon atoms in the close vicinity of C8 to C10 showed strong antimicrobial activity (MIC = 2 - 8 microg/ml) against Gram-positive bacteria and weak activity against fungi.	Catechin	4-19	CD99 molecule (Xg blood group)	Homo sapiens	225-232
15380733-10	2004	In addition, the inhibitory effect of UR against gelatinolytic activity of MMP-2 and -9 was higher than that of catechin and lower than that of epigallocatechin gallate.	Catechin	112-120	matrix metallopeptidase 2	Homo sapiens	75-87
15003008-3	2004	In the measurement of tyrosinase inhibition activity, (+)-catechin acted as substrate and cofactor of tyrosinase.	Catechin	54-66	tyrosinase	Homo sapiens	22-32
15003008-3	2004	In the measurement of tyrosinase inhibition activity, (+)-catechin acted as substrate and cofactor of tyrosinase.	Catechin	54-66	tyrosinase	Homo sapiens	102-112
15630184-2	2004	We previously found that the major green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has the suppressive effect of the FcepsilonRI expression in the human basophilic KU812 cells, whereas (-)-epicatechin-3-O-gallate (ECG) has not.	Catechin	45-53	Fc epsilon receptor Ia	Homo sapiens	130-141
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	Catechin	60-72	interleukin 1 beta	Mus musculus	134-142
14706851-0	2004	Lipid raft-associated catechin suppresses the FcepsilonRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2.	Catechin	22-30	Fc epsilon receptor Ia	Homo sapiens	46-57
14706851-0	2004	Lipid raft-associated catechin suppresses the FcepsilonRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2.	Catechin	22-30	mitogen-activated protein kinase 1	Homo sapiens	106-146
14706851-1	2004	The major green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has a suppressive effect on the expression of the high-affinity IgE receptor FcepsilonRI, which is key molecule in the IgE-mediated allergic reactions.	Catechin	20-28	Fc epsilon receptor Ia	Homo sapiens	148-159
15630269-1	2004	Long-term feeding of tea catechins suppressed body fat accumulation in high-fat diet-induced obesity in mice, and that their effects might be attributed, at least in part, to the activation of hepatic lipid metabolism.	Catechin	25-34	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
15630269-2	2004	Consecutive intake of tea catechins (588 mg/day) reduced body fat, especially abdominal fat in humans.	Catechin	26-35	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	22-25
15630269-3	2004	These results demonstrate that intake of tea catechins is beneficial for body fat accumulation.	Catechin	45-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Catechin	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	128-131
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Catechin	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Catechin	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Catechin	144-153	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Catechin	144-153	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15133320-9	2004	Furthermore, green tea catechin supplementation in diabetic rats also appeared to inhibit the production of leukotriene B4 based on regulating the activity of 5"-lipoxygenase, thereby potentially reducing renal oxidative damage and inflammatory reactions.	Catechin	23-31	arachidonate 5-lipoxygenase	Rattus norvegicus	159-174
15706060-0	2004	tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate.	Catechin	117-125	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	0-4
15630184-6	2004	On the other hand, the level of ECG in rafts was lower than that of EGCG, suggesting that the association with lipid rafts may have an important role in the FcepsilonRI-suppressive effect of catechins.	Catechin	191-200	Fc epsilon receptor Ia	Homo sapiens	157-168
14630700-0	2004	Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells.	Catechin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	68-77
14727916-2	2004	The planar catechin (P1H(2)), in which the catechol and chroman structure in (+)-catechin (1H(2)) are constrained to be planar, undergoes efficient hydrogen atom transfer toward galvinoxyol radical, showing an enhanced protective effect against the oxidative DNA damage induced by the Fenton reaction.	Catechin	11-19	minichromosome maintenance complex component 3	Homo sapiens	21-24
14727916-2	2004	The planar catechin (P1H(2)), in which the catechol and chroman structure in (+)-catechin (1H(2)) are constrained to be planar, undergoes efficient hydrogen atom transfer toward galvinoxyol radical, showing an enhanced protective effect against the oxidative DNA damage induced by the Fenton reaction.	Catechin	77-89	minichromosome maintenance complex component 3	Homo sapiens	21-24
14727916-4	2004	The kinetics of hydrogen transfer from catechins to cumylperoxyl radical has been examined in propionitrile at low temperature with use of ESR, showing that the rate of hydrogen transfer from P1H(2) is significantly faster than that from 1H(2).	Catechin	39-48	minichromosome maintenance complex component 3	Homo sapiens	192-195
14630705-2	2004	We have previously demonstrated that green tea catechins containing a galloyl group in the third position of the catechin structure interfere with PDGF-BB-induced mitogenic signaling pathways by inhibiting tyrosine phosphorylation of the PDGF-Rbeta.	Catechin	47-56	platelet derived growth factor receptor beta	Homo sapiens	238-248
14630705-2	2004	We have previously demonstrated that green tea catechins containing a galloyl group in the third position of the catechin structure interfere with PDGF-BB-induced mitogenic signaling pathways by inhibiting tyrosine phosphorylation of the PDGF-Rbeta.	Catechin	47-55	platelet derived growth factor receptor beta	Homo sapiens	238-248
14630700-0	2004	Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells.	Catechin	3-11	nuclear factor kappa B subunit 1	Homo sapiens	68-77
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	18-20	nuclear factor kappa B subunit 1	Homo sapiens	56-65
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	18-20	nuclear factor kappa B subunit 1	Homo sapiens	114-123
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	18-20	interleukin 2	Homo sapiens	136-140
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	22-24	nuclear factor kappa B subunit 1	Homo sapiens	56-65
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	22-24	nuclear factor kappa B subunit 1	Homo sapiens	114-123
14630700-6	2004	Pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB binding activity and the transactivation of the NF-kappaB-driven gene IL-2.	Catechin	22-24	interleukin 2	Homo sapiens	136-140
14630700-7	2004	EC, CT, and DP-B inhibited, in vitro, NF-kappaB binding to its DNA consensus sequence, but they had no effect on the binding activity of CREB or OCT-1.	Catechin	0-2	nuclear factor kappa B subunit 1	Homo sapiens	38-47
14630700-7	2004	EC, CT, and DP-B inhibited, in vitro, NF-kappaB binding to its DNA consensus sequence, but they had no effect on the binding activity of CREB or OCT-1.	Catechin	4-6	nuclear factor kappa B subunit 1	Homo sapiens	38-47
14974735-6	2003	OPN was comparable to polyphenols such as (+)-catechin, rutin and gallic acid in the antioxidative activity against linoleic acid peroxidation, and was an effective DPPH radical scavenger, though the DPPH radical-scavenging activity of OPN was somewhat lower than that of the polyphenols.	Catechin	42-54	secreted phosphoprotein 1	Homo sapiens	0-3
14675780-1	2003	It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin.	Catechin	176-187	angiotensin I converting enzyme	Homo sapiens	82-113
14675780-1	2003	It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin.	Catechin	176-187	angiotensin I converting enzyme	Homo sapiens	115-118
14664511-3	2003	After content analysis, it was found that CF-H is mainly composed of polyphenols including flavonoids (6.9%), procyanidins (2.2%), (+)-catechin (0.5%), and (-)-epicatechin (0.2%).	Catechin	131-143	complement component factor h	Mus musculus	42-46
14664511-3	2003	After content analysis, it was found that CF-H is mainly composed of polyphenols including flavonoids (6.9%), procyanidins (2.2%), (+)-catechin (0.5%), and (-)-epicatechin (0.2%).	Catechin	156-171	complement component factor h	Mus musculus	42-46
14592472-0	2003	Green tea catechins as a BACE1 (beta-secretase) inhibitor.	Catechin	10-19	beta-secretase 1	Homo sapiens	25-30
14592472-1	2003	In the course of searching for BACE1 (beta-secretase) inhibitors from natural products, the ethyl acetate soluble fraction of green tea, which was suspected to be rich in catechin content, showed potent inhibitory activity.	Catechin	171-179	beta-secretase 1	Homo sapiens	31-36
14592472-7	2003	The active catechins inhibited BACE1 activity in a non-competitive manner with a substrate in Dixon plots.	Catechin	11-20	beta-secretase 1	Homo sapiens	31-36
14599562-0	2003	The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase.	Catechin	32-41	fatty acid synthase	Homo sapiens	88-107
14599562-6	2003	Another gallated catechin, (-)-epicatechin gallate, was also found as a potent inhibitor of FAS and its inhibition characteristics are similar to (-)-epigallocatechin gallate.	Catechin	17-25	fatty acid synthase	Homo sapiens	92-95
14599562-9	2003	Here we identify the galloyl moiety of green tea catechins as critical in the inactivation of the ketoacyl reductase activity of FAS for the first time.	Catechin	49-58	fatty acid synthase	Homo sapiens	129-132
12940955-1	2003	The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA.	Catechin	255-263	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	165-169
14710821-6	2003	Following the optimization of the paste composition, PPO-based carbon paste biosensors were prepared and presented excellent analytical properties toward catechol detection with a sensitivity of 4.7 A M(-1) cm(-2) and a response time lower than 20 s. The resulting biosensors were finally applied to the determination of epicatechin and ferulic acid as flavonol and polyphenol model, respectively.	Catechin	321-332	protoporphyrinogen oxidase	Homo sapiens	53-56
12970085-0	2003	Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1.	Catechin	37-46	solute carrier family 2 member 1	Homo sapiens	162-167
14612555-13	2003	Reduction in risk was strongest among persons who had the low activity COMT alleles, suggesting these individuals were less efficient in eliminating tea catechins and may derive the most benefit from these compounds.	Catechin	153-162	catechol-O-methyltransferase	Homo sapiens	71-75
14608118-4	2003	In the present study, we found that pretreatment of the green tea extract enriched with catechin and epigallocatechin gallate (EGCG) by gavage inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Catechin	88-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	153-158
12918064-0	2003	Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule.	Catechin	10-19	vascular endothelial growth factor A	Homo sapiens	28-32
12918064-0	2003	Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule.	Catechin	10-19	cadherin 5	Homo sapiens	86-97
12918064-0	2003	Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule.	Catechin	10-19	AKT serine/threonine kinase 1	Homo sapiens	134-137
12918064-6	2003	Using tube formation of human microvascular endothelial cells (HMVEC) in culture as an in vitro model of angiogenesis, we reported that vascular endothelial growth factor (VEGF)-induced tube formation is inhibited by anti-VE-cadherin antibody and dose-dependently by green tea catechins.	Catechin	277-286	vascular endothelial growth factor A	Homo sapiens	136-170
12918064-6	2003	Using tube formation of human microvascular endothelial cells (HMVEC) in culture as an in vitro model of angiogenesis, we reported that vascular endothelial growth factor (VEGF)-induced tube formation is inhibited by anti-VE-cadherin antibody and dose-dependently by green tea catechins.	Catechin	277-286	vascular endothelial growth factor A	Homo sapiens	172-176
12918064-6	2003	Using tube formation of human microvascular endothelial cells (HMVEC) in culture as an in vitro model of angiogenesis, we reported that vascular endothelial growth factor (VEGF)-induced tube formation is inhibited by anti-VE-cadherin antibody and dose-dependently by green tea catechins.	Catechin	277-286	cadherin 5	Homo sapiens	222-233
12918064-8	2003	These findings indicate that VE-cadherin and Akt, known downstream proteins in VEGFR-2-mediated cascade, are the new-targeted proteins by which green tea catechins inhibit angiogenesis.	Catechin	154-163	cadherin 5	Homo sapiens	29-40
12918064-8	2003	These findings indicate that VE-cadherin and Akt, known downstream proteins in VEGFR-2-mediated cascade, are the new-targeted proteins by which green tea catechins inhibit angiogenesis.	Catechin	154-163	AKT serine/threonine kinase 1	Homo sapiens	45-48
12918064-8	2003	These findings indicate that VE-cadherin and Akt, known downstream proteins in VEGFR-2-mediated cascade, are the new-targeted proteins by which green tea catechins inhibit angiogenesis.	Catechin	154-163	kinase insert domain receptor	Homo sapiens	79-86
12865088-8	2003	In the catechin supplemented group serum osteocalcin content values were lower than the control group.	Catechin	7-15	bone gamma-carboxyglutamate protein	Rattus norvegicus	41-52
12659723-5	2003	In the liver, (+)-catechin or (-)-epicatechin decreased the total amount of CYP450 in both GF and HFA rats while the isoenzyme CYP2E1 decreased.	Catechin	14-26	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Catechin	43-51	coagulation factor II, thrombin	Homo sapiens	73-81
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Catechin	43-51	coagulation factor II, thrombin	Homo sapiens	161-169
12870889-2	2003	In an effort to understand the compound(s) responsible for this protection, the effects of green tea extracts (GTE) and individual green tea catechins on aryl hydrocarbon receptor (AhR) gene induction were determined.	Catechin	141-150	aryl-hydrocarbon receptor	Mus musculus	154-179
12705967-3	2003	Conjugated-form catechins in plasma were hydrolyzed enzymatically using beta-glucuronidase and sulfatase.	Catechin	16-25	arylsulfatase family member H	Homo sapiens	95-104
12801907-0	2003	Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin).	Catechin	32-41	matrix metallopeptidase 7	Homo sapiens	67-93
12801907-0	2003	Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin).	Catechin	32-41	matrix metallopeptidase 7	Homo sapiens	95-105
12801907-4	2003	The inhibitory effects of green tea catechins suggest that a high intake of green tea might be effective for the prevention of tumor metastasis and invasion in which matrilysin is concerned.	Catechin	36-45	matrix metallopeptidase 7	Homo sapiens	166-176
12606047-2	2003	The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO(2) radical.	Catechin	86-101	myeloperoxidase	Homo sapiens	178-181
12623326-1	2003	We investigated the effects of inhalation of tea catechin on MRSA in the 24 elderly in patients, who were known to carry MRSA in sputum.	Catechin	49-57	solute carrier family 9 member A6	Homo sapiens	61-65
12623326-4	2003	After a week of the course, the numbers of the patients with decreased or disappearance of MRSA in their sputum was significantly higher in the catechin group, compared with that in the control group (seven vs. no patients; P&lt;0.05).	Catechin	144-152	solute carrier family 9 member A6	Homo sapiens	91-95
12623326-8	2003	Catechin inhalation seemed to be safe, and at least temporarily effective in the reduction of MRSA and shortening of hospitalization.	Catechin	0-8	solute carrier family 9 member A6	Homo sapiens	94-98
12753411-0	2003	Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX).	Catechin	4-12	tripartite motif containing 33	Homo sapiens	113-117
12682270-3	2003	We have previously shown that the most abundant catechin of green tea, (-)epigallocatechin-3-gallate (EGCG), strongly inhibits neutrophil elastase.	Catechin	48-56	elastase, neutrophil expressed	Homo sapiens	127-146
12673036-3	2003	(+)-Catechin caused a significant elevation of cell survival at 10(-5) and 10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) production and apoptosis in osteoblasts.	Catechin	0-12	tumor necrosis factor	Mus musculus	212-221
12673036-3	2003	(+)-Catechin caused a significant elevation of cell survival at 10(-5) and 10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) production and apoptosis in osteoblasts.	Catechin	0-12	interleukin 6	Mus musculus	226-230
12673036-3	2003	(+)-Catechin caused a significant elevation of cell survival at 10(-5) and 10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) production and apoptosis in osteoblasts.	Catechin	152-164	tumor necrosis factor	Mus musculus	212-221
12673036-3	2003	(+)-Catechin caused a significant elevation of cell survival at 10(-5) and 10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) production and apoptosis in osteoblasts.	Catechin	152-164	interleukin 6	Mus musculus	226-230
12429981-4	2002	Analysis of the expression of cell cycle-related proteins after the addition of catechin showed that the cyclin-dependent kinase (cdk) 2 and the cdk4 proteins were decreased after administration, the expression of cyclin A protein was increased at 24 h after administration, however, the expression of the cyclin D1 and cyclin E proteins was unchanged.	Catechin	80-88	cyclin dependent kinase 2	Homo sapiens	105-136
12482547-5	2003	In the present study, we investigated the effect of catechins on the gelatinolytic activity of MMP-2 that was derived from cultured bovine aortic SMCs.	Catechin	52-61	matrix metallopeptidase 2	Bos taurus	95-100
12482547-7	2003	A major constituent of green tea catechins, (-)-epigallocatechin gallate (EGCG), inhibited the gelatinolytic activity of MMP-2 and concanavalin A (ConA)-induced pro-MMP-2 activation without the influence of membrane-type MMP expression in SMCs.	Catechin	33-42	matrix metallopeptidase 2	Bos taurus	121-126
12482547-7	2003	A major constituent of green tea catechins, (-)-epigallocatechin gallate (EGCG), inhibited the gelatinolytic activity of MMP-2 and concanavalin A (ConA)-induced pro-MMP-2 activation without the influence of membrane-type MMP expression in SMCs.	Catechin	33-42	matrix metallopeptidase 2	Bos taurus	165-170
12482547-7	2003	A major constituent of green tea catechins, (-)-epigallocatechin gallate (EGCG), inhibited the gelatinolytic activity of MMP-2 and concanavalin A (ConA)-induced pro-MMP-2 activation without the influence of membrane-type MMP expression in SMCs.	Catechin	33-42	matrix metallopeptidase 2	Bos taurus	121-124
14604298-8	2003	They can inhibit VEGF formation (as used in cerebral oedema dexamethason, or barbiturates, trichstatin A, candesartan, small molecule inhibitors of hypoxia-inducible factor 1, gelandamycin, antysenses, rybosymes and catechins) or VEGF activity (soluble receptors, monoclonal antibodies, heterodimeric antagonistic VEGF variant, RTK inhibitors and catechins).	Catechin	216-225	vascular endothelial growth factor A	Homo sapiens	17-21
14604298-8	2003	They can inhibit VEGF formation (as used in cerebral oedema dexamethason, or barbiturates, trichstatin A, candesartan, small molecule inhibitors of hypoxia-inducible factor 1, gelandamycin, antysenses, rybosymes and catechins) or VEGF activity (soluble receptors, monoclonal antibodies, heterodimeric antagonistic VEGF variant, RTK inhibitors and catechins).	Catechin	347-356	vascular endothelial growth factor A	Homo sapiens	17-21
14769544-1	2003	According to several studies, green tea and individual catechins can inhibit the induction of ornithine decarboxylase (ODC), the key enzyme in the biosynthesis of polyamines.	Catechin	55-64	ornithine decarboxylase 1	Homo sapiens	94-117
14769544-1	2003	According to several studies, green tea and individual catechins can inhibit the induction of ornithine decarboxylase (ODC), the key enzyme in the biosynthesis of polyamines.	Catechin	55-64	ornithine decarboxylase 1	Homo sapiens	119-122
12397093-6	2002	Importantly, the concentrations of red wine/catechins shown to inhibit the PDGFR in vitro correlate with the serum levels after red wine consumption in humans.	Catechin	44-53	platelet derived growth factor receptor beta	Homo sapiens	75-80
12429981-8	2002	Based on these results, we speculate that, in the breast cancer cell line T47D, catechin phosphorylated JNK/SAPK and p38, and that the phosphorylated JNK/SAPK and p38 inhibited the phosphorylation of cdc2, and regulated the expression of cyclin A, cyclin B1, and cdk proteins, thereby causing G2 arrest.	Catechin	80-88	cyclin A2	Homo sapiens	238-246
12429981-4	2002	Analysis of the expression of cell cycle-related proteins after the addition of catechin showed that the cyclin-dependent kinase (cdk) 2 and the cdk4 proteins were decreased after administration, the expression of cyclin A protein was increased at 24 h after administration, however, the expression of the cyclin D1 and cyclin E proteins was unchanged.	Catechin	80-88	cyclin dependent kinase 4	Homo sapiens	145-149
12429981-4	2002	Analysis of the expression of cell cycle-related proteins after the addition of catechin showed that the cyclin-dependent kinase (cdk) 2 and the cdk4 proteins were decreased after administration, the expression of cyclin A protein was increased at 24 h after administration, however, the expression of the cyclin D1 and cyclin E proteins was unchanged.	Catechin	80-88	cyclin A2	Homo sapiens	214-222
12429981-5	2002	At 24 h after the administration of catechin, the phosphorylation of cell division cycle 2 (cdc2) was inhibited, and the expression of cyclin B1 protein was also decreased.	Catechin	36-44	cyclin dependent kinase 1	Homo sapiens	69-90
12429981-5	2002	At 24 h after the administration of catechin, the phosphorylation of cell division cycle 2 (cdc2) was inhibited, and the expression of cyclin B1 protein was also decreased.	Catechin	36-44	cyclin dependent kinase 1	Homo sapiens	92-96
12429981-5	2002	At 24 h after the administration of catechin, the phosphorylation of cell division cycle 2 (cdc2) was inhibited, and the expression of cyclin B1 protein was also decreased.	Catechin	36-44	cyclin B1	Homo sapiens	135-144
12429981-7	2002	The phosphorylation of p38 protein was increased at 12 h, and began to decrease at 36 h after catechin administration.	Catechin	94-102	mitogen-activated protein kinase 14	Homo sapiens	23-26
12429981-8	2002	Based on these results, we speculate that, in the breast cancer cell line T47D, catechin phosphorylated JNK/SAPK and p38, and that the phosphorylated JNK/SAPK and p38 inhibited the phosphorylation of cdc2, and regulated the expression of cyclin A, cyclin B1, and cdk proteins, thereby causing G2 arrest.	Catechin	80-88	mitogen-activated protein kinase 14	Homo sapiens	117-120
12429981-8	2002	Based on these results, we speculate that, in the breast cancer cell line T47D, catechin phosphorylated JNK/SAPK and p38, and that the phosphorylated JNK/SAPK and p38 inhibited the phosphorylation of cdc2, and regulated the expression of cyclin A, cyclin B1, and cdk proteins, thereby causing G2 arrest.	Catechin	80-88	cyclin dependent kinase 1	Homo sapiens	200-204
12429981-8	2002	Based on these results, we speculate that, in the breast cancer cell line T47D, catechin phosphorylated JNK/SAPK and p38, and that the phosphorylated JNK/SAPK and p38 inhibited the phosphorylation of cdc2, and regulated the expression of cyclin A, cyclin B1, and cdk proteins, thereby causing G2 arrest.	Catechin	80-88	cyclin B1	Homo sapiens	248-257
12377984-0	2002	Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro.	Catechin	51-60	estrogen receptor 1	Homo sapiens	0-17
12147326-5	2002	In the cultured rat brain astrocytes (RBA), the activity of SOD (both Cu, Zn-SOD and Mn-SOD subtypes) was markedly increased by incubation with catechin at low concentration (0.1 microM) for 2 days (short-term) and 7 days (long-term).	Catechin	144-152	superoxide dismutase 2	Rattus norvegicus	85-91
12236706-0	2002	Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells.	Catechin	17-25	Fc epsilon receptor Ia	Homo sapiens	85-96
12237135-0	2002	Elevation of P-glycoprotein function by a catechin in green tea.	Catechin	42-50	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
12237135-4	2002	We characterized several green tea catechins for their interaction with P-gp and their specific effects on P-gp export activity of several marker substrates.	Catechin	35-44	ATP binding cassette subfamily B member 1	Homo sapiens	72-76
12237135-4	2002	We characterized several green tea catechins for their interaction with P-gp and their specific effects on P-gp export activity of several marker substrates.	Catechin	35-44	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
12237135-6	2002	Remarkably, others of these catechins facilitate the P-gp-mediated transport of LDS without affecting daunorubicin (DNR) transport or Rho.	Catechin	28-37	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
12237135-7	2002	Moreover, (-)epicatechin, though an inhibitor of Rho transport, can significantly enhance the active net transport of another P-gp marker substrate, LDS.	Catechin	10-24	ATP binding cassette subfamily B member 1	Homo sapiens	126-130
12237135-8	2002	This result indicates that (-)epicatechin may bind to and activate an allosteric site that enhances P-gp overall function or efficiency.	Catechin	30-41	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
12124307-3	2002	In the present study, we determined the metabolism of EC, focusing on its glucuronic acid and sulfate conjugation using human liver and intestinal microsomes and cytosol as well as recombinant UDP-glucuronosyltransferase (UGT) and sulfotransferase (SULT) isoforms in comparison with that occurring in the rat.	Catechin	54-56	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	222-225
12188378-2	2002	We report the use of the enzyme tyrosinase to graft the natural phenol, catechin, onto the biopolymer chitosan.	Catechin	72-80	tyrosinase	Homo sapiens	32-42
12097654-7	2002	We conclude that (-)-epicatechin and its low-molecular procyanidins inhibit both dioxygenase and LTA(4) synthase activities of human 5-lipoxygenase and that this action may contribute to a putative anti-inflammatory effect of cocoa products.	Catechin	17-32	arachidonate 5-lipoxygenase	Homo sapiens	133-147
12097653-7	2002	(-)-Epicatechin, 3beta, 22beta-dihydroxyolean-12-en-29-oic acid and the tannin fraction inhibited LPL activity with IC(50) of 81 (54-214), 89 (62-214) and 35 (24-62) mg/L.	Catechin	0-15	lipoprotein lipase	Rattus norvegicus	98-101
12135191-3	2002	This study evaluated the effect of catechin on the MnSOD activity and mRNA level of pheochromocytoma cells (PC-12).	Catechin	35-43	superoxide dismutase 2	Rattus norvegicus	51-56
12175544-0	2002	Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding.	Catechin	4-13	vascular endothelial growth factor A	Homo sapiens	140-144
12175544-5	2002	When these four catechins were tested on VEGF binding assay, only EGCg inhibited the binding of VEGF, a major angiogenesis inducing factor, to endothelial cells in a concentration dependent manner.	Catechin	16-25	vascular endothelial growth factor A	Homo sapiens	96-100
12110373-10	2002	It is concluded that TPA affects Cx43 trafficking between cellular compartments, and that this effect is counteracted by (-)-epicatechin or genistein.	Catechin	121-136	gap junction protein, alpha 1	Rattus norvegicus	33-37
12033808-8	2002	Procyanidin B3, catechin, and epicatechin were noninhibitory against nNOS activity.	Catechin	16-24	nitric oxide synthase 1	Homo sapiens	69-73
12033808-8	2002	Procyanidin B3, catechin, and epicatechin were noninhibitory against nNOS activity.	Catechin	30-41	nitric oxide synthase 1	Homo sapiens	69-73
11958645-0	2002	Human apo A-I and rat transferrin are the principal plasma proteins that bind wine catechins.	Catechin	83-92	apolipoprotein A1	Rattus norvegicus	6-13
11958645-0	2002	Human apo A-I and rat transferrin are the principal plasma proteins that bind wine catechins.	Catechin	83-92	transferrin	Rattus norvegicus	22-33
12135191-6	2002	RESULTS: After incubation for 2 days, catechin slightly but significantly increased the activity of copper/zinc superoxide dismutase (CuZnSOD).	Catechin	38-46	superoxide dismutase 1	Rattus norvegicus	134-141
12135191-11	2002	The present data suggest that catechin can increase MnSOD gene expression in PC-12, which might have beneficial effect in tumor prevention.	Catechin	30-38	superoxide dismutase 2	Rattus norvegicus	52-57
11871760-9	2002	Catechin also significantly inhibited the release of gastrin, somatostatin, and histamine.	Catechin	0-8	gastrin	Rattus norvegicus	53-60
12230237-0	2002	Green tea catechin improves microsomal phospholipase A2 activity and the arachidonic acid cascade system in the kidney of diabetic rats.	Catechin	10-18	phospholipase A2 group IB	Rattus norvegicus	39-55
12230237-1	2002	The purpose of this study was to investigate the effects of green tea catechin on the microsomal phospholipase A2 activity and arachidonic acid cascade in the kidneys of streptozotocin-induced diabetic rats.	Catechin	70-78	phospholipase A2 group IB	Rattus norvegicus	97-113
11853888-2	2002	In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells.	Catechin	95-104	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
11853888-2	2002	In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells.	Catechin	95-104	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
11853888-5	2002	Among the catechins present in GTPs, EGCG, ECG and CG are responsible for inhibiting P-gp.	Catechin	10-19	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
11809684-2	2002	In this work, we report that green tea catechins are novel inhibitors of VEGFR-2 activity.	Catechin	39-48	kinase insert domain receptor	Homo sapiens	73-80
11809684-5	2002	The inhibition of VEGFR-2 activity by the catechins displayed positive correlation with the suppression of in vitro angiogenesis.	Catechin	42-51	kinase insert domain receptor	Homo sapiens	18-25
11755158-5	2002	ERK1/2 activity was only partly inhibited by green tea catechins alone or in combination with N-acetylcysteine (P&lt;0.05).	Catechin	55-64	mitogen-activated protein kinase 3	Homo sapiens	0-6
12495261-16	2002	In conclusion, it would appear that green tea catechin supplementation in chronic cadmium-poisoned rats inhibits the arachidonic acid cascade by regulating the activity of phospholipase A2.	Catechin	46-54	phospholipase A2 group IB	Rattus norvegicus	172-188
11871760-9	2002	Catechin also significantly inhibited the release of gastrin, somatostatin, and histamine.	Catechin	0-8	somatostatin	Rattus norvegicus	62-74
11936850-2	2002	This study showed that HepG2 cells pretreated with EC and EGCG for 8 h exerted a dose-dependent inhibitory effect on apoB secretion.	Catechin	51-53	apolipoprotein B	Homo sapiens	117-121
11936850-4	2002	Under lipid-rich conditions, apoB secretion was markedly reduced by EGCG and to a lesser extent by EC at 50 microM.	Catechin	99-101	apolipoprotein B	Homo sapiens	29-33
11936850-0	2002	Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells.	Catechin	10-19	apolipoprotein B	Homo sapiens	29-49
11936850-5	2002	Mechanistic study showed that tea catechins inhibited apoB secretion via a proteasome-independent pathway as indicated by a lack of response to N-acetyl-leucyl-leucyl-norleucinal (ALLN), a proteasome inhibitor.	Catechin	34-43	apolipoprotein B	Homo sapiens	54-58
11936850-8	2002	The results indicate that the gallate moiety in the catechin molecule may result in a beneficial effect on lipid metabolism in terms of apoB secretion.	Catechin	52-60	apolipoprotein B	Homo sapiens	136-140
11826958-4	2001	Furthermore, the order of the partition coefficients of catechins in an n-octanol/PBS system is the same as that of the amount incorporated into liposomes.	Catechin	56-65	cholinergic receptor muscarinic 3	Homo sapiens	82-85
12688521-7	2002	This IL-8 production was inhibited by catechins.	Catechin	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
12688521-10	2002	Of these major effects, the strongest effect of catechins was to reduce expression of the adhesion molecules CD1lb and CD18 on PMNs.	Catechin	48-57	CD1b molecule	Homo sapiens	109-112
12688521-10	2002	Of these major effects, the strongest effect of catechins was to reduce expression of the adhesion molecules CD1lb and CD18 on PMNs.	Catechin	48-57	integrin subunit beta 2	Homo sapiens	119-123
11843182-4	2001	(-)-Epicatechin and procyanidin nonamer also inhibited the formation of 15-hydroxy-eicosatetraenoic acid from arachidonic acid in rabbit smooth muscle cells transfected with human 15-lipoxygenase-1.	Catechin	0-15	arachidonate 15-lipoxygenase	Homo sapiens	180-195
11780762-0	2001	Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase.	Catechin	24-33	catechol-O-methyltransferase	Rattus norvegicus	84-112
11558573-9	2001	These results indicate that catechins are capable of inhibiting P-ST activity in intact cells as well as in vitro.	Catechin	28-37	sulfotransferase family 1A member 1	Homo sapiens	64-68
11759010-3	2001	The former, which showed strong anti-GTF activity, were polymeric epicatechins with C-4beta and C-8 intermolecular bonds estimated to be 4636 in molecular weight in an acetylated form.	Catechin	66-78	complement C4B (Chido blood group)	Rattus norvegicus	84-91
11535118-5	2001	OxLDL stimulated a Ca(2+)-dependent activation of both ERK1/2 and JNK that was strongly inhibited by pre-treatment with low micromolar concentrations of epicatechin.	Catechin	153-164	mitogen-activated protein kinase 3	Homo sapiens	55-61
11535118-5	2001	OxLDL stimulated a Ca(2+)-dependent activation of both ERK1/2 and JNK that was strongly inhibited by pre-treatment with low micromolar concentrations of epicatechin.	Catechin	153-164	mitogen-activated protein kinase 8	Homo sapiens	66-69
11535118-8	2001	Furthermore, oxLDL induced the cleavage of procaspase-3 and increased caspase-3-like protease activity in neurons, an effect which was strongly inhibited by pre-exposure to either epicatechin or kaempferol.	Catechin	180-191	caspase 3	Homo sapiens	43-55
11535118-8	2001	Furthermore, oxLDL induced the cleavage of procaspase-3 and increased caspase-3-like protease activity in neurons, an effect which was strongly inhibited by pre-exposure to either epicatechin or kaempferol.	Catechin	180-191	caspase 3	Homo sapiens	46-55
11714300-4	2001	Linoleate peroxidation by cytochrome c was inhibited by betanin, betanidin, catechin, and alpha-tocopherol with IC(50) values of 0.4, 0.8, 1.2, and 5 microM, respectively.	Catechin	76-84	cytochrome c, somatic	Homo sapiens	26-38
11714371-4	2001	An ethyl acetate extract of green tea, containing 70% (w/w) catechins, also increased the LDL receptor binding activity, protein, and mRNA, indicating that (1) the effect was at the level of gene transcription and that (2) the catechins were the active constituents.	Catechin	60-69	low density lipoprotein receptor	Homo sapiens	90-102
11714371-4	2001	An ethyl acetate extract of green tea, containing 70% (w/w) catechins, also increased the LDL receptor binding activity, protein, and mRNA, indicating that (1) the effect was at the level of gene transcription and that (2) the catechins were the active constituents.	Catechin	227-236	low density lipoprotein receptor	Homo sapiens	90-102
11697467-8	2001	There was a 50% reduction in the efflux of EC in the presence of 50 microM MK-571, a competitive inhibitor of the MRP2 transporter expressed in the apical membrane of Caco-2 cells.	Catechin	43-45	ATP binding cassette subfamily C member 2	Homo sapiens	114-118
11697467-14	2001	CONCLUSIONS: These results suggest an important role for the multispecific organic anion transporter MRP2 in the bioavailability of EC and possibly other tea flavonoids.	Catechin	132-134	ATP binding cassette subfamily C member 2	Homo sapiens	101-105
11558573-10	2001	We believe that the inhibitory activity of catechins might be the mechanism by which catechins (and green tea) exert anti-carcinogenic activity against procarcinogenic compounds that require P-ST activation in vivo.	Catechin	43-52	sulfotransferase family 1A member 1	Homo sapiens	191-195
11558573-10	2001	We believe that the inhibitory activity of catechins might be the mechanism by which catechins (and green tea) exert anti-carcinogenic activity against procarcinogenic compounds that require P-ST activation in vivo.	Catechin	85-94	sulfotransferase family 1A member 1	Homo sapiens	191-195
11553037-0	2001	Insulin-like effect of (-)epicatechin on erythrocyte membrane acetylcholinesterase activity in type 2 diabetes mellitus.	Catechin	23-37	insulin	Homo sapiens	0-7
11553037-0	2001	Insulin-like effect of (-)epicatechin on erythrocyte membrane acetylcholinesterase activity in type 2 diabetes mellitus.	Catechin	23-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-82
11553037-5	2001	Epicatechin, a member of a group of polyphenolic compounds collectively known as "catechins" that are present in tea and belong to the flavonoid family, has been reported to possess insulin-like activity.	Catechin	0-11	insulin	Homo sapiens	182-189
11553037-5	2001	Epicatechin, a member of a group of polyphenolic compounds collectively known as "catechins" that are present in tea and belong to the flavonoid family, has been reported to possess insulin-like activity.	Catechin	82-91	insulin	Homo sapiens	182-189
11553037-7	2001	In the present study, the in vitro effect of (-)epicatechin and/or insulin was tested on erythrocyte membrane AChE in normal and type 2 diabetic patients.	Catechin	45-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-114
11553037-8	2001	The aim of the study was to test the efficacy of (-)epicatechin to mimic insulin in its effect on erythrocyte membrane AChE.	Catechin	49-63	insulin	Homo sapiens	73-80
11553037-8	2001	The aim of the study was to test the efficacy of (-)epicatechin to mimic insulin in its effect on erythrocyte membrane AChE.	Catechin	49-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
11553037-11	2001	Epicatechin (1 mmol/L) also caused an elevation in AChE activity in diabetic erythrocytes, an effect that was similar to the effect of insulin.	Catechin	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
11553037-13	2001	Epicatechin has a pronounced insulin-like effect on erythrocyte membrane-bound AChE in type 2 diabetic patients; however, the mechanism of action of epicatechin remains speculative.	Catechin	0-11	insulin	Homo sapiens	29-36
11553037-13	2001	Epicatechin has a pronounced insulin-like effect on erythrocyte membrane-bound AChE in type 2 diabetic patients; however, the mechanism of action of epicatechin remains speculative.	Catechin	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
11470492-6	2001	The IC(50) values of catechins for the inhibition of human CYP were roughly the same as those seen in the mutagenic activation.	Catechin	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-62
11470492-0	2001	Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.	Catechin	24-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-100
11596865-1	2001	Catechins, polyphenolic compounds belonging to flavanoid family, have been reported to posses insulin-like properties and their antidiabetic actions have also been documented.	Catechin	0-9	insulin	Homo sapiens	94-101
11453660-4	2001	However, at epicatechin concentrations completely preventing nitration of tyrosine by peroxynitrite, protection against the oxidative inactivation of glyceraldehyde-3-phosphate dehydrogenase or soybean lipoxygenase-1 was marginal (IC(50) &gt; 1 mol epicatechin/mol peroxynitrite), approximately two orders of magnitude less.	Catechin	12-23	seed linoleate 13S-lipoxygenase-1	Glycine max	202-216
11470492-5	2001	Catechins also inhibited the oxidations of typical substrates catalyzed by human CYPs, namely ethoxycoumarin O-deethylation by CYP1A1, ethoxyresorufin O-deethylation by CYP1A2 and midazolam 1"-hydroxylation by CYP3A4.	Catechin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-133
11470492-5	2001	Catechins also inhibited the oxidations of typical substrates catalyzed by human CYPs, namely ethoxycoumarin O-deethylation by CYP1A1, ethoxyresorufin O-deethylation by CYP1A2 and midazolam 1"-hydroxylation by CYP3A4.	Catechin	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	169-175
11470492-5	2001	Catechins also inhibited the oxidations of typical substrates catalyzed by human CYPs, namely ethoxycoumarin O-deethylation by CYP1A1, ethoxyresorufin O-deethylation by CYP1A2 and midazolam 1"-hydroxylation by CYP3A4.	Catechin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	210-216
11522280-5	2001	p53 content of MCF-7 breast cancer cells (wild-type) was increased by caffeic acid, decreased by resveratrol, and showed a twofold increase with catechin, that reached borderline statistical significance; however, none of these effects were dose-responsive.	Catechin	145-153	tumor protein p53	Homo sapiens	0-3
11453730-0	2001	Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450.	Catechin	0-8	tyrosinase	Rattus norvegicus	66-76
11453730-2	2001	In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-glutathione conjugates of catechin and mono- and bi-glutathione conjugates of a catechin dimer.	Catechin	128-136	tyrosinase	Rattus norvegicus	170-180
11453730-2	2001	In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-glutathione conjugates of catechin and mono- and bi-glutathione conjugates of a catechin dimer.	Catechin	272-280	tyrosinase	Rattus norvegicus	170-180
11453730-2	2001	In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-glutathione conjugates of catechin and mono- and bi-glutathione conjugates of a catechin dimer.	Catechin	272-280	tyrosinase	Rattus norvegicus	170-180
11453730-4	2001	Using UV spectroscopy, it was shown that the catechol B-ring of catechin was oxidized by tyrosinase to form an o-quinone which could be reduced back to catechin with potassium borohydride or reacted with GSH to form glutathione conjugates.	Catechin	64-72	tyrosinase	Rattus norvegicus	89-99
11453730-4	2001	Using UV spectroscopy, it was shown that the catechol B-ring of catechin was oxidized by tyrosinase to form an o-quinone which could be reduced back to catechin with potassium borohydride or reacted with GSH to form glutathione conjugates.	Catechin	152-160	tyrosinase	Rattus norvegicus	89-99
11333849-8	2001	RESULTS: Pretreatment of HAEC with (+)-catechin metabolites inhibited U937 cell adhesion to IL-1 beta-stimulated cells, whereas pretreatment with intact (+)-catechin had no effect.	Catechin	35-47	interleukin 1 beta	Homo sapiens	92-101
11453773-7	2001	On the basis of a still significant French wine consumption of 180 mL/day/person, the current daily intake of catechins (monomers and dimers B1, B2, B3, and B4) averaged 5 (dry white wine), 4.36 (sweet white wines), 7.70 (rose wines), 31.98 (red wines), and 66.94 (dry white wine enriched in phenolic) mg/day/resident for the French population.	Catechin	110-119	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	141-159
11333849-9	2001	Generation of ROS in hydrogen peroxide-stimulated HAEC was inhibited by (+)-catechin, its metabolites, and control plasma extract, whereas ROS generation in IL-1 beta-stimulated HAEC was inhibited by (+)-catechin metabolites only.	Catechin	200-212	interleukin 1 beta	Homo sapiens	157-166
11367578-2	2001	The photon intensity was affected by the ferric state of Hb (methemoglobin &gt; oxyhemoglobin), and was roughly correlated with the radical-scavenging potential of catechins.	Catechin	164-173	hemoglobin subunit gamma 2	Homo sapiens	61-74
11316894-11	2001	CONCLUSION: UVC radiation in the presence of catechins, especially epigallocatechin gallate, appears to be an effective method of increasing the viral safety of FVIII concentrates without the loss of coagulation activity.	Catechin	45-54	coagulation factor VIII	Homo sapiens	161-166
11368631-0	2001	A tea catechin suppresses the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.	Catechin	6-14	Fc epsilon receptor Ia	Homo sapiens	75-88
11383321-9	2001	CONCLUSIONS: Our data indicate that DRW and its catechin-anthocyanidin fraction exert a significant effect on platelet aggregation in vitro, perhaps by enhancing platelet c-AMP levels.	Catechin	48-56	cathelicidin antimicrobial peptide	Rattus norvegicus	171-176
11236827-3	2001	These studies were carried out to determine whether individual phenolics (i.e., catechin, epicatechin, quercetin, and resveratrol) affect fibrinolytic protein (tissue-type plasminogen activator [t-PA] and urokinase-type PA [u-PA]) expression and surface-localized fibrinolytic activity in cultured human umbilical vein endothelial cells (HUVECs).	Catechin	80-88	plasminogen activator, tissue type	Homo sapiens	160-193
11259102-3	2001	In the in vitro studies, (-)-epigallocatechin gallate (EGCG), the most abundant catechin in green tea extract, inhibited Erk-1 and Erk-2 activation in a dose-dependent manner.	Catechin	37-45	mitogen-activated protein kinase 3	Homo sapiens	121-126
11259102-3	2001	In the in vitro studies, (-)-epigallocatechin gallate (EGCG), the most abundant catechin in green tea extract, inhibited Erk-1 and Erk-2 activation in a dose-dependent manner.	Catechin	37-45	mitogen-activated protein kinase 1	Homo sapiens	131-136
11237853-0	2001	Epicatechin and its in vivo metabolite, 3"-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation.	Catechin	0-11	caspase 3	Homo sapiens	142-151
11196148-0	2001	(+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse.	Catechin	0-12	PTK2 protein tyrosine kinase 2	Mus musculus	64-85
11196148-7	2001	Mechanistic studies linked this effect to (+)-catechin-induced changes in integrin-mediated intestinal cell-survival signaling, including structural alteration of the actin cytoskeleton and decreased focal adhesion kinase (FAK) tyrosine phosphorylation.	Catechin	42-54	PTK2 protein tyrosine kinase 2	Mus musculus	200-221
11196148-7	2001	Mechanistic studies linked this effect to (+)-catechin-induced changes in integrin-mediated intestinal cell-survival signaling, including structural alteration of the actin cytoskeleton and decreased focal adhesion kinase (FAK) tyrosine phosphorylation.	Catechin	42-54	PTK2 protein tyrosine kinase 2	Mus musculus	223-226
11196148-9	2001	Confirming the relevance of this signaling pathway, treatment of Min/+ mice with (+)-catechin reduced the expression of phosphorylated FAK to a level similar to the wild-type littermate controls.	Catechin	81-93	PTK2 protein tyrosine kinase 2	Mus musculus	135-138
11312808-8	2000	The ERbeta-mediated estrogenic activities were stimulated by catechins.	Catechin	61-70	estrogen receptor 2	Homo sapiens	4-10
12094614-6	2001	Among the green tea catechins, epigallocatechin (0.5-1 microM) was the most effective in reducing IL-8 production and inhibiting angiogenesis.	Catechin	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
12094614-7	2001	These results suggest that consumption of green tea catechins or supplemental intake of vitamin E may have preventive effects on tumor development, mediated, at least in part, through inhibition of angiogenesis via suppression of IL-8 production.	Catechin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
11482900-1	2001	Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties.	Catechin	0-11	insulin	Homo sapiens	122-129
11482900-1	2001	Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties.	Catechin	81-90	insulin	Homo sapiens	122-129
11482900-8	2001	The strong inhibition of erythrocyte NHE1 (the ubiquitously present isoform) by epicatechin may have important implications.	Catechin	80-91	solute carrier family 9 member A1	Homo sapiens	37-41
11482900-9	2001	NHE1 inhibition could be one of the major mechanisms underlying the antiproliferative effects of catechins.	Catechin	97-106	solute carrier family 9 member A1	Homo sapiens	0-4
11962250-4	2001	Furthermore, we compared the potency of the different catechin components of green tea extract (GTE), including EGCG.	Catechin	54-62	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	83-86
12094614-0	2001	Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production.	Catechin	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
11219055-5	2000	The detection limit (S/N = 3) for each of the studied catechins was &lt; 0.5 ng mL-1.	Catechin	54-63	L1 cell adhesion molecule	Mus musculus	80-84
11312808-9	2000	In conclusion, some catechins, particularly EGCG, were antiestrogenic for ERalpha at higher doses, and co-estrogenic for ERalpha at lower doses and for ERbeta.	Catechin	20-29	estrogen receptor 1	Homo sapiens	74-81
11312808-9	2000	In conclusion, some catechins, particularly EGCG, were antiestrogenic for ERalpha at higher doses, and co-estrogenic for ERalpha at lower doses and for ERbeta.	Catechin	20-29	estrogen receptor 1	Homo sapiens	121-128
11312808-9	2000	In conclusion, some catechins, particularly EGCG, were antiestrogenic for ERalpha at higher doses, and co-estrogenic for ERalpha at lower doses and for ERbeta.	Catechin	20-29	estrogen receptor 2	Homo sapiens	152-158
11312811-0	2000	Inhibition of radical reaction of apolipoprotein B-100 and alpha-tocopherol in human plasma by green tea catechins.	Catechin	105-114	apolipoprotein B	Homo sapiens	34-54
11312811-2	2000	The concentrations of EC, EGC, ECg, EGCg, and Trolox for 50% inhibition (IC50) of apoB fragmentation were 39.1, 42.2, 14.6, 21.3, and 36.2 microM, respectively.	Catechin	22-24	apolipoprotein B	Homo sapiens	82-86
10929811-6	2000	Conjugated catechins were hydrolyzed by enzymes using sulfatase and beta-glucuronidase.	Catechin	11-20	glucuronidase beta	Homo sapiens	68-86
11064004-3	2000	In the present study, we investigated the effects of commercially available green tea extracts (GTEs) and individual tea catechins on the function of the AhR and on CYP1A gene expression in human hepatoma HepG2 cells and primary cultures of human hepatocytes.	Catechin	121-130	aryl hydrocarbon receptor	Homo sapiens	154-157
11064004-7	2000	Only (-)-epigallocatechin gallate (EGCG), the most abundant catechin in green tea, was able to inhibit TCDD-induced binding of the AhR to DNA and subsequent CYP1A transcription, however EGCG alone was less effective than GTEs.	Catechin	17-25	aryl hydrocarbon receptor	Homo sapiens	131-134
10950844-2	2000	(-)-Epicatechin, (+)-epicatechin, and (-)-epigallocatechin were good substrates for metabolic O-methylation by placental cytosolic COMT (150-500 pmol/mg of protein/min), but (-)-epicatechin gallate and (-)-epigallocatechin gallate were O-methylated at much lower rates (&lt;50 pmol/mg of protein/min).	Catechin	0-15	catechol-O-methyltransferase	Homo sapiens	131-135
10950844-2	2000	(-)-Epicatechin, (+)-epicatechin, and (-)-epigallocatechin were good substrates for metabolic O-methylation by placental cytosolic COMT (150-500 pmol/mg of protein/min), but (-)-epicatechin gallate and (-)-epigallocatechin gallate were O-methylated at much lower rates (&lt;50 pmol/mg of protein/min).	Catechin	17-32	catechol-O-methyltransferase	Homo sapiens	131-135
10950844-3	2000	When (-)-epicatechin was used as substrate, its O-methylation by human placental COMT showed dependence on incubation time, cytosolic protein concentration, incubation pH, and concentration of S-adenosyl-L-methionine (the methyl donor).	Catechin	5-20	catechol-O-methyltransferase	Homo sapiens	81-85
10950844-5	2000	Additional analysis revealed that COMT-catalyzed O-methylation of (-)-epicatechin and (-)-epigallocatechin was strongly inhibited in a concentration-dependent manner by S-adenosyl-L-homocysteine (IC(50) = 3.2-5.7 microM), a demethylated product of S-adenosyl-L-methionine.	Catechin	66-81	catechol-O-methyltransferase	Homo sapiens	34-38
10995031-5	2000	Quercetin and epicatechin were the strongest inhibitors of LDL oxidation catalyzed by 15-lipoxygenase; ascorbic acid was an effective inhibitor in the first 3 h of oxidation; and fivefold alpha-tocopherol-enriched LDL showed a partial inhibition of CE-OOH formation only after 4-6 h of incubation.	Catechin	14-25	arachidonate 15-lipoxygenase	Homo sapiens	86-101
10826917-8	2000	Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin.	Catechin	293-301	myeloperoxidase	Sus scrofa	6-9
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Catechin	311-319	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-135
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Catechin	324-335	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-135
10760511-5	2000	We conclude that catechins of the green tea possessing the gallate group in their chemical structure act as anticancer agents probably partly via their ability to suppress the tyrosine kinase activity of the PDGF-Rbeta.	Catechin	17-26	platelet derived growth factor receptor beta	Homo sapiens	208-218
10995031-9	2000	These results emphasize the inhibitory effect of the flavonoids quercetin and epicatechin on 15-lipoxygenase-mediated LDL lipid peroxidation.	Catechin	78-89	arachidonate 15-lipoxygenase	Homo sapiens	93-108
10719174-4	2000	The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).	Catechin	69-78	matrix metallopeptidase 2	Rattus norvegicus	18-22
10719174-4	2000	The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).	Catechin	150-165	matrix metallopeptidase 2	Rattus norvegicus	18-22
10719174-4	2000	The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).	Catechin	174-176	matrix metallopeptidase 2	Rattus norvegicus	18-22
10719174-4	2000	The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).	Catechin	233-245	matrix metallopeptidase 2	Rattus norvegicus	18-22
11142097-3	2000	The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth.	Catechin	85-93	BTG anti-proliferation factor 2	Homo sapiens	31-34
10706406-3	2000	Three polyphenol-containing anti-oxidant compounds [catechin, epigallocatechin gallate (EGCG) and quercetin] inhibited CK-II activity (phosphorylation of these ribosomal P proteins) in a dose-dependent manner in vitro.	Catechin	52-60	casein kinase 2 alpha 1	Homo sapiens	119-124
11142097-3	2000	The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth.	Catechin	95-106	BTG anti-proliferation factor 2	Homo sapiens	31-34
10197308-6	1998	Colonic myeloperoxidase (MPO) activity, which is a marker of neutrophil infiltration into the colonic mucosa, was lower in the groups that had been given catechins and alpha-tocopherol.	Catechin	154-163	myeloperoxidase	Rattus norvegicus	8-23
10580284-3	1999	Two of the isoforms, designated PPO(a) and PPO(d), differed in their N-terminal sequence, tryptic peptide map and substrate affinity for (+)-catechin, but exhibited similarity in their molecular mass under denaturing conditions, pH optimum and kinetic behaviour toward 4-methyl catechol.	Catechin	137-149	protoporphyrinogen oxidase	Homo sapiens	32-35
10580284-3	1999	Two of the isoforms, designated PPO(a) and PPO(d), differed in their N-terminal sequence, tryptic peptide map and substrate affinity for (+)-catechin, but exhibited similarity in their molecular mass under denaturing conditions, pH optimum and kinetic behaviour toward 4-methyl catechol.	Catechin	137-149	protoporphyrinogen oxidase	Homo sapiens	43-46
10470285-4	1999	Various tea polyphenols derived from green tea and black tea induced growth inhibition and apoptosis of human stomach cancer cell line KATO III, and inhibition of tumor necrosis factor-alpha (TNF-alpha) release from the cells, in the order of (-)-epicatechin gallate (ECG), EGCG, (-)-epigallocatechin (EGC), teaflavins (TF) and (-)-epicatechin (EC).	Catechin	243-258	tumor necrosis factor	Homo sapiens	192-201
10216249-7	1999	(-)Epicatechin (100 microM) significantly increased the tissue content of cyclic GMP and NG-nitro-L-arginine (100 microM) or removal of the endothelium abolished this increase.	Catechin	3-14	5'-nucleotidase, cytosolic II	Homo sapiens	81-84
9892181-1	1999	The study on incorporation of [3H](-)-epigallocatechin gallate (EGCG) into human lung cancer cell line PC-9 indicated that the [3H]EGCG incorporation was significantly enhanced by (-)-epicatechin, an inert tea polyphenol without a galloyl moiety.	Catechin	180-195	proprotein convertase subtilisin/kexin type 9	Homo sapiens	103-107
9892181-2	1999	(-)-Epicatechin enhanced apoptosis, growth inhibition of PC-9 cells, and inhibition of tumor necrosis factor-alpha release from BALB/c-3T3 cells by EGCG and other tea polyphenols with a galloyl moiety in a dose-dependent manner.	Catechin	0-15	proprotein convertase subtilisin/kexin type 9	Homo sapiens	57-61
9892181-2	1999	(-)-Epicatechin enhanced apoptosis, growth inhibition of PC-9 cells, and inhibition of tumor necrosis factor-alpha release from BALB/c-3T3 cells by EGCG and other tea polyphenols with a galloyl moiety in a dose-dependent manner.	Catechin	0-15	tumor necrosis factor	Homo sapiens	87-114
10939849-1	1999	All C-H and O-H bond dissociation enthalpies (BDE"s) in catechins, (-)-epigallocatechin) were calculated by semi-empirical molecular orbital calculation using the SPARTAN program.	Catechin	56-65	homeobox D13	Homo sapiens	46-49
10939849-2	1999	The BDE"s of benzyl hydrogens (C-2 position in catechins) were found to be quite low.	Catechin	47-56	homeobox D13	Homo sapiens	4-7
10939849-2	1999	The BDE"s of benzyl hydrogens (C-2 position in catechins) were found to be quite low.	Catechin	47-56	complement C2	Homo sapiens	31-34
10794635-5	1999	Ester-type catechins (ECg and EGCg) and theaflavin strongly suppressed the gelatin degradation mediated by matrix metalloproteinase (MMP) 2 and MMP-9, which were secreted into the conditioned medium of HT1080 cells.	Catechin	11-20	matrix metallopeptidase 2	Homo sapiens	107-139
10794635-5	1999	Ester-type catechins (ECg and EGCg) and theaflavin strongly suppressed the gelatin degradation mediated by matrix metalloproteinase (MMP) 2 and MMP-9, which were secreted into the conditioned medium of HT1080 cells.	Catechin	11-20	matrix metallopeptidase 9	Homo sapiens	144-149
10524352-1	1999	The purpose of this study was to investigate the effects of dietary green tea catechin on phospholipase A2 (PLA2) activity and the antithrombotic reaction of platelets in streptozotocin (STZ)-diabetic rats.	Catechin	78-86	phospholipase A2 group IB	Rattus norvegicus	90-106
10524352-1	1999	The purpose of this study was to investigate the effects of dietary green tea catechin on phospholipase A2 (PLA2) activity and the antithrombotic reaction of platelets in streptozotocin (STZ)-diabetic rats.	Catechin	78-86	phospholipase A2 group IB	Rattus norvegicus	108-112
10552467-6	1999	When the plasma from proanthocyanidin-administered rat was hydrolyzed by sulfatase and beta-glucuronidase following analysis by high-performance liquid chromatography with electrochemical detection, metabolites of proanthocyanidins occurred in rat plasma at 15 min after administration, three peaks of which were identified as gallic acid, (+)-catechin, and (-)-epicatechin.	Catechin	340-352	glucuronidase, beta	Rattus norvegicus	87-105
10552467-6	1999	When the plasma from proanthocyanidin-administered rat was hydrolyzed by sulfatase and beta-glucuronidase following analysis by high-performance liquid chromatography with electrochemical detection, metabolites of proanthocyanidins occurred in rat plasma at 15 min after administration, three peaks of which were identified as gallic acid, (+)-catechin, and (-)-epicatechin.	Catechin	358-373	glucuronidase, beta	Rattus norvegicus	87-105
10552469-1	1999	Two catechin derivatives (C-1 and C-2) with potent antiallergic activity were isolated from Taiwanese oolong tea by HPLC techniques.	Catechin	4-12	oogenesin 1	Mus musculus	26-37
10563851-7	1999	In a membrane lipid peroxidation system, the effectiveness of the antioxidant was dependent on the catalyst: In the presence of H(2)O(2)-activated myoglobin, the inhibition efficiency of the antioxidant was malvidin 3-glucoside &gt; catechin &gt; malvidin &gt; resveratrol.	Catechin	233-241	myoglobin	Homo sapiens	147-156
10197308-6	1998	Colonic myeloperoxidase (MPO) activity, which is a marker of neutrophil infiltration into the colonic mucosa, was lower in the groups that had been given catechins and alpha-tocopherol.	Catechin	154-163	myeloperoxidase	Rattus norvegicus	25-28
10225059-1	1998	On analysing the effect of catechin on intestinal lipid metabolism, an increase in the concentration of cholesterol in the duodenum and jejunum was observed along with an increase in the HMGCoA reductase activity.	Catechin	27-35	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	187-203
9860051-1	1998	The effect of ad libitum oral-administration of (-)catechin solution on ischemia-reperfusion-induced cell death of hippocampal CA1 in the gerbil was histologically examined.	Catechin	51-59	carbonic anhydrase 1	Homo sapiens	127-130
9860051-5	1998	From these results, it was suggested that orally administered (-)catechin was absorbed, passed through the blood-brain barrier and that delayed neuronal death of hippocampal CA1 after ischemia-reperfusion was prevented due to its antioxidant activities.	Catechin	65-73	carbonic anhydrase 1	Homo sapiens	174-177
9919487-8	1998	Thus if antioxidants like catechin were supplementation, the activity of PLA2 and PE hydrolysis can be altered and the accumulation of lipid peroxide would be decreased.	Catechin	26-34	phospholipase A2 group IB	Rattus norvegicus	73-77
9919487-9	1998	Therefore we concluded that the antioxidant catechin for diabetic animals can significantly reduce PLA2 activities and lipid peroxide formation.	Catechin	44-52	phospholipase A2 group IB	Rattus norvegicus	99-103
10225059-3	1998	Binding of catechin with cholesterol in the lumen, reduces the availability of cholesterol for absorption which may in turn stimulate cholesterol biosynthesis and a rise in the HMGCoA reductase activity.	Catechin	11-19	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-193
10554249-4	1998	In the conditions of this study, the gallate ester of (-)-epicatechin is more unstable than (-)-epicatechin; inversely, kinetic decompositions of dimeric procyanidins B2 and B4 are much more important than those of their gallate esters.	Catechin	54-69	immunoglobulin kappa variable 5-2	Homo sapiens	167-176
9287415-2	1997	All of the flavanones tested as well as a flavan, epicatechin, protected L-929 cells from TNF-induced cell death of the flavanones tested, hesperetin, isosakuranetin, and pinocembrin failed to modify TNF cytotoxicity, but the 3",4"-dihydroxyflavanones, eriodictyol and taxifolin, showed a protective effect.	Catechin	50-61	tumor necrosis factor	Mus musculus	90-93
7653998-8	1995	At 12 mg, gallic acid, Aleppo gall tannic acid (TA), catechin, and loblolly pine bark CT inhibit the most CPBA-induced ODC activity.	Catechin	53-61	ornithine decarboxylase, structural 1	Mus musculus	119-122
9093380-0	1997	Inhibition of PhIP mutagenicity by catechins, and by theaflavins and gallate esters.	Catechin	35-44	pleckstrin homology domain interacting protein	Rattus norvegicus	14-18
10325618-5	1997	As a natural antioxidant, tea contains several antioxidants, such as ascorbic acid and catechins, which removed NO2- from tap water effectively.	Catechin	87-96	SEC14 like lipid binding 2	Homo sapiens	122-125
8575811-0	1995	Insulin-mimetic effect of (-) epicatechin on osmotic fragility of human erythrocytes.	Catechin	26-41	insulin	Homo sapiens	0-7
8575811-1	1995	(-) Epicatechin, a benzopyran extracted from the bark of Pterocarpus marsupium, is reported to have insulin like activity.	Catechin	0-15	insulin	Homo sapiens	100-107
8575811-2	1995	The present work is undertaken to study the effect of insulin on erythrocyte osmotic fragility (OF) and then to evaluate the insulin-like role of (-) epicatechin on human erythrocytes.	Catechin	146-161	insulin	Homo sapiens	125-132
7665919-6	1995	Pretreatment of the skin with GTP or individual epicatechin derivatives (ECDs) present therein, 30 min before that of TPA, resulted in a significant inhibition of enhanced expression of epidermal IL-1 alpha mRNA caused by skin application of TPA.	Catechin	48-59	interleukin 1 alpha	Mus musculus	196-206
9310136-4	1997	EGC and ECG inhibited the growth of PC-9 cells as potently as did EGCG, but EC did not show significant growth inhibition.	Catechin	8-10	proprotein convertase subtilisin/kexin type 9	Homo sapiens	36-40
9255589-3	1997	In this article, tea catechins will be used as an example to illustrate current research in this area.	Catechin	21-30	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	17-20
9154941-5	1997	Measurement of dissociation constants indicates that the larger and more complex polyphenols interact more strongly with the PRP fragment; the order of binding affinity was determined as procyanidin dimer B-2 &gt; pentagalloylglucose &gt; trigalloylglucose &gt;&gt; proanthocyanidin monomer (-)-epicatechin approximately propyl gallate.	Catechin	291-306	prion protein	Homo sapiens	125-128
9125123-6	1997	The catechin polyphenols were also found to offer protection from peroxynitrite-induced modification of critical amino acids of apolipoprotein B-100 of LDL which contribute towards its surface charge.	Catechin	4-12	apolipoprotein B	Homo sapiens	128-148
9591194-9	1997	Several epicatechin derivatives (polyphenols) present in green tea have been shown to possess anticarcinogenic activity; the most active is (-)-epigallocatechin-3-gallate, which is also the major constituent of GTP.	Catechin	8-19	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-66
9375410-1	1997	The separation and detection of biologically active green tea catechins has been accomplished using capillary liquid chromatography/electrospray mass spectrometry (cLC/ESI-MS).	Catechin	62-71	Charcot-Leyden crystal galectin	Homo sapiens	164-167
9375410-2	1997	Microscale determination (approximately 20 ng) of all six catechins in a green tea infusion, and the most extensively studied catechin, (-)epigallocatechin gallate (EGCG), in human plasma is demonstrated by cLC/ESI-MS with selected ion monitoring of protonated molecular ions.	Catechin	58-67	Charcot-Leyden crystal galectin	Homo sapiens	207-210
9375410-2	1997	Microscale determination (approximately 20 ng) of all six catechins in a green tea infusion, and the most extensively studied catechin, (-)epigallocatechin gallate (EGCG), in human plasma is demonstrated by cLC/ESI-MS with selected ion monitoring of protonated molecular ions.	Catechin	58-66	Charcot-Leyden crystal galectin	Homo sapiens	207-210
8980692-7	1996	Experiments comparing NOP direct and plant-activated mutagenic activity to different Salmonella strains (in the presence and absence of (+)-catechin) suggest that (+)-catechin may inhibit the mutagenic process by limiting O-acetyltransferase (OAT) activity in Salmonella.	Catechin	163-175	CAS1 domain containing 1	Homo sapiens	222-241
8073090-5	1994	At a dose of 10 mumol, the epicatechin trimer also inhibits TPA-induced ODC activity and HPx production to a greater degree than 10-30 mumol of epicatechin.	Catechin	27-38	ornithine decarboxylase, structural 1	Mus musculus	72-75
21559587-2	1994	Topical applications of catechin fail to alter the hydroperoxide response to TPA but inhibit the induction of ornithine decarboxylase (ODC) activity and, to a lesser degree, the stimulation of RNA, protein, and DNA synthesis caused by this tumor promoter.	Catechin	24-32	ornithine decarboxylase, structural 1	Mus musculus	110-133
21559587-2	1994	Topical applications of catechin fail to alter the hydroperoxide response to TPA but inhibit the induction of ornithine decarboxylase (ODC) activity and, to a lesser degree, the stimulation of RNA, protein, and DNA synthesis caused by this tumor promoter.	Catechin	24-32	ornithine decarboxylase, structural 1	Mus musculus	135-138
7898128-6	1994	injection of catechin to male Swiss mice induced increased forestomach and hepatic glutathione S-transferase (GST) activity when compared to controls.	Catechin	13-21	hematopoietic prostaglandin D synthase	Mus musculus	83-108
7898128-6	1994	injection of catechin to male Swiss mice induced increased forestomach and hepatic glutathione S-transferase (GST) activity when compared to controls.	Catechin	13-21	hematopoietic prostaglandin D synthase	Mus musculus	110-113
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Catechin	54-62	ornithine decarboxylase, structural 1	Mus musculus	131-154
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Catechin	54-62	ornithine decarboxylase, structural 1	Mus musculus	156-159
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Catechin	82-93	ornithine decarboxylase, structural 1	Mus musculus	131-154
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Catechin	82-93	ornithine decarboxylase, structural 1	Mus musculus	156-159
8481892-6	1993	Elevations of almost 2-4-fold in the intracellular reduced glutathione and related enzymes viz., glutathione reductase and glutathione S-transferase of sarcoma-180 tumour cells were noted in the presence of 1 microgram/ml of (-)-epicatechin, further highlighting its antiproliferative effect.	Catechin	225-240	glutathione reductase	Mus musculus	97-118
8481892-6	1993	Elevations of almost 2-4-fold in the intracellular reduced glutathione and related enzymes viz., glutathione reductase and glutathione S-transferase of sarcoma-180 tumour cells were noted in the presence of 1 microgram/ml of (-)-epicatechin, further highlighting its antiproliferative effect.	Catechin	225-240	hematopoietic prostaglandin D synthase	Mus musculus	123-148
7507456-14	1993	which reduces cytochrome c to ferrocytochrome c. (+) Catechin and (-) epicatechin inhibited the reduction of cytochrome c in a concentration dependent manner.	Catechin	53-61	cytochrome c, somatic	Homo sapiens	14-26
7507456-14	1993	which reduces cytochrome c to ferrocytochrome c. (+) Catechin and (-) epicatechin inhibited the reduction of cytochrome c in a concentration dependent manner.	Catechin	53-61	cytochrome c, somatic	Homo sapiens	35-47
7507456-14	1993	which reduces cytochrome c to ferrocytochrome c. (+) Catechin and (-) epicatechin inhibited the reduction of cytochrome c in a concentration dependent manner.	Catechin	67-81	cytochrome c, somatic	Homo sapiens	14-26
7507456-14	1993	which reduces cytochrome c to ferrocytochrome c. (+) Catechin and (-) epicatechin inhibited the reduction of cytochrome c in a concentration dependent manner.	Catechin	67-81	cytochrome c, somatic	Homo sapiens	35-47
24419836-8	1993	It was optimum at pH 7.0 and 50 C and was highly specific for catechin, with a Km of 4 muM.	Catechin	62-70	latexin	Homo sapiens	87-90
1329770-3	1992	By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibition of GR: anthocyanidin &gt; dihydroflavonol = chalcone &gt; flavonol &gt; catechin.	Catechin	245-253	glutathione-disulfide reductase	Homo sapiens	176-178
1394738-2	1992	After 1.5 h preincubation, d-CTC was added at doses of 0.1-5.0 mg/ml to culture medium together with 10 mmol/L CCl4 or 5 mmol/L d-GalN, respectively.	Catechin	27-32	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
1617628-0	1992	Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.	Catechin	171-182	ornithine decarboxylase, structural 1	Mus musculus	64-87
1394738-2	1992	After 1.5 h preincubation, d-CTC was added at doses of 0.1-5.0 mg/ml to culture medium together with 10 mmol/L CCl4 or 5 mmol/L d-GalN, respectively.	Catechin	27-32	galanin and GMAP prepropeptide	Rattus norvegicus	130-134
1394738-4	1992	The results showed that d-CTC at doses of 0.6 to 5.0 mg/ml could protect the hepatocytes against the toxic effects of CCl4 and d-GalN.	Catechin	24-29	C-C motif chemokine ligand 4	Rattus norvegicus	118-122
1394738-4	1992	The results showed that d-CTC at doses of 0.6 to 5.0 mg/ml could protect the hepatocytes against the toxic effects of CCl4 and d-GalN.	Catechin	24-29	galanin and GMAP prepropeptide	Rattus norvegicus	129-133
1394738-5	1992	At the higher doses (2.5-5.0 mg/ml), d-CTC showed weak inhibition of LDH and GPT activities, but these did not influence its anti-hepatotoxic activity.	Catechin	37-42	glutamic--pyruvic transaminase	Rattus norvegicus	77-80
1706539-7	1991	Cyanidanol pretreatment at 48, 24, and 2 hr before CCl4 administration to rats maintained on CD diet resulted in 100 or 70% animal survival, for CCl4 (L) or the standard dose of CCl4, respectively.	Catechin	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
1706539-7	1991	Cyanidanol pretreatment at 48, 24, and 2 hr before CCl4 administration to rats maintained on CD diet resulted in 100 or 70% animal survival, for CCl4 (L) or the standard dose of CCl4, respectively.	Catechin	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
1901781-6	1991	Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin.	Catechin	20-29	plasminogen activator, tissue	Mus musculus	108-112
1706539-16	1991	Cyanidanol pretreatment to CD + CCl4 combination-treated rats did not significantly prevent the decline in hepatic ATP and glycogen levels.	Catechin	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	32-36
1706540-1	1991	Previous work has shown that chlordecone (CD)-amplified CCl4 hepatotoxicity and lethality can be mitigated by pretreatment with cyanidanol.	Catechin	128-138	C-C motif chemokine ligand 4	Rattus norvegicus	56-60
1706540-2	1991	These studies also revealed that stimulated hepatocellular regeneration might play an important role in the cyanidanol protection of CD-amplified CCl4 toxicity.	Catechin	108-118	C-C motif chemokine ligand 4	Rattus norvegicus	146-150
1706540-7	1991	Cyanidanol-stimulated [3H]thymidine incorporation was highly suppressed in rats receiving the CD + CCl4 standard dose combination treatment up to 36 hr, but after this time point a marked increase was observed.	Catechin	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	99-103
1706540-8	1991	Hepatocellular regeneration, quantified histomorphometrically as volume density of cells in metaphase, was progressively increased in rats protected from CD + CCl4 interaction by cyanidanol, starting at 36 hr and lasting until 72 hr.	Catechin	179-189	C-C motif chemokine ligand 4	Rattus norvegicus	159-163
1706540-13	1991	With rats receiving CD + CCl4(L) combination, the [3H]thymidine incorporation at 48 hr was less than 50% of the increase of cyanidanol-protected rats.	Catechin	124-134	C-C motif chemokine ligand 4	Rattus norvegicus	25-29
1706540-14	1991	Cyanidanol pretreatment to the CD + CCl4 group of rats prevented the decrease in the hepatic DNA levels.	Catechin	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	36-40
33989703-0	2021	(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells.	Catechin	0-15	androgen receptor	Homo sapiens	57-74
33989703-0	2021	(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells.	Catechin	0-15	solute carrier family 39 member 9	Homo sapiens	76-80
33989703-5	2021	(-)-Epicatechin also activated androgen-dependent ZIP9 signaling pathways, inducing decreases in cAMP production and elevating intracellular free zinc levels, while (+)-catechin typically lacked these actions.	Catechin	7-15	solute carrier family 39 member 9	Homo sapiens	50-54
33989703-6	2021	Both (-)-epicatechin and (+)-catechin also bound to cell membranes of MDA-MB-468 breast cancer cells (nAR-null, high ZIP9 expression).	Catechin	7-20	solute carrier family 39 member 9	Homo sapiens	117-121
33989703-0	2021	(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells.	Catechin	0-15	solute carrier family 39 member 9	Homo sapiens	82-89
33989703-6	2021	Both (-)-epicatechin and (+)-catechin also bound to cell membranes of MDA-MB-468 breast cancer cells (nAR-null, high ZIP9 expression).	Catechin	12-20	solute carrier family 39 member 9	Homo sapiens	117-121
33989703-8	2021	Moreover, knockdown of ZIP9 expression in MDA-MB-468 cells with siRNA decreased the displacement of [3H]-testosterone binding by both catechins and blocked the apoptotic and free zinc responses to testosterone and (-)-epicatechin.	Catechin	134-143	solute carrier family 39 member 9	Homo sapiens	23-27
33989703-2	2021	Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated.	Catechin	26-41	androgen receptor	Homo sapiens	77-94
33989703-8	2021	Moreover, knockdown of ZIP9 expression in MDA-MB-468 cells with siRNA decreased the displacement of [3H]-testosterone binding by both catechins and blocked the apoptotic and free zinc responses to testosterone and (-)-epicatechin.	Catechin	214-229	solute carrier family 39 member 9	Homo sapiens	23-27
33989703-9	2021	The results indicate (-)-epicatechin is a potent ZIP9 agonist in breast and prostate cancer cells.	Catechin	25-36	solute carrier family 39 member 9	Homo sapiens	49-53
33989703-2	2021	Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated.	Catechin	26-41	solute carrier family 39 member 9	Homo sapiens	102-109
33989703-2	2021	Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated.	Catechin	33-41	androgen receptor	Homo sapiens	77-94
33989703-2	2021	Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated.	Catechin	33-41	solute carrier family 39 member 9	Homo sapiens	96-100
33989703-3	2021	Both (-)-epicatechin and (+)-catechin were effective competitors of [3H]-testosterone binding to PC-3 prostate cancer cells (nuclear androgen receptor-negative, nAR-null) overexpressing ZIP9 (PC3-ZIP9), with relative binding affinities of 75% and 28% that of testosterone, respectively.	Catechin	9-20	androgen receptor	Homo sapiens	133-150
33989703-3	2021	Both (-)-epicatechin and (+)-catechin were effective competitors of [3H]-testosterone binding to PC-3 prostate cancer cells (nuclear androgen receptor-negative, nAR-null) overexpressing ZIP9 (PC3-ZIP9), with relative binding affinities of 75% and 28% that of testosterone, respectively.	Catechin	9-20	solute carrier family 39 member 9	Homo sapiens	186-190
33989703-3	2021	Both (-)-epicatechin and (+)-catechin were effective competitors of [3H]-testosterone binding to PC-3 prostate cancer cells (nuclear androgen receptor-negative, nAR-null) overexpressing ZIP9 (PC3-ZIP9), with relative binding affinities of 75% and 28% that of testosterone, respectively.	Catechin	12-20	androgen receptor	Homo sapiens	133-150
33989703-3	2021	Both (-)-epicatechin and (+)-catechin were effective competitors of [3H]-testosterone binding to PC-3 prostate cancer cells (nuclear androgen receptor-negative, nAR-null) overexpressing ZIP9 (PC3-ZIP9), with relative binding affinities of 75% and 28% that of testosterone, respectively.	Catechin	12-20	solute carrier family 39 member 9	Homo sapiens	186-190
33989703-4	2021	(-)-Epicatechin (200 nM) mimicked the effects of 100 nM testosterone in inducing apoptosis of PC3-ZIP9 cells, whereas (+)-catechin (concentration range 200 nM-1000 nM) did not significantly increase apoptosis and instead blocked the apoptotic response to testosterone.	Catechin	4-15	solute carrier family 39 member 9	Homo sapiens	94-102
33989703-4	2021	(-)-Epicatechin (200 nM) mimicked the effects of 100 nM testosterone in inducing apoptosis of PC3-ZIP9 cells, whereas (+)-catechin (concentration range 200 nM-1000 nM) did not significantly increase apoptosis and instead blocked the apoptotic response to testosterone.	Catechin	7-15	solute carrier family 39 member 9	Homo sapiens	94-102
33989703-5	2021	(-)-Epicatechin also activated androgen-dependent ZIP9 signaling pathways, inducing decreases in cAMP production and elevating intracellular free zinc levels, while (+)-catechin typically lacked these actions.	Catechin	0-15	solute carrier family 39 member 9	Homo sapiens	50-54
24760105-11	2014	Further results indicated catechin obviously inhibited immune activation, regulated unbalanced levels of IL-17/IL-10, and reversed abnormal polarization of TH17 as well as Treg in peripheral blood and spleen.	Catechin	26-34	interleukin 17A	Rattus norvegicus	105-110
24760105-11	2014	Further results indicated catechin obviously inhibited immune activation, regulated unbalanced levels of IL-17/IL-10, and reversed abnormal polarization of TH17 as well as Treg in peripheral blood and spleen.	Catechin	26-34	interleukin 10	Rattus norvegicus	111-116
20234037-11	2009	CONCLUSIONS: In this study, we demonstrated that EGCG, the major green tea catechin, induced HO-1 expression in cultured neurons, possibly by activation of the transcription factor Nrf2, and by this mechanism was able to protect against oxidative stress-induced cell death.	Catechin	75-83	heme oxygenase 1	Rattus norvegicus	93-97
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	Catechin	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
7480211-0	1995	Effects of catechins on the mouse tumor cell adhesion to fibronectin.	Catechin	11-20	fibronectin 1	Mus musculus	57-68
7480211-1	1995	We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL and melanoma B16F10 cells to the fibronectin substratum.	Catechin	37-46	fibronectin 1	Mus musculus	124-135
34536779-0	2022	Estimating the catechin concentrations of new shoots in green tea fields using ground-based hyperspectral imagery.	Catechin	15-23	Spi-1 proto-oncogene	Homo sapiens	39-41
34536779-1	2022	Hyperspectral imagery was applied to estimating non-galloyl (EC, EGC) and galloyl (ECG, EGCG) types of catechins in new shoots of green tea.	Catechin	103-112	Spi-1 proto-oncogene	Homo sapiens	100-102
34536779-1	2022	Hyperspectral imagery was applied to estimating non-galloyl (EC, EGC) and galloyl (ECG, EGCG) types of catechins in new shoots of green tea.	Catechin	103-112	Spi-1 proto-oncogene	Homo sapiens	127-129
34536779-3	2022	The models could explain each type of catechin with a precision of more than 0.79, with a few exceptions.	Catechin	38-46	Spi-1 proto-oncogene	Homo sapiens	35-37
34536779-3	2022	The models could explain each type of catechin with a precision of more than 0.79, with a few exceptions.	Catechin	38-46	Spi-1 proto-oncogene	Homo sapiens	64-66
34536779-5	2022	The prediction models using both CF and OF data (hyperspectral reflectances, and concentrations of catechins) had a precision of more than 0.76 except for the non-galloyl-type catechins as a group and EGC alone.	Catechin	99-108	Spi-1 proto-oncogene	Homo sapiens	96-98
34536779-5	2022	The prediction models using both CF and OF data (hyperspectral reflectances, and concentrations of catechins) had a precision of more than 0.76 except for the non-galloyl-type catechins as a group and EGC alone.	Catechin	99-108	Spi-1 proto-oncogene	Homo sapiens	126-128
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	Catechin	54-62	arachidonate 5-lipoxygenase	Homo sapiens	191-205
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	Catechin	54-62	arachidonate 5-lipoxygenase	Homo sapiens	207-212
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	Catechin	54-62	NLR family pyrin domain containing 3	Homo sapiens	218-223
34942397-10	2022	In addition to the well-known ACE2 inhibitors that were identified in previous studies, this study revealed for the first time that epicatechin from Hypericum perforatum provided a better static and dynamic inhibition for ACE2 with highly favourable pharmacokinetic properties than the other known ACE2 inhibiting compounds.	Catechin	132-143	angiotensin converting enzyme 2	Homo sapiens	30-34
34942397-10	2022	In addition to the well-known ACE2 inhibitors that were identified in previous studies, this study revealed for the first time that epicatechin from Hypericum perforatum provided a better static and dynamic inhibition for ACE2 with highly favourable pharmacokinetic properties than the other known ACE2 inhibiting compounds.	Catechin	132-143	angiotensin converting enzyme 2	Homo sapiens	222-226
34942397-12	2022	In vitro experiments are required to validate epicatechin effectiveness against the activity of the human ACE2 receptor.	Catechin	46-57	angiotensin converting enzyme 2	Homo sapiens	106-110
34812946-1	2022	This review summarizes experimental evidence on the beneficial effects of ( -)-epicatechin (EC) attenuating major cardiometabolic risk factors, i.e., dyslipidemias, obesity (adipose tissue dysfunction), hyperglycemia (insulin resistance), and hypertension (endothelial dysfunction).	Catechin	74-90	insulin	Homo sapiens	218-225
34493433-0	2022	Corrigendum to "Cerebro-protection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways" (Free Radic.	Catechin	47-62	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
34896463-1	2022	The study aimed to develop pre-gelatinized starch-based orally disintegrating films (ODFs) containing catechin/beta-cyclodextrin (CAT/beta-CD) complex and to evaluate the influence of the complex on the physicochemical properties of the ODFs.	Catechin	102-110	chloramphenicol acetyltransferase	Staphylococcus aureus	130-133
34845949-0	2022	Catechin regulates miR-182/GGPPS1 signaling pathway and inhibits LPS-induced acute lung injury in mice.	Catechin	0-8	microRNA 182	Mus musculus	19-26
34845949-6	2022	Notably, miR-182/GGPPS1 signaling pathway was reactivated upon catechin administration, which was essential for the catechin-induced protective effect against ALI.	Catechin	63-71	microRNA 182	Mus musculus	9-16
34845949-6	2022	Notably, miR-182/GGPPS1 signaling pathway was reactivated upon catechin administration, which was essential for the catechin-induced protective effect against ALI.	Catechin	116-124	microRNA 182	Mus musculus	9-16
34845949-7	2022	CONCLUSION: catechin regulates miR-182/GGPPS1 signaling pathway and efficaciously ameliorates LPS-induced acute lung injury in mice model, which provided a promising therapeutic strategy in ALI and ARDS.	Catechin	12-20	microRNA 182	Mus musculus	31-38
34812946-1	2022	This review summarizes experimental evidence on the beneficial effects of ( -)-epicatechin (EC) attenuating major cardiometabolic risk factors, i.e., dyslipidemias, obesity (adipose tissue dysfunction), hyperglycemia (insulin resistance), and hypertension (endothelial dysfunction).	Catechin	92-94	insulin	Homo sapiens	218-225
34960099-1	2021	It is well known that supplementation with high protein after exercise can effectively promote muscle synthesis and repair, while green tea is rich in catechins that have antioxidant effects.	Catechin	151-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	136-139
34976093-0	2021	Hepatoprotective Effects of (-) Epicatechin in CCl4-Induced Toxicity Model Are Mediated via Modulation of Oxidative Stress Markers in Rats.	Catechin	32-43	C-C motif chemokine ligand 4	Rattus norvegicus	47-51
34976093-2	2021	The current study was designed to evaluate the potential role of antioxidant mechanisms in the hepatoprotective properties of EP using the carbon tetrachloride (CCl4)-induced acute liver injury model.	Catechin	126-128	C-C motif chemokine ligand 4	Rattus norvegicus	161-165
34976093-9	2021	Conclusions: The results of this study revealed a significant protective efficacy of EP against CCl4-induced liver injury, which was potentially mediated via upregulation of antioxidant enzymes and direct scavenging effects of the compound against free radicals.	Catechin	85-87	C-C motif chemokine ligand 4	Rattus norvegicus	96-100
34969954-0	2021	Determination of tyrosinase-cyanidin-3-O-glucoside and (-/+)-catechin binding modes reveal mechanistic differences in tyrosinase inhibition.	Catechin	61-69	tyrosinase	Mus musculus	118-128
34969954-2	2021	Natural products, such as cyanidin-3-O-glucoside and (-/+)-catechin, are considered safe and non-toxic food additives in tyrosinase inhibition but their ambiguous inhibitory mechanism against tyrosinase is still elusive.	Catechin	59-67	tyrosinase	Mus musculus	121-131
34969954-2	2021	Natural products, such as cyanidin-3-O-glucoside and (-/+)-catechin, are considered safe and non-toxic food additives in tyrosinase inhibition but their ambiguous inhibitory mechanism against tyrosinase is still elusive.	Catechin	59-67	tyrosinase	Mus musculus	192-202
34969954-3	2021	Thus, we presented the mechanistic insights into tyrosinase with cyanidin-3-O-glucoside and (-/+)-catechin using computational simulations and in vitro assessment.	Catechin	98-106	tyrosinase	Mus musculus	49-59
34969954-6	2021	Particularly, metal chelation via catechol group linked with the free 3-OH group on the unconjugated dihydropyran heterocycle chain was elucidated to contribute to tyrosinase inhibition by (-/+)-catechin against cyanidin-3-O-glucoside.	Catechin	195-203	tyrosinase	Mus musculus	164-174
34969954-8	2021	Conclusively, (-/+)-catechin was observed for substantial tyrosinase inhibition and advocated for further investigation for drug development against tyrosinase-associated diseases.	Catechin	20-28	tyrosinase	Mus musculus	58-68
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	93-104	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	109-117	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	109-117	angiotensin converting enzyme 2	Homo sapiens	248-279
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	109-117	angiotensin converting enzyme 2	Homo sapiens	281-285
34929173-0	2022	Structural determinants of the interactions of catechins with Abeta oligomers and lipid membranes.	Catechin	47-56	amyloid beta precursor protein	Homo sapiens	62-67
34929173-4	2022	Here, we assemble a catechin library by combining several naturally occurring chemical modifications and, using a coupled NMR-statistical approach, we map at atomic resolution the interactions of such library with the Alzheimer"s associated Abeta oligomers and model membranes.	Catechin	20-28	amyloid beta precursor protein	Homo sapiens	241-246
34929173-6	2022	Interestingly, we find that the positive cooperativity is more prevalent for Abeta oligomers than membrane binding, and that the determinants underlying catechin recognition by membranes are markedly different from those dissected for Abeta oligomers.	Catechin	153-161	amyloid beta precursor protein	Homo sapiens	77-82
34959345-8	2021	Cyanidin-3O-sophoroside, catechin, naringenin, kuromanin and caffeic acid increased the ATPase activity of Pgp, while they had only a weaker effect on the intracellular accumulation of fluorescent Pgp substrates.	Catechin	25-33	ATP binding cassette subfamily B member 1	Homo sapiens	107-110
34597896-0	2021	Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.	Catechin	56-64	ATP binding cassette subfamily B member 1	Homo sapiens	112-126
34597896-9	2021	In summary, methylated C 25 and EC 31 derivatives represent a new class of potent, specific and non-toxic P-gp modulator.	Catechin	32-34	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
34182296-1	2021	Formation of catechins-human serum albumin (HSA) complex contributes to stably transporting catechins and regulating their bioavailability.	Catechin	92-101	albumin	Homo sapiens	13-42
34182296-1	2021	Formation of catechins-human serum albumin (HSA) complex contributes to stably transporting catechins and regulating their bioavailability.	Catechin	92-101	albumin	Homo sapiens	44-47
34182296-3	2021	The unique structural modification with an N-ethyl-2-pyrrolidinone ring at catechins from these flavoalkaloids has raised our interest in their HSA binding affinity.	Catechin	75-84	albumin	Homo sapiens	144-147
34182296-10	2021	Present study will help us to understand the interaction mechanism between flavoalkaloids and HSA, shedding light on structural modification of common catechins to enhance the stability, bioavailability and bioactivities.	Catechin	151-160	albumin	Homo sapiens	94-97
34473289-7	2021	The evaluation of adenosine monophosphate-activated protein kinase (AMPK) and Akt phosphorylation and mTOR expression indicates that EC modulates these pathways, resulting in the inhibition of cell proliferation.	Catechin	133-135	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-66
34473289-7	2021	The evaluation of adenosine monophosphate-activated protein kinase (AMPK) and Akt phosphorylation and mTOR expression indicates that EC modulates these pathways, resulting in the inhibition of cell proliferation.	Catechin	133-135	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	68-72
34473289-7	2021	The evaluation of adenosine monophosphate-activated protein kinase (AMPK) and Akt phosphorylation and mTOR expression indicates that EC modulates these pathways, resulting in the inhibition of cell proliferation.	Catechin	133-135	AKT serine/threonine kinase 1	Homo sapiens	78-81
34473289-7	2021	The evaluation of adenosine monophosphate-activated protein kinase (AMPK) and Akt phosphorylation and mTOR expression indicates that EC modulates these pathways, resulting in the inhibition of cell proliferation.	Catechin	133-135	mechanistic target of rapamycin kinase	Homo sapiens	102-106
34771162-1	2021	This work describes an untargeted analytical approach for the screening, identification, and characterization of the trans-epithelial transport of green tea (Camellia sinensis) catechin extracts with in vitro inhibitory effect against the SARS-CoV-2 papain-like protease (PLpro) activity.	Catechin	177-185	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	272-277
34593235-0	2021	Anti-inflammation of epicatechin mediated by TMEM35A and TMPO in bovine mammary epithelial cell line cells and mouse mammary gland.	Catechin	21-32	transmembrane protein 35A	Bos taurus	45-52
34593235-0	2021	Anti-inflammation of epicatechin mediated by TMEM35A and TMPO in bovine mammary epithelial cell line cells and mouse mammary gland.	Catechin	21-32	thymopoietin	Bos taurus	57-61
34593235-5	2021	Furthermore, EC treatment reduced LPS-induced phosphorylation levels of p65 and inhibitor of NF-kappaB, and blocked nuclear translocation of p65 as revealed by western blot and immunofluorescence test in MAC-T cells and the mouse mammary gland.	Catechin	13-15	synaptotagmin 1	Bos taurus	72-75
34593235-5	2021	Furthermore, EC treatment reduced LPS-induced phosphorylation levels of p65 and inhibitor of NF-kappaB, and blocked nuclear translocation of p65 as revealed by western blot and immunofluorescence test in MAC-T cells and the mouse mammary gland.	Catechin	13-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
34593235-5	2021	Furthermore, EC treatment reduced LPS-induced phosphorylation levels of p65 and inhibitor of NF-kappaB, and blocked nuclear translocation of p65 as revealed by western blot and immunofluorescence test in MAC-T cells and the mouse mammary gland.	Catechin	13-15	synaptotagmin 1	Bos taurus	141-144
34593235-6	2021	Epicatechin also attenuated LPS-induced phosphorylation levels of mitogen-activated protein kinase members (i.e., p38, c-Jun N-terminal kinase 1/2 and extracellular regulated protein kinases 1/2).	Catechin	0-11	mitogen-activated protein kinase 14	Mus musculus	114-117
34593235-6	2021	Epicatechin also attenuated LPS-induced phosphorylation levels of mitogen-activated protein kinase members (i.e., p38, c-Jun N-terminal kinase 1/2 and extracellular regulated protein kinases 1/2).	Catechin	0-11	mitogen-activated protein kinase 8	Mus musculus	119-194
34593235-7	2021	Using RNA-seq and tandem mass tag analyses, upregulation of TMEM35A and TMPO proteins was disclosed in MAC-T cells cotreated with LPS and EC.	Catechin	138-140	transmembrane protein 35A	Bos taurus	60-67
34593235-7	2021	Using RNA-seq and tandem mass tag analyses, upregulation of TMEM35A and TMPO proteins was disclosed in MAC-T cells cotreated with LPS and EC.	Catechin	138-140	thymopoietin	Bos taurus	72-76
34959764-1	2021	We previously found increases in uncoupling protein (Ucp)-1 transcription in brown adipose tissue (BAT) of mice following a single oral dose of flavan 3-ol (FL)s, a fraction of catechins and procyanidins.	Catechin	177-186	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	33-59
34805114-6	2021	Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV).	Catechin	27-35	synaptic vesicle glycoprotein 2a	Rattus norvegicus	93-112
34749473-4	2021	Results: (+)-catechin and EGCG could effectively reduce the contents of TG, TC, MDA, ALT and AST, increase the content of SOD in serum of mice with alcoholic fatty liver disease, improve the degree of liver cell edema and reduce the formation of lipid droplets.	Catechin	13-21	glutamic pyruvic transaminase, soluble	Mus musculus	85-88
34749473-4	2021	Results: (+)-catechin and EGCG could effectively reduce the contents of TG, TC, MDA, ALT and AST, increase the content of SOD in serum of mice with alcoholic fatty liver disease, improve the degree of liver cell edema and reduce the formation of lipid droplets.	Catechin	13-21	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	93-96
34771127-6	2021	Correlation analysis indicated that the main galloylated catechins and flavonoid glycosides were highly related to their antioxidant capacity and inhibitory effects on alpha-amylase and alpha-glucosidase.	Catechin	57-66	sucrase-isomaltase	Homo sapiens	186-203
34805114-6	2021	Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV).	Catechin	27-35	synaptic vesicle glycoprotein 2a	Rattus norvegicus	114-118
34737578-12	2021	Mast cell stabilization by benifuuki green tea catechins may reflect the decreased surface expression of FcepsilonRI.	Catechin	47-56	Fc epsilon receptor Ia	Homo sapiens	105-116
34227843-12	2021	Epi treatment was able to significantly block HG induced increases in TGF-beta1, fibronectin, urea, proline, and total collagen protein levels.	Catechin	0-3	transforming growth factor, beta 1	Rattus norvegicus	70-79
34227843-12	2021	Epi treatment was able to significantly block HG induced increases in TGF-beta1, fibronectin, urea, proline, and total collagen protein levels.	Catechin	0-3	fibronectin 1	Rattus norvegicus	81-92
34227843-13	2021	GPER levels were reduced by HG and restored in CFs treated with Epi an effect associated with the activation (i.e., phosphorylation) of c-Src.	Catechin	64-67	G protein-coupled estrogen receptor 1	Rattus norvegicus	0-4
34364457-10	2021	Detection limits of 0.12, 0.28, 0.46, 0.85, and 1.23 mug mL-1 were obtained for gallic acid, quercetin, catechin, kaempferol, and caffeic acid, respectively.	Catechin	104-112	L1 cell adhesion molecule	Mus musculus	57-61
34227843-13	2021	GPER levels were reduced by HG and restored in CFs treated with Epi an effect associated with the activation (i.e., phosphorylation) of c-Src.	Catechin	64-67	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	136-141
34227843-15	2021	Altogether, results demonstrate that CFs cultured in HG acquire a profibrotic phenotype, which is blocked by Epi an effect, likely mediated at least, in part, by GPER effects on the SMAD/TGF-beta1 pathway.	Catechin	109-112	transforming growth factor, beta 1	Rattus norvegicus	187-196
34746186-14	2021	From the overall analyses, we can conclude that Dihydroaltersolanol C, Anthraquinone, Nigbeauvin A, and Catechin are classified as promising candidates for PLpro, thus potentially useful in developing a medicine for COVID-19.	Catechin	104-112	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	156-161
34610737-0	2021	Green Tea Catechins Attenuate Human Primary Pterygium Cell Survival and Migration Via Modulation of ERK p42/p44 and p38 Pathways.	Catechin	10-19	interferon induced protein 44	Homo sapiens	108-111
34610737-0	2021	Green Tea Catechins Attenuate Human Primary Pterygium Cell Survival and Migration Via Modulation of ERK p42/p44 and p38 Pathways.	Catechin	10-19	mitogen-activated protein kinase 14	Homo sapiens	116-119
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Catechin	84-93	sucrase-isomaltase	Homo sapiens	0-17
34403689-0	2021	(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.	Catechin	4-15	NLR family, pyrin domain containing 3	Rattus norvegicus	89-94
34426255-7	2021	The administration of both catechin derivatives from green tea to rats leads to an increase in the activity of ACE and the formation of ROS in the aorta.	Catechin	27-35	angiotensin I converting enzyme	Rattus norvegicus	111-114
34403689-6	2021	Also, EC dramatically inhibits the activation of NLRP3 inflammasome and reduces the CSE-induced pyroptosis, as indicated by decreasing lactate dehydrogenase release and the number of caspase-1-positive cells.	Catechin	6-8	NLR family pyrin domain containing 3	Homo sapiens	49-54
34403689-6	2021	Also, EC dramatically inhibits the activation of NLRP3 inflammasome and reduces the CSE-induced pyroptosis, as indicated by decreasing lactate dehydrogenase release and the number of caspase-1-positive cells.	Catechin	6-8	caspase 1	Rattus norvegicus	183-192
34403689-7	2021	Importantly, Nrf2 knockdown reversed the protective effect of EC on human bronchial epithelial cells, at least partially.	Catechin	62-64	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34403689-9	2021	In conclusion, this study revealed the protective effect of EC on experimental COPD rats and elucidated the mechanism of EC promoting Nrf2 activity, which might provide a novel therapeutic strategy for COPD.	Catechin	60-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
34403689-9	2021	In conclusion, this study revealed the protective effect of EC on experimental COPD rats and elucidated the mechanism of EC promoting Nrf2 activity, which might provide a novel therapeutic strategy for COPD.	Catechin	121-123	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
34388484-0	2021	Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against alpha-Glucosidase.	Catechin	49-58	sucrase-isomaltase	Homo sapiens	103-120
34477517-7	2022	DESCRIPTION: Catechin can regulate Nrf2 and NFkB pathways in ways that impact oxidative stress and inflammation by influencing gene expression.	Catechin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
34579032-1	2021	Green tea extracts and tea catechins have been shown to prevent or alleviate diabetes.	Catechin	27-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	23-26
34477517-8	2022	Other pathways like MAPKs and COMT and receptor tyrosine kinase are also affected by catechin and EGCG that alter their action and barge the cellular activity.	Catechin	85-93	catechol-O-methyltransferase	Homo sapiens	30-34
34477517-8	2022	Other pathways like MAPKs and COMT and receptor tyrosine kinase are also affected by catechin and EGCG that alter their action and barge the cellular activity.	Catechin	85-93	ret proto-oncogene	Homo sapiens	39-63
34477517-11	2022	CONCLUSION: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-kappaB, Nrf-2, TLR4/NF-kappaB, COMT, and MAPKs.	Catechin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	268-277
34477517-11	2022	CONCLUSION: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-kappaB, Nrf-2, TLR4/NF-kappaB, COMT, and MAPKs.	Catechin	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	279-284
34477517-11	2022	CONCLUSION: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-kappaB, Nrf-2, TLR4/NF-kappaB, COMT, and MAPKs.	Catechin	12-20	toll like receptor 4	Homo sapiens	286-290
34477517-11	2022	CONCLUSION: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-kappaB, Nrf-2, TLR4/NF-kappaB, COMT, and MAPKs.	Catechin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	291-300
34477517-11	2022	CONCLUSION: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-kappaB, Nrf-2, TLR4/NF-kappaB, COMT, and MAPKs.	Catechin	12-20	catechol-O-methyltransferase	Homo sapiens	302-306
34573022-3	2021	Cardioprotective effects of catechins in I/R injury were mediated via multiple molecular mechanisms, including inhibition of apoptosis; activation of cardioprotective pathways, such as PI3K/Akt (RISK) pathway; and inhibition of stress-associated pathways, including JNK/p38-MAPK; preserving mitochondrial function; and/or modulating autophagy.	Catechin	28-37	AKT serine/threonine kinase 1	Homo sapiens	190-193
34573022-3	2021	Cardioprotective effects of catechins in I/R injury were mediated via multiple molecular mechanisms, including inhibition of apoptosis; activation of cardioprotective pathways, such as PI3K/Akt (RISK) pathway; and inhibition of stress-associated pathways, including JNK/p38-MAPK; preserving mitochondrial function; and/or modulating autophagy.	Catechin	28-37	mitogen-activated protein kinase 8	Homo sapiens	266-269
34573022-3	2021	Cardioprotective effects of catechins in I/R injury were mediated via multiple molecular mechanisms, including inhibition of apoptosis; activation of cardioprotective pathways, such as PI3K/Akt (RISK) pathway; and inhibition of stress-associated pathways, including JNK/p38-MAPK; preserving mitochondrial function; and/or modulating autophagy.	Catechin	28-37	mitogen-activated protein kinase 14	Homo sapiens	270-278
34314167-0	2021	Catechin Inhibits the Release of Advanced Glycation End Products during Glycated Bovine Serum Albumin Digestion and Corresponding Mechanisms In Vitro.	Catechin	0-8	albumin	Homo sapiens	88-101
34573022-4	2021	Moreover, regulatory roles of several microRNAs, including miR-145, miR-384-5p, miR-30a, miR-92a, as well as lncRNA MIAT, were documented in effects of catechins in cardiac I/R.	Catechin	152-161	microRNA 145	Homo sapiens	59-66
34573022-4	2021	Moreover, regulatory roles of several microRNAs, including miR-145, miR-384-5p, miR-30a, miR-92a, as well as lncRNA MIAT, were documented in effects of catechins in cardiac I/R.	Catechin	152-161	microRNA 384	Homo sapiens	68-75
34573022-4	2021	Moreover, regulatory roles of several microRNAs, including miR-145, miR-384-5p, miR-30a, miR-92a, as well as lncRNA MIAT, were documented in effects of catechins in cardiac I/R.	Catechin	152-161	microRNA 30a	Homo sapiens	80-87
34573022-4	2021	Moreover, regulatory roles of several microRNAs, including miR-145, miR-384-5p, miR-30a, miR-92a, as well as lncRNA MIAT, were documented in effects of catechins in cardiac I/R.	Catechin	152-161	myocardial infarction associated transcript	Homo sapiens	116-120
34646532-10	2021	Moreover, the main phytochemicals in the three tea extracts were determined and quantified via high-performance liquid chromatography, and the most commonly detected ingredients were catechins and caffeine, which could exert the protective effects on AFLD.	Catechin	183-192	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	47-50
34314167-3	2021	This study investigated the inhibitory effect of catechin on AGE release from glycated bovine serum albumin (G-BSA) during gastrointestinal digestion.	Catechin	49-57	renin binding protein	Homo sapiens	61-64
34314167-3	2021	This study investigated the inhibitory effect of catechin on AGE release from glycated bovine serum albumin (G-BSA) during gastrointestinal digestion.	Catechin	49-57	albumin	Homo sapiens	94-107
34314167-4	2021	Catechin inhibited AGE release during gastrointestinal digestion, especially in the gastric digestion stage.	Catechin	0-8	renin binding protein	Homo sapiens	19-22
34147855-9	2021	METHOD: In this study, we performed molecular docking of different catechins with the wild and mutant variants of the spike protein of SARS-CoV-2.	Catechin	67-76	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	118-123
34147855-11	2021	RESULTS: The in-silico studies show that the catechins form favourable interactions with the spike protein and can potentially impair its function.	Catechin	45-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	93-98
34356363-5	2021	A total of 42 compounds were identified, including stilbenes, flavonoids, and phenolic acids, and a complex of (epi)catechin with beta-CD was detected, confirming the interaction between polyphenols and cyclodextrin.	Catechin	116-124	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-137
34171773-5	2021	Curcumin and quercetin showed strong inhibitory effects against all three enzymes, whereas epicatechin, epicatechin gallate (ECg), and epigallocatechin gallate (EGCg) specifically inhibited AADAC.	Catechin	91-102	arylacetamide deacetylase	Homo sapiens	190-195
34115226-0	2021	Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-kappaB and p38 MAPK.	Catechin	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
34115226-0	2021	Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-kappaB and p38 MAPK.	Catechin	25-33	mitogen-activated protein kinase 14	Mus musculus	150-158
34115226-6	2021	The study demonstrated that the inflammatory mediators such as COX, 5-LOX, nitrite, iNOS, and TNF-alpha were significantly inhibited by catechin in a concentration-dependent manner whereas IL-10 production was up-regulated in RAW 264.7 cells.	Catechin	136-144	arachidonate 5-lipoxygenase	Mus musculus	68-73
34115226-6	2021	The study demonstrated that the inflammatory mediators such as COX, 5-LOX, nitrite, iNOS, and TNF-alpha were significantly inhibited by catechin in a concentration-dependent manner whereas IL-10 production was up-regulated in RAW 264.7 cells.	Catechin	136-144	nitric oxide synthase 2, inducible	Mus musculus	84-88
34115226-6	2021	The study demonstrated that the inflammatory mediators such as COX, 5-LOX, nitrite, iNOS, and TNF-alpha were significantly inhibited by catechin in a concentration-dependent manner whereas IL-10 production was up-regulated in RAW 264.7 cells.	Catechin	136-144	tumor necrosis factor	Mus musculus	94-103
34115226-7	2021	Moreover, catechin down-regulated the mRNA level expression of COX-2, iNOS, TNF-alpha, NF-kappaB and p38 MAPK.	Catechin	10-18	cytochrome c oxidase II, mitochondrial	Mus musculus	63-68
34115226-7	2021	Moreover, catechin down-regulated the mRNA level expression of COX-2, iNOS, TNF-alpha, NF-kappaB and p38 MAPK.	Catechin	10-18	nitric oxide synthase 2, inducible	Mus musculus	70-74
34115226-7	2021	Moreover, catechin down-regulated the mRNA level expression of COX-2, iNOS, TNF-alpha, NF-kappaB and p38 MAPK.	Catechin	10-18	tumor necrosis factor	Mus musculus	76-85
34115226-7	2021	Moreover, catechin down-regulated the mRNA level expression of COX-2, iNOS, TNF-alpha, NF-kappaB and p38 MAPK.	Catechin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
34115226-7	2021	Moreover, catechin down-regulated the mRNA level expression of COX-2, iNOS, TNF-alpha, NF-kappaB and p38 MAPK.	Catechin	10-18	mitogen-activated protein kinase 14	Mus musculus	101-109
34333214-9	2021	Catechin has the lowest binding energy with CDK6 and beta-catenin.	Catechin	0-8	cyclin-dependent kinase 6	Mus musculus	44-48
34333214-9	2021	Catechin has the lowest binding energy with CDK6 and beta-catenin.	Catechin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	53-65
34121550-0	2022	Catechin Metabolites along with Curcumin Inhibit Proliferation and Induce Apoptosis in Cervical Cancer Cells by Regulating VEGF Expression In-Vitro.	Catechin	0-8	vascular endothelial growth factor A	Homo sapiens	123-127
34220446-3	2021	We previously reported that oral administration of the flavonoid (-)-epicatechin (EC) reduced Amyloid-beta (Abeta) plaque pathology in APP/PS1 transgenic mice.	Catechin	65-80	presenilin 1	Mus musculus	139-142
34220446-3	2021	We previously reported that oral administration of the flavonoid (-)-epicatechin (EC) reduced Amyloid-beta (Abeta) plaque pathology in APP/PS1 transgenic mice.	Catechin	82-84	presenilin 1	Mus musculus	139-142
34121550-8	2022	Results showed that catechin metabolites along with curcumin reduce the VEGF expression.	Catechin	20-28	vascular endothelial growth factor A	Homo sapiens	72-76
34467690-9	2021	Molecular docking results showed that catechin, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin had strong binding ability with MAPK1, SRC, EGFR, MAPK14 and CASP7.	Catechin	38-46	mitogen activated protein kinase 1	Rattus norvegicus	146-151
34200327-2	2021	Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8+ cytotoxic T lymphocytes-mediated adaptive immunity, and the protective effect on lipopolysaccharide-induced acute lung injury (ALI) in mice.	Catechin	238-247	interleukin 2 receptor subunit alpha	Homo sapiens	251-255
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	CD8a molecule	Homo sapiens	40-43
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	CD69 molecule	Homo sapiens	76-80
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	interleukin 2 receptor subunit alpha	Homo sapiens	82-86
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	killer cell lectin like receptor D1	Homo sapiens	88-92
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	killer cell lectin like receptor C1	Homo sapiens	93-98
34200327-4	2021	Four-week catechins ingestion increased CD8+ T cell percentage, upregulated CD69+/CD25+/CD94-NKG2A/CD8+ T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum.	Catechin	10-19	CD8a molecule	Homo sapiens	99-102
34200327-5	2021	Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism.	Catechin	0-9	AKT serine/threonine kinase 1	Homo sapiens	122-125
34200327-5	2021	Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism.	Catechin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	126-130
34200327-5	2021	Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism.	Catechin	0-9	beclin 1	Homo sapiens	155-163
34200327-5	2021	Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism.	Catechin	0-9	autophagy related 5	Homo sapiens	164-168
34200327-5	2021	Catechins significantly reduced lipopolysaccharide-induced cytokine storm and oxidative stress and ALI by inhibiting PI3K/AKT/mTOR signaling to upregulate Beclin-1/Atg5-Atg12/LC3-II-mediated autophagy mechanism.	Catechin	0-9	autophagy related 12	Homo sapiens	169-174
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	interleukin 2 receptor subunit alpha	Homo sapiens	106-110
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	CD69 molecule	Homo sapiens	111-115
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	killer cell lectin like receptor D1	Homo sapiens	116-120
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	CD8a molecule	Homo sapiens	121-124
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	AKT serine/threonine kinase 1	Homo sapiens	240-243
34200327-7	2021	In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8+ T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection.	Catechin	39-48	mechanistic target of rapamycin kinase	Homo sapiens	244-248
34467690-9	2021	Molecular docking results showed that catechin, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin had strong binding ability with MAPK1, SRC, EGFR, MAPK14 and CASP7.	Catechin	38-46	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	153-156
34467690-9	2021	Molecular docking results showed that catechin, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin had strong binding ability with MAPK1, SRC, EGFR, MAPK14 and CASP7.	Catechin	38-46	epidermal growth factor receptor	Rattus norvegicus	158-162
34467690-9	2021	Molecular docking results showed that catechin, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin had strong binding ability with MAPK1, SRC, EGFR, MAPK14 and CASP7.	Catechin	38-46	mitogen activated protein kinase 14	Rattus norvegicus	164-170
34467690-9	2021	Molecular docking results showed that catechin, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin had strong binding ability with MAPK1, SRC, EGFR, MAPK14 and CASP7.	Catechin	38-46	caspase 7	Rattus norvegicus	175-180
34065602-0	2021	Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil.	Catechin	39-47	lactate dehydrogenase A	Homo sapiens	10-33
34072396-4	2021	This review focuses on resveratrol, (-)-epicatechin, and betaine and summarizes the published data pertaining to their effects on cytochrome c oxidase (COX) which is the terminal enzyme of the mitochondrial electron transport chain and is considered to play an important role in the regulation of mitochondrial respiration.	Catechin	36-51	cytochrome c oxidase subunit 8A	Homo sapiens	152-155
34071530-4	2021	Furthermore, both catechin nanoemulsions and extracts could raise caspase-8, caspase-9 and caspase-3 activities for DU-145 cell apoptosis, arresting the cell cycle at S and G2/M phases.	Catechin	18-26	caspase 8	Homo sapiens	66-75
34071530-4	2021	Furthermore, both catechin nanoemulsions and extracts could raise caspase-8, caspase-9 and caspase-3 activities for DU-145 cell apoptosis, arresting the cell cycle at S and G2/M phases.	Catechin	18-26	caspase 9	Homo sapiens	77-86
34071530-4	2021	Furthermore, both catechin nanoemulsions and extracts could raise caspase-8, caspase-9 and caspase-3 activities for DU-145 cell apoptosis, arresting the cell cycle at S and G2/M phases.	Catechin	18-26	caspase 3	Homo sapiens	91-100
34071530-5	2021	Compared to control, catechin nanoemulsion at 20 mug/mL and paclitaxel at 10 mug/mL were the most effective in reducing tumor volume by 41.3% and 52.5% and tumor weight by 77.5% and 90.6% in mice, respectively, through a decrease in EGF and VEGF levels in serum.	Catechin	21-29	epidermal growth factor	Mus musculus	233-236
34071530-5	2021	Compared to control, catechin nanoemulsion at 20 mug/mL and paclitaxel at 10 mug/mL were the most effective in reducing tumor volume by 41.3% and 52.5% and tumor weight by 77.5% and 90.6% in mice, respectively, through a decrease in EGF and VEGF levels in serum.	Catechin	21-29	vascular endothelial growth factor A	Mus musculus	241-245
34065602-7	2021	Catechin, the simplest compound among them, had the highest inhibitory effect on lactate production and LDHA activity.	Catechin	0-8	lactate dehydrogenase A	Homo sapiens	104-108
34065602-9	2021	Thus, based on these results, we suggest catechin as a candidate for the development of a novel adjuvant drug that reduces chemoresistance to 5FU by restricting LDHA.	Catechin	41-49	lactate dehydrogenase A	Homo sapiens	161-165
35525235-14	2022	Mechanistic studies showed that CD-3 activates PP2A via inhibiting CIP2A and produces tumor growth inhibitory effects via promoting dephosphorylation of oncogenic AKT/mTOR signaling proteins in SCSC cells and xenograft tumors in a PP2A dependent manner.	Catechin	32-36	protein phosphatase 2 phosphatase activator	Homo sapiens	47-51
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Catechin	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Catechin	10-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35217462-2	2022	The purpose of this research was to investigate the non-covalent interaction mechanism between soy protein isolate (SPI) and catechin and its effect on protein conformation.	Catechin	125-133	chromogranin A	Homo sapiens	116-119
35217462-3	2022	We observed that particle size, zeta-potential, and polyphenol bound equivalents of SPI increased significantly after non-covalent modification with catechin.	Catechin	149-157	chromogranin A	Homo sapiens	84-87
35217462-5	2022	Fourier transform infrared spectroscopy (FTIR) indicated that increased catechin concentrations caused SPI to become looser and more disordered as its alpha-helix and beta-sheet transformed into beta-turn and random coil.	Catechin	72-80	chromogranin A	Homo sapiens	103-106
35217462-7	2022	Thermodynamic analysis and molecular docking results showed that the main forces present between SPI and catechin were hydrophobic interactions and hydrogen bonds.	Catechin	105-113	chromogranin A	Homo sapiens	97-100
35568144-0	2022	Structurally related (-)-epicatechin metabolites and gut microbiota derived metabolites exert genomic modifications via VEGF signaling pathways in brain microvascular endothelial cells under lipotoxic conditions: Integrated multi-omic study.	Catechin	25-36	vascular endothelial growth factor A	Homo sapiens	120-124
35525235-14	2022	Mechanistic studies showed that CD-3 activates PP2A via inhibiting CIP2A and produces tumor growth inhibitory effects via promoting dephosphorylation of oncogenic AKT/mTOR signaling proteins in SCSC cells and xenograft tumors in a PP2A dependent manner.	Catechin	32-36	cellular inhibitor of PP2A	Homo sapiens	67-72
35525235-14	2022	Mechanistic studies showed that CD-3 activates PP2A via inhibiting CIP2A and produces tumor growth inhibitory effects via promoting dephosphorylation of oncogenic AKT/mTOR signaling proteins in SCSC cells and xenograft tumors in a PP2A dependent manner.	Catechin	32-36	AKT serine/threonine kinase 1	Homo sapiens	163-166
35525235-14	2022	Mechanistic studies showed that CD-3 activates PP2A via inhibiting CIP2A and produces tumor growth inhibitory effects via promoting dephosphorylation of oncogenic AKT/mTOR signaling proteins in SCSC cells and xenograft tumors in a PP2A dependent manner.	Catechin	32-36	mechanistic target of rapamycin kinase	Homo sapiens	167-171
35525235-14	2022	Mechanistic studies showed that CD-3 activates PP2A via inhibiting CIP2A and produces tumor growth inhibitory effects via promoting dephosphorylation of oncogenic AKT/mTOR signaling proteins in SCSC cells and xenograft tumors in a PP2A dependent manner.	Catechin	32-36	protein phosphatase 2 phosphatase activator	Homo sapiens	231-235
35585729-12	2022	The predictive result of toxicity demonstrated that catechin and nakinadine B doesn"t induce cytotoxicity, immunotoxicity, carcinogenicity, mutagenicity, hepatotoxicity and were at medium risk for hERG inhibition.	Catechin	52-60	ETS transcription factor ERG	Homo sapiens	197-201
35587203-7	2022	To probe the role of small-molecule structural features that impede IAPP aggregation, molecular dynamics simulations were performed to observe trimer formation on a model fragment of IAPP(20-29) in the presence of morin, quercetin, dihydroquercetin, epicatechin, and myricetin.	Catechin	250-261	islet amyloid polypeptide	Homo sapiens	183-187
35000557-7	2022	Anti-inflammatory and anti-apoptotic activities of catechin and EGCG were investigated by indirect immunocytochemistry using anti-TNF-alpha, anti-IL-1beta and anti-caspase-3.	Catechin	51-59	interleukin 1 alpha	Homo sapiens	146-154
35000557-11	2022	Caspase-3 immunoreactivity was significantly reduced in SK-N-AS and PD model cells after EGCG administration, while it was decreased only in PD model cells after catechin administration.	Catechin	162-170	caspase 3	Homo sapiens	0-9
35000557-12	2022	IL-1beta staining intensity weakened after catechin administration in PD model cells, after EGCG administration in SK-N-AS cells.	Catechin	43-51	interleukin 1 alpha	Homo sapiens	0-8
35631180-6	2022	We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome.	Catechin	28-36	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	48-54
35609849-0	2022	(-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage.	Catechin	0-17	CD1 antigen complex	Mus musculus	62-65
35502961-5	2022	EC and DHBA also increased the tyrosine phosphorylated and total insulin receptor (IR) levels, and activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in cardiac H9c2 cells.	Catechin	0-2	insulin receptor	Rattus norvegicus	65-81
35502961-5	2022	EC and DHBA also increased the tyrosine phosphorylated and total insulin receptor (IR) levels, and activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in cardiac H9c2 cells.	Catechin	0-2	insulin receptor	Rattus norvegicus	83-85
35502961-5	2022	EC and DHBA also increased the tyrosine phosphorylated and total insulin receptor (IR) levels, and activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in cardiac H9c2 cells.	Catechin	0-2	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	113-142
35502961-5	2022	EC and DHBA also increased the tyrosine phosphorylated and total insulin receptor (IR) levels, and activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in cardiac H9c2 cells.	Catechin	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	168-171
35502961-6	2022	Interestingly, EC and DHBA did not modify glucose transporters (SGLT-1 and GLUT-1) levels, and increased GLUT-4 values.	Catechin	15-17	solute carrier family 2 member 4	Rattus norvegicus	105-111
35502961-9	2022	Taken together, EC and DHBA modulate glucose uptake and lipid accumulation via AKT and AMPK, and reinforce the insulin signalling by activating key proteins of this pathway in H9c2 cells.	Catechin	16-18	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
35502961-9	2022	Taken together, EC and DHBA modulate glucose uptake and lipid accumulation via AKT and AMPK, and reinforce the insulin signalling by activating key proteins of this pathway in H9c2 cells.	Catechin	16-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	87-91
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	13-21	proprotein convertase subtilisin/kexin type 9	Homo sapiens	43-48
35487926-5	2022	Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol.	Catechin	103-111	interleukin 1 alpha	Mus musculus	28-36
35487926-5	2022	Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol.	Catechin	103-111	acid phosphatase 5, tartrate resistant	Mus musculus	51-55
35462936-0	2022	(-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-kappaB Signaling Pathway.	Catechin	0-15	NLR family pyrin domain containing 3	Homo sapiens	94-99
35462936-0	2022	(-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-kappaB Signaling Pathway.	Catechin	0-15	nuclear factor kappa B subunit 1	Homo sapiens	121-130
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	interleukin 1 alpha	Homo sapiens	54-62
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	interleukin 18	Homo sapiens	64-69
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	interleukin 6	Homo sapiens	71-75
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	tumor necrosis factor	Homo sapiens	81-90
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	NLR family pyrin domain containing 3	Homo sapiens	106-111
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	nuclear factor kappa B subunit 1	Homo sapiens	129-138
35462936-8	2022	Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis.	Catechin	41-43	NLR family pyrin domain containing 3	Homo sapiens	119-124
35462936-8	2022	Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis.	Catechin	41-43	nuclear factor kappa B subunit 1	Homo sapiens	146-155
35462936-8	2022	Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis.	Catechin	217-219	NLR family pyrin domain containing 3	Homo sapiens	119-124
35462936-8	2022	Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis.	Catechin	217-219	nuclear factor kappa B subunit 1	Homo sapiens	146-155
35344129-7	2022	With the peculiar behaviour and significant interactions of the functional residues of target proteins with selected ligands along with the best absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, it is concluded that catechin could be the best MAO-A inhibitor at a binding energy of -8.85 kcal/mol, and two hydrogen bonds were generated with Cys406 (A) and Gly443 (A) residues of the active binding site of MAO-A enzyme.	Catechin	248-256	monoamine oxidase A	Mus musculus	275-280
35344129-7	2022	With the peculiar behaviour and significant interactions of the functional residues of target proteins with selected ligands along with the best absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, it is concluded that catechin could be the best MAO-A inhibitor at a binding energy of -8.85 kcal/mol, and two hydrogen bonds were generated with Cys406 (A) and Gly443 (A) residues of the active binding site of MAO-A enzyme.	Catechin	248-256	monoamine oxidase A	Mus musculus	438-443
35344129-9	2022	Therefore, it is highly recommended to test the selected lead-like compound catechin in the laboratory with biological system analysis to confirm its activity as MAO-A and MAO-B inhibitors so it can be declared as one of the novel therapeutic options with anti-depressant activity.	Catechin	76-84	monoamine oxidase A	Mus musculus	162-167
35238254-6	2022	In this context, phenolic compounds (catechins, quercetin, and chrysin) are the most extensively BCs studied and encapsulated in albumin-based nanocarriers.	Catechin	37-46	albumin	Homo sapiens	129-136
35205982-6	2022	Among them, (-)-epigallocatechin-3-gallate (EGCG), one of the main monomers of catechins, may be activated as nuclear factor erythroid 2 p45-related factor 2 (Nrf2).	Catechin	79-88	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
35056753-4	2022	Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 muM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene.	Catechin	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
35056753-4	2022	Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 muM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene.	Catechin	25-36	nitric oxide synthase 2	Homo sapiens	224-228
35134507-8	2022	In vitro, we demonstrated GT catechins act to reduce hepatic steatosis in a PPARalpha-dependent manner, and especially epigallocatechin and epicatechin can indirectly activate PPARalpha, although it seems they are not direct ligands.	Catechin	29-38	peroxisome proliferator activated receptor alpha	Mus musculus	76-85
35134507-8	2022	In vitro, we demonstrated GT catechins act to reduce hepatic steatosis in a PPARalpha-dependent manner, and especially epigallocatechin and epicatechin can indirectly activate PPARalpha, although it seems they are not direct ligands.	Catechin	140-151	peroxisome proliferator activated receptor alpha	Mus musculus	176-185
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Catechin	27-35	interleukin 1 alpha	Rattus norvegicus	139-147
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Catechin	27-35	tumor necrosis factor	Rattus norvegicus	149-158
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Catechin	27-35	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	185-188
35337893-7	2022	While administration of catechin produced a more pronounced attenuating effect on IL-1beta, TNF-alpha, and p53 genes, the attenuating effect of quercetin (20mg/kg) was more pronounced on NF-kappaB and IkappaKB gene expressions when compared to the group administered with rotenone only.	Catechin	24-32	interleukin 1 alpha	Rattus norvegicus	82-90
35337893-7	2022	While administration of catechin produced a more pronounced attenuating effect on IL-1beta, TNF-alpha, and p53 genes, the attenuating effect of quercetin (20mg/kg) was more pronounced on NF-kappaB and IkappaKB gene expressions when compared to the group administered with rotenone only.	Catechin	24-32	tumor necrosis factor	Rattus norvegicus	92-101
35337893-7	2022	While administration of catechin produced a more pronounced attenuating effect on IL-1beta, TNF-alpha, and p53 genes, the attenuating effect of quercetin (20mg/kg) was more pronounced on NF-kappaB and IkappaKB gene expressions when compared to the group administered with rotenone only.	Catechin	24-32	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	107-110
35345470-7	2022	TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones.	Catechin	151-160	taste 2 receptor member 39	Homo sapiens	0-7
35268072-4	2022	(-)-Epicatechin, a botanical compound known for its vasodilatory, eNOS, and mitochondrial-stimulating properties, is a potential therapy in those with CVD.	Catechin	0-15	nitric oxide synthase 3	Rattus norvegicus	66-70
35268072-5	2022	We hypothesized that (-)-epicatechin would support eNOS activity and mitochondrial respiration, leading to improved vasoreactivity in a thermoneutral-derived rat model of vascular dysfunction.	Catechin	25-36	nitric oxide synthase 3	Rattus norvegicus	51-55
35268072-9	2022	AMPK and CaMKIIalpha and beta expression were lessened with (-)-epicatechin treatment in those housed at thermoneutrality (p < 0.05).	Catechin	64-75	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	0-4
35249660-7	2022	In addition, at transcriptional levels, a high concentration of catechin exposure reduced the expression genes of Mn-SOD, Cat, gst, and GPX induced by CPF in larval zebrafish.	Catechin	64-72	superoxide dismutase 2, mitochondrial	Danio rerio	114-120
35249660-7	2022	In addition, at transcriptional levels, a high concentration of catechin exposure reduced the expression genes of Mn-SOD, Cat, gst, and GPX induced by CPF in larval zebrafish.	Catechin	64-72	catalase	Danio rerio	122-125
35249660-9	2022	Catechin also could reduce the transcription of p53 and bax, which are tightly related to the apoptosis induced by CPF in zebrafish larvae.	Catechin	0-8	tumor protein p53	Danio rerio	48-51
35249660-9	2022	Catechin also could reduce the transcription of p53 and bax, which are tightly related to the apoptosis induced by CPF in zebrafish larvae.	Catechin	0-8	BCL2 associated X, apoptosis regulator a	Danio rerio	56-59
35227055-5	2022	Results: Theaflavin and catechin, the natural components of black tea and green tea, out of 10 shortlisted compounds have shown excellent performance in our docking studies with the minimum binding energy of -11.8 kcal/mol and -9.2 kcal/mol respectively, against a novel nsp10-nsp16 complex of SARS-CoV-2 that indicates their potential for inhibitory molecular interactions against the virus to assist rapid drug designing from natural products.	Catechin	24-32	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	271-276
35164310-6	2022	Among the flavan-3-ols recognized as substrates, (+)-gallocatechin was only transformed into delphinidin by VvANS, whereas (+)-catechin was transformed into three products, including two major products that were an ascorbate-cyanidin adduct and a dimer of oxidized catechin, and a minor product that was cyanidin.	Catechin	265-273	leucoanthocyanidin dioxygenase	Vitis vinifera	108-113
35078974-4	2022	Here, we found that the phenolic compound (-)-epicatechin, isolated from Theobroma cacao, effectively inhibited FGFR3"s downstream signaling pathways.	Catechin	42-57	fibroblast growth factor receptor 3	Mus musculus	112-117
35078974-8	2022	In vivo, we confirmed that daily subcutaneous injections of (-)-epicatechin to Fgfr3Y367C/+ mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.	Catechin	60-75	fibroblast growth factor receptor 3	Mus musculus	79-84
35069974-14	2022	Finally, EPI transiently enhanced ERK1/2 phosphorylation (2.9 and 3.2-fold over 15 min and 1 h vs. 0 h, respectively; P = 0.035 and P = 0.011).	Catechin	9-12	mitogen-activated protein kinase 3	Homo sapiens	34-40
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	13-21	low density lipoprotein receptor	Homo sapiens	73-77
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	13-21	proprotein convertase subtilisin/kexin type 9	Homo sapiens	184-189
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	122-130	proprotein convertase subtilisin/kexin type 9	Homo sapiens	43-48
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	122-130	low density lipoprotein receptor	Homo sapiens	73-77
34653909-5	2022	However, (+)-catechin was found to inhibit PCSK9 expression and increase LDLR expression, suggesting the potential of (+)-catechin to lower cholesterol level via the downregulation of PCSK9 expression.	Catechin	122-130	proprotein convertase subtilisin/kexin type 9	Homo sapiens	184-189