PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	spectaline	69-83	mitogen-activated protein kinase 1	Homo sapiens	190-193
30828001-3	2019	Following our previous studies regarding the synthesis of (+)-spectaline, herein we report the first convergent synthesis of (-)-iso-6-spectaline using a cross-metathesis under thermal conditions where the cis-2,6-disubstituted piperidin-3-ol scaffold is condensed with a long alkyl chain containing a terminal olefin.	spectaline	58-72	suppressor of cytokine signaling 2	Homo sapiens	206-211
30828001-5	2019	It was confirmed that (+)-spectaline, an epimer of (-)-iso-6-spectaline, was selectively synthesized by the cross-metathesis reaction under less intense thermal conditions starting from the same cis-2,6-disubstituted piperidin-3-ol derivative.	spectaline	22-36	suppressor of cytokine signaling 2	Homo sapiens	195-200
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	spectaline	69-83	cyclin D1	Homo sapiens	229-238
18096154-0	2008	CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline.	spectaline	100-114	butyrylcholinesterase	Rattus norvegicus	29-43
18096154-1	2008	LASSBio-767 [(-)-3-O-acetyl-spectaline] and LASSBio-822 [(-)-3-O-tert-Boc-spectaline] were recently described as cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline, obtained from the flowers of Senna spectabilis (Fabaceae).	spectaline	184-198	butyrylcholinesterase	Rattus norvegicus	113-127
18096154-13	2008	Thus, the (-)-spectaline derivatives are potent cholinergic agents in vivo, with a unique profile combining noncompetitive cholinesterase inhibition and CNS selectivity, with few peripheral side effects.	spectaline	10-24	butyrylcholinesterase	Rattus norvegicus	123-137