PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23404505-1	2013	VEGF-D is an angiogenic and lymphangiogenic glycoprotein that can be proteolytically processed generating various forms differing in subunit composition due to the presence or absence of N- and C-terminal propeptides.	propeptides	205-216	vascular endothelial growth factor D	Mus musculus	0-6
23585398-3	2013	Our laboratory previously demonstrated that protein domains located within precursor proteins, propeptides, encode histidine-driven pH sensors to regulate organelle-specific activation of the eukaryotic proteases furin and proprotein convertase-1/3.	propeptides	95-106	furin, paired basic amino acid cleaving enzyme	Homo sapiens	213-218
23404505-7	2013	The mature form of VEGF-D, lacking both propeptides, can also promote formation of these receptor heterodimers.	propeptides	40-51	vascular endothelial growth factor D	Mus musculus	19-25
23404505-10	2013	The findings reported here show that the propeptides profoundly influence molecular interactions of VEGF-D with VEGF receptors, co-receptors, and heparin, and its effects on tumor biology.	propeptides	41-52	vascular endothelial growth factor D	Mus musculus	100-106
23344023-5	2012	The dimeric VEGF-C undergoes a series of proteolytic cleavage steps that increase the protein binding affinity to VEGFR-3; however, only complete processing, removing both the N- and C-terminal propeptides, yields mature VEGF-C that can bind to VEGFR-2.	propeptides	194-205	vascular endothelial growth factor C	Homo sapiens	12-18
22248481-7	2012	Examination of the osteoblast phenotype revealed that markers of bone formation, i.e. procollagen type I N-terminal propeptides, and osteoblast lineage markers as well as the TRAP 1B mRNA transcript are increased in TRAP-overexpressing mice.	propeptides	116-127	acid phosphatase 5, tartrate resistant	Mus musculus	216-220
22743102-0	2012	Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.	propeptides	0-11	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
22743102-0	2012	Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.	propeptides	0-11	proprotein convertase subtilisin/kexin type 1	Homo sapiens	95-120
22743102-10	2012	Swapping propeptides between furin and PC1 transfers pH-dependent protease activation in a propeptide-dictated manner in vitro and in cells.	propeptides	9-20	furin, paired basic amino acid cleaving enzyme	Homo sapiens	29-34
22743102-10	2012	Swapping propeptides between furin and PC1 transfers pH-dependent protease activation in a propeptide-dictated manner in vitro and in cells.	propeptides	9-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	39-42
22123825-6	2012	Ape1 dodecamerization may cluster propeptides into trimeric structures, with sufficient affinity to form propeptide hexamers by binding to other dodecamers, causing aggregation.	propeptides	34-45	metalloaminopeptidase APE1	Saccharomyces cerevisiae S288C	0-4
21343449-0	2011	In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.	propeptides	46-57	elastase, neutrophil expressed	Homo sapiens	71-90
23251442-2	2012	Transgenic over-expression of IGF-1 propeptides facilitates protection and repair in a broad range of tissues, although transgenic mice over-expressing IGF-1 propeptides display little or no increase in IGF-1 serum levels, even with high levels of transgene expression.	propeptides	36-47	insulin-like growth factor 1	Mus musculus	30-35
23251442-2	2012	Transgenic over-expression of IGF-1 propeptides facilitates protection and repair in a broad range of tissues, although transgenic mice over-expressing IGF-1 propeptides display little or no increase in IGF-1 serum levels, even with high levels of transgene expression.	propeptides	158-169	insulin-like growth factor 1	Mus musculus	152-157
23251442-2	2012	Transgenic over-expression of IGF-1 propeptides facilitates protection and repair in a broad range of tissues, although transgenic mice over-expressing IGF-1 propeptides display little or no increase in IGF-1 serum levels, even with high levels of transgene expression.	propeptides	158-169	insulin-like growth factor 1	Mus musculus	152-157
23251442-3	2012	IGF-1 propeptides are encoded by multiple alternatively spliced transcripts including C-terminal extension (E) peptides, which are highly positively charged.	propeptides	6-17	insulin-like growth factor 1	Mus musculus	0-5
21750050-4	2011	Propeptides mediate the synthesis and secretion of all TGFbeta ligands and, for some family members (e.g. TGFbeta1), bind the mature growth factor with high enough affinity to confer latency.	propeptides	0-11	transforming growth factor, beta 1	Mus musculus	55-62
21750050-4	2011	Propeptides mediate the synthesis and secretion of all TGFbeta ligands and, for some family members (e.g. TGFbeta1), bind the mature growth factor with high enough affinity to confer latency.	propeptides	0-11	transforming growth factor, beta 1	Mus musculus	106-114
21515745-3	2011	The propeptides can be cleaved from VEGF-D, enhancing affinity for VEGFR-2 and VEGFR-3 in vitro; however, the importance of this processing in cancer is unclear.	propeptides	4-15	vascular endothelial growth factor D	Homo sapiens	36-42
21515745-3	2011	The propeptides can be cleaved from VEGF-D, enhancing affinity for VEGFR-2 and VEGFR-3 in vitro; however, the importance of this processing in cancer is unclear.	propeptides	4-15	kinase insert domain receptor	Homo sapiens	67-74
21515745-3	2011	The propeptides can be cleaved from VEGF-D, enhancing affinity for VEGFR-2 and VEGFR-3 in vitro; however, the importance of this processing in cancer is unclear.	propeptides	4-15	fms related receptor tyrosine kinase 4	Homo sapiens	79-86
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	97-108	fms related receptor tyrosine kinase 4	Homo sapiens	0-7
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	97-108	vascular endothelial growth factor C	Homo sapiens	16-22
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	97-108	vascular endothelial growth factor D	Homo sapiens	27-33
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	185-196	fms related receptor tyrosine kinase 4	Homo sapiens	0-7
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	185-196	vascular endothelial growth factor C	Homo sapiens	16-22
21148085-2	2011	VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding on proteolytic removal of the propeptides.	propeptides	185-196	vascular endothelial growth factor D	Homo sapiens	27-33
20535473-0	2010	Soybean peroxidase propeptides are functional signal peptides and increase the yield of a foreign protein.	propeptides	19-30	peroxidase	Glycine max	8-18
21353880-6	2011	Propeptides may increase the half-life of inhibin A and B in circulation, but they are readily displaced in the presence of the high-affinity receptors, betaglycan, and ActRII.	propeptides	0-11	transforming growth factor beta receptor 3	Homo sapiens	153-163
21353880-6	2011	Propeptides may increase the half-life of inhibin A and B in circulation, but they are readily displaced in the presence of the high-affinity receptors, betaglycan, and ActRII.	propeptides	0-11	activin A receptor type 2A	Homo sapiens	169-175
20729553-4	2010	PCPE-1 consists of two CUB domains that bind to the procollagen C-propeptides and are required for PCP enhancing activity, and one NTR domain that binds heparin.	propeptides	66-77	procollagen C-endopeptidase enhancer protein	Mus musculus	0-6
20026052-5	2010	Classic BMP1, the full-length gene transcript mTLD (BMP1-3), and BMP1-5 (isoform lacking the CUB3 domain thought to be important for efficient type I collagen C-propeptidase activity) all removed the analogous propeptides from both recombinant human prodecorin and murine probiglycan.	propeptides	210-221	bone morphogenetic protein 15	Homo sapiens	65-71
20534510-5	2010	The PDGF-B:PDGFRbeta interface is predominantly hydrophobic, and PDGFRs and the PDGF propeptides occupy overlapping positions on mature PDGFs, rationalizing the need of propeptides by PDGFs to cover functionally important hydrophobic surfaces during secretion.	propeptides	169-180	platelet derived growth factor subunit B	Homo sapiens	4-10
20026052-8	2010	Since the third member of the Class I small leucine-rich proteooglycan (SLRP) superfamily, asporin, also contains a similar cleavage motif at the appropriate location, we propose that the removal of these propeptides by members of the BMP1 family is an additional characteristic of Class I SLRP.	propeptides	205-216	bone morphogenetic protein 1	Homo sapiens	235-239
19743472-4	2010	In vitro A204 cells reporter assays showed that both wild-type and the mutated propeptides depressed myostatin activity.	propeptides	79-90	myostatin	Mus musculus	101-110
19743472-5	2010	The recombinant propeptides at four-fold myostatin concentration can effectively block myostatin function during co-incubation with A204 cells.	propeptides	16-27	myostatin	Mus musculus	41-50
19743472-5	2010	The recombinant propeptides at four-fold myostatin concentration can effectively block myostatin function during co-incubation with A204 cells.	propeptides	16-27	myostatin	Mus musculus	87-96
19100723-1	2009	Opiate-induced alterations in the gene expression of the opioid propeptides prodynorphin (PDYN) and proenkephalin (PENK) in the brain have previously been described.	propeptides	64-75	prodynorphin	Rattus norvegicus	76-88
19443835-7	2009	Furthermore, receptor activation and arteriogenic activity were increased by an alanine substitution mutant of human VEGF-C (C137A) having an increased dimer stability and by a chimeric CAC growth factor that contained the VEGF receptor-binding domain flanked by VEGF-C propeptides, but only the latter promoted significantly more blood vessel perfusion when compared to the other growth factors studied.	propeptides	270-281	vascular endothelial growth factor C	Homo sapiens	117-123
19443835-7	2009	Furthermore, receptor activation and arteriogenic activity were increased by an alanine substitution mutant of human VEGF-C (C137A) having an increased dimer stability and by a chimeric CAC growth factor that contained the VEGF receptor-binding domain flanked by VEGF-C propeptides, but only the latter promoted significantly more blood vessel perfusion when compared to the other growth factors studied.	propeptides	270-281	vascular endothelial growth factor A	Mus musculus	117-121
19100723-1	2009	Opiate-induced alterations in the gene expression of the opioid propeptides prodynorphin (PDYN) and proenkephalin (PENK) in the brain have previously been described.	propeptides	64-75	prodynorphin	Rattus norvegicus	90-94
18790733-12	2008	Our results suggest that the propeptides stabilize the tertiary structure of the "mature" Spatzle cystine knot.	propeptides	29-40	spatzle	Drosophila melanogaster	90-97
18813864-2	2008	At present 4 propeptides designated as Cbln1, Cbln2, Cbln3 and Cbln4 are recognized.	propeptides	13-24	cerebellin 1 precursor	Rattus norvegicus	39-44
18813864-2	2008	At present 4 propeptides designated as Cbln1, Cbln2, Cbln3 and Cbln4 are recognized.	propeptides	13-24	cerebellin 2 precursor	Rattus norvegicus	46-51
18813864-2	2008	At present 4 propeptides designated as Cbln1, Cbln2, Cbln3 and Cbln4 are recognized.	propeptides	13-24	cerebellin 3 precursor	Rattus norvegicus	53-58
18813864-2	2008	At present 4 propeptides designated as Cbln1, Cbln2, Cbln3 and Cbln4 are recognized.	propeptides	13-24	cerebellin 4 precursor	Rattus norvegicus	63-68
18621057-2	2008	BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently associated with two propeptides.	propeptides	102-113	bone morphogenetic protein 7	Homo sapiens	0-5
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	propeptides	286-297	stabilin 2	Homo sapiens	46-50
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	propeptides	286-297	stabilin 2	Homo sapiens	53-63
18625069-2	2008	In the yeast Saccharomyces cerevisiae the Kex2 protein is biochemically well investigated, however, with the exception of a few well known proteins such as the alpha-pheromone precursors, killer toxin precursors and aspartic proteinase propeptides, very few substrates are known.	propeptides	236-247	kexin KEX2	Saccharomyces cerevisiae S288C	42-46
18339631-7	2008	Binding studies revealed that the N-terminal end of fibrillin-1 serves as a universal high affinity docking site for the propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not GDF-8, and located the BMP/GDF binding site within the N-terminal domain in fibrillin-1.	propeptides	121-132	fibrillin 1	Homo sapiens	52-63
18650933-5	2008	Starting from beta2, incorporation of beta-subunits occurs in an orderly manner dependent on the propeptides of beta2 and beta5, and the C-terminal tail of beta2.	propeptides	97-108	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	112-117
18650933-5	2008	Starting from beta2, incorporation of beta-subunits occurs in an orderly manner dependent on the propeptides of beta2 and beta5, and the C-terminal tail of beta2.	propeptides	97-108	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	112-117
18339631-7	2008	Binding studies revealed that the N-terminal end of fibrillin-1 serves as a universal high affinity docking site for the propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not GDF-8, and located the BMP/GDF binding site within the N-terminal domain in fibrillin-1.	propeptides	121-132	bone morphogenetic protein 2	Homo sapiens	136-158
18339631-7	2008	Binding studies revealed that the N-terminal end of fibrillin-1 serves as a universal high affinity docking site for the propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not GDF-8, and located the BMP/GDF binding site within the N-terminal domain in fibrillin-1.	propeptides	121-132	growth differentiation factor 5	Homo sapiens	163-168
18339631-7	2008	Binding studies revealed that the N-terminal end of fibrillin-1 serves as a universal high affinity docking site for the propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not GDF-8, and located the BMP/GDF binding site within the N-terminal domain in fibrillin-1.	propeptides	121-132	fibrillin 1	Homo sapiens	254-265
14766790-2	2004	It is generally accepted that MMPs are secreted in a latent form (proMMP) and are activated only upon removal of their inhibitory propeptides.	propeptides	130-141	matrix metallopeptidase 2	Homo sapiens	30-34
17475939-2	2007	RESEARCH DESIGN AND METHODS: We tested the impact on insulin and insulin propeptides of taking 13 cord blood samples in heparin and EDTA and then centrifuging and separating plasma after 1, 2, 24, or 48 h at room temperature (heparin) or 4 degrees C (EDTA).	propeptides	73-84	insulin	Homo sapiens	65-72
17475939-4	2007	RESULTS: Cord insulin concentrations significantly decreased (74% those at baseline by 24 h; P = 0.01) in the samples taken in heparin and stored at room temperature, but those taken on EDTA and refrigerated remained stable for up to 48 h. Insulin propeptides were stable in both.	propeptides	248-259	insulin	Homo sapiens	14-21
17475939-5	2007	Cord plasma insulin and insulin propeptides measured in EDTA were related to all measures of birth size and maternal glycemia and BMI (r > 0.11; P < 0.03 for all) and were higher in those delivered via caesarean section.	propeptides	32-43	insulin	Homo sapiens	24-31
17478734-2	2007	To study the functions of the VEGF-C propeptides, we engineered a chimeric growth factor protein, VEGF-CAC, composed of the amino- and carboxy-terminal propeptides of VEGF-C fused to the receptor-activating core domain of VEGF.	propeptides	37-48	vascular endothelial growth factor A	Homo sapiens	30-34
17242158-8	2007	The PCs furin and PC5 promote cleavage of both propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only.	propeptides	47-58	proprotein convertase subtilisin/kexin type 5	Homo sapiens	18-21
17302431-3	2007	Here, we describe a novel mechanism for the regulation of the activity of Hex based on the association of their catalytic subunits with the large N-terminal propeptides in vivo.	propeptides	157-168	hematopoietically expressed homeobox	Homo sapiens	74-77
16686598-6	2006	Subsequent analysis with an antibody specifically recognising the propeptide of MT1-MMP revealed that the propeptides of the MT1-MT4-MMP chimaeras failed to undergo proper processing.	propeptides	106-117	matrix metallopeptidase 14	Homo sapiens	80-87
16686598-6	2006	Subsequent analysis with an antibody specifically recognising the propeptide of MT1-MMP revealed that the propeptides of the MT1-MT4-MMP chimaeras failed to undergo proper processing.	propeptides	106-117	metallothionein 1I, pseudogene	Homo sapiens	80-83
16686598-6	2006	Subsequent analysis with an antibody specifically recognising the propeptide of MT1-MMP revealed that the propeptides of the MT1-MT4-MMP chimaeras failed to undergo proper processing.	propeptides	106-117	matrix metallopeptidase 17	Homo sapiens	129-136
16801943-6	2006	Consistent with our proposal, concentrations of insulin and/or its propeptides are higher at birth in female populations and they are intrinsically more insulin resistant throughout life, with attendant impact on their metabolism, and the regressions describing the relationship between insulin resistance and adiposity in female and male subjects have similar gradients, but different constants.	propeptides	67-78	insulin	Homo sapiens	48-55
16801943-6	2006	Consistent with our proposal, concentrations of insulin and/or its propeptides are higher at birth in female populations and they are intrinsically more insulin resistant throughout life, with attendant impact on their metabolism, and the regressions describing the relationship between insulin resistance and adiposity in female and male subjects have similar gradients, but different constants.	propeptides	67-78	insulin	Homo sapiens	153-160
16801943-6	2006	Consistent with our proposal, concentrations of insulin and/or its propeptides are higher at birth in female populations and they are intrinsically more insulin resistant throughout life, with attendant impact on their metabolism, and the regressions describing the relationship between insulin resistance and adiposity in female and male subjects have similar gradients, but different constants.	propeptides	67-78	insulin	Homo sapiens	153-160
16412997-2	2006	Although regulation of the gene expression of the opioid propeptides proenkephalin (PENK) and prodynorphin (PDYN) by psychostimulants has previously been described, little attention has been paid to dissociating effects of pharmacological actions of the drugs from those produced by motivational processes driving active drug intake in self-administration paradigms.	propeptides	57-68	proenkephalin	Rattus norvegicus	69-82
16412997-2	2006	Although regulation of the gene expression of the opioid propeptides proenkephalin (PENK) and prodynorphin (PDYN) by psychostimulants has previously been described, little attention has been paid to dissociating effects of pharmacological actions of the drugs from those produced by motivational processes driving active drug intake in self-administration paradigms.	propeptides	57-68	proenkephalin	Rattus norvegicus	84-88
16751694-3	2006	Propeptides of type I procollagen are generated during the process of collagen formation in bone matrix.	propeptides	0-11	collagen type I alpha 2 chain	Homo sapiens	15-33
16102054-3	2005	Most propeptides bind tightly to GGCX and all of the Glu residues that will be modified are modified during one binding event.	propeptides	5-16	gamma-glutamyl carboxylase	Homo sapiens	33-37
15572036-7	2005	Recombinant stabilin-2, but not recombinant stabilin-1, bound HA and the scavenger receptor ligands AGE-modified BSA, formaldehyde-treated BSA, and collagen N-terminal propeptides.	propeptides	168-179	stabilin 2	Homo sapiens	12-22
15567420-1	2005	Transforming growth factor beta (TGF-beta) is secreted primarily as a latent complex consisting of the TGF-beta homodimer, the TGF-beta propeptides (called the latency-associated protein or LAP) and the latent TGF-beta binding protein (LTBP).	propeptides	136-147	transforming growth factor beta 1	Homo sapiens	0-31
15567420-1	2005	Transforming growth factor beta (TGF-beta) is secreted primarily as a latent complex consisting of the TGF-beta homodimer, the TGF-beta propeptides (called the latency-associated protein or LAP) and the latent TGF-beta binding protein (LTBP).	propeptides	136-147	transforming growth factor beta 1	Homo sapiens	33-41
15567420-1	2005	Transforming growth factor beta (TGF-beta) is secreted primarily as a latent complex consisting of the TGF-beta homodimer, the TGF-beta propeptides (called the latency-associated protein or LAP) and the latent TGF-beta binding protein (LTBP).	propeptides	136-147	TNF receptor associated factor 3	Homo sapiens	190-193
15567420-13	2005	These studies identify surface residues that contribute to the interactions of 8-Cys3 and LAP-1 and may yield information germane to the interaction of 8-Cys domains and additional TGF-beta superfamily propeptides, an emerging paradigm for growth factor regulation.	propeptides	202-213	transforming growth factor beta 1	Homo sapiens	181-189
15161800-8	2004	CONCLUSIONS: Insulin propeptides predicted type 2 diabetes over a 7-year period in elderly men, independent of the EIR and S(i).	propeptides	21-32	insulin	Homo sapiens	13-20
14515150-0	2003	Structure-function relationships in class CA1 cysteine peptidase propeptides.	propeptides	65-76	carbonic anhydrase 1	Homo sapiens	42-45
14660587-1	2004	Propeptides of the vitamin K-dependent proteins bind to an exosite on gamma-glutamyl carboxylase; while they are bound, multiple glutamic acids in the gamma-carboxyglutamic acid (Gla) domain are carboxylated.	propeptides	0-11	gamma-glutamyl carboxylase	Homo sapiens	70-96
13129696-4	2003	RESULTS: When expressed as a percentage of baseline values, lower serum levels of the carboxy-terminal propeptides of type II collagen (CPII), and higher serum levels of the cross-linked telopeptide fragments of degraded type I collagen (CTx1) were found in the trained foals compared to the other groups.	propeptides	103-114	collagen type II alpha 1 chain	Equus caballus	118-134
12646579-2	2003	The metalloproteinase ADAMTS-2 has procollagen I N-proteinase activity capable of cleaving procollagens I and II N-propeptides in vitro, whereas mutations in the ADAMTS-2 gene in dermatosparaxis and Ehlers-Danlos syndrome VIIC show this enzyme to be responsible in vivo for most biosynthetic processing of procollagen I N-propeptides in skin.	propeptides	115-126	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	22-30
12646579-2	2003	The metalloproteinase ADAMTS-2 has procollagen I N-proteinase activity capable of cleaving procollagens I and II N-propeptides in vitro, whereas mutations in the ADAMTS-2 gene in dermatosparaxis and Ehlers-Danlos syndrome VIIC show this enzyme to be responsible in vivo for most biosynthetic processing of procollagen I N-propeptides in skin.	propeptides	115-126	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	35-61
12646579-2	2003	The metalloproteinase ADAMTS-2 has procollagen I N-proteinase activity capable of cleaving procollagens I and II N-propeptides in vitro, whereas mutations in the ADAMTS-2 gene in dermatosparaxis and Ehlers-Danlos syndrome VIIC show this enzyme to be responsible in vivo for most biosynthetic processing of procollagen I N-propeptides in skin.	propeptides	115-126	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	162-170
12456675-0	2003	Beta 2 subunit propeptides influence cooperative proteasome assembly.	propeptides	15-26	hemoglobin, beta adult minor chain	Mus musculus	0-6
12963694-3	2003	Proteolytic cleavage removes the propeptides to generate mature forms, consisting of dimers of the VEGF homology domain, that bind receptors with much greater affinity than the full-length forms.	propeptides	33-44	vascular endothelial growth factor A	Homo sapiens	99-103
12963694-5	2003	Here, we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF-D and thereby generated a mature form exhibiting greatly enhanced binding and cross-linking of VEGFR-2 and VEGFR-3 in comparison to full-length material.	propeptides	62-73	plasminogen	Homo sapiens	41-48
12963694-5	2003	Here, we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF-D and thereby generated a mature form exhibiting greatly enhanced binding and cross-linking of VEGFR-2 and VEGFR-3 in comparison to full-length material.	propeptides	62-73	vascular endothelial growth factor A	Homo sapiens	83-87
12963694-5	2003	Here, we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF-D and thereby generated a mature form exhibiting greatly enhanced binding and cross-linking of VEGFR-2 and VEGFR-3 in comparison to full-length material.	propeptides	62-73	vascular endothelial growth factor D	Homo sapiens	113-119
12637537-2	2003	Bone morphogenetic protein-1 (BMP-1) is a shorter spliced variant of mammalian tolloid (mTld), both of which cleave the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils.	propeptides	122-133	bone morphogenetic protein 1	Homo sapiens	0-28
12637537-2	2003	Bone morphogenetic protein-1 (BMP-1) is a shorter spliced variant of mammalian tolloid (mTld), both of which cleave the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils.	propeptides	122-133	bone morphogenetic protein 1	Homo sapiens	30-35
12637537-2	2003	Bone morphogenetic protein-1 (BMP-1) is a shorter spliced variant of mammalian tolloid (mTld), both of which cleave the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils.	propeptides	122-133	collagen type I alpha 2 chain	Homo sapiens	137-155
12679454-0	2003	Insulin and insulin propeptides at birth in offspring of diabetic mothers.	propeptides	20-31	insulin	Homo sapiens	12-19
12679454-2	2003	We hypothesized that insulin propeptides (proinsulin and 32-33 split proinsulin) might be more robust indicators of chronic fetal overproduction of insulin.	propeptides	29-40	insulin	Homo sapiens	21-28
12679454-2	2003	We hypothesized that insulin propeptides (proinsulin and 32-33 split proinsulin) might be more robust indicators of chronic fetal overproduction of insulin.	propeptides	29-40	insulin	Homo sapiens	42-52
12679454-2	2003	We hypothesized that insulin propeptides (proinsulin and 32-33 split proinsulin) might be more robust indicators of chronic fetal overproduction of insulin.	propeptides	29-40	insulin	Homo sapiens	69-79
12679454-2	2003	We hypothesized that insulin propeptides (proinsulin and 32-33 split proinsulin) might be more robust indicators of chronic fetal overproduction of insulin.	propeptides	29-40	insulin	Homo sapiens	45-52
12679454-4	2003	Insulin propeptides were abundant in cord blood, comprising 50% of ILM in CONTROL and 36% in ODM (P < 0.0001) and more resistant to degradation than insulin (P < 0.05).	propeptides	8-19	insulin	Homo sapiens	0-7
12679454-10	2003	Measurement of insulin propeptides may be advantageous in assessment of the influence of maternal hyperglycemia on the newborn.	propeptides	23-34	insulin	Homo sapiens	15-22
12871548-5	2003	This gene also encodes a propeptide that binds to the human gamma-glutamyl carboxylase within a range of affinities observed for mammalian propeptides.	propeptides	139-150	gamma-glutamyl carboxylase	Homo sapiens	60-86
14621392-4	2003	The biochemical markers of bone formation currently in use include bone isoenzyme of alkaline phosphatase, osteocalcin and propeptides derived from the N or C terminal ends of the type I procollagen molecule.	propeptides	123-134	collagen type I alpha 2 chain	Homo sapiens	180-198
11884132-0	2002	Protein-splicing reaction via a thiazolidine intermediate: crystal structure of the VMA1-derived endonuclease bearing the N and C-terminal propeptides.	propeptides	139-150	H(+)-transporting V1 sector ATPase subunit A	Saccharomyces cerevisiae S288C	84-88
12188906-6	2002	BCPI is a slow and tight binding inhibitor of cathepsin L-like cysteine proteinases with Ki values in picomolar range, and the inhibition is highly selective towards these proteinases just like the propeptides.	propeptides	198-209	BCP inhibitor	Bombyx mori	0-4
11724285-2	2001	Samples of 58 patients, with malignant or benign disease, were studied with specific immunoassays for the two propeptides of type-I procollagen (PICP and PINP) and with HPLC-DEAE chromatography to separate the two PINP variants.	propeptides	110-121	collagen type I alpha 2 chain	Homo sapiens	125-143
11899258-2	2001	The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.	propeptides	55-66	chromogranin A	Homo sapiens	75-89
11899258-2	2001	The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.	propeptides	55-66	chromogranin B	Homo sapiens	91-126
11574540-2	2001	VEGF-D consists of a receptor-binding domain (VEGF homology domain) and N- and C-terminal propeptides.	propeptides	90-101	vascular endothelial growth factor D	Mus musculus	0-6
11457520-2	2001	Similar studies have shown that PC5 has the ability to process a number of propeptides.	propeptides	75-86	proprotein convertase subtilisin/kexin type 5	Homo sapiens	32-35
11287666-8	2001	When translocation is observed in complexes containing a ClpP mutant whose digestion chamber is already occupied by unprocessed propeptides, a small increase in density is observed within ClpP, and RepA-associated density is also seen at other axial sites.	propeptides	128-139	replication protein RepA	Escherichia phage P1	198-202
11348875-1	2001	Furin, a yeast Kex2-family endoprotease, converts many vasoregulatory propeptides, including pro-transforming growth factor (TGF)-beta to their mature forms.	propeptides	70-81	furin, paired basic amino acid cleaving enzyme	Bos taurus	0-5
11012686-0	2000	Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides.	propeptides	82-93	cathepsin K	Homo sapiens	41-52
11330505-1	2001	The aim of this study was to examine the association between intact insulin, insulin propeptides, and femoral artery intima-media thickness.	propeptides	85-96	insulin	Homo sapiens	77-84
11519824-3	2001	However, the biological activities of TGF-beta superfamily members, TGF-beta1, -beta2 and -beta3, can be inhibited by noncovalent association with TGF-beta1, -beta2 and beta3 propeptides cleaved from the amino-termini of the TGF-beta precursor proteins.	propeptides	175-186	transforming growth factor, beta 1	Rattus norvegicus	38-46
11519824-3	2001	However, the biological activities of TGF-beta superfamily members, TGF-beta1, -beta2 and -beta3, can be inhibited by noncovalent association with TGF-beta1, -beta2 and beta3 propeptides cleaved from the amino-termini of the TGF-beta precursor proteins.	propeptides	175-186	transforming growth factor, beta 1	Rattus norvegicus	68-77
11519824-3	2001	However, the biological activities of TGF-beta superfamily members, TGF-beta1, -beta2 and -beta3, can be inhibited by noncovalent association with TGF-beta1, -beta2 and beta3 propeptides cleaved from the amino-termini of the TGF-beta precursor proteins.	propeptides	175-186	transforming growth factor, beta 1	Rattus norvegicus	68-85
11519824-4	2001	In contrast, the propeptides of other TGF-beta superfamily members do not appear to be inhibitory.	propeptides	17-28	transforming growth factor, beta 1	Rattus norvegicus	38-46
11179910-4	2000	Circulating levels of the bone formation markers carboxy-terminal and amino-terminal propeptides of type I procollagen (PICP and PINP) and the bone resorption marker cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) were assessed.	propeptides	85-96	collagen type I alpha 2 chain	Homo sapiens	100-118
10924500-5	2000	The biologically active purified protein has two sequences, coincident with the amino-terminal amino acids, respectively, of the alpha(1) and of the alpha(2) carboxyl propeptides of type I collagen, as physiologically produced by procollagen C proteinase.	propeptides	167-178	bone morphogenetic protein 1	Rattus norvegicus	230-254
11012686-3	2000	The propeptides of cathepsin S, L and K were expressed as glutathione S-transferase-fusion proteins in Escherichia coli.	propeptides	4-15	glutathione S-transferase kappa 1	Homo sapiens	58-83
11012686-5	2000	All three propeptides were tested for inhibitor potency and found to be selective within the cathepsin L subfamily (cathepsins K, L and S) compared with cathepsin B or papain.	propeptides	10-21	cathepsin L	Homo sapiens	93-104
10852914-3	2000	GILT is synthesized as a 35-kDa precursor, and following delivery to major histocompatibility complex (MHC) class II-containing compartments (MIICs), is processed to the mature 30-kDa form via cleavage of N- and C-terminal propeptides.	propeptides	223-234	IFI30 lysosomal thiol reductase	Homo sapiens	0-4
10932268-0	2000	Transient increase in procollagen propeptides in the CSF after subarachnoid hemorrhage.	propeptides	34-45	colony stimulating factor 2	Homo sapiens	53-56
10932268-2	2000	The authors therefore studied time-related changes in the CSF concentrations of type I (PICP) and type III (PIIINP) procollagen propeptides in patients with recent SAH.	propeptides	128-139	colony stimulating factor 2	Homo sapiens	58-61
10785369-3	2000	VEGF-D consists of a central receptor-binding VEGF homology domain (VHD) and N-terminal and C-terminal propeptides that are cleaved from the VHD to generate a mature, bioactive form consisting of dimers of the VHD.	propeptides	103-114	vascular endothelial growth factor D	Homo sapiens	0-6
21341053-3	2000	The regulation of MMP activity involves gene expression, proteolytic processing of the propeptides to active forms, and inhibition by specific tissue inhibitors of matrix metalloproteinase (TIMPs).	propeptides	87-98	matrix metallopeptidase 2	Homo sapiens	18-21
10617625-4	2000	However, when their propeptides were removed, mMCP-6 and mMCP-7 became enzymatically active and spontaneously assumed an approximately 150-kDa tetramer structure.	propeptides	20-31	tryptase beta 2	Mus musculus	46-52
10617625-4	2000	However, when their propeptides were removed, mMCP-6 and mMCP-7 became enzymatically active and spontaneously assumed an approximately 150-kDa tetramer structure.	propeptides	20-31	tryptase alpha/beta 1	Mus musculus	57-63
10471829-8	1999	A Western analysis using antibodies to synthetic eCATH peptides revealed the presence of eCATH-2 and eCATH-3 propeptides, but not of eCATH-1-related polypeptides, in horse neutrophil granules and in the secretions of phorbol myristate acetate-stimulated neutrophils.	propeptides	109-120	myeloid cathelicidin 3	Equus caballus	101-108
10826695-0	2000	Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides.	propeptides	104-115	caspase-1	Canis lupus familiaris	44-47
10569955-7	1999	Comparing the factor IX propeptide to the propeptides of protein C, bone Gla protein, and prothrombin, the weakest binding propeptides, allowed us to predict which residues might be responsible for these substrates" relatively weak binding to the carboxylase.	propeptides	42-53	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	57-66
10569955-7	1999	Comparing the factor IX propeptide to the propeptides of protein C, bone Gla protein, and prothrombin, the weakest binding propeptides, allowed us to predict which residues might be responsible for these substrates" relatively weak binding to the carboxylase.	propeptides	123-134	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	57-66
10569955-9	1999	The reduced binding affinity of these propeptides relative to that of FIX is due to residues -15 in protein C, -10 and -6 in bone Gla protein, and -9 in prothrombin.	propeptides	38-49	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	100-121
10563791-2	1999	Peptidylglycine monooxygenase (PHM) carries out the hydroxylation of the alpha-C atom of glycine-extended propeptides, the first step in the amidation of peptide hormones by the bifunctional enzyme peptidyl-alpha-amidating monooxygenase (PAM).	propeptides	106-117	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	31-34
10563791-2	1999	Peptidylglycine monooxygenase (PHM) carries out the hydroxylation of the alpha-C atom of glycine-extended propeptides, the first step in the amidation of peptide hormones by the bifunctional enzyme peptidyl-alpha-amidating monooxygenase (PAM).	propeptides	106-117	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	198-236
10563791-2	1999	Peptidylglycine monooxygenase (PHM) carries out the hydroxylation of the alpha-C atom of glycine-extended propeptides, the first step in the amidation of peptide hormones by the bifunctional enzyme peptidyl-alpha-amidating monooxygenase (PAM).	propeptides	106-117	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	238-241
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 6	Saccharomyces cerevisiae S288C	19-29
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 7	Saccharomyces cerevisiae S288C	41-45
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 2	Saccharomyces cerevisiae S288C	106-110
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 5	Saccharomyces cerevisiae S288C	149-153
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 1	Saccharomyces cerevisiae S288C	165-169
10500111-4	1999	The propeptides of beta6(Pre7) and beta7(Pre4) are intermediately processed to their final forms by beta2(Pup1) in the wild-type enzyme and by beta5(Pre2) and beta1(Pre3) in the beta2(Pup1) inactive mutants.	propeptides	4-15	proteasome core particle subunit beta 2	Saccharomyces cerevisiae S288C	184-188
10479448-5	1999	As previously demonstrated for BMP-1 and mTLD, mTLL-1 is shown to specifically process procollagen C-propeptides at the physiologically relevant site, while mTLL-2 is shown to lack this activity.	propeptides	101-112	tolloid-like	Mus musculus	47-53
10452902-4	1999	Activation of these subunits occurs during late assembly stages through intramolecular precursor autolysis removing propeptides attached to Thr1, which then serves as N-terminal nucleophile in substrate hydrolysis.	propeptides	116-127	homoserine kinase	Saccharomyces cerevisiae S288C	140-144
10452902-10	1999	Gain of proteolytic activity of beta1/Pre3 and beta2/Pup1 was abolished or drastically reduced, respectively, if their respective propeptides were not N-terminally bound.	propeptides	130-141	proteasome core particle subunit beta 1	Saccharomyces cerevisiae S288C	38-42
10452902-10	1999	Gain of proteolytic activity of beta1/Pre3 and beta2/Pup1 was abolished or drastically reduced, respectively, if their respective propeptides were not N-terminally bound.	propeptides	130-141	proteasome core particle subunit beta 2	Saccharomyces cerevisiae S288C	53-57
10452902-12	1999	Thus, one role for the propeptides of active beta-type subunits might be to protect the mature subunits catalytic Thr1 alpha-amino group from acetylation.	propeptides	23-34	homoserine kinase	Saccharomyces cerevisiae S288C	114-118
10393174-6	1999	Unlike the Doa3 propeptide, which is crucial for proteasome assembly, the Pre3 and Pup1 propeptides are dispensable for cell viability and proteasome formation.	propeptides	88-99	proteasome core particle subunit beta 2	Saccharomyces cerevisiae S288C	83-87
10364082-4	1999	Together with the small amounts of the free propeptides of type I procollagen, this finding indicates a low rate of collagen turnover.	propeptides	44-55	collagen type I alpha 2 chain	Homo sapiens	59-77
10188811-1	1999	OBJECTIVE: To determine whether serum or synovial fluid concentrations of chondroitin sulfate epitope 846 and carboxy propeptides of type II collagen (CPII) can be used to diagnose osteochondral fragmentation (OC) in horses.	propeptides	118-129	collagen type II alpha 1 chain	Equus caballus	133-149
9920833-8	1999	Amino acid sequencing of biosynthetically radiolabeled PR3 showed that PR3 from transfected cells is secreted after synthesis as proforms retaining amino terminal propeptides.	propeptides	163-174	proteinase 3	Homo sapiens	71-74
10757112-8	1999	In addition, we show that Hsp47 and collagen are coordinately regulated following stress via a feedback mechanism mediated by N-terminal procollagen propeptides.	propeptides	149-160	serpin family H member 1	Homo sapiens	26-31
9594087-0	1998	Evaluation of circulating type I procollagen propeptides in patients with Paget"s disease of bone.	propeptides	45-56	collagen type I alpha 2 chain	Homo sapiens	26-44
9792997-8	1998	CONCLUSIONS: Our data show a decrease in collagen synthesis with the stage of pregnancy and lower values of type I procollagen propeptides in a case of OI.	propeptides	127-138	collagen type I alpha 2 chain	Homo sapiens	108-126
10049805-5	1998	It appears that the docking of two half-proteasomes, i.e., preholoproteasome formation, is sufficient to trigger autocleavage of the Gly-1/Thr1 bond necessary for active site formation and the subsequent degradation of the propeptides.	propeptides	223-234	threonine aldolase 1, pseudogene	Homo sapiens	133-138
10049805-5	1998	It appears that the docking of two half-proteasomes, i.e., preholoproteasome formation, is sufficient to trigger autocleavage of the Gly-1/Thr1 bond necessary for active site formation and the subsequent degradation of the propeptides.	propeptides	223-234	thyroid hormone receptor beta	Homo sapiens	139-143
9822672-5	1998	Sequence comparisons of the propeptides indicated that cathepsin F and cathepsin W may form a new cathepsin subgroup.	propeptides	28-39	cathepsin F	Homo sapiens	55-66
9725916-5	1998	LTBP and the LAP propeptides of TGF-beta (isoforms 1 and 3), like many ECM proteins, contain the common integrin-binding sequence RGD.	propeptides	17-28	transforming growth factor beta 1	Homo sapiens	13-16
9725916-5	1998	LTBP and the LAP propeptides of TGF-beta (isoforms 1 and 3), like many ECM proteins, contain the common integrin-binding sequence RGD.	propeptides	17-28	transforming growth factor beta 1	Homo sapiens	32-40
9642125-8	1998	Dibasic sites also exist in the propeptides of several MMPs including proMMP-3.	propeptides	32-43	matrix metallopeptidase 3	Homo sapiens	55-59
9312130-7	1997	The VEGF-C gene structure is thus assembled from exons encoding propeptides and distinct cysteine-rich domains in addition to the VEGF homology domain, and it shows both similarities and distinct differences in comparison with other members of the VEGF/PDGF gene family.	propeptides	64-75	vascular endothelial growth factor C	Homo sapiens	4-10
9312130-7	1997	The VEGF-C gene structure is thus assembled from exons encoding propeptides and distinct cysteine-rich domains in addition to the VEGF homology domain, and it shows both similarities and distinct differences in comparison with other members of the VEGF/PDGF gene family.	propeptides	64-75	vascular endothelial growth factor A	Homo sapiens	4-8
9015309-9	1997	Furthermore, both propeptides induced rapid tyrosine phosphorylation of the Trk protein in both prostatic adenocarcinoma cells and PC12 cells, thus implicating trk in their mechanism of action.	propeptides	18-29	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	76-79
9127916-5	1997	METHODS: Specific radioimmunoassays for the amino-terminal (PINP) and carboxy-terminal (PICP) propeptides of Type I procollagen, the amino-terminal propeptide of Type III procollagen (PIIINP), and the cross-linked carboxy-terminal telopeptide of Type I collagen (ICTP) were used for serum samples obtained from 41 patients before, during, and after an active back restoration program and from 16 age- and sex-matched healthy control subjects.	propeptides	94-105	collagen type I alpha 2 chain	Homo sapiens	109-127
10931649-3	1997	This study aimed at ascertaining whether, and to what degree, the changes in the concentration of hormones listed above as well as in the concentration of sex hormone-binding globulin (SHBG) and insulin-like growth factor-I (IGF-I) affect the metabolism of collagen as evaluated indirectly from the measurement of propeptides of type I (PICP) and type III procollagen (PIIINP) in blood serum and hydroxyproline in urine.	propeptides	314-325	sex hormone binding globulin	Homo sapiens	155-183
10931649-3	1997	This study aimed at ascertaining whether, and to what degree, the changes in the concentration of hormones listed above as well as in the concentration of sex hormone-binding globulin (SHBG) and insulin-like growth factor-I (IGF-I) affect the metabolism of collagen as evaluated indirectly from the measurement of propeptides of type I (PICP) and type III procollagen (PIIINP) in blood serum and hydroxyproline in urine.	propeptides	314-325	sex hormone binding globulin	Homo sapiens	185-189
10931649-3	1997	This study aimed at ascertaining whether, and to what degree, the changes in the concentration of hormones listed above as well as in the concentration of sex hormone-binding globulin (SHBG) and insulin-like growth factor-I (IGF-I) affect the metabolism of collagen as evaluated indirectly from the measurement of propeptides of type I (PICP) and type III procollagen (PIIINP) in blood serum and hydroxyproline in urine.	propeptides	314-325	insulin like growth factor 1	Homo sapiens	225-230
9015309-9	1997	Furthermore, both propeptides induced rapid tyrosine phosphorylation of the Trk protein in both prostatic adenocarcinoma cells and PC12 cells, thus implicating trk in their mechanism of action.	propeptides	18-29	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
8865467-2	1996	Stimulation with tumour necrosis factor-alpha (TNF-alpha) and other cytokines results in the immediate release from granulocytes of a mixture of free propeptides and type 1-proPLA2 precursor.	propeptides	150-161	tumor necrosis factor	Homo sapiens	47-56
8865532-0	1996	The propeptides of human protein C, factor VII, and factor IX are exchangeable with regard to directing gamma-carboxylation of these proteins.	propeptides	4-15	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	25-46
8865532-0	1996	The propeptides of human protein C, factor VII, and factor IX are exchangeable with regard to directing gamma-carboxylation of these proteins.	propeptides	4-15	coagulation factor IX	Homo sapiens	52-61
8703986-2	1996	The 79 residue mature SP-B peptide is extremely hydrophobic and flanked by propeptides of 200 and 102 amino acids at its NH2- and COOH-termini, respectively.	propeptides	75-86	surfactant protein B	Homo sapiens	22-26
8679567-4	1996	The purified propeptides were characterized by N-terminal sequencing and mass spectrometry and correspond to incomplete forms of the proregion (87 and 81 aa for phcl-1 and phcl-2 respectively, compared to 96 aa for the complete cathepsin L propeptide).	propeptides	13-24	cathepsin L	Homo sapiens	228-239
7721762-9	1995	Comparison of the propeptides of the active constructs suggests that a particular lysine residue is important for efficient biosynthesis of proteinase A.	propeptides	18-29	proteinase A	Saccharomyces cerevisiae S288C	140-152
7636210-2	1995	The complex is comprised of latent TGF-beta binding protein (LTBP) and latent TGF-beta, which is mature TGF-beta associated noncovalently with its amino-terminal propeptides.	propeptides	162-173	latent transforming growth factor beta binding protein 1	Mus musculus	28-59
7636210-2	1995	The complex is comprised of latent TGF-beta binding protein (LTBP) and latent TGF-beta, which is mature TGF-beta associated noncovalently with its amino-terminal propeptides.	propeptides	162-173	latent transforming growth factor beta binding protein 1	Mus musculus	78-86
8159101-0	1994	Insulin propeptides in conditions associated with insulin resistance in humans and their relevance to insulin measurements.	propeptides	8-19	insulin	Homo sapiens	0-7
7495060-4	1995	PAI-1 activity was more closely associated with insulin, intact proinsulin and des 31.32 proinsulin in patients than in controls, whereas the plasma levels of fibrinogen, activated factor VII (VIIa) and VIIag were stronger correlated with insulin and insulin propeptides in subjects without coronary artery disease.	propeptides	259-270	serpin family E member 1	Homo sapiens	0-5
7495060-6	1995	Thus, our data suggests that plasma insulin and insulin propeptides might be involved in the regulation of plasma fibrinogen concentration, factor VII level and plasma PAI-1 activity.	propeptides	56-67	fibrinogen beta chain	Homo sapiens	114-124
7495060-6	1995	Thus, our data suggests that plasma insulin and insulin propeptides might be involved in the regulation of plasma fibrinogen concentration, factor VII level and plasma PAI-1 activity.	propeptides	56-67	serpin family E member 1	Homo sapiens	168-173
7851402-3	1995	Mutants of a napin gene, with deletions of different portions of the propeptides, were transformed into tobacco and napin protein was isolated.	propeptides	69-80	napin	Brassica napus	13-18
7760848-1	1995	A highly conserved ten amino acid proregion separates the peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain of the bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) protein from the NH2-terminal signal peptide; propeptides with amino acid sequences similar to the PAM proregion have been identified in other secreted proteins.	propeptides	239-250	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	58-107
7760848-1	1995	A highly conserved ten amino acid proregion separates the peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain of the bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) protein from the NH2-terminal signal peptide; propeptides with amino acid sequences similar to the PAM proregion have been identified in other secreted proteins.	propeptides	239-250	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	141-186
7760848-1	1995	A highly conserved ten amino acid proregion separates the peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain of the bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) protein from the NH2-terminal signal peptide; propeptides with amino acid sequences similar to the PAM proregion have been identified in other secreted proteins.	propeptides	239-250	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	188-191
7760848-1	1995	A highly conserved ten amino acid proregion separates the peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain of the bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) protein from the NH2-terminal signal peptide; propeptides with amino acid sequences similar to the PAM proregion have been identified in other secreted proteins.	propeptides	239-250	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	292-295
8159101-0	1994	Insulin propeptides in conditions associated with insulin resistance in humans and their relevance to insulin measurements.	propeptides	8-19	insulin	Homo sapiens	50-57
8159101-0	1994	Insulin propeptides in conditions associated with insulin resistance in humans and their relevance to insulin measurements.	propeptides	8-19	insulin	Homo sapiens	102-109
8159101-1	1994	Routine insulin assays measure not only biologically active insulin but also the relatively inactive propeptides, proinsulin and desdipeptide proinsulin.	propeptides	101-112	insulin	Homo sapiens	8-15
8159101-4	1994	We have measured plasma insulin levels using a routine assay, together with measurements of the major circulating insulin propeptides, intact proinsulin and des 31,32proinsulin, in various clinical situations associated with apparently increased insulin levels and insulin resistance.	propeptides	122-133	insulin	Homo sapiens	114-121
8159101-4	1994	We have measured plasma insulin levels using a routine assay, together with measurements of the major circulating insulin propeptides, intact proinsulin and des 31,32proinsulin, in various clinical situations associated with apparently increased insulin levels and insulin resistance.	propeptides	122-133	insulin	Homo sapiens	114-121
8159101-4	1994	We have measured plasma insulin levels using a routine assay, together with measurements of the major circulating insulin propeptides, intact proinsulin and des 31,32proinsulin, in various clinical situations associated with apparently increased insulin levels and insulin resistance.	propeptides	122-133	insulin	Homo sapiens	114-121
8276852-10	1994	The 9-residue propeptide sequence that inhibits the membrane association of procathepsin L at pH 5 resembles the vacuolar sorting sequences in the propeptides of yeast proteinase A and carboxypeptidase Y.	propeptides	147-158	proteinase A	Saccharomyces cerevisiae S288C	168-180
8328306-3	1993	The amino-terminal propeptides of pro-alpha 1 and pro-alpha 2 chains of type I procollagen are phosphorylated and those of the pro-alpha 1 and pN-alpha 1 chains of type III procollagen both phosphorylated and sulfated, there being no difference in net charge in the propeptides between these cell types.	propeptides	19-30	collagen type I alpha 2 chain	Homo sapiens	72-90
8268229-0	1993	Genomic sequence of mouse COL1A1 encoding the collagen propeptides.	propeptides	55-66	collagen, type I, alpha 1	Mus musculus	26-32
8328306-3	1993	The amino-terminal propeptides of pro-alpha 1 and pro-alpha 2 chains of type I procollagen are phosphorylated and those of the pro-alpha 1 and pN-alpha 1 chains of type III procollagen both phosphorylated and sulfated, there being no difference in net charge in the propeptides between these cell types.	propeptides	266-277	collagen type I alpha 2 chain	Homo sapiens	72-90
1615759-2	1992	The major proteins secreted by normal human osteoblasts from adult trabecular bone were identified by N-terminal sequencing to be gelatinase, osteonectin, the C-terminal propeptides of the alpha 1 and alpha 2 chains of type I collagen, tissue inhibitor of metalloproteinase 1 (TIMP-1), and beta 2-microglobulin.	propeptides	170-181	adrenoceptor alpha 1D	Homo sapiens	189-208
1389209-14	1992	These results demonstrate the use of a synthetic peptide to generate specific antiserum against more hydrophilic domains of pro-SP-C sequences and confirm that SP-C propeptides are unique to the lung.	propeptides	165-176	surfactant protein C	Rattus norvegicus	160-164
1325651-1	1992	PACE (paired basic amino acid cleaving enzyme) is a subtilisin-like serine protease involved in processing of propeptides in the constitutive secretory pathway.	propeptides	110-121	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-4
1325651-1	1992	PACE (paired basic amino acid cleaving enzyme) is a subtilisin-like serine protease involved in processing of propeptides in the constitutive secretory pathway.	propeptides	110-121	furin, paired basic amino acid cleaving enzyme	Homo sapiens	6-45
1325651-1	1992	PACE (paired basic amino acid cleaving enzyme) is a subtilisin-like serine protease involved in processing of propeptides in the constitutive secretory pathway.	propeptides	110-121	coagulation factor II, thrombin	Homo sapiens	68-83
1642226-1	1992	Dermatosparaxis is a recessively inherited connective-tissue disorder that results from lack of the activity of type I procollagen N-proteinase, the enzyme that removes the amino-terminal propeptides from type I procollagen.	propeptides	188-199	collagen type I alpha 2 chain	Homo sapiens	112-130
1642226-1	1992	Dermatosparaxis is a recessively inherited connective-tissue disorder that results from lack of the activity of type I procollagen N-proteinase, the enzyme that removes the amino-terminal propeptides from type I procollagen.	propeptides	188-199	collagen type I alpha 2 chain	Homo sapiens	205-223
1615759-8	1992	The major proteins secreted by normal fetal osteoblastic cells were identified by N-terminal sequencing to be osteonectin and the C-terminal propeptides of the alpha 1 and alpha 2 chains of type I collagen.	propeptides	141-152	adrenoceptor alpha 1D	Homo sapiens	160-179
1666284-6	1991	The removal of a portion of propeptides results in conformational changes around the Gln80-Phe81 and His82-Phe83 bonds in respective intermediates of MMP-1 and MMP-3 and render them to rapid specific cleavage by MMP-3 to generate stable, fully active enzymes.	propeptides	28-39	matrix metallopeptidase 1	Homo sapiens	150-155
1993671-2	1991	We have demonstrated previously that the carboxyl- and amino-terminal propeptides of type I procollagen can inhibit procollagen synthesis by specifically decreasing procollagen mRNA levels.	propeptides	70-81	collagen type I alpha 2 chain	Homo sapiens	85-103
1368103-0	1992	Production and biological activity of hybrid growth hormone-releasing hormone propeptides.	propeptides	78-89	gonadotropin releasing hormone receptor	Rattus norvegicus	45-59
1368103-5	1992	These hybrid GHRH propeptides (proGHRH) are comprised of an analog of GHRH (44 aa) and the human GHRH carboxy-terminal peptide (33 aa).	propeptides	18-29	growth hormone releasing hormone	Homo sapiens	13-17
1368103-5	1992	These hybrid GHRH propeptides (proGHRH) are comprised of an analog of GHRH (44 aa) and the human GHRH carboxy-terminal peptide (33 aa).	propeptides	18-29	growth hormone releasing hormone	Homo sapiens	34-38
1368103-5	1992	These hybrid GHRH propeptides (proGHRH) are comprised of an analog of GHRH (44 aa) and the human GHRH carboxy-terminal peptide (33 aa).	propeptides	18-29	growth hormone releasing hormone	Homo sapiens	34-38
1666284-6	1991	The removal of a portion of propeptides results in conformational changes around the Gln80-Phe81 and His82-Phe83 bonds in respective intermediates of MMP-1 and MMP-3 and render them to rapid specific cleavage by MMP-3 to generate stable, fully active enzymes.	propeptides	28-39	matrix metallopeptidase 3	Homo sapiens	160-165
1666284-6	1991	The removal of a portion of propeptides results in conformational changes around the Gln80-Phe81 and His82-Phe83 bonds in respective intermediates of MMP-1 and MMP-3 and render them to rapid specific cleavage by MMP-3 to generate stable, fully active enzymes.	propeptides	28-39	matrix metallopeptidase 3	Homo sapiens	212-217
2558646-4	1989	hTSH beta propeptides without C-terminal extension were glycosylated, associated with alpha subunit and secreted, as normal propeptides were, and its heterodimer with alpha subunit showed normal TSH bioactivity in FRTL-5 bioassay.	propeptides	10-21	thyroid stimulating hormone subunit beta	Homo sapiens	0-9
2268273-1	1990	In this study synthetic propeptides were used to investigate gamma-carboxylation of the prothrombin and factor X precursors in rat liver microsomes.	propeptides	24-35	coagulation factor II	Rattus norvegicus	88-99
2318855-0	1990	In vivo and in vitro noncovalent association of excised alpha 1 (I) amino-terminal propeptides with mutant pN alpha 2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII.	propeptides	83-94	collagen type I alpha 2 chain	Homo sapiens	110-129
35361882-2	2022	BMP1 mediates the cleavage of carboxyl terminal (C-term) propeptides from procollagens, a crucial step in fibrillar collagen fiber formation.	propeptides	57-68	bone morphogenetic protein 1	Mus musculus	0-4
35181633-0	2022	Visualized procollagen Ialpha1 demonstrates the intracellular processing of propeptides.	propeptides	76-87	INSM transcriptional repressor 1	Homo sapiens	23-30
2558646-4	1989	hTSH beta propeptides without C-terminal extension were glycosylated, associated with alpha subunit and secreted, as normal propeptides were, and its heterodimer with alpha subunit showed normal TSH bioactivity in FRTL-5 bioassay.	propeptides	124-135	thyroid stimulating hormone subunit beta	Homo sapiens	0-9
2668946-7	1989	By contrast, the N- and C-terminal propeptides of the IAPP precursor show very little sequence conservation, which suggests that these regions do not represent additional biologically active molecules.	propeptides	35-46	islet amyloid polypeptide	Homo sapiens	54-58
3817157-0	1987	Identification of disulfide bonds in carboxy-terminal propeptides of human type I procollagen.	propeptides	54-65	collagen type I alpha 2 chain	Homo sapiens	75-93
3316206-2	1987	Type I procollagen was purified from the medium of cultured human fibroblasts incubated with 14C-labeled amino acids, the NH2-terminal propeptides were cleaved with procollagen N-proteinase, and the resulting pC-collagen was isolated by gel filtration chromatography.	propeptides	135-146	collagen type I alpha 2 chain	Homo sapiens	0-18
3301066-5	1987	Precursors containing basic propeptides such as proinsulin or proalbumin may also appear.	propeptides	28-39	insulin	Homo sapiens	48-58
3317405-12	1987	The demonstration that two structures common to vitamin K-dependent proteins, the homologous propeptides domain and the invariant EXXXEXC unit, are in mature MGP indicates that des-gamma-carboxy-MGP should be an excellent in vitro gamma-carboxylase substrate for analysis of mechanisms involved in substrate recognition and product dissociation.	propeptides	93-104	matrix Gla protein	Rattus norvegicus	158-161
3586016-6	1987	The most highly conserved sequences of the alpha 1(I), alpha 2(I), alpha 1(II), alpha 1(III) and alpha 2(V) COOH-propeptides include regions surrounding the carbohydrate attachment site, cysteine-containing regions and the COOH-terminal sequences.	propeptides	113-124	collagen type V alpha 2 chain	Homo sapiens	97-107
2952112-8	1987	Since hormonal propeptides usually undergo intracellular processing, and the matured peptides are subsequently stored in the secretory granules, these results indicate that the processing pathway of ANF may be different from that of other hormonal peptides.	propeptides	15-26	natriuretic peptide A	Rattus norvegicus	199-202
3817157-1	1987	Intra-chain and inter-chain disulfide bonds within the carboxy-terminal propeptides of human type I procollagen were studied using cyanogen bromide cleavage of the propeptides and electrophoresis on SDS-polyacrylamide/glycerol gels.	propeptides	72-83	collagen type I alpha 2 chain	Homo sapiens	93-111
3817157-1	1987	Intra-chain and inter-chain disulfide bonds within the carboxy-terminal propeptides of human type I procollagen were studied using cyanogen bromide cleavage of the propeptides and electrophoresis on SDS-polyacrylamide/glycerol gels.	propeptides	164-175	collagen type I alpha 2 chain	Homo sapiens	93-111
3002711-1	1985	A protocol is offered for the isolation of the carboxyterminal propeptides of human type I procollagen and the development of an antibody specific for these propeptides.	propeptides	63-74	collagen type I alpha 2 chain	Homo sapiens	84-102
3733716-2	1986	Amino- and carboxyl-terminal type I procollagen propeptides were isolated and purified from chick calvaria and tendon cultures.	propeptides	48-59	collagen type I alpha 2 chain	Homo sapiens	29-47
3019385-0	1986	Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.	propeptides	112-123	endogenous retrovirus group K member 7	Homo sapiens	71-81
3019385-0	1986	Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.	propeptides	112-123	collagen type I alpha 2 chain	Homo sapiens	129-147
3002711-1	1985	A protocol is offered for the isolation of the carboxyterminal propeptides of human type I procollagen and the development of an antibody specific for these propeptides.	propeptides	157-168	collagen type I alpha 2 chain	Homo sapiens	84-102
3875856-5	1985	A stretch of 9 residues proximal to the NH2 terminus of secreted BGP is strikingly similar to the corresponding regions in known propeptides of the gamma-carboxyglutamic acid-containing blood coagulation factors.	propeptides	129-140	bone gamma-carboxyglutamate protein	Rattus norvegicus	65-68
3918028-2	1985	Procollagen N-proteinase, the enzyme which cleaves the NH2-terminal propeptides from type I procollagen, was purified over 15,000-fold from extracts of chick embryos by chromatography on columns of DEAE-cellulose, concanavalin A-agarose, heparin-agarose, pN-collagen-agarose, and a filtration gel.	propeptides	68-79	collagen type I alpha 2 chain	Homo sapiens	85-103
6096378-3	1984	The apo-A-II prosegment resembles the propeptides of prohormones and proalbumin: it ends with paired basic amino acids.	propeptides	38-49	apolipoprotein A2	Homo sapiens	4-12
32911580-5	2020	As a result, various myostatin-targeting strategies involving antibodies, myostatin propeptides, soluble receptors, and endogenous antagonists have been generated, and many of them have progressed to clinical trials.	propeptides	84-95	myostatin	Homo sapiens	21-30
6418743-7	1983	Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains.	propeptides	141-152	PROA	Homo sapiens	25-34
6418743-7	1983	Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains.	propeptides	141-152	collagen type I alpha 2 chain	Homo sapiens	69-87
6418743-7	1983	Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains.	propeptides	279-290	collagen type I alpha 2 chain	Homo sapiens	69-87
6418743-7	1983	Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains.	propeptides	279-290	PROA	Homo sapiens	180-189
6418743-7	1983	Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains.	propeptides	279-290	PROA	Homo sapiens	180-189
6773953-2	1980	Fibroblasts cultured from the patient"s skin produced type I procollagen in which the NH2-terminal propeptide of pro alpha 2 was cleaved to about half of normal values by chick procollagen neutral protease which removes the NH2-terminal propeptides from procollagen (N-protease).	propeptides	237-248	collagen type I alpha 2 chain	Homo sapiens	54-72
33846632-7	2021	These structures reveal the architecture and positions of Ump1 and beta2/beta5 propeptides, with important implications for their functions.	propeptides	79-90	homeodomain mating type protein a2	Saccharomyces cerevisiae S288C	67-72
33846632-9	2021	These results reveal how the coordinated activity of Ump1, Pba1 and the active site propeptides orchestrate key aspects of CP assembly.	propeptides	84-95	Ump1p	Saccharomyces cerevisiae S288C	53-57
33672235-2	2021	Proteolysis is most prominent among the lymph-angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors.	propeptides	178-189	vascular endothelial growth factor C	Homo sapiens	57-63
33672235-2	2021	Proteolysis is most prominent among the lymph-angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors.	propeptides	178-189	vascular endothelial growth factor D	Homo sapiens	68-74
33206546-2	2021	Bone morphogenic protein 1 (BMP1) is a metalloprotease that plays an important role in the cleavage of carboxy-terminal (COOH-terminal) propeptides from procollagens.	propeptides	136-147	bone morphogenetic protein 1	Homo sapiens	0-26
33206546-2	2021	Bone morphogenic protein 1 (BMP1) is a metalloprotease that plays an important role in the cleavage of carboxy-terminal (COOH-terminal) propeptides from procollagens.	propeptides	136-147	bone morphogenetic protein 1	Homo sapiens	28-32
6587351-6	1984	Cathepsin D was purified 907-fold from chicken livers by affinity chromatography on pepstatin-aminohexyl-Sepharose 4B and was found to remove the COOH propeptides from procollagen.	propeptides	151-162	cathepsin D	Gallus gallus	0-11
33250771-1	2020	Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy.	propeptides	128-139	myostatin	Mus musculus	14-24
33250771-1	2020	Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy.	propeptides	128-139	SMAD family member 2	Mus musculus	46-53
31152061-2	2019	A critical step in collagen fibril formation is the proteolytic removal of N- and C-terminal propeptides from procollagens by metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and BMP1 (bone morphogenetic protein 1)/Tolloid-like families, respectively.	propeptides	93-104	bone morphogenetic protein 1	Homo sapiens	228-232
30393914-1	2019	BACKGROUND: Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55 kDa glycoprotein, which increases the activity of procollagen C-proteinases that break down C-terminal propeptides.	propeptides	168-179	procollagen C-endopeptidase enhancer	Homo sapiens	12-47
30393914-1	2019	BACKGROUND: Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55 kDa glycoprotein, which increases the activity of procollagen C-proteinases that break down C-terminal propeptides.	propeptides	168-179	procollagen C-endopeptidase enhancer	Homo sapiens	49-55
31152061-2	2019	A critical step in collagen fibril formation is the proteolytic removal of N- and C-terminal propeptides from procollagens by metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and BMP1 (bone morphogenetic protein 1)/Tolloid-like families, respectively.	propeptides	93-104	bone morphogenetic protein 1	Homo sapiens	234-262
30422384-0	2019	Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B. Matrix metalloproteinases (MMPs) are secreted as proenzymes, containing propeptides that interact with the catalytic zinc, thereby controlling MMP activation.	propeptides	187-198	matrix metallopeptidase 3	Homo sapiens	142-146
30204931-8	2018	This disruption of coronary formation correlates with abnormal processing of VEGF-C propeptides, suggesting VEGF-C-dependent signaling alteration.	propeptides	84-95	vascular endothelial growth factor C	Mus musculus	77-83
30204931-8	2018	This disruption of coronary formation correlates with abnormal processing of VEGF-C propeptides, suggesting VEGF-C-dependent signaling alteration.	propeptides	84-95	vascular endothelial growth factor C	Mus musculus	108-114
29975661-5	2018	Both systems allowed the subsequent purification of soluble pro-KLK zymogens with correct propeptides and of the mature forms.	propeptides	90-101	kallikrein related peptidase 11	Homo sapiens	64-67
29350268-2	2018	MMPs are synthesized as inactive precursors with auto-inhibitory N-terminal propeptides, the proteolytic removal of which exposes the catalytic zinc ion, rendering the protease active.	propeptides	76-87	matrix metallopeptidase 2	Danio rerio	0-4
29174671-2	2018	The human IGF-I gene gives rise to three IGF-I propeptides (proIGF-IA, proIGF-IB and proIGF-IC) that are cleaved to create mature IGF-I.	propeptides	47-58	insulin like growth factor 1	Homo sapiens	10-15
29174671-2	2018	The human IGF-I gene gives rise to three IGF-I propeptides (proIGF-IA, proIGF-IB and proIGF-IC) that are cleaved to create mature IGF-I.	propeptides	47-58	insulin like growth factor 1	Homo sapiens	41-46
29174671-2	2018	The human IGF-I gene gives rise to three IGF-I propeptides (proIGF-IA, proIGF-IB and proIGF-IC) that are cleaved to create mature IGF-I.	propeptides	47-58	insulin like growth factor 1	Homo sapiens	41-46
29174671-7	2018	RESULTS: Secreted IGF-I propeptides stimulated articular chondrocyte biosynthetic activity to the same degree as mature IGF-I.	propeptides	24-35	insulin like growth factor 1	Homo sapiens	18-23
29174671-8	2018	Of the three IGF-I propeptides, only one, proIGF-IA, strongly bound to heparin.	propeptides	19-30	insulin like growth factor 1	Homo sapiens	13-18
28281531-3	2017	Here, by structural and mutagenic analysis, we identify key amino acid residues in the alpha1 and alpha2 C-propeptides that determine homo- and heterotrimerization.	propeptides	107-118	adrenoceptor alpha 1D	Homo sapiens	87-106
29207979-8	2017	These newly-mined propeptides were introduced after the N-terminal USP45 secretion signal to characterize and compare their effects on the secretion of Escherichia coli thioredoxin (TRX) and Flavobacterium meningosepticum prolyl endopeptidase (Fm PEP) in Lactococcus lactis NZ9000.	propeptides	18-29	usp45	Lactococcus lactis	67-72
28223360-9	2017	SPI-1 thus resembles SBT propeptides with respect to its mode of protease inhibition.	propeptides	25-36	Spi-1 proto-oncogene	Bos taurus	0-5
28215295-6	2017	The findings regarding the BDNF propeptide would provide new insights for understanding the mechanisms of action of the propeptides of growth factors as well as the biological roles of neurotrophins.	propeptides	120-131	brain derived neurotrophic factor	Homo sapiens	27-31
27838145-0	2017	Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients.	propeptides	23-34	sortilin 1	Homo sapiens	6-14
26147827-2	2016	On the one hand, the sequences encoding the propeptides SD or LEISSTCDA were inserted between the sequence encoding the signal peptide of Usp45 and the structural gene of the mature pediocin PA-1.	propeptides	44-55	usp45	Lactococcus lactis	138-143
27826753-5	2016	However, the other IL-1 members, except for IL-37 (also known as IL-1F7), have relatively short propeptides with fewer than 40 amino acid residues at the N-terminus.	propeptides	96-107	interleukin 37	Homo sapiens	44-49
27826753-5	2016	However, the other IL-1 members, except for IL-37 (also known as IL-1F7), have relatively short propeptides with fewer than 40 amino acid residues at the N-terminus.	propeptides	96-107	interleukin 37	Homo sapiens	65-71
27212026-3	2016	We found that FOXL2 interacts with specific C-terminal propeptides of several fibrillary collagens.	propeptides	55-66	forkhead box L2	Mus musculus	14-19
27212026-4	2016	Because these propeptides can participate in feedback regulation of collagen biosynthesis, we inferred that FOXL2 could thereby affect the transcription of the cognate collagen genes.	propeptides	14-25	forkhead box L2	Mus musculus	108-113
25537662-7	2015	Both the PSA and PSMA activated propeptides were found to be cytotoxic to prostate cancer cells in vitro.	propeptides	32-43	folate hydrolase 1	Homo sapiens	17-21
26100281-0	2016	Neurotrophin Propeptides: Biological Functions and Molecular Mechanisms.	propeptides	13-24	brain derived neurotrophic factor	Homo sapiens	0-12
26100281-3	2016	Although the signal peptide functions have been well studied, the role of neurotrophin propeptides is not so clear.	propeptides	87-98	brain derived neurotrophic factor	Homo sapiens	74-86
26100281-4	2016	Here, we briefly summarize the biochemistry of neurotrophin propeptides, including their role as folding-assistants for the mature factor and their role in processing and in secretion of neurotrophins.	propeptides	60-71	brain derived neurotrophic factor	Homo sapiens	47-59
26100281-5	2016	In the main part of the review we summarize our current state of knowledge of the biological activity of neurotrophin propeptides, their possible mechanisms of action, and their potential influence on the activity of the mature neurotrophins.	propeptides	118-129	brain derived neurotrophic factor	Homo sapiens	105-117
26110992-0	2015	Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.	propeptides	45-56	furin, paired basic amino acid cleaving enzyme	Homo sapiens	60-65
26110992-6	2015	In this manuscript, we measured the pKa values of histidines within the propeptides of furin and proprotein convertase 1/3 using a histidine hydrogen-deuterium exchange mass spectrometry approach.	propeptides	72-83	furin, paired basic amino acid cleaving enzyme	Homo sapiens	87-92
30775467-5	2016	Crosslinked C-terminal telopeptides of type I collagen (CTX-I) and N-terminal propeptides of type I procollagen (PINP) level were measured at baseline and at 1 week after 3-month training.	propeptides	78-89	collagen type I alpha 2 chain	Homo sapiens	93-111
23682772-6	2013	RESULTS: We discovered that the proteins encoded by hGGT2 and its variants are inactive propeptides.	propeptides	88-99	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	52-57
25446080-1	2015	The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides.	propeptides	232-243	stabilin 2	Homo sapiens	4-39
25446080-1	2015	The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides.	propeptides	232-243	stabilin 2	Homo sapiens	41-45
25446080-1	2015	The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides.	propeptides	232-243	stabilin 2	Homo sapiens	51-61
24450584-3	2014	VEGF-D contains a central VEGF homology domain, which is the biologically active domain, with flanking N- and C-terminal propeptides.	propeptides	121-132	vascular endothelial growth factor D	Homo sapiens	0-6
24450584-3	2014	VEGF-D contains a central VEGF homology domain, which is the biologically active domain, with flanking N- and C-terminal propeptides.	propeptides	121-132	vascular endothelial growth factor A	Homo sapiens	0-4
24403064-5	2014	Strikingly, Anxa6 knockdown also abrogated PE-induced juxtanuclear accumulation of secretory granules (SG) containing ANP propeptides (pro-ANP), a signature of maladaptive hypertrophy having counteractive functions.	propeptides	122-133	annexin A6	Homo sapiens	12-17
24403064-5	2014	Strikingly, Anxa6 knockdown also abrogated PE-induced juxtanuclear accumulation of secretory granules (SG) containing ANP propeptides (pro-ANP), a signature of maladaptive hypertrophy having counteractive functions.	propeptides	122-133	natriuretic peptide A	Homo sapiens	118-121
25146735-1	2014	The type I procollagen carboxyterminal(C-)propeptides are crucial in directing correct assembly of the procollagen heterotrimers.	propeptides	42-53	collagen type I alpha 2 chain	Homo sapiens	4-22
23682772-7	2013	We show that hGGT2 cDNAs are transcribed with a similar efficiency to hGGT1, and the expressed propeptides are N-glycosylated.	propeptides	95-106	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	13-18
24043621-2	2013	The folding mechanism of type I procollagen has been well characterized, and protein disulfide isomerase (PDI) has been suggested as a key player in the formation of the correct disulfide bonds in the noncollagenous carboxyl-terminal and amino-terminal propeptides.	propeptides	253-264	collagen type I alpha 2 chain	Homo sapiens	25-43
24043621-2	2013	The folding mechanism of type I procollagen has been well characterized, and protein disulfide isomerase (PDI) has been suggested as a key player in the formation of the correct disulfide bonds in the noncollagenous carboxyl-terminal and amino-terminal propeptides.	propeptides	253-264	prolyl 4-hydroxylase subunit beta	Homo sapiens	77-104
24043621-2	2013	The folding mechanism of type I procollagen has been well characterized, and protein disulfide isomerase (PDI) has been suggested as a key player in the formation of the correct disulfide bonds in the noncollagenous carboxyl-terminal and amino-terminal propeptides.	propeptides	253-264	prolyl 4-hydroxylase subunit beta	Homo sapiens	106-109