PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11790377-3	2002	ReN 1869 at 0.01-10 mg/kg is antinociceptive in tests of chemical nociception in rodents (formalin, capsaicin, phenyl quinone writhing) but not in thermal tests (hot plate and tail flick).	phenylbenzoquinone	111-125	renin 1 structural	Mus musculus	0-3
18511039-8	2008	Subsequently, it was observed that the PBQ - but not the acetic acid-induced writhes were diminished in IL-18 deficient ((-/-)) mice.	phenylbenzoquinone	39-42	interleukin 18	Mus musculus	104-109
18511039-11	2008	Thus, IL-18, IFN-gamma, endothelin acting on endothelin ETA and ETB receptors, and prostanoids mediate PBQ-induced writhing response in mice.	phenylbenzoquinone	103-106	interleukin 18	Mus musculus	6-11
18511039-11	2008	Thus, IL-18, IFN-gamma, endothelin acting on endothelin ETA and ETB receptors, and prostanoids mediate PBQ-induced writhing response in mice.	phenylbenzoquinone	103-106	interferon gamma	Mus musculus	13-22
11720094-2	2001	These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception.	phenylbenzoquinone	128-146	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	234-237
9661217-0	1998	Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.	phenylbenzoquinone	99-112	prostaglandin-endoperoxide synthase 1	Mus musculus	42-58
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	0-18	endothelin receptor type B	Mus musculus	75-80
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	0-18	endothelin receptor type B	Mus musculus	131-136
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	0-18	endothelin receptor type B	Mus musculus	131-136
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	20-23	endothelin receptor type B	Mus musculus	75-80
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	20-23	endothelin receptor type B	Mus musculus	131-136
11078342-3	2000	Phenylbenzoquinone (PBQ)-induced algesia was evident in the wild-type (WT) ET(B) (+/+) mice, attenuated by 80% in the heterozygous ET(B) (+/-) mice, and absent in the ET(B) (-/-) homozygotes.	phenylbenzoquinone	20-23	endothelin receptor type B	Mus musculus	131-136
11078342-4	2000	This was reproduced pharmacologically in WT ET(B) (+/+) mice where the algesic effect of PBQ was inhibited 74% by A192621, but unaffected by SB 234551 (both at 25 mg/kg p.o.).	phenylbenzoquinone	89-92	endothelin receptor type B	Mus musculus	44-49
10663393-3	2000	In addition, PHQ and PBQ were able to generate DNA single-strand breaks (DNA SSB), while OPP failed to induce this lesion.	phenylbenzoquinone	21-24	lupus La protein	Cricetulus griseus	77-80
9704822-1	1998	The genotoxic potential of two occupationally significant chemicals, 4,4"-methylene-bis-2-chloroaniline (MOCA) and 2-phenyl-1,4-benzoquinone (PBQ), was explored by monitoring the induction of mutations at the HPRT locus of AHH-1 human lymphoblastoid cells.	phenylbenzoquinone	115-140	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	209-213
10334203-5	1999	Using 32P-5"-end-labeled DNA fragments obtained from human p53 tumor suppressor gene and c-Ha-ras-1 protooncogene, we showed that PBQ plus NADH, and also PHQ, induced DNA damage frequently at thymine residues, in the presence of Cu(II).	phenylbenzoquinone	130-133	tumor protein p53	Homo sapiens	59-62
10334203-5	1999	Using 32P-5"-end-labeled DNA fragments obtained from human p53 tumor suppressor gene and c-Ha-ras-1 protooncogene, we showed that PBQ plus NADH, and also PHQ, induced DNA damage frequently at thymine residues, in the presence of Cu(II).	phenylbenzoquinone	130-133	HRas proto-oncogene, GTPase	Homo sapiens	89-99
4062439-2	1985	administered Asn-Ala-Gly-Ala (NAGA), a partial sequence of beta-lipotropin, was investigated using the tail-pressure, hot-plate and phenylbenzoquinone (PBQ)-induced writhing tests in mice.	phenylbenzoquinone	132-150	N-acetyl galactosaminidase, alpha	Mus musculus	30-34
9364413-3	1997	SM1 and SM3 showed analgesic properties in the phenylbenzoquinone-induced abdominal constriction test (ED50 approximately 10-15 mg kg-1, i.p.)	phenylbenzoquinone	47-65	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	0-3
9364413-6	1997	Acute intraperitoneal administration of both compounds (1 mg kg-1 SM1 or 1.5 mg kg-1 SM3) potentiated morphine (0.15 mg kg-1, s.c.) analgesia in the phenylbenzoquinone test.	phenylbenzoquinone	149-167	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	66-69
7523918-4	1994	In order to further investigate the metabolic activation and genotoxic effects of OPP, we have investigated the ability of PHQ and PBQ to induce micronuclei and mutations at the HGPRT locus in a prostaglandin H synthase-containing V79 Chinese hamster lung fibroblast cell line.	phenylbenzoquinone	131-134	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	178-183
8365458-1	1993	Recombinant human interleukin-1 alpha (rHu-IL-1 alpha) has been indicated to produce central antinociception in the mouse phenylquinone writhing test, the antinociception being unaffected by naloxone.	phenylbenzoquinone	122-135	interleukin 1 alpha	Homo sapiens	18-37
7602473-15	1995	PC4 and PC13 showed analgesic properties in the phenylbenzoquinone-induced abdominal constriction test (5.0 < ED50 < 5.5 mg kg-1, i.p.)	phenylbenzoquinone	48-66	proprotein convertase subtilisin/kexin type 4	Mus musculus	0-3
1906235-1	1991	The analgetic activity of inhibitors of 5-lipoxygenase (5-LO) and cyclooxygenase (CO) was investigated using rat Randall-Selitto (RS) hyperalgesia and mouse phenylbenzoquinone (PBQ)-induced abdominal constriction assays.	phenylbenzoquinone	177-180	arachidonate 5-lipoxygenase	Rattus norvegicus	40-54
3257266-10	1988	), a time point in which a CGRP-induced decrease in 45Ca++ uptake was observed, slightly potentiated morphine in the tail-flick and hot-plate tests, but not in the p-phenylquinone test.	phenylbenzoquinone	166-179	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	27-31
4062439-2	1985	administered Asn-Ala-Gly-Ala (NAGA), a partial sequence of beta-lipotropin, was investigated using the tail-pressure, hot-plate and phenylbenzoquinone (PBQ)-induced writhing tests in mice.	phenylbenzoquinone	152-155	N-acetyl galactosaminidase, alpha	Mus musculus	30-34
4062439-6	1985	NAGA showed a prominent reduction in activity on the PBQ writhing as compared with the hot-plate and tail-pressure tests.	phenylbenzoquinone	53-56	N-acetyl galactosaminidase, alpha	Mus musculus	0-4
30685680-4	2019	Most importantly, nine novel by-products including one chlorobenzoquinone, four phenyl benzoquinones, and four polycyclic aromatic hydrocarbons were formed during BP-1 chlorination.	phenylbenzoquinone	80-100	BP1	Homo sapiens	163-167
24059442-5	2013	Thus, we examined the effects of four phenylbenzoquinones on the ability of hSULT2A1 to catalyze the sulfation of the endogenous substrate, dehydroepiandrosterone (DHEA).	phenylbenzoquinone	38-57	sulfotransferase family 2A member 1	Homo sapiens	76-84