PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3141381-1	1988	The synthesis of glycine betaine, a powerful osmoprotectant, from its precursor, choline, is a function of the bet genes.	osmoprotectant	45-59	putative DNA recombination protein Bet	Escherichia coli	25-28
33626482-4	2021	We first demonstrate that under nonstress conditions cry1a regulates seedling growth by mechanisms that involve pigmentation, lipid peroxidation and osmoprotectant accumulation in a blue light-dependent manner.	osmoprotectant	149-163	cryptochrome 1	Solanum lycopersicum	53-58
33389495-1	2021	The enzyme betaine aldehyde dehydrogenase (BADH EC 1.2.1.8) catalyzes the synthesis of glycine betaine (GB), an osmolyte and osmoprotectant.	osmoprotectant	125-139	aldehyde dehydrogenase 7 family member A1	Homo sapiens	11-41
33577334-0	2021	Osmoprotectant Coated Thermostable Gold Nanoparticles Efficiently Restrict Temperature-Induced Amyloid Aggregation of Insulin.	osmoprotectant	0-14	insulin	Homo sapiens	118-125
33577334-4	2021	Both quenching and docking experiments suggest a direct interaction between the osmoprotectant-coated nanoparticles and aggregation-prone hydrophobic stretches of insulin.	osmoprotectant	80-94	insulin	Homo sapiens	163-170
33577334-7	2021	The results signify the protection of the exposed aggregation-prone domains of insulin from temperature-induced self-assembly through osmoprotectant-coated nanoparticles, and such effect may inspire the development of osmolyte-based antiamyloid nanoformulations.	osmoprotectant	134-148	insulin	Homo sapiens	79-86
30409967-6	2018	Systematic analyses reveal that upon drought stress, increased BRL3 triggers the accumulation of osmoprotectant metabolites including proline and sugars.	osmoprotectant	97-111	BRI1-like 3	Arabidopsis thaliana	63-67
28266015-7	2017	Addition of betaine, an osmoprotectant, to the hyperosmotic culture significantly increased the proportion of highly sialylated and tetra-antennary N-linked glycans (P <= 0.05), while it increased the expression of the N-glycan branching/antennary genes (mgat2 and mgat4b).	osmoprotectant	24-38	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	258-263
25313392-3	2015	These include six genes that encode homologs of the Escherichia coli Bet and ProU systems for synthesis and transport, respectively, of glycine betaine, an osmoprotectant used during osmotic stress.	osmoprotectant	156-170	putative DNA recombination protein Bet	Escherichia coli	69-72
32261432-8	2014	Cyclooxygenase-2 (COX-2) inhibition by SC58236 revealed the up-regulation of this osmoprotectant molecule against the hyperosmotic activity of polymannitol, inducing rapid endocytosis of PMGT in order to re-balance the hyperosmotic environment.	osmoprotectant	82-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
32261432-8	2014	Cyclooxygenase-2 (COX-2) inhibition by SC58236 revealed the up-regulation of this osmoprotectant molecule against the hyperosmotic activity of polymannitol, inducing rapid endocytosis of PMGT in order to re-balance the hyperosmotic environment.	osmoprotectant	82-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
24808895-4	2014	One clone, SMG 9, was found to be positive for utilization/transport of L-carnitine (a well-characterized osmoprotectant) in the presence of 6% w/v sodium chloride (NaCl).	osmoprotectant	106-120	SMG9 nonsense mediated mRNA decay factor	Homo sapiens	11-16
20933050-1	2011	Betaine aldehyde dehydrogenase from the human opportunistic pathogen Pseudomonas aeruginosa (PaBADH) catalyzes the irreversible, NAD(P)(+)-dependent oxidation of betaine aldehyde, producing glycine betaine, an osmoprotectant.	osmoprotectant	210-224	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-30
9244277-0	1997	Osmoprotectant-dependent expression of plcH, encoding the hemolytic phospholipase C, is subject to novel catabolite repression control in Pseudomonas aeruginosa PAO1.	osmoprotectant	0-14	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	39-43
9244277-0	1997	Osmoprotectant-dependent expression of plcH, encoding the hemolytic phospholipase C, is subject to novel catabolite repression control in Pseudomonas aeruginosa PAO1.	osmoprotectant	0-14	phospholipase C	Pseudomonas aeruginosa PAO1	68-83
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	12-26	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	37-41
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	12-26	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	12-26	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	12-26	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	12-26	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	190-204	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	190-204	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	190-204	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-4	1997	Analyses of osmoprotectant-dependent plcH expression in a derivative of strain PAO1 containing a plcH::lacZ operon fusion showed that (i) succinate prevented induction of plcH expression by osmoprotectants; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-induced bacteria, while cultures supplemented with lactate had little or no change in plcH expression.	osmoprotectant	190-204	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-7	1997	Osmoprotectant-induced total PLC activities, levels of expression of plcH measured with the same plcH::lacZ fusion, and levels of plcH transcription in a CRC-deficient strain reflected those seen in strain PAO1.	osmoprotectant	0-14	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9244277-7	1997	Osmoprotectant-induced total PLC activities, levels of expression of plcH measured with the same plcH::lacZ fusion, and levels of plcH transcription in a CRC-deficient strain reflected those seen in strain PAO1.	osmoprotectant	0-14	hemolytic phospholipase C	Pseudomonas aeruginosa PAO1	97-101
9004219-0	1997	Molecular characterization of mutants affected in the osmoprotectant-dependent induction of phospholipase C in Pseudomonas aeruginosa PAO1.	osmoprotectant	54-68	phospholipase C	Pseudomonas aeruginosa PAO1	92-107