PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2684839-0	1989	Fasting plasma caffeine level in cirrhotic patients: relation to plasma levels of catecholamines and renin activity.	Caffeine	15-23	renin	Homo sapiens	101-106
2684839-10	1989	After abstinence from caffeine, the decrease of fasting plasma caffeine concentration correlated well with the decrease of plasma renin activity (r = +0.746, p less than 0.01).	Caffeine	22-30	renin	Homo sapiens	130-135
2684839-10	1989	After abstinence from caffeine, the decrease of fasting plasma caffeine concentration correlated well with the decrease of plasma renin activity (r = +0.746, p less than 0.01).	Caffeine	63-71	renin	Homo sapiens	130-135
2615045-6	1989	The response by muscles previously loaded with Ca2+ to a second application of caffeine was more greatly inhibited by both compounds (use-dependent effect).	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	47-50
2615045-7	1989	The inhibition of the contraction due to the first or second application of caffeine was greater when either agent was applied in Ca2+-containing medium than in Ca2(+)-free medium.	Caffeine	76-84	carbonic anhydrase 2	Rattus norvegicus	130-133
2615045-7	1989	The inhibition of the contraction due to the first or second application of caffeine was greater when either agent was applied in Ca2+-containing medium than in Ca2(+)-free medium.	Caffeine	76-84	carbonic anhydrase 2	Rattus norvegicus	161-164
2615045-8	1989	These results indicate that ryanodine and DH-ryanodine are similar in their effects on caffeine-induced Ca2+ release in vascular smooth muscle and that cellular Ca2+ levels may affect the action of ryanodine.	Caffeine	87-95	carbonic anhydrase 2	Rattus norvegicus	104-107
2677316-0	1989	Caffeine potentiates the renin response to furosemide in rats.	Caffeine	0-8	renin	Rattus norvegicus	25-30
2512932-5	1989	Both aminopyrine and caffeine demethylation, as measured by the amount of radiolabeled CO2 exhaled, also decreased with diminishing cytochrome P-450 content.	Caffeine	21-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	132-148
2510904-0	1989	Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain.	Caffeine	28-36	FBJ osteosarcoma oncogene	Mus musculus	45-50
2510904-1	1989	The adenosine receptor antagonist, caffeine, transiently induced proto-oncogene c-fos mRNA in mouse brain in a dose-dependent fashion.	Caffeine	35-43	FBJ osteosarcoma oncogene	Mus musculus	65-85
2510904-2	1989	In situ hybridization revealed that caffeine-induced c-fos expression was high in caudate-putamen and olfactory tubercle at both subconvulsive and convulsive doses.	Caffeine	36-44	FBJ osteosarcoma oncogene	Mus musculus	53-58
2510904-3	1989	The pattern of c-fos mRNA distribution following caffeine administration differs from that reported after seizures induced by electroconvulsive shock (ECS) or other chemical convulsants, and closely parallels the distribution of adenosine A2 receptors.	Caffeine	49-57	FBJ osteosarcoma oncogene	Mus musculus	15-20
2510904-4	1989	Furthermore, the potent adenosine A2 receptor agonist, 5"-N-ethylcarboxamide adenosine (NECA) blocked caffeine-induced c-fos expression whereas the adenosine A1 receptor ligand, N6-cyclohexyladenosine (CHA), had no effect.	Caffeine	102-110	FBJ osteosarcoma oncogene	Mus musculus	119-124
2510904-5	1989	This study suggests that the caffeine-induced expression of c-fos mRNA may be mediated by the adenosine A2 receptor in mouse brain.	Caffeine	29-37	FBJ osteosarcoma oncogene	Mus musculus	60-65
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	27-30
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	91-94
2613883-7	1989	The results reveal that caffeine- and Ca2+-induced oscillations in skeletal muscle fibres are triggered by a cyclic release of Ca2+ ions from the SR.	Caffeine	24-32	carbonic anhydrase 2	Homo sapiens	127-130
2677316-10	1989	Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure.	Caffeine	0-8	renin	Rattus norvegicus	87-92
2610366-5	1989	The relative standard deviations for 9.30 micrograms ml-1 of ascorbic acid, 8.50 micrograms ml-1 of caffeine and 7.30 micrograms ml-1 of paracetamol were 1.3, 2.5 and 0.7%, respectively.	Caffeine	100-108	interleukin 17F	Homo sapiens	92-96
2610366-5	1989	The relative standard deviations for 9.30 micrograms ml-1 of ascorbic acid, 8.50 micrograms ml-1 of caffeine and 7.30 micrograms ml-1 of paracetamol were 1.3, 2.5 and 0.7%, respectively.	Caffeine	100-108	interleukin 17F	Homo sapiens	92-96
2544298-2	1989	We cloned two independent genomic DNAs that complemented both the cold-sensitive and caffeine-hypersensitive phenotype of dis2-11.	Caffeine	85-93	type 1 serine/threonine-protein phosphatase catalytic subunit GLC7	Saccharomyces cerevisiae S288C	122-126
2760838-7	1989	Intravenous infusions of DPSPX attenuated and caffeine withdrawal potentiated AII-induced bradycardia without modifying AII-induced increases in arterial blood pressure.	Caffeine	46-54	angiotensinogen	Homo sapiens	78-81
2545192-2	1989	However, even in a Ca2+-free, EGTA-containing solution relatively high concentrations of ET1 induced a weak vasoconstriction, which was markedly but not completely inhibited by pretreatment with caffeine.	Caffeine	195-203	endothelin 1	Homo sapiens	89-92
2506065-7	1989	Similarly, the contracture induced by caffeine was not affected by lowering the external Ca2+ concentration to 10(-3) mM but was completely inhibited by 30 mM EGTA.	Caffeine	38-46	carbonic anhydrase 2	Mus musculus	89-92
2672065-4	1989	Surprisingly, our female subjects evidenced a small drop in SBP (1 mm Hg) and a decline in HR (5 bpm), and, as expected, they demonstrated a rise in DBP of 6 mm Hg in response to caffeine.	Caffeine	179-187	D-box binding PAR bZIP transcription factor	Homo sapiens	149-152
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	15-23	selenium binding protein 1	Homo sapiens	27-30
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	15-23	selenium binding protein 1	Homo sapiens	112-115
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	155-163	selenium binding protein 1	Homo sapiens	27-30
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	155-163	selenium binding protein 1	Homo sapiens	112-115
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	155-163	selenium binding protein 1	Homo sapiens	27-30
2672065-5	1989	The effects of caffeine on SBP and HR were contingent on the experimental condition such that the difference in SBP and HR between the high vs low dose of caffeine was significant only under the caffeine plus psychological stress condition.	Caffeine	155-163	selenium binding protein 1	Homo sapiens	112-115
2672065-7	1989	Previous evidence of significantly greater DBP pressor effects when caffeine is consumed under stressful conditions was confirmed.	Caffeine	68-76	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
2562274-5	1989	The inhibitory effect of caffeine on steady-state Ca2+ uptake was moderately abolished by the removal of endogenous CaM from SR vesicles.	Caffeine	25-33	calmodulin-2	Canis lupus familiaris	116-119
2735932-2	1989	The effects were potentiated in the presence of caffeine (CAF).	Caffeine	48-56	caffeine susceptibility	Mus musculus	58-61
2562274-7	1989	In summary, the data reveal that caffeine (1) inhibits oxalate entry pathway via inhibition of CaM, and (2) directly modifies CaM-dependent component of Ca2+ fluxes in the SR and reduces steady-state Ca2+ accumulation due to increased Ca2+ release through a Ca2+ efflux pathway which is inhibited by CaM but not due to reduced catalytic activity of the pump; and that the masseter muscle SR vesicles include IP3-sensitive Ca2+ release channel.	Caffeine	33-41	calmodulin-2	Canis lupus familiaris	95-98
2562274-7	1989	In summary, the data reveal that caffeine (1) inhibits oxalate entry pathway via inhibition of CaM, and (2) directly modifies CaM-dependent component of Ca2+ fluxes in the SR and reduces steady-state Ca2+ accumulation due to increased Ca2+ release through a Ca2+ efflux pathway which is inhibited by CaM but not due to reduced catalytic activity of the pump; and that the masseter muscle SR vesicles include IP3-sensitive Ca2+ release channel.	Caffeine	33-41	calmodulin-2	Canis lupus familiaris	126-129
2562274-7	1989	In summary, the data reveal that caffeine (1) inhibits oxalate entry pathway via inhibition of CaM, and (2) directly modifies CaM-dependent component of Ca2+ fluxes in the SR and reduces steady-state Ca2+ accumulation due to increased Ca2+ release through a Ca2+ efflux pathway which is inhibited by CaM but not due to reduced catalytic activity of the pump; and that the masseter muscle SR vesicles include IP3-sensitive Ca2+ release channel.	Caffeine	33-41	calmodulin-2	Canis lupus familiaris	126-129
2677641-5	1989	Caffeine and norepinephrine release Ca2+ from this store to induce a transient contraction.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	36-39
2539455-1	1989	CD-1 mice were treated with caffeine-sodium benzoate solution (caffeine doses: 0, 5, 15 or 30 mg/kg i.p.)	Caffeine	28-36	CD1 antigen complex	Mus musculus	0-4
2568423-4	1989	The effect on caffeine accumulation appears to be independent of the nature of the N3 substituent and its absence in rats given 1,3-disubstituted xanthines (1,3-DSX) instead of 1,3,8-TSX suggests that the presence of the C8-methyl group in the latter compounds is responsible for the accumulation phenomenon.	Caffeine	14-22	testis specific X-linked gene	Rattus norvegicus	183-186
2570368-1	1989	In a previous study we discovered that the adenosine receptor antagonist, caffeine, increases plasma renin activity and blood pressure in renin-dependent renovascular hypertension.	Caffeine	74-82	renin	Canis lupus familiaris	101-106
2570368-1	1989	In a previous study we discovered that the adenosine receptor antagonist, caffeine, increases plasma renin activity and blood pressure in renin-dependent renovascular hypertension.	Caffeine	74-82	renin	Canis lupus familiaris	138-143
2570368-3	1989	Accordingly, we examined the effects of infusions of caffeine and theophylline directly into the renal artery on the increase in renin secretion induced by suprarenal aortic constriction.	Caffeine	53-61	renin	Canis lupus familiaris	129-134
2570368-5	1989	Caffeine (5 mg/min) increased the renin response to suprarenal aortic constriction about 10-fold without significantly affecting renal hemodynamics or excretory function.	Caffeine	0-8	renin	Canis lupus familiaris	34-39
2923603-10	1989	Caffeine in concentration 12.5 mM, which did not displace Ca2 from guinea pig ventricular muscle, decreased Ca2 in the rabbit ventricle by 44%.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	108-111
2720727-1	1989	A nontoxic dose of caffeine enhanced the cytotoxicity of cisplatin in human osteosarcoma cells (OST strain).	Caffeine	19-27	MCF.2 cell line derived transforming sequence like	Homo sapiens	96-99
2730626-0	1989	Measurement of urinary caffeine metabolites reflecting the "in vivo" xanthine oxidase activity in premature infants with RDS and in hypoxic states of children.	Caffeine	23-31	peripherin 2	Homo sapiens	121-124
2653593-6	1989	Plasma insulin and norepinephrine were lower after caffeine ingestion, whereas an increase in plasma free fatty acids was noted.	Caffeine	51-59	insulin	Homo sapiens	7-14
2720727-2	1989	Synergistic cytotoxicity was seen in vitro in OST cells when 2 mmol caffeine was added to a nontoxic dose of cisplatin (2 micrograms/ml).	Caffeine	68-76	MCF.2 cell line derived transforming sequence like	Homo sapiens	46-49
2720727-3	1989	Caffeine reduced S-phase, G2/M-phase, and S-and-G2/M-phase accumulation by cisplatin on the DNA histogram, and nuclear fragmentation of tumor cells was frequently observed.	Caffeine	0-8	crystallin gamma E, pseudogene	Homo sapiens	42-50
2720727-5	1989	The antitumor effect of the combination of cisplatin and caffeine was examined in OST transplanted to BALB/C athymic mice.	Caffeine	57-65	mcf.2 transforming sequence-like	Mus musculus	82-85
3244386-4	1988	Caffeine (20 mmol/l) induced a large transient increase in [Ca2+]cyt followed by a plateau which was higher than resting level.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	60-63
2496962-0	1989	Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.	Caffeine	121-129	growth hormone 1	Homo sapiens	10-24
2496962-0	1989	Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.	Caffeine	121-129	growth hormone 1	Homo sapiens	36-50
2496962-0	1989	Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.	Caffeine	149-157	growth hormone 1	Homo sapiens	10-24
2496962-1	1989	In 6 growth hormone-deficient children, we have demonstrated that 3-N-demethylation of caffeine as measured by the 13CO2 caffeine breath test is decreased following 1 month of growth hormone therapy (8.4 +/- 1.0 vs. 6.8 +/- 1.2% 13C/2 h after treatment).	Caffeine	87-95	growth hormone 1	Homo sapiens	5-19
2496962-1	1989	In 6 growth hormone-deficient children, we have demonstrated that 3-N-demethylation of caffeine as measured by the 13CO2 caffeine breath test is decreased following 1 month of growth hormone therapy (8.4 +/- 1.0 vs. 6.8 +/- 1.2% 13C/2 h after treatment).	Caffeine	87-95	growth hormone 1	Homo sapiens	176-190
2496962-1	1989	In 6 growth hormone-deficient children, we have demonstrated that 3-N-demethylation of caffeine as measured by the 13CO2 caffeine breath test is decreased following 1 month of growth hormone therapy (8.4 +/- 1.0 vs. 6.8 +/- 1.2% 13C/2 h after treatment).	Caffeine	121-129	growth hormone 1	Homo sapiens	176-190
2848455-6	1988	Recordings of calcium ion currents through single channels showed that the Ca2+- and ATP-gated SR Ca2+ release channel is activated by addition of caffeine to the cis (cytoplasmic) and not the trans (lumenal) side of the channel in the bilayer.	Caffeine	147-155	carbonic anhydrase 2	Homo sapiens	75-118
3244386-0	1988	Multiple effects of caffeine on contraction and cytosolic free Ca2+ levels in vascular smooth muscle of rat aorta.	Caffeine	20-28	carbonic anhydrase 2	Rattus norvegicus	63-66
3244386-2	1988	Effects of caffeine on cytosolic Ca2+ level ([Ca2+]cyt), measured simultaneously with muscle tension using fura-2-Ca2+ fluorescence, were examined in isolated smooth muscle of rat aorta.	Caffeine	11-19	carbonic anhydrase 2	Rattus norvegicus	33-36
3217236-7	1988	After a wash in a Ca2+-free solution, a contraction due to a release of the accumulated Ca2+ could be induced by either 25 mM caffeine or 20 microM inositol 1,4,5-trisphosphate (InsP3) or 10 microM A23187.	Caffeine	126-134	carbonic anhydrase 2	Oryctolagus cuniculus	18-21
3217236-7	1988	After a wash in a Ca2+-free solution, a contraction due to a release of the accumulated Ca2+ could be induced by either 25 mM caffeine or 20 microM inositol 1,4,5-trisphosphate (InsP3) or 10 microM A23187.	Caffeine	126-134	carbonic anhydrase 2	Oryctolagus cuniculus	88-91
3244386-6	1988	In Ca2+-free solution, caffeine induced only a transient increase in both [Ca2+]cyt and muscle tension.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	3-6
3244386-6	1988	In Ca2+-free solution, caffeine induced only a transient increase in both [Ca2+]cyt and muscle tension.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	75-78
3244386-11	1988	During the sustained increase in [Ca2+]cyt induced by noradrenaline (10 mumol/l) or high K+ (140 mmol/l), addition of caffeine transiently increased [Ca2+]cyt followed by a decrease to a level slightly lower than that before the addition of caffeine.	Caffeine	118-126	carbonic anhydrase 2	Rattus norvegicus	34-37
3244386-11	1988	During the sustained increase in [Ca2+]cyt induced by noradrenaline (10 mumol/l) or high K+ (140 mmol/l), addition of caffeine transiently increased [Ca2+]cyt followed by a decrease to a level slightly lower than that before the addition of caffeine.	Caffeine	118-126	carbonic anhydrase 2	Rattus norvegicus	150-153
3244386-14	1988	These results suggest that caffeine-induced contraction is due to the release of Ca2+ from cellular store.	Caffeine	27-35	carbonic anhydrase 2	Rattus norvegicus	81-84
3244386-15	1988	Caffeine also has an inhibitory effect which is partly attributable to decrease in [Ca2+]cyt and partly to the decrease in the sensitivity to Ca2+ of the contractile elements.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	84-87
3244386-15	1988	Caffeine also has an inhibitory effect which is partly attributable to decrease in [Ca2+]cyt and partly to the decrease in the sensitivity to Ca2+ of the contractile elements.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	142-145
2462926-16	1988	The Ca2+-release channel studied using this method exhibits two predominant conductance levels (80-100 pS and 120-160 pS), conducts Ca2+ preferentially over K+ (PCa/Pk = 6.5), is highly voltage sensitive, blocked on one side by ruthenium red (1 microM), and displays enhanced activity in the presence of caffeine (5 mM).	Caffeine	304-312	ryanodine receptor 2	Oryctolagus cuniculus	4-24
3383374-4	1988	In the absence of extracellular Ca2+, caffeine and high extracellular K+ induced transient and dose-dependent elevations of the cytosolic Ca2+, and these elevations were not inhibited by either diltiazem or verapamil.	Caffeine	38-46	carbonic anhydrase 2	Rattus norvegicus	138-141
3191528-6	1988	The primary site of action of ATP in increasing Cai is at the sarcolemma since the addition to suspensions of myocytes of caffeine (10 mM), which depletes the sarcoplasmic reticulum Ca2+ load, does not prevent the subsequent increase of Cai due to ATP.	Caffeine	122-130	carbonic anhydrase 1	Rattus norvegicus	48-51
3406955-1	1988	Simultaneous administration of caffeine (100 mg/kg, i.p., 3 days) and phenobarbital (80 mg/kg, i.p., 3 days) to adult male rats resulted in a significant decrease in hepatic cytochrome P-450 and acetanilide hydroxylase activity, compared to phenobarbital administration alone.	Caffeine	31-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	174-190
3044993-2	1988	To further test this hypothesis, we compared the time course of caffeine-induced increases in plasma renin activity with the time course of changes in plasma levels of adenosine in two models of renin-dependent renovascular hypertension.	Caffeine	64-72	renin	Rattus norvegicus	101-106
3044993-6	1988	In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats.	Caffeine	38-46	renin	Rattus norvegicus	55-60
3044993-6	1988	In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats.	Caffeine	149-157	renin	Rattus norvegicus	55-60
3044993-7	1988	However, during the second and third weeks after clipping, caffeine had lesser effects on plasma renin activity.	Caffeine	59-67	renin	Rattus norvegicus	97-102
3044993-9	1988	Caffeine accelerated hypertension in 2K1C rats and rats with aortic ligation (renin-dependent renovascular hypertension), but it had no effect on plasma renin activity or blood pressure in one-kidney, one clip rats (renin-independent renovascular hypertension).	Caffeine	0-8	renin	Rattus norvegicus	78-83
3179612-12	1988	In a Ca2+-free solution, noradrenaline and caffeine induced a transient contraction in the aorta, whereas a second application of each stimulant was almost ineffective.	Caffeine	43-51	carbonic anhydrase 2	Oryctolagus cuniculus	5-8
3129507-11	1988	Moreover, a similar down-regulation of IL-2R expression was seen after stimulation with caffeine, theophylline, or dibutyryl cyclic AMP.	Caffeine	88-96	interleukin 2 receptor subunit alpha	Homo sapiens	39-44
3271620-6	1988	Pretreatment of MHS muscle with calmodulin-antagonist drugs potentiated its response to halothane and caffeine.	Caffeine	102-110	calmodulin-3	Sus scrofa	32-42
3363219-1	1988	Administration of caffeine (CAF) to mice as early as 6 hr prior to injection of a hepatotoxic but nonlethal dose of acetaminophen (ACM) significantly antagonized the hepatotoxic action of ACM as judged by serum levels of alanine aminotransferase (ALT) activity.	Caffeine	18-26	caffeine susceptibility	Mus musculus	28-31
3356110-4	1988	In the control group, the mean (+/- SD) serum caffeine clearance was 1.3 +/- 0.4 ml min-1 kg-1 and a mean of 56.4 +/- 16.5% of the administered caffeine was recovered from the urine over 48 h as methyluric acids and methylxanthines.	Caffeine	46-54	CD59 molecule (CD59 blood group)	Homo sapiens	84-94
3356110-8	1988	Thus the mean serum caffeine clearance was 1.4 +/- 1.2 ml min-1 kg-1 and a mean of 57.2 +/- 11.7% of the administered caffeine was recovered from the urine over 48 h. The majority of the metabolites were excreted in the first 24 h; the pattern of metabolic excretion was unaltered and only 2.2 +/- 0.9% of the administered caffeine was excreted unchanged.	Caffeine	20-28	CD59 molecule (CD59 blood group)	Homo sapiens	58-68
3356110-11	1988	The mean serum caffeine clearance (0.4 +/- 0.2 ml min-1 kg-1) was significantly impaired compared with controls (P less than 0.01) and a significant delay was observed in metabolite excretion in the urine.	Caffeine	15-23	CD59 molecule (CD59 blood group)	Homo sapiens	50-60
2899631-10	1988	+/- 2.3 (n = 5) tension (Tp2) increased significantly (P less than or equal to 0.05) in the presence of caffeine (4.1 x 10(-3) M).	Caffeine	104-112	transition protein 2	Rattus norvegicus	25-28
3355603-0	1988	Study of deutero-isotopomer-induced inhibition of caffeine and phenobarbitone binding to human serum albumin.	Caffeine	50-58	albumin	Homo sapiens	95-108
3363219-1	1988	Administration of caffeine (CAF) to mice as early as 6 hr prior to injection of a hepatotoxic but nonlethal dose of acetaminophen (ACM) significantly antagonized the hepatotoxic action of ACM as judged by serum levels of alanine aminotransferase (ALT) activity.	Caffeine	18-26	glutamic pyruvic transaminase, soluble	Mus musculus	221-245
3363219-1	1988	Administration of caffeine (CAF) to mice as early as 6 hr prior to injection of a hepatotoxic but nonlethal dose of acetaminophen (ACM) significantly antagonized the hepatotoxic action of ACM as judged by serum levels of alanine aminotransferase (ALT) activity.	Caffeine	18-26	glutamic pyruvic transaminase, soluble	Mus musculus	247-250
3359242-1	1988	Caffeine (50 microM) increases the amplitude of the basal field potential (BFP) due to orthodromic stimulation of CA1 pyramidal neurons in rat hippocampal slices.	Caffeine	0-8	carbonic anhydrase 1	Rattus norvegicus	114-117
3337818-2	1988	The transient calcium-, caffeine- and AMP-induced calcium release from actively loaded sarcoplasmic reticulum vesicles was reduced to 29%, 51% and 59% of the respective control value by 1 microM exogenous calmodulin.	Caffeine	24-32	calmodulin	Oryctolagus cuniculus	205-215
2977050-2	1988	Plasma beta-thromboglobulin concentration was determined before and one hour after administration of 100 mg of caffeine, corresponding to one cup of coffee.	Caffeine	111-119	pro-platelet basic protein	Homo sapiens	7-27
3337818-3	1988	Stopped-flow measurements demonstrate that calmodulin reduces the apparent rate of caffeine-induced calcium release from actively loaded sarcoplasmic reticulum.	Caffeine	83-91	calmodulin	Oryctolagus cuniculus	43-53
3337818-5	1988	The rate of the calcium-, caffeine- and AMP-induced calcium release from passively loaded sarcoplasmic reticulum vesicles was reduced 1.4-2.0-fold by 1 microM exogenous calmodulin, i.e. the half-time of release was maximally increased by a factor of two, whilst calmodulin-dependent phosphorylation of a 57 kDa protein with ATP[S] had no effect.	Caffeine	26-34	calmodulin	Oryctolagus cuniculus	169-179
3337818-5	1988	The rate of the calcium-, caffeine- and AMP-induced calcium release from passively loaded sarcoplasmic reticulum vesicles was reduced 1.4-2.0-fold by 1 microM exogenous calmodulin, i.e. the half-time of release was maximally increased by a factor of two, whilst calmodulin-dependent phosphorylation of a 57 kDa protein with ATP[S] had no effect.	Caffeine	26-34	calmodulin	Oryctolagus cuniculus	262-272
3350771-2	1988	The application of caffeine, which causes contractures in skeletal and smooth muscle by releasing calcium from intracellular stores to activate actin and myosin interaction, also causes shortening of OHCs.	Caffeine	19-27	myosin heavy chain 14	Homo sapiens	154-160
3690322-2	1987	Both theophylline and caffeine induced the generation of epileptiform activity in the CA3 region of the hippocampal slice with convulsive dose50 (CD50) values of 3 microM respectively.	Caffeine	22-30	carbonic anhydrase 3	Rattus norvegicus	86-89
3406045-4	1988	Lipolysis in adipocytes induced by adenosine deaminase (1 U/ml) decreased by 35% in caffeine-treated rats.	Caffeine	84-92	adenosine deaminase	Rattus norvegicus	35-54
3690324-1	1987	The effects of caffeine were investigated on the extracellular excitatory postsynaptic potentials (EPSPs) recorded in the stratum radiatum of CA1 of the rat hippocampal slice in response to stimulation of the Schaffer collaterals.	Caffeine	15-23	carbonic anhydrase 1	Rattus norvegicus	142-145
2823418-11	1987	Addition of dibutyryl cAMP (0.1 mM) or caffeine (1.0 mM) to freshly plated cultures elevated cAMP levels 50-fold and twofold, respectively.	Caffeine	39-47	cathelicidin antimicrobial peptide	Mus musculus	93-97
3432046-6	1987	3,4-DAP increased the caffeine contracture tension (2.5-10 mM) and lowered the caffeine contracture threshold.	Caffeine	22-30	death-associated protein	Rattus norvegicus	4-7
3432046-6	1987	3,4-DAP increased the caffeine contracture tension (2.5-10 mM) and lowered the caffeine contracture threshold.	Caffeine	79-87	death-associated protein	Rattus norvegicus	4-7
3681903-4	1987	Our results suggest that the inhibition of DNA repair, including the inhibition in G2 phase, plays an important role in the expression of FRA3B, supporting other authors" data on the effect of other DNA repair inhibitors, such as aphidicolin, caffeine, 1-beta-D-arabinofuranosylcytosine, and 5-fluorodeoxyuridine, on the expression of FRA3B.	Caffeine	243-251	fragile histidine triad diadenosine triphosphatase	Homo sapiens	138-143
2959345-7	1987	4 In Ca2+-free, EGTA-containing solutions, both ACh, NA and caffeine produced transient contractions, the amplitude of which could be taken as a measurement of the amount of internal calcium present in a drug-sensitive calcium store.	Caffeine	60-68	carbonic anhydrase 2	Rattus norvegicus	5-8
2446131-6	1987	Since caffeine enhances the release of Ca2+ from terminal cisternae, it is postulated that the accelerated fatigue in the presence of caffeine is indicative of a reduced availability of Ca2+ for release.	Caffeine	6-14	carbonic anhydrase 2	Rattus norvegicus	39-42
2446131-6	1987	Since caffeine enhances the release of Ca2+ from terminal cisternae, it is postulated that the accelerated fatigue in the presence of caffeine is indicative of a reduced availability of Ca2+ for release.	Caffeine	134-142	carbonic anhydrase 2	Rattus norvegicus	39-42
3631312-0	1987	Use of caffeine to lengthen seizures in ECT.	Caffeine	7-15	ECT	Homo sapiens	40-43
3301987-5	1987	Caffeine administered acutely to non-users or recent abstainers can induce hypertension, arrhythmias, altered myocardial function, increased plasma catecholamine levels, plasma renin activity, serum cholesterol levels, increased production of urine, gastric acid secretion, and alterations in mood and sleep patterns.	Caffeine	0-8	renin	Homo sapiens	177-182
3659572-1	1987	Coadministration of caffeine (CAF) with acetaminophen (ACM) to mice prolonged the blood half-life of ACM, increased moderately the fraction of ACM excreted as the glucuronide conjugate, and decreased slightly the fraction excreted as the sulfate conjugate.	Caffeine	20-28	caffeine susceptibility	Mus musculus	30-33
3665987-3	1987	In the caffeine-treated groups, HAN appeared at 60, 120, 60 and 90 days of age in SHN, SLN, GR/A and C3H/He, respectively, while no such changes developed in the controls at the respective ages.	Caffeine	7-15	sarcolipin	Mus musculus	87-90
3110209-0	1987	Caffeine enhances the slow-pressor response to angiotensin II in rats.	Caffeine	0-8	angiotensinogen	Rattus norvegicus	47-61
3110209-2	1987	The purpose of this study was to determine if caffeine augments the slow-pressor response to chronic low-dose infusions of angiotensin II (AII) or the rapid-pressor response to acute infusions of AII.	Caffeine	46-54	angiotensinogen	Rattus norvegicus	123-137
3110209-6	1987	Caffeine greatly augmented this slow-pressor response to AII in intact animals; however, caffeine failed to enhance AII-induced hypertension in sympathectomized rats.	Caffeine	0-8	angiotensinogen	Rattus norvegicus	57-60
3110209-8	1987	We conclude that caffeine augmented the slow-pressor effect of chronic low-dose infusions of AII via a mechanism that involved the sympathetic nervous system.	Caffeine	17-25	angiotensinogen	Rattus norvegicus	93-96
2434495-8	1987	These results suggest that cardiac sarcoplasmic reticulum contains a ligand-gated Ca2+ channel which is activated by Ca2+, adenine nucleotide, and caffeine, and inhibited by Mg2+, H+, and calmodulin.	Caffeine	147-155	calmodulin-2	Canis lupus familiaris	188-198
3106796-8	1987	MS 1, which is hypersensitive to MMS and caffeine, but not sensitive to UV or 4NQO, responded to caffeine with an enhanced frequency of SCEs and had a normal frequency of MMS-induced SCEs, but a reduced frequency of UV- and 4NQO-induced SCEs.	Caffeine	41-49	muscle size 1	Mus musculus	0-4
3106796-8	1987	MS 1, which is hypersensitive to MMS and caffeine, but not sensitive to UV or 4NQO, responded to caffeine with an enhanced frequency of SCEs and had a normal frequency of MMS-induced SCEs, but a reduced frequency of UV- and 4NQO-induced SCEs.	Caffeine	97-105	muscle size 1	Mus musculus	0-4
3609156-4	1987	The activities of ChE fractions of dogs (C3), miniature pigs (C1, C2), rabbits (C1), and hamsters (C3) were inhibited by 6.1 X 10(-2)M caffein but not by 10(-4)M ethopropazine, which suggests that the fractions are all true-ChE.	Caffeine	135-142	cholinesterase	Oryctolagus cuniculus	18-21
3109763-3	1987	Infusion of 1 mM caffeine inhibited PG output elicited by AVP, AII, and NE but not that caused by BK in the absence of extracellular Ca2+.	Caffeine	17-25	angiotensinogen	Rattus norvegicus	63-66
2437804-5	1987	Fourth, prostaglandin E1 and the inhibitors of the cyclic nucleotide phosphodiesterases, 3-isobutyl-1-methylxanthine, theophylline, and caffeine, all increased both cellular cAMP and cGMP concentration but had no effect on 2-DG uptake.	Caffeine	136-144	cathelicidin antimicrobial peptide	Rattus norvegicus	174-178
3671445-2	1987	From the elimination velocity of these model substances conclusions concerning the activity of 3-methylcholanthrene (caffeine elimination) and phenobarbital inducible isoenzymes (metamizol elimination) of cytochrome P-450 are drawn.	Caffeine	117-125	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	205-221
3593412-2	1987	The nature of the cytochrome P-450-dependent enzyme reactions giving rise to four primary metabolites of caffeine was investigated using microsomes isolated from livers of human kidney donors.	Caffeine	105-113	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-34
3593412-5	1987	7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds.	Caffeine	245-253	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	124-140
3593412-5	1987	7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds.	Caffeine	299-307	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	124-140
3593412-8	1987	Taken together, the data support suggestions from in vivo studies that a PAH-inducible isozyme of cytochrome P-450 plays a significant role in the biotransformation of caffeine in man.	Caffeine	168-176	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-114
2882985-0	1987	Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes.	Caffeine	21-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	134-139
2882985-10	1987	Taken together, the data provide a rationale for a potential in vivo marker of polycyclic aromatic hydrocarbon-inducible cytochrome P-450 activity based on a urinary metabolite ratio of paraxanthine 7-demethylation to 8-hydroxylation products after caffeine intake.	Caffeine	249-257	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	132-137
3823609-1	1987	Studies of interactions in mice between acetaminophen (ACM) and caffeine (CAF) revealed that CAF given immediately after ACM antagonized the acute toxicity of ACM and reduced the severity of ACM-induced hepatic necrosis as assessed grossly and microscopically.	Caffeine	64-72	caffeine susceptibility	Mus musculus	74-77
3032652-7	1987	The conclusion that c-AMP produced these effects by stimulating Ca uptake into the superficial SR was supported by the finding that dB-c-AMP increased the amount of Ca taken up into a caffeine releasable fraction.	Caffeine	184-192	antimicrobial protein CAP18	Oryctolagus cuniculus	20-25
3032652-7	1987	The conclusion that c-AMP produced these effects by stimulating Ca uptake into the superficial SR was supported by the finding that dB-c-AMP increased the amount of Ca taken up into a caffeine releasable fraction.	Caffeine	184-192	antimicrobial protein CAP18	Oryctolagus cuniculus	135-140
3558581-5	1987	Caffeine was extracted from diluted serum and saliva samples (10-500 microliter) by adsorption on a small Bond-Elut C18 cartridge and recovered by elution with methanol.	Caffeine	0-8	Bardet-Biedl syndrome 9	Homo sapiens	116-119
3823609-1	1987	Studies of interactions in mice between acetaminophen (ACM) and caffeine (CAF) revealed that CAF given immediately after ACM antagonized the acute toxicity of ACM and reduced the severity of ACM-induced hepatic necrosis as assessed grossly and microscopically.	Caffeine	64-72	caffeine susceptibility	Mus musculus	93-96
3475476-6	1987	A significant decrease in 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity, and consequent reduction in testosterone biosynthesis, in the fetal testes at d 18 and 20 of gestation was also found for both doses of caffeine.	Caffeine	221-229	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	63-73
2882901-3	1987	The Ca2+ release was enhanced by caffeine and adenine, and suppressed by Mg2+ and procaine.	Caffeine	33-41	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	4-7
3111805-1	1987	Caffeine has been shown to markedly alter growth hormone (GH), thyroid stimulating hormone (TSH), and thyroid hormones in animal studies.	Caffeine	0-8	growth hormone 1	Homo sapiens	42-56
3111805-1	1987	Caffeine has been shown to markedly alter growth hormone (GH), thyroid stimulating hormone (TSH), and thyroid hormones in animal studies.	Caffeine	0-8	growth hormone 1	Homo sapiens	58-60
3432293-4	1987	In contrast, a reduction of AChR levels occurs due to prolonged treatment with caffeine or carbamylcholine.	Caffeine	79-87	cholinergic receptor nicotinic delta subunit	Gallus gallus	28-32
27456801-2	1986	This analysis of caffeine, endurance, and cholesterol considers whether and how caffeine is an ergogenic aid.	Caffeine	80-88	activation induced cytidine deaminase	Homo sapiens	105-108
2430628-1	1986	Relation between the Ca2+ release caused by Ca2+ ions and caffeine].	Caffeine	58-66	carbonic anhydrase 2	Homo sapiens	21-24
3756902-1	1986	1,3,7-Trimethylxanthine "caffeine" (CAF) is reported to induce a differential effect on the cytotoxicity of the DNA intercalators actinomycin-D versus Adriamycin (ADR).	Caffeine	0-23	caffeine susceptibility	Mus musculus	36-39
3756902-1	1986	1,3,7-Trimethylxanthine "caffeine" (CAF) is reported to induce a differential effect on the cytotoxicity of the DNA intercalators actinomycin-D versus Adriamycin (ADR).	Caffeine	25-34	caffeine susceptibility	Mus musculus	36-39
3779883-5	1986	The incidence of DNA breaks was markedly potentiated in the presence of non-toxic concentration of caffeine (CAF), used to inhibit DNA repair.	Caffeine	99-107	caffeine susceptibility	Mus musculus	109-112
2430628-2	1986	Using a Ca2+-selective electrode and Quin 2 and chlortetracycline fluorescence, a Ca2+ release from terminal cysterns of skeletal muscle sarcoplasmic reticulum under effects of heparin, caffeine and Ca2+ has been studied.	Caffeine	186-194	carbonic anhydrase 2	Homo sapiens	82-85
2430628-2	1986	Using a Ca2+-selective electrode and Quin 2 and chlortetracycline fluorescence, a Ca2+ release from terminal cysterns of skeletal muscle sarcoplasmic reticulum under effects of heparin, caffeine and Ca2+ has been studied.	Caffeine	186-194	carbonic anhydrase 2	Homo sapiens	82-85
2430628-4	1986	Preliminary release of Ca2+ in the presence of caffeine, which activates Mg2+-dependent Ca2+ release, does not prevent the heparin-induced Ca2+ release.	Caffeine	47-55	carbonic anhydrase 2	Homo sapiens	23-26
2430628-4	1986	Preliminary release of Ca2+ in the presence of caffeine, which activates Mg2+-dependent Ca2+ release, does not prevent the heparin-induced Ca2+ release.	Caffeine	47-55	carbonic anhydrase 2	Homo sapiens	88-91
2430628-4	1986	Preliminary release of Ca2+ in the presence of caffeine, which activates Mg2+-dependent Ca2+ release, does not prevent the heparin-induced Ca2+ release.	Caffeine	47-55	carbonic anhydrase 2	Homo sapiens	88-91
2430628-8	1986	The data obtained suggest that sarcoplasmic reticulum terminal cysterns contain two systems of Ca2+-induced release of Ca2+, i.e., a Mg2+-dependent, caffeine-sensitive and a Mg2+-independent heparin-sensitive ones.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	95-98
2430628-8	1986	The data obtained suggest that sarcoplasmic reticulum terminal cysterns contain two systems of Ca2+-induced release of Ca2+, i.e., a Mg2+-dependent, caffeine-sensitive and a Mg2+-independent heparin-sensitive ones.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	119-122
2430628-9	1986	The mechanism of activation of both systems by caffeine and heparin consists, in all probability, in their increased affinity for Ca2+.	Caffeine	47-55	carbonic anhydrase 2	Homo sapiens	130-133
2430628-1	1986	Relation between the Ca2+ release caused by Ca2+ ions and caffeine].	Caffeine	58-66	carbonic anhydrase 2	Homo sapiens	44-47
3017491-8	1986	In rats drinking tap water, caffeine added to the superfusion fluid at a concentration of 50 microM enhanced ACh release, while at 0.5 mM it decreased ACh output from the slices.	Caffeine	28-36	nuclear RNA export factor 1	Rattus norvegicus	17-20
3714371-6	1986	Episodes of GER increased significantly (P less than .001) in about 50% of the group treated with caffeine and in 66% of the group treated with theophylline.	Caffeine	98-106	GER	Homo sapiens	12-15
3503542-4	1986	In contrast, the serum PTH and 1,25(OH)2D remained unchanged initially, but increased after 2 weeks of caffeine administration.	Caffeine	103-111	parathyroid hormone	Rattus norvegicus	23-26
3503542-7	1986	In the adult rat group, an increase in the urinary calcium and endogenous fecal calcium excretion and serum levels of PTH was found after caffeine administration.	Caffeine	138-146	parathyroid hormone	Rattus norvegicus	118-121
3702903-3	1986	Hydrogen peroxide (H2O2) and caffeine were examined for their capacity for inducing SCEs and mutations at the HPRT locus in V79 Chinese hamster cells.	Caffeine	29-37	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	110-114
3084068-3	1986	Tumor cell lethality was increased up to 10-fold by either caffeine or pentoxifylline (1 mM) present during the first cell cycle (16-24 h) after exposure to nitrogen mustard (HN2) or thiotepa.	Caffeine	59-67	MT-RNR2 like 2 (pseudogene)	Homo sapiens	175-178
3714371-8	1986	In addition, an increase was noted for the number of episodes of GER in 24 hours (from 5.3 to 17.1 in the caffeine group and from 5.3 to 24.3 in the theophylline group) and for the time pH was less than 4 (from 0.87% to 6% in the caffeine group and up to 13% in the theophylline group).	Caffeine	106-114	GER	Homo sapiens	65-68
3714371-8	1986	In addition, an increase was noted for the number of episodes of GER in 24 hours (from 5.3 to 17.1 in the caffeine group and from 5.3 to 24.3 in the theophylline group) and for the time pH was less than 4 (from 0.87% to 6% in the caffeine group and up to 13% in the theophylline group).	Caffeine	230-238	GER	Homo sapiens	65-68
2423142-0	1986	[Release of Ca2+ ions from the sarcoplasmic reticulum of skeletal muscles after treatment with caffeine].	Caffeine	95-103	carbonic anhydrase 2	Oryctolagus cuniculus	12-15
2423142-2	1986	It was shown that the caffeine-induced release of Ca2+ depends on Ca2+ and Mg2+ concentration in the medium; Mg2+ inhibit, while Ca2+ stimulate this process.	Caffeine	22-30	carbonic anhydrase 2	Oryctolagus cuniculus	50-53
2423142-2	1986	It was shown that the caffeine-induced release of Ca2+ depends on Ca2+ and Mg2+ concentration in the medium; Mg2+ inhibit, while Ca2+ stimulate this process.	Caffeine	22-30	carbonic anhydrase 2	Oryctolagus cuniculus	66-69
2423142-2	1986	It was shown that the caffeine-induced release of Ca2+ depends on Ca2+ and Mg2+ concentration in the medium; Mg2+ inhibit, while Ca2+ stimulate this process.	Caffeine	22-30	carbonic anhydrase 2	Oryctolagus cuniculus	66-69
2423142-3	1986	The caffeine-induced transport of Ca2+ is blocked by ruthenium red, tetracaine and dimethylsulfoxide.	Caffeine	4-12	carbonic anhydrase 2	Oryctolagus cuniculus	34-37
2423142-4	1986	The Ca2+ release induced by Ca2+ was shown to occur in two ways, i. e., via Mg2+-dependent (inhibited by Mg2+ and caffeine blockers) and Mg2+-independent (insensitive to caffeine inhibitors, including Mg2+) routes.	Caffeine	114-122	carbonic anhydrase 2	Oryctolagus cuniculus	4-7
2423142-4	1986	The Ca2+ release induced by Ca2+ was shown to occur in two ways, i. e., via Mg2+-dependent (inhibited by Mg2+ and caffeine blockers) and Mg2+-independent (insensitive to caffeine inhibitors, including Mg2+) routes.	Caffeine	114-122	carbonic anhydrase 2	Oryctolagus cuniculus	28-31
2423142-4	1986	The Ca2+ release induced by Ca2+ was shown to occur in two ways, i. e., via Mg2+-dependent (inhibited by Mg2+ and caffeine blockers) and Mg2+-independent (insensitive to caffeine inhibitors, including Mg2+) routes.	Caffeine	170-178	carbonic anhydrase 2	Oryctolagus cuniculus	4-7
2423142-4	1986	The Ca2+ release induced by Ca2+ was shown to occur in two ways, i. e., via Mg2+-dependent (inhibited by Mg2+ and caffeine blockers) and Mg2+-independent (insensitive to caffeine inhibitors, including Mg2+) routes.	Caffeine	170-178	carbonic anhydrase 2	Oryctolagus cuniculus	28-31
2423142-5	1986	It was assumed that caffeine stimulates the Mg2+-dependent, Ca2+-induced release of Ca2+.	Caffeine	20-28	carbonic anhydrase 2	Oryctolagus cuniculus	60-63
2423142-5	1986	It was assumed that caffeine stimulates the Mg2+-dependent, Ca2+-induced release of Ca2+.	Caffeine	20-28	carbonic anhydrase 2	Oryctolagus cuniculus	84-87
2423142-6	1986	The sensitivity of Ca2+ transport to caffeine testifies to the fact that about 80% of the total Ca2+ transport activity of fast skeletal muscle homogenates belongs to terminal cisterns.	Caffeine	37-45	carbonic anhydrase 2	Oryctolagus cuniculus	19-22
2423142-6	1986	The sensitivity of Ca2+ transport to caffeine testifies to the fact that about 80% of the total Ca2+ transport activity of fast skeletal muscle homogenates belongs to terminal cisterns.	Caffeine	37-45	carbonic anhydrase 2	Oryctolagus cuniculus	96-99
3714044-5	1986	We have chosen caffeine because of its well established effect of releasing Ca2+ from smooth endoplasmic reticulum in muscle.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	76-79
3745848-2	1986	After 10 healthy volunteers drank 50 ml of coffee solution corresponding to one cup of home-made regular coffee containing 10 g of sugar and 240 mg/100 ml of caffeine, serum total gastrin levels peaked at 10 min and returned to basal values within 30 min; the response was of little significance (1.24 times the median basal value).	Caffeine	158-166	gastrin	Homo sapiens	180-187
3714044-10	1986	We conclude that caffeine causes the release of Ca2+ from a non-mitochondrial store within the growth cone and that this Ca2+ store supports that component of the K+-induced release of [3H]gamma-aminobutyric acid that is independent of extracellular Ca2+.	Caffeine	17-25	carbonic anhydrase 2	Rattus norvegicus	48-51
2874933-6	1986	Caffeine releases Ca2+ from the cellular high affinity binding sites.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	18-21
2937299-5	1986	Using a thymidylate synthase deficient hybrid which could be blocked in the S phase by thymidine deprivation, we found that caffeine significantly reduced the recovery time from thymidine release to mitosis.	Caffeine	124-132	thymidylate synthase	Cricetulus griseus	8-28
2868968-7	1986	Ethanol increases the minor effect of 50 mg/kg caffeine on TAT induction markedly.	Caffeine	47-55	tyrosine aminotransferase	Rattus norvegicus	59-62
2868968-10	1986	A combination of nicotinamide with orotic acid or with caffeine leads to substances with a higher effect on TAT induction.	Caffeine	55-63	tyrosine aminotransferase	Rattus norvegicus	108-111
2868968-0	1986	Influence of ethanol, nicotinamide, orotic acid and caffeine upon the induction of tyrosine aminotransferase, the NAD content and the ADPR transferase activity in rat liver.	Caffeine	52-60	tyrosine aminotransferase	Rattus norvegicus	83-108
4095132-2	1985	That"s why the half life of caffeine and the elimination of the main metabolites of metamizol were used as parameters in vivo characterizing both groups of the cytochrome P-450-complex.	Caffeine	28-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	160-176
4095131-0	1985	[Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans].	Caffeine	16-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-86
2866770-8	1985	The phosphodiesterase inhibitors (theophylline and caffeine) were able to induce de novo PRP biosynthesis at drug doses of 20 mg/200 g animal.	Caffeine	51-59	proline rich protein 2-like 1	Rattus norvegicus	89-92
2866001-4	1985	SS also decreased the amplitude and maximum rate of depolarization of the slow action potential as well as the amplitude of the slow contractions induced by isoprenaline and caffeine in K-depolarized atrial fibres.	Caffeine	174-182	somatostatin	Cavia porcellus	0-2
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	215-223	carbonic anhydrase 2	Homo sapiens	176-179
4071684-0	1985	[Effect of caffeine on kinetics of accumulation and release of Ca2+ by vesicles of the sarcoplasmic reticulum of skeletal muscle].	Caffeine	11-19	carbonic anhydrase 2	Homo sapiens	63-66
4095132-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	76-81
4095132-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81
4095132-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	214-221
4071684-2	1985	Caffeine lowers the ATP-dependent accumulation of Ca2+ by vesicles and enhances the first rapid phase of the Ci2+ release from vesicles.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	50-53
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	215-223	carbonic anhydrase 2	Homo sapiens	176-179
4071684-3	1985	The action of caffeine was transient, reversed, Ca2+-dependent.	Caffeine	14-22	carbonic anhydrase 2	Homo sapiens	48-51
4027366-0	1985	[Effect of caffeine on active Ca2+ ion transport in a homogenate of skeletal muscles and myocardium].	Caffeine	11-19	carbonic anhydrase 2	Oryctolagus cuniculus	30-33
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	121-129	carbonic anhydrase 2	Homo sapiens	163-166
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	121-129	carbonic anhydrase 2	Homo sapiens	176-179
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	121-129	carbonic anhydrase 2	Homo sapiens	176-179
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	121-129	carbonic anhydrase 2	Homo sapiens	176-179
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	215-223	carbonic anhydrase 2	Homo sapiens	163-166
4071684-4	1985	The data obtained suggest that the reduction of ATP-dependent calcium accumulation and enhancement of calcium release by caffeine are mediated by the mechanism of Ca2+-induced Ca2+ release and support the view that caffeine may regulate the equilibrium between open and closed states of Ca2+-channel by increasing the affinity of Ca2+-receptor site of the channel.	Caffeine	215-223	carbonic anhydrase 2	Homo sapiens	176-179
3001551-7	1985	On the other hand, perinatal caffeine effects are certainly not mediated by blockade of phosphodiesterases, since cAMP levels at the end of the treatment were dose-dependently reduced.	Caffeine	29-37	cathelicidin antimicrobial peptide	Rattus norvegicus	114-118
2992292-2	1985	Increased concentrations of VIP (over 10(-9) M) inhibited the contractions induced by caffeine and 39 mM [K]o.	Caffeine	86-94	VIP peptides	Oryctolagus cuniculus	28-31
2412614-0	1985	[Effect of caffeine on the Ca2+-transport function of sarcoplasmic reticulum vesicles in the rat myocardium].	Caffeine	11-19	carbonic anhydrase 2	Rattus norvegicus	27-30
2412614-1	1985	The effects of caffeine on active transport of Ca2 by heavy and light fractions of rat myocardial microsomes were investigated with the use of a Ca2+-selective electrode and nephelometry.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	47-50
2412614-2	1985	It was found that under the effect of caffeine (5 mM) the rate of Ca2 transport in the presence of oxalate decreased by 30 to 40%.	Caffeine	38-46	carbonic anhydrase 2	Rattus norvegicus	66-69
2412614-4	1985	Since caffeine is a specific blocker of Ca2 transport to the terminal cisterns of the skeletal muscle sarcoplasmic reticulum, it is assumed that the microsomal fraction of rat myocardium contains terminal cistern fragments.	Caffeine	6-14	carbonic anhydrase 2	Rattus norvegicus	40-43
4027366-3	1985	Caffeine (5 mM) exerts a powerful inhibitory influence on Ca2+ transport in skeletal muscle homogenates.	Caffeine	0-8	carbonic anhydrase 2	Oryctolagus cuniculus	58-61
4027366-7	1985	The high sensitivity of Ca2 transport to caffeine, a specific blocker of Ca2+ transport to the terminal cisterns of the sarcoplasmic reticulum, suggests that the terminal cisterns, apart from being a reservoir for Ca2+ needed for contraction trigger, may play an essential role in muscle relaxation.	Caffeine	41-49	carbonic anhydrase 2	Oryctolagus cuniculus	24-27
4027366-7	1985	The high sensitivity of Ca2 transport to caffeine, a specific blocker of Ca2+ transport to the terminal cisterns of the sarcoplasmic reticulum, suggests that the terminal cisterns, apart from being a reservoir for Ca2+ needed for contraction trigger, may play an essential role in muscle relaxation.	Caffeine	41-49	carbonic anhydrase 2	Oryctolagus cuniculus	73-76
4027366-7	1985	The high sensitivity of Ca2 transport to caffeine, a specific blocker of Ca2+ transport to the terminal cisterns of the sarcoplasmic reticulum, suggests that the terminal cisterns, apart from being a reservoir for Ca2+ needed for contraction trigger, may play an essential role in muscle relaxation.	Caffeine	41-49	carbonic anhydrase 2	Oryctolagus cuniculus	73-76
3875711-12	1985	A low concentration of caffeine elevates cytoplasmic resting Ca2+ level without tension development.	Caffeine	23-31	carbonic anhydrase 2	Homo sapiens	61-64
4044104-9	1985	However, in using a 2 mM lactate level as a criterion, the LT during the caffeine trial (2.13 +/- 0.22 l X min-1) was significantly (P less than 0.05) lower than during the control trial (2.71 +/- 0.17 l X min-1).	Caffeine	73-81	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
4044104-9	1985	However, in using a 2 mM lactate level as a criterion, the LT during the caffeine trial (2.13 +/- 0.22 l X min-1) was significantly (P less than 0.05) lower than during the control trial (2.71 +/- 0.17 l X min-1).	Caffeine	73-81	CD59 molecule (CD59 blood group)	Homo sapiens	206-211
3925951-3	1985	However, the concentration of the cytosolic Ca2+ was not elevated when the intracellularly stored Ca2+ was depleted by the repetitive treatment with caffeine prior to the application of high K+.	Caffeine	149-157	carbonic anhydrase 2	Rattus norvegicus	44-47
2415953-3	1985	Isobutyl-methylxanthine (IBMX), caffeine, and forskolin augmented the release of ACTH induced from CRF 1.0 nM by 17%, 39%, and 20%, respectively.	Caffeine	32-40	corticotropin releasing hormone receptor 1	Rattus norvegicus	99-104
3925951-3	1985	However, the concentration of the cytosolic Ca2+ was not elevated when the intracellularly stored Ca2+ was depleted by the repetitive treatment with caffeine prior to the application of high K+.	Caffeine	149-157	carbonic anhydrase 2	Rattus norvegicus	98-101
3925951-4	1985	Thus depolarization of plasma membrane, per se, directly induces a release of Ca2+ from intracellular storage sites in vascular smooth muscle cells, and the main fraction of this released Ca2+ is derived from the caffeine sensitive storage sites; perhaps from the sarcoplasmic reticulum.	Caffeine	213-221	carbonic anhydrase 2	Rattus norvegicus	188-191
4027463-1	1985	The effects of caffeine on the electrophysiological properties of CA1 pyramidal neurones were investigated in the rat hippocampal slice preparation in vitro.	Caffeine	15-23	carbonic anhydrase 1	Rattus norvegicus	66-69
3838675-2	1985	Smoking of cigarettes and other inducers of aryl hydrocarbon hydroxylase tend to enhance the caffeine metabolism; pregnancy, the use of oral contraceptives, and various kinds of liver disease prolong the caffeine half-life.	Caffeine	93-101	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-72
2997533-6	1985	Caffeine and carbachol contracted isolated smooth muscle cells and increased intracellular cyclic GMP level.	Caffeine	0-8	5'-nucleotidase, cytosolic II	Homo sapiens	98-101
3838675-2	1985	Smoking of cigarettes and other inducers of aryl hydrocarbon hydroxylase tend to enhance the caffeine metabolism; pregnancy, the use of oral contraceptives, and various kinds of liver disease prolong the caffeine half-life.	Caffeine	204-212	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-72
4084271-0	1985	[Determination of caffeine and metamizole elimination in pregnancy and after delivery as an in vivo method for characterization of various cytochrome p-450 dependent biotransformation reactions].	Caffeine	18-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	150-155
6083428-2	1984	Since we had demonstrated previously that caffeine intake during lactation increased the brain neuropeptide on newborns, we investigated further the effects of the prenatal administration of caffeine on TRH and cyclo (His-Pro).	Caffeine	191-199	thyrotropin releasing hormone	Rattus norvegicus	203-206
3966665-4	1985	The concomitant secretion of catecholamines and dopamine-beta-hydroxylase was observed in response to acetylcholine and caffeine.	Caffeine	120-128	dopamine beta-hydroxylase	Homo sapiens	48-73
3991787-0	1985	[Determination of caffeine and metamizole elimination in men and women with and without hormonal contraceptives as an in vivo method for characterization of various cytochrome P-450 subspecies].	Caffeine	18-26	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	176-181
3991787-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	76-81
3991787-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81
3991787-1	1985	Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB).	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	223-230
3883395-5	1985	In logarithmic-phase cells, we found a strong inhibitory effect of caffeine on the RAD54 mediated repair process.	Caffeine	67-75	DNA-dependent ATPase RAD54	Saccharomyces cerevisiae S288C	83-88
6535155-5	1984	In the present paper we found that caffeine in concentration of 12.5 mmol/liter doubles fraction Ca1, while it does not affect appreciably fraction Ca2.	Caffeine	35-43	carbonic anhydrase 1	Cavia porcellus	97-100
6149265-3	1984	We have observed, however, that the activity of hypoxanthine-guanine phosphoribosyltransferase increases in direct proportion to the concentration of caffeine found in rat brain.	Caffeine	150-158	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	48-94
6149265-6	1984	We have found also that ingestion of large amounts of caffeine increases the activities in rat brain of adenosine deaminase, purine nucleoside phosphorylase, aspartate carbamoyl-transferase, dihydroorotase, and dihydroorotate oxidase.	Caffeine	54-62	adenosine deaminase	Rattus norvegicus	104-123
6149265-6	1984	We have found also that ingestion of large amounts of caffeine increases the activities in rat brain of adenosine deaminase, purine nucleoside phosphorylase, aspartate carbamoyl-transferase, dihydroorotase, and dihydroorotate oxidase.	Caffeine	54-62	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	211-233
6492007-14	1984	is the store from which noradrenaline and caffeine release Ca2+.	Caffeine	42-50	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	59-62
6476593-3	1984	Caffeine increased Pdi at all levels of diaphragmatic electromyographic activity in all 6 subjects.	Caffeine	0-8	peptidyl arginine deiminase 1	Homo sapiens	19-22
6476593-5	1984	Theophylline administered in a dose equal to that of caffeine increased Pdi in 5 of the 6 subjects.	Caffeine	53-61	peptidyl arginine deiminase 1	Homo sapiens	72-75
6476593-6	1984	The magnitude of the increase in Pdi was greater with caffeine than with theophylline, however.	Caffeine	54-62	peptidyl arginine deiminase 1	Homo sapiens	33-36
6476593-7	1984	The greater effect of caffeine than of theophylline on Pdi was not explained by differences in the blood concentrations of the 2 drugs.	Caffeine	22-30	peptidyl arginine deiminase 1	Homo sapiens	55-58
6715798-0	1984	Caffeine stimulates growth hormone secretion by cultured rat pituitary cells.	Caffeine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	20-34
6539286-1	1984	Administration of caffeine, ip 100 mg/kg/day for 1-5 days, to adult male rats resulted in a significant increase in hepatic cytochrome P-450 and b5 concentrations and in cytochrome c reductase, aminopyrine N-demethylase and acetanilide hydroxylase activities.	Caffeine	18-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	124-147
6390995-3	1984	In the fasting rat, intravenous caffeine caused an increase in the serum concentrations of glucose, urea, insulin, and free fatty acids, whereas a decrease in glucoplastic amino acids was found.	Caffeine	32-40	insulin	Homo sapiens	106-113
6390995-5	1984	During simultaneous application of carbohydrates and caffeine, the increases in the concentration of blood glucose and serum insulin were intensified, whereas the serum concentrations of lactate and urea as well as hepatic glycogen were not altered.	Caffeine	53-61	insulin	Homo sapiens	125-132
6390995-6	1984	In fasting male volunteers caffeine caused an increase in the concentrations of blood glucose, cortisol, insulin, free fatty acids, free glycerol and ketone bodies.	Caffeine	27-35	insulin	Homo sapiens	105-112
6390995-9	1984	It is concluded that high dosed caffeine causes peripheral insulin resistance in the human being as well as in the experimental animal.	Caffeine	32-40	insulin	Homo sapiens	59-66
6697446-0	1984	Induction of hepatic ornithine decarboxylase by intraperitoneal administration of caffeine in rats.	Caffeine	82-90	ornithine decarboxylase 1	Rattus norvegicus	21-44
6697446-2	1984	administration of caffeine led to a significant increase in hepatic ornithine decarboxylase activity in rats.	Caffeine	18-26	ornithine decarboxylase 1	Rattus norvegicus	68-91
6697446-6	1984	The possible mechanism of the caffeine-mediated hepatic ornithine decarboxylase induction is discussed.	Caffeine	30-38	ornithine decarboxylase 1	Rattus norvegicus	56-79
6715798-1	1984	To study the effect of caffeine on growth hormone secretion a culture system of dispersed rat anterior pituitary cells was employed.	Caffeine	23-31	gonadotropin releasing hormone receptor	Rattus norvegicus	35-49
6715798-4	1984	A dose dependent stimulatory effect of caffeine on growth hormone secretion into the culture medium was observed.	Caffeine	39-47	gonadotropin releasing hormone receptor	Rattus norvegicus	51-65
6715798-5	1984	It is concluded that caffeine, like other xanthine phosphodiesterase inhibitors stimulates growth hormone secretion by a direct effect on pituitary cells.	Caffeine	21-29	gonadotropin releasing hormone receptor	Rattus norvegicus	91-105
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	29-37	carbonic anhydrase 2	Oryctolagus cuniculus	15-18
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	29-37	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-1	1984	A comparison was made between the properties of the norepinephrine- and caffeine-sensitive Ca2+ store in both intact and skinned smooth muscle of the rabbit mesenteric artery.	Caffeine	72-80	carbonic anhydrase 2	Oryctolagus cuniculus	91-94
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	29-37	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-5	1984	The amplitude of the norepinephrine-induced contraction in Ca2+-free medium also depended on the amount of Ca2+ present in the caffeine-sensitive store.	Caffeine	127-135	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
6689959-5	1984	The amplitude of the norepinephrine-induced contraction in Ca2+-free medium also depended on the amount of Ca2+ present in the caffeine-sensitive store.	Caffeine	127-135	carbonic anhydrase 2	Oryctolagus cuniculus	107-110
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	29-37	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-6	1984	In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+.	Caffeine	38-46	carbonic anhydrase 2	Oryctolagus cuniculus	57-60
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	257-265	carbonic anhydrase 2	Oryctolagus cuniculus	15-18
6689959-6	1984	In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+.	Caffeine	38-46	carbonic anhydrase 2	Oryctolagus cuniculus	94-97
6689959-6	1984	In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+.	Caffeine	38-46	carbonic anhydrase 2	Oryctolagus cuniculus	94-97
6689959-6	1984	In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+.	Caffeine	38-46	carbonic anhydrase 2	Oryctolagus cuniculus	94-97
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	257-265	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	257-265	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Caffeine	257-265	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Caffeine	164-172	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Caffeine	164-172	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Caffeine	164-172	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6319310-2	1984	Caffeine alone produces a rapid transient elevation of cyclic AMP and a slower delayed elevation of cyclic GMP.	Caffeine	0-8	5'-nucleotidase, cytosolic II	Homo sapiens	107-110
6319310-4	1984	A composite pattern is produced by combinations of radiation and caffeine, a distinctive feature of which is an elevated level of cyclic GMP near the time of the radiation-delayed and caffeine-promoted mitosis.	Caffeine	65-73	5'-nucleotidase, cytosolic II	Homo sapiens	137-140
6319310-4	1984	A composite pattern is produced by combinations of radiation and caffeine, a distinctive feature of which is an elevated level of cyclic GMP near the time of the radiation-delayed and caffeine-promoted mitosis.	Caffeine	184-192	5'-nucleotidase, cytosolic II	Homo sapiens	137-140
6319310-5	1984	With pretreatment by caffeine, the least radiation-induced mitotic delay occurs when plasmodia are irradiated during the caffeine-elicited increase in cyclic GMP.	Caffeine	21-29	5'-nucleotidase, cytosolic II	Homo sapiens	158-161
6083404-3	1984	In contrast to agonist-released Ca stores, those released by caffeine to support contraction in Ca2+-free solutions are more slowly lost and refilled, are not always emptied when the agonist-related store is emptied, and do not disappear after saponin treatment.	Caffeine	61-69	carbonic anhydrase 2	Homo sapiens	96-99
6319310-5	1984	With pretreatment by caffeine, the least radiation-induced mitotic delay occurs when plasmodia are irradiated during the caffeine-elicited increase in cyclic GMP.	Caffeine	121-129	5'-nucleotidase, cytosolic II	Homo sapiens	158-161
6319310-6	1984	The plasmodium becomes refractory to the reduction of mitotic delay by caffeine at approximately the time it becomes refractory to the further elevation of cyclic GMP by caffeine.	Caffeine	170-178	5'-nucleotidase, cytosolic II	Homo sapiens	163-166
6686582-1	1983	Caffeine dissolved in drinking-water was available ad lib.	Caffeine	0-8	leucine rich repeat containing 15	Rattus norvegicus	54-57
6387392-1	1984	The addition of 0.1% caffeine to the plating medium markedly reduced the ozone-survival of the wild-type and the rad1 and rad6 mutants of Saccharomyces cerevisiae, whereas no effect was observed in the rad52 mutant.	Caffeine	21-29	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	113-117
6387392-1	1984	The addition of 0.1% caffeine to the plating medium markedly reduced the ozone-survival of the wild-type and the rad1 and rad6 mutants of Saccharomyces cerevisiae, whereas no effect was observed in the rad52 mutant.	Caffeine	21-29	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	122-126
6387392-2	1984	Since, in S. cerevisiae, caffeine has been reported to interfere with the recombinational repair pathway under the control of the RAD52 gene, these results support previous observations suggesting that this pathway is involved in the repair of ozone-induced DNA damage.	Caffeine	25-33	recombinase RAD52	Saccharomyces cerevisiae S288C	130-135
6571228-1	1983	Theophylline (Theo) and caffeine antagonized the inhibitory effect of methionine (Met)-enkephalin, leucine (Leu)-enkephalin and morphine on the twitch height of the field stimulated myenteric plexus longitudinal muscle (MPLM) preparation of the guinea-pig ileum.	Caffeine	24-32	proenkephalin	Rattus norvegicus	87-97
6571228-1	1983	Theophylline (Theo) and caffeine antagonized the inhibitory effect of methionine (Met)-enkephalin, leucine (Leu)-enkephalin and morphine on the twitch height of the field stimulated myenteric plexus longitudinal muscle (MPLM) preparation of the guinea-pig ileum.	Caffeine	24-32	proenkephalin	Rattus norvegicus	113-123
6571228-3	1983	Injection of Theo (20, 40 mg kg-1) or caffeine (40 mg kg-1) reversed or blocked the inhibitory effects of Leu-enkephalin (50 micrograms i.c.v.)	Caffeine	38-46	proenkephalin	Rattus norvegicus	110-120
6336046-8	1984	Caffeine induced shortening in the skinned single cells preloaded with Ca2+, and this shortening was suppressed by procaine.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	71-74
6686582-7	1983	Contrary to results seen after gavage studies, caffeine available ad lib.	Caffeine	47-55	leucine rich repeat containing 15	Rattus norvegicus	69-72
6668464-3	1983	Theophylline and caffeine inhibited by varying degrees the 45Ca efflux from ileal, vas deferens and bladder muscle strips during the slow intracellular phase, but theobromine significantly stimulated 45Ca slow compartment efflux in all three types of muscle.	Caffeine	17-25	arginine vasopressin	Rattus norvegicus	83-86
6665741-1	1983	Caffeine was administered intraperitoneally to CD-1 mice on days 11 and 12 of pregnancy at doses of 80-250 mg/kg.	Caffeine	0-8	CD1 antigen complex	Mus musculus	47-51
6668464-5	1983	Caffeine and theophylline were either without much effect or slightly stimulated calcium binding by microsomes and mitochondria isolated from ileum, vas deferens and bladder, while theobromine significantly inhibited calcium binding by both sub-cellular fractions in all three muscles.	Caffeine	0-8	arginine vasopressin	Rattus norvegicus	149-152
6888193-7	1983	Spontaneous locomotor of the chronic caffeine group was reduced significantly for 4 days after drug-free tap water was substituted for the caffeine solution.	Caffeine	37-45	nuclear RNA export factor 1	Rattus norvegicus	105-108
6611834-8	1983	The contractile response, of frog cardiac muscle to caffeine, would seem to be largely due to a release of Ca2+ from an intracellular store, but the strength of the resulting contracture depends upon a competition between the contractile proteins and the Na/Ca exchange for the released Ca2+.	Caffeine	52-60	carbonic anhydrase 2	Homo sapiens	107-110
6611834-8	1983	The contractile response, of frog cardiac muscle to caffeine, would seem to be largely due to a release of Ca2+ from an intracellular store, but the strength of the resulting contracture depends upon a competition between the contractile proteins and the Na/Ca exchange for the released Ca2+.	Caffeine	52-60	carbonic anhydrase 2	Homo sapiens	287-290
6342491-1	1983	Acutely administered caffeine modestly increases blood pressure, plasma catecholamine levels, plasma renin activity, serum free fatty acid levels, urine production, and gastric acid secretion.	Caffeine	21-29	renin	Homo sapiens	101-106
6413944-1	1983	The possibility that caffeine, a central nervous system stimulant used in neonatal apnea, may produce acute or chronic changes in growth hormone (GH), thyroxine (T4) and thyrotropin (TSH) was studied in the newborn rat.	Caffeine	21-29	gonadotropin releasing hormone receptor	Rattus norvegicus	130-144
6413944-8	1983	A high dose of caffeine had a biphasic effect on T4 with an increase at 4 h and a decrease at 24 h. Thyrotropin-releasing hormone (TRH)-induced TSH release at 24 h was not influenced by caffeine administration.	Caffeine	15-23	thyrotropin releasing hormone	Rattus norvegicus	100-129
6413944-8	1983	A high dose of caffeine had a biphasic effect on T4 with an increase at 4 h and a decrease at 24 h. Thyrotropin-releasing hormone (TRH)-induced TSH release at 24 h was not influenced by caffeine administration.	Caffeine	15-23	thyrotropin releasing hormone	Rattus norvegicus	131-134
6603609-6	1983	Caffeine (25 mM) added to the medium produced a decrease in the intensity of skinned fibers with the simultaneous development of tension, thereby indicating that caffeine induces a release of Ca2+ from the sarcoplasmic reticulum and disorder in the filaments ensues.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	192-195
6603609-6	1983	Caffeine (25 mM) added to the medium produced a decrease in the intensity of skinned fibers with the simultaneous development of tension, thereby indicating that caffeine induces a release of Ca2+ from the sarcoplasmic reticulum and disorder in the filaments ensues.	Caffeine	162-170	carbonic anhydrase 2	Homo sapiens	192-195
6308221-8	1983	Muscle paralysed by Ba2+ responded to caffeine (25 mM) or K+ (100-200 mM) with a contracture.	Caffeine	38-46	bone area 2	Mus musculus	20-23
6830852-1	1983	Cytochrome P-450 substrate interactions were studied with cytochrome P-450 partially purified from livers of untreated, phenobarbital-treated, benzo[a]pyrene-treated and caffeine-treated rats.	Caffeine	170-178	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
6830852-3	1983	Caffeine addition (in vitro) to partially purified cytochrome P-450 altered the hexobarbital, aniline and ethylisocyanide induced spectral change, and decreased NADPH oxidation in presence of substrates aminopyrine and acetanilide.	Caffeine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-67
6830852-5	1983	Our studies suggest that caffeine acts as a true modifier of cytochrome P-450 and is possibly responsible for the formation of abortive complexes with aminopyrine.	Caffeine	25-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	61-77
6184146-5	1982	Enterotoxin specific activity was increased for three strains by adding papaverine (hydrochloride crystalline), for two strains by adding each of caffeine and 3-isobutyl-l-methylxanthine, for one strain by adding each of theophylline, 6-mercaptopurine, and 2-amino-6-mercaptopurine, and for none of the strains by adding imidazole.	Caffeine	146-154	cpe	Clostridium perfringens	0-11
6296694-5	1983	To explore this, chick embryonic myocardial cell aggregates were voltage-clamped during abrupt exposure to caffeine, which is known to release Ca2+ from the sarcoplasmic reticulum.	Caffeine	107-115	carbonic anhydrase 2	Gallus gallus	143-146
6296694-6	1983	The speed of the perfusion system and the relative absence of diffusion barriers in the tissue-cultured cells allowed the effects of caffeine-induced Ca2+ release to be studied on a time scale comparable to that of a single normal beat.	Caffeine	133-141	carbonic anhydrase 2	Gallus gallus	150-153
6600642-7	1983	We suggest that caffeine can modulate GABA responses through two different mechanisms: a potentiation of GABA effects (seen with low doses of caffeine) probably due to Ca2+ mobilization and an antagonism of GABA responses (typically seen with large doses of caffeine) perhaps caused by block of GABA receptor-activated channels.	Caffeine	16-24	GABA type A receptor-associated protein	Homo sapiens	295-308
6133688-10	1983	In contrast with amphibian muscle, the isolated soleus is very sensitive to low doses of caffeine and produces biphasic caffeine contractures which relax in the presence of caffeine.	Caffeine	120-128	neurogenin 3	Rattus norvegicus	148-153
6133688-10	1983	In contrast with amphibian muscle, the isolated soleus is very sensitive to low doses of caffeine and produces biphasic caffeine contractures which relax in the presence of caffeine.	Caffeine	120-128	neurogenin 3	Rattus norvegicus	148-153
6306233-15	1983	These results strongly support the possible key role that the redistribution and influx of Ca2+ may play in lipolysis induced by epinephrine, norepinephrine, caffeine and ACTH, and further suggest that calmodulin may affect lipolysis.	Caffeine	158-166	calmodulin 1	Rattus norvegicus	202-212
6654831-2	1983	Caffeine enhances lethality of agents such as HN2.	Caffeine	0-8	MT-RNR2 like 2 (pseudogene)	Homo sapiens	46-49
7201410-0	1982	Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.	Caffeine	48-56	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	79-87
7083737-1	1982	Caffeine (TMX) disposition was studied in mean after 1, 5, and 10 mg/kg in water, as mocha coffee (1.54 mg/kg) and as a soft drink (0.22 mg/kg).	Caffeine	0-8	thioredoxin related transmembrane protein 1	Homo sapiens	10-13
7044577-4	1982	This increase in dTTP level is probably due to an effect of caffeine on the DNA synthesis process and synthesis of dTDP-sugars.	Caffeine	60-68	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	115-119
6953438-3	1982	Our results show that caffeine potentiates the lethality of the nitrogen mustard 2-chloro-N-(2-chloroethyl)-N-methylethanamine (HN2) by inducing damaged cells to undergo mitosis before properly repairing lesions in their DNA.	Caffeine	22-30	MT-RNR2 like 2 (pseudogene)	Homo sapiens	128-131
7045654-4	1982	A repair pathway is postulated which is pre-replicative, unaffected by chloramphenicol, acriflavine or caffeine, and inhibited at 0 degrees C. It is unaffected by a rep mutation but is blocked by a polA mutation, suggesting that it involves DNA strand breakage and at least some exonuclease action.	Caffeine	103-111	replication protein	Escherichia coli	2-5
6953438-8	1982	Caffeine (2mM) increased the lethality of HN2 by 5- to 10-fold.	Caffeine	0-8	MT-RNR2 like 2 (pseudogene)	Homo sapiens	42-45
6262487-2	1981	Caffeine and theophylline inhibited the 5"-nucleotidase in both fractions, but theophylline appeared to be a more potent agent.	Caffeine	0-8	5'-nucleotidase ecto	Homo sapiens	40-55
6806648-2	1982	The genetic factor rar-1: effects in immature oocytes and their inhibition by caffeine.	Caffeine	78-86	rar1	Drosophila melanogaster	19-24
6806648-4	1982	Previous data tentatively indicated an inhibition of rar-1 by caffeine.	Caffeine	62-70	rar1	Drosophila melanogaster	53-58
6806648-6	1982	The results show that it is the effect of rar-1 which is inhibited by caffeine.	Caffeine	70-78	rar1	Drosophila melanogaster	42-47
6974505-10	1981	Prolonged fatigue is not due to energy exhaustion or to the inability of muscle fibers to consume residual ATP but probably arises from long-lasting interference in excitation-contraction coupling, which can be reversed by KCl- or caffeine-induced release of Ca2+ from intracellular stores.	Caffeine	231-239	carbonic anhydrase 2	Homo sapiens	259-262
6263423-1	1981	The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate.	Caffeine	167-175	2',3'-cyclic nucleotide 3' phosphodiesterase	Bos taurus	36-80
6263423-1	1981	The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate.	Caffeine	167-175	2',3'-cyclic nucleotide 3' phosphodiesterase	Bos taurus	82-85
6273540-14	1981	In split fibres the force produced with the release of Ca2+ from the SR by caffeine was 60-100% larger when cyclic AMP was added to the previous loading solution.	Caffeine	75-83	carbonic anhydrase 2	Homo sapiens	55-58
6271685-0	1981	Stimulation of Clostridium perfringens enterotoxin formation by caffeine and theobromine.	Caffeine	64-72	cpe	Clostridium perfringens	39-50
6271685-5	1981	In the case of NCTC 8238, caffeine and theobromine caused a three- to fourfold increase in the percentages of cells possessing refractile spores and a similar increase in enterotoxin concentration.	Caffeine	26-34	cpe	Clostridium perfringens	171-182
6262487-5	1981	The inhibitory effect of caffeine and theophylline on 5"-nucleotidase may not be related to their actions on phosphodiesterase since dipyridamole and papaverine, which are also known to inhibit phosphodiesterase, did not affect the 5"-nucleotidase activity.	Caffeine	25-33	5'-nucleotidase ecto	Homo sapiens	54-69
6782472-6	1981	The genetic factor rar-1 contributes to the system with respect to the induction of dominant (DRF = 1.31) and sex-linked recessive lethals (DRF = 1.31) in a way that is inhibited by caffeine.	Caffeine	182-190	rar1	Drosophila melanogaster	19-24
7348693-1	1981	1 In Charles River CD1 mice, a single dose of 100 mg kg-1 caffeine injected intraperitoneally on day 14 of pregnancy caused a low incidence of cleft palate in the fetuses.	Caffeine	58-66	CD1 antigen complex	Mus musculus	19-22
7009653-1	1981	Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines.	Caffeine	6-14	renin	Homo sapiens	170-175
6766745-0	1980	Structural changes induced in glycogen phosphorylase b by the binding of glucose and caffeine.	Caffeine	85-93	glycogen phosphorylase B	Homo sapiens	30-54
7308271-6	1981	Both high caffeine intake and cigarette smoking increased AHH activity in the absence of any change in cytochrome P-450 content.	Caffeine	10-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-61
6998814-8	1980	Caffeine elicited insulin release in the absence of glucose and enhanced insulin release in response to 10 mmol/l glucose.	Caffeine	0-8	insulin	Homo sapiens	18-25
6998814-8	1980	Caffeine elicited insulin release in the absence of glucose and enhanced insulin release in response to 10 mmol/l glucose.	Caffeine	0-8	insulin	Homo sapiens	73-80
7189555-0	1980	Caffeine and theophylline: serum/CSF correlation in premature infants.	Caffeine	0-8	colony stimulating factor 2	Homo sapiens	33-36
6997162-6	1980	Caffeine (5 and 10 mM), a phosphodiesterase inhibitor, potentiated insulin release by itself and also induced the glucose-stimulated insulin release from the fetal pancreata in the dose related manner.	Caffeine	0-8	insulin	Homo sapiens	67-74
6997162-6	1980	Caffeine (5 and 10 mM), a phosphodiesterase inhibitor, potentiated insulin release by itself and also induced the glucose-stimulated insulin release from the fetal pancreata in the dose related manner.	Caffeine	0-8	insulin	Homo sapiens	133-140
6997162-8	1980	In the presence of caffeine, the significant increase of insulin release from fetal pancreata was observed with L-leucine, but not with L-arginine.	Caffeine	19-27	insulin	Homo sapiens	57-64
6997162-10	1980	By contrast, glucose (100 and 300 mg/100 ml), tolbutamide (100 microgram/ml), L-arginine (10 mM) and caffeine (5 mM) caused a significant increase of insulin release from adult pancreata.	Caffeine	101-109	insulin	Homo sapiens	150-157
6766745-1	1980	The allosteric inhibitors glucose and caffeine cause significant structural alterations in glycogen phosphorylase b (1,4-alpha-D-glucan:orthophosphate alpha-D-glucosyltransferase, EC 2.4.1.1).	Caffeine	38-46	glycogen phosphorylase B	Homo sapiens	91-115
6159765-1	1980	The fact that histamine H2-receptor antagonists strongly inhibit basal and nocturnal gastric secretion and acid secretion stimulated by histamine, pentagastrin, caffeine, insulin, sham feeding and food indicate that histamine plays a physiological role in gastric acid secretion.	Caffeine	161-169	histamine receptor H2	Homo sapiens	14-35
7403247-1	1980	Part 5: Assay of caffeine.	Caffeine	17-25	tankyrase	Homo sapiens	0-6
509418-0	1979	The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine.	Caffeine	84-92	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	34-62
509418-1	1979	The activity of aryl hydrocarbon hydroxylase (AHH) of murine liver is increased by caffeine.	Caffeine	83-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	16-44
509418-1	1979	The activity of aryl hydrocarbon hydroxylase (AHH) of murine liver is increased by caffeine.	Caffeine	83-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-49
509418-5	1979	The Km of AHH for benzo[a]pyrene is decreased in the presence of caffeine.	Caffeine	65-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	10-13
509418-6	1979	Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH.	Caffeine	24-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	129-132
480049-0	1979	Relationship of plasma and CSF concentrations of caffeine in neonates with apnea.	Caffeine	49-57	colony stimulating factor 2	Homo sapiens	27-30
428003-4	1979	Enhancement of chromosomal damage and potentiation of lethal effect of cis-PAD by 0.75 mM caffeine were found in cis-PAD and UV light-resistant L5178Y-S strain but not in cis-PAD and UV light-sensitive L5178Y-R strain.	Caffeine	90-98	paddle	Mus musculus	75-78
504315-0	1979	Effects of caffeine on FT-1 min schedule induced drinking at different body weights.	Caffeine	11-19	AKT interacting protein	Homo sapiens	23-27
428003-4	1979	Enhancement of chromosomal damage and potentiation of lethal effect of cis-PAD by 0.75 mM caffeine were found in cis-PAD and UV light-resistant L5178Y-S strain but not in cis-PAD and UV light-sensitive L5178Y-R strain.	Caffeine	90-98	paddle	Mus musculus	117-120
428003-4	1979	Enhancement of chromosomal damage and potentiation of lethal effect of cis-PAD by 0.75 mM caffeine were found in cis-PAD and UV light-resistant L5178Y-S strain but not in cis-PAD and UV light-sensitive L5178Y-R strain.	Caffeine	90-98	paddle	Mus musculus	117-120
428003-5	1979	These results suggest that the extreme sensitivity of L5178Y-R strain to cis-PAD and UV light is caused to some extent by deficiency in a caffeine-sensitive post-replication repair system.	Caffeine	138-146	paddle	Mus musculus	77-80
301524-5	1977	It is postulated that the increased Ca2+ concentration in the sarcoplasm resulting from electrical stimulus or caffeine treatment activates the myosin light chain kinase which phosphorylates the 18,000-dalton light chain.	Caffeine	111-119	myosin heavy chain 14	Homo sapiens	144-150
310523-7	1978	It is argued that caffeine causes a Ca2+-induced release of Ca2+ (the CROC) from the S.R.	Caffeine	18-26	carbonic anhydrase 2	Homo sapiens	36-39
310523-7	1978	It is argued that caffeine causes a Ca2+-induced release of Ca2+ (the CROC) from the S.R.	Caffeine	18-26	carbonic anhydrase 2	Homo sapiens	60-63
339084-1	1978	Using a double-blind, randomized, cross-over protocol, we studied the effect of a single dose of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine healthy, young, non-coffee drinkers maintained in sodium balance throughout the study period.	Caffeine	102-110	renin	Homo sapiens	121-126
339084-3	1978	Caffeine increased plasma renin activity by 57 per cent, plasma norepinephrine by 75 per cent and plasma epinephrine by 207 per cent.	Caffeine	0-8	renin	Homo sapiens	26-31
339084-9	1978	Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion.	Caffeine	30-38	renin	Homo sapiens	73-78
210140-10	1978	Caffeine increased the infectivity of CMV irradiated with lowest UV dose (3,120 erg/mm2) but did not increase the infectivity of virus irradiated with 12,480 erg/mm2.	Caffeine	0-8	PNMA family member 2	Homo sapiens	84-87
179611-9	1976	The homogenate incubation in a medium containing 10(-5) M epinephrine or 10(-7) M caffeine and 5 mM Mg2+ leads to an increase in the GAMT activity.	Caffeine	82-90	guanidinoacetate N-methyltransferase	Rattus norvegicus	133-137
189845-14	1977	With the exception of insulin, all of these agents showed much more potent inhibition of caffeine-stimulated lipolysis than of hormone-stimulated lipolysis.	Caffeine	89-97	insulin	Homo sapiens	22-29
1033273-2	1976	Immunization of rabbits with an antigen prepared by coupling 7-(5-carboxypentyl)-1,3-dimethylxanthine to bovine serum albumin resulted in the formation of antibodies selective for caffeine as opposed to various mono- and dimethylxanthines, mono-, di-, and trimethyluric acids and a variety of common drugs.	Caffeine	180-188	albumin	Oryctolagus cuniculus	118-125
950953-3	1976	Normal fibroblasts, Lesch-Nyhan fibroblasts, xeroderma pigmentosum fibroblasts, HeLa cells, wild type mouse cells, and adenine phosphoribosyl-transferase-deficient mouse cells all seem to metabolize caffeine similarly.	Caffeine	199-207	adenine phosphoribosyl transferase	Mus musculus	119-153
176892-7	1976	Caffeine at a concentration of 10 mM inhibited Ca-ATPase significantly in secretory granules and microsomes.	Caffeine	0-8	dynein, axonemal, heavy chain 8	Mus musculus	50-56
874025-4	1977	The behaviour of theophylline and other xanthine derivatives, theobromine, caffeine and 8-chlorotheophylline, on a bonded octadecyl reversed-phase system suggests that C18 phase effects solute separation by mixed retention mechanisms rather than by pure reversed-phase chromatography.	Caffeine	75-83	Bardet-Biedl syndrome 9	Homo sapiens	168-171
190648-1	1977	The methyl xanthines, theophylline, caffeine and 3-isobutyl-1 methyl xanthine (MIX) inhibited the pressure responses to noradrnealine, angiotensin II and potassium ions in the isolated perfused mesenteric vascular bed of the male rat.	Caffeine	36-44	angiotensinogen	Rattus norvegicus	135-149
826452-7	1976	In mei-9 cells DNA synthesis and possibly postreplication repair are weakly sensitive to caffeine.	Caffeine	89-97	meiotic 9	Drosophila melanogaster	3-8
969704-0	1976	[The effect of caffeine on the serum insulin level during intravenous glucose tolerance test in patients with chemical diabetes].	Caffeine	15-23	insulin	Homo sapiens	37-44
180977-3	1976	Poly(ADP-ribose) polymerase is inhibited by ATP, thymidine, nicotinamide, theophylline, 3-isobutyl-1-methylxanthine and caffeine and stimulated by actinomycin D.	Caffeine	120-128	poly (ADP-ribose) polymerase 1	Rattus norvegicus	0-27
1204863-4	1975	The CBR could be reduced by isopropilnoradrenaline, acetylcholine, histamine, and caffeine.	Caffeine	82-90	cannabinoid receptor 1	Felis catus	4-7
765799-4	1975	Caffeine significantly affects LH recovery of DEB-treated RAD strain, slightly decreases recovery of rad3 and has almost no effect on survival of rad6.	Caffeine	0-8	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	101-105
765799-5	1975	When DEB-treated cultures are plated immediately on caffeine-containing medium, survival of rad3 decreases more significantly than that of the RAD strain, whereas survival of rad6 is only slightly decreased as compared with the untreated cultures.	Caffeine	52-60	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	92-96
133361-0	1976	Effect of dihydroxyphenylalanine, imipramine and coffeine on the light induced decrease in nocturnal serotonin N-acetyltransferase in the rat pineal gland.	Caffeine	49-57	aralkylamine N-acetyltransferase	Rattus norvegicus	101-130
1190514-5	1975	Simultaneous addition of serum (kininogen source) and kallikrein to semen samples led to a sitmulation of total sperm motility with higher mean values than those obtained by caffeine of kallikrein alone.	Caffeine	174-182	kallikrein related peptidase 4	Homo sapiens	54-64
1165941-0	1975	[Immunoreactive insulin in children following oral administration of caffeine].	Caffeine	69-77	insulin	Homo sapiens	16-23
1203355-4	1975	Caffeine (10(-4) M) and papaverine (10(-7) M) activated GAMT in retina and rat Harderian gland, while cycloheximide, a protein synthesis inhibitor (0.5-2 mkg/ml), eliminated caffeine-stimulated GAMT activity.	Caffeine	0-8	guanidinoacetate N-methyltransferase	Rattus norvegicus	56-60
1203355-4	1975	Caffeine (10(-4) M) and papaverine (10(-7) M) activated GAMT in retina and rat Harderian gland, while cycloheximide, a protein synthesis inhibitor (0.5-2 mkg/ml), eliminated caffeine-stimulated GAMT activity.	Caffeine	0-8	guanidinoacetate N-methyltransferase	Rattus norvegicus	194-198
1190514-7	1975	Simultaneous addition of caffeine and kallikrein led to a further improvement of sperm motility which was significantly above that produced by caffeine or kallikrein alone.	Caffeine	25-33	kallikrein related peptidase 4	Homo sapiens	155-165
1190514-7	1975	Simultaneous addition of caffeine and kallikrein led to a further improvement of sperm motility which was significantly above that produced by caffeine or kallikrein alone.	Caffeine	143-151	kallikrein related peptidase 4	Homo sapiens	38-48
1190514-8	1975	This observation and the finding of a different response of the spermatozoa of two ejaculates towards caffeine of kallikrein indicate that caffeine (cyclic AMP) interferes quite differently in comparison to kallikrein (kinins) in stimulating sperm motility.	Caffeine	102-110	kallikrein related peptidase 4	Homo sapiens	114-124
1190514-8	1975	This observation and the finding of a different response of the spermatozoa of two ejaculates towards caffeine of kallikrein indicate that caffeine (cyclic AMP) interferes quite differently in comparison to kallikrein (kinins) in stimulating sperm motility.	Caffeine	139-147	kallikrein related peptidase 4	Homo sapiens	114-124
4353086-5	1973	Glucagon, theophylline, caffeine and 3-isobutyl-1-methylxanthine, agents that raise cyclic AMP concentrations in islet cells and stimulate insulin release, increased protein kinase activity.	Caffeine	24-32	insulin	Homo sapiens	139-146
4802050-0	1973	[Effect of secretin on gastric secretion stimulated by caffeine (author"s transl)].	Caffeine	55-63	secretin	Homo sapiens	11-19
14792799-0	1950	[Comparison of the effect of some puric alkaloids (caffeine, theobromine, theophylline and theophylline-ethylenediamine) on cholinesterase].	Caffeine	51-59	butyrylcholinesterase	Homo sapiens	124-139
4120134-0	1972	Effect of caffeine and theophylline on Mg ++ -dependent ATPase.	Caffeine	10-18	dynein axonemal heavy chain 8	Homo sapiens	56-62
4320973-7	1970	Dibutyryl cyclic AMP, with or without caffeine, caused an up to 300% increase in labeled growth hormone release.	Caffeine	38-46	gonadotropin releasing hormone receptor	Rattus norvegicus	89-103
4176939-6	1968	At low ATP concentrations when the transport system is under maximal control by accumulated Ca, caffeine inhibits the ATPase activity without affecting the rate of Ca inflow.	Caffeine	96-104	dynein axonemal heavy chain 8	Homo sapiens	118-124
5158204-4	1971	Compounds which inhibit catechol-O-methyltransferase (pyrogallol, tropolone, U-0521) potentiated responses to catecholamines and abolished the enhancing effect of theophylline and caffeine.	Caffeine	180-188	catechol O-methyltransferase	Oryctolagus cuniculus	24-52
5797248-0	1969	[Effect of histamine, caffeine and ethanol on the secretion of gastric lipase in children].	Caffeine	22-30	lipase F, gastric type	Homo sapiens	63-77
4164302-0	1967	Enhancement by caffeine of glucagon-induced and tolbutamide-induced insulin release from isolated foetal pancreatic tissue.	Caffeine	15-23	insulin	Homo sapiens	68-75
14404248-0	1959	[The determination of antipyrine and caffeine in the presence of phenacetin with the aid of ion exchange resins].	Caffeine	37-45	activation induced cytidine deaminase	Homo sapiens	85-88
33353849-4	2021	Furthermore, recent reports have delved into their more complex structural associations with key modulators - proteins such as the dihydropyridine receptor (DHPR), FKBP12/12.6, and calmodulin (CaM), as well as ions and small molecules including Ca2+, ATP, caffeine, and PCB95.	Caffeine	256-264	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	131-155
33336382-8	2021	In addition, metamizole weakly inhibited CYP1A2 activity (1.79-fold increase in the caffeine AUC).	Caffeine	84-92	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
34030369-7	2021	In the STP outlets, a strict decline of biochemical oxygen demand, >95% removal of caffeine, and absence of viral copies reflect the efficiency of the treatment plants in Chennai city.	Caffeine	83-91	thyroid hormone receptor interactor 10	Homo sapiens	7-10
33353849-4	2021	Furthermore, recent reports have delved into their more complex structural associations with key modulators - proteins such as the dihydropyridine receptor (DHPR), FKBP12/12.6, and calmodulin (CaM), as well as ions and small molecules including Ca2+, ATP, caffeine, and PCB95.	Caffeine	256-264	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	157-161
33353849-4	2021	Furthermore, recent reports have delved into their more complex structural associations with key modulators - proteins such as the dihydropyridine receptor (DHPR), FKBP12/12.6, and calmodulin (CaM), as well as ions and small molecules including Ca2+, ATP, caffeine, and PCB95.	Caffeine	256-264	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	164-175
34053199-3	2021	A PBPK model of caffeine was stepwise personalized by using individual data on (1) demography, (2) physiology, and (3) CYP1A2 phenotype of 48 healthy volunteers participating in a single-dose clinical study.	Caffeine	16-24	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
34043345-9	2021	This phenomenon can be reversed by an ATM/ATR inhibitor, caffeine.	Caffeine	57-65	ATM serine/threonine kinase	Homo sapiens	38-41
34056932-0	2021	Acupuncture stimulation at HT7 as a non-pharmacological therapy for sleep disorder caused by caffeine administration in rats.	Caffeine	93-101	basigin (Ok blood group)	Rattus norvegicus	27-30
34056932-2	2021	The present study was designed to investigate the hypnotic effect of acupuncture stimulation at HT7 on caffeine-induced sleep disorders and locomotor activity in rats.	Caffeine	103-111	basigin (Ok blood group)	Rattus norvegicus	96-99
34056932-7	2021	Caffeine injection also increased locomotor activity and c-Fos expression in the medial septum-vertical limb of the diagonal band of Broca (MS-VDB), one of the arousal regions of the basal forebrain.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
34056932-8	2021	Stimulation at HT7 with the MAI alleviated the caffeine-induced sleep disturbance and the increase in locomotor activity.	Caffeine	47-55	basigin (Ok blood group)	Rattus norvegicus	15-18
34056932-9	2021	In addition, MAI treatment at HT7, compared with treatment at a location not corresponding to any traditional acupuncture point, reduced the caffeine-induced increase in c-Fos expression.	Caffeine	141-149	basigin (Ok blood group)	Rattus norvegicus	30-33
34056932-9	2021	In addition, MAI treatment at HT7, compared with treatment at a location not corresponding to any traditional acupuncture point, reduced the caffeine-induced increase in c-Fos expression.	Caffeine	141-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	170-175
34056932-10	2021	CONCLUSION: These results indicate that the hypnotic effect of HT7 acupuncture stimulation on caffeine-induced insomnia was associated with suppression of neuronal activity in the basal forebrain.	Caffeine	94-102	basigin (Ok blood group)	Rattus norvegicus	63-66
34037986-11	2021	The immunolabelling for RANKL, TRAP, and IL-1beta was significantly higher in the CAF group when compared to the control, p < 0.05.	Caffeine	82-85	TNF superfamily member 11	Rattus norvegicus	24-29
34037986-11	2021	The immunolabelling for RANKL, TRAP, and IL-1beta was significantly higher in the CAF group when compared to the control, p < 0.05.	Caffeine	82-85	tudor domain containing 7	Rattus norvegicus	31-35
34037986-11	2021	The immunolabelling for RANKL, TRAP, and IL-1beta was significantly higher in the CAF group when compared to the control, p < 0.05.	Caffeine	82-85	interleukin 1 alpha	Rattus norvegicus	41-49
34037986-13	2021	CONCLUSION: Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL-1beta, and TRAP.	Caffeine	22-30	TNF superfamily member 11	Rattus norvegicus	220-225
34037986-13	2021	CONCLUSION: Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL-1beta, and TRAP.	Caffeine	22-30	interleukin 1 alpha	Rattus norvegicus	227-235
34037986-13	2021	CONCLUSION: Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL-1beta, and TRAP.	Caffeine	22-30	tudor domain containing 7	Rattus norvegicus	241-245
34041763-0	2021	Simultaneous quantitation of serum caffeine and its metabolites by UHPLC-MS/MS for CYP1A2 activity prediction in premature infants.	Caffeine	35-43	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-89
34041763-1	2021	Caffeine is accepted as a probe of cytochrome P450 1A2 enzyme (CYP1A2) activity and is commonly used in premature infants with great interindividual variability of metabolism.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	35-61
34041763-1	2021	Caffeine is accepted as a probe of cytochrome P450 1A2 enzyme (CYP1A2) activity and is commonly used in premature infants with great interindividual variability of metabolism.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69
34041763-2	2021	To evaluate the change characteristics of CYP1A2 activity in premature infants, an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and optimized for the simultaneous quantitation of serum caffeine (CA) and its major metabolites, including paraxanthine (PX), theophylline (TP) and theobromine (TB) in premature infants.	Caffeine	245-253	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
34041763-7	2021	The results suggested that the serum concentration ratios of caffeine metabolic could be used to predict the changes in CYP1A2 enzyme activity in premature infants.	Caffeine	61-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-126
34036605-5	2021	Moreover, CGA + caffeine inhibited the mRNA expression of major adipogenic markers, PPAR-gamma2, and C/EBPalpha in the metaphase and anaphase stages of differentiation induction (Day 2 and 4).	Caffeine	16-24	peroxisome proliferator activated receptor gamma	Mus musculus	84-95
34036605-5	2021	Moreover, CGA + caffeine inhibited the mRNA expression of major adipogenic markers, PPAR-gamma2, and C/EBPalpha in the metaphase and anaphase stages of differentiation induction (Day 2 and 4).	Caffeine	16-24	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	101-111
34036605-6	2021	CGA + caffeine improved P-AMPK/AMPK accompanied by decreasing the expression of GPDH and FAS to depress the lipid synthesis, increasing the mRNA expression of ACO and CAT to promote fatty acid oxidation and up-regulated the expression of hydrolysis-related enzyme adipose TG lipase (ATGL) and P-HSL/HSL.	Caffeine	6-14	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	80-84
34036605-6	2021	CGA + caffeine improved P-AMPK/AMPK accompanied by decreasing the expression of GPDH and FAS to depress the lipid synthesis, increasing the mRNA expression of ACO and CAT to promote fatty acid oxidation and up-regulated the expression of hydrolysis-related enzyme adipose TG lipase (ATGL) and P-HSL/HSL.	Caffeine	6-14	patatin-like phospholipase domain containing 2	Mus musculus	264-281
34036605-6	2021	CGA + caffeine improved P-AMPK/AMPK accompanied by decreasing the expression of GPDH and FAS to depress the lipid synthesis, increasing the mRNA expression of ACO and CAT to promote fatty acid oxidation and up-regulated the expression of hydrolysis-related enzyme adipose TG lipase (ATGL) and P-HSL/HSL.	Caffeine	6-14	patatin-like phospholipase domain containing 2	Mus musculus	283-287
34036605-6	2021	CGA + caffeine improved P-AMPK/AMPK accompanied by decreasing the expression of GPDH and FAS to depress the lipid synthesis, increasing the mRNA expression of ACO and CAT to promote fatty acid oxidation and up-regulated the expression of hydrolysis-related enzyme adipose TG lipase (ATGL) and P-HSL/HSL.	Caffeine	6-14	lipase, hormone sensitive	Mus musculus	295-298
34036605-6	2021	CGA + caffeine improved P-AMPK/AMPK accompanied by decreasing the expression of GPDH and FAS to depress the lipid synthesis, increasing the mRNA expression of ACO and CAT to promote fatty acid oxidation and up-regulated the expression of hydrolysis-related enzyme adipose TG lipase (ATGL) and P-HSL/HSL.	Caffeine	6-14	lipase, hormone sensitive	Mus musculus	299-302
34036605-7	2021	Furthermore, CGA + caffeine improved the expression of Glut4 which promoted the glucose transport.	Caffeine	19-27	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	55-60
34043345-9	2021	This phenomenon can be reversed by an ATM/ATR inhibitor, caffeine.	Caffeine	57-65	ATR serine/threonine kinase	Homo sapiens	42-45
33556562-0	2021	Effects of sub-chronic caffeine ingestion on memory and the hippocampal Akt, GSK-3beta and ERK signaling in mice.	Caffeine	23-31	glycogen synthase kinase 3 alpha	Mus musculus	77-86
34022226-5	2021	Here we assessed the impact of CTD disease-associated mutations P4902S, P4902L, E4950K, and G4955E on Ca2+- and caffeine-mediated activation of RyR2.	Caffeine	112-120	ryanodine receptor 2	Homo sapiens	144-148
34022226-8	2021	All four disease mutations increased caffeine-mediated activation of RyR2 and reduced the threshold for activation and termination of spontaneous Ca2+ release.	Caffeine	37-45	ryanodine receptor 2	Homo sapiens	69-73
33951339-0	2021	A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects.	Caffeine	137-145	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
33556562-6	2021	Furthermore, this memory enhancing dose of caffeine elevated the ratios of phosphorylated to total contents of hippocampal Akt, GSK-3beta and ERK.	Caffeine	43-51	thymoma viral proto-oncogene 1	Mus musculus	123-126
33556562-6	2021	Furthermore, this memory enhancing dose of caffeine elevated the ratios of phosphorylated to total contents of hippocampal Akt, GSK-3beta and ERK.	Caffeine	43-51	glycogen synthase kinase 3 alpha	Mus musculus	128-137
33556562-6	2021	Furthermore, this memory enhancing dose of caffeine elevated the ratios of phosphorylated to total contents of hippocampal Akt, GSK-3beta and ERK.	Caffeine	43-51	mitogen-activated protein kinase 1	Mus musculus	142-145
33556562-7	2021	This study suggests that sub-chronic low dose of caffeine improves memory and increases the phosphorylation of hippocampal Akt, GSK-3beta and ERK proteins.	Caffeine	49-57	thymoma viral proto-oncogene 1	Mus musculus	123-126
33556562-7	2021	This study suggests that sub-chronic low dose of caffeine improves memory and increases the phosphorylation of hippocampal Akt, GSK-3beta and ERK proteins.	Caffeine	49-57	glycogen synthase kinase 3 alpha	Mus musculus	128-137
33556562-7	2021	This study suggests that sub-chronic low dose of caffeine improves memory and increases the phosphorylation of hippocampal Akt, GSK-3beta and ERK proteins.	Caffeine	49-57	mitogen-activated protein kinase 1	Mus musculus	142-145
32959983-12	2021	False-positive results were obtained for the ICP samples at 32% (8/25), due to possible PDE5 inhibition by caffeine.	Caffeine	107-115	phosphodiesterase 5A	Homo sapiens	88-92
33791010-10	2021	Relative to that in the DM group, the expression levels of NGF, BDNF and CGRP in the bladder tissue of DM + caffeine rats increased; cellular apoptosis in the DRG of DM + caffeine rates decreased; and the expression levels of Bcl-2, Bax, cleaved caspase-3 and cleaved caspase-9 proteins in the DRG of DM + caffeine rats were restored to a certain extent.	Caffeine	108-116	nerve growth factor	Rattus norvegicus	59-62
33791010-10	2021	Relative to that in the DM group, the expression levels of NGF, BDNF and CGRP in the bladder tissue of DM + caffeine rats increased; cellular apoptosis in the DRG of DM + caffeine rates decreased; and the expression levels of Bcl-2, Bax, cleaved caspase-3 and cleaved caspase-9 proteins in the DRG of DM + caffeine rats were restored to a certain extent.	Caffeine	108-116	brain-derived neurotrophic factor	Rattus norvegicus	64-68
33791010-10	2021	Relative to that in the DM group, the expression levels of NGF, BDNF and CGRP in the bladder tissue of DM + caffeine rats increased; cellular apoptosis in the DRG of DM + caffeine rates decreased; and the expression levels of Bcl-2, Bax, cleaved caspase-3 and cleaved caspase-9 proteins in the DRG of DM + caffeine rats were restored to a certain extent.	Caffeine	108-116	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
33825858-9	2021	The E4146K mutation markedly suppressed caffeine activation of RyR2 and abolished store overload induced Ca2+ release in HEK293 cells.	Caffeine	40-48	ryanodine receptor 2	Homo sapiens	63-67
33991466-8	2021	Finally, PKA inhibition significantly suppressed caffeine-induced myoglobin expression in L6 myotubes.	Caffeine	49-57	myoglobin	Homo sapiens	66-75
33991466-9	2021	These results suggest that caffeine increases myoglobin expression via the cAMP/PKA pathway in skeletal muscle cells.	Caffeine	27-35	myoglobin	Homo sapiens	46-55
33492703-12	2021	However it is yet to be elucidated whether this is through caffeine"s modulating effects on brain BDNF.	Caffeine	59-67	brain derived neurotrophic factor	Homo sapiens	98-102
33991466-0	2021	Caffeine increases myoglobin expression via the cyclic AMP pathway in L6 myotubes.	Caffeine	0-8	myoglobin	Homo sapiens	19-28
33991466-3	2021	However, no study has shown that caffeine increases the endogenous expression of myoglobin in muscle cells.	Caffeine	33-41	myoglobin	Homo sapiens	81-90
33991466-5	2021	Therefore, our aim was to investigate whether caffeine and activators of the calcium signaling and cAMP/PKA pathway increase the expression of myoglobin in L6 myotubes and whether the pathway mediates caffeine-induced myoglobin expression.	Caffeine	46-54	myoglobin	Homo sapiens	143-152
33991466-5	2021	Therefore, our aim was to investigate whether caffeine and activators of the calcium signaling and cAMP/PKA pathway increase the expression of myoglobin in L6 myotubes and whether the pathway mediates caffeine-induced myoglobin expression.	Caffeine	201-209	myoglobin	Homo sapiens	218-227
33991466-6	2021	Caffeine increased myoglobin expression and activated the cAMP/PKA pathway in L6 muscle cells.	Caffeine	0-8	myoglobin	Homo sapiens	19-28
33825858-11	2021	The G4935R mutation completely abolished caffeine activation of and [3H]ryanodine binding to RyR2.	Caffeine	41-49	ryanodine receptor 2	Homo sapiens	93-97
33905778-1	2021	This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice.	Caffeine	39-47	retina and anterior neural fold homeobox	Homo sapiens	101-104
33987207-0	2021	Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor.	Caffeine	26-34	adenosine A2a receptor	Homo sapiens	52-74
33995046-4	2021	As both caffeine and furanocoumarin bioactive are metabolized by the same hepatic CYP1A1/2 isozyme in humans, caffeine/ARFP product interactions may occur after co-administration.	Caffeine	8-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-90
33995046-4	2021	As both caffeine and furanocoumarin bioactive are metabolized by the same hepatic CYP1A1/2 isozyme in humans, caffeine/ARFP product interactions may occur after co-administration.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-90
33905778-7	2021	Using a PBK model to estimate human blood concentrations following exposure to caffeine, an acceptable Margin of Internal Exposure (MOIE) of 27-fold was derived on the basis of a RAX using theophylline animal data, which suggests that the NGRA approach for caffeine is sufficiently conservative to protect human health.	Caffeine	79-87	retina and anterior neural fold homeobox	Homo sapiens	179-182
33849480-1	2021	BACKGROUND: Caffeine is a known inhibitor of Clozapine metabolism mediated by inhibition of CYP1A2.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	92-98
33888780-5	2021	Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes.	Caffeine	107-115	epidermal growth factor receptor	Homo sapiens	134-138
33888780-8	2021	Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease.	Caffeine	71-79	epidermal growth factor receptor	Homo sapiens	121-125
33888780-10	2021	In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.	Caffeine	66-74	epidermal growth factor receptor	Homo sapiens	112-116
33920292-4	2021	Carriers of the TNF-alpha SNP A allele appear to be more sensitive than homozygote G/G genotype to an attenuating effect of caffeine on PVT lapses during sleep deprivation only because they seem more degraded, but they do not perform better as a result.	Caffeine	124-132	tumor necrosis factor	Homo sapiens	16-25
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	71-79	catechol-O-methyltransferase	Homo sapiens	25-29
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	71-79	adenosine A2a receptor	Homo sapiens	187-194
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	229-237	catechol-O-methyltransferase	Homo sapiens	25-29
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	229-237	adenosine A2a receptor	Homo sapiens	187-194
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	229-237	catechol-O-methyltransferase	Homo sapiens	25-29
33920292-5	2021	The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect.	Caffeine	229-237	adenosine A2a receptor	Homo sapiens	187-194
33137206-0	2021	CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review.	Caffeine	47-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
33720241-0	2021	Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging.	Caffeine	0-8	telomerase reverse transcriptase	Mus musculus	36-68
33720241-3	2021	In this study, caffeine was found to promote the expression of telomerase reverse transcriptase (TERT) at both mRNA and protein levels, and consequently extended the telomere length and prevented cellular senescence.	Caffeine	15-23	telomerase reverse transcriptase	Mus musculus	63-95
33720241-3	2021	In this study, caffeine was found to promote the expression of telomerase reverse transcriptase (TERT) at both mRNA and protein levels, and consequently extended the telomere length and prevented cellular senescence.	Caffeine	15-23	telomerase reverse transcriptase	Mus musculus	97-101
33720241-4	2021	Knockdown of TERT eliminated the effect of caffeine on telomere elongation.	Caffeine	43-51	telomerase reverse transcriptase	Mus musculus	13-17
33720241-5	2021	Moreover, animal studies indicated that caffeine promoted the expression of TERT and extended the telomere length in the thymus and spleen of mice treated with caffeine for a long period of eight months.	Caffeine	40-48	telomerase reverse transcriptase	Mus musculus	76-80
33720241-5	2021	Moreover, animal studies indicated that caffeine promoted the expression of TERT and extended the telomere length in the thymus and spleen of mice treated with caffeine for a long period of eight months.	Caffeine	160-168	telomerase reverse transcriptase	Mus musculus	76-80
33720241-7	2021	These results suggest that caffeine promotes the expression of TERT to delay cellular senescence and aging, which help to understand the mechanism for the beneficial effects of caffeine containing foods on health.	Caffeine	27-35	telomerase reverse transcriptase	Mus musculus	63-67
33720241-7	2021	These results suggest that caffeine promotes the expression of TERT to delay cellular senescence and aging, which help to understand the mechanism for the beneficial effects of caffeine containing foods on health.	Caffeine	177-185	telomerase reverse transcriptase	Mus musculus	63-67
33137206-1	2021	PURPOSE: To systematically review studies that examined the influence of the CYP1A2 -163C>A polymorphism on the ergogenic effects of caffeine and to discuss some of the reasons for the discrepancies in findings between the studies.	Caffeine	133-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
33137206-10	2021	CONCLUSIONS: CYP1A2 genotype variations may modulate caffeine"s ergogenic effects, but the differences between genotypes were small, inconsistent, or limited to specific exercise scenarios.	Caffeine	53-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
33515564-7	2021	Caffeine induced a smaller increase in [Ca2+]i in both RyR1+/+ and RyR1-/- ASMCs than in PASMCs.	Caffeine	0-8	ryanodine receptor 1, skeletal muscle	Mus musculus	55-59
33515564-7	2021	Caffeine induced a smaller increase in [Ca2+]i in both RyR1+/+ and RyR1-/- ASMCs than in PASMCs.	Caffeine	0-8	ryanodine receptor 1, skeletal muscle	Mus musculus	67-71
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	218-222
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	dynamin 1 like	Homo sapiens	392-417
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	dynamin 1 like	Homo sapiens	419-423
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	76-80
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	258-266	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	76-80
33664417-5	2021	Pharmacological blockade of Drp1 by Mdivi-1 (10 muM) or disturbance of mitochondrial fission by Drp1 silencing markedly suppressed caffeine-induced lamellipodia formation and endothelial cell migration.	Caffeine	131-139	dynamin 1 like	Homo sapiens	28-32
33664417-5	2021	Pharmacological blockade of Drp1 by Mdivi-1 (10 muM) or disturbance of mitochondrial fission by Drp1 silencing markedly suppressed caffeine-induced lamellipodia formation and endothelial cell migration.	Caffeine	131-139	dynamin 1 like	Homo sapiens	96-100
33664417-7	2021	In a mouse model of hindlimb ischemia, administration of caffeine (0.05% in 200 mL drinking water daily, for 14 days) significantly promoted angiogenesis and perfusion as well as activation of endothelial AMPK signaling in the ischemic hindlimb.	Caffeine	57-65	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	205-209
33664417-8	2021	Taken together, caffeine induces mitochondrial fission through cAMP/PKA/AMPK signaling pathway.	Caffeine	16-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76
33531589-1	2021	Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challenge, effects abrogated by the RyR1-antagonist dantrolene which itself increased INa.	Caffeine	234-242	sodium channel, voltage-gated, type IV, alpha	Mus musculus	86-92
33471948-0	2021	Impact of Caffeine on Ethanol Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens.	Caffeine	10-18	mitogen-activated protein kinase 1	Mus musculus	80-83
33471948-0	2021	Impact of Caffeine on Ethanol Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens.	Caffeine	10-18	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	88-96
33471948-3	2021	The present study determined if caffeine can affect locomotion induced by acute and repeated ethanol-administration in adult male CD-1 mice.	Caffeine	32-40	CD1 antigen complex	Mus musculus	130-134
32687613-13	2021	CONCLUSION: A PPK model of caffeine was developed in Chinese newborns.	Caffeine	27-35	kallikrein B1	Homo sapiens	14-17
33403509-3	2021	Substantial variability in the physiological and performance response to acute caffeine consumption is apparent, and a growing number of studies are implicating a single-nucleotide polymorphism in the CYP1A2 gene, responsible for caffeine metabolism, as a key factor that influences the acute responses to caffeine ingestion.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	201-207
33403509-3	2021	Substantial variability in the physiological and performance response to acute caffeine consumption is apparent, and a growing number of studies are implicating a single-nucleotide polymorphism in the CYP1A2 gene, responsible for caffeine metabolism, as a key factor that influences the acute responses to caffeine ingestion.	Caffeine	230-238	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	201-207
33403509-3	2021	Substantial variability in the physiological and performance response to acute caffeine consumption is apparent, and a growing number of studies are implicating a single-nucleotide polymorphism in the CYP1A2 gene, responsible for caffeine metabolism, as a key factor that influences the acute responses to caffeine ingestion.	Caffeine	230-238	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	201-207
33403509-8	2021	More mechanistic and applied research is required to elucidate how the CYP1A2 polymorphism might alter caffeine"s ergogenic effect and the magnitude thereof, and whether CYP1A2 genotyping prior to caffeine supplementation is necessary.	Caffeine	103-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
33531589-1	2021	Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challenge, effects abrogated by the RyR1-antagonist dantrolene which itself increased INa.	Caffeine	234-242	ryanodine receptor 1, skeletal muscle	Mus musculus	152-156
33531589-1	2021	Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challenge, effects abrogated by the RyR1-antagonist dantrolene which itself increased INa.	Caffeine	234-242	ryanodine receptor 1, skeletal muscle	Mus musculus	279-283
32725383-4	2021	RESULTS: Seventy-two metabolic drug interaction studies were identified where volume of distribution at steady-state (Vss) values were available for the CYP index substrates caffeine (CYP1A2), metoprolol (CYP2D6), midazolam (CYP3A4), theophylline (CYP1A2), and tolbutamide (CYP2C9).	Caffeine	174-182	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-156
33045559-5	2021	The presence of caffeine and sulfamethoxazole distribution in tap water was significantly different between landed and high-rise housings (t(152) = -2.298, p = 0.023 and t(109) = 2.135, p = 0.035).	Caffeine	16-24	nuclear RNA export factor 1	Homo sapiens	62-65
33734471-0	2021	Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.	Caffeine	9-17	microRNA 375	Rattus norvegicus	86-92
33734471-0	2021	Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.	Caffeine	9-17	cellular communication network factor 2	Rattus norvegicus	93-97
33734471-9	2021	In vitro, caffeine decreased CTGF and increased miR375 expression in fetal growth plate chondrocytes.	Caffeine	10-18	cellular communication network factor 2	Rattus norvegicus	29-33
33734471-9	2021	In vitro, caffeine decreased CTGF and increased miR375 expression in fetal growth plate chondrocytes.	Caffeine	10-18	microRNA 375	Rattus norvegicus	48-54
33734471-11	2021	Furthermore, CTGF overexpression or miR375 inhibitor reversed caffeine-induced reduction of tube formation ability, and miR375 inhibitor reversed caffeine-induced CTGF expression inhibition.	Caffeine	62-70	cellular communication network factor 2	Rattus norvegicus	13-17
33734471-11	2021	Furthermore, CTGF overexpression or miR375 inhibitor reversed caffeine-induced reduction of tube formation ability, and miR375 inhibitor reversed caffeine-induced CTGF expression inhibition.	Caffeine	146-154	microRNA 375	Rattus norvegicus	120-126
33734471-11	2021	Furthermore, CTGF overexpression or miR375 inhibitor reversed caffeine-induced reduction of tube formation ability, and miR375 inhibitor reversed caffeine-induced CTGF expression inhibition.	Caffeine	146-154	cellular communication network factor 2	Rattus norvegicus	163-167
32930862-7	2021	Moreover, CA and CAF, either alone or combined, completely abolished behavioural changes, and completely protect against changes in thiobarbituric acid reactive substances (TBARS) levels, catalase (CAT) activity and MTT reduction ability, associated with MA or MMA exposure.	Caffeine	17-20	Catalase	Drosophila melanogaster	188-196
32930862-7	2021	Moreover, CA and CAF, either alone or combined, completely abolished behavioural changes, and completely protect against changes in thiobarbituric acid reactive substances (TBARS) levels, catalase (CAT) activity and MTT reduction ability, associated with MA or MMA exposure.	Caffeine	17-20	Catalase	Drosophila melanogaster	198-201
32930862-9	2021	However, CA and CAF (either alone or combined) significantly decreased acetylcholinesterase (AChE) activity per se, while CAF alone protected from changes in AChE activity (in head tissue) associated with MA or MMA.	Caffeine	16-19	Acetylcholine esterase	Drosophila melanogaster	71-91
32930862-9	2021	However, CA and CAF (either alone or combined) significantly decreased acetylcholinesterase (AChE) activity per se, while CAF alone protected from changes in AChE activity (in head tissue) associated with MA or MMA.	Caffeine	16-19	Acetylcholine esterase	Drosophila melanogaster	93-97
33353230-6	2020	Serum alanine aminotransferase (ALT) levels were significantly higher in the caffeine and CGA groups than in the CDAHFD group.	Caffeine	77-85	glutamic pyruvic transaminase, soluble	Mus musculus	6-30
32930862-9	2021	However, CA and CAF (either alone or combined) significantly decreased acetylcholinesterase (AChE) activity per se, while CAF alone protected from changes in AChE activity (in head tissue) associated with MA or MMA.	Caffeine	122-125	Acetylcholine esterase	Drosophila melanogaster	158-162
33490280-2	2021	Methods: We compared the enhanced responsiveness of HEK-293 cells expressing wild-type RYR1 with that of mutant RYR1 to caffeine following perfusion with remimazolam or propofol.	Caffeine	120-128	ryanodine receptor 1	Homo sapiens	112-116
33270240-2	2021	AEG showed antioxidant activity in the DPPH  scavenging (IC50  = 17.00 +- 1.00 microg/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols).	Caffeine	167-175	cysteine-rich secretory protein 3	Rattus norvegicus	0-3
32924205-7	2021	The levels of circulating caffeine in breast cancer patients with luminal A tumors were higher than those in patients with luminal B and HER-2 subtypes.	Caffeine	26-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	137-142
33575270-1	2021	Previous research has identified acute caffeine intake as an effective ergogenic aid to enhance velocity and power during bench press exercise.	Caffeine	39-47	activation induced cytidine deaminase	Homo sapiens	81-84
33420284-2	2021	Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the brain implicated in stimulating BAT thermogenesis.	Caffeine	21-29	hypocretin neuropeptide precursor	Rattus norvegicus	39-45
33420284-7	2021	Caffeine administered both IV and ICV increased neuronal activity, as measured by c-Fos-immunoreactivity within subregions of the hypothalamic area, previously implicated in regulating BAT thermogenesis.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-87
32271938-0	2021	New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.	Caffeine	15-23	corticotropin releasing hormone	Homo sapiens	27-30
32918170-0	2021	Massive beta1-Adrenergic Receptor Reaction Explains Irreversible Acute Arrhythmia in a Fatal Case of Acute Pure Caffeine Intoxication.	Caffeine	112-120	adrenoceptor beta 1	Homo sapiens	8-33
33397254-2	2021	CYP1A2 metabolises many clinical drugs, such as phenacetin, caffeine, clozapine, tacrine, propranolol, and mexiletine.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
33374269-0	2020	Simultaneous Quantification of Antioxidants Paraxanthine and Caffeine in Human Saliva by Electrochemical Sensing for CYP1A2 Phenotyping.	Caffeine	61-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	117-123
33374269-1	2020	The enzyme CYP1A2 is responsible for the metabolism of numerous antioxidants in the body, including caffeine, which is transformed into paraxanthine, its main primary metabolite.	Caffeine	100-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	11-17
33353230-6	2020	Serum alanine aminotransferase (ALT) levels were significantly higher in the caffeine and CGA groups than in the CDAHFD group.	Caffeine	77-85	glutamic pyruvic transaminase, soluble	Mus musculus	32-35
33353230-8	2020	Hepatic expression of interleukin (IL)-6 mRNA was higher in the caffeine and CGA groups than in the CDAHFD group, and the difference was statistically significant for the caffeine group.	Caffeine	64-72	interleukin 6	Mus musculus	22-40
33353230-8	2020	Hepatic expression of interleukin (IL)-6 mRNA was higher in the caffeine and CGA groups than in the CDAHFD group, and the difference was statistically significant for the caffeine group.	Caffeine	171-179	interleukin 6	Mus musculus	22-40
33390888-5	2020	In addition, animal studies have also demonstrated that caffeine confers neuroprotection against dopaminergic neurodegeneration using PD models of mitochondrial toxins (MPTP, 6-OHDA, and rotenone) and expression of alpha-synuclein (alpha-Syn).	Caffeine	56-64	synuclein alpha	Homo sapiens	215-230
33390888-5	2020	In addition, animal studies have also demonstrated that caffeine confers neuroprotection against dopaminergic neurodegeneration using PD models of mitochondrial toxins (MPTP, 6-OHDA, and rotenone) and expression of alpha-synuclein (alpha-Syn).	Caffeine	56-64	synuclein alpha	Homo sapiens	232-241
33390888-6	2020	While caffeine has complex pharmacological profiles, studies with genetic knockout mice have clearly revealed that caffeine"s action is largely mediated by the brain adenosine A2A receptor (A2AR) and confer neuroprotection by modulating neuroinflammation and excitotoxicity and mitochondrial function.	Caffeine	115-123	adenosine A2a receptor	Mus musculus	190-194
33390888-7	2020	Interestingly, recent studies have highlighted emerging new mechanisms including caffeine modulation of alpha-Syn degradation with enhanced autophagy and caffeine modulation of gut microbiota and gut-brain axis in PD models.	Caffeine	81-89	synemin	Homo sapiens	110-113
33339359-6	2020	Consumption of CAF resulted in a 25% increase in glucose and a 26% increase in insulin area under the curve (AUC, p = 0.037; p < 0.0001) compared to DECAF.	Caffeine	15-18	insulin	Homo sapiens	79-86
33115721-7	2020	Focusing on transcription, we found that hrq1 mutant cells are sensitive to caffeine and that mutation of HRQ1 alters the expression levels of hundreds of genes.	Caffeine	76-84	ATP-dependent 3'-5' DNA helicase	Saccharomyces cerevisiae S288C	41-45
33552855-3	2021	This CID tool, evolved from an anti-caffeine nanobody via cell-based high-throughput screening, permits caffeine-inducible gating of calcium channels, tumor killing via necroptosis, growth factors-independent activation of tyrosine receptor kinase signaling, and enhancement of nanobody-mediated antigen recognition for the severe acute respiratory distress coronavirus 2 (SARS-CoV-2) spike protein.	Caffeine	36-44	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	385-390
33552855-3	2021	This CID tool, evolved from an anti-caffeine nanobody via cell-based high-throughput screening, permits caffeine-inducible gating of calcium channels, tumor killing via necroptosis, growth factors-independent activation of tyrosine receptor kinase signaling, and enhancement of nanobody-mediated antigen recognition for the severe acute respiratory distress coronavirus 2 (SARS-CoV-2) spike protein.	Caffeine	104-112	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	385-390
32999056-0	2020	Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study.	Caffeine	15-23	leucine rich repeat kinase 2	Homo sapiens	88-93
32999056-4	2020	RESULTS: Plasma caffeine concentration was lower in patients with PD vs UC (p < 0.001), more so among LRRK2+ carriers (by 76%) than among LRRK2- participants (by 31%), with significant interaction between LRRK2 and PD status (p = 0.005).	Caffeine	16-24	leucine rich repeat kinase 2	Homo sapiens	102-107
32999056-6	2020	Dietary caffeine was also lower in LRRK2+/PD+ compared to LRRK2+/UC with significant interaction effect with the LRRK2+ mutation (p < 0.001).	Caffeine	8-16	leucine rich repeat kinase 2	Homo sapiens	35-40
32999056-6	2020	Dietary caffeine was also lower in LRRK2+/PD+ compared to LRRK2+/UC with significant interaction effect with the LRRK2+ mutation (p < 0.001).	Caffeine	8-16	leucine rich repeat kinase 2	Homo sapiens	58-63
32999056-6	2020	Dietary caffeine was also lower in LRRK2+/PD+ compared to LRRK2+/UC with significant interaction effect with the LRRK2+ mutation (p < 0.001).	Caffeine	8-16	leucine rich repeat kinase 2	Homo sapiens	58-63
33302490-0	2020	A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine.	Caffeine	234-242	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-89
33302490-0	2020	A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine.	Caffeine	234-242	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	94-101
32916273-8	2020	In 1202 women with available data, maternal caffeine use was associated with an increased risk of low AMH, compared to normal (relative risk [RR] 1.90, 95% confidence interval [CI] 1.09, 3.30).	Caffeine	44-52	anti-Mullerian hormone	Homo sapiens	102-105
32279279-3	2020	METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC.	Caffeine	95-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-74
32279279-3	2020	METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC.	Caffeine	95-103	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	191-198
32279279-3	2020	METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC.	Caffeine	95-103	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	227-233
32279279-3	2020	METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC.	Caffeine	95-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	271-277
33101488-5	2020	Subsequently, the results demonstrated that the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) inhibitors wortmannin and caffeine had no effect on the cell cycle; however, the inhibitors partially abrogated 2,3-DCPE-induced S phase arrest.	Caffeine	159-167	ATM serine/threonine kinase	Homo sapiens	48-77
33101488-5	2020	Subsequently, the results demonstrated that the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) inhibitors wortmannin and caffeine had no effect on the cell cycle; however, the inhibitors partially abrogated 2,3-DCPE-induced S phase arrest.	Caffeine	159-167	ATM serine/threonine kinase	Homo sapiens	79-82
33101488-7	2020	Furthermore, wortmannin and caffeine inhibited the 2,3-DCPE-mediated phosphorylation of Chk1 and the degradation of Cdc25A.	Caffeine	28-36	checkpoint kinase 1	Homo sapiens	88-92
33101488-7	2020	Furthermore, wortmannin and caffeine inhibited the 2,3-DCPE-mediated phosphorylation of Chk1 and the degradation of Cdc25A.	Caffeine	28-36	cell division cycle 25A	Homo sapiens	116-122
33025424-0	2020	Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmission at the hippocampus.	Caffeine	0-8	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	33-46
33025424-4	2020	We thus aimed to elucidate the effects of caffeine upon NMDAR-mediated excitatory post-synaptic currents (NMDAR-EPSCs), and its implications upon neuronal Ca2+ homeostasis.	Caffeine	42-50	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	56-61
33025424-4	2020	We thus aimed to elucidate the effects of caffeine upon NMDAR-mediated excitatory post-synaptic currents (NMDAR-EPSCs), and its implications upon neuronal Ca2+ homeostasis.	Caffeine	42-50	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	106-111
33025424-5	2020	We found that caffeine (30-200 muM) facilitates NMDAR-EPSCs on pyramidal CA1 neurons from Balbc/ByJ male mice, an action mimicked, as well as occluded, by 1,3-dipropyl-cyclopentylxantine (DPCPX, 50 nM), thus likely mediated by blockade of inhibitory A1Rs.	Caffeine	14-22	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	48-53
33025424-7	2020	Adenosine A2ARs are involved in this likely pre-synaptic action since the effect of caffeine was mimicked by the A2AR antagonist, SCH58261 (50 nM).	Caffeine	84-92	adenosine A2a receptor	Mus musculus	10-14
33025424-8	2020	Furthermore, caffeine increased the frequency of Ca2+ transients in neuronal cell culture, an action mimicked by the A1R antagonist, DPCPX, and prevented by NMDAR blockade with AP5 (50 muM).	Caffeine	13-21	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	157-162
33177647-3	2020	The results obtained showed that coffee decoction down-regulated the expression of ERalpha, which was attributed to caffeine inhibiting its transcription.	Caffeine	116-124	estrogen receptor 1	Homo sapiens	83-90
33025424-9	2020	Altogether, these results show for the first time an influence of caffeine on NMDA receptor activity at the hippocampus, with impact in neuronal Ca2+ homeostasis.	Caffeine	66-74	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	78-91
33255240-10	2020	The results also showed that there was a dose-response effect of caffeine on the fat oxidation rate, indicating that more than 3.0 mg/kg is necessary to obtain a statistically significant effect of this stimulant on fat oxidation during exercise.	Caffeine	65-73	FAT atypical cadherin 1	Homo sapiens	216-219
33255240-11	2020	Additionally, the ability of caffeine to enhance fat oxidation during exercise was higher in sedentary or untrained individuals than in trained and recreational athletes.	Caffeine	29-37	FAT atypical cadherin 1	Homo sapiens	49-52
33255240-12	2020	In conclusion, pre-exercise intake of a moderate dose of caffeine may effectively increase fat utilization during aerobic exercise of submaximal intensity performed after a fasting period.	Caffeine	57-65	FAT atypical cadherin 1	Homo sapiens	91-94
33255240-13	2020	However, the fitness level of the participant may modulate the magnitude of the effect of caffeine on fat oxidation during exercise.	Caffeine	90-98	FAT atypical cadherin 1	Homo sapiens	102-105
33255240-0	2020	Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis.	Caffeine	16-24	FAT atypical cadherin 1	Homo sapiens	39-42
33255240-1	2020	A number of previous investigations have been designed to determine the effect of acute caffeine intake on the rate of fat oxidation during exercise.	Caffeine	88-96	FAT atypical cadherin 1	Homo sapiens	119-122
33255240-4	2020	The purpose of this study was to conduct a systematic review followed by a meta-analysis to establish the effect of acute intake of caffeine (ranging from 2 to 7 mg/kg of body mass) on the rate of fat oxidation during exercise.	Caffeine	132-140	FAT atypical cadherin 1	Homo sapiens	197-200
33255240-8	2020	The meta-analysis revealed that caffeine significantly (p = 0.008) increased the fat oxidation rate (SMD = 0.73; 95% CI = 0.19 to 1.27).	Caffeine	32-40	FAT atypical cadherin 1	Homo sapiens	81-84
33255240-10	2020	The results also showed that there was a dose-response effect of caffeine on the fat oxidation rate, indicating that more than 3.0 mg/kg is necessary to obtain a statistically significant effect of this stimulant on fat oxidation during exercise.	Caffeine	65-73	FAT atypical cadherin 1	Homo sapiens	81-84
32878990-7	2020	Mutating the Ca2+ activation site markedly reduced the sensitivity of RyR2 to Ca2+ and caffeine activation.	Caffeine	87-95	ryanodine receptor 2	Homo sapiens	70-74
32878990-11	2020	Furthermore, disease-associated RyR2 mutations within the central domain significantly enhanced Ca2+ and caffeine activation and reduced Mg2+ inhibition.	Caffeine	105-113	ryanodine receptor 2	Homo sapiens	32-36
33170731-1	2021	The aim of this study was to investigate the influence of ADORA2A and CYP1A2 genotypes on the physiological and ergogenic effects of caffeine.	Caffeine	133-141	adenosine A2a receptor	Homo sapiens	58-65
33170731-1	2021	The aim of this study was to investigate the influence of ADORA2A and CYP1A2 genotypes on the physiological and ergogenic effects of caffeine.	Caffeine	133-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
33177647-6	2020	The activation of p53 through the cooperative effects of these unidentified component(s), caffeine, and tamoxifen appeared to be due to the suppression of the ERK and Akt pathways.	Caffeine	90-98	tumor protein p53	Homo sapiens	18-21
33177647-6	2020	The activation of p53 through the cooperative effects of these unidentified component(s), caffeine, and tamoxifen appeared to be due to the suppression of the ERK and Akt pathways.	Caffeine	90-98	mitogen-activated protein kinase 1	Homo sapiens	159-162
33177647-6	2020	The activation of p53 through the cooperative effects of these unidentified component(s), caffeine, and tamoxifen appeared to be due to the suppression of the ERK and Akt pathways.	Caffeine	90-98	AKT serine/threonine kinase 1	Homo sapiens	167-170
33143619-7	2021	Unexpectedly, we found that caffeine can fight WARS by acting on multiple organs, which may lead to prevent the virus from entering the cell, stimulate the phagocytosis of macrophages, enhance breathing, and inhibit the cytokine storm.	Caffeine	28-36	tryptophanyl-tRNA synthetase 1	Homo sapiens	47-51
33143619-9	2021	Collectively, we report that caffeine, an FDA-approved, highly safe, inexpensive, and widely available drug, could be an excellent HDT for battling WARS.	Caffeine	29-37	tryptophanyl-tRNA synthetase 1	Homo sapiens	148-152
33143619-0	2021	Rediscovery of caffeine: an excellent drug for improving patient outcomes while fighting WARS.	Caffeine	15-23	tryptophanyl-tRNA synthetase 1	Homo sapiens	89-93
32941854-7	2020	CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	88-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
32894766-6	2020	Acute treatment with 10 microM DDx failed to induce Ca2+ release in HEK293-RyR2, whereas pre-treatment with DDx (0.1-10 microM) for 12- or 24-h significantly decreased SR Ca2+ stores in HEK-RyR2 cells challenged with caffeine (1 mM), an RyR agonist.	Caffeine	217-225	aldo-keto reductase family 1 member C3	Homo sapiens	108-111
33349580-1	2020	The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide.	Caffeine	48-56	adenosine A2a receptor	Homo sapiens	4-26
32941854-7	2020	CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	88-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-67
32941854-11	2020	The presented findings may have clinical implications for the prediction of potential drug-drug interactions involving the asenapine-induced inhibition of metabolism of CYP1A2 substrates (e.g. caffeine, theophylline, melatonin, tricyclic antidepressants, phenacetin, propranolol) and iloperidone-induced inhibition of CYP3A4 substrates (e.g. antidepressants, benzodiazepines, atorvastatin, macrolide antibiotics, calcium channel antagonists).	Caffeine	193-201	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	169-175
33080900-7	2020	Our MD simulations suggest that the combination of caffeine with ribavirin shows a stronger interaction with 6VW1, while in case of favipiravir+nicotine, 6LZG shows potent efficacy of these interaction, proposing the potent efficacy of these combinations for blocking ACE2 receptor against SARS-CoV-2.	Caffeine	51-59	angiotensin converting enzyme 2	Homo sapiens	268-272
33124749-9	2021	CONCLUSION: Peroral caffeine consumption significantly decreased UVR-induced apoptosis in LEC supporting epidemiological findings that caffeine delays the onset of cataract.	Caffeine	20-28	C-C motif chemokine ligand 16	Homo sapiens	90-93
33124749-9	2021	CONCLUSION: Peroral caffeine consumption significantly decreased UVR-induced apoptosis in LEC supporting epidemiological findings that caffeine delays the onset of cataract.	Caffeine	135-143	C-C motif chemokine ligand 16	Homo sapiens	90-93
33143181-5	2020	In addition, mitochondrial activity decreased and mitochondrial morphology was disrupted, and the expression of oxidative stress response genes, hsp-6, gst-4, and daf-16, was induced by caffeine intake.	Caffeine	186-194	Heat shock protein hsp-6	Caenorhabditis elegans	145-150
33143181-5	2020	In addition, mitochondrial activity decreased and mitochondrial morphology was disrupted, and the expression of oxidative stress response genes, hsp-6, gst-4, and daf-16, was induced by caffeine intake.	Caffeine	186-194	Glutathione S-transferase 4	Caenorhabditis elegans	152-157
33143181-5	2020	In addition, mitochondrial activity decreased and mitochondrial morphology was disrupted, and the expression of oxidative stress response genes, hsp-6, gst-4, and daf-16, was induced by caffeine intake.	Caffeine	186-194	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	163-169
33143181-6	2020	Furthermore, the level of an energy metabolism sensor, phospho-AMP-activated protein kinase, was increased, whereas the expression of the sterol regulatory element binding protein gene and its target stearoyl-CoA desaturase genes, fat-5, -6, and -7, was decreased with caffeine intake.	Caffeine	269-277	BHLH domain-containing protein	Caenorhabditis elegans	138-179
33143181-6	2020	Furthermore, the level of an energy metabolism sensor, phospho-AMP-activated protein kinase, was increased, whereas the expression of the sterol regulatory element binding protein gene and its target stearoyl-CoA desaturase genes, fat-5, -6, and -7, was decreased with caffeine intake.	Caffeine	269-277	Delta(9)-fatty-acid desaturase fat-5	Caenorhabditis elegans	231-248
33080900-0	2020	In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor.	Caffeine	59-67	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	84-85
31658882-1	2020	As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens.	Caffeine	107-115	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41
33080900-0	2020	In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor.	Caffeine	59-67	angiotensin converting enzyme 2	Homo sapiens	115-119
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Caffeine	158-166	angiotensin converting enzyme 2	Homo sapiens	55-86
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Caffeine	158-166	angiotensin converting enzyme 2	Homo sapiens	88-92
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	angiotensin converting enzyme 2	Homo sapiens	49-53
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	102-107
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-110
33080900-3	2020	We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations.	Caffeine	236-244	angiotensin converting enzyme 2	Homo sapiens	56-60
33080900-3	2020	We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations.	Caffeine	236-244	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	61-62
33080900-5	2020	Our results reveal that caffeine or nicotine in a specific molar ratio to 6LZG shows a very strong interaction and indicate that caffeine is more efficient in the interaction with 6LZG and further blocking of this site against S protein binding.	Caffeine	24-32	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-228
33080900-5	2020	Our results reveal that caffeine or nicotine in a specific molar ratio to 6LZG shows a very strong interaction and indicate that caffeine is more efficient in the interaction with 6LZG and further blocking of this site against S protein binding.	Caffeine	129-137	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-228
32818735-2	2020	The degradation of bisphenol A, diclofenac and caffeine was predominantly contributed by chlorination (>60%), direct UV photolysis (>80%) and radical oxidation (>90%), respectively, during the treatment by the UV-LED/chlorine AOP at three tested UV wavelengths (i.e., 265, 285 and 300 nm).	Caffeine	47-55	small integral membrane protein 10 like 2A	Homo sapiens	213-216
32535660-6	2020	RESULTS: In functional analysis using HEK-293 cells, we found significant reductions in the EC50 of p.Ser2345Thr and p.Ser2345Arg in comparison with wild-type RYR1 (P < 0.001), while the EC50 of p.Lys3367Arg was not significantly different (P = 0.062 for caffeine and P > 0.999 for 4CmC).	Caffeine	255-263	ryanodine receptor 1	Homo sapiens	159-163
33123534-0	2020	Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation.	Caffeine	0-8	glucose-6-phosphate dehydrogenase	Homo sapiens	17-22
33123534-3	2020	Here, we report a previously unknown biochemical mechanism through which caffeine, a well-known natural small molecule, regulates G6PDH activity to disrupt cellular redox homeostasis and suppress RCC development and progression.	Caffeine	73-81	glucose-6-phosphate dehydrogenase	Homo sapiens	130-135
33123534-4	2020	We found that caffeine can inhibit G6PDH enzymatic activity.	Caffeine	14-22	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
33123534-5	2020	Mechanistically, caffeine directly binds to G6PDH with high affinity (K D = 0.1923 muM) and competes with the coenzyme NADP+ for G6PDH binding, as demonstrated by the decreased binding affinities of G6PDH for its coenzyme and substrate.	Caffeine	17-25	glucose-6-phosphate dehydrogenase	Homo sapiens	44-49
33123534-5	2020	Mechanistically, caffeine directly binds to G6PDH with high affinity (K D = 0.1923 muM) and competes with the coenzyme NADP+ for G6PDH binding, as demonstrated by the decreased binding affinities of G6PDH for its coenzyme and substrate.	Caffeine	17-25	glucose-6-phosphate dehydrogenase	Homo sapiens	129-134
33123534-5	2020	Mechanistically, caffeine directly binds to G6PDH with high affinity (K D = 0.1923 muM) and competes with the coenzyme NADP+ for G6PDH binding, as demonstrated by the decreased binding affinities of G6PDH for its coenzyme and substrate.	Caffeine	17-25	glucose-6-phosphate dehydrogenase	Homo sapiens	129-134
33123534-6	2020	Molecular docking studies revealed that caffeine binds to G6PDH at the structural NADP+ binding site, and chemical cross-linking analysis demonstrated that caffeine inhibits the formation of dimeric G6PDH.	Caffeine	40-48	glucose-6-phosphate dehydrogenase	Homo sapiens	58-63
33123534-6	2020	Molecular docking studies revealed that caffeine binds to G6PDH at the structural NADP+ binding site, and chemical cross-linking analysis demonstrated that caffeine inhibits the formation of dimeric G6PDH.	Caffeine	40-48	glucose-6-phosphate dehydrogenase	Homo sapiens	199-204
33123534-6	2020	Molecular docking studies revealed that caffeine binds to G6PDH at the structural NADP+ binding site, and chemical cross-linking analysis demonstrated that caffeine inhibits the formation of dimeric G6PDH.	Caffeine	156-164	glucose-6-phosphate dehydrogenase	Homo sapiens	199-204
33123534-7	2020	G6PDH inhibition abrogated the inhibitory effects of caffeine on RCC cell growth.	Caffeine	53-61	glucose-6-phosphate dehydrogenase	Homo sapiens	0-5
33123534-8	2020	Moreover, inhibition of G6PDH activity by caffeine led to a reduction in the intracellular levels of NADPH and reactive oxygen species (ROS), and altered the expression of redox-related proteins in RCC cells.	Caffeine	42-50	glucose-6-phosphate dehydrogenase	Homo sapiens	24-29
33123534-9	2020	Accordingly, caffeine could inhibit tumor growth through inhibition of G6PDH activity in vivo.	Caffeine	13-21	glucose-6-phosphate dehydrogenase	Homo sapiens	71-76
33123534-10	2020	Taken together, these results demonstrated that caffeine can target G6PDH to disrupt redox homeostasis and inhibit RCC tumor growth, and has potential as a therapeutic agent for the treatment of RCC.	Caffeine	48-56	glucose-6-phosphate dehydrogenase	Homo sapiens	68-73
32757222-0	2020	The low-expression programming of 11beta-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.	Caffeine	103-111	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	34-45
31658882-1	2020	As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens.	Caffeine	107-115	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46
31658882-1	2020	As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens.	Caffeine	107-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69
32703116-15	2020	Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003).	Caffeine	66-74	interferon gamma	Homo sapiens	106-114
32703116-15	2020	Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003).	Caffeine	191-199	interferon gamma	Homo sapiens	106-114
32703116-15	2020	Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003).	Caffeine	191-199	interferon alpha 1	Homo sapiens	229-237
32703116-15	2020	Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003).	Caffeine	191-199	interleukin 17A	Homo sapiens	250-255
32703116-15	2020	Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003).	Caffeine	191-199	interleukin 6	Homo sapiens	271-275
32652892-9	2020	Finally, caffeine-induced increase in adiponectin in turn upregulated hepatic HNF-4alpha levels in human SHBG transgenic mice.	Caffeine	9-17	hepatocyte nuclear factor 4 alpha	Homo sapiens	78-88
32764093-2	2020	Dietary caffeine (CAF) is the most commonly consumed psychoactive compound by humans.	Caffeine	8-16	caffeine susceptibility	Mus musculus	18-21
32971922-7	2020	Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of alpha-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	59-81
32971922-7	2020	Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of alpha-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.	Caffeine	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	152-176
32971922-7	2020	Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of alpha-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.	Caffeine	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	178-183
32971922-7	2020	Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of alpha-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.	Caffeine	0-8	synuclein alpha	Homo sapiens	323-338
32971922-7	2020	Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of alpha-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.	Caffeine	0-8	microtubule associated protein tau	Homo sapiens	349-352
32932231-1	2020	This study aimed to identify the acute effects of caffeinated chewing gum (CAF) on bicycle motocross (BMX) time-trial (TT) performance.	Caffeine	75-78	BMX non-receptor tyrosine kinase	Homo sapiens	102-105
32932231-7	2020	BMX coaches and riders may consider consuming CAF before a BMX race to improve performance and reduce rating of perceived exertion.	Caffeine	46-49	BMX non-receptor tyrosine kinase	Homo sapiens	0-3
32907591-0	2020	Caffeine supplementation induces higher IL-6 and IL-10 plasma levels in response to a treadmill exercise test.	Caffeine	0-8	interleukin 6	Homo sapiens	40-44
32907591-0	2020	Caffeine supplementation induces higher IL-6 and IL-10 plasma levels in response to a treadmill exercise test.	Caffeine	0-8	interleukin 10	Homo sapiens	49-54
32907591-3	2020	The aim of this study was to determine the effects of caffeine supplementation on plasma levels of cytokines, mainly IL-10 and IL-6, in response to exercise.	Caffeine	54-62	interleukin 10	Homo sapiens	117-122
32907591-3	2020	The aim of this study was to determine the effects of caffeine supplementation on plasma levels of cytokines, mainly IL-10 and IL-6, in response to exercise.	Caffeine	54-62	interleukin 6	Homo sapiens	127-131
32907591-11	2020	Caffeine supplementation influenced only IL-6 (3.04 +- 0.40 vs. 3.89 +- 0.62 pg mL- 1, p = 0.003) and IL-10 (2.42 +- 0.54 vs. 3.47 +- 0.72 pg mL- 1, p = 0.01) levels, with higher concentrations after exercise in the supplemented condition.	Caffeine	0-8	interleukin 6	Homo sapiens	41-45
32907591-11	2020	Caffeine supplementation influenced only IL-6 (3.04 +- 0.40 vs. 3.89 +- 0.62 pg mL- 1, p = 0.003) and IL-10 (2.42 +- 0.54 vs. 3.47 +- 0.72 pg mL- 1, p = 0.01) levels, with higher concentrations after exercise in the supplemented condition.	Caffeine	0-8	interleukin 10	Homo sapiens	102-107
32907591-13	2020	CONCLUSIONS: The results of the present study indicate a significant influence of caffeine supplementation increasing the response to exercise of two essential cytokines such as IL-6 and IL-10.	Caffeine	82-90	interleukin 6	Homo sapiens	178-182
32907591-13	2020	CONCLUSIONS: The results of the present study indicate a significant influence of caffeine supplementation increasing the response to exercise of two essential cytokines such as IL-6 and IL-10.	Caffeine	82-90	interleukin 10	Homo sapiens	187-192
32011181-4	2020	Caffeine consumption induced a statistically significant dilator effect on pupil size (p = 0.011, eta2 = 0.271), and reduced variability of accommodative response (p = 0.027, eta2 = 0.211).	Caffeine	0-8	DNA polymerase iota	Homo sapiens	98-102
32011181-4	2020	Caffeine consumption induced a statistically significant dilator effect on pupil size (p = 0.011, eta2 = 0.271), and reduced variability of accommodative response (p = 0.027, eta2 = 0.211).	Caffeine	0-8	DNA polymerase iota	Homo sapiens	175-179
33015038-10	2020	Taken together, our results show that caffeine targets SIRT3 to enhance SOD2 activity and protect skin cells from UV irradiation-induced oxidative stress.	Caffeine	38-46	sirtuin 3	Homo sapiens	55-60
33015038-10	2020	Taken together, our results show that caffeine targets SIRT3 to enhance SOD2 activity and protect skin cells from UV irradiation-induced oxidative stress.	Caffeine	38-46	superoxide dismutase 2	Homo sapiens	72-76
33015038-11	2020	Thus, caffeine, as a small-molecule SIRT3 activator, could be a potential agent to protect human skin against UV radiation.	Caffeine	6-14	sirtuin 3	Homo sapiens	36-41
32424513-4	2020	The CYP1A2 rs762551 and ADORA2A rs5760423 variants have been previously marginally associated with the risk of PD and are also implicated in caffeine metabolism pathways.	Caffeine	141-149	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
32424513-4	2020	The CYP1A2 rs762551 and ADORA2A rs5760423 variants have been previously marginally associated with the risk of PD and are also implicated in caffeine metabolism pathways.	Caffeine	141-149	adenosine A2a receptor	Homo sapiens	24-31
32652892-0	2020	Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue.	Caffeine	0-8	sex hormone binding globulin	Homo sapiens	29-57
32652892-0	2020	Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue.	Caffeine	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	83-94
32652892-0	2020	Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	103-106
32652892-0	2020	Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue.	Caffeine	0-8	forkhead box O1	Homo sapiens	107-112
32652892-1	2020	SCOPE: Epidemiological studies have shown that caffeine increases serum sex hormone-binding globulin (SHBG) levels.	Caffeine	47-55	sex hormone binding globulin	Homo sapiens	72-100
32652892-1	2020	SCOPE: Epidemiological studies have shown that caffeine increases serum sex hormone-binding globulin (SHBG) levels.	Caffeine	47-55	sex hormone binding globulin	Homo sapiens	102-106
32652892-2	2020	The relationship between caffeine and SHBG production has never been studied before at molecular level.	Caffeine	25-33	sex hormone binding globulin	Homo sapiens	38-42
32652892-3	2020	The aim of our study was to examine whether caffeine regulates SHBG production and to determine the associated molecular mechanisms.	Caffeine	44-52	sex hormone binding globulin	Homo sapiens	63-67
32652892-6	2020	By contrast, caffeine treatment increased significantly hepatic SHBG production in human SHBG transgenic mice when compared with control mice.	Caffeine	13-21	sex hormone binding globulin	Homo sapiens	64-68
32652892-6	2020	By contrast, caffeine treatment increased significantly hepatic SHBG production in human SHBG transgenic mice when compared with control mice.	Caffeine	13-21	sex hormone binding globulin	Homo sapiens	89-93
32652892-7	2020	Caffeine increased adiponectin levels in epididymal adipose tissue of human SHBG transgenic mice.	Caffeine	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	19-30
32652892-7	2020	Caffeine increased adiponectin levels in epididymal adipose tissue of human SHBG transgenic mice.	Caffeine	0-8	sex hormone binding globulin	Homo sapiens	76-80
32538495-1	2020	The purpose of this study was to investigate whether variations in 163 C>A CYP1A2 genotypes (rs 762551) (AA, AC and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility and endurance in adolescent athletes.	Caffeine	152-160	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81
32538495-1	2020	The purpose of this study was to investigate whether variations in 163 C>A CYP1A2 genotypes (rs 762551) (AA, AC and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility and endurance in adolescent athletes.	Caffeine	162-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81
32971922-0	2020	Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer"s and Parkinson"s Disease: Insight into the Role of Nrf-2 and A2AR Signaling.	Caffeine	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	122-127
32971922-0	2020	Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer"s and Parkinson"s Disease: Insight into the Role of Nrf-2 and A2AR Signaling.	Caffeine	43-51	adenosine A2a receptor	Homo sapiens	132-136
32971922-3	2020	According to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine A2A, thereby regulating the accumulation of Abeta; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as alpha-synuclein, in Alzheimer"s and Parkinson"s diseases.	Caffeine	45-53	amyloid beta precursor protein	Homo sapiens	176-181
32971922-3	2020	According to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine A2A, thereby regulating the accumulation of Abeta; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as alpha-synuclein, in Alzheimer"s and Parkinson"s diseases.	Caffeine	45-53	microtubule associated protein tau	Homo sapiens	218-221
32971922-3	2020	According to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine A2A, thereby regulating the accumulation of Abeta; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as alpha-synuclein, in Alzheimer"s and Parkinson"s diseases.	Caffeine	45-53	synuclein alpha	Homo sapiens	282-297
32580047-0	2020	Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of alpha-tubulin acetylation.	Caffeine	0-8	tubulin alpha 1b	Homo sapiens	79-92
32580047-3	2020	Here, we investigated whether caffeine inhibits the antitumor activity of paclitaxel via down-regulation of alpha-tubulin acetylation.	Caffeine	30-38	tubulin alpha 1b	Homo sapiens	108-121
32580047-7	2020	Additionally, caffeine enhanced migration ability, inhibited apoptosis, and decreased the acetylation of alpha-tubulin in paclitaxel-treated cancer cells.	Caffeine	14-22	tubulin alpha 1b	Homo sapiens	105-118
32580047-8	2020	Furthermore, caffeine decreased the inhibitory effect of paclitaxel on tumor growth through down-regulation of alpha-tubulin acetylation in vivo.	Caffeine	13-21	tubulin alpha 1b	Homo sapiens	111-124
32580047-9	2020	Taken together, these findings demonstrate that caffeine inhibits the anticancer activity of paclitaxel via down-regulation of alpha-tubulin acetylation, suggesting that patients receiving treatment with taxanes, such as paclitaxel, should avoid consuming caffeinated beverages or foods.	Caffeine	48-56	tubulin alpha 1b	Homo sapiens	127-140
32559871-5	2020	Metoprolol (524 ng L-1), caffeine (390 ng L-1) and acetaminophen (156 ng L-1) were the three most abundant non-antibiotics with the highest median concentration, and nalidixic acid (135 ng L-1), erythromycin (64 ng L-1) and sulfamethoxazole (77 ng L-1) were the most abundant antibiotics.	Caffeine	25-33	L1 cell adhesion molecule	Homo sapiens	42-45
32559871-5	2020	Metoprolol (524 ng L-1), caffeine (390 ng L-1) and acetaminophen (156 ng L-1) were the three most abundant non-antibiotics with the highest median concentration, and nalidixic acid (135 ng L-1), erythromycin (64 ng L-1) and sulfamethoxazole (77 ng L-1) were the most abundant antibiotics.	Caffeine	25-33	L1 cell adhesion molecule	Homo sapiens	42-45
32559871-5	2020	Metoprolol (524 ng L-1), caffeine (390 ng L-1) and acetaminophen (156 ng L-1) were the three most abundant non-antibiotics with the highest median concentration, and nalidixic acid (135 ng L-1), erythromycin (64 ng L-1) and sulfamethoxazole (77 ng L-1) were the most abundant antibiotics.	Caffeine	25-33	L1 cell adhesion molecule	Homo sapiens	42-45
32559871-5	2020	Metoprolol (524 ng L-1), caffeine (390 ng L-1) and acetaminophen (156 ng L-1) were the three most abundant non-antibiotics with the highest median concentration, and nalidixic acid (135 ng L-1), erythromycin (64 ng L-1) and sulfamethoxazole (77 ng L-1) were the most abundant antibiotics.	Caffeine	25-33	L1 cell adhesion molecule	Homo sapiens	42-45
32559871-5	2020	Metoprolol (524 ng L-1), caffeine (390 ng L-1) and acetaminophen (156 ng L-1) were the three most abundant non-antibiotics with the highest median concentration, and nalidixic acid (135 ng L-1), erythromycin (64 ng L-1) and sulfamethoxazole (77 ng L-1) were the most abundant antibiotics.	Caffeine	25-33	L1 cell adhesion molecule	Homo sapiens	42-45
33015038-0	2020	Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria.	Caffeine	0-8	sirtuin 3	Homo sapiens	17-22
33015038-0	2020	Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria.	Caffeine	0-8	superoxide dismutase 2	Homo sapiens	34-38
33015038-5	2020	In this study, we investigated whether the antioxidant effect of caffeine involves modulation of SOD2 by SIRT3 using in vitro and in vivo models.	Caffeine	65-73	superoxide dismutase 2	Homo sapiens	97-101
33015038-5	2020	In this study, we investigated whether the antioxidant effect of caffeine involves modulation of SOD2 by SIRT3 using in vitro and in vivo models.	Caffeine	65-73	sirtuin 3	Homo sapiens	105-110
33015038-6	2020	The results show that caffeine interacts with SIRT3 and promotes direct binding of SIRT3 with its substrate, thereby enhancing its enzymatic activity.	Caffeine	22-30	sirtuin 3	Homo sapiens	46-51
33015038-6	2020	The results show that caffeine interacts with SIRT3 and promotes direct binding of SIRT3 with its substrate, thereby enhancing its enzymatic activity.	Caffeine	22-30	sirtuin 3	Homo sapiens	83-88
33015038-7	2020	Mechanistically, caffeine bound to SIRT3 with high affinity (K D = 6.858 x 10-7 M); the binding affinity between SIRT3 and its substrate acetylated p53 was also 9.03 (without NAD+) or 6.87 (with NAD+) times higher in the presence of caffeine.	Caffeine	17-25	sirtuin 3	Homo sapiens	35-40
33015038-7	2020	Mechanistically, caffeine bound to SIRT3 with high affinity (K D = 6.858 x 10-7 M); the binding affinity between SIRT3 and its substrate acetylated p53 was also 9.03 (without NAD+) or 6.87 (with NAD+) times higher in the presence of caffeine.	Caffeine	17-25	tumor protein p53	Homo sapiens	148-151
33015038-7	2020	Mechanistically, caffeine bound to SIRT3 with high affinity (K D = 6.858 x 10-7 M); the binding affinity between SIRT3 and its substrate acetylated p53 was also 9.03 (without NAD+) or 6.87 (with NAD+) times higher in the presence of caffeine.	Caffeine	233-241	sirtuin 3	Homo sapiens	113-118
33015038-9	2020	More importantly, caffeine enhanced SIRT3 activity and reduced SOD2 acetylation, thereby leading to increased SOD2 activity, which could be reversed by treatment with the SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) in vitro and in vivo.	Caffeine	18-26	sirtuin 3	Homo sapiens	36-41
33015038-9	2020	More importantly, caffeine enhanced SIRT3 activity and reduced SOD2 acetylation, thereby leading to increased SOD2 activity, which could be reversed by treatment with the SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) in vitro and in vivo.	Caffeine	18-26	superoxide dismutase 2	Homo sapiens	63-67
33015038-9	2020	More importantly, caffeine enhanced SIRT3 activity and reduced SOD2 acetylation, thereby leading to increased SOD2 activity, which could be reversed by treatment with the SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) in vitro and in vivo.	Caffeine	18-26	superoxide dismutase 2	Homo sapiens	110-114
33015038-9	2020	More importantly, caffeine enhanced SIRT3 activity and reduced SOD2 acetylation, thereby leading to increased SOD2 activity, which could be reversed by treatment with the SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) in vitro and in vivo.	Caffeine	18-26	sirtuin 3	Homo sapiens	171-176
32621279-8	2020	The association of caffeine consumption plus physical exercise during adolescence increased the levels of SNAP-25, syntaxin, and serotonin in the hippocampus and prefrontal cortex, and striatal dopamine levels in SHRs.	Caffeine	19-27	synaptosome associated protein 25	Rattus norvegicus	106-113
32652892-8	2020	Moreover, caffeine increased adiponectin production by reducing AKT phosphorylation which increased FOXO1 protein levels in 3T3-L1 mature adipocytes and human SHBG transgenic mice.	Caffeine	10-18	adiponectin, C1Q and collagen domain containing	Homo sapiens	29-40
32652892-8	2020	Moreover, caffeine increased adiponectin production by reducing AKT phosphorylation which increased FOXO1 protein levels in 3T3-L1 mature adipocytes and human SHBG transgenic mice.	Caffeine	10-18	AKT serine/threonine kinase 1	Homo sapiens	64-67
32652892-8	2020	Moreover, caffeine increased adiponectin production by reducing AKT phosphorylation which increased FOXO1 protein levels in 3T3-L1 mature adipocytes and human SHBG transgenic mice.	Caffeine	10-18	forkhead box O1	Homo sapiens	100-105
32652892-8	2020	Moreover, caffeine increased adiponectin production by reducing AKT phosphorylation which increased FOXO1 protein levels in 3T3-L1 mature adipocytes and human SHBG transgenic mice.	Caffeine	10-18	sex hormone binding globulin	Homo sapiens	159-163
32652892-9	2020	Finally, caffeine-induced increase in adiponectin in turn upregulated hepatic HNF-4alpha levels in human SHBG transgenic mice.	Caffeine	9-17	adiponectin, C1Q and collagen domain containing	Homo sapiens	38-49
32652892-9	2020	Finally, caffeine-induced increase in adiponectin in turn upregulated hepatic HNF-4alpha levels in human SHBG transgenic mice.	Caffeine	9-17	sex hormone binding globulin	Homo sapiens	105-109
32652892-10	2020	CONCLUSIONS: Our results showed that caffeine upregulates hepatic SHBG expression by increasing adiponectin production through AKT/FOXO1 pathway in the adipose tissue.	Caffeine	37-45	sex hormone binding globulin	Mus musculus	66-70
32652892-10	2020	CONCLUSIONS: Our results showed that caffeine upregulates hepatic SHBG expression by increasing adiponectin production through AKT/FOXO1 pathway in the adipose tissue.	Caffeine	37-45	adiponectin, C1Q and collagen domain containing	Mus musculus	96-107
32652892-10	2020	CONCLUSIONS: Our results showed that caffeine upregulates hepatic SHBG expression by increasing adiponectin production through AKT/FOXO1 pathway in the adipose tissue.	Caffeine	37-45	thymoma viral proto-oncogene 1	Mus musculus	127-130
32652892-10	2020	CONCLUSIONS: Our results showed that caffeine upregulates hepatic SHBG expression by increasing adiponectin production through AKT/FOXO1 pathway in the adipose tissue.	Caffeine	37-45	forkhead box O1	Mus musculus	131-136
32823594-0	2020	Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players.	Caffeine	69-77	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	11-17
32663519-0	2020	Articular damages in multi-generational female offspring due to prenatal caffeine exposure correlates with H3K9 deacetylation of TGFbeta signaling pathway.	Caffeine	73-81	transforming growth factor alpha	Rattus norvegicus	129-136
32823594-0	2020	Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players.	Caffeine	69-77	adenosine A2a receptor	Homo sapiens	22-29
32823594-2	2020	The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C  > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T  > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players.	Caffeine	163-171	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
32823594-2	2020	The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C  > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T  > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players.	Caffeine	297-305	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
32823594-2	2020	The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C  > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T  > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players.	Caffeine	297-305	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
32823594-8	2020	There was only a genotype x treatment interaction for the ball throwing from 7 m (p = 0.037) indicating that the ergogenic effect of caffeine on this test was higher in CYP1A2 AA homozygotes than in C-allele carriers.	Caffeine	133-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	169-175
32770138-9	2020	Moreover, Caffeine and SCH 58621 were ergogenic, that is, they increased VO2max, running power, and critical power, showing that A2AR antagonism is ergogenic.	Caffeine	10-18	adenosine A2a receptor	Mus musculus	129-133
32823708-4	2020	The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway.	Caffeine	45-53	protein kinase C	Saccharomyces cerevisiae S288C	216-220
32823708-4	2020	The review also focuses on the importance of caffeine-related yeast phenotypes used to resolve molecular mechanisms involved in cell signaling through conserved pathways, such as target of rapamycin (TOR) signaling, Pkc1-Mpk1 mitogen activated protein kinase (MAPK) cascade, or Ras/cAMP protein kinase A (PKA) pathway.	Caffeine	45-53	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	221-225
32770138-10	2020	Furthermore, the ergogenic effects of caffeine were abrogated in global and forebrain A2AR KO mice, showing that the antagonism of A2AR in forebrain neurons is responsible for the ergogenic action of caffeine.	Caffeine	38-46	adenosine A2a receptor	Mus musculus	86-90
32770138-10	2020	Furthermore, the ergogenic effects of caffeine were abrogated in global and forebrain A2AR KO mice, showing that the antagonism of A2AR in forebrain neurons is responsible for the ergogenic action of caffeine.	Caffeine	38-46	adenosine A2a receptor	Mus musculus	131-135
32770138-10	2020	Furthermore, the ergogenic effects of caffeine were abrogated in global and forebrain A2AR KO mice, showing that the antagonism of A2AR in forebrain neurons is responsible for the ergogenic action of caffeine.	Caffeine	200-208	adenosine A2a receptor	Mus musculus	131-135
32770138-11	2020	Furthermore, caffeine modified the exercising metabolism in an A2AR-dependent manner, and A2AR was paramount for exercise thermoregulation.	Caffeine	13-21	adenosine A2a receptor	Mus musculus	63-67
32753637-8	2020	L-Theanine-caffeine combination improved total cognition composite (p = 0.041), d-prime in the Go/NoGo task (p = 0.033) and showed a trend of improvement of inhibitory control (p = 0.080).	Caffeine	11-19	reticulon 4	Homo sapiens	98-102
32663189-9	2020	Unlike the gain-of-function mechanism observed in RYR2-mediated CPVT, the homozygous multi-exon duplication precipitates a dramatic reduction in RYR2 transcription and RyR2 protein translation, a loss-of-function in calcium handling, and a calcium-induced calcium release apparatus that is insensitive to catecholamines and caffeine.	Caffeine	324-332	ryanodine receptor 2	Homo sapiens	145-149
32171942-5	2020	Results from the continuous flow runs showed that the breakthrough curve for compounds caffeine, CBZ, DEET and PFOA follow second order Thomas model with adsorption capacities of 396 mug g-1, 392 mug g-1, 1160 mug g-1 and 32 mug g-1 biochar, respectively.	Caffeine	87-95	proline rich protein BstNI subfamily 3	Homo sapiens	214-224
32756464-7	2020	Statistical regression analysis showed that caffeine intake was a negative predictor of C-reactive protein (CRP) (p = 0.001).	Caffeine	44-52	C-reactive protein	Homo sapiens	88-106
32756464-7	2020	Statistical regression analysis showed that caffeine intake was a negative predictor of C-reactive protein (CRP) (p = 0.001).	Caffeine	44-52	C-reactive protein	Homo sapiens	108-111
32619083-8	2020	Further evidences from both in vivo and in vitro mechanistic experiments demonstrated that caffeine treatment significantly suppressed microglia activation via the A2AR/MEK/ERK/NF-kappaB signaling pathway.	Caffeine	91-99	adenosine A2a receptor	Mus musculus	164-168
32619083-8	2020	Further evidences from both in vivo and in vitro mechanistic experiments demonstrated that caffeine treatment significantly suppressed microglia activation via the A2AR/MEK/ERK/NF-kappaB signaling pathway.	Caffeine	91-99	midkine	Mus musculus	169-172
32619083-8	2020	Further evidences from both in vivo and in vitro mechanistic experiments demonstrated that caffeine treatment significantly suppressed microglia activation via the A2AR/MEK/ERK/NF-kappaB signaling pathway.	Caffeine	91-99	mitogen-activated protein kinase 1	Mus musculus	173-176
32619083-8	2020	Further evidences from both in vivo and in vitro mechanistic experiments demonstrated that caffeine treatment significantly suppressed microglia activation via the A2AR/MEK/ERK/NF-kappaB signaling pathway.	Caffeine	91-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	177-186
32413367-0	2020	A regulatory pathway linking caffeine action, mood and the diurnal clock.	Caffeine	29-37	circadian locomotor output cycles kaput	Mus musculus	67-72
32413367-5	2020	Molecular approaches, transgenic mouse models, pharmacological intervention and behavioral analysis were combined to uncover a regulatory pathway, which connects caffeine action with diurnal signaling via the key dopaminergic protein DARPP-32 and alters mood-related phenotypes in mice, which are often assessed in the context of antidepressant action.	Caffeine	162-170	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	234-242
32413367-7	2020	T75A-DARPP-32 mutant mice show reduced caffeine effects on CLOCK:BMAL1 and lack caffeine-induced effects on mood.	Caffeine	39-47	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	5-13
32413367-7	2020	T75A-DARPP-32 mutant mice show reduced caffeine effects on CLOCK:BMAL1 and lack caffeine-induced effects on mood.	Caffeine	39-47	circadian locomotor output cycles kaput	Mus musculus	59-70
32413367-7	2020	T75A-DARPP-32 mutant mice show reduced caffeine effects on CLOCK:BMAL1 and lack caffeine-induced effects on mood.	Caffeine	80-88	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	5-13
32289327-1	2020	Epidemiological evidence suggests that chronic consumption of caffeine, a non-selective antagonist of adenosine A2AR receptors (A2AR), can be neuroprotective in a number of age-related neurodegenerative disorders including Alzheimer"s disease.	Caffeine	62-70	adenosine A2a receptor	Homo sapiens	112-116
32801978-6	2020	Results: Higher percentage methylation of ESR1 was associated with increased sleep problems, mediated by VMS, even after controlling for age, menopausal status, body mass index, estradiol levels, depressive symptoms, and caffeine consumption.	Caffeine	221-229	estrogen receptor 1	Homo sapiens	42-46
32831996-11	2020	Moreover, treatment with caffeine under hyperoxia modulated the transcription of the adenosine receptor (Adora)1.	Caffeine	25-33	adenosine A1 receptor	Rattus norvegicus	85-112
32831996-12	2020	Caffeine induced pulmonary chemokine and cytokine transcription followed by immune cell infiltration of alveolar macrophages as well as increased adenosine receptor (Adora1, 2a, and 2b) expression.	Caffeine	0-8	adenosine A1 receptor	Rattus norvegicus	146-165
32831996-12	2020	Caffeine induced pulmonary chemokine and cytokine transcription followed by immune cell infiltration of alveolar macrophages as well as increased adenosine receptor (Adora1, 2a, and 2b) expression.	Caffeine	0-8	adenosine A1 receptor	Rattus norvegicus	166-184
32713175-0	2020	Recurrent ADCY5 Mutation in Mosaic Form with Nocturnal Paroxysmal Dyskinesias and Video Electroencephalography Documentation of Dramatic Response to Caffeine Treatment.	Caffeine	149-157	adenylate cyclase 5	Homo sapiens	10-15
32079912-5	2020	RESULTS: Significant interaction between HIIT and CAF was found for OGTT glucose and OGTT insulin levels (P = 0.001 and P = 0.049 respectively).	Caffeine	50-53	insulin	Homo sapiens	90-97
32367472-0	2020	Acute Regulation of the Arousal-Enhancing Drugs Caffeine and Modafinil on Class IIa HDACs In Vivo and In Vitro: Focus on HDAC7.	Caffeine	48-56	ATPase, class II, type 9A	Mus musculus	80-83
32367472-0	2020	Acute Regulation of the Arousal-Enhancing Drugs Caffeine and Modafinil on Class IIa HDACs In Vivo and In Vitro: Focus on HDAC7.	Caffeine	48-56	histone deacetylase 7	Mus musculus	121-126
32367472-13	2020	In vitro studies revealed that modafinil increased hdac4, hdac5, and hdac7 mRNA levels in N2a, while caffeine only increased hdac5 at a higher dose.	Caffeine	101-109	histone deacetylase 5	Mus musculus	125-130
32367472-14	2020	These findings support the notion that modafinil and caffeine exert distinct regulation of class IIa HDAC family members and that these transcriptional and translational consequences are region-specific.	Caffeine	53-61	ATPase, class II, type 9A	Mus musculus	97-100
32222015-8	2020	RESULTS: There was a significant effect of caffeine consumption (P < 0.001, eta2  = 0.50), showing that the ingestion of caffeine before exercise counteracted the IOP-lowering response to low-intensity endurance exercise.	Caffeine	43-51	DNA polymerase iota	Homo sapiens	76-80
32237230-3	2020	Herein, we describe two structurally related and readily available artificial receptors: 1) a macrocyclic receptor, which binds caffeine with the unprecedented affinity of 9.3 muM, though with poor selectivity; and 2) a tweezers-like structure, showing an affinity of 26 muM and a 4.5-fold and 6-fold selectivity toward theophylline and theobromine, respectively.	Caffeine	128-136	latexin	Homo sapiens	176-179
32237230-3	2020	Herein, we describe two structurally related and readily available artificial receptors: 1) a macrocyclic receptor, which binds caffeine with the unprecedented affinity of 9.3 muM, though with poor selectivity; and 2) a tweezers-like structure, showing an affinity of 26 muM and a 4.5-fold and 6-fold selectivity toward theophylline and theobromine, respectively.	Caffeine	128-136	latexin	Homo sapiens	271-274
32222015-8	2020	RESULTS: There was a significant effect of caffeine consumption (P < 0.001, eta2  = 0.50), showing that the ingestion of caffeine before exercise counteracted the IOP-lowering response to low-intensity endurance exercise.	Caffeine	121-129	DNA polymerase iota	Homo sapiens	76-80
32356023-0	2020	The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults.	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	65-71
32356023-6	2020	The effect of caffeine was greater for CYP1A2 "fast" vs. "slow" metabolisers for reaction time during exercise (- 18 +- 9 vs. - 1.0 +- 11 ms); fastest 10% reaction time at rest (- 18 +- 11 vs. - 3 +- 15 ms) and lapses at rest (- 3.8 +- 2.7 vs. + 0.4 +- 0.9) (P < 0.05).	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
32356023-9	2020	CONCLUSION: Caffeine enhanced CYP1A2 "fast" metabolisers" cognitive performance more than "slow" metabolisers.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-36
31578132-9	2020	The CAF trial resulted in significantly higher MIP (154.7 +- 35.8 vs. 146.6 +- 37.6 cmH20; p = 0.02) and PP (165.8 +- 36.8 vs. 158.3 cmH20; p = 0.01) compared to the PL condition.	Caffeine	4-7	nexilin F-actin binding protein	Homo sapiens	84-89
32569126-12	2020	Our results show that 4-mg kg caffeine improves performance in individuals with the HTR2A CC genotype but only in those who are also CYP1A2 AA fast metabolizers.	Caffeine	30-38	5-hydroxytryptamine receptor 2A	Homo sapiens	84-89
31578132-9	2020	The CAF trial resulted in significantly higher MIP (154.7 +- 35.8 vs. 146.6 +- 37.6 cmH20; p = 0.02) and PP (165.8 +- 36.8 vs. 158.3 cmH20; p = 0.01) compared to the PL condition.	Caffeine	4-7	nexilin F-actin binding protein	Homo sapiens	133-138
32569126-0	2020	Effect of Caffeine on Endurance Performance in Athletes May Depend on HTR2A and CYP1A2 Genotypes.	Caffeine	10-18	5-hydroxytryptamine receptor 2A	Homo sapiens	70-75
32569126-0	2020	Effect of Caffeine on Endurance Performance in Athletes May Depend on HTR2A and CYP1A2 Genotypes.	Caffeine	10-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
32615857-6	2020	The CC genotype of ADORA2A rs2236624 SNP in patients with lower caffeine intake treated with MTX is significantly protective.	Caffeine	64-72	adenosine A2a receptor	Homo sapiens	19-26
32437139-4	2020	We identified two human bitter taste receptors, TAS2R43 and TAS2R46, that responded to the bitter substance mozambioside with much higher sensitivity than to caffeine.	Caffeine	158-166	taste 2 receptor member 43	Homo sapiens	48-55
32437139-4	2020	We identified two human bitter taste receptors, TAS2R43 and TAS2R46, that responded to the bitter substance mozambioside with much higher sensitivity than to caffeine.	Caffeine	158-166	taste 2 receptor member 46	Homo sapiens	60-67
32569126-12	2020	Our results show that 4-mg kg caffeine improves performance in individuals with the HTR2A CC genotype but only in those who are also CYP1A2 AA fast metabolizers.	Caffeine	30-38	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	133-139
32569126-2	2020	Effect of caffeine on endurance performance in athletes may depend on HTR2A and CYP1A2 genotypes.	Caffeine	10-18	5-hydroxytryptamine receptor 2A	Homo sapiens	70-75
32569126-2	2020	Effect of caffeine on endurance performance in athletes may depend on HTR2A and CYP1A2 genotypes.	Caffeine	10-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
32612520-1	2020	Immunolabeling for adenosine A1 receptors (A1Rs) is high in hippocampal area CA2 in adult rats, and the potentiating effects of caffeine or other A1R-selective antagonists on synaptic responses are particularly robust at Schaffer collateral synapses in CA2.	Caffeine	128-136	carbonic anhydrase 2	Rattus norvegicus	253-256
32569126-3	2020	J Strength Cond Res XX(X): 000-000, 2020-This investigation determined whether variation in the HTR2A (serotonin receptor) gene modifies the ergogenic effects of caffeine on endurance and further modifies performance by the CYP1A2 genotype.	Caffeine	162-170	5-hydroxytryptamine receptor 2A	Homo sapiens	96-101
32569126-8	2020	A significant caffeine-HTR2A interaction (p = 0.003) was observed; however, after adjustment for placebo trials, the interaction was no longer significant (p = 0.37).	Caffeine	14-22	5-hydroxytryptamine receptor 2A	Homo sapiens	23-28
32549382-0	2020	Caffeine and Caffeine Metabolites in Relation to Insulin Resistance and Beta Cell Function in U.S.	Caffeine	0-8	insulin	Homo sapiens	49-56
32549382-0	2020	Caffeine and Caffeine Metabolites in Relation to Insulin Resistance and Beta Cell Function in U.S.	Caffeine	13-21	insulin	Homo sapiens	49-56
32549382-2	2020	The relationship between caffeine and insulin resistance (IR) has been assessed only in terms of caffeine intake, and the association between caffeine and beta cell function (BCF) remains unclear.	Caffeine	25-33	insulin	Homo sapiens	38-45
32513156-0	2020	Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	0-8	NLR family, pyrin domain containing 3	Mus musculus	73-78
32513156-0	2020	Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
32513156-12	2020	RESULTS: We found that the caffeine concentration in plasma at present dose significantly decreased the expression of A2AR protein in mice lung.	Caffeine	27-35	adenosine A2a receptor	Mus musculus	118-122
32513156-15	2020	The expression of NLRP3 inflammasome protein and NF-kappaB pathway were significantly inhibited by caffeine treatment.	Caffeine	99-107	NLR family, pyrin domain containing 3	Mus musculus	18-23
32513156-15	2020	The expression of NLRP3 inflammasome protein and NF-kappaB pathway were significantly inhibited by caffeine treatment.	Caffeine	99-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
32513156-16	2020	CONCLUSION: Caffeine treatment can protect hyperoxia-induced mice lung from oxidative injury by inhibiting NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	12-20	NLR family, pyrin domain containing 3	Mus musculus	107-112
32513156-16	2020	CONCLUSION: Caffeine treatment can protect hyperoxia-induced mice lung from oxidative injury by inhibiting NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	12-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
32566904-1	2020	Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli.	Caffeine	20-28	reticulon 4	Homo sapiens	104-108
32199975-0	2020	GR/HDAC2/TGFbetaR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.	Caffeine	51-59	glutathione-disulfide reductase	Rattus norvegicus	0-2
32199975-0	2020	GR/HDAC2/TGFbetaR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.	Caffeine	51-59	histone deacetylase 2	Rattus norvegicus	3-8
32145313-1	2020	An efficient, microwave-assisted, oxidant-interceded, transition-metal-free, cross-dehydrogenative Csp2-Csp3 coupling of C8-Caffeine 2/Theobromine 3/theophylline 4 with substituted aliphatic alcohols 11a-lvia CH bond activation for the preparation of series of substituted C8-(hydroxymethyl) Caffeine 12a-l/theobromine 13a-c/theophylline 14a-b has been developed using microwave irradiation upto 98% yield.	Caffeine	124-132	regulator of calcineurin 2	Homo sapiens	99-103
32566904-1	2020	Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli.	Caffeine	20-28	reticulon 4	Homo sapiens	195-199
32566904-4	2020	Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity.	Caffeine	30-38	reticulon 4	Homo sapiens	118-122
32566904-4	2020	Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity.	Caffeine	30-38	reticulon 4	Homo sapiens	154-158
32476096-0	2020	Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring.	Caffeine	65-73	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	14-20
32476094-10	2020	Emc4p overexpression also protected the wild type and mutant (gcd7-201 gcn2 , GCD7 gcn2 , and GCD7 GCN2 ) strains from H2O2, ethanol, and caffeine stress.	Caffeine	138-146	chaperone EMC4	Saccharomyces cerevisiae S288C	0-5
32476096-5	2020	Consumption of acetaminophen correlated significantly with changes in caffeine metabolism (acetaminophen R2 = 0.637, p = 0.01) due to activation of CYP2E1 alternate pathways.	Caffeine	70-78	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	148-154
31255351-11	2020	Four of the ten were associated [glycine (inversely), caffeine, 1,7-dimethyluric acid, C52:3 triacylglycerol, (positively)], with C-reactive protein levels.	Caffeine	54-62	C-reactive protein	Homo sapiens	130-148
32392893-7	2020	Furthermore, effects of RNA interference of vitellogenin (vit) genes, vit-1 to vit-6, in P0 mothers can mimic those by caffeine-ingested mothers.	Caffeine	119-127	F-box protein 11	Homo sapiens	70-75
32386647-0	2020	High-Dose Insulin Euglycemic Therapy in the Treatment of a Massive Caffeine Overdose.	Caffeine	67-75	insulin	Homo sapiens	10-17
32386647-6	2020	Although high-dose insulin is effective in beta-blocker, calcium channel blocker, and tricyclic antidepressant overdose, this is seemingly the first description of its successful use in caffeine toxicity.	Caffeine	186-194	insulin	Homo sapiens	19-26
32219694-4	2020	Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	76-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-17
32219694-4	2020	Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	76-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-55
32471290-6	2020	Here, we were able to prove a positive benefit on affected motor neurons from an additional NAD+ supply as well as an increase in the Nmnat2 level through caffeine treatment in cells in vitro.	Caffeine	155-163	nicotinamide nucleotide adenylyltransferase 2	Mus musculus	134-140
32106030-3	2020	Hence in this study we aimed to investigate the preventive role of antioxidants present in our diet, like caffeine and catechin hydrate which are commonly found in coffee and tea towards methemoglobin (met-Hb) formation.	Caffeine	106-114	hemoglobin subunit gamma 2	Homo sapiens	187-200
32171111-8	2020	The ICE frequencies observed after G2/M abrogation by caffeine are similar to the ones without abrogation, and clearly lower to the ones observed in G2.	Caffeine	54-62	carboxylesterase 2	Homo sapiens	4-7
31610604-5	2020	Metabolisation of caffeine mainly depends on cytochrome P450 1A2.	Caffeine	18-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	45-64
31941844-7	2020	Oil Red-O staining results revealed a decrease in lipid droplets; furthermore, PPARgamma, C/EBPalpha, and C/EBPbeta protein expression levels were inhibited upon treatment with caffeine during adipocyte differentiation.	Caffeine	177-185	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
31974940-6	2020	A single dose of caffeine directly after HI resulted in a reduction of the lesion in the grey and white matter, judged by immunostaining of MAP2 and MBP, respectively, compared to PBS-treated controls.	Caffeine	17-25	microtubule-associated protein 2	Mus musculus	140-144
32411098-2	2020	Previously, we described that chronic caffeine intake prevents and reverses insulin resistance induced by hypercaloric diets and aging, in rats.	Caffeine	38-46	insulin	Homo sapiens	76-83
32411098-4	2020	Here, we investigated the subtypes of adenosine receptors involved on the effects of chronic caffeine intake on insulin sensitivity and the mechanisms and sex differences behind this effect.	Caffeine	93-101	insulin	Homo sapiens	112-119
31941844-7	2020	Oil Red-O staining results revealed a decrease in lipid droplets; furthermore, PPARgamma, C/EBPalpha, and C/EBPbeta protein expression levels were inhibited upon treatment with caffeine during adipocyte differentiation.	Caffeine	177-185	CCAAT enhancer binding protein alpha	Homo sapiens	90-100
32071850-2	2020	The elimination of caffeine from the body follows first-order kinetics and principally involves catabolism by hepatic CYP1A2, with a half-life usually between three and 7 h. It is known that this process is affected by age and smoking tobacco.	Caffeine	19-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124
31941844-7	2020	Oil Red-O staining results revealed a decrease in lipid droplets; furthermore, PPARgamma, C/EBPalpha, and C/EBPbeta protein expression levels were inhibited upon treatment with caffeine during adipocyte differentiation.	Caffeine	177-185	CCAAT enhancer binding protein beta	Homo sapiens	106-115
31918058-5	2020	Without affecting essential determinants of the Ca2+ feedthrough mechanism, we found that luminal Eu3+ competitively antagonized the activation effect of luminal Ca2+ on RYR2 responsiveness to cytosolic caffeine, and no appreciable effect was observed for luminal Ba2+ (mimicking the absence of luminal Ca2+).	Caffeine	203-211	ryanodine receptor 2	Homo sapiens	170-174
32499888-2	2020	In addition to the regulation of the RyR channel by exogenous substances (caffeine, ryanodine), ions environmental situations (oxidative state), other components, such as some endogenous proteins present in the sarcoplasm and/or in muscle membranes that are able to determine changes in Ca2+ channel activity.	Caffeine	74-82	ryanodine receptor 1	Homo sapiens	37-40
31834119-0	2020	Prenatal caffeine exposure induces down-regulation of the protein kinase A/ryanodine receptor/large-conductance Ca2+-activated K+ pathway in the cerebral arteries of old offspring rats.	Caffeine	9-17	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	58-74
32295624-1	2020	BACKGROUND: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine.	Caffeine	120-128	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
32252408-13	2020	The concentrations were variable and ranged from ng L-1 in some compounds like diclofenac or carbamazepine to microg L-1 in common pharmaceutical compounds such as caffeine, naproxen or ibuprofen.	Caffeine	164-172	L1 cell adhesion molecule	Homo sapiens	117-120
32062581-3	2020	Caffeine exposure also induced a strong DDR along with subsequent activation of wildtype p53 protein.	Caffeine	0-8	tumor protein p53	Homo sapiens	89-92
32062581-4	2020	An unexpected observation was the caffeine-induced depletion of Rad51 (and Brca2) proteins.	Caffeine	34-42	RAD51 recombinase	Homo sapiens	64-69
32062581-4	2020	An unexpected observation was the caffeine-induced depletion of Rad51 (and Brca2) proteins.	Caffeine	34-42	BRCA2 DNA repair associated	Homo sapiens	75-80
32062581-10	2020	Thus, prolonged caffeine exposure stalls the cell cycle, induces a p53-mediated apoptotic response and a down-regulation of critical HR proteins, and for reasons discussed, stimulates early steps of HR, but not the formation of complete recombination products.	Caffeine	16-24	tumor protein p53	Homo sapiens	67-70
32092208-4	2020	In a non-fatigued state caffeine decreased the duration of the silent period evoked by TMS.	Caffeine	24-32	PYD and CARD domain containing	Homo sapiens	87-90
31834119-10	2020	The sensitivity of ryanodine receptors to the PKA agonist was blunted in the Caf group, whereas the mRNA expression of ryanodine receptor 2 subunit was reduced.	Caffeine	77-80	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	46-49
31834119-11	2020	Voltage/Ca sensitivity of BKCa was decreased accompanied by reduced mRNA and protein expression of BKCa-beta1 subunits in the Caf group.	Caffeine	126-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	26-30
31834119-11	2020	Voltage/Ca sensitivity of BKCa was decreased accompanied by reduced mRNA and protein expression of BKCa-beta1 subunits in the Caf group.	Caffeine	126-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	99-103
31834119-12	2020	PKA agonist-stimulated inside-out BKCa currents were weaker in the Caf group.	Caffeine	67-70	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-3
31834119-12	2020	PKA agonist-stimulated inside-out BKCa currents were weaker in the Caf group.	Caffeine	67-70	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	34-38
31834119-13	2020	CONCLUSION: Prenatal exposure to Caf-affected isoprenaline/forskolin-mediated vascular functions in aged cerebral arteries, related to dysfunction of the PKA/ryanodine receptors/BKCa signaling pathway.	Caffeine	33-36	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	154-157
31834119-13	2020	CONCLUSION: Prenatal exposure to Caf-affected isoprenaline/forskolin-mediated vascular functions in aged cerebral arteries, related to dysfunction of the PKA/ryanodine receptors/BKCa signaling pathway.	Caffeine	33-36	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	178-182
32071850-11	2020	The mean (standard error) salivary caffeine clearance in the male subjects was 1.51 (0.10) mL min-1 kg-1, while that in the female subjects was 1.60 (0.07) mL min-1 kg-1 (p = 0.495).	Caffeine	35-43	CD59 molecule (CD59 blood group)	Homo sapiens	94-104
32050085-6	2020	Without any significant impact on the vitality or MScs" marker, Caffeine at this concentration could induce lower levels of IFN-gamma, IL-6, and IL-1beta and a higher level of IDO, TGF-beta, and IL-10 compared to other groups.	Caffeine	64-72	interferon gamma	Rattus norvegicus	124-133
32050085-6	2020	Without any significant impact on the vitality or MScs" marker, Caffeine at this concentration could induce lower levels of IFN-gamma, IL-6, and IL-1beta and a higher level of IDO, TGF-beta, and IL-10 compared to other groups.	Caffeine	64-72	interleukin 6	Rattus norvegicus	135-139
32050085-6	2020	Without any significant impact on the vitality or MScs" marker, Caffeine at this concentration could induce lower levels of IFN-gamma, IL-6, and IL-1beta and a higher level of IDO, TGF-beta, and IL-10 compared to other groups.	Caffeine	64-72	interleukin 1 alpha	Rattus norvegicus	145-153
32050085-6	2020	Without any significant impact on the vitality or MScs" marker, Caffeine at this concentration could induce lower levels of IFN-gamma, IL-6, and IL-1beta and a higher level of IDO, TGF-beta, and IL-10 compared to other groups.	Caffeine	64-72	interleukin 10	Rattus norvegicus	195-200
32050085-9	2020	Furthermore, Caffeine pulsed MSCs caused a significant reduction in the serum levels C-reactive protein, Nitric oxide, Myeloperoxidase, TNF-alpha and conversely led a significant increase in the levels of IL-10 more prominent than the similar findings brought about by MSCs alone.	Caffeine	13-21	C-reactive protein	Rattus norvegicus	85-103
32050085-9	2020	Furthermore, Caffeine pulsed MSCs caused a significant reduction in the serum levels C-reactive protein, Nitric oxide, Myeloperoxidase, TNF-alpha and conversely led a significant increase in the levels of IL-10 more prominent than the similar findings brought about by MSCs alone.	Caffeine	13-21	myeloperoxidase	Rattus norvegicus	119-134
32050085-9	2020	Furthermore, Caffeine pulsed MSCs caused a significant reduction in the serum levels C-reactive protein, Nitric oxide, Myeloperoxidase, TNF-alpha and conversely led a significant increase in the levels of IL-10 more prominent than the similar findings brought about by MSCs alone.	Caffeine	13-21	tumor necrosis factor	Rattus norvegicus	136-145
32050085-9	2020	Furthermore, Caffeine pulsed MSCs caused a significant reduction in the serum levels C-reactive protein, Nitric oxide, Myeloperoxidase, TNF-alpha and conversely led a significant increase in the levels of IL-10 more prominent than the similar findings brought about by MSCs alone.	Caffeine	13-21	interleukin 10	Rattus norvegicus	205-210
31756336-10	2020	By showing that caffeine and A2AR may act at neuronal level rescuing ADHD neurons outgrowth, our findings strengthen the potential of caffeine and A2AR receptors as an adjuvant for ADHD treatment.	Caffeine	16-24	adenosine A2a receptor	Rattus norvegicus	147-151
31756336-10	2020	By showing that caffeine and A2AR may act at neuronal level rescuing ADHD neurons outgrowth, our findings strengthen the potential of caffeine and A2AR receptors as an adjuvant for ADHD treatment.	Caffeine	134-142	adenosine A2a receptor	Rattus norvegicus	29-33
31705690-7	2020	Both caffeine and RmTBI increased spine density in the Cg3 (medial prefrontal cortex (mPFC)), AID (orbitofrontal cortex (OFC)), and nucleus accumbens (NAc), which is proposed to reflect an impairment in the normal pruning processes.	Caffeine	5-13	activation-induced cytidine deaminase	Rattus norvegicus	94-97
31955628-0	2020	Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	59-63
32168870-3	2020	It has been suggested that ADORA2A gene polymorphisms may be responsible for the inter-individual variations in the effects of caffeine on exercise performance.	Caffeine	127-135	adenosine A2a receptor	Homo sapiens	27-34
32168870-4	2020	In the only study that explored the influence of variation in ADORA2A-in this case, a common polymorphism (rs5751876)-on the ergogenic effects of caffeine on exercise performance, C allele carriers were identified as "non-responders" to caffeine.	Caffeine	146-154	adenosine A2a receptor	Homo sapiens	62-69
32168870-9	2020	In conclusion, ADORA2A (rs5751876) C allele carriers exhibited ergogenic responses to caffeine ingestion, with the magnitude of improvements similar to what was previously reported in the literature among samples that were not genotype-specific.	Caffeine	86-94	adenosine A2a receptor	Homo sapiens	15-22
31707092-6	2020	Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	19-22
31707092-6	2020	Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	104-108
31707092-6	2020	Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex.	Caffeine	0-8	synaptosomal-associated protein 25	Mus musculus	139-146
31707092-6	2020	Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex.	Caffeine	85-93	adenosine A2a receptor	Mus musculus	104-108
31707092-6	2020	Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex.	Caffeine	85-93	synaptosomal-associated protein 25	Mus musculus	139-146
31608602-11	2020	CYP1A2 activity was assessed 2 hours after the ingestion of a drink containing caffeine through measurement of the metabolic ratio of paraxanthine (17X) over caffeine (137X) by LC-MS/MS or LC-UV.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
31608602-11	2020	CYP1A2 activity was assessed 2 hours after the ingestion of a drink containing caffeine through measurement of the metabolic ratio of paraxanthine (17X) over caffeine (137X) by LC-MS/MS or LC-UV.	Caffeine	158-166	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
32146599-11	2020	This nanoprobe exhibits low SERS interference for structural analogues theobromine (THB) and caffeine (CAF).	Caffeine	93-101	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	28-32
32146599-11	2020	This nanoprobe exhibits low SERS interference for structural analogues theobromine (THB) and caffeine (CAF).	Caffeine	103-106	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	28-32
31456413-5	2020	Inhibition of mitochondrial Ca2+ uptake (MCU) with Ru360 attenuated agonist-induced [ROS]m. Ru360 produced a similar inhibitory effect on hypoxia-induced [ROS]m. Rieske iron-sulfur protein (RISP) gene knockdown inhibited Ca2+- and caffeine-induced [ROS]m. Inhibition of RyR2 by tetracaine or RyR2 gene knockout suppressed hypoxia-induced [ROS]m as well.	Caffeine	231-239	mitochondrial calcium uniporter	Homo sapiens	41-44
31456413-5	2020	Inhibition of mitochondrial Ca2+ uptake (MCU) with Ru360 attenuated agonist-induced [ROS]m. Ru360 produced a similar inhibitory effect on hypoxia-induced [ROS]m. Rieske iron-sulfur protein (RISP) gene knockdown inhibited Ca2+- and caffeine-induced [ROS]m. Inhibition of RyR2 by tetracaine or RyR2 gene knockout suppressed hypoxia-induced [ROS]m as well.	Caffeine	231-239	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	162-188
31917645-8	2020	Also, in order to determine the accuracy of the developed method, selected coffee samples were spiked with 25 and 50 microg mL-1 caffeine.	Caffeine	129-137	L1 cell adhesion molecule	Mus musculus	124-128
31955628-0	2020	Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells.	Caffeine	0-8	BP1	Homo sapiens	74-77
31955628-4	2020	Evidence also suggested that caffeine inhibits the mTOR pathway.	Caffeine	29-37	mechanistic target of rapamycin kinase	Homo sapiens	51-55
31955628-8	2020	The phosphorylation of mTOR, p70S6K, and 4E-BP1 markedly decreased in cells exposed to caffeine after ethanol pretreatment, associated with a decrease of the mitochondrial membrane potential (DeltaPsim).	Caffeine	87-95	mechanistic target of rapamycin kinase	Homo sapiens	23-27
31955628-8	2020	The phosphorylation of mTOR, p70S6K, and 4E-BP1 markedly decreased in cells exposed to caffeine after ethanol pretreatment, associated with a decrease of the mitochondrial membrane potential (DeltaPsim).	Caffeine	87-95	ribosomal protein S6 kinase B1	Homo sapiens	29-35
31955628-8	2020	The phosphorylation of mTOR, p70S6K, and 4E-BP1 markedly decreased in cells exposed to caffeine after ethanol pretreatment, associated with a decrease of the mitochondrial membrane potential (DeltaPsim).	Caffeine	87-95	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	41-47
31955628-9	2020	These findings suggested that caffeine treatment after neuronal cells were exposed to ethanol resulted in marked cell damages, mediated through enhanced inhibition of mTOR/p70S6K/4E-BP1 signaling leading to impaired DeltaPsim and, eventually, apoptotic cell death.	Caffeine	30-38	mechanistic target of rapamycin kinase	Homo sapiens	167-171
31955628-9	2020	These findings suggested that caffeine treatment after neuronal cells were exposed to ethanol resulted in marked cell damages, mediated through enhanced inhibition of mTOR/p70S6K/4E-BP1 signaling leading to impaired DeltaPsim and, eventually, apoptotic cell death.	Caffeine	30-38	BP1	Homo sapiens	182-185
32104547-4	2020	Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor beta, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis.	Caffeine	33-41	AKT serine/threonine kinase 1	Homo sapiens	146-149
32050158-5	2020	Therefore, the aim of this study was to develop, validate and optimize a simplified assay for the probe drugs caffeine (metabolized by CYP1A2), omeprazole (CYP2C19), losartan (CYP2C9), dextromethorphan (CYP2D6), midazolam (CYP3A4) and their respective enzyme-specific metabolites in small volumes (100 muL) of human plasma, that addresses the issues noted.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-141
32050158-5	2020	Therefore, the aim of this study was to develop, validate and optimize a simplified assay for the probe drugs caffeine (metabolized by CYP1A2), omeprazole (CYP2C19), losartan (CYP2C9), dextromethorphan (CYP2D6), midazolam (CYP3A4) and their respective enzyme-specific metabolites in small volumes (100 muL) of human plasma, that addresses the issues noted.	Caffeine	110-118	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	176-182
32050158-5	2020	Therefore, the aim of this study was to develop, validate and optimize a simplified assay for the probe drugs caffeine (metabolized by CYP1A2), omeprazole (CYP2C19), losartan (CYP2C9), dextromethorphan (CYP2D6), midazolam (CYP3A4) and their respective enzyme-specific metabolites in small volumes (100 muL) of human plasma, that addresses the issues noted.	Caffeine	110-118	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	203-209
32050158-5	2020	Therefore, the aim of this study was to develop, validate and optimize a simplified assay for the probe drugs caffeine (metabolized by CYP1A2), omeprazole (CYP2C19), losartan (CYP2C9), dextromethorphan (CYP2D6), midazolam (CYP3A4) and their respective enzyme-specific metabolites in small volumes (100 muL) of human plasma, that addresses the issues noted.	Caffeine	110-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	223-229
32078115-4	2020	We observed that 48-h exposure (during synaptogenesis) to a moderate dose of caffeine (30 mg/kg of egg) activated pro-survival signaling pathways, including ERK, CREB, and Akt phosphorylation, alongside BDNF production, and reduced retinal cell death promoted by oxygen glucose deprivation in the chick retina.	Caffeine	77-85	brain derived neurotrophic factor	Gallus gallus	203-207
32078115-5	2020	Blockade of TrkB receptors and inhibition of CREB prevented caffeine protection effect.	Caffeine	60-68	neurotrophic receptor tyrosine kinase 2	Homo sapiens	12-16
32078115-8	2020	Caffeine decreased the levels of the chloride co-transporter KCC2 and delayed the developmental shift on GABAA receptor response from depolarizing to hyperpolarizing.	Caffeine	0-8	solute carrier family 12 member 5	Homo sapiens	61-65
32078115-11	2020	In summary, an in vivo caffeine exposure could increase the resistance of the retina to ischemia-induced cell death, by triggering survival pathways involving CREB phosphorylation and BDNF production/TrkB activation.	Caffeine	23-31	brain derived neurotrophic factor	Gallus gallus	184-188
32078115-11	2020	In summary, an in vivo caffeine exposure could increase the resistance of the retina to ischemia-induced cell death, by triggering survival pathways involving CREB phosphorylation and BDNF production/TrkB activation.	Caffeine	23-31	neurotrophic receptor tyrosine kinase 2	Homo sapiens	200-204
32112553-4	2020	Our results indicated that Ca2+ spark activity and STOCs were significantly reduced in the DO detrusor myocytes compared to unafflicted control cells, and both of these had levels that were remarkably increased by applications of caffeine (10 muM), a RyR agonist, in DO myocytes.	Caffeine	230-238	ryanodine receptor 2	Rattus norvegicus	251-254
32121218-1	2020	Methylliberine (Dynamine ; DYM) and theacrine (Teacrine ; TCR) are purine alkaloids purported to have similar neuro-energetic effects as caffeine.	Caffeine	137-145	dymeclin	Homo sapiens	27-30
32104547-4	2020	Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor beta, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis.	Caffeine	33-41	mechanistic target of rapamycin kinase	Homo sapiens	150-179
32104547-4	2020	Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor beta, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis.	Caffeine	240-248	AKT serine/threonine kinase 1	Homo sapiens	146-149
32104547-4	2020	Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor beta, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis.	Caffeine	240-248	mechanistic target of rapamycin kinase	Homo sapiens	150-179
32042141-0	2020	Ryanodine receptor modulation by caffeine challenge modifies Na+ current properties in intact murine skeletal muscle fibres.	Caffeine	33-41	ryanodine receptor 1, skeletal muscle	Mus musculus	0-18
32042141-7	2020	These effects were abrogated if caffeine was added after establishing the patch seal or with RyR block by 10 muM dantrolene.	Caffeine	32-40	ryanodine receptor 1, skeletal muscle	Mus musculus	93-96
31744669-0	2020	Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.	Caffeine	82-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-64
31744669-2	2020	A sensitive, specific, and fast ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for determination of caffeine (probe of CYP1A2), tolbutamide (probe of CYP2C9), dextromethorphan (probe of CYP2D6), and alprazolam (probe of CYP3A4/5) in human serum.	Caffeine	172-180	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	191-197
31744669-2	2020	A sensitive, specific, and fast ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for determination of caffeine (probe of CYP1A2), tolbutamide (probe of CYP2C9), dextromethorphan (probe of CYP2D6), and alprazolam (probe of CYP3A4/5) in human serum.	Caffeine	172-180	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	222-228
31744669-2	2020	A sensitive, specific, and fast ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for determination of caffeine (probe of CYP1A2), tolbutamide (probe of CYP2C9), dextromethorphan (probe of CYP2D6), and alprazolam (probe of CYP3A4/5) in human serum.	Caffeine	172-180	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	258-264
31744669-2	2020	A sensitive, specific, and fast ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for determination of caffeine (probe of CYP1A2), tolbutamide (probe of CYP2C9), dextromethorphan (probe of CYP2D6), and alprazolam (probe of CYP3A4/5) in human serum.	Caffeine	172-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	292-300
31396885-3	2020	The electrochemical behavior of caffeine on Pt-GR/GCE was studied by differential pulse voltammetry (DPV).	Caffeine	32-40	glycine decarboxylase	Homo sapiens	44-53
31396885-4	2020	The results showed that a sensitive oxidation peak was observed at 1.336 V in 0.01 mol L-1 H2SO4 buffer solution, indicating that the Pt-GR/GCE exhibited a good electrooxidation activity towards caffeine.	Caffeine	195-203	glycine decarboxylase	Homo sapiens	134-143
31845986-8	2020	In the presence of the cell cycle checkpoint inhibitor caffeine, the level of MN formed after irradiation was similar between control and OXR1-depleted cells, demonstrating that OXR1-depletion accelerates MN formation through abrogation of G2/M arrest.	Caffeine	55-63	oxidation resistance 1	Homo sapiens	178-182
31437535-8	2020	Furthermore, when co-expressed with the type 2 ryanodine receptor, caffeine-induced calcium release from TRISK32-L56P-GFP was relatively lower compared to that observed with the wild-type construct.	Caffeine	67-75	ryanodine receptor 2	Homo sapiens	40-65
32047430-3	2019	CYP1A2 and CYP2E1 activity was evaluated from changes in pharmacokinetic parameters of caffeine and chlorzoxazone, respectively.	Caffeine	87-95	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
32047430-3	2019	CYP1A2 and CYP2E1 activity was evaluated from changes in pharmacokinetic parameters of caffeine and chlorzoxazone, respectively.	Caffeine	87-95	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	11-17
32047430-8	2019	The metabolism of caffeine and chlorzoxazone increased under X-ray irradiation as CL levels increased and AUC levels decreased, suggesting that CYP1A2 and CYP2E1 activity is enhanced in rats after X-ray irradiation.	Caffeine	18-26	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	144-150
32047430-8	2019	The metabolism of caffeine and chlorzoxazone increased under X-ray irradiation as CL levels increased and AUC levels decreased, suggesting that CYP1A2 and CYP2E1 activity is enhanced in rats after X-ray irradiation.	Caffeine	18-26	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	155-161
31880932-2	2020	In this study, we elucidated the mechanism underlying the copigmentation of MGR upon complexation with caffeine.	Caffeine	103-111	MGR6	Homo sapiens	76-79
31936548-7	2020	Based on evidence, caffeine is proposed as an effective, safe, and reliable choice to inhibit SSAO activity.	Caffeine	19-27	amine oxidase copper containing 2	Homo sapiens	94-98
31629349-1	2020	Caffeine is a well-established ergogenic aid, with its performance-enhancing effects demonstrated across a wide variety of exercise modalities.	Caffeine	0-8	activation induced cytidine deaminase	Homo sapiens	41-44
32990013-0	2020	The dosage-dependent prenatal caffeine exposure adversely affects levels of integrin alphaVbeta3 and MMP-9 in a rat model of embryo implantation.	Caffeine	30-38	matrix metallopeptidase 9	Rattus norvegicus	101-106
32990013-9	2020	CONCLUSION:  It has been shown that the levels of integrin alphaVbeta3 and MMP-9 were decreased by prenatal caffeine consumption in rats, which resulted in a decrease in embryo implantation in a dose-dependent manner, especially in the high-dose group (Fig.	Caffeine	108-116	matrix metallopeptidase 9	Rattus norvegicus	75-80
31765739-0	2020	Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure.	Caffeine	149-157	solute carrier family 2 member 1	Rattus norvegicus	23-28
32054357-7	2020	Annexin-V analysis by flow cytometry revealed 2- to 6-fold increases in annexin-V-positive cells in Dox-treated MCF7 and HCT116 cells by Cur (15 microM), Caff (10 mM), and TQ (50 microM; P &lt; .001).	Caffeine	154-158	annexin A5	Homo sapiens	0-9
32054357-7	2020	Annexin-V analysis by flow cytometry revealed 2- to 6-fold increases in annexin-V-positive cells in Dox-treated MCF7 and HCT116 cells by Cur (15 microM), Caff (10 mM), and TQ (50 microM; P &lt; .001).	Caffeine	154-158	annexin A5	Homo sapiens	72-81
29796873-10	2020	We found that atorvastatin and caffeine in combination downregulated phospho-Akt, phospho-Erk1/2, anti-apoptotic Bcl-2 and Survivin protein levels.	Caffeine	31-39	AKT serine/threonine kinase 1	Homo sapiens	77-80
29796873-10	2020	We found that atorvastatin and caffeine in combination downregulated phospho-Akt, phospho-Erk1/2, anti-apoptotic Bcl-2 and Survivin protein levels.	Caffeine	31-39	BCL2 apoptosis regulator	Homo sapiens	113-118
31960608-10	2020	The addition of autophagy inhibitors 3-methyladenine (10 mM) or bafilomycin A1 (10 muM) reduced caffeine-dependent lipid utilization by approximately 30%.	Caffeine	96-104	latexin	Homo sapiens	83-86
31765739-8	2020	In vitro, the expression levels of IGF1 and GLUT1 were inhibited by corticosterone but remained unchanged under caffeine treatment.	Caffeine	112-120	insulin-like growth factor 1	Rattus norvegicus	35-39
31765739-8	2020	In vitro, the expression levels of IGF1 and GLUT1 were inhibited by corticosterone but remained unchanged under caffeine treatment.	Caffeine	112-120	solute carrier family 2 member 1	Rattus norvegicus	44-49
31471674-6	2019	However, caffeine significantly decreased calcitriol-inducible CYP24A1, TNSF11, and SPP1 transcripts in osteoblasts.	Caffeine	9-17	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	63-70
31471674-0	2019	The Effect of Caffeine on Calcitriol-Inducible Vitamin D Receptor-Controlled Gene Expression in Intestinal and Osteoblastic Cells.	Caffeine	14-22	vitamin D receptor	Homo sapiens	47-65
31810406-3	2021	In total, 13 pharmaceuticals were detected in the influent through UHPLC-MS/M - paracetamol and caffeine recorded the highest concentrations, 137.98 and 35.29 microg L-1, respectively.	Caffeine	96-104	immunoglobulin kappa variable 1-16	Homo sapiens	166-169
31849829-0	2019	Caffeine and Primary (Migraine) Headaches-Friend or Foe?	Caffeine	0-8	WAPL cohesin release factor	Homo sapiens	52-55
31471674-3	2019	Therefore, we investigated if caffeine can affect inducible expression of VDR-regulated genes, some of them being involved in bone mineralization process.	Caffeine	30-38	vitamin D receptor	Homo sapiens	74-77
31471674-6	2019	However, caffeine significantly decreased calcitriol-inducible CYP24A1, TNSF11, and SPP1 transcripts in osteoblasts.	Caffeine	9-17	secreted phosphoprotein 1	Homo sapiens	84-88
31471674-5	2019	While caffeine stimulated calcitriol-inducible VDR-dependent nanoluciferase activity in stable reporter cell line IZ-VDRE (derived from LS180), it rather modulated mRNA levels of target genes, like CYP24A1, BGLAP, SPP1, and TNSF11 in LS180 and HOS cells.	Caffeine	6-14	vitamin D receptor	Homo sapiens	47-50
31471674-8	2019	Our in vitro data demonstrate biphasic action of caffeine on the expression of certain calcitriol-inducible VDR-regulated genes in normal human osteoblasts.	Caffeine	49-57	vitamin D receptor	Homo sapiens	108-111
31711939-0	2019	Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody.	Caffeine	0-8	programmed cell death 1	Homo sapiens	46-49
31271106-7	2019	Cellular catalase activity was dropped under hypoxic condition but could be reactivated by caffeine.	Caffeine	91-99	catalase	Homo sapiens	9-17
31271106-8	2019	Hif1a gene and stress-responsive Nrf2 signaling molecule were elevated/activated by hypoxia, but only Nrf2 could be partially recovered by caffeine.	Caffeine	139-147	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
31271106-9	2019	These data suggest that caffeine exhibits anti-fibrotic effect against hypoxia-induced renal fibroblast activation through its antioxidant property to eliminate intracellular ROS, at least in part, via downstream catalase and Nrf2 mechanisms.	Caffeine	24-32	catalase	Homo sapiens	213-221
31271106-9	2019	These data suggest that caffeine exhibits anti-fibrotic effect against hypoxia-induced renal fibroblast activation through its antioxidant property to eliminate intracellular ROS, at least in part, via downstream catalase and Nrf2 mechanisms.	Caffeine	24-32	NFE2 like bZIP transcription factor 2	Homo sapiens	226-230
31735119-9	2019	FGF9 decreased caffeine-induced Ca2+ release from the sarcoplasmic reticulum (SR) of C2C12 myotubes and reduced the expression of genes (i.e. Cacna1s, RyR2, Naftc3) directly associated with intracellular Ca2+ homeostasis.	Caffeine	15-23	fibroblast growth factor 9	Homo sapiens	0-4
31735119-9	2019	FGF9 decreased caffeine-induced Ca2+ release from the sarcoplasmic reticulum (SR) of C2C12 myotubes and reduced the expression of genes (i.e. Cacna1s, RyR2, Naftc3) directly associated with intracellular Ca2+ homeostasis.	Caffeine	15-23	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	142-149
31735119-9	2019	FGF9 decreased caffeine-induced Ca2+ release from the sarcoplasmic reticulum (SR) of C2C12 myotubes and reduced the expression of genes (i.e. Cacna1s, RyR2, Naftc3) directly associated with intracellular Ca2+ homeostasis.	Caffeine	15-23	ryanodine receptor 2	Homo sapiens	151-155
31711939-10	2019	We found that caffeine and anti-PD1 mAb combination therapy significantly increased intra-tumoral TNF-alpha and IFN-gamma levels.	Caffeine	14-22	tumor necrosis factor	Homo sapiens	98-107
31711939-10	2019	We found that caffeine and anti-PD1 mAb combination therapy significantly increased intra-tumoral TNF-alpha and IFN-gamma levels.	Caffeine	14-22	interferon gamma	Homo sapiens	112-121
31711939-11	2019	Our work suggests that administration of caffeine and anti-PD1 mAb harness the therapeutic potential of effector T cells in vivo possibly due to combined blockade of PD1 and adenosine-A2A receptor pathway.	Caffeine	41-49	programmed cell death 1	Homo sapiens	166-169
31711939-11	2019	Our work suggests that administration of caffeine and anti-PD1 mAb harness the therapeutic potential of effector T cells in vivo possibly due to combined blockade of PD1 and adenosine-A2A receptor pathway.	Caffeine	41-49	adenosine A2a receptor	Homo sapiens	174-196
31766549-5	2019	Nonetheless, their use in sensors is becoming more and more common, with the obtainment of very good results in terms of selectivity and sensitivity (up to 5.4 x 10-10 mol L-1 and 1.8 x 10-9 mol L-1 for caffeine and theophylline, respectively).	Caffeine	203-211	L1 cell adhesion molecule	Homo sapiens	172-190
31039625-0	2019	Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach.	Caffeine	14-22	tyrosinase	Homo sapiens	70-80
31039625-5	2019	Results from in silico study indicates that caffeine has comparatively good affinity with collagenase (-4.6 kcal/mol), elastase (-3.36 kcal/mol) and tyrosinase (-2.86 kcal/mol) and formed the stable protein-ligand complex as validated by molecular dynamics simulation (protein-ligand contacts, RMSD, RMSF and secondary structure changes analysis).	Caffeine	44-52	tyrosinase	Homo sapiens	149-159
31039625-6	2019	Moreover, in vitro data showed that caffeine (1000 microg/mL) has statistically significant maximum inhibition activity of 41.86, 36.44 and 13.72% for collagenase, elastase and tyrosinase, respectively.	Caffeine	36-44	tyrosinase	Homo sapiens	177-187
31659899-0	2019	Identification and Characterization of the Tyrosinase Inhibitory Activity of Caffeine from Camellia Pollen.	Caffeine	77-85	tyrosinase	Mus musculus	43-53
31659899-2	2019	A tyrosinase inhibitor was purified from Camellia pollen using high-speed countercurrent chromatography and preparative high-performance liquid chromatography and was identified as caffeine by NMR and mass spectrometry.	Caffeine	181-189	tyrosinase	Mus musculus	2-12
31659899-7	2019	These comprehensive results suggest that caffeine is a strong tyrosinase inhibitor that has the potential to be developed as skin-whitening agents in the cosmetics and pharmaceutical industries or as antibrowning agents in the food industry.	Caffeine	41-49	tyrosinase	Mus musculus	62-72
31659899-4	2019	The caffeine did not interact with copper ions in the active center of the enzyme but could quench fluorescence intensity and change the secondary conformation of this tyrosinase.	Caffeine	4-12	tyrosinase	Mus musculus	168-178
31659899-5	2019	A molecular dynamics simulation showed that caffeine bound this tyrosinase via Lys379, Lys 376, Asp357, Glu356, Thr308, Gln307, Asp312, and Trp358, thus changing the binding sites of l-tyrosine and the loop conformation adjacent to the active center.	Caffeine	44-52	tyrosinase	Mus musculus	64-74
31659899-6	2019	In vitro cell model analysis revealed that caffeine exhibited significant inhibitory effects on both intracellular tyrosinase activity and melanin production of B16-F10 melanoma cells in a concentration-dependent manner.	Caffeine	43-51	tyrosinase	Mus musculus	115-125
31694152-0	2019	Acute Ingestion of a Mixed Flavonoid and Caffeine Supplement Increases Energy Expenditure and Fat Oxidation in Adult Women: A Randomized, Crossover Clinical Trial.	Caffeine	41-49	FAT atypical cadherin 1	Homo sapiens	94-97
31539618-8	2019	In all regions of SSCx, Rt, VB, CM and LGN, GAERS caffeine group had lower c-Fos protein expression comparing to the GAERS control group (p &lt; 0.05).	Caffeine	50-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
31539618-9	2019	Wistar caffeine rats had lower expression of c-Fos protein comparing to the Wistar control group only in SSCx.	Caffeine	7-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
31539618-11	2019	In conclusion differential effects of caffeine in the seizure modulation may involve c-Fos protein activity-dependent protection mechanisms.	Caffeine	38-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-90
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	97-105	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	129-133
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	97-105	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	135-139
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	97-105	Rim8p	Saccharomyces cerevisiae S288C	144-148
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	185-193	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	129-133
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	185-193	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	135-139
31728740-7	2019	Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance.	Caffeine	185-193	Rim8p	Saccharomyces cerevisiae S288C	144-148
31717470-0	2019	Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains.	Caffeine	0-8	toll-like receptor 4	Mus musculus	22-25
31717470-0	2019	Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains.	Caffeine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
31717470-0	2019	Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains.	Caffeine	0-8	toll-like receptor 4	Mus musculus	92-96
31717470-5	2019	Also, we evaluated the expression of nuclear factor erythroid-2-related factor 2 (Nrf2) and the enzyme hemeoxygenase 1 (HO-1) in the mouse groups and found reduced expression of Nrf2 and HO-1 in the LPS-treated mice brains, but they were markedly upregulated in the LPS + caffeine co-treated group.	Caffeine	272-280	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
31717470-5	2019	Also, we evaluated the expression of nuclear factor erythroid-2-related factor 2 (Nrf2) and the enzyme hemeoxygenase 1 (HO-1) in the mouse groups and found reduced expression of Nrf2 and HO-1 in the LPS-treated mice brains, but they were markedly upregulated in the LPS + caffeine co-treated group.	Caffeine	272-280	toll-like receptor 4	Mus musculus	199-202
31717470-6	2019	We also noted enhanced expression of toll-Like Receptor 4 (TLR4), phospho-nuclear factor kappa B (p-NF-kB), and phospho-c-Jun n-terminal kinase (p-JNK) in the LPS-treated mice brains, which was significantly reduced in the LPS + caffeine co-treated group.	Caffeine	229-237	toll-like receptor 4	Mus musculus	159-162
31717470-7	2019	Moreover, we found enhanced expression of Bcl2-associated X, apoptosis regulator (Bax), and cleaved caspase-3, and reduced expression of B-cell lymphoma 2 (Bcl-2) in the LPS-treated group, which were markedly reversed in the LPS + caffeine co-treated group.	Caffeine	231-239	B cell leukemia/lymphoma 2	Mus musculus	137-154
31717470-7	2019	Moreover, we found enhanced expression of Bcl2-associated X, apoptosis regulator (Bax), and cleaved caspase-3, and reduced expression of B-cell lymphoma 2 (Bcl-2) in the LPS-treated group, which were markedly reversed in the LPS + caffeine co-treated group.	Caffeine	231-239	B cell leukemia/lymphoma 2	Mus musculus	156-161
31717470-7	2019	Moreover, we found enhanced expression of Bcl2-associated X, apoptosis regulator (Bax), and cleaved caspase-3, and reduced expression of B-cell lymphoma 2 (Bcl-2) in the LPS-treated group, which were markedly reversed in the LPS + caffeine co-treated group.	Caffeine	231-239	toll-like receptor 4	Mus musculus	170-173
31717470-8	2019	Furthermore, we analyzed the expression of synaptic proteins in the treated groups and found a marked reduction in the expression of synaptic markers in the LPS-treated group; these were significantly upregulated in the LPS + caffeine co-treated group.	Caffeine	226-234	toll-like receptor 4	Mus musculus	157-160
31717470-8	2019	Furthermore, we analyzed the expression of synaptic proteins in the treated groups and found a marked reduction in the expression of synaptic markers in the LPS-treated group; these were significantly upregulated in the LPS + caffeine co-treated group.	Caffeine	226-234	toll-like receptor 4	Mus musculus	220-223
31717470-9	2019	In summary, we conclude that caffeine may inhibit LPS-induced oxidative stress, neuroinflammation, and synaptic dysfunction.	Caffeine	29-37	toll-like receptor 4	Mus musculus	50-53
31690049-8	2019	In comparison to the placebo, a two-way ANOVA showed that the ingestion of 3 mg/kg/bm of caffeine increased mean velocity at 60% 1RM in EFP (Delta = 1.4 +- 2.7%, p = 0.04; ES: 0.2 +- 0.2) and LFP (Delta = 5.0 +- 10.4%, p = 0.04; ES: 0.3 +- 0.4).	Caffeine	89-97	tripartite motif containing 25	Homo sapiens	136-139
31684105-0	2019	Effect of Caffeine and Other Methylxanthines on Abeta-Homeostasis in SH-SY5Y Cells.	Caffeine	10-18	amyloid beta precursor protein	Homo sapiens	48-53
31684105-7	2019	Breaking down the molecular mechanism, caffeine increased protein stability of the major alpha-secretase ADAM10, downregulated BACE1 expression and directly decreased beta-secretase activity.	Caffeine	39-47	ADAM metallopeptidase domain 10	Homo sapiens	105-111
31684105-7	2019	Breaking down the molecular mechanism, caffeine increased protein stability of the major alpha-secretase ADAM10, downregulated BACE1 expression and directly decreased beta-secretase activity.	Caffeine	39-47	beta-secretase 1	Homo sapiens	127-132
31690049-8	2019	In comparison to the placebo, a two-way ANOVA showed that the ingestion of 3 mg/kg/bm of caffeine increased mean velocity at 60% 1RM in EFP (Delta = 1.4 +- 2.7%, p = 0.04; ES: 0.2 +- 0.2) and LFP (Delta = 5.0 +- 10.4%, p = 0.04; ES: 0.3 +- 0.4).	Caffeine	89-97	lamin A/C	Homo sapiens	192-195
31599075-2	2019	We examined whether gender differences existed in the relationship between the combined use of alcohol and caffeine (Alc + Caff) and risk for injury.	Caffeine	107-115	allantoicase	Homo sapiens	117-120
31646844-9	2019	On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist.	Caffeine	95-103	adenosine A1 receptor	Mus musculus	145-162
31646844-9	2019	On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist.	Caffeine	95-103	adenosine A2a receptor	Mus musculus	167-171
31646844-9	2019	On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist.	Caffeine	95-103	adenosine A1 receptor	Mus musculus	159-162
31646844-9	2019	On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist.	Caffeine	95-103	adenosine A2a receptor	Mus musculus	255-259
31339646-1	2019	We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N-acetyltransferase 2 (NAT2), using caffeine as a probe.	Caffeine	158-166	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-85
31670366-0	2019	Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKalpha-LXRalpha/SREBP-1c pathway in high-fat diet-induced obese mice.	Caffeine	46-54	sterol regulatory element binding transcription factor 1	Mus musculus	102-110
31670366-2	2019	The combination of CGA and caffeine effectively decreased body weight gain, intraperitoneal adipose tissue weight, serum LDL-c, FFA, TC, TG, leptin, IL-6 concentrations, and hepatic TG and TC levels and increased the serum adiponectin level.	Caffeine	27-35	leptin	Mus musculus	141-147
31670366-3	2019	The CGA and caffeine combination also promoted the phosphorylation of AMPKalpha, inhibited the expressions of transcriptional regulators (SREBP-1c and LXRalpha), and decreased the expressions of FAS and HMGR.	Caffeine	12-20	sterol regulatory element binding transcription factor 1	Mus musculus	138-146
31670366-3	2019	The CGA and caffeine combination also promoted the phosphorylation of AMPKalpha, inhibited the expressions of transcriptional regulators (SREBP-1c and LXRalpha), and decreased the expressions of FAS and HMGR.	Caffeine	12-20	nuclear receptor subfamily 1, group H, member 3	Mus musculus	151-159
31670366-2	2019	The combination of CGA and caffeine effectively decreased body weight gain, intraperitoneal adipose tissue weight, serum LDL-c, FFA, TC, TG, leptin, IL-6 concentrations, and hepatic TG and TC levels and increased the serum adiponectin level.	Caffeine	27-35	interleukin 6	Mus musculus	149-153
31670366-4	2019	Besides, the expressions of ACO, ATGL and HSL were increased by the CGA and caffeine combinations.	Caffeine	76-84	patatin-like phospholipase domain containing 2	Mus musculus	33-37
31670366-4	2019	Besides, the expressions of ACO, ATGL and HSL were increased by the CGA and caffeine combinations.	Caffeine	76-84	lipase, hormone sensitive	Mus musculus	42-45
31670366-2	2019	The combination of CGA and caffeine effectively decreased body weight gain, intraperitoneal adipose tissue weight, serum LDL-c, FFA, TC, TG, leptin, IL-6 concentrations, and hepatic TG and TC levels and increased the serum adiponectin level.	Caffeine	27-35	adiponectin, C1Q and collagen domain containing	Mus musculus	223-234
31670366-5	2019	The results indicated that the combination of CGA and caffeine had anti-obesity effects and regulated lipid metabolism in high-fat diet-induced obese mice via the AMPKalpha-LXRalpha/SREBP-1c signaling pathway.	Caffeine	54-62	sterol regulatory element binding transcription factor 1	Mus musculus	182-190
31839857-7	2019	While results were not significant, the treatment main effect approached significance (p = 0.07) in set 2 for the delta of distances when comparing caffeine (96.2 cm +- 19.8) versus placebo (107.1 cm +- 16.3).	Caffeine	148-156	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	100-105
31479682-15	2019	In contrast, caffeine per se decreased GR and MR expression and their ratio in unstressed animals.	Caffeine	13-21	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	39-41
29514562-9	2019	In addition, caffeine restored the elevated level of TNF-alpha in the hippocampus and striatum.	Caffeine	13-21	tumor necrosis factor	Rattus norvegicus	53-62
31479682-15	2019	In contrast, caffeine per se decreased GR and MR expression and their ratio in unstressed animals.	Caffeine	13-21	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	46-48
31352502-4	2019	In this work, an analytical method has been developed and validated for the simultaneous extraction and determination of the main metabolites of the pharmaceuticals diclofenac, ibuprofen, sulfamethoxazole, carbamazepine and caffeine and of the parabens methylparaben and propylparaben and their parent compounds in wastewater and tap water samples.	Caffeine	224-232	nuclear RNA export factor 1	Homo sapiens	330-333
31781344-8	2019	After administration of a caffeine and/or melatonin supplement, there was a significant increase in progressive motility in the CAF (p = 0.005) and CM (p = 0.048) groups, as well as mitochondrial activity in the CM group (p &lt; 0.05).	Caffeine	26-34	lysine acetyltransferase 2B	Homo sapiens	128-131
31306741-0	2019	Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring rats.	Caffeine	92-100	Kruppel like factor 4	Rattus norvegicus	26-30
30958066-1	2019	PURPOSE: The aim of this study was to determine the effects of low dose caffeine supplementation (3 mg/kg/BM) consumed one hour before the experiment on rating of perceived exertion (RPE), skills performance, and physicality in male collegiate ice hockey players.	Caffeine	72-80	ribulose-phosphate 3-epimerase	Mandrillus leucophaeus	183-186
30958066-6	2019	RESULTS: RPE was significantly greater in the caffeine (11.3 +- 2.0) vs. placebo (9.9 +- 1.9) condition post-practice (p=.002), with a trend toward greater RPE in caffeine (16.9 +- 1.8) vs. placebo (15.7 +- 2.8) post-scrimmage (p=.050).	Caffeine	46-54	ribulose-phosphate 3-epimerase	Mandrillus leucophaeus	9-12
30958066-6	2019	RESULTS: RPE was significantly greater in the caffeine (11.3 +- 2.0) vs. placebo (9.9 +- 1.9) condition post-practice (p=.002), with a trend toward greater RPE in caffeine (16.9 +- 1.8) vs. placebo (15.7 +- 2.8) post-scrimmage (p=.050).	Caffeine	46-54	ribulose-phosphate 3-epimerase	Mandrillus leucophaeus	156-159
30958066-6	2019	RESULTS: RPE was significantly greater in the caffeine (11.3 +- 2.0) vs. placebo (9.9 +- 1.9) condition post-practice (p=.002), with a trend toward greater RPE in caffeine (16.9 +- 1.8) vs. placebo (15.7 +- 2.8) post-scrimmage (p=.050).	Caffeine	163-171	ribulose-phosphate 3-epimerase	Mandrillus leucophaeus	9-12
30958066-9	2019	CONCLUSIONS: A low dose of caffeine has limited impact on sport-specific skill performance and RPE but may enhance physicality during ice hockey scrimmages.	Caffeine	27-35	ribulose-phosphate 3-epimerase	Mandrillus leucophaeus	95-98
31656914-2	2019	The superimposed antioxidant activity of caffeine with SOD was investigated by detecting the concentration of malondialdehyde (MDA) present in cells, which was induced by hyperthermia and heavy metal exposure.	Caffeine	41-49	superoxide dismutase 1	Homo sapiens	55-58
31656914-3	2019	The interactions between the SOD enzyme and caffeine were researched by ultraviolet spectrum, fluorescence spectrum, and molecular computation.	Caffeine	44-52	superoxide dismutase 1	Homo sapiens	29-32
31656914-5	2019	The fluorescence spectroscopy and molecular computation results show that the mixture of caffeine and SOD can result in the formation of a 1:1 complex through hydrogen bond and van der Waals forces spontaneously.	Caffeine	89-97	superoxide dismutase 1	Homo sapiens	102-105
31656914-6	2019	The binding constant (K a) of caffeine with SOD at five different temperatures are 4.41 x 104, 3.30 x 104, 2.29 x 104, 1.71 x 104, and 1.17 x 104 L/mol.	Caffeine	30-38	superoxide dismutase 1	Homo sapiens	44-47
31656914-9	2019	The combination of caffeine with SOD can change the conformation and microenvironment of SOD but does not change the activity of SOD.	Caffeine	19-27	superoxide dismutase 1	Homo sapiens	89-92
31656914-9	2019	The combination of caffeine with SOD can change the conformation and microenvironment of SOD but does not change the activity of SOD.	Caffeine	19-27	superoxide dismutase 1	Homo sapiens	89-92
31422100-4	2019	In this study, our aim was to evaluate neuroprotective effect rendered by edaravone, a potent free radical scavenger in combination with caffeine, an effective inhibitor of adenosine A2A receptor as well as a proven antioxidant.	Caffeine	137-145	adenosine A2a receptor	Rattus norvegicus	173-195
31656914-1	2019	The binding characteristics and superimposed antioxidant properties of caffeine combined with copper/zinc superoxide dismutase (SOD) were studied.	Caffeine	71-79	superoxide dismutase 1	Homo sapiens	128-131
31680863-6	2019	Electrophysiological recordings of hippocampal CA1 pyramidal cells in vitro revealed that early life exposure to caffeine changed the way the glutamatergic and GABAergic drives were modified by the Tau pathology.	Caffeine	113-121	carbonic anhydrase 1	Mus musculus	47-50
30427383-9	2019	Caffeine concentrations in water can be used as predictors of BPA concentrations above 10 ng L-1, the lower concentration of ecotoxicological risk, with specificity of 66.7% and sensitivity of 70.4%.	Caffeine	0-8	immunoglobulin kappa variable 1-16	Homo sapiens	93-96
31519293-12	2019	In all cases, CYP1A2 activity was decreased with an increasing inhibitor concentration, confirming the inhibition of caffeine metabolism in vivo.	Caffeine	117-125	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
31123759-3	2019	The purpose of this study was to evaluate the potential for a caffeine metabolic ratio to describe variability in CYP3A activity.	Caffeine	62-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-119
31803568-10	2019	Combined injected (nicotine + caffeine) group, some fibers exhibited deep acidophilic cytoplasm with flat peripheral nuclei and apparent increase of the CD68 positive cells.	Caffeine	30-38	Cd68 molecule	Rattus norvegicus	153-157
31181574-0	2019	Caffeine and the Dyskinesia Related to Mutations in the ADCY5 Gene.	Caffeine	0-8	adenylate cyclase 5	Homo sapiens	56-61
31044239-6	2019	Mutant RyR1 channels incorporated into lipid bilayers were less sensitive to calcium and caffeine, but no change in single-channel conductance was observed.	Caffeine	89-97	ryanodine receptor 1, skeletal muscle	Mus musculus	7-11
31310752-0	2019	Caffeine-enhanced anti-tumor immune response through decreased expression of PD1 on infiltrated cytotoxic T lymphocytes.	Caffeine	0-8	programmed cell death 1	Homo sapiens	77-80
31310752-11	2019	We found that TNF-alpha and IFN-gamma levels were significantly higher in caffeine-treated groups.	Caffeine	74-82	tumor necrosis factor	Homo sapiens	14-23
31310752-11	2019	We found that TNF-alpha and IFN-gamma levels were significantly higher in caffeine-treated groups.	Caffeine	74-82	interferon gamma	Homo sapiens	28-37
31123759-4	2019	METHODS: The metabolic ratio 1,3,7-trimethyluric acid (TMU) to caffeine was evaluated as a biomarker to describe variability in CYP3A activity in a cohort (n = 28) of healthy 21 to 35-year-old males.	Caffeine	63-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	128-133
31123759-9	2019	CONCLUSION: BSV in CYP3A activity was well described by caffeine/TMU ratios pre- and post-induction.	Caffeine	56-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	19-24
31443548-0	2019	Effect of Caffeine Copigmentation of Anthocyanin Dyes on DSSC Efficiency.	Caffeine	10-18	DDB1 and CUL4 associated factor 7	Homo sapiens	37-48
31190057-6	2019	RESULTS: In the UK Biobank, we identified 6 independent GWAS variants, including those implicated for caffeine (ARID3B/CYP1A1), carbohydrate metabolism (FGF21), schizophrenia (ZNF804A), and encoding enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), which regulates the pace of the circadian clock.	Caffeine	102-110	AT-rich interaction domain 3B	Homo sapiens	112-118
31523679-6	2019	Dopamine and prolactin were significantly higher in the caffeine ingestion group than in the control group at the Post time point (P&lt;0.001).	Caffeine	56-64	prolactin	Homo sapiens	13-22
31523679-8	2019	Prolactin responses during passive heat loading were also significantly related to caffeine ingestion in this study.	Caffeine	83-91	prolactin	Homo sapiens	0-9
31523679-9	2019	However, the inhibitory effects of dopamine on prolactin by caffeine remain to be elucidated.	Caffeine	60-68	prolactin	Homo sapiens	47-56
31194991-0	2019	Activation of Cav1.2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries.	Caffeine	67-75	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	14-20
31194991-0	2019	Activation of Cav1.2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries.	Caffeine	67-75	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	25-29
31194991-10	2019	Therefore, caffeine promoted Ca2+-influx via TRPs and Cav1.2, and hyperpolarization through the activation of BKCa, inducing negative feedback of TC.	Caffeine	11-19	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	54-60
31194991-10	2019	Therefore, caffeine promoted Ca2+-influx via TRPs and Cav1.2, and hyperpolarization through the activation of BKCa, inducing negative feedback of TC.	Caffeine	11-19	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	110-114
31194991-12	2019	The evidence of the negative feedback of contraction via TRP-Cav1.2-BKCa provides a new perspective for understanding the mechanism involved in the vascular responses triggered by caffeine.	Caffeine	180-188	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	61-67
31194991-12	2019	The evidence of the negative feedback of contraction via TRP-Cav1.2-BKCa provides a new perspective for understanding the mechanism involved in the vascular responses triggered by caffeine.	Caffeine	180-188	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	68-72
31190057-6	2019	RESULTS: In the UK Biobank, we identified 6 independent GWAS variants, including those implicated for caffeine (ARID3B/CYP1A1), carbohydrate metabolism (FGF21), schizophrenia (ZNF804A), and encoding enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), which regulates the pace of the circadian clock.	Caffeine	102-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	119-125
31140953-5	2019	Under the optimum conditions, the proposed method allowed the determination of caffeine with limits of detection (LOD, 3sblank/m) and quantification (LOQ, 3sblank/m) of 7.5 and 25.0 microg L-1, respectively.	Caffeine	79-87	immunoglobulin kappa variable 1-16	Homo sapiens	189-192
31199895-8	2019	These results show that the effects of caffeine on synaptic transmission and plasticity in the hippocampus are selectively mediated by antagonizing adenosine receptors, where A1R are responsible for the impact of caffeine on synaptic transmission and A2AR regulate the impact of caffeine on LTP.	Caffeine	39-47	adenosine A2a receptor	Mus musculus	251-255
31166712-4	2019	Caffeine-induced Ca2+ release studies indicated that RyR1-Q3970K formed caffeine-sensitive, Ca2+-conducting channel in HEK293 cells.	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	53-57
31166712-4	2019	Caffeine-induced Ca2+ release studies indicated that RyR1-Q3970K formed caffeine-sensitive, Ca2+-conducting channel in HEK293 cells.	Caffeine	72-80	ryanodine receptor 1	Homo sapiens	53-57
31166712-5	2019	However, in single-channel recordings, RyR1-Q3970K displayed low Ca2+-dependent channel activity and greatly reduced activation by caffeine or ATP.	Caffeine	131-139	ryanodine receptor 1	Homo sapiens	39-43
31166712-7	2019	RyR1-Q3970E also formed caffeine-induced Ca2+ release in HEK293 cells and exhibited low activity in the presence of the activating ligand Ca2+ but, in contrast to RyR1-Q3970K, was activated by ATP and caffeine in single-channel recordings.	Caffeine	24-32	ryanodine receptor 1	Homo sapiens	0-4
31166712-7	2019	RyR1-Q3970E also formed caffeine-induced Ca2+ release in HEK293 cells and exhibited low activity in the presence of the activating ligand Ca2+ but, in contrast to RyR1-Q3970K, was activated by ATP and caffeine in single-channel recordings.	Caffeine	201-209	ryanodine receptor 1	Homo sapiens	0-4
31368376-7	2021	Caffeine (CAF; 8 mg/kg, i.p.	Caffeine	0-8	caffeine susceptibility	Mus musculus	10-13
31140953-6	2019	For 40 microg L-1 and 100 microg L-1 of caffeine (n = 5), relative standard deviations (RSDs%) and recoveries% were 1.2-1.6% and 96.7-98.2%, respectively.	Caffeine	40-48	immunoglobulin kappa variable 1-16	Homo sapiens	14-25
31127943-9	2019	Pretreatment with DDx (0.1-10 microM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner.	Caffeine	125-133	ryanodine receptor 1, skeletal muscle	Mus musculus	113-116
31278385-7	2019	By contrast, the pore of the ATP, caffeine and Ca2+-activated channel remains open in the presence of Ca2+-CaM, which suggests that Ca2+-CaM is one of the many competing modulators of RyR2 gating.	Caffeine	34-42	calmodulin 1	Homo sapiens	107-110
31278385-7	2019	By contrast, the pore of the ATP, caffeine and Ca2+-activated channel remains open in the presence of Ca2+-CaM, which suggests that Ca2+-CaM is one of the many competing modulators of RyR2 gating.	Caffeine	34-42	calmodulin 1	Homo sapiens	137-140
31278385-7	2019	By contrast, the pore of the ATP, caffeine and Ca2+-activated channel remains open in the presence of Ca2+-CaM, which suggests that Ca2+-CaM is one of the many competing modulators of RyR2 gating.	Caffeine	34-42	ryanodine receptor 2	Homo sapiens	184-188
31362742-7	2019	RESULTS: Caffeine and hyperoxia in itself upregulate HIF-2alpha and vascular endothelial growth factor gene expression.	Caffeine	9-17	endothelial PAS domain protein 1	Mus musculus	53-63
31362742-8	2019	Protein expression of HIF-2alpha and VEGFR1 were higher in hyperoxia/caffeine and angiopoietin-1 lower in hyperoxia.	Caffeine	69-77	endothelial PAS domain protein 1	Mus musculus	22-32
31362742-8	2019	Protein expression of HIF-2alpha and VEGFR1 were higher in hyperoxia/caffeine and angiopoietin-1 lower in hyperoxia.	Caffeine	69-77	FMS-like tyrosine kinase 1	Mus musculus	37-43
30999827-4	2019	Although caffeine is not an endogenous metabolite in Arabidopsis and rice, AtPUP1 and OsPUP7 were suggested to transport caffeine.	Caffeine	121-129	purine permease 1	Arabidopsis thaliana	75-81
31307409-12	2019	In mitochondrial depolarization and caspase 3/7 activity assay revealed that caffeine citrate had most strong effect as a combination drug than caffeine and citric acid in apoptosis associated with decreased mitochondrial membrane potential.	Caffeine	77-85	caspase 3	Homo sapiens	36-45
31077720-9	2019	In plasma, caffeine significantly elevated the miR-126-3p and miR-132-3p levels and decreased miR-155-5p levels.	Caffeine	11-19	microRNA 155	Rattus norvegicus	94-101
31324842-0	2019	Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine"s Effect on Postprandial Glycaemia.	Caffeine	54-62	adenosine A2a receptor	Homo sapiens	25-32
31324842-0	2019	Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine"s Effect on Postprandial Glycaemia.	Caffeine	54-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
31324842-1	2019	The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects via antagonist binding to adenosine A2a receptors (ADORA2A).	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-36
31324842-1	2019	The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects via antagonist binding to adenosine A2a receptors (ADORA2A).	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44
31324842-1	2019	The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects via antagonist binding to adenosine A2a receptors (ADORA2A).	Caffeine	99-107	adenosine A2a receptor	Homo sapiens	186-193
31132250-4	2019	We used BLUES to investigate binding modes of caffeine in the active site of its metabolizing enzyme Cytochrome P450 1A2 with the aim of elucidating metabolite-formation profiles at different concentrations.	Caffeine	46-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	101-120
31360202-10	2019	The administration of caffeine resulted in decreased activity of SOD, CAT and GPx.	Caffeine	22-30	catalase	Rattus norvegicus	70-73
31294114-5	2019	IB3.1 CF cells with a nonsense mutation were treated with caffeine to attenuate the Nonsense-Mediated mRNA Decay (NMD) activity and thus enhance the stability of the nonsense (ns)-CFTR-mRNA to be targeted by Ataluren.	Caffeine	58-66	CF transmembrane conductance regulator	Homo sapiens	180-184
31141788-0	2019	The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure.	Caffeine	66-74	insulin-like growth factor 1	Rattus norvegicus	7-11
30879206-0	2019	Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors.	Caffeine	0-8	CREB regulated transcription coactivator 2	Mus musculus	27-33
30879206-4	2019	We found that caffeine inhibits phosphatidylinositol 3-kinase (PI3K) and mechanistic target of rapamycin complex 2 (mTORC2).	Caffeine	14-22	CREB regulated transcription coactivator 2	Mus musculus	116-122
30822423-0	2019	Caffeine inhibits hypoxia-induced nuclear accumulation in HIF-1alpha and promotes neonatal neuronal survival.	Caffeine	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
30822423-3	2019	Caffeine releases respiratory arrest by competing with adenosine for binding to adenosine A1 and A2A receptors (A1R and A2AR).	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	120-124
30822423-9	2019	Furthermore, caffeine (200 muM) at a dose twice higher than the clinically relevant dose (36-130 muM) had minor or no effects on several basic neuronal functions, such as neurite outgrowth, synapse formation, expression of A1R and transcription of CREB-1 and c-Fos, further supporting the safety of caffeine for clinical use.	Caffeine	13-21	latexin	Homo sapiens	27-30
30822423-9	2019	Furthermore, caffeine (200 muM) at a dose twice higher than the clinically relevant dose (36-130 muM) had minor or no effects on several basic neuronal functions, such as neurite outgrowth, synapse formation, expression of A1R and transcription of CREB-1 and c-Fos, further supporting the safety of caffeine for clinical use.	Caffeine	13-21	latexin	Homo sapiens	97-100
30822423-11	2019	Subsequent treatment with caffeine at a concentration of 100 muM alleviated CoCl2-induced cell death and prevented nuclear accumulation of HIF-1alpha.	Caffeine	26-34	latexin	Homo sapiens	61-64
30822423-11	2019	Subsequent treatment with caffeine at a concentration of 100 muM alleviated CoCl2-induced cell death and prevented nuclear accumulation of HIF-1alpha.	Caffeine	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
30822423-12	2019	Consistently, caffeine treatment in early postnatal life of neonatal mice (P4-P7) also prevented subsequent hypoxia-induced nuclear increase of HIF-1alpha.	Caffeine	14-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	144-154
30879206-5	2019	Both PI3K and mTORC2 are essential for the chemoattractant-stimulated cAMP production, thereby providing a mechanism for the caffeine-mediated inhibition of cAMP synthesis.	Caffeine	125-133	CREB regulated transcription coactivator 2	Mus musculus	14-20
30879206-6	2019	Our results also reveal that caffeine treatment of cells leads to an increase in cAMP-induced RasG and Rap1 activation, and inhibition of the PKA, cGMP, MyoII, and ERK1 responses.	Caffeine	29-37	RAP1A, member of RAS oncogene family	Homo sapiens	103-107
30879206-6	2019	Our results also reveal that caffeine treatment of cells leads to an increase in cAMP-induced RasG and Rap1 activation, and inhibition of the PKA, cGMP, MyoII, and ERK1 responses.	Caffeine	29-37	mitogen-activated protein kinase 3	Homo sapiens	164-168
30879206-7	2019	Finally, we observed that caffeine has opposite effects on F-actin and ERK2 depending on the assay and Dictyostelium strain used, respectively.	Caffeine	26-34	mitogen-activated protein kinase 1	Homo sapiens	71-75
30879206-8	2019	Altogether, our findings reveal that caffeine considerably affects the cAMP-induced chemotactic signaling pathways in Dictyostelium, most likely acting through multiple targets that include PI3K and mTORC2.	Caffeine	37-45	CREB regulated transcription coactivator 2	Mus musculus	199-205
29728279-2	2019	Data gathered indicated that caffeine, paracetamol, atenolol, ibuprofen, cephalexin and bisphenol A occur in the mug L-1 range in streams near urban areas.	Caffeine	29-37	immunoglobulin kappa variable 1-16	Homo sapiens	117-120
31160916-8	2019	Results: The distinct metabolites between PDR and NDR groups were significantly enriched in 9 KEGG pathways (P &lt; 0.05, impact &gt; 0.1), namely, alanine, aspartate and glutamate metabolism, caffeine metabolism, beta-alanine metabolism, purine metabolism, cysteine and methionine metabolism, sulfur metabolism, sphingosine metabolism, and arginine and proline metabolism.	Caffeine	193-201	serine/threonine kinase 38	Homo sapiens	50-53
31235722-5	2019	Stem cell-derived adipocytes exposed to caffeine (1 mM) showed increased UCP1 protein abundance and cell metabolism with enhanced oxygen consumption and proton leak.	Caffeine	40-48	uncoupling protein 1	Homo sapiens	73-77
31235722-7	2019	Caffeine also increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha expression and mitochondrial biogenesis, together with a number of BAT selective and beige gene markers.	Caffeine	0-8	PPARG coactivator 1 alpha	Homo sapiens	24-92
30808064-4	2019	KEY RESULTS: Caffeine (10 mM) markedly increased mouse duodenal short-circuit current (Isc ), which was attenuated by a removal of either Cl- or HCO3 - , Ca2+ -free serosal solutions and selective blockers of store-operated Ca2+ channels (SOC/Ca2+ release-activated Ca2+ channels), and knockdown of Orai1 channels on the serosal side of duodenal tissues.	Caffeine	13-21	ORAI calcium release-activated calcium modulator 1	Mus musculus	299-304
30808064-6	2019	Caffeine-stimulated duodenal Isc was inhibited by the endoplasmic reticulum Ca2+ chelator (N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine), selective blockers (ruthenium red and dantrolene) of ryanodine receptors (RyR), and of Ca2+ -activated Cl- channels (niflumic acid and T16A).	Caffeine	0-8	ryanodine receptor 1, skeletal muscle	Mus musculus	197-216
30808064-6	2019	Caffeine-stimulated duodenal Isc was inhibited by the endoplasmic reticulum Ca2+ chelator (N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine), selective blockers (ruthenium red and dantrolene) of ryanodine receptors (RyR), and of Ca2+ -activated Cl- channels (niflumic acid and T16A).	Caffeine	0-8	ryanodine receptor 1, skeletal muscle	Mus musculus	218-221
30808064-10	2019	CONCLUSIONS AND IMPLICATIONS: Caffeine stimulated intestinal anion secretion mainly through the RyR/Orai1/Ca2+ signalling pathway.	Caffeine	30-38	ryanodine receptor 1, skeletal muscle	Mus musculus	96-99
30808064-10	2019	CONCLUSIONS AND IMPLICATIONS: Caffeine stimulated intestinal anion secretion mainly through the RyR/Orai1/Ca2+ signalling pathway.	Caffeine	30-38	ORAI calcium release-activated calcium modulator 1	Mus musculus	100-105
30808064-12	2019	Our findings suggest that a caffeine-mediated RyR/Orai1/Ca2+ pathway could provide novel potential drug targets to control intestinal anion secretion.	Caffeine	28-36	ryanodine receptor 1, skeletal muscle	Mus musculus	46-49
30808064-12	2019	Our findings suggest that a caffeine-mediated RyR/Orai1/Ca2+ pathway could provide novel potential drug targets to control intestinal anion secretion.	Caffeine	28-36	ORAI calcium release-activated calcium modulator 1	Mus musculus	50-55
29295636-9	2019	CONCLUSIONS: Caffeine seems encouraging for the prevention and treatment of bilirubin neurotoxicity in rats by means of its antiapoptotic, antioxidant, anti-inflammatory, anti-nitrosative, and anti-TLR-4 properties.	Caffeine	13-21	toll-like receptor 4	Rattus norvegicus	198-203
30173351-1	2019	Caffeine is a well-established ergogenic aid, demonstrated to enhance performance across a wide range of capacities through a variety of mechanisms.	Caffeine	0-8	activation induced cytidine deaminase	Homo sapiens	41-44
31360100-0	2019	Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-kappaB and A2aR Signaling in LPS-Induced THP-1 Macrophages.	Caffeine	0-8	NLR family pyrin domain containing 3	Homo sapiens	18-23
31360100-0	2019	Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-kappaB and A2aR Signaling in LPS-Induced THP-1 Macrophages.	Caffeine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	68-77
31360100-0	2019	Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-kappaB and A2aR Signaling in LPS-Induced THP-1 Macrophages.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	82-86
31360100-0	2019	Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-kappaB and A2aR Signaling in LPS-Induced THP-1 Macrophages.	Caffeine	0-8	GLI family zinc finger 2	Homo sapiens	112-117
31360100-4	2019	In the present study, we aimed to investigate the effects of caffeine on NLRP3 inflammasome activation in LPS-induced THP-1 macrophages and to explore the underlying the detailed mechanism.	Caffeine	61-69	NLR family pyrin domain containing 3	Homo sapiens	73-78
31360100-4	2019	In the present study, we aimed to investigate the effects of caffeine on NLRP3 inflammasome activation in LPS-induced THP-1 macrophages and to explore the underlying the detailed mechanism.	Caffeine	61-69	GLI family zinc finger 2	Homo sapiens	118-123
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	NLR family pyrin domain containing 3	Homo sapiens	45-50
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	PYD and CARD domain containing	Homo sapiens	63-66
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	caspase 1	Homo sapiens	88-97
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	interleukin 1 beta	Homo sapiens	131-139
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	interleukin 18	Homo sapiens	144-149
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	GLI family zinc finger 2	Homo sapiens	163-168
31360100-6	2019	Caffeine also markedly decreased the phosphorylation levels of MAPK and NF-kappaB pathway members, further suppressing the translocation of NF-kappaB in THP-1 macrophages.	Caffeine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	72-81
31360100-6	2019	Caffeine also markedly decreased the phosphorylation levels of MAPK and NF-kappaB pathway members, further suppressing the translocation of NF-kappaB in THP-1 macrophages.	Caffeine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	140-149
31360100-6	2019	Caffeine also markedly decreased the phosphorylation levels of MAPK and NF-kappaB pathway members, further suppressing the translocation of NF-kappaB in THP-1 macrophages.	Caffeine	0-8	GLI family zinc finger 2	Homo sapiens	153-158
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	Caffeine	27-35	adenosine A2a receptor	Homo sapiens	48-70
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	Caffeine	27-35	adenosine A2a receptor	Homo sapiens	72-76
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	Caffeine	27-35	caspase 1	Homo sapiens	110-119
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	Caffeine	27-35	GLI family zinc finger 2	Homo sapiens	134-139
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	Caffeine	39-47	NLR family pyrin domain containing 3	Homo sapiens	57-62
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	Caffeine	39-47	nuclear factor kappa B subunit 1	Homo sapiens	107-116
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	Caffeine	39-47	adenosine A2a receptor	Homo sapiens	131-135
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	Caffeine	39-47	GLI family zinc finger 2	Homo sapiens	177-182
30362583-0	2019	Cell survival controlled by lens-derived Sema3A-Nrp1 is vital on caffeine-suppressed corneal innervation during chick organogenesis.	Caffeine	65-73	semaphorin 3A	Gallus gallus	41-47
30362583-0	2019	Cell survival controlled by lens-derived Sema3A-Nrp1 is vital on caffeine-suppressed corneal innervation during chick organogenesis.	Caffeine	65-73	neuropilin 1	Gallus gallus	48-52
30362583-4	2019	Whole-mount in situ hybridization against semaphorin 3A (Sema3A) and neuropilin-1 (Nrp1) showed that both caffeine and 2,2"-azobis(2-methylpropionamidine) dihydrochloride (AAPH, a free radical generator) administration upregulates the expression of both Sema3A and Nrp1.	Caffeine	106-114	semaphorin 3A	Gallus gallus	42-55
30362583-4	2019	Whole-mount in situ hybridization against semaphorin 3A (Sema3A) and neuropilin-1 (Nrp1) showed that both caffeine and 2,2"-azobis(2-methylpropionamidine) dihydrochloride (AAPH, a free radical generator) administration upregulates the expression of both Sema3A and Nrp1.	Caffeine	106-114	semaphorin 3A	Gallus gallus	57-63
30362583-4	2019	Whole-mount in situ hybridization against semaphorin 3A (Sema3A) and neuropilin-1 (Nrp1) showed that both caffeine and 2,2"-azobis(2-methylpropionamidine) dihydrochloride (AAPH, a free radical generator) administration upregulates the expression of both Sema3A and Nrp1.	Caffeine	106-114	neuropilin 1	Gallus gallus	69-81
30362583-4	2019	Whole-mount in situ hybridization against semaphorin 3A (Sema3A) and neuropilin-1 (Nrp1) showed that both caffeine and 2,2"-azobis(2-methylpropionamidine) dihydrochloride (AAPH, a free radical generator) administration upregulates the expression of both Sema3A and Nrp1.	Caffeine	106-114	neuropilin 1	Gallus gallus	83-87
30362583-7	2019	Knocking-down Sema3A through transfection with Sema3A-siRNA dramatically decreased the responsiveness of cells to caffeine administration, as well as cell apoptosis.	Caffeine	114-122	semaphorin 3A	Gallus gallus	14-20
30362583-7	2019	Knocking-down Sema3A through transfection with Sema3A-siRNA dramatically decreased the responsiveness of cells to caffeine administration, as well as cell apoptosis.	Caffeine	114-122	semaphorin 3A	Gallus gallus	47-53
30362583-9	2019	Taken together, we speculate here that caffeine-enhanced reactive oxygen species upregulates Sema3A-Nrp1 expression in the lens and periocular tissues, resulting in corneal cell apoptosis, accompanied by its chemorepellent role on the invasion of the developing cornea by trigeminal sensory fibers.	Caffeine	39-47	semaphorin 3A	Gallus gallus	93-99
30362583-9	2019	Taken together, we speculate here that caffeine-enhanced reactive oxygen species upregulates Sema3A-Nrp1 expression in the lens and periocular tissues, resulting in corneal cell apoptosis, accompanied by its chemorepellent role on the invasion of the developing cornea by trigeminal sensory fibers.	Caffeine	39-47	neuropilin 1	Gallus gallus	100-104
31121943-9	2019	Conclusions: Protein-drug interaction analysis revealed PDE9A has interaction with drugs caffeine, gamma-glutamyl glycine, and 3-isobutyl-1-methyl-7H-xanthine.	Caffeine	89-97	phosphodiesterase 9A	Homo sapiens	56-61
30983343-9	2019	The addition of either caffeine or any one of the three amino acids decreased the expression of both MRP2 and P-gp induced by EGCG, and the expression of P-gp induced by ECG or EC also decreased.	Caffeine	23-31	ATP binding cassette subfamily C member 2	Homo sapiens	101-105
31143551-4	2019	However, the sarcoplasmic reticulum Ca2+ content was significantly reduced in the cardiomyocytes of RyR2-PBmice as assessed by measuring caffeine-induced [Ca2+]i transients; the cardiac muscle tissue of RyR2-PBmice displayed significant mitochondrial swelling and focal dissolution of mitochondrial cristae, and the tissue ATP content in the RyR2-PBmice heart was significantly reduced.	Caffeine	137-145	ryanodine receptor 2, cardiac	Mus musculus	100-104
30983343-9	2019	The addition of either caffeine or any one of the three amino acids decreased the expression of both MRP2 and P-gp induced by EGCG, and the expression of P-gp induced by ECG or EC also decreased.	Caffeine	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
30983343-9	2019	The addition of either caffeine or any one of the three amino acids decreased the expression of both MRP2 and P-gp induced by EGCG, and the expression of P-gp induced by ECG or EC also decreased.	Caffeine	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	154-158
31164617-3	2019	The metabolic rates of caffeine, dextromethorphan, midazolam, omeprazole, and Losartan to the CYP-specific metabolites are validated measures of in vivo CYP 1A2, 2D6, 3A4, 2C19, and 2C9 activities, respectively.	Caffeine	23-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	94-97
31091792-0	2019	Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro.	Caffeine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-117
31091792-3	2019	Interestingly, our findings indicate that caffeine markedly reduced reactive oxygen species (ROS) and lipid peroxidation (LPO) levels and enhanced the expression of nuclear factor-2 erythroid-2 (Nrf-2) and hemeoxygenase-1 (HO-1), which act as endogenous antioxidant regulators.	Caffeine	42-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	195-200
31091792-3	2019	Interestingly, our findings indicate that caffeine markedly reduced reactive oxygen species (ROS) and lipid peroxidation (LPO) levels and enhanced the expression of nuclear factor-2 erythroid-2 (Nrf-2) and hemeoxygenase-1 (HO-1), which act as endogenous antioxidant regulators.	Caffeine	42-50	heme oxygenase 1	Mus musculus	206-227
31091792-5	2019	Similarly, caffeine ameliorated Cd-mediated glial activation by reducing the expression of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), and other inflammatory mediators in the cortical and hippocampal regions of the mouse brain.	Caffeine	11-19	glial fibrillary acidic protein	Mus musculus	91-122
31091792-5	2019	Similarly, caffeine ameliorated Cd-mediated glial activation by reducing the expression of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), and other inflammatory mediators in the cortical and hippocampal regions of the mouse brain.	Caffeine	11-19	glial fibrillary acidic protein	Mus musculus	124-128
31091792-5	2019	Similarly, caffeine ameliorated Cd-mediated glial activation by reducing the expression of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), and other inflammatory mediators in the cortical and hippocampal regions of the mouse brain.	Caffeine	11-19	allograft inflammatory factor 1	Mus musculus	131-173
31091792-5	2019	Similarly, caffeine ameliorated Cd-mediated glial activation by reducing the expression of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), and other inflammatory mediators in the cortical and hippocampal regions of the mouse brain.	Caffeine	11-19	allograft inflammatory factor 1	Mus musculus	175-180
31091792-7	2019	Of note, nuclear factor-2 erythroid-2 (Nrf-2) gene silencing and nuclear factor-kappaB (NF-kappaB) inhibition studies revealed that caffeine exerted neuroprotection via regulation of Nrf-2- and NF-kappaB-dependent mechanisms in the HT-22 and BV-2 cell lines, respectively.	Caffeine	132-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-44
31091792-7	2019	Of note, nuclear factor-2 erythroid-2 (Nrf-2) gene silencing and nuclear factor-kappaB (NF-kappaB) inhibition studies revealed that caffeine exerted neuroprotection via regulation of Nrf-2- and NF-kappaB-dependent mechanisms in the HT-22 and BV-2 cell lines, respectively.	Caffeine	132-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	183-188
31164617-3	2019	The metabolic rates of caffeine, dextromethorphan, midazolam, omeprazole, and Losartan to the CYP-specific metabolites are validated measures of in vivo CYP 1A2, 2D6, 3A4, 2C19, and 2C9 activities, respectively.	Caffeine	23-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	153-160
29402402-0	2019	Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation.	Caffeine	35-43	amylase alpha 1A	Homo sapiens	86-108
29402402-5	2019	In this follow-up article, the effects of strategic caffeine administration on the previously reported diurnal profiles of sAA and performance, and the association between sAA and neurobehavioural performance were investigated.	Caffeine	52-60	amylase alpha 1A	Homo sapiens	123-126
29402402-11	2019	The impact of caffeine on the circadian profile of sAA coincided with changes in neurobehavioural performance.	Caffeine	14-22	amylase alpha 1A	Homo sapiens	51-54
29402402-12	2019	Higher sAA levels were associated with improved performance on the psychomotor vigilance test during the first 24 h of wakefulness in the caffeine condition.	Caffeine	138-146	amylase alpha 1A	Homo sapiens	7-10
29402402-15	2019	Results show that the relationship between sAA and reciprocal-transform of mean reaction time on the psychomotor vigilance test persisted in the presence of caffeine, however the association was relatively weaker as compared with the placebo condition.	Caffeine	157-165	amylase alpha 1A	Homo sapiens	43-46
30515653-9	2019	Also, the use of a diet containing 5% and 8% caffeine prevented these alterations (except 5% of dietary caffeine on ADA activity) and can be considered an interesting approach to preventing the impairment of immune and inflammatory responses elicited by hypoxia, principally the inclusion of 8% caffeine.	Caffeine	45-53	adenosine deaminase	Oreochromis niloticus	116-119
30805671-8	2019	Moreover, inhibiting A2AR by antagonist (SCH 58261) performed the same downstream biological effects as caffeine treatment, and autophagy inhibitor (BafilomycinA1) clearly abolished the caffeine-induced Bcl10 degradation and A20 suppression.	Caffeine	186-194	adenosine A2a receptor	Mus musculus	21-25
30805671-8	2019	Moreover, inhibiting A2AR by antagonist (SCH 58261) performed the same downstream biological effects as caffeine treatment, and autophagy inhibitor (BafilomycinA1) clearly abolished the caffeine-induced Bcl10 degradation and A20 suppression.	Caffeine	186-194	B cell leukemia/lymphoma 10	Mus musculus	203-208
30805671-8	2019	Moreover, inhibiting A2AR by antagonist (SCH 58261) performed the same downstream biological effects as caffeine treatment, and autophagy inhibitor (BafilomycinA1) clearly abolished the caffeine-induced Bcl10 degradation and A20 suppression.	Caffeine	186-194	tumor necrosis factor, alpha-induced protein 3	Mus musculus	225-228
30762305-0	2019	Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam.	Caffeine	139-147	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	49-55
30326789-9	2019	However, higher SD1 values were observed after caffeine administration from 60 to 300 s post-exercise recovery (p = 0.01-0.05) but not for the effects of expectancy (p = 0.19-0.94).	Caffeine	47-55	CUP2Q35	Homo sapiens	16-19
30985253-7	2019	The resultant network revealed seven hitherto unannotated proteins, namely, Atg14p, Rim20p, Ret2p, Spt21p, Ylr257wp, Ymr295cp, and Ygr017wp, as potential components of TOR-mediated rapamycin and caffeine signaling in yeast.	Caffeine	195-203	Atg14p	Saccharomyces cerevisiae S288C	76-82
30985253-7	2019	The resultant network revealed seven hitherto unannotated proteins, namely, Atg14p, Rim20p, Ret2p, Spt21p, Ylr257wp, Ymr295cp, and Ygr017wp, as potential components of TOR-mediated rapamycin and caffeine signaling in yeast.	Caffeine	195-203	Rim20p	Saccharomyces cerevisiae S288C	84-90
30985253-7	2019	The resultant network revealed seven hitherto unannotated proteins, namely, Atg14p, Rim20p, Ret2p, Spt21p, Ylr257wp, Ymr295cp, and Ygr017wp, as potential components of TOR-mediated rapamycin and caffeine signaling in yeast.	Caffeine	195-203	coatomer subunit delta	Saccharomyces cerevisiae S288C	92-97
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	Caffeine	36-44	phosphatase and tensin homolog	Homo sapiens	138-170
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	Caffeine	36-44	phosphatase and tensin homolog	Homo sapiens	172-176
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	Caffeine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	194-223
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	Caffeine	36-44	mechanistic target of rapamycin kinase	Homo sapiens	225-229
30875347-9	2019	These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics.	Caffeine	56-64	phosphatase and tensin homolog	Homo sapiens	149-153
30875347-9	2019	These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics.	Caffeine	56-64	AKT serine/threonine kinase 1	Homo sapiens	174-177
30875347-9	2019	These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics.	Caffeine	56-64	mechanistic target of rapamycin kinase	Homo sapiens	178-182
30924039-10	2019	Bivariate analysis showed an association between CDKN2B methylation and pesticide exposure, general characteristics, smoking status, and micronutrients, while changes in CDKN2A methylation were associated with pesticide exposure, sex, educational level, body mass index, smoking status, supplement intake, clinical parameters, and caffeine consumption.	Caffeine	331-339	cyclin dependent kinase inhibitor 2A	Homo sapiens	170-176
31161749-6	2019	The levels of POU5F1, SOX2, and NANOG expression in blastocysts were significantly higher in the delayed activation caffeine group (4 h, 1.25 mM) than in the control group (1 h, 0 mM; p &lt; 0.05).	Caffeine	116-124	POU class 5 homeobox 1	Homo sapiens	14-20
31161749-6	2019	The levels of POU5F1, SOX2, and NANOG expression in blastocysts were significantly higher in the delayed activation caffeine group (4 h, 1.25 mM) than in the control group (1 h, 0 mM; p &lt; 0.05).	Caffeine	116-124	Nanog homeobox	Homo sapiens	32-37
30825513-0	2019	Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats.	Caffeine	0-8	sirtuin 1	Rattus norvegicus	26-31
30825513-0	2019	Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats.	Caffeine	0-8	adenosine A2a receptor	Rattus norvegicus	91-95
30825513-0	2019	Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats.	Caffeine	0-8	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	101-104
30825513-11	2019	Therefore, our results confirmed that caffeine could enhance histone acetylation and expression levels of genes responsible for cholesterol synthesis via inhibiting the A2AR/cAMP/PKA pathway and down-regulating sirtuin1, which continued throughout adulthood and elevated hepatic cholesterol synthesis and hypercholesterolemia in the male offspring rats.	Caffeine	38-46	adenosine A2a receptor	Rattus norvegicus	169-173
30825513-11	2019	Therefore, our results confirmed that caffeine could enhance histone acetylation and expression levels of genes responsible for cholesterol synthesis via inhibiting the A2AR/cAMP/PKA pathway and down-regulating sirtuin1, which continued throughout adulthood and elevated hepatic cholesterol synthesis and hypercholesterolemia in the male offspring rats.	Caffeine	38-46	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	179-182
30825513-11	2019	Therefore, our results confirmed that caffeine could enhance histone acetylation and expression levels of genes responsible for cholesterol synthesis via inhibiting the A2AR/cAMP/PKA pathway and down-regulating sirtuin1, which continued throughout adulthood and elevated hepatic cholesterol synthesis and hypercholesterolemia in the male offspring rats.	Caffeine	38-46	sirtuin 1	Rattus norvegicus	211-219
30746733-10	2019	The topical application of 0.1% caffeine did not induce skin or HF cytotoxicity and stimulated the expression of IGF-1 in the proximal HF ORS.	Caffeine	32-40	insulin like growth factor 1	Homo sapiens	113-118
30689395-8	2019	Caffeine increased exposure during pregnancy was related to reduced activity of caffeine metabolizing enzyme CYP1A2.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
30579884-6	2019	In Experiment 2, acute caffeine administration profoundly decreased tph2 and slc22a3 mRNA expression throughout the DR, with no effects on htr1a or slc6a4 mRNA expression.	Caffeine	23-31	tryptophan hydroxylase 2	Rattus norvegicus	68-72
30579884-6	2019	In Experiment 2, acute caffeine administration profoundly decreased tph2 and slc22a3 mRNA expression throughout the DR, with no effects on htr1a or slc6a4 mRNA expression.	Caffeine	23-31	solute carrier family 22 member 3	Rattus norvegicus	77-84
30579884-7	2019	Chronic caffeine exposure for four weeks during adolescence was sufficient to decrease tph2 mRNA expression in the DR measured 28 h after caffeine withdrawal.	Caffeine	8-16	tryptophan hydroxylase 2	Rattus norvegicus	87-91
30776459-0	2019	Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPalpha-SIRT1 pathway.	Caffeine	9-17	CCAAT enhancer binding protein alpha	Homo sapiens	139-149
30776459-0	2019	Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPalpha-SIRT1 pathway.	Caffeine	9-17	sirtuin 1	Rattus norvegicus	150-155
30677877-4	2019	Three were present in influent at concentrations &gt;1 mug L-1 (caffeine, cocaine and benzoylecgonine).	Caffeine	64-72	immunoglobulin kappa variable 1-16	Homo sapiens	59-62
30887238-1	2019	A physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin).	Caffeine	213-221	interleukin 6	Homo sapiens	107-125
30840612-8	2019	Furthermore, caffeine or DPCPX improved the expression MBP and CNPase proteins after hypoxia stimulation, which resulted in the morphological maturation of OLs.	Caffeine	13-21	myelin basic protein	Homo sapiens	55-58
30682535-9	2019	After caffeine challenge, reduced CBF, Ew and PSw were observed, demonstrating the sensitivity of IDEALS approach.	Caffeine	6-14	CCAAT enhancer binding protein zeta	Homo sapiens	34-37
30689395-8	2019	Caffeine increased exposure during pregnancy was related to reduced activity of caffeine metabolizing enzyme CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
30553055-0	2019	Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.	Caffeine	0-8	interleukin 6	Mus musculus	27-31
30811647-12	2019	We suggest that these results might be, at least in part, associated with the antagonist activity of caffeine on adenosine-A2AR mediated growth-promoting effects on HCC cells.	Caffeine	101-109	adenosine A2a receptor	Homo sapiens	123-127
30838377-2	2019	However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at metabolizing caffeine.	Caffeine	213-221	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-154
30838377-2	2019	However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at metabolizing caffeine.	Caffeine	213-221	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
30553055-2	2019	We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver.	Caffeine	20-28	interleukin 6	Mus musculus	130-134
30553055-7	2019	The possibility that IL-6/STAT3-mediated hepatic autophagosome induction and hepatocytic oxygen consumption are involved in the anti-NAFLD effects of caffeine cannot be excluded, based on the findings presented here.	Caffeine	150-158	interleukin 6	Mus musculus	21-25
30553055-2	2019	We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver.	Caffeine	20-28	signal transducer and activator of transcription 3	Mus musculus	154-159
30553055-7	2019	The possibility that IL-6/STAT3-mediated hepatic autophagosome induction and hepatocytic oxygen consumption are involved in the anti-NAFLD effects of caffeine cannot be excluded, based on the findings presented here.	Caffeine	150-158	signal transducer and activator of transcription 3	Mus musculus	26-31
30553055-8	2019	Our results reveal that caffeine ameliorates NAFLD via crosstalk between muscle IL-6 production and liver STAT3 activation.	Caffeine	24-32	interleukin 6	Mus musculus	80-84
30553055-8	2019	Our results reveal that caffeine ameliorates NAFLD via crosstalk between muscle IL-6 production and liver STAT3 activation.	Caffeine	24-32	signal transducer and activator of transcription 3	Mus musculus	106-111
30553055-3	2019	Interestingly, the expression of IL-6 mRNA was not increased in the liver, but increased substantially in the muscles of caffeine-treated mice.	Caffeine	121-129	interleukin 6	Mus musculus	33-37
30553055-4	2019	Caffeine was found to stimulate IL-6 production in cultured myotubes but not in hepatocytes, adipocytes, or macrophages.	Caffeine	0-8	interleukin 6	Mus musculus	32-36
30553055-5	2019	The inhibition of p38/MAPK abrogated caffeine-induced IL-6 production in muscle cells.	Caffeine	37-45	mitogen-activated protein kinase 14	Mus musculus	18-21
30553055-5	2019	The inhibition of p38/MAPK abrogated caffeine-induced IL-6 production in muscle cells.	Caffeine	37-45	interleukin 6	Mus musculus	54-58
30798915-11	2019	Various compounds that accelerate emergence from anesthesia, thus mitigating problematic effects associated with delayed emergence such as delirium, also activate AMPK (e.g. nicotine, caffeine, forskolin, carbachol).	Caffeine	184-192	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-167
30537591-8	2019	For example, paracetamol, cotinine and caffeine were measured at 1100 mug L-1, 31 mug L-1 and 200 mug L-1, respectively, which is comparable to septic tank effluents.	Caffeine	39-47	immunoglobulin kappa variable 1-16	Homo sapiens	86-105
30773300-3	2019	We measured the changes in blood pressure (BP) and calculation speed upon coffee intake, stratifying with gene polymorphisms, e.g., those in adenosine A2A receptor (ADORA2A) and cytochrome P450 (CYP) 1A2, and daily caffeine consumption (&lt;=90 mg/day and &gt;90 mg/day).	Caffeine	215-223	adenosine A2a receptor	Homo sapiens	165-172
30773300-5	2019	In stratified analysis, a statistical significance within the caffeinated group was observed for the change in systolic BP in the stratum of CYP1A2 polymorphism with daily caffeine consumption &lt;=90 mg/day: change in systolic BP in the CYP1A2 rs762551 CC group (mean +- SD = 11.8 +- 5.9) was higher than that in the AA/CA group (4.1 +- 5.5).	Caffeine	172-180	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	141-147
30468874-4	2019	Therefore, taking advantage of the ability of mammalian protein kinase R (PKR) to switch off most cellular translation processes in response to infection by viruses, we fused a caffeine-inducible dimerization domain to the catalytic domain of PKR.	Caffeine	177-185	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-72
30649305-4	2019	Deletion of 284KKCPK288 destabilises the Prs1/Prs3 complex resulting in a cascade of events, including reduction in PRPP synthetase activity and altered cell wall integrity (CWI) as measured by caffeine sensitivity and Rlm1 expression.	Caffeine	194-202	ribose phosphate diphosphokinase subunit PRS1	Saccharomyces cerevisiae S288C	41-45
30649305-4	2019	Deletion of 284KKCPK288 destabilises the Prs1/Prs3 complex resulting in a cascade of events, including reduction in PRPP synthetase activity and altered cell wall integrity (CWI) as measured by caffeine sensitivity and Rlm1 expression.	Caffeine	194-202	ribose phosphate diphosphokinase subunit PRS3	Saccharomyces cerevisiae S288C	46-50
30468874-4	2019	Therefore, taking advantage of the ability of mammalian protein kinase R (PKR) to switch off most cellular translation processes in response to infection by viruses, we fused a caffeine-inducible dimerization domain to the catalytic domain of PKR.	Caffeine	177-185	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
30911576-7	2019	Profiles from PARK2 patients showed significantly higher levels of fatty acid (FA) metabolites and oxidized lipids, and significantly lower levels of antioxidant, caffeine, and benzoate-related metabolites.	Caffeine	163-171	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	14-19
30468874-4	2019	Therefore, taking advantage of the ability of mammalian protein kinase R (PKR) to switch off most cellular translation processes in response to infection by viruses, we fused a caffeine-inducible dimerization domain to the catalytic domain of PKR.	Caffeine	177-185	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	243-246
30468874-5	2019	Addition of caffeine to this construct results in homodimerization and activation of PKR, effectively rewiring rapid global translational downregulation to the addition of the stimulus in a dose-dependent manner.	Caffeine	12-20	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	85-88
30307561-6	2019	Intranasal administration of the adenosine receptor antagonist caffeine substantially enhanced the frequency and number of parenchymal CD4+ T cells as well as both CD69 expression and IFNgamma production.	Caffeine	63-71	CD4 antigen	Mus musculus	135-138
30307561-6	2019	Intranasal administration of the adenosine receptor antagonist caffeine substantially enhanced the frequency and number of parenchymal CD4+ T cells as well as both CD69 expression and IFNgamma production.	Caffeine	63-71	CD69 antigen	Mus musculus	164-168
30528684-0	2019	Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.	Caffeine	167-175	insulin-like growth factor 1	Rattus norvegicus	57-85
30528684-0	2019	Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.	Caffeine	167-175	insulin-like growth factor 1	Rattus norvegicus	90-94
30860473-1	2019	Caffeine is one of the most extensively consumed stimulants in the world and has been suggested to induce wakefulness by antagonizing the function of the adenosine A2A receptor.	Caffeine	0-8	adenosine A2a receptor	Rattus norvegicus	154-176
30860473-14	2019	Chronic consumption of caffeine caused up-regulation in Grin2a that subunit of NMDA receptor.	Caffeine	23-31	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	56-62
30170228-12	2019	Functionally, the ID-associated mutations showed a markedly enhanced response of RyR2 to activation by caffeine.	Caffeine	103-111	ryanodine receptor 2	Homo sapiens	81-85
31565368-6	2019	In this study, a caffeine concentration of 0.25 mg mL-1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL-1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL-1 concentration on the fetal side is achieved after 5 h.	Caffeine	17-25	L1 cell adhesion molecule	Mus musculus	51-55
31565368-6	2019	In this study, a caffeine concentration of 0.25 mg mL-1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL-1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL-1 concentration on the fetal side is achieved after 5 h.	Caffeine	17-25	L1 cell adhesion molecule	Mus musculus	203-207
31565368-6	2019	In this study, a caffeine concentration of 0.25 mg mL-1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL-1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL-1 concentration on the fetal side is achieved after 5 h.	Caffeine	17-25	L1 cell adhesion molecule	Mus musculus	203-207
31565368-6	2019	In this study, a caffeine concentration of 0.25 mg mL-1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL-1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL-1 concentration on the fetal side is achieved after 5 h.	Caffeine	167-175	L1 cell adhesion molecule	Mus musculus	203-207
31565368-6	2019	In this study, a caffeine concentration of 0.25 mg mL-1 is introduced into the maternal channel, and the resulting changes are observed over a span of 7.5 h. A steady caffeine concentration of 0.1513 mg mL-1 is reached on the maternal side after 6.5 h, and a 0.0033 mg mL-1 concentration on the fetal side is achieved after 5 h.	Caffeine	167-175	L1 cell adhesion molecule	Mus musculus	203-207
30317168-6	2019	Of the compounds analysed, tris(2-butoxyethyl) phosphate, sucralose, caffeine, and benzophenone showed high abundancy with maximum concentrations in the mug L-1 range.	Caffeine	69-77	immunoglobulin kappa variable 1-16	Homo sapiens	157-160
30445356-3	2019	We described the development and validation of three sensitive and specific LC-MS/MS assays for the determination of P-gp and major human CYP isoenzyme activities following oral administration of a drug cocktail of subtherapeutic doses (lower than 10 times) of caffeine (CAF), omeprazole (OME), losartan (LOS), midazolam (MDZ), metoprolol (METO) and fexofenadine (FEX) in healthy volunteers.	Caffeine	261-269	phosphoglycolate phosphatase	Homo sapiens	117-121
30377735-6	2019	Adding the anti-sFRP1 antibody (0.5 microg/ml) and inhibiting sFRP1 secretion by caffeine (5 mM) both relieved Dox-induced cardiotoxicity through activating Wnt/beta-catenin signaling, whereas increasing the secretion of sFRP1 by heparin (100 microg/ml) had the opposite effect.	Caffeine	81-89	secreted frizzled-related protein 1	Rattus norvegicus	62-67
30377735-6	2019	Adding the anti-sFRP1 antibody (0.5 microg/ml) and inhibiting sFRP1 secretion by caffeine (5 mM) both relieved Dox-induced cardiotoxicity through activating Wnt/beta-catenin signaling, whereas increasing the secretion of sFRP1 by heparin (100 microg/ml) had the opposite effect.	Caffeine	81-89	secreted frizzled-related protein 1	Rattus norvegicus	62-67
29532291-0	2019	The effect of CYP1A2 genotype on the ergogenic properties of caffeine during resistance exercise: a randomized, double-blind, placebo-controlled, crossover study.	Caffeine	61-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
29532291-1	2019	AIM: The purpose of this study was to examine the effect of CYP1A2 -163C&gt;A polymorphism on the ergogenic effects of caffeine supplementation during a resistance exercise (RE) session.	Caffeine	119-127	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
29532291-10	2019	Further studies are needed to replicate the potential role of the CYP1A2 -163C&gt;A polymorphism on the ergogenic effects of CAF in other modes of exercise and in other populations.	Caffeine	125-128	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
29797183-4	2019	A1-D1 receptor heteromers play a significant control of the motoneuron excitability, represent main targets for the excitatory effects of caffeine in the spinal cord and can constitute new targets for the pharmacological therapy after spinal cord injury, motor aging-associated disorders and restless legs syndrome.	Caffeine	138-146	dopamine receptor D1	Mus musculus	3-14
29320928-0	2019	Interaction of caffeine and sulfadiazine with lysozyme adsorbed at colloidal metal nanoparticle interface: influence on drug transport ability and antibacterial activity.	Caffeine	15-23	lysozyme	Homo sapiens	46-54
28967799-6	2019	None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine.	Caffeine	170-178	C-reactive protein	Homo sapiens	144-147
30387917-0	2019	Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis.	Caffeine	93-101	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	18-24
30387917-1	2019	The caffeine metabolic ratio is an established marker for cytochrome P450 (CYP) 1A2 activity.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-83
30423516-7	2019	Administration of caffeine to rats resulted in a decreased SWD number at 30 and 60 min as determined by EEG recording after baseline (p < .05), and a significant increase in NFkB and IL-6 levels in the thalamic tissue (p < .05).	Caffeine	18-26	nuclear factor kappa B subunit 1	Rattus norvegicus	174-178
30423516-7	2019	Administration of caffeine to rats resulted in a decreased SWD number at 30 and 60 min as determined by EEG recording after baseline (p < .05), and a significant increase in NFkB and IL-6 levels in the thalamic tissue (p < .05).	Caffeine	18-26	interleukin 6	Rattus norvegicus	183-187
30686981-12	2018	Caffeine prevented T2D-induced alterations of GFAP, vimentin and SNAP25, and improved memory deficits.	Caffeine	0-8	glial fibrillary acidic protein	Rattus norvegicus	46-50
30686981-12	2018	Caffeine prevented T2D-induced alterations of GFAP, vimentin and SNAP25, and improved memory deficits.	Caffeine	0-8	vimentin	Rattus norvegicus	52-60
30686981-12	2018	Caffeine prevented T2D-induced alterations of GFAP, vimentin and SNAP25, and improved memory deficits.	Caffeine	0-8	synaptosome associated protein 25	Rattus norvegicus	65-71
30977988-0	2019	Caffeine Accelerates Cystic Kidney Disease in a Pkd1-Deficient Mouse Model.	Caffeine	0-8	polycystin 1, transient receptor potential channel interacting	Mus musculus	48-52
30977988-4	2019	METHODS: Caffeine was administered to male cystic (CyCaf) and noncystic (NCCaf) mice (Pkd1cond/cond) from conception and at the postweaning period through 12 weeks of life (3 mg/d), while control animals consumed water (CyCtrl and NCCtrl).	Caffeine	9-17	polycystin 1, transient receptor potential channel interacting	Mus musculus	86-90
30543170-5	2019	RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors.	Caffeine	78-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
30543170-5	2019	RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors.	Caffeine	78-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
28967799-7	2019	Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies.	Caffeine	114-122	interleukin 6	Homo sapiens	0-18
28967799-8	2019	Caffeine increased IL-10 levels in two of three trials.	Caffeine	0-8	interleukin 10	Homo sapiens	19-24
29730765-8	2019	This novel molecular mechanism was studied further at the cellular level, where faster release kinetics of caffeine-induced Ca2+ release were measured in SH-SY5Y neuroblastoma cells overexpressing calsenilin.	Caffeine	107-115	potassium voltage-gated channel interacting protein 3	Homo sapiens	197-207
31168028-8	2019	The antioxidant N-acetylcysteine reduced the expression of phosphorylated ATM and H2AX, and the ATM inhibitor, caffeine, inhibited p53 activation.	Caffeine	111-119	ATM serine/threonine kinase	Homo sapiens	96-99
31168028-8	2019	The antioxidant N-acetylcysteine reduced the expression of phosphorylated ATM and H2AX, and the ATM inhibitor, caffeine, inhibited p53 activation.	Caffeine	111-119	tumor protein p53	Homo sapiens	131-134
30454882-0	2019	High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.	Caffeine	124-132	slit guidance ligand 3	Homo sapiens	28-33
30483783-10	2019	The expression of MICB induced by MG132 was inhibited by KU-55933 [ataxia telangiectasia mutated (ATM) kinase inhibitor], wortmannin (phosphoinositide 3 kinase inhibitor) and caffeine (ATM/ATM-Rad3-related inhibitor).	Caffeine	175-183	MHC class I polypeptide-related sequence B	Homo sapiens	18-22
30362123-2	2019	XP-V cellular phenotypes may be aggravated if proteins of DNA damage response (DDR) pathway are blocked, as widely demonstrated by experiments with UVC light and caffeine.	Caffeine	162-170	DNA polymerase eta	Homo sapiens	0-4
30242840-5	2019	Drugs (caffeine, theophylline) and hormones (vasopressin, aldosterone) known to exacerbate cysts elicit NHA2 expression.	Caffeine	7-15	solute carrier family 9 member B2	Homo sapiens	104-108
30242840-13	2019	We showed that NHA2 is a target of Ca2+ /NFAT signalling and is transcriptionally induced by methylxanthine drugs such as caffeine and theophylline, which are contraindicated in ADPKD patients.	Caffeine	122-130	solute carrier family 9 member B2	Homo sapiens	15-19
30326239-3	2019	In particular, adenosine A1 receptors (A1R) are enriched in CA2, and based on the prominent synaptic potentiation induced by A1R antagonists (e.g., caffeine) in this area, it has been proposed that CA2 is under the strong tonic control of A1R activation.	Caffeine	148-156	carbonic anhydrase 2	Homo sapiens	60-63
30326239-3	2019	In particular, adenosine A1 receptors (A1R) are enriched in CA2, and based on the prominent synaptic potentiation induced by A1R antagonists (e.g., caffeine) in this area, it has been proposed that CA2 is under the strong tonic control of A1R activation.	Caffeine	148-156	carbonic anhydrase 2	Homo sapiens	198-201
30326239-5	2019	Here, using the recording of field potentials evoked simultaneously in CA2 and CA1 by Schaffer collateral stimulation, we confirm that the application of A1R antagonists, caffeine and DPCPX has a stronger effect on synaptic responses in CA2 than in those evoked in CA1.	Caffeine	171-179	carbonic anhydrase 2	Homo sapiens	71-74
30326239-5	2019	Here, using the recording of field potentials evoked simultaneously in CA2 and CA1 by Schaffer collateral stimulation, we confirm that the application of A1R antagonists, caffeine and DPCPX has a stronger effect on synaptic responses in CA2 than in those evoked in CA1.	Caffeine	171-179	carbonic anhydrase 1	Homo sapiens	79-82
30326239-5	2019	Here, using the recording of field potentials evoked simultaneously in CA2 and CA1 by Schaffer collateral stimulation, we confirm that the application of A1R antagonists, caffeine and DPCPX has a stronger effect on synaptic responses in CA2 than in those evoked in CA1.	Caffeine	171-179	carbonic anhydrase 2	Homo sapiens	237-240
30326239-5	2019	Here, using the recording of field potentials evoked simultaneously in CA2 and CA1 by Schaffer collateral stimulation, we confirm that the application of A1R antagonists, caffeine and DPCPX has a stronger effect on synaptic responses in CA2 than in those evoked in CA1.	Caffeine	171-179	carbonic anhydrase 1	Homo sapiens	265-268
30326239-7	2019	We found that caffeine-induced potentiation in CA2 was restricted to Schaffer collateral synapses, but not to those formed by temporoammonic inputs.	Caffeine	14-22	carbonic anhydrase 2	Homo sapiens	47-50
30362831-10	2019	Coffee and caffeine inhibited COX-2 expression in the colon.	Caffeine	11-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	30-35
30454882-0	2019	High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.	Caffeine	124-132	pleckstrin homology domain containing A5	Homo sapiens	35-42
30454882-0	2019	High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.	Caffeine	124-132	protein phosphatase 2 regulatory subunit Bgamma	Homo sapiens	47-54
30454882-0	2019	High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.	Caffeine	124-132	insulin	Homo sapiens	74-81
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	11-19	insulin	Homo sapiens	59-66
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	11-19	insulin	Homo sapiens	175-182
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	131-139	insulin	Homo sapiens	59-66
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	131-139	insulin	Homo sapiens	175-182
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	131-139	insulin	Homo sapiens	59-66
30454882-9	2019	Coffee and caffeine intake and GRS had an interaction with insulin resistance: In subjects with high coffee (&gt;=10 cups/week) or caffeine intake (&gt;=220 mg caffeine/day), insulin resistance was significantly elevated in the High-GRS group, but not in the Low-GRS.	Caffeine	131-139	insulin	Homo sapiens	175-182
30454882-12	2019	CONCLUSIONS: Subjects with High-GRS may be susceptible to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day.	Caffeine	179-187	insulin	Homo sapiens	68-75
30204465-0	2018	Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway.	Caffeine	9-17	cAMP responsive element binding protein 1	Rattus norvegicus	83-87
30204465-0	2018	Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway.	Caffeine	9-17	brain-derived neurotrophic factor	Rattus norvegicus	88-92
30273601-0	2018	Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure.	Caffeine	177-185	insulin-like growth factor 1	Rattus norvegicus	43-71
30997021-0	2019	Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-kappaB at ED 20.	Caffeine	12-20	caspase 3	Rattus norvegicus	87-96
30997021-0	2019	Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-kappaB at ED 20.	Caffeine	12-20	BCL2 associated X, apoptosis regulator	Rattus norvegicus	97-100
30509990-8	2018	A similar profile of greater PP2A methylation and cytoprotection was found in SH-SY5Y cells cotreated with EHT and caffeine, but not with each compound alone.	Caffeine	115-123	protein phosphatase 2 phosphatase activator	Homo sapiens	29-33
30997021-0	2019	Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-kappaB at ED 20.	Caffeine	12-20	BCL2, apoptosis regulator	Rattus norvegicus	101-106
30997021-0	2019	Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-kappaB at ED 20.	Caffeine	12-20	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	107-111
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	insulin-like growth factor 2	Rattus norvegicus	90-96
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	vascular endothelial growth factor A	Rattus norvegicus	98-102
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	tumor necrosis factor	Rattus norvegicus	114-123
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	interleukin 1 beta	Rattus norvegicus	125-133
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	interleukin 6	Rattus norvegicus	135-139
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	mast cell protease 1-like 1	Rattus norvegicus	152-157
30997021-7	2019	Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20.	Caffeine	14-22	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	214-225
30268908-0	2018	Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter.	Caffeine	60-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
30268908-7	2018	Constriction of intact MCA of rat by either 50 mM ethanol or 10 muM caffeine was ablated in the presence of a selective TRPV1 pharmacological blocker.	Caffeine	68-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
30268908-8	2018	TRPV1 pharmacological block, but not block of TRPA1, PKG, or BK channels, removed caffeine-induced protection against ethanol-evoked rat MCA constriction, whether evaluated in arteries with intact endothelium or in SNP-supplemented, de-endothelialized arteries.	Caffeine	82-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
30268908-9	2018	In mouse arteries, caffeine-induced protection against ethanol-induced MCA constriction was significantly amplified, resulting in actual vasodilation, upon pharmacological block of TRPV1, and in TRPV1 knock-out arteries.	Caffeine	19-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	181-186
30268908-9	2018	In mouse arteries, caffeine-induced protection against ethanol-induced MCA constriction was significantly amplified, resulting in actual vasodilation, upon pharmacological block of TRPV1, and in TRPV1 knock-out arteries.	Caffeine	19-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	195-200
30268908-10	2018	Despite some species-specific differences, our study unequivocally demonstrates the presence of functional, extra-endothelial TRPV1 that participates in both endothelium-independent MCA constriction by separate exposure to ethanol or caffeine and caffeine-induced protection against ethanol-evoked MCA constriction.	Caffeine	234-242	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	126-131
30268908-10	2018	Despite some species-specific differences, our study unequivocally demonstrates the presence of functional, extra-endothelial TRPV1 that participates in both endothelium-independent MCA constriction by separate exposure to ethanol or caffeine and caffeine-induced protection against ethanol-evoked MCA constriction.	Caffeine	247-255	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	126-131
30273601-6	2018	In vitro experiments found that corticosterone instead of caffeine restrains mineralized nodule formation and osteoblast differentiation by inhibiting IGF1 expression.	Caffeine	58-66	insulin-like growth factor 1	Rattus norvegicus	151-155
30273601-8	2018	In conclusion, glucocorticoid instead of caffeine inhibits bone IGF1 expression via glucocorticoid receptor and CCAAT and enhancer binding protein alpha and mediates the PCE-induced bone dysplasia and bone mass reduction in offspring fetal rats, which may contribute to osteoporosis susceptibility in adulthood.	Caffeine	41-49	insulin-like growth factor 1	Rattus norvegicus	64-68
30596206-1	2018	Recent studies on interactions between striatal adenosine and dopamine and one of its main targets, the adenosine A2A receptor-dopamine D2 receptor (A2AR-D2R) heteromer, have provided a better understanding of the mechanisms involved in the psychostimulant effects of caffeine and have brought forward new data on the mechanisms of operation of classical orthosteric ligands within G protein-coupled receptor heteromers.	Caffeine	268-276	adenosine A2a receptor	Homo sapiens	149-153
30497637-3	2018	To estimate caffeine consumption in the previous 24 hours, the 24-Hour Caffeine Intake Recall (CIR-24) was modeled after the Automated Self-Administered 24-Hour Dietary Assessment Tool, using a brand-specific database of caffeine-containing foods, beverages, and supplements.	Caffeine	71-79	corepressor interacting with RBPJ, CIR1	Homo sapiens	95-98
30497637-8	2018	RESULTS: The CIR-24 was significantly positively associated with all caffeine biomarkers (rp=0.28 to 0.52, kappa=0.39 to 0.59), and the CBQ was significantly positively associated with all but one biomarker (rp=0.21 to 0.40, kappa=0.32 to 0.45).	Caffeine	69-77	corepressor interacting with RBPJ, CIR1	Homo sapiens	13-16
30497637-9	2018	The CIR-24 yielded a higher mean intake of caffeine than the CBQ.	Caffeine	43-51	corepressor interacting with RBPJ, CIR1	Homo sapiens	4-7
30497637-13	2018	The results suggest that the CIR-24 is a promising tool for evaluating caffeine intake among this population.	Caffeine	71-79	corepressor interacting with RBPJ, CIR1	Homo sapiens	29-32
30372876-7	2018	HIIT caused an increase in the ADA and AChE activity in lymphocytes and this effect was more pronounced in rats trained and supplemented with caffeine.	Caffeine	142-150	acetylcholinesterase	Rattus norvegicus	39-43
30372876-8	2018	The level of IL-6 was increased while the level of IL-10 was decreased in trained animals (HIIT) and caffeine was capable of preventing this exercise effect.	Caffeine	101-109	interleukin 6	Rattus norvegicus	13-17
30564082-2	2018	To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test.	Caffeine	168-176	N-acetyltransferase 2	Homo sapiens	144-148
30193632-10	2018	The detection limit was 100 ng L-1, which is less than the caffeine content reported in many rivers.	Caffeine	59-67	immunoglobulin kappa variable 1-16	Homo sapiens	31-34
30389846-3	2018	Caffeine sensitizes RyR to Ca2+ and promotes ER Ca2+ release at basal cytosolic Ca2+ levels.	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	20-23
30389846-10	2018	Expression of RyR3 sensitizes the responses to caffeine with effects both in the ER (increase in Ca2+ release) and in the cytosol (increase in Ca2+ peak) at low caffeine concentrations (0.3-1 mM) that have no effects in control cells.	Caffeine	47-55	ryanodine receptor 3	Homo sapiens	14-18
29282363-3	2018	This systematic review and meta-analysis assessed the effects of genetic polymorphisms on CYP1A2 activity, as measured by caffeine metabolism, in a total of 3570 individual subjects.	Caffeine	122-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	90-96
30389846-10	2018	Expression of RyR3 sensitizes the responses to caffeine with effects both in the ER (increase in Ca2+ release) and in the cytosol (increase in Ca2+ peak) at low caffeine concentrations (0.3-1 mM) that have no effects in control cells.	Caffeine	161-169	ryanodine receptor 3	Homo sapiens	14-18
30555576-13	2018	Using a combination of RNAi and chemical treatment, we demonstrate that caffeine activates autophagy through a series of sequential events, starting from the inhibition of its primary cellular target adenosine A2a receptor (A2AR) to an increase in the protein level of Sirtuin 3 (SIRT3) and to the activation of 5" adenosine monophosphate-activated protein kinase (AMPK).	Caffeine	72-80	adenosine A2a receptor	Mus musculus	200-222
30555576-13	2018	Using a combination of RNAi and chemical treatment, we demonstrate that caffeine activates autophagy through a series of sequential events, starting from the inhibition of its primary cellular target adenosine A2a receptor (A2AR) to an increase in the protein level of Sirtuin 3 (SIRT3) and to the activation of 5" adenosine monophosphate-activated protein kinase (AMPK).	Caffeine	72-80	adenosine A2a receptor	Mus musculus	224-228
30555576-13	2018	Using a combination of RNAi and chemical treatment, we demonstrate that caffeine activates autophagy through a series of sequential events, starting from the inhibition of its primary cellular target adenosine A2a receptor (A2AR) to an increase in the protein level of Sirtuin 3 (SIRT3) and to the activation of 5" adenosine monophosphate-activated protein kinase (AMPK).	Caffeine	72-80	sirtuin 3	Mus musculus	269-278
30555576-13	2018	Using a combination of RNAi and chemical treatment, we demonstrate that caffeine activates autophagy through a series of sequential events, starting from the inhibition of its primary cellular target adenosine A2a receptor (A2AR) to an increase in the protein level of Sirtuin 3 (SIRT3) and to the activation of 5" adenosine monophosphate-activated protein kinase (AMPK).	Caffeine	72-80	sirtuin 3	Mus musculus	280-285
30555576-14	2018	Oral administration of caffeine increased the protein level of SIRT3, induced autophagy, and reduced senescence and tissue damage in UV-irradiated mouse skin.	Caffeine	23-31	sirtuin 3	Mus musculus	63-68
30555576-16	2018	Conclusion: The results reveal that caffeine protects skin from oxidative stress-induced senescence through activating the A2AR/SIRT3/AMPK-mediated autophagy.	Caffeine	36-44	adenosine A2a receptor	Mus musculus	123-127
30555576-16	2018	Conclusion: The results reveal that caffeine protects skin from oxidative stress-induced senescence through activating the A2AR/SIRT3/AMPK-mediated autophagy.	Caffeine	36-44	sirtuin 3	Mus musculus	128-133
29659178-0	2018	A Prospective Randomized, Double-Blind, Two-Period Crossover Pharmacokinetic Trial Comparing Green Coffee Bean Extract-A Botanically Sourced Caffeine-With a Synthetic USP Control.	Caffeine	141-149	brain expressed associated with NEDD4 1	Homo sapiens	106-110
30459562-4	2018	Pre-incubation of slices with ryanodine (1 muM, 1 h) or caffeine (1 mM, 30 min) to promote RyR-mediated Ca2+ release facilitated LTD induction by low frequency stimulation (LFS), but did not affect the amplitude of synaptic transmission, the profiles of field excitatory postsynaptic potentials (fEPSP) or the paired-pulse (PP) responses.	Caffeine	56-64	ryanodine receptor 2	Rattus norvegicus	91-94
30459562-4	2018	Pre-incubation of slices with ryanodine (1 muM, 1 h) or caffeine (1 mM, 30 min) to promote RyR-mediated Ca2+ release facilitated LTD induction by low frequency stimulation (LFS), but did not affect the amplitude of synaptic transmission, the profiles of field excitatory postsynaptic potentials (fEPSP) or the paired-pulse (PP) responses.	Caffeine	56-64	carbonic anhydrase 2	Rattus norvegicus	104-107
29659178-13	2018	It would appear that CGA compounds from the natural caffeine extract are bioavailable, and 3-CGA may be the compound most absorbed.	Caffeine	52-60	chromogranin A	Homo sapiens	21-24
29557061-9	2018	Caffeine normalized BDNF in males and truncated TrkB receptor at both sexes.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	20-24
29557061-11	2018	Besides, our data revealed that caffeine intake since childhood attenuated behavioral alterations in the ADHD model associated with changes in BDNF and TrkB receptors in the hippocampus.	Caffeine	32-40	brain-derived neurotrophic factor	Rattus norvegicus	143-147
29557061-11	2018	Besides, our data revealed that caffeine intake since childhood attenuated behavioral alterations in the ADHD model associated with changes in BDNF and TrkB receptors in the hippocampus.	Caffeine	32-40	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	152-156
30348178-7	2018	Analysis also indicated a significant difference in CMJ performance across conditions, with caffeine eliciting a greater response (F[1, 11] = 10.12, P = 0.009, partial eta2 = 0.479).	Caffeine	92-100	DNA polymerase iota	Homo sapiens	168-172
30118793-6	2018	CSC also increased toxicity of caffeine, which is handled by two PDR transporters, Pdr5 and Snq2.	Caffeine	31-39	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	83-87
30118793-6	2018	CSC also increased toxicity of caffeine, which is handled by two PDR transporters, Pdr5 and Snq2.	Caffeine	31-39	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	92-96
30356105-5	2018	The PM phenotype of CYP1A2*1 F for slow metabolism of caffeine and carcinogens was significantly higher in Indians (SDS 42%, GIH [Gujarati] 51%, SAS [Pakistani] 45%) compared to Europeans 29% (pgenotype = 5.3E-05).	Caffeine	54-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
30249030-8	2018	Simvastatin, theophylline, caffeine, and sildenafil, like KMUP-1, also enhanced HSL immunoreactivity.	Caffeine	27-35	lipase, hormone sensitive	Mus musculus	80-83
30356673-8	2018	Potentially proarrhythmic spontaneous transient-inward currents were significantly more frequent in HFrEF and HFrEF-cAF compared to Ctl, likely resulting from increased sarcoplasmic reticulum (SR) Ca2+ load (integrated caffeine-induced current) in HFrEF and increased ryanodine-receptor (RyR2) single-channel open probability in HFrEF and HFrEF-cAF.	Caffeine	116-119	ryanodine receptor 2	Homo sapiens	288-292
29762875-5	2018	In smokers with elevated CYP1A2 activity demonstrated by high caffeine clearance (a marker of CYP1A2 induction), the AUC0-inf was 32.3% lower, whereas the Cmax was 14.4% higher than that in nonsmokers.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
29762875-5	2018	In smokers with elevated CYP1A2 activity demonstrated by high caffeine clearance (a marker of CYP1A2 induction), the AUC0-inf was 32.3% lower, whereas the Cmax was 14.4% higher than that in nonsmokers.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	94-100
29870745-4	2018	An adapted assay protocol was used to demonstrate the effects of carbaryl, dichlorvos and caffeine as model AChE inhibitors towards zfAChE.	Caffeine	90-98	acetylcholinesterase	Danio rerio	108-112
29870745-4	2018	An adapted assay protocol was used to demonstrate the effects of carbaryl, dichlorvos and caffeine as model AChE inhibitors towards zfAChE.	Caffeine	90-98	acetylcholinesterase	Danio rerio	132-138
30257492-6	2018	Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption.	Caffeine	148-156	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	64-70
30257492-6	2018	Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption.	Caffeine	148-156	aryl hydrocarbon receptor	Homo sapiens	76-101
30257492-6	2018	Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption.	Caffeine	148-156	aryl hydrocarbon receptor	Homo sapiens	103-106
30308973-2	2018	Matcha, which is essentially theanine-rich powdered green tea, is abundant in caffeine.	Caffeine	78-86	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	58-61
30144900-7	2018	CYP1A2 activity, derived as the log-transformed molar ratios of caffeine and its metabolites, was statistically analysed for changes in metabolic phenotype.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
29958987-0	2018	Prenatal caffeine ingestion induces long-term alterations in scavenger receptor class B type I expression and glucocorticoid synthesis in adult male offspring rat adrenals.	Caffeine	9-17	scavenger receptor class B, member 1	Rattus norvegicus	61-94
29966748-0	2018	Prenatal caffeine exprosure increases adult female offspring rat"s susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation.	Caffeine	9-17	insulin-like growth factor 1	Rattus norvegicus	144-149
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Caffeine	32-40	insulin-like growth factor 1	Rattus norvegicus	86-91
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Caffeine	32-40	collagen type II alpha 1 chain	Rattus norvegicus	123-129
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Caffeine	32-40	insulin-like growth factor 1	Rattus norvegicus	205-210
30248915-4	2018	CYP1A2 and ADORA2A are two of the genes which are thought to have the largest impact on the ergogenicity of caffeine.	Caffeine	108-116	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
30248915-4	2018	CYP1A2 and ADORA2A are two of the genes which are thought to have the largest impact on the ergogenicity of caffeine.	Caffeine	108-116	adenosine A2a receptor	Homo sapiens	11-18
30248915-5	2018	CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
30248915-5	2018	CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.	Caffeine	101-109	adenosine A2a receptor	Homo sapiens	74-81
30248915-6	2018	The effects of CYP1A2 and ADORA2A genes on responses to caffeine will be discussed in detail and an overview of the current literature will be presented.	Caffeine	56-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-21
30248915-6	2018	The effects of CYP1A2 and ADORA2A genes on responses to caffeine will be discussed in detail and an overview of the current literature will be presented.	Caffeine	56-64	adenosine A2a receptor	Homo sapiens	26-33
28992765-0	2018	Phenotyping of CYP 4501A2 Activity by Total Overnight Salivary Caffeine Assessment (TOSCA) in Patients on Warfarin Treatment: A Cross-Sectional Study.	Caffeine	63-71	peptidylprolyl isomerase G	Homo sapiens	15-18
30294600-1	2018	The aim of this study was to verify the effects of caffeine on anaerobic capacity estimated by the sum of the estimated glycolytic [E[La]] and phosphagen [EPCr] metabolism based on blood lactate and excess post-oxygen consumption responses (AC[La-]+EPOCfast).	Caffeine	51-59	protein C receptor	Homo sapiens	155-159
30177851-6	2018	MYB inhibition is suppressed by caffeine, suggesting that MYB is inhibited indirectly via DNA-damage signalling.	Caffeine	32-40	MYB proto-oncogene, transcription factor	Homo sapiens	0-3
30177851-6	2018	MYB inhibition is suppressed by caffeine, suggesting that MYB is inhibited indirectly via DNA-damage signalling.	Caffeine	32-40	MYB proto-oncogene, transcription factor	Homo sapiens	58-61
30036502-9	2018	Moreover, DTBHA antagonized thapsigargin-stimulated Ca2+ leak in cardiac SR and reduced caffeine-induced, RyR2-activated Ca2+ release in RyR2 expressing HEK293 cells.	Caffeine	88-96	ryanodine receptor 2	Homo sapiens	106-110
30036502-9	2018	Moreover, DTBHA antagonized thapsigargin-stimulated Ca2+ leak in cardiac SR and reduced caffeine-induced, RyR2-activated Ca2+ release in RyR2 expressing HEK293 cells.	Caffeine	88-96	ryanodine receptor 2	Homo sapiens	137-141
28992765-7	2018	The probes for testing CYP1A2 are phenacetin and caffeine while for CYP2C9 tolbutamide.	Caffeine	49-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	23-29
29249184-9	2018	Caffeine treatment significantly decreased the elevated serum ALT, AST, and bilirubin and increased the reduced albumin level.	Caffeine	0-8	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	67-70
29249184-10	2018	Interestingly, the hepatic mRNA expression of Fatty acid synthase and acetyl CoA carboxylase was decreased by caffeine, while the protein expression of hepatic carnitine palmitoyltransferase 1 and proliferation-activated receptor alpha was increased.	Caffeine	110-118	fatty acid synthase	Rattus norvegicus	46-65
29660819-0	2018	Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells.	Caffeine	90-98	cellular communication network factor 2	Homo sapiens	12-16
29660819-5	2018	Caffeine treatment prevented RSV-mediated increase in CTGF mRNA.	Caffeine	0-8	cellular communication network factor 2	Homo sapiens	54-58
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Caffeine	136-144	PLAG1 like zinc finger 1	Homo sapiens	19-23
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Caffeine	136-144	interleukin 11	Homo sapiens	25-30
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Caffeine	136-144	tumor protein p53	Homo sapiens	32-35
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Caffeine	136-144	suppressor of cytokine signaling 3	Homo sapiens	41-75
29923368-7	2018	This phenomenon was blocked in the presence of N-acetyl-cysteine (free-radical scavenger) or caffeine (ATM blocker), as well as in lectin-like oxidized LDL receptor-1 (LOX-1) knockout mice.	Caffeine	93-101	ATM serine/threonine kinase	Homo sapiens	103-106
29883670-7	2018	In concert with two prior studies, these results are suggestive of behavioral evidence for a biphasic effect of adenosine A2A receptor antagonists (caffeine and SCH 58261) that is modulated by tacrine, and a model of this effect is proposed.	Caffeine	148-156	adenosine A2a receptor	Rattus norvegicus	112-134
29913337-8	2018	Under the optimal conditions, an enrichment factor of 11, a limit of detection of 0.05 mug mL-1 and a limit of quantification of 0.16 mug mL-1 were obtained for caffeine.	Caffeine	161-169	L1 cell adhesion molecule	Mus musculus	91-95
29913337-8	2018	Under the optimal conditions, an enrichment factor of 11, a limit of detection of 0.05 mug mL-1 and a limit of quantification of 0.16 mug mL-1 were obtained for caffeine.	Caffeine	161-169	L1 cell adhesion molecule	Mus musculus	138-142
29968042-1	2018	In this study, the formation of caffeine/dapsone (CAF/DAP) cocrystals by scalable production methods, such as liquid-assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed cocrystal powder for pulmonary delivery.	Caffeine	32-40	lysine acetyltransferase 2B	Homo sapiens	50-57
29907324-10	2018	Chondrocyte cultures of the group treated with 50 mg/kg caffeine showed reduced collagen synthesis and Sox-9 expression.	Caffeine	56-64	SRY-box transcription factor 9	Rattus norvegicus	103-108
29907324-11	2018	The caffeine dose of 100 mg/kg also reduced collagen and Sox-9 and alkaline phosphatase expression.	Caffeine	4-12	SRY-box transcription factor 9	Rattus norvegicus	57-62
29907324-12	2018	CONCLUSION: Caffeine administered to pregnant rats negatively alters the articular cartilage chondrocytes of their offspring, reducing the synthesis of collagen and Sox-9 expression regardless of the dose.	Caffeine	12-20	SRY-box transcription factor 9	Rattus norvegicus	165-170
29753010-9	2018	In addition, the caffeine metabolism pathway showed aberrations that are specific to wild-type BRAF PTC.	Caffeine	17-25	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	95-99
29806068-11	2018	Twelve pharmaceuticals were frequently detected in all five STPs, and caffeine, prazosin, and theophylline presented the highest concentrations among all the pharmaceuticals monitored: up to 7611, 550, and 319 ng/L in the STP influent, respectively.	Caffeine	70-78	thyroid hormone receptor interactor 10	Homo sapiens	60-63
29698704-0	2018	The cAMP-induced G protein subunits dissociation monitored in live Dictyostelium cells by BRET reveals two activation rates, a positive effect of caffeine and potential role of microtubules.	Caffeine	146-154	cathelicidin antimicrobial peptide	Homo sapiens	4-8
29698704-3	2018	In addition, we found that treating cells with caffeine increases the potency of cAMP-induced Galpha2betagamma activation; and that disrupting the microtubule network but not F-actin inhibits the cAMP-induced dissociation of Galpha2betagamma.	Caffeine	47-55	cathelicidin antimicrobial peptide	Homo sapiens	81-85
29698704-3	2018	In addition, we found that treating cells with caffeine increases the potency of cAMP-induced Galpha2betagamma activation; and that disrupting the microtubule network but not F-actin inhibits the cAMP-induced dissociation of Galpha2betagamma.	Caffeine	47-55	cathelicidin antimicrobial peptide	Homo sapiens	196-200
29516413-5	2018	Pre-treatment with COX inhibitor; naproxen (NPx) and adenosine receptor antagonist; caffeine (CAF), showed a significant impact on HP-induced cataleptic symptoms.	Caffeine	84-92	caffeine susceptibility	Mus musculus	94-97
29509641-2	2018	The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial.	Caffeine	97-105	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
29509641-2	2018	The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial.	Caffeine	152-160	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
29509641-12	2018	CYP1A2 genotype should be considered when deciding whether an athlete should use caffeine for enhancing endurance performance.	Caffeine	81-89	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	49-57	aryl hydrocarbon receptor	Homo sapiens	139-142
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	49-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	49-57	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	152-158
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	49-57	cytochrome p450 oxidoreductase	Homo sapiens	164-167
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	191-199	aryl hydrocarbon receptor	Homo sapiens	139-142
29971434-6	2018	We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.	Caffeine	191-199	cytochrome p450 oxidoreductase	Homo sapiens	164-167
29882086-7	2018	In mice treated with caffeine for 14 days, joint administration of agomelatine or mianserin and caffeine on day 15 decreased solute carrier family 6, member 15 (Slc6a15), messenger RNA (mRNA) level in the Cx, compared to the group which received only the respective antidepressant on this day.	Caffeine	21-29	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	125-159
29408363-4	2018	In the present work, we evaluated the effect of caffeine on anergia induced by the VMAT-2 inhibitor tetrabenazine (TBZ), which depletes DA.	Caffeine	48-56	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	83-89
29417440-7	2018	In contrast, caffeine alone reduced proliferative capacity and expression of the neuronal markers DCX and NeuN at 6 h, but increased expression of neurotrophins and neuronal transcription factors at 6 and 12 h. These results indicate that administration of phenobarbital during the vulnerable phase of brain development negatively interferes with neuronal development, which can be prevented in part by co-administration of caffeine.	Caffeine	13-21	doublecortin	Homo sapiens	98-101
29417440-7	2018	In contrast, caffeine alone reduced proliferative capacity and expression of the neuronal markers DCX and NeuN at 6 h, but increased expression of neurotrophins and neuronal transcription factors at 6 and 12 h. These results indicate that administration of phenobarbital during the vulnerable phase of brain development negatively interferes with neuronal development, which can be prevented in part by co-administration of caffeine.	Caffeine	13-21	RNA binding fox-1 homolog 3	Homo sapiens	106-110
29727960-7	2018	Caffeine (64 mug L-1) and ibuprofen (96.5 mug L-1) showed the highest concentration in raw samples, while diphenhydramine (0.9 mug L-1) showed the highest concentration in treated effluent samples.	Caffeine	0-8	immunoglobulin kappa variable 1-16	Homo sapiens	17-20
29857029-8	2018	In support of its role in MSN-dependent functions, several studies documented that mutant animals displayed alterations in striatum-related phenotypes reminiscent of psychiatric illness in humans, including deficits in prepulse inhibition of startle reflex and, most interestingly, a striking enhancement of behavioral responses elicited by caffeine, phencyclidine or amphetamine.	Caffeine	341-349	moesin	Homo sapiens	26-29
29882086-7	2018	In mice treated with caffeine for 14 days, joint administration of agomelatine or mianserin and caffeine on day 15 decreased solute carrier family 6, member 15 (Slc6a15), messenger RNA (mRNA) level in the Cx, compared to the group which received only the respective antidepressant on this day.	Caffeine	96-104	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	125-159
29882086-7	2018	In mice treated with caffeine for 14 days, joint administration of agomelatine or mianserin and caffeine on day 15 decreased solute carrier family 6, member 15 (Slc6a15), messenger RNA (mRNA) level in the Cx, compared to the group which received only the respective antidepressant on this day.	Caffeine	96-104	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	161-168
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	31-39	adenosine A1 receptor	Mus musculus	143-149
29882086-7	2018	In mice treated with caffeine for 14 days, joint administration of agomelatine or mianserin and caffeine on day 15 decreased solute carrier family 6, member 15 (Slc6a15), messenger RNA (mRNA) level in the Cx, compared to the group which received only the respective antidepressant on this day.	Caffeine	21-29	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	161-168
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	31-39	catechol-O-methyltransferase	Mus musculus	155-183
30271978-5	2018	RyR1 and RyR2 carrying mutations in putative Ca2+ and caffeine-binding sites were functionally analysed.	Caffeine	54-62	ryanodine receptor 2	Homo sapiens	9-13
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	31-39	catechol-O-methyltransferase	Mus musculus	185-189
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	adenosine A1 receptor	Mus musculus	143-149
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	catechol-O-methyltransferase	Mus musculus	155-183
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	catechol-O-methyltransferase	Mus musculus	185-189
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	adenosine A1 receptor	Mus musculus	143-149
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	catechol-O-methyltransferase	Mus musculus	155-183
29882086-8	2018	Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.	Caffeine	91-99	catechol-O-methyltransferase	Mus musculus	185-189
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	115-123	adenosine A1 receptor	Mus musculus	0-6
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	115-123	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	8-15
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	115-123	catechol-O-methyltransferase	Mus musculus	21-25
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	187-195	adenosine A1 receptor	Mus musculus	0-6
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	187-195	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	8-15
29882086-10	2018	Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.	Caffeine	187-195	catechol-O-methyltransferase	Mus musculus	21-25
29857001-10	2018	The NMD inhibitor caffeine prevented suppression of Xpre expression and thereby induced production of full-length alpha-actinin-3 protein in the presence of aminoglycoside.	Caffeine	18-26	actinin alpha 3	Homo sapiens	114-129
30271978-8	2018	Our results reveal the initial step of RyR channel activation by Ca2+ and explain the molecular mechanism of Ca2+ sensitization by caffeine and disease-causing mutations.	Caffeine	131-139	ryanodine receptor 1	Homo sapiens	39-42
29537866-5	2018	In single MASMCs freshly isolated from RyR3-/-, the EC50 of caffeine to induce Ca2+ release was lower than that in RyR3+/+ myocytes.	Caffeine	60-68	ryanodine receptor 3	Mus musculus	39-43
29729502-0	2018	Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin.	Caffeine	23-31	doublecortin	Rattus norvegicus	128-140
30050407-1	2018	Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer"s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease.	Caffeine	15-23	adenosine A2a receptor	Mus musculus	41-63
30050407-1	2018	Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer"s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease.	Caffeine	15-23	adenosine A2a receptor	Mus musculus	65-69
29888601-9	2018	These data suggested that javamide-II may be a potent compound to suppress TNF-alpha production more efficiently than caffeine by inhibiting ERK phosphorylation in Jurkat cells.	Caffeine	118-126	mitogen-activated protein kinase 1	Homo sapiens	141-144
29589062-4	2018	The NAT2 phenotype was determined using caffeine as a probe and log AFMU/(AFMU + 1X + 1 U) urinary metabolic ratio (MR) as an index.	Caffeine	40-48	N-acetyltransferase 2	Homo sapiens	4-8
29678503-0	2018	Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity.	Caffeine	0-8	signal transducer and activator of transcription 1	Homo sapiens	18-23
29678503-5	2018	TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee.	Caffeine	51-59	tumor necrosis factor	Homo sapiens	0-3
29678503-5	2018	TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee.	Caffeine	51-59	peroxisome proliferator activated receptor gamma	Homo sapiens	8-13
29678503-5	2018	TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee.	Caffeine	121-129	tumor necrosis factor	Homo sapiens	0-3
29678503-5	2018	TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee.	Caffeine	121-129	peroxisome proliferator activated receptor gamma	Homo sapiens	8-13
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	C-C motif chemokine ligand 4	Homo sapiens	25-34
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	interleukin 6	Homo sapiens	36-40
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	interferon gamma	Homo sapiens	42-51
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	colony stimulating factor 2	Homo sapiens	53-59
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	tumor necrosis factor	Homo sapiens	61-64
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	interleukin 2	Homo sapiens	66-70
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	interleukin 4	Homo sapiens	72-76
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	C-C motif chemokine ligand 2	Homo sapiens	78-83
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	interleukin 10	Homo sapiens	89-94
29678503-7	2018	Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment.	Caffeine	42-50	signal transducer and activator of transcription 1	Homo sapiens	60-65
29678503-7	2018	Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment.	Caffeine	42-50	signal transducer and activator of transcription 1	Homo sapiens	131-136
29678503-7	2018	Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment.	Caffeine	143-151	signal transducer and activator of transcription 1	Homo sapiens	60-65
29678503-7	2018	Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment.	Caffeine	143-151	signal transducer and activator of transcription 1	Homo sapiens	131-136
29692210-4	2018	Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the -163C &gt; A polymorphism of the CYP1A2 gene, regulating caffeine metabolism.	Caffeine	169-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	145-151
29692210-6	2018	The same trend was observed in all genotypes; the apparently steeper reduction of atrial fibrillation in slow caffeine metabolisers found at univariate analysis was proved wrong by multivariate Cox analysis.	Caffeine	110-118	cytochrome c oxidase subunit 8A	Homo sapiens	194-197
29967519-5	2018	In the bub3;1 bub3;2 double mutant, MAP65-3 localization was often dissipated away from the phragmoplast midline and abolished upon treatment of low doses of the cytokinesis inhibitory drug caffeine that were tolerated by the control plant.	Caffeine	190-198	Microtubule associated protein (MAP65/ASE1) family protein	Arabidopsis thaliana	36-43
29522901-0	2018	The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level.	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
29522901-0	2018	The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level.	Caffeine	130-138	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
29522901-1	2018	This study aimed to investigate whether the influence of CYP1A2 genotype in the blood pressure (BP) response to caffeine ingestion was affected by physical activity status and habitual caffeine consumption.	Caffeine	112-120	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
29522901-1	2018	This study aimed to investigate whether the influence of CYP1A2 genotype in the blood pressure (BP) response to caffeine ingestion was affected by physical activity status and habitual caffeine consumption.	Caffeine	185-193	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
29522901-4	2018	It was observed that AC genotype individuals had increased basal-DBP and post-caffeine SBP when compared to AA individuals.	Caffeine	78-86	selenium binding protein 1	Homo sapiens	87-90
29522901-5	2018	Additionally, acute caffeine ingestion increased SBP only in the AC group.	Caffeine	20-28	selenium binding protein 1	Homo sapiens	49-52
28686070-0	2018	Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.	Caffeine	101-109	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-93
29522901-7	2018	Furthermore, the results indicated that the habitual heavy caffeine consumers AC individuals had increased basal-DBP when compared to the AA ones.	Caffeine	59-67	D-box binding PAR bZIP transcription factor	Homo sapiens	113-116
28686070-2	2018	The pharmacokinetics were investigated for human cytochrome P450 probes after single intravenous and oral administrations of 0.20 and 1.0 mg/kg, respectively, of caffeine, warfarin, omeprazole, metoprolol and midazolam to aged (10-14 years old, n = 4) or rifampicin-treated/young (3 years old, n = 3) male common marmosets all genotyped as heterozygous for a cytochrome P450 2C19 variant.	Caffeine	162-170	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-64
29522901-8	2018	Our results suggest that the influence of CYP1A2 genotype in the basal and post-caffeine BP response to caffeine ingestion is modified by physical activity status and caffeine consumption level.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
29522901-8	2018	Our results suggest that the influence of CYP1A2 genotype in the basal and post-caffeine BP response to caffeine ingestion is modified by physical activity status and caffeine consumption level.	Caffeine	104-112	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
29516286-8	2018	Moreover, inhibition of the adenosine receptors by caffeine treatment reduced phagocytosis of NPP1 knock downed-cultured microglia.	Caffeine	51-59	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	94-98
30050935-7	2018	Mechanistic study showed that coadministration of caffeine and TMZ suppressed the phosphorylation of ATM and p53 and downregulated p21 expression, thus releasing DNA-damaged cells from G2 arrest into premature mitosis.	Caffeine	50-58	tumor protein p53	Homo sapiens	109-112
30050935-7	2018	Mechanistic study showed that coadministration of caffeine and TMZ suppressed the phosphorylation of ATM and p53 and downregulated p21 expression, thus releasing DNA-damaged cells from G2 arrest into premature mitosis.	Caffeine	50-58	H3 histone pseudogene 16	Homo sapiens	131-134
30050935-10	2018	In conclusion, our study demonstrated that caffeine enhanced the efficacy of TMZ through mitotic cell death by impeding ATM/p53/p21-mediated G2 arrest.	Caffeine	43-51	tumor protein p53	Homo sapiens	124-127
30050935-10	2018	In conclusion, our study demonstrated that caffeine enhanced the efficacy of TMZ through mitotic cell death by impeding ATM/p53/p21-mediated G2 arrest.	Caffeine	43-51	H3 histone pseudogene 16	Homo sapiens	128-131
29927970-0	2018	CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.	Caffeine	137-145	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-6
29927970-0	2018	CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.	Caffeine	137-145	cyclin-dependent kinase inhibitor 1B	Mus musculus	7-10
29927970-3	2018	Mitochondrial p27 improves mitochondrial membrane potential, increases adenosine triphosphate (ATP) content, and is required for the promigratory effect of caffeine.	Caffeine	156-164	cyclin-dependent kinase inhibitor 1B	Mus musculus	14-17
29927970-10	2018	Moreover, caffeine induces transcriptome changes in a p27-dependent manner, affecting mostly genes relevant for mitochondrial processes.	Caffeine	10-18	cyclin-dependent kinase inhibitor 1B	Mus musculus	54-57
30091726-7	2018	Caffeine reduced brain ischaemic injury and significantly reduced (p&lt;0.05) TNF-alpha activity.	Caffeine	0-8	tumor necrosis factor	Rattus norvegicus	78-87
30091726-9	2018	This study has shown neuro-protective roles of caffeine against ischaemia-reperfusion damage to brain tissue, inflammatory TNF-alpha activity, but not on LDH activity.	Caffeine	47-55	tumor necrosis factor	Rattus norvegicus	123-132
30091728-9	2018	The results showed that Caffeine at 2 and 6 mg/kg significantly inhibited MPO activity from 0.72+-0.05to 0.164+-0.045 and 0.46+-0.12 U/L respectively (p&lt;0.05).	Caffeine	24-32	myeloperoxidase	Oryctolagus cuniculus	74-77
29927970-11	2018	Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27.	Caffeine	0-8	cyclin-dependent kinase inhibitor 1B	Mus musculus	111-114
29927970-12	2018	Our data characterize mitochondrial p27 as a common denominator that improves mitochondria-dependent processes and define an increase in mitochondrial p27 as a new mode of action of caffeine.	Caffeine	182-190	cyclin-dependent kinase inhibitor 1B	Mus musculus	151-154
29812972-14	2018	Caffeine treatment in both the HO-induced and nhp6a  cells markedly increased OR &lt;=1 breaks.	Caffeine	0-8	high-mobility group nucleosome-binding protein	Saccharomyces cerevisiae S288C	46-51
29770111-2	2018	Here, we determined the effect of chronic caffeine treatment using the alpha-Syn fibril model of PD by intra-striatal injection of preformed A53T alpha-Syn fibrils.	Caffeine	42-50	joined toes	Mus musculus	77-80
29867353-5	2018	In addition, RyR3-mediated intracellular Ca2+ waves following caffeine stimulation were correlated with the expression pattern of RyR3, in which high flat Ca2+ fluctuations and oscillatory Ca2+ waves were more frequently recorded in OPCs and/or imOLs than in OLs.	Caffeine	62-70	ryanodine receptor 3	Homo sapiens	13-17
29867353-5	2018	In addition, RyR3-mediated intracellular Ca2+ waves following caffeine stimulation were correlated with the expression pattern of RyR3, in which high flat Ca2+ fluctuations and oscillatory Ca2+ waves were more frequently recorded in OPCs and/or imOLs than in OLs.	Caffeine	62-70	ryanodine receptor 3	Homo sapiens	130-134
29770111-2	2018	Here, we determined the effect of chronic caffeine treatment using the alpha-Syn fibril model of PD by intra-striatal injection of preformed A53T alpha-Syn fibrils.	Caffeine	42-50	synuclein, alpha	Mus musculus	71-80
29770111-3	2018	We demonstrated that chronic caffeine treatment blunted a cascade of pathological events leading to alpha-synucleinopathy, including pSer129alpha-Syn-rich aggregates, apoptotic neuronal cell death, microglia, and astroglia reactivation.	Caffeine	29-37	joined toes	Mus musculus	146-149
29770111-4	2018	Importantly, chronic caffeine treatment did not affect autophagy processes in the normal striatum, but selectively reversed alpha-Syn-induced defects in macroautophagy (by enhancing microtubule-associated protein 1 light chain 3, and reducing the receptor protein sequestosome 1, SQSTM1/p62) and chaperone-mediated autophagy (CMA, by enhancing LAMP2A).	Caffeine	21-29	synuclein, alpha	Mus musculus	124-133
29770111-4	2018	Importantly, chronic caffeine treatment did not affect autophagy processes in the normal striatum, but selectively reversed alpha-Syn-induced defects in macroautophagy (by enhancing microtubule-associated protein 1 light chain 3, and reducing the receptor protein sequestosome 1, SQSTM1/p62) and chaperone-mediated autophagy (CMA, by enhancing LAMP2A).	Caffeine	21-29	sequestosome 1	Mus musculus	264-278
29770111-4	2018	Importantly, chronic caffeine treatment did not affect autophagy processes in the normal striatum, but selectively reversed alpha-Syn-induced defects in macroautophagy (by enhancing microtubule-associated protein 1 light chain 3, and reducing the receptor protein sequestosome 1, SQSTM1/p62) and chaperone-mediated autophagy (CMA, by enhancing LAMP2A).	Caffeine	21-29	sequestosome 1	Mus musculus	280-286
29770111-4	2018	Importantly, chronic caffeine treatment did not affect autophagy processes in the normal striatum, but selectively reversed alpha-Syn-induced defects in macroautophagy (by enhancing microtubule-associated protein 1 light chain 3, and reducing the receptor protein sequestosome 1, SQSTM1/p62) and chaperone-mediated autophagy (CMA, by enhancing LAMP2A).	Caffeine	21-29	sequestosome 1	Mus musculus	287-290
29770111-4	2018	Importantly, chronic caffeine treatment did not affect autophagy processes in the normal striatum, but selectively reversed alpha-Syn-induced defects in macroautophagy (by enhancing microtubule-associated protein 1 light chain 3, and reducing the receptor protein sequestosome 1, SQSTM1/p62) and chaperone-mediated autophagy (CMA, by enhancing LAMP2A).	Caffeine	21-29	lysosomal-associated membrane protein 2	Mus musculus	344-350
29668752-1	2018	PURPOSE: The aim of this investigation was to analyze the influence of the genetic variations of the -163C&gt;A polymorphism of the CYP1A2 gene on the ergogenic effects of caffeine in elite basketball players.	Caffeine	172-180	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138
29477472-0	2018	Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression.	Caffeine	14-22	lysophosphatidic acid receptor 1	Rattus norvegicus	114-119
29477472-13	2018	In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-beta1, CTGF, and alpha-SMA gene expressions and LPAR1 tissue expression.	Caffeine	24-32	lysophosphatidic acid receptor 1	Rattus norvegicus	88-93
29477472-13	2018	In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-beta1, CTGF, and alpha-SMA gene expressions and LPAR1 tissue expression.	Caffeine	24-32	transforming growth factor, beta 1	Rattus norvegicus	95-104
29477472-13	2018	In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-beta1, CTGF, and alpha-SMA gene expressions and LPAR1 tissue expression.	Caffeine	24-32	cellular communication network factor 2	Rattus norvegicus	106-110
29477472-13	2018	In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-beta1, CTGF, and alpha-SMA gene expressions and LPAR1 tissue expression.	Caffeine	24-32	actin gamma 2, smooth muscle	Rattus norvegicus	116-125
29477472-13	2018	In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-beta1, CTGF, and alpha-SMA gene expressions and LPAR1 tissue expression.	Caffeine	24-32	lysophosphatidic acid receptor 1	Rattus norvegicus	147-152
29477472-14	2018	SIGNIFICANCE: Silymarin, caffeine, and their combination protect against liver fibrosis through down-regulation of LPAR1, TGF-beta1, and CTGF.	Caffeine	25-33	lysophosphatidic acid receptor 1	Rattus norvegicus	115-120
29477472-14	2018	SIGNIFICANCE: Silymarin, caffeine, and their combination protect against liver fibrosis through down-regulation of LPAR1, TGF-beta1, and CTGF.	Caffeine	25-33	transforming growth factor, beta 1	Rattus norvegicus	122-131
29477472-14	2018	SIGNIFICANCE: Silymarin, caffeine, and their combination protect against liver fibrosis through down-regulation of LPAR1, TGF-beta1, and CTGF.	Caffeine	25-33	cellular communication network factor 2	Rattus norvegicus	137-141
29345166-5	2018	After intravenous injection of caffeine in rats, caffeine increased adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation, and glucose transport.	Caffeine	31-39	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	68-116
29345166-5	2018	After intravenous injection of caffeine in rats, caffeine increased adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation, and glucose transport.	Caffeine	31-39	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	118-122
29345166-5	2018	After intravenous injection of caffeine in rats, caffeine increased adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation, and glucose transport.	Caffeine	49-57	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	68-116
29345166-5	2018	After intravenous injection of caffeine in rats, caffeine increased adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation, and glucose transport.	Caffeine	49-57	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	118-122
29345166-6	2018	In in vitro studies, caffeine raised AMPK and ACC phosphorylation, increasing glucose transport activity and reducing energy status in rat muscle cells.	Caffeine	21-29	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	37-41
29643533-10	2018	Our study showed that etoposide induced-MICA/B expression in MCF-7 was inhibited by caffeine at different concentrations.	Caffeine	84-92	MHC class I polypeptide-related sequence A	Homo sapiens	40-44
29668752-10	2018	CONCLUSION: The CYP1A2 -163C&gt;A polymorphism minimally altered the ergogenicity derived from the consumption of a moderate dose of caffeine in elite basketball players.	Caffeine	133-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-22
29686613-9	2018	The model can explain most behavioral effects of A2AR and D2R ligands, including the psychostimulant effects of caffeine.	Caffeine	112-120	adenosine A2a receptor	Homo sapiens	49-53
29344738-4	2018	The half-maximal effective concentration (EC50) values of two RYR1 activators, caffeine and 4-chloro-m-cresol (4CmC), were calculated from the acquired dose-response curves.	Caffeine	79-87	ryanodine receptor 1	Homo sapiens	62-66
28734904-5	2018	Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).	Caffeine	224-232	solute carrier family 6 member 3	Homo sapiens	109-129
28734904-5	2018	Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).	Caffeine	224-232	WASP actin nucleation promoting factor	Homo sapiens	184-187
28734904-5	2018	Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).	Caffeine	224-232	adenosine A2a receptor	Homo sapiens	190-212
28734904-5	2018	Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).	Caffeine	224-232	SH3GL interacting endocytic adaptor 1	Homo sapiens	239-244
29475793-4	2018	Here we investigated whether caffeine and nicotine, alone or combined with haloperidol, elicited significant changes in the levels of both transcripts and proteins of the PSD members Homer1 and Arc, which have been implicated in synaptic plasticity, schizophrenia pathophysiology, and antipsychotics molecular action.	Caffeine	29-37	homer scaffold protein 1	Homo sapiens	183-189
29475793-5	2018	Homer1a mRNA expression was significantly reduced by caffeine and nicotine, alone or combined with haloperidol, compared to haloperidol.	Caffeine	53-61	homer scaffold protein 1	Homo sapiens	0-7
29475793-8	2018	Both Homer1a and Arc protein levels were significantly increased by caffeine, nicotine, and nicotine plus haloperidol.	Caffeine	68-76	homer scaffold protein 1	Homo sapiens	5-12
29681853-0	2018	Caffeine Promotes Conversion of Palmitic Acid to Palmitoleic Acid by Inducing Expression of fat-5 in Caenorhabditis elegans and scd1 in Mice.	Caffeine	0-8	Delta(9)-fatty-acid desaturase fat-5	Caenorhabditis elegans	92-97
29681853-0	2018	Caffeine Promotes Conversion of Palmitic Acid to Palmitoleic Acid by Inducing Expression of fat-5 in Caenorhabditis elegans and scd1 in Mice.	Caffeine	0-8	Suppressor of Constitutive Dauer formation	Caenorhabditis elegans	128-132
29681853-3	2018	After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C. elegans was significantly higher than that of controls, whereas fat-6 and fat-7 displayed no significant difference.	Caffeine	76-84	Delta(9)-fatty-acid desaturase fat-5	Caenorhabditis elegans	242-247
29681853-3	2018	After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C. elegans was significantly higher than that of controls, whereas fat-6 and fat-7 displayed no significant difference.	Caffeine	76-84	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	335-340
29681853-3	2018	After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C. elegans was significantly higher than that of controls, whereas fat-6 and fat-7 displayed no significant difference.	Caffeine	76-84	Delta(9)-fatty-acid desaturase fat-7	Caenorhabditis elegans	345-350
29681853-3	2018	After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C. elegans was significantly higher than that of controls, whereas fat-6 and fat-7 displayed no significant difference.	Caffeine	251-259	Delta(9)-fatty-acid desaturase fat-5	Caenorhabditis elegans	242-247
29681853-7	2018	We found that mdt-15 was essential for the effects of caffeine, which was independent of nhr-49 and nhr-80.	Caffeine	54-62	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	14-20
29681853-8	2018	Caffeine may increase fat-5 expression by acting on mdt-15.	Caffeine	0-8	Delta(9)-fatty-acid desaturase fat-5	Caenorhabditis elegans	22-27
29681853-8	2018	Caffeine may increase fat-5 expression by acting on mdt-15.	Caffeine	0-8	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	52-58
29681853-9	2018	In high fat diet (HFD), but not in normal diet (ND) mice, caffeine induced expression of scd1 in both subcutaneous and epididymal white adipose tissue, which was consistent with the palmitoleic/palmitic ratio results by gas chromatograph analysis.	Caffeine	58-66	stearoyl-Coenzyme A desaturase 1	Mus musculus	89-93
29681853-10	2018	In mature adipocytes, caffeine treatment induced both mRNA and protein expression of scd1 and pgc-1alpha.	Caffeine	22-30	Suppressor of Constitutive Dauer formation	Caenorhabditis elegans	85-89
29569539-3	2018	Specifically, the rs762551 SNP in the CYP1A2 gene has been demonstrated to influence caffeine metabolism, with carriers of the C allele considered to be of a "slow" metaboliser phenotype.	Caffeine	85-93	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44
29344738-8	2018	CONCLUSIONS: Our results of functional testing indicated RYR1 hypersensitivity to caffeine and 4CmC.	Caffeine	82-90	ryanodine receptor 1	Homo sapiens	57-61
29134560-13	2018	Caffeine also exacerbated the oxidative damage of nuclear DNA induced by MDMA but diminished DAT decrease in the striatum and worsened a decrease in SERT density produced by MDMA in the frontal cortex.	Caffeine	0-8	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	93-96
28895043-0	2018	Effects of Long-Term Caffeine Consumption on the Adenosine A1 Receptor in the Rat Brain: an In Vivo PET Study with [18F]CPFPX.	Caffeine	21-29	adenosine A1 receptor	Rattus norvegicus	49-70
28895043-3	2018	Thus, aim of the present study was an in vivo investigation of effects of long-term caffeine consumption on the adenosine A1 receptor (A1AR) in the rat brain.	Caffeine	84-92	adenosine A1 receptor	Rattus norvegicus	112-133
28895043-6	2018	The caffeine-treated animals received caffeinated tap water (30 mg/kg bodyweight/day, corresponding to 4-5 cups of coffee per day in humans) for 12 weeks.	Caffeine	4-12	nuclear RNA export factor 1	Homo sapiens	50-53
29134560-13	2018	Caffeine also exacerbated the oxidative damage of nuclear DNA induced by MDMA but diminished DAT decrease in the striatum and worsened a decrease in SERT density produced by MDMA in the frontal cortex.	Caffeine	0-8	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	149-153
27569025-0	2018	The Odorant ( R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46.	Caffeine	40-48	taste 2 receptor member 43	Homo sapiens	95-102
29514871-6	2018	The pharmacokinetics of caffeine are highly variable among individuals due to a polymorphism at the level of the CYP1A2 isoform of cytochrome P450, which metabolizes 95% of the caffeine ingested.	Caffeine	24-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	113-119
29514871-6	2018	The pharmacokinetics of caffeine are highly variable among individuals due to a polymorphism at the level of the CYP1A2 isoform of cytochrome P450, which metabolizes 95% of the caffeine ingested.	Caffeine	177-185	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	113-119
29514871-8	2018	At the pharmacodynamic level, there are several polymorphisms at the main brain target of caffeine, the adenosine A2A receptor or ADORA2.	Caffeine	90-98	adenosine A2a receptor	Homo sapiens	104-126
29514871-8	2018	At the pharmacodynamic level, there are several polymorphisms at the main brain target of caffeine, the adenosine A2A receptor or ADORA2.	Caffeine	90-98	adenosine A2a receptor	Homo sapiens	130-136
29562659-8	2018	RESULTS: In the above experiment, having consumed three portions of ED (240 mg of caffeine), the participants presented a significant increase in DBP (p = 0.003), by over 8%, which coincided with a lack of any significant impact on SBP (p = 0.809).	Caffeine	82-90	D-box binding PAR bZIP transcription factor	Homo sapiens	146-149
29271023-8	2018	In Ca2+ measurement, Ad-PKD2-shRNAs reduced caffeine-induced cytosolic Ca2+ rise.	Caffeine	44-52	polycystin 2, transient receptor potential cation channel	Homo sapiens	24-28
27569025-0	2018	The Odorant ( R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46.	Caffeine	40-48	taste 2 receptor member 46	Homo sapiens	107-114
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 7	Homo sapiens	83-89
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 10	Homo sapiens	91-98
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 14	Homo sapiens	100-107
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 43	Homo sapiens	109-116
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 46	Homo sapiens	122-129
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 43	Homo sapiens	250-257
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	158-166	taste 2 receptor member 46	Homo sapiens	304-311
27569025-4	2018	Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed ( R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells.	Caffeine	214-222	taste 2 receptor member 46	Homo sapiens	122-129
28525714-3	2018	We previously demonstrated several bitter-tasting compounds such as caffeine to induce acid secretion in the stomach and in a human gastric tumor cell line (HGT-1).	Caffeine	68-76	solute carrier family 25 member 16	Homo sapiens	157-162
29318639-0	2018	Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson"s disease risk.	Caffeine	20-28	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	102-108
29309856-0	2018	Role of histamine H1 receptor in caffeine induced locomotor sensitization.	Caffeine	33-41	histamine receptor H1	Mus musculus	8-29
29309856-1	2018	The present study elucidated the role of histamine H1 receptor in the caffeine induced locomotor sensitization.	Caffeine	70-78	histamine receptor H1	Mus musculus	41-62
29309856-7	2018	injection of histaminergic agents concomitantly with caffeine during induction phase i.e. histamine H1 receptor agonist, FMPH (6.5 mug/mouse) significantly potentiated while H1 receptor antagonist, cetirizine (0.1 mug/mouse) attenuated the locomotor sensitization induced by caffeine (15 mg/kg, i.p.).	Caffeine	53-61	histamine receptor H1	Mus musculus	90-111
29318639-0	2018	Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson"s disease risk.	Caffeine	20-28	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-141
29318639-3	2018	METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses" Health Study, the Health Professionals" Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort.	Caffeine	39-47	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	60-66
29318639-8	2018	In analyses stratified by the GRIN2A-rs4998386 genotype, the multivariable-adjusted relative risk of PD comparing the highest to the lowest tertile of caffeine was 0.69 (95% confidence interval, 0.55-0.88; p < .01) among individuals homozygous for the C allele, and 0.85 (95% confidence interval, 0.55-1.32; p = .47; pRERI  = .43) among carriers for the T allele.	Caffeine	151-159	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	30-36
28992490-5	2018	Caffeine was found to be present at concentrations higher than the limit of quantification (LOQ=3.07ngL-1) in 15 of the 23 samples analysed, with the highest seawater concentration being 857ngL-1 (the highest measured in seawater in Spain).	Caffeine	0-8	leucine rich repeat containing 4C	Homo sapiens	100-105
29599709-15	2018	Caffeine/modafinil treatment significantly decreased the microglial immunoreactivity in DG, CA1 and CA3 regions of the hippocampus during SD, however, no significant increase in immunoreactivity of astrocytes was observed.	Caffeine	0-8	carbonic anhydrase 1	Rattus norvegicus	92-95
29599709-15	2018	Caffeine/modafinil treatment significantly decreased the microglial immunoreactivity in DG, CA1 and CA3 regions of the hippocampus during SD, however, no significant increase in immunoreactivity of astrocytes was observed.	Caffeine	0-8	carbonic anhydrase 3	Rattus norvegicus	100-103
29599709-17	2018	Stereological analysis demonstrated a significant improvement in the number of ionized calcium binding adapter molecule I (Iba-1) positive cells (different states) in different regions of the hippocampus after caffeine or modafinil treatment during SD without showing any significant change in total microglial cell number.	Caffeine	210-218	allograft inflammatory factor 1	Rattus norvegicus	123-128
29495349-8	2018	Additionally, the neuroprotective mechanisms of caffeine and theaflavins may contribute to the ability to antagonize the adenosine receptor A2AR and the antioxidant properties, respectively.	Caffeine	48-56	adenosine A2a receptor	Homo sapiens	140-144
29343424-0	2018	IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats.	Caffeine	114-122	insulin-like growth factor 1	Rattus norvegicus	0-4
29343424-0	2018	IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats.	Caffeine	114-122	Eph receptor B1	Rattus norvegicus	10-13
29343424-1	2018	Our previous study proposed a glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mechanism for prenatal caffeine exposure (PCE)-induced adrenal developmental dysfunction.	Caffeine	124-132	insulin-like growth factor 1	Rattus norvegicus	78-82
29456505-4	2018	Here, we report that locomotor and EEG spectral responses to the psychostimulants modafinil and caffeine are attenuated in TAAR1 KO mice.	Caffeine	96-104	trace amine-associated receptor 1	Mus musculus	123-128
29255089-3	2018	Here, we report that substitution of Gly-4941 with Asp or Lys results in functional channels as indicated by caffeine-induced Ca2+ release response in HEK293 cells, whereas a low response of the corresponding Gly-4934 variants suggested loss of function.	Caffeine	109-117	carbonic anhydrase 2	Homo sapiens	126-129
29456505-0	2018	Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine.	Caffeine	81-89	trace amine-associated receptor 1	Mus musculus	12-45
29456505-12	2018	Furthermore, gamma band EEG activity following both modafinil and caffeine treatment was attenuated in TAAR1 KO compared to WT mice.	Caffeine	66-74	trace amine-associated receptor 1	Mus musculus	103-108
29556329-4	2018	Caffeine, a known ligand for T2R10, rendered the tumor cells more susceptible to two standard chemotherapeutics, Gemcitabine and 5-Fluoruracil.	Caffeine	0-8	taste 2 receptor member 10	Homo sapiens	29-34
28826637-8	2018	Coincident with memory improvement in males, caffeine increased pro- and BDNF in the hippocampus and cortex.	Caffeine	45-53	brain-derived neurotrophic factor	Rattus norvegicus	73-77
28826637-10	2018	While GFAP was not altered, moderate caffeine intake increased SNAP-25 in the cortex of female rats.	Caffeine	37-45	synaptosome associated protein 25	Rattus norvegicus	63-70
28826637-11	2018	Our findings revealed that caffeine promoted cognitive benefits in males associated with increased BDNF levels, while females showed less anxiety.	Caffeine	27-35	brain-derived neurotrophic factor	Rattus norvegicus	99-103
29192401-3	2018	In Jundiai River samples, most of the compounds were frequently detected, wherein caffeine had the highest concentration, with maximum average concentrations of 14,050 ng L-1, followed by atenolol (431 ng L-1), ibuprofen (268 ng L-1) and diclofenac (214 ng L-1).	Caffeine	82-90	immunoglobulin kappa variable 1-16	Homo sapiens	171-174
29556329-5	2018	Knocking down T2R10 in the cell line BxPC-3 reduced the caffeine-induced effect.	Caffeine	56-64	taste 2 receptor member 10	Homo sapiens	14-19
29556329-6	2018	As possible underlying mechanism, we found that caffeine via triggering T2R10 inhibited Akt phosphorylation and subsequently downregulated expression of ABCG2, the so-called multi-drug resistance protein that participates in rendering cells resistant to a variety of chemotherapeutics.	Caffeine	48-56	taste 2 receptor member 10	Homo sapiens	72-77
29556329-6	2018	As possible underlying mechanism, we found that caffeine via triggering T2R10 inhibited Akt phosphorylation and subsequently downregulated expression of ABCG2, the so-called multi-drug resistance protein that participates in rendering cells resistant to a variety of chemotherapeutics.	Caffeine	48-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	153-158
29401432-10	2018	Time-lapse total internal reflection fluorescence imaging revealed dynamic movements of GFP-RyR2 clusters in the periphery, which were affected by external Ca2+ and RyR2 activator (caffeine) and inhibitor (tetracaine), but little detectable movement of GFP-RyR2 clusters in the interior.	Caffeine	181-189	ryanodine receptor 2, cardiac	Mus musculus	92-96
29198059-1	2018	Caffeine has been shown to stimulate multiple major regulators of cell energetics including AMP-activated protein kinase (AMPK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII).	Caffeine	0-8	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	132-175
29198059-1	2018	Caffeine has been shown to stimulate multiple major regulators of cell energetics including AMP-activated protein kinase (AMPK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII).	Caffeine	0-8	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	177-183
29198059-2	2018	Additionally, caffeine induces peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and mitochondrial biogenesis.	Caffeine	14-22	PPARG coactivator 1 alpha	Homo sapiens	101-111
29198059-4	2018	This work measured the effects of low-level caffeine on cellular metabolism and gene expression in myotubes, as well as the dependence of caffeine"s effects on the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta).	Caffeine	138-146	peroxisome proliferator activated receptor delta	Homo sapiens	236-244
29198059-8	2018	Mitochondrial staining was suppressed in PPARbeta/delta-inhibited cells which was rescued by concurrent caffeine treatment.	Caffeine	104-112	peroxisome proliferator activated receptor delta	Homo sapiens	41-49
29198059-9	2018	Caffeine-treated cells also displayed elevated peak oxidative metabolism which was partially abolished following PPARbeta/delta inhibition.	Caffeine	0-8	peroxisome proliferator activated receptor delta	Homo sapiens	113-121
29198059-10	2018	Similar to past observations, glucose uptake and GLUT4 content were elevated in caffeine-treated cells, however, glycolytic metabolism was unaltered following caffeine treatment.	Caffeine	80-88	solute carrier family 2 member 4	Homo sapiens	49-54
29198059-11	2018	Physiological levels of caffeine appear to enhance cell metabolism through mechanisms partially dependent on PPARbeta/delta.	Caffeine	24-32	peroxisome proliferator activated receptor delta	Homo sapiens	109-117
29154944-11	2018	Additionally, after estrogen receptor (ER) beta knockdown, the antagonistic effects of beta-estradiol on caffeine were nearly abolished.	Caffeine	105-113	estrogen receptor 2	Homo sapiens	20-47
29401432-10	2018	Time-lapse total internal reflection fluorescence imaging revealed dynamic movements of GFP-RyR2 clusters in the periphery, which were affected by external Ca2+ and RyR2 activator (caffeine) and inhibitor (tetracaine), but little detectable movement of GFP-RyR2 clusters in the interior.	Caffeine	181-189	ryanodine receptor 2, cardiac	Mus musculus	165-169
29401432-10	2018	Time-lapse total internal reflection fluorescence imaging revealed dynamic movements of GFP-RyR2 clusters in the periphery, which were affected by external Ca2+ and RyR2 activator (caffeine) and inhibitor (tetracaine), but little detectable movement of GFP-RyR2 clusters in the interior.	Caffeine	181-189	ryanodine receptor 2, cardiac	Mus musculus	165-169
28986085-12	2018	Caffeine, an ATM/ATR inhibitor, rescued ovatodiolide-mediated cell cycle arrest and apoptosis, but not reactive oxygen species generation.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	13-16
28986085-12	2018	Caffeine, an ATM/ATR inhibitor, rescued ovatodiolide-mediated cell cycle arrest and apoptosis, but not reactive oxygen species generation.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	17-20
29138237-3	2018	Consistent with studies that found widespread effects of different auxotrophies on RNA expression patterns in rich media, we find that the SER1 loss-of-function allele dominates the quantitative trait locus (QTL) landscape under many of these conditions, with a notable exacerbation of the effect in the presence of rapamycin and caffeine.	Caffeine	330-338	O-phospho-L-serine:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	139-143
30504686-10	2018	In contrast, 7-nitroindazole decreased c-Fos-positive NOS neurons and attenuated caffeine-induced increase in c-Fos-positive NOS neurons.	Caffeine	81-89	FBJ osteosarcoma oncogene	Mus musculus	110-115
29138237-2	2018	Through a cross with a honey wine (white tecc) brewing strain from Ethiopia, we map the minimal medium growth defect to SER1, which encodes 3-phosphoserine aminotransferase and is orthologous to the human disease gene, PSAT1 To investigate the impact of this polymorphism under conditions of abundant external nutrients, we examine growth in rich medium alone or with additional stresses, including the drugs caffeine and rapamycin and relatively high concentrations of copper, salt, and ethanol.	Caffeine	409-417	O-phospho-L-serine:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	120-124
29138237-2	2018	Through a cross with a honey wine (white tecc) brewing strain from Ethiopia, we map the minimal medium growth defect to SER1, which encodes 3-phosphoserine aminotransferase and is orthologous to the human disease gene, PSAT1 To investigate the impact of this polymorphism under conditions of abundant external nutrients, we examine growth in rich medium alone or with additional stresses, including the drugs caffeine and rapamycin and relatively high concentrations of copper, salt, and ethanol.	Caffeine	409-417	phosphoserine aminotransferase 1	Homo sapiens	219-224
29354052-3	2017	We here provide the first characterization of the impact of realistic concentrations of caffeine experienced by moderate coffee drinkers (50 muM) on excitability of pyramidal neurons and excitatory synaptic transmission in the human temporal cortex.	Caffeine	88-96	latexin	Homo sapiens	141-144
29424319-0	2018	Caffeine Effect on HIFs/VEGF Pathway in Human Glioblastoma Cells Exposed to Hypoxia.	Caffeine	0-8	vascular endothelial growth factor A	Homo sapiens	24-28
29177989-1	2018	BACKGROUND: By modulating the levels of sex steroid hormones and sex hormone-binding globulin (SHBG), caffeine could be a factor in the development of several conditions in men, including prostate cancer.	Caffeine	102-110	sex hormone binding globulin	Homo sapiens	65-93
29177989-1	2018	BACKGROUND: By modulating the levels of sex steroid hormones and sex hormone-binding globulin (SHBG), caffeine could be a factor in the development of several conditions in men, including prostate cancer.	Caffeine	102-110	sex hormone binding globulin	Homo sapiens	95-99
29177989-2	2018	The aim of this study was to evaluate if caffeine consumption is associated with concentrations of sex steroid hormones and SHBG in men.	Caffeine	41-49	sex hormone binding globulin	Homo sapiens	124-128
28674941-0	2018	Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans.	Caffeine	19-27	Heat shock transcription factor hsf-1	Caenorhabditis elegans	91-96
28674941-9	2018	The effects that we observe with both coffee and pure caffeine on the heat shock response are both dependent on HSF-1.	Caffeine	54-62	Heat shock transcription factor hsf-1	Caenorhabditis elegans	112-117
28674941-10	2018	In a C. elegans Huntington"s disease model, worms treated with caffeine were protected from polyglutamine aggregates and toxicity, an effect that was also HSF-1-dependent.	Caffeine	63-71	Heat shock transcription factor hsf-1	Caenorhabditis elegans	155-160
29174767-3	2018	Sorcin KO mice presented ventricular arrhythmia and sudden death when challenged by acute stress induced by isoproterenol plus caffeine.	Caffeine	127-135	sorcin	Mus musculus	0-6
29063606-5	2018	Although CP studies are limited, meta-analysis-based reduction in CYP1A2, CYP2C19, and CYP3A4 enzyme abundances in a virtual oncology population effectively captures CP-PK for caffeine, theophylline, midazolam, simvastatin, omeprazole, and a subset of oncology compounds.	Caffeine	176-184	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
29063606-5	2018	Although CP studies are limited, meta-analysis-based reduction in CYP1A2, CYP2C19, and CYP3A4 enzyme abundances in a virtual oncology population effectively captures CP-PK for caffeine, theophylline, midazolam, simvastatin, omeprazole, and a subset of oncology compounds.	Caffeine	176-184	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	74-81
29063606-5	2018	Although CP studies are limited, meta-analysis-based reduction in CYP1A2, CYP2C19, and CYP3A4 enzyme abundances in a virtual oncology population effectively captures CP-PK for caffeine, theophylline, midazolam, simvastatin, omeprazole, and a subset of oncology compounds.	Caffeine	176-184	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93
29261723-1	2017	BACKGROUND: There is growing evidence that supports the benefits of early use of caffeine in preterm neonates with RDS; however, no formal recommendations specifying the exact timing of therapy initiation have been provided.	Caffeine	81-89	peripherin 2	Homo sapiens	115-118
28853006-6	2018	Here, we briefly review the drivers of this inter-individual variation in caffeine response, focusing on the impact of common polymorphisms within two genes, CYP1A2 and ADORA2A.	Caffeine	74-82	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	158-164
28853006-6	2018	Here, we briefly review the drivers of this inter-individual variation in caffeine response, focusing on the impact of common polymorphisms within two genes, CYP1A2 and ADORA2A.	Caffeine	74-82	adenosine A2a receptor	Homo sapiens	169-176
29558753-0	2018	Stimulation of Intestinal Cl- Secretion Through CFTR by Caffeine Intake in Salt-Sensitive Hypertensive Rats.	Caffeine	56-64	CF transmembrane conductance regulator	Rattus norvegicus	48-52
29558753-9	2018	Further, the results from the Ussing chamber assay indicated that caffeine promoted Cl- secretion through enterocyte apical cystic fibrosis transmembrane conductance regulator (CFTR), and thus inhibited sodium absorption.	Caffeine	66-74	CF transmembrane conductance regulator	Rattus norvegicus	124-175
29558753-9	2018	Further, the results from the Ussing chamber assay indicated that caffeine promoted Cl- secretion through enterocyte apical cystic fibrosis transmembrane conductance regulator (CFTR), and thus inhibited sodium absorption.	Caffeine	66-74	CF transmembrane conductance regulator	Rattus norvegicus	177-181
29558753-10	2018	Moreover, depletion of cAMP or inhibition of CFTR completely abolished the effect of caffeine on Cl- secretion.	Caffeine	85-93	CF transmembrane conductance regulator	Rattus norvegicus	45-49
29558753-11	2018	CONCLUSION: The results indicate that chronic caffeine consumption reduces sodium absorption by promoting CFTR-mediated Cl- secretion in the intestine, which contributes to the anti-hypertensive effect of caffeine in salt-sensitive rats.	Caffeine	46-54	CF transmembrane conductance regulator	Rattus norvegicus	106-110
29558753-11	2018	CONCLUSION: The results indicate that chronic caffeine consumption reduces sodium absorption by promoting CFTR-mediated Cl- secretion in the intestine, which contributes to the anti-hypertensive effect of caffeine in salt-sensitive rats.	Caffeine	205-213	CF transmembrane conductance regulator	Rattus norvegicus	106-110
29215336-8	2017	RESULTS: We observed a significant increase on apolipoprotein A-1 and paraoxonase-1 protein levels in the cells incubated with 50 microM of caffeine and a significant increase on paraoxonase-1 protein level in the cells incubated with 200 microM of caffeine.	Caffeine	249-257	paraoxonase 1	Homo sapiens	179-192
28910581-6	2018	Increased caffeine tolerance of the QC deficient strain was consistent with the observation that the activity of Gln3p, a transcription factor controlled by the TOR pathway, is decreased in the QC deficient strain compared to WT.	Caffeine	10-18	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	113-118
29215336-0	2017	Caffeine Increases Apolipoprotein A-1 and Paraoxonase-1 but not Paraoxonase-3 Protein Levels in Human-Derived Liver (HepG2) Cells.	Caffeine	0-8	apolipoprotein A1	Homo sapiens	19-37
29061705-0	2018	Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice.	Caffeine	16-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
29061705-5	2018	Polyphenols and caffeine (CAF) played critical roles in improving these parameters.	Caffeine	16-24	caffeine susceptibility	Mus musculus	26-29
29107002-6	2017	Caffeine withdrawal caused a decrease in Adora1 mRNA level in the cerebral cortex (Cx).	Caffeine	0-8	adenosine A1 receptor	Mus musculus	41-47
29107002-7	2017	Administration of escitalopram or fluoxetine followed by caffeine withdrawal caused an increase in this gene expression, whereas administration of escitalopram, but not fluoxetine, on day 15th together with caffeine caused a decrease in Adora1 mRNA level in the Cx.	Caffeine	207-215	adenosine A1 receptor	Mus musculus	237-243
29107002-8	2017	Furthermore, antidepressant-like activity observed after joint administration of the tested drugs with caffeine was associated with decreased Slc6a15 mRNA level in the Cx.	Caffeine	103-111	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	142-149
29037810-5	2017	OlTRPA1 showed a sensitivity to four noxious chemicals (allyl isothiocyanate, caffeine, carvacrol, methyl anthranilate).	Caffeine	78-86	transient receptor potential cation channel subfamily A member 1	Oryzias latipes	0-7
29215606-6	2017	DISCUSSION: These results demonstrate that a nutrient enriched breakfast bar with low caffeine content can exert striking beneficial effects on acute cognitive function and alertness.	Caffeine	86-94	bifunctional apoptosis regulator	Homo sapiens	73-76
28713161-6	2017	In addition, Ca2+ transients were induced by a ryanodine receptor (RyR) activator, caffeine, in 10%-15% of hESCs and were blocked by ryanodine, whereas caffeine and ATP did not have additive effects.	Caffeine	83-91	ryanodine receptor 1	Homo sapiens	47-65
28713161-6	2017	In addition, Ca2+ transients were induced by a ryanodine receptor (RyR) activator, caffeine, in 10%-15% of hESCs and were blocked by ryanodine, whereas caffeine and ATP did not have additive effects.	Caffeine	83-91	ryanodine receptor 1	Homo sapiens	67-70
29215336-0	2017	Caffeine Increases Apolipoprotein A-1 and Paraoxonase-1 but not Paraoxonase-3 Protein Levels in Human-Derived Liver (HepG2) Cells.	Caffeine	0-8	paraoxonase 1	Homo sapiens	42-55
29215336-3	2017	AIMS: To investigate the dose-dependent effects of caffeine on liver apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 protein levels.	Caffeine	51-59	apolipoprotein A1	Homo sapiens	69-87
28974436-3	2017	Four small molecules (nicotine, mannitol, propranolol, caffeine) showed decreased permeability across mucin dispersions, compared to controls, and a greater effect was seen with HFDS than with PGM.	Caffeine	55-63	LOC100508689	Homo sapiens	102-107
29215336-3	2017	AIMS: To investigate the dose-dependent effects of caffeine on liver apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 protein levels.	Caffeine	51-59	paraoxonase 1	Homo sapiens	89-102
29215336-3	2017	AIMS: To investigate the dose-dependent effects of caffeine on liver apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 protein levels.	Caffeine	51-59	paraoxonase 3	Homo sapiens	107-120
29215336-8	2017	RESULTS: We observed a significant increase on apolipoprotein A-1 and paraoxonase-1 protein levels in the cells incubated with 50 microM of caffeine and a significant increase on paraoxonase-1 protein level in the cells incubated with 200 microM of caffeine.	Caffeine	140-148	apolipoprotein A1	Homo sapiens	47-65
29215336-8	2017	RESULTS: We observed a significant increase on apolipoprotein A-1 and paraoxonase-1 protein levels in the cells incubated with 50 microM of caffeine and a significant increase on paraoxonase-1 protein level in the cells incubated with 200 microM of caffeine.	Caffeine	140-148	paraoxonase 1	Homo sapiens	70-83
28935543-0	2017	The effect of acute caffeine intake on insulin sensitivity and glycemic control in people with diabetes.	Caffeine	20-28	insulin	Homo sapiens	39-46
28974436-4	2017	Permeability of propranolol and caffeine across filter-grown TR146 cells was decreased by the presence of mucin, whereas no effect was found on nicotine and mannitol.	Caffeine	32-40	LOC100508689	Homo sapiens	106-111
29230349-6	2017	Results: Acute exposure to the higher dose of caffeine increased the RRV of the SSB relative to placebo, but only when that dose was presented in the first week and only in female participants.	Caffeine	46-54	small RNA binding exonuclease protection factor La	Homo sapiens	80-83
29230349-7	2017	The liking of the caffeine-containing SSB at the higher dose was lower than the placebo at all time points.	Caffeine	18-26	small RNA binding exonuclease protection factor La	Homo sapiens	38-41
29230349-9	2017	This supports previous work suggesting that caffeine can increase desire to consume SSB.	Caffeine	44-52	small RNA binding exonuclease protection factor La	Homo sapiens	84-87
27457910-5	2017	Consistent with the involvement of IRS2 signals in caffeine-mediated synaptic plasticity, phosphorylation of Akt (Ser473) in response to LTP induction is defective in Irs2-/- mice, demonstrating that these plasticity changes are associated with downstream targets of the phosphoinositide 3-kinase (PI3K) pathway.	Caffeine	51-59	thymoma viral proto-oncogene 1	Mus musculus	109-112
29145719-2	2017	Here, we evaluated MPF activity in vitrified mouse eggs following treatment with caffeine, a known stimulator of MPF activity, and/or the proteasome inhibitor MG132.	Caffeine	81-89	mesothelin	Mus musculus	19-22
29145719-2	2017	Here, we evaluated MPF activity in vitrified mouse eggs following treatment with caffeine, a known stimulator of MPF activity, and/or the proteasome inhibitor MG132.	Caffeine	81-89	mesothelin	Mus musculus	113-116
27457910-6	2017	These findings indicate that TrkB-IRS2 signals are essential for activation of PI3K during the induction of LTP by caffeine.	Caffeine	115-123	neurotrophic receptor tyrosine kinase 2	Homo sapiens	29-33
27457910-0	2017	Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling.	Caffeine	0-8	brain derived neurotrophic factor	Homo sapiens	18-22
27457910-6	2017	These findings indicate that TrkB-IRS2 signals are essential for activation of PI3K during the induction of LTP by caffeine.	Caffeine	115-123	insulin receptor substrate 2	Homo sapiens	34-38
27457910-0	2017	Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling.	Caffeine	0-8	insulin receptor substrate 2	Homo sapiens	93-97
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	lysine acetyltransferase 2B	Homo sapiens	161-164
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	carbonic anhydrase 1	Homo sapiens	177-180
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	brain derived neurotrophic factor	Homo sapiens	251-255
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	neurotrophic receptor tyrosine kinase 2	Homo sapiens	286-290
28640361-8	2017	A further exploratory analysis of metabolic pathways revealed key roles for the urea cycle and caffeine metabolism associated with PLP and CRC risk.	Caffeine	95-103	proteolipid protein 1	Homo sapiens	131-134
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	lysine acetyltransferase 2B	Homo sapiens	341-344
28855448-8	2017	Both FANCD2 monoubiquitination and RAD51 expression were significantly inhibited by co-treatment with 200 microg/mL caffeine and 3.8 microg/mL cisplatin compared with cisplatin alone.	Caffeine	116-124	FA complementation group D2	Homo sapiens	5-11
28855448-8	2017	Both FANCD2 monoubiquitination and RAD51 expression were significantly inhibited by co-treatment with 200 microg/mL caffeine and 3.8 microg/mL cisplatin compared with cisplatin alone.	Caffeine	116-124	RAD51 recombinase	Homo sapiens	35-40
28855448-9	2017	In conclusion, caffeine enhances the anticancer effect of cisplatin by inhibiting FANCD2 monoubiquitination.	Caffeine	15-23	FA complementation group D2	Homo sapiens	82-88
28664630-0	2017	Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women.	Caffeine	42-50	sex hormone binding globulin	Homo sapiens	68-96
28664630-5	2017	The relationship between coffee and caffeine consumption and SHBG was modelled, with adjustment for covariates and stratification by body mass index (BMI) categories (&lt; or &gt;=25 kg/m2 ) and menopausal status.	Caffeine	36-44	sex hormone binding globulin	Homo sapiens	61-65
28664630-7	2017	High coffee (&gt;=3 cups/day) and caffeine (&gt;=265 mg/day) intakes were associated with a reduced risk of being in the 1st quartile of the SHBG level distribution (&lt;46.3 nmol/L) in a multivariate adjusted model (OR: 0.72 [95% CI: 0.52-1.01] and OR: 0.71 [95% CI: 0.53-0.95], respectively).	Caffeine	34-42	sex hormone binding globulin	Homo sapiens	141-145
28664630-10	2017	The association with SHBG was consistently noted with consumption of both caffeinated coffee and caffeine, but not decaffeinated coffee.	Caffeine	97-105	sex hormone binding globulin	Homo sapiens	21-25
28664630-11	2017	CONCLUSIONS: Consumption of high coffee and caffeine is associated with a reduced risk of low SHBG, an established risk marker for T2DM, which might contribute to the protective effects of coffee for type 2 diabetes.	Caffeine	44-52	sex hormone binding globulin	Homo sapiens	94-98
29164236-8	2017	LOXL1-a transcripts were upregulated in hTCF and hTMC by NMD inhibitors puromycin and caffeine (&gt;=6-fold; P &lt; 0.01) or after knockdown of NMD core factors (&gt;=2-fold; P &lt; 0.05), whereas mRNA and protein levels of LOXL1 were reduced (&lt;=0.8 fold; P &lt; 0.05).	Caffeine	86-94	lysyl oxidase like 1	Homo sapiens	0-5
28949381-8	2017	ER stress was stimulated by caffeine as demonstrated by increased levels of GRP78/Bip, CHOP and inositol-requiring enzyme 1 (IRE1)-alpha as well as many enlarged ERs detected by electron microscopy.	Caffeine	28-36	heat shock protein family A (Hsp70) member 5	Homo sapiens	76-81
28949381-8	2017	ER stress was stimulated by caffeine as demonstrated by increased levels of GRP78/Bip, CHOP and inositol-requiring enzyme 1 (IRE1)-alpha as well as many enlarged ERs detected by electron microscopy.	Caffeine	28-36	heat shock protein family A (Hsp70) member 5	Homo sapiens	82-85
28949381-8	2017	ER stress was stimulated by caffeine as demonstrated by increased levels of GRP78/Bip, CHOP and inositol-requiring enzyme 1 (IRE1)-alpha as well as many enlarged ERs detected by electron microscopy.	Caffeine	28-36	DNA damage inducible transcript 3	Homo sapiens	87-91
28949381-8	2017	ER stress was stimulated by caffeine as demonstrated by increased levels of GRP78/Bip, CHOP and inositol-requiring enzyme 1 (IRE1)-alpha as well as many enlarged ERs detected by electron microscopy.	Caffeine	28-36	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	96-136
28949381-9	2017	Caffeine induced autophagy as shown by increased p62 and LC3II accumulation and the number of GFP/RFP-LC3 puncta and autophagosomes/autolysosomes.	Caffeine	0-8	nucleoporin 62	Homo sapiens	49-52
28949381-9	2017	Caffeine induced autophagy as shown by increased p62 and LC3II accumulation and the number of GFP/RFP-LC3 puncta and autophagosomes/autolysosomes.	Caffeine	0-8	tripartite motif containing 27	Homo sapiens	98-101
28949381-11	2017	In conclusion, our study showed that the caffeine-enhanced autophagic flux in HSCs was stimulated by ER stress via the IRE1-alpha signaling pathway, which further weakened HSC viability via the induction of apoptosis.	Caffeine	41-49	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	119-129
27444711-6	2017	Combined exposure to caffeine and catechins significantly upregulated mRNA and protein expression levels of lipases while downregulating FAS mRNA expression and protein expression of peroxisome proliferator-activated receptor gamma2.	Caffeine	21-29	fatty acid synthase	Mus musculus	137-140
28836403-7	2017	RESULTS: Conditioned medium of MSCs treated with caffeine significantly enhanced phagocytosis and simultaneously regressed expression of reactive oxygen species (ROS) and nitric oxide (NO) as well as IL-12 by macrophages compared to the supernatants of MSCs alone.	Caffeine	49-57	interleukin 12B	Rattus norvegicus	200-205
28836403-8	2017	The conditioned medium of MSCs pulsed with caffeine at low to moderate concentrations preserved the neutral red uptake by macrophages and elevated IL-10 secretion by macrophages.	Caffeine	43-51	interleukin 10	Rattus norvegicus	147-152
28530573-6	2017	F05 not only reduced human-perceived bitterness, but also effectively suppressed the intracellular Ca2+ response induced by caffeine in the hTAS2R43 and hTAS2R46 human bitter-taste receptor-expressing cells.	Caffeine	124-132	taste 2 receptor member 43	Homo sapiens	140-148
29254178-2	2017	Caffeine-induced serine/arginine-rich splicing factor 2, SRSF2, and SRSF3 are required for the alternative splicing of a subset of cancer-associated genes.	Caffeine	0-8	serine and arginine rich splicing factor 2	Homo sapiens	57-62
29254178-2	2017	Caffeine-induced serine/arginine-rich splicing factor 2, SRSF2, and SRSF3 are required for the alternative splicing of a subset of cancer-associated genes.	Caffeine	0-8	serine and arginine rich splicing factor 3	Homo sapiens	68-73
29254178-8	2017	Our results provide an insight that theophylline as well as caffeine could be repurposed as antitumor leading compounds via the downregulation of splicing factor SRSF3 and its target genes.	Caffeine	60-68	serine and arginine rich splicing factor 3	Homo sapiens	162-167
27444711-6	2017	Combined exposure to caffeine and catechins significantly upregulated mRNA and protein expression levels of lipases while downregulating FAS mRNA expression and protein expression of peroxisome proliferator-activated receptor gamma2.	Caffeine	21-29	peroxisome proliferator activated receptor gamma	Mus musculus	183-232
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Caffeine	83-91	CD38 molecule	Homo sapiens	239-243
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Caffeine	83-91	ryanodine receptor 2	Homo sapiens	348-373
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Caffeine	83-91	ryanodine receptor 2	Homo sapiens	4-33
28753475-5	2017	Spontaneous activity of Ca2+ sparks through ryanodine-sensitive channels (RyR) was unchanged, whereas the RyR-mediated Ca2+-release activated by caffeine was shorter in PS1dE9 SMC when compared with control.	Caffeine	145-153	ryanodine receptor 1, skeletal muscle	Mus musculus	106-109
29104955-11	2017	MLO-Y4 CM and WNT3a increased caffeine-induced Ca2+ release from the sarcoplasmic reticulum (SR) of C2C12 myotubes and the expression of genes directly associated with intracellular Ca2+ signaling and homeostasis.	Caffeine	30-38	wingless-type MMTV integration site family, member 3A	Mus musculus	14-19
28753475-5	2017	Spontaneous activity of Ca2+ sparks through ryanodine-sensitive channels (RyR) was unchanged, whereas the RyR-mediated Ca2+-release activated by caffeine was shorter in PS1dE9 SMC when compared with control.	Caffeine	145-153	presenilin 1	Mus musculus	169-175
28753475-6	2017	Moreover, PS1dE9 mutation decreased the caffeine-activated capacitive Ca2+ entry, and inhibitors of SERCA pumps reversed the effects of PS1dE9 on Ca2+ signals.	Caffeine	40-48	presenilin 1	Mus musculus	10-16
28731505-13	2017	Furthermore, exposure to 8-pCPT-AM significantly slows the initial rate of [Ca2+ ]i rise induced by the RyR activator caffeine without significantly affecting the caffeine-induced Ca2+ transient amplitude, a measure of Ca2+ store content.	Caffeine	118-126	ryanodine receptor 2	Rattus norvegicus	104-107
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	18-26	interleukin 1 beta	Rattus norvegicus	187-195
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	tumor necrosis factor	Rattus norvegicus	177-185
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 1 beta	Rattus norvegicus	187-195
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 18	Rattus norvegicus	201-206
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	tumor necrosis factor	Rattus norvegicus	177-185
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 1 beta	Rattus norvegicus	187-195
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 18	Rattus norvegicus	201-206
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	tumor necrosis factor	Rattus norvegicus	177-185
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 1 beta	Rattus norvegicus	187-195
28643232-7	2017	Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine.	Caffeine	110-118	interleukin 18	Rattus norvegicus	201-206
28912486-6	2017	Interestingly, caffeine treatment inhibited the formation of Rad51 or Rad54 foci, but not the formation of gammaH2AX and Exo1 foci, which led to incomplete HR in ssDNA, thus increasing DNA damage sensitivity.	Caffeine	15-23	RAD51 recombinase	Mus musculus	61-66
28912486-6	2017	Interestingly, caffeine treatment inhibited the formation of Rad51 or Rad54 foci, but not the formation of gammaH2AX and Exo1 foci, which led to incomplete HR in ssDNA, thus increasing DNA damage sensitivity.	Caffeine	15-23	RAD54 like (S. cerevisiae)	Mus musculus	70-75
28677810-0	2017	Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway.	Caffeine	0-8	caspase 9	Homo sapiens	85-94
28301304-8	2017	Protection and treatment with caffeine ameliorated the oxidative stress and the changes in acetylcholinesterase and Na+/K+-ATPase activities induced by rotenone in the midbrain and the striatum.	Caffeine	30-38	acetylcholinesterase	Rattus norvegicus	91-111
28466533-0	2017	Synergic effects of sugar and caffeine on insulin-mediated metabolomic alterations after an acute consumption of soft drinks.	Caffeine	30-38	insulin	Homo sapiens	42-49
28466533-2	2017	Furthermore, there is also growing evidence that caffeine may play an important role in the regulation of insulin release and the appearance of related metabolic impairments.	Caffeine	49-57	insulin	Homo sapiens	106-113
28466533-6	2017	However, the most significant findings were observed after the co-ingestion of caffeine, which could be indicative of a synergic effect of this psychostimulant on insulin-mediated perturbations.	Caffeine	79-87	insulin	Homo sapiens	163-170
28465162-7	2017	The results revealed that caffeine, caffeic acid and their various combinations exhibited inhibitory effect on activities of AChE, MAO, E-NTPase and E-NTDase, but stimulatory effect on Na+/K+ ATPase activity.	Caffeine	26-34	acetylcholinesterase	Rattus norvegicus	125-129
28465162-7	2017	The results revealed that caffeine, caffeic acid and their various combinations exhibited inhibitory effect on activities of AChE, MAO, E-NTPase and E-NTDase, but stimulatory effect on Na+/K+ ATPase activity.	Caffeine	26-34	monoamine oxidase A	Rattus norvegicus	131-134
28399119-0	2017	Caffeine ameliorates hyperoxia-induced lung injury by protecting GCH1 function in neonatal rat pups.	Caffeine	0-8	GTP cyclohydrolase 1	Rattus norvegicus	65-69
28399119-6	2017	Caffeine also increased the levels of phosphorylated endothelial nitric oxide synthase (eNOS) at serine1177, total and serine51 phosphorylated GTP cyclohydrolase 1 (GCH1), and BH4 levels, with improved alveolar structure and angiogenesis in hyperoxia-exposed lungs.	Caffeine	0-8	GTP cyclohydrolase 1	Rattus norvegicus	143-163
28399119-6	2017	Caffeine also increased the levels of phosphorylated endothelial nitric oxide synthase (eNOS) at serine1177, total and serine51 phosphorylated GTP cyclohydrolase 1 (GCH1), and BH4 levels, with improved alveolar structure and angiogenesis in hyperoxia-exposed lungs.	Caffeine	0-8	GTP cyclohydrolase 1	Rattus norvegicus	165-169
28399119-7	2017	Reduced GCH1 levels in hyperoxia were due, in part, to increased degradation by the ubiquitin-proteasome system.ConclusionOur data support the notion that early caffeine treatment can protect immature lungs from hyperoxia-induced damage by improving eNOS activity through increased BH4 bioavailability.	Caffeine	161-169	GTP cyclohydrolase 1	Rattus norvegicus	8-12
28677810-0	2017	Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway.	Caffeine	0-8	caspase 3	Homo sapiens	95-104
28677810-7	2017	The results indicated that caffeine treatment significantly suppressed GC cell growth and viability and induced apoptosis by activating the caspase-9/-3 pathway.	Caffeine	27-35	caspase 9	Homo sapiens	140-149
28677810-8	2017	Furthermore, the anticancer effects of caffeine appeared to be sustained, as the caspase-9/-3 pathway remained active following caffeine withdrawal.	Caffeine	39-47	caspase 9	Homo sapiens	81-90
28677810-8	2017	Furthermore, the anticancer effects of caffeine appeared to be sustained, as the caspase-9/-3 pathway remained active following caffeine withdrawal.	Caffeine	128-136	caspase 9	Homo sapiens	81-90
28677810-9	2017	In conclusion, caffeine may function as a sustained anticancer agent by activating the caspase-9/-3 pathway, which indicates that it may be useful as a therapeutic candidate in gastric cancer.	Caffeine	15-23	caspase 9	Homo sapiens	87-96
29072170-2	2017	BACKGROUND AND AIMS: The possible effect of caffeine as an enhancer of cognitive performance, particularly that on abstract reasoning, has never been studied in an epidemiological setting, especially in relation to -163C&gt;A polymorphism of CYP1A2 gene, largely controlling caffeine metabolism.	Caffeine	44-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	242-248
29044427-6	2017	Subsequent treatment of bull sperm with either the calcium chelator ethylene glycol tetraacetic acid; mibefradil, a specific blocker of CatSper channels in human sperm; or CATSPER1 antibody all significantly inhibited caffeine-induced hyperactivation and the rheotactic response, supporting the concept that the calcium influx occurs via CatSper channels.	Caffeine	218-226	cation channel sperm associated 1	Homo sapiens	172-180
28672269-7	2017	Caffeine- and ryanodine-induced intracellular Ca2+ mobilization and BKCa channel beta1 subunit expression were increased in arteries from OZR.	Caffeine	0-8	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	68-72
28672269-7	2017	Caffeine- and ryanodine-induced intracellular Ca2+ mobilization and BKCa channel beta1 subunit expression were increased in arteries from OZR.	Caffeine	0-8	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	81-86
29072170-12	2017	CONCLUSIONS: In general population, a positive association between caffeine intake and abstract reasoning exists in the CC homozygous of the -163C&gt;A polymorphism of CYP1A2 gene.	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	168-174
28707282-6	2017	Using this assay, we show that rapamycin derivatives behave similarly to rapamycin, while caffeine and the ATP competitive inhibitors Torin 1 and GSK2126458 are mTORC1 inhibitors in yeast that act independently of Fpr1.	Caffeine	90-98	CREB regulated transcription coactivator 1	Mus musculus	161-167
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Caffeine	24-32	adenosine A2a receptor	Homo sapiens	76-98
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Caffeine	24-32	adenosine A2a receptor	Homo sapiens	100-104
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Caffeine	24-32	adenosine A2a receptor	Homo sapiens	164-168
28420694-5	2017	At the hyperoxic phase, caffeine reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by combined caffeine and A2AR-knockout treatment.	Caffeine	151-159	adenosine A2a receptor	Homo sapiens	100-104
28420694-6	2017	At the hypoxic phase, caffeine reduced microglial activation and enhanced tip cell formation by A2AR-dependent and -independent mechanisms, as combined caffeine and A2AR knockout produced additive and nearly full protection against OIR.	Caffeine	22-30	adenosine A2a receptor	Homo sapiens	96-100
28387457-10	2017	We find that RyR1 channels from Tric-a KO mice respond normally to cytosolic Ca2+ , ATP, adenine, caffeine and to luminal Ca2+ .	Caffeine	98-106	ryanodine receptor 1, skeletal muscle	Mus musculus	13-17
28696284-6	2017	In HGT-1 cells, various bitter compounds as well as caffeine stimulated proton secretion, whereby the caffeine-evoked effect was (i) shown to depend on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a known inhibitor of caffeine"s bitter taste.	Caffeine	102-110	taste 2 receptor member 43	Homo sapiens	181-188
28696284-6	2017	In HGT-1 cells, various bitter compounds as well as caffeine stimulated proton secretion, whereby the caffeine-evoked effect was (i) shown to depend on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a known inhibitor of caffeine"s bitter taste.	Caffeine	102-110	taste 2 receptor member 43	Homo sapiens	181-188
28106278-8	2017	Moreover, we have demonstrated that caffeine is able to prevent outer BRB damage by inhibiting apoptotic cell death induced by hyperglycemic/hypoxic insult since it downregulates the proapoptotic Bax and upregulates the anti-apoptotic Bcl-2 genes.	Caffeine	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	196-199
28106278-8	2017	Moreover, we have demonstrated that caffeine is able to prevent outer BRB damage by inhibiting apoptotic cell death induced by hyperglycemic/hypoxic insult since it downregulates the proapoptotic Bax and upregulates the anti-apoptotic Bcl-2 genes.	Caffeine	36-44	BCL2 apoptosis regulator	Homo sapiens	235-240
28387457-3	2017	We find that RyR1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cytosolic Ca2+ , ATP, caffeine and luminal Ca2+ .	Caffeine	148-156	ryanodine receptor 1, skeletal muscle	Mus musculus	13-17
28387457-10	2017	We find that RyR1 channels from Tric-a KO mice respond normally to cytosolic Ca2+ , ATP, adenine, caffeine and to luminal Ca2+ .	Caffeine	98-106	transmembrane protein 38A	Mus musculus	32-38
28387457-3	2017	We find that RyR1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cytosolic Ca2+ , ATP, caffeine and luminal Ca2+ .	Caffeine	148-156	transmembrane protein 38A	Mus musculus	23-29
28696986-6	2017	Caffeine is a known ergogenic aid that could be dosed at 3 mg kg to maximize benefits of mental alertness while limiting potential side effects.	Caffeine	0-8	activation induced cytidine deaminase	Homo sapiens	30-33
28213294-7	2017	Administration of caffeine in P0.5 CD1 wildtype neonates resulted in an increase in tidal volume, minute ventilation, and minute ventilation normalized to oxygen consumption as well as a decrease in periodic instability.	Caffeine	18-26	CD1 antigen complex	Mus musculus	35-38
28677085-10	2017	Results revealed that Tan1p overexpression confers resistance to GCD7 GCN2, gcd7-201 gcn2 , GCD7 gcn2  growth defect under ethanol, H2O2 and caffeine stress.	Caffeine	141-149	putative tRNA acetyltransferase	Saccharomyces cerevisiae S288C	22-27
28430840-4	2017	Phosphorylation of Med1 was abrogated by either caffeine or wortmannin treatment, suggesting that Med1 is phosphorylated through the DNA damage checkpoint pathway.	Caffeine	48-56	mediator complex subunit 1	Homo sapiens	19-23
28569556-10	2017	Caffeine only inhibited the mTOR pathway in MCF-7 cells.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	28-32
28355205-0	2017	Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study.	Caffeine	29-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
28654087-0	2017	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	31-34
28654087-1	2017	Caffeine, an antagonist of the adenosine receptor A1R, is used as a dietary supplement to reduce body weight, although the underlying mechanism is unclear.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	50-53
26788968-7	2017	Coffee component(s) responsible for the activation of HIF-1alpha was not major constituents such as caffeine, caffeic acid, chlorogenic acid, and trigonelline, but was found to emerge during roasting process.	Caffeine	100-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
28430840-4	2017	Phosphorylation of Med1 was abrogated by either caffeine or wortmannin treatment, suggesting that Med1 is phosphorylated through the DNA damage checkpoint pathway.	Caffeine	48-56	mediator complex subunit 1	Homo sapiens	98-102
28322926-0	2017	Caffeine inhibition of GLUT1 is dependent on the activation state of the transporter.	Caffeine	0-8	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	23-28
28177708-2	2017	However, recent in vitro findings have suggested that caffeine may block skeletal muscle anabolic signaling through AMP-activated protein kinase (AMPK)-mediated inhibition of mechanistic target of rapamycin (mTOR) signaling pathway.	Caffeine	54-62	mechanistic target of rapamycin kinase	Mus musculus	175-206
28177708-2	2017	However, recent in vitro findings have suggested that caffeine may block skeletal muscle anabolic signaling through AMP-activated protein kinase (AMPK)-mediated inhibition of mechanistic target of rapamycin (mTOR) signaling pathway.	Caffeine	54-62	mechanistic target of rapamycin kinase	Mus musculus	208-212
28177708-4	2017	The primary purpose of this study was to assess the effect of caffeine on in vivo AMPK and mTOR pathway signaling, protein synthesis, and muscle growth.	Caffeine	62-70	mechanistic target of rapamycin kinase	Mus musculus	91-95
28322926-8	2017	Two epithelial cell lines, HCLE and HK2, have both higher concentrations of GLUT1 and increased basal 2DG uptake (3-4 fold) compared to L929 cells, and subsequently display greater maximal inhibition by caffeine (66-70%).	Caffeine	203-211	hexokinase 2	Mus musculus	36-39
28322926-8	2017	Two epithelial cell lines, HCLE and HK2, have both higher concentrations of GLUT1 and increased basal 2DG uptake (3-4 fold) compared to L929 cells, and subsequently display greater maximal inhibition by caffeine (66-70%).	Caffeine	203-211	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	76-81
28322926-10	2017	These data indicate that the inhibition of caffeine is dependent on the activity state of GLUT1, not merely on the concentration.	Caffeine	43-51	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	90-95
28524102-6	2017	Moreover, both RBS (1000 mg/kg) and doxepin hydrochloride (histamine H1 receptor antagonist, 30 mg/kg) counteracted a caffeine-induced sleep disturbance in mice.	Caffeine	118-126	histamine receptor H1	Mus musculus	59-80
27915051-2	2017	This review makes the point that caffeine is - in low doses - an antagonist of adenosine acting at A1, A2A and A2B receptors.	Caffeine	33-41	immunoglobulin kappa variable 2D-29	Homo sapiens	103-106
28088487-6	2017	Lastly, we discussed the translational potential as well therapeutic advantage of adenosine receptor- and caffeine-based therapy for ROR and possibly other proliferative retinopathy.	Caffeine	106-114	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	133-136
28277162-4	2017	Pretreatment with caffeine (100 nM and 10 muM) sensitized SH-SY5Y cells to doxorubicin-induced toxicity and increased apoptosis and sensitized PC3 cells to gemcitabine-induced toxicity.	Caffeine	18-26	latexin	Homo sapiens	42-45
28277162-5	2017	Pretreatment with 10 muM caffeine decreased total cell reactive oxygen species (ROS) production but increased mitochondrial ROS production.	Caffeine	25-33	latexin	Homo sapiens	21-24
28277162-6	2017	In contrast, caffeine (10 nM and 10 muM) protected cells against gemcitabine-induced toxicity and apoptosis.	Caffeine	13-21	latexin	Homo sapiens	36-39
28277162-7	2017	Similarly, 1 muM and 10 muM caffeine protected cells against paclitaxel-induced toxicity and mitochondrial ROS production.	Caffeine	28-36	latexin	Homo sapiens	24-27
28412215-11	2017	On the basis of CUMS model, 21 days treatment with ginsenoside Rb1 not only had effective interactions with caffeine (5mg/kg, i.p.	Caffeine	108-116	RB transcriptional corepressor 1	Rattus norvegicus	63-66
28422746-0	2017	Integrating nanohybrid membranes of reduced graphene oxide: chitosan: silica sol gel with fiber optic SPR for caffeine detection.	Caffeine	110-118	sepiapterin reductase	Homo sapiens	102-105
28515832-1	2017	Dietary supplements are widely used to enhance sport performance and the combination of carbohydrate and caffeine (CHO+CAF) has yielded particularly high performance gains.	Caffeine	105-113	lysine acetyltransferase 2B	Homo sapiens	119-122
28222393-2	2017	In the present study we evaluated the effects of high-intensity interval training (HIIT) associated with caffeine intake on acetylcholinesterase (AChE) and Ca2+ATPase activity and glycogen levels in the muscles of rats were evaluated.	Caffeine	105-113	acetylcholinesterase	Rattus norvegicus	146-150
28213471-10	2017	Caffeine also attenuated the hyperoxia-induced activation of cyclooxygenase-2 and markers of apoptosis.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-77
28188930-11	2017	miR-135a overexpression reduced spontaneous beating frequency of neonatal rat ventricular myocytes by 63% (P &lt;.001) while slowing decay (by 56%, P &lt;.05) of caffeine-induced Ca2+ transients.	Caffeine	162-170	microRNA 135a	Rattus norvegicus	0-8
27363424-0	2017	Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-21
28350110-10	2017	IFN-gamma treatment decreased cell viability and increased oxidative stress in glutamine-free medium, despite caffeine supplementation.	Caffeine	110-118	interferon gamma	Homo sapiens	0-9
28350110-11	2017	Although caffeine exerted a protective effect against MeHg-induced toxicity with glutamate transmission, under co-stimulation with glutamine and IFN-gamma, caffeine decreased the MeHg-induced average oxidative stress only by half.	Caffeine	156-164	interferon gamma	Homo sapiens	145-154
28350110-12	2017	Thereby, our data indicate that the IFN-gamma stimulation of mercury-exposed dopaminergic neurons in neuroinflammatory diseases may diminish the neuroprotective effects of caffeine.	Caffeine	172-180	interferon gamma	Homo sapiens	36-45
27363424-1	2017	BACKGROUND: Proposed differences in caffeine metabolism due to the CYP1A2*1F polymorphism have been linked to variations in cardiovascular disease risk.	Caffeine	36-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	67-73
27363424-2	2017	AIMS: We examined the influence of a CYP1A2*1F polymorphism on post-exercise heart rate variability (HRV) in response to caffeine intake.	Caffeine	121-129	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
27363424-9	2017	CONCLUSIONS: Rate of RMSSD recovery was the only variable influenced by the CYP1A2*IF polymorphism during post-exercise in response to caffeine intake.	Caffeine	135-143	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
28062599-10	2017	A2AR occupancy was studied with caffeine blockade.	Caffeine	32-40	adenosine A2a receptor	Homo sapiens	0-4
28375845-2	2017	This study was taken to understand the direct effect of ACTH action on thermogenin gene expression and possible relation with alpha receptors and caffeine with this hormone.	Caffeine	146-154	pro-opiomelanocortin-alpha	Mus musculus	56-60
28375845-2	2017	This study was taken to understand the direct effect of ACTH action on thermogenin gene expression and possible relation with alpha receptors and caffeine with this hormone.	Caffeine	146-154	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	71-82
28375845-13	2017	In the presence of caffeine, ACTH increases cAMP generation and UCP1 gene expression more than twofold.	Caffeine	19-27	pro-opiomelanocortin-alpha	Mus musculus	29-33
28375845-13	2017	In the presence of caffeine, ACTH increases cAMP generation and UCP1 gene expression more than twofold.	Caffeine	19-27	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	64-68
28375845-16	2017	Further stimulation of cAMP generation and thermogenin gene expression is possible with ACTH in conjugation with caffeine and RO 20-1724.	Caffeine	113-121	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	43-54
28503530-7	2017	When compared the changes between groups (postvalues minus prevalues), there was lower glucose in CAF group when compared to CHO group (CAF= 5.0+-10.4 vs. CHO=27.8+-20 vs. P=15.1+-14, P=0.031) and higher IL-6 levels (CAF=11.9+-9.2 vs. CHO=-2.4+-1.7 vs. P=4.3+- 11.7, P=0.017).	Caffeine	98-101	interleukin 6	Homo sapiens	204-208
28141790-6	2017	RESULTS: Caffeine downregulated expression of type I and type III TGF-beta receptors, and Smad2; and potentiated TGF-beta signaling in vitro.	Caffeine	9-17	SMAD family member 2	Mus musculus	90-95
28141790-7	2017	In vivo, caffeine administration normalized body mass under hyperoxic conditions, and normalized Smad2 phosphorylation detected in lung homogenates; however, caffeine administration neither improved nor worsened lung structure in hyperoxia-exposed mice, in which postnatal lung maturation was blunted.	Caffeine	9-17	SMAD family member 2	Mus musculus	97-102
28409659-6	2017	Multivariable linear regression and Linear Mixed Models (LMMs) were used to understand the effect of caffeine consumption on CD4 count and HIV viral load.	Caffeine	101-109	CD4 molecule	Homo sapiens	125-128
28409659-10	2017	Multivariable linear regressions after adjustment for covariates showed significant association between caffeine consumption and higher CD4 count (beta = 1.532, p = 0.049) and lower HIV viral load (beta = -1.067, p = 0.048).	Caffeine	104-112	CD4 molecule	Homo sapiens	136-139
28409659-11	2017	LMM after adjustment for covariates showed that the relationship between caffeine and CD4 count (beta = 1.720, p = 0.042) and HIV viral load (beta = -1.389, p = 0.033) continued over time in a dose-response manner.	Caffeine	73-81	CD4 molecule	Homo sapiens	86-89
28409659-12	2017	Higher caffeine consumption was associated with higher CD4 cell counts and lower HIV viral loads indicating beneficial effects on HIV disease progression.	Caffeine	7-15	CD4 molecule	Homo sapiens	55-58
28409659-13	2017	Further studies examining biochemical effects of caffeine on CD4 cell counts and viral replication need to be done in the future.	Caffeine	49-57	CD4 molecule	Homo sapiens	61-64
28320839-0	2017	Sleep Deprivation and Caffeine Treatment Potentiate Photic Resetting of the Master Circadian Clock in a Diurnal Rodent.	Caffeine	22-30	clock circadian regulator	Rattus norvegicus	93-98
28320167-8	2017	These data indicate that the deleterious interaction between caffeine and creatine with respect to rate of progression of PD is influenced by GRIN2A genotype.	Caffeine	61-69	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	142-148
28235548-2	2017	Caffeine exacerbates cannabinoid CB1 receptor (CB1R)-induced memory deficits through an adenosine A1 receptor-mediated mechanism.	Caffeine	0-8	cannabinoid receptor 1 (brain)	Mus musculus	33-36
28235548-2	2017	Caffeine exacerbates cannabinoid CB1 receptor (CB1R)-induced memory deficits through an adenosine A1 receptor-mediated mechanism.	Caffeine	0-8	cannabinoid receptor 1 (brain)	Mus musculus	47-51
28320839-10	2017	Caffeine treatment in midnight triggered c-Fos expression in dorsal SCN.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
28320839-11	2017	Both sleep deprivation and caffeine treatment potentiated light-induced c-Fos expression in calbindin-containing cells of the ventral SCN in early and late night.	Caffeine	27-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
28320839-11	2017	Both sleep deprivation and caffeine treatment potentiated light-induced c-Fos expression in calbindin-containing cells of the ventral SCN in early and late night.	Caffeine	27-35	calbindin 1	Rattus norvegicus	92-101
28320839-12	2017	These findings indicate that, in contrast to nocturnal rodents, behavioral arousal induced either by sleep deprivation or caffeine during the sleeping period potentiates light resetting of the master circadian clock in diurnal rodents, and activation of calbindin-containing suprachiasmatic cells may be involved in this effect.SIGNIFICANCE STATEMENT Arousing stimuli have the ability to regulate circadian rhythms in mammals.	Caffeine	122-130	clock circadian regulator	Rattus norvegicus	210-215
28320839-12	2017	These findings indicate that, in contrast to nocturnal rodents, behavioral arousal induced either by sleep deprivation or caffeine during the sleeping period potentiates light resetting of the master circadian clock in diurnal rodents, and activation of calbindin-containing suprachiasmatic cells may be involved in this effect.SIGNIFICANCE STATEMENT Arousing stimuli have the ability to regulate circadian rhythms in mammals.	Caffeine	122-130	calbindin 1	Rattus norvegicus	254-263
28216052-0	2017	Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose.	Caffeine	77-85	ETS transcription factor ERG	Homo sapiens	18-22
28216052-3	2017	Caffeine was also found to be a hERG channel blocker with an IC50 of 5.04mM (n=5).	Caffeine	0-8	ETS transcription factor ERG	Homo sapiens	32-36
28216052-4	2017	Although these two findings likely link caffeine overdose death with hERG channel blockade, the amount of caffeine consumption needed to reach the IC50 is very high.	Caffeine	40-48	ETS transcription factor ERG	Homo sapiens	69-73
28216052-5	2017	Further study demonstrated that addition another hERG blocker could lower the consumption of caffeine significantly, no matter whether two hERG blockers share the same binding sites.	Caffeine	93-101	ETS transcription factor ERG	Homo sapiens	49-53
28216052-6	2017	Our data does not rule out other possibility, however, it suggests that there is a potential causal relationship between caffeine overdose death with hERG channel and the interaction among these hERG blockers.	Caffeine	121-129	ETS transcription factor ERG	Homo sapiens	150-154
28216052-6	2017	Our data does not rule out other possibility, however, it suggests that there is a potential causal relationship between caffeine overdose death with hERG channel and the interaction among these hERG blockers.	Caffeine	121-129	ETS transcription factor ERG	Homo sapiens	195-199
28403410-11	2017	HEK293 functional assays demonstrated an increased sensitivity of RyR1 channels containing the p.R2336H, p.R2355W, p.E3104K, p.G3990V and p.V4849I compared with wild type, but cells expressing p.D3986E had a similar caffeine sensitivity to cells expressing wild type RyR1.	Caffeine	216-224	ryanodine receptor 1	Homo sapiens	66-70
28091956-3	2017	With reports of the potential cognitive enhancing properties of caffeine, we sought to investigate if caffeine can influence the anticholinesterase and antioxidant properties of donepezil-a selective acetylcholinesterase (AChE) inhibitor used in the management of Alzheimer"s disease (AD).	Caffeine	102-110	acetylcholinesterase	Rattus norvegicus	222-226
28634643-6	2017	Caffeine treatment significantly reduced mTORC1 signaling, total protein synthesis and myotube diameter in a CaMKKbeta/AMPK-dependent manner.	Caffeine	0-8	CREB regulated transcription coactivator 1	Mus musculus	41-47
28091956-4	2017	In vitro, we investigated the effect of donepezil (DON), caffeine (CAF) and their various combinations on the activity of AChE in rat brain homogenate, as well as determined their antioxidant properties.	Caffeine	57-65	acetylcholinesterase	Rattus norvegicus	122-126
28091956-4	2017	In vitro, we investigated the effect of donepezil (DON), caffeine (CAF) and their various combinations on the activity of AChE in rat brain homogenate, as well as determined their antioxidant properties.	Caffeine	67-70	acetylcholinesterase	Rattus norvegicus	122-126
28091956-9	2017	However, co-administration of either 50 or 100 mg/kg CAF with DON lead to higher AChE activity compared to both control and DON groups.	Caffeine	53-56	acetylcholinesterase	Rattus norvegicus	81-85
28287486-2	2017	The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine.	Caffeine	167-175	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	84-90
28330503-0	2017	Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts.	Caffeine	0-8	cellular communication network factor 2	Homo sapiens	56-60
28330503-5	2017	The current study addressed the impact of glucocorticoids on the regulation of CTGF in the presence of caffeine using human lung epithelial and fibroblast cells.	Caffeine	103-111	cellular communication network factor 2	Homo sapiens	79-83
28330503-11	2017	Of note, 24 h exposure to caffeine alone significantly suppressed basal expression of CTGF mRNA and protein in IMR-90 cells.	Caffeine	26-34	cellular communication network factor 2	Homo sapiens	86-90
28330503-12	2017	Caffeine-induced reduction of CTGF mRNA expression seemed to be independent of cAMP levels, adenylyl cyclase activation, or PDE-4 inhibition.	Caffeine	0-8	cellular communication network factor 2	Homo sapiens	30-34
28330503-13	2017	While dexamethasone or caffeine treatment did not affect TGF-beta1 mRNA in H441 cells, increased expression of TGF-beta2 and TGF-beta3 mRNA was detected upon exposure to dexamethasone or dexamethasone and caffeine, respectively.	Caffeine	205-213	transforming growth factor beta 2	Homo sapiens	111-120
28330503-13	2017	While dexamethasone or caffeine treatment did not affect TGF-beta1 mRNA in H441 cells, increased expression of TGF-beta2 and TGF-beta3 mRNA was detected upon exposure to dexamethasone or dexamethasone and caffeine, respectively.	Caffeine	205-213	transforming growth factor beta 3	Homo sapiens	125-134
28330503-14	2017	Moreover, caffeine increased TNF-alpha mRNA in H441 cells (6.5 +- 2.2-fold, p &lt; 0.05) which has been described as potent inhibitor of CTGF expression.	Caffeine	10-18	tumor necrosis factor	Homo sapiens	29-38
28330503-14	2017	Moreover, caffeine increased TNF-alpha mRNA in H441 cells (6.5 +- 2.2-fold, p &lt; 0.05) which has been described as potent inhibitor of CTGF expression.	Caffeine	10-18	cellular communication network factor 2	Homo sapiens	137-141
28330503-16	2017	Simultaneous treatment with caffeine may attenuate glucocorticoid-induced expression of CTGF, thereby promoting restoration of lung homeostasis.	Caffeine	28-36	cellular communication network factor 2	Homo sapiens	88-92
28473062-11	2017	Western blot assays showed decreased expression levels of transforming growth factor-beta, connective tissue growth factor, alpha-smooth muscle actin, and collagen 1 in the coffee- and caffeine-treated BDL groups.	Caffeine	185-193	actin gamma 2, smooth muscle	Rattus norvegicus	124-165
28032667-2	2017	We previously showed that caffeine, a nonselective adenosine receptor antagonist, delays the appearance of striatal damage resulting from expression of full-length mutant ataxin-3.	Caffeine	26-34	ataxin 3	Mus musculus	171-179
28266613-7	2017	Caffeine, one identified NMNAT2 positive-modulator, when systemically administered restored NMNAT2 expression in rTg4510 tauopathy mice to normal levels.	Caffeine	0-8	nicotinamide nucleotide adenylyltransferase 2	Mus musculus	25-31
28266613-7	2017	Caffeine, one identified NMNAT2 positive-modulator, when systemically administered restored NMNAT2 expression in rTg4510 tauopathy mice to normal levels.	Caffeine	0-8	nicotinamide nucleotide adenylyltransferase 2	Mus musculus	92-98
27485995-0	2017	Hepatoprotective Effect of Low Doses of Caffeine on CCl4-Induced Liver Damage in Rats.	Caffeine	40-48	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
27485995-3	2017	The aim of this study was to evaluate the hepatoprotective effect of low doses of caffeine on carbon tetrachloride (CCl4)-treated rats.	Caffeine	82-90	C-C motif chemokine ligand 4	Rattus norvegicus	116-120
27485995-4	2017	Low doses of caffeine (CAFF) 5 and 10 mg/kg (CAFF5 and CAFF10) were evaluated in chronic liver damage induced by CCl4 (0.75 mL/kg) in rats.	Caffeine	13-21	C-C motif chemokine ligand 4	Rattus norvegicus	113-117
27485995-8	2017	Moreover, CAFF prevented CCl4-induced prolongation in pentobarbital sleeping time and a decrease of liver fibrosis and cell death.	Caffeine	10-14	C-C motif chemokine ligand 4	Rattus norvegicus	25-29
27485995-9	2017	Our results demonstrated that low doses of CAFF exert a hepatoprotective effect against CCl4 -induced liver damage in rats.	Caffeine	43-47	C-C motif chemokine ligand 4	Rattus norvegicus	88-92
28257435-5	2017	Caffeine is both an adenosine receptor antagonist and a phosphatidylinositol-3-kinase, p110delta (PI3Kdelta) inhibitor and, at physiologically relevant levels, significantly reversed suppression.	Caffeine	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	56-96
28257435-5	2017	Caffeine is both an adenosine receptor antagonist and a phosphatidylinositol-3-kinase, p110delta (PI3Kdelta) inhibitor and, at physiologically relevant levels, significantly reversed suppression.	Caffeine	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	98-107
28257435-7	2017	Furthermore, addition of caffeine or Idelalisib to activated CLL cells significantly inhibited phosphorylation of AKT, a downstream kinase of PI3K, but did not affect CLL viability.	Caffeine	25-33	AKT serine/threonine kinase 1	Homo sapiens	114-117
28257435-8	2017	These results suggest that caffeine, in common with Idelalisib, reduces the immuno-suppressive activity of activated CLL cells by inhibiting PI3Kdelta.	Caffeine	27-35	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	141-150
28253085-0	2017	Water pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test.	Caffeine	129-137	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	96-102
26860412-0	2017	Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	101-123
26860412-1	2017	Caffeine prophylactically prevents mood and memory impairments through adenosine A2A receptor (A2AR) antagonism.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	71-93
26860412-1	2017	Caffeine prophylactically prevents mood and memory impairments through adenosine A2A receptor (A2AR) antagonism.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	95-99
26860412-9	2017	Furthermore, caffeine intake selectively reverted memory but not mood deficits displayed by HM, which are associated with an increased density and functional impact of hippocampal A2AR controlling synaptic glutamatergic function.	Caffeine	13-21	adenosine A2a receptor	Mus musculus	180-184
28253085-4	2017	In a sample of 99 healthy volunteers (28 water pipe smokers, 30 secondhand tobacco smoke exposed persons, and 41 controls), we systematically compared CYP1A2 and CYP2A6 enzyme activities in vivo using caffeine urine test.	Caffeine	201-209	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	162-168
27890589-10	2017	Caffeine at moderate dose prevented the age-related increase of the SNAP-25, with no effect on adenosine A2A receptors.	Caffeine	0-8	synaptosomal-associated protein 25	Mus musculus	68-75
27890589-13	2017	On the other hand this substance sustained the adult anxious behavior over time in a less stressful paradigm, and this effect was coincident with changes in the SNAP-25, suggesting the involvement of this synaptic protein in the ability of caffeine to preserve changes related to emotionality with aging.	Caffeine	240-248	synaptosomal-associated protein 25	Mus musculus	161-168
28264466-1	2017	Caffeine is a promising drug for the management of neurodegenerative diseases such as Parkinson"s disease (PD), demonstrating neuroprotective properties that have been attributed to its interaction with the basal ganglia adenosine A2A receptor (A2AR).	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	221-243
28264466-1	2017	Caffeine is a promising drug for the management of neurodegenerative diseases such as Parkinson"s disease (PD), demonstrating neuroprotective properties that have been attributed to its interaction with the basal ganglia adenosine A2A receptor (A2AR).	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	245-249
28264466-7	2017	Interestingly, the new bivalent ligand presented higher potency as an A2AR inverse agonist than caffeine alone.	Caffeine	96-104	adenosine A2a receptor	Homo sapiens	70-74
28215251-0	2017	The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T&gt;C genotypes.	Caffeine	24-32	adenosine A2a receptor	Homo sapiens	91-98
27712037-4	2017	The pharmacokinetics of CYP selective substrates: caffeine, losartan, and omeprazole changed significantly in a diabetic NASH mouse model, indicating attenuation of the activity of Cyp1a2 and Cyp2c29, respectively.	Caffeine	50-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-27
27712037-4	2017	The pharmacokinetics of CYP selective substrates: caffeine, losartan, and omeprazole changed significantly in a diabetic NASH mouse model, indicating attenuation of the activity of Cyp1a2 and Cyp2c29, respectively.	Caffeine	50-58	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	181-187
27712037-4	2017	The pharmacokinetics of CYP selective substrates: caffeine, losartan, and omeprazole changed significantly in a diabetic NASH mouse model, indicating attenuation of the activity of Cyp1a2 and Cyp2c29, respectively.	Caffeine	50-58	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	192-199
28190324-5	2017	These cells constitutively express Rad51 and Rad54 throughout the entire cell cycle, and the formation of foci immediately increased in response to various types of DNA damage and replication stress, except for caffeine, which suppressed the Rad51-dependent HR pathway.	Caffeine	211-219	RAD51 recombinase	Homo sapiens	242-247
28228276-3	2017	(2017) describe that dietary caffeine inhibits the NLRC4 inflammasome, which is associated with disease-free aging.	Caffeine	29-37	NLR family CARD domain containing 4	Homo sapiens	51-56
28352352-3	2017	Noradrenaline-induced lipolysis was enhanced by caffeine, which markedly increased the protein expression of adipose triglyceride lipase and hormone sensitive lipase.	Caffeine	48-56	patatin-like phospholipase domain containing 2	Mus musculus	109-136
26642860-1	2017	OBJECTIVE: Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP).	Caffeine	11-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	131-135
26642860-2	2017	We have determined effects of caffeine and its xanthine metabolites on pancreatic acinar IP3R-mediated Ca2+ signalling and experimental AP.	Caffeine	30-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-93
26642860-12	2017	CONCLUSIONS: Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP.	Caffeine	13-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-84
27851893-7	2017	Main effects showed mean VO2 significantly higher (~1.5-2ml kg-1 min-1) for CAF for RPE4 and RPE7.	Caffeine	76-79	CD59 molecule (CD59 blood group)	Homo sapiens	65-70
28215251-6	2017	CONCLUSION: Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort.	Caffeine	144-152	adenosine A2a receptor	Homo sapiens	73-80
27697105-5	2017	RNAi depletion of hsp-16.2, a cytosolic chaperone, and cyp-35A family reduced the aversion phenotype, which was further reduced in cat-2 mutants, suggesting that dopaminergic signal is indeed dominantly required for the caffeine-induced food aversion.	Caffeine	220-228	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	18-26
28458351-9	2017	In contrast, caffeine significantly decreased the phosphorylation of Akt1.	Caffeine	13-21	thymoma viral proto-oncogene 1	Mus musculus	69-73
28458351-10	2017	These results suggest that caffeine inhibits HSC activation by antagonizing adenosine receptors, leading to Akt1 signaling activation.	Caffeine	27-35	thymoma viral proto-oncogene 1	Mus musculus	108-112
27818241-4	2017	KSR:ERL blends were investigated as coating materials to improve the robustness, mechanical strength and drug release from the HPMC matrix tablets containing propranolol HCl, caffeine and carbamazepine as model drugs.	Caffeine	175-183	kinase suppressor of ras 1	Homo sapiens	0-3
28674254-6	2017	Caffeine increased SWs even in dentate-CA3 mini-slices without the CA2 regions, in which adenosine A1 receptors are abundantly expressed in the hippocampus.	Caffeine	0-8	carbonic anhydrase 3	Mus musculus	39-42
28674254-7	2017	Thus, caffeine facilitates SWs by inhibiting adenosine A1 receptors in the hippocampal CA3 region or the dentate gyrus.	Caffeine	6-14	carbonic anhydrase 3	Mus musculus	87-90
27697105-5	2017	RNAi depletion of hsp-16.2, a cytosolic chaperone, and cyp-35A family reduced the aversion phenotype, which was further reduced in cat-2 mutants, suggesting that dopaminergic signal is indeed dominantly required for the caffeine-induced food aversion.	Caffeine	220-228	BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase	Caenorhabditis elegans	131-136
27823571-4	2017	On the level of Lewy bodies" formation, caffeine binds to alpha-synuclein protein inducing conformational changes and preventing their aggregation.	Caffeine	40-48	synuclein alpha	Homo sapiens	58-73
27924845-0	2016	Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: In vitro evidence.	Caffeine	0-8	annexin A1	Canis lupus familiaris	76-86
29225318-8	2017	Protein microarray analysis showed caffeine suppresses the secretion of inflammatory cytokines, interleukin-8 and plasminogen activator inhibitor-1 from Caco-2 cells.	Caffeine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	96-147
28062709-2	2017	We have previously demonstrated that caffeine blocks glioblastoma invasion and extends survival by inhibiting Ca2+ release channel inositol 1,4,5-trisphosphate receptor (IP3R) subtype 3.	Caffeine	37-45	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	170-174
27746260-9	2017	Both caffeine pretreatments in chronic stressed rats, and chronic caffeine in acute stressed ones reduced the elevated myeloperoxidase activities (p&lt;0.05-0.01).	Caffeine	5-13	myeloperoxidase	Rattus norvegicus	119-134
27746260-9	2017	Both caffeine pretreatments in chronic stressed rats, and chronic caffeine in acute stressed ones reduced the elevated myeloperoxidase activities (p&lt;0.05-0.01).	Caffeine	66-74	myeloperoxidase	Rattus norvegicus	119-134
27273149-0	2017	Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.	Caffeine	125-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-82
28811937-7	2017	For bitter taste, association between salivary leptin and caffeine threshold detection was observed only in preobese boys, with higher levels of salivary hormone in low sensitive individuals.	Caffeine	58-66	leptin	Homo sapiens	47-53
27799422-0	2017	MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-Mediated Rab7 Activation Regulates Tapetal Programmed Cell Death and Pollen Development.	Caffeine	37-45	SAND family protein	Arabidopsis thaliana	0-21
27799422-0	2017	MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-Mediated Rab7 Activation Regulates Tapetal Programmed Cell Death and Pollen Development.	Caffeine	37-45	RAB GTPase homolog G3B	Arabidopsis thaliana	80-84
27924845-6	2016	Western blotting and immunofluorescence study of COM crystal-binding proteins revealed significantly decreased level of annexin A1 on apical surface and its translocation into cytoplasm of the caffeine-treated cells, but no significant changes in other COM crystal-binding proteins (annexin A2, alpha-enolase, HSP70, and HSP90) were observed.	Caffeine	193-201	annexin A1	Canis lupus familiaris	120-130
27924845-6	2016	Western blotting and immunofluorescence study of COM crystal-binding proteins revealed significantly decreased level of annexin A1 on apical surface and its translocation into cytoplasm of the caffeine-treated cells, but no significant changes in other COM crystal-binding proteins (annexin A2, alpha-enolase, HSP70, and HSP90) were observed.	Caffeine	193-201	annexin A2	Canis lupus familiaris	283-293
27924845-6	2016	Western blotting and immunofluorescence study of COM crystal-binding proteins revealed significantly decreased level of annexin A1 on apical surface and its translocation into cytoplasm of the caffeine-treated cells, but no significant changes in other COM crystal-binding proteins (annexin A2, alpha-enolase, HSP70, and HSP90) were observed.	Caffeine	193-201	enolase 1	Canis lupus familiaris	295-308
27924845-6	2016	Western blotting and immunofluorescence study of COM crystal-binding proteins revealed significantly decreased level of annexin A1 on apical surface and its translocation into cytoplasm of the caffeine-treated cells, but no significant changes in other COM crystal-binding proteins (annexin A2, alpha-enolase, HSP70, and HSP90) were observed.	Caffeine	193-201	heat shock 70 kDa protein 1	Canis lupus familiaris	310-315
27924845-8	2016	Taken together, our findings showed an in vitro evidence of the protective mechanism of caffeine against kidney stone formation via translocation of annexin A1 from apical surface into cytoplasm to reduce the crystal-binding capacity of renal tubular epithelial cells.	Caffeine	88-96	annexin A1	Canis lupus familiaris	149-159
27509179-2	2016	Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozygotic (MZ) and dizygotic (DZ) twins.	Caffeine	42-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
27509179-0	2016	Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.	Caffeine	16-24	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	86-92
27797824-1	2016	Animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (ATR)-related apoptosis.	Caffeine	68-76	ATR serine/threonine kinase	Homo sapiens	166-169
27797824-5	2016	Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption (P = 1.78 x 10-8 for interaction) on BCC risk.	Caffeine	119-127	nei like DNA glycosylase 3	Homo sapiens	58-63
27509179-2	2016	Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozygotic (MZ) and dizygotic (DZ) twins.	Caffeine	42-50	N-acetyltransferase 2	Homo sapiens	89-120
27509179-2	2016	Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozygotic (MZ) and dizygotic (DZ) twins.	Caffeine	42-50	N-acetyltransferase 2	Homo sapiens	122-126
27509179-5	2016	However, when excluding smokers and users of hormonal contraceptives, 89% of caffeine AUC variation was due to genetic effects and, even in the entire group, 8% of caffeine AUC variation could be explained by a CYP1A1/1A2 promotor polymorphism (rs2470893).	Caffeine	164-172	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	211-217
27934696-14	2016	Examples include GIPR-caffeine interaction and obesity and include LAMP3-selenium interaction and Parkinson disease.	Caffeine	22-30	gastric inhibitory polypeptide receptor	Homo sapiens	17-21
27374593-4	2016	Caffeine quantification was linear from 2 to 75mgL(-1), with detection and quantification limits of 0.46mgL(-1) and 1.54mgL(-1), respectively.	Caffeine	0-8	LLGL scribble cell polarity complex component 1	Homo sapiens	47-53
27374593-4	2016	Caffeine quantification was linear from 2 to 75mgL(-1), with detection and quantification limits of 0.46mgL(-1) and 1.54mgL(-1), respectively.	Caffeine	0-8	LLGL scribble cell polarity complex component 1	Homo sapiens	104-110
27596362-6	2016	Administration of nicotine or caffeine caused a significant (P&lt;0.05) inhibition on AChE, ADA and Arg activities as well as a significant increase in NO level when compared with the control.	Caffeine	30-38	acetylcholinesterase	Mus musculus	86-90
27596362-6	2016	Administration of nicotine or caffeine caused a significant (P&lt;0.05) inhibition on AChE, ADA and Arg activities as well as a significant increase in NO level when compared with the control.	Caffeine	30-38	adenosine deaminase	Mus musculus	92-95
28480382-8	2017	The paired analysis comparing pre- and post-exercise, with and without caffeine showed that IL-6 presented higher post-exercise values in the GC group.	Caffeine	71-79	interleukin 6	Homo sapiens	92-96
27494660-9	2016	Caffeine concentrations in drinking water ranged from 1.8ngL-1 to values above 2.0mugL-1 while source-water concentrations varied from 40ngL-1 to about 19mugL-1.	Caffeine	0-8	leucine rich repeat containing 4C	Homo sapiens	57-62
27764027-4	2016	The aim of this study was to develop and validate a simplified but sensitive method for the simultaneous quantification of 5 probe drugs [caffeine (CYP1A2), metoprolol (CYP2D6), midazolam (CYP3A4), omeprazole (CYP2C19), and S-warfarin (CYP2C9)] in a previously validated cocktail using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.	Caffeine	138-146	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	148-154
28480382-11	2017	However, the caffeine effect on IL-6 level and muscle hypertrophy increase should be better investigated in future studies.	Caffeine	13-21	interleukin 6	Homo sapiens	32-36
27623393-1	2016	Sleep deprivation (SD) upsurges intracellular levels of adenosine, impairs adult neuronal cell proliferation (NCP) and cognition while caffeine, a non-selective adenosine A1 receptor (A1R) antagonist improves cognition and adult NCP during SD.	Caffeine	135-143	adenosine A1 receptor	Rattus norvegicus	161-182
27841305-7	2016	Interestingly, skeletal myotubes over-expressing MG53 or PRY-SPRY display a reduced intracellular Ca2+ release in response to K+-membrane depolarization or caffeine stimulation, suggesting a reduction in RyR1 channel activity.	Caffeine	156-164	tripartite motif-containing 72	Mus musculus	49-53
27663541-8	2016	Caffeine also selectively increased total expression of EAAT3 at PN7 and its expression in membrane fractions.	Caffeine	0-8	solute carrier family 1 member 1	Rattus norvegicus	56-61
27663541-9	2016	However, both EAAT1 and EAAT2 were reduced after caffeine treatment in P2 fraction.	Caffeine	49-57	solute carrier family 1 member 3	Rattus norvegicus	14-19
27663541-9	2016	However, both EAAT1 and EAAT2 were reduced after caffeine treatment in P2 fraction.	Caffeine	49-57	solute carrier family 1 member 2	Rattus norvegicus	24-29
27663541-12	2016	Our results suggest that in the developing rat retina caffeine modulates [3H]-d-Aspartate uptake by blocking adenosine A2AR.	Caffeine	54-62	adenosine A2a receptor	Rattus norvegicus	119-123
27717822-0	2016	Inhibiting c-Jun N-terminal kinase partially attenuates caffeine-dependent cell death without alleviating the caffeine-induced reduction in mitochondrial respiration in C2C12 skeletal myotubes.	Caffeine	56-64	mitogen-activated protein kinase 8	Homo sapiens	11-34
27717822-8	2016	Further, the addition of 400 muM dantrolene, a specific ryanodine receptor (RYR) inhibitor, prevented the caffeine-dependent increase in cell death and the reduction in basal and maximal OCR.	Caffeine	106-114	ryanodine receptor 1	Homo sapiens	56-74
27717822-8	2016	Further, the addition of 400 muM dantrolene, a specific ryanodine receptor (RYR) inhibitor, prevented the caffeine-dependent increase in cell death and the reduction in basal and maximal OCR.	Caffeine	106-114	ryanodine receptor 1	Homo sapiens	76-79
27717822-9	2016	We also discovered that caffeine treatment significantly increased the phosphorylation of JNK and that the addition of 30 muM SP600125 (JNKi), a specific JNK inhibitor, partially attenuated caffeine-induced cell death without preventing the caffeine-dependent reduction in basal and maximal OCR.	Caffeine	24-32	mitogen-activated protein kinase 8	Homo sapiens	90-93
27717822-9	2016	We also discovered that caffeine treatment significantly increased the phosphorylation of JNK and that the addition of 30 muM SP600125 (JNKi), a specific JNK inhibitor, partially attenuated caffeine-induced cell death without preventing the caffeine-dependent reduction in basal and maximal OCR.	Caffeine	190-198	mitogen-activated protein kinase 8	Homo sapiens	90-93
27717822-9	2016	We also discovered that caffeine treatment significantly increased the phosphorylation of JNK and that the addition of 30 muM SP600125 (JNKi), a specific JNK inhibitor, partially attenuated caffeine-induced cell death without preventing the caffeine-dependent reduction in basal and maximal OCR.	Caffeine	190-198	mitogen-activated protein kinase 8	Homo sapiens	136-139
27717822-9	2016	We also discovered that caffeine treatment significantly increased the phosphorylation of JNK and that the addition of 30 muM SP600125 (JNKi), a specific JNK inhibitor, partially attenuated caffeine-induced cell death without preventing the caffeine-dependent reduction in basal and maximal OCR.	Caffeine	190-198	mitogen-activated protein kinase 8	Homo sapiens	90-93
27717822-9	2016	We also discovered that caffeine treatment significantly increased the phosphorylation of JNK and that the addition of 30 muM SP600125 (JNKi), a specific JNK inhibitor, partially attenuated caffeine-induced cell death without preventing the caffeine-dependent reduction in basal and maximal OCR.	Caffeine	190-198	mitogen-activated protein kinase 8	Homo sapiens	136-139
27717822-11	2016	We conclude that caffeine increased cell death and reduced mitochondrial respiration in a calcium-dependent manner by activating the RYR and promoting reticular calcium release.	Caffeine	17-25	ryanodine receptor 1	Homo sapiens	133-136
27480796-4	2016	Phosphorylation of adducin (Ser713 in beta-adducin), which disrupts actin/spectrin interaction, is increased by quinpirole, haloperidol, or caffeine.	Caffeine	140-148	adducin 2 (beta)	Mus musculus	38-50
27853423-0	2016	Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors.	Caffeine	12-20	adenosine A2a receptor	Mus musculus	91-121
27169884-4	2016	The atp2.1pgs1Delta mutant was hypersensitive to Calcofluor White and caffeine, resistant to Zymolyase, but its sensitivity to caspofungin was the same as the strains with the standard PGS1 gene.	Caffeine	70-78	F1F0 ATP synthase subunit beta	Saccharomyces cerevisiae S288C	4-8
27312408-7	2016	The importance of A2ARs to control fear memory was further confirmed by the ability of SCH58261 (0.1 mg/kg; A2AR antagonist), caffeine (5 mg/kg), but not DPCPX (0.5 mg/kg; A1R antagonist), treatment for 7 days before fear conditioning onwards, to attenuate the retrieval of context fear after 24-48 h and after 7-8 days.	Caffeine	126-134	adenosine A2a receptor	Homo sapiens	18-22
27713762-0	2016	Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake.	Caffeine	81-89	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
27696877-2	2016	An ABC-transporter bfr1 from Schizosaccharomyces pombe was cloned and transformed into S. cerevisiae, resulting in enhancing caffeine resistance.	Caffeine	125-133	Bfr1p	Saccharomyces cerevisiae S288C	19-23
27696877-6	2016	Site-directed mutagenesis of these mutations confirmed at least one amino acid that conferred enhancing caffeine resistance in the mutated bfr1.	Caffeine	104-112	Bfr1p	Saccharomyces cerevisiae S288C	139-143
27713762-8	2016	Participants who reported habitually consuming more caffeine than the population average showed higher CYP1A2 activity than participants with lower than average caffeine consumption.	Caffeine	52-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	103-109
27713762-9	2016	Multiple regression analyses revealed that higher caffeine intake was potentially an important mediator of higher CYP1A2 activity.	Caffeine	50-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	114-120
27713762-10	2016	CONCLUSIONS: Estimated CYP1A2 enzyme activity, and thus speed of caffeine metabolism, was higher in our type-2 diabetes group; this was possibly due to higher intake of caffeine, a known inducer of CYP1A2 enzyme activity.	Caffeine	65-73	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	23-29
27713762-10	2016	CONCLUSIONS: Estimated CYP1A2 enzyme activity, and thus speed of caffeine metabolism, was higher in our type-2 diabetes group; this was possibly due to higher intake of caffeine, a known inducer of CYP1A2 enzyme activity.	Caffeine	65-73	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	198-204
27713762-10	2016	CONCLUSIONS: Estimated CYP1A2 enzyme activity, and thus speed of caffeine metabolism, was higher in our type-2 diabetes group; this was possibly due to higher intake of caffeine, a known inducer of CYP1A2 enzyme activity.	Caffeine	169-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	23-29
27713762-10	2016	CONCLUSIONS: Estimated CYP1A2 enzyme activity, and thus speed of caffeine metabolism, was higher in our type-2 diabetes group; this was possibly due to higher intake of caffeine, a known inducer of CYP1A2 enzyme activity.	Caffeine	169-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	198-204
26891133-0	2016	Caffeine intake enhances the benefits of sodium glucose transporter 2 inhibitor.	Caffeine	0-8	solute carrier family 5 member 2	Homo sapiens	41-69
27340146-10	2016	The largest change in SBP was seen with drinks administering &gt;=200 mg of caffeine (6.44 mm Hg, 95% CI = 4.62 to 8.27).	Caffeine	76-84	selenium binding protein 1	Homo sapiens	22-25
27704869-8	2016	Individual responses to CAF were labeled positive using a criterion of 13.4 m min-1 faster for CAF (vs. PLA).	Caffeine	24-27	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
27704869-8	2016	Individual responses to CAF were labeled positive using a criterion of 13.4 m min-1 faster for CAF (vs. PLA).	Caffeine	95-98	CD59 molecule (CD59 blood group)	Homo sapiens	78-83
27322594-4	2016	Consistent with these data, altered ryanodine receptor (RyR2) function and SERCA2a activity were found in MetS cardiomyocytes through Ca2+ spark measurements and caffeine application assay in a state in which sodium calcium exchanger was inhibited.	Caffeine	162-170	ryanodine receptor 2	Rattus norvegicus	56-60
26891133-11	2016	CONCLUSIONS: Caffeine intake enhanced the effect of SGLT-2 inhibitors.	Caffeine	13-21	solute carrier family 5 member 2	Homo sapiens	52-58
27657916-3	2016	In this work we have demonstrated that physiological concentrations of caffeine reduce the proliferation rate of H460 cells: along with the modulation of p53, pAKT and Cyclin D1, caffeine also determines a significant FHC up-regulation through the activation of its transcriptional efficiency.	Caffeine	71-79	cyclin D1	Homo sapiens	168-177
27473274-0	2016	Caffeine intake inverts the effect of adenosine on myocardial perfusion during stress as measured by T1 mapping.	Caffeine	0-8	CD5 molecule	Homo sapiens	101-103
27473274-2	2016	We hypothesized that the antagonistic effect of caffeine can be measured by T1 relaxation times in rest and adenosine stress cardiac magnetic resonance imaging (CMR), as T1 mapping techniques are sensitive to changes in myocardial blood volume.	Caffeine	48-56	CD5 molecule	Homo sapiens	76-78
27473274-9	2016	The &lt;4H caffeine group showed inverted  T1 of -7.8 % (T1rest 975 +- 42 ms, T1stress 898 +- 51 ms, p &lt; 0.0005).	Caffeine	11-19	CD5 molecule	Homo sapiens	43-45
27473274-10	2016	The &gt;8H caffeine group showed reduced T1 reactivity (1.8 %; T1rest 979 ms, T1stress 997 ms) compared to the controls (4.3 %; T1rest 977 +- 40 ms, T1stress 1018 +- 40 ms), p &lt; 0.0005.	Caffeine	11-19	CD5 molecule	Homo sapiens	41-43
27473274-12	2016	Caffeine intake inverts the adenosine effect during stress perfusion CMR as measured by T1 mapping.	Caffeine	0-8	CD5 molecule	Homo sapiens	88-90
27482605-1	2016	S-Adenosyl-l-methionine (SAM) dependent xanthosine methyltransferase (XMT) is the key enzyme that catalyzes the first methyl transfer in the caffeine biosynthesis pathway to produce the intermediate 7-methylxanthosine (7mXR).	Caffeine	141-149	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	220-223
26971583-7	2016	When XP-V cell strains, including one derived from a Japanese patient, were infected with Ad-XPV, exposed to UV-B and cultured with 1 mmol/L of caffeine, flow cytometry detected a characteristic decrease in the S phase in all the XP-V cell strains.	Caffeine	144-152	DNA polymerase eta	Homo sapiens	5-9
26971583-7	2016	When XP-V cell strains, including one derived from a Japanese patient, were infected with Ad-XPV, exposed to UV-B and cultured with 1 mmol/L of caffeine, flow cytometry detected a characteristic decrease in the S phase in all the XP-V cell strains.	Caffeine	144-152	DNA polymerase eta	Homo sapiens	230-234
27555807-8	2016	Using ectopic expressions, we show that the caffeine receptor in neuron D1 requires the function of at least four receptor genes: the putative co-receptors Gr33a, Gr66a, the putative caffeine-specific receptor Gr93a, and yet unknown additional molecular component(s).	Caffeine	44-52	Gustatory receptor 33a	Drosophila melanogaster	156-161
27619503-3	2016	Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain.	Caffeine	128-136	Hugin	Drosophila melanogaster	18-23
27413009-7	2016	However, strikingly, when Y268C/A mutations were combined with the kinase-dead mutation, K54R, or mutations at the TEY motif, T190A+Y192F, the resulting proteins still allowed mkk1 mkk2  cells to proliferate under caffeine stress.	Caffeine	214-222	mitogen-activated protein kinase kinase MKK1	Saccharomyces cerevisiae S288C	176-180
27510168-0	2016	The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.	Caffeine	4-12	adenosine A2a receptor	Homo sapiens	21-43
27510168-0	2016	The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.	Caffeine	4-12	nuclear receptor subfamily 3 group C member 1	Homo sapiens	95-118
27510168-1	2016	Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer"s disease (AD) patients.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	98-120
27510168-1	2016	Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer"s disease (AD) patients.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	122-126
27510168-7	2016	This supports the idea that the procognitive effects of A2AR antagonists, namely caffeine, on Alzheimer"s and age-related cognitive impairments may rely on its ability to modulate GR actions.	Caffeine	81-89	adenosine A2a receptor	Homo sapiens	56-60
27261728-4	2016	Therefore, this work aims to model CNF-coated paper substrates as controlled release system for food-packaging using release data obtained for two model molecules, namely caffeine and chlorhexidine digluconate.	Caffeine	171-179	NPHS1 adhesion molecule, nephrin	Homo sapiens	35-38
27487451-2	2016	Recently, several studies on AD transgenic mice have shown the effect of caffeine in significantly reducing the Abeta amyloid level in their brains.	Caffeine	73-81	amyloid beta (A4) precursor protein	Mus musculus	112-117
27168116-5	2016	Therefore, in this study, we have examined the effect of injections of CART peptide (2.5mug) into the NAc core on the locomotor effects of caffeine in male Sprague-Dawley rats.	Caffeine	139-147	CART prepropeptide	Rattus norvegicus	71-75
27532605-8	2016	Caffeine reduced ratings of perceived exertion (mean difference: 0.5 +- 0.7; 95% likely range: 0.1 to 0.9) and heart rate (mean difference: 3.6 +- 4.2 b min-1; 95% likely range: 1.3 to 5.8 b min-1) during exercise, with the effect on the latter dissipating as exercise intensity increased.	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	153-158
27532605-8	2016	Caffeine reduced ratings of perceived exertion (mean difference: 0.5 +- 0.7; 95% likely range: 0.1 to 0.9) and heart rate (mean difference: 3.6 +- 4.2 b min-1; 95% likely range: 1.3 to 5.8 b min-1) during exercise, with the effect on the latter dissipating as exercise intensity increased.	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	191-196
27555807-8	2016	Using ectopic expressions, we show that the caffeine receptor in neuron D1 requires the function of at least four receptor genes: the putative co-receptors Gr33a, Gr66a, the putative caffeine-specific receptor Gr93a, and yet unknown additional molecular component(s).	Caffeine	44-52	Gustatory receptor 66a	Drosophila melanogaster	163-168
27555807-8	2016	Using ectopic expressions, we show that the caffeine receptor in neuron D1 requires the function of at least four receptor genes: the putative co-receptors Gr33a, Gr66a, the putative caffeine-specific receptor Gr93a, and yet unknown additional molecular component(s).	Caffeine	44-52	Gustatory receptor 93a	Drosophila melanogaster	210-215
27135883-10	2016	NCX forward mode activity (caffeine response) was progressively reduced, while NCX protein expression was up-regulated, suggesting increased NCX reverse mode activity in NXT.	Caffeine	27-35	solute carrier family 8 member A1	Rattus norvegicus	0-3
27670114-3	2016	Here, we report that miR-301b augments pro-inflammatory response during pulmonary infection, and caffeine suppresses the effect of miR-301b and thereby augments respiratory immunity.	Caffeine	97-105	microRNA 301b	Mus musculus	131-139
27670114-5	2016	Importantly, caffeine decreases miR-301b expression through negative regulation of the cAMP/PKA/NF-kappaB axis.	Caffeine	13-21	microRNA 301b	Mus musculus	32-40
27527212-6	2016	Participants who reported poor sleep (PSQI global score &gt;= 5) consumed 192.1 +- 122.5 mg (M +- SD) of caffeine which was significantly more than those who reported good sleep quality (PSQI global score &lt; 5; 125.2 +- 62.6 mg; p = 0.008).	Caffeine	105-113	MSD	Homo sapiens	93-100
27318879-3	2016	Inter-individual variability in hepatic intrinsic clearance of CYP1A2 substrates (CLint,h,1A2) was estimated using dispersion model based on the inter-individual variability (N = 96) of the AUC of caffeine, a major CYP1A2 substrate.	Caffeine	197-205	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69
27235390-6	2016	Maximal K201 doses at 80 microM produced ~37% of the increase in SkM SR Ca(2+) release observed with the RyR agonist caffeine.	Caffeine	117-125	ryanodine receptor 1	Homo sapiens	105-108
27193025-6	2016	In healthy volunteers, the post-AAC increase in capillary ammonia levels was contained by both the administration of LOLA and of caffeine (significant differences between 10:00 and 14:00 h).	Caffeine	129-137	glycine-N-acyltransferase	Homo sapiens	32-35
27193025-9	2016	In conclusion, both LOLA and caffeine contained the AAC-induced increase in capillary ammonia, especially in healthy volunteers.	Caffeine	29-37	glycine-N-acyltransferase	Homo sapiens	52-55
27193025-10	2016	Caffeine also counteracted the AAC effects on sleepiness/EEG amplitude.	Caffeine	0-8	glycine-N-acyltransferase	Homo sapiens	31-34
26842874-5	2016	Notably, several food compounds, such as teasaponins, resveratrol, celastrol, caffeine, and taurine among others, are able to restore the leptin signaling in neurons by overexpressing anorexigenic peptides (proopiomelanocortin) and/or repressing orexigenic peptides (neuropeptide Y/agouti-related peptide), thus decreasing food intake.	Caffeine	78-86	leptin	Homo sapiens	138-144
27563362-8	2016	Emerging evidence from both in vivo and in vitro studies suggests that caffeine may reduce parkinsonian motor symptoms by antagonising the adenosine A2A receptor, which is predominately expressed in the basal ganglia.	Caffeine	71-79	adenosine A2a receptor	Homo sapiens	139-161
27221759-6	2016	Immunohistochemical analysis showed a decrease in retinal content of tyrosine hydroxylase, calbindin and choline acetyltransferase, but not Brn3a, after 48 h of caffeine injection.	Caffeine	161-169	calbindin 1	Gallus gallus	91-100
27221759-6	2016	Immunohistochemical analysis showed a decrease in retinal content of tyrosine hydroxylase, calbindin and choline acetyltransferase, but not Brn3a, after 48 h of caffeine injection.	Caffeine	161-169	choline O-acetyltransferase	Gallus gallus	105-130
27221759-7	2016	Furthermore, retinas exposed to caffeine had increased levels of phosphorylated extracellular signal-regulated kinase and cAMP-response element binding protein.	Caffeine	32-40	cAMP responsive element binding protein 1	Gallus gallus	122-159
27221759-8	2016	Overall, we show an in vivo regulation of the adenosine system, extracellular signal-regulated kinase and cAMP-response element binding protein function and protein expression of specific neurotransmitter systems by caffeine in the developing retina.	Caffeine	216-224	cAMP responsive element binding protein 1	Gallus gallus	106-143
27486388-8	2016	Additionally, we show that a specific pair of pharyngeal GRNs, DP1, responds to caffeine by calcium imaging.	Caffeine	80-88	Dodeca-satellite-binding protein 1	Drosophila melanogaster	63-66
27413044-8	2016	Exogenous PEDF treatment (10 nmol/L) caused a significant decrease in amplitudes of isoproterenol-stimulated myocyte shortening, Ca(2+) transients, and caffeine-evoked Ca(2+) transients in vitro.	Caffeine	152-160	serpin family F member 1	Rattus norvegicus	10-14
27434302-5	2016	METHODS: To investigate this we used a drug cocktail validated in humans consisting of five widely prescribed drugs as probes for specific P450 enzymes: caffeine (CYP1A2), metoprolol (CYP2D6), omeprazole (CYP2C19), midazolam (CYP3A4) and s-warfarin (CYP2C9).	Caffeine	153-161	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	139-143
27434302-14	2016	The changes in drug clearance correlated with the expression pattern of the specific P450 enzymes in case of Cyp1a2-caffeine and Cyp2c37-omeprazole.	Caffeine	116-124	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	85-89
27434302-14	2016	The changes in drug clearance correlated with the expression pattern of the specific P450 enzymes in case of Cyp1a2-caffeine and Cyp2c37-omeprazole.	Caffeine	116-124	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	109-115
27248826-9	2016	Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1.	Caffeine	55-63	signal transducer and activator of transcription 3	Homo sapiens	234-239
27404570-0	2016	Decreased Caffeine-Induced Locomotor Activity via Microinjection of CART Peptide into the Nucleus Accumbens Is Linked to Inhibition of the pCaMKIIa-D3R Interaction.	Caffeine	10-18	CART prepropeptide	Rattus norvegicus	68-72
27404570-0	2016	Decreased Caffeine-Induced Locomotor Activity via Microinjection of CART Peptide into the Nucleus Accumbens Is Linked to Inhibition of the pCaMKIIa-D3R Interaction.	Caffeine	10-18	dopamine receptor D3	Rattus norvegicus	148-151
27404570-2	2016	After repeated oral administration of caffeine (30 mg/kg) for five days, microinjection of CART peptide (0.08 muM/0.5 mul/hemisphere) into the NAc affected locomotor behavior.	Caffeine	38-46	CART prepropeptide	Rattus norvegicus	91-95
27404570-4	2016	We found that CART attenuated the caffeine-mediated enhancement of depolarization-induced Ca2+ influx and CaMKIIalpha phosphorylation in cultured NAc neurons.	Caffeine	34-42	CART prepropeptide	Rattus norvegicus	14-18
27404570-5	2016	Repeated microinjection of CART peptides into the NAc decreased the caffeine-induced enhancement of Ca2+ channels activity, pCaMKIIalpha levels, the pCaMKIIalpha-D3R interaction, D3R phosphorylation, cAMP levels, PKA activity and pCREB levels in the NAc.	Caffeine	68-76	CART prepropeptide	Rattus norvegicus	27-31
27404570-5	2016	Repeated microinjection of CART peptides into the NAc decreased the caffeine-induced enhancement of Ca2+ channels activity, pCaMKIIalpha levels, the pCaMKIIalpha-D3R interaction, D3R phosphorylation, cAMP levels, PKA activity and pCREB levels in the NAc.	Caffeine	68-76	dopamine receptor D3	Rattus norvegicus	162-165
27404570-5	2016	Repeated microinjection of CART peptides into the NAc decreased the caffeine-induced enhancement of Ca2+ channels activity, pCaMKIIalpha levels, the pCaMKIIalpha-D3R interaction, D3R phosphorylation, cAMP levels, PKA activity and pCREB levels in the NAc.	Caffeine	68-76	dopamine receptor D3	Rattus norvegicus	179-182
27404570-7	2016	These results suggest that caffeine-induced CREB phosphorylation in the NAc was ameliorated by CART peptide due to its inhibition of D3R phosphorylation.	Caffeine	27-35	cAMP responsive element binding protein 1	Rattus norvegicus	44-48
27404570-7	2016	These results suggest that caffeine-induced CREB phosphorylation in the NAc was ameliorated by CART peptide due to its inhibition of D3R phosphorylation.	Caffeine	27-35	CART prepropeptide	Rattus norvegicus	95-99
27404570-7	2016	These results suggest that caffeine-induced CREB phosphorylation in the NAc was ameliorated by CART peptide due to its inhibition of D3R phosphorylation.	Caffeine	27-35	dopamine receptor D3	Rattus norvegicus	133-136
27248826-9	2016	Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1.	Caffeine	55-63	AKT serine/threonine kinase 1	Homo sapiens	241-244
27248826-9	2016	Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1.	Caffeine	55-63	lin-28 homolog B	Homo sapiens	246-252
27248826-9	2016	Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1.	Caffeine	55-63	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	257-261
27223070-3	2016	METHODS: NAT2 acetylation status was determined by both single nucleotide polymorphisms (SNPs) and caffeine metabolic ratio (CMR), in a population-based study of 494 bladder cancer patients and 507 control subjects in Shanghai, China.	Caffeine	99-107	N-acetyltransferase 2	Homo sapiens	9-13
27207666-5	2016	CYP1A2 activity was assessed in urine with the caffeine challenge test and head hair melanin was estimated by UV spectrophotometry.	Caffeine	47-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
28757735-5	2016	MATERIALS AND METHODS: Cell viability and activity of HDAC1 and p300 in RT2 glioma cells were assayed after treatment with caffeine for 48 hours.	Caffeine	123-131	histone deacetylase 1	Homo sapiens	54-59
28757735-5	2016	MATERIALS AND METHODS: Cell viability and activity of HDAC1 and p300 in RT2 glioma cells were assayed after treatment with caffeine for 48 hours.	Caffeine	123-131	E1A binding protein p300	Homo sapiens	64-68
28757735-7	2016	HDAC1 protein activity decreased significantly with various concentrations of caffeine, whereas the activity of p300 increased significantly.	Caffeine	78-86	histone deacetylase 1	Homo sapiens	0-5
28757735-8	2016	In addition, the viability of RT2 cells remained high, but HDAC1 activity decreased, and p300 activity increased markedly with 0.5mM caffeine treatment.	Caffeine	133-141	E1A binding protein p300	Homo sapiens	89-93
28757735-10	2016	siRNA downregulated p300 and thus increased the viability of RT2 cells, therefore, caffeine combined with siRNA abolished the efficacy of caffeine, which confirmed that caffeine upregulated p300 and reduced cell viability.	Caffeine	83-91	E1A binding protein p300	Homo sapiens	190-194
28757735-10	2016	siRNA downregulated p300 and thus increased the viability of RT2 cells, therefore, caffeine combined with siRNA abolished the efficacy of caffeine, which confirmed that caffeine upregulated p300 and reduced cell viability.	Caffeine	138-146	E1A binding protein p300	Homo sapiens	190-194
28757735-10	2016	siRNA downregulated p300 and thus increased the viability of RT2 cells, therefore, caffeine combined with siRNA abolished the efficacy of caffeine, which confirmed that caffeine upregulated p300 and reduced cell viability.	Caffeine	138-146	E1A binding protein p300	Homo sapiens	190-194
28757735-11	2016	We also found increased HDAC1 activity when RT2 cells were treated with a combination of caffeine and miR-449a and thus increased the viability of RT2 cells.	Caffeine	89-97	histone deacetylase 1	Homo sapiens	24-29
28757735-12	2016	CONCLUSION: Our data suggest that a new strategy, caffeine, could increase glioma cell death by decreasing HDAC1 activity and/or by increasing p300 activity.	Caffeine	50-58	histone deacetylase 1	Homo sapiens	107-112
28757735-12	2016	CONCLUSION: Our data suggest that a new strategy, caffeine, could increase glioma cell death by decreasing HDAC1 activity and/or by increasing p300 activity.	Caffeine	50-58	E1A binding protein p300	Homo sapiens	143-147
27260469-0	2016	Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway.	Caffeine	0-8	cathepsin B	Homo sapiens	62-73
27260469-0	2016	Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	78-82
27260469-4	2016	Caffeine decreased mRNA, protein expression, and activity of cathepsin B.	Caffeine	0-8	cathepsin B	Homo sapiens	61-72
27260469-5	2016	Besides, mRNA and protein expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) was upregulated by caffeine treatment, whereas matrix metalloproteinase-2 (MMP-2) was downregulated.	Caffeine	108-116	TIMP metallopeptidase inhibitor 1	Homo sapiens	40-79
27260469-5	2016	Besides, mRNA and protein expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) was upregulated by caffeine treatment, whereas matrix metalloproteinase-2 (MMP-2) was downregulated.	Caffeine	108-116	TIMP metallopeptidase inhibitor 1	Homo sapiens	81-87
27260469-6	2016	The expression of Ki67, p-p38, phospforylated extracellular regulated protein kinases (p-ERK), and membranous integrin beta1 and beta3 was decreased by caffeine.	Caffeine	152-160	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	31-85
27260469-6	2016	The expression of Ki67, p-p38, phospforylated extracellular regulated protein kinases (p-ERK), and membranous integrin beta1 and beta3 was decreased by caffeine.	Caffeine	152-160	mitogen-activated protein kinase 1	Homo sapiens	89-92
27260469-6	2016	The expression of Ki67, p-p38, phospforylated extracellular regulated protein kinases (p-ERK), and membranous integrin beta1 and beta3 was decreased by caffeine.	Caffeine	152-160	integrin subunit beta 1	Homo sapiens	110-124
27260469-6	2016	The expression of Ki67, p-p38, phospforylated extracellular regulated protein kinases (p-ERK), and membranous integrin beta1 and beta3 was decreased by caffeine.	Caffeine	152-160	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	129-134
27260469-7	2016	The Rho-associated protein kinase (ROCK) inhibitor, Y27632, blocked the caffeine-mediated reduction of cathepsin B, phosphorylated focal adhesion kinase (p-FAK), and p-ERK, and invasion.	Caffeine	72-80	cathepsin B	Homo sapiens	103-114
27260469-7	2016	The Rho-associated protein kinase (ROCK) inhibitor, Y27632, blocked the caffeine-mediated reduction of cathepsin B, phosphorylated focal adhesion kinase (p-FAK), and p-ERK, and invasion.	Caffeine	72-80	protein tyrosine kinase 2	Homo sapiens	156-159
27260469-7	2016	The Rho-associated protein kinase (ROCK) inhibitor, Y27632, blocked the caffeine-mediated reduction of cathepsin B, phosphorylated focal adhesion kinase (p-FAK), and p-ERK, and invasion.	Caffeine	72-80	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	166-171
27260469-8	2016	Moreover, caffeine decreased the tumor size, cathepsin B and Ki67 expression in animal model.	Caffeine	10-18	cathepsin B	Homo sapiens	45-56
27260469-9	2016	Caffeine reduced the invasion of glioma cells through ROCK-cathepsin B/FAK/ERK signaling pathway and tumor growth in orthotopic xenograft animal model, supporting the anti-cancer potential in glioma therapy.	Caffeine	0-8	cathepsin B	Homo sapiens	59-70
27260469-9	2016	Caffeine reduced the invasion of glioma cells through ROCK-cathepsin B/FAK/ERK signaling pathway and tumor growth in orthotopic xenograft animal model, supporting the anti-cancer potential in glioma therapy.	Caffeine	0-8	protein tyrosine kinase 2	Homo sapiens	71-74
27260469-9	2016	Caffeine reduced the invasion of glioma cells through ROCK-cathepsin B/FAK/ERK signaling pathway and tumor growth in orthotopic xenograft animal model, supporting the anti-cancer potential in glioma therapy.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	75-78
26982450-1	2016	BACKGROUND: Serum caffeine concentrations &gt;20 mug/ml (100 mumol/l) in infants treated for apnea of prematurity increases TNF-alpha and decreases IL-10, changes that perhaps are linked to comorbidities.	Caffeine	18-26	tumor necrosis factor	Homo sapiens	124-133
26982450-1	2016	BACKGROUND: Serum caffeine concentrations &gt;20 mug/ml (100 mumol/l) in infants treated for apnea of prematurity increases TNF-alpha and decreases IL-10, changes that perhaps are linked to comorbidities.	Caffeine	18-26	interleukin 10	Homo sapiens	148-153
26982450-5	2016	RESULTS: Caffeine at &lt;=100 mumol/l decreased TNF-alpha levels (~25%, P = 0.01) and cAMP.	Caffeine	9-17	tumor necrosis factor	Homo sapiens	48-57
26982450-6	2016	All caffeine concentrations decreased IL-10 levels (17-35%, P &lt; 0.01).	Caffeine	4-12	interleukin 10	Homo sapiens	38-43
26982450-8	2016	Caffeine further decreased TNF-alpha following A3R and PDE blockades.	Caffeine	0-8	tumor necrosis factor	Homo sapiens	27-36
26982450-8	2016	Caffeine further decreased TNF-alpha following A3R and PDE blockades.	Caffeine	0-8	aldehyde dehydrogenase 7 family member A1	Homo sapiens	55-58
26982450-9	2016	Caffeine concentrations directly correlated to TLR4 gene expression (r = 0.84; P &lt; 0.001).	Caffeine	0-8	toll like receptor 4	Homo sapiens	47-51
26982450-11	2016	Besides A1R blockade, caffeine"s upregulation of TLR4 may promote inflammation at high concentrations.	Caffeine	22-30	toll like receptor 4	Homo sapiens	49-53
27016674-4	2016	The most abundant compound was caffeine followed by diclofenac, DEET, mefenamic acid, fluoxetine, ibuprofen and carbamazepine with mean concentrations from 2.0 to 80.8ngL(-1).	Caffeine	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	167-170
27013634-8	2016	However, depletion of RyR-gated store with caffeine failed to activate Ca(2+) entry.	Caffeine	43-51	ryanodine receptor 2	Rattus norvegicus	22-25
27013634-9	2016	Inclusion of ryanodine, which itself did not cause Ca(2+) entry, uncovered caffeine-induced SOCE in a concentration-dependent manner, suggesting binding of ryanodine to RyR is permissive for the process.	Caffeine	75-83	ryanodine receptor 2	Rattus norvegicus	169-172
28757735-0	2016	Effects of caffeine on cell viability and activity of histone deacetylase 1 and histone acetyltransferase in glioma cells.	Caffeine	11-19	histone deacetylase 1	Homo sapiens	54-75
28757735-4	2016	This study aimed to assess the activities of histone deacetylase 1 (HDAC1) and histone acetyltransferase (p300) in RT2 glioma cells treated with caffeine.	Caffeine	145-153	histone deacetylase 1	Homo sapiens	45-66
28757735-4	2016	This study aimed to assess the activities of histone deacetylase 1 (HDAC1) and histone acetyltransferase (p300) in RT2 glioma cells treated with caffeine.	Caffeine	145-153	histone deacetylase 1	Homo sapiens	68-73
28757735-4	2016	This study aimed to assess the activities of histone deacetylase 1 (HDAC1) and histone acetyltransferase (p300) in RT2 glioma cells treated with caffeine.	Caffeine	145-153	E1A binding protein p300	Homo sapiens	106-110
26304238-7	2016	The results indicated that caffeine altered the expression pattern of Cx40, Cx43 and Cx45 at non-cytotoxic concentrations (&gt;=2000 mum), i.e., at concentrations that did not affect total cell protein and cell viability.	Caffeine	27-35	gap junction protein alpha 1	Gallus gallus	76-80
26304238-7	2016	The results indicated that caffeine altered the expression pattern of Cx40, Cx43 and Cx45 at non-cytotoxic concentrations (&gt;=2000 mum), i.e., at concentrations that did not affect total cell protein and cell viability.	Caffeine	27-35	gap junction protein gamma 3	Gallus gallus	85-89
26304238-8	2016	In addition the effects of caffeine on cardiomyocyte formation and function (contractile activity score) were correlated with modulation of Cxs (Cx40, Cx43 and Cx45) expression, at above and including 2000 mum caffeine concentrations (P &lt; 0.05).	Caffeine	27-35	gap junction protein alpha 1	Gallus gallus	151-155
26304238-8	2016	In addition the effects of caffeine on cardiomyocyte formation and function (contractile activity score) were correlated with modulation of Cxs (Cx40, Cx43 and Cx45) expression, at above and including 2000 mum caffeine concentrations (P &lt; 0.05).	Caffeine	27-35	gap junction protein gamma 3	Gallus gallus	160-164
26503341-2	2016	3-N-Demethylation of caffeine (1,3,7-trimethylxanthine) is mediated by human cytochrome P450 1A2, whereas 7-N-demethylation and C-8-hydroxylation are reportedly catalyzed by monkey P450 2C9 and rat P450 1A2, respectively.	Caffeine	21-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-96
26503341-2	2016	3-N-Demethylation of caffeine (1,3,7-trimethylxanthine) is mediated by human cytochrome P450 1A2, whereas 7-N-demethylation and C-8-hydroxylation are reportedly catalyzed by monkey P450 2C9 and rat P450 1A2, respectively.	Caffeine	21-29	homeobox C8	Homo sapiens	128-131
26503341-2	2016	3-N-Demethylation of caffeine (1,3,7-trimethylxanthine) is mediated by human cytochrome P450 1A2, whereas 7-N-demethylation and C-8-hydroxylation are reportedly catalyzed by monkey P450 2C9 and rat P450 1A2, respectively.	Caffeine	31-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-96
26684634-0	2016	Caffeine affects CD8+ lymphocyte apoptosis and migration differently in naive and familiar individuals following moderate intensity exercise.	Caffeine	0-8	CD8a molecule	Homo sapiens	17-20
27336719-5	2016	Si-Jph3 lowered the insulin secretory response to Ca(2+) signaling in the presence of glucose, and reduced [Ca(2+)]c transient amplitude triggered by caffeine.	Caffeine	150-158	junctophilin 3	Mus musculus	3-7
27169737-6	2016	As a result of increased activity of mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine-induced Ca(2+) transients, was lower in CPVT VMs and PCs than respective controls, and sarcoplasmic reticulum fractional release was greater in both CPVT PCs and VMs than respective controls.	Caffeine	128-136	ryanodine receptor 2, cardiac	Mus musculus	44-69
27265833-6	2016	Knocking down endogenous Best3 expression in myoblasts makes these cells more excitable in response to Ca(2+) mobilizing reagents, such as caffeine.	Caffeine	139-147	bestrophin 3	Mus musculus	25-30
27275394-4	2016	We briefly analyze the first retrospective study to examine caffeine consumption and PD risk in a LRRK2 R1628P cohort.	Caffeine	60-68	leucine rich repeat kinase 2	Homo sapiens	98-103
27271602-0	2016	v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage.	Caffeine	37-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
26849106-4	2016	We show that the RYR2 response to caffeine at the single-channel level is significantly modified by the nature of luminal M(2+).	Caffeine	34-42	ryanodine receptor 2	Homo sapiens	17-21
26684634-7	2016	However, CD8+ lymphocyte cell death and migration responses were observed to be significantly greater at each sampling point in caffeine-familiar individuals (P &lt;0.05).	Caffeine	128-136	CD8a molecule	Homo sapiens	9-12
26684634-8	2016	It is possible that chronic caffeine supplementation may prime CD8+ cell receptors for responsiveness to apoptosis and migration and the consequence of this form of immunosuppression in the post-exercise period should be determined.	Caffeine	28-36	CD8a molecule	Homo sapiens	63-66
26905951-2	2016	Although both caffeine and more specific antagonists of the A2A subtype of adenosine receptor (A2AR) have been found to confer protection in animal models of PD, the dependence of caffeine"s neuroprotective effects on the A2AR is not known.	Caffeine	180-188	adenosine A2a receptor	Mus musculus	222-226
27184118-5	2016	In response to high [K(+)], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated in Stac3-deleted muscle were 29% (P &lt; 0.05), 58% (P = 0.08), and 55% (P &lt; 0.05) of those in control muscle, respectively.	Caffeine	28-36	SH3 and cysteine rich domain 3	Mus musculus	103-108
27184118-7	2016	However, in response to 4-CMC or caffeine, similar increases in intracellular calcium concentration were observed in Stac3-deleted and control myotubes.	Caffeine	33-41	SH3 and cysteine rich domain 3	Mus musculus	117-122
26062916-6	2016	Subjects were genotyped and classified as AA homozygotes or AC heterozygotes for the rs762551 polymorphism of the CYP1A2 gene involved in caffeine metabolism.	Caffeine	138-146	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	114-120
26911575-0	2016	Caffeine inhibits TGFbeta activation in epithelial cells, interrupts fibroblast responses to TGFbeta, and reduces established fibrosis in ex vivo precision-cut lung slices.	Caffeine	0-8	transforming growth factor beta 1	Homo sapiens	18-25
26911575-0	2016	Caffeine inhibits TGFbeta activation in epithelial cells, interrupts fibroblast responses to TGFbeta, and reduces established fibrosis in ex vivo precision-cut lung slices.	Caffeine	0-8	transforming growth factor beta 1	Homo sapiens	93-100
26911575-4	2016	Recently, caffeine has been shown to exhibit antifibrotic effects in the liver in part through reducing collagen expression and deposition, and reducing expression of the profibrotic cytokine TGFbeta.	Caffeine	10-18	transforming growth factor beta 1	Homo sapiens	192-199
26911575-7	2016	Caffeine inhibited TGFbeta activation by lung epithelial cells in a concentration-dependent manner but had no effect on TGFbeta activation in fibroblasts.	Caffeine	0-8	transforming growth factor beta 1	Homo sapiens	19-26
26911575-8	2016	Importantly, however, caffeine abrogated profibrotic responses to TGFbeta in lung fibroblasts.	Caffeine	22-30	transforming growth factor beta 1	Homo sapiens	66-73
26905951-4	2016	In WT and in heterozygous A2AR KO mice caffeine pretreatment (25mg/kgip) significantly attenuated MPTP-induced depletion of striatal dopamine.	Caffeine	39-47	adenosine A2a receptor	Mus musculus	26-30
26905951-6	2016	In forebrain neuron A2AR cKO mice, caffeine lost its locomotor stimulant effect, whereas its neuroprotective effect was mostly preserved.	Caffeine	35-43	adenosine A2a receptor	Mus musculus	20-24
26905951-8	2016	Taken together, these results indicate that neuroprotection by caffeine in the MPTP model of PD relies on the A2AR, although the specific cellular localization of these receptors remains to be determined.	Caffeine	63-71	adenosine A2a receptor	Mus musculus	110-114
27199668-6	2016	While treatment with the RyR agonist caffeine significantly promoted the autophagic death of insulin-deficient HCN cells, treatment with its inhibitor dantrolene prevented the induction of autophagy following insulin withdrawal.	Caffeine	37-45	ryanodine receptor 1	Homo sapiens	25-28
27242547-6	2016	Both EDL and SOL muscles from Dmp1 null mice also produced less force after the addition of caffeine (which releases calcium from the sarcoplasmic reticulum) which may indicate problems in excitation contraction coupling in these mice.	Caffeine	92-100	dentin matrix protein 1	Mus musculus	30-34
27173481-9	2016	The renal alpha-ENaC expression and ENaC activity of rats decreased after chronic caffeine administration.	Caffeine	82-90	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	10-20
27173481-9	2016	The renal alpha-ENaC expression and ENaC activity of rats decreased after chronic caffeine administration.	Caffeine	82-90	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	16-20
27173481-10	2016	Caffeine increased phosphorylation of AMPK and decrease alpha-ENaC expression in cortical collecting duct cells.	Caffeine	0-8	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	56-66
27173481-11	2016	Inhibiting AMPK abolished the effect of caffeine on alpha-ENaC.	Caffeine	40-48	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	52-62
27173481-12	2016	Chronic caffeine intake prevented the development of salt-sensitive hypertension through promoting urinary sodium excretion, which was associated with activation of renal AMPK and inhibition of renal tubular ENaC.	Caffeine	8-16	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	208-212
26909742-0	2016	Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).	Caffeine	45-53	thrombospondin 1	Homo sapiens	118-134
27012312-0	2016	Caffeine Mitigates the Locomotor Hyperactivity in Middle-aged Low-density Lipoprotein Receptor (LDLr)-Knockout Mice.	Caffeine	0-8	low density lipoprotein receptor	Mus musculus	62-94
27012312-0	2016	Caffeine Mitigates the Locomotor Hyperactivity in Middle-aged Low-density Lipoprotein Receptor (LDLr)-Knockout Mice.	Caffeine	0-8	low density lipoprotein receptor	Mus musculus	96-100
26909742-7	2016	Caffeine and theophylline inhibited the TSP-1/TSP-1 receptor mechanism by inhibiting LRP1 expression.	Caffeine	0-8	thrombospondin 1	Homo sapiens	40-45
26909742-7	2016	Caffeine and theophylline inhibited the TSP-1/TSP-1 receptor mechanism by inhibiting LRP1 expression.	Caffeine	0-8	thrombospondin 1	Homo sapiens	46-51
26909742-7	2016	Caffeine and theophylline inhibited the TSP-1/TSP-1 receptor mechanism by inhibiting LRP1 expression.	Caffeine	0-8	LDL receptor related protein 1	Homo sapiens	85-89
26961818-6	2016	The results suggested that, compared with observed clinical data, changes in systemic exposure to multiple CYP substrates by anti-IL-6 treatment in virtual RA patients have been reasonably captured by the PBPK model, as manifested by modulations in area under plasma concentration versus time curves for midazolam, omeprazole, S-warfarin, and caffeine.	Caffeine	343-351	interleukin 6	Homo sapiens	130-134
27127017-9	2016	The primary end points are: in vivo clearance of CYP3A4, CYP2E1 and CYP1A2 substrates, which will be defined by using well-tested probes; midazolam, chlorzoxazone and caffeine.	Caffeine	167-175	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
27127017-9	2016	The primary end points are: in vivo clearance of CYP3A4, CYP2E1 and CYP1A2 substrates, which will be defined by using well-tested probes; midazolam, chlorzoxazone and caffeine.	Caffeine	167-175	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74
26909742-0	2016	Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).	Caffeine	45-53	thrombospondin 1	Homo sapiens	136-141
26909742-4	2016	Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1).	Caffeine	26-34	thrombospondin 1	Homo sapiens	124-140
26909742-4	2016	Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1).	Caffeine	26-34	thrombospondin 1	Homo sapiens	142-147
26909742-4	2016	Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1).	Caffeine	26-34	LDL receptor related protein 1	Homo sapiens	167-217
26909742-4	2016	Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1).	Caffeine	26-34	LDL receptor related protein 1	Homo sapiens	219-223
26965143-5	2016	Specifically, either inhibition of ATM with caffeine or mutation of p53 (serine 15 to alanine) restored MDM2-dependent polyubiquitination of otherwise monoubiquitinated mutant p53.	Caffeine	44-52	ATM serine/threonine kinase	Homo sapiens	35-38
26965143-5	2016	Specifically, either inhibition of ATM with caffeine or mutation of p53 (serine 15 to alanine) restored MDM2-dependent polyubiquitination of otherwise monoubiquitinated mutant p53.	Caffeine	44-52	MDM2 proto-oncogene	Homo sapiens	104-108
26965143-5	2016	Specifically, either inhibition of ATM with caffeine or mutation of p53 (serine 15 to alanine) restored MDM2-dependent polyubiquitination of otherwise monoubiquitinated mutant p53.	Caffeine	44-52	tumor protein p53	Homo sapiens	176-179
26965143-6	2016	Caffeine treatment rescued MDM2-dependent proteasome degradation of mutant p53 in cells exhibiting active DNA damage signaling, and ATM knockdown phenocopied the caffeine effect.	Caffeine	0-8	MDM2 proto-oncogene	Homo sapiens	27-31
26965143-6	2016	Caffeine treatment rescued MDM2-dependent proteasome degradation of mutant p53 in cells exhibiting active DNA damage signaling, and ATM knockdown phenocopied the caffeine effect.	Caffeine	0-8	tumor protein p53	Homo sapiens	75-78
26965143-6	2016	Caffeine treatment rescued MDM2-dependent proteasome degradation of mutant p53 in cells exhibiting active DNA damage signaling, and ATM knockdown phenocopied the caffeine effect.	Caffeine	162-170	ATM serine/threonine kinase	Homo sapiens	132-135
26862045-1	2016	The salivary paraxanthine/caffeine molar ratio has been proposed as a novel dynamic liver function test to guide dose adjustments of drugs hepatically cleared by CYP1A2.	Caffeine	26-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	162-168
26974211-5	2016	Interestingly, when MII oocytes were exposed to caffeine, the decline of SIRT1, 2, 3 mRNA levels was delayed and the aging-associated defective phenotypes could be improved.	Caffeine	48-56	sirtuin 1	Mus musculus	73-78
26773691-9	2016	The alveolar bone mineral density and bone volume fraction were similar between the two groups; however, immunohistochemical staining showed that the caffeine group had significantly more TRAP(+) osteoclasts and higher RANKL expression in the compressed periodontium.	Caffeine	150-158	TNF superfamily member 11	Rattus norvegicus	219-224
26773691-10	2016	(2) In vitro, caffeine at 0.01mM significantly enhanced the compression-induced expression of RANKL and COX-2, as well as prostaglandin E2 production in the PDLtm.	Caffeine	14-22	TNF superfamily member 11	Rattus norvegicus	94-99
26773691-10	2016	(2) In vitro, caffeine at 0.01mM significantly enhanced the compression-induced expression of RANKL and COX-2, as well as prostaglandin E2 production in the PDLtm.	Caffeine	14-22	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	104-109
26874560-10	2016	Adolescent caffeine consumption elevated plasma CORT 24h after initiation of caffeine consumption that normalized over the course of the 28-day consumption procedure.	Caffeine	11-19	cortistatin	Rattus norvegicus	48-52
26874560-10	2016	Adolescent caffeine consumption elevated plasma CORT 24h after initiation of caffeine consumption that normalized over the course of the 28-day consumption procedure.	Caffeine	77-85	cortistatin	Rattus norvegicus	48-52
26874560-11	2016	CORT levels were also elevated 24h after caffeine removal and remained elevated for 7 days.	Caffeine	41-49	cortistatin	Rattus norvegicus	0-4
26874560-14	2016	Adolescent caffeine consumption increased basal c-fos mRNA in the paraventricular nucleus of the hypothalamus.	Caffeine	11-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
27015556-8	2016	Combination treatment of caffeine, which increases BCL6 expression in ALL cells, with chemotherapy extended the event free survival of mice.	Caffeine	25-33	B cell leukemia/lymphoma 6	Mus musculus	51-55
26774980-5	2016	Recognition memory was impaired only in female rats receiving caffeine (0.3 and 1.0 g/L) during development, coincident with increased proBDNF and unchanged BDNF levels in the hippocampus.	Caffeine	62-70	brain-derived neurotrophic factor	Rattus norvegicus	138-142
26774980-7	2016	Both caffeine treatment regimens decreased GFAP (as an astrocyte marker) and SNAP-25 (as a nerve terminals marker) in the hippocampus from male rats.	Caffeine	5-13	glial fibrillary acidic protein	Rattus norvegicus	43-47
26774980-7	2016	Both caffeine treatment regimens decreased GFAP (as an astrocyte marker) and SNAP-25 (as a nerve terminals marker) in the hippocampus from male rats.	Caffeine	5-13	synaptosome associated protein 25	Rattus norvegicus	77-84
26774980-9	2016	These findings revealed that caffeine intake during a specific time window of brain development promotes sex-dependent behavioral outcomes related to modification in BDNF signaling.	Caffeine	29-37	brain-derived neurotrophic factor	Rattus norvegicus	166-170
27173183-1	2016	The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial.	Caffeine	132-140	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-126
27173183-8	2016	Our data highlight the need to test other CYP1A2 polymorphisms showing significance in genome-wide association studies to clarify the association with caffeine intake in the Asian population.	Caffeine	151-159	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
26182441-8	2016	RESULTS: Average SPR times were faster during CAF than PLA during SPR 1 and SPR 2 (P = .037 and .016).	Caffeine	46-49	psoriasis susceptibility 1 candidate 2	Homo sapiens	66-71
26853314-2	2016	The phase transition of a model API, caffeine Form I (CFI), was studied during direct compression process by analysing the impacts of the operating conditions (process and formulation).	Caffeine	37-45	complement factor I	Homo sapiens	54-57
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	nitric oxide synthase 2, inducible	Mus musculus	84-115
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	nitric oxide synthase 2, inducible	Mus musculus	117-121
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	124-140
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	142-147
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	interleukin 3	Mus musculus	150-168
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	interleukin 6	Mus musculus	170-174
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	interleukin 6	Mus musculus	205-209
26852703-5	2016	Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264.7 cells.	Caffeine	0-8	mitogen-activated protein kinase 14	Mus musculus	239-246
26786159-10	2016	Conversely, we rescued pacemaker activity in Cav1.3(-/-) SAN cells and intact tissues through caffeine-mediated stimulation of Ca(2+)-induced Ca(2+) release.	Caffeine	94-102	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	45-51
27136008-12	2016	1 caffeine administered at or above 12.5 mg/(kg BW d) induced severe PHS and resulted in acute mortality and RVH ( &lt; 0.05).	Caffeine	2-10	SMU1 DNA replication regulator and spliceosomal factor	Homo sapiens	48-52
26826282-1	2016	Low and high-temperature phases of anhydrous caffeine: Spectroscopic ((1)H-(14)N NMR-NQR/(14)N NQR) and solid-state computational modelling (DFT/QTAIM/RDS) study.	Caffeine	45-53	peripherin 2	Homo sapiens	151-154
26826282-9	2016	Substantial differences in the intermolecular interaction phases I and II of caffeine were analysed using computational (DFT/QTAIM/RDS) approach.	Caffeine	77-85	peripherin 2	Homo sapiens	131-134
27008631-6	2016	Additionally, diabetes duration modified both of the positive associations of tumor necrosis factor-alpha levels (both interactions p&lt;=0.01) with mean glycemic control during the previous 10 years (significant only in women with longer durations) and current daily caffeine intake (significant only in women with shorter durations).	Caffeine	268-276	tumor necrosis factor	Homo sapiens	78-105
26182441-8	2016	RESULTS: Average SPR times were faster during CAF than PLA during SPR 1 and SPR 2 (P = .037 and .016).	Caffeine	46-49	Sp3 transcription factor	Homo sapiens	76-81
26350746-3	2016	Anti-adipogenic markers, such as preadipocyte secreted factor (Pref)-1 and Kruppel-like factor 2, remained to be expressed in the presence of caffeine.	Caffeine	142-150	delta like non-canonical Notch ligand 1	Mus musculus	33-70
26620258-0	2016	Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against beta-amyloid-induced alterations in red blood cells.	Caffeine	85-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
26620258-0	2016	Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against beta-amyloid-induced alterations in red blood cells.	Caffeine	85-93	proline rich transmembrane protein 2	Homo sapiens	40-56
26767416-0	2016	Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1.	Caffeine	0-8	carbonic anhydrase 1	Rattus norvegicus	90-93
26767416-1	2016	We have investigated the neuroprotective effect of chronic caffeine treatment on basal levels of memory-related signaling molecules in area CA1 of sleep-deprived rats.	Caffeine	59-67	carbonic anhydrase 1	Rattus norvegicus	140-143
26449824-0	2016	Caffeine-induced nuclear translocation of FoxO1 triggers Bim-mediated apoptosis in human glioblastoma cells.	Caffeine	0-8	forkhead box O1	Homo sapiens	42-47
26449824-0	2016	Caffeine-induced nuclear translocation of FoxO1 triggers Bim-mediated apoptosis in human glioblastoma cells.	Caffeine	0-8	BCL2 like 11	Homo sapiens	57-60
26449824-5	2016	Western blotting was used to investigate the role played by FoxO1 in the proapoptotic effects of caffeine on glioma cells.	Caffeine	97-105	forkhead box O1	Homo sapiens	60-65
26449824-6	2016	Results showed that caffeine inhibited proliferation and survival of human glioma cells, induced apoptosis, and increased the expression of FoxO1 and its proapoptotic target Bim.	Caffeine	20-28	forkhead box O1	Homo sapiens	140-145
26449824-6	2016	Results showed that caffeine inhibited proliferation and survival of human glioma cells, induced apoptosis, and increased the expression of FoxO1 and its proapoptotic target Bim.	Caffeine	20-28	BCL2 like 11	Homo sapiens	174-177
26449824-8	2016	In summary, our data indicates that FoxO1-Bim mediates caffeine-induced regression of glioma growth by activating cell apoptosis, thereby providing new mechanistic insight into the possible use of caffeine in treating human cancer.	Caffeine	55-63	forkhead box O1	Homo sapiens	36-41
26449824-8	2016	In summary, our data indicates that FoxO1-Bim mediates caffeine-induced regression of glioma growth by activating cell apoptosis, thereby providing new mechanistic insight into the possible use of caffeine in treating human cancer.	Caffeine	55-63	BCL2 like 11	Homo sapiens	42-45
26449824-8	2016	In summary, our data indicates that FoxO1-Bim mediates caffeine-induced regression of glioma growth by activating cell apoptosis, thereby providing new mechanistic insight into the possible use of caffeine in treating human cancer.	Caffeine	197-205	forkhead box O1	Homo sapiens	36-41
26449824-8	2016	In summary, our data indicates that FoxO1-Bim mediates caffeine-induced regression of glioma growth by activating cell apoptosis, thereby providing new mechanistic insight into the possible use of caffeine in treating human cancer.	Caffeine	197-205	BCL2 like 11	Homo sapiens	42-45
26350746-0	2016	Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes.	Caffeine	0-8	thymoma viral proto-oncogene 1	Mus musculus	86-89
26350746-0	2016	Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes.	Caffeine	0-8	glycogen synthase kinase 3 beta	Mus musculus	90-94
26350746-2	2016	In this study, we demonstrated that caffeine suppressed 3T3-L1 adipocyte differentiation and inhibited the expression of CCAAT/enhancer binding protein (C/EBP)alpha and peroxisome proliferator-activated receptor (PPAR)gamma, two main adipogenic transcription factors.	Caffeine	36-44	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	153-164
26350746-5	2016	Investigation of hormonal signaling revealed that caffeine inhibited the activation of AKT and glycogen synthase kinase (GSK) 3 in a dose-dependent manner, but not extracellular signal-regulated kinase (ERK).	Caffeine	50-58	thymoma viral proto-oncogene 1	Mus musculus	87-90
26350746-6	2016	Our data show that caffeine is an anti-adipogenic bioactive compound involved in the modulation of mitotic clonal expansion during adipocyte differentiation through the AKT/GSK3 pathway.	Caffeine	19-27	thymoma viral proto-oncogene 1	Mus musculus	169-172
26350746-2	2016	In this study, we demonstrated that caffeine suppressed 3T3-L1 adipocyte differentiation and inhibited the expression of CCAAT/enhancer binding protein (C/EBP)alpha and peroxisome proliferator-activated receptor (PPAR)gamma, two main adipogenic transcription factors.	Caffeine	36-44	peroxisome proliferator activated receptor gamma	Mus musculus	213-223
26350746-6	2016	Our data show that caffeine is an anti-adipogenic bioactive compound involved in the modulation of mitotic clonal expansion during adipocyte differentiation through the AKT/GSK3 pathway.	Caffeine	19-27	glycogen synthase kinase 3 beta	Mus musculus	173-177
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	vascular endothelial growth factor A	Gallus gallus	82-86
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	kinase insert domain receptor	Gallus gallus	88-94
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	phosphatidylinositol glycan anchor biosynthesis class F	Gallus gallus	96-100
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	insulin like growth factor 2	Gallus gallus	102-106
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	neuropilin 1	Gallus gallus	111-115
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	angiopoietin 1	Gallus gallus	145-149
26179615-6	2016	Semi-quantitative RT-PCR analysis revealed that caffeine treatment down-regulated VEGF, VEGFR2, PIGF, IGF2 and NRP1 expression, but up-regulated Ang1 and Ang2 expression.	Caffeine	48-56	VPS51 subunit of GARP complex	Gallus gallus	154-158
28955844-8	2016	This was likely due to caffeine induced inhibition of phosphatidylinositol 3-kinase (PI3K), since nanomolar concentrations of wortmannin, a selective PI3K inhibitor, also inhibited glucose transport, and previous investigators have also found this action.	Caffeine	23-31	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	54-83
26132827-0	2016	Effects of Caffeine Supplementation on Plasma and Blood Mononuclear Cell Interleukin-10 Levels After Exercise.	Caffeine	11-19	interleukin 10	Homo sapiens	73-87
26683224-4	2016	Inhibition of the ATM/ATR activation with caffeine reverted GL-induced G2/M cell cycle arrest, apoptosis and DNA damage measured by fH2AX.	Caffeine	42-50	ATM serine/threonine kinase	Homo sapiens	18-21
26683224-4	2016	Inhibition of the ATM/ATR activation with caffeine reverted GL-induced G2/M cell cycle arrest, apoptosis and DNA damage measured by fH2AX.	Caffeine	42-50	ATR serine/threonine kinase	Homo sapiens	22-25
26616205-8	2016	Among seven xanthine derivatives tested at 50-300muM, caffeine, theobromine and acefylline proved to be the most potent enhancers of in vitro deimination of FLG by PAD1 and PAD3.	Caffeine	54-62	filaggrin	Homo sapiens	157-160
26616205-8	2016	Among seven xanthine derivatives tested at 50-300muM, caffeine, theobromine and acefylline proved to be the most potent enhancers of in vitro deimination of FLG by PAD1 and PAD3.	Caffeine	54-62	peptidyl arginine deiminase 1	Homo sapiens	164-168
26616205-8	2016	Among seven xanthine derivatives tested at 50-300muM, caffeine, theobromine and acefylline proved to be the most potent enhancers of in vitro deimination of FLG by PAD1 and PAD3.	Caffeine	54-62	peptidyl arginine deiminase 3	Homo sapiens	173-177
26743903-4	2016	We performed a comparative proteomic analysis to investigate the mode of action of high-dose caffeine treatment in C. elegans and found that the stress response proteins, heat shock protein (HSP)-4 (endoplasmic reticulum [ER] chaperone), HSP-6 (mitochondrial chaperone), and HSP-16 (cytosolic chaperone), were induced and their expression was regulated at the transcriptional level.	Caffeine	93-101	Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D	Caenorhabditis elegans	171-197
26743903-4	2016	We performed a comparative proteomic analysis to investigate the mode of action of high-dose caffeine treatment in C. elegans and found that the stress response proteins, heat shock protein (HSP)-4 (endoplasmic reticulum [ER] chaperone), HSP-6 (mitochondrial chaperone), and HSP-16 (cytosolic chaperone), were induced and their expression was regulated at the transcriptional level.	Caffeine	93-101	Heat shock protein hsp-6	Caenorhabditis elegans	238-243
26743903-7	2016	In addition, caffeine treatment stimulated a food-avoidance behavior (aversion phenotype), which was enhanced by RNAi depletion of the hsp-4 gene.	Caffeine	13-21	Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D	Caenorhabditis elegans	135-140
26727128-6	2016	Caffeine, which is an inhibitor of ataxia telangiectasia mutated protein (ATM) and ataxia telangiectasia mutated and Rad3-related protein (ATR), and the Chk1 inhibitor inhibited the TER increases induced by daunorubicin and rebeccamycin, whereas a Chk2 inhibitor did not.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	35-72
26727128-6	2016	Caffeine, which is an inhibitor of ataxia telangiectasia mutated protein (ATM) and ataxia telangiectasia mutated and Rad3-related protein (ATR), and the Chk1 inhibitor inhibited the TER increases induced by daunorubicin and rebeccamycin, whereas a Chk2 inhibitor did not.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	74-77
26727128-6	2016	Caffeine, which is an inhibitor of ataxia telangiectasia mutated protein (ATM) and ataxia telangiectasia mutated and Rad3-related protein (ATR), and the Chk1 inhibitor inhibited the TER increases induced by daunorubicin and rebeccamycin, whereas a Chk2 inhibitor did not.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	139-142
26727128-6	2016	Caffeine, which is an inhibitor of ataxia telangiectasia mutated protein (ATM) and ataxia telangiectasia mutated and Rad3-related protein (ATR), and the Chk1 inhibitor inhibited the TER increases induced by daunorubicin and rebeccamycin, whereas a Chk2 inhibitor did not.	Caffeine	0-8	checkpoint kinase 2	Homo sapiens	248-252
26735800-0	2016	Caffeine: Friend or Foe?	Caffeine	0-8	WAPL cohesin release factor	Homo sapiens	20-23
26588584-0	2016	Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	67-73
26588584-3	2016	This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM.	Caffeine	110-118	peptidylprolyl isomerase G	Homo sapiens	92-95
26588584-7	2016	CYP rs2470890 allele "C" increases the odds of T2DM by a factor of around 1.2 but decreases the odds of caffeine boosting T2DM of 1.7 by a factor of 0.77. rs2470890 showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome.	Caffeine	104-112	peptidylprolyl isomerase G	Homo sapiens	0-3
26998364-5	2016	A brief local puff-application of caffeine to hippocampal CA1 pyramidal cells transiently suppressed GABAergic inhibitory postsynaptic currents (IPSCs) by 73.2 +- 6.98%.	Caffeine	34-42	carbonic anhydrase 1	Homo sapiens	58-61
26194897-7	2016	The effect of Src inhibition was not observed in the presence of an ATM/ATR inhibitor caffeine.	Caffeine	86-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-17
26634797-8	2016	However, the expression of gene transcripts for alkaline phosphatase, Runx-2, and bone sialoprotein, as well as the synthesis of mineralization nodules, decreased significantly in all groups treated with caffeine.	Caffeine	204-212	RUNX family transcription factor 2	Rattus norvegicus	70-76
26634797-9	2016	The expression of osteocalcin was significantly reduced only in the group treated with 50 mg/kg caffeine.	Caffeine	96-104	bone gamma-carboxyglutamate protein	Rattus norvegicus	18-29
29238623-3	2016	The other drugs, including nicotine, alcohol, opiates, and perhaps caffeine can affect CARTp or CART mRNA levels.	Caffeine	67-75	CART prepropeptide	Homo sapiens	87-92
29238623-3	2016	The other drugs, including nicotine, alcohol, opiates, and perhaps caffeine can affect CARTp or CART mRNA levels.	Caffeine	67-75	CART prepropeptide	Homo sapiens	87-91
26495862-7	2016	Furthermore, serum levels of IGF-1, estradiol, and testosterone were also reduced by the dose of caffeine exposure.	Caffeine	97-105	insulin-like growth factor 1	Rattus norvegicus	29-34
25450226-1	2016	Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer"s disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models.	Caffeine	15-23	adenosine A2a receptor	Homo sapiens	41-63
25450226-1	2016	Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer"s disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models.	Caffeine	15-23	adenosine A2a receptor	Homo sapiens	65-69
27582327-8	2016	The activities of cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, xanthine oxidase (XO) and N-acetyltransferase 2 (NAT2) were assessed based on the urinary metabolic indices of caffeine and dextromethorphan, and the urinary excretion ratio of 6beta-hydroxycortisol to cortisol.	Caffeine	171-179	N-acetyltransferase 2	Homo sapiens	109-113
26136110-7	2016	Apoptosis markers such as DNA fragmentation and caspase-3 activity were also inhibited by 5 mM LC in caffeine-treated cells.	Caffeine	101-109	caspase 3	Homo sapiens	48-57
26231684-10	2016	WHAT IS KNOWN: Our previous studies showed that CeasIng Cpap At standarD criteriA (CICADA) significantly reduces CPAP time, oxygen requirements and caffeine use.	Caffeine	148-156	centromere protein J	Homo sapiens	56-60
26231684-10	2016	WHAT IS KNOWN: Our previous studies showed that CeasIng Cpap At standarD criteriA (CICADA) significantly reduces CPAP time, oxygen requirements and caffeine use.	Caffeine	148-156	centromere protein J	Homo sapiens	113-117
26442661-8	2016	Caffeine alone modified only nNOS.	Caffeine	0-8	nitric oxide synthase 1, neuronal	Mus musculus	29-33
26442661-11	2016	In this study, caffeine was shown to potentiate MDMA-induced dopamine neuron degeneration in substantia nigra pars compacta, astrogliosis, and TNF-alpha levels in caudate-putamen of adolescent mice.	Caffeine	15-23	tumor necrosis factor	Mus musculus	143-152
26319049-10	2016	Combined treatment of aripiprazole and caffeine resulted in a decrease in the number of c-Fos positive cells as compared to the group receiving aripiprazole alone.	Caffeine	39-47	FBJ osteosarcoma oncogene	Mus musculus	88-93
26481538-4	2015	CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	75-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
26959995-3	2016	The majority of the effects of caffeine are mainly mediated by the blockade of adenosine receptors, and the proved neuroprotective effects of caffeine in brain disorders have been mimicked by the blockade of adenosine A2A receptor (A2AR).	Caffeine	142-150	adenosine A2a receptor	Homo sapiens	208-230
26959995-3	2016	The majority of the effects of caffeine are mainly mediated by the blockade of adenosine receptors, and the proved neuroprotective effects of caffeine in brain disorders have been mimicked by the blockade of adenosine A2A receptor (A2AR).	Caffeine	142-150	adenosine A2a receptor	Homo sapiens	232-236
26959995-5	2016	Moreover, the control of microglia reactivity by blocking A2AR has been proposed to be the mechanism underlying the observed protective effects of caffeine.	Caffeine	147-155	adenosine A2a receptor	Homo sapiens	58-62
26649750-5	2015	In addition, by introducing ataxia-telangiectasia-mutated (ATM) kinase inhibitors caffeine and KU-60019, we displayed that Q6-triggered apoptosis was attributed, at least partially, to DNA double-strand breaks generated by the topo II-targeting effect.	Caffeine	82-90	ATM serine/threonine kinase	Homo sapiens	28-57
26649750-5	2015	In addition, by introducing ataxia-telangiectasia-mutated (ATM) kinase inhibitors caffeine and KU-60019, we displayed that Q6-triggered apoptosis was attributed, at least partially, to DNA double-strand breaks generated by the topo II-targeting effect.	Caffeine	82-90	ATM serine/threonine kinase	Homo sapiens	59-62
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	15-37
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	59-66
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	129-148
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	214-221
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	226-232
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	adenosine A2a receptor	Homo sapiens	15-37
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	adenosine A2a receptor	Homo sapiens	59-66
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	129-148
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	adenosine A2a receptor	Homo sapiens	214-221
28135712-2	2016	Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.	Caffeine	176-184	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	226-232
26510314-2	2015	Caffeine-encapsulated PLGA nanoparticles exhibited more pronounced increase in the endurance of dopaminergic neurons, fibre outgrowth and expression of tyrosine hydroxylase (TH) and growth-associated protein-43 (GAP-43) against 1-methyl-4-phenylpyridinium (MPP+)-induced alterations in vitro.	Caffeine	0-8	growth associated protein 43	Mus musculus	212-218
26510314-3	2015	Caffeine-encapsulated PLGA nanoparticles also inhibited MPP(+)-mediated nuclear translocation of nuclear factor-kappa B (NF-kappaB) and augmented protein kinase B phosphorylation more potentially than bulk counterpart.	Caffeine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-119
26510314-3	2015	Caffeine-encapsulated PLGA nanoparticles also inhibited MPP(+)-mediated nuclear translocation of nuclear factor-kappa B (NF-kappaB) and augmented protein kinase B phosphorylation more potentially than bulk counterpart.	Caffeine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
26510314-7	2015	The results thus suggest that nanotization improves the protective efficacy of caffeine against MPTP-induced Parkinsonism owing to enhanced bioavailability, inhibition of the nuclear translocation of NF-kappaB and activation of protein kinase B phosphorylation.	Caffeine	79-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	200-209
26817278-9	2015	The transient Ca2+ release was characterized in cardiomyocytes treated with/without 10 mmol/L caffeine and 8 mmol/L Ca2+.	Caffeine	94-102	carbonic anhydrase 2	Mus musculus	14-17
26817278-13	2015	Furthermore, ICA-induced JP2 expression was accompanied by a remarkable increase of the amplitude of Ca2+ transients in cardiomyocytes before/after caffeine and Ca2+ stimulating.	Caffeine	148-156	junctophilin 2	Mus musculus	25-28
26481538-4	2015	CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4).	Caffeine	75-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-54
26492550-5	2015	In addition, we expose zebrafish to caffeine, a positive control for c-fos activation in the brain.	Caffeine	36-44	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	69-74
26492550-8	2015	Our analysis showed that exposure to caffeine increased the number of c-fos protein-positive cells in specific zebrafish brain regions detected by the immunofluorescence method.	Caffeine	37-45	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	70-75
26619284-7	2015	The case is especially strong for Cyp12d1, with multiple lines of evidence indicating the gene causally impacts caffeine resistance.	Caffeine	112-120	Cyp12d1-p	Drosophila melanogaster	34-41
26619284-8	2015	Cyp12d1 is implicated by QTL mapped in both panels of DSPR RILs, is significantly upregulated in the presence of caffeine, and RNAi knockdown robustly decreases caffeine tolerance.	Caffeine	113-121	Cyp12d1-p	Drosophila melanogaster	0-7
26619284-8	2015	Cyp12d1 is implicated by QTL mapped in both panels of DSPR RILs, is significantly upregulated in the presence of caffeine, and RNAi knockdown robustly decreases caffeine tolerance.	Caffeine	161-169	Cyp12d1-p	Drosophila melanogaster	0-7
26560700-7	2015	Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels.	Caffeine	13-21	BCL2-associated X protein	Mus musculus	116-119
26367767-0	2015	Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism.	Caffeine	9-17	leptin	Homo sapiens	64-70
26367767-2	2015	This study aimed to investigate the decreased fetal blood leptin level by prenatal caffeine exposure (PCE) and its underlying placental mechanisms.	Caffeine	83-91	leptin	Homo sapiens	58-64
26367767-5	2015	Furthermore, we investigated the molecular mechanism of the reduced placental leptin"s expression by treatment with caffeine (0.8-20 muM) in the BeWo cells.	Caffeine	116-124	leptin	Homo sapiens	78-84
26367767-6	2015	In vivo, PCE significantly decreased fetal serum leptin level in caffeine dose-dependent manner.	Caffeine	65-73	leptin	Homo sapiens	49-55
26367767-8	2015	In vitro, caffeine significantly decreased the mRNA expression of leptin, CREB and ADORA2A in concentration and time-dependent manners.	Caffeine	10-18	leptin	Homo sapiens	66-72
26367767-8	2015	In vitro, caffeine significantly decreased the mRNA expression of leptin, CREB and ADORA2A in concentration and time-dependent manners.	Caffeine	10-18	cAMP responsive element binding protein 1	Homo sapiens	74-78
26367767-8	2015	In vitro, caffeine significantly decreased the mRNA expression of leptin, CREB and ADORA2A in concentration and time-dependent manners.	Caffeine	10-18	adenosine A2a receptor	Homo sapiens	83-90
26367767-9	2015	The addition of ADORA2A agonist or adenylyl cyclase (AC) agonist reversed the inhibition of leptin expression induced by caffeine.	Caffeine	121-129	adenosine A2a receptor	Homo sapiens	16-23
26367767-9	2015	The addition of ADORA2A agonist or adenylyl cyclase (AC) agonist reversed the inhibition of leptin expression induced by caffeine.	Caffeine	121-129	leptin	Homo sapiens	92-98
26367767-10	2015	PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.	Caffeine	85-93	leptin	Homo sapiens	41-47
26367767-10	2015	PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.	Caffeine	85-93	adenosine A2a receptor	Homo sapiens	116-123
26367767-10	2015	PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.	Caffeine	85-93	cAMP responsive element binding protein 1	Homo sapiens	229-233
26367767-10	2015	PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.	Caffeine	85-93	leptin	Homo sapiens	250-256
26572131-9	2015	Moreover, caffeine treatment was associated with upregulation of lipid beta-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1).	Caffeine	10-18	heat shock protein 5	Danio rerio	226-229
26572131-9	2015	Moreover, caffeine treatment was associated with upregulation of lipid beta-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1).	Caffeine	10-18	interleukin 1, beta	Danio rerio	265-273
26572131-10	2015	Protein expression of CHOP, BIP and IL-1beta remarkably reduced in caffeine treatment group compared with model group.	Caffeine	67-75	DNA-damage-inducible transcript 3	Danio rerio	22-26
26572131-10	2015	Protein expression of CHOP, BIP and IL-1beta remarkably reduced in caffeine treatment group compared with model group.	Caffeine	67-75	heat shock protein 5	Danio rerio	28-31
26572131-10	2015	Protein expression of CHOP, BIP and IL-1beta remarkably reduced in caffeine treatment group compared with model group.	Caffeine	67-75	interleukin 1, beta	Danio rerio	36-44
26560700-7	2015	Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels.	Caffeine	13-21	adenosine A1 receptor	Mus musculus	154-175
26521794-0	2015	Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis.	Caffeine	0-8	checkpoint kinase 2	Homo sapiens	136-140
26521794-0	2015	Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis.	Caffeine	0-8	tumor protein p53	Homo sapiens	141-144
26521794-1	2015	BACKGROUND: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.	Caffeine	12-20	ATM serine/threonine kinase	Homo sapiens	106-109
26521794-1	2015	BACKGROUND: Caffeine suppresses ataxia telangiectasia and Rad3 related and ataxia telangiectasia mutated (ATM) activities; ATM is the major kinase for DNA damage detection.	Caffeine	12-20	ATM serine/threonine kinase	Homo sapiens	123-126
26521794-5	2015	Western blotting was used to investigate the effects of caffeine pretreatment on the ATM-Chk2-p53-Puma axis, while real-time polymerase chain reaction (RT-PCR) assessed changes in messenger RNA levels of p53 and downstream targets responding to IR.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	85-88
26521794-5	2015	Western blotting was used to investigate the effects of caffeine pretreatment on the ATM-Chk2-p53-Puma axis, while real-time polymerase chain reaction (RT-PCR) assessed changes in messenger RNA levels of p53 and downstream targets responding to IR.	Caffeine	56-64	checkpoint kinase 2	Homo sapiens	89-93
26521794-9	2015	RESULTS: Immunofluorescent staining showed that caffeine pretreatment profoundly suppressed the formation of gammaH2AXand p53-binding protein 1 foci in RT4 cells in response to irradiation.	Caffeine	48-56	tumor protein p53 binding protein 1	Homo sapiens	122-143
26521794-11	2015	RT-PCR indicated caffeine also attenuated transactivation of p53 and p53-inducible genes.	Caffeine	17-25	tumor protein p53	Homo sapiens	61-64
26521794-11	2015	RT-PCR indicated caffeine also attenuated transactivation of p53 and p53-inducible genes.	Caffeine	17-25	tumor protein p53	Homo sapiens	69-72
26521794-13	2015	CONCLUSION: Caffeine may inhibit IR-related apoptosis of bladder cancer RT4 cells by suppressing activation of the ATM-Chk2-p53-Puma axis.	Caffeine	12-20	ATM serine/threonine kinase	Homo sapiens	115-118
26521794-13	2015	CONCLUSION: Caffeine may inhibit IR-related apoptosis of bladder cancer RT4 cells by suppressing activation of the ATM-Chk2-p53-Puma axis.	Caffeine	12-20	checkpoint kinase 2	Homo sapiens	119-123
26521794-13	2015	CONCLUSION: Caffeine may inhibit IR-related apoptosis of bladder cancer RT4 cells by suppressing activation of the ATM-Chk2-p53-Puma axis.	Caffeine	12-20	tumor protein p53	Homo sapiens	124-127
25874477-9	2015	Importantly, our model also predicts that: (1) moderate RyR sensitization induces slow Ca(2+) oscillations, a result experimentally confirmed with low concentrations of caffeine; and (2) high RyR sensitization suppresses fast, agonist-induced Ca(2+) oscillations by inducing substantial store-operated Ca(2+) entry and elevated [Ca(2+)]i.	Caffeine	169-177	ryanodine receptor 1, skeletal muscle	Mus musculus	56-59
26556501-6	2015	Caffeine, which is an ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia and Rad3-related protein) kinase inhibitor, and KU55933, which is an ATM kinase inhibitor, were equally effective in rescuing the etoposide-induced cell-cycle blocks.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	62-65
26556501-6	2015	Caffeine, which is an ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia and Rad3-related protein) kinase inhibitor, and KU55933, which is an ATM kinase inhibitor, were equally effective in rescuing the etoposide-induced cell-cycle blocks.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	22-25
25891161-0	2015	Development and validation of a reversed-phase HPLC method for CYP1A2 phenotyping by use of a caffeine metabolite ratio in saliva.	Caffeine	94-102	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69
26255702-3	2015	Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus.	Caffeine	0-8	synaptophysin	Rattus norvegicus	63-76
26255702-3	2015	Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus.	Caffeine	0-8	synapsin I	Rattus norvegicus	81-91
26296573-0	2015	Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	89-111
26296573-2	2015	The main pharmacological effects of caffeine are mediated by antagonism of the adenosine receptor, A2AR.	Caffeine	36-44	adenosine A2a receptor	Mus musculus	99-103
26296573-3	2015	Here, we examine whether the targeting of A2AR by caffeine plays a role in anti-tumor immunity.	Caffeine	50-58	adenosine A2a receptor	Mus musculus	42-46
25297344-5	2015	RESULTS: Maximal HR (HRmax) was greater with caffeine (192 +- 2 vs. 190 +- 2 beat min(-1), p &lt; 0.05).	Caffeine	45-53	CD59 molecule (CD59 blood group)	Homo sapiens	82-88
26254047-7	2015	The partial inhibition of TRPP2 expression increased both the caffeine-evoked Ca(2+) responses and in vivo contraction.	Caffeine	62-70	polycystin 2, transient receptor potential cation channel	Mus musculus	26-31
26384306-0	2015	Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	116-120
26449851-6	2015	Chronic caffeine treatment prevented the reductions in the basal levels of P-CREB, total CREB and CaMKIV in sleep-deprived rats.	Caffeine	8-16	cAMP responsive element binding protein 1	Rattus norvegicus	77-81
26449851-6	2015	Chronic caffeine treatment prevented the reductions in the basal levels of P-CREB, total CREB and CaMKIV in sleep-deprived rats.	Caffeine	8-16	cAMP responsive element binding protein 1	Rattus norvegicus	89-93
26449851-6	2015	Chronic caffeine treatment prevented the reductions in the basal levels of P-CREB, total CREB and CaMKIV in sleep-deprived rats.	Caffeine	8-16	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	98-104
26449851-7	2015	Furthermore, caffeine prevented post-L-LTP sleep deprivation-induced downregulation of P-CREB and brain-derived neurotrophic factor in the DG.	Caffeine	13-21	cAMP responsive element binding protein 1	Rattus norvegicus	89-93
26449851-7	2015	Furthermore, caffeine prevented post-L-LTP sleep deprivation-induced downregulation of P-CREB and brain-derived neurotrophic factor in the DG.	Caffeine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	98-131
26209154-6	2015	We observed that chronic treatment of caffeine (3 mg/kg/day intraperitoneally (i.p) for 60 days) improved memory impairment and synaptic markers (Synaptophysin and PSD95) in the d-galactose treated rats.	Caffeine	38-46	synaptophysin	Rattus norvegicus	146-159
26209154-6	2015	We observed that chronic treatment of caffeine (3 mg/kg/day intraperitoneally (i.p) for 60 days) improved memory impairment and synaptic markers (Synaptophysin and PSD95) in the d-galactose treated rats.	Caffeine	38-46	discs large MAGUK scaffold protein 4	Rattus norvegicus	164-169
26209154-8	2015	Consequently caffeine treatment suppressed stress kinases p-JNK.	Caffeine	13-21	mitogen-activated protein kinase 8	Rattus norvegicus	60-63
26209154-9	2015	Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta.	Caffeine	14-22	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	120-125
26209154-9	2015	Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta.	Caffeine	14-22	nitric oxide synthase 2	Rattus norvegicus	127-132
26209154-9	2015	Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta.	Caffeine	14-22	tumor necrosis factor	Rattus norvegicus	134-142
26209154-9	2015	Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta.	Caffeine	14-22	interleukin 1 beta	Rattus norvegicus	147-155
26209154-10	2015	Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level.	Caffeine	34-42	BCL2 associated X, apoptosis regulator	Rattus norvegicus	65-68
26209154-10	2015	Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level.	Caffeine	34-42	BCL2, apoptosis regulator	Rattus norvegicus	69-73
26209154-10	2015	Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level.	Caffeine	34-42	caspase 9	Rattus norvegicus	81-90
26209154-10	2015	Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level.	Caffeine	34-42	caspase 3	Rattus norvegicus	92-101
26209154-10	2015	Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level.	Caffeine	34-42	poly (ADP-ribose) polymerase 1	Rattus norvegicus	106-112
26452792-1	2015	Caffeine is the probe drug of choice to assess the phenotype of the drug metabolizing enzyme CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99
26452792-17	2015	The optimized and validated method for determination of caffeine and paraxanthine in hair proved to be reliable and may serve to evaluate the potential of hair analysis for CYP1A2 phenotyping.	Caffeine	56-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	173-179
26384306-5	2015	Unmodified caffeine downregulated mTOR signalling, which affected glycolysis and the release of pro-inflammatory/pro-angiogenic cytokines as well as other inflammatory mediators.	Caffeine	11-19	mechanistic target of rapamycin kinase	Homo sapiens	34-38
26384306-7	2015	In basophils, caffeine also increased intracellular cyclic adenosine monophosphate (cAMP) levels which further enhanced its inhibitory action on mTOR.	Caffeine	14-22	mechanistic target of rapamycin kinase	Homo sapiens	145-149
26471759-6	2015	In contrast, caffeine inhibited basal and contraction-stimulated Akt Ser(473) phosphorylation.	Caffeine	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
26239303-6	2015	Downregulated N-acetyltransferase (NAT)1 and NAT2 were enriched in the caffeine metabolism pathway.	Caffeine	71-79	N-acetyltransferase 2	Homo sapiens	45-49
24867603-13	2015	Moreover, moderate and high doses of caffeine attenuate the insulin responses.	Caffeine	37-45	insulin	Homo sapiens	60-67
26087403-6	2015	Comparison of the effects of three chemicals, dBIQdO, aphidicolin and caffeine, on IE1 localization allowed us to detect a shift from focal distribution to VS localization, suggesting that IE1 foci are disassembled prior to VS formation.	Caffeine	70-78	IE-1	Bombyx mori nucleopolyhedrovirus	83-86
26087403-6	2015	Comparison of the effects of three chemicals, dBIQdO, aphidicolin and caffeine, on IE1 localization allowed us to detect a shift from focal distribution to VS localization, suggesting that IE1 foci are disassembled prior to VS formation.	Caffeine	70-78	IE-1	Bombyx mori nucleopolyhedrovirus	189-192
26192006-2	2015	Because NAT2 is involved in caffeine metabolism, we aimed to determine whether caffeine consumption is associated with SIF and whether rs1495741 is associated with SIF independently of caffeine.	Caffeine	28-36	N-acetyltransferase 2	Homo sapiens	8-12
26348183-1	2015	OBJECTIVE: To measure the association between second-trimester maternal caffeine intake and caffeine metabolism through the CYP1A2 system and the risk of subsequent severe preeclampsia.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
26348183-1	2015	OBJECTIVE: To measure the association between second-trimester maternal caffeine intake and caffeine metabolism through the CYP1A2 system and the risk of subsequent severe preeclampsia.	Caffeine	92-100	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
26471759-12	2015	Caffeine also inhibited basal and contraction-stimulated Akt phosphorylation in vivo.	Caffeine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
26366127-0	2015	Complex Behavior of Caffeine Crystallites on Muscovite Mica Surfaces.	Caffeine	20-28	MHC class I polypeptide-related sequence A	Homo sapiens	55-59
26243374-8	2015	Overall, sample"s patients demonstrated significant increases in ACTH, cortisol, and DHEAS plasma levels after caffeine administration.	Caffeine	111-119	proopiomelanocortin	Homo sapiens	65-69
26243374-10	2015	Our results indicate that in PD patients, caffeine-induced panic attacks are not specifically associated with HPA-axis activation, as this is reflected in post-caffeine increases in ACTH, cortisol and DHEAS plasma levels, suggesting that caffeine-induced panic attacks in PD patients are not specifically mediated by the biological processes underlying fear or stress.	Caffeine	42-50	proopiomelanocortin	Homo sapiens	182-186
25719307-10	2015	A study in Danish mono and dizygotic twins showed that the non-polymorphic 3-N-demethylation of caffeine catalyzed by CYP1A2 is subject to approximately 70% genetic control.	Caffeine	96-104	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124
27280235-0	2015	Effect of taurine and caffeine on plasma c-reactive protein and calcium in Wistar rats.	Caffeine	22-30	C-reactive protein	Rattus norvegicus	41-59
27280235-4	2015	There is paucity of information on the effect of the combined administration of taurine and caffeine on C-reactive protein (CRP)--a marker of inflammation and plasma calcium level in rats.	Caffeine	92-100	C-reactive protein	Rattus norvegicus	104-122
27280235-4	2015	There is paucity of information on the effect of the combined administration of taurine and caffeine on C-reactive protein (CRP)--a marker of inflammation and plasma calcium level in rats.	Caffeine	92-100	C-reactive protein	Rattus norvegicus	124-127
27280235-5	2015	AIM: The present study was designed to investigate the effects of combined taurine and caffeine on the plasma level of CRP, Ca2+ as well as the effect of nifedipine on calcium level.	Caffeine	87-95	C-reactive protein	Rattus norvegicus	119-122
27280235-10	2015	RESULTS: The results showed that CRP was significantly decreased in five of the treated groups compared with the control with the exception of the group treated with taurine alone (Group 2), and that treated with combined taurine and caffeine (Group 6).	Caffeine	234-242	C-reactive protein	Rattus norvegicus	33-36
27280235-13	2015	CONCLUSION: The results have shown that combined caffeine and taurine can boost plasma calcium level and decrease plasma CRP level.	Caffeine	49-57	C-reactive protein	Rattus norvegicus	121-124
26132720-5	2015	NAC treatment of CASQ1-null muscles/mice normalized caffeine sensitivity during in vitro contracture tests, Ca transients in single fibers, and significantly reduced the percentage of fibers undergoing rhabdomyolysis (37.6 +- 2.5%, 38/101 fibers in 3 mice; 11.6 +- 1.1%, 21/186 fibers in 5 mice).	Caffeine	52-60	calsequestrin 1	Mus musculus	17-22
25986755-0	2015	Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure.	Caffeine	136-144	angiotensin II receptor, type 2	Rattus norvegicus	36-40
26400523-9	2015	Furthermore, caffeine induced cell apoptosis, decreased expression of Bcl-2, and increased expression of Cyt-C and Caspase-3.	Caffeine	13-21	BCL2 apoptosis regulator	Homo sapiens	70-75
26400523-9	2015	Furthermore, caffeine induced cell apoptosis, decreased expression of Bcl-2, and increased expression of Cyt-C and Caspase-3.	Caffeine	13-21	caspase 3	Homo sapiens	115-124
26019181-0	2015	Caffeine inhibits gene conversion by displacing Rad51 from ssDNA.	Caffeine	0-8	RAD51 recombinase	Homo sapiens	48-53
26047722-3	2015	We studied theophylline and caffeine effects on ENOs in CA3 neurons (CA3-ENOs) and CA3 electrical stimulation-evoked monosynaptic CA1 field potentials (CA1-FPs) in sliced and intact hippocampi, respectively, from 8 to 10-days-old rats.	Caffeine	28-36	carbonic anhydrase 3	Rattus norvegicus	56-59
26019182-6	2015	Caffeine treatment led to the rapid loss, by proteasomal degradation, of both Sae2, a nuclease that plays a role in early steps of resection, and Dna2, a nuclease that facilitates one of two extensive resection pathways.	Caffeine	0-8	RB binding protein 8, endonuclease	Homo sapiens	78-82
26019182-6	2015	Caffeine treatment led to the rapid loss, by proteasomal degradation, of both Sae2, a nuclease that plays a role in early steps of resection, and Dna2, a nuclease that facilitates one of two extensive resection pathways.	Caffeine	0-8	DNA replication helicase/nuclease 2	Homo sapiens	146-150
26019182-9	2015	Caffeine treatment had similar effects on irradiated HeLa cells, blocking the formation of RPA and Rad51 foci that depend on 5" to 3" resection of broken chromosome ends.	Caffeine	0-8	RAD51 recombinase	Homo sapiens	99-104
26291453-7	2015	Inhibiting Rab10 activity by pan-neuronal expression of a dominant-negative Rab10 mutant in Drosophila melanogaster decreased methamphetamine-induced activity and mortality and decreased caffeine-stimulated activity but not mortality, whereas inhibiting Rab10 activity selectively in cholinergic neurons had no effect.	Caffeine	187-195	Rab10	Drosophila melanogaster	11-16
26291453-7	2015	Inhibiting Rab10 activity by pan-neuronal expression of a dominant-negative Rab10 mutant in Drosophila melanogaster decreased methamphetamine-induced activity and mortality and decreased caffeine-stimulated activity but not mortality, whereas inhibiting Rab10 activity selectively in cholinergic neurons had no effect.	Caffeine	187-195	Rab10	Drosophila melanogaster	76-81
26291453-7	2015	Inhibiting Rab10 activity by pan-neuronal expression of a dominant-negative Rab10 mutant in Drosophila melanogaster decreased methamphetamine-induced activity and mortality and decreased caffeine-stimulated activity but not mortality, whereas inhibiting Rab10 activity selectively in cholinergic neurons had no effect.	Caffeine	187-195	Rab10	Drosophila melanogaster	76-81
26277840-0	2015	Chronic fetal exposure to caffeine altered resistance vessel functions via RyRs-BKCa down-regulation in rat offspring.	Caffeine	26-34	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	80-84
26277840-8	2015	BKCa alpha-subunit expression was unchanged, BKCa beta1-subunit and sensitivity of BKCa to tamoxifen were reduced in the caffeine offspring as altered biophysical properties of BKCa in the MA.	Caffeine	121-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	45-49
26277840-8	2015	BKCa alpha-subunit expression was unchanged, BKCa beta1-subunit and sensitivity of BKCa to tamoxifen were reduced in the caffeine offspring as altered biophysical properties of BKCa in the MA.	Caffeine	121-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	45-49
26277840-8	2015	BKCa alpha-subunit expression was unchanged, BKCa beta1-subunit and sensitivity of BKCa to tamoxifen were reduced in the caffeine offspring as altered biophysical properties of BKCa in the MA.	Caffeine	121-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	45-49
26277840-11	2015	The results suggest that the altered STOCs activity in the caffeine offspring could attribute to down-regulation of RyRs-BKCa, providing new information for further understanding increased risks of hypertension in developmental origins.	Caffeine	59-67	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	121-125
26019181-3	2015	Recently caffeine treatment has been shown to prevent gene targeting in mammalian cells by increasing non-productive Rad51 interactions between the DSB and random regions of the genome.	Caffeine	9-17	RAD51 recombinase	Homo sapiens	117-122
26019181-4	2015	Here we show that caffeine treatment prevents gene conversion in yeast, independently of its inhibition of the Mec1(ATR)/Tel1(ATM)-dependent DNA damage response or caffeine"s inhibition of 5" to 3" resection of DSB ends.	Caffeine	18-26	protein kinase MEC1	Saccharomyces cerevisiae S288C	111-115
26019181-4	2015	Here we show that caffeine treatment prevents gene conversion in yeast, independently of its inhibition of the Mec1(ATR)/Tel1(ATM)-dependent DNA damage response or caffeine"s inhibition of 5" to 3" resection of DSB ends.	Caffeine	18-26	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	121-125
26019181-5	2015	Caffeine treatment results in a dosage-dependent eviction of Rad51 from ssDNA.	Caffeine	0-8	RAD51 recombinase	Homo sapiens	61-66
26019181-8	2015	Caffeine treatment had similar effects on irradiated HeLa cells, promoting loss of previously assembled Rad51 foci.	Caffeine	0-8	RAD51 recombinase	Homo sapiens	104-109
26019181-9	2015	We conclude that caffeine treatment can disrupt gene conversion by disrupting Rad51 filaments.	Caffeine	17-25	RAD51 recombinase	Homo sapiens	78-83
26019182-0	2015	Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2.	Caffeine	0-8	RB binding protein 8, endonuclease	Homo sapiens	87-91
26019182-0	2015	Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2.	Caffeine	0-8	DNA replication helicase/nuclease 2	Homo sapiens	96-100
26019182-5	2015	Unexpectedly, caffeine treatment impaired homologous recombination by inhibiting 5" to 3" end resection, independent of Mec1 and Tel1 inhibition.	Caffeine	14-22	ATR serine/threonine kinase	Homo sapiens	120-124
25591953-7	2015	The skin location amount of CAF from ME4 was nearly 3-fold higher than control (P &lt; 0.05) with improved permeated amount through the skin.	Caffeine	28-31	protocadherin beta 17 pseudogene	Homo sapiens	37-40
25591953-9	2015	In pharmacodynamics studies, CAF-loaded ME4 was superior in terms of increasing apoptotic sunburn cells (P &lt; 0.05) as compared with control.	Caffeine	29-32	protocadherin beta 17 pseudogene	Homo sapiens	40-43
25591953-10	2015	Overall results suggested that the ME4 might be a promising vehicle for the topical delivery of CAF.	Caffeine	96-99	protocadherin beta 17 pseudogene	Homo sapiens	35-38
26367732-0	2015	Caffeine inhibits the growth of glioblastomas through activating the caspase-3 signaling pathway in vitro.	Caffeine	0-8	caspase 3	Homo sapiens	69-78
25951489-6	2015	CD patients using caffeine and patients with arthralgias had a higher risk for RLS.	Caffeine	18-26	RLS1	Homo sapiens	79-82
25939452-1	2015	BACKGROUND AND PURPOSE: Caffeine (a non-selective adenosine receptor antagonist) prevents memory deficits in aging and Alzheimer"s disease, an effect mimicked by adenosine A2 A receptor, but not A1 receptor, antagonists.	Caffeine	24-32	adenosine A2a receptor	Mus musculus	162-185
26367732-7	2015	Flow cytometry detection found that caffeine remarkably arrested the C6 and U87MG cells in G0/G1 phase (C6, U87MG: p&lt;0.01, p&lt;0.05).	Caffeine	36-44	complement C6	Homo sapiens	104-113
26367732-8	2015	Nevertheless, the percentage of cells in S phase obviously decreased in the caffeine-treated group, when comparing to that of the normal control (C6, U87MG: p&lt;0.01, p&lt;0.01).	Caffeine	76-84	complement C6	Homo sapiens	146-155
26367732-9	2015	CCK-8 assay demonstrated that significant decreases in the number of glioblastoma cells were observed in caffeine treatment group, when comparing to that of the normal control (C6, U87MG: p&lt;0.01, p&lt;0.05).	Caffeine	105-113	complement C6	Homo sapiens	177-186
26367732-10	2015	Flow cytometric analysis also found that the application of caffeine induced much higher apoptosis of glioblastoma cells, compared with the normal control (C6, U87MG: p&lt;0.01, p&lt;0.05).	Caffeine	60-68	complement C6	Homo sapiens	156-165
26367732-11	2015	Furthermore, caffeine markedly reduced the expression of Bcl-2 (C6, U87MG: p&lt;0.01, p&lt;0.01), and promoted the expression of Cyt-C (C6, U87MG: p&lt;0.05, p&lt;0.01) and Caspase-3 (C6, U87MG: p&lt;0.01, p&lt;0.01), comparing to the normal control.	Caffeine	13-21	BCL2 apoptosis regulator	Homo sapiens	57-62
26367732-11	2015	Furthermore, caffeine markedly reduced the expression of Bcl-2 (C6, U87MG: p&lt;0.01, p&lt;0.01), and promoted the expression of Cyt-C (C6, U87MG: p&lt;0.05, p&lt;0.01) and Caspase-3 (C6, U87MG: p&lt;0.01, p&lt;0.01), comparing to the normal control.	Caffeine	13-21	complement C6	Homo sapiens	64-73
26367732-11	2015	Furthermore, caffeine markedly reduced the expression of Bcl-2 (C6, U87MG: p&lt;0.01, p&lt;0.01), and promoted the expression of Cyt-C (C6, U87MG: p&lt;0.05, p&lt;0.01) and Caspase-3 (C6, U87MG: p&lt;0.01, p&lt;0.01), comparing to the normal control.	Caffeine	13-21	complement C6	Homo sapiens	136-145
26367732-11	2015	Furthermore, caffeine markedly reduced the expression of Bcl-2 (C6, U87MG: p&lt;0.01, p&lt;0.01), and promoted the expression of Cyt-C (C6, U87MG: p&lt;0.05, p&lt;0.01) and Caspase-3 (C6, U87MG: p&lt;0.01, p&lt;0.01), comparing to the normal control.	Caffeine	13-21	complement C6	Homo sapiens	173-186
26114447-6	2015	Meanwhile, cAMP, SIRT3 or AMPK inhibitors were treated respectively before incubation with caffeine in oleate-treated HepG2 cells.	Caffeine	91-99	sirtuin 3	Homo sapiens	17-22
25959841-5	2015	ACR also decreased the phosphorylation of extracellular-signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) in U-1240 MG cells, while caffeine reversed this suppression of ERK and JNK phosphorylation caused by ACR treatment.	Caffeine	148-156	mitogen-activated protein kinase 1	Homo sapiens	186-189
25959841-5	2015	ACR also decreased the phosphorylation of extracellular-signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) in U-1240 MG cells, while caffeine reversed this suppression of ERK and JNK phosphorylation caused by ACR treatment.	Caffeine	148-156	mitogen-activated protein kinase 8	Homo sapiens	194-197
26114447-6	2015	Meanwhile, cAMP, SIRT3 or AMPK inhibitors were treated respectively before incubation with caffeine in oleate-treated HepG2 cells.	Caffeine	91-99	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	26-30
26114447-8	2015	Caffeine significantly decreased the mass of fat tissues, lipids, ALT and AST levels in the liver of HED-treated mice.	Caffeine	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	66-69
26114447-8	2015	Caffeine significantly decreased the mass of fat tissues, lipids, ALT and AST levels in the liver of HED-treated mice.	Caffeine	0-8	transmembrane protease, serine 11d	Mus musculus	74-77
26114447-9	2015	Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.	Caffeine	0-8	cAMP responsive element binding protein 1	Mus musculus	75-79
26114447-9	2015	Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.	Caffeine	0-8	sirtuin 3	Mus musculus	80-85
26114447-9	2015	Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.	Caffeine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	86-90
26114447-10	2015	Nile red staining demonstrated that suppression of cAMP, SIRT3 or AMPK in oleate-treated HepG2 cells counteracted the effect of caffeine.	Caffeine	128-136	sirtuin 3	Homo sapiens	57-62
26114447-10	2015	Nile red staining demonstrated that suppression of cAMP, SIRT3 or AMPK in oleate-treated HepG2 cells counteracted the effect of caffeine.	Caffeine	128-136	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	66-70
26114447-11	2015	Moreover, knocking down SIRT3 could down-regulate AMPK and ACC phosphorylation by caffeine.	Caffeine	82-90	sirtuin 3	Mus musculus	24-29
26114447-11	2015	Moreover, knocking down SIRT3 could down-regulate AMPK and ACC phosphorylation by caffeine.	Caffeine	82-90	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	50-54
26114447-12	2015	These results demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism via the cAMP/CREB/SIRT3/AMPK/ACC pathway.	Caffeine	31-39	cAMP responsive element binding protein 1	Mus musculus	127-131
26253492-9	2015	The results showed that few genes were changed after caffeine treatment in adipocytes, and of them only phospholipid transfer protein (PLTP) may be ralated to blood glucose.	Caffeine	53-61	phospholipid transfer protein	Mus musculus	135-139
26114447-12	2015	These results demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism via the cAMP/CREB/SIRT3/AMPK/ACC pathway.	Caffeine	31-39	sirtuin 3	Mus musculus	132-137
26114447-12	2015	These results demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism via the cAMP/CREB/SIRT3/AMPK/ACC pathway.	Caffeine	31-39	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	138-142
26114447-13	2015	SIRT3 functioned as a molecular bridge connecting caffeine and lipid metabolism.	Caffeine	50-58	sirtuin 3	Mus musculus	0-5
25641578-4	2015	Caffeine treatment also induces dephosphorylation of Gln3 and its translocation to the nucleus and transcription of NCR-sensitive genes.	Caffeine	0-8	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	53-57
25872745-6	2015	Accordingly, inhibition of ataxia telangiectasia mutated (ATM) by caffeine or siRNA abolished the increase in the p-Chk2 level and restored the delayed CDK1 kinase activity in ChangX cells.	Caffeine	66-74	ATM serine/threonine kinase	Homo sapiens	27-56
25872745-6	2015	Accordingly, inhibition of ataxia telangiectasia mutated (ATM) by caffeine or siRNA abolished the increase in the p-Chk2 level and restored the delayed CDK1 kinase activity in ChangX cells.	Caffeine	66-74	ATM serine/threonine kinase	Homo sapiens	58-61
25872745-6	2015	Accordingly, inhibition of ataxia telangiectasia mutated (ATM) by caffeine or siRNA abolished the increase in the p-Chk2 level and restored the delayed CDK1 kinase activity in ChangX cells.	Caffeine	66-74	checkpoint kinase 2	Homo sapiens	116-120
25872745-6	2015	Accordingly, inhibition of ataxia telangiectasia mutated (ATM) by caffeine or siRNA abolished the increase in the p-Chk2 level and restored the delayed CDK1 kinase activity in ChangX cells.	Caffeine	66-74	cyclin dependent kinase 1	Homo sapiens	152-156
26011522-5	2015	Under optimized quantitative on-line concentration conditions, the limits of detection for theobromine, caffeine, and theophylline were 1.0, 2.0, and 1.0 muM, respectively.	Caffeine	104-112	latexin	Homo sapiens	154-157
26190541-6	2015	Consistent with increased cAMP signaling, D1R-mediated motor stimulation, haloperidol-induced catalepsy and caffeine-evoked hyper-activity are robustly enhanced in Rhes KO females compared to mutant males.	Caffeine	108-116	RASD family, member 2	Mus musculus	164-168
25262754-4	2015	In MR(SMKO) mice, contractions induced by potassium chloride and calcium (Ca(2+)) are decreased in the aorta, whereas contraction is normal in response to phenylephrine and caffeine.	Caffeine	173-181	nuclear receptor subfamily 3, group C, member 2	Mus musculus	3-5
26048820-1	2015	The first step in caffeine metabolism is mediated for over 95% by the CYP1A2 isoform of cytochrome P450.	Caffeine	18-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
26048820-2	2015	Therefore, CYP1A2 activity is most conveniently measured through the determination of caffeine clearance.	Caffeine	86-94	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	11-17
25944789-14	2015	However, caffeine infusion did increase the heart rate prior to CLP and prevented the decline in heart rate after CLP.	Caffeine	9-17	hyaluronan and proteoglycan link protein 1	Mus musculus	64-67
25944789-14	2015	However, caffeine infusion did increase the heart rate prior to CLP and prevented the decline in heart rate after CLP.	Caffeine	9-17	hyaluronan and proteoglycan link protein 1	Mus musculus	114-117
26038236-0	2015	Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	108-114
26038236-2	2015	Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	121-127
26038236-2	2015	Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans.	Caffeine	10-13	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	121-127
25937560-5	2015	Perfusion of cardiomyocytes with a high concentration of caffeine (10 mM) was carried out to verify the function of the cardiac Na(+)/Ca(2+) exchanger (NCX) and the activity of sarco(endo)-plasmic reticulum Ca(2+)-ATPase (SERCA2a).	Caffeine	57-65	solute carrier family 8 member A1	Rattus norvegicus	128-150
25998124-3	2015	RyR1-G4934A, -G4941A, and -G4941V mutant channels exhibited a caffeine-induced Ca(2+) release response in HEK293 cells and bound the RyR-specific ligand [(3)H]ryanodine.	Caffeine	62-70	ryanodine receptor 1	Homo sapiens	0-4
25998124-3	2015	RyR1-G4934A, -G4941A, and -G4941V mutant channels exhibited a caffeine-induced Ca(2+) release response in HEK293 cells and bound the RyR-specific ligand [(3)H]ryanodine.	Caffeine	62-70	ryanodine receptor 1	Homo sapiens	0-3
26100888-2	2015	It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine at the D2R.	Caffeine	58-66	adenosine A2a receptor	Homo sapiens	134-138
25937560-5	2015	Perfusion of cardiomyocytes with a high concentration of caffeine (10 mM) was carried out to verify the function of the cardiac Na(+)/Ca(2+) exchanger (NCX) and the activity of sarco(endo)-plasmic reticulum Ca(2+)-ATPase (SERCA2a).	Caffeine	57-65	solute carrier family 8 member A1	Rattus norvegicus	152-155
26339337-0	2015	Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer"s disease.	Caffeine	29-37	brain-derived neurotrophic factor	Rattus norvegicus	67-100
25897037-2	2015	We used the caffeine breath test to assess the metabolising activity of cytochrome P450 1A2 (CYP1A2) enzyme in underweight children.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-91
25897037-2	2015	We used the caffeine breath test to assess the metabolising activity of cytochrome P450 1A2 (CYP1A2) enzyme in underweight children.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99
25603821-3	2015	The standard approach for CYP1A2 phenotyping is to determine the paraxanthine/caffeine ratio in plasma at a fixed timepoint after intake of a dose of the CYP1A2 substrate caffeine.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	26-32
25603821-3	2015	The standard approach for CYP1A2 phenotyping is to determine the paraxanthine/caffeine ratio in plasma at a fixed timepoint after intake of a dose of the CYP1A2 substrate caffeine.	Caffeine	171-179	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	26-32
25603821-3	2015	The standard approach for CYP1A2 phenotyping is to determine the paraxanthine/caffeine ratio in plasma at a fixed timepoint after intake of a dose of the CYP1A2 substrate caffeine.	Caffeine	171-179	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	154-160
26339337-0	2015	Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer"s disease.	Caffeine	29-37	glial fibrillary acidic protein	Rattus norvegicus	139-170
26339337-2	2015	This study was designed to demonstrate the protective effect of caffeine on gene expression of brain derived neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine kinase-beta (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD.	Caffeine	64-72	brain-derived neurotrophic factor	Rattus norvegicus	95-128
26339337-2	2015	This study was designed to demonstrate the protective effect of caffeine on gene expression of brain derived neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine kinase-beta (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD.	Caffeine	64-72	brain-derived neurotrophic factor	Rattus norvegicus	130-134
26339337-2	2015	This study was designed to demonstrate the protective effect of caffeine on gene expression of brain derived neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine kinase-beta (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD.	Caffeine	64-72	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	199-203
26339337-2	2015	This study was designed to demonstrate the protective effect of caffeine on gene expression of brain derived neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine kinase-beta (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD.	Caffeine	64-72	glial fibrillary acidic protein	Rattus norvegicus	249-253
26339337-5	2015	The results of this study revealed that caffeine has protective effect through improving the histological and immunohistochemical findings induced by AlCl3 as well as BDNF and its receptor gene expression.	Caffeine	40-48	brain-derived neurotrophic factor	Rattus norvegicus	167-171
26121139-8	2015	Increasing RyR2 activity of permeabilized WT myocytes by exposure to caffeine (150 microM) increased the potency of FLEC and RPROP but not of TET.	Caffeine	69-77	ryanodine receptor 2, cardiac	Mus musculus	11-15
25818199-1	2015	We have previously reported that the methylxanthine caffeine increases expression of the splicing factor SRSF2, the levels of which are normally controlled by a negative autoregulatory loop.	Caffeine	52-60	serine and arginine rich splicing factor 2	Homo sapiens	105-110
26056314-5	2015	Except for anxiety, for which results were mixed, CUS-induced behavioral and synaptic alterations were prevented by (i) caffeine (1 g/L in the drinking water, starting 3 wk before and continued throughout CUS); (ii) the selective A2AR antagonist KW6002 (3 mg/kg, p.o.	Caffeine	120-128	adenosine A2a receptor	Mus musculus	230-234
25925253-3	2015	In this study, we tested the hypothesis that blocking the Gi protein-coupled adenosine A1 receptor via the nonselective adenosine receptor antagonist caffeine changes Na(+)/H(+) exchanger isoform 3 (NHE3) localization and phosphorylation, resulting in diuresis and natriuresis.	Caffeine	150-158	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	167-197
25925253-3	2015	In this study, we tested the hypothesis that blocking the Gi protein-coupled adenosine A1 receptor via the nonselective adenosine receptor antagonist caffeine changes Na(+)/H(+) exchanger isoform 3 (NHE3) localization and phosphorylation, resulting in diuresis and natriuresis.	Caffeine	150-158	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	199-203
25818199-4	2015	Instead, caffeine induced changes in the levels of SRSF2 3" UTR splice variants.	Caffeine	9-17	serine and arginine rich splicing factor 2	Homo sapiens	51-56
25818199-6	2015	Furthermore, cell-based assays demonstrated that some of the caffeine-induced variants were intrinsically more efficiently translated than others; the addition of caffeine increased the translational efficiency of most SRSF2 transcripts.	Caffeine	61-69	serine and arginine rich splicing factor 2	Homo sapiens	219-224
25818199-6	2015	Furthermore, cell-based assays demonstrated that some of the caffeine-induced variants were intrinsically more efficiently translated than others; the addition of caffeine increased the translational efficiency of most SRSF2 transcripts.	Caffeine	163-171	serine and arginine rich splicing factor 2	Homo sapiens	219-224
25818199-7	2015	MicroRNA array analyses revealed a significant caffeine-mediated decrease in the expression of two SRSF2-targeting miRs, both of which were shown to repress translation of specific SRSF2 splice variants.	Caffeine	47-55	serine and arginine rich splicing factor 2	Homo sapiens	99-104
25818199-7	2015	MicroRNA array analyses revealed a significant caffeine-mediated decrease in the expression of two SRSF2-targeting miRs, both of which were shown to repress translation of specific SRSF2 splice variants.	Caffeine	47-55	serine and arginine rich splicing factor 2	Homo sapiens	181-186
25818199-8	2015	These data support a complex model whereby caffeine down-regulates SRSF2-targeting microRNAs, leading to an increase in SRSF2 translation, which in turn induces SRSF2 splicing.	Caffeine	43-51	serine and arginine rich splicing factor 2	Homo sapiens	67-72
25818199-8	2015	These data support a complex model whereby caffeine down-regulates SRSF2-targeting microRNAs, leading to an increase in SRSF2 translation, which in turn induces SRSF2 splicing.	Caffeine	43-51	serine and arginine rich splicing factor 2	Homo sapiens	120-125
25818199-8	2015	These data support a complex model whereby caffeine down-regulates SRSF2-targeting microRNAs, leading to an increase in SRSF2 translation, which in turn induces SRSF2 splicing.	Caffeine	43-51	serine and arginine rich splicing factor 2	Homo sapiens	120-125
25818199-9	2015	SRSF2 splice variants are then stabilized by caffeine-mediated NMD inhibition, breaking the normal negative feedback loop and allowing the aberrant increase in SRSF2 protein levels.	Caffeine	45-53	serine and arginine rich splicing factor 2	Homo sapiens	0-5
25818199-9	2015	SRSF2 splice variants are then stabilized by caffeine-mediated NMD inhibition, breaking the normal negative feedback loop and allowing the aberrant increase in SRSF2 protein levels.	Caffeine	45-53	serine and arginine rich splicing factor 2	Homo sapiens	160-165
26056854-9	2015	RyR (ryanodine receptor) activation with caffeine resulted in a single contraction with a greater Ca(2+) transient in lymphatics from AAI than those from controls.	Caffeine	41-49	ryanodine receptor 2	Rattus norvegicus	0-3
25864940-7	2015	PNKD episodes are often precipitated by caffeine, ethanol, or sleep deprivation, and lifestyle modifications are often helpful.	Caffeine	40-48	PNKD metallo-beta-lactamase domain containing	Homo sapiens	0-4
25700100-6	2015	Caffeine clearance was 0.95+-0.14 mL min(-1) kg(-1) while the elimination half-life of caffeine was 17.63+-8.06 h. Paraxanthine and theophylline levels were significantly elevated at 15 h with no significant change in theobromine.	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	37-43
26056854-9	2015	RyR (ryanodine receptor) activation with caffeine resulted in a single contraction with a greater Ca(2+) transient in lymphatics from AAI than those from controls.	Caffeine	41-49	ryanodine receptor 2	Rattus norvegicus	5-23
25211364-9	2015	RESULTS: Compared to placebo, caffeine improved MVC (6.3%, P = 0.014) and %ACT (5.5%, P = 0.013) in the knee extensors, but not the elbow flexors, and reduced muscle pain (P &lt; 0.05) and RPE (P &lt; 0.05) during both submaximal cycling modalities.	Caffeine	30-38	ribulose-5-phosphate-3-epimerase	Homo sapiens	189-192
25211364-10	2015	Caffeine ingestion improved time-trial performance during leg cycling (4.9% +- 6.5%, P = 0.03), but not arm crank cycling (2.1% +- 8.2%, P = 0.28), but the effect on pain and RPE was eliminated.	Caffeine	0-8	ribulose-5-phosphate-3-epimerase	Homo sapiens	175-178
25868845-0	2015	Increased DNA methylation of scavenger receptor class B type I contributes to inhibitory effects of prenatal caffeine ingestion on cholesterol uptake and steroidogenesis in fetal adrenals.	Caffeine	109-117	scavenger receptor class B, member 1	Rattus norvegicus	29-62
25895691-7	2015	Pretreatment with the H1R antagonist pyrilamine abolished caffeine-induced stimulation on locomotor activity in fasted mice.	Caffeine	58-66	histamine receptor H1	Mus musculus	22-25
25895691-11	2015	These results indicate that caffeine had greater wakefulness-promoting effects in fasted mice through the mediation of H1R.	Caffeine	28-36	histamine receptor H1	Mus musculus	119-122
25868845-8	2015	The following conjoint analysis of DNA methylation array with these differentially expressed genes suggested that scavenger receptor class B type I (SR-BI) may play an important role in caffeine-induced cholesterol supply deficiency.	Caffeine	186-194	scavenger receptor class B, member 1	Rattus norvegicus	114-147
25868845-8	2015	The following conjoint analysis of DNA methylation array with these differentially expressed genes suggested that scavenger receptor class B type I (SR-BI) may play an important role in caffeine-induced cholesterol supply deficiency.	Caffeine	186-194	scavenger receptor class B, member 1	Rattus norvegicus	149-154
25868845-9	2015	Moreover, real-time RT-PCR and immunohistochemical detection certified the inhibitory effects of caffeine on both mRNA expression and protein expression of SR-BI in the fetal adrenal.	Caffeine	97-105	scavenger receptor class B, member 1	Rattus norvegicus	156-161
25868845-11	2015	In conclusion, prenatal caffeine ingestion can induce DNA hypermethylation of the SR-BI promoter in the rat fetal adrenal.	Caffeine	24-32	scavenger receptor class B, member 1	Rattus norvegicus	82-87
25992797-2	2015	Here we present a comparative molecular dynamics (MD) study of the human adenosine receptor type 2A (hA(2A)R) in complex with caffeine--a system of high neuro-pharmacological relevance--within different membrane types.	Caffeine	126-134	adenosine A2a receptor	Homo sapiens	101-108
26029007-0	2015	Erratum to: The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-37
25715702-0	2015	Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.	Caffeine	0-8	solute carrier family 2 member 1	Homo sapiens	54-59
25715702-9	2015	Like ATP, caffeine renders the GLUT1 carboxy-terminus less accessible to peptide-directed antibodies, but cytochalasin B and d-glucose do not.	Caffeine	10-18	solute carrier family 2 member 1	Homo sapiens	31-36
25715702-10	2015	These results suggest that the caffeine-binding site bridges two nonoverlapping GLUT1 endofacial sites-the regulatory, nucleotide-binding site and the cytochalasin B-binding site.	Caffeine	31-39	solute carrier family 2 member 1	Homo sapiens	80-85
25715702-11	2015	Caffeine binding to GLUT1 mimics the action of ATP but not cytochalasin B on sugar transport.	Caffeine	0-8	solute carrier family 2 member 1	Homo sapiens	20-25
25810258-1	2015	Focus on "Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site".	Caffeine	10-18	solute carrier family 2 member 1	Homo sapiens	64-69
25715702-2	2015	A recent study proposes that caffeine uncompetitive inhibition of GLUT1 results from interactions at an exofacial GLUT1 site.	Caffeine	29-37	solute carrier family 2 member 1	Homo sapiens	66-71
25715702-2	2015	A recent study proposes that caffeine uncompetitive inhibition of GLUT1 results from interactions at an exofacial GLUT1 site.	Caffeine	29-37	solute carrier family 2 member 1	Homo sapiens	114-119
25715702-3	2015	Intracellular ATP is also an uncompetitive GLUT1 inhibitor and shares structural similarities with caffeine, suggesting that caffeine acts at the previously characterized endofacial GLUT1 nucleotide-binding site.	Caffeine	99-107	solute carrier family 2 member 1	Homo sapiens	182-187
25715702-3	2015	Intracellular ATP is also an uncompetitive GLUT1 inhibitor and shares structural similarities with caffeine, suggesting that caffeine acts at the previously characterized endofacial GLUT1 nucleotide-binding site.	Caffeine	125-133	solute carrier family 2 member 1	Homo sapiens	182-187
25715702-4	2015	We tested this by confirming that caffeine uncompetitively inhibits GLUT1-mediated 3-O-methylglucose uptake in human erythrocytes [Vmax and Km for transport are reduced fourfold; Ki(app) = 3.5 mM caffeine].	Caffeine	34-42	solute carrier family 2 member 1	Homo sapiens	68-73
25715702-7	2015	Caffeine and ATP displace the fluorescent ATP derivative, trinitrophenyl-ATP, from the GLUT1 nucleotide-binding site, but d-glucose and the transport inhibitor cytochalasin B do not.	Caffeine	0-8	solute carrier family 2 member 1	Homo sapiens	87-92
25715702-8	2015	Caffeine, but not ATP, inhibits cytochalasin B binding to GLUT1.	Caffeine	0-8	solute carrier family 2 member 1	Homo sapiens	58-63
25812484-5	2015	Furthermore, ATM/ATR inhibitor caffeine, p53- or ATM/ATR-specific siRNA significantly attenuated 8-ADEQ-induced G2/M arrest.	Caffeine	31-39	ATM serine/threonine kinase	Homo sapiens	13-16
26270218-3	2015	Caffeine was detected in all samples, with concentrations ranging from 0.15 ng mL-1 to 16.72 ng mL-1.	Caffeine	0-8	L1 cell adhesion molecule	Mus musculus	79-83
26270218-3	2015	Caffeine was detected in all samples, with concentrations ranging from 0.15 ng mL-1 to 16.72 ng mL-1.	Caffeine	0-8	L1 cell adhesion molecule	Mus musculus	96-100
26058150-2	2015	Five days after treatment with 500 muM caffeine, theophylline and paraxanthine, division of isolated protoplasts was significantly inhibited.	Caffeine	39-47	latexin	Homo sapiens	35-38
26058150-3	2015	Thirteen days treatment with &gt; 250 muM caffeine had a marked inhibitory effect on the colony formation of cells derived from the protoplasts.	Caffeine	42-50	latexin	Homo sapiens	38-41
25884315-1	2015	This study aimed to investigate whether isolated or combined carbohydrate (CHO) and caffeine (CAF) supplementation have beneficial effects on performance during soccer-related tests performed after a previous training session.	Caffeine	84-92	lysine acetyltransferase 2B	Homo sapiens	94-97
25557829-9	2015	Caffeine down-regulated endothelial nitric oxide synthase, vascular endothelial growth factor (VEGF), phospho-VEGFR2, and phospho-Akt mesenteric protein expression.	Caffeine	0-8	vascular endothelial growth factor A	Rattus norvegicus	59-93
25557829-9	2015	Caffeine down-regulated endothelial nitric oxide synthase, vascular endothelial growth factor (VEGF), phospho-VEGFR2, and phospho-Akt mesenteric protein expression.	Caffeine	0-8	vascular endothelial growth factor A	Rattus norvegicus	95-99
25557829-9	2015	Caffeine down-regulated endothelial nitric oxide synthase, vascular endothelial growth factor (VEGF), phospho-VEGFR2, and phospho-Akt mesenteric protein expression.	Caffeine	0-8	kinase insert domain receptor	Rattus norvegicus	110-116
25557829-9	2015	Caffeine down-regulated endothelial nitric oxide synthase, vascular endothelial growth factor (VEGF), phospho-VEGFR2, and phospho-Akt mesenteric protein expression.	Caffeine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	75-80
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	aryl hydrocarbon receptor	Homo sapiens	82-85
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	cytochrome p450 oxidoreductase	Homo sapiens	87-90
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	95-101
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	brain derived neurotrophic factor	Homo sapiens	125-129
25288136-6	2015	Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.	Caffeine	145-153	solute carrier family 6 member 4	Homo sapiens	134-140
25288136-9	2015	SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P&lt;5 x 10(-8)).Our genetic findings among European and African-American adults reinforce the role of caffeine in mediating habitual coffee consumption and may point to molecular mechanisms underlying inter-individual variability in pharmacological and health effects of coffee.	Caffeine	394-402	glucokinase regulator	Homo sapiens	17-21
25812484-5	2015	Furthermore, ATM/ATR inhibitor caffeine, p53- or ATM/ATR-specific siRNA significantly attenuated 8-ADEQ-induced G2/M arrest.	Caffeine	31-39	ATR serine/threonine kinase	Homo sapiens	17-20
25871974-0	2015	Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain.	Caffeine	0-8	dopamine receptor D2	Homo sapiens	28-51
25691730-8	2015	Caffeine significantly reduced ER and cyclin D1 abundance in ER(+) cells.	Caffeine	0-8	cyclin D1	Homo sapiens	38-47
25691730-9	2015	Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER(+) and ER(-) cells.	Caffeine	0-8	insulin like growth factor 1 receptor	Homo sapiens	26-63
25691730-9	2015	Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER(+) and ER(-) cells.	Caffeine	0-8	insulin like growth factor 1 receptor	Homo sapiens	65-70
25661425-0	2015	Disclosing caffeine action on insulin sensitivity: effects on rat skeletal muscle.	Caffeine	11-19	insulin	Homo sapiens	30-37
25661425-1	2015	Caffeine, a non-selective adenosine antagonist, has distinct effects on insulin sensitivity when applied acutely or chronically.	Caffeine	0-8	insulin	Homo sapiens	72-79
25661425-2	2015	Herein, we investigated the involvement of adenosine receptors on insulin resistance induced by single-dose caffeine administration.	Caffeine	108-116	insulin	Homo sapiens	66-73
25661425-8	2015	Acute caffeine decreased insulin sensitivity in a concentration dependent manner (Emax=55.54+-5.37%, IC50=11.61nM), an effect that was mediated by A1 and A2B adenosine receptors.	Caffeine	6-14	insulin	Homo sapiens	25-32
25661425-9	2015	Additionally, acute caffeine administration significantly decreased Glut4, but not AMPK expression, in skeletal muscle.	Caffeine	20-28	solute carrier family 2 member 4	Rattus norvegicus	68-73
25661425-12	2015	Our results suggest that insulin resistance induced by acute caffeine administration is mediated by A1 and A2B adenosine receptors.	Caffeine	61-69	insulin	Homo sapiens	25-32
25661425-13	2015	Both Glut4 and NO seem to be downstream effectors involved in insulin resistance induced by acute caffeine.	Caffeine	98-106	solute carrier family 2 member 4	Rattus norvegicus	5-10
25661425-13	2015	Both Glut4 and NO seem to be downstream effectors involved in insulin resistance induced by acute caffeine.	Caffeine	98-106	insulin	Homo sapiens	62-69
25701503-11	2015	Results of immunohistochemistry, real-time PCR and western blot indicated that caffeine could reduce fibrosis and inhibit cAMP/PKA/CREB signal pathway in HSC.	Caffeine	79-87	cAMP responsive element binding protein 1	Rattus norvegicus	131-135
25442519-4	2015	The obtained detection limits for caffeine following 120 s of accumulation time were equal to 1.7 x 10(-8) mol L(-1) (for peak 1) and 2.2 x 10(-7) mol L(-1) (for peak 2).	Caffeine	34-42	pseudopodium enriched atypical kinase 1	Homo sapiens	122-128
25442519-4	2015	The obtained detection limits for caffeine following 120 s of accumulation time were equal to 1.7 x 10(-8) mol L(-1) (for peak 1) and 2.2 x 10(-7) mol L(-1) (for peak 2).	Caffeine	34-42	PEAK1 related, kinase-activating pseudokinase 1	Homo sapiens	162-168
25701503-0	2015	Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells.	Caffeine	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	83-87
25701503-13	2015	The mechanism may be interpreted that caffeine inhibits the cAMP/PKA/CREB signal pathway through adenosine A2A receptors in HSC.	Caffeine	38-46	cAMP responsive element binding protein 1	Rattus norvegicus	69-73
25481367-3	2015	Consumption of 5 mg/kg caffeine had an impact on participants" SBP, standard deviation of normal heartbeat intervals, HR (decrease), and subjective experience 40 minutes later even after controlling for respective baseline values, stimulus and response expectancies, and habitual caffeine consumption.	Caffeine	23-31	selenium binding protein 1	Homo sapiens	63-66
25820086-0	2015	Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.	Caffeine	111-119	CART prepropeptide	Mus musculus	12-57
25820086-0	2015	Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.	Caffeine	111-119	CART prepropeptide	Mus musculus	59-63
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	32-40	CART prepropeptide	Mus musculus	199-203
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	240-248	CART prepropeptide	Mus musculus	152-197
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	240-248	CART prepropeptide	Mus musculus	199-203
25820086-3	2015	Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum.	Caffeine	50-58	CART prepropeptide	Mus musculus	84-88
25820086-5	2015	To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice.	Caffeine	140-148	CART prepropeptide	Mus musculus	85-89
25820086-5	2015	To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice.	Caffeine	140-148	CART prepropeptide	Mus musculus	108-112
25820086-6	2015	We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas.	Caffeine	29-37	CART prepropeptide	Mus musculus	74-78
25820086-6	2015	We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas.	Caffeine	29-37	carcinoembryonic antigen gene family	Mus musculus	232-235
25820086-7	2015	In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg.	Caffeine	13-21	CART prepropeptide	Mus musculus	112-116
25820086-7	2015	In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg.	Caffeine	13-21	CART prepropeptide	Mus musculus	180-184
25820086-8	2015	This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration.	Caffeine	100-108	CART prepropeptide	Mus musculus	26-30
25820086-8	2015	This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration.	Caffeine	100-108	carcinoembryonic antigen gene family	Mus musculus	51-54
25518926-5	2015	Expression of the DRL1 gene in a yeast KTI12-deficient yeast mutant suppressed the growth retardation phenotype, but did not rescue the caffeine sensitivity, indicating that the role of Arabidopsis Elongator-associated protein is partially conserved with yeast KTI12, but may have changed between yeast and plants in response to caffeine during the course of evolution.	Caffeine	329-337	KTI12-like, chromatin associated protein	Arabidopsis thaliana	18-22
24752775-8	2015	Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1).	Caffeine	39-47	leptin	Homo sapiens	89-95
24752775-8	2015	Similar associations were observed for caffeine consumption (P for trend = 0.02 for both leptin and PAI-1).	Caffeine	39-47	serpin family E member 1	Homo sapiens	100-105
24752775-12	2015	CONCLUSIONS: Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.	Caffeine	46-54	leptin	Homo sapiens	115-121
24752775-12	2015	CONCLUSIONS: Higher consumption of coffee and caffeine but not green tea was associated with lower serum levels of leptin and PAI-1 in Japanese adults.	Caffeine	46-54	serpin family E member 1	Homo sapiens	126-131
24499289-6	2015	Perfusion of cardiomyocytes with a high concentration of caffeine (10 mM) was carried out to verify the function of the cardiac Na(+)/Ca(2+) exchanger (NCX) and the activity of sarco(endo)-plasmic reticulum Ca(2+)-ATPase (SERCA2a).	Caffeine	57-65	solute carrier family 8 member A1	Rattus norvegicus	128-150
24499289-6	2015	Perfusion of cardiomyocytes with a high concentration of caffeine (10 mM) was carried out to verify the function of the cardiac Na(+)/Ca(2+) exchanger (NCX) and the activity of sarco(endo)-plasmic reticulum Ca(2+)-ATPase (SERCA2a).	Caffeine	57-65	solute carrier family 8 member A1	Rattus norvegicus	152-155
25328052-10	2015	Caffeine consumption during adolescence also increased the expression of the dopamine D2 receptor, dopamine transporter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.	Caffeine	0-8	adenosine A1 receptor	Rattus norvegicus	125-146
25328052-10	2015	Caffeine consumption during adolescence also increased the expression of the dopamine D2 receptor, dopamine transporter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.	Caffeine	0-8	adenosine A2a receptor	Rattus norvegicus	161-183
25328052-11	2015	Consumption of caffeine during adulthood increased adenosine A1 receptor expression in the NAc, but no other protein expression changes were observed.	Caffeine	15-23	adenosine A1 receptor	Rattus norvegicus	51-72
25726373-7	2015	Caffeine increased (p&lt;0.05) LHbeta gene expression only in explants from LPS-treated animals.	Caffeine	0-8	luteinizing hormone subunit beta	Homo sapiens	31-37
25144514-0	2015	Tea component, epigallocatechin gallate, potentiates anticataleptic and locomotor-sensitizing effects of caffeine in mice.	Caffeine	105-113	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
25649420-6	2015	RESULTS: The osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules.	Caffeine	80-88	bone gamma-carboxyglutamate protein	Rattus norvegicus	140-151
25649420-6	2015	RESULTS: The osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules.	Caffeine	80-88	secreted phosphoprotein 1	Rattus norvegicus	153-164
25649420-6	2015	RESULTS: The osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules.	Caffeine	80-88	cysteine-rich secretory protein 3	Rattus norvegicus	166-178
25649420-6	2015	RESULTS: The osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules.	Caffeine	80-88	RUNX family transcription factor 2	Rattus norvegicus	180-186
25649420-7	2015	CONCLUSIONS: Neonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.	Caffeine	54-62	bone gamma-carboxyglutamate protein	Rattus norvegicus	178-189
25649420-7	2015	CONCLUSIONS: Neonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.	Caffeine	54-62	secreted phosphoprotein 1	Rattus norvegicus	191-202
25649420-7	2015	CONCLUSIONS: Neonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.	Caffeine	54-62	cysteine-rich secretory protein 3	Rattus norvegicus	204-216
25649420-7	2015	CONCLUSIONS: Neonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.	Caffeine	54-62	RUNX family transcription factor 2	Rattus norvegicus	218-224
25144514-2	2015	Caffeine, the psychoactive principle of tea, pharmacologically interacts with several drugs and bioactive molecules.	Caffeine	0-8	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	40-43
25760542-3	2015	In addition, cynomolgus CYP2C9 also metabolizes caffeine, resulting in the formation of the metabolite that is not generated efficiently in humans.	Caffeine	48-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
25686090-0	2015	Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.	Caffeine	58-66	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	34-39
25052067-6	2015	When caffeine was administered after the AAC, both subjective sleepiness and the slowing in RTs were significantly milder than in the AAC-only condition.	Caffeine	5-13	glycine-N-acyltransferase	Homo sapiens	41-44
25052067-6	2015	When caffeine was administered after the AAC, both subjective sleepiness and the slowing in RTs were significantly milder than in the AAC-only condition.	Caffeine	5-13	glycine-N-acyltransferase	Homo sapiens	134-137
25451122-0	2015	Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring.	Caffeine	9-17	acetylcholinesterase	Rattus norvegicus	73-93
25451122-9	2015	We found decreased AChE activity in the caffeine group compared to the other groups, with no alteration in AChE transcriptional regulation.	Caffeine	40-48	acetylcholinesterase	Rattus norvegicus	19-23
25474697-10	2015	Moreover, the antagonism of dopamine D1 receptor and not D2 receptor reversed the effect of caffeine on the social avoidance and depressive-like behavior.	Caffeine	92-100	dopamine receptor D1	Mus musculus	28-48
25471153-4	2015	MNN2-repressed sur1Delta csh1Delta cells exhibited high sensitivity to zymolyase treatment, and caffeine and sodium dodecyl sulfate (SDS) strongly inhibited the growth of sur1Delta csh1Delta cells, suggesting impairment of cell integrity due to the loss of MIPC synthesis.	Caffeine	96-104	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1	Saccharomyces cerevisiae S288C	171-175
25592006-0	2015	Effect of post-exercise caffeine and green coffee bean extract consumption on blood glucose and insulin concentrations.	Caffeine	24-32	insulin	Homo sapiens	96-103
25592006-1	2015	OBJECTIVE: The aim of this study was to investigate the effects of ingesting caffeine and green coffee bean extract on blood glucose and insulin concentrations during a post-exercise oral glucose tolerance test.	Caffeine	77-85	insulin	Homo sapiens	137-144
25409936-7	2015	In addition, hepatic expressions of genes related to lipogenesis, such as sterol regulatory element-binding protein-1c or fatty acid synthase, were significantly lower in the mice fed G-hesperidin + caffeine compared with that in the control mice.	Caffeine	199-207	fatty acid synthase	Mus musculus	122-141
25666502-0	2015	Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway.	Caffeine	21-29	AKT serine/threonine kinase 1	Homo sapiens	91-94
25666502-13	2015	All in all, this observation indicated that caffeine may suppress the progression of HCC through Akt signaling pathway.	Caffeine	44-52	AKT serine/threonine kinase 1	Homo sapiens	97-100
25921178-1	2015	The aim of the present study was to evaluate the relative contribution of CYP1A2 isoforms (-3860 G/A, -2467T/delT and -163C/A) in control subjects and breast cancer patients to the metabolism of caffeine in human liver.	Caffeine	195-203	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	74-80
25921178-2	2015	Restriction fragment length polymorphism analysis of PCR-amplified Fragments (PCR-RFLP) was used for the genotyping of CYP1A2 SNPs and HPLC allowed the phenotyping through the measurement of CYP1A2 activity using the 17X + 13X + 37X/137X urinary metabolite ratio (CMR) and plasma caffeine half life (T1/2).	Caffeine	280-288	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
25686090-0	2015	Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.	Caffeine	58-66	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	44-49
25686090-1	2015	SNQ2 was identified as a caffeine-resistance gene by screening a genomic library of Saccharomyces cerevisiae in a multicopy vector YEp24.	Caffeine	25-33	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	0-4
25686090-3	2015	Multicopy of PDR5 also conferred resistance to caffeine, while its resistance was smaller than that of SNQ2.	Caffeine	47-55	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	13-17
25686090-7	2015	R6G was exported by both transporters, and their efflux activities were inhibited by caffeine with half-maximal inhibitory concentrations of 5.3 +- 1.9 (YEp24-SNQ2) and 17.2 +- 9.6 mM (YEp24-PDR5).	Caffeine	85-93	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	159-163
25686090-7	2015	R6G was exported by both transporters, and their efflux activities were inhibited by caffeine with half-maximal inhibitory concentrations of 5.3 +- 1.9 (YEp24-SNQ2) and 17.2 +- 9.6 mM (YEp24-PDR5).	Caffeine	85-93	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	191-195
25686090-8	2015	These results demonstrate that Snq2p is a more functional transporter of caffeine than Pdr5p in yeast cells.	Caffeine	73-81	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	31-36
25544641-7	2015	Interestingly, caffeine, a known adenosine receptor antagonist, has been recently considered as a lead compound for the design and discovery of A2A antagonists and MAO-B inhibitors.	Caffeine	15-23	monoamine oxidase B	Homo sapiens	164-169
26764541-8	2015	Up-regulation of adenosine A1 receptor expression might contribute to the favorable effects of chronic caffeine consumption.	Caffeine	103-111	adenosine A1 receptor	Mus musculus	17-38
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Caffeine	43-51	leptin	Rattus norvegicus	133-139
25044726-5	2015	RESULTS: Women with T1DM had lower oxytocin levels than controls adjusting for caffeine and alcohol use (p = 0.03).	Caffeine	79-87	oxytocin/neurophysin I prepropeptide	Homo sapiens	35-43
25044726-8	2015	In T1DM only, oxytocin was positively associated with caffeine intake (p = 0.01) and negatively associated with alcohol use (p = 0.01).	Caffeine	54-62	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Caffeine	43-51	interleukin 6	Rattus norvegicus	236-240
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Caffeine	43-51	tumor necrosis factor	Rattus norvegicus	245-254
26402756-6	2015	In addition, caffeine as well as siRNA knockdown of A3Rs blocked the ability of LDL cholesterol to increase Abeta levels.	Caffeine	13-21	amyloid beta precursor protein	Homo sapiens	108-113
25737971-0	2015	Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes.	Caffeine	16-24	adiponectin, C1Q and collagen domain containing	Homo sapiens	30-41
26401784-0	2015	Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-beta Levels in Patients with Alzheimer"s Disease?	Caffeine	5-13	amyloid beta precursor protein	Homo sapiens	53-65
26401784-1	2015	Caffeine may be protective against Alzheimer"s disease (AD) by modulating amyloid-beta (Abeta) metabolic pathways.	Caffeine	0-8	amyloid beta precursor protein	Homo sapiens	74-86
26401784-1	2015	Caffeine may be protective against Alzheimer"s disease (AD) by modulating amyloid-beta (Abeta) metabolic pathways.	Caffeine	0-8	amyloid beta precursor protein	Homo sapiens	88-93
26401784-2	2015	The present work aimed to study a possible association of caffeine consumption with the cerebrospinal fluid (CSF) biomarkers, particularly Abeta.	Caffeine	58-66	amyloid beta precursor protein	Homo sapiens	139-144
24114907-2	2015	Caffeine breath test (CBT) has been used to determine the activity of cytochrome P450 1A2 (CYP1A2) enzymes in children.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-89
24114907-2	2015	Caffeine breath test (CBT) has been used to determine the activity of cytochrome P450 1A2 (CYP1A2) enzymes in children.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-97
26664829-9	2015	Plasma HSP70 differed by caffeine and protein.	Caffeine	25-33	heat shock protein family A (Hsp70) member 4	Homo sapiens	7-12
26664829-14	2015	Differences in baseline CK and IL-6 plasma protein concentrations are associated with genetics, sex, ethnicity, and the use of oral contraceptives, caffeine, and protein supplements in this young and athletic population.	Caffeine	148-156	interleukin 6	Homo sapiens	31-35
25313402-0	2015	The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.	Caffeine	39-47	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	24-29
25313402-0	2015	The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.	Caffeine	39-47	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	100-104
25313402-0	2015	The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.	Caffeine	39-47	phosphoprotein phosphatase 2A catalytic subunit PPH21	Saccharomyces cerevisiae S288C	142-147
25313402-0	2015	The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.	Caffeine	39-47	phosphoprotein phosphatase 2A catalytic subunit PPH22	Saccharomyces cerevisiae S288C	152-157
25313402-1	2015	The Saccharomyces cerevisiae Siw14, a tyrosine phosphatase involved in the response to caffeine, participates in regulation of the phosphorylation and intracellular localization of Gln3, a GATA transcriptional activator of nitrogen catabolite repression-sensitive genes.	Caffeine	87-95	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	29-34
25313402-1	2015	The Saccharomyces cerevisiae Siw14, a tyrosine phosphatase involved in the response to caffeine, participates in regulation of the phosphorylation and intracellular localization of Gln3, a GATA transcriptional activator of nitrogen catabolite repression-sensitive genes.	Caffeine	87-95	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	181-185
25313402-2	2015	In Deltasiw14 cells, the phosphorylation level of Gln3 is decreased and the nuclear localization of Gln3 is stimulated by caffeine.	Caffeine	122-130	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	100-104
25313402-4	2015	In this study, we show that the increased nuclear localization of Gln3 in response to caffeine caused by disruption of the SIW14 gene is dependent on the Sit4 and PP2A phosphatases.	Caffeine	86-94	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	66-70
25313402-4	2015	In this study, we show that the increased nuclear localization of Gln3 in response to caffeine caused by disruption of the SIW14 gene is dependent on the Sit4 and PP2A phosphatases.	Caffeine	86-94	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	123-128
25313402-4	2015	In this study, we show that the increased nuclear localization of Gln3 in response to caffeine caused by disruption of the SIW14 gene is dependent on the Sit4 and PP2A phosphatases.	Caffeine	86-94	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	154-158
25737971-10	2015	CONCLUSION: The long term use of caffeine is more efficient on blood sugar and adiponectin levels, which needed in the prevention of complications in diabetic subjects.	Caffeine	33-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90
26538827-0	2015	Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE2 Synthesis of HBx(+) Hepatocytes.	Caffeine	87-95	prostaglandin E synthase	Mus musculus	18-25
26670362-0	2015	Relationship between Caffeine and Levels of DNA Repair and Oxidative Stress in Women with and without a BRCA1 Mutation.	Caffeine	21-29	BRCA1 DNA repair associated	Homo sapiens	104-109
25827059-4	2015	Total sprint times were faster after sodium phosphate and caffeine supplementation compared with placebo (Set 1: P = 0.003; Set 2: d = -0.51; Set 3: P &lt; 0.001; overall: P = 0.020), caffeine (Set 3: P = 0.004; overall: P = 0.033) and sodium phosphate (Set 3: d = -0.67).	Caffeine	58-66	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	106-111
26538827-0	2015	Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE2 Synthesis of HBx(+) Hepatocytes.	Caffeine	87-95	early growth response 1	Homo sapiens	41-45
26538827-6	2015	Moreover, the expression of EGR1 and PPARgamma changed more significantly in HBx(+) hepatocytes cultured for 12 to 24 hours in the presence of 5 mM caffeine.	Caffeine	148-156	early growth response 1	Homo sapiens	28-32
26538827-6	2015	Moreover, the expression of EGR1 and PPARgamma changed more significantly in HBx(+) hepatocytes cultured for 12 to 24 hours in the presence of 5 mM caffeine.	Caffeine	148-156	peroxisome proliferator activated receptor gamma	Homo sapiens	37-46
26538827-7	2015	This limited success may be attributed to caffeine releasing the binding of HBx and PPARgamma and furthermore affecting the mPGES-1 expression by EGR1 in HBx(+) hepatocytes.	Caffeine	42-50	peroxisome proliferator activated receptor gamma	Homo sapiens	84-93
26538827-7	2015	This limited success may be attributed to caffeine releasing the binding of HBx and PPARgamma and furthermore affecting the mPGES-1 expression by EGR1 in HBx(+) hepatocytes.	Caffeine	42-50	prostaglandin E synthase	Mus musculus	124-131
26538827-7	2015	This limited success may be attributed to caffeine releasing the binding of HBx and PPARgamma and furthermore affecting the mPGES-1 expression by EGR1 in HBx(+) hepatocytes.	Caffeine	42-50	early growth response 1	Homo sapiens	146-150
26538827-8	2015	The results indicate that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARgamma-EGR1-mPGES-1 pathway, thereby providing a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.	Caffeine	26-34	peroxisome proliferator activated receptor gamma	Homo sapiens	126-135
26538827-8	2015	The results indicate that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARgamma-EGR1-mPGES-1 pathway, thereby providing a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.	Caffeine	26-34	early growth response 1	Homo sapiens	136-140
26538827-8	2015	The results indicate that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARgamma-EGR1-mPGES-1 pathway, thereby providing a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.	Caffeine	26-34	prostaglandin E synthase	Mus musculus	141-148
25565776-14	2015	Coff or Caff, plus Mel reduced oxidative stress in N2a/APP cells via the Nrf2 pathway.	Caffeine	8-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
25565776-16	2015	Coff or Caff, plus Mel downregulated Wnt3alpha expression but upregulated beta-catenin.	Caffeine	8-12	wingless-type MMTV integration site family, member 3A	Mus musculus	37-46
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Caffeine	8-12	glycogen synthase kinase 3 beta	Mus musculus	33-41
25565776-16	2015	Coff or Caff, plus Mel downregulated Wnt3alpha expression but upregulated beta-catenin.	Caffeine	8-12	catenin (cadherin associated protein), beta 1	Mus musculus	74-86
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Caffeine	8-12	thymoma viral proto-oncogene 1	Mus musculus	43-46
25565776-19	2015	Taken together, combination of Caff or Coff, before treatment with Mel elicits an additive antiamyloidogenic effects in N2a/APP cells, probably through inhibition of Abeta oligomerization and modulation of the Akt/GSK3beta/Tau signaling pathway.	Caffeine	31-35	thymoma viral proto-oncogene 1	Mus musculus	210-213
25565776-19	2015	Taken together, combination of Caff or Coff, before treatment with Mel elicits an additive antiamyloidogenic effects in N2a/APP cells, probably through inhibition of Abeta oligomerization and modulation of the Akt/GSK3beta/Tau signaling pathway.	Caffeine	31-35	glycogen synthase kinase 3 beta	Mus musculus	214-222
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Caffeine	8-12	polymerase (DNA directed), gamma 2, accessory subunit	Mus musculus	53-56
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Caffeine	8-12	extracellular matrix protein 1	Mus musculus	100-103
25565776-15	2015	Coff or Caff, plus Mel inhibited GSK3beta, Akt, PI3K p55, and Tau phosphorylation but enhanced PI3K p85 and Erk1/2 phosphorylation in N2a/APP cells.	Caffeine	8-12	mitogen-activated protein kinase 3	Mus musculus	108-114
25263335-8	2014	Treatment with the RyR agonist caffeine (1 mmol/L) significantly increased Ca(2+) release in VSMCs exposed to hypoxia for 10 min or 3 h, which was partially antagonized by transfection with RyR2 siRNA.	Caffeine	31-39	ryanodine receptor 2	Rattus norvegicus	19-22
25081642-2	2014	The binding of natural products to alpha-synuclein was evaluated by nanopore analysis and caffeine, curcumin, and nicotine all caused large conformational changes which may be related to their known neuroprotective effect in Parkinson"s disease.	Caffeine	90-98	synuclein alpha	Homo sapiens	35-50
25081642-6	2014	Caffeine and nicotine can bind to alpha-synuclein simultaneously and may provide lead structures for the development of other compounds for the treatment of PD.	Caffeine	0-8	synuclein alpha	Homo sapiens	34-49
25530717-4	2014	MATERIALS AND METHODS: The PI3K inhibitors caffeine and wortmannin were used in an effort to identify the kinase(s) responsible for GAA -induced gammaH2AX in MEC-1 cells.	Caffeine	43-51	glucosidase, alpha, acid	Mus musculus	132-135
25530717-4	2014	MATERIALS AND METHODS: The PI3K inhibitors caffeine and wortmannin were used in an effort to identify the kinase(s) responsible for GAA -induced gammaH2AX in MEC-1 cells.	Caffeine	43-51	H2A.X variant histone	Mus musculus	145-154
25530717-4	2014	MATERIALS AND METHODS: The PI3K inhibitors caffeine and wortmannin were used in an effort to identify the kinase(s) responsible for GAA -induced gammaH2AX in MEC-1 cells.	Caffeine	43-51	ATR serine/threonine kinase	Homo sapiens	158-163
25530717-9	2014	Caffeine and wortmannin significantly inhibited GAA-induced H2AX phosphorylation in MEC-1 cells.	Caffeine	0-8	glucosidase, alpha, acid	Mus musculus	48-51
25530717-9	2014	Caffeine and wortmannin significantly inhibited GAA-induced H2AX phosphorylation in MEC-1 cells.	Caffeine	0-8	H2A.X variant histone	Mus musculus	60-64
25530717-9	2014	Caffeine and wortmannin significantly inhibited GAA-induced H2AX phosphorylation in MEC-1 cells.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	84-89
25160990-5	2014	EXPERIMENTAL APPROACH: We examined whether chronic or transient application of caffeine affects circadian period/amplitude and phase by evaluating bioluminescence rhythm in PER2::LUCIFERASE knock-in mice.	Caffeine	79-87	period circadian clock 2	Mus musculus	173-177
25538864-10	2014	In addition, A2AR is downregulated and desensitized in the maternal heart, suggesting a differential modulation of these receptor-mediated pathways by caffeine.	Caffeine	151-159	adenosine A2a receptor	Rattus norvegicus	13-17
25323389-8	2014	Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine.	Caffeine	129-137	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
25323389-8	2014	Expression levels of c-Fos and NGF in all central micturition areas were significantly increased following the administration of caffeine.	Caffeine	129-137	nerve growth factor	Rattus norvegicus	31-34
25323389-9	2014	The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine.	Caffeine	141-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-96
25323389-9	2014	The effects on contraction pressure and time were the most potent and expression levels of c-Fos and NGF were greatest at the lowest dose of caffeine.	Caffeine	141-149	nerve growth factor	Rattus norvegicus	101-104
25268872-2	2014	The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral antagonist or an inverse agonist is unresolved.	Caffeine	23-31	adenosine A2a receptor	Mus musculus	99-121
25268872-2	2014	The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral antagonist or an inverse agonist is unresolved.	Caffeine	23-31	adenosine A2a receptor	Mus musculus	123-127
25268872-3	2014	Here we show that caffeine is an A2AR inverse agonist in cell-based functional studies and in experimental parkinsonism.	Caffeine	18-26	adenosine A2a receptor	Mus musculus	33-37
25268872-6	2014	Overall, caffeine A2AR inverse agonism may be behind some of the well-known physiological effects of this substance both in health and disease.	Caffeine	9-17	adenosine A2a receptor	Mus musculus	18-22
25260559-0	2014	Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling.	Caffeine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
25260559-0	2014	Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling.	Caffeine	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	124-128
25260559-7	2014	The results of this study demonstrated that caffeine suppressed exercise-enhanced long-term (ORT) and spatial (OLT) memory in middle-aged and this effect may be related to a decrease in hippocampal p-CREB signaling.	Caffeine	44-52	cAMP responsive element binding protein 1	Rattus norvegicus	200-204
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	140-144
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	146-150
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	myosin, heavy chain 7B, cardiac muscle, beta	Mus musculus	152-157
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	troponin I, cardiac 3	Mus musculus	159-164
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	natriuretic peptide type A	Mus musculus	183-186
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	natriuretic peptide type B	Mus musculus	191-194
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	GATA binding protein 4	Mus musculus	228-233
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	myocyte enhancer factor 2C	Mus musculus	235-240
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	myocyte enhancer factor 2D	Mus musculus	242-247
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	249-255
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	microRNA 208a	Mus musculus	281-288
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	microRNA 208b	Mus musculus	290-297
25354728-3	2014	In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499).	Caffeine	46-54	microRNA 499	Mus musculus	299-305
25263335-8	2014	Treatment with the RyR agonist caffeine (1 mmol/L) significantly increased Ca(2+) release in VSMCs exposed to hypoxia for 10 min or 3 h, which was partially antagonized by transfection with RyR2 siRNA.	Caffeine	31-39	ryanodine receptor 2	Rattus norvegicus	190-194
25193633-9	2014	Digoxin had similar effects to caffeine, another SRSF3-reduced agent, on the cell cycle profile and DNA damage of cells.	Caffeine	31-39	serine and arginine rich splicing factor 3	Homo sapiens	49-54
25540004-6	2014	Caffeine increased the activities of antioxidant enzymes (SOD, GPx, CAT, GST), AST, ALT, ALP, neutral proteases, and protease inhibitors, and the concentrations of uric acid, triglycerides, cholesterol, glucose, and Ca2+.	Caffeine	0-8	Cat	Apis mellifera	68-71
25540004-6	2014	Caffeine increased the activities of antioxidant enzymes (SOD, GPx, CAT, GST), AST, ALT, ALP, neutral proteases, and protease inhibitors, and the concentrations of uric acid, triglycerides, cholesterol, glucose, and Ca2+.	Caffeine	0-8	kinectin	Apis mellifera	84-87
25342885-10	2014	The inhibition of the expression of beta1-integrin and insulin-like growth factor receptor in fibroblasts incubated with the caffeine indicates a possible mechanism of inhibition of collagen biosynthesis.	Caffeine	125-133	integrin subunit beta 1	Homo sapiens	36-50
25019206-1	2014	Chronic treatment with caffeine, the most widely consumed psychoactive drug and a non-selective antagonist of adenosine receptors, can protection against myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).	Caffeine	23-31	myelin oligodendrocyte glycoprotein	Mus musculus	154-189
25019206-1	2014	Chronic treatment with caffeine, the most widely consumed psychoactive drug and a non-selective antagonist of adenosine receptors, can protection against myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).	Caffeine	23-31	myelin oligodendrocyte glycoprotein	Mus musculus	191-194
25019206-2	2014	In this study, we investigated the mechanism underlying caffeine-mediated neuroprotection against EAE by determining the effective therapeutic time-window of caffeine and the involvement of adenosine A2A and A1 receptor.	Caffeine	56-64	adenosine A2a receptor	Mus musculus	190-219
25019206-4	2014	Furthermore, genetic deletion of the A2AR exacerbated MOG-induced brain damage and caffeine administering to A2AR knockout mice reversed this EAE pathology by acting at non-A2AR target.	Caffeine	83-91	adenosine A2a receptor	Mus musculus	109-113
25019206-4	2014	Furthermore, genetic deletion of the A2AR exacerbated MOG-induced brain damage and caffeine administering to A2AR knockout mice reversed this EAE pathology by acting at non-A2AR target.	Caffeine	83-91	adenosine A2a receptor	Mus musculus	109-113
24836650-8	2014	Caffeine counteracted testosterone-enhanced TGF-beta2 protein expression in male HFs.	Caffeine	0-8	transforming growth factor beta 2	Homo sapiens	44-53
24836650-10	2014	In male and female HFs, caffeine enhanced IGF-1 protein expression.	Caffeine	24-32	insulin like growth factor 1	Homo sapiens	42-47
24836650-11	2014	In ORSKs, caffeine stimulated cell proliferation, inhibited apoptosis/necrosis, and upregulated IGF-1 gene expression and protein secretion, while TGF-beta2 protein secretion was downregulated.	Caffeine	10-18	insulin like growth factor 1	Homo sapiens	96-101
25268764-5	2014	Additional experiments using pharmacological inhibitors and RNA interference (RNAi) demonstrated that the calcium/calmodulin-activated protein kinases CaMKKbeta and CaMKII contributed to the AMPK-dependent expression of LC3b-II and autophagic vesicle accumulation in a caffeine dose-dependent manner.	Caffeine	269-277	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	151-171
25293551-6	2014	Both caffeine-induced performance enhancement and insulin resistance converge with the primary actions of caffeine on skeletal muscle.	Caffeine	106-114	insulin	Homo sapiens	50-57
24890676-7	2014	In a rat pancreatic beta-cell line Rin-5f cells, caffeine downregulated expression of one of the proteins involved in insulin synthesis, P4hb, and there was reduced transcriptional expression of insulin.	Caffeine	49-57	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	137-141
25381781-7	2014	However, Osteocalcin and CTX were higher in women preferring caffeine intake, sedentary lifestyle and alcoholic drinks.	Caffeine	61-69	bone gamma-carboxyglutamate protein	Homo sapiens	9-20
25381781-7	2014	However, Osteocalcin and CTX were higher in women preferring caffeine intake, sedentary lifestyle and alcoholic drinks.	Caffeine	61-69	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	25-28
25201308-6	2014	The activities of carnitine acyltransferase (CAT) and acyl-CoA oxidase (ACO) were increased in mice fed the caffeine and CGA+caffeine diets, while the activity of fatty acid synthase (FAS) was suppressed in those fed the CGA+caffeine diet.	Caffeine	108-116	fatty acid synthase	Mus musculus	163-182
25088042-7	2014	Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17alpha-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor.	Caffeine	245-253	solute carrier organic anion transporter family, member 1D1	Danio rerio	0-7
25201308-6	2014	The activities of carnitine acyltransferase (CAT) and acyl-CoA oxidase (ACO) were increased in mice fed the caffeine and CGA+caffeine diets, while the activity of fatty acid synthase (FAS) was suppressed in those fed the CGA+caffeine diet.	Caffeine	108-116	fatty acid synthase	Mus musculus	184-187
25201308-8	2014	The protein expression levels of AMPK were increased and those of FAS were decreased in mice fed the CGA+caffeine diet.	Caffeine	105-113	fatty acid synthase	Mus musculus	66-69
25031227-9	2014	Immunostaining showed a significantly elevated number of c-Fos-labeled histamine neurons in caffeine-treated rats compared with saline-treated animals.	Caffeine	92-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
25229238-7	2014	In particular, the differentiated MLC/mIGF-1 transgenic myotubes have reduced velocity and amplitude of intracellular Ca2+ increases after stimulation with caffeine, KCl and acetylcholine.	Caffeine	156-164	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	34-37
25229238-7	2014	In particular, the differentiated MLC/mIGF-1 transgenic myotubes have reduced velocity and amplitude of intracellular Ca2+ increases after stimulation with caffeine, KCl and acetylcholine.	Caffeine	156-164	insulin-like growth factor 1	Mus musculus	38-44
25193700-8	2014	ECG telemetry revealed that various types of arrhythmias were induced in RyR2(R420W/R420W) mice in response to administration of caffeine and adrenaline.	Caffeine	129-137	ryanodine receptor 2, cardiac	Mus musculus	73-77
24972488-4	2014	In addition, the RyR1 agonists 4-CMC and caffeine activated Ca(2+) release that was inhibited by high concentrations of ryanodine.	Caffeine	41-49	ryanodine receptor 1	Homo sapiens	17-21
25093688-4	2014	The experimental results showed that the total protein contents, the surface area of cardiomyocyte and beta-myosin heavy chain (beta-MHC) expression increased in ventricular myocytes of neonatal Sprague-Dawley (SD) rats after 24h caffeine incubation.	Caffeine	230-238	myosin heavy chain 7	Rattus norvegicus	103-126
25093688-4	2014	The experimental results showed that the total protein contents, the surface area of cardiomyocyte and beta-myosin heavy chain (beta-MHC) expression increased in ventricular myocytes of neonatal Sprague-Dawley (SD) rats after 24h caffeine incubation.	Caffeine	230-238	myosin heavy chain 7	Rattus norvegicus	128-136
25093688-6	2014	The caffeine-induced myocyte enhancer factor-2 (MEF2) expression and hypertrophy can be completely abolished by the inhibition of cardiac ryanodine receptor (RyR2), as well as KN93 and curcumin treatments.	Caffeine	4-12	ryanodine receptor 2	Rattus norvegicus	158-162
24798323-7	2014	In contrast, caffeine (100 microM), abolished the [Ca(2+)]i response induced by bradykinin (3 microM), but did not affect the [Ca(2+)]i increase induced by histamine (100 microM).	Caffeine	13-21	kininogen 1	Bos taurus	80-90
24780254-0	2014	Beneficial effects of caffeine in a transgenic model of Alzheimer"s disease-like tau pathology.	Caffeine	22-30	microtubule associated protein tau	Homo sapiens	81-84
24780254-6	2014	We found that chronic caffeine intake prevents from the development of spatial memory deficits in tau mice.	Caffeine	22-30	microtubule associated protein tau	Homo sapiens	98-101
24780254-9	2014	Together, our data support that moderate caffeine intake is beneficial in a model of AD-like tau pathology, paving the way for future clinical evaluation in AD patients.	Caffeine	41-49	microtubule associated protein tau	Homo sapiens	93-96
25148524-3	2014	Traditionally, such defects were studied in human and equine subjects by examining the contractile responses of biopsied muscle strips exposed to caffeine, a potent RYR1 agonist.	Caffeine	146-154	ryanodine receptor 1	Equus caballus	165-169
25229010-0	2014	Caffeine Effects on ERP Components and Performance in an Equiprobable Auditory Go/NoGo Task.	Caffeine	0-8	reticulon 4	Homo sapiens	82-86
23925589-0	2014	Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells.	Caffeine	5-13	chitinase-like 1	Mus musculus	70-88
24980692-4	2014	In this study, caffeine and paraxanthine are determined in capillary DBS, venous DBS, whole blood and plasma for cytochrome P450 (CYP) 1A2 phenotyping.	Caffeine	15-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	113-138
23925589-7	2014	RESULTS: In vitro, caffeine treatment in IEC lines down-regulated CHI3L1 mRNA expression, which resulted in the reduction of bacterial invasion in a caffeine dose-dependent manner.	Caffeine	19-27	chitinase-like 1	Mus musculus	66-72
23925589-7	2014	RESULTS: In vitro, caffeine treatment in IEC lines down-regulated CHI3L1 mRNA expression, which resulted in the reduction of bacterial invasion in a caffeine dose-dependent manner.	Caffeine	149-157	chitinase-like 1	Mus musculus	66-72
23925589-10	2014	Caffeine treatment also resulted in the loss of CHI3L1-associated AKT signaling pathway activation both in vitro and in vivo.	Caffeine	0-8	chitinase-like 1	Mus musculus	48-54
24948078-3	2014	METHODS: MDMA was given in doses of 20 and 40mg/kg ip alone or in combination with caffeine (CAF) 10mg/kg ip.	Caffeine	83-91	caffeine susceptibility	Mus musculus	93-96
24862851-7	2014	Cortical BDNF at E18 was decreased by caffeine (1.0 g/L), while it increased at E20, with no major effects on TrkB receptors.	Caffeine	38-46	brain-derived neurotrophic factor	Rattus norvegicus	9-13
24862851-8	2014	In the hippocampus, caffeine decreased TrkB receptor only at E18, with no effects on BDNF.	Caffeine	20-28	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	39-43
24862851-9	2014	Moderate and high doses of caffeine promoted an increase in Shh in both brain regions at E18, and in the hippocampus at E20.	Caffeine	27-35	sonic hedgehog signaling molecule	Rattus norvegicus	60-63
24862851-10	2014	Caffeine (0.3g/L) decreased GAP-43 only in the hippocampus at E18.	Caffeine	0-8	growth associated protein 43	Rattus norvegicus	28-34
24862851-13	2014	The increased number of NeuN-stained nuclei by prenatal caffeine suggests a possible acceleration of the telencephalon maturation.	Caffeine	56-64	RNA binding fox-1 homolog 3	Rattus norvegicus	24-28
25075865-0	2014	Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption.	Caffeine	81-89	aryl hydrocarbon receptor	Homo sapiens	52-55
24907695-10	2014	Acute, but not chronic, caffeine exposure elevated c-Fos expression in the NAc.	Caffeine	24-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
25075865-0	2014	Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption.	Caffeine	81-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	60-66
24836454-0	2014	Absorption of caffeine in fermented Pu-er tea is inhibited in mice.	Caffeine	14-22	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	42-45
24836454-7	2014	Congruent with this result, the amount of caffeine detected in mice excrement showed that more caffeine was eliminated in the caffeine/OTP group and the Pu-er tea group.	Caffeine	95-103	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	159-162
24836454-2	2014	Although its pharmacokinetics has been intensively explored, little is known about complexed caffeine (C-CAF) in aqueous extraction of fermented Pu-er tea.	Caffeine	93-101	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	151-154
24836454-7	2014	Congruent with this result, the amount of caffeine detected in mice excrement showed that more caffeine was eliminated in the caffeine/OTP group and the Pu-er tea group.	Caffeine	95-103	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	159-162
24836454-7	2014	Congruent with this result, the amount of caffeine detected in mice excrement showed that more caffeine was eliminated in the caffeine/OTP group and the Pu-er tea group.	Caffeine	42-50	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	159-162
24836454-8	2014	The locomotor activity tests of mice demonstrated that the stimulating effect of caffeine in caffeine/OTP and Pu-er tea was weaker than in coffee.	Caffeine	81-89	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	116-119
24628114-7	2014	2-aminoethoxydiphenyl borate (2-APB) and high concentrations of caffeine selectively inhibited IP3R1 without affecting IP3 binding.	Caffeine	64-72	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	95-100
24717552-0	2014	Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis.	Caffeine	9-17	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	88-110
24717552-8	2014	Furthermore, caffeine reduced both the protein and the mRNA expression of SF-1 in the fetal adrenal.	Caffeine	13-21	splicing factor 1	Rattus norvegicus	74-78
24717552-9	2014	The epigenetic analysis showed that caffeine treatment can significantly enhance the mRNA expression of DNA methyltransferase (Dnmt) 1, Dnmt3a, histone deacetylases (Hdac) 1, and Hdac2.	Caffeine	36-44	DNA methyltransferase 1	Rattus norvegicus	104-134
24717552-9	2014	The epigenetic analysis showed that caffeine treatment can significantly enhance the mRNA expression of DNA methyltransferase (Dnmt) 1, Dnmt3a, histone deacetylases (Hdac) 1, and Hdac2.	Caffeine	36-44	DNA methyltransferase 3 alpha	Rattus norvegicus	136-142
24717552-9	2014	The epigenetic analysis showed that caffeine treatment can significantly enhance the mRNA expression of DNA methyltransferase (Dnmt) 1, Dnmt3a, histone deacetylases (Hdac) 1, and Hdac2.	Caffeine	36-44	histone deacetylase 1	Rattus norvegicus	144-173
24717552-9	2014	The epigenetic analysis showed that caffeine treatment can significantly enhance the mRNA expression of DNA methyltransferase (Dnmt) 1, Dnmt3a, histone deacetylases (Hdac) 1, and Hdac2.	Caffeine	36-44	histone deacetylase 2	Rattus norvegicus	179-184
24717552-12	2014	In conclusion, prenatal caffeine ingestion is able to induce aberrant DNA methylation and histone acetylation of the SF-1 promoter in the rat fetal adrenal.	Caffeine	24-32	splicing factor 1	Rattus norvegicus	117-121
24318358-2	2014	We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine.	Caffeine	194-202	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131
24628114-11	2014	Practicable concentrations of caffeine and 2-APB inhibit only IP3R1.	Caffeine	30-38	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	62-67
24677265-7	2014	Intracellular calcium (Ca(2+)) measurements of the siRNA-treated myotubes showed a decrease in maximal amplitude peak response to caffeine, suggesting that less Ca(2+) is available for release due to the partial silencing of Mettl21c, correlating with impaired myogenesis.	Caffeine	130-138	methyltransferase like 21C	Mus musculus	225-233
24785759-9	2014	In addition, complementation of FgERG3 and FgERG5 genes into S. cerevisiae partially rescued the susceptibility of S. cerevisiae ERG3 and ERG5 deletion mutants towards hydroxyurea and caffeine.	Caffeine	184-192	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	34-38
24785759-9	2014	In addition, complementation of FgERG3 and FgERG5 genes into S. cerevisiae partially rescued the susceptibility of S. cerevisiae ERG3 and ERG5 deletion mutants towards hydroxyurea and caffeine.	Caffeine	184-192	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	45-49
24380444-0	2014	High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.	Caffeine	45-53	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	5-11
24753179-5	2014	We found that the ES-induced BDNF release required calcium influx through T-type voltage-gated calcium channel (VGCC) and calcium mobilization from internal calcium stores, including inositol triphosphate-sensitive stores and caffeine/ryanodine-sensitive stores.	Caffeine	226-234	brain derived neurotrophic factor	Homo sapiens	29-33
24915238-0	2014	Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson"s disease in Swedish population.	Caffeine	0-8	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	50-56
24909770-3	2014	Meanwhile, the electrochemical performance of the glassy carbon electrode (GCE) modified with electrodeposited NGR-NCNTs (ENGR-NCNTs/GCE) towards caffeine (CAF) and vanillin (VAN) determination was demonstrated by cyclic voltammetry (CV) and square wave voltammetry (SWV).	Caffeine	146-154	reticulon 4 receptor	Homo sapiens	111-114
24909770-3	2014	Meanwhile, the electrochemical performance of the glassy carbon electrode (GCE) modified with electrodeposited NGR-NCNTs (ENGR-NCNTs/GCE) towards caffeine (CAF) and vanillin (VAN) determination was demonstrated by cyclic voltammetry (CV) and square wave voltammetry (SWV).	Caffeine	156-159	reticulon 4 receptor	Homo sapiens	111-114
24726984-5	2014	All tested doses of caffeine decreased the density of glial fibrillary acidic protein and synaptosomal-associated protein-25, but failed to modify neuron-specific nuclear protein immunoreactivity in the hippocampus and cerebral cortex.	Caffeine	20-28	synaptosome associated protein 25	Rattus norvegicus	90-124
24726984-6	2014	Caffeine (0.3-1mg/mL) increased the density of brain-derived neurotrophic factor (BDNF) and proBDNF density as well as adenosine A1 receptor density in the hippocampus, whereas the higher dose of caffeine (1mg/mL) increased the density of proBDNF and BDNF and decreased A1 receptor density in the cerebral cortex.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	47-80
24726984-6	2014	Caffeine (0.3-1mg/mL) increased the density of brain-derived neurotrophic factor (BDNF) and proBDNF density as well as adenosine A1 receptor density in the hippocampus, whereas the higher dose of caffeine (1mg/mL) increased the density of proBDNF and BDNF and decreased A1 receptor density in the cerebral cortex.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	82-86
24726984-6	2014	Caffeine (0.3-1mg/mL) increased the density of brain-derived neurotrophic factor (BDNF) and proBDNF density as well as adenosine A1 receptor density in the hippocampus, whereas the higher dose of caffeine (1mg/mL) increased the density of proBDNF and BDNF and decreased A1 receptor density in the cerebral cortex.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	95-99
24726984-7	2014	These findings document an impact of caffeine consumption in adolescent rats with a dual impact on anxiety and recognition memory, associated with changes in BDNF levels and decreases of astrocytic and nerve terminal markers without overt neuronal damage in hippocampal and cortical regions.	Caffeine	37-45	brain-derived neurotrophic factor	Rattus norvegicus	158-162
25073400-5	2014	RESULTS: The activity of CYP1A2 in rats was inhibited significantly after treatment with scutellarin by increased caffeine t1/2 (21.76%, P &lt; 0.05), T(max) (43.05%, P &lt; 0.05), C(max) (43.92%, P &lt; 0.01) and AUC(0-infinity) (50.88%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	Caffeine	114-122	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	25-31
24972086-6	2014	Caffeine suppressed nocodazole induced G2/M arrest indicating involvement of the ATM/ATR.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	85-88
24915238-2	2014	A recent genome-wide association and interaction study (GWAIS) identified GRIN2A, which encodes an NMDA-glutamate-receptor subunit involved in brain"s excitatory neurotransmission, as a PD genetic modifier in inverse association with caffeine intake.	Caffeine	234-242	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	74-80
24444450-7	2014	The ACR-induced increases in the levels of p53 and pp53 in primary astrocytes could be attenuated by caffeine.	Caffeine	101-109	tumor protein p53	Homo sapiens	43-46
24400695-9	2014	At normal Mg(2+), IL-1alpha reversibly increased caffeine-induced force and Ca(2+) transients.	Caffeine	49-57	interleukin 1 alpha	Homo sapiens	18-27
24636305-5	2014	Secondly, caffeine exposure perturbed Pax6 expression in the retina of the developing eye.	Caffeine	10-18	paired box 6	Gallus gallus	38-42
24828686-0	2014	Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells.	Caffeine	0-8	transforming growth factor beta 1	Homo sapiens	49-58
24699176-0	2014	Caffeine attenuated ER stress-induced leptin resistance in neurons.	Caffeine	0-8	leptin	Homo sapiens	38-44
24699176-7	2014	In the present study, we investigated whether caffeine could affect ER stress and the subsequent development of leptin resistance.	Caffeine	46-54	leptin	Homo sapiens	112-118
24699176-9	2014	Caffeine also inhibited the ER stress-induced activation of IRE1 and PERK, which suggested the attenuation of ER stress.	Caffeine	0-8	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	60-64
24699176-9	2014	Caffeine also inhibited the ER stress-induced activation of IRE1 and PERK, which suggested the attenuation of ER stress.	Caffeine	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	69-73
24699176-10	2014	Moreover, caffeine markedly improved ER stress-induced impairments in the leptin-induced phosphorylation of STAT3.	Caffeine	10-18	leptin	Homo sapiens	74-80
24699176-10	2014	Moreover, caffeine markedly improved ER stress-induced impairments in the leptin-induced phosphorylation of STAT3.	Caffeine	10-18	signal transducer and activator of transcription 3	Homo sapiens	108-113
24699176-11	2014	Therefore, these results suggest caffeine may have pharmacological properties that ameliorate leptin resistance by reducing ER stress.	Caffeine	33-41	leptin	Homo sapiens	94-100
24828686-0	2014	Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells.	Caffeine	0-8	cellular communication network factor 2	Homo sapiens	70-74
24828686-0	2014	Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells.	Caffeine	0-8	transgelin	Homo sapiens	79-89
24828686-6	2014	The aim of the present study was to clarify whether caffeine, an unspecific phosphodiesterase (PDE) inhibitor, and rolipram, a prototypical PDE-4 selective inhibitor, were both able to affect TGF-beta1-induced Smad signalling and CTGF/transgelin expression in lung epithelial cells.	Caffeine	52-60	phosphodiesterase 4A	Homo sapiens	140-145
24828686-6	2014	The aim of the present study was to clarify whether caffeine, an unspecific phosphodiesterase (PDE) inhibitor, and rolipram, a prototypical PDE-4 selective inhibitor, were both able to affect TGF-beta1-induced Smad signalling and CTGF/transgelin expression in lung epithelial cells.	Caffeine	52-60	transforming growth factor beta 1	Homo sapiens	192-201
24828686-6	2014	The aim of the present study was to clarify whether caffeine, an unspecific phosphodiesterase (PDE) inhibitor, and rolipram, a prototypical PDE-4 selective inhibitor, were both able to affect TGF-beta1-induced Smad signalling and CTGF/transgelin expression in lung epithelial cells.	Caffeine	52-60	cellular communication network factor 2	Homo sapiens	230-234
24828686-6	2014	The aim of the present study was to clarify whether caffeine, an unspecific phosphodiesterase (PDE) inhibitor, and rolipram, a prototypical PDE-4 selective inhibitor, were both able to affect TGF-beta1-induced Smad signalling and CTGF/transgelin expression in lung epithelial cells.	Caffeine	52-60	transgelin	Homo sapiens	235-245
24828686-8	2014	The pharmacological effect of caffeine and rolipram on Smad signalling was investigated by means of a luciferase assay via transfection of a TGF-beta1-inducible reporter plasmid in A549 cells.	Caffeine	30-38	transforming growth factor beta 1	Homo sapiens	141-150
24828686-9	2014	The regulation of CTGF and transgelin expression by caffeine and rolipram were studied by promoter analysis, real-time PCR and Western blot.	Caffeine	52-60	cellular communication network factor 2	Homo sapiens	18-22
24828686-9	2014	The regulation of CTGF and transgelin expression by caffeine and rolipram were studied by promoter analysis, real-time PCR and Western blot.	Caffeine	52-60	transgelin	Homo sapiens	27-37
24828686-11	2014	The addition of caffeine and rolipram inhibited TGF-beta1 induced reporter gene activity in a concentration-related manner.	Caffeine	16-24	transforming growth factor beta 1	Homo sapiens	48-57
24481487-6	2014	The two-way ANOVA of pro-inflammatory cytokine levels demonstrated a significant exercise x caffeine interaction for IL-1beta (F (1, 16) = 9.5772; p = 0.0069), IL-6 (F (1, 16) = 8.0463; p = 0.0119) and INF-gamma (F (1, 16) = 15.078; p = 0.0013).	Caffeine	92-100	interleukin 1 beta	Rattus norvegicus	117-125
24828686-14	2014	The present study highlights possible new molecular mechanisms of caffeine and rolipram including an inhibition of Smad signalling and of TGF-beta1 regulated genes involved in airway remodelling.	Caffeine	66-74	transforming growth factor beta 1	Homo sapiens	138-147
24481487-6	2014	The two-way ANOVA of pro-inflammatory cytokine levels demonstrated a significant exercise x caffeine interaction for IL-1beta (F (1, 16) = 9.5772; p = 0.0069), IL-6 (F (1, 16) = 8.0463; p = 0.0119) and INF-gamma (F (1, 16) = 15.078; p = 0.0013).	Caffeine	92-100	interleukin 6	Rattus norvegicus	160-164
24763113-8	2014	Additionally, caffeine intake alone and combined with exercise decreased the plasma AChE and MPO activities.	Caffeine	14-22	acetylcholinesterase	Rattus norvegicus	84-88
24481487-7	2014	The two-way ANOVA of TNF-alpha levels revealed a significant exercise x caffeine interaction (F (1, 16) = 9.6881; p = 0.00670).	Caffeine	72-80	tumor necrosis factor	Rattus norvegicus	21-30
24313346-1	2014	OBJECTIVES: Caffeine represents a useful scaffold for the design of monoamine oxidase (MAO) type B inhibitors.	Caffeine	12-20	monoamine oxidase B	Homo sapiens	68-98
24313346-3	2014	To explore the structure-activity relationships of MAO-B inhibition by caffeine-derived compounds, this study examines the MAO inhibitory properties of a series of phenylalkylcaffeine analogues.	Caffeine	71-79	monoamine oxidase B	Homo sapiens	51-56
24313346-4	2014	METHODS: Employing the recombinant human enzymes, the potencies (IC50 values) by which the caffeine analogues inhibit MAO-A and MAO-B were measured.	Caffeine	91-99	monoamine oxidase A	Homo sapiens	118-123
24313346-4	2014	METHODS: Employing the recombinant human enzymes, the potencies (IC50 values) by which the caffeine analogues inhibit MAO-A and MAO-B were measured.	Caffeine	91-99	monoamine oxidase B	Homo sapiens	128-133
24525422-9	2014	In addition, caffeine treatment also decreased the number of immunopositive cells for HDAC and pro-inflammatory cytokines TNF-alpha and IL-1beta.	Caffeine	13-21	tumor necrosis factor	Rattus norvegicus	122-131
24525422-9	2014	In addition, caffeine treatment also decreased the number of immunopositive cells for HDAC and pro-inflammatory cytokines TNF-alpha and IL-1beta.	Caffeine	13-21	interleukin 1 alpha	Rattus norvegicus	136-144
24521981-0	2014	Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	104-107
24521981-4	2014	We demonstrate that caffeine and CGS 15943 block proliferation in HCC and PDAC cell lines by inhibiting the PI3K/Akt pathway.	Caffeine	20-28	AKT serine/threonine kinase 1	Homo sapiens	113-116
24637215-10	2014	(PhSe)2-supplemented diet associated to the administration of caffeine improved long-term memory impaired in middle-aged rats, an effect independent of CREB and Akt phosphorylation.	Caffeine	62-70	cAMP responsive element binding protein 1	Rattus norvegicus	152-156
24464430-6	2014	Immunocytochemistry and Western blot results demonstrated that 10(-5) M BK could cause the internalization and a decrease in the expression of claudin-5; agonists of IP3 Rs and RyRs, such as IP3 and caffeine, enhanced the BK-induced downregulation of claudin-5, whereas antagonists of IP3 Rs and RyRs, such as 2-APB and ryanodine, abrogated BK"s effect on claudin-5.	Caffeine	199-207	claudin 5	Rattus norvegicus	143-152
24172719-12	2014	Carbohydrate and caffeine consumption before endurance cycling significantly increased the IL-6 release and leukocytosis, and the additional ingredients in ED seem to have further augmented these responses.	Caffeine	17-25	interleukin 6	Homo sapiens	91-95
24568740-6	2014	Ryanodine receptor (RyR) refractoriness played a key role in the onset of SR Ca(2+) alternans, with SR Ca(2+) release alternans routinely occurring without changes in diastolic [Ca(2+)]SR. Sensitizing RyR with caffeine (200 mumol/L) significantly reduced the pacing threshold for both SR Ca(2+) and APD alternans (188+-15 and 173+-12 ms; P&lt;0.05 versus baseline).	Caffeine	210-218	LOC100009439	Oryctolagus cuniculus	0-18
24568740-6	2014	Ryanodine receptor (RyR) refractoriness played a key role in the onset of SR Ca(2+) alternans, with SR Ca(2+) release alternans routinely occurring without changes in diastolic [Ca(2+)]SR. Sensitizing RyR with caffeine (200 mumol/L) significantly reduced the pacing threshold for both SR Ca(2+) and APD alternans (188+-15 and 173+-12 ms; P&lt;0.05 versus baseline).	Caffeine	210-218	LOC100009439	Oryctolagus cuniculus	20-23
24763113-8	2014	Additionally, caffeine intake alone and combined with exercise decreased the plasma AChE and MPO activities.	Caffeine	14-22	myeloperoxidase	Rattus norvegicus	93-96
24966912-5	2014	Nuclear localized NF-E2-related factor 2 (Nrf2) was increased in HBX-expressing cells exposed to H2O2, but remained at lower levels after the treatment with rottlerin, KU55933, or caffeine.	Caffeine	180-188	NFE2 like bZIP transcription factor 2	Homo sapiens	18-40
24747296-5	2014	The activation of RyR2 by caffeine increased the IK,Ca in the cardiac cells (p&lt;0.05, p&lt;0.01, respectively).	Caffeine	26-34	ryanodine receptor 2, cardiac	Mus musculus	18-22
24966912-5	2014	Nuclear localized NF-E2-related factor 2 (Nrf2) was increased in HBX-expressing cells exposed to H2O2, but remained at lower levels after the treatment with rottlerin, KU55933, or caffeine.	Caffeine	180-188	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
24676319-8	2014	Given the enormous economic and emotional toll threatened by the current epidemic of Alzheimer"s disease and other dementias, it is critically important to validate potential prevention strategies such as coffee and caffeine.	Caffeine	216-224	toll like receptor 4	Homo sapiens	42-46
24612062-3	2014	The results indicate disturbed barrier function as demonstrated by increased permeation of testosterone and caffeine particularly in TGM1 knock-down models compared to control models.	Caffeine	108-116	transglutaminase 1	Homo sapiens	133-137
24423447-2	2014	Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" manner, no single-channel study confirmed this assumption.	Caffeine	86-94	ryanodine receptor 1	Homo sapiens	48-66
24423447-2	2014	Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" manner, no single-channel study confirmed this assumption.	Caffeine	86-94	ryanodine receptor 1	Homo sapiens	68-71
24423447-6	2014	At the single-channel level, MBED mimicked the agonistic action of caffeine on cardiac RyR gating (i.e., stabilized long openings characteristic of "high-open-probability" mode).	Caffeine	67-75	ryanodine receptor 1	Homo sapiens	87-90
23929677-6	2014	Furthermore, caffeine-induced autophagy involved down-regulation of mammalian target of rapamycin signaling and alteration in hepatic amino acids and sphingolipid levels.	Caffeine	13-21	mechanistic target of rapamycin kinase	Homo sapiens	68-97
24682220-0	2014	Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway.	Caffeine	0-8	adenosine A2a receptor	Rattus norvegicus	87-109
24682220-7	2014	In addition, the inhibitory effect of caffeine on the expression of procollagen type I was regulated by A2AR-mediated signal pathway involving cAMP, PKA, SRC, and ERK1/2.	Caffeine	38-46	adenosine A2a receptor	Rattus norvegicus	104-108
24682220-0	2014	Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway.	Caffeine	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	135-138
24682220-7	2014	In addition, the inhibitory effect of caffeine on the expression of procollagen type I was regulated by A2AR-mediated signal pathway involving cAMP, PKA, SRC, and ERK1/2.	Caffeine	38-46	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	154-157
24682220-0	2014	Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway.	Caffeine	0-8	mitogen activated protein kinase 3	Rattus norvegicus	139-145
24682220-7	2014	In addition, the inhibitory effect of caffeine on the expression of procollagen type I was regulated by A2AR-mediated signal pathway involving cAMP, PKA, SRC, and ERK1/2.	Caffeine	38-46	mitogen activated protein kinase 3	Rattus norvegicus	163-169
24682220-8	2014	Interestingly, caffeine"s inhibitory effect on the expression of procollagen type III may depend upon the A2AR-mediated P38 MAPK-dependent pathway.	Caffeine	15-23	adenosine A2a receptor	Rattus norvegicus	106-110
24682220-0	2014	Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway.	Caffeine	0-8	mitogen activated protein kinase 14	Rattus norvegicus	146-149
24682220-8	2014	Interestingly, caffeine"s inhibitory effect on the expression of procollagen type III may depend upon the A2AR-mediated P38 MAPK-dependent pathway.	Caffeine	15-23	mitogen activated protein kinase 14	Rattus norvegicus	120-123
24682220-0	2014	Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway.	Caffeine	0-8	mitogen activated protein kinase 3	Rattus norvegicus	150-154
24682220-8	2014	Interestingly, caffeine"s inhibitory effect on the expression of procollagen type III may depend upon the A2AR-mediated P38 MAPK-dependent pathway.	Caffeine	15-23	mitogen activated protein kinase 3	Rattus norvegicus	124-128
24682220-9	2014	CONCLUSIONS: Caffeine significantly inhibited acetaldehyde-induced HSC-T6 cells activation by distinct A2AR mediated signal pathway via inhibition of cAMP-PKA-SRC-ERK1/2 for procollagen type I and via P38 MAPK for procollagen type III.	Caffeine	13-21	adenosine A2a receptor	Rattus norvegicus	103-107
24682220-4	2014	In this study, we attempted to validate the hypothesis that caffeine influences acetaldehyde-induced HSC activation by acting on A2AR.	Caffeine	60-68	adenosine A2a receptor	Rattus norvegicus	129-133
24682220-9	2014	CONCLUSIONS: Caffeine significantly inhibited acetaldehyde-induced HSC-T6 cells activation by distinct A2AR mediated signal pathway via inhibition of cAMP-PKA-SRC-ERK1/2 for procollagen type I and via P38 MAPK for procollagen type III.	Caffeine	13-21	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	159-162
24682220-9	2014	CONCLUSIONS: Caffeine significantly inhibited acetaldehyde-induced HSC-T6 cells activation by distinct A2AR mediated signal pathway via inhibition of cAMP-PKA-SRC-ERK1/2 for procollagen type I and via P38 MAPK for procollagen type III.	Caffeine	13-21	mitogen activated protein kinase 3	Rattus norvegicus	163-169
24206703-3	2014	A C18 reverse-phase mini-column was coupled to a continuous flow manifold to carry out the on-line SPE and the quantification of caffeine from aqueous extracts.	Caffeine	129-137	Bardet-Biedl syndrome 9	Homo sapiens	2-5
24682220-9	2014	CONCLUSIONS: Caffeine significantly inhibited acetaldehyde-induced HSC-T6 cells activation by distinct A2AR mediated signal pathway via inhibition of cAMP-PKA-SRC-ERK1/2 for procollagen type I and via P38 MAPK for procollagen type III.	Caffeine	13-21	mitogen activated protein kinase 14	Rattus norvegicus	201-204
24647340-10	2014	Since the hTAS2R43 receptor is sensible to caffeine, we verified if the detected variants produced differences in caffeine bitter perception on a subsample of people coming from the FVG cohort.	Caffeine	43-51	taste 2 receptor member 43	Homo sapiens	10-18
24647340-10	2014	Since the hTAS2R43 receptor is sensible to caffeine, we verified if the detected variants produced differences in caffeine bitter perception on a subsample of people coming from the FVG cohort.	Caffeine	114-122	taste 2 receptor member 43	Homo sapiens	10-18
24647340-11	2014	We found a significant association between differences in caffeine perception and the H212R variant but not with the W35S, which suggests that the effect of the TAS2R43 gene on coffee liking is mediated by caffeine and in particular by the H212R variant.	Caffeine	58-66	taste 2 receptor member 43	Homo sapiens	161-168
24647340-11	2014	We found a significant association between differences in caffeine perception and the H212R variant but not with the W35S, which suggests that the effect of the TAS2R43 gene on coffee liking is mediated by caffeine and in particular by the H212R variant.	Caffeine	206-214	taste 2 receptor member 43	Homo sapiens	161-168
24475784-1	2014	Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion.	Caffeine	245-251	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	cyclin dependent kinase inhibitor 2A	Homo sapiens	108-111
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	H3 histone pseudogene 16	Homo sapiens	113-116
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	tumor protein p53	Homo sapiens	118-121
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	caveolin 1	Homo sapiens	126-131
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	interleukin 6	Homo sapiens	192-196
24342283-0	2014	Adenovirus-mediated expression of myogenic differentiation factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes.	Caffeine	142-150	myogenic differentiation 1	Equus caballus	69-73
24475784-1	2014	Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion.	Caffeine	245-251	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	C-X-C motif chemokine ligand 12	Homo sapiens	208-213
24595168-4	2014	METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that caffeine up-regulates the tumor suppressor proteins p16, p21, p53 and Cav-1, and reduces the expression/secretion of various cytokines (IL-6, TGF-beta, SDF-1 and MMP-2), and down-regulates alpha-SMA.	Caffeine	56-64	matrix metallopeptidase 2	Homo sapiens	218-223
24595168-5	2014	Furthermore, caffeine suppressed the migratory/invasiveness abilities of CAF cells through PTEN-dependent Akt/Erk1/2 inactivation.	Caffeine	13-21	phosphatase and tensin homolog	Homo sapiens	91-95
24595168-5	2014	Furthermore, caffeine suppressed the migratory/invasiveness abilities of CAF cells through PTEN-dependent Akt/Erk1/2 inactivation.	Caffeine	13-21	AKT serine/threonine kinase 1	Homo sapiens	106-109
24595168-5	2014	Furthermore, caffeine suppressed the migratory/invasiveness abilities of CAF cells through PTEN-dependent Akt/Erk1/2 inactivation.	Caffeine	13-21	mitogen-activated protein kinase 3	Homo sapiens	110-116
24595168-8	2014	This has been confirmed by showing that caffeine also suppresses the paracrine pro-angiogenic effect of CAF cells through down-regulating HIF-1alphaand its downstream effector VEGF-A.	Caffeine	40-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-143
24595168-8	2014	This has been confirmed by showing that caffeine also suppresses the paracrine pro-angiogenic effect of CAF cells through down-regulating HIF-1alphaand its downstream effector VEGF-A.	Caffeine	40-48	vascular endothelial growth factor A	Homo sapiens	176-182
24366086-9	2014	Immunoblotting and immunofluorescence analyses further showed that caffeine reduced the fructose-induced phosphorylation of insulin receptor substrate 1 (IRS1(S307)) and reversed Akt(S473) and neuronal nitric oxide synthase phosphorylation.	Caffeine	67-75	insulin receptor substrate 1	Rattus norvegicus	124-152
24366086-9	2014	Immunoblotting and immunofluorescence analyses further showed that caffeine reduced the fructose-induced phosphorylation of insulin receptor substrate 1 (IRS1(S307)) and reversed Akt(S473) and neuronal nitric oxide synthase phosphorylation.	Caffeine	67-75	insulin receptor substrate 1	Rattus norvegicus	154-158
24366086-9	2014	Immunoblotting and immunofluorescence analyses further showed that caffeine reduced the fructose-induced phosphorylation of insulin receptor substrate 1 (IRS1(S307)) and reversed Akt(S473) and neuronal nitric oxide synthase phosphorylation.	Caffeine	67-75	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
24366086-12	2014	These results suggest that caffeine may enhance insulin receptor substrate 1-phosphatidylinositol 3-kinase-Akt-neuronal nitric oxide synthase signaling to decrease blood pressure by abolishing superoxide production in the NTS.	Caffeine	27-35	insulin receptor substrate 1	Rattus norvegicus	48-76
24366086-12	2014	These results suggest that caffeine may enhance insulin receptor substrate 1-phosphatidylinositol 3-kinase-Akt-neuronal nitric oxide synthase signaling to decrease blood pressure by abolishing superoxide production in the NTS.	Caffeine	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
24463096-6	2014	Caffeine administration reduced maternal weight gains and elevated both maternal and fetal corticosterone (CORT) levels.	Caffeine	0-8	cortistatin	Rattus norvegicus	107-111
24475784-1	2014	Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion.	Caffeine	245-251	acetylcholinesterase (Cartwright blood group)	Homo sapiens	212-216
24380689-6	2014	ATR knock down by siRNA or caffeine addition provoked increased cell death in both XP-V and XP-C cells exposed to low-dose of UVC, underscoring the involvement of ATR/Chk1 pathway in both DNA damage tolerance mechanisms.	Caffeine	27-35	DNA polymerase eta	Homo sapiens	83-87
24366314-0	2014	Caffeine induces behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript peptides in mice.	Caffeine	0-8	CART prepropeptide	Mus musculus	65-119
24366314-1	2014	This study examined whether repeated administration of caffeine would induce behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript (CART) peptides in mice.	Caffeine	55-63	CART prepropeptide	Mus musculus	125-179
24366314-1	2014	This study examined whether repeated administration of caffeine would induce behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript (CART) peptides in mice.	Caffeine	55-63	CART prepropeptide	Mus musculus	181-185
24366314-5	2014	Significant increases in CART mRNA levels were observed on day 3 and peaked at day 5 of caffeine administration, and then decreased gradually.	Caffeine	88-96	CART prepropeptide	Mus musculus	25-29
24366314-10	2014	Caffeine-induced overexpression of CART peptides was associated with the inhibition of A1R and A(2A)R, and the activation of cAMP/PKA/pCREB signalling.	Caffeine	0-8	CART prepropeptide	Mus musculus	35-39
24366314-11	2014	Moreover, the A(2A)R-D2R heterodimer might be involved in the overexpression of CART peptides induced by caffeine.	Caffeine	105-113	CART prepropeptide	Mus musculus	80-84
24754986-11	2014	CONCLUSIONS: Stimulatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS.Further studies are necessary to determine their roles in the pathogenesis of this disorder.	Caffeine	54-62	cholinergic receptor muscarinic 3	Homo sapiens	104-110
23339682-2	2014	METHODS: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively.	Caffeine	236-244	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	97-103
23339682-2	2014	METHODS: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively.	Caffeine	236-244	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	113-119
23339682-2	2014	METHODS: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively.	Caffeine	236-244	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	121-127
24380689-6	2014	ATR knock down by siRNA or caffeine addition provoked increased cell death in both XP-V and XP-C cells exposed to low-dose of UVC, underscoring the involvement of ATR/Chk1 pathway in both DNA damage tolerance mechanisms.	Caffeine	27-35	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	92-96
24380689-6	2014	ATR knock down by siRNA or caffeine addition provoked increased cell death in both XP-V and XP-C cells exposed to low-dose of UVC, underscoring the involvement of ATR/Chk1 pathway in both DNA damage tolerance mechanisms.	Caffeine	27-35	ATR serine/threonine kinase	Homo sapiens	163-166
24380689-6	2014	ATR knock down by siRNA or caffeine addition provoked increased cell death in both XP-V and XP-C cells exposed to low-dose of UVC, underscoring the involvement of ATR/Chk1 pathway in both DNA damage tolerance mechanisms.	Caffeine	27-35	checkpoint kinase 1	Homo sapiens	167-171
24275088-6	2014	A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group.	Caffeine	106-114	BCL2 associated X, apoptosis regulator	Rattus norvegicus	32-35
23903851-0	2014	Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-beta.	Caffeine	0-8	transforming growth factor, beta 1	Rattus norvegicus	76-84
23903851-10	2014	In addition, caffeine inhibits hepatic stellate cells because of blockade of the expression of alpha-smooth muscle actin; in the western blot assay, we also found low levels of mRNA of collagen alpha1.	Caffeine	13-21	actin gamma 2, smooth muscle	Rattus norvegicus	95-120
24361398-1	2014	AIMS: To investigate the role of the melanocortin (MC) system in the framework of the central nucleus of the amygdala (CeA) in the differential effects of the adenosine receptor blocker caffeine on anxiety-like behavior, using the social interaction (SI) test.	Caffeine	186-194	carcinoembryonic antigen gene family	Mus musculus	119-122
24333670-2	2014	The detailed mechanisms of caffeine in tumor suppression via tumor suppressor protein p53 remain unclear.	Caffeine	27-35	tumor protein p53	Homo sapiens	86-89
24333670-4	2014	In this study, we investigated how caffeine modulated cell cycle arrest and apoptosis via the expression of various alternatively spliced p53 isoforms.	Caffeine	35-43	tumor protein p53	Homo sapiens	138-141
24333670-5	2014	Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus.	Caffeine	0-8	tumor protein p53	Homo sapiens	17-20
24333670-5	2014	Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus.	Caffeine	0-8	tumor protein p53	Homo sapiens	67-70
24333670-7	2014	Serine/arginine-rich splicing factor 3 was a promising candidate for the serine/arginine-rich splicing factors responsible for the alternative splicing of p53 in response to caffeine treatment.	Caffeine	174-182	serine and arginine rich splicing factor 3	Homo sapiens	0-38
24333670-7	2014	Serine/arginine-rich splicing factor 3 was a promising candidate for the serine/arginine-rich splicing factors responsible for the alternative splicing of p53 in response to caffeine treatment.	Caffeine	174-182	tumor protein p53	Homo sapiens	155-158
24333670-8	2014	In addition to p53-dependent functions, multiple target genes of serine/arginine-rich splicing factor 3 suggest that caffeine can regulate epithelial-mesenchymal-transition and hypoxic conditions to inhibit the survival of tumor cells.	Caffeine	117-125	tumor protein p53	Homo sapiens	15-18
24333670-8	2014	In addition to p53-dependent functions, multiple target genes of serine/arginine-rich splicing factor 3 suggest that caffeine can regulate epithelial-mesenchymal-transition and hypoxic conditions to inhibit the survival of tumor cells.	Caffeine	117-125	serine and arginine rich splicing factor 3	Homo sapiens	65-103
24333670-9	2014	In summary, our data provide a new pathway of caffeine-modulated tumor suppression via the alternative splicing of the target genes of serine/arginine-rich splicing factor 3.	Caffeine	46-54	serine and arginine rich splicing factor 3	Homo sapiens	135-173
24361398-7	2014	Prior treatment with alpha-MSH, or RO27-3225 potentiated the caffeine-induced anxiety-like behavior.	Caffeine	61-69	pro-opiomelanocortin-alpha	Mus musculus	21-30
24361398-10	2014	Concurrent administration of alpha-MSH, or RO27-3225 with chronic caffeine delayed the development of tolerance and prevented withdrawal-induced anxiety-like behavior.	Caffeine	66-74	pro-opiomelanocortin-alpha	Mus musculus	29-38
24361398-12	2014	SIGNIFICANCE: alpha-MSH, possibly via MC4 receptor in the neuroanatomical framework of the CeA, may contribute to the acute, chronic and withdrawal actions of caffeine associated with anxiety-like behavior in the neuroanatomical framework of the CeA.	Caffeine	159-167	pro-opiomelanocortin-alpha	Mus musculus	14-23
24361398-2	2014	MAIN METHODS: Caffeine was injected intraperitoneally, alone or in combination with alpha-melanocyte stimulating hormone (alpha-MSH), the MC4 receptor agonist RO27-3225 or the antagonist HS014 via the intra-CeA route.	Caffeine	14-22	pro-opiomelanocortin-alpha	Mus musculus	122-131
24361398-12	2014	SIGNIFICANCE: alpha-MSH, possibly via MC4 receptor in the neuroanatomical framework of the CeA, may contribute to the acute, chronic and withdrawal actions of caffeine associated with anxiety-like behavior in the neuroanatomical framework of the CeA.	Caffeine	159-167	carcinoembryonic antigen gene family	Mus musculus	91-94
24361398-12	2014	SIGNIFICANCE: alpha-MSH, possibly via MC4 receptor in the neuroanatomical framework of the CeA, may contribute to the acute, chronic and withdrawal actions of caffeine associated with anxiety-like behavior in the neuroanatomical framework of the CeA.	Caffeine	159-167	carcinoembryonic antigen gene family	Mus musculus	246-249
24361398-2	2014	MAIN METHODS: Caffeine was injected intraperitoneally, alone or in combination with alpha-melanocyte stimulating hormone (alpha-MSH), the MC4 receptor agonist RO27-3225 or the antagonist HS014 via the intra-CeA route.	Caffeine	14-22	carcinoembryonic antigen gene family	Mus musculus	207-210
24465600-7	2014	Pure caffeine and the 5-hour Energy drink, on the other hand, decreased FGF19 mRNA.	Caffeine	5-13	fibroblast growth factor 19	Homo sapiens	72-77
24475304-4	2014	Pregnant A1AR knockout mice were treated with caffeine (20 mg/kg) or vehicle (0.09% NaCl) i.p.	Caffeine	46-54	adenosine A1 receptor	Mus musculus	9-13
24475304-8	2014	A1AR+/+ offspring treated in utero with caffeine were 10% heavier than vehicle controls.	Caffeine	40-48	adenosine A1 receptor	Mus musculus	0-4
24475304-11	2014	Using DNA methylation arrays, we identified altered DNA methylation patterns in A1AR+/+ caffeine treated hearts, including 7719 differentially methylated regions (DMRs) within the genome and an overall decrease in DNA methylation of 26%.	Caffeine	88-96	adenosine A1 receptor	Mus musculus	80-84
25482947-6	2014	We found that inhibitors of the mTOR pathway including rapamycin, wortmannin, and caffeine blunted the p53 response to nucleolar stress induced by actinomycin D.	Caffeine	82-90	mechanistic target of rapamycin kinase	Homo sapiens	32-36
25096793-1	2014	BACKGROUND: Phenotyping, using caffeine as probe substrate, is a proper method to assess CYP1A2 activity.	Caffeine	31-39	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	89-95
24293369-1	2014	The A2A adenosine receptor (A2AR) is a G protein-coupled receptor and a major target of caffeine.	Caffeine	88-96	adenosine A2a receptor	Rattus norvegicus	4-26
24293369-1	2014	The A2A adenosine receptor (A2AR) is a G protein-coupled receptor and a major target of caffeine.	Caffeine	88-96	adenosine A2a receptor	Rattus norvegicus	28-32
24403155-6	2014	Moreover, caffeine and modafinil affected wakefulness-induced changes in functional bands (delta, sigma, beta) of rhythmic brain activity in wakefulness and sleep in a DAT1 genotype-dependent manner.	Caffeine	10-18	solute carrier family 6 member 3	Homo sapiens	168-172
24163141-0	2014	Amplification of steroid-mediated SP-B expression by physiological levels of caffeine.	Caffeine	77-85	surfactant protein B	Homo sapiens	34-38
24163141-2	2014	The objective of this study was to identify effects of physiological levels of caffeine on glucocorticoid-mediated SP-B expression in vitro and in vivo.	Caffeine	79-87	surfactant protein B	Homo sapiens	115-119
24163141-4	2014	In vivo, SP-B expression was analyzed in bronchoalveolar lavage (BAL) of preterm sheep exposed to antenatal DEX and/or postnatal caffeine.	Caffeine	129-137	pulmonary surfactant-associated protein B	Ovis aries	9-13
24163141-5	2014	If DEX and caffeine were continuously present, SP-B mRNA and protein levels were increased for up to 6 days after induction (P &lt; 0.05).	Caffeine	11-19	surfactant protein B	Homo sapiens	47-51
24163141-6	2014	Additionally, caffeine enhanced SP-B mRNA expression in DEX-pretreated cells (P &lt; 0.05).	Caffeine	14-22	surfactant protein B	Homo sapiens	32-36
24163141-7	2014	Moreover, caffeine amplified DEX-induced pepsinogen C mRNA expression (P &lt; 0.05).	Caffeine	10-18	progastricsin	Homo sapiens	41-53
24163141-8	2014	After short-term treatment with caffeine in vivo, only slightly higher SP-B levels could be detected in BAL of preterm sheep following antenatal DEX, combined with an increase of arterial oxygen partial pressure (P &lt; 0.01).	Caffeine	32-40	pulmonary surfactant-associated protein B	Ovis aries	71-75
24163141-9	2014	Our data demonstrated that the continuous presence of caffeine in vitro is able to amplify DEX-mediated SP-B expression.	Caffeine	54-62	surfactant protein B	Homo sapiens	104-108
24163141-11	2014	An impact of caffeine on release of surfactant reservoirs from lamellar bodies could, however, quickly affect SP-B content in BAL, which has to be further investigated.	Caffeine	13-21	surfactant protein B	Homo sapiens	110-114
24423593-2	2014	P-gp (fexofenadine) and CYP-specific substrates (caffeine for CYP1A2, bupropion for CYP2B6, flurbiprofen for CYP2C9, omeprazole for CYP2C19, dextromethorphan for CYP2D6 and midazolam for CYP3A4) and their metabolites were extracted from DBS (10 microl) using methanol.	Caffeine	49-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
25025048-0	2014	Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A) gene polymorphisms.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-95
25025048-0	2014	Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A) gene polymorphisms.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
25025048-3	2014	This research aims to determine the effects of quercetin and the CYP1A2 gene polymorphisms, namely, CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A), on the metabolism of caffeine.	Caffeine	167-175	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	65-71
25025048-3	2014	This research aims to determine the effects of quercetin and the CYP1A2 gene polymorphisms, namely, CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A), on the metabolism of caffeine.	Caffeine	167-175	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
25482947-6	2014	We found that inhibitors of the mTOR pathway including rapamycin, wortmannin, and caffeine blunted the p53 response to nucleolar stress induced by actinomycin D.	Caffeine	82-90	tumor protein p53	Homo sapiens	103-106
25024327-3	2014	THC was also tested for synergy with caffeine, in respect to the reduction of the Abeta level in N2a/AbetaPPswe cells.	Caffeine	37-45	amyloid beta (A4) precursor protein	Mus musculus	82-87
23824258-2	2014	The purpose of this study was to investigate the association between caffeine intake and incidence of basal cell (BCC) and squamous cell carcinoma (SCC).	Caffeine	69-77	serpin family B member 3	Homo sapiens	148-151
25011614-0	2014	Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway.	Caffeine	0-8	protein tyrosine kinase 2	Homo sapiens	61-64
25011614-5	2014	RESULTS: Caffeine decreased the migration of rat C6 and human U87MG glioma cells and down-regulated the expression of phosphorylated focal adhesion kinase (p-FAK) and p-paxillin.	Caffeine	9-17	protein tyrosine kinase 2	Homo sapiens	158-161
25011614-6	2014	Caffeine also decreased p-FAK staining at the edge of glioma cells and disassembled actin stress fibers.	Caffeine	0-8	protein tyrosine kinase 2	Homo sapiens	26-29
25011614-8	2014	Y27632 also inhibited the caffeine-reduced expression of p-FAK and p-paxillin as well as cell migration.	Caffeine	26-34	protein tyrosine kinase 2	Homo sapiens	59-62
25175968-2	2014	The A1 and A2A adenosine receptors (A1R and A2AR) are major targets of caffeine and have been extensively investigated.	Caffeine	71-79	adenosine A2a receptor	Homo sapiens	44-48
25175972-9	2014	Activation of A2AR by its agonist infused into the brain potently increases sleep and the arousal effect of caffeine, an A1R and A2AR antagonist, was shown to be dependent on the A2AR.	Caffeine	108-116	adenosine A2a receptor	Homo sapiens	14-18
25175972-9	2014	Activation of A2AR by its agonist infused into the brain potently increases sleep and the arousal effect of caffeine, an A1R and A2AR antagonist, was shown to be dependent on the A2AR.	Caffeine	108-116	adenosine A2a receptor	Homo sapiens	129-133
25175972-9	2014	Activation of A2AR by its agonist infused into the brain potently increases sleep and the arousal effect of caffeine, an A1R and A2AR antagonist, was shown to be dependent on the A2AR.	Caffeine	108-116	adenosine A2a receptor	Homo sapiens	129-133
24173825-5	2014	Pretreatment of CRC cells with caffeine significantly inhibited paclitaxel-induced cytotoxicity by increasing the levels of the antiapoptotic Bcl-2 family member, Mcl-1.	Caffeine	31-39	BCL2 apoptosis regulator	Homo sapiens	142-147
24451874-7	2014	The femurs of the OVX and OVX/caffeine groups presented lower TBAs and higher RANKL/OPG+ cell ratios.	Caffeine	30-38	TNF superfamily member 11	Rattus norvegicus	78-83
24451874-7	2014	The femurs of the OVX and OVX/caffeine groups presented lower TBAs and higher RANKL/OPG+ cell ratios.	Caffeine	30-38	TNF receptor superfamily member 11B	Rattus norvegicus	84-87
24451874-8	2014	The number of TRAP+ cells was higher in femurs of the caffeine group and in defects of the OVX group.	Caffeine	54-62	acid phosphatase 5, tartrate resistant	Rattus norvegicus	14-18
24451874-9	2014	The caffeine/OVX group presented the highest RANKL/OPG+ cell ratio in femurs and defects.	Caffeine	4-12	TNF superfamily member 11	Rattus norvegicus	45-50
24451874-9	2014	The caffeine/OVX group presented the highest RANKL/OPG+ cell ratio in femurs and defects.	Caffeine	4-12	TNF receptor superfamily member 11B	Rattus norvegicus	51-54
24173825-0	2014	Caffeine inhibits paclitaxel-induced apoptosis in colorectal cancer cells through the upregulation of Mcl-1 levels.	Caffeine	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	102-107
24173825-5	2014	Pretreatment of CRC cells with caffeine significantly inhibited paclitaxel-induced cytotoxicity by increasing the levels of the antiapoptotic Bcl-2 family member, Mcl-1.	Caffeine	31-39	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	163-168
24173825-8	2014	Moreover, administration of caffeine may decrease chemotherapeutic responses to paclitaxel by the MEK-ERK mediated upregulation of Mcl-1.	Caffeine	28-36	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101
24173825-8	2014	Moreover, administration of caffeine may decrease chemotherapeutic responses to paclitaxel by the MEK-ERK mediated upregulation of Mcl-1.	Caffeine	28-36	mitogen-activated protein kinase 1	Homo sapiens	102-105
24173825-8	2014	Moreover, administration of caffeine may decrease chemotherapeutic responses to paclitaxel by the MEK-ERK mediated upregulation of Mcl-1.	Caffeine	28-36	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	131-136
24056197-3	2013	The present studies address the ability of the psychostimulant drugs, methamphetamine (MA), modafinil (MOD) or caffeine (CAF), to modify the light-induced responses.	Caffeine	111-119	caffeine susceptibility	Mus musculus	121-124
25011471-3	2014	METHODS: Caffeine was given orally (10 mg/kg/day) from postnatal day (p)1 to p14 to pups exposed to intra-amniotic LPS or normal saline.	Caffeine	9-17	S100 calcium binding protein A9	Rattus norvegicus	77-80
24738643-3	2014	The ratio of phospharylated eIF-2alpha to dephospharylated eIF-2alpha increased, whereas cyclin D1 decreased significantly under combined treatment of tetrandrine (5 muM) and caffeine (1 mM).	Caffeine	175-183	eukaryotic translation initiation factor 2A	Homo sapiens	59-69
24738643-3	2014	The ratio of phospharylated eIF-2alpha to dephospharylated eIF-2alpha increased, whereas cyclin D1 decreased significantly under combined treatment of tetrandrine (5 muM) and caffeine (1 mM).	Caffeine	175-183	cyclin D1	Homo sapiens	89-98
24738643-4	2014	The cleaved PARP-1 to PARP-1 ratio was elevated significantly under treatment of 5 muM tetrandrine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	154-162	poly(ADP-ribose) polymerase 1	Homo sapiens	12-18
24738643-4	2014	The cleaved PARP-1 to PARP-1 ratio was elevated significantly under treatment of 5 muM tetrandrine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	154-162	poly(ADP-ribose) polymerase 1	Homo sapiens	22-28
24738643-4	2014	The cleaved PARP-1 to PARP-1 ratio was elevated significantly under treatment of 5 muM tetrandrine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	154-162	latexin	Homo sapiens	134-137
24738643-5	2014	The expression levels of AIF increased significantly under treatment of 5 muM tetrandrine alone or 1 mM caffeine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	104-112	apoptosis inducing factor mitochondria associated 1	Homo sapiens	25-28
24738643-5	2014	The expression levels of AIF increased significantly under treatment of 5 muM tetrandrine alone or 1 mM caffeine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	168-176	apoptosis inducing factor mitochondria associated 1	Homo sapiens	25-28
24738643-5	2014	The expression levels of AIF increased significantly under treatment of 5 muM tetrandrine alone or 1 mM caffeine alone, and combined treatment of 5 muM tetrandrine and caffeine (0.5, 1 mM).	Caffeine	168-176	latexin	Homo sapiens	148-151
24738643-6	2014	In conclusion, tetrandrine and caffeine could induce glioma cell death possibly via increasing eIF-2alpha phospharylation, decreasing cyclin-D1 expression, and increasing caspase-dependent and -independent apoptosis pathways.	Caffeine	31-39	eukaryotic translation initiation factor 2A	Homo sapiens	95-105
24738643-6	2014	In conclusion, tetrandrine and caffeine could induce glioma cell death possibly via increasing eIF-2alpha phospharylation, decreasing cyclin-D1 expression, and increasing caspase-dependent and -independent apoptosis pathways.	Caffeine	31-39	cyclin D1	Homo sapiens	134-143
24950113-4	2014	Caffeine increased (p &lt; 0.05) pre-exercise DBP and MAP.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	46-49
24950113-5	2014	In caffeine and placebo conditions significant decreases (p &lt; 0.05) were noted in SBP, MAP, and PVR between the pre- and post-exercise time points.	Caffeine	3-11	selenium binding protein 1	Homo sapiens	85-88
24950113-6	2014	Notwithstanding, the mean values for SBP, DBP and MAP during the 9 h of post-exercise monitoring were increased (p &lt; 0.05) for the caffeine.	Caffeine	134-142	selenium binding protein 1	Homo sapiens	37-40
24950113-6	2014	Notwithstanding, the mean values for SBP, DBP and MAP during the 9 h of post-exercise monitoring were increased (p &lt; 0.05) for the caffeine.	Caffeine	134-142	D-box binding PAR bZIP transcription factor	Homo sapiens	42-45
23808892-7	2013	Caffeine also inhibited procollagen type Ic and alpha-SMA expression in a dose- and time-dependent manner.	Caffeine	0-8	actin gamma 2, smooth muscle	Rattus norvegicus	48-57
24349501-0	2013	Effect of caffeine-containing beverage consumption on serum alanine aminotransferase levels in patients with chronic hepatitis C virus infection: a hospital-based cohort study.	Caffeine	10-18	glutamic--pyruvic transaminase	Homo sapiens	60-84
24379627-0	2013	Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine.	Caffeine	69-77	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
24196726-3	2013	Increasingly being sold as a dietary supplement, many people, particularly those in the health and fitness community, where it is touted as a fitness and muscle building aid, are consuming caffeine anhydrous on a daily basis.	Caffeine	189-197	activation induced cytidine deaminase	Homo sapiens	170-173
23808892-9	2013	Transforming growth factor-beta and alpha-SMA expressions were also reduced by caffeine.	Caffeine	79-87	actin gamma 2, smooth muscle	Rattus norvegicus	36-45
23504818-9	2013	Stress interacted with caffeine and sex to alter cortisol, fibrinogen and systolic BP but not CRP levels.	Caffeine	23-31	fibrinogen beta chain	Homo sapiens	59-69
24761282-3	2013	It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia.	Caffeine	34-42	tumor necrosis factor	Homo sapiens	101-110
24761282-3	2013	It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia.	Caffeine	34-42	tumor necrosis factor	Homo sapiens	112-139
24761282-3	2013	It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-alpha (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia.	Caffeine	220-228	tumor necrosis factor	Homo sapiens	101-110
23679834-0	2013	Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.	Caffeine	48-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	13-32
23679834-1	2013	Caffeine (1,3,7-trimethylxanthine) is a phenotyping substrate for human cytochrome P450 1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-91
23679834-1	2013	Caffeine (1,3,7-trimethylxanthine) is a phenotyping substrate for human cytochrome P450 1A2.	Caffeine	10-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-91
24245751-4	2013	In particular, caffeine could be measured at a 25 muM detection limit.	Caffeine	15-23	latexin	Homo sapiens	50-53
23709289-0	2013	The effects of caffeine ingestion before passive heat loading on serum leptin levels in humans.	Caffeine	15-23	leptin	Homo sapiens	71-77
23709289-1	2013	We assessed the effects of ingesting caffeine before passive heat loading (PHL) on serum leptin and sweating response, which are both physiological responses associated with energy expenditure.	Caffeine	37-45	leptin	Homo sapiens	89-95
23255408-8	2013	Nevertheless, caffeine at 5 and 10 mm dramatically decreased the viability and ALP activity of the cells after 4 days such that, by day 9, the viability of cells declined to near zero in the 10 mm group.	Caffeine	14-22	alkaline phosphatase, placental	Homo sapiens	79-82
23996078-0	2013	A pharmacometric approach to investigate the impact of methylxanthine abstinence and caffeine consumption on CYP1A2 activity.	Caffeine	85-93	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
23996078-1	2013	This study aimed to investigate the impact of methylxanthine abstinence (MA) periods on CYP1A2 activity in individuals with varying levels of caffeine consumption through development of a population pharmacokinetic model of caffeine and its major metabolite paraxanthine.	Caffeine	142-150	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94
23996078-1	2013	This study aimed to investigate the impact of methylxanthine abstinence (MA) periods on CYP1A2 activity in individuals with varying levels of caffeine consumption through development of a population pharmacokinetic model of caffeine and its major metabolite paraxanthine.	Caffeine	224-232	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94
22886764-10	2013	Quantitative RT-PCR showed significant up-regulation after caffeine exposure in HSP70 at 72 hpf; in Cyclin G1 at 24, 48 and 72 hpf; and in Bax at 48 and 72 hpf.	Caffeine	59-67	heat shock protein 8-like	Danio rerio	80-85
22886764-10	2013	Quantitative RT-PCR showed significant up-regulation after caffeine exposure in HSP70 at 72 hpf; in Cyclin G1 at 24, 48 and 72 hpf; and in Bax at 48 and 72 hpf.	Caffeine	59-67	cyclin G1	Danio rerio	100-109
22886764-10	2013	Quantitative RT-PCR showed significant up-regulation after caffeine exposure in HSP70 at 72 hpf; in Cyclin G1 at 24, 48 and 72 hpf; and in Bax at 48 and 72 hpf.	Caffeine	59-67	BCL2 associated X, apoptosis regulator a	Danio rerio	139-142
23255408-0	2013	Caffeine alters mitochondrial dehydrogenase and alkaline phosphatase activity of human gingival fibroblasts in vitro.	Caffeine	0-8	alkaline phosphatase, placental	Homo sapiens	48-68
23255408-9	2013	CONCLUSION: These results provided evidence that caffeine in high concentrations can decrease cellular viability and ALP activity in HGF.	Caffeine	49-57	alkaline phosphatase, placental	Homo sapiens	117-120
23255408-3	2013	In this study we analyzed the viability of human gingival fibroblasts (HGF) and alkaline phosphatase (ALP) enzyme activity after exposure to different concentrations of caffeine for different exposure time periods.	Caffeine	169-177	alkaline phosphatase, placental	Homo sapiens	80-100
23255408-3	2013	In this study we analyzed the viability of human gingival fibroblasts (HGF) and alkaline phosphatase (ALP) enzyme activity after exposure to different concentrations of caffeine for different exposure time periods.	Caffeine	169-177	alkaline phosphatase, placental	Homo sapiens	102-105
23255408-9	2013	CONCLUSION: These results provided evidence that caffeine in high concentrations can decrease cellular viability and ALP activity in HGF.	Caffeine	49-57	hepatocyte growth factor	Homo sapiens	133-136
23255408-4	2013	METHODS: The HGF were cultured with different concentrations of caffeine.	Caffeine	64-72	hepatocyte growth factor	Homo sapiens	13-16
23255408-6	2013	The activity of ALP was analyzed at specific time intervals after caffeine addition.	Caffeine	66-74	alkaline phosphatase, placental	Homo sapiens	16-19
23921184-3	2013	Caffeine, a nonselective competitive PDE inhibitor, due to its structural similarity to adenosine molecule maintains the cAMP level by occupying PDE enzymes such as PDE-3A inside the oocyte and PDE-4 and PDE-5 in the cumulus cells.	Caffeine	0-8	phosphodiesterase 3A	Canis lupus familiaris	165-171
23886299-9	2013	Direct exposure of the epitrochlearis muscle to 0.5mmol/L AICAR or 1mmol/L caffeine, which activated p-AMPK increased both MCT1 and MCT4 mRNA levels.	Caffeine	75-83	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	101-107
23886299-9	2013	Direct exposure of the epitrochlearis muscle to 0.5mmol/L AICAR or 1mmol/L caffeine, which activated p-AMPK increased both MCT1 and MCT4 mRNA levels.	Caffeine	75-83	solute carrier family 16 member 1	Rattus norvegicus	123-127
23886299-9	2013	Direct exposure of the epitrochlearis muscle to 0.5mmol/L AICAR or 1mmol/L caffeine, which activated p-AMPK increased both MCT1 and MCT4 mRNA levels.	Caffeine	75-83	solute carrier family 16 member 3	Rattus norvegicus	132-136
23831977-1	2013	Vibrational spectra and molecular structure of anhydrous caffeine have been systematically investigated by second order Moller-Plesset (MP2) perturbation theory and density functional theory (DFT) calculations.	Caffeine	57-65	tryptase pseudogene 1	Homo sapiens	136-139
23831979-0	2013	Investigation of the binding sites and orientation of caffeine on human serum albumin by surface-enhanced Raman scattering and molecular docking.	Caffeine	54-62	albumin	Homo sapiens	72-85
23831979-1	2013	Fluorescence, normal Raman and surface-enhanced Raman scattering (SERS) were introduced to explore the absorptive geometry of caffeine on Human Serum Albumin (HSA) at physiological condition.	Caffeine	126-134	albumin	Homo sapiens	144-157
23921184-3	2013	Caffeine, a nonselective competitive PDE inhibitor, due to its structural similarity to adenosine molecule maintains the cAMP level by occupying PDE enzymes such as PDE-3A inside the oocyte and PDE-4 and PDE-5 in the cumulus cells.	Caffeine	0-8	phosphodiesterase 5A	Canis lupus familiaris	204-209
23921184-6	2013	Caffeine pretreatment induced higher mitogen-activated protein kinases (MAPK1 and MAPK3) phosphorylation and maturation-promoting factor activity at 12 hours and activated MAPK1 and maturation-promoting factor at 48 hours after culture in cumulus-oocyte complexes (COCs) compared with the control group (P &lt; 0.05).	Caffeine	0-8	mitogen-activated protein kinase 1	Canis lupus familiaris	72-77
23921184-6	2013	Caffeine pretreatment induced higher mitogen-activated protein kinases (MAPK1 and MAPK3) phosphorylation and maturation-promoting factor activity at 12 hours and activated MAPK1 and maturation-promoting factor at 48 hours after culture in cumulus-oocyte complexes (COCs) compared with the control group (P &lt; 0.05).	Caffeine	0-8	mitogen-activated protein kinase 3	Canis lupus familiaris	82-87
23921184-6	2013	Caffeine pretreatment induced higher mitogen-activated protein kinases (MAPK1 and MAPK3) phosphorylation and maturation-promoting factor activity at 12 hours and activated MAPK1 and maturation-promoting factor at 48 hours after culture in cumulus-oocyte complexes (COCs) compared with the control group (P &lt; 0.05).	Caffeine	0-8	mitogen-activated protein kinase 1	Canis lupus familiaris	172-177
23515941-6	2013	Inhibition of ATM by the pharmacological inhibitor caffeine or siRNA effectively prevented the activation of ATM-dependent pathways and rescued the G2 arrest elicited by OTA.	Caffeine	51-59	ATM serine/threonine kinase	Homo sapiens	14-17
22976123-0	2013	Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity.	Caffeine	8-16	solute carrier family 2 member 4	Rattus norvegicus	102-107
22976123-0	2013	Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity.	Caffeine	8-16	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	125-129
22976123-11	2013	Caffeine neither modified skeletal muscle AMPK expression nor activity in aged rats; however, it decreased visceral and total fat in 12 M rats and it restored skeletal muscle Glut4 expression to control values in 24 M rats.	Caffeine	0-8	solute carrier family 2 member 4	Rattus norvegicus	175-180
22976123-12	2013	We concluded that chronic caffeine intake reverses aging-induced insulin resistance in rats by decreasing NEFA production and also by increasing Glut4 expression in skeletal muscle.	Caffeine	26-34	solute carrier family 2 member 4	Rattus norvegicus	145-150
23870730-0	2013	Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells.	Caffeine	0-8	cystatin SN	Homo sapiens	37-48
23515941-6	2013	Inhibition of ATM by the pharmacological inhibitor caffeine or siRNA effectively prevented the activation of ATM-dependent pathways and rescued the G2 arrest elicited by OTA.	Caffeine	51-59	ATM serine/threonine kinase	Homo sapiens	109-112
23870730-1	2013	OBJECTIVE: The study aimed at evaluating in vitro the effect of caffeine on expression of cystatin SN, a potential marker of sensitivity to bitterness in humans.	Caffeine	64-72	cystatin SN	Homo sapiens	90-101
23920241-9	2013	Caffeine treatment during SD, significantly increased early proliferative and post-mitotic stages of doublecortin (DCX) positive cells while modafinil treatment during SD, increased intermediate and post-mitotic stages of DCX positive cells compared to SD+Vehicle group.	Caffeine	0-8	doublecortin	Rattus norvegicus	115-118
23870730-4	2013	Finally, effects of 5, 50 and 100muM caffeine exposure on cystatin SN expression were explored over 3 days by ELISA.	Caffeine	37-45	cystatin SN	Homo sapiens	58-69
23870730-7	2013	There was a significant (p&lt;0.001) effect of caffeine on cystatin SN expression specifically in differentiated cells.	Caffeine	47-55	cystatin SN	Homo sapiens	59-70
23870730-9	2013	The results suggest that salivary cystatin SN abundance may depend on caffeine intake, with possible consequences on taste sensitivity.	Caffeine	70-78	cystatin SN	Homo sapiens	34-45
23920241-9	2013	Caffeine treatment during SD, significantly increased early proliferative and post-mitotic stages of doublecortin (DCX) positive cells while modafinil treatment during SD, increased intermediate and post-mitotic stages of DCX positive cells compared to SD+Vehicle group.	Caffeine	0-8	doublecortin	Rattus norvegicus	222-225
23920241-11	2013	Both caffeine and modafinil significantly improved BDNF expression in the DG region.	Caffeine	5-13	brain-derived neurotrophic factor	Rattus norvegicus	51-55
23920241-14	2013	Caffeine and modafinil induced alterations of NCP during SD may involve modulation of BDNF and adenosine levels.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	86-90
23871419-5	2013	Both caffeine and theophylline induced apoptosis, and the treated cells expressed annexin V and caspase 3/7.	Caffeine	5-13	caspase 3	Canis lupus familiaris	96-105
23682612-5	2013	In this study, we investigated the effects of methanol, ethanol, acetonitrile and dimethyl sulfoxide (1% to 4%) on the assessment of km, Vmax and Clint for the metabolism of midazolam via CYP3A4 to 1-hydroxymidazolam and the metabolism of caffeine to paraxanthine via CYP1A2 using expressed enzymes in vitro.	Caffeine	239-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	188-194
23804200-5	2013	The tBK current was inhibited by caffeine (10 mM), ryanodine (30 muM), and tetracaine (100 muM), suggesting that RyR-mediated Ca(2+) release contributed to the activation of the tBK current.	Caffeine	33-41	LOC100009439	Oryctolagus cuniculus	113-116
23941746-6	2013	HBP/SLBP mRNA alternative splicing returned to low levels again upon removal of replication stress and was abrogated by caffeine, suggesting the involvement of checkpoint kinases.	Caffeine	120-128	stem-loop binding protein	Homo sapiens	0-3
23727139-0	2013	Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc).	Caffeine	42-50	glycine-N-acyltransferase	Homo sapiens	112-115
23727139-4	2013	The loading of caffeine into the poly(NIPAM-co-AAc) nanogel was found to be significantly higher at 2-4 C than at RT (p=0.0072).	Caffeine	15-23	glycine-N-acyltransferase	Homo sapiens	47-50
23727139-7	2013	In vitro diffusion studies across epidermis porcine skin were carried out at 32 C for the saturated solution of caffeine as well as caffeine-loaded poly(NIPAM-co-AAc) and polyNIPAM nanogels.	Caffeine	132-140	glycine-N-acyltransferase	Homo sapiens	162-165
23727139-8	2013	The in vitro permeation data of caffeine-loaded poly(NIPAM-co-AAc) at 2-4 C were shown to enhance the delivery of the loaded caffeine across the epidermis in comparison to the saturated solution of caffeine, by 3.5 orders of magnitude.	Caffeine	32-40	glycine-N-acyltransferase	Homo sapiens	62-65
23727139-8	2013	The in vitro permeation data of caffeine-loaded poly(NIPAM-co-AAc) at 2-4 C were shown to enhance the delivery of the loaded caffeine across the epidermis in comparison to the saturated solution of caffeine, by 3.5 orders of magnitude.	Caffeine	125-133	glycine-N-acyltransferase	Homo sapiens	62-65
23727139-8	2013	The in vitro permeation data of caffeine-loaded poly(NIPAM-co-AAc) at 2-4 C were shown to enhance the delivery of the loaded caffeine across the epidermis in comparison to the saturated solution of caffeine, by 3.5 orders of magnitude.	Caffeine	125-133	glycine-N-acyltransferase	Homo sapiens	62-65
23941746-6	2013	HBP/SLBP mRNA alternative splicing returned to low levels again upon removal of replication stress and was abrogated by caffeine, suggesting the involvement of checkpoint kinases.	Caffeine	120-128	stem-loop binding protein	Homo sapiens	4-8
23707387-3	2013	Caffeine treatment elicited MKP-1 down-regulation and PP2Acalpha up-regulation.	Caffeine	0-8	dual specificity phosphatase 1	Homo sapiens	28-33
23707387-1	2013	This study explores the signaling transduction cascade of ERK and p38 MAPK on regulating MAPK phosphatase-1 (MKP-1) and protein phosphatase 2A catalytic subunit alpha (PP2Acalpha) expression in caffeine-treated human leukemia U937 cells.	Caffeine	194-202	mitogen-activated protein kinase 1	Homo sapiens	58-61
23707387-4	2013	The transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) abolished the caffeine effect on MKP-1 and PP2Acalpha expression.	Caffeine	112-120	mitogen-activated protein kinase kinase 1	Homo sapiens	42-46
23707387-1	2013	This study explores the signaling transduction cascade of ERK and p38 MAPK on regulating MAPK phosphatase-1 (MKP-1) and protein phosphatase 2A catalytic subunit alpha (PP2Acalpha) expression in caffeine-treated human leukemia U937 cells.	Caffeine	194-202	mitogen-activated protein kinase 14	Homo sapiens	66-69
23723061-10	2013	In WT atria, reduction in INa could be produced by treatment with high extracellular Ca(2+), caffeine, or cyclopiazonic acid, each expected to produce an acute increase in [Ca(2+)]i.	Caffeine	93-101	internexin neuronal intermediate filament protein, alpha	Mus musculus	26-29
23707387-1	2013	This study explores the signaling transduction cascade of ERK and p38 MAPK on regulating MAPK phosphatase-1 (MKP-1) and protein phosphatase 2A catalytic subunit alpha (PP2Acalpha) expression in caffeine-treated human leukemia U937 cells.	Caffeine	194-202	dual specificity phosphatase 1	Homo sapiens	89-107
23707387-1	2013	This study explores the signaling transduction cascade of ERK and p38 MAPK on regulating MAPK phosphatase-1 (MKP-1) and protein phosphatase 2A catalytic subunit alpha (PP2Acalpha) expression in caffeine-treated human leukemia U937 cells.	Caffeine	194-202	dual specificity phosphatase 1	Homo sapiens	109-114
23707387-2	2013	Caffeine induced an increase in the intracellular Ca(2+) concentration and ROS generation leading to p38 MAPK activation and ERK inactivation, respectively.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	101-104
23707387-2	2013	Caffeine induced an increase in the intracellular Ca(2+) concentration and ROS generation leading to p38 MAPK activation and ERK inactivation, respectively.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	125-128
25949143-9	2013	Caffeine suppressed the expression of Mfap5 but the effect of DPHC was different by the concentration.	Caffeine	0-8	microfibrillar associated protein 5	Mus musculus	38-43
25949143-11	2013	Based on this study, we revealed firstly the effects of caffeine and DPHC on the expression of collagens, elastin, and glycoproteins during adipogenesis of msADSCs.	Caffeine	56-64	elastin	Mus musculus	106-113
23707387-4	2013	The transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) abolished the caffeine effect on MKP-1 and PP2Acalpha expression.	Caffeine	112-120	mitogen-activated protein kinase 14	Homo sapiens	78-81
23707387-4	2013	The transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) abolished the caffeine effect on MKP-1 and PP2Acalpha expression.	Caffeine	112-120	dual specificity phosphatase 1	Homo sapiens	131-136
23707387-5	2013	Caffeine repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated CREB phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	19-22
23707387-5	2013	Caffeine repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated CREB phosphorylation.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37
23707387-5	2013	Caffeine repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated CREB phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	65-68
23707387-5	2013	Caffeine repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated CREB phosphorylation.	Caffeine	0-8	cAMP responsive element binding protein 1	Homo sapiens	83-87
23707387-8	2013	Moreover, transfection of dominant negative MKP-1 cDNA led to p38 MAPK activation and PP2Acalpha down-regulation in U937 cells, while PP2A inhibitor attenuated caffeine-induced ERK inactivation and MKP-1 down-regulation.	Caffeine	160-168	dual specificity phosphatase 1	Homo sapiens	44-49
23707387-8	2013	Moreover, transfection of dominant negative MKP-1 cDNA led to p38 MAPK activation and PP2Acalpha down-regulation in U937 cells, while PP2A inhibitor attenuated caffeine-induced ERK inactivation and MKP-1 down-regulation.	Caffeine	160-168	mitogen-activated protein kinase 1	Homo sapiens	177-180
23707387-8	2013	Moreover, transfection of dominant negative MKP-1 cDNA led to p38 MAPK activation and PP2Acalpha down-regulation in U937 cells, while PP2A inhibitor attenuated caffeine-induced ERK inactivation and MKP-1 down-regulation.	Caffeine	160-168	dual specificity phosphatase 1	Homo sapiens	198-203
23912595-5	2013	Interestingly, caffeine, the most commonly used psychoactive substance, is known to inhibit both the A1R and A2AR.	Caffeine	15-23	adenosine A2a receptor	Mus musculus	109-113
23900282-0	2013	Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer"s disease.	Caffeine	8-16	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	91-95
23926202-6	2013	These results demonstrate that exposure to A2AR antagonists including caffeine during pregnancy and lactation in rodents may have adverse effects on the neural development of their offspring.	Caffeine	70-78	adenosine A2a receptor	Mus musculus	43-47
23900282-0	2013	Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer"s disease.	Caffeine	8-16	presenilin 1	Mus musculus	103-106
23900282-4	2013	The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect.	Caffeine	66-74	brain derived neurotrophic factor	Mus musculus	151-155
23900282-4	2013	The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect.	Caffeine	66-74	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	160-164
23900282-4	2013	The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect.	Caffeine	66-74	presenilin 1	Mus musculus	168-171
23900282-5	2013	The results suggested that chronic caffeine treatment may reverse memory impairment in PS1/APP transgenic mice, and BDNF and its receptor TrkB, may be involved in this process.	Caffeine	35-43	presenilin 1	Mus musculus	87-90
23727198-7	2013	Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein-alpha, adipocyte lipid binding protein, lipoprotein lipase, leptin, and TNFalpha in a dose-dependent manner.	Caffeine	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	74-122
23727198-7	2013	Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein-alpha, adipocyte lipid binding protein, lipoprotein lipase, leptin, and TNFalpha in a dose-dependent manner.	Caffeine	0-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	124-160
23727198-7	2013	Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein-alpha, adipocyte lipid binding protein, lipoprotein lipase, leptin, and TNFalpha in a dose-dependent manner.	Caffeine	0-8	fatty acid binding protein 4, adipocyte	Mus musculus	162-193
23727198-7	2013	Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein-alpha, adipocyte lipid binding protein, lipoprotein lipase, leptin, and TNFalpha in a dose-dependent manner.	Caffeine	0-8	lipoprotein lipase	Mus musculus	195-213
23727198-7	2013	Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein-alpha, adipocyte lipid binding protein, lipoprotein lipase, leptin, and TNFalpha in a dose-dependent manner.	Caffeine	0-8	tumor necrosis factor	Mus musculus	227-235
23727198-8	2013	Rather, low concentration of caffeine (0.1mM) significantly increased IL-6 expression, but unexpectedly inhibited that at a concentration more than 0.3mM.	Caffeine	29-37	interleukin 6	Mus musculus	70-74
23850513-1	2013	AIMS: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B.	Caffeine	6-14	monoamine oxidase A	Homo sapiens	75-106
23850513-7	2013	KEY FINDINGS: Caffeine acts as a MAO inhibitor with Ki values of 0.70 mM and 3.83 mM for the inhibition of MAO-A and MAO-B, respectively.	Caffeine	14-22	monoamine oxidase A	Homo sapiens	107-112
23850513-7	2013	KEY FINDINGS: Caffeine acts as a MAO inhibitor with Ki values of 0.70 mM and 3.83 mM for the inhibition of MAO-A and MAO-B, respectively.	Caffeine	14-22	monoamine oxidase B	Homo sapiens	117-122
23850513-9	2013	SIGNIFICANCE: Although structural modifications of caffeine lead to highly potent MAO inhibitors, caffeine is a weak inhibitor of MAO-A and MAO-B.	Caffeine	98-106	monoamine oxidase A	Homo sapiens	130-135
23850513-9	2013	SIGNIFICANCE: Although structural modifications of caffeine lead to highly potent MAO inhibitors, caffeine is a weak inhibitor of MAO-A and MAO-B.	Caffeine	98-106	monoamine oxidase B	Homo sapiens	140-145
23644096-8	2013	In the third experiment, placebo and caffeine pre-treated rats were UV-B-exposed and the presence of activated caspase-3 was visualized by immunohistochemistry.	Caffeine	37-45	caspase 3	Rattus norvegicus	111-120
23791077-1	2013	The commonly used beverage and psychostimulant caffeine is known to inhibit human acetylcholinesterase enzyme.	Caffeine	47-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-102
23791077-4	2013	In this study, we investigated the cholinesterase inhibition by the xanthine derivatives caffeine, pentoxifylline, and propentofylline.	Caffeine	89-97	butyrylcholinesterase	Homo sapiens	35-49
23791077-9	2013	Molecular modeling investigations indicate that caffeine binds primarily in the catalytic site (Ser203, Glu334 and His447) region of hAChE whereas pentoxifylline and propentofylline are able to bind to both the catalytic site and peripheral anionic site due to their increased bulk/size, thereby exhibiting superior AChE inhibition relative to caffeine.	Caffeine	48-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
23791077-9	2013	Molecular modeling investigations indicate that caffeine binds primarily in the catalytic site (Ser203, Glu334 and His447) region of hAChE whereas pentoxifylline and propentofylline are able to bind to both the catalytic site and peripheral anionic site due to their increased bulk/size, thereby exhibiting superior AChE inhibition relative to caffeine.	Caffeine	344-352	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
23791077-11	2013	In summary, our study has important implications in the development of novel caffeine derivatives as selective AChE inhibitors with potential application as cognitive enhancers and to treat various forms of dementia.	Caffeine	77-85	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
23644096-11	2013	There was more caspase-3 staining in UV-B-exposed lenses from the placebo group than in UV-B-exposed lenses from the caffeine group.	Caffeine	117-125	caspase 3	Rattus norvegicus	15-24
24734165-2	2013	Caffeine (CAF) is often administered to premature infants to stimulate respiration, and these infants are also exposed simultaneously to anesthetic drugs for procedural sedation and/or surgical procedures.	Caffeine	0-8	caffeine susceptibility	Mus musculus	10-13
23788688-0	2013	Inhibition of parathyroid hormone secretion by caffeine in human parathyroid cells.	Caffeine	47-55	parathyroid hormone	Homo sapiens	14-33
23788688-5	2013	DESIGN, SETTING, AND PATIENTS: Effects of caffeine on PTH secretion and Ca(2+) levels were determined by batch incubation and Fura-2, respectively, in pathological parathyroid cells.	Caffeine	42-50	parathyroid hormone	Homo sapiens	54-57
23788688-8	2013	RESULTS: We studied physiological concentrations of caffeine ranging from 1 to 50 mum and found that 50 mum caffeine caused a significant decrease of PTH secretion and PTH gene expression.	Caffeine	52-60	parathyroid hormone	Homo sapiens	150-153
23788688-8	2013	RESULTS: We studied physiological concentrations of caffeine ranging from 1 to 50 mum and found that 50 mum caffeine caused a significant decrease of PTH secretion and PTH gene expression.	Caffeine	52-60	parathyroid hormone	Homo sapiens	168-171
23788688-8	2013	RESULTS: We studied physiological concentrations of caffeine ranging from 1 to 50 mum and found that 50 mum caffeine caused a significant decrease of PTH secretion and PTH gene expression.	Caffeine	108-116	parathyroid hormone	Homo sapiens	150-153
23788688-8	2013	RESULTS: We studied physiological concentrations of caffeine ranging from 1 to 50 mum and found that 50 mum caffeine caused a significant decrease of PTH secretion and PTH gene expression.	Caffeine	108-116	parathyroid hormone	Homo sapiens	168-171
23788688-11	2013	Protein expressions demonstrated two main targets for caffeine-ADORA1 and ADORA2A.	Caffeine	54-62	adenosine A1 receptor	Homo sapiens	63-69
23788688-11	2013	Protein expressions demonstrated two main targets for caffeine-ADORA1 and ADORA2A.	Caffeine	54-62	glycoprotein hormone subunit alpha 2	Homo sapiens	74-81
23788688-12	2013	CONCLUSION: A physiological high dose of caffeine inhibits PTH secretion in human parathyroid cells, possibly due to a decrease of the intracellular level of cAMP.	Caffeine	41-49	parathyroid hormone	Homo sapiens	59-62
23744361-6	2013	Accordingly, when cell cycle arrest was disabled by addition of caffeine, the antitumor activity of TRAIL was reduced.	Caffeine	64-72	TNF superfamily member 10	Homo sapiens	100-105
23733185-8	2013	HNE-mediated ATR/Chk1 signaling was inhibited by ATR kinase inhibitor (caffeine).	Caffeine	71-79	ATR serine/threonine kinase	Homo sapiens	13-16
23733185-8	2013	HNE-mediated ATR/Chk1 signaling was inhibited by ATR kinase inhibitor (caffeine).	Caffeine	71-79	checkpoint kinase 1	Homo sapiens	17-21
23733185-8	2013	HNE-mediated ATR/Chk1 signaling was inhibited by ATR kinase inhibitor (caffeine).	Caffeine	71-79	ATR serine/threonine kinase	Homo sapiens	49-52
23299767-1	2013	PURPOSE: The objective of this study is as follows: 1) to determine the effects of caffeine supplementation on the inflammatory response (IL-6 and IL-10 levels and leukocyte numbers) induced by a 15-km run competition and 2) to examine the effect of caffeine supplementation on the energetic metabolites as well as on the exercise-induced oxidative stress.	Caffeine	83-91	interleukin 6	Homo sapiens	138-142
23299767-12	2013	CONCLUSION: Caffeine supplementation induced higher levels of IL-6 and IL-10 in response to exercise, enhancing the anti-inflammatory response.	Caffeine	12-20	interleukin 6	Homo sapiens	62-66
23299767-12	2013	CONCLUSION: Caffeine supplementation induced higher levels of IL-6 and IL-10 in response to exercise, enhancing the anti-inflammatory response.	Caffeine	12-20	interleukin 10	Homo sapiens	71-76
23299767-13	2013	The caffeine-induced increase in adrenaline could be responsible for the higher increase in IL-6 levels, as well as for the increased lactate levels.	Caffeine	4-12	interleukin 6	Homo sapiens	92-96
23666627-0	2013	Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation.	Caffeine	0-8	RAD51 recombinase	Mus musculus	71-76
23666627-3	2013	Biochemical and structural biology experiments revealed that caffeine interfered with a pivotal step in homologous recombination, homologous joint molecule formation, through increasing interactions of the RAD51 nucleoprotein filament with non-homologous DNA.	Caffeine	61-69	RAD51 recombinase	Mus musculus	206-211
23785666-6	2013	Caffeine administration enhances UVB-induced apoptosis by p53-dependent and p53-independent mechanisms.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	58-61
23785666-6	2013	Caffeine administration enhances UVB-induced apoptosis by p53-dependent and p53-independent mechanisms.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	76-79
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	57-65	transformation related protein 53, pseudogene	Mus musculus	19-22
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	57-65	ataxia telangiectasia and Rad3 related	Mus musculus	154-157
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	57-65	checkpoint kinase 1	Mus musculus	188-192
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	57-65	cyclin B1	Mus musculus	245-254
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	273-281	ataxia telangiectasia and Rad3 related	Mus musculus	154-157
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	103-111	ataxia telangiectasia and Rad3 related	Mus musculus	57-60
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	103-111	ataxia telangiectasia and Rad3 related	Mus musculus	95-98
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	103-111	ataxia telangiectasia and Rad3 related	Mus musculus	95-98
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	103-111	checkpoint kinase 1	Mus musculus	206-210
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	238-246	ataxia telangiectasia and Rad3 related	Mus musculus	57-60
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	238-246	ataxia telangiectasia and Rad3 related	Mus musculus	95-98
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	238-246	ataxia telangiectasia and Rad3 related	Mus musculus	95-98
23785666-10	2013	These results, which indicate that genetic inhibition of ATR (like pharmacologic inhibition of ATR via caffeine) inhibits UVB-induced carcinogenesis support the concept that ATR-mediated phosphorylation of Chk1 is an important target for caffeine"s inhibitory effect on UVB-induced carcinogenesis.	Caffeine	238-246	checkpoint kinase 1	Mus musculus	206-210
23301724-4	2013	Caffeine had biphasic effects: 0.1 mM caffeine significantly enhanced mineralization and alkaline phosphatase (ALP) activity.	Caffeine	0-8	alkaline phosphatase, placental	Homo sapiens	111-114
23436819-9	2013	AnxA5 overexpression slowed down Ca(2+) extrusion during caffeine application in adult rat cardiomyocytes.	Caffeine	57-65	annexin A5	Rattus norvegicus	0-5
23301724-4	2013	Caffeine had biphasic effects: 0.1 mM caffeine significantly enhanced mineralization and alkaline phosphatase (ALP) activity.	Caffeine	0-8	alkaline phosphatase, placental	Homo sapiens	89-109
23301724-4	2013	Caffeine had biphasic effects: 0.1 mM caffeine significantly enhanced mineralization and alkaline phosphatase (ALP) activity.	Caffeine	38-46	alkaline phosphatase, placental	Homo sapiens	89-109
23301724-4	2013	Caffeine had biphasic effects: 0.1 mM caffeine significantly enhanced mineralization and alkaline phosphatase (ALP) activity.	Caffeine	38-46	alkaline phosphatase, placental	Homo sapiens	111-114
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	alkaline phosphatase, placental	Homo sapiens	127-130
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	bone gamma-carboxyglutamate protein	Homo sapiens	135-146
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	bone gamma-carboxyglutamate protein	Homo sapiens	148-151
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	TNF receptor superfamily member 11b	Homo sapiens	167-182
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	TNF receptor superfamily member 11b	Homo sapiens	184-187
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	RUNX family transcription factor 2	Homo sapiens	190-225
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	RUNX family transcription factor 2	Homo sapiens	227-232
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	sirtuin 1	Homo sapiens	238-247
23301724-5	2013	Consistent with these observations, a caffeine concentration of 0.1 mM upregulated the osteogenic differentiation marker genes ALP and osteocalcin (OCN), and elevated osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2) and Sirtuin 1 (SIRT1) levels.	Caffeine	38-46	sirtuin 1	Homo sapiens	249-254
23301724-7	2013	These findings indicate that caffeine has a beneficial effect on ADSCs and bone marrow stromal cells, enhancing differentiation to osteoblasts; this effect, which is mediated via RUNX2 activation at low doses is significantly suppressed at high doses.	Caffeine	29-37	RUNX family transcription factor 2	Homo sapiens	179-184
23461670-5	2013	The protective effects of caffeine in SH-SY5Y cells disappeared with co-treatment by the adenosine A2A receptor agonist, CGS21680, and were mimicked by the adenosine A2A R antagonist, SCH58261.	Caffeine	26-34	adenosine A2a receptor	Homo sapiens	89-111
22873654-11	2013	The OVX and caffeine/OVX groups presented a greater number of TRAP(+) cells around unligated teeth than the control group (P &lt;0.05).	Caffeine	12-20	acid phosphatase 5, tartrate resistant	Rattus norvegicus	62-66
23930200-3	2013	Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.	Caffeine	52-60	ICR1 differentially methylated region	Homo sapiens	71-74
23930200-3	2013	Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.	Caffeine	52-60	protein tyrosine phosphatase receptor type J	Homo sapiens	132-136
23705030-8	2013	The ATM pharmacological inhibitor caffeine was found to effectively inhibit the activation of the ATM-dependent pathways and to rescue the ST-induced G2 arrest in GES-1 cells, which indicating its ATM-dependent characteristic.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	4-7
23705030-8	2013	The ATM pharmacological inhibitor caffeine was found to effectively inhibit the activation of the ATM-dependent pathways and to rescue the ST-induced G2 arrest in GES-1 cells, which indicating its ATM-dependent characteristic.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	98-101
23705030-8	2013	The ATM pharmacological inhibitor caffeine was found to effectively inhibit the activation of the ATM-dependent pathways and to rescue the ST-induced G2 arrest in GES-1 cells, which indicating its ATM-dependent characteristic.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	98-101
23698772-0	2013	Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase.	Caffeine	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
23415910-8	2013	DISCUSSION: These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-kappaB activation and subsequent TNF-alpha production.	Caffeine	40-48	tumor necrosis factor	Homo sapiens	176-185
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	36-44	butyrylcholinesterase	Homo sapiens	231-235
23698772-5	2013	In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission.	Caffeine	56-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	36-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	254-258
23698772-5	2013	In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission.	Caffeine	56-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	218-226	butyrylcholinesterase	Homo sapiens	161-165
23698772-5	2013	In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission.	Caffeine	56-64	butyrylcholinesterase	Homo sapiens	113-134
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	218-226	butyrylcholinesterase	Homo sapiens	231-235
23698772-5	2013	In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission.	Caffeine	56-64	butyrylcholinesterase	Homo sapiens	136-140
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	218-226	acetylcholinesterase (Cartwright blood group)	Homo sapiens	254-258
23698772-6	2013	A standard Ellman test with human AChE and BChE was done for altering concentrations of caffeine.	Caffeine	88-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38
23698772-6	2013	A standard Ellman test with human AChE and BChE was done for altering concentrations of caffeine.	Caffeine	88-96	butyrylcholinesterase	Homo sapiens	43-47
23698772-9	2013	In compliance with Dixon"s plot, caffeine was proved to be a non-competitive inhibitor of AChE and BChE.	Caffeine	33-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
23698772-9	2013	In compliance with Dixon"s plot, caffeine was proved to be a non-competitive inhibitor of AChE and BChE.	Caffeine	33-41	butyrylcholinesterase	Homo sapiens	99-103
23698772-13	2013	The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE.	Caffeine	36-44	butyrylcholinesterase	Homo sapiens	161-165
23558838-10	2013	Maximal contractures in the caffeine-halothane contracture test were greater in those who had a known MH mutation or variant of uncertain significance in RYR1 than in those who did not.	Caffeine	28-36	ryanodine receptor 1	Homo sapiens	154-158
23625556-9	2013	Caffeine reduced the appearance of all these morphological modifications, which were also abrogated in mice with a global A2A R inactivation (knockout).	Caffeine	0-8	adenosine A2a receptor	Mus musculus	122-127
23412805-2	2013	The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism.	Caffeine	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
23412805-2	2013	The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism.	Caffeine	58-66	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	15-21
23417043-3	2013	METHODS AND RESULTS: Ca(2+) waves were induced in mouse left ventricular cardiomyocytes by isoproterenol combined with caffeine to increase RyR Ca(2+) sensitivity.	Caffeine	119-127	ryanodine receptor 1, skeletal muscle	Mus musculus	140-143
23368839-6	2013	Furthermore, in vitro point mutations generated in PRS1 corresponding to missense mutations associated with human neuropathies or in the divalent cation and/or 5-phosphoribosyl-1(alpha)-pyrophosphate binding sites also display increased Rlm1 expression at 30  C and 37  C and most give rise to caffeine sensitivity.	Caffeine	294-302	ribose phosphate diphosphokinase subunit PRS1	Saccharomyces cerevisiae S288C	51-55
23434822-0	2013	Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	68-71
23434822-0	2013	Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.	Caffeine	0-8	melanocyte inducing transcription factor	Homo sapiens	83-87
23434822-0	2013	Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.	Caffeine	0-8	dendrocyte expressed seven transmembrane protein	Homo sapiens	92-100
23434822-0	2013	Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.	Caffeine	0-8	cathepsin K	Homo sapiens	101-105
23434822-0	2013	Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.	Caffeine	0-8	TRAP	Homo sapiens	110-114
23434822-4	2013	TRAP staining showed that the number of larger (&gt;100 mum) osteoclastic cells as well as of TRAP-positive multinucleated cells was increased by caffeine treatment.	Caffeine	146-154	TRAP	Homo sapiens	0-4
23434822-4	2013	TRAP staining showed that the number of larger (&gt;100 mum) osteoclastic cells as well as of TRAP-positive multinucleated cells was increased by caffeine treatment.	Caffeine	146-154	TRAP	Homo sapiens	94-98
23434822-5	2013	Among the MAP kinases, caffeine specifically activated p38 MAP kinase, which in turn, controlled osteoclast differentiation and maturation.	Caffeine	23-31	mitogen-activated protein kinase 14	Homo sapiens	55-58
23434822-6	2013	This is evidenced by the abolishment of activated p38 MAP kinase by pretreatment with SB203580, a p38-specific inhibitor, resulting in suppressed osteoclast differentiation and maturation that should be increased by caffeine.	Caffeine	216-224	mitogen-activated protein kinase 14	Homo sapiens	50-53
23434822-6	2013	This is evidenced by the abolishment of activated p38 MAP kinase by pretreatment with SB203580, a p38-specific inhibitor, resulting in suppressed osteoclast differentiation and maturation that should be increased by caffeine.	Caffeine	216-224	mitogen-activated protein kinase 14	Homo sapiens	98-101
23434822-7	2013	Caffeine significantly induced the expression of Mitf and pretreatment with SB203580 markedly suppressed the expression of Mitf induced by caffeine.	Caffeine	0-8	melanocyte inducing transcription factor	Homo sapiens	49-53
23434822-7	2013	Caffeine significantly induced the expression of Mitf and pretreatment with SB203580 markedly suppressed the expression of Mitf induced by caffeine.	Caffeine	0-8	melanocyte inducing transcription factor	Homo sapiens	123-127
23434822-7	2013	Caffeine significantly induced the expression of Mitf and pretreatment with SB203580 markedly suppressed the expression of Mitf induced by caffeine.	Caffeine	139-147	melanocyte inducing transcription factor	Homo sapiens	123-127
23434822-8	2013	Whereas it failed to regulate the expression of NFATc1 and Oscar, the expressions of Cathepsin K and TRAP were induced by caffeine treatment in primary preosteoclasts.	Caffeine	122-130	cathepsin K	Homo sapiens	85-96
23434822-8	2013	Whereas it failed to regulate the expression of NFATc1 and Oscar, the expressions of Cathepsin K and TRAP were induced by caffeine treatment in primary preosteoclasts.	Caffeine	122-130	TRAP	Homo sapiens	101-105
23434822-9	2013	Real-time PCR and luciferase assays showed that the increase of osteoclastic cell-cell fusion by caffeine was through the transcriptional up-regulation of DC-STAMP expression but not of Atp6v0d2.	Caffeine	97-105	dendrocyte expressed seven transmembrane protein	Homo sapiens	155-163
23434822-9	2013	Real-time PCR and luciferase assays showed that the increase of osteoclastic cell-cell fusion by caffeine was through the transcriptional up-regulation of DC-STAMP expression but not of Atp6v0d2.	Caffeine	97-105	ATPase H+ transporting V0 subunit d2	Homo sapiens	186-194
23434822-10	2013	These results strongly suggest that caffeine directly enhances osteoclast differentiation and maturation through p38 MAP kinase activation, thus inducing Mitf expression and transcriptional activation of DC-STAMP, and finally CtsK and TRAP.	Caffeine	36-44	mitogen-activated protein kinase 14	Homo sapiens	113-116
23434822-10	2013	These results strongly suggest that caffeine directly enhances osteoclast differentiation and maturation through p38 MAP kinase activation, thus inducing Mitf expression and transcriptional activation of DC-STAMP, and finally CtsK and TRAP.	Caffeine	36-44	melanocyte inducing transcription factor	Homo sapiens	154-158
23434822-10	2013	These results strongly suggest that caffeine directly enhances osteoclast differentiation and maturation through p38 MAP kinase activation, thus inducing Mitf expression and transcriptional activation of DC-STAMP, and finally CtsK and TRAP.	Caffeine	36-44	dendrocyte expressed seven transmembrane protein	Homo sapiens	204-212
23434822-10	2013	These results strongly suggest that caffeine directly enhances osteoclast differentiation and maturation through p38 MAP kinase activation, thus inducing Mitf expression and transcriptional activation of DC-STAMP, and finally CtsK and TRAP.	Caffeine	36-44	cathepsin K	Homo sapiens	226-230
23434822-10	2013	These results strongly suggest that caffeine directly enhances osteoclast differentiation and maturation through p38 MAP kinase activation, thus inducing Mitf expression and transcriptional activation of DC-STAMP, and finally CtsK and TRAP.	Caffeine	36-44	TRAP	Homo sapiens	235-239
23368839-8	2013	The correlation between caffeine sensitivity and increased basal expression of Rlm1 in the altered versions of PRS1 can be extended to their inability to rescue the synthetic lethality of a prs1Delta prs5Delta strain implying that impaired CWI may contribute to the observed loss of viability.	Caffeine	24-32	ribose phosphate diphosphokinase subunit PRS1	Saccharomyces cerevisiae S288C	111-115
23536488-0	2013	Caffeine improved paroxysmal dyskinesia caused by the PRRT2 mutation.	Caffeine	0-8	proline rich transmembrane protein 2	Homo sapiens	54-59
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Caffeine	208-216	lysine acetyltransferase 2B	Homo sapiens	183-186
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Caffeine	208-216	lysine acetyltransferase 2B	Homo sapiens	201-204
23945308-9	2013	With 20 mmol/L caffeine and 100 micromol/L carbachol which stimulated Ca2+ release respectively from internal ryanodine receptor (RYR) and inositol triphosphate (IP3) Ca2+ storage, the fluorescence intensity F/F0 curve presented a peak pattern.	Caffeine	15-23	ryanodine receptor 2	Rattus norvegicus	130-133
23492909-3	2013	METHODS: CYP1A2 activity was determined by the paraxanthine/caffeine ratio in 184 smokers and in 113 of them who were abstinent for 4 weeks.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15
23601316-10	2013	A similar interplay between RyR sensitivity and SR content was observed during treatment of myocytes with low-dose caffeine.	Caffeine	115-123	ryanodine receptor 1, skeletal muscle	Mus musculus	28-31
22561003-0	2013	Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.	Caffeine	0-8	solute carrier family 6 member 3	Rattus norvegicus	41-61
23167834-4	2013	CYP1A2 activities were evaluated by plasma 1,7-dimethylxanthine/caffeine ratios (17X/137X) after administration of 100-mg caffeine.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
23167834-4	2013	CYP1A2 activities were evaluated by plasma 1,7-dimethylxanthine/caffeine ratios (17X/137X) after administration of 100-mg caffeine.	Caffeine	122-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
23167834-9	2013	CYP1A2 genetic polymorphisms influenced CYP1A2 enzyme activity as measured by caffeine, but CYP1A2 gene polymorphisms appeared to have limited influence on theophylline metabolism in our study.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
23615262-0	2013	Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells.	Caffeine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	57-85
23615262-3	2013	Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR).	Caffeine	0-8	sterol regulatory element binding transcription factor 1	Homo sapiens	67-74
23615262-3	2013	Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR).	Caffeine	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	76-82
23615262-3	2013	Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR).	Caffeine	0-8	stearoyl-CoA desaturase	Homo sapiens	89-93
23615262-3	2013	Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR).	Caffeine	0-8	high mobility group AT-hook 1	Homo sapiens	95-99
23615262-3	2013	Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR).	Caffeine	0-8	low density lipoprotein receptor	Homo sapiens	104-108
23615262-5	2013	Next, the effect of caffeine on AMP-activated protein kinase (AMPK) signaling pathway was examined.	Caffeine	20-28	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	32-60
23615262-5	2013	Next, the effect of caffeine on AMP-activated protein kinase (AMPK) signaling pathway was examined.	Caffeine	20-28	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	62-66
23615262-6	2013	Phosphorylation of AMPK and acetyl-CoA carboxylase were evidently increased when the cells were treated with caffeine as indicated for 24 h. These effects were all reversed in the presence of compound C, an AMPK inhibitor.	Caffeine	109-117	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	19-23
23615262-6	2013	Phosphorylation of AMPK and acetyl-CoA carboxylase were evidently increased when the cells were treated with caffeine as indicated for 24 h. These effects were all reversed in the presence of compound C, an AMPK inhibitor.	Caffeine	109-117	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	207-211
23615262-7	2013	In summary, these data indicate that caffeine effectively depleted TG and cholesterol levels by inhibition of lipogenesis and stimulation of lipolysis through modulating AMPK-SREBP signaling pathways.	Caffeine	37-45	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	170-174
23560237-7	2013	FACS analysis and DAPI staining showed that inhibitory effect of caffeine on HUVEC proliferation was the result of apoptosis and the up-regulation of thrombospondin-1 (TSP-1).	Caffeine	65-73	thrombospondin 1	Homo sapiens	150-166
23325319-7	2013	Ryanodine receptor (RyR) calcium release channels showed lower sensitivity to caffeine in SepN deficient myofibers, suggesting a possible role of SepN in RyR regulation.	Caffeine	78-86	ryanodine receptor 1, skeletal muscle	Mus musculus	0-18
23325319-7	2013	Ryanodine receptor (RyR) calcium release channels showed lower sensitivity to caffeine in SepN deficient myofibers, suggesting a possible role of SepN in RyR regulation.	Caffeine	78-86	ryanodine receptor 1, skeletal muscle	Mus musculus	20-23
23325319-7	2013	Ryanodine receptor (RyR) calcium release channels showed lower sensitivity to caffeine in SepN deficient myofibers, suggesting a possible role of SepN in RyR regulation.	Caffeine	78-86	selenoprotein N	Mus musculus	90-94
23325319-7	2013	Ryanodine receptor (RyR) calcium release channels showed lower sensitivity to caffeine in SepN deficient myofibers, suggesting a possible role of SepN in RyR regulation.	Caffeine	78-86	ryanodine receptor 1, skeletal muscle	Mus musculus	154-157
23361938-3	2013	SOD1(G93A) mice received caffeine through drinking water from 70 days of age until death.	Caffeine	25-33	superoxide dismutase 1, soluble	Mus musculus	0-4
23361938-6	2013	The results showed that caffeine intake significantly shortened the survival of SOD1(G93A) mice (log rank test, P = 0.01) and induced a nonsignificant advancing of disease onset.	Caffeine	24-32	superoxide dismutase 1, soluble	Mus musculus	80-84
23135367-7	2013	The LEx group showed an exercise-induced increase in valine (~29%), which was inhibited by caffeine.	Caffeine	91-99	fucosyltransferase 4	Homo sapiens	4-7
23331476-0	2013	Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus.	Caffeine	68-76	insulin	Homo sapiens	135-142
23331476-1	2013	BACKGROUND: Compounds other than macronutrients have been shown to influence blood glucose concentrations and insulin sensitivity in people with diabetes, with caffeine being one such substance.	Caffeine	160-168	insulin	Homo sapiens	110-117
23331476-7	2013	Trials in people with type II diabetes demonstrated that the ingestion of caffeine (approximately 200-500 mg) significantly increased blood glucose concentrations by 16-28% of the area under the curve (AUC) and insulin concentrations by 19-48% of the AUC when taken prior to a glucose load, at the same time as decreasing insulin sensitivity by 14-37%.	Caffeine	74-82	insulin	Homo sapiens	211-218
23331476-7	2013	Trials in people with type II diabetes demonstrated that the ingestion of caffeine (approximately 200-500 mg) significantly increased blood glucose concentrations by 16-28% of the area under the curve (AUC) and insulin concentrations by 19-48% of the AUC when taken prior to a glucose load, at the same time as decreasing insulin sensitivity by 14-37%.	Caffeine	74-82	insulin	Homo sapiens	322-329
23331476-9	2013	In GDM, a single trial demonstrated that approximately 200 mg of caffeine induced a decrease in insulin sensitivity by 18% and a subsequent increase in blood glucose concentrations by 19% of the AUC.	Caffeine	65-73	insulin	Homo sapiens	96-103
23313844-7	2013	We conclude that the beneficial and anti-inflammatory effects of caffeine in the lungs of newborn rats may be due to increased TLR9 levels.	Caffeine	65-73	toll-like receptor 9	Rattus norvegicus	127-131
23560237-7	2013	FACS analysis and DAPI staining showed that inhibitory effect of caffeine on HUVEC proliferation was the result of apoptosis and the up-regulation of thrombospondin-1 (TSP-1).	Caffeine	65-73	thrombospondin 1	Homo sapiens	168-173
23560237-8	2013	Furthermore, TSP-1 levels were down-regulated by NECA but were unaffected by CGS21680, indicating that caffeine regulated TSP-1 expression via adenosine A2B receptor.	Caffeine	103-111	thrombospondin 1	Homo sapiens	13-18
23560237-8	2013	Furthermore, TSP-1 levels were down-regulated by NECA but were unaffected by CGS21680, indicating that caffeine regulated TSP-1 expression via adenosine A2B receptor.	Caffeine	103-111	thrombospondin 1	Homo sapiens	122-127
23560237-9	2013	In addition, caffeine up-regulated caspase-3 and down-regulated Bcl-2 at the protein level.	Caffeine	13-21	caspase 3	Homo sapiens	35-44
23560237-9	2013	In addition, caffeine up-regulated caspase-3 and down-regulated Bcl-2 at the protein level.	Caffeine	13-21	BCL2 apoptosis regulator	Homo sapiens	64-69
23560237-10	2013	These results suggest that the inhibitory effect of caffeine on angiogenesis is associated, at least in part, with its induction of endothelial cell apoptosis, probably mediated by a caspase-3 dependent mechanism.	Caffeine	52-60	caspase 3	Homo sapiens	183-192
23011927-9	2013	Significant elevations in HSP72 protein and mRNA and in HSF1 protein levels were noted only in liver by alcohol alone or in combination with caffeine.	Caffeine	141-149	heat shock protein 1A	Mus musculus	26-31
23298795-8	2013	More importantly, the inhibitory effect of caffeine on AMPK activity was attenuated by the PP2A inhibitor, calyculin A or siRNA induced knockdown of PP2A.	Caffeine	43-51	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	91-95
23298795-8	2013	More importantly, the inhibitory effect of caffeine on AMPK activity was attenuated by the PP2A inhibitor, calyculin A or siRNA induced knockdown of PP2A.	Caffeine	43-51	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	149-153
23239156-11	2013	TMEM16A deletion renders Ca(2+) sparks unable to activate Cl((Ca)) currents, and weakens caffeine- and methacholine-induced cell shortening.	Caffeine	89-97	anoctamin 1, calcium activated chloride channel	Mus musculus	0-7
23211442-3	2013	It was found that tea polyphenols (TP), tea polysaccharides (TPS), caffeine (Caf), protein (Pro), amino acids (AA) were accumulated in several fractions after solvent extraction despite not being separated completely.	Caffeine	67-75	caffeine susceptibility	Mus musculus	77-80
23262392-4	2013	We investigated the effects of caffeine on the activity of EAAT3 and the involvement of protein kinase C (PKC) and phosphatidylinositol 3-kinase (PI3K).	Caffeine	31-39	solute carrier family 1 member 1	Rattus norvegicus	59-64
23262392-7	2013	Caffeine decreased EAAT3 activity in a dose-dependent manner.	Caffeine	0-8	solute carrier family 1 member 1	Rattus norvegicus	19-24
23262392-9	2013	When preincubated oocytes with phorbol-12-myristate-13-acetate (PMA, a PKC activator) were exposed to caffeine, PMA-induced increase in EAAT3 activity was abolished.	Caffeine	102-110	solute carrier family 1 member 1	Rattus norvegicus	136-141
23262392-13	2013	Our results demonstrate that caffeine attenuates EAAT3 activity and this reducing effect of caffeine seems to be mediated by PKC and PI3K.	Caffeine	29-37	solute carrier family 1 member 1	Rattus norvegicus	49-54
23262392-13	2013	Our results demonstrate that caffeine attenuates EAAT3 activity and this reducing effect of caffeine seems to be mediated by PKC and PI3K.	Caffeine	92-100	solute carrier family 1 member 1	Rattus norvegicus	49-54
22628494-6	2013	A caffeine test was used to assess CYP1A2 and NAT2 activities in 635 cases and 845 controls.	Caffeine	2-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	35-41
23339054-2	2013	METHODS: We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson"s Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson"s severity, site, and initial treatment with pramipexole or levodopa.	Caffeine	97-105	synaptosome associated protein 91	Homo sapiens	235-239
23438224-0	2013	Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women.	Caffeine	0-8	insulin	Homo sapiens	27-34
23460944-4	2013	METHODS: The entire coding region of CASQ1 in 75 unrelated patients diagnosed by caffeine-halothane contracture test as MH susceptible (MHS) was analyzed by DNA sequencing.	Caffeine	81-89	calsequestrin 1	Homo sapiens	37-42
23438224-11	2013	Increasing caffeine consumption by 1 mg kg(-1) of BW increased insulin and C-peptide AUCs by 5.8% and 8.7%, respectively.	Caffeine	11-19	insulin	Homo sapiens	63-70
23438224-13	2013	These results showed that caffeine ingestion disrupted insulin sensitivity in a dose-dependent fashion beginning at very low doses (0-1 mg kg(-1) BW) in both healthy men and women.	Caffeine	26-34	insulin	Homo sapiens	55-62
23148318-7	2013	Supraphysiological stimulation of rat skeletal muscle in vitro by repeated tetanic stimulation in 30 mm caffeine also produced marked proteolysis of JP1 (and not RyR1).	Caffeine	104-112	junctophilin 1	Rattus norvegicus	149-152
22699886-10	2013	After adjusting for multiple factors, caffeine intake in the highest quartile (&gt;=204 mg/day) was associated with any UI [prevalence odds ratio (POR) 1.47, 95 % confidence interval (CI) 1.07-2.01], but not moderate/severe UI (POR 1.42, 95 % CI 0.98-2.07).	Caffeine	38-46	ADP ribosylation factor interacting protein 2	Homo sapiens	228-233
23177664-6	2013	To assess RyR function, contraction was then measured in RA and RVC exposed to the RyR activator caffeine (20mM).	Caffeine	97-105	ryanodine receptor 2	Rattus norvegicus	83-86
23177664-7	2013	In RA, caffeine caused contraction that was attenuated by the RyR antagonists ryanodine (10muM) and tetracaine (100muM).	Caffeine	7-15	ryanodine receptor 2	Rattus norvegicus	62-65
23278694-3	2013	METHODS: CYP1A2 activity was determined using the 4-h paraxanthine/caffeine saliva concentration ratio following a 100-mg oral dose of caffeine in healthy individuals of South Asian (n = 11) and European (n = 12) ancestry.	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15
23009754-3	2013	Attacks of motor dysfunction in the Ca(V)2.1 calcium channel mouse mutant tottering are also triggered by stress, caffeine and ethanol.	Caffeine	114-122	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	36-44
23278694-3	2013	METHODS: CYP1A2 activity was determined using the 4-h paraxanthine/caffeine saliva concentration ratio following a 100-mg oral dose of caffeine in healthy individuals of South Asian (n = 11) and European (n = 12) ancestry.	Caffeine	135-143	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15
23009754-8	2013	In fact, stress, caffeine and alcohol precipitated attacks in Ca(V)2.1 mutant mice in which genetic pathology was limited to cerebellar Purkinje cells, suggesting that the triggers initiate dysfunction within a specific brain region.	Caffeine	17-25	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	62-70
23220362-0	2013	Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	109-113
23099892-3	2013	Using the canonical Protein Kinase A (PKA) pathway as a test system, we show that changes in PKA activity can be measured in living cells as a modulation of the interaction between its regulatory (Bcy1) and catalytic (Tpk1 and Tpk2) subunits in response to changes in carbon metabolism, caffeine and methyl methanesulfonate (MMS) treatments and to modifications in the dosage of its enzymatic regulators, the phosphodiesterases.	Caffeine	287-295	cAMP-dependent protein kinase regulatory subunit BCY1	Saccharomyces cerevisiae S288C	197-201
23099892-3	2013	Using the canonical Protein Kinase A (PKA) pathway as a test system, we show that changes in PKA activity can be measured in living cells as a modulation of the interaction between its regulatory (Bcy1) and catalytic (Tpk1 and Tpk2) subunits in response to changes in carbon metabolism, caffeine and methyl methanesulfonate (MMS) treatments and to modifications in the dosage of its enzymatic regulators, the phosphodiesterases.	Caffeine	287-295	cAMP-dependent protein kinase catalytic subunit TPK1	Saccharomyces cerevisiae S288C	218-222
23099892-3	2013	Using the canonical Protein Kinase A (PKA) pathway as a test system, we show that changes in PKA activity can be measured in living cells as a modulation of the interaction between its regulatory (Bcy1) and catalytic (Tpk1 and Tpk2) subunits in response to changes in carbon metabolism, caffeine and methyl methanesulfonate (MMS) treatments and to modifications in the dosage of its enzymatic regulators, the phosphodiesterases.	Caffeine	287-295	cAMP-dependent protein kinase catalytic subunit TPK2	Saccharomyces cerevisiae S288C	227-231
23220362-6	2013	Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals.	Caffeine	154-162	brain-derived neurotrophic factor	Rattus norvegicus	212-245
23220362-6	2013	Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals.	Caffeine	154-162	brain-derived neurotrophic factor	Rattus norvegicus	247-251
23220362-8	2013	Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.	Caffeine	37-45	brain-derived neurotrophic factor	Rattus norvegicus	22-26
23220362-8	2013	Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.	Caffeine	109-117	brain-derived neurotrophic factor	Rattus norvegicus	22-26
22940476-4	2013	Stratification by SOAs revealed that at 120 ms and 240 ms SOAs in the caffeine condition, PPI was impaired in female ADORA2A 1976TT risk genotype carriers as compared to male ADORA2A 1976TT homozygotes, while no significant effects were observed in the ADORA2A 1976CC/CT non-risk genotype or placebo group.	Caffeine	70-78	adenosine A2a receptor	Homo sapiens	117-124
24453686-5	2013	However, the decrease in cell proliferation caused by caffeine was lower than in the control group and significantly increased the expression of gene transcripts for chondrogenic differentiation, represented by Sox-9 and Runx-2.	Caffeine	54-62	SRY-box transcription factor 9	Rattus norvegicus	211-216
22940476-6	2013	The present results point to an impaired ability to selectively process very early information and to gate irrelevant sensory information, respectively, in female ADORA2A 1976TT homozygotes in response to caffeine, providing further evidence for the adenosinergic system to be involved in the pathogenesis of anxiety.	Caffeine	205-213	adenosine A2a receptor	Homo sapiens	163-170
23142373-9	2013	Adenosine A(1) receptor interactions are worthy of attention, as chronic oral caffeine (0.1, 0.3g/L, doses considered relevant to human intake levels) blocked antinociception by systemic amitriptyline in normal mice.	Caffeine	78-86	adenosine A1 receptor	Homo sapiens	0-23
24453686-5	2013	However, the decrease in cell proliferation caused by caffeine was lower than in the control group and significantly increased the expression of gene transcripts for chondrogenic differentiation, represented by Sox-9 and Runx-2.	Caffeine	54-62	RUNX family transcription factor 2	Rattus norvegicus	221-227
22795305-5	2013	Using the same conditions, the matrix influence (surface water - SW and sewage treatment plant effluent - STP) on caffeine degradation was also evaluated.	Caffeine	114-122	thyroid hormone receptor interactor 10	Homo sapiens	106-109
23151535-7	2013	Only caffeine-free ASB intake in NHS participants was associated with a higher risk of T2D (RR: 6% per serving; P &lt; 0.001).	Caffeine	5-13	arylsulfatase B	Homo sapiens	19-22
22695883-1	2013	A specific ultra-performance liquid chromatography tandem mass spectrometry method has been described for the simultaneous determination of caffeine, tolbutamide, metoprolol and dapsone in rat plasma, which are the four probe drugs of the four cytochrome P450 (CYP450) isoforms CYP1A2, CYP2C9, CYP2D6 and CYP3A4.	Caffeine	140-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	244-259
22850738-4	2013	Using caffeine as a probe, in vivo CYP2A6 activity was estimated by the 17U/17X urinary ratio.	Caffeine	6-14	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	35-41
24555232-4	2013	It is recommended to evaluate the activity of CYP1A2 by determining the MR for one of two caffeine metabolites, paraxanthine or theobromine, and the activity of CYP2C9 by determining the MR of metabolite Exp-3174 to losartan.	Caffeine	90-98	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	46-52
23935682-2	2013	The presence of caffeine within green tea has caused limitations.	Caffeine	16-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	38-41
23321652-9	2013	Increasing vaginal delivery and decreasing caffeine intake (but not age or other demographic factors) were associated with incorrect PFM contraction; only decreased caffeine intake remained significant on multivariable analysis.	Caffeine	43-51	msh homeobox 2	Homo sapiens	133-136
23241554-5	2013	Caffeine consumption (1 g/L in the drinking water starting 2 weeks before the STZ challenge) prevented the STZ-induced memory impairment and neurodegeneration as well as the upregulation of A2AR.	Caffeine	0-8	adenosine A2a receptor	Rattus norvegicus	190-194
23241554-6	2013	These findings provide the first demonstration that caffeine prevents sporadic dementia and implicate the control of central A2AR as its likely mechanism of action.	Caffeine	52-60	adenosine A2a receptor	Rattus norvegicus	125-129
22695883-1	2013	A specific ultra-performance liquid chromatography tandem mass spectrometry method has been described for the simultaneous determination of caffeine, tolbutamide, metoprolol and dapsone in rat plasma, which are the four probe drugs of the four cytochrome P450 (CYP450) isoforms CYP1A2, CYP2C9, CYP2D6 and CYP3A4.	Caffeine	140-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	261-267
22695883-1	2013	A specific ultra-performance liquid chromatography tandem mass spectrometry method has been described for the simultaneous determination of caffeine, tolbutamide, metoprolol and dapsone in rat plasma, which are the four probe drugs of the four cytochrome P450 (CYP450) isoforms CYP1A2, CYP2C9, CYP2D6 and CYP3A4.	Caffeine	140-148	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	278-284
22695883-1	2013	A specific ultra-performance liquid chromatography tandem mass spectrometry method has been described for the simultaneous determination of caffeine, tolbutamide, metoprolol and dapsone in rat plasma, which are the four probe drugs of the four cytochrome P450 (CYP450) isoforms CYP1A2, CYP2C9, CYP2D6 and CYP3A4.	Caffeine	140-148	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	294-300
22841916-0	2013	Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats.	Caffeine	8-16	brain-derived neurotrophic factor	Rattus norvegicus	81-85
22706686-0	2013	Chronic caffeine treatment prevents stress-induced LTP impairment: the critical role of phosphorylated CaMKII and BDNF.	Caffeine	8-16	brain-derived neurotrophic factor	Rattus norvegicus	114-118
22706686-15	2013	This may include preservation of basal levels of BDNF by chronic caffeine treatment in stressed animals.	Caffeine	65-73	brain-derived neurotrophic factor	Rattus norvegicus	49-53
22706686-16	2013	These findings highlight the critical role of P-CaMKII and BDNF in caffeine-induced prevention of stress-induced LTP impairment.	Caffeine	67-75	brain-derived neurotrophic factor	Rattus norvegicus	59-63
22841916-2	2013	Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats.	Caffeine	199-207	brain-derived neurotrophic factor	Rattus norvegicus	43-47
22841916-2	2013	Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats.	Caffeine	199-207	brain-derived neurotrophic factor	Rattus norvegicus	89-93
23095976-0	2013	Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia.	Caffeine	0-8	plasmacytoma expressed transcript 1	Mus musculus	54-59
22841916-2	2013	Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats.	Caffeine	199-207	brain-derived neurotrophic factor	Rattus norvegicus	89-93
22841916-3	2013	Caffeine treatment substantially reduced i) age-related impairments in the two types of memory in an inhibitory avoidance paradigm, and ii) parallel increases in hippocampal BDNF levels.	Caffeine	0-8	brain-derived neurotrophic factor	Rattus norvegicus	174-178
22841916-4	2013	In addition, chronic caffeine increased proBDNF and CREB concentrations, and decreased TrkB levels, in hippocampus regardless of age.	Caffeine	21-29	cAMP responsive element binding protein 1	Rattus norvegicus	52-56
22841916-4	2013	In addition, chronic caffeine increased proBDNF and CREB concentrations, and decreased TrkB levels, in hippocampus regardless of age.	Caffeine	21-29	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	87-91
22841916-5	2013	These data provide new evidence in favor of the hypothesis that modifications in BDNF and related proteins in the hippocampus contribute to the pro-cognitive effects of caffeine on age-associated losses in memory encoding.	Caffeine	169-177	brain-derived neurotrophic factor	Rattus norvegicus	81-85
24070239-7	2013	An antibody array revealed that caffeine plus RW administered to mice fed a high-fat diet and irradiated with UVB decreased the epidermal levels of lipopolysaccharide-induced CXC chemokine, soluble TNF alpha receptor-1, and macrophage inflammatory protein-1gamma.	Caffeine	32-40	chemokine (C-C motif) ligand 9	Mus musculus	198-262
23530639-2	2013	Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations.	Caffeine	66-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-32
23530639-2	2013	Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations.	Caffeine	66-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	34-40
23095976-2	2013	We hypothesized that caffeine, a respiratory stimulant, would hasten the onset of gasping and improve autoresuscitation in 5-HT-deficient, Pet-1(-/-) mice.	Caffeine	21-29	plasmacytoma expressed transcript 1	Mus musculus	139-144
23095976-8	2013	RESULTS: Caffeine had a dose-dependent effect of hastening the onset of gasping, recovery of breathing, and restoration of HR in Pet-1(-/-) (but not in wild-type) rodents, thereby improving survival across asphyxic episodes.	Caffeine	9-17	plasmacytoma expressed transcript 1	Mus musculus	129-134
22752580-2	2013	Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine"s inhibition of UVB-induced carcinogenesis.	Caffeine	13-21	ataxia telangiectasia and Rad3 related	Mus musculus	66-69
23555814-0	2013	The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.	Caffeine	49-57	Structural maintenance of chromosomes 5	Drosophila melanogaster	4-8
23555814-0	2013	The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.	Caffeine	49-57	java no jive	Drosophila melanogaster	9-13
23555814-0	2013	The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.	Caffeine	49-57	MAGE	Drosophila melanogaster	14-18
23555814-2	2013	To identify novel components in the DNA repair pathway, we carried out a genetic screen to identify mutations that confer reduced resistance to the genotoxic effects of caffeine, which inhibits the ATM and ATR DNA damage response proteins.	Caffeine	169-177	telomere fusion	Drosophila melanogaster	198-201
23555814-2	2013	To identify novel components in the DNA repair pathway, we carried out a genetic screen to identify mutations that confer reduced resistance to the genotoxic effects of caffeine, which inhibits the ATM and ATR DNA damage response proteins.	Caffeine	169-177	meiotic 41	Drosophila melanogaster	206-209
23555814-4	2013	The fact that Smc5 mutants are also caffeine-sensitive and that Mage physically interacts with Drosophila homologs of Nse proteins suggests that the structure of the Smc5/6 complex is conserved in Drosophila.	Caffeine	36-44	Structural maintenance of chromosomes 5	Drosophila melanogaster	14-18
23555814-8	2013	Rather, caffeine-induced apoptosis in these mutants is exacerbated by inhibition of ATM or ATR checkpoint kinases but suppressed by Rad51 depletion, suggesting a functional interaction involving homologous DNA repair pathways that deserves further scrutiny.	Caffeine	8-16	telomere fusion	Drosophila melanogaster	84-87
23555814-8	2013	Rather, caffeine-induced apoptosis in these mutants is exacerbated by inhibition of ATM or ATR checkpoint kinases but suppressed by Rad51 depletion, suggesting a functional interaction involving homologous DNA repair pathways that deserves further scrutiny.	Caffeine	8-16	meiotic 41	Drosophila melanogaster	91-94
23555814-8	2013	Rather, caffeine-induced apoptosis in these mutants is exacerbated by inhibition of ATM or ATR checkpoint kinases but suppressed by Rad51 depletion, suggesting a functional interaction involving homologous DNA repair pathways that deserves further scrutiny.	Caffeine	8-16	spindle A	Drosophila melanogaster	132-137
23460790-8	2013	Calcium fluxes induced by caffeine, a RyR agonist, were decreased by an IP3R blocker.	Caffeine	26-34	ryanodine receptor 2	Rattus norvegicus	38-41
23460790-8	2013	Calcium fluxes induced by caffeine, a RyR agonist, were decreased by an IP3R blocker.	Caffeine	26-34	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	72-76
23117134-6	2013	Caffeine decreased (P &lt; 0.05) both the number of total uterine PMNs and expression of IL-8 mRNA in the endometrium after AI.	Caffeine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23117134-9	2013	In conclusion, the addition of caffeine to the thawing solution inhibited migration of uterine PMNs, probably by downregulating IL-8 mRNA expression in the endometrium.	Caffeine	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
24145078-1	2013	BACKGROUND: Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in immature rats.	Caffeine	37-45	S100 calcium binding protein A10	Rattus norvegicus	57-60
24145078-5	2013	RESULTS: RMA episodes elicited by the 20 + 20 mg/kg dose of PTZ in adult rats exposed to caffeine at P7 to P11 were decreased.	Caffeine	89-97	S100 calcium binding protein A10	Rattus norvegicus	107-110
23099337-4	2013	Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium"s effect on catalase and GSP-Px activity.	Caffeine	0-8	catalase	Rattus norvegicus	33-41
23099337-4	2013	Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium"s effect on catalase and GSP-Px activity.	Caffeine	0-8	catalase	Rattus norvegicus	113-121
22752580-2	2013	Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine"s inhibition of UVB-induced carcinogenesis.	Caffeine	13-21	checkpoint kinase 1	Mus musculus	70-74
22752580-2	2013	Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine"s inhibition of UVB-induced carcinogenesis.	Caffeine	113-121	ataxia telangiectasia and Rad3 related	Mus musculus	66-69
22752580-2	2013	Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine"s inhibition of UVB-induced carcinogenesis.	Caffeine	113-121	checkpoint kinase 1	Mus musculus	70-74
22944195-4	2012	We find that cultured muscle cells derived from Eif4a3 morphants do not contract, and fail to undergo calcium-dependent calcium release in response to electrical stimulation or treatment with caffeine.	Caffeine	192-200	eukaryotic translation initiation factor 4A3, gene 1 S homeolog	Xenopus laevis	48-54
22974838-4	2012	In addition, caffeine significantly decreased LPS-induced DNA-binding activity of nuclear factor-kappaB (NF-kappaB) by suppressing the nuclear translocation of p50 and p65 subunits.	Caffeine	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	160-163
22953961-6	2012	Moreover, CC and caffeine protected primary neurons from Abeta-induced cell death and suppressed Abeta-induced caspase-3 activity.	Caffeine	17-25	caspase 3	Mus musculus	111-120
22974838-4	2012	In addition, caffeine significantly decreased LPS-induced DNA-binding activity of nuclear factor-kappaB (NF-kappaB) by suppressing the nuclear translocation of p50 and p65 subunits.	Caffeine	13-21	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	168-171
22974838-0	2012	Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation.	Caffeine	0-8	thymoma viral proto-oncogene 1	Mus musculus	86-89
22974838-0	2012	Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	124-127
22974838-6	2012	In addition, we elucidated that inhibition of Akt phosphorylation plays a crucial role in caffeine-mediated NF-kappaB regulation in LPS-stimulated BV2 microglial cells.	Caffeine	90-98	thymoma viral proto-oncogene 1	Mus musculus	46-49
22974838-2	2012	Caffeine substantially suppressed the LPS-induced pro-inflammatory mediators nitric oxide (NO), prostaglandin E(2) (PGE(2)) and tumor necrosis factor-alpha (TNF-alpha) in BV2 microglial cells.	Caffeine	0-8	tumor necrosis factor	Mus musculus	128-155
22974838-2	2012	Caffeine substantially suppressed the LPS-induced pro-inflammatory mediators nitric oxide (NO), prostaglandin E(2) (PGE(2)) and tumor necrosis factor-alpha (TNF-alpha) in BV2 microglial cells.	Caffeine	0-8	tumor necrosis factor	Mus musculus	157-166
22974838-7	2012	Caffeine also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and a specific inhibitor of ERK, PD98059, subsequently downregulated the expression of the pro-inflammatory genes iNOS, COX-2 and TNF-alpha.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	60-97
22974838-7	2012	Caffeine also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and a specific inhibitor of ERK, PD98059, subsequently downregulated the expression of the pro-inflammatory genes iNOS, COX-2 and TNF-alpha.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	99-102
23136995-7	2012	Our results show that caffeine intake increased the concentrations of T and DHT, organ weight, epithelial cell proliferation and AR tissue expression in the ventral prostatic lobe.	Caffeine	22-30	androgen receptor	Rattus norvegicus	129-131
22974838-7	2012	Caffeine also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and a specific inhibitor of ERK, PD98059, subsequently downregulated the expression of the pro-inflammatory genes iNOS, COX-2 and TNF-alpha.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	132-135
22974838-7	2012	Caffeine also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and a specific inhibitor of ERK, PD98059, subsequently downregulated the expression of the pro-inflammatory genes iNOS, COX-2 and TNF-alpha.	Caffeine	0-8	nitric oxide synthase 2, inducible	Mus musculus	218-222
22974838-7	2012	Caffeine also attenuated the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and a specific inhibitor of ERK, PD98059, subsequently downregulated the expression of the pro-inflammatory genes iNOS, COX-2 and TNF-alpha.	Caffeine	0-8	tumor necrosis factor	Mus musculus	234-243
22974838-8	2012	Taken together, our data indicate that caffeine suppresses the generation of pro-inflammatory mediators, such as NO, PGE(2) and TNF-alpha as well as their regulatory genes in LPS-stimulated BV2 microglial cells by inhibiting Akt-dependent NF-kappaB activation and the ERK signaling pathway.	Caffeine	39-47	tumor necrosis factor	Mus musculus	128-137
22974838-8	2012	Taken together, our data indicate that caffeine suppresses the generation of pro-inflammatory mediators, such as NO, PGE(2) and TNF-alpha as well as their regulatory genes in LPS-stimulated BV2 microglial cells by inhibiting Akt-dependent NF-kappaB activation and the ERK signaling pathway.	Caffeine	39-47	thymoma viral proto-oncogene 1	Mus musculus	225-228
22974838-8	2012	Taken together, our data indicate that caffeine suppresses the generation of pro-inflammatory mediators, such as NO, PGE(2) and TNF-alpha as well as their regulatory genes in LPS-stimulated BV2 microglial cells by inhibiting Akt-dependent NF-kappaB activation and the ERK signaling pathway.	Caffeine	39-47	mitogen-activated protein kinase 1	Mus musculus	268-271
22612345-2	2012	We have shown in a mouse model that during primary cardiac morphogenesis, acute maternal hypoxia negatively affects fetal heart rate, and recurrent maternal caffeine exposure reduces fetal cardiac output (CO) and downregulates fetal adenosine A(2A) receptor gene expression.	Caffeine	157-165	adenosine A2a receptor	Mus musculus	233-257
21976111-5	2012	In fact, in ATR-deficient or caffeine-treated cells UV light rather down-regulated the p21(WAF1/Cip1)  protein through SKP2-dependent ubiquitination and degradation via the proteasomal pathway.	Caffeine	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-90
21976111-5	2012	In fact, in ATR-deficient or caffeine-treated cells UV light rather down-regulated the p21(WAF1/Cip1)  protein through SKP2-dependent ubiquitination and degradation via the proteasomal pathway.	Caffeine	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-95
21976111-5	2012	In fact, in ATR-deficient or caffeine-treated cells UV light rather down-regulated the p21(WAF1/Cip1)  protein through SKP2-dependent ubiquitination and degradation via the proteasomal pathway.	Caffeine	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-100
21976111-5	2012	In fact, in ATR-deficient or caffeine-treated cells UV light rather down-regulated the p21(WAF1/Cip1)  protein through SKP2-dependent ubiquitination and degradation via the proteasomal pathway.	Caffeine	29-37	S-phase kinase associated protein 2	Homo sapiens	119-123
24764514-9	2012	Life span extension using caffeine displays epistatic interaction with two known longevity interventions: dietary restriction and reduced insulin signaling.	Caffeine	26-34	insulin	Homo sapiens	138-145
24764514-12	2012	Further, it may be important to consider caffeine consumption when developing clinical interventions, particularly those designed to mimic dietary restriction or modulate insulin/IGF-1-like signaling.	Caffeine	41-49	insulin like growth factor 1	Homo sapiens	179-184
22959965-1	2012	Caffeine and melatonin have been shown to protect the Swedish mutant amyloid precursor protein (APP(sw)) transgenic mouse model of Alzheimer"s disease from cognitive dysfunction.	Caffeine	0-8	amyloid beta (A4) precursor protein	Mus musculus	69-94
22981724-8	2012	CONCLUSION: Our results suggest that patients who want to use CYP1A2-metabolized drugs such as caffeine and theophylline should be advised of the potential herb-drug interaction, to reduce therapeutic failure or increased toxicity of conventional drug therapy.	Caffeine	95-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
22995397-0	2012	Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation.	Caffeine	0-8	insulin-like growth factor 1	Rattus norvegicus	101-106
22995397-5	2012	Maternal prenatal caffeine exposure was associated with decreased fetal femur lengths and inhibited of synthesis of extracellular matrices in fetal growth plates Moreover, caffeine exposure significantly increased the levels of fetal blood corticosterone and decreased IGF-1mRNA expression levels in the liver and growth plate.	Caffeine	18-26	insulin-like growth factor 1	Rattus norvegicus	269-274
22995397-5	2012	Maternal prenatal caffeine exposure was associated with decreased fetal femur lengths and inhibited of synthesis of extracellular matrices in fetal growth plates Moreover, caffeine exposure significantly increased the levels of fetal blood corticosterone and decreased IGF-1mRNA expression levels in the liver and growth plate.	Caffeine	172-180	insulin-like growth factor 1	Rattus norvegicus	269-274
22995397-7	2012	In addition, the results of chromatin immunoprecipitation assays indicated that caffeine exposure down-regulated histone methylation of fetal IGF-1 in the liver.	Caffeine	80-88	insulin-like growth factor 1	Rattus norvegicus	142-147
22995397-8	2012	These results suggest that prenatal caffeine exposure may inhibit fetal skeletal growth through a mechanism that is associated with increased fetal exposure to maternal glucocorticoids and results in lower IGF-1 signaling pathway activity.	Caffeine	36-44	insulin-like growth factor 1	Rattus norvegicus	206-211
22612345-8	2012	Selective treatment with an adenosine A(2A) receptor antagonist, but not an adenosine A(1) receptor antagonist, reproduced the altered fetal CO response to maternal hypoxia created by caffeine exposure.	Caffeine	184-192	adenosine A2a receptor	Mus musculus	28-52
22612345-9	2012	CONCLUSIONS:   Results suggest an additive negative effect of maternal caffeine on the fetal CV response to acute maternal hypoxia, potentially mediated via adenosine A(2A) receptor inhibition during primary cardiovascular morphogenesis.	Caffeine	71-79	adenosine A2a receptor	Mus musculus	157-181
22784666-6	2012	Conversely, RyR-mediated Ca2+ release induced by caffeine, was not observed in myoblasts, but triggered a large [Ca2+]c signal in myotubes.	Caffeine	49-57	ryanodine receptor 1	Homo sapiens	12-15
22725721-8	2012	RESULTS: The p-PBPK model predicted the PK changes of three model compounds (namely caffeine, metoprolol and midazolam) for CYP1A2, CYP2D6 and CYP3A4 during pregnancy within twofold of observed values.	Caffeine	84-92	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
22725721-8	2012	RESULTS: The p-PBPK model predicted the PK changes of three model compounds (namely caffeine, metoprolol and midazolam) for CYP1A2, CYP2D6 and CYP3A4 during pregnancy within twofold of observed values.	Caffeine	84-92	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	132-138
22725721-8	2012	RESULTS: The p-PBPK model predicted the PK changes of three model compounds (namely caffeine, metoprolol and midazolam) for CYP1A2, CYP2D6 and CYP3A4 during pregnancy within twofold of observed values.	Caffeine	84-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	143-149
22962011-4	2012	This effect was significantly reduced by a high concentration of ryanodine (100 muM) or chronic caffeine (5 mM) that blocked ryanodine receptor (RyR) but was insensitive to xestospongin C (10 muM), an inositol trisphosphate receptor antagonist.	Caffeine	96-104	ryanodine receptor 2	Rattus norvegicus	125-143
22962011-4	2012	This effect was significantly reduced by a high concentration of ryanodine (100 muM) or chronic caffeine (5 mM) that blocked ryanodine receptor (RyR) but was insensitive to xestospongin C (10 muM), an inositol trisphosphate receptor antagonist.	Caffeine	96-104	ryanodine receptor 2	Rattus norvegicus	145-148
22646289-7	2012	Conventional and decaffeinated coffee and caffeine intake significantly reduced serum levels of alanine aminotransferase (ALT) (p &lt; 0.001) and oxidized glutathione (p &lt; 0.05), fibrosis/inflammation scores (p &lt; 0.001), collagen volume fraction (p &lt; 0.01) and transforming growth factor beta-1 (TGF-beta1) protein expression (p &lt;= 0.001) in the liver from TAA-treated groups.	Caffeine	42-50	transforming growth factor, beta 1	Rattus norvegicus	270-303
22646289-7	2012	Conventional and decaffeinated coffee and caffeine intake significantly reduced serum levels of alanine aminotransferase (ALT) (p &lt; 0.001) and oxidized glutathione (p &lt; 0.05), fibrosis/inflammation scores (p &lt; 0.001), collagen volume fraction (p &lt; 0.01) and transforming growth factor beta-1 (TGF-beta1) protein expression (p &lt;= 0.001) in the liver from TAA-treated groups.	Caffeine	42-50	transforming growth factor, beta 1	Rattus norvegicus	305-314
22948152-5	2012	The RyR agonist caffeine evoked Ca(2+) release from the intracellular store in activated T cells but not in resting T cells, indicating that RyR are functionally up-regulated in activated T cells compared with resting T cells.	Caffeine	16-24	ryanodine receptor 1	Homo sapiens	4-7
21876539-6	2012	CYP1A1 was found to be downregulated in lymphoblastoid cell lines treated with caffeine.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
21876539-7	2012	CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine.	Caffeine	164-172	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
21876539-7	2012	CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine.	Caffeine	164-172	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	116-122
22959462-6	2012	Further, the hippocampal mineralocorticoid receptor (MR) expression in caffeine group was initially decreased and subsequently increased after birth.	Caffeine	71-79	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	25-51
22959462-6	2012	Further, the hippocampal mineralocorticoid receptor (MR) expression in caffeine group was initially decreased and subsequently increased after birth.	Caffeine	71-79	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	53-55
22948152-5	2012	The RyR agonist caffeine evoked Ca(2+) release from the intracellular store in activated T cells but not in resting T cells, indicating that RyR are functionally up-regulated in activated T cells compared with resting T cells.	Caffeine	16-24	ryanodine receptor 1	Homo sapiens	141-144
23035103-7	2012	This reoxygenation-dependent activation of caspase 1 was prevented by broad-spectrum adenosine receptor (AR) antagonism with caffeine and by targeted A1/A2A AR antagonism with 8-cyclopentyl-1,3-dipropylxanthine plus 3,7-dimethyl-1-propargylxanthine.	Caffeine	125-133	caspase 1	Mus musculus	43-52
22842488-5	2012	STIM1 subplasmalemmal translocation and clustering can be induced by ER Ca(2+) store depletion with thapsigargin (TG), G-protein-coupled receptor activator trypsin and ryanodine receptor (RyR) agonists caffeine and 4-chloro-3-ethylphenol (4-CEP) in the HEK293 cells stably transfected with STIM1-EYFP.	Caffeine	202-210	stromal interaction molecule 1	Homo sapiens	0-5
22842488-5	2012	STIM1 subplasmalemmal translocation and clustering can be induced by ER Ca(2+) store depletion with thapsigargin (TG), G-protein-coupled receptor activator trypsin and ryanodine receptor (RyR) agonists caffeine and 4-chloro-3-ethylphenol (4-CEP) in the HEK293 cells stably transfected with STIM1-EYFP.	Caffeine	202-210	ryanodine receptor 1	Homo sapiens	188-191
22948892-3	2012	CYP1A2 activity was determined using the 4 h paraxanthine/caffeine saliva concentration ratio following a 100-mg oral dose of caffeine in healthy individuals of South Asian (n = 166) and European (n = 166) ancestry.	Caffeine	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
22859494-8	2012	In vivo caffeine reduced DDR activation in vascular and nonvascular tissues, reduced reactive nitrogen species and serum levels of the DNA adduct 8-oxo-guanine, and inhibited atherogenesis in fat-fed ApoE(-/-) mice.	Caffeine	8-16	apolipoprotein E	Mus musculus	200-204
22859494-10	2012	CONCLUSIONS: The Methyl Xanthine caffeine inhibits the DNA damage response in vitro and in vivo, regulates both cell proliferation and apoptosis after DNA damage, inhibits reactive species, and reduces atherogenesis in ApoE(-/-) mice.	Caffeine	33-41	apolipoprotein E	Mus musculus	219-223
22948892-3	2012	CYP1A2 activity was determined using the 4 h paraxanthine/caffeine saliva concentration ratio following a 100-mg oral dose of caffeine in healthy individuals of South Asian (n = 166) and European (n = 166) ancestry.	Caffeine	126-134	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
22771386-8	2012	An increase in c-Fos-positive labeled cells was found in the caffeine-treated group at P5-P6 within the same areas described above, with the most clear-cut increase seen in the arcuate nucleus.	Caffeine	61-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
21721019-4	2012	However, SULT regulation by caffeine has not been reported.	Caffeine	28-36	carbohydrate sulfotransferase 10	Rattus norvegicus	9-13
22771369-8	2012	Our results suggest that patients receiving CYP1A2-metabolized drugs, such as caffeine and theophylline, should be advised of the potential herb-drug interaction to reduce the risk of therapeutic failure or increased toxicity of conventional drug therapy.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
21721019-6	2012	Western blot and real-time RT-PCR were used to investigate the changes in SULT protein and mRNA expression following the caffeine treatment.	Caffeine	121-129	carbohydrate sulfotransferase 10	Rattus norvegicus	74-78
21721019-7	2012	Caffeine induced both rat aryl sulfotransferase (rSULT1A1, AST-IV) and rat hydroxysteroid sulfotransferase (rSULT2A1, STa) in the liver and intestine of female rats in a dose-dependent manner.	Caffeine	0-8	sulfotransferase family 1A member 1	Rattus norvegicus	49-57
22313413-5	2012	Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c.	Caffeine	57-65	neuropilin 1a	Danio rerio	108-113
21721019-7	2012	Caffeine induced both rat aryl sulfotransferase (rSULT1A1, AST-IV) and rat hydroxysteroid sulfotransferase (rSULT2A1, STa) in the liver and intestine of female rats in a dose-dependent manner.	Caffeine	0-8	sulfotransferase family 1A member 1	Rattus norvegicus	59-65
21721019-7	2012	Caffeine induced both rat aryl sulfotransferase (rSULT1A1, AST-IV) and rat hydroxysteroid sulfotransferase (rSULT2A1, STa) in the liver and intestine of female rats in a dose-dependent manner.	Caffeine	0-8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	75-106
22313413-5	2012	Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c.	Caffeine	57-65	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa	Danio rerio	145-152
21721019-7	2012	Caffeine induced both rat aryl sulfotransferase (rSULT1A1, AST-IV) and rat hydroxysteroid sulfotransferase (rSULT2A1, STa) in the liver and intestine of female rats in a dose-dependent manner.	Caffeine	0-8	sulfotransferase family 2A member 1	Rattus norvegicus	108-116
22313413-5	2012	Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c.	Caffeine	57-65	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	Danio rerio	157-163
21721019-8	2012	Caffeine induction of rSULT1A1 and rSULT2A1 in the female rat intestine was much stronger than that in the liver.	Caffeine	0-8	sulfotransferase family 1A member 1	Rattus norvegicus	22-30
21721019-8	2012	Caffeine induction of rSULT1A1 and rSULT2A1 in the female rat intestine was much stronger than that in the liver.	Caffeine	0-8	sulfotransferase family 2A member 1	Rattus norvegicus	35-43
21721019-9	2012	Although caffeine induced rSULT1A1 significantly in the male rat liver, it did not significantly induce rSULT2A1.	Caffeine	9-17	sulfotransferase family 1A member 1	Rattus norvegicus	26-34
21721019-10	2012	In male rat intestine, caffeine significantly induced rSULT2A1.	Caffeine	23-31	sulfotransferase family 2A member 1	Rattus norvegicus	54-62
22763023-2	2012	We examined potential interactions of smoking and caffeine intake with 10 genome-wide association studies single nucleotide polymorphisms (SNPs) at or near the SNCA, MAPT, LRRK2, and HLA loci among 584 PD patients and 1571 controls.	Caffeine	50-58	synuclein alpha	Homo sapiens	160-164
22593008-7	2012	Indeed, 7-d-induced G2/M arrest and apoptosis were antagonized by ATM/ATR signaling inhibitor, Caffeine, which suggested that ATM/ATR signaling was activated by 7-d treatment.	Caffeine	95-103	ATM serine/threonine kinase	Homo sapiens	66-69
22593008-7	2012	Indeed, 7-d-induced G2/M arrest and apoptosis were antagonized by ATM/ATR signaling inhibitor, Caffeine, which suggested that ATM/ATR signaling was activated by 7-d treatment.	Caffeine	95-103	ATM serine/threonine kinase	Homo sapiens	126-129
22763023-6	2012	However, with a combined smoking and caffeine intake exposure, we found a significant interaction with rs2896905 at SLC2A13, near LRRK2 (p uncorrected = 0.0008).	Caffeine	37-45	solute carrier family 2 member 13	Homo sapiens	116-123
22763023-6	2012	However, with a combined smoking and caffeine intake exposure, we found a significant interaction with rs2896905 at SLC2A13, near LRRK2 (p uncorrected = 0.0008).	Caffeine	37-45	leucine rich repeat kinase 2	Homo sapiens	130-135
22841599-1	2012	Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods.	Caffeine	75-83	amine oxidase, copper containing 3	Rattus norvegicus	103-140
22841599-0	2012	Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase.	Caffeine	33-41	amine oxidase, copper containing 3	Rattus norvegicus	79-116
22841599-1	2012	Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods.	Caffeine	75-83	amine oxidase, copper containing 3	Rattus norvegicus	142-146
22841599-3	2012	The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine.	Caffeine	117-125	amine oxidase, copper containing 3	Rattus norvegicus	59-63
22841599-4	2012	As the concentration of caffeine increased, the SSAO activity decreased.	Caffeine	24-32	amine oxidase, copper containing 3	Rattus norvegicus	48-52
22841599-6	2012	We presume that caffeine may treat with SSAO activity associated diseases.	Caffeine	16-24	amine oxidase, copper containing 3	Rattus norvegicus	40-44
22993301-0	2012	Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	63-66
22834763-0	2012	CAF@ZIF-8: one-step encapsulation of caffeine in MOF.	Caffeine	37-45	lysine acetyltransferase 2B	Homo sapiens	0-9
22926241-9	2012	Importantly, nitric oxide synthase (NOS) inhibitor (L-NAME) suppressed caffeine-induced mtDNA biogenesis, whereas NO donor (DETA-NO) increased mtDNA content.	Caffeine	71-79	nitric oxide synthase 2	Homo sapiens	13-34
22777004-6	2012	METHODS AND RESULTS: Fruit fly heart tubes deficient of the Drosophila Mfn ortholog MARF had increased contraction-associated and caffeine-sensitive Ca(2+) release, suggesting a role for Mfn in SR Ca(2+) handling.	Caffeine	130-138	Mitochondrial assembly regulatory factor	Drosophila melanogaster	71-74
22777004-6	2012	METHODS AND RESULTS: Fruit fly heart tubes deficient of the Drosophila Mfn ortholog MARF had increased contraction-associated and caffeine-sensitive Ca(2+) release, suggesting a role for Mfn in SR Ca(2+) handling.	Caffeine	130-138	Mitochondrial assembly regulatory factor	Drosophila melanogaster	84-88
23882149-1	2012	PURPOSE: This work investigated if treatment with caffeine or 2,4-dinitrophenol (DNP) induce expression of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1alpha) and increase both mitochondrial biosynthesis and metabolism in skeletal muscle.	Caffeine	50-58	PPARG coactivator 1 alpha	Homo sapiens	171-181
23882149-6	2012	RESULTS: Treatment with either caffeine or DNP induced PGC-1alpha RNA and protein as well as mitochondrial content compared with control.	Caffeine	31-39	PPARG coactivator 1 alpha	Homo sapiens	55-65
23882149-9	2012	CONCLUSION: This work identified that both caffeine and DNP significantly induce PGC-1alpha, and increase both metabolism and mitochondrial content in skeletal muscle.	Caffeine	43-51	PPARG coactivator 1 alpha	Homo sapiens	81-91
22854411-0	2012	Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption.	Caffeine	90-98	aryl hydrocarbon receptor	Homo sapiens	42-45
22854411-0	2012	Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
22854411-0	2012	Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
22854411-1	2012	BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.	Caffeine	269-277	aryl hydrocarbon receptor	Homo sapiens	149-174
22854411-1	2012	BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.	Caffeine	269-277	aryl hydrocarbon receptor	Homo sapiens	176-179
22854411-1	2012	BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.	Caffeine	269-277	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	185-212
22854411-1	2012	BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.	Caffeine	269-277	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	214-220
22854411-1	2012	BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.	Caffeine	269-277	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	221-227
22854411-10	2012	CONCLUSION: Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers.	Caffeine	99-107	aryl hydrocarbon receptor	Homo sapiens	73-76
22854411-10	2012	CONCLUSION: Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers.	Caffeine	99-107	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-87
22854411-10	2012	CONCLUSION: Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers.	Caffeine	99-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94
22993301-0	2012	Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	67-71
22993301-0	2012	Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways.	Caffeine	0-8	ribosomal protein S6 kinase B1	Homo sapiens	72-75
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	phosphatase and tensin homolog	Homo sapiens	123-127
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	130-133
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	135-161
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	163-166
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	caspase 3	Homo sapiens	169-178
22993301-2	2012	Caffeine affects tumour cells through various pathways, including phosphatase and tensin homolog deleted on chromosome 10 (PTEN), AKT, Bcl-2-associated X protein (BAX), caspase-3 and p53, and has therefore been indicated as being useful for the treatment of malignant tumours.	Caffeine	0-8	tumor protein p53	Homo sapiens	183-186
22993301-4	2012	Caffeine inhibited proliferation of HOS cells and suppressed NF-kappaB, AKT, mTOR/S6K and ERK activities.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	72-75
22993301-4	2012	Caffeine inhibited proliferation of HOS cells and suppressed NF-kappaB, AKT, mTOR/S6K and ERK activities.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	77-81
22993301-4	2012	Caffeine inhibited proliferation of HOS cells and suppressed NF-kappaB, AKT, mTOR/S6K and ERK activities.	Caffeine	0-8	ribosomal protein S6 kinase B1	Homo sapiens	82-85
22993301-4	2012	Caffeine inhibited proliferation of HOS cells and suppressed NF-kappaB, AKT, mTOR/S6K and ERK activities.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	90-93
22828439-3	2012	Increased phosphorylation levels of Chk2 and H2AX were observed and were reversed by the DNA damage inhibitor caffeine in calactin-treated cells.	Caffeine	110-118	checkpoint kinase 2	Homo sapiens	36-40
22851680-0	2012	Caffeine inhibits EGF-stimulated trophoblast cell motility through the inhibition of mTORC2 and Akt.	Caffeine	0-8	CREB regulated transcription coactivator 2	Mus musculus	85-91
22851680-0	2012	Caffeine inhibits EGF-stimulated trophoblast cell motility through the inhibition of mTORC2 and Akt.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	96-99
22851680-6	2012	The influence of caffeine and cAMP on EGF-stimulated intracellular signaling pathways leading to the activation of Akt were investigated by Western blot analysis.	Caffeine	17-25	AKT serine/threonine kinase 1	Homo sapiens	115-118
22851680-10	2012	Further investigation indicated a role for mammalian target of rapamycin complex 2 (mTORC2) as a target for the inhibitory effect of caffeine.	Caffeine	133-141	CREB regulated transcription coactivator 2	Mus musculus	84-90
22828439-3	2012	Increased phosphorylation levels of Chk2 and H2AX were observed and were reversed by the DNA damage inhibitor caffeine in calactin-treated cells.	Caffeine	110-118	H2A.X variant histone	Homo sapiens	45-49
22710994-4	2012	Increased concentrations of uncoupling protein-2 (UCP-2) also indicated a thermogenic activity of caffeine.	Caffeine	98-106	uncoupling protein 2	Homo sapiens	28-48
22710994-4	2012	Increased concentrations of uncoupling protein-2 (UCP-2) also indicated a thermogenic activity of caffeine.	Caffeine	98-106	uncoupling protein 2	Homo sapiens	50-55
22587992-5	2012	Similar decreases were observed in the Ca(2+) transient and the Ca(2+) decay rate slowed in response to caffeine in PKCbeta(II)-expressing myocytes.	Caffeine	104-112	protein kinase C beta	Homo sapiens	116-123
22753029-3	2012	Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhibitor caffeine--inhibiting ATM and ATR amongst other kinases--is explained by inability to activate the CHK1 kinase to stabilize replicative structures.	Caffeine	103-111	ATR serine/threonine kinase	Homo sapiens	132-135
22753029-3	2012	Therefore, we wanted to test if the increased UV sensitivity caused by the unspecific kinase inhibitor caffeine--inhibiting ATM and ATR amongst other kinases--is explained by inability to activate the CHK1 kinase to stabilize replicative structures.	Caffeine	103-111	checkpoint kinase 1	Homo sapiens	201-205
21885687-1	2012	In this study, the authors developed a phenotyping method for CYP1A2, 2C9, 2C19, 2D6, and 3A4 using a cocktail of 100 mg caffeine, 125 mg tolbutamide, 20 mg omeprazole, 30 mg dextromethorphan, and 2 mg midazolam.	Caffeine	121-129	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
22648710-1	2012	BACKGROUND: The enzyme CYP1A2 (cytochrome 1A2) is involved in the metabolism of certain drugs and caffeine, and its activity can be influenced by factors such as sex, age, and smoking.	Caffeine	98-106	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	23-29
22399050-0	2012	Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.	Caffeine	16-24	neuropeptide S receptor 1	Homo sapiens	68-91
22399050-1	2012	RATIONALE/OBJECTIVES: Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies.	Caffeine	114-122	adenosine A2a receptor	Homo sapiens	81-103
22399050-2	2012	Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system has been suggested with administration of the adenosine A2A receptor antagonist caffeine downregulating NPS levels (Lage et al., 2006) and attenuating the stimulatory effects of NPS in rodents (Boeck et al., 2010).	Caffeine	166-174	neuropeptide S	Homo sapiens	42-56
22399050-2	2012	Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system has been suggested with administration of the adenosine A2A receptor antagonist caffeine downregulating NPS levels (Lage et al., 2006) and attenuating the stimulatory effects of NPS in rodents (Boeck et al., 2010).	Caffeine	166-174	adenosine A2a receptor	Homo sapiens	132-154
22705191-8	2012	Using molecular docking experiments, this study also proposes possible binding orientations of selected caffeine derivatives in the active sites of MAO-A and -B.	Caffeine	104-112	monoamine oxidase A	Homo sapiens	148-160
22492992-0	2012	Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
22492992-3	2012	CYP1A2 metabolizes caffeine and is induced by smoking.	Caffeine	19-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
22492992-12	2012	In non-smokers, the CYP1A2 variants were associated with higher reported caffeine intake, which in turn was associated with lower odds of hypertension and lower BP (P = 0.01).	Caffeine	73-81	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
22492992-14	2012	The associations of CYP1A2 variants with BP were modified by reported caffeine intake.	Caffeine	70-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
22492992-15	2012	These observational and quasi-experimental results strongly support a causal role of CYP1A2 in BP control via caffeine intake.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	85-91
22648710-1	2012	BACKGROUND: The enzyme CYP1A2 (cytochrome 1A2) is involved in the metabolism of certain drugs and caffeine, and its activity can be influenced by factors such as sex, age, and smoking.	Caffeine	98-106	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-45
22582116-3	2012	In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release.	Caffeine	96-104	ryanodine receptor 2	Rattus norvegicus	209-212
22583948-8	2012	Meanwhile, the expressions of insulin-like growth factor 1 (IGF-1), IGF-1 receptor and insulin receptor were decreased, while the expressions of adiponectin receptor 2, leptin receptors and AMP-activated protein kinase alpha2 were increased after caffeine treatment.	Caffeine	247-255	adiponectin receptor 2	Rattus norvegicus	145-167
22583948-9	2012	Prenatal caffeine ingestion characteristically change the fetal metabonome, which is probably attributed to the alterations of glucose and lipid metabolic pathways induced by increased circulatory GC, activated GC metabolism and enhanced GR expression in peripheral metabolic tissues.	Caffeine	9-17	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	238-240
22582116-3	2012	In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release.	Caffeine	96-104	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	214-220
22582116-5	2012	The RyR antagonist ryanodine (10 muM) blocked Ca(2+) release to caffeine and hypoxia but not norepinephrine.	Caffeine	64-72	ryanodine receptor 2	Rattus norvegicus	4-7
22492205-4	2012	The deletion of OST3 in the rot1-1 mutant causes a temperature sensitive phenotype as well as sensitivity toward compounds interfering with cell wall biogenesis such as Calcofluor White, caffeine, Congo Red and hygromycin B, whereas the deletion of OST6, a functional homolog of OST3, has no effect.	Caffeine	187-195	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Saccharomyces cerevisiae S288C	16-20
22492205-4	2012	The deletion of OST3 in the rot1-1 mutant causes a temperature sensitive phenotype as well as sensitivity toward compounds interfering with cell wall biogenesis such as Calcofluor White, caffeine, Congo Red and hygromycin B, whereas the deletion of OST6, a functional homolog of OST3, has no effect.	Caffeine	187-195	Rot1p	Saccharomyces cerevisiae S288C	28-34
22754033-0	2012	"No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype.	Caffeine	47-55	adenosine A2a receptor	Homo sapiens	79-86
22554278-0	2012	Measurement of CYP1A2 activity: a focus on caffeine as a probe.	Caffeine	43-51	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-21
22265862-3	2012	When hepatoma cell lines HepG2 and PLC/PRF/5 were treated with sorafenib plus ATM small inhibitory RNAs, ATM inhibitor KU55933 or caffeine, Akt signaling was suppressed and the cytotoxic effects were significantly potentiated.	Caffeine	130-138	AKT serine/threonine kinase 1	Homo sapiens	140-143
22293778-5	2012	Immunohistochemical and western blot analysis with proliferating cell nuclear antigen and glutathione S-transferase-P antibodies also showed that expression levels of these hepato-carcinogenic markers were more efficiently reduced by treatment with caffeine than curcumin.	Caffeine	249-257	glutathione S-transferase pi 1	Rattus norvegicus	90-117
22554278-4	2012	Caffeine is the only currently accepted probe to conduct in vivo phenotyping of CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
22554278-5	2012	Despite the number of proposed matrices (biological fluid containing the drug and/or metabolite/s of interest) and metrics (mathematical formula relating the drug and/or metabolite/s to enzyme activity) proposed to measure CYP1A2 activity using caffeine, many of these are compromised by factors related to the specific metabolic pathway studied or pharmacokinetic characteristics of caffeine and its metabolites.	Caffeine	245-253	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	223-229
23167901-0	2012	Caffeine induces CYP1A2 expression in rat hepatocytes but not in human hepatocytes.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	17-23
23167901-3	2012	Results from rat studies have shown that caffeine is an inducer of CYP1A2, the enzyme responsible for caffeine"s metabolism.	Caffeine	41-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	67-73
23167901-3	2012	Results from rat studies have shown that caffeine is an inducer of CYP1A2, the enzyme responsible for caffeine"s metabolism.	Caffeine	102-110	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	67-73
23167901-4	2012	This suggests that CYP1A2 induction by caffeine may be in part responsible for caffeine tolerance.	Caffeine	39-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	19-25
23167901-4	2012	This suggests that CYP1A2 induction by caffeine may be in part responsible for caffeine tolerance.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	19-25
23167901-5	2012	However, whether caffeine induces CYP1A2 expression in humans remains unknown.	Caffeine	17-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	34-40
23167901-8	2012	On the other hand, caffeine enhanced CYP1A2 expression by 9-fold in rat hepatocytes.	Caffeine	19-27	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	37-43
22449533-7	2012	Gene expression of TPH2 was also increased by caffeine treatment.	Caffeine	46-54	tryptophan hydroxylase 2	Gallus gallus	19-23
22849705-0	2012	Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers.	Caffeine	49-57	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-19
22849705-1	2012	Phenotyping of cytochrome P450 2A6 (CYP2A6) was determined by assessing urinary caffeine metabolites in a Japanese population with a high frequency of CYP2A6 whole-gene deletion (CYP2A6*4).	Caffeine	80-88	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	15-34
22849705-1	2012	Phenotyping of cytochrome P450 2A6 (CYP2A6) was determined by assessing urinary caffeine metabolites in a Japanese population with a high frequency of CYP2A6 whole-gene deletion (CYP2A6*4).	Caffeine	80-88	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	36-42
22849705-3	2012	Low 17U/1X ratios were observed in accumulated overnight urine samples of subjects genotyped as CYP2A6*4/*4 after caffeine treatment.	Caffeine	114-122	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	96-102
22849705-6	2012	The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine.	Caffeine	175-183	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	42-48
22849705-6	2012	The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine.	Caffeine	175-183	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	74-80
22849705-6	2012	The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine.	Caffeine	253-261	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	42-48
22849705-6	2012	The present results suggest that impaired CYP2A6 function associated with CYP2A6 *4/ *4 could be determined using the 17U/1X ratios in spot urine samples under normal dietary caffeine consumption in Japanese non-smokers, without the need for additional caffeine administration or prior abstention from caffeine.	Caffeine	253-261	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	42-48
24761269-2	2012	Little is known about the A2A adenosine receptor in the maternal brain, and whether caffeine consumption throughout gestational period modifies GFAP and adenosine receptor density in specific brain areas.	Caffeine	84-92	glial fibrillary acidic protein	Rattus norvegicus	144-148
24761269-5	2012	RESULTS: We show a consistent and highly significant reduction of GFAP-ir in caffeine-treated pregnant rats in most of the areas analyzed.	Caffeine	77-85	glial fibrillary acidic protein	Rattus norvegicus	66-70
22463611-8	2012	Instead, in WT, caffeine increased palmitate transport (+55%) and the translocation of fatty acid transporters CD36, FABPpm, FATP1 and FATP4 (26-70%) to the sarcolemma.	Caffeine	16-24	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	117-123
22463611-8	2012	Instead, in WT, caffeine increased palmitate transport (+55%) and the translocation of fatty acid transporters CD36, FABPpm, FATP1 and FATP4 (26-70%) to the sarcolemma.	Caffeine	16-24	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	125-130
22463611-9	2012	In CD36-KO mice, caffeine-stimulated FABPpm, and FATP1 and 4 translocations were normal, but palmitate transport was blunted (-70%), comparable to the reductions in muscle palmitate oxidation.	Caffeine	17-25	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	37-43
22483397-2	2012	CYP isoform specific substrates and their metabolites of CYP1A2 (caffeine), CYP2C9 (losartan), CYP2C19 (omeprazole), CYP2D6 (dextromethorphan) and CYP3A (midazolam) were all simultaneously analyzed using LC-MS/MS after administration of a mixture of five drugs (i.e., a "cocktail approach") to healthy volunteers.	Caffeine	65-73	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
22564307-4	2012	In a previous study, we showed that alanine mutations of the DDK phosphorylation sites at S164 and S170 in Saccharomyces cerevisiae Mcm2 result in sensitivity to caffeine and methyl methanesulfonate (MMS) leading us to suggest that DDK phosphorylation of Mcm2 is required in response to replicative stress.	Caffeine	162-170	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	132-136
22564307-4	2012	In a previous study, we showed that alanine mutations of the DDK phosphorylation sites at S164 and S170 in Saccharomyces cerevisiae Mcm2 result in sensitivity to caffeine and methyl methanesulfonate (MMS) leading us to suggest that DDK phosphorylation of Mcm2 is required in response to replicative stress.	Caffeine	162-170	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	255-259
22483397-2	2012	CYP isoform specific substrates and their metabolites of CYP1A2 (caffeine), CYP2C9 (losartan), CYP2C19 (omeprazole), CYP2D6 (dextromethorphan) and CYP3A (midazolam) were all simultaneously analyzed using LC-MS/MS after administration of a mixture of five drugs (i.e., a "cocktail approach") to healthy volunteers.	Caffeine	65-73	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
22336631-0	2012	Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	69-91
22319196-7	2012	4-Methyl-N-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide, menthol, and caffeine displayed species-specific differential pharmacology at TRPA1.	Caffeine	86-94	transient receptor potential cation channel subfamily A member 1	Homo sapiens	151-156
22343349-4	2012	The expression of CaPPZ1 in ppz1 S. cerevisiae and pzh1 Schizosaccharomyces pombe cells partially rescued the salt and caffeine phenotypes of the deletion mutants.	Caffeine	119-127	salt homeostasis regulator	Saccharomyces cerevisiae S288C	28-32
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	Caffeine	220-228	endogenous retrovirus group K member 15	Homo sapiens	186-190
22437887-8	2012	Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-alpha.	Caffeine	37-45	coagulation factor III, tissue factor	Homo sapiens	74-76
22437887-8	2012	Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-alpha.	Caffeine	172-180	coagulation factor III, tissue factor	Homo sapiens	74-76
22437887-8	2012	Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-alpha.	Caffeine	172-180	coagulation factor III, tissue factor	Homo sapiens	136-138
22437887-8	2012	Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-alpha.	Caffeine	172-180	tumor necrosis factor	Homo sapiens	200-209
22437887-9	2012	In conclusion, caffeine enhances TNF-alpha-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling.	Caffeine	15-23	tumor necrosis factor	Homo sapiens	33-42
22437887-9	2012	In conclusion, caffeine enhances TNF-alpha-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling.	Caffeine	15-23	coagulation factor III, tissue factor	Homo sapiens	63-65
22437887-0	2012	Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition.	Caffeine	0-8	coagulation factor III, tissue factor	Homo sapiens	29-42
22437887-0	2012	Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition.	Caffeine	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	58-87
22437887-3	2012	Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro.	Caffeine	60-68	coagulation factor III, tissue factor	Homo sapiens	84-86
22437887-4	2012	Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-alpha or thrombin.	Caffeine	0-8	coagulation factor III, tissue factor	Homo sapiens	44-46
22437887-4	2012	Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-alpha or thrombin.	Caffeine	0-8	tumor necrosis factor	Homo sapiens	128-162
22437887-4	2012	Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-alpha or thrombin.	Caffeine	0-8	coagulation factor II, thrombin	Homo sapiens	166-174
22437887-5	2012	Caffeine inhibited phosphatidylinositol 3-kinase (PI3K) activity and this effect was comparable to that of the known PI3K inhibitor LY294002.	Caffeine	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	19-48
22336631-0	2012	Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	101-120
22336631-2	2012	The secondary aim was to investigate the relation between caffeine-induced changes in tear volume and polymorphisms in ADORA2A and CYP1A2.	Caffeine	58-66	adenosine A2a receptor	Homo sapiens	119-126
22336631-2	2012	The secondary aim was to investigate the relation between caffeine-induced changes in tear volume and polymorphisms in ADORA2A and CYP1A2.	Caffeine	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	131-137
22336631-14	2012	CONCLUSIONS: Caffeine intake increases tear volume and polymorphisms within ADORA2A, and CYP1A2 is associated with the tear increase after caffeine intake.	Caffeine	13-21	adenosine A2a receptor	Homo sapiens	76-83
22336631-14	2012	CONCLUSIONS: Caffeine intake increases tear volume and polymorphisms within ADORA2A, and CYP1A2 is associated with the tear increase after caffeine intake.	Caffeine	139-147	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	89-95
22187152-5	2012	Moreover, we show that extracts containing reduced levels of RPA accumulate ssDNA and induce spontaneous, caffeine-sensitive, Chk1 phosphorylation in S-phase.	Caffeine	106-114	replication protein A1 S homeolog	Xenopus laevis	61-64
22243401-0	2012	Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents.	Caffeine	94-102	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	8-11
22243401-8	2012	Abnormal placental structures and decreased maternal plasma prolactin concentrations were observed following 180 mg/kg per day caffeine treatment, which resulted in increases in renin-angiotensin system (RAS) activity, including maternal plasma AngII concentrations and placental AT(1B)  and AT(2)  receptor expression, and Bax and p53 expression, but decreases in placental Bcl-2 expression.	Caffeine	127-135	angiotensinogen	Rattus norvegicus	245-250
22243401-8	2012	Abnormal placental structures and decreased maternal plasma prolactin concentrations were observed following 180 mg/kg per day caffeine treatment, which resulted in increases in renin-angiotensin system (RAS) activity, including maternal plasma AngII concentrations and placental AT(1B)  and AT(2)  receptor expression, and Bax and p53 expression, but decreases in placental Bcl-2 expression.	Caffeine	127-135	angiotensin II receptor, type 1b	Rattus norvegicus	280-285
22243401-8	2012	Abnormal placental structures and decreased maternal plasma prolactin concentrations were observed following 180 mg/kg per day caffeine treatment, which resulted in increases in renin-angiotensin system (RAS) activity, including maternal plasma AngII concentrations and placental AT(1B)  and AT(2)  receptor expression, and Bax and p53 expression, but decreases in placental Bcl-2 expression.	Caffeine	127-135	BCL2 associated X, apoptosis regulator	Rattus norvegicus	324-327
22243401-8	2012	Abnormal placental structures and decreased maternal plasma prolactin concentrations were observed following 180 mg/kg per day caffeine treatment, which resulted in increases in renin-angiotensin system (RAS) activity, including maternal plasma AngII concentrations and placental AT(1B)  and AT(2)  receptor expression, and Bax and p53 expression, but decreases in placental Bcl-2 expression.	Caffeine	127-135	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	332-335
22243401-8	2012	Abnormal placental structures and decreased maternal plasma prolactin concentrations were observed following 180 mg/kg per day caffeine treatment, which resulted in increases in renin-angiotensin system (RAS) activity, including maternal plasma AngII concentrations and placental AT(1B)  and AT(2)  receptor expression, and Bax and p53 expression, but decreases in placental Bcl-2 expression.	Caffeine	127-135	BCL2, apoptosis regulator	Rattus norvegicus	375-380
22243401-9	2012	On the basis of the results of the present study, it appears that caffeine ingestion has detrimental effects on the reproductive system and fetal development in rodents that are associated with chronic activation of the maternal and placental RAS, and induction of p53-dependent placental apoptosis.	Caffeine	66-74	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	265-268
22187152-5	2012	Moreover, we show that extracts containing reduced levels of RPA accumulate ssDNA and induce spontaneous, caffeine-sensitive, Chk1 phosphorylation in S-phase.	Caffeine	106-114	checkpoint kinase 1 S homeolog	Xenopus laevis	126-130
21967278-8	2012	Co-administration of caffeine with MDMA increased p-CREB, p-DARPP-32 and c-fos expression when compared with either treatment alone.	Caffeine	21-29	cAMP responsive element binding protein 1	Rattus norvegicus	52-56
22442089-4	2012	In line with these findings, two-photon calcium imaging experiments showed that the potentiation of RyR-mediated calcium release from internal stores by caffeine was absent in LMO4 KO neurons.	Caffeine	153-161	ryanodine receptor 1, skeletal muscle	Mus musculus	100-103
22404431-1	2012	This study investigated the effect of caffeine ingestion on antigen-stimulated T- (CD4(+) and CD8(+) ) and natural killer (NK)- (CD3(-) CD56(+) ) cell activation after prolonged, strenuous cycling.	Caffeine	38-46	CD4 molecule	Homo sapiens	83-86
22404431-1	2012	This study investigated the effect of caffeine ingestion on antigen-stimulated T- (CD4(+) and CD8(+) ) and natural killer (NK)- (CD3(-) CD56(+) ) cell activation after prolonged, strenuous cycling.	Caffeine	38-46	CD8a molecule	Homo sapiens	94-97
22404431-5	2012	At 1 h post-exercise the number of antigen-stimulated CD4(+) cells expressing CD69 decreased on CAF compared with PLA [15 (17) x 10(6) vs 23 (22) x 10(6) cells/L, P&lt;0.05].	Caffeine	96-99	CD4 molecule	Homo sapiens	54-57
22404431-5	2012	At 1 h post-exercise the number of antigen-stimulated CD4(+) cells expressing CD69 decreased on CAF compared with PLA [15 (17) x 10(6) vs 23 (22) x 10(6) cells/L, P&lt;0.05].	Caffeine	96-99	CD69 molecule	Homo sapiens	78-82
22404431-6	2012	In addition, the geometric mean fluorescence intensity (GMFI) of CD69 expression on antigen-stimulated CD8(+) cells decreased on CAF compared with PLA 1 h post-exercise [78 (10)% vs 102 (24)%, P&lt;0.05].	Caffeine	129-132	CD69 molecule	Homo sapiens	65-69
22404431-6	2012	In addition, the geometric mean fluorescence intensity (GMFI) of CD69 expression on antigen-stimulated CD8(+) cells decreased on CAF compared with PLA 1 h post-exercise [78 (10)% vs 102 (24)%, P&lt;0.05].	Caffeine	129-132	CD8a molecule	Homo sapiens	103-106
22404431-7	2012	At the same time-point GMFI of CD69 expression on antigen-stimulated CD3(-) CD56(+) cells was increased on CAF compared with PLA [103 (9)% vs 87 (8)%, P&lt;0.05].	Caffeine	107-110	CD69 molecule	Homo sapiens	31-35
22404431-7	2012	At the same time-point GMFI of CD69 expression on antigen-stimulated CD3(-) CD56(+) cells was increased on CAF compared with PLA [103 (9)% vs 87 (8)%, P&lt;0.05].	Caffeine	107-110	neural cell adhesion molecule 1	Homo sapiens	76-80
22404431-8	2012	These findings suggest that caffeine reduces antigen-stimulated CD69 expression on T cells while at the same time increases NK-cell activation 1 h after intensive cycling.	Caffeine	28-36	CD69 molecule	Homo sapiens	64-68
22445487-6	2012	Rapamycin and caffeine also induce Rho1 activation.	Caffeine	14-22	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	35-39
22420682-0	2012	The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine.	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	19-25
22420682-3	2012	A (C/A) single nucleotide polymorphism at intron 1 of the cytochrome P450 (CYP1A2) gene influences caffeine metabolism and clinical outcomes from caffeine ingestion.	Caffeine	99-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81
22420682-3	2012	A (C/A) single nucleotide polymorphism at intron 1 of the cytochrome P450 (CYP1A2) gene influences caffeine metabolism and clinical outcomes from caffeine ingestion.	Caffeine	146-154	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81
21967278-8	2012	Co-administration of caffeine with MDMA increased p-CREB, p-DARPP-32 and c-fos expression when compared with either treatment alone.	Caffeine	21-29	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	60-68
21967278-8	2012	Co-administration of caffeine with MDMA increased p-CREB, p-DARPP-32 and c-fos expression when compared with either treatment alone.	Caffeine	21-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
22345300-5	2012	Caffeine and Ang II increased the cell surface area of cardiomyocytes and the mRNA level of atrial natriuretic peptide, brain natriuretic peptide and beta-myosin heavy chain, but ionomycin did not.	Caffeine	0-8	natriuretic peptide B	Rattus norvegicus	120-145
21950736-0	2012	Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.	Caffeine	75-83	adenosine A2a receptor	Homo sapiens	17-24
22345300-5	2012	Caffeine and Ang II increased the cell surface area of cardiomyocytes and the mRNA level of atrial natriuretic peptide, brain natriuretic peptide and beta-myosin heavy chain, but ionomycin did not.	Caffeine	0-8	myosin heavy chain 7	Rattus norvegicus	150-173
22345300-6	2012	Moreover, sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) activity and the amplitudes of the twitch [Ca(2+)](i) transients were reduced in the caffeine-treated group and Ang II-treated group.	Caffeine	142-150	angiotensinogen	Rattus norvegicus	169-175
22385180-1	2012	CYP2E1, as a member of the cytochrome P450s (CYPs) super-family, is in charge of six percent drug metabolism involving a diversity of drugs distinct in structures and chemical properties, such as alcohols, monocyclic compounds (e.g., acetaminophen, benzene, p-nitrophenol), bicyclic heterocycles (e.g., coumarin, caffeine) and even fatty acids.	Caffeine	313-321	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
21480221-3	2012	Both CYP1A2 and N-acetyltransferase 2 (NAT2) phenotypic status were determined by a caffeine-based urinary assay.	Caffeine	84-92	N-acetyltransferase 2	Homo sapiens	39-43
22301547-8	2012	Treatment with the HER3-specific ligand neuregulin 1beta promoted the expression in a process that was antagonized by pharmacological and genetic interference with HER3 but not by the ataxia-telangiectasia-mutated (ATM) and ATM and Rad3-related protein kinases inhibitor caffeine.	Caffeine	271-279	erb-b2 receptor tyrosine kinase 3	Homo sapiens	19-23
22382681-5	2012	Doxorubicin-induced TG2 activity was suppressed by treatment with caffeine at the early phase, N-acetylcysteine at the mid-phase, and EGTA at the late phase.	Caffeine	66-74	transglutaminase 2	Homo sapiens	20-23
22113078-3	2012	In this study, we found that a group of xanthines including caffeine, theophylline, and dyphylline can dramatically decrease ABCG2 protein in cells that have either moderate (BeWo, a placental choriocarcinoma cell line) or high (MCF-7/MX100, a breast cancer drug-resistant cell subline) levels of ABCG2 expression.	Caffeine	60-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	125-130
21856371-0	2012	Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation.	Caffeine	0-8	caspase 3	Homo sapiens	91-100
22113078-3	2012	In this study, we found that a group of xanthines including caffeine, theophylline, and dyphylline can dramatically decrease ABCG2 protein in cells that have either moderate (BeWo, a placental choriocarcinoma cell line) or high (MCF-7/MX100, a breast cancer drug-resistant cell subline) levels of ABCG2 expression.	Caffeine	60-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	297-302
22113078-6	2012	As a consequence, caffeine treatment significantly increased the retention of an established ABCG2 substrate in MCF-7/MX100 cells but not in parental MCF-7 cells and sensitized the MDR cells to the chemotherapeutic agent mitoxantrone (MX); combination treatment with MX and caffeine decreased the IC(50) of MX ~10-fold and induced a greater degree of apoptotic cell death than MX treatment alone.	Caffeine	18-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	93-98
22113078-6	2012	As a consequence, caffeine treatment significantly increased the retention of an established ABCG2 substrate in MCF-7/MX100 cells but not in parental MCF-7 cells and sensitized the MDR cells to the chemotherapeutic agent mitoxantrone (MX); combination treatment with MX and caffeine decreased the IC(50) of MX ~10-fold and induced a greater degree of apoptotic cell death than MX treatment alone.	Caffeine	274-282	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	93-98
22223353-8	2012	The VF-related alterations in myocyte Ca(2+) cycling were mimicked by the RyR2 agonist, caffeine.	Caffeine	88-96	ryanodine receptor 2	Canis lupus familiaris	74-78
21796703-5	2012	Then the CYP 1A2 activity was expressed by using the caffeine metabolic ratio (CMR).	Caffeine	53-61	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	9-16
22154495-1	2012	Proton localized NMR spectroscopy (MRS) has been applied to study the diffusion of three small molecules, caffeine, theophylline and caprolactam, in chitosan gels with different concentration of water.	Caffeine	106-114	MROS	Homo sapiens	35-38
22298600-9	2012	Daytime DBP (77.0 vs 72.0 mm Hg, p = 0.04) also was significantly higher with the energy drink versus caffeine supplementation.	Caffeine	102-110	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11
22149008-6	2012	Reduction of the anti-inflammatory IL-1ra and IL-10 production was observed using higher caffeine concentrations only.	Caffeine	89-97	interleukin 1 receptor antagonist	Homo sapiens	35-41
22149008-6	2012	Reduction of the anti-inflammatory IL-1ra and IL-10 production was observed using higher caffeine concentrations only.	Caffeine	89-97	interleukin 10	Homo sapiens	46-51
22140065-7	2012	Depletion of Hsp25 transcripts by siRNA increased caffeine-mediated signaling, including ERK activation, and decreased the Ca2+ transient peak and expression of calsequestrin 2 in HL-1 cardiomyocytes.	Caffeine	50-58	heat shock protein family B (small) member 1	Homo sapiens	13-18
21612376-0	2012	Carbonic anhydrase I and II inhibition with natural products: caffeine and piperine.	Caffeine	62-70	carbonic anhydrase 1	Homo sapiens	0-27
21612376-2	2012	Caffeine and piperine were extracted and tested for inhibition of the human (h) cytosolic isoforms hCA I and II.	Caffeine	0-8	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	99-111
21612376-3	2012	The IC(50) values of caffeine against hCA I was of 55 mM, whereas that of piperine of 60 mM.	Caffeine	21-29	carbonic anhydrase 1	Homo sapiens	38-43
21612376-4	2012	The IC(50) values of caffeine and piperine against hCA II were of 2 mM.	Caffeine	21-29	carbonic anhydrase 2	Homo sapiens	51-57
21816445-12	2012	Exposure to caffeine or palmitate increased PDK4 mRNA in a cultured skeletal muscle system.	Caffeine	12-20	pyruvate dehydrogenase kinase 4	Homo sapiens	44-48
21984412-6	2012	This hyperphosphorylation can be partially prevented by inhibiting ATM activity with caffeine.	Caffeine	85-93	ATM serine/threonine kinase	Homo sapiens	67-70
22140065-6	2012	Furthermore, we found that Hsp25, one of the differentially expressed proteins, is modified by caffeine treatment.	Caffeine	95-103	heat shock protein family B (small) member 1	Homo sapiens	27-32
22214848-7	2012	Staining for c-fos demonstrated that administration of alcohol or caffeine induced neuronal activity in the basal ganglia in these mice.	Caffeine	66-74	FBJ osteosarcoma oncogene	Mus musculus	13-18
22140065-8	2012	These results suggest that proteins having various functions are involved in the regulation of Ca2+ homeostasis, and that Hsp25 plays an important role in regulating cardiac function during caffeine response.	Caffeine	190-198	heat shock protein family B (small) member 1	Homo sapiens	122-127
22169772-2	2012	In this work, the antinociceptive and toxic effects of two new coordination complexes: Cu2(fen)4(caf)2 [fen: fenoprofenate anion; caf: caffeine] and Cu2(fen)4(dmf)2 [dmf: N-N"-dimethylformamide] were evaluated in mice.	Caffeine	135-143	immunoglobulin kappa variable 1-35	Mus musculus	87-102
22169772-9	2012	These impaired parameters in mice exposed to Cu2(fen)4(caf)2 can be attributable to the presence of caffeine as stimulating agent.	Caffeine	100-108	immunoglobulin kappa variable 1-35	Mus musculus	45-60
22155266-0	2012	Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons.	Caffeine	8-16	carbonic anhydrase 1	Rattus norvegicus	182-185
22085758-11	2012	Caffeine reversal of acetaminophen results from actions in the spinal cord, as intrathecal DPCPX 10 nmol inhibited antinociception by systemic acetaminophen; this was also observed in +/+ but not in -/- adenosine A(1) receptor mice.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	203-226
22246422-4	2012	METHODS: CYP1A2 activity was determined by the paraxanthine/caffeine ratio in 184 smokers and in 113 of these smokers who were abstinent during a 4-week period.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15
22100783-0	2012	Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells.	Caffeine	35-43	steroidogenic acute regulatory protein	Homo sapiens	47-85
22100783-5	2012	This study was designed to investigate the direct effects and inheritable epigenetic mechanisms of caffeine on cortisol production and StAR expression in human adrenocortical cells.	Caffeine	99-107	steroidogenic acute regulatory protein	Homo sapiens	135-139
22100783-8	2012	In both acutely and chronically caffeine-treated cell groups, mRNA and protein expressions of StAR were stimulated in a dose-dependent manner.	Caffeine	32-40	steroidogenic acute regulatory protein	Homo sapiens	94-98
22100783-12	2012	The results showed that the StAR expression at post-caffeine passage 10 still increased, as compared with that in the control.	Caffeine	52-60	steroidogenic acute regulatory protein	Homo sapiens	28-32
22100783-13	2012	The caffeine-induced demethylation at nt -682 in StAR promoter underwent a similar time course as StAR expression does.	Caffeine	4-12	steroidogenic acute regulatory protein	Homo sapiens	49-53
22100783-13	2012	The caffeine-induced demethylation at nt -682 in StAR promoter underwent a similar time course as StAR expression does.	Caffeine	4-12	steroidogenic acute regulatory protein	Homo sapiens	98-102
23096362-4	2012	The checkpoint ATM/ATR kinases are involved in DSB repair, since the recorded frequency of CAs increased when both kinases were caffeine-abrogated.	Caffeine	128-136	ATM serine/threonine kinase	Homo sapiens	15-18
23096362-4	2012	The checkpoint ATM/ATR kinases are involved in DSB repair, since the recorded frequency of CAs increased when both kinases were caffeine-abrogated.	Caffeine	128-136	ATR serine/threonine kinase	Homo sapiens	19-22
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	ATM serine/threonine kinase	Homo sapiens	73-76
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	ATR serine/threonine kinase	Homo sapiens	122-125
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	tumor protein p53	Homo sapiens	171-174
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	175-178
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	179-183
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	forkhead box F1	Homo sapiens	198-203
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	forkhead box F1	Homo sapiens	246-251
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	ATM serine/threonine kinase	Homo sapiens	275-278
21964066-6	2012	The pharmacologic inhibitor (caffeine) of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR) protein kinases abolished activation of the p53-p21(WAF1) pathway upon FOXF1 knockdown, suggesting that suppression of FOXF1 function triggered the ATM/ATR-mediated DNA damage response.	Caffeine	29-37	ATR serine/threonine kinase	Homo sapiens	279-282
22613970-5	2012	We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) beta-cells compared to controls.	Caffeine	83-91	annexin A7	Mus musculus	154-158
22055309-3	2012	At higher initial concentrations (10 muM) the indirect photolysis of caffeine occurs predominantly through reaction with the hydroxyl radical (OHi) generated by irradiated fulvic acids.	Caffeine	69-77	latexin	Homo sapiens	37-40
22075053-4	2012	An arbitrary threshold of 400 ng caffeine L(-1) allows us to identify samples with an elevated fecal contamination, as defined by more than 200 colony-forming units per 100 mL (cfu 100 mL(-1)) of fecal coliforms.	Caffeine	33-41	L1 cell adhesion molecule	Mus musculus	42-47
22055309-6	2012	At lower initial concentrations (0.1 muM) caffeine photolysis reactions proceed even more quickly in fulvic acid solutions and are influenced by both short- and long-lived reactive species.	Caffeine	42-50	latexin	Homo sapiens	37-40
22075053-4	2012	An arbitrary threshold of 400 ng caffeine L(-1) allows us to identify samples with an elevated fecal contamination, as defined by more than 200 colony-forming units per 100 mL (cfu 100 mL(-1)) of fecal coliforms.	Caffeine	33-41	L1 cell adhesion molecule	Mus musculus	185-191
21842269-14	2012	Expression levels of NTPDase 1 and 5 decreased in hippocampi of caffeine-treated rats.	Caffeine	64-72	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	21-36
22504320-8	2012	In conclusion, our results demonstrated the upregulation of LRP1 and P-gp at the BBB by rifampicin and caffeine enhanced brain Abeta clearance, and this effect could explain, at least in part, the protective effect of rifampicin and caffeine against AD.	Caffeine	103-111	low density lipoprotein receptor-related protein 1	Mus musculus	60-64
22504320-8	2012	In conclusion, our results demonstrated the upregulation of LRP1 and P-gp at the BBB by rifampicin and caffeine enhanced brain Abeta clearance, and this effect could explain, at least in part, the protective effect of rifampicin and caffeine against AD.	Caffeine	103-111	phosphoglycolate phosphatase	Mus musculus	69-73
22504320-8	2012	In conclusion, our results demonstrated the upregulation of LRP1 and P-gp at the BBB by rifampicin and caffeine enhanced brain Abeta clearance, and this effect could explain, at least in part, the protective effect of rifampicin and caffeine against AD.	Caffeine	233-241	low density lipoprotein receptor-related protein 1	Mus musculus	60-64
22504320-8	2012	In conclusion, our results demonstrated the upregulation of LRP1 and P-gp at the BBB by rifampicin and caffeine enhanced brain Abeta clearance, and this effect could explain, at least in part, the protective effect of rifampicin and caffeine against AD.	Caffeine	233-241	phosphoglycolate phosphatase	Mus musculus	69-73
23118658-0	2012	Relationship of caffeine dosing with serum alkaline phosphatase levels in extremely low-birth-weight infants.	Caffeine	16-24	alkaline phosphatase, placental	Homo sapiens	43-63
23118658-1	2012	OBJECTIVE: To determine whether patients receiving higher doses of caffeine have increased alkaline phosphatase (ALP) levels, as a biomarker for osteopenia.	Caffeine	67-75	alkaline phosphatase, placental	Homo sapiens	91-111
23118658-1	2012	OBJECTIVE: To determine whether patients receiving higher doses of caffeine have increased alkaline phosphatase (ALP) levels, as a biomarker for osteopenia.	Caffeine	67-75	alkaline phosphatase, placental	Homo sapiens	113-116
22673010-0	2012	Changes in CYP1A2 activity in humans after 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) administration using caffeine as a probe drug.	Caffeine	114-122	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	11-17
22673010-3	2012	After assessing the inhibition and recovery of CYP2D6 in a previous study, the aim of this work was to study in humans the activity of CYP1A2 in vivo after CYP2D6 had been inhibited by MDMA, using caffeine as a probe drug.	Caffeine	197-205	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-141
22504320-3	2012	In this study, we have hypothesized that enhanced amyloid-beta (Abeta) clearance from the brain across the blood-brain barrier (BBB) of wild-type mice treated with rifampicin or caffeine is caused by both drugs potential to upregulate low-density lipoprotein receptor related protein-1 (LRP1) and/or P-glycoprotein (P-gp) at the BBB.	Caffeine	178-186	low density lipoprotein receptor-related protein 1	Mus musculus	235-285
22504320-3	2012	In this study, we have hypothesized that enhanced amyloid-beta (Abeta) clearance from the brain across the blood-brain barrier (BBB) of wild-type mice treated with rifampicin or caffeine is caused by both drugs potential to upregulate low-density lipoprotein receptor related protein-1 (LRP1) and/or P-glycoprotein (P-gp) at the BBB.	Caffeine	178-186	low density lipoprotein receptor-related protein 1	Mus musculus	287-291
22504320-3	2012	In this study, we have hypothesized that enhanced amyloid-beta (Abeta) clearance from the brain across the blood-brain barrier (BBB) of wild-type mice treated with rifampicin or caffeine is caused by both drugs potential to upregulate low-density lipoprotein receptor related protein-1 (LRP1) and/or P-glycoprotein (P-gp) at the BBB.	Caffeine	178-186	phosphoglycolate phosphatase	Mus musculus	300-314
22504320-3	2012	In this study, we have hypothesized that enhanced amyloid-beta (Abeta) clearance from the brain across the blood-brain barrier (BBB) of wild-type mice treated with rifampicin or caffeine is caused by both drugs potential to upregulate low-density lipoprotein receptor related protein-1 (LRP1) and/or P-glycoprotein (P-gp) at the BBB.	Caffeine	178-186	phosphoglycolate phosphatase	Mus musculus	316-320
22504320-4	2012	Expression studies of LRP1 and P-gp in brain endothelial cells and isolated mice brain microvessels following treatment with rifampicin or caffeine demonstrated both drugs as P-gp inducers, and only rifampicin as an LRP1 inducer.	Caffeine	139-147	low density lipoprotein receptor-related protein 1	Mus musculus	22-26
22504320-4	2012	Expression studies of LRP1 and P-gp in brain endothelial cells and isolated mice brain microvessels following treatment with rifampicin or caffeine demonstrated both drugs as P-gp inducers, and only rifampicin as an LRP1 inducer.	Caffeine	139-147	phosphoglycolate phosphatase	Mus musculus	31-35
22900152-3	2012	Hepatic fatty acid synthase (FAS) activity in the catechins + caffeine group was significantly lower, and the activities of acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase-II (CPT-II) were significantly higher, compared to the control group.	Caffeine	62-70	fatty acid synthase	Mus musculus	8-27
22900152-3	2012	Hepatic fatty acid synthase (FAS) activity in the catechins + caffeine group was significantly lower, and the activities of acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase-II (CPT-II) were significantly higher, compared to the control group.	Caffeine	62-70	fatty acid synthase	Mus musculus	29-32
22900152-5	2012	FAS mRNA expression levels in the catechins + caffeine group were significantly lower than in the control group.	Caffeine	46-54	fatty acid synthase	Mus musculus	0-3
22686318-4	2012	Further, in a pilot study, 28 colorectal cancer patients were NAT2 phenotyped by the caffeine test.	Caffeine	85-93	N-acetyltransferase 2	Homo sapiens	62-66
22343183-7	2012	The IP(3)R antagonists caffeine (10 microM), heparin and intracellular 2-APB prevented inhibition to a lesser extent.	Caffeine	23-31	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	4-10
22343183-8	2012	The ryanodine receptor (RyR) antagonists ryanodine and dantrolene prevented inhibition, and the RyR agonist caffeine (30 mM) mimicked the effects of KP-10 on Ca(2+) currents.	Caffeine	108-116	ryanodine receptor 1, skeletal muscle	Mus musculus	96-99
23061906-4	2012	The ratios of the percent mitotic cells/caspase-3 positive cells in tumors from the caffeine-treated, RW-treated, or combination-treated mice were decreased by 34%, 38%, and 52%, respectively.	Caffeine	84-92	caspase 3	Mus musculus	40-49
23272120-0	2012	Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.	Caffeine	22-30	surfactant protein B	Homo sapiens	68-88
23272120-4	2012	Administration of dexamethasone (1 microM) or caffeine (5 mM) stimulated SP-B mRNA expression with a maximal of 38.8+-11.1-fold and 5.2+-1.4-fold increase, respectively.	Caffeine	46-54	surfactant protein B	Homo sapiens	73-77
23272120-6	2012	SP-B mRNA was synergistically induced also by administration of caffeine with hydrocortisone (87.9+-39.0), prednisolone (154+-66.8), and betamethasone (123+-6.4).	Caffeine	64-72	surfactant protein B	Homo sapiens	0-4
23272120-9	2012	In accordance with mRNA data, mature SP-B was induced significantly by dexamethasone with caffeine (13.8+-9.0-fold increase, p = 0.0134).	Caffeine	90-98	surfactant protein B	Homo sapiens	37-41
23272120-0	2012	Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.	Caffeine	22-30	surfactant protein B	Homo sapiens	90-94
23272120-10	2012	We found a synergistic upregulation of SP-B mRNA expression induced by co-administration of various glucocorticoids and caffeine, achieved by accumulation of intracellular cAMP.	Caffeine	120-128	surfactant protein B	Homo sapiens	39-43
23272120-2	2012	The present study investigated the effect of caffeine and different glucocorticoids on expression of surfactant protein (SP)-B, crucial for the physiological function of pulmonary surfactant.	Caffeine	45-53	surfactant protein B	Homo sapiens	101-126
22970234-7	2012	Moreover, caffeine ingestion significantly increased the levels of maternal and fetal blood CORT and decreased the expression of placental 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD-2).	Caffeine	10-18	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	139-176
23029527-5	2012	We found that Cdt1 degradation was attenuated in the presence of caffeine.	Caffeine	65-73	chromatin licensing and DNA replication factor 1	Homo sapiens	14-18
23029527-9	2012	Cdt1 degradation was also induced by DNA damaging chemicals such as methyl methanesulfonate (MMS) or zeocin, depending on PCNA and CRL4-Cdt2, though it was less caffeine-sensitive.	Caffeine	161-169	chromatin licensing and DNA replication factor 1	Homo sapiens	0-4
22970234-7	2012	Moreover, caffeine ingestion significantly increased the levels of maternal and fetal blood CORT and decreased the expression of placental 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD-2).	Caffeine	10-18	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	178-190
22970234-8	2012	Additionally, both in vivo and in vitro studies show that caffeine can downregulate the expression of fetal hippocampal 11beta-HSD-2, promote the expression of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor (GR), and enhance DNA methylation within the hippocampal 11beta-HSD-2 promoter.	Caffeine	58-66	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	120-132
22970234-8	2012	Additionally, both in vivo and in vitro studies show that caffeine can downregulate the expression of fetal hippocampal 11beta-HSD-2, promote the expression of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor (GR), and enhance DNA methylation within the hippocampal 11beta-HSD-2 promoter.	Caffeine	58-66	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	160-197
22970234-8	2012	Additionally, both in vivo and in vitro studies show that caffeine can downregulate the expression of fetal hippocampal 11beta-HSD-2, promote the expression of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor (GR), and enhance DNA methylation within the hippocampal 11beta-HSD-2 promoter.	Caffeine	58-66	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	202-225
22970234-8	2012	Additionally, both in vivo and in vitro studies show that caffeine can downregulate the expression of fetal hippocampal 11beta-HSD-2, promote the expression of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor (GR), and enhance DNA methylation within the hippocampal 11beta-HSD-2 promoter.	Caffeine	58-66	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	227-229
22970234-8	2012	Additionally, both in vivo and in vitro studies show that caffeine can downregulate the expression of fetal hippocampal 11beta-HSD-2, promote the expression of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor (GR), and enhance DNA methylation within the hippocampal 11beta-HSD-2 promoter.	Caffeine	58-66	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	283-295
22470550-6	2012	Immunocytochemistry of caffeine-treated embryos using neural crest cell markers also demonstrated uncharacteristic features; HNK1 labeled migratory crest cells exhibited an incontinuous dorsal-ventral migration trajectory, though Pax7 positive cells of the caffeine-treated groups were comparatively similar to the control.	Caffeine	23-31	paired box 7	Gallus gallus	230-234
22701600-0	2012	Caffeine reduces 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.	Caffeine	0-8	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	17-59
22701600-2	2012	Since there is evidence that decreased placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is linked to fetal growth restriction, we hypothesized that caffeine may inhibit fetal growth partly through down regulating placental 11beta-HSD2.	Caffeine	166-174	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	49-104
22701600-2	2012	Since there is evidence that decreased placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is linked to fetal growth restriction, we hypothesized that caffeine may inhibit fetal growth partly through down regulating placental 11beta-HSD2.	Caffeine	166-174	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	93-104
22701600-3	2012	As a first step in examining this hypothesis, we studied the effects of caffeine on placental 11beta-HSD2 activity and expression using our established primary human trophoblast cells as an in vitro model system.	Caffeine	72-80	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	94-105
22701600-6	2012	Taken together, these findings reveal that placental 11beta-HSD2 is a novel molecular target through which caffeine may adversely affect fetal growth.	Caffeine	107-115	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	53-64
22896810-4	2012	Here, we observed that ablation of D. discoideumplaA, which encodes a phospholipase A2 (PLA2) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid.	Caffeine	154-162	phospholipase A2 group IB	Homo sapiens	70-86
22896810-4	2012	Here, we observed that ablation of D. discoideumplaA, which encodes a phospholipase A2 (PLA2) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid.	Caffeine	154-162	phospholipase A2 group IB	Homo sapiens	88-92
22896810-5	2012	Moreover, the inhibition of PLA2 activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA2-dependent signalling.	Caffeine	144-152	phospholipase A2 group IB	Homo sapiens	28-32
22896810-5	2012	Moreover, the inhibition of PLA2 activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA2-dependent signalling.	Caffeine	185-193	phospholipase A2 group IB	Homo sapiens	28-32
22896810-5	2012	Moreover, the inhibition of PLA2 activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA2-dependent signalling.	Caffeine	185-193	phospholipase A2 group IB	Homo sapiens	229-233
22079292-9	2011	In addition, knockdown of Orai1 resulted in lower baseline Ca(2+) and an attenuated response to thapsigargin (TG) and caffeine, indicating that SOCE may play a role in Ca(2+) homeostasis during unstressed conditions in cardiomyocytes.	Caffeine	118-126	ORAI calcium release-activated calcium modulator 1	Homo sapiens	26-31
22055712-8	2011	The results of this study are discussed with reference to possible binding orientations of selected caffeine analogues within the active site cavities of MAO-A and -B.	Caffeine	100-108	monoamine oxidase A	Homo sapiens	154-166
21998325-9	2011	Compartmentalized activation extends to functional differences in target phosphorylation at CaMKII sites: phenylephrine increases histone deacetylase 5 phosphorylation (Ser498) but not phospholamban (Thr17), whereas the converse holds for caffeine.	Caffeine	239-247	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	92-98
22059381-5	2011	The results suggest that all components show varied inhibitory effects on the formation of toxic hIAPP amyloids, in which CA shows the highest potency in delaying the conformational transition of the hIAPP molecule with the most prolonged lag time, whereas caffeine shows the lowest potency.	Caffeine	257-265	islet amyloid polypeptide	Homo sapiens	97-102
21940847-9	2011	In addition, caffeine suppressed the phosphorylation of insulin-stimulated IRS-1 Ser(636/639) and upstream kinases, including the mammalian target of rapamycin and p70S6 kinase.	Caffeine	13-21	insulin receptor substrate 1	Rattus norvegicus	75-80
21940847-0	2011	Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle.	Caffeine	0-8	insulin receptor substrate 1	Rattus norvegicus	38-66
21940847-9	2011	In addition, caffeine suppressed the phosphorylation of insulin-stimulated IRS-1 Ser(636/639) and upstream kinases, including the mammalian target of rapamycin and p70S6 kinase.	Caffeine	13-21	mechanistic target of rapamycin kinase	Homo sapiens	130-159
21940847-5	2011	Furthermore, caffeine enhanced phosphorylation of IRS-1 Ser(307) and an IRS-1 Ser(307) kinase, inhibitor-kappaB kinase (IKK)-alpha/beta Ser(176/180).	Caffeine	13-21	insulin receptor substrate 1	Rattus norvegicus	50-55
21940847-5	2011	Furthermore, caffeine enhanced phosphorylation of IRS-1 Ser(307) and an IRS-1 Ser(307) kinase, inhibitor-kappaB kinase (IKK)-alpha/beta Ser(176/180).	Caffeine	13-21	insulin receptor substrate 1	Rattus norvegicus	72-77
21940847-10	2011	Intravenous injection of caffeine at a physiological dose (5 mg/kg) in rats inhibited the phosphorylation of insulin-stimulated IRS-1 Tyr(612) and Akt Ser(473) in epitrochlearis muscle.	Caffeine	25-33	insulin receptor substrate 1	Rattus norvegicus	128-133
21940847-6	2011	Blockade of IKK/IRS-1 Ser(307) by caffeic acid ameliorated the caffeine-induced downregulation of IRS-1 Tyr(612) phosphorylation and 3MG transport.	Caffeine	63-71	insulin receptor substrate 1	Rattus norvegicus	16-21
21940847-6	2011	Blockade of IKK/IRS-1 Ser(307) by caffeic acid ameliorated the caffeine-induced downregulation of IRS-1 Tyr(612) phosphorylation and 3MG transport.	Caffeine	63-71	insulin receptor substrate 1	Rattus norvegicus	98-103
21940847-10	2011	Intravenous injection of caffeine at a physiological dose (5 mg/kg) in rats inhibited the phosphorylation of insulin-stimulated IRS-1 Tyr(612) and Akt Ser(473) in epitrochlearis muscle.	Caffeine	25-33	AKT serine/threonine kinase 1	Rattus norvegicus	147-150
21940847-7	2011	Caffeine also increased the phosphorylation of IRS-1 Ser(789) and an IRS-1 Ser(789) kinase, 5"-AMP-activated protein kinase (AMPK).	Caffeine	0-8	insulin receptor substrate 1	Rattus norvegicus	47-52
21940847-7	2011	Caffeine also increased the phosphorylation of IRS-1 Ser(789) and an IRS-1 Ser(789) kinase, 5"-AMP-activated protein kinase (AMPK).	Caffeine	0-8	insulin receptor substrate 1	Rattus norvegicus	69-74
21940847-11	2011	Our results indicate that caffeine inhibits insulin signaling partly through the IKK/IRS-1 Ser(307) pathway, via a Ca(2+)- and AMPK-independent mechanism in skeletal muscle.	Caffeine	26-34	insulin receptor substrate 1	Rattus norvegicus	85-90
22101644-0	2011	Caffeine-induced synaptic potentiation in hippocampal CA2 neurons.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	54-57
21970461-0	2011	Computational study of the binding modes of caffeine to the adenosine A2A receptor.	Caffeine	44-52	adenosine A2a receptor	Homo sapiens	60-82
21970461-1	2011	Using the recently solved crystal structure of the human adenosine A(2A) receptor, we applied MM/PBSA to compare the binding modes of caffeine with those of the high-affinity selective antagonist ZM241385.	Caffeine	134-142	adenosine A2a receptor	Homo sapiens	57-81
22024172-6	2011	The administration of a lipocalin-type PGD synthase inhibitor (SeCl4), DP1 antagonist (ONO-4127Na) or adenosine A2A receptor antagonist (caffeine) suppresses both NREM and rapid eye movement (REM) sleep, indicating that the PGD2-adenosine system is crucial for the maintenance of physiological sleep.	Caffeine	137-145	adenosine A2a receptor	Homo sapiens	102-124
22024172-6	2011	The administration of a lipocalin-type PGD synthase inhibitor (SeCl4), DP1 antagonist (ONO-4127Na) or adenosine A2A receptor antagonist (caffeine) suppresses both NREM and rapid eye movement (REM) sleep, indicating that the PGD2-adenosine system is crucial for the maintenance of physiological sleep.	Caffeine	137-145	prostaglandin D2 synthase	Homo sapiens	224-228
22101644-3	2011	We found that physiological doses of caffeine in vivo or A(1)R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.	Caffeine	37-45	carbonic anhydrase 2	Rattus norvegicus	158-161
21918424-6	2011	Effects of all possible heterotypic expression conditions on RYR1 sensitivity to caffeine-induced Ca release were determined in expressing RYR1-null myotubes.	Caffeine	81-89	ryanodine receptor 1	Homo sapiens	61-65
21918424-7	2011	RESULTS: Compared with wild-type RYR1 alone (EC50 = 2.85 +- 0.49 mM), average (+- SEM) caffeine sensitivity of Ca release was modestly increased after coexpression with either R3983C (EC50 = 2.00 +- 0.39 mM) or D4505H (EC50 = 1.64 +- 0.24 mM).	Caffeine	87-95	ryanodine receptor 1	Homo sapiens	33-37
21684175-0	2011	alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2.	Caffeine	22-30	N-acetyltransferase 2	Homo sapiens	89-93
21918424-8	2011	Remarkably, coexpression of wild-type RYR1 with the double mutant in cis (R3983C-D4505H) produced a significantly stronger sensitization of caffeine-induced Ca release (EC50 = 0.64 +- 0.17 mM) compared with that observed after coexpression of the two variants on separate subunits (EC50 = 1.53 +- 0.18 mM).	Caffeine	140-148	ryanodine receptor 1	Homo sapiens	38-42
21918424-9	2011	CONCLUSIONS: The R3983C mutation potentiates D4505H-mediated sensitization of caffeine-induced RYR1 Ca release when the mutations are in cis (on the same subunit) but not when present on separate subunits.	Caffeine	78-86	ryanodine receptor 1	Homo sapiens	95-99
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	Caffeine	19-27	DNA damage inducible transcript 3	Gallus gallus	122-128
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	Caffeine	19-27	growth arrest and DNA damage inducible alpha	Gallus gallus	133-144
21945951-6	2011	This activation was strongly attenuated by two inhibitors of the ATM kinase (caffeine and Ku-55933), which is dysfunctional in ataxia-telanagiectasia patients.	Caffeine	77-85	ATM serine/threonine kinase	Homo sapiens	65-68
21745187-0	2011	Adaphostin promotes caffeine-evoked autocrine Fas-mediated death pathway activation in Bcr/Abl-positive leukaemia cells.	Caffeine	20-28	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-94
21745187-2	2011	Co-treatment with adaphostin (a Bcr/Abl inhibitor) was found to potentiate caffeine-induced Fas/FasL up-regulation.	Caffeine	75-83	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	32-39
21745187-2	2011	Co-treatment with adaphostin (a Bcr/Abl inhibitor) was found to potentiate caffeine-induced Fas/FasL up-regulation.	Caffeine	75-83	Fas ligand	Homo sapiens	96-100
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	68-76	mitogen-activated protein kinase 14	Homo sapiens	15-18
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	68-76	mitogen-activated protein kinase 8	Homo sapiens	28-31
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	68-76	Fas ligand	Homo sapiens	46-50
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	82-90	mitogen-activated protein kinase 14	Homo sapiens	15-18
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	82-90	mitogen-activated protein kinase 8	Homo sapiens	28-31
21745187-4	2011	Suppression of p38 MAPK and JNK abrogated Fas/FasL up-regulation in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	82-90	Fas ligand	Homo sapiens	46-50
21745187-6	2011	MKP-1 down-regulation eventually elucidated the enhanced effect of adaphostin on p38 MAPK/JNK activation and subsequent Fas/FasL up-regulation in caffeine-treated cells.	Caffeine	146-154	dual specificity phosphatase 1	Homo sapiens	0-5
21745187-6	2011	MKP-1 down-regulation eventually elucidated the enhanced effect of adaphostin on p38 MAPK/JNK activation and subsequent Fas/FasL up-regulation in caffeine-treated cells.	Caffeine	146-154	mitogen-activated protein kinase 14	Homo sapiens	81-84
21745187-6	2011	MKP-1 down-regulation eventually elucidated the enhanced effect of adaphostin on p38 MAPK/JNK activation and subsequent Fas/FasL up-regulation in caffeine-treated cells.	Caffeine	146-154	mitogen-activated protein kinase 8	Homo sapiens	90-93
21745187-6	2011	MKP-1 down-regulation eventually elucidated the enhanced effect of adaphostin on p38 MAPK/JNK activation and subsequent Fas/FasL up-regulation in caffeine-treated cells.	Caffeine	146-154	Fas ligand	Homo sapiens	124-128
21745187-7	2011	Knockdown of p38alpha MAPK and JNK1, ATF-2 (activating transcription factor 2) and c-Jun by siRNA (small interfering RNA) proved that p38alpha MAPK/ATF-2 and JNK1/c-Jun pathways were responsible for caffeine-evoked Fas/FasL up-regulation.	Caffeine	199-207	mitogen-activated protein kinase 14	Homo sapiens	13-21
21745187-7	2011	Knockdown of p38alpha MAPK and JNK1, ATF-2 (activating transcription factor 2) and c-Jun by siRNA (small interfering RNA) proved that p38alpha MAPK/ATF-2 and JNK1/c-Jun pathways were responsible for caffeine-evoked Fas/FasL up-regulation.	Caffeine	199-207	mitogen-activated protein kinase 14	Homo sapiens	134-142
21745187-7	2011	Knockdown of p38alpha MAPK and JNK1, ATF-2 (activating transcription factor 2) and c-Jun by siRNA (small interfering RNA) proved that p38alpha MAPK/ATF-2 and JNK1/c-Jun pathways were responsible for caffeine-evoked Fas/FasL up-regulation.	Caffeine	199-207	activating transcription factor 2	Homo sapiens	148-153
21745187-7	2011	Knockdown of p38alpha MAPK and JNK1, ATF-2 (activating transcription factor 2) and c-Jun by siRNA (small interfering RNA) proved that p38alpha MAPK/ATF-2 and JNK1/c-Jun pathways were responsible for caffeine-evoked Fas/FasL up-regulation.	Caffeine	199-207	mitogen-activated protein kinase 8	Homo sapiens	158-162
21745187-7	2011	Knockdown of p38alpha MAPK and JNK1, ATF-2 (activating transcription factor 2) and c-Jun by siRNA (small interfering RNA) proved that p38alpha MAPK/ATF-2 and JNK1/c-Jun pathways were responsible for caffeine-evoked Fas/FasL up-regulation.	Caffeine	199-207	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-168
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	146-154	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	89-93
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	146-154	AKT serine/threonine kinase 1	Homo sapiens	109-112
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	146-154	mitogen-activated protein kinase 1	Homo sapiens	113-116
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	160-168	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	89-93
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	160-168	AKT serine/threonine kinase 1	Homo sapiens	109-112
21745187-8	2011	Moreover, Ca2+ and ROS (reactive oxygen species) were demonstrated to be responsible for ASK1 activation and Akt/ERK inactivation respectively in caffeine- and caffeine/adaphostin-treated cells.	Caffeine	160-168	mitogen-activated protein kinase 1	Homo sapiens	113-116
21745187-9	2011	Likewise, adaphostin functionally enhanced caffeine-induced Fas/FasL up-regulation in leukaemia cells that expressed Bcr/Abl.	Caffeine	43-51	Fas ligand	Homo sapiens	64-68
21745187-9	2011	Likewise, adaphostin functionally enhanced caffeine-induced Fas/FasL up-regulation in leukaemia cells that expressed Bcr/Abl.	Caffeine	43-51	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	117-124
21914471-0	2011	Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio).	Caffeine	18-26	brain-derived neurotrophic factor	Danio rerio	88-92
21825094-5	2011	This finding may be of pharmacological relevance, because hCNT1 is known to interact with anticancer nucleoside-derived drugs and other molecules, such as nicotine and caffeine, for which a great variety of harmful effects on placental and fetal development, including intrauterine growth retardation, have been reported.	Caffeine	168-176	solute carrier family 28 member 1	Homo sapiens	58-63
21914471-3	2011	In this study, we aimed to evaluate if caffeine gave to zebrafish in the very first steps of development is able to affect its direct targets, through the adenosine receptors mRNA expression evaluation, and latter indirect targets, through evaluation of the pattern of dopamine and cAMP-regulated phosphoprotein and brain-derived neurotrophic factor (BDNF) mRNA expression.	Caffeine	39-47	brain-derived neurotrophic factor	Danio rerio	316-349
21914471-3	2011	In this study, we aimed to evaluate if caffeine gave to zebrafish in the very first steps of development is able to affect its direct targets, through the adenosine receptors mRNA expression evaluation, and latter indirect targets, through evaluation of the pattern of dopamine and cAMP-regulated phosphoprotein and brain-derived neurotrophic factor (BDNF) mRNA expression.	Caffeine	39-47	brain-derived neurotrophic factor	Danio rerio	351-355
21914471-9	2011	BDNF was also expressed since 24 hpf and caffeine treatment increased its expression at 48 and 72 hpf.	Caffeine	41-49	brain-derived neurotrophic factor	Danio rerio	0-4
21907331-0	2011	Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer"s transgenic mice.	Caffeine	0-8	mitogen-activated protein kinase 8	Mus musculus	57-60
21862589-6	2011	The mutant RyR1 was expressed in HEK cells, and CICR activity was investigated by caffeine-induced Ca(2+) release, single-channel current recordings, and [(3)H]ryanodine binding.	Caffeine	82-90	ryanodine receptor 1	Homo sapiens	11-15
21907331-0	2011	Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer"s transgenic mice.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	65-68
21907331-6	2011	Caffeine treatment stimulated PKA activity, increased phospho-CREB levels, and decreased phospho-JNK and phospho-ERK expression in the striatum of APPswe mice, all of which are thought to be beneficial changes for brain function.	Caffeine	0-8	cAMP responsive element binding protein 1	Mus musculus	62-66
21907331-6	2011	Caffeine treatment stimulated PKA activity, increased phospho-CREB levels, and decreased phospho-JNK and phospho-ERK expression in the striatum of APPswe mice, all of which are thought to be beneficial changes for brain function.	Caffeine	0-8	mitogen-activated protein kinase 8	Mus musculus	97-100
21907331-6	2011	Caffeine treatment stimulated PKA activity, increased phospho-CREB levels, and decreased phospho-JNK and phospho-ERK expression in the striatum of APPswe mice, all of which are thought to be beneficial changes for brain function.	Caffeine	0-8	mitogen-activated protein kinase 1	Mus musculus	113-116
21907331-8	2011	In the frontal cortex, caffeine did not significantly increase phospho-CREB and PKA activity, but significantly reduced phospho-JNK and phospho-ERK expression in both APPswe and NT mice.	Caffeine	23-31	mitogen-activated protein kinase 8	Mus musculus	128-131
21846718-1	2011	Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens.	Caffeine	134-142	catechol-O-methyltransferase	Homo sapiens	0-28
21846718-1	2011	Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens.	Caffeine	134-142	catechol-O-methyltransferase	Homo sapiens	30-34
21949167-4	2011	Consumption of caffeine was measured from validated questionnaires completed from May 1, 1980, through April 1, 2004, and computed as cumulative mean consumption with a 2-year latency period applied.	Caffeine	15-23	protein kinase C delta	Homo sapiens	82-87
21191826-2	2011	High doses of caffeine induce neuronal activation with Ca2+ influx followed by expression of the immediate early gene c-fos.	Caffeine	14-22	carbonic anhydrase 2	Homo sapiens	55-58
21191826-2	2011	High doses of caffeine induce neuronal activation with Ca2+ influx followed by expression of the immediate early gene c-fos.	Caffeine	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
21191826-3	2011	In the present study, we investigated c-Fos protein expression in stress-responsive brain areas induced by caffeine, as well as the role of alpha2A receptor in the regulation of neuronal activation.	Caffeine	107-115	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
21191826-4	2011	Immunohistochemical analysis showed that an acute effect of caffeine induced c-Fos protein expression in the hippocampus, the bed nucleus of stria terminalis (BNST), the lateral septum, the basolateral and central amygdala, the paraventricular hypothalamic nucleus (PVN), the locus coeruleus, and the lateral parabrachial nucleus (LPBN).	Caffeine	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
21191826-5	2011	However, c-Fos expression was attenuated after repeated treatment of caffeine, spaced 24 h apart, compared to a single acute effect.	Caffeine	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-14
21191826-6	2011	Alpha2A receptor activation with the agonist guanfacine attenuated the acute effect of caffeine in terms of c-Fos expression in neurons in the CA1-CA3 areas of hippocampus, the locus coeruleus and the LPBN as compared with effect of caffeine alone, whereas the number of c-Fos expressing neurons increased in the lateral septum, the dorsal BNST, the central amygdala, and the PVN, areas that are densely innervated by noradrenergic neurons.	Caffeine	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
21191826-6	2011	Alpha2A receptor activation with the agonist guanfacine attenuated the acute effect of caffeine in terms of c-Fos expression in neurons in the CA1-CA3 areas of hippocampus, the locus coeruleus and the LPBN as compared with effect of caffeine alone, whereas the number of c-Fos expressing neurons increased in the lateral septum, the dorsal BNST, the central amygdala, and the PVN, areas that are densely innervated by noradrenergic neurons.	Caffeine	87-95	carbonic anhydrase 1	Homo sapiens	143-146
21191826-6	2011	Alpha2A receptor activation with the agonist guanfacine attenuated the acute effect of caffeine in terms of c-Fos expression in neurons in the CA1-CA3 areas of hippocampus, the locus coeruleus and the LPBN as compared with effect of caffeine alone, whereas the number of c-Fos expressing neurons increased in the lateral septum, the dorsal BNST, the central amygdala, and the PVN, areas that are densely innervated by noradrenergic neurons.	Caffeine	87-95	carbonic anhydrase 3	Homo sapiens	147-150
21191826-6	2011	Alpha2A receptor activation with the agonist guanfacine attenuated the acute effect of caffeine in terms of c-Fos expression in neurons in the CA1-CA3 areas of hippocampus, the locus coeruleus and the LPBN as compared with effect of caffeine alone, whereas the number of c-Fos expressing neurons increased in the lateral septum, the dorsal BNST, the central amygdala, and the PVN, areas that are densely innervated by noradrenergic neurons.	Caffeine	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	271-276
21191826-6	2011	Alpha2A receptor activation with the agonist guanfacine attenuated the acute effect of caffeine in terms of c-Fos expression in neurons in the CA1-CA3 areas of hippocampus, the locus coeruleus and the LPBN as compared with effect of caffeine alone, whereas the number of c-Fos expressing neurons increased in the lateral septum, the dorsal BNST, the central amygdala, and the PVN, areas that are densely innervated by noradrenergic neurons.	Caffeine	233-241	carbonic anhydrase 3	Homo sapiens	147-150
21742996-4	2011	The HRC(S96A) mutant exacerbated the inhibitory effects of HRC(WT) on the amplitude of Ca(2+) transients, prolongation of Ca(2+) decay time, and caffeine-induced sarcoplasmic reticulum Ca(2+) release.	Caffeine	145-153	histidine rich calcium binding protein	Homo sapiens	4-8
21742996-4	2011	The HRC(S96A) mutant exacerbated the inhibitory effects of HRC(WT) on the amplitude of Ca(2+) transients, prolongation of Ca(2+) decay time, and caffeine-induced sarcoplasmic reticulum Ca(2+) release.	Caffeine	145-153	histidine rich calcium binding protein	Homo sapiens	4-7
21593482-8	2011	Caffeine (inhibits both ATM and ATR), but not KU55933 (ATM-selective inhibitor), reversed the G(2)-M block induced by UV, inferring a primary role for ATR in sensing this form of DNA damage.	Caffeine	0-8	ataxia telangiectasia mutated	Mus musculus	24-27
21613275-5	2011	Sensitization and inhibition of RyR clusters shortened and lengthened, respectively, the median interval between consecutive Ca(2+) sparks (caffeine 239 ms; control 280 ms; tetracaine 453 ms).	Caffeine	140-148	ryanodine receptor 2	Rattus norvegicus	32-35
21896655-5	2011	A binding site for CncC and its heterodimer partner Maf (muscle aponeurosis fibromatosis) is sufficient and necessary for robust transcriptional responses to three xenobiotic compounds: phenobarbital (PB), chlorpromazine, and caffeine.	Caffeine	226-234	cap-n-collar	Drosophila melanogaster	19-23
21593482-8	2011	Caffeine (inhibits both ATM and ATR), but not KU55933 (ATM-selective inhibitor), reversed the G(2)-M block induced by UV, inferring a primary role for ATR in sensing this form of DNA damage.	Caffeine	0-8	ataxia telangiectasia and Rad3 related	Mus musculus	32-35
21593482-8	2011	Caffeine (inhibits both ATM and ATR), but not KU55933 (ATM-selective inhibitor), reversed the G(2)-M block induced by UV, inferring a primary role for ATR in sensing this form of DNA damage.	Caffeine	0-8	ataxia telangiectasia and Rad3 related	Mus musculus	151-154
21593482-9	2011	Caffeine and KU55933 were equally effective in reversing the cisplatin-induced G(1)-S block, implicating ATM as the primary sensing enzyme.	Caffeine	0-8	ataxia telangiectasia mutated	Mus musculus	105-108
21827488-8	2011	CONCLUSIONS: The saliva paraxanthine/caffeine concentration ratio at 4h was a suitable metric to assess CYP1A2 activity after oral administration of caffeine without the need for 24-h caffeine abstinence.	Caffeine	37-45	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	104-110
21425328-10	2011	The cell growth inhibition by HMJ-30 was substantially attenuated either by the pre-incubation of U-2 OS cells with N-acetylcysteine (NAC, an antioxidant) and caffeine (an ATM kinase inhibitor) or by p53 knockdown via RNAi.	Caffeine	159-167	ATM serine/threonine kinase	Homo sapiens	172-175
21827488-8	2011	CONCLUSIONS: The saliva paraxanthine/caffeine concentration ratio at 4h was a suitable metric to assess CYP1A2 activity after oral administration of caffeine without the need for 24-h caffeine abstinence.	Caffeine	149-157	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	104-110
21827488-8	2011	CONCLUSIONS: The saliva paraxanthine/caffeine concentration ratio at 4h was a suitable metric to assess CYP1A2 activity after oral administration of caffeine without the need for 24-h caffeine abstinence.	Caffeine	149-157	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	104-110
22095868-7	2011	Many of these changes were prevented when the postovulatory aging of eggs was carried out in the presence of caffeine, which minimized the decline in IP(3)R(1) function and maintained [Ca(2+)](ER) content.	Caffeine	109-117	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	150-158
21596784-3	2011	However, the relevance of Mcm2 phosphorylation is demonstrated by the sensitivity of a strain containing alanine at these positions (mcm2(AA)) to methyl methanesulfonate (MMS) and caffeine.	Caffeine	180-188	minichromosome maintenance complex component 2	Homo sapiens	26-30
21596784-3	2011	However, the relevance of Mcm2 phosphorylation is demonstrated by the sensitivity of a strain containing alanine at these positions (mcm2(AA)) to methyl methanesulfonate (MMS) and caffeine.	Caffeine	180-188	minichromosome maintenance complex component 2	Homo sapiens	133-137
21596784-5	2011	An allele with the phosphomimetic mutations S164E and S170E (mcm2(EE)) suppresses the MMS and caffeine sensitivity caused by deficiencies in DDK function.	Caffeine	94-102	minichromosome maintenance complex component 2	Homo sapiens	61-65
21596784-8	2011	The finding that the ATP site mutant mcm2(K549R) has higher DNA binding and less ATPase than mcm2(EE), but like mcm2(AA) results in drug sensitivity, supports a model whereby a specific range of Mcm2-7 activity is required in response to MMS and caffeine.	Caffeine	246-254	minichromosome maintenance complex component 2	Homo sapiens	37-41
21596784-8	2011	The finding that the ATP site mutant mcm2(K549R) has higher DNA binding and less ATPase than mcm2(EE), but like mcm2(AA) results in drug sensitivity, supports a model whereby a specific range of Mcm2-7 activity is required in response to MMS and caffeine.	Caffeine	246-254	minichromosome maintenance complex component 2	Homo sapiens	195-201
21844338-3	2011	Ataxia telangiectasia and Rad3-related (ATR) is a replication checkpoint kinase activated by DNA stresses and is one of several targets of caffeine.	Caffeine	139-147	ataxia telangiectasia and Rad3 related	Mus musculus	0-38
21558980-7	2011	Meanwhile, caffeine reduced the myocardial apoptosis and suppressed the activation of caspase 3 during myocardial I/R.	Caffeine	11-19	caspase 3	Rattus norvegicus	86-95
21558980-8	2011	Importantly, we observed a strong poly(ADP-ribose) polymerase (PARP) activation during myocardial I/R, and caffeine administration inhibited PARP activation and attenuated the expression of PARP-related proinflammatory mediators such as inducible nitric oxide synthetase, IL-6, and TNF-alpha, all of which may be correlated with downregulated nuclear factor kappaB activity.	Caffeine	107-115	poly (ADP-ribose) polymerase 1	Rattus norvegicus	141-145
21558980-8	2011	Importantly, we observed a strong poly(ADP-ribose) polymerase (PARP) activation during myocardial I/R, and caffeine administration inhibited PARP activation and attenuated the expression of PARP-related proinflammatory mediators such as inducible nitric oxide synthetase, IL-6, and TNF-alpha, all of which may be correlated with downregulated nuclear factor kappaB activity.	Caffeine	107-115	poly (ADP-ribose) polymerase 1	Rattus norvegicus	141-145
21558980-8	2011	Importantly, we observed a strong poly(ADP-ribose) polymerase (PARP) activation during myocardial I/R, and caffeine administration inhibited PARP activation and attenuated the expression of PARP-related proinflammatory mediators such as inducible nitric oxide synthetase, IL-6, and TNF-alpha, all of which may be correlated with downregulated nuclear factor kappaB activity.	Caffeine	107-115	interleukin 6	Rattus norvegicus	272-276
21558980-8	2011	Importantly, we observed a strong poly(ADP-ribose) polymerase (PARP) activation during myocardial I/R, and caffeine administration inhibited PARP activation and attenuated the expression of PARP-related proinflammatory mediators such as inducible nitric oxide synthetase, IL-6, and TNF-alpha, all of which may be correlated with downregulated nuclear factor kappaB activity.	Caffeine	107-115	tumor necrosis factor	Rattus norvegicus	282-291
21844338-3	2011	Ataxia telangiectasia and Rad3-related (ATR) is a replication checkpoint kinase activated by DNA stresses and is one of several targets of caffeine.	Caffeine	139-147	ataxia telangiectasia and Rad3 related	Mus musculus	40-43
21526346-4	2011	Unlike etoposide, a classical topoisomerase II inhibitor, CUR-triggered G2/M phase arrest was hardly reversed by caffeine (CAFF) which is an inhibitor of activated ataxia-telangiectasia-mutated (ATM)/ATM- and Rad3-related (ATR), indicating that ATM and ATR signaling pathways may be not involved in CUR-mediated S and G2/M phase arrest in HCT116 cells.	Caffeine	113-121	ATM serine/threonine kinase	Homo sapiens	164-193
21617855-0	2011	Caffeine activates tumor suppressor PTEN in sarcoma cells.	Caffeine	0-8	phosphatase and tensin homolog	Homo sapiens	36-40
21617855-4	2011	We found that caffeine induced increased intracellular cAMP levels, PTEN activation and Akt inactivation, which together prevented proliferation of human osteosarcoma cells (MG63) and fibrosarcoma cells (HT1080).	Caffeine	14-22	phosphatase and tensin homolog	Homo sapiens	68-72
21617855-4	2011	We found that caffeine induced increased intracellular cAMP levels, PTEN activation and Akt inactivation, which together prevented proliferation of human osteosarcoma cells (MG63) and fibrosarcoma cells (HT1080).	Caffeine	14-22	AKT serine/threonine kinase 1	Homo sapiens	88-91
21617855-5	2011	PTEN knockdown by siRNA reduced the effects of caffeine on Akt inactivation in osteosarcoma cells.	Caffeine	47-55	phosphatase and tensin homolog	Homo sapiens	0-4
21617855-5	2011	PTEN knockdown by siRNA reduced the effects of caffeine on Akt inactivation in osteosarcoma cells.	Caffeine	47-55	AKT serine/threonine kinase 1	Homo sapiens	59-62
21617855-6	2011	These results indicate that the tumor suppressor PTEN signaling pathway contributes to the growth-inhibitory effect of caffeine on sarcoma cells.	Caffeine	119-127	phosphatase and tensin homolog	Homo sapiens	49-53
21621312-2	2011	In an attempt to discover additional C8 oxy substituents of caffeine that lead to potent MAO inhibition, a series of related 8-aryl- and alkyloxycaffeine analogues were synthesized and their MAO-A and -B inhibition potencies were compared to those of the 8-benzyloxycaffeines.	Caffeine	60-68	monoamine oxidase A	Homo sapiens	191-203
21526346-4	2011	Unlike etoposide, a classical topoisomerase II inhibitor, CUR-triggered G2/M phase arrest was hardly reversed by caffeine (CAFF) which is an inhibitor of activated ataxia-telangiectasia-mutated (ATM)/ATM- and Rad3-related (ATR), indicating that ATM and ATR signaling pathways may be not involved in CUR-mediated S and G2/M phase arrest in HCT116 cells.	Caffeine	113-121	ATM serine/threonine kinase	Homo sapiens	195-198
21526346-4	2011	Unlike etoposide, a classical topoisomerase II inhibitor, CUR-triggered G2/M phase arrest was hardly reversed by caffeine (CAFF) which is an inhibitor of activated ataxia-telangiectasia-mutated (ATM)/ATM- and Rad3-related (ATR), indicating that ATM and ATR signaling pathways may be not involved in CUR-mediated S and G2/M phase arrest in HCT116 cells.	Caffeine	123-127	ATM serine/threonine kinase	Homo sapiens	164-193
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	Caffeine	180-188	zinc finger homeobox 3	Rattus norvegicus	27-32
21684260-3	2011	Adding caffeine to ex vivo cultures also lengthened the circadian period in mouse liver explants from Per2::Luciferase reporter gene knockin mice, and caused a phase delay in brain slices containing the suprachiasmatic nucleus (SCN), where the central circadian clock in mammals is located.	Caffeine	7-15	period circadian clock 2	Mus musculus	102-106
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	Caffeine	180-188	ATM serine/threonine kinase	Rattus norvegicus	73-102
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	Caffeine	180-188	ATM serine/threonine kinase	Rattus norvegicus	104-107
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	Caffeine	180-188	ATM serine/threonine kinase	Rattus norvegicus	133-136
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	Caffeine	180-188	ATM serine/threonine kinase	Rattus norvegicus	133-136
21641034-10	2011	Knockdown of CaMKII expression by short-hairpin RNA resulted in increased AMPK phosphorylation by AICAR even in the presence of caffeine.	Caffeine	128-136	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	13-19
21505179-0	2011	Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.	Caffeine	0-8	checkpoint kinase 1	Mus musculus	27-31
21505179-0	2011	Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.	Caffeine	0-8	cyclin B1	Mus musculus	74-83
21505179-0	2011	Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.	Caffeine	0-8	caspase 3	Mus musculus	88-97
21505179-4	2011	The activation status of the ATR/Chk1 pathway in UVB-induced tumors and uninvolved skin was determined by quantitating phospho-Chk1 (Ser317) and induction of lethal mitosis in vivo in the presence and absence of topical caffeine treatment.	Caffeine	220-228	ataxia telangiectasia and Rad3 related	Mus musculus	29-32
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	31-39	checkpoint kinase 1	Mus musculus	73-77
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	31-39	cyclin B1	Mus musculus	153-162
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	31-39	caspase 3	Mus musculus	167-176
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	204-212	cyclin B1	Mus musculus	153-162
21505179-7	2011	We hypothesize that compared with adjacent uninvolved skin, UVB-induced skin tumors have elevated activation of, and dependence on, the ATR/Chk1 pathway long after UVB exposure has ceased and that caffeine can induce apoptosis selectively in tumors by inhibiting this pathway and promoting lethal mitosis.	Caffeine	197-205	ataxia telangiectasia and Rad3 related	Mus musculus	136-139
21152932-0	2011	Effect of a single and repeated dose of caffeine on antigen-stimulated human natural killer cell CD69 expression after high-intensity intermittent exercise.	Caffeine	40-48	CD69 molecule	Homo sapiens	97-101
21561856-5	2011	Caffeine blocked UVB-induced Chk1 phosphorylation.	Caffeine	0-8	checkpoint kinase 1	Homo sapiens	29-33
21561856-6	2011	In addition, similar to the effect of the PI3K inhibitor LY294002, caffeine also inhibited phosphorylation of AKT and up-regulation of COX-2, two critical oncogenic pathways in skin tumorigenesis.	Caffeine	67-75	AKT serine/threonine kinase 1	Homo sapiens	110-113
21561856-6	2011	In addition, similar to the effect of the PI3K inhibitor LY294002, caffeine also inhibited phosphorylation of AKT and up-regulation of COX-2, two critical oncogenic pathways in skin tumorigenesis.	Caffeine	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
21561856-9	2011	Inhibiting AKT by caffeine blocked UVB-induced COX-2 up-regulation.	Caffeine	18-26	AKT serine/threonine kinase 1	Homo sapiens	11-14
21561856-9	2011	Inhibiting AKT by caffeine blocked UVB-induced COX-2 up-regulation.	Caffeine	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21561856-10	2011	Expression of constitutively active AKT that was not inhibited by caffeine was found to protect cells from caffeine-promoted apoptosis post-UVB irradiation, indicating that AKT is an essential inhibitory target for caffeine to promote apoptosis.	Caffeine	107-115	AKT serine/threonine kinase 1	Homo sapiens	36-39
21561856-10	2011	Expression of constitutively active AKT that was not inhibited by caffeine was found to protect cells from caffeine-promoted apoptosis post-UVB irradiation, indicating that AKT is an essential inhibitory target for caffeine to promote apoptosis.	Caffeine	107-115	AKT serine/threonine kinase 1	Homo sapiens	173-176
21561856-10	2011	Expression of constitutively active AKT that was not inhibited by caffeine was found to protect cells from caffeine-promoted apoptosis post-UVB irradiation, indicating that AKT is an essential inhibitory target for caffeine to promote apoptosis.	Caffeine	107-115	AKT serine/threonine kinase 1	Homo sapiens	36-39
21561856-10	2011	Expression of constitutively active AKT that was not inhibited by caffeine was found to protect cells from caffeine-promoted apoptosis post-UVB irradiation, indicating that AKT is an essential inhibitory target for caffeine to promote apoptosis.	Caffeine	107-115	AKT serine/threonine kinase 1	Homo sapiens	173-176
21561856-12	2011	These findings indicate that in HaCaT keratinocytes, inhibiting the AKT/COX-2 pathways through an ATR-independent pathway is a critical molecular mechanism by which caffeine promotes UVB-induced apoptosis of unrepaired keratinocytes for elimination.	Caffeine	165-173	AKT serine/threonine kinase 1	Homo sapiens	68-71
21561856-12	2011	These findings indicate that in HaCaT keratinocytes, inhibiting the AKT/COX-2 pathways through an ATR-independent pathway is a critical molecular mechanism by which caffeine promotes UVB-induced apoptosis of unrepaired keratinocytes for elimination.	Caffeine	165-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
21593735-3	2011	CYP1A2 activity was determined from the paraxanthine:caffeine ratio in 194 smokers and in 118 of them who had abstained from smoking during a 4-week period.	Caffeine	53-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
21152932-3	2011	Therefore, the purpose of this study was to investigate whether small repeated doses of caffeine ingested throughout the day would elicit a similar response as one large bolus dose ingested 1 h prior to exercise on antigen-stimulated NK cell CD69 expression following strenuous intermittent exercise.	Caffeine	88-96	CD69 molecule	Homo sapiens	242-246
21561856-12	2011	These findings indicate that in HaCaT keratinocytes, inhibiting the AKT/COX-2 pathways through an ATR-independent pathway is a critical molecular mechanism by which caffeine promotes UVB-induced apoptosis of unrepaired keratinocytes for elimination.	Caffeine	165-173	ATR serine/threonine kinase	Homo sapiens	98-101
21152932-6	2011	At 1-h post-exercise, the number of antigen-stimulated CD3(-)CD56(+) cells expressing CD69 was lower on 1 x CAF compared with PLA [P &lt; 0.05; PLA: 42.0 (34.0) x 10(6) cells L(-1), 1 x CAF: 26.2 (25.0) x 10(6) cells L(-1)], with values on 1 x CAF at this time point remaining close to pre-supplement.	Caffeine	108-111	neural cell adhesion molecule 1	Homo sapiens	61-65
21152932-6	2011	At 1-h post-exercise, the number of antigen-stimulated CD3(-)CD56(+) cells expressing CD69 was lower on 1 x CAF compared with PLA [P &lt; 0.05; PLA: 42.0 (34.0) x 10(6) cells L(-1), 1 x CAF: 26.2 (25.0) x 10(6) cells L(-1)], with values on 1 x CAF at this time point remaining close to pre-supplement.	Caffeine	108-111	CD69 molecule	Homo sapiens	86-90
21152932-6	2011	At 1-h post-exercise, the number of antigen-stimulated CD3(-)CD56(+) cells expressing CD69 was lower on 1 x CAF compared with PLA [P &lt; 0.05; PLA: 42.0 (34.0) x 10(6) cells L(-1), 1 x CAF: 26.2 (25.0) x 10(6) cells L(-1)], with values on 1 x CAF at this time point remaining close to pre-supplement.	Caffeine	186-189	CD69 molecule	Homo sapiens	86-90
21152932-6	2011	At 1-h post-exercise, the number of antigen-stimulated CD3(-)CD56(+) cells expressing CD69 was lower on 1 x CAF compared with PLA [P &lt; 0.05; PLA: 42.0 (34.0) x 10(6) cells L(-1), 1 x CAF: 26.2 (25.0) x 10(6) cells L(-1)], with values on 1 x CAF at this time point remaining close to pre-supplement.	Caffeine	186-189	CD69 molecule	Homo sapiens	86-90
21152932-7	2011	1 x CAF tended to attenuate the exercise-induced increase in geometric mean fluorescence intensity of CD69 expression on antigen-stimulated CD3(-)CD56(+) cells 1-h post-exercise [P = 0.055; PLA: 141 (28)%, 1 x CAF: 119 (20)%].	Caffeine	4-7	CD69 molecule	Homo sapiens	102-106
21152932-7	2011	1 x CAF tended to attenuate the exercise-induced increase in geometric mean fluorescence intensity of CD69 expression on antigen-stimulated CD3(-)CD56(+) cells 1-h post-exercise [P = 0.055; PLA: 141 (28)%, 1 x CAF: 119 (20)%].	Caffeine	4-7	neural cell adhesion molecule 1	Homo sapiens	146-150
20801937-3	2011	NAT2 activity was determined as AFMU/ (AFMU + 1X + 1U) urinary ratio in 100 subjects using caffeine as a probe.	Caffeine	91-99	N-acetyltransferase 2	Homo sapiens	0-4
21152932-7	2011	1 x CAF tended to attenuate the exercise-induced increase in geometric mean fluorescence intensity of CD69 expression on antigen-stimulated CD3(-)CD56(+) cells 1-h post-exercise [P = 0.055; PLA: 141 (28)%, 1 x CAF: 119 (20)%].	Caffeine	210-213	CD69 molecule	Homo sapiens	102-106
21152932-8	2011	These findings suggest that although one large bolus dose of caffeine attenuated the exercise-induced increase in antigen-stimulated NK cell CD69 expression 1 h following strenuous intermittent exercise, this attenuation at no point fell below pre-supplement values and caffeine does not appear to depress NK cell CD69 expression.	Caffeine	61-69	CD69 molecule	Homo sapiens	141-145
21350862-3	2011	We showed that in larvae, sucrose attraction requires Gyc-89Db and caffeine avoidance requires Gyc-89Da.	Caffeine	67-75	Guanylyl cyclase at 89Da	Drosophila melanogaster	95-103
21152932-8	2011	These findings suggest that although one large bolus dose of caffeine attenuated the exercise-induced increase in antigen-stimulated NK cell CD69 expression 1 h following strenuous intermittent exercise, this attenuation at no point fell below pre-supplement values and caffeine does not appear to depress NK cell CD69 expression.	Caffeine	61-69	CD69 molecule	Homo sapiens	314-318
21487022-1	2011	Paroxysmal non-kinesigenic dyskinesia (PNKD) is a rare autosomal dominant movement disorder triggered by stress, fatigue or consumption of either alcohol or caffeine.	Caffeine	157-165	paroxysmal nonkinesiogenic dyskinesia	Mus musculus	39-43
21350862-8	2011	We also showed that the electrophysiological responses of a GRN to caffeine were significantly reduced in flies mutant for the atypical sGCs, suggesting that at least part of the adult behavioral defects were due to a reduced ability to detect caffeine.	Caffeine	67-75	grain	Drosophila melanogaster	60-63
21350862-8	2011	We also showed that the electrophysiological responses of a GRN to caffeine were significantly reduced in flies mutant for the atypical sGCs, suggesting that at least part of the adult behavioral defects were due to a reduced ability to detect caffeine.	Caffeine	244-252	grain	Drosophila melanogaster	60-63
21518729-8	2011	Furthermore, inhibition of ATM in U2OS cells with caffeine or depletion of ATM in MCF-7-EPI(R) with short interfering RNAs can resensitize these resistant cells to epirubicin, resulting in downregulation of E2F1 and FOXM1 expression and cell death.	Caffeine	50-58	ATM serine/threonine kinase	Homo sapiens	27-30
21333504-2	2011	The electrochemical behaviors of caffeine on Nafion-Gr modified glassy carbon electrode (Nafion-Gr/GCE) were investigated by cyclic voltammetry and differential pulse voltammetry.	Caffeine	33-41	aminomethyltransferase	Homo sapiens	99-102
21333504-3	2011	The results showed that the Nafion-Gr/GCE exhibited excellent electrocatalytic activity to caffeine.	Caffeine	91-99	aminomethyltransferase	Homo sapiens	38-41
21333504-4	2011	Caffeine can be effectively accumulated at Nafion-Gr/GCE and produce a sensitive anodic peak.	Caffeine	0-8	aminomethyltransferase	Homo sapiens	53-56
21284030-5	2011	Moreover, caffeine effectively enhanced the receptor activator of NF-kappaB ligand (RANKL), but reduced the osteoprotegerin protein expressions in osteoblast MC3T3-E1 cells.	Caffeine	10-18	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	44-82
21284030-5	2011	Moreover, caffeine effectively enhanced the receptor activator of NF-kappaB ligand (RANKL), but reduced the osteoprotegerin protein expressions in osteoblast MC3T3-E1 cells.	Caffeine	10-18	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	84-89
21284030-5	2011	Moreover, caffeine effectively enhanced the receptor activator of NF-kappaB ligand (RANKL), but reduced the osteoprotegerin protein expressions in osteoblast MC3T3-E1 cells.	Caffeine	10-18	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	108-123
21284030-6	2011	Caffeine could also increase the cyclooxygenase-2 (COX-2) protein expression and prostaglandin (PG)E(2) production in cultured neonatal mouse calvariae.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	33-49
21284030-6	2011	Caffeine could also increase the cyclooxygenase-2 (COX-2) protein expression and prostaglandin (PG)E(2) production in cultured neonatal mouse calvariae.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	51-56
21284030-11	2011	Caffeine may possess the ability to enhance a COX-2/PGE(2) -regulated RANKL-mediated osteoclastogenesis.	Caffeine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	46-51
21284030-11	2011	Caffeine may possess the ability to enhance a COX-2/PGE(2) -regulated RANKL-mediated osteoclastogenesis.	Caffeine	0-8	TNF superfamily member 11	Rattus norvegicus	70-75
21295028-11	2011	Interestingly, caffeine was the most promising drug candidate for therapeutic intervention with high efficacy in both APP (77%) and tau-induced models (72% recovery).	Caffeine	15-23	microtubule associated protein tau	Homo sapiens	132-135
21589943-8	2011	Functionally, cardiomyocytes derived from the apoA-I-transduced cells exhibited improved calcium handling properties in both non-caffeine and caffeine-induced calcium transient, suggesting that apoA-I plays a role in enhancing cardiac maturation.	Caffeine	129-137	apolipoprotein A1	Homo sapiens	46-52
21357676-7	2011	CYP1A2 is the main caffeine metabolizing enzyme and is also involved in drug metabolism.	Caffeine	19-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
21493892-8	2011	(3) Hearts from hdp(2) mutants had reductions in caffeine-induced Ca(2+) increases and reductions in ryanodine receptor (RyR) without changes in L-type Ca(2+) channel transcripts in comparison with w(1118).	Caffeine	49-57	wings up A	Drosophila melanogaster	16-22
21589943-8	2011	Functionally, cardiomyocytes derived from the apoA-I-transduced cells exhibited improved calcium handling properties in both non-caffeine and caffeine-induced calcium transient, suggesting that apoA-I plays a role in enhancing cardiac maturation.	Caffeine	129-137	apolipoprotein A1	Homo sapiens	194-200
21589943-8	2011	Functionally, cardiomyocytes derived from the apoA-I-transduced cells exhibited improved calcium handling properties in both non-caffeine and caffeine-induced calcium transient, suggesting that apoA-I plays a role in enhancing cardiac maturation.	Caffeine	142-150	apolipoprotein A1	Homo sapiens	46-52
21589943-8	2011	Functionally, cardiomyocytes derived from the apoA-I-transduced cells exhibited improved calcium handling properties in both non-caffeine and caffeine-induced calcium transient, suggesting that apoA-I plays a role in enhancing cardiac maturation.	Caffeine	142-150	apolipoprotein A1	Homo sapiens	194-200
21371533-6	2011	Hippocampal CA1 pyramidal neurons treated with caffeine or UA were resistant to oxidant exposure in the slice culture experiments.	Caffeine	47-55	carbonic anhydrase 1	Mus musculus	12-15
21371533-9	2011	Immunohistochemical analysis showed increased GSH levels in the hippocampal excitatory amino acid carrier-1 (EAAC1)-positive neurons of mice treated with caffeine or UA.	Caffeine	154-162	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	76-107
21371533-9	2011	Immunohistochemical analysis showed increased GSH levels in the hippocampal excitatory amino acid carrier-1 (EAAC1)-positive neurons of mice treated with caffeine or UA.	Caffeine	154-162	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	109-114
20595055-2	2011	The crystallographic model of the human adenosine A(2A) receptor was recently solved to 2.6A in complex with the antagonist ZM241385, which is also referred to as "super-caffeine" because of its strong antagonistic effect on adenosine receptors.	Caffeine	170-178	adenosine A2a receptor	Homo sapiens	40-64
21336968-4	2011	The Chk1-specific inhibitor, UCN-01, and the ATR inhibitor, Caffeine, cause neuronal apoptosis in differentiated neurons in the absence of additional treatment, whereas inhibition of ATM or Chk2, does not.	Caffeine	60-68	ATR serine/threonine kinase	Homo sapiens	45-48
21132546-8	2011	Caffeine supplementation and exercise increased the concentration of catecholamines, salivary alpha-amylase and total protein, whilst the salivary Hsp72:alpha-amylase ratio was lower in CAF.	Caffeine	0-8	amylase alpha 1A	Homo sapiens	85-107
21424556-8	2011	However, pharmacological inhibition of ATM using KU55933 and caffeine suggests that ATM inhibition by ROSC is not the only mechanism that might explain the anti-apoptotic effects of this drug in this apoptosis model.	Caffeine	61-69	ATM serine/threonine kinase	Homo sapiens	39-42
21281405-0	2011	Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson"s disease.	Caffeine	33-41	adenosine A2a receptor	Homo sapiens	8-15
21281405-0	2011	Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson"s disease.	Caffeine	33-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
21281405-1	2011	BACKGROUND AND PURPOSE: In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson"s disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A).	Caffeine	115-123	adenosine A2a receptor	Homo sapiens	157-179
21281405-1	2011	BACKGROUND AND PURPOSE: In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson"s disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A).	Caffeine	115-123	adenosine A2a receptor	Homo sapiens	181-188
21281405-2	2011	Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-56
21281405-2	2011	Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-64
21281405-11	2011	In contrast, the coffee-PD association was strongest among slow metabolizers of caffeine who were homozygous carriers of the CYP1A2 polymorphisms.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	alpha fetoprotein	Mus musculus	116-133
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	alpha fetoprotein	Mus musculus	135-138
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	C-reactive protein, pentraxin-related	Mus musculus	141-159
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	C-reactive protein, pentraxin-related	Mus musculus	161-164
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	glutamic pyruvic transaminase, soluble	Mus musculus	175-199
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	glutamic pyruvic transaminase, soluble	Mus musculus	201-204
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	244-254
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	interleukin 1 alpha	Mus musculus	257-275
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	interleukin 1 alpha	Mus musculus	277-286
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	interleukin 1 beta	Mus musculus	289-297
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	313-346
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	348-353
21352949-8	2011	Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver.	Caffeine	10-18	glutamic pyruvic transaminase, soluble	Mus musculus	55-58
21352949-8	2011	Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver.	Caffeine	10-18	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	60-70
21352949-8	2011	Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver.	Caffeine	10-18	interleukin 1 alpha	Mus musculus	72-81
21352949-8	2011	Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver.	Caffeine	10-18	interleukin 1 beta	Mus musculus	86-94
21533241-6	2011	In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models.	Caffeine	119-127	period circadian regulator 2	Homo sapiens	44-48
21324902-4	2011	These cells required caffeine-sensitive Mec1 kinase-dependent checkpoint signaling for survival even in the absence of extrinsically induced genotoxic stress.	Caffeine	21-29	protein kinase MEC1	Saccharomyces cerevisiae S288C	40-44
21338685-5	2011	However, chronic caffeine treatment prevented the effect of sleep-deprivation on the stimulated levels of P-CREB and BDNF.	Caffeine	17-25	brain-derived neurotrophic factor	Rattus norvegicus	117-121
21558577-4	2011	A high dose of caffeine (6CAF) increased the number of CD3-CD56+ cells in the circulation immediately postexercise compared with PLA (p &lt; .05).	Caffeine	15-23	neural cell adhesion molecule 1	Homo sapiens	59-63
21533241-6	2011	In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models.	Caffeine	119-127	clock circadian regulator	Homo sapiens	30-35
21533241-6	2011	In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models.	Caffeine	119-127	neuronal PAS domain protein 2	Homo sapiens	37-42
21533241-6	2011	In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models.	Caffeine	119-127	period circadian regulator 3	Homo sapiens	54-58
21335533-4	2011	The sch9 hyperfilamentous phenotype was independent of Rim15 kinase and was recreated by inhibition of Tor1 kinase by rapamycin or caffeine in a wild-type strain, suggesting that Sch9 suppression requires Tor1.	Caffeine	131-139	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	4-8
21335533-4	2011	The sch9 hyperfilamentous phenotype was independent of Rim15 kinase and was recreated by inhibition of Tor1 kinase by rapamycin or caffeine in a wild-type strain, suggesting that Sch9 suppression requires Tor1.	Caffeine	131-139	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	179-183
21335533-5	2011	Caffeine inhibition also revealed that both protein kinase A isoforms, as well as transcription factors Czf1 and Ace2, are required to generate the sch9 mutant phenotype.	Caffeine	0-8	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	148-152
21346110-2	2011	infusions, and caffeine-induced insulin resistance, with alkaloid caffeine.	Caffeine	15-23	insulin	Homo sapiens	32-39
21338685-3	2011	The results showed that chronic caffeine treatment prevented the impairment of long-term memory as measured by performance in the radial arm water maze task and normalized L-LTP in area CA1 of the hippocampi of sleep-deprived anesthetized rats.	Caffeine	32-40	carbonic anhydrase 1	Rattus norvegicus	186-189
21338685-6	2011	The results suggest that chronic caffeine treatment may protect the sleep-deprived brain probably by preserving the levels of P-CREB and BDNF.	Caffeine	33-41	brain-derived neurotrophic factor	Rattus norvegicus	137-141
21409566-6	2011	Oca1, Oca2, Siw14/Oca3, Oca4, and Oca6 were involved in the yeast response to caffeine and rapamycin stresses.	Caffeine	78-86	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	12-17
21409566-8	2011	Remarkably, overexpression of Siw14/Oca3 suppressed the caffeine sensitivity of oca1, oca2, oca4, and oca6 deleted strains, indicating a genetic linkage and suggesting a functional relationship for these proteins.	Caffeine	56-64	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	30-35
21212417-4	2011	MCF-7 cells treated with EGF, ATP, extracellular calcium, or caffeine to increase intracellular calcium triggered a rapid recruitment of ERalpha to estrogen-responsive promoters and stimulated expression of estrogen-responsive genes including pS2, complement C3, and progesterone receptor.	Caffeine	61-69	estrogen receptor 1	Homo sapiens	137-144
21483779-6	2011	The presence of a functional ryanodine receptor (RyR)-mediated sarcoplasmic reticulum (SR) Ca(2+) store, contributing to [Ca(2+)](i) transients, was established by application of caffeine (triggering a rapid increase in cytosolic Ca(2+)) and ryanodine (decreasing [Ca(2+)](i)).	Caffeine	179-187	ryanodine receptor 2	Homo sapiens	49-52
21490707-0	2011	Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.	Caffeine	106-114	H3 histone pseudogene 16	Homo sapiens	49-52
21490707-0	2011	Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.	Caffeine	106-114	aryl hydrocarbon receptor	Homo sapiens	54-57
21490707-0	2011	Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.	Caffeine	106-114	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
21490707-4	2011	Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.	Caffeine	90-98	aryl hydrocarbon receptor	Homo sapiens	9-12
21490707-4	2011	Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
21490707-4	2011	Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
21490707-4	2011	Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.	Caffeine	90-98	aryl hydrocarbon receptor	Homo sapiens	103-106
21490707-4	2011	Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
21334631-7	2011	The method limits of detection ranged from 0.1 ngL(-1) for compounds including cocaine, benzoylecgonine, norbenzoylecgonine and 2-oxo-3-hydroxy-LSD to 100 ngL(-1) for caffeine.	Caffeine	167-175	leucine rich repeat containing 4C	Homo sapiens	155-161
21238452-0	2011	Chronic or high dose acute caffeine treatment protects mice against oleic acid-induced acute lung injury via an adenosine A2A receptor-independent mechanism.	Caffeine	27-35	adenosine A2a receptor	Mus musculus	112-134
21212417-4	2011	MCF-7 cells treated with EGF, ATP, extracellular calcium, or caffeine to increase intracellular calcium triggered a rapid recruitment of ERalpha to estrogen-responsive promoters and stimulated expression of estrogen-responsive genes including pS2, complement C3, and progesterone receptor.	Caffeine	61-69	taste 2 receptor member 64 pseudogene	Homo sapiens	243-246
21212417-4	2011	MCF-7 cells treated with EGF, ATP, extracellular calcium, or caffeine to increase intracellular calcium triggered a rapid recruitment of ERalpha to estrogen-responsive promoters and stimulated expression of estrogen-responsive genes including pS2, complement C3, and progesterone receptor.	Caffeine	61-69	complement C3	Homo sapiens	248-261
21212417-4	2011	MCF-7 cells treated with EGF, ATP, extracellular calcium, or caffeine to increase intracellular calcium triggered a rapid recruitment of ERalpha to estrogen-responsive promoters and stimulated expression of estrogen-responsive genes including pS2, complement C3, and progesterone receptor.	Caffeine	61-69	progesterone receptor	Homo sapiens	267-288
21325885-6	2011	A late, permanent and ATM-independent arrest (&gt;=6 hours after IR) of cells that were in G(2)/S/G(1) at the time of irradiation (4 Gy) was inactivated by caffeine.	Caffeine	156-164	ATM serine/threonine kinase	Homo sapiens	22-25
21237705-1	2011	A Saccharomyces cerevisiae mutant lacking PPZ1, encoding a serine/threonine protein phosphatase (PPase), is caffeine-sensitive.	Caffeine	108-116	salt homeostasis regulator	Saccharomyces cerevisiae S288C	42-46
21347609-0	2011	Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements.	Caffeine	45-53	checkpoint kinase 1	Homo sapiens	172-176
21237705-2	2011	To clarify the function of Ppz1 in resistance to caffeine, we attempted systematically to identify protein kinase (PKase) whose disruption lead to suppression of caffeine sensitive phenotype of the  ppz1 disruptant since disruption of PPZ1 might cause caffeine sensitivity by increasing its phosphorylated substrates and we presumed that disruption of genes for PKase sharing the substrate with Ppz1 could restore the resistance through bypassing necessity for dephosphorylation of substrates.	Caffeine	162-170	salt homeostasis regulator	Saccharomyces cerevisiae S288C	199-203
21237705-2	2011	To clarify the function of Ppz1 in resistance to caffeine, we attempted systematically to identify protein kinase (PKase) whose disruption lead to suppression of caffeine sensitive phenotype of the  ppz1 disruptant since disruption of PPZ1 might cause caffeine sensitivity by increasing its phosphorylated substrates and we presumed that disruption of genes for PKase sharing the substrate with Ppz1 could restore the resistance through bypassing necessity for dephosphorylation of substrates.	Caffeine	162-170	salt homeostasis regulator	Saccharomyces cerevisiae S288C	199-203
21237705-3	2011	Among the 102 viable pkase disruptions, disruption of either SAT4 or HAL5 suppressed the caffeine sensitivity phenotype and increased expression of ENA1, encoding a P-type ATPase of the  ppz1 disruptant.	Caffeine	89-97	serine/threonine protein kinase SAT4	Saccharomyces cerevisiae S288C	61-65
21237705-3	2011	Among the 102 viable pkase disruptions, disruption of either SAT4 or HAL5 suppressed the caffeine sensitivity phenotype and increased expression of ENA1, encoding a P-type ATPase of the  ppz1 disruptant.	Caffeine	89-97	protein kinase HAL5	Saccharomyces cerevisiae S288C	69-73
21882652-4	2011	Three drugs, caffeine, norfloxacin and nimesulide, were used for this study to see the effect mainly the hatching rate of eggs, heart beat rate and the vascular endothelial growth factor (VEGF) expression of the larvae.	Caffeine	13-21	vascular endothelial growth factor Aa	Danio rerio	188-192
24761260-0	2011	Caffeine, Alcohol, and Youth: A Toxic Mix.	Caffeine	0-8	Mix paired-like homeobox	Homo sapiens	38-41
21882652-14	2011	Expression of VEGF was very low in caffeine treated group.	Caffeine	35-43	vascular endothelial growth factor Aa	Danio rerio	14-18
20838929-0	2011	Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	51-54
20838929-4	2011	We show that caffeine blocks the cell cycle at G1 phase in neuroblastoma cells and leads to a decrease in tau phosphorylation; similarly, exposure of postmitotic neurons to caffeine led to changes in tau phosphorylation concomitantly with downregulation of Akt signaling.	Caffeine	13-21	AKT serine/threonine kinase 1	Homo sapiens	257-260
20838929-4	2011	We show that caffeine blocks the cell cycle at G1 phase in neuroblastoma cells and leads to a decrease in tau phosphorylation; similarly, exposure of postmitotic neurons to caffeine led to changes in tau phosphorylation concomitantly with downregulation of Akt signaling.	Caffeine	173-181	AKT serine/threonine kinase 1	Homo sapiens	257-260
21241457-7	2011	RESULTS: Incubation of isolated epitrochlearis muscle with 1 mm of caffeine for 15 min increased AMPKalpha1 activity, but not AMPKalpha2 activity; concentrations of ATP, PCr and glycogen were not affected.	Caffeine	67-75	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	97-107
21308861-5	2011	Models using specific PIK kinase inhibitors, somatic cell gene targeting, and RNA interference demonstrated that the observed detrimental effects of caffeine on CSC were attributable specifically to the inhibition of the PIK kinase ataxia telangiectasia- and Rad3-related (ATR).	Caffeine	149-157	ATR serine/threonine kinase	Homo sapiens	232-271
21308861-5	2011	Models using specific PIK kinase inhibitors, somatic cell gene targeting, and RNA interference demonstrated that the observed detrimental effects of caffeine on CSC were attributable specifically to the inhibition of the PIK kinase ataxia telangiectasia- and Rad3-related (ATR).	Caffeine	149-157	ATR serine/threonine kinase	Homo sapiens	273-276
21359089-1	2011	STUDY OBJECTIVES: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.	Caffeine	116-124	adenosine deaminase	Homo sapiens	58-77
21070747-9	2011	Cynomolgus monkey CYP1D1 protein heterologously expressed in Escherichia coli catalyzed ethoxyresorufin O-deethylation and caffeine 8-hydroxylation, which CYP1As also catalyze.	Caffeine	123-131	cytochrome P450 family 1 subfamily D member 1	Macaca fascicularis	18-24
21081844-0	2011	Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	64-67
21081844-0	2011	Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.	Caffeine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	68-72
21081844-0	2011	Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.	Caffeine	0-8	ribosomal protein S6 kinase B1	Homo sapiens	73-79
21081844-2	2011	All known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction.	Caffeine	45-53	tumor protein p53	Homo sapiens	91-94
21081844-5	2011	Phosphorylated p70 ribosomal protein S6 kinase (Thr389), S6 ribosomal protein (Ser235/236), 4E-BP1 (Thr37/46) and Akt (Ser473) were significantly decreased by caffeine.	Caffeine	159-167	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	92-98
21081844-6	2011	In contrast, ERK1/2 (Thr202/204) was increased by caffeine, suggesting an inhibition of the Akt/mTOR/p70S6K pathway and activation of the ERK1/2 pathway.	Caffeine	50-58	mitogen-activated protein kinase 3	Homo sapiens	13-19
21081844-6	2011	In contrast, ERK1/2 (Thr202/204) was increased by caffeine, suggesting an inhibition of the Akt/mTOR/p70S6K pathway and activation of the ERK1/2 pathway.	Caffeine	50-58	AKT serine/threonine kinase 1	Homo sapiens	92-95
21081844-6	2011	In contrast, ERK1/2 (Thr202/204) was increased by caffeine, suggesting an inhibition of the Akt/mTOR/p70S6K pathway and activation of the ERK1/2 pathway.	Caffeine	50-58	mechanistic target of rapamycin kinase	Homo sapiens	96-100
21081844-6	2011	In contrast, ERK1/2 (Thr202/204) was increased by caffeine, suggesting an inhibition of the Akt/mTOR/p70S6K pathway and activation of the ERK1/2 pathway.	Caffeine	50-58	ribosomal protein S6 kinase B1	Homo sapiens	101-107
21081844-6	2011	In contrast, ERK1/2 (Thr202/204) was increased by caffeine, suggesting an inhibition of the Akt/mTOR/p70S6K pathway and activation of the ERK1/2 pathway.	Caffeine	50-58	mitogen-activated protein kinase 3	Homo sapiens	138-144
21081844-7	2011	Although insulin treatment phosphorylated Akt (Ser473) and led to autophagy suppression, the effect of insulin treatment was completely abolished by caffeine addition.	Caffeine	149-157	insulin	Homo sapiens	103-110
21081844-9	2011	Caffeine induced reduction of mitochondrial membrane potentials and apoptosis in a dose-dependent manner, which was further attenuated by the inhibition of autophagy with 3-methyladenine or Atg7 siRNA knockdown.	Caffeine	0-8	autophagy related 7	Homo sapiens	190-194
21229324-0	2011	Caffeine inhibits cell proliferation and regulates PKA/GSK3beta pathways in U87MG human glioma cells.	Caffeine	0-8	glycogen synthase kinase 3 beta	Homo sapiens	55-63
21229324-4	2011	In addition, caffeine induced apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage.	Caffeine	13-21	caspase 3	Homo sapiens	48-57
21229324-4	2011	In addition, caffeine induced apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage.	Caffeine	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	73-100
21229324-4	2011	In addition, caffeine induced apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage.	Caffeine	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	102-106
21229324-5	2011	Caffeine also phosphorylated serine 9 of glycogen synthase kinase 3 beta (GSK3beta).	Caffeine	0-8	glycogen synthase kinase 3 beta	Homo sapiens	41-72
21229324-5	2011	Caffeine also phosphorylated serine 9 of glycogen synthase kinase 3 beta (GSK3beta).	Caffeine	0-8	glycogen synthase kinase 3 beta	Homo sapiens	74-82
21229324-6	2011	Pretreatment with H89, a pharmacological inhibitor of protein kinase A (PKA), was able to antagonize caffeine-induced GSK3beta(ser9) phosphorylation, suggesting that the mechanism might involve a cAMP-dependent PKA-dependent pathway.	Caffeine	101-109	glycogen synthase kinase 3 beta	Homo sapiens	118-126
21360731-0	2011	Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae.	Caffeine	120-128	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	38-42
21360731-2	2011	Here we report that the genes HSE1, RTS3, SDS23 and SDS24 confer caffeine resistance when overexpressed in S. cerevisiae.	Caffeine	65-73	ESCRT-0 subunit protein HSE1	Saccharomyces cerevisiae S288C	30-34
21360731-2	2011	Here we report that the genes HSE1, RTS3, SDS23 and SDS24 confer caffeine resistance when overexpressed in S. cerevisiae.	Caffeine	65-73	Rts3p	Saccharomyces cerevisiae S288C	36-40
21360731-2	2011	Here we report that the genes HSE1, RTS3, SDS23 and SDS24 confer caffeine resistance when overexpressed in S. cerevisiae.	Caffeine	65-73	Sds23p	Saccharomyces cerevisiae S288C	42-47
21360731-2	2011	Here we report that the genes HSE1, RTS3, SDS23 and SDS24 confer caffeine resistance when overexpressed in S. cerevisiae.	Caffeine	65-73	Sds24p	Saccharomyces cerevisiae S288C	52-57
21360731-8	2011	Epistasis experiments support a model in which Rts3 and Sds23/24 act in parallel to negatively regulate Sit4, while Hse1 confers caffeine resistance via a separate pathway.	Caffeine	129-137	ESCRT-0 subunit protein HSE1	Saccharomyces cerevisiae S288C	116-120
21360731-9	2011	In summary, this study identifies the Sit4 phosphatase pathway and membrane protein dynamics as key modulators of caffeine-mediated inhibition of yeast cell growth and proposes novel functions for Rts3 and Sds23/24.	Caffeine	114-122	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	38-42
21360731-9	2011	In summary, this study identifies the Sit4 phosphatase pathway and membrane protein dynamics as key modulators of caffeine-mediated inhibition of yeast cell growth and proposes novel functions for Rts3 and Sds23/24.	Caffeine	114-122	Rts3p	Saccharomyces cerevisiae S288C	197-201
21360731-9	2011	In summary, this study identifies the Sit4 phosphatase pathway and membrane protein dynamics as key modulators of caffeine-mediated inhibition of yeast cell growth and proposes novel functions for Rts3 and Sds23/24.	Caffeine	114-122	Sds23p	Saccharomyces cerevisiae S288C	206-211
21320437-1	2011	Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	113-117
21320437-1	2011	Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel.	Caffeine	10-35	ryanodine receptor 2	Homo sapiens	113-117
21320437-3	2011	Here, the action of caffeine on single RyR2 channels in bilayers and Ca(2+) sparks in permeabilized ventricular cardiomyocytes is defined.	Caffeine	20-28	ryanodine receptor 2	Homo sapiens	39-43
21320437-4	2011	Single RyR2 caffeine activation depended on the free Ca(2+) level on both sides of the channel.	Caffeine	12-20	ryanodine receptor 2	Homo sapiens	7-11
21320437-6	2011	Caffeine activated single RyR2 channels in diastolic quasi-cell-like solutions (cytosolic MgATP, pCa 7) with an EC(50) of 9.0 +- 0.4 mM.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	26-30
21241457-2	2011	Skeletal muscle expresses two catalytic alpha subunits of AMPK, alpha1 and alpha2, but the isoform specificity of caffeine-induced AMPK activation is unclear.	Caffeine	114-122	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	58-62
21241457-2	2011	Skeletal muscle expresses two catalytic alpha subunits of AMPK, alpha1 and alpha2, but the isoform specificity of caffeine-induced AMPK activation is unclear.	Caffeine	114-122	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	131-135
21241457-9	2011	Incubation with 1 mm of caffeine increased the phosphorylation of AMPK and ACC and enhanced 3MG transport.	Caffeine	24-32	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	66-70
21241457-10	2011	Intravenous injection of caffeine (5 mg kg(-1) ) predominantly activated AMPKalpha1 and increased 3MG transport without affecting energy status.	Caffeine	25-33	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	73-83
21241457-11	2011	CONCLUSION: Our results suggest that of the two alpha isoforms of AMPK, AMPKalpha1 is predominantly activated by caffeine via an energy-independent mechanism and that the activation of AMPKalpha1 increases glucose transport and ACC phosphorylation in skeletal muscle.	Caffeine	113-121	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	66-70
21241457-11	2011	CONCLUSION: Our results suggest that of the two alpha isoforms of AMPK, AMPKalpha1 is predominantly activated by caffeine via an energy-independent mechanism and that the activation of AMPKalpha1 increases glucose transport and ACC phosphorylation in skeletal muscle.	Caffeine	113-121	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	72-82
21241457-11	2011	CONCLUSION: Our results suggest that of the two alpha isoforms of AMPK, AMPKalpha1 is predominantly activated by caffeine via an energy-independent mechanism and that the activation of AMPKalpha1 increases glucose transport and ACC phosphorylation in skeletal muscle.	Caffeine	113-121	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	185-195
21461241-11	2011	In permeabilized INS-1 cells, Ca(2+) release from internal stores was activated by caffeine, Ca(2+), or ryanodine.	Caffeine	83-91	insulin 1	Rattus norvegicus	17-22
21411838-1	2011	CONTEXT: Carbohydrate (CHO) and caffeine (CAF) both improve endurance performance.	Caffeine	32-40	lysine acetyltransferase 2B	Homo sapiens	42-45
22146708-5	2011	The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group.	Caffeine	175-183	mast cell protease 1	Mus musculus	63-68
21097658-11	2011	Insomnia subjects, but not good sleepers, showed increased concentrations of IL-6 associated with caffeine use.	Caffeine	98-106	interleukin 6	Homo sapiens	77-81
20888899-7	2011	Unexpectedly, in BaP-treated HeLa cells, caffeine pretreatment did not inhibit but rather increased gammaH2AX level.	Caffeine	41-49	H2A.X variant histone	Mus musculus	100-109
20888899-8	2011	On the other hand, caffeine or wortmannin can inhibit BaP-induced gammaH2AX in either U2OS, DNA-PKcs(-/-) or ATM(-/-) cells.	Caffeine	19-27	H2A.X variant histone	Mus musculus	66-75
20888899-8	2011	On the other hand, caffeine or wortmannin can inhibit BaP-induced gammaH2AX in either U2OS, DNA-PKcs(-/-) or ATM(-/-) cells.	Caffeine	19-27	ATM serine/threonine kinase	Homo sapiens	109-112
21036123-6	2011	Caffeine did not affect cortical spreading depression, but antagonized latent inhibition in both the RBD(8)-malnourished rats and in the well-nourished control group fed a chow diet with 22% protein.	Caffeine	0-8	calcium voltage-gated channel subunit alpha1 D	Rattus norvegicus	101-104
21468923-5	2011	The areas under the curve of both caffeine and its three major metabolites (paraxanthine, theophylline, and theobromine) were significantly reduced by rutaecarpine, indicating that caffeine was rapidly converted into the desmethylated metabolites, and that those were also quickly transformed into further metabolites via the hydroxyl metabolites due to the remarkable induction of CYP1A2 and 2E1.	Caffeine	34-42	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	382-388
21468923-5	2011	The areas under the curve of both caffeine and its three major metabolites (paraxanthine, theophylline, and theobromine) were significantly reduced by rutaecarpine, indicating that caffeine was rapidly converted into the desmethylated metabolites, and that those were also quickly transformed into further metabolites via the hydroxyl metabolites due to the remarkable induction of CYP1A2 and 2E1.	Caffeine	181-189	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	382-388
22146708-5	2011	The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group.	Caffeine	175-183	interleukin 6	Mus musculus	73-77
21211004-6	2011	RESULTS: The increase in adenosine levels tended to be more pronounced in the subjects heterozygous for the AMPD1 34C &gt; T variant (71 +- 22%, P=0.04), compared to placebo- (59 +- 29%, P=0.012) and caffeine-treated (53 +- 47%, P=0.29) subjects, but this difference between groups did not reach statistical significance.	Caffeine	200-208	adenosine monophosphate deaminase 1	Homo sapiens	108-113
21766341-5	2011	The highest solubility ratio of 1:40 (theophylline:caffeine) was observed in the SCF with 20% acetonitrile (MeCN), where a ratio of 1:11 was the highest in the neat organic solvents.	Caffeine	51-59	KIT ligand	Homo sapiens	81-84
21766341-7	2011	The SCF with 20% MeCN selectively removed caffeine and left theophylline largely intact.	Caffeine	42-50	KIT ligand	Homo sapiens	4-7
21322095-3	2011	The kinetic studies performed in this work showed that caffeine inhibition of bovine serum amine oxidase was noncompetitive when benzylamine was used as substrate and mixed when the substrate used was methylamine.	Caffeine	55-63	primary amine oxidase, liver isozyme	Bos taurus	85-104
20859794-3	2011	All known PDE inhibitors contain one or more rings that mimic the purine in the cN substrate and directly compete with cN for access to the catalytic site; this review focuses on inhibitors that contain a nucleus that is closely related to the xanthine ring of theophylline and caffeine and the purine ring of cNs.	Caffeine	278-286	aldehyde dehydrogenase 7 family member A1	Homo sapiens	10-13
20859805-6	2011	Caffeine and theophylline stimulate the secretion of renin by inhibition of adenosine receptors and removal of the general inhibitory brake function of endogenous adenosine.	Caffeine	0-8	renin	Homo sapiens	53-58
20859811-3	2011	There is a paradox as consumption of either caffeine or caffeinated coffee results in a marked insulin resistance and yet habitual coffee consumption has repeatedly been reported to markedly reduce the risk for type 2 diabetes.	Caffeine	44-52	insulin	Homo sapiens	95-102
20859811-4	2011	There is strong evidence that caffeine reduces insulin sensitivity in skeletal muscle and this may be due to a combination of direct antagonism of A(1) receptors and indirectly beta-adrenergic stimulation as a result of increased sympathetic activity.	Caffeine	30-38	insulin	Homo sapiens	47-54
22272088-0	2011	Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells.	Caffeine	0-8	REV3 like, DNA directed polymerase zeta catalytic subunit	Mus musculus	43-47
21030499-0	2011	Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women.	Caffeine	11-19	sex hormone binding globulin	Homo sapiens	47-75
21631964-4	2011	Inhibition of ATM by caffeine delayed mitoxantrone-induced cell death in MOLT-4 cells.	Caffeine	21-29	ATM serine/threonine kinase	Homo sapiens	14-17
21631964-9	2011	2) ATM inhibition by caffeine prevents G2 cell arrest and in p53-positive cells MOLT-4 delays the onset of mitoxantrone-induced cell death.	Caffeine	21-29	ATM serine/threonine kinase	Homo sapiens	3-6
21422521-0	2011	Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer"s mice.	Caffeine	0-8	colony stimulating factor 3 (granulocyte)	Mus musculus	69-73
21422521-8	2011	Since we have previously reported that long-term GCSF treatment enhances cognitive performance in AD mice through three possible mechanisms (e.g., recruitment of microglia from bone marrow, synaptogenesis, and neurogenesis), the same mechanisms could be complimentary to caffeine"s established ability to suppress Abeta production.	Caffeine	271-279	colony stimulating factor 3 (granulocyte)	Mus musculus	49-53
21422521-9	2011	We conclude that coffee may be the best source of caffeine to protect against AD because of a component in coffee that synergizes with caffeine to enhance plasma GCSF levels, resulting in multiple therapeutic actions against AD.	Caffeine	50-58	colony stimulating factor 3 (granulocyte)	Mus musculus	162-166
21422521-9	2011	We conclude that coffee may be the best source of caffeine to protect against AD because of a component in coffee that synergizes with caffeine to enhance plasma GCSF levels, resulting in multiple therapeutic actions against AD.	Caffeine	135-143	colony stimulating factor 3 (granulocyte)	Mus musculus	162-166
21995906-8	2011	Caffeine-treated rats exhibited transient changes: single responses were augmented in P25 if high stimulation intensity was used, paired-pulse and frequency responses were higher in experimental than in control animals at P12, the opposite change was observed in 18- and more markedly in 25-day-old rats.	Caffeine	0-8	lipocalin 2	Rattus norvegicus	86-89
22272088-3	2011	In human cancer cells or xeroderma pigmentosum variant (XP-V) cells, UV-TLS was inhibited by caffeine or proteasome inhibitors.	Caffeine	93-101	DNA polymerase eta	Homo sapiens	56-60
22272088-3	2011	In human cancer cells or xeroderma pigmentosum variant (XP-V) cells, UV-TLS was inhibited by caffeine or proteasome inhibitors.	Caffeine	93-101	FUS RNA binding protein	Homo sapiens	72-75
22272088-7	2011	In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells), and was abolished by caffeine or MG-262.	Caffeine	114-122	E74 like ETS transcription factor 4	Homo sapiens	17-20
22272088-7	2011	In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells), and was abolished by caffeine or MG-262.	Caffeine	114-122	FUS RNA binding protein	Homo sapiens	25-28
22272088-12	2011	Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.	Caffeine	139-147	REV3 like, DNA directed polymerase zeta catalytic subunit	Mus musculus	97-101
20971118-7	2011	However nickel decreased the rate constant of the caffeine-induced Ca transient in control and detubulated cells, although its effect was greater in control cells, suggesting that Ca extrusion via NCX occurs across the surface and t-tubule membranes.	Caffeine	50-58	solute carrier family 8 member A1	Rattus norvegicus	197-200
21733412-10	2011	The rank order of these drugs potencies to up-regulate P-gp activity was as following: hyperforin &gt;&gt;&gt; dexamethasone ~ beta-estradiol &gt; caffeine &gt; rifampicin ~ pentylenetetrazole &gt; verapamil.	Caffeine	147-155	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
20927050-0	2011	Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Delta9-tetrahydrocannabinol on spatial memory.	Caffeine	97-105	cannabinoid receptor 1 (brain)	Mus musculus	38-41
22039534-7	2011	However, with luminal Ba(2+)or Mg(2+), RyR2 were less sensitive to cytosolic Ca(2+) and caffeine-mediated activation, openings were shorter and voltage-dependence was more marked (compared to RyR2 with luminal Ca(2+)or Sr(2+)).	Caffeine	88-96	ryanodine receptor 2	Sus scrofa	39-43
22164264-14	2011	CONCLUSIONS/SIGNIFICANCE: These data show that caffeine alters embryonic cardiac function and disrupts the normal cardiac response to hypoxia through blockade of A1AR action.	Caffeine	47-55	adenosine A1 receptor	Mus musculus	162-166
21912625-5	2011	rs11136000 at the CLU locus was associated with PD risk under the recessive model (comparing TT versus CC+CT: OR = 0.71, 95% CI: 0.55-0.92, p = 0.008) after adjusting for year of birth, gender, smoking, and caffeine intake.	Caffeine	207-215	clusterin	Homo sapiens	18-21
21208171-7	2010	An accurate prediction for the CYP1A2-dependent omeprazole-caffeine interaction was also made, demonstrating that the methods are useful for the evaluation of DDIs from induction involving mechanisms other than PXR activation.	Caffeine	59-67	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-37
20863723-1	2010	We describe a new approach to stabilize nonsense mRNA, based on the inhibition of the NMD mechanism, by combining cycloheximide-mediated inhibition of translation, and caffeine-mediated inhibition of UPF1 phosphorylation.	Caffeine	168-176	UPF1 RNA helicase and ATPase	Homo sapiens	200-204
20920578-7	2010	The RyR antagonist ruthenium red inhibited xanthine oxidase-induced potentiation, while the RyR agonist caffeine elevated diaphragm twitch and low-frequency tension in a non-additive manner by 55% when introduced simultaneously with ROS challenge.	Caffeine	104-112	ryanodine receptor 2	Rattus norvegicus	92-95
21112285-0	2010	The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.	Caffeine	60-68	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	32-37
21112285-3	2010	We recently reported that caffeine activates mouse TRPA1 (mTRPA1) but suppresses human TRPA1 (hTRPA1).	Caffeine	26-34	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	51-56
21112285-3	2010	We recently reported that caffeine activates mouse TRPA1 (mTRPA1) but suppresses human TRPA1 (hTRPA1).	Caffeine	26-34	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	58-64
21112285-3	2010	We recently reported that caffeine activates mouse TRPA1 (mTRPA1) but suppresses human TRPA1 (hTRPA1).	Caffeine	26-34	transient receptor potential cation channel subfamily A member 1	Homo sapiens	59-64
21112285-3	2010	We recently reported that caffeine activates mouse TRPA1 (mTRPA1) but suppresses human TRPA1 (hTRPA1).	Caffeine	26-34	transient receptor potential cation channel subfamily A member 1	Homo sapiens	94-100
21112285-6	2010	In a mutagenesis study of this region, we subsequently observed that introduction of a Met268Pro point mutation into mTRPA1 changed the effect of caffeine from activation to suppression.	Caffeine	146-154	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	117-123
21112285-7	2010	Because the region including Met-268 is different from other reported ligand-binding sites and from the EF-hand motif, these results suggest that the caffeine response is mediated by a unique mechanism, and confirm the importance of the distal N-terminal region for regulation of TRPA1 channel activity.	Caffeine	150-158	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	280-285
21208171-7	2010	An accurate prediction for the CYP1A2-dependent omeprazole-caffeine interaction was also made, demonstrating that the methods are useful for the evaluation of DDIs from induction involving mechanisms other than PXR activation.	Caffeine	59-67	nuclear receptor subfamily 1 group I member 2	Homo sapiens	211-214
21918647-1	2010	The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine.	Caffeine	251-259	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-53
20858894-7	2010	This elevated SR Ca(2+) pool in the tric-a(-/-) muscle could be released by caffeine, whereas the elemental Ca(2+) release events, e.g. osmotic stress-induced Ca(2+) spark activities, were significantly reduced likely reflecting compromised counter-ion movement across the SR. Ex vivo physiological test identified the appearance of "alternan" behavior with isolated tric-a(-/-) skeletal muscle, i.e. transient and drastic increase in contractile force appeared within the decreasing force profile during repetitive fatigue stimulation.	Caffeine	76-84	transmembrane protein 38A	Homo sapiens	36-42
20924570-3	2010	Enzyme activities of CYP1A2 and CYP3A4 were determined as metabolic ratios of caffeine (CMR = (AFMU + 1MU + 1MX)/17DMU) and quinidine (QMR = 3-hydroxy-quinidine/quinidine) respectively before and 34 h after insertion of the suppository.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
20924570-3	2010	Enzyme activities of CYP1A2 and CYP3A4 were determined as metabolic ratios of caffeine (CMR = (AFMU + 1MU + 1MX)/17DMU) and quinidine (QMR = 3-hydroxy-quinidine/quinidine) respectively before and 34 h after insertion of the suppository.	Caffeine	78-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38
20884878-13	2010	As a result, heart muscle isolated from bag3(-/-) mice exhibited myofibrillar degeneration and lost contractile activity after caffeine contraction.	Caffeine	127-135	BCL2-associated athanogene 3	Mus musculus	40-44
21918647-1	2010	The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine.	Caffeine	251-259	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-43
21918647-1	2010	The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine.	Caffeine	251-259	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	75-79
20600030-11	2010	CONCLUSIONS: UGT1A genes are induced in vitro and in vivo by coffee, independent of caffeine content, cafestol, or kahweol.	Caffeine	84-92	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-18
20652277-5	2010	Inducibility of RyR- and IP3-R-mediated Ca(2+) transients in individual cells was tested by exposure to caffeine and ATP, respectively; expression of cardiac and non-cardiac lineage markers was assessed.	Caffeine	104-112	ryanodine receptor 1, skeletal muscle	Mus musculus	16-19
20652277-5	2010	Inducibility of RyR- and IP3-R-mediated Ca(2+) transients in individual cells was tested by exposure to caffeine and ATP, respectively; expression of cardiac and non-cardiac lineage markers was assessed.	Caffeine	104-112	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	25-30
20861183-7	2010	Human tumor cells also show AR of similar magnitude that is compromised by caffeine, an inhibitor of DNA damage signaling acting by inhibiting ATM, ATR, and DNA-PKcs.	Caffeine	75-83	ATM serine/threonine kinase	Homo sapiens	143-146
20861183-7	2010	Human tumor cells also show AR of similar magnitude that is compromised by caffeine, an inhibitor of DNA damage signaling acting by inhibiting ATM, ATR, and DNA-PKcs.	Caffeine	75-83	ATR serine/threonine kinase	Homo sapiens	148-151
20861183-7	2010	Human tumor cells also show AR of similar magnitude that is compromised by caffeine, an inhibitor of DNA damage signaling acting by inhibiting ATM, ATR, and DNA-PKcs.	Caffeine	75-83	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	157-165
20853468-1	2010	Caffeine has been extensively used as a probe to measure CYP1A2 activity in humans with caffeine clearance or the paraxanthine (major metabolite of caffeine) to caffeine concentration ratio being regarded as the preferred metric.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
20692237-4	2010	Acute injection of caffeine (10 and 20mg/kg s.c.) decreased the threshold for stimulation-bound movements in both age groups while it increased the thresholds for spike-and-wave ADs and clonic seizures accompanying them at P25.	Caffeine	19-27	lipocalin 2	Rattus norvegicus	223-226
20692237-7	2010	However, acute caffeine exerted a prolongation of ADs at P25 which effect was alleviated after both developmental periods of treatment.	Caffeine	15-23	lipocalin 2	Rattus norvegicus	57-60
20723593-2	2010	AIM OF THE STUDY: This study was designed to investigate the effects of LDW on the activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO) in healthy subjects, using caffeine as a probe drug.	Caffeine	195-203	N-acetyltransferase 2	Homo sapiens	136-140
20723593-6	2010	RESULTS: Compared to placebo, LDW significantly induced the CYP1A2 activity, as determined by an increase in the ratio of (AFMU+1U+1X)/17U and the formation of 17X and 1X after taking caffeine.	Caffeine	184-192	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
20638472-2	2010	Caffeine has antioxidant properties and has been demonstrated to reduce Abeta levels in transgenic mouse models of familial AD.	Caffeine	0-8	amyloid beta (A4) precursor protein	Mus musculus	72-77
20638472-7	2010	Caffeine, administered at 0.5 and 30mg/day in the drinking water, reduced the cholesterol-induced increase in Abeta, phosphorylated tau, and oxidative stress levels and reversed the cholesterol-induced decrease in A(1)R levels.	Caffeine	0-8	amyloid beta (A4) precursor protein	Mus musculus	110-115
21034594-11	2010	CONCLUSIONS: We found that stimulatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS.	Caffeine	68-76	cholinergic receptor muscarinic 3	Homo sapiens	118-124
20413215-3	2010	However, GA-induced p53 activation could be partially reversed by caffeine, a PI3k inhibitor.	Caffeine	66-74	tumor protein p53	Homo sapiens	20-23
20413215-9	2010	Furthermore, we found the dephosphorylation of Cdk1 at Thr161 induced by GA was abrogated, followed by a remarkable disruption of G2/M arrest when the cells were pre-incubated with caffeine.	Caffeine	181-189	cyclin dependent kinase 1	Homo sapiens	47-51
20180783-13	2010	Caffeine and theophylline also reduced contraction-stimulated glucose uptake, which occurs independently of PI3-kinase/PKB, and we hypothesize that caffeine and theophylline also inhibit glucose uptake in skeletal muscles via an additional and hitherto unknown molecule involved in GLUT4 translocation.	Caffeine	0-8	solute carrier family 2 member 4	Rattus norvegicus	282-287
20734998-9	2010	To address the involvement of ataxia telangiectasia mutated/ATM-Rad3-related (ATM/ATR) kinase in the signaling of ACR-induced G(0)/G(1) arrest, caffeine was used to block the ATM/ATR pathway in U-1240 MG cells.	Caffeine	144-152	ATM serine/threonine kinase	Homo sapiens	78-85
20180783-6	2010	Furthermore, insulin-stimulated PKB Ser(473) and Thr(308) and GSK-3beta Ser(9) phosphorylation were blocked by caffeine and theophylline.	Caffeine	111-119	glycogen synthase kinase 3 beta	Rattus norvegicus	62-71
20577678-8	2010	Caffeine was found to increase adenosine deaminase activity.	Caffeine	0-8	adenosine deaminase	Homo sapiens	31-50
20180783-13	2010	Caffeine and theophylline also reduced contraction-stimulated glucose uptake, which occurs independently of PI3-kinase/PKB, and we hypothesize that caffeine and theophylline also inhibit glucose uptake in skeletal muscles via an additional and hitherto unknown molecule involved in GLUT4 translocation.	Caffeine	148-156	solute carrier family 2 member 4	Rattus norvegicus	282-287
20735427-11	2010	AGE-RAGE signalling in mast cells involves Pertussis toxin-sensitive G(i)-proteins and intracellular Ca(2+) increases as pretreatment with Pertussis toxin, caffeine, 2-APB and BAPTA-AM inhibited AGE-induced exocytosis.	Caffeine	156-164	long intergenic non-protein coding RNA 914	Homo sapiens	4-8
20812900-8	2010	Besides, some natural products, such as epigallocatechin gallate (EGCG), caffeine, curcumin and resveratrol, have been found to inhibit mTOR as well.	Caffeine	73-81	mechanistic target of rapamycin kinase	Homo sapiens	136-140
20716633-4	2010	CYP1A2, CYP2D6, CYP2C9, and CYP3A4 enzyme activities were measured by the metabolism of caffeine, dextromethorphan, losartan, and buspirone, respectively.	Caffeine	88-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34
20716633-4	2010	CYP1A2, CYP2D6, CYP2C9, and CYP3A4 enzyme activities were measured by the metabolism of caffeine, dextromethorphan, losartan, and buspirone, respectively.	Caffeine	88-96	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	matrix metallopeptidase 2	Homo sapiens	17-43
20615571-1	2010	"Intraperitoneal application of caffeine prevents D-galactosamine induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat" [JHEPAT 50 (2009) 1053-1055].	Caffeine	32-40	cellular communication network factor 2	Rattus norvegicus	96-127
20615571-1	2010	"Intraperitoneal application of caffeine prevents D-galactosamine induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat" [JHEPAT 50 (2009) 1053-1055].	Caffeine	32-40	cellular communication network factor 2	Rattus norvegicus	129-133
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	180-183
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	matrix metallopeptidase 2	Homo sapiens	45-50
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-194
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	matrix metallopeptidase 9	Homo sapiens	56-61
20432471-1	2010	Caffeine attenuated invasion of human leukemia U937 cells with characteristic of decreased protein expression and mRNA levels of matrix metalloproteinase-2 (MMP-2) and MMP-9.	Caffeine	0-8	matrix metallopeptidase 2	Homo sapiens	129-155
20432471-1	2010	Caffeine attenuated invasion of human leukemia U937 cells with characteristic of decreased protein expression and mRNA levels of matrix metalloproteinase-2 (MMP-2) and MMP-9.	Caffeine	0-8	matrix metallopeptidase 2	Homo sapiens	157-162
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	144-147
20432471-1	2010	Caffeine attenuated invasion of human leukemia U937 cells with characteristic of decreased protein expression and mRNA levels of matrix metalloproteinase-2 (MMP-2) and MMP-9.	Caffeine	0-8	matrix metallopeptidase 9	Homo sapiens	168-173
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-153
20432471-2	2010	Down-regulation of MMP-2 and MMP-9 in U937 cells was abrogated by abolishment of caffeine-elicited increase in intracellular Ca(2+) concentration and ROS generation.	Caffeine	81-89	matrix metallopeptidase 2	Homo sapiens	19-24
20432471-2	2010	Down-regulation of MMP-2 and MMP-9 in U937 cells was abrogated by abolishment of caffeine-elicited increase in intracellular Ca(2+) concentration and ROS generation.	Caffeine	81-89	matrix metallopeptidase 9	Homo sapiens	29-34
20557899-4	2010	Caffeine was detected in all August 2006 samples and in 33% of February 2007 samples at concentrations up to 88ngL(-1).	Caffeine	0-8	leucine rich repeat containing 4C	Homo sapiens	111-117
20432471-3	2010	Pretreatment with BAPTA-AM (Ca(2+) chelator) and N-acetylcysteine (ROS scavenger) abolished caffeine-induced ERK inactivation and p38 MPAK activation.	Caffeine	92-100	mitogen-activated protein kinase 1	Homo sapiens	109-112
20432471-3	2010	Pretreatment with BAPTA-AM (Ca(2+) chelator) and N-acetylcysteine (ROS scavenger) abolished caffeine-induced ERK inactivation and p38 MPAK activation.	Caffeine	92-100	mitogen-activated protein kinase 14	Homo sapiens	130-133
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	dual specificity phosphatase 1	Homo sapiens	36-54
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	dual specificity phosphatase 1	Homo sapiens	56-61
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	91-123
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	125-130
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	mitogen-activated protein kinase 14	Homo sapiens	189-192
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	mitogen-activated protein kinase 1	Homo sapiens	36-40
20432471-4	2010	Moreover, caffeine treatment led to MAPK phosphatase-1 (MKP-1) down-regulation and protein phosphatase 2A catalytic subunit (PP2Ac) up-regulation, which were involved in cross-talk between p38 MAPK and ERK.	Caffeine	10-18	mitogen-activated protein kinase 1	Homo sapiens	202-205
20432471-5	2010	Transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) restored MMP-2 and MMP-9 protein expression in caffeine-treated cells.	Caffeine	141-149	mitogen-activated protein kinase kinase 1	Homo sapiens	38-42
20432471-5	2010	Transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) restored MMP-2 and MMP-9 protein expression in caffeine-treated cells.	Caffeine	141-149	mitogen-activated protein kinase 14	Homo sapiens	74-77
20432471-5	2010	Transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) restored MMP-2 and MMP-9 protein expression in caffeine-treated cells.	Caffeine	141-149	matrix metallopeptidase 2	Homo sapiens	103-108
20432471-5	2010	Transfection of constitutively active MEK1 or pretreatment with SB202190 (p38 MAPK inhibitor) restored MMP-2 and MMP-9 protein expression in caffeine-treated cells.	Caffeine	141-149	matrix metallopeptidase 9	Homo sapiens	113-118
20432471-6	2010	Caffeine treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated c-Jun phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	29-32
20432471-6	2010	Caffeine treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated c-Jun phosphorylation.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
20432471-6	2010	Caffeine treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated c-Jun phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	75-78
20432471-6	2010	Caffeine treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated c-Jun phosphorylation.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	79-83
20432471-6	2010	Caffeine treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38 MAPK-mediated c-Jun phosphorylation.	Caffeine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	matrix metallopeptidase 2	Homo sapiens	39-44
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	matrix metallopeptidase 9	Homo sapiens	45-50
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	mitogen-activated protein kinase 1	Homo sapiens	148-151
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	mitogen-activated protein kinase 14	Homo sapiens	184-187
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	Caffeine	70-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	193-198
20221667-9	2010	Kupffer cells isolated from ethanol-fed mice produced high amounts of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha), whereas Kupffer cells from caffeine treatment mice produced less ROS and TNF-alpha.	Caffeine	172-180	tumor necrosis factor	Mus musculus	218-227
20532872-7	2010	Polymorphism in the metabolic enzyme cytochrome P-450 is associated with risk of myocardial infarction in caffeine users.	Caffeine	106-114	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-53
20520601-0	2010	Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.	Caffeine	54-62	adenosine A2a receptor	Homo sapiens	68-75
20520601-0	2010	Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.	Caffeine	54-62	adenosine A1 receptor	Homo sapiens	80-86
20520601-2	2010	An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported for individuals who habitually consume little caffeine.	Caffeine	73-81	adenosine A2a receptor	Homo sapiens	44-51
20520601-2	2010	An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported for individuals who habitually consume little caffeine.	Caffeine	162-170	adenosine A2a receptor	Homo sapiens	44-51
20493822-0	2010	Caffeine modulates CREB-dependent gene expression in developing cortical neurons.	Caffeine	0-8	cAMP responsive element binding protein 1	Homo sapiens	19-23
21416940-4	2010	The urinary caffeine metabolites ratios are commonly used in the assessment of activities of drug metabolizing enzymes, mainly including CYP1A2, CYP2A6, N-acetyltransferase and xanthine oxidase.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	137-143
21416940-4	2010	The urinary caffeine metabolites ratios are commonly used in the assessment of activities of drug metabolizing enzymes, mainly including CYP1A2, CYP2A6, N-acetyltransferase and xanthine oxidase.	Caffeine	12-20	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	145-151
20676041-10	2010	Furthermore, the E189D mutation enhances the basal channel activity of RyR2 and its sensitivity to activation by caffeine.	Caffeine	113-121	ryanodine receptor 2, cardiac	Mus musculus	71-75
20576036-3	2010	These aversive effects are mediated by the dopamine D(2) receptor, as knockout mice showed conditioned place preferences in response to doses of caffeine that C57Bl/6 mice found aversive.	Caffeine	145-153	dopamine receptor D2	Mus musculus	43-65
20589924-0	2010	Caffeine and stress alter salivary alpha-amylase activity in young men.	Caffeine	0-8	amylase alpha 1A	Homo sapiens	26-48
20589924-5	2010	Changes in sAA activity across the session were dependent on the amount of caffeine consumed.	Caffeine	75-83	amylase alpha 1A	Homo sapiens	11-14
20589924-7	2010	Separate repeated-measures ANOVAs conducted for each drug treatment group revealed that sAA activity increased in response to stress and caffeine (i.e., 200 and 400 mg groups) but not to stress alone (i.e., placebo group).	Caffeine	137-145	amylase alpha 1A	Homo sapiens	88-91
20589924-8	2010	CONCLUSIONS: Findings provide evidence for acute sAA changes in response to caffeine and stress in habitual caffeine users.	Caffeine	76-84	amylase alpha 1A	Homo sapiens	49-52
20589924-8	2010	CONCLUSIONS: Findings provide evidence for acute sAA changes in response to caffeine and stress in habitual caffeine users.	Caffeine	108-116	amylase alpha 1A	Homo sapiens	49-52
20304699-6	2010	Marginally significant interactions were observed between caffeine intake and the ESR1 polymorphism rs3798577 (p=0.07) and ESR2 polymorphism rs1255998 (p=0.07).	Caffeine	58-66	estrogen receptor 1	Homo sapiens	82-86
20304699-7	2010	The observed increased risk of PD among female but not male carriers of the rs762551 polymorphism of CYP1A2 and the interactions of caffeine with ESR1 rs3798577 and ESR2 rs1255998 may provide clues to explain the relationship between gender, caffeine intake, estrogen status and risk of PD and need to be replicated.	Caffeine	132-140	estrogen receptor 1	Homo sapiens	146-150
20641098-9	2010	Multiplicative interaction effects were observed between maternal caffeine and infant CYP1A2*1F fast oxidizer status (p(interaction) = 0.03).	Caffeine	66-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	86-92
20232318-3	2010	NECA increased phosphorylation of Cx43 which was blocked by caffeine, a non-selective adenosine receptor antagonist.	Caffeine	60-68	gap junction protein, alpha 1	Mus musculus	34-38
20232318-7	2010	Moreover, NECA-treated cells demonstrated phosphorylation of Src, which was blocked by caffeine.	Caffeine	87-95	Rous sarcoma oncogene	Mus musculus	61-64
20232318-9	2010	In a further study, phosphorylations of integrin beta1, focal adhesion kinase (FAK), and paxillin by NECA were restrained by caffeine as well as the Src blocker, PP2.	Caffeine	125-133	integrin beta 1 (fibronectin receptor beta)	Mus musculus	40-54
20232318-9	2010	In a further study, phosphorylations of integrin beta1, focal adhesion kinase (FAK), and paxillin by NECA were restrained by caffeine as well as the Src blocker, PP2.	Caffeine	125-133	PTK2 protein tyrosine kinase 2	Mus musculus	56-77
20232318-9	2010	In a further study, phosphorylations of integrin beta1, focal adhesion kinase (FAK), and paxillin by NECA were restrained by caffeine as well as the Src blocker, PP2.	Caffeine	125-133	PTK2 protein tyrosine kinase 2	Mus musculus	79-82
20232318-10	2010	Finally, we identified that NECA-stimulated cell migration and expressions of cell-cycle regulatory proteins [cyclin D1, cyclin-dependent kinase (CDK) 4, cyclin E, and CDK2]; these increases were inhibited by caffeine, or PP2.	Caffeine	209-217	cyclin D1	Mus musculus	110-119
20232318-10	2010	Finally, we identified that NECA-stimulated cell migration and expressions of cell-cycle regulatory proteins [cyclin D1, cyclin-dependent kinase (CDK) 4, cyclin E, and CDK2]; these increases were inhibited by caffeine, or PP2.	Caffeine	209-217	neuropeptide Y receptor Y6	Mus musculus	222-225
20302875-7	2010	Consistently, CSQ(K206N)-expressing myocytes exhibited an impaired response to caffeine administration, suggesting a lower Ca(2+) load of the sarcoplasmic reticulum (SR).	Caffeine	79-87	calsequestrin 1	Mus musculus	14-17
20493822-2	2010	Here we investigated the ability of caffeine to stimulate CREB-dependent gene transcription in primary cultures of developing mouse cortical neurons.	Caffeine	36-44	cAMP responsive element binding protein 1	Mus musculus	58-62
20493822-3	2010	Using the CREB-dependent reporter gene CRE-luciferase we show that stimulation of CREB activity by caffeine exhibits a bell-shaped dose-response curve.	Caffeine	99-107	cAMP responsive element binding protein 1	Homo sapiens	10-14
20493822-3	2010	Using the CREB-dependent reporter gene CRE-luciferase we show that stimulation of CREB activity by caffeine exhibits a bell-shaped dose-response curve.	Caffeine	99-107	cAMP responsive element binding protein 1	Homo sapiens	82-86
20493822-5	2010	In our immature neuronal cultures, 10mM caffeine was more effective at stimulating CREB activity than depolarization with high extracellular KCl (50mM).	Caffeine	40-48	cAMP responsive element binding protein 1	Homo sapiens	83-87
20493822-6	2010	Quantitative real-time PCR analysis demonstrated that transcripts derived from endogenous CREB target genes, such as the gene encoding brain-derived neurotrophic factor BDNF, are increased following caffeine treatment.	Caffeine	199-207	cAMP responsive element binding protein 1	Homo sapiens	90-94
20493822-6	2010	Quantitative real-time PCR analysis demonstrated that transcripts derived from endogenous CREB target genes, such as the gene encoding brain-derived neurotrophic factor BDNF, are increased following caffeine treatment.	Caffeine	199-207	brain derived neurotrophic factor	Homo sapiens	135-168
20493822-6	2010	Quantitative real-time PCR analysis demonstrated that transcripts derived from endogenous CREB target genes, such as the gene encoding brain-derived neurotrophic factor BDNF, are increased following caffeine treatment.	Caffeine	199-207	brain derived neurotrophic factor	Homo sapiens	169-173
20493822-7	2010	The dose-response curves of CREB target genes to caffeine exhibited gene-specificity, highlighting the importance of promoter structure in shaping genomic responses to Ca(2+) signaling.	Caffeine	49-57	cAMP responsive element binding protein 1	Homo sapiens	28-32
20493822-8	2010	In the presence of a weak depolarizing stimulus (10mM KCl), concentrations of caffeine relevant for premature infants undergoing caffeine treatment increased CRE-luciferase activity and Bdnf transcript levels.	Caffeine	78-86	brain derived neurotrophic factor	Homo sapiens	186-190
20493822-8	2010	In the presence of a weak depolarizing stimulus (10mM KCl), concentrations of caffeine relevant for premature infants undergoing caffeine treatment increased CRE-luciferase activity and Bdnf transcript levels.	Caffeine	129-137	brain derived neurotrophic factor	Homo sapiens	186-190
20493822-9	2010	The ability of caffeine to enhance activity-dependent Bdnf expression may contribute to the neurological benefit observed in infants receiving caffeine treatment.	Caffeine	15-23	brain derived neurotrophic factor	Homo sapiens	54-58
20493822-9	2010	The ability of caffeine to enhance activity-dependent Bdnf expression may contribute to the neurological benefit observed in infants receiving caffeine treatment.	Caffeine	143-151	brain derived neurotrophic factor	Homo sapiens	54-58
20388713-4	2010	In response to rapamycin, caffeine, glucose starvation and oxidative stress provoked by H(2)O(2), mtl1 presents a significant loss of viability as well as a deficiency in the transcriptional response mediated by Msn2/Msn4.	Caffeine	26-34	Mtl1p	Saccharomyces cerevisiae S288C	98-102
20484172-8	2010	Urinary caffeine metabolite ratios were used as the indicators of the activities of CYP1A2, CYP2A6, NAT2, and XO.	Caffeine	8-16	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	84-90
20304819-5	2010	Such IP(3)R-gated Ca(2+) releases were amplified by Ca(2+)-induced Ca(2+) release (CICR) via RyRs since they were also reduced by compounds that block the RyRs (tetracaine) or deplete the Ca(2+) pools they gate (caffeine, ryanodine).	Caffeine	212-220	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-11
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	Caffeine	66-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-47
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	Caffeine	66-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
20384627-10	2010	At 15 Gy, expression of CDC2-Tyr15-P in the Caff + IR group (26.0 +/- 8.9%) was significantly lower than in the IR alone group (68.4 +/- 10.6%), expression of cyclinB1 and proportion of TUNEL-positive cells in the Caff + IR group (30.4 +/- 8.7% and 59.2 +/- 9.5%, respectively) was significantly higher than in the IR alone group (7.0 +/- 3.7% and 24.2 +/- 7.2%, respectively), expression of caspase-3 was consistent with the TUNEL staining results.	Caffeine	44-48	cyclin-dependent kinase 1	Mus musculus	24-28
20384627-10	2010	At 15 Gy, expression of CDC2-Tyr15-P in the Caff + IR group (26.0 +/- 8.9%) was significantly lower than in the IR alone group (68.4 +/- 10.6%), expression of cyclinB1 and proportion of TUNEL-positive cells in the Caff + IR group (30.4 +/- 8.7% and 59.2 +/- 9.5%, respectively) was significantly higher than in the IR alone group (7.0 +/- 3.7% and 24.2 +/- 7.2%, respectively), expression of caspase-3 was consistent with the TUNEL staining results.	Caffeine	44-48	cyclin B1	Mus musculus	159-167
20384627-10	2010	At 15 Gy, expression of CDC2-Tyr15-P in the Caff + IR group (26.0 +/- 8.9%) was significantly lower than in the IR alone group (68.4 +/- 10.6%), expression of cyclinB1 and proportion of TUNEL-positive cells in the Caff + IR group (30.4 +/- 8.7% and 59.2 +/- 9.5%, respectively) was significantly higher than in the IR alone group (7.0 +/- 3.7% and 24.2 +/- 7.2%, respectively), expression of caspase-3 was consistent with the TUNEL staining results.	Caffeine	44-48	caspase 3	Mus musculus	392-401
20384627-10	2010	At 15 Gy, expression of CDC2-Tyr15-P in the Caff + IR group (26.0 +/- 8.9%) was significantly lower than in the IR alone group (68.4 +/- 10.6%), expression of cyclinB1 and proportion of TUNEL-positive cells in the Caff + IR group (30.4 +/- 8.7% and 59.2 +/- 9.5%, respectively) was significantly higher than in the IR alone group (7.0 +/- 3.7% and 24.2 +/- 7.2%, respectively), expression of caspase-3 was consistent with the TUNEL staining results.	Caffeine	214-218	cyclin-dependent kinase 1	Mus musculus	24-28
21577056-6	2010	We also showed that co-treatment with caffeine induces a slight increase in the susceptibility to genotoxic agents in kin3 cells and abolishes KIN3 gene expression in wild-type strain, suggesting that Kin3p can play a role in Tel1/Mec1-dependent pathway activation induced after genotoxic stress.	Caffeine	38-46	serine/threonine protein kinase KIN3	Saccharomyces cerevisiae S288C	118-122
21577056-6	2010	We also showed that co-treatment with caffeine induces a slight increase in the susceptibility to genotoxic agents in kin3 cells and abolishes KIN3 gene expression in wild-type strain, suggesting that Kin3p can play a role in Tel1/Mec1-dependent pathway activation induced after genotoxic stress.	Caffeine	38-46	serine/threonine protein kinase KIN3	Saccharomyces cerevisiae S288C	143-147
20484172-8	2010	Urinary caffeine metabolite ratios were used as the indicators of the activities of CYP1A2, CYP2A6, NAT2, and XO.	Caffeine	8-16	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	92-98
20138887-5	2010	Stim1-KD but not Orai1-KD significantly decreased diastolic Ca(2+) levels and caffeine-releasable Ca(2+) from the sarcoplasmic reticulum (SR).	Caffeine	78-86	stromal interaction molecule 1	Rattus norvegicus	0-5
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	vascular endothelial growth factor A	Homo sapiens	145-149
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	tumor necrosis factor	Homo sapiens	170-179
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	interleukin 1 alpha	Homo sapiens	181-184
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	growth hormone releasing hormone	Homo sapiens	190-194
20116384-7	2010	With the clues of upregulated mRNA expression of calcium handling proteins, ryanodine receptor 2, sodium calcium exchanger and sarcoplasmic/endoplasmic reticulum calcium ATPase, in the transduced HIF-1 alpha ESCs, further study indicated that the maximum upstroke and decay velocity was significantly increased in both non-caffeine and caffeine-induced calcium transient in ESCs-derived cardiomyocytes.	Caffeine	323-331	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-207
20155256-4	2010	In 100 of them, CYP2A6 and XO activities were determined by the urinary 17U/17X and 1U/(1U + 1X) ratios, respectively, after oral administration of 100 mg caffeine as a probe.	Caffeine	155-163	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	16-22
20116384-7	2010	With the clues of upregulated mRNA expression of calcium handling proteins, ryanodine receptor 2, sodium calcium exchanger and sarcoplasmic/endoplasmic reticulum calcium ATPase, in the transduced HIF-1 alpha ESCs, further study indicated that the maximum upstroke and decay velocity was significantly increased in both non-caffeine and caffeine-induced calcium transient in ESCs-derived cardiomyocytes.	Caffeine	336-344	hypoxia inducible factor 1, alpha subunit	Mus musculus	196-207
19485922-8	2010	CGRP also increases the amplitude of caffeine-induced Ca(2+) release (400 %); suggesting increased SR Ca(2+) content underlies stimulation of VGCR.	Caffeine	37-45	calcitonin related polypeptide alpha	Homo sapiens	0-4
24149694-0	2010	Caffeine attenuates acute growth hormone response to a single bout of resistance exercise.	Caffeine	0-8	growth hormone 1	Homo sapiens	26-40
24149694-8	2010	After ingesting caffeine, the concentrations of free fatty acid (pre- exe, P0, P15, P30) in CAF were significantly higher than CON (p &lt; 0.05).	Caffeine	16-24	cyclin dependent kinase inhibitor 2B	Homo sapiens	79-82
24149694-8	2010	After ingesting caffeine, the concentrations of free fatty acid (pre- exe, P0, P15, P30) in CAF were significantly higher than CON (p &lt; 0.05).	Caffeine	16-24	centromere protein V	Homo sapiens	84-87
24149694-8	2010	After ingesting caffeine, the concentrations of free fatty acid (pre- exe, P0, P15, P30) in CAF were significantly higher than CON (p &lt; 0.05).	Caffeine	92-95	cyclin dependent kinase inhibitor 2B	Homo sapiens	79-82
24149694-8	2010	After ingesting caffeine, the concentrations of free fatty acid (pre- exe, P0, P15, P30) in CAF were significantly higher than CON (p &lt; 0.05).	Caffeine	92-95	centromere protein V	Homo sapiens	84-87
24149694-9	2010	Additionally, the responses of GH (P0, P15, P30) in CAF were significantly lower than CON (p &lt; 0.05), whereas the concentrations of insulin, testosterone and cortisol were not different between CAF and CON (p &lt; 0.05) after RE.	Caffeine	52-55	cyclin dependent kinase inhibitor 2B	Homo sapiens	39-42
24149694-9	2010	Additionally, the responses of GH (P0, P15, P30) in CAF were significantly lower than CON (p &lt; 0.05), whereas the concentrations of insulin, testosterone and cortisol were not different between CAF and CON (p &lt; 0.05) after RE.	Caffeine	52-55	centromere protein V	Homo sapiens	44-47
20498834-7	2010	In contrast to DNA replication stress, in response to the cell wall integrity pathway activator caffeine, PUF5 and POP2 acted in the same genetic pathway, indicating that functions of Puf5 in the caffeine response are mediated by Pop2-dependent gene repression.	Caffeine	96-104	Mpt5p	Saccharomyces cerevisiae S288C	184-188
20498834-7	2010	In contrast to DNA replication stress, in response to the cell wall integrity pathway activator caffeine, PUF5 and POP2 acted in the same genetic pathway, indicating that functions of Puf5 in the caffeine response are mediated by Pop2-dependent gene repression.	Caffeine	96-104	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	230-234
20498834-7	2010	In contrast to DNA replication stress, in response to the cell wall integrity pathway activator caffeine, PUF5 and POP2 acted in the same genetic pathway, indicating that functions of Puf5 in the caffeine response are mediated by Pop2-dependent gene repression.	Caffeine	196-204	Mpt5p	Saccharomyces cerevisiae S288C	106-110
20498834-7	2010	In contrast to DNA replication stress, in response to the cell wall integrity pathway activator caffeine, PUF5 and POP2 acted in the same genetic pathway, indicating that functions of Puf5 in the caffeine response are mediated by Pop2-dependent gene repression.	Caffeine	196-204	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	115-119
20498834-7	2010	In contrast to DNA replication stress, in response to the cell wall integrity pathway activator caffeine, PUF5 and POP2 acted in the same genetic pathway, indicating that functions of Puf5 in the caffeine response are mediated by Pop2-dependent gene repression.	Caffeine	196-204	Mpt5p	Saccharomyces cerevisiae S288C	184-188
19908252-2	2010	In the present work pregnant rats were treated daily with 1 g/L of caffeine in their drinking water during pregnancy and/or lactation and the effect on adenosine A(1) receptor in brains from both lactating mothers and 15 days-old neonates was assayed using radioligand binding and real time PCR assays.	Caffeine	67-75	adenosine A1 receptor	Rattus norvegicus	152-175
20123862-2	2010	The slight sensitivity of XP-V cells to UV is dramatically enhanced by low concentrations of caffeine.	Caffeine	93-101	DNA polymerase eta	Homo sapiens	26-30
20123862-6	2010	Addition of a low concentration of caffeine post-irradiation, although inefficient to restore S-phase progression, significantly decreases Chk1 activation and abrogates DNA synthesis in XP-V cells.	Caffeine	35-43	checkpoint kinase 1	Homo sapiens	139-143
20123862-6	2010	Addition of a low concentration of caffeine post-irradiation, although inefficient to restore S-phase progression, significantly decreases Chk1 activation and abrogates DNA synthesis in XP-V cells.	Caffeine	35-43	DNA polymerase eta	Homo sapiens	186-190
19908252-3	2010	Mothers receiving caffeine during gestational period developed motor activation in gestational days 8-10 which was associated with a significant decrease of total adenosine A(1) receptor number (84%).	Caffeine	18-26	adenosine A1 receptor	Rattus norvegicus	163-186
19908252-4	2010	A similar decrease was detected in mothers treated with caffeine during lactation (76%) and throughout gestation and lactation (73%); this was accompanied by a significant decrease in mRNA level coding adenosine A(1) receptor (28%).	Caffeine	56-64	adenosine A1 receptor	Rattus norvegicus	202-225
20045733-7	2010	The purified rRBP elicited bitterness reduction against quinine and caffeine, although it largely lost its riboflavin-binding ability.	Caffeine	68-76	retinol binding protein 4	Rattus norvegicus	13-17
20029831-0	2010	Role of dopamine D(1) receptors in caffeine-mediated ERK phosphorylation in the rat brain.	Caffeine	35-43	Eph receptor B1	Rattus norvegicus	53-56
20029831-1	2010	The aim of this research was to study the role of dopamine D(1) receptors in caffeine elicited ERK phosphorylation in the prefrontal and other cortical (cingulate and motor) and subcortical (shell and core of the nucleus accumbens) regions.	Caffeine	77-85	Eph receptor B1	Rattus norvegicus	95-98
19908252-5	2010	In male neonates, adenosine A(1) receptor was also decreased after chronic caffeine exposure during gestation (80%), lactation (76%) and gestation plus lactation (80%).	Caffeine	75-83	adenosine A1 receptor	Rattus norvegicus	18-41
19908252-6	2010	In female neonates, adenosine A(1) receptor tended to decrease in response to caffeine exposure although no significant variations were found.	Caffeine	78-86	adenosine A1 receptor	Rattus norvegicus	20-43
19926639-0	2010	Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice.	Caffeine	23-31	cyclin B1	Mus musculus	117-126
19882200-6	2010	Caffeine potentiated the increase in CD11b and GFAP in the striatum but not in the SNc of MDMA-treated mice.	Caffeine	0-8	integrin alpha M	Mus musculus	37-42
19882200-6	2010	Caffeine potentiated the increase in CD11b and GFAP in the striatum but not in the SNc of MDMA-treated mice.	Caffeine	0-8	glial fibrillary acidic protein	Mus musculus	47-51
20348945-8	2010	In hypoxic VSMCs, RyR activation by caffeine significantly evoked the rise of [Ca(2+)] compared with the control cells, a phenomenon closely associated with the development of vascular hyporeactivity in hemorrhagic shock rats.	Caffeine	36-44	ryanodine receptor 2	Rattus norvegicus	18-21
20348945-10	2010	RyR activation by caffeine and BK(Ca) channel activation by NS1619 attenuated the restoration of vasoreactivity to NE resulting from A(3)AR stimulation by IB-MECA after hemorrhagic shock; this attenuation effect could be antagonized by a selective BK(Ca) channel blocker.	Caffeine	18-26	ryanodine receptor 2	Rattus norvegicus	0-3
20179577-8	2010	Ephedrine diminished aggregation responses to ADP and gamma-thrombin, and this sympathomimetic reduced RANTES exocytosis, basal CD62p expression, and aggregation in platelets exposed to caffeine.	Caffeine	186-194	C-C motif chemokine ligand 5	Homo sapiens	103-109
20179577-8	2010	Ephedrine diminished aggregation responses to ADP and gamma-thrombin, and this sympathomimetic reduced RANTES exocytosis, basal CD62p expression, and aggregation in platelets exposed to caffeine.	Caffeine	186-194	selectin P	Homo sapiens	128-133
19926639-0	2010	Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice.	Caffeine	23-31	transformation related protein 53, pseudogene	Mus musculus	159-162
19926639-3	2010	Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice.	Caffeine	69-77	transformation related protein 53, pseudogene	Mus musculus	50-53
19926639-3	2010	Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice.	Caffeine	69-77	cyclin B1	Mus musculus	124-133
19926639-3	2010	Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice.	Caffeine	69-77	transformation related protein 53, pseudogene	Mus musculus	161-164
19926639-4	2010	p53(-/-) mice, but not p53(+/+) mice, treated with caffeine during exercise exhibited a dramatic decrease in the level of survivin.	Caffeine	51-59	transformation related protein 53, pseudogene	Mus musculus	0-3
19926639-4	2010	p53(-/-) mice, but not p53(+/+) mice, treated with caffeine during exercise exhibited a dramatic decrease in the level of survivin.	Caffeine	51-59	baculoviral IAP repeat-containing 5	Mus musculus	122-130
20087854-4	2010	The striatum is in fact a subcortical area involved in sensorimotor, cognitive, and emotional processes, and recent experimental findings showed that chronic caffeine consumption enhances the sensitivity of striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.	Caffeine	158-166	cannabinoid receptor 1	Homo sapiens	269-272
19883656-8	2010	However, ODF was abolished by adding BAPTA to the internal solution or by depleting sarcoplasmic reticulum (SR) Ca(2+) stores using caffeine and thapsigargin.	Caffeine	132-140	TNF superfamily member 11	Rattus norvegicus	9-12
20473382-8	2010	Based on the results, we concluded that caffeine is useful as an inhibitor of InsP(3)R, and 2-APB at lower concentration is considered a blocker of Ca(2+) entry through SOC channels in the pancreatic acinar cell.	Caffeine	40-48	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	78-86
20384774-1	2010	We have previously reported that caffeine prevented sleep deprivation-induced impairment of long-term potentiation (LTP) of area CA1 as well as hippocampus-dependent learning and memory performance in the radial arm water maze.	Caffeine	33-41	carbonic anhydrase 1	Rattus norvegicus	129-132
20384774-6	2010	Additionally, chronic caffeine treatment prevented the sleep deprivation-associated decreases in the basal levels of the phosphorylated calcium/calmodulin-dependent protein kinase II (P-CaMKII) and brain derived neurotrophic factor (BDNF) as well as in the stimulated levels of P-CaMKII in the DG area.	Caffeine	22-30	brain-derived neurotrophic factor	Rattus norvegicus	198-231
20384774-6	2010	Additionally, chronic caffeine treatment prevented the sleep deprivation-associated decreases in the basal levels of the phosphorylated calcium/calmodulin-dependent protein kinase II (P-CaMKII) and brain derived neurotrophic factor (BDNF) as well as in the stimulated levels of P-CaMKII in the DG area.	Caffeine	22-30	brain-derived neurotrophic factor	Rattus norvegicus	233-237
20384774-7	2010	The results suggest that chronic use of caffeine prevented anomalous changes in the basal levels of P-CaMKII and BDNF associated with sleep deprivation and as a result contributes to the revival of LTP in the DG region.	Caffeine	40-48	brain-derived neurotrophic factor	Rattus norvegicus	113-117
20087854-5	2010	The endocannabinoid system is involved in the psychoactive effects of many compounds, and adenosine A2A receptors (the main receptor target of caffeine) elicit a permissive effect towards CB1 receptors, thus suggesting that A2A-CB1 receptor interaction plays a major role in the generation and maintenance of caffeine reinforcing behavior.	Caffeine	143-151	cannabinoid receptor 1	Homo sapiens	188-191
20087854-5	2010	The endocannabinoid system is involved in the psychoactive effects of many compounds, and adenosine A2A receptors (the main receptor target of caffeine) elicit a permissive effect towards CB1 receptors, thus suggesting that A2A-CB1 receptor interaction plays a major role in the generation and maintenance of caffeine reinforcing behavior.	Caffeine	143-151	immunoglobulin kappa variable 2D-29	Homo sapiens	224-231
20087854-5	2010	The endocannabinoid system is involved in the psychoactive effects of many compounds, and adenosine A2A receptors (the main receptor target of caffeine) elicit a permissive effect towards CB1 receptors, thus suggesting that A2A-CB1 receptor interaction plays a major role in the generation and maintenance of caffeine reinforcing behavior.	Caffeine	309-317	cannabinoid receptor 1	Homo sapiens	188-191
20087854-5	2010	The endocannabinoid system is involved in the psychoactive effects of many compounds, and adenosine A2A receptors (the main receptor target of caffeine) elicit a permissive effect towards CB1 receptors, thus suggesting that A2A-CB1 receptor interaction plays a major role in the generation and maintenance of caffeine reinforcing behavior.	Caffeine	309-317	immunoglobulin kappa variable 2D-29	Homo sapiens	224-231
19941943-7	2010	The permeability coefficient of caffeine in ethanol/water was determined to be 1.56 E-08 cm/s and was improved to 2.27 E-08 cm/s by the addition of NAC.	Caffeine	32-40	X-linked Kx blood group	Homo sapiens	148-151
19032432-6	2010	Following caffeine treatment artificially inducing the AR in miniature pig sperm, Raf was phosphorylated and then MAP kinase kinase (MEK) and extracellular-signal regulated kinase 1 (ERK1) were also phosphorylated in a time-dependent manner.	Caffeine	10-18	mitogen-activated protein kinase 3	Sus scrofa	142-181
19032432-6	2010	Following caffeine treatment artificially inducing the AR in miniature pig sperm, Raf was phosphorylated and then MAP kinase kinase (MEK) and extracellular-signal regulated kinase 1 (ERK1) were also phosphorylated in a time-dependent manner.	Caffeine	10-18	mitogen-activated protein kinase 3	Sus scrofa	183-187
20394312-5	2010	MEASUREMENT AND RESULTS: The results showed that chronic caffeine treatment prevented impairment of hippocampus-dependent learning, shortterm memory and E-LTP of area CA1 in the sleep-deprived rats.	Caffeine	57-65	carbonic anhydrase 1	Rattus norvegicus	167-170
20372009-3	2010	Major metabolism of drugs was ascribed to CYP1A2 for theophylline and caffeine, and CYP1A2 and CYP2D6 for propranolol and mexiletine.	Caffeine	70-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
19962977-2	2010	In the present study, the anti-inflammatory efficacy of a previously identified poly(ADP-ribose) polymerase-1 (PARP-1) inhibiting caffeine metabolite, 1,7-dimethylxanthine, was both in vivo as well as ex vivo evaluated.	Caffeine	130-138	poly(ADP-ribose) polymerase 1	Homo sapiens	111-117
19962977-8	2010	These results suggest that the PARP-1 inhibiting caffeine metabolite 1,7-dimethylxanthine may have therapeutic potential in pulmonary inflammatory diseases such as COPD.	Caffeine	49-57	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
20028385-4	2010	The NKG2DL upregulation was observed only in leukemic cells without apoptosis and the effect was abrogated by pretreatment of cells with caffeine, an inhibitor of ATM/ATR.	Caffeine	137-145	killer cell lectin like receptor C1	Homo sapiens	4-8
20028385-4	2010	The NKG2DL upregulation was observed only in leukemic cells without apoptosis and the effect was abrogated by pretreatment of cells with caffeine, an inhibitor of ATM/ATR.	Caffeine	137-145	ATM serine/threonine kinase	Homo sapiens	163-166
20028385-4	2010	The NKG2DL upregulation was observed only in leukemic cells without apoptosis and the effect was abrogated by pretreatment of cells with caffeine, an inhibitor of ATM/ATR.	Caffeine	137-145	ATR serine/threonine kinase	Homo sapiens	167-170
19926122-9	2010	Caffeine, an inhibitor of the checkpoint kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related), had no effect on the TEGDMA and adriamycin-induced cell cycle arrest.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	49-52
21472222-3	2010	The RyR is also activated by caffeine, a low concentration (&lt;10 microM) of ryanodine or cyclic ADP-ribose.	Caffeine	29-37	ryanodine receptor 1	Homo sapiens	4-7
19032055-5	2010	We observed that caffeine, a RyR agonist, induced a [Ca(2+)](i) response that increased throughout neuronal differentiation.	Caffeine	17-25	ryanodine receptor 1, skeletal muscle	Mus musculus	29-32
20096675-9	2010	Our results suggest that patients who want to use CYP1A2-metabolized drugs such as caffeine and theophylline should be advised of the potential herb-drug interaction, to reduce therapeutic failure or increased toxicity of conventional drug therapy.	Caffeine	83-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
19962977-2	2010	In the present study, the anti-inflammatory efficacy of a previously identified poly(ADP-ribose) polymerase-1 (PARP-1) inhibiting caffeine metabolite, 1,7-dimethylxanthine, was both in vivo as well as ex vivo evaluated.	Caffeine	130-138	poly(ADP-ribose) polymerase 1	Homo sapiens	80-109
20151649-10	2010	When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated.	Caffeine	46-54	ataxia telangiectasia mutated	Mus musculus	59-62
20151649-10	2010	When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated.	Caffeine	46-54	transformation related protein 53, pseudogene	Mus musculus	95-98
20151649-10	2010	When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated.	Caffeine	46-54	transformation related protein 53, pseudogene	Mus musculus	115-118
19889241-1	2010	Caffeine and caffeinated coffee (CC) elicit acute insulin insensitivity when ingested before a carbohydrate load.	Caffeine	0-8	insulin	Homo sapiens	50-57
20139707-4	2010	RyR sensitization with caffeine (250 microM) increased the open probability of single RyR channels, increased the initial frequency and amplitude of local SR Ca(2+) release events (Ca(2+) sparks), and decreased the [Ca(2+)](SR) level where Ca(2+) sparks terminated.	Caffeine	23-31	LOC100009439	Oryctolagus cuniculus	0-3
20139707-4	2010	RyR sensitization with caffeine (250 microM) increased the open probability of single RyR channels, increased the initial frequency and amplitude of local SR Ca(2+) release events (Ca(2+) sparks), and decreased the [Ca(2+)](SR) level where Ca(2+) sparks terminated.	Caffeine	23-31	LOC100009439	Oryctolagus cuniculus	86-89
20007294-7	2010	The minor caffeine-fluvoxamine interaction (1.78-fold) was slightly higher than predicted values based on determination of a moderate f(m) value for CYP1A1, although CYP1A2 may also be involved in caffeine metabolism.	Caffeine	10-18	Cytochrome P450 1A1	Canis lupus familiaris	149-155
20007294-7	2010	The minor caffeine-fluvoxamine interaction (1.78-fold) was slightly higher than predicted values based on determination of a moderate f(m) value for CYP1A1, although CYP1A2 may also be involved in caffeine metabolism.	Caffeine	10-18	cytochrome P450 family 1 subfamily A member 2	Canis lupus familiaris	166-172
20007294-7	2010	The minor caffeine-fluvoxamine interaction (1.78-fold) was slightly higher than predicted values based on determination of a moderate f(m) value for CYP1A1, although CYP1A2 may also be involved in caffeine metabolism.	Caffeine	197-205	cytochrome P450 family 1 subfamily A member 2	Canis lupus familiaris	166-172
20374283-6	2010	Furthermore, we observed a greater caffeine-sensitive basal Ca(2+) store, which was differentially affected when active uptake into the endoplasmic reticulum was blocked, in the presynaptic fields of the Schaffer collateral to CA1 terminals of P6 and younger mice when compared to adults.	Caffeine	35-43	carbonic anhydrase 1	Mus musculus	227-230
20044477-3	2010	Since neuronal and endothelial NO synthase (NOS) are calcium dependent and are also phosphorylated by AMPK, we hypothesized that NOS inhibition would attenuate the activation of mitochondrial biogenesis in response to AICAR and caffeine.	Caffeine	228-236	nitric oxide synthase 2	Homo sapiens	31-42
20044477-7	2010	Caffeine administration, which increased P-CaMK without affecting P-AMPK, increased COX-1, COX-4, PGC-1 alpha, and citrate synthase activity.	Caffeine	0-8	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	43-47
20044477-7	2010	Caffeine administration, which increased P-CaMK without affecting P-AMPK, increased COX-1, COX-4, PGC-1 alpha, and citrate synthase activity.	Caffeine	0-8	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	84-89
20044477-7	2010	Caffeine administration, which increased P-CaMK without affecting P-AMPK, increased COX-1, COX-4, PGC-1 alpha, and citrate synthase activity.	Caffeine	0-8	PPARG coactivator 1 alpha	Homo sapiens	98-109
20044477-7	2010	Caffeine administration, which increased P-CaMK without affecting P-AMPK, increased COX-1, COX-4, PGC-1 alpha, and citrate synthase activity.	Caffeine	0-8	citrate synthase	Homo sapiens	115-131
20044477-8	2010	NOS inhibition, surprisingly, greatly attenuated the effect of caffeine on P-CaMK and attenuated the increases in COX-1 and COX-4 protein.	Caffeine	63-71	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	77-81
20175915-2	2010	Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, for the first time, genotypes for cytochrome P450 1A2 (CYP1A2) associated with metabolism of caffeine.	Caffeine	251-259	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	192-211
20175915-2	2010	Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, for the first time, genotypes for cytochrome P450 1A2 (CYP1A2) associated with metabolism of caffeine.	Caffeine	251-259	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	213-219
20002224-0	2010	Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine.	Caffeine	161-169	Cytochrome P450-6a8	Drosophila melanogaster	84-90
20103623-4	2010	Caffeine, which is known to activate ryanodine receptors, paradoxically inhibits Ca(2+) increase by inositol 1,4,5-trisphospate receptor subtype 3 (IP(3)R3), the expression of which is increased in glioblastoma cells.	Caffeine	0-8	inositol 1,4,5-triphosphate receptor 3	Mus musculus	148-155
20103623-5	2010	Consequently, by inhibiting IP(3)R3-mediated Ca(2+) release, caffeine inhibited migration of glioblastoma cells in various in vitro assays.	Caffeine	61-69	inositol 1,4,5-triphosphate receptor 3	Mus musculus	28-35
20002224-0	2010	Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine.	Caffeine	161-169	Cyp6g1	Drosophila melanogaster	95-101
20002224-1	2010	Many Drosophila cytochrome P450 or Cyp genes are induced by caffeine and phenobarbital (PB).	Caffeine	60-68	disembodied	Drosophila melanogaster	35-38
20002224-5	2010	However, the 0.2-, 0.5- and 0.8-kb DNAs of Cyp6a8 showed 13-24-, 4-5- and 2.2-2.7-fold induction with caffeine, PB and DDT, respectively.	Caffeine	102-110	Cytochrome P450-6a8	Drosophila melanogaster	43-49
20103602-0	2010	Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	153-156
20103602-7	2010	Our study revealed that caffeine and pentoxifylline radiosensitized PTEN-deficient but not PTEN-proficient glioma cells.	Caffeine	24-32	phosphatase and tensin homolog	Homo sapiens	68-72
20103602-8	2010	Radiosensitization of PTEN-deficient U87MG cells by caffeine was significantly correlated with the activation of the G(1) DNA damage checkpoint that occurred independently of de novo synthesis of p53 and p21.	Caffeine	52-60	phosphatase and tensin homolog	Homo sapiens	22-26
20103602-8	2010	Radiosensitization of PTEN-deficient U87MG cells by caffeine was significantly correlated with the activation of the G(1) DNA damage checkpoint that occurred independently of de novo synthesis of p53 and p21.	Caffeine	52-60	H3 histone pseudogene 16	Homo sapiens	204-207
20103602-9	2010	The p53 independency was also confirmed by a significant caffeine-mediated radiosensitization of the glioma cell lines T98G and U373MG that are deficient for both PTEN and p53.	Caffeine	57-65	tumor protein p53	Homo sapiens	4-7
20103602-9	2010	The p53 independency was also confirmed by a significant caffeine-mediated radiosensitization of the glioma cell lines T98G and U373MG that are deficient for both PTEN and p53.	Caffeine	57-65	phosphatase and tensin homolog	Homo sapiens	163-167
20103602-9	2010	The p53 independency was also confirmed by a significant caffeine-mediated radiosensitization of the glioma cell lines T98G and U373MG that are deficient for both PTEN and p53.	Caffeine	57-65	tumor protein p53	Homo sapiens	172-175
20103602-10	2010	Furthermore, caffeine-mediated radiosensitization was associated with the inhibition of Akt hyperphosphorylation in PTEN-deficient cells to a level comparable with PTEN-proficient cells.	Caffeine	13-21	AKT serine/threonine kinase 1	Homo sapiens	88-91
20103602-10	2010	Furthermore, caffeine-mediated radiosensitization was associated with the inhibition of Akt hyperphosphorylation in PTEN-deficient cells to a level comparable with PTEN-proficient cells.	Caffeine	13-21	phosphatase and tensin homolog	Homo sapiens	116-120
20103602-11	2010	Our data suggest that the methylxanthine caffeine or its derivative pentoxifylline are promising candidate drugs for the radiosensitization of glioma cells particularly with PTEN mutations.	Caffeine	41-49	phosphatase and tensin homolog	Homo sapiens	174-178
19879252-2	2010	Caffeine, a non-selective antagonist of adenosine receptors, has been shown to provide protection against myelin oligodendroglia glycoprotein (MOG)-induced EAE in mice.	Caffeine	0-8	myelin oligodendrocyte glycoprotein	Mus musculus	106-141
20074377-10	2010	Blockade of adenosine A(2A) receptor may play an important role in the striatal neuroadaptations observed in the caffeine-sensitized and SCH58261-sensitized mice.	Caffeine	113-121	adenosine A2a receptor	Mus musculus	12-36
19879252-2	2010	Caffeine, a non-selective antagonist of adenosine receptors, has been shown to provide protection against myelin oligodendroglia glycoprotein (MOG)-induced EAE in mice.	Caffeine	0-8	myelin oligodendrocyte glycoprotein	Mus musculus	143-146
19879252-7	2010	Furthermore, it was showed that chronic treatment with caffeine up-regulated A1 receptor and TGF-beta mRNAs and suppressed interferon-gamma mRNA in EAE rats.	Caffeine	55-63	interferon gamma	Rattus norvegicus	123-139
20458147-5	2010	RESULTS: The P300 peak latency was significantly shortened after tooth brushing with the toothpaste containing flavoring and caffeine, compared to that after brushing with toothpaste containing no additives (p&lt;0.01), and prolongation of the P300 peak latency after the calculation task was significantly inhibited (p&lt;0.01).	Caffeine	125-133	E1A binding protein p300	Homo sapiens	13-17
19427413-9	2010	ACPA production has been associated with several genetic predisposing factors, including HLA-DRB1 and PTPN22 1858T alleles, as well as with environmental and lifestyle-related factors, primarily smoking and possibly, the use of oral contraceptives and excessive caffeine intake.	Caffeine	262-270	proteinase 3	Homo sapiens	0-4
21309106-3	2010	Additionally, findings on the adenosine receptor 2A (A2A) gene, which has been reported to be associated with panic disorder and also with anxiety levels after caffeine administration in a gene--environment interactional model, will be discussed.	Caffeine	160-168	immunoglobulin kappa variable 2D-29	Homo sapiens	30-57
20182037-3	2010	AD mice given caffeine in their drinking water from young adulthood into older age showed protection against memory impairment and lower brain levels of the abnormal protein (amyloid-beta; Abeta) thought to be central to AD pathogenesis.	Caffeine	14-22	amyloid beta (A4) precursor protein	Mus musculus	189-194
20182037-6	2010	In acute studies involving AD mice, one oral caffeine treatment quickly reduced both brain and plasma Abeta levels - similarly rapid alterations in plasma Abeta levels were seen in humans following acute caffeine administration.	Caffeine	45-53	amyloid beta (A4) precursor protein	Mus musculus	102-107
20182037-6	2010	In acute studies involving AD mice, one oral caffeine treatment quickly reduced both brain and plasma Abeta levels - similarly rapid alterations in plasma Abeta levels were seen in humans following acute caffeine administration.	Caffeine	45-53	amyloid beta (A4) precursor protein	Mus musculus	155-160
20182037-6	2010	In acute studies involving AD mice, one oral caffeine treatment quickly reduced both brain and plasma Abeta levels - similarly rapid alterations in plasma Abeta levels were seen in humans following acute caffeine administration.	Caffeine	204-212	amyloid beta (A4) precursor protein	Mus musculus	155-160
20182037-7	2010	"Caffeinated" coffee provided to AD mice also quickly decreased plasma Abeta levels, but not "decaffeinated" coffee, suggesting that caffeine is critical to decreasing blood Abeta levels.	Caffeine	133-141	amyloid beta (A4) precursor protein	Mus musculus	174-179
20182037-8	2010	Caffeine appears to provide its disease-modifying effects through multiple mechanisms, including a direct reduction of Abeta production through suppression of both beta- and gamma-secretase levels.	Caffeine	0-8	amyloid beta (A4) precursor protein	Mus musculus	119-124
20164566-3	2010	Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors.	Caffeine	44-52	phosphodiesterase 4A	Homo sapiens	137-141
20164566-3	2010	Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors.	Caffeine	44-52	phosphodiesterase 5A	Homo sapiens	143-147
19782116-11	2010	CSC and CAF (0.1, 1 and 10 microg/ml) produced inhibitions of the MPO release from PMA-stimulated cells, ranging from 45 to 83%.	Caffeine	8-11	myeloperoxidase	Rattus norvegicus	66-69
19782116-14	2010	Furthermore, CSC and caffeine actions, inhibiting MPO as well as LDH releases, would contribute to their possible benefit in the treatment of neurodegenerative diseases, including DP.	Caffeine	21-29	myeloperoxidase	Rattus norvegicus	50-53
20458147-5	2010	RESULTS: The P300 peak latency was significantly shortened after tooth brushing with the toothpaste containing flavoring and caffeine, compared to that after brushing with toothpaste containing no additives (p&lt;0.01), and prolongation of the P300 peak latency after the calculation task was significantly inhibited (p&lt;0.01).	Caffeine	125-133	E1A binding protein p300	Homo sapiens	244-248
20029548-6	2009	Furthermore, reduction in the isoproterenol-, ATP-, ouabain-, and caffeine-induced increases in [Ca(2+)](i) in cardiomyocytes from I/R hearts were limited by treatment with NAC or MPG.	Caffeine	66-74	N-methylpurine-DNA glycosylase	Rattus norvegicus	180-183
19841479-7	2009	SMARCAL1 is phosphorylated in a caffeine-sensitive manner in response to double-stranded breaks and stalled replication forks.	Caffeine	32-40	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1	Homo sapiens	0-8
19735649-7	2009	Release of G2/M arrest by caffeine was accompanied by a decrease in the levels of p53/p21; however, gamma-H2AX levels were unchanged.	Caffeine	26-34	tumor protein p53	Homo sapiens	82-85
19735649-7	2009	Release of G2/M arrest by caffeine was accompanied by a decrease in the levels of p53/p21; however, gamma-H2AX levels were unchanged.	Caffeine	26-34	H3 histone pseudogene 16	Homo sapiens	86-89
19864960-0	2009	Caffeine elicits c-Fos expression in horizontal diagonal band cholinergic neurons.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
19864960-5	2009	Caffeine significantly increased c-Fos expression in cholinergic neurons of the horizontal limb of the diagonal band of Broca but not other basal forebrain regions such as the medial septum or substantia innominata.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-38
20002088-4	2009	* This cocktail can be used to test the effects of a new chemical entity on multiple CYP isoforms in a single clinical study: CYP1A2 (caffeine), CYP2C9 (warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol), and CYP3A (midazolam) and was designed to overcome potential liabilities of other reported cocktails.	Caffeine	134-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
20002088-4	2009	* This cocktail can be used to test the effects of a new chemical entity on multiple CYP isoforms in a single clinical study: CYP1A2 (caffeine), CYP2C9 (warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol), and CYP3A (midazolam) and was designed to overcome potential liabilities of other reported cocktails.	Caffeine	134-142	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	186-192
20002088-4	2009	* This cocktail can be used to test the effects of a new chemical entity on multiple CYP isoforms in a single clinical study: CYP1A2 (caffeine), CYP2C9 (warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol), and CYP3A (midazolam) and was designed to overcome potential liabilities of other reported cocktails.	Caffeine	134-142	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	211-216
20002088-5	2009	AIMS: To assess the pharmacokinetics (PK) of selective substrates of CYP1A2 (caffeine), CYP2C9 (S-warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol) and CYP3A (midazolam) when administered orally and concurrently as a cocktail relative to the drugs administered alone.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	69-75
19894211-4	2010	Consistent with a cell integrity function, mdt1Delta cells are hypersensitive to the cell wall toxin calcofluor white and the Bck1-Slt2 pathway activator caffeine.	Caffeine	154-162	mitogen-activated protein kinase kinase kinase BCK1	Saccharomyces cerevisiae S288C	126-130
19894211-4	2010	Consistent with a cell integrity function, mdt1Delta cells are hypersensitive to the cell wall toxin calcofluor white and the Bck1-Slt2 pathway activator caffeine.	Caffeine	154-162	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	131-135
20043572-4	2009	Caffeine in the form of a soft drink was orally administered as a test probe for CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-87
19952445-6	2009	The second-order rate constants (k") for the caffeine inhibited reactions lie in the range of 0.13 to 5.10x10(-3) M(-1) min(-1).	Caffeine	45-53	CD59 molecule (CD59 blood group)	Homo sapiens	120-126
19940169-12	2009	Together, these results show that A(2A)Rs play a crucial role in the development of Abeta-induced synaptotoxicity leading to memory dysfunction through a p38 MAPK (mitogen-activated protein kinase)-dependent pathway and provide a molecular basis for the benefits of caffeine consumption in AD.	Caffeine	266-274	amyloid beta precursor protein	Rattus norvegicus	84-89
19903334-0	2009	The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.	Caffeine	38-46	ATR serine/threonine kinase	Homo sapiens	12-15
19903334-0	2009	The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.	Caffeine	38-46	cyclin D1	Homo sapiens	56-65
19903334-0	2009	The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.	Caffeine	38-46	ATM serine/threonine kinase	Homo sapiens	4-7
19903334-7	2009	Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB).	Caffeine	39-47	cyclin D1	Homo sapiens	98-107
19903334-9	2009	The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles.	Caffeine	28-36	cyclin D1	Homo sapiens	59-68
19759279-9	2009	Caffeine exposure (5, 20 and 100 microM) in ethanol-naive cultures did not produce toxicity in the DG or CA1 region, but 20 microM caffeine produced modest toxicity in the CA3 region.	Caffeine	131-139	carbonic anhydrase 3	Rattus norvegicus	172-175
19759279-10	2009	Exposure to 20 microM caffeine during EWD produced cytotoxicity in all hippocampal regions, though toxicity was sex-dependent in the DG and CA1 region.	Caffeine	22-30	carbonic anhydrase 1	Rattus norvegicus	140-143
19759279-12	2009	Similarly, 20 microM caffeine caused markedly greater toxicity in female cultures as compared to male cultures in the CA1 region.	Caffeine	21-29	carbonic anhydrase 1	Rattus norvegicus	118-121
19759279-13	2009	CONCLUSIONS: Twenty-four-hour exposure to caffeine during EWD produced significant toxicity in the pyramidal cell layer of the CA3 region in male and female cultures, though toxicity in the granule cell layer of the DG and pyramidal cell layer of the CA1 region was observed only in female cultures.	Caffeine	42-50	carbonic anhydrase 3	Rattus norvegicus	127-130
19759279-13	2009	CONCLUSIONS: Twenty-four-hour exposure to caffeine during EWD produced significant toxicity in the pyramidal cell layer of the CA3 region in male and female cultures, though toxicity in the granule cell layer of the DG and pyramidal cell layer of the CA1 region was observed only in female cultures.	Caffeine	42-50	carbonic anhydrase 1	Rattus norvegicus	251-254
20038063-0	2009	[Study on interaction of caffeine with myoglobin by fluorescence spectroscopy].	Caffeine	25-33	myoglobin	Homo sapiens	39-48
19711421-2	2009	METHODS: Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS).	Caffeine	39-47	fuzzy planar cell polarity protein	Homo sapiens	85-88
19843669-6	2009	CYP1A2 activity was determined by urine caffeine tests administered at baseline and the end of each feeding period.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
19608206-3	2009	We explored whether caffeine acts on skeletal muscle to stimulate AMPK.	Caffeine	20-28	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	66-70
19608206-4	2009	Incubation of rat epitrochlearis and soleus muscles with Krebs buffer containing caffeine (&gt; or =3 mmol/L, &gt; or =15 minutes) increased the phosphorylation of AMPKalpha Thr(172), an essential step for full kinase activation, and acetyl-coenzyme A carboxylase Ser(79), a downstream target of AMPK, in dose- and time-dependent manners.	Caffeine	81-89	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	164-168
19608206-7	2009	These results suggest that caffeine has similar actions to exercise by acutely stimulating skeletal muscle AMPK activity and insulin-independent glucose transport with a reduction of the intracellular energy status.	Caffeine	27-35	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	107-111
19422358-4	2009	Probe drugs used to measure CYP activities were caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4).	Caffeine	48-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-31
19881958-5	2009	Inhibition of ATM by both the pharmacological inhibitor caffeine and the specific small interference RNA (siRNA) rescued the G(2) arrest elicited by R16, indicating its ATM-dependent characteristic.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	14-17
19881958-5	2009	Inhibition of ATM by both the pharmacological inhibitor caffeine and the specific small interference RNA (siRNA) rescued the G(2) arrest elicited by R16, indicating its ATM-dependent characteristic.	Caffeine	56-64	solute carrier family 1 member 5	Homo sapiens	149-152
19881958-5	2009	Inhibition of ATM by both the pharmacological inhibitor caffeine and the specific small interference RNA (siRNA) rescued the G(2) arrest elicited by R16, indicating its ATM-dependent characteristic.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	169-172
20081260-4	2009	A comparative in vitro study provides clear evidence that ticlopidine and DDC, applied at concentrations that inhibit the above-mentioned CYP isoforms, potently (as compared to furafylline) inhibit human CYP1A2 and caffeine metabolism, in particular 1-N- and 3-N-demethylation.	Caffeine	215-223	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	138-141
19765987-8	2009	Gr33a mutant flies were impaired in avoiding all nonvolatile repellents tested, ranging from quinine to denatonium, lobeline, and caffeine.	Caffeine	130-138	Gustatory receptor 33a	Drosophila melanogaster	0-5
19785652-7	2009	Rapamycin which displaces FKBP (to inhibit mTOR) also increased the amplitude of the caffeine-evoked, but reduced the IP(3)-evoked [Ca(2+)](cyto) rise.	Caffeine	85-93	mechanistic target of rapamycin kinase	Homo sapiens	43-47
19738435-4	2009	We also document that re-growth of CSCs can be greatly delayed if lung tumor cells are treated with drug/caffeine combination that leads to the inhibition of the ATM/ATR pathway and decreased phosphorylation of PKB/Akt at Ser473.	Caffeine	105-113	ATM serine/threonine kinase	Homo sapiens	162-165
19738435-4	2009	We also document that re-growth of CSCs can be greatly delayed if lung tumor cells are treated with drug/caffeine combination that leads to the inhibition of the ATM/ATR pathway and decreased phosphorylation of PKB/Akt at Ser473.	Caffeine	105-113	ATR serine/threonine kinase	Homo sapiens	166-169
20038063-1	2009	The interaction of caffein and myoglobin was investigated by fluorescence spectroscopy and synchronous fluorescence spectroscopy.	Caffeine	19-26	myoglobin	Homo sapiens	31-40
20038063-2	2009	The intrinsic fluorescence of myoglobin was significantly quenched by caffein under the physiological condition (pH 7.4).	Caffeine	70-77	myoglobin	Homo sapiens	30-39
20038063-3	2009	The results indicated that caffeine was capable of binding with myoglobin to form a 1:1 complex and the quenching mechanism of myoglobin affected by caffeine was shown to be a static quenching procedure by calculating quenching constant, binding sites and binding constant.	Caffeine	27-35	myoglobin	Homo sapiens	64-73
20038063-3	2009	The results indicated that caffeine was capable of binding with myoglobin to form a 1:1 complex and the quenching mechanism of myoglobin affected by caffeine was shown to be a static quenching procedure by calculating quenching constant, binding sites and binding constant.	Caffeine	27-35	myoglobin	Homo sapiens	127-136
20038063-3	2009	The results indicated that caffeine was capable of binding with myoglobin to form a 1:1 complex and the quenching mechanism of myoglobin affected by caffeine was shown to be a static quenching procedure by calculating quenching constant, binding sites and binding constant.	Caffeine	149-157	myoglobin	Homo sapiens	64-73
20038063-3	2009	The results indicated that caffeine was capable of binding with myoglobin to form a 1:1 complex and the quenching mechanism of myoglobin affected by caffeine was shown to be a static quenching procedure by calculating quenching constant, binding sites and binding constant.	Caffeine	149-157	myoglobin	Homo sapiens	127-136
20449175-5	2009	A comparative in vivo study between the known caffeine derived silver carbene SCC1 and SCC8 demonstrated the ability of both complexes to improve the survival rates of mice in a pneumonia model utilizing the clinically isolated infectious strain of Pseudomonas aeruginosa PA M57-15.	Caffeine	46-54	protein tyrosine phosphatase, receptor type, J	Mus musculus	78-82
19797863-6	2009	The result showed that caffeine gave a completely negative result on a mutation test for both Tk and Hprt.	Caffeine	23-31	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	101-105
19705844-6	2009	The specific ATM inhibitor caffeine significantly decreased tricetin-mediated G2/M arrest by inhibiting the phosphorylation of p53 (serine 15) and Chk2.	Caffeine	27-35	ATM serine/threonine kinase	Homo sapiens	13-16
19705844-6	2009	The specific ATM inhibitor caffeine significantly decreased tricetin-mediated G2/M arrest by inhibiting the phosphorylation of p53 (serine 15) and Chk2.	Caffeine	27-35	tumor protein p53	Homo sapiens	127-130
19705844-6	2009	The specific ATM inhibitor caffeine significantly decreased tricetin-mediated G2/M arrest by inhibiting the phosphorylation of p53 (serine 15) and Chk2.	Caffeine	27-35	checkpoint kinase 2	Homo sapiens	147-151
19631929-4	2009	PTX-3 determined by enzyme-linked immunosorbent assay was related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine, and uterine/umbilical artery Doppler pulsatility index (PI).	Caffeine	164-172	pentraxin 3	Homo sapiens	0-5
19713762-6	2009	Cells expressing stabilized Hsl1 were sensitive to caffeine and failed to activate the Slt2 pathway.	Caffeine	51-59	decapping enzyme, scavenger	Homo sapiens	28-32
19725982-4	2009	In the caffeine-treated rats with ventriculomegaly, there was increased production of CSF, associated with the increased expression of Na(+), K(+)-ATPase and increased cerebral blood flow (CBF).	Caffeine	7-15	colony stimulating factor 2	Rattus norvegicus	86-89
19725982-5	2009	In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting "effect inversion" associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine.	Caffeine	57-65	colony stimulating factor 2	Rattus norvegicus	94-97
19725982-5	2009	In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting "effect inversion" associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine.	Caffeine	145-153	colony stimulating factor 2	Rattus norvegicus	94-97
19725982-5	2009	In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting "effect inversion" associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine.	Caffeine	145-153	colony stimulating factor 2	Rattus norvegicus	94-97
19725982-7	2009	CONCLUSION: The results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF.	Caffeine	73-81	colony stimulating factor 2	Rattus norvegicus	164-167
19726661-0	2009	The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor.	Caffeine	15-23	Protein kinase, cAMP-dependent, catalytic subunit 2	Drosophila melanogaster	55-58
19726661-8	2009	Finally, the effects of caffeine on sleep are blocked in flies that have reduced neuronal PKA activity.	Caffeine	24-32	Protein kinase, cAMP-dependent, catalytic subunit 2	Drosophila melanogaster	90-93
19576520-0	2009	Early long-term exposure with caffeine induces cross-sensitization to methylphenidate with involvement of DARPP-32 in adulthood of rats.	Caffeine	30-38	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	106-114
19298530-5	2009	The use of antisense oligonucleotide directed against RYR sub-types indicated that caffeine-induced Ca(2+) response and Ca(2+) spark frequency depended on RYR2 and RYR1.	Caffeine	83-91	ryanodine receptor 1, skeletal muscle	Mus musculus	54-57
19298530-5	2009	The use of antisense oligonucleotide directed against RYR sub-types indicated that caffeine-induced Ca(2+) response and Ca(2+) spark frequency depended on RYR2 and RYR1.	Caffeine	83-91	ryanodine receptor 2, cardiac	Mus musculus	155-159
19298530-5	2009	The use of antisense oligonucleotide directed against RYR sub-types indicated that caffeine-induced Ca(2+) response and Ca(2+) spark frequency depended on RYR2 and RYR1.	Caffeine	83-91	ryanodine receptor 1, skeletal muscle	Mus musculus	164-168
19928580-0	2009	[On the possibility of patient phenotyping on the basis of cytochrome p-450 1A2 isoenzyme activity using caffeine as the test substrate].	Caffeine	105-113	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-79
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	cellular communication network factor 2	Homo sapiens	273-277
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	cellular communication network factor 2	Homo sapiens	278-282
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	SMAD family member 2	Homo sapiens	368-373
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	SMAD family member 3	Homo sapiens	403-408
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	transforming growth factor beta 1	Homo sapiens	433-464
19610047-4	2009	New results indicate that the methylxanthine caffeine--a major component of coffee and the most widely consumed pharmacologically active substance in the world--might be responsible for this phenomenon, because it inhibits the synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal and nonparenchymal cells, primarily by inducing degradation of Smad2 (and to a much lesser extent Smad3) and thus impairment of transforming growth factor beta (TGF-beta) signaling.	Caffeine	45-53	transforming growth factor beta 1	Homo sapiens	466-474
19576520-4	2009	Previous studies have suggested that dopamine- and cAMP-regulated phosphoproteins of 32 kDa (DARPP-32) participate in the manifestation of behavioral activity following ingestion of caffeine or MPH.	Caffeine	182-190	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	37-91
19576520-4	2009	Previous studies have suggested that dopamine- and cAMP-regulated phosphoproteins of 32 kDa (DARPP-32) participate in the manifestation of behavioral activity following ingestion of caffeine or MPH.	Caffeine	182-190	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	93-101
19576520-10	2009	The behavioral effect observed was accompanied by increased levels of DARPP-32 in the striatum and prefrontal cortex compared to control groups (saline or caffeine).	Caffeine	155-163	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	70-78
19576520-12	2009	In conclusion, chronic caffeine exposure induces likely long-term cross-sensitization to MPH in a DARPP-32-dependent pathway.	Caffeine	23-31	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	98-106
19490937-5	2009	The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3.	Caffeine	73-81	cathepsin B	Homo sapiens	179-190
19904008-2	2009	Moreover, the influence of perazine on other caffeine metabolic pathways such as 7-N-demethylation (CYP1A2, CYP2C8/9, CYP3A4) and 8-hydroxylation (CYP3A4, CYP1A2, CYP2C8/9) was also determined.	Caffeine	45-53	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
19904008-3	2009	The Dixon analysis showed that in both human liver microsomes and Supersomes CYP1A2 perazine potently and to a similar degree inhibited caffeine 3-N-demethylation (K(i) = 3.5 microM) and 1-N-demethylation (K(i) = 5 microM).	Caffeine	136-144	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
19904008-4	2009	Perazine moderately diminished the rate of caffeine 7-N-demethylation in Supersomes CYP1A2 (K(i) = 11.5 microM) and liver microsomes (K(i) = 20 microM), and attenuated C-8-hydroxylation (K(i) = 15.5 microM) in Supersomes CYP1A2.	Caffeine	43-51	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	84-90
19490937-5	2009	The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3.	Caffeine	73-81	poly(ADP-ribose) polymerase 1	Homo sapiens	206-210
19490937-5	2009	The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3.	Caffeine	73-81	caspase 3	Homo sapiens	227-236
19520064-0	2009	Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.	Caffeine	10-18	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	40-59
19520064-0	2009	Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.	Caffeine	10-18	adenosine A2a receptor	Mus musculus	61-83
19520064-8	2009	Caffeine partially protected MPTP-induced neurodegenerative changes and modulated MPTP-mediated alterations in the expression and catalytic activity of CYP1A2, expression of adenosine A(2A) receptor and DAT.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	152-158
19520064-8	2009	Caffeine partially protected MPTP-induced neurodegenerative changes and modulated MPTP-mediated alterations in the expression and catalytic activity of CYP1A2, expression of adenosine A(2A) receptor and DAT.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	174-198
19520064-0	2009	Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.	Caffeine	10-18	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	88-108
19520064-8	2009	Caffeine partially protected MPTP-induced neurodegenerative changes and modulated MPTP-mediated alterations in the expression and catalytic activity of CYP1A2, expression of adenosine A(2A) receptor and DAT.	Caffeine	0-8	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	203-206
19520064-9	2009	The results demonstrate that caffeine alters the striatal CYP1A2, adenosine A(2A) receptor and DAT expressions in mice exposed to MPTP.	Caffeine	29-37	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	58-64
19520064-3	2009	Cytochrome P450 1A2 (CYP1A2) is involved in caffeine metabolism and its clearance.	Caffeine	44-52	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	0-19
19520064-9	2009	The results demonstrate that caffeine alters the striatal CYP1A2, adenosine A(2A) receptor and DAT expressions in mice exposed to MPTP.	Caffeine	29-37	adenosine A2a receptor	Mus musculus	66-90
19520064-9	2009	The results demonstrate that caffeine alters the striatal CYP1A2, adenosine A(2A) receptor and DAT expressions in mice exposed to MPTP.	Caffeine	29-37	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	95-98
19520064-3	2009	Cytochrome P450 1A2 (CYP1A2) is involved in caffeine metabolism and its clearance.	Caffeine	44-52	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	21-27
19520064-4	2009	Caffeine, on the other hand, antagonizes adenosine A(2A) receptor and regulates dopamine signaling through dopamine transporter (DAT).	Caffeine	0-8	adenosine A2a receptor	Mus musculus	41-65
19520064-4	2009	Caffeine, on the other hand, antagonizes adenosine A(2A) receptor and regulates dopamine signaling through dopamine transporter (DAT).	Caffeine	0-8	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	107-127
19520064-4	2009	Caffeine, on the other hand, antagonizes adenosine A(2A) receptor and regulates dopamine signaling through dopamine transporter (DAT).	Caffeine	0-8	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	129-132
19215233-7	2009	Urinary caffeine metabolite ratios were used as indicators of the activity of CYP1A2, CYP2A6, NAT2 and XO.	Caffeine	8-16	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p &lt; 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p &lt; 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p &lt; 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p &lt; 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p &lt; 0.05) in younger women, whereas depression decreased (p &lt; or = 0.05) in older women.	Caffeine	31-39	selenium binding protein 1	Homo sapiens	99-102
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p &lt; 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p &lt; 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p &lt; 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p &lt; 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p &lt; 0.05) in younger women, whereas depression decreased (p &lt; or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	107-110
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p &lt; 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p &lt; 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p &lt; 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p &lt; 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p &lt; 0.05) in younger women, whereas depression decreased (p &lt; or = 0.05) in older women.	Caffeine	31-39	selenium binding protein 1	Homo sapiens	184-187
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p &lt; 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p &lt; 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p &lt; 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p &lt; 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p &lt; 0.05) in younger women, whereas depression decreased (p &lt; or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	235-238
19767812-5	2009	Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p &lt; 0.05) in the older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p &lt; 0.05); (ii) heart rate decreased significantly (Y, 59.2 +/- 8.7 to 53.9 +/- 10.6 beats.min-1 (p &lt; 0.05); O, 61.9 +/- 9.2 to 59.2 +/- 8.4 beats.min-1 (p &lt; 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p &lt; 0.05) in younger women, whereas depression decreased (p &lt; or = 0.05) in older women.	Caffeine	31-39	D-box binding PAR bZIP transcription factor	Homo sapiens	235-238
19767812-6	2009	Self-reported level of physical activity was inversely related to change in DBP following caffeine ingestion in younger women.	Caffeine	90-98	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79
19451294-2	2009	The development of a compound composed of silver coupled to a methylated caffeine carrier (silver carbene complex 1 [SCC1]) that demonstrated in vitro efficacy against bacteria, including drug-resistant organisms, isolated from patients with respiratory tract infections was described previously.	Caffeine	73-81	RAD21 cohesin complex component	Homo sapiens	91-115
19451294-2	2009	The development of a compound composed of silver coupled to a methylated caffeine carrier (silver carbene complex 1 [SCC1]) that demonstrated in vitro efficacy against bacteria, including drug-resistant organisms, isolated from patients with respiratory tract infections was described previously.	Caffeine	73-81	RAD21 cohesin complex component	Homo sapiens	117-121
19508875-1	2009	AIMS: Our previous work revealed that mice lacking the p50 subunit of transcription factor nuclear factor kappa B (NF-kappaB) (p50 KO mice) and genetically intact F2 mice have similar locomotion under basal conditions, yet p50 KO mice show greater locomotor activation after caffeine ingestion.	Caffeine	275-283	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-58
19221177-10	2009	Consistent with these results, caffeine-treated WT or A(2A)R(-/-) mice had reduced submesothelial thickness, collagen deposition and mRNA levels of fibroblast-specific protein (FSP-1) and connective tissue growth factor (CTGF).	Caffeine	31-39	atlastin GTPase 1	Mus musculus	177-182
19221177-10	2009	Consistent with these results, caffeine-treated WT or A(2A)R(-/-) mice had reduced submesothelial thickness, collagen deposition and mRNA levels of fibroblast-specific protein (FSP-1) and connective tissue growth factor (CTGF).	Caffeine	31-39	cellular communication network factor 2	Mus musculus	188-219
19221177-10	2009	Consistent with these results, caffeine-treated WT or A(2A)R(-/-) mice had reduced submesothelial thickness, collagen deposition and mRNA levels of fibroblast-specific protein (FSP-1) and connective tissue growth factor (CTGF).	Caffeine	31-39	cellular communication network factor 2	Mus musculus	221-225
19539527-4	2009	Patients with disorders characterized by excessive inflammation may be at risk to A2AR antagonists (e.g. caffeine) because of the effect to increase inflammatory damage secondary to enhanced immunity.	Caffeine	105-113	adenosine A2a receptor	Homo sapiens	82-86
19451835-2	2009	Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine.	Caffeine	82-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19
19451835-2	2009	Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine.	Caffeine	82-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
19403289-2	2009	The effects of Danshen and tanshinones on CYP1A2 activity was determined by metabolism of model substrates in vitro (phenacetin) and in vivo (caffeine).	Caffeine	142-150	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	42-48
19242509-0	2009	ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.	Caffeine	147-155	ATR serine/threonine kinase	Homo sapiens	0-3
19502790-4	2009	In contrast, caffeine treatment specifically increased IR-induced chromosome aberrations and mitotic index only in cells with PTEN, and not in cells deficient for PTEN, suggesting that their checkpoints were defective.	Caffeine	13-21	phosphatase and tensin homolog	Homo sapiens	126-130
19321391-9	2009	Removal of p21 was not required for NER activity, since inhibition of p21 degradation by caffeine did not affect the UV-induced recruitment of repair proteins, such as PCNA and DNA polymerase delta, nor significantly influence DNA repair synthesis, as determined by autoradiography.	Caffeine	89-97	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-73
21783975-3	2009	New results indicate that the methylxanthine caffeine, major component of coffee and the most widely consumed pharmacologically active substance in the world, might be responsible for this phenomenon as it, and even more potently its derived primary metabolite paraxanthine, inhibits transforming growth factor (TGF)-beta-dependent and -independent synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal cells in vitro and in vivo.	Caffeine	45-53	cellular communication network factor 2	Homo sapiens	395-399
21783975-3	2009	New results indicate that the methylxanthine caffeine, major component of coffee and the most widely consumed pharmacologically active substance in the world, might be responsible for this phenomenon as it, and even more potently its derived primary metabolite paraxanthine, inhibits transforming growth factor (TGF)-beta-dependent and -independent synthesis of connective tissue growth factor (CTGF/CCN2) in liver parenchymal cells in vitro and in vivo.	Caffeine	45-53	cellular communication network factor 2	Homo sapiens	400-404
21783975-5	2009	This article summarizes the clinical-epidemiological observations as well as the pathophysiological background of the antifibrotic effects of coffee consumption and provides suggestions for the therapeutic use of caffeine and its derived metabolic methylxanthines as potentially powerful drugs in patients with chronic fibrogenic liver disease by their inhibitory effect on (hepatocellular) CTGF synthesis.	Caffeine	213-221	cellular communication network factor 2	Homo sapiens	391-395
19242509-0	2009	ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.	Caffeine	147-155	checkpoint kinase 1	Homo sapiens	4-8
19242509-10	2009	These data suggest that a relevant target of caffeine is the ATR-Chk1 pathway and that inhibiting ATR or Chk1 might have promise in preventing or reversing UV damage.	Caffeine	45-53	ATR serine/threonine kinase	Homo sapiens	61-64
19242509-10	2009	These data suggest that a relevant target of caffeine is the ATR-Chk1 pathway and that inhibiting ATR or Chk1 might have promise in preventing or reversing UV damage.	Caffeine	45-53	checkpoint kinase 1	Homo sapiens	65-69
19242509-10	2009	These data suggest that a relevant target of caffeine is the ATR-Chk1 pathway and that inhibiting ATR or Chk1 might have promise in preventing or reversing UV damage.	Caffeine	45-53	ATR serine/threonine kinase	Homo sapiens	98-101
19242509-10	2009	These data suggest that a relevant target of caffeine is the ATR-Chk1 pathway and that inhibiting ATR or Chk1 might have promise in preventing or reversing UV damage.	Caffeine	45-53	checkpoint kinase 1	Homo sapiens	105-109
19291178-0	2009	Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.	Caffeine	50-58	cellular communication network factor 2	Homo sapiens	80-111
19291178-2	2009	Based on reports of a hepatoprotective effect of coffee consumption, we were the first to provide evidence that caffeine suppresses transforming growth factor (TGF)-beta dependent and -independent CTGF expression in hepatocytes in vitro and in vivo, thus suggesting this xanthine-alkaloid as a potential therapeutic agent.	Caffeine	112-120	transforming growth factor beta 1	Homo sapiens	160-169
19291178-2	2009	Based on reports of a hepatoprotective effect of coffee consumption, we were the first to provide evidence that caffeine suppresses transforming growth factor (TGF)-beta dependent and -independent CTGF expression in hepatocytes in vitro and in vivo, thus suggesting this xanthine-alkaloid as a potential therapeutic agent.	Caffeine	112-120	cellular communication network factor 2	Homo sapiens	197-201
19291178-3	2009	AIM: This study aims at comparing the inhibitory capacities of caffeine and its three demethylated derivates paraxanthine, theophylline and theobromine on CTGF expression in hepatocytes and hepatic stellate cells (HSC).	Caffeine	63-71	cellular communication network factor 2	Homo sapiens	155-159
19291178-4	2009	RESULTS: Our data suggest paraxanthine as the most important pharmacological repressor of hepatocellular CTGF expression among the caffeine-derived metabolic methylxanthines with an inhibitory dosage (ID)50 of 1.15 mM, i.e. 3.84-fold lower than what is observed for caffeine.	Caffeine	131-139	cellular communication network factor 2	Homo sapiens	105-109
19291178-9	2009	CONCLUSION: Our data provide an evidence-based suggestion of the caffeine-derived primary metabolite paraxanthine as a potentially powerful antifibrotic drug by its inhibitory effect on (hepatocellular) CTGF synthesis.	Caffeine	65-73	cellular communication network factor 2	Homo sapiens	203-207
19536869-6	2009	The specific ATM inhibitor caffeine significantly decreased ISL-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	27-35	ATM serine/threonine kinase	Homo sapiens	13-16
19199006-7	2009	These observations suggest that caffeine can induce Ca2+ influx by activating TRPV1 channels.	Caffeine	32-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
19536869-6	2009	The specific ATM inhibitor caffeine significantly decreased ISL-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	27-35	tumor protein p53	Homo sapiens	122-125
19536869-6	2009	The specific ATM inhibitor caffeine significantly decreased ISL-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	27-35	checkpoint kinase 2	Homo sapiens	141-145
19534587-2	2009	Using caffeine as a probe drug, this project was designed to investigate the effect of STS on the activity of CYP1A2 in humans.	Caffeine	6-14	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	110-116
19289172-0	2009	Caffeine dose effect on activation-induced BOLD and CBF responses.	Caffeine	0-8	CCAAT enhancer binding protein zeta	Homo sapiens	52-55
19289172-7	2009	The maximum increase in CBF response was associated with the highest caffeine dose of 5 mg/kg.	Caffeine	69-77	CCAAT enhancer binding protein zeta	Homo sapiens	24-27
19534587-6	2009	CYP1A2 activity was monitored by the ratio of paraxanthine to caffeine at 6 h in plasma.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
19808480-8	2009	The CaMKII-inhibitor KN93 reversed CAVB-induced changes in caffeine-releasable [Ca(2+)](i) and I(CaL) inactivation voltage and suppressed CAVB-induced EADs.	Caffeine	59-67	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	4-10
19536434-9	2009	There was a detectable degradation of TnI in soleus after 10 mmol/L caffeine treatment.	Caffeine	68-76	troponin I3, cardiac type	Rattus norvegicus	38-41
19384973-7	2009	Among the postmenopausal women, there was a positive association between caffeine and coffee intake and SHBG levels (P-trend = .03 and .06, respectively).	Caffeine	73-81	sex hormone binding globulin	Homo sapiens	104-108
19384973-9	2009	CONCLUSIONS: Data from this cross-sectional study suggest that caffeine may alter circulating levels of luteal estrogens and SHBG, representing possible mechanisms by which coffee or caffeine may be associated with pre- and postmenopausal malignancies, respectively.	Caffeine	63-71	sex hormone binding globulin	Homo sapiens	125-129
19384973-9	2009	CONCLUSIONS: Data from this cross-sectional study suggest that caffeine may alter circulating levels of luteal estrogens and SHBG, representing possible mechanisms by which coffee or caffeine may be associated with pre- and postmenopausal malignancies, respectively.	Caffeine	183-191	sex hormone binding globulin	Homo sapiens	125-129
19554099-6	2009	In DU-145 cells, inhibition of Ca(2+) release was apparent following treatment with Ringers containing RyR agonists cADPR, 4CmC or caffeine and respective levels of BA (50 microM), (1, 10 microM) or (10, 20, 50,150 microM).	Caffeine	131-139	ryanodine receptor 2	Homo sapiens	103-106
19374031-6	2009	Gtr1p and Gtr2p are necessary for cells to acquire resistance to caffeine, rapamycin, and hydrogen peroxide.	Caffeine	65-73	Rag GTPase GTR1	Saccharomyces cerevisiae S288C	0-5
19324081-7	2009	Inhibition of ATM with caffeine, KU-55933, or siRNA or inhibition of the MEK/ERK pathway can block the LDR-induced NF-kappaB activation and eliminate the LDR-induced survival advantage.	Caffeine	23-31	ATM serine/threonine kinase	Homo sapiens	14-17
19194991-4	2009	Mouse ES cells expressed the A(1), A(2A), A(2B), and A(3) adenosine receptors (ARs), whose expression levels were increased by NECA and NECA-induced increase of IL-6 mRNA expression or secretion level was inhibited by the non-specific AR inhibitor, caffeine.	Caffeine	249-257	interleukin 6	Mus musculus	161-165
19194991-5	2009	NECA increased Akt and protein kinase C (PKC) phosphorylation, intracellular Ca(2+) and cyclic adenosine monophosphate (cAMP) levels, which were blocked by caffeine.	Caffeine	156-164	thymoma viral proto-oncogene 1	Mus musculus	15-18
19636685-4	2009	We here report the effects of RyR1 modulators like ryanodine, caffeine and dantrolene on the ATP binding of RyR1 using the same technique.	Caffeine	62-70	ryanodine receptor 1	Homo sapiens	30-34
19636685-4	2009	We here report the effects of RyR1 modulators like ryanodine, caffeine and dantrolene on the ATP binding of RyR1 using the same technique.	Caffeine	62-70	ryanodine receptor 1	Homo sapiens	108-112
19636685-5	2009	We present evidence that the exogenous effectors induce changes within RyR1 that lead to different ATP binding characteristics: In the presence of the activating modulator, caffeine, or in the presence of ryanodine, which causes a half-open state of the channel, binding of eight ATP per RyR1 was observed, even in the presence of inhibitory Ca2+, suggestive of a stable "open" channel conformation.	Caffeine	173-181	ryanodine receptor 1	Homo sapiens	71-75
19237502-7	2009	In vitro studies indicate that CASQ1-null muscle exhibits increased contractile sensitivity to temperature and caffeine, temperature-dependent increases in resting Ca(2+), and an increase in the magnitude of depolarization-induced Ca(2+) release.	Caffeine	111-119	calsequestrin 1	Mus musculus	31-36
19261750-6	2009	Caffeine and wortmannin, which are broad-spectrum inhibitors of ATM and ATR, reduced this phosphorylation.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	64-67
19261750-6	2009	Caffeine and wortmannin, which are broad-spectrum inhibitors of ATM and ATR, reduced this phosphorylation.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	72-75
19169672-0	2009	Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice.	Caffeine	0-8	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	140-148
19414815-9	2009	Although the DNA damage response pathways mediated by ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) signaling had been reported to up-regulate NKG2D ligand expression, we found that ULBP1 up-regulation was not inhibited by caffeine and wortmannin, inhibitors of ATM/ATR signaling.	Caffeine	245-253	ATM serine/threonine kinase	Homo sapiens	54-57
19414815-9	2009	Although the DNA damage response pathways mediated by ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) signaling had been reported to up-regulate NKG2D ligand expression, we found that ULBP1 up-regulation was not inhibited by caffeine and wortmannin, inhibitors of ATM/ATR signaling.	Caffeine	245-253	UL16 binding protein 1	Homo sapiens	204-209
19414815-9	2009	Although the DNA damage response pathways mediated by ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) signaling had been reported to up-regulate NKG2D ligand expression, we found that ULBP1 up-regulation was not inhibited by caffeine and wortmannin, inhibitors of ATM/ATR signaling.	Caffeine	245-253	ATM serine/threonine kinase	Homo sapiens	100-103
19414815-9	2009	Although the DNA damage response pathways mediated by ATM (ataxia-telangiectasia, mutated) and ATR (ATM and Rad3-related) signaling had been reported to up-regulate NKG2D ligand expression, we found that ULBP1 up-regulation was not inhibited by caffeine and wortmannin, inhibitors of ATM/ATR signaling.	Caffeine	245-253	ATR serine/threonine kinase	Homo sapiens	95-98
19374031-6	2009	Gtr1p and Gtr2p are necessary for cells to acquire resistance to caffeine, rapamycin, and hydrogen peroxide.	Caffeine	65-73	Gtr2p	Saccharomyces cerevisiae S288C	10-15
19374031-7	2009	Caffeine treatment released Gtr1p from the high molecular weight Gtr1p-Gtr2p complex.	Caffeine	0-8	Rag GTPase GTR1	Saccharomyces cerevisiae S288C	28-33
19374031-7	2009	Caffeine treatment released Gtr1p from the high molecular weight Gtr1p-Gtr2p complex.	Caffeine	0-8	Rag GTPase GTR1	Saccharomyces cerevisiae S288C	65-70
19374031-7	2009	Caffeine treatment released Gtr1p from the high molecular weight Gtr1p-Gtr2p complex.	Caffeine	0-8	Gtr2p	Saccharomyces cerevisiae S288C	71-76
19506935-5	2009	Using the CB(1) cannabinoid receptor agonist ACPA (1 microM) reduced the maximum tension of caffeine contractures by 68.70 +/- 11.63% (P = 0.01, n = 5); tension-time integral was reduced by 66.82 +/- 6.89% (P = 0.02, n = 5) compared to controls.	Caffeine	92-100	proteinase 3	Homo sapiens	45-49
19364474-6	2009	Moreover, caffeine, a known ATR kinase inhibitor, abrogated the cEPA-induced G1 checkpoint in HCT116 cells.	Caffeine	10-18	ATR serine/threonine kinase	Homo sapiens	28-31
19342888-11	2009	Finally, G(2)/M checkpoint activation in response to the expression of the CtIP RFTS is abrogated by caffeine treatment.	Caffeine	101-109	RB binding protein 8, endonuclease	Homo sapiens	75-79
19519341-0	2009	Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62
19519341-0	2009	Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	64-85
19519341-0	2009	Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	108-114
19519341-2	2009	The caffeine metabolic ratio, in urine, plasma or saliva, has been used extensively as an index of CYP1A2, N-acetyltransferase 2 (NAT2), xanthine oxidase (XO) and CYP2A6 enzymatic activities.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	99-105
19519341-2	2009	The caffeine metabolic ratio, in urine, plasma or saliva, has been used extensively as an index of CYP1A2, N-acetyltransferase 2 (NAT2), xanthine oxidase (XO) and CYP2A6 enzymatic activities.	Caffeine	4-12	N-acetyltransferase 2	Homo sapiens	107-128
19519341-2	2009	The caffeine metabolic ratio, in urine, plasma or saliva, has been used extensively as an index of CYP1A2, N-acetyltransferase 2 (NAT2), xanthine oxidase (XO) and CYP2A6 enzymatic activities.	Caffeine	4-12	N-acetyltransferase 2	Homo sapiens	130-134
19519341-2	2009	The caffeine metabolic ratio, in urine, plasma or saliva, has been used extensively as an index of CYP1A2, N-acetyltransferase 2 (NAT2), xanthine oxidase (XO) and CYP2A6 enzymatic activities.	Caffeine	4-12	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	163-169
19519341-3	2009	Phenotyping using plasma or saliva samples to measure the paraxanthine to caffeine (17X/137X) ratio correlates well with many measures of CYP1A2 activity.	Caffeine	74-82	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	138-144
19519341-7	2009	Caffeine has been used by different groups to evaluate the in vivo activity of CYP1A2, NAT2, XO and CYP2A6 in different populations and the effect of many factors on these activities.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
19519341-7	2009	Caffeine has been used by different groups to evaluate the in vivo activity of CYP1A2, NAT2, XO and CYP2A6 in different populations and the effect of many factors on these activities.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	87-91
19321219-0	2009	Intraperitoneal application of caffeine prevents D-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat.	Caffeine	31-39	cellular communication network factor 2	Rattus norvegicus	95-126
19321219-0	2009	Intraperitoneal application of caffeine prevents D-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat.	Caffeine	31-39	cellular communication network factor 2	Rattus norvegicus	128-132
19439589-11	2009	The Ca(2+)(i) response of SCN cells to the RyR agonist caffeine was reduced in BMAL1(-/-) compared with BMAL1(+/+) mice.	Caffeine	55-63	ryanodine receptor 1, skeletal muscle	Mus musculus	43-46
19439589-11	2009	The Ca(2+)(i) response of SCN cells to the RyR agonist caffeine was reduced in BMAL1(-/-) compared with BMAL1(+/+) mice.	Caffeine	55-63	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	79-84
19439589-11	2009	The Ca(2+)(i) response of SCN cells to the RyR agonist caffeine was reduced in BMAL1(-/-) compared with BMAL1(+/+) mice.	Caffeine	55-63	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	104-109
19519341-7	2009	Caffeine has been used by different groups to evaluate the in vivo activity of CYP1A2, NAT2, XO and CYP2A6 in different populations and the effect of many factors on these activities.	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	100-106
19506935-6	2009	When the CB(1) receptor antagonist AM281 was coapplied with ACPA, it reversed the effect of ACPA on caffeine-evoked tension.	Caffeine	100-108	proteinase 3	Homo sapiens	60-64
19506935-6	2009	When the CB(1) receptor antagonist AM281 was coapplied with ACPA, it reversed the effect of ACPA on caffeine-evoked tension.	Caffeine	100-108	proteinase 3	Homo sapiens	92-96
19273591-6	2009	Epitasis analysis indicates that the mutation of SIT4 or TIP41, encoding a Tap42-interacting protein, abolishes the sensitivity of the ptc1 strain to rapamycin and caffeine.	Caffeine	164-172	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	49-53
19018984-3	2009	Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression.	Caffeine	59-67	peroxisome proliferator activated receptor gamma	Homo sapiens	96-144
19018984-3	2009	Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression.	Caffeine	59-67	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
19018984-3	2009	Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression.	Caffeine	59-67	cellular communication network factor 2	Homo sapiens	310-314
19273591-1	2009	Yeast ptc1 mutants are rapamycin and caffeine sensitive, suggesting a functional connection between Ptc1 and the TOR pathway that is not shared by most members of the type 2C phosphatase family.	Caffeine	37-45	type 2C protein phosphatase PTC1	Saccharomyces cerevisiae S288C	6-10
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Caffeine	14-22	activation induced cytidine deaminase	Homo sapiens	47-50
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Caffeine	14-22	activation induced cytidine deaminase	Homo sapiens	97-100
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Caffeine	155-163	activation induced cytidine deaminase	Homo sapiens	47-50
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Caffeine	155-163	activation induced cytidine deaminase	Homo sapiens	97-100
19297526-4	2009	MIC elongation following Spo11p-induced DSBs or artificially induced DNA lesions is probably a DNA-damage response mediated by a phosphokinase signal transduction pathway, since it is suppressed by the ATM/ATR kinase inhibitors caffeine and wortmannin and by knocking out Tetrahymena"s ATR orthologue.	Caffeine	228-236	SPO11 initiator of meiotic double stranded breaks	Homo sapiens	25-31
19297526-4	2009	MIC elongation following Spo11p-induced DSBs or artificially induced DNA lesions is probably a DNA-damage response mediated by a phosphokinase signal transduction pathway, since it is suppressed by the ATM/ATR kinase inhibitors caffeine and wortmannin and by knocking out Tetrahymena"s ATR orthologue.	Caffeine	228-236	ATM serine/threonine kinase	Homo sapiens	202-205
19273591-6	2009	Epitasis analysis indicates that the mutation of SIT4 or TIP41, encoding a Tap42-interacting protein, abolishes the sensitivity of the ptc1 strain to rapamycin and caffeine.	Caffeine	164-172	Tap42p	Saccharomyces cerevisiae S288C	75-80
19273591-6	2009	Epitasis analysis indicates that the mutation of SIT4 or TIP41, encoding a Tap42-interacting protein, abolishes the sensitivity of the ptc1 strain to rapamycin and caffeine.	Caffeine	164-172	type 2C protein phosphatase PTC1	Saccharomyces cerevisiae S288C	135-139
19450128-2	2009	MATERIALS &amp; METHODS: CYP1A2 activity was determined by plasma paraxanthine:caffeine ratio (17X:137X) 4 h after the intake of a standardized cup of coffee in 146 Turkish healthy volunteers.	Caffeine	79-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
19262568-4	2009	This inhibition is dependent upon Mec1/Tel1 kinase activity, as HU-treated cells form Rad52 foci in the presence of the PI3 kinase inhibitor caffeine.	Caffeine	141-149	ATR serine/threonine kinase	Homo sapiens	34-38
19305423-7	2009	These effects were inhibited by caffeine, an ATM kinase inhibitor.	Caffeine	32-40	ATM serine/threonine kinase	Homo sapiens	45-48
19262568-4	2009	This inhibition is dependent upon Mec1/Tel1 kinase activity, as HU-treated cells form Rad52 foci in the presence of the PI3 kinase inhibitor caffeine.	Caffeine	141-149	ETS variant transcription factor 6	Homo sapiens	39-43
19262568-4	2009	This inhibition is dependent upon Mec1/Tel1 kinase activity, as HU-treated cells form Rad52 foci in the presence of the PI3 kinase inhibitor caffeine.	Caffeine	141-149	RAD52 homolog, DNA repair protein	Homo sapiens	86-91
19098271-6	2009	Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle.	Caffeine	180-188	CD226 molecule	Homo sapiens	13-19
19098271-6	2009	Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle.	Caffeine	180-188	killer cell lectin like receptor K1	Homo sapiens	24-29
19098271-6	2009	Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle.	Caffeine	180-188	ATM serine/threonine kinase	Homo sapiens	87-121
19098271-6	2009	Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle.	Caffeine	180-188	ATR serine/threonine kinase	Homo sapiens	127-130
19098271-6	2009	Drug-induced DNAM-1 and NKG2D ligand expression was abolished after treatment with the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) pharmacologic inhibitors caffeine and KU-55933, and was preferentially associated with senescent cells arrested in the G2 phase of the cell cycle.	Caffeine	180-188	ATR serine/threonine kinase	Homo sapiens	132-153
19336623-3	2009	Next, we determined the amplitudes of intracellular Ca(2+) concentration transients induced by electrical stimulation or caffeine, which represent, respectively, Ca(2+) release via the ryanodine receptor (RyR) or releasable Ca(2+) in the SR, in ventricular myocytes isolated from the three groups of rats.	Caffeine	121-129	ryanodine receptor 2	Rattus norvegicus	205-208
19218506-10	2009	Injection of 30 mg/kg caffeine decreased Temp, especially in KO mice, and hence in a manner unrelated to A(1)R or A(2A)R blockade.	Caffeine	22-30	RIKEN cDNA 2610528J11 gene	Mus musculus	41-45
19088180-7	2009	Caffeine exposure resulted in inhibition of hypoxia-induced HIF1alpha protein expression in embryos by 40%.	Caffeine	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	60-69
19082994-0	2009	Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?	Caffeine	68-76	N-acetyltransferase 2	Homo sapiens	15-41
19082994-1	2009	OBJECTIVES: Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites.	Caffeine	135-143	N-acetyltransferase 2	Homo sapiens	37-58
19082994-1	2009	OBJECTIVES: Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites.	Caffeine	135-143	N-acetyltransferase 2	Homo sapiens	60-64
19082994-6	2009	RESULTS: The NAT2 ratios were stable in the intervals 4-24 h after caffeine dosing.	Caffeine	67-75	N-acetyltransferase 2	Homo sapiens	13-17
19082994-11	2009	CONCLUSIONS: Any sampling interval at least 4 h after caffeine dosing is suitable for NAT2 and XO activity assessments.	Caffeine	54-62	N-acetyltransferase 2	Homo sapiens	86-90
19246397-7	2009	Caffeine-induced action potentials were also eliminated in Gr93a-mutant animals, while the flies displayed normal responses to other aversive compounds or to sugars.	Caffeine	0-8	Gustatory receptor 93a	Drosophila melanogaster	59-64
19298694-5	2009	KEY FINDINGS: Plasma aspartate aminotransferase and alanine aminotransferase levels were significantly increased after LPS/D-GalN-treatment, but were suppressed by pretreatment with caffeine (n = 5), nicotinic acid, non-substituted pyrazinoic acid or 5-methylpyrazinoic acid (n = 6, respectively) 12 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	182-190	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	21-47
19298694-5	2009	KEY FINDINGS: Plasma aspartate aminotransferase and alanine aminotransferase levels were significantly increased after LPS/D-GalN-treatment, but were suppressed by pretreatment with caffeine (n = 5), nicotinic acid, non-substituted pyrazinoic acid or 5-methylpyrazinoic acid (n = 6, respectively) 12 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	182-190	galanin and GMAP prepropeptide	Rattus norvegicus	125-129
19298694-5	2009	KEY FINDINGS: Plasma aspartate aminotransferase and alanine aminotransferase levels were significantly increased after LPS/D-GalN-treatment, but were suppressed by pretreatment with caffeine (n = 5), nicotinic acid, non-substituted pyrazinoic acid or 5-methylpyrazinoic acid (n = 6, respectively) 12 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	182-190	galanin and GMAP prepropeptide	Rattus norvegicus	314-318
19298694-7	2009	Only pretreatment with caffeine significantly suppressed the LPS/D-GalN induced elevation of plasma TNF-alpha levels 1 and 2 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	23-31	galanin and GMAP prepropeptide	Rattus norvegicus	67-71
19298694-7	2009	Only pretreatment with caffeine significantly suppressed the LPS/D-GalN induced elevation of plasma TNF-alpha levels 1 and 2 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	23-31	tumor necrosis factor	Rattus norvegicus	100-109
19298694-7	2009	Only pretreatment with caffeine significantly suppressed the LPS/D-GalN induced elevation of plasma TNF-alpha levels 1 and 2 h after LPS/D-GalN-treatment (P &lt; 0.01, respectively).	Caffeine	23-31	galanin and GMAP prepropeptide	Rattus norvegicus	139-143
19298694-8	2009	Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats.	Caffeine	18-26	galanin and GMAP prepropeptide	Rattus norvegicus	98-102
19298694-8	2009	Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats.	Caffeine	18-26	interleukin 10	Rattus norvegicus	131-136
19298694-8	2009	Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats.	Caffeine	18-26	interleukin 10	Rattus norvegicus	222-227
19298694-9	2009	CONCLUSIONS: The results suggest that caffeine, nicotinic acid, non-substituted pyrazinoic acid and 5-methylpyrazinoic acid can protect against LPS/D-GalN induced acute liver injury, which may be mediated by the reduction of TNF-alpha production and/or increasing IL-10 production.	Caffeine	38-46	galanin and GMAP prepropeptide	Rattus norvegicus	150-154
19298694-9	2009	CONCLUSIONS: The results suggest that caffeine, nicotinic acid, non-substituted pyrazinoic acid and 5-methylpyrazinoic acid can protect against LPS/D-GalN induced acute liver injury, which may be mediated by the reduction of TNF-alpha production and/or increasing IL-10 production.	Caffeine	38-46	tumor necrosis factor	Rattus norvegicus	225-234
19298694-9	2009	CONCLUSIONS: The results suggest that caffeine, nicotinic acid, non-substituted pyrazinoic acid and 5-methylpyrazinoic acid can protect against LPS/D-GalN induced acute liver injury, which may be mediated by the reduction of TNF-alpha production and/or increasing IL-10 production.	Caffeine	38-46	interleukin 10	Rattus norvegicus	264-269
19023563-10	2009	In conclusion, MCT1-mediated transport of (14)C-BT in Caco-2 cells is modulated by either acute or chronic exposure to some pharmacological agents and drugs of abuse (acetaldehyde, acetylsalicylic acid, indomethacin, caffeine, theophylline and the drugs of abuse tetrahydrocannabinol and MDMA).	Caffeine	217-225	solute carrier family 16 member 1	Homo sapiens	15-19
19246397-10	2009	Because Gr93a- and Gr66a-mutant animals exhibit the identical phenotypes and function in the same cells, we propose that they may be caffeine coreceptors.	Caffeine	133-141	Gustatory receptor 93a	Drosophila melanogaster	8-13
19246397-10	2009	Because Gr93a- and Gr66a-mutant animals exhibit the identical phenotypes and function in the same cells, we propose that they may be caffeine coreceptors.	Caffeine	133-141	Gustatory receptor 66a	Drosophila melanogaster	19-24
19005161-7	2009	In contrast, our whole animal and transcriptional studies indicate that hypoxia in combination with exercise enhanced the release of calcium from the sarcoplasmic reticulum via the ryanodine receptors triggered by caffeine, which increased the translocation of nuclear factor of activated T-cells into the nucleus to transcriptionally activate myoglobin expression.	Caffeine	214-222	myoglobin	Mus musculus	344-353
19153161-7	2009	Potentiation of the opening of the ryanodine receptor (RyR) by low concentrations of caffeine (100 microm) abolished alternans for a few pulses but the alternans then redeveloped once SR Ca(2+) content fell to the new threshold for wave propagation.	Caffeine	85-93	ryanodine receptor 2	Rattus norvegicus	35-53
19153161-7	2009	Potentiation of the opening of the ryanodine receptor (RyR) by low concentrations of caffeine (100 microm) abolished alternans for a few pulses but the alternans then redeveloped once SR Ca(2+) content fell to the new threshold for wave propagation.	Caffeine	85-93	ryanodine receptor 2	Rattus norvegicus	55-58
19002719-7	2009	Caffeine, nicotine, or both significantly decreased agrin-induced AChR clustering during short-term and long-term exposure.	Caffeine	0-8	agrin	Mus musculus	52-57
19296337-3	2009	Cells were pre-treated with caffeine for inhibiting ATM/ATR (ataxia-telangiectasia mutated protein/ATM and Rad-3-related protein) activation, wherever required.	Caffeine	28-36	ATM serine/threonine kinase	Homo sapiens	52-55
19296337-3	2009	Cells were pre-treated with caffeine for inhibiting ATM/ATR (ataxia-telangiectasia mutated protein/ATM and Rad-3-related protein) activation, wherever required.	Caffeine	28-36	ATR serine/threonine kinase	Homo sapiens	56-59
19296337-3	2009	Cells were pre-treated with caffeine for inhibiting ATM/ATR (ataxia-telangiectasia mutated protein/ATM and Rad-3-related protein) activation, wherever required.	Caffeine	28-36	ATM serine/threonine kinase	Homo sapiens	99-102
19116207-2	2009	In RINm5F insulinoma cells, caffeine, and 4-chloro-m-cresol (4CmC), agonists of RyR, stimulated Ca(2+) entry that was independent of store-operated Ca(2+) entry, and blocked by prior incubation with a concentration of ryanodine that inactivates RyR.	Caffeine	28-36	ryanodine receptor 2	Rattus norvegicus	80-83
19116207-2	2009	In RINm5F insulinoma cells, caffeine, and 4-chloro-m-cresol (4CmC), agonists of RyR, stimulated Ca(2+) entry that was independent of store-operated Ca(2+) entry, and blocked by prior incubation with a concentration of ryanodine that inactivates RyR.	Caffeine	28-36	ryanodine receptor 2	Rattus norvegicus	245-248
19220289-8	2009	Application of caffeine demonstrated that 50 nmol x L(-1) CaM reduced SR Ca(2+) content.	Caffeine	15-23	L1 cell adhesion molecule	Rattus norvegicus	52-61
19220289-10	2009	Similarly, in cardiac cells, CaM stimulates SR Ca(2+)-release and the use of caffeine suggests that this is a RyR2-mediated effect.	Caffeine	77-85	ryanodine receptor 2	Rattus norvegicus	110-114
19065152-3	2009	We report here that AtCAF1a and AtCAF1b, putative Arabidopsis homologs of the yeast CAF1 gene, partially complement the growth defect of the yeast caf1 mutant in the presence of caffeine or at high temperatures.	Caffeine	178-186	Polynucleotidyl transferase, ribonuclease H-like superfamily protein	Arabidopsis thaliana	20-27
19065152-3	2009	We report here that AtCAF1a and AtCAF1b, putative Arabidopsis homologs of the yeast CAF1 gene, partially complement the growth defect of the yeast caf1 mutant in the presence of caffeine or at high temperatures.	Caffeine	178-186	Polynucleotidyl transferase, ribonuclease H-like superfamily protein	Arabidopsis thaliana	32-39
19065152-3	2009	We report here that AtCAF1a and AtCAF1b, putative Arabidopsis homologs of the yeast CAF1 gene, partially complement the growth defect of the yeast caf1 mutant in the presence of caffeine or at high temperatures.	Caffeine	178-186	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	22-26
19065152-3	2009	We report here that AtCAF1a and AtCAF1b, putative Arabidopsis homologs of the yeast CAF1 gene, partially complement the growth defect of the yeast caf1 mutant in the presence of caffeine or at high temperatures.	Caffeine	178-186	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	147-151
19027757-5	2009	Chronic caffeine assumption sensitized GABAergic synapses to the presynaptic effect of cannabinoid CB1 receptor stimulation by exo- and endocannabinoids.	Caffeine	8-16	cannabinoid receptor 1	Homo sapiens	99-102
19027757-8	2009	Furthermore, although exposure to caffeine for only 24h did not produce measurable changes of the sensitivity of cannabinoid CB1 receptors, it was able to contrast the down-regulation of CB1 receptor-mediated responses after social defeat stress.	Caffeine	34-42	cannabinoid receptor 1	Homo sapiens	187-190
18948275-4	2009	METHODS AND RESULTS: The rate of Ca(2+) transport by PMCA, NCX, and SERCA2a was estimated from the rate constants of decay of electrically and caffeine-evoked Ca(2+) transients in left ventricular myocytes isolated 1 week, 1 month, and 3 months after MI.	Caffeine	143-151	solute carrier family 8 member A1	Rattus norvegicus	59-62
18663468-3	2009	Our results indicate that spontaneous local Ca2+ release and caffeine-induced global Ca2+ release are significantly reduced in embryonic RyR1-/- and adult RyR+/- cells.	Caffeine	61-69	ryanodine receptor 1, skeletal muscle	Mus musculus	137-141
18663468-3	2009	Our results indicate that spontaneous local Ca2+ release and caffeine-induced global Ca2+ release are significantly reduced in embryonic RyR1-/- and adult RyR+/- cells.	Caffeine	61-69	ryanodine receptor 1, skeletal muscle	Mus musculus	137-140
18797174-0	2008	Effects of cryopreservation on Ca2+ signals induced by membrane depolarization, caffeine, thapsigargin and progesterone in boar spermatozoa.	Caffeine	80-88	carbonic anhydrase 2	Homo sapiens	31-34
18820706-8	2009	In support of this, ectopic expression of this truncated cyclin B1 was not only sufficient to induce mitotic block and apoptosis but also enhanced mitotic catastrophe induced by ionizing radiation and caffeine.	Caffeine	201-209	cyclin B1	Homo sapiens	57-66
18620751-4	2009	Unlike triadin knockdown myotubes, junctin knockdown and junctin/triadin double knockdown myotubes also had reduced Ca2+ release induced by 400 microM 4-chloro-m-cresol, 10mM caffeine, 400 microM UTP, or 1 microM thapsigargin.	Caffeine	175-183	aspartate beta-hydroxylase	Homo sapiens	57-64
18954145-5	2009	The enantiomeric specificity is also demonstrated in intact HEK 293 cells expressing RyR1 where exposure to (-)-PCB 136 (100 nM; 12 h) sensitizes responses to caffeine, whereas (+)-PCB 136 does not.	Caffeine	159-167	ryanodine receptor 1	Homo sapiens	85-89
18954145-5	2009	The enantiomeric specificity is also demonstrated in intact HEK 293 cells expressing RyR1 where exposure to (-)-PCB 136 (100 nM; 12 h) sensitizes responses to caffeine, whereas (+)-PCB 136 does not.	Caffeine	159-167	pyruvate carboxylase	Homo sapiens	112-115
18704388-3	2009	METHODS: In two studies in healthy young Caucasians, NAT2 phenotyping was carried out using a caffeine metabolic ratio in urine 4-6 h postdose.	Caffeine	94-102	N-acetyltransferase 2	Homo sapiens	53-57
20300593-4	2009	[Ca(2+)](i) responses to caffeine, a ryanodine receptor (RyR) agonist, were decreased in -/- myotubes and absent in -/- myoblasts.	Caffeine	25-33	ryanodine receptor 1, skeletal muscle	Mus musculus	37-55
20300593-4	2009	[Ca(2+)](i) responses to caffeine, a ryanodine receptor (RyR) agonist, were decreased in -/- myotubes and absent in -/- myoblasts.	Caffeine	25-33	ryanodine receptor 1, skeletal muscle	Mus musculus	57-60
19581722-0	2009	Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer"s disease mice.	Caffeine	0-8	amyloid beta precursor protein	Homo sapiens	59-71
19581722-1	2009	We have recently shown that Alzheimer"s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression.	Caffeine	95-103	amyloid beta precursor protein	Homo sapiens	266-278
19581722-1	2009	We have recently shown that Alzheimer"s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression.	Caffeine	95-103	amyloid beta precursor protein	Homo sapiens	280-285
19581722-1	2009	We have recently shown that Alzheimer"s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression.	Caffeine	95-103	beta-secretase 1	Homo sapiens	337-342
19581722-1	2009	We have recently shown that Alzheimer"s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression.	Caffeine	95-103	presenilin 1	Homo sapiens	348-360
19581722-1	2009	We have recently shown that Alzheimer"s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-beta (Abeta) levels due to suppression of both beta-secretase (BACE1) and presenilin 1 (PS1)/gamma-secretase expression.	Caffeine	95-103	presenilin 1	Homo sapiens	362-365
19581722-5	2009	Mechanistically, evidence is provided that caffeine suppression of BACE1 involves the cRaf-1/NFkappaB pathway.	Caffeine	43-51	beta-site APP cleaving enzyme 1	Mus musculus	67-72
19581722-5	2009	Mechanistically, evidence is provided that caffeine suppression of BACE1 involves the cRaf-1/NFkappaB pathway.	Caffeine	43-51	v-raf-leukemia viral oncogene 1	Mus musculus	86-92
19581722-5	2009	Mechanistically, evidence is provided that caffeine suppression of BACE1 involves the cRaf-1/NFkappaB pathway.	Caffeine	43-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-101
19581722-7	2009	Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD.	Caffeine	164-172	amyloid beta (A4) precursor protein	Mus musculus	39-44
19581723-2	2009	Supportive of this premise, our previous studies have shown that moderate caffeine administration protects/restores cognitive function and suppresses brain amyloid-beta (Abeta) production in AD transgenic mice.	Caffeine	74-82	amyloid beta (A4) precursor protein	Mus musculus	170-175
19581723-3	2009	In the present study, we report that acute caffeine administration to both young adult and aged AD transgenic mice rapidly reduces Abeta levels in both brain interstitial fluid and plasma without affecting Abeta elimination.	Caffeine	43-51	amyloid beta (A4) precursor protein	Mus musculus	131-136
19581723-4	2009	Long-term oral caffeine treatment to aged AD mice provided not only sustained reductions in plasma Abeta, but also decreases in both soluble and deposited Abeta in hippocampus and cortex.	Caffeine	15-23	amyloid beta (A4) precursor protein	Mus musculus	99-104
19581723-4	2009	Long-term oral caffeine treatment to aged AD mice provided not only sustained reductions in plasma Abeta, but also decreases in both soluble and deposited Abeta in hippocampus and cortex.	Caffeine	15-23	amyloid beta (A4) precursor protein	Mus musculus	155-160
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	107-115	amyloid beta (A4) precursor protein	Mus musculus	62-67
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	107-115	amyloid beta (A4) precursor protein	Mus musculus	251-256
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	107-115	amyloid beta (A4) precursor protein	Mus musculus	251-256
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	206-214	amyloid beta (A4) precursor protein	Mus musculus	62-67
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	206-214	amyloid beta (A4) precursor protein	Mus musculus	251-256
19581723-8	2009	Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.	Caffeine	206-214	amyloid beta (A4) precursor protein	Mus musculus	251-256
19047957-0	2009	Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors.	Caffeine	0-8	tumor necrosis factor	Homo sapiens	19-28
19047957-6	2009	Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a &gt; or =2-fold increase in cAMP (p &lt; 0.05).	Caffeine	5-13	tumor necrosis factor	Homo sapiens	54-81
19047957-6	2009	Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a &gt; or =2-fold increase in cAMP (p &lt; 0.05).	Caffeine	5-13	tumor necrosis factor	Homo sapiens	83-92
19047957-6	2009	Only caffeine (50 microM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-alpha) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-alpha gene expression by 30 and 50%, respectively, in conjunction with a &gt; or =2-fold increase in cAMP (p &lt; 0.05).	Caffeine	5-13	tumor necrosis factor	Homo sapiens	154-163
19047957-9	2009	Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-alpha production by CBM.	Caffeine	31-39	tumor necrosis factor	Homo sapiens	117-126
18971392-5	2009	In C2C12 myotubes, caffeine, a sarcoplasmic reticulum calcium-releasing agent, had a biphasic effect on GLUT-4 expression and glucose uptake.	Caffeine	19-27	solute carrier family 2 member 4	Sus scrofa	104-110
18971392-6	2009	Low-concentration (1.25 to 2 mM) or short-term (4 h) caffeine treatment together with the AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), had an additive effect on GLUT-4 expression.	Caffeine	53-61	solute carrier family 2 member 4	Sus scrofa	196-202
18971392-7	2009	However, high-concentration (2.5 to 5 mM) or long-term (4 to 30 h) caffeine treatment decreased AMPK-induced GLUT-4 expression without affecting cell viability.	Caffeine	67-75	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	96-100
18971392-7	2009	However, high-concentration (2.5 to 5 mM) or long-term (4 to 30 h) caffeine treatment decreased AMPK-induced GLUT-4 expression without affecting cell viability.	Caffeine	67-75	solute carrier family 2 member 4	Sus scrofa	109-115
18971392-8	2009	The negative effect of caffeine on AICAR-induced GLUT-4 expression was reduced by dantrolene, which desensitizes the ryanodine receptor.	Caffeine	23-31	solute carrier family 2 member 4	Sus scrofa	49-55
19685112-9	2009	The half-maximal activation concentrations (EC(50)) of caffeine and 4CmC for HEK-293 cells transfected with the p.R2508C mutation were 1.86 +/- 0.23 mM and 73.14 +/- 19.44 microM, while those for wild-type RYR1 were 2.62 +/- 0.23 mM and 179.31 +/- 35.23 microM, respectively.	Caffeine	55-63	ryanodine receptor 1	Homo sapiens	206-210
19685112-10	2009	CONCLUSION: We demonstrated that the transfected RYR1 mutant was more sensitive to caffeine and 4CmC than wildtype RYR1.	Caffeine	83-91	ryanodine receptor 1	Homo sapiens	49-53
19125184-7	2009	An enhanced NCX function in FTG, as reflected by an accelerated relaxation of the caffeine-induced Ca2+ transient, is insufficient to maintain a normal diastolic Ca2+ during high rates of stimulation.	Caffeine	82-90	T cell leukemia, homeobox 2	Mus musculus	12-15
18957290-7	2008	Interestingly, the effect of caffeine and La(3+) but not nifedipine were diminished in the present of 2-APB.	Caffeine	29-37	arginyl aminopeptidase	Homo sapiens	104-107
18797174-5	2008	Caffeine elicited Ca2+ transients with some oscillations in the fresh spermatozoa, but not in the thawed spermatozoa.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	18-21
19074291-0	2008	Drosophila D1 dopamine receptor mediates caffeine-induced arousal.	Caffeine	41-49	Dopamine 1-like receptor 1	Drosophila melanogaster	11-31
19074291-5	2008	In WT flies, CAFF exposure leads to downregulation of dDA1 expression, whereas the transgenic overexpression of dDA1 leads to CAFF resistance.	Caffeine	126-130	Dopamine 1-like receptor 1	Drosophila melanogaster	112-116
19074291-4	2008	By measuring behavioral responses in mutant and transgenic flies exposed to different drug-feeding regimens, we show that CAFF-induced wakefulness requires the Drosophila D1 dopamine receptor (dDA1) in the mushroom bodies.	Caffeine	122-126	Dopamine 1-like receptor 1	Drosophila melanogaster	171-191
19074291-4	2008	By measuring behavioral responses in mutant and transgenic flies exposed to different drug-feeding regimens, we show that CAFF-induced wakefulness requires the Drosophila D1 dopamine receptor (dDA1) in the mushroom bodies.	Caffeine	122-126	Dopamine 1-like receptor 1	Drosophila melanogaster	193-197
19074291-5	2008	In WT flies, CAFF exposure leads to downregulation of dDA1 expression, whereas the transgenic overexpression of dDA1 leads to CAFF resistance.	Caffeine	13-17	Dopamine 1-like receptor 1	Drosophila melanogaster	54-58
18836030-10	2008	The data show that thrombin induces increases in intracellular calcium in PASMC and PAEC with a distinct CPA-, caffeine-, and ryanodine-insensitive release existing only in PAEC.	Caffeine	111-119	coagulation factor II, thrombin	Homo sapiens	19-27
18669599-7	2008	Caffeine blocked adenosine receptors and induced hepatic mPlrp2 and mClps expression in wild-type mice.	Caffeine	0-8	pancreatic lipase-related protein 2	Mus musculus	57-63
19088791-3	2008	They also exist despite clear evidence showing that caffeine causes acute postprandial hyperglycemia and lower whole-body insulin sensitivity.	Caffeine	52-60	insulin	Homo sapiens	122-129
18305461-0	2008	Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.	Caffeine	55-63	adenosine A2a receptor	Homo sapiens	20-27
18988737-0	2008	Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.	Caffeine	0-8	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	25-30
18988737-0	2008	Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.	Caffeine	0-8	transient receptor potential cation channel subfamily A member 1	Homo sapiens	61-66
18988737-2	2008	We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca(2+)(i) imaging and electrophysiological analyses.	Caffeine	17-25	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	42-73
18988737-2	2008	We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca(2+)(i) imaging and electrophysiological analyses.	Caffeine	17-25	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	75-80
18988737-3	2008	These responses to caffeine were confirmed in acutely dissociated dorsal root ganglion sensory neurons from WT mice, which are known to express TRPA1, but were not seen in neurons from TRPA1 KO mice.	Caffeine	19-27	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	144-149
18988737-6	2008	These results demonstrate that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting they mediate the perception of caffeine.	Caffeine	111-119	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	37-42
18988737-6	2008	These results demonstrate that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting they mediate the perception of caffeine.	Caffeine	180-188	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	37-42
18808450-8	2008	We found that caffeine blocked MPTP-induced decreases in numbers of tyrosine hydroxylase-positive dopaminergic neurons, increases in leakage of Evan"s blue dye and FITC-albumin in striatum but not in cerebral cortex or hippocampus, decreases in levels of the tight junction proteins occludin and ZO-1, and increases in reactive gliosis.	Caffeine	14-22	occludin	Mus musculus	283-291
18808450-8	2008	We found that caffeine blocked MPTP-induced decreases in numbers of tyrosine hydroxylase-positive dopaminergic neurons, increases in leakage of Evan"s blue dye and FITC-albumin in striatum but not in cerebral cortex or hippocampus, decreases in levels of the tight junction proteins occludin and ZO-1, and increases in reactive gliosis.	Caffeine	14-22	tight junction protein 1	Mus musculus	296-300
18949657-2	2008	In a reconstituted system, this enzyme showed a good catalytic activity towards caffeine, acetanilide, and methoxyresorufin, all known markers of mammalian CYP1A2.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
19004803-4	2008	Remarkably, inhibition of ATR signaling in primary human lung fibroblasts by treatment with caffeine, or with siRNA specifically targeting ATR, resulted in total inhibition of 6-4PP removal during S phase, whereas cells repaired normally during either G(0)/G(1) or G(2)/M.	Caffeine	92-100	ATR serine/threonine kinase	Homo sapiens	26-29
18486259-0	2008	Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways.	Caffeine	31-39	transforming growth factor, beta 1	Rattus norvegicus	49-57
18486259-0	2008	Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways.	Caffeine	31-39	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	131-140
18486259-0	2008	Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways.	Caffeine	31-39	SMAD family member 2	Rattus norvegicus	145-152
18486259-2	2008	METHODS: We investigated the pharmacological mechanisms involved in caffeine-dependent regulation of CTGF expression, an important modulator protein of fibrogenic TGF-beta, in rat hepatocytes using Western-blot, co-immunoprecipitations, reporter-gene-assays and ELISAs.	Caffeine	68-76	cellular communication network factor 2	Rattus norvegicus	101-105
18486259-2	2008	METHODS: We investigated the pharmacological mechanisms involved in caffeine-dependent regulation of CTGF expression, an important modulator protein of fibrogenic TGF-beta, in rat hepatocytes using Western-blot, co-immunoprecipitations, reporter-gene-assays and ELISAs.	Caffeine	68-76	transforming growth factor, beta 1	Rattus norvegicus	163-171
18486259-3	2008	RESULTS: It is demonstrated that caffeine, similar to 8-Br-cAMP, suppresses CTGF expression, decreases SMAD2 protein levels and inhibits SMAD1/3-phosphorylation.	Caffeine	33-41	cellular communication network factor 2	Rattus norvegicus	76-80
18486259-3	2008	RESULTS: It is demonstrated that caffeine, similar to 8-Br-cAMP, suppresses CTGF expression, decreases SMAD2 protein levels and inhibits SMAD1/3-phosphorylation.	Caffeine	33-41	SMAD family member 2	Rattus norvegicus	103-108
18486259-3	2008	RESULTS: It is demonstrated that caffeine, similar to 8-Br-cAMP, suppresses CTGF expression, decreases SMAD2 protein levels and inhibits SMAD1/3-phosphorylation.	Caffeine	33-41	SMAD family member 1	Rattus norvegicus	137-144
18486259-5	2008	Additionally, caffeine leads to an up-regulation of PPARgamma expression, that enhances the inhibitory effect of the natural PPARgamma agonist 15-PGJ(2) on CTGF expression by inducing a dissociation of the SMAD2/3-CBP/p300-transcriptional complex.	Caffeine	14-22	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	52-61
18486259-5	2008	Additionally, caffeine leads to an up-regulation of PPARgamma expression, that enhances the inhibitory effect of the natural PPARgamma agonist 15-PGJ(2) on CTGF expression by inducing a dissociation of the SMAD2/3-CBP/p300-transcriptional complex.	Caffeine	14-22	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	125-134
18486259-5	2008	Additionally, caffeine leads to an up-regulation of PPARgamma expression, that enhances the inhibitory effect of the natural PPARgamma agonist 15-PGJ(2) on CTGF expression by inducing a dissociation of the SMAD2/3-CBP/p300-transcriptional complex.	Caffeine	14-22	cellular communication network factor 2	Rattus norvegicus	156-160
18486259-5	2008	Additionally, caffeine leads to an up-regulation of PPARgamma expression, that enhances the inhibitory effect of the natural PPARgamma agonist 15-PGJ(2) on CTGF expression by inducing a dissociation of the SMAD2/3-CBP/p300-transcriptional complex.	Caffeine	14-22	SMAD family member 2	Rattus norvegicus	206-211
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	transforming growth factor, beta 1	Rattus norvegicus	59-67
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	cellular communication network factor 2	Rattus norvegicus	76-80
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	transforming growth factor, beta 1	Rattus norvegicus	144-152
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	SMAD family member 2	Rattus norvegicus	162-168
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	SMAD family member 3	Rattus norvegicus	184-189
18486259-6	2008	CONCLUSIONS: We show that caffeine strongly down-modulates TGF-beta-induced CTGF expression in hepatocytes by stimulation of degradation of the TGF-beta effector SMAD 2, inhibition of SMAD3 phosphorylation and up-regulation of the PPARgamma-receptor.	Caffeine	26-34	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	231-240
18305461-0	2008	Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.	Caffeine	55-63	dopamine receptor D2	Homo sapiens	32-36
18305461-4	2008	In this study, we examined associations between self-reported anxiogenic effects of caffeine and variation in the genes for A(2A) (ADORA2A) and DRD(2) (DRD2) receptors.	Caffeine	84-92	adenosine A2a receptor	Homo sapiens	131-138
18305461-4	2008	In this study, we examined associations between self-reported anxiogenic effects of caffeine and variation in the genes for A(2A) (ADORA2A) and DRD(2) (DRD2) receptors.	Caffeine	84-92	dopamine receptor D2	Homo sapiens	144-150
18305461-4	2008	In this study, we examined associations between self-reported anxiogenic effects of caffeine and variation in the genes for A(2A) (ADORA2A) and DRD(2) (DRD2) receptors.	Caffeine	84-92	dopamine receptor D2	Homo sapiens	152-156
18305461-7	2008	At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3"-flank), and DRD2 rs1110976 (intron 6).	Caffeine	22-30	adenosine A2a receptor	Homo sapiens	132-139
18305461-7	2008	At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3"-flank), and DRD2 rs1110976 (intron 6).	Caffeine	22-30	dopamine receptor D2	Homo sapiens	213-217
18305461-7	2008	At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3"-flank), and DRD2 rs1110976 (intron 6).	Caffeine	75-83	adenosine A2a receptor	Homo sapiens	132-139
18305461-7	2008	At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3"-flank), and DRD2 rs1110976 (intron 6).	Caffeine	75-83	dopamine receptor D2	Homo sapiens	213-217
18305461-8	2008	Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	90-97
18305461-8	2008	Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms.	Caffeine	0-8	dopamine receptor D2	Homo sapiens	102-106
18305461-10	2008	These findings provide support for an association between an ADORA2A polymorphism and self-reported anxiety after a moderate dose of caffeine.	Caffeine	133-141	adenosine A2a receptor	Homo sapiens	61-68
18305461-11	2008	It is likely that other ADORA2A and DRD2 polymorphisms also contribute to responses to caffeine.	Caffeine	87-95	adenosine A2a receptor	Homo sapiens	24-31
18305461-11	2008	It is likely that other ADORA2A and DRD2 polymorphisms also contribute to responses to caffeine.	Caffeine	87-95	dopamine receptor D2	Homo sapiens	36-40
18829471-5	2008	Complete rejection or tumor growth retardation was observed when A2AR has been genetically eliminated or antagonized with synthetic drug or with natural A2AR antagonist 1,3,7-trimethylxanthine (caffeine).	Caffeine	169-192	adenosine A2a receptor	Mus musculus	65-69
18684486-4	2008	Levels of acetaminophen and caffeine in STP effluents were very low compared to the influent concentrations.	Caffeine	28-36	thyroid hormone receptor interactor 10	Homo sapiens	40-43
18946034-5	2008	Here, we show that the phosphorylation of pol eta increased after UV irradiation, and that treatment with caffeine, siRNA against ATR, or an inhibitor of PKC (calphostin C), reduced the accumulation of pol eta at stalled replication forks after UV irradiation or treatment with cisplatin and gemcitabine.	Caffeine	106-114	ATR serine/threonine kinase	Homo sapiens	130-133
18706486-0	2008	Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription.	Caffeine	9-17	spectrin, alpha, non-erythrocytic 1	Rattus norvegicus	149-152
18706486-10	2008	The abolition of Fos protein expression evoked by hypoxia suggested that caffeine exposure may decrease the activity of O2-sensing peripheral chemoreceptor pathway.	Caffeine	73-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-20
19230144-5	2008	When these fibres were exposed to caffeine to directly activate RyR1, regions with re-sealed t-tubules exhibited greater sensitivity to submaximal (2-5 mM) levels of caffeine (n = 8), while the response to a supramaximal SR Ca2+ release stimulus was uniform (n = 8, p &lt; 0.05).	Caffeine	34-42	ryanodine receptor 1	Rattus norvegicus	64-68
19211970-0	2008	Caffeine as a marker substrate for testing cytochrome P450 activity in human and rat.	Caffeine	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58
19211970-1	2008	The current knowledge on the involvement of cytochrome P450 (P450, CYP) isoforms in the metabolism of caffeine in rat and human liver is reviewed.	Caffeine	102-110	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	55-59
19211970-1	2008	The current knowledge on the involvement of cytochrome P450 (P450, CYP) isoforms in the metabolism of caffeine in rat and human liver is reviewed.	Caffeine	102-110	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-65
19211970-1	2008	The current knowledge on the involvement of cytochrome P450 (P450, CYP) isoforms in the metabolism of caffeine in rat and human liver is reviewed.	Caffeine	102-110	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	67-70
19211970-3	2008	Finally, we discuss the P450-mediated metabolism of caffeine in relation to coffee addiction and drug interactions.	Caffeine	52-60	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	24-28
19211970-4	2008	Due to its safety, favorable pharmacokinetic properties, and P450 isoform-selective metabolism, caffeine has great potential as a metabolic marker substance in both humans and rats, and as a more universal metabolic tool in the latter species.	Caffeine	96-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-65
19211970-5	2008	However, the qualitative and relative quantitative contribution of P450 isoforms to the metabolism of caffeine is species- and concentration-dependent.	Caffeine	102-110	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	67-71
19211970-8	2008	Caffeine may be applied as a marker substance for assessing the activity of CYP1A2 in human and rat liver, but by using different reactions: 3-N-demethylation in humans and C-8-hydroxylation in rats.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
19211970-11	2008	Caffeine pharmacokinetics may be changed by drugs affecting the activity of CYP1A2 (human and rat) or CYP2C (rat), e.g. via autoinduction or by treatment with certain antidepressants or neuroleptics.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
19211970-12	2008	Therefore, patients taking caffeine-containing medicine or coffee drinkers taking drugs that interact with CYP1A2 may require proper dosage adjustments upon caffeine ingestion and cessation.	Caffeine	27-35	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
19211970-12	2008	Therefore, patients taking caffeine-containing medicine or coffee drinkers taking drugs that interact with CYP1A2 may require proper dosage adjustments upon caffeine ingestion and cessation.	Caffeine	157-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
18759349-5	2008	We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551).	Caffeine	133-141	adenosine A2a receptor	Homo sapiens	79-86
18829471-5	2008	Complete rejection or tumor growth retardation was observed when A2AR has been genetically eliminated or antagonized with synthetic drug or with natural A2AR antagonist 1,3,7-trimethylxanthine (caffeine).	Caffeine	169-192	adenosine A2a receptor	Mus musculus	153-157
18829471-5	2008	Complete rejection or tumor growth retardation was observed when A2AR has been genetically eliminated or antagonized with synthetic drug or with natural A2AR antagonist 1,3,7-trimethylxanthine (caffeine).	Caffeine	194-202	adenosine A2a receptor	Mus musculus	65-69
18829471-5	2008	Complete rejection or tumor growth retardation was observed when A2AR has been genetically eliminated or antagonized with synthetic drug or with natural A2AR antagonist 1,3,7-trimethylxanthine (caffeine).	Caffeine	194-202	adenosine A2a receptor	Mus musculus	153-157
19230144-5	2008	When these fibres were exposed to caffeine to directly activate RyR1, regions with re-sealed t-tubules exhibited greater sensitivity to submaximal (2-5 mM) levels of caffeine (n = 8), while the response to a supramaximal SR Ca2+ release stimulus was uniform (n = 8, p &lt; 0.05).	Caffeine	166-174	ryanodine receptor 1	Rattus norvegicus	64-68
18946183-0	2008	The effects of BADGE and caffeine on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis.	Caffeine	25-33	adiponectin, C1Q and collagen domain containing	Mus musculus	65-76
18946183-3	2008	In high fat diet (HFD)-induced obese mice, we analyzed the time-course of changes in the expression of adiponectin and lipid oxidative enzymes induced by treatment with bisphenol A diglycidyl ether (BADGE) or caffeine for 8 weeks, and investigated whether the changes of adiponectin and lipid oxidative enzymes expression correlated with reduced adiposity or steatosis after 8 weeks of treatment.	Caffeine	209-217	adiponectin, C1Q and collagen domain containing	Mus musculus	103-114
18946183-6	2008	These results indicate that the expression of adiponectin and lipid oxidative enzymes in the early stages of BADGE or caffeine treatment correlated well with the long-term anti-obesity effects.	Caffeine	118-126	adiponectin, C1Q and collagen domain containing	Mus musculus	46-57
18518861-0	2008	Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	91-109
18518861-1	2008	Caffeine has long been used as a pharmacological probe for studying RyR (ryanodine receptor)-mediated Ca(2+) release and cardiac arrhythmias.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	68-71
18518861-1	2008	Caffeine has long been used as a pharmacological probe for studying RyR (ryanodine receptor)-mediated Ca(2+) release and cardiac arrhythmias.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	73-91
18518861-4	2008	We found that HEK-293 cells (human embryonic kidney cells) expressing RyR2 displayed partial or "quantal" Ca(2+) release in response to repetitive additions of submaximal concentrations of caffeine.	Caffeine	189-197	ryanodine receptor 2	Homo sapiens	70-74
18518861-10	2008	Collectively, our results demonstrate that caffeine triggers Ca(2+) release by reducing the threshold for luminal Ca(2+) activation of RyR2, and suggest that disease-linked RyR2 mutations and RyR2-interacting pro-arrhythmic agents may share the same arrhythmogenic mechanism.	Caffeine	43-51	ryanodine receptor 2	Homo sapiens	135-139
18518861-10	2008	Collectively, our results demonstrate that caffeine triggers Ca(2+) release by reducing the threshold for luminal Ca(2+) activation of RyR2, and suggest that disease-linked RyR2 mutations and RyR2-interacting pro-arrhythmic agents may share the same arrhythmogenic mechanism.	Caffeine	43-51	ryanodine receptor 2	Homo sapiens	173-177
18518861-10	2008	Collectively, our results demonstrate that caffeine triggers Ca(2+) release by reducing the threshold for luminal Ca(2+) activation of RyR2, and suggest that disease-linked RyR2 mutations and RyR2-interacting pro-arrhythmic agents may share the same arrhythmogenic mechanism.	Caffeine	43-51	ryanodine receptor 2	Homo sapiens	173-177
18673075-3	2008	Caffeine (an inhibitor of Myt1/Wee1 activity) can increase MPF and MAPK activities in ovine oocytes; however, the effects of caffeine treatment on the activation, nuclear configuration and developmental potential of ovine SC nuclear transfer (SCNT) embryos were unknown.	Caffeine	0-8	myelin transcription factor 1	Homo sapiens	26-30
18673075-3	2008	Caffeine (an inhibitor of Myt1/Wee1 activity) can increase MPF and MAPK activities in ovine oocytes; however, the effects of caffeine treatment on the activation, nuclear configuration and developmental potential of ovine SC nuclear transfer (SCNT) embryos were unknown.	Caffeine	0-8	WEE1 G2 checkpoint kinase	Homo sapiens	31-35
18583456-3	2008	Using mass spectroscopy, we found that Cox7c, a nuclear-encoded subunit of the mitochondrial enzyme cytochrome oxidase, is up-regulated in the striatum of male but not female mice after receiving a single dose of caffeine.	Caffeine	213-221	cytochrome c oxidase subunit 7C	Mus musculus	39-44
20443832-7	2008	In addition, re-cultured fluorescence-activated cell sorting (FACS)-purified BMP-2/FGF-2-treated mBMSCs revealed robust calcium transients in response to electrical field stimulation which were inhibited by the L-type calcium channel (LTCC) inhibitor, nifedipine, and displayed caffeine-sensitive intracellular calcium stores.	Caffeine	278-286	bone morphogenetic protein 2	Rattus norvegicus	77-82
20443832-7	2008	In addition, re-cultured fluorescence-activated cell sorting (FACS)-purified BMP-2/FGF-2-treated mBMSCs revealed robust calcium transients in response to electrical field stimulation which were inhibited by the L-type calcium channel (LTCC) inhibitor, nifedipine, and displayed caffeine-sensitive intracellular calcium stores.	Caffeine	278-286	fibroblast growth factor 2	Rattus norvegicus	83-88
18573860-10	2008	However, caffeine, melatonin, 9-cis-retinal, and estradiol, which are substrate for human CYP1A2, are not good substrates for dog CYP1A2.	Caffeine	9-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	90-96
18583456-4	2008	The expression of two other Cox subunits, Cox1 and Cox4, was also stimulated by caffeine in a male-specific fashion.	Caffeine	80-88	coproporphyrinogen oxidase	Rattus norvegicus	28-31
18583456-4	2008	The expression of two other Cox subunits, Cox1 and Cox4, was also stimulated by caffeine in a male-specific fashion.	Caffeine	80-88	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	42-46
18583456-4	2008	The expression of two other Cox subunits, Cox1 and Cox4, was also stimulated by caffeine in a male-specific fashion.	Caffeine	80-88	cytochrome c oxidase subunit 4i1	Rattus norvegicus	51-55
18583456-5	2008	This up-regulation of Cox subunits by caffeine was accompanied by an increase in Cox enzyme activity in the male striatum.	Caffeine	38-46	coproporphyrinogen oxidase	Rattus norvegicus	22-25
18583456-5	2008	This up-regulation of Cox subunits by caffeine was accompanied by an increase in Cox enzyme activity in the male striatum.	Caffeine	38-46	coproporphyrinogen oxidase	Rattus norvegicus	81-84
18583456-7	2008	Caffeine also increased Cox activity in PC-12 cells.	Caffeine	0-8	coproporphyrinogen oxidase	Rattus norvegicus	24-27
18583456-8	2008	In contrast, small interfering RNA (siRNA) knockdown of Cox7c expression in PC-12 cells blunted Cox activity, and this was counteracted by caffeine treatment.	Caffeine	139-147	cytochrome c oxidase subunit 7C	Rattus norvegicus	56-61
18583456-8	2008	In contrast, small interfering RNA (siRNA) knockdown of Cox7c expression in PC-12 cells blunted Cox activity, and this was counteracted by caffeine treatment.	Caffeine	139-147	coproporphyrinogen oxidase	Rattus norvegicus	56-59
18620014-0	2008	Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus.	Caffeine	0-8	brain derived neurotrophic factor	Mus musculus	86-90
18583456-9	2008	Caffeine was also found to increase Cox7c mRNA expression in the striatum and in PC-12 cells.	Caffeine	0-8	cytochrome c oxidase subunit 7C	Rattus norvegicus	36-41
18620014-0	2008	Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus.	Caffeine	0-8	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	95-99
18620014-9	2008	Western blotting analysis of hippocampus from caffeine-treated mice revealed an increase in BDNF and TrkB immunocontent, compared to their saline-matched controls.	Caffeine	46-54	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	101-105
18583456-11	2008	Overall, these findings indicate that cytochrome oxidase is a metabolic target of caffeine and that stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in PD.	Caffeine	131-139	coproporphyrinogen oxidase	Rattus norvegicus	115-118
18620014-11	2008	Our results suggest that acute treatment with caffeine improves recognition memory, and this effect may be related to an increase of the BDNF and TrkB immunocontent in the hippocampus.	Caffeine	46-54	brain derived neurotrophic factor	Mus musculus	137-141
18620014-11	2008	Our results suggest that acute treatment with caffeine improves recognition memory, and this effect may be related to an increase of the BDNF and TrkB immunocontent in the hippocampus.	Caffeine	46-54	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	146-150
18620014-3	2008	In addition, it was analyzed the effects of caffeine on brain derived neurotrophic factor (BDNF) and its receptor, TrkB, immunocontent to try to establish a connection between the behavioral finding and BDNF, one of the neurotrophins strictly involved in memory and learning process.	Caffeine	44-52	brain derived neurotrophic factor	Mus musculus	56-89
18620014-3	2008	In addition, it was analyzed the effects of caffeine on brain derived neurotrophic factor (BDNF) and its receptor, TrkB, immunocontent to try to establish a connection between the behavioral finding and BDNF, one of the neurotrophins strictly involved in memory and learning process.	Caffeine	44-52	brain derived neurotrophic factor	Mus musculus	91-95
18583456-11	2008	Overall, these findings indicate that cytochrome oxidase is a metabolic target of caffeine and that stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in PD.	Caffeine	131-139	adenosine A2a receptor	Rattus norvegicus	156-160
18620014-9	2008	Western blotting analysis of hippocampus from caffeine-treated mice revealed an increase in BDNF and TrkB immunocontent, compared to their saline-matched controls.	Caffeine	46-54	brain derived neurotrophic factor	Mus musculus	92-96
18583456-11	2008	Overall, these findings indicate that cytochrome oxidase is a metabolic target of caffeine and that stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in PD.	Caffeine	131-139	coproporphyrinogen oxidase	Rattus norvegicus	115-118
18583456-11	2008	Overall, these findings indicate that cytochrome oxidase is a metabolic target of caffeine and that stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in PD.	Caffeine	131-139	adenosine A2a receptor	Rattus norvegicus	156-160
18691092-5	2008	Caffeine has also been reported to inhibit ATM and ATR kinases which leads to the disruption of multiple DNA damage-responsive cell cycle checkpoints and greatly sensitizes tumor cells to antitumor agents which induce genotoxic stress.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	43-46
18619574-4	2008	At a higher caffeine concentration, the contribution of CYP1A2 to this reaction decreases in favour of CYP2C8/9.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62
18619574-4	2008	At a higher caffeine concentration, the contribution of CYP1A2 to this reaction decreases in favour of CYP2C8/9.	Caffeine	12-20	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	103-109
18619574-5	2008	The obtained data show for the first time the contribution of CYP2C isoforms to the metabolism of caffeine in human liver and suggest that apart from 3-N-demethylation, 1-N-demethylation may also be used for testing CYP1A2 activity.	Caffeine	98-106	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	216-222
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	55-63	mitotic arrest deficient 2 like 1	Homo sapiens	0-25
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	55-63	mitotic arrest deficient 2 like 1	Homo sapiens	27-31
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	55-63	mitotic arrest deficient 2 like 1	Homo sapiens	182-186
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	111-119	mitotic arrest deficient 2 like 1	Homo sapiens	0-25
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	111-119	mitotic arrest deficient 2 like 1	Homo sapiens	27-31
18754864-6	2008	Mitoticarrest deficient 2 (MAD2) depletion rescued the caffeine-induced delay of mitotic exit, indicating that caffeine-induced prolongation of mitosis was caused by activation of a MAD2-dependent spindle checkpoint.	Caffeine	111-119	mitotic arrest deficient 2 like 1	Homo sapiens	182-186
18469863-7	2008	The absence of ATM impaired apoptosis induced by E2F3a and treating K5 E2F3a transgenic mice with caffeine, an inhibitor of ATM and Rad3-related (ATR), promoted skin tumor development.	Caffeine	98-106	E2F transcription factor 3	Mus musculus	71-76
18469863-7	2008	The absence of ATM impaired apoptosis induced by E2F3a and treating K5 E2F3a transgenic mice with caffeine, an inhibitor of ATM and Rad3-related (ATR), promoted skin tumor development.	Caffeine	98-106	ataxia telangiectasia mutated	Mus musculus	124-127
18469863-7	2008	The absence of ATM impaired apoptosis induced by E2F3a and treating K5 E2F3a transgenic mice with caffeine, an inhibitor of ATM and Rad3-related (ATR), promoted skin tumor development.	Caffeine	98-106	ataxia telangiectasia and Rad3 related	Mus musculus	146-149
18390622-7	2008	Caffeine microperfusion of one end of a guinea pig or rat myocyte diffusively empties the whole SR at a rate indicating D(CaSR) is 8-9 microm(2)/s, up to tenfold lower than previous estimates.	Caffeine	0-8	calcium-sensing receptor	Rattus norvegicus	122-126
18562097-6	2008	Intraplantar administration of caffeine also reversed the effect of intraplantar amitriptyline in A1R +/+, but not in -/- or +/- mice.	Caffeine	31-39	adenosine A1 receptor	Mus musculus	98-101
18557781-8	2008	Polyamines, crowding agents, biotin and caffeine affected the activity and specificity of Fpg or OGG1 only marginally.	Caffeine	40-48	8-oxoguanine DNA glycosylase	Homo sapiens	97-101
18555802-7	2008	CCK-elicited Ca(2+) signals were inhibited reversibly by caffeine (5-20 mmol/L), indicating involvement of intracellular inositol trisphosphate receptor Ca(2+) release channels.	Caffeine	57-65	cholecystokinin	Homo sapiens	0-3
18511169-6	2008	Specific ATM inhibitor, caffeine, significantly decreased KTA-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	24-32	ATM serine/threonine kinase	Homo sapiens	9-12
18547548-6	2008	Cell death, measured by Fluoro-jade B and activated caspase-3, was significantly increased at 12 and 24 hour post-caffeine injection (P &lt; 0.05) in the cortex, caudate, nucleus accumbens, hypothalamus, hippocampus and superior colliculus.	Caffeine	114-122	caspase 3	Homo sapiens	52-61
18511169-6	2008	Specific ATM inhibitor, caffeine, significantly decreased KTA-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	24-32	tumor protein p53	Homo sapiens	120-123
18511169-6	2008	Specific ATM inhibitor, caffeine, significantly decreased KTA-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2.	Caffeine	24-32	checkpoint kinase 2	Homo sapiens	139-143
18499087-9	2008	On the other hand, caffeine, an agonist of the ryanodine receptor, caused a similar subcellular site-dependent changes in [Ca(2+)](i), thus mimicking the BNP effect.	Caffeine	19-27	natriuretic peptide B	Rattus norvegicus	154-157
18247328-9	2008	Moreover, caffeine, a known ATM/ATR kinase inhibitor, relieved the phosphorylation of cdc2 (Tyr-15) by hydroxyurea, but not that by lithium.	Caffeine	10-18	ATM serine/threonine kinase	Homo sapiens	28-31
18247328-9	2008	Moreover, caffeine, a known ATM/ATR kinase inhibitor, relieved the phosphorylation of cdc2 (Tyr-15) by hydroxyurea, but not that by lithium.	Caffeine	10-18	cyclin dependent kinase 1	Homo sapiens	86-90
18446524-8	2008	These results suggest that caffeine stimulates ryanodine receptor (RyR-2) and facilitates a Ca2+-signal transducing system from ER to mitochondria, and then, the signal appears to accelerate the ATP synthesis in mitochondria.	Caffeine	27-35	ryanodine receptor 2	Homo sapiens	67-72
18513215-5	2008	Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan.	Caffeine	72-80	protein kinase RIM15	Saccharomyces cerevisiae S288C	90-95
18513215-5	2008	Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan.	Caffeine	72-80	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	107-111
18436387-0	2008	Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice.	Caffeine	0-8	brain derived neurotrophic factor	Mus musculus	72-105
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	tumor protein p53	Homo sapiens	14-17
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	ATM serine/threonine kinase	Homo sapiens	79-82
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-153
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-158
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	159-163
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	arylacetamide deacetylase	Homo sapiens	195-198
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	215-218
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-163
18223691-9	2008	Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either the specific ATM inhibitor KU-5593 or caffeine abrogated p21(WAF1/CIP1) upregulation, indicating that DAC upregulation of p21(WAF1/CIP1) was p53- and ATM-dependent in leukemia cells.	Caffeine	131-139	tumor protein p53	Homo sapiens	234-237
18436387-0	2008	Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice.	Caffeine	0-8	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	136-140
18436387-8	2008	Caffeine also counteracted the age-related increase in BDNF and TrkB immunocontent.	Caffeine	0-8	brain derived neurotrophic factor	Mus musculus	55-59
18436387-8	2008	Caffeine also counteracted the age-related increase in BDNF and TrkB immunocontent.	Caffeine	0-8	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	64-68
18326664-5	2008	Surprisingly, when both substitutions were introduced in the same RyR2 subunit (RyR2-G1885E/G1886S), the store-overload-induced calcium release activity was nearly completely abolished, although the Ca(2+) loading of the intracellular stores was markedly enhanced, and the channel still displayed substantial Ca(2+) release on stimulation by 5 mM caffeine.	Caffeine	347-355	ryanodine receptor 2	Homo sapiens	66-70
18424641-5	2008	But SR Ca2+ content measured by caffeine-induced [Ca2+]i (C[Ca2+]i) transient was decreased 8.41 +/- 0.92% in response to apelin (n = 14, P &lt; 0.05).	Caffeine	32-40	apelin	Rattus norvegicus	122-128
18346049-0	2008	Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.	Caffeine	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	76-79
18346049-0	2008	Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.	Caffeine	0-8	mitogen-activated protein kinase 1	Homo sapiens	80-83
18346049-0	2008	Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.	Caffeine	0-8	epidermal growth factor receptor	Homo sapiens	84-88
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	mitogen-activated protein kinase kinase 7	Homo sapiens	77-116
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	mitogen-activated protein kinase kinase 7	Homo sapiens	118-121
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	mitogen-activated protein kinase 1	Homo sapiens	95-98
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	epidermal growth factor receptor	Homo sapiens	224-256
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	epidermal growth factor receptor	Homo sapiens	258-262
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	mitogen-activated protein kinase kinase 7	Homo sapiens	278-281
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	mitogen-activated protein kinase 1	Homo sapiens	162-165
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	40-48	epidermal growth factor receptor	Homo sapiens	286-290
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	mitogen-activated protein kinase kinase 7	Homo sapiens	77-116
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	mitogen-activated protein kinase kinase 7	Homo sapiens	118-121
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	mitogen-activated protein kinase 1	Homo sapiens	95-98
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	epidermal growth factor receptor	Homo sapiens	224-256
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	epidermal growth factor receptor	Homo sapiens	258-262
18346049-4	2008	We revealed a novel signalling axis for caffeine involving activation of the mitogen-activated ERK-regulating kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway that resulted in the downstream up-regulation of epidermal growth factor receptor (EGFR), although the MEK/ERK/EGFR signalling pathway was not involved in the growth inhibitory effect of caffeine.	Caffeine	362-370	mitogen-activated protein kinase 1	Homo sapiens	162-165
18326664-5	2008	Surprisingly, when both substitutions were introduced in the same RyR2 subunit (RyR2-G1885E/G1886S), the store-overload-induced calcium release activity was nearly completely abolished, although the Ca(2+) loading of the intracellular stores was markedly enhanced, and the channel still displayed substantial Ca(2+) release on stimulation by 5 mM caffeine.	Caffeine	347-355	ryanodine receptor 2	Homo sapiens	80-84
18440285-3	2008	Here, we further investigated the effect of cell confluence on UV-induced apoptosis in normal and NER-deficient (XP-A and XP-C) cells, as well as the effects of treatments with the ATM/ATR inhibitor caffeine, and the patterns of p53 activation.	Caffeine	199-207	ATM serine/threonine kinase	Homo sapiens	181-184
17950843-6	2008	Single colonic myocytes were voltage clamped in the whole cell configuration and cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) increases evoked by the RyR activator caffeine.	Caffeine	166-174	ryanodine receptor 2	Homo sapiens	152-155
18440285-3	2008	Here, we further investigated the effect of cell confluence on UV-induced apoptosis in normal and NER-deficient (XP-A and XP-C) cells, as well as the effects of treatments with the ATM/ATR inhibitor caffeine, and the patterns of p53 activation.	Caffeine	199-207	ATR serine/threonine kinase	Homo sapiens	185-188
18440285-5	2008	Caffeine increased apoptosis levels and inhibited p53 activation in proliferating cells, suggesting a protective role for p53.	Caffeine	0-8	tumor protein p53	Homo sapiens	50-53
18440285-5	2008	Caffeine increased apoptosis levels and inhibited p53 activation in proliferating cells, suggesting a protective role for p53.	Caffeine	0-8	tumor protein p53	Homo sapiens	122-125
18649015-1	2008	A recent study by Gressner and colleagues suggested caffeine may block CCN2 expression in hepatic cells.	Caffeine	52-60	cellular communication network factor 2	Homo sapiens	71-75
18715882-3	2008	CYP2A6 phenotype was determined by the urinary ratio 17U:17X in the interval of 4-5 h after caffeine intake in 179 healthy white Spaniards (102 women and 76 men).	Caffeine	92-100	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
18395996-0	2008	Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.	Caffeine	0-8	Cytochrome P450-6a2	Drosophila melanogaster	22-28
18395996-0	2008	Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.	Caffeine	0-8	Cytochrome P450-6a8	Drosophila melanogaster	33-39
18395996-0	2008	Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.	Caffeine	0-8	Jun-related antigen	Drosophila melanogaster	98-103
18395996-2	2008	We reported earlier that the promoters of Drosophila Cyp6a2 and Cyp6a8 genes are induced by caffeine.	Caffeine	92-100	Cytochrome P450-6a2	Drosophila melanogaster	53-59
18395996-2	2008	We reported earlier that the promoters of Drosophila Cyp6a2 and Cyp6a8 genes are induced by caffeine.	Caffeine	92-100	Cytochrome P450-6a8	Drosophila melanogaster	64-70
18395996-3	2008	Since caffeine antagonizes adenosine receptor (AdoR) and inhibits cAMP phosphodiesterase (PDE), we used luciferase reporter gene to examine whether in SL-2 cells and adult Drosophila, induction of the two Cyp6 genes is mediated via AdoR and/or PDE pathway.	Caffeine	6-14	Adenosine receptor	Drosophila melanogaster	27-45
18395996-3	2008	Since caffeine antagonizes adenosine receptor (AdoR) and inhibits cAMP phosphodiesterase (PDE), we used luciferase reporter gene to examine whether in SL-2 cells and adult Drosophila, induction of the two Cyp6 genes is mediated via AdoR and/or PDE pathway.	Caffeine	6-14	Adenosine receptor	Drosophila melanogaster	47-51
18395996-3	2008	Since caffeine antagonizes adenosine receptor (AdoR) and inhibits cAMP phosphodiesterase (PDE), we used luciferase reporter gene to examine whether in SL-2 cells and adult Drosophila, induction of the two Cyp6 genes is mediated via AdoR and/or PDE pathway.	Caffeine	6-14	Adenosine receptor	Drosophila melanogaster	232-236
18395996-11	2008	Interestingly, caffeine treatment decreased the D-JUN protein level in SL-2 cells as well as in adult flies.	Caffeine	15-23	Jun-related antigen	Drosophila melanogaster	48-53
18395996-12	2008	These results suggest that D-jun acts as a negative regulator, and caffeine induction of Cyp6a8 and Cyp6a2 genes is mediated by the upregulation of cAMP pathway and downregulation of the D-JUN protein level.	Caffeine	67-75	Cytochrome P450-6a8	Drosophila melanogaster	89-95
18395996-12	2008	These results suggest that D-jun acts as a negative regulator, and caffeine induction of Cyp6a8 and Cyp6a2 genes is mediated by the upregulation of cAMP pathway and downregulation of the D-JUN protein level.	Caffeine	67-75	Cytochrome P450-6a2	Drosophila melanogaster	100-106
18395996-12	2008	These results suggest that D-jun acts as a negative regulator, and caffeine induction of Cyp6a8 and Cyp6a2 genes is mediated by the upregulation of cAMP pathway and downregulation of the D-JUN protein level.	Caffeine	67-75	Jun-related antigen	Drosophila melanogaster	187-192
18406528-5	2008	RyR-mediated CICR was stimulated using the well-characterized RyR activator, caffeine.	Caffeine	77-85	ryanodine receptor 1	Homo sapiens	0-3
18406528-5	2008	RyR-mediated CICR was stimulated using the well-characterized RyR activator, caffeine.	Caffeine	77-85	ryanodine receptor 1	Homo sapiens	62-65
18406528-7	2008	Treatment with LEV (33 microM) prior to stimulation of RyR-mediated CICR by caffeine led to a 61% decrease in the caffeine induced peak height of [Ca2+]i when compared to the control.	Caffeine	76-84	ryanodine receptor 1	Homo sapiens	55-58
18359892-3	2008	Caffeine (10 mg.kg(-1).day(-1) subcutaneous) was administered daily to pregnant CD-1 mice from embryonic days (EDs) 9.5 to 18.5 of a 21-day gestation.	Caffeine	0-8	CD1 antigen complex	Mus musculus	80-84
18359892-10	2008	Maternal treatment with the adenosine A(2A) receptor inhibitor reproduced the embryonic hemodynamic effects of maternal caffeine exposure.	Caffeine	120-128	adenosine A2a receptor	Mus musculus	28-52
18359892-12	2008	Results suggest that modest maternal caffeine exposure has adverse effects on developing embryonic CV function and growth, possibly mediated via adenosine A(2A) receptor blockade.	Caffeine	37-45	adenosine A2a receptor	Mus musculus	145-169
18374908-0	2008	Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson"s disease phenotype in mouse.	Caffeine	13-21	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	93-126
18374908-6	2008	The study was therefore undertaken to investigate the effect of nicotine and caffeine on the expression and activity of toxicant responsive genes, i.e., CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 in the striatum of control and MPTP-induced PD phenotype in mouse.	Caffeine	77-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	153-159
18374908-6	2008	The study was therefore undertaken to investigate the effect of nicotine and caffeine on the expression and activity of toxicant responsive genes, i.e., CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 in the striatum of control and MPTP-induced PD phenotype in mouse.	Caffeine	77-85	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	161-167
18374908-6	2008	The study was therefore undertaken to investigate the effect of nicotine and caffeine on the expression and activity of toxicant responsive genes, i.e., CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 in the striatum of control and MPTP-induced PD phenotype in mouse.	Caffeine	77-85	glutathione S-transferase, alpha 4	Mus musculus	185-192
18374908-6	2008	The study was therefore undertaken to investigate the effect of nicotine and caffeine on the expression and activity of toxicant responsive genes, i.e., CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 in the striatum of control and MPTP-induced PD phenotype in mouse.	Caffeine	77-85	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	197-203
18258404-0	2008	Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate rats.	Caffeine	9-17	acetylcholinesterase	Rattus norvegicus	33-53
18258404-8	2008	However, caffeine promoted an increase of acetylcholinesterase activity (42%) without modifications on the level of acetylcholinesterase mRNA transcripts in 21-day-old rats.	Caffeine	9-17	acetylcholinesterase	Rattus norvegicus	42-62
18469247-1	2008	BACKGROUND: The ingestion of caffeine (5 mg/kg body weight) and a 75-g oral glucose load has been shown to elicit an acute insulin-insensitive environment in healthy and obese individuals and in those with type 2 diabetes.	Caffeine	29-37	insulin	Homo sapiens	123-130
18374908-10	2008	The results obtained thus suggest that nicotine and caffeine modulate MPTP-induced alterations in CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 expression/activity.	Caffeine	52-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	98-104
18374908-10	2008	The results obtained thus suggest that nicotine and caffeine modulate MPTP-induced alterations in CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 expression/activity.	Caffeine	52-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	106-112
18374908-10	2008	The results obtained thus suggest that nicotine and caffeine modulate MPTP-induced alterations in CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 expression/activity.	Caffeine	52-60	glutathione S-transferase, alpha 4	Mus musculus	130-137
18374908-10	2008	The results obtained thus suggest that nicotine and caffeine modulate MPTP-induced alterations in CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 expression/activity.	Caffeine	52-60	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	142-148
18715882-2	2008	In the metabolism of caffeine, the conversion of 1,7 dimethylxanthine (17X) to 1,7 dimethiylurate (17U) is catalyzed primarily by CYP2A6.	Caffeine	21-29	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	130-136
18387175-7	2008	We found that caffeine blocked high cholesterol diet-induced increases in extravasation of IgG and fibrinogen, increases in leakage of Evan"s blue dye, decreases in levels of the tight junction proteins occludin and ZO-1, increases in astrocytes activation and microglia density where IgG extravasation was present.	Caffeine	14-22	occludin	Oryctolagus cuniculus	203-211
19325779-7	2008	Additionally, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK) were activated in caffeine-treated osteoblasts.	Caffeine	104-112	p21 (RAC1) activated kinase 2	Homo sapiens	14-44
19325779-7	2008	Additionally, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK) were activated in caffeine-treated osteoblasts.	Caffeine	104-112	p21 (RAC1) activated kinase 2	Homo sapiens	46-50
19325779-7	2008	Additionally, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK) were activated in caffeine-treated osteoblasts.	Caffeine	104-112	mitogen-activated protein kinase 8	Homo sapiens	56-79
19325779-7	2008	Additionally, p21-activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK) were activated in caffeine-treated osteoblasts.	Caffeine	104-112	mitogen-activated protein kinase 8	Homo sapiens	81-84
19325779-8	2008	Experiments further found that PAK2 activity is required for caffeine-induced JNK activation and apoptosis.	Caffeine	61-69	p21 (RAC1) activated kinase 2	Homo sapiens	31-35
19325779-8	2008	Experiments further found that PAK2 activity is required for caffeine-induced JNK activation and apoptosis.	Caffeine	61-69	mitogen-activated protein kinase 8	Homo sapiens	78-81
19325779-9	2008	Importantly, our data also show that caffeine triggers cell death via inactivation of the survival signal, including the ERK- and Akt-mediated anti-apoptotic pathways.	Caffeine	37-45	mitogen-activated protein kinase 1	Homo sapiens	121-124
19325779-9	2008	Importantly, our data also show that caffeine triggers cell death via inactivation of the survival signal, including the ERK- and Akt-mediated anti-apoptotic pathways.	Caffeine	37-45	AKT serine/threonine kinase 1	Homo sapiens	130-133
18309092-7	2008	Caffeine had no effect on ERK1/2 phosphorylation (P &gt; 0.05) and increased alpha(2)-AMPK activity by 68% (P &lt; 0.05).	Caffeine	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	86-90
18279840-3	2008	CYP1A2 was found to be a key enzyme catalyzing 8-hydroxylation (72%) and substantially contributing to 3-N-demethylation (47%) and 1-N-demethylation (37.5%) at a caffeine concentration of 0.1mM (relevant to "the maximum therapeutic concentration in humans").	Caffeine	162-170	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
18448837-3	2008	Here, we report the effect of three coffee constituents, chlorogenic acid, caffeine, and N-methyl pyridinium ions, on the expression of the histamine receptor H2, the acetylcholine receptor M3, the gastrin receptor, the somatostatin receptor, and the H+,K+-ATPase.	Caffeine	75-83	histamine receptor H2	Homo sapiens	140-192
18448837-3	2008	Here, we report the effect of three coffee constituents, chlorogenic acid, caffeine, and N-methyl pyridinium ions, on the expression of the histamine receptor H2, the acetylcholine receptor M3, the gastrin receptor, the somatostatin receptor, and the H+,K+-ATPase.	Caffeine	75-83	cholecystokinin B receptor	Homo sapiens	198-214
18279840-6	2008	At higher substrate concentrations, the contribution of CYP1A2 to the metabolism of caffeine decreased in favor of CYP2C11 (N-demethylations) and CYP3A2 (mainly 8-hydroxylation).	Caffeine	84-92	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	56-62
18279840-6	2008	At higher substrate concentrations, the contribution of CYP1A2 to the metabolism of caffeine decreased in favor of CYP2C11 (N-demethylations) and CYP3A2 (mainly 8-hydroxylation).	Caffeine	84-92	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	115-122
18279840-6	2008	At higher substrate concentrations, the contribution of CYP1A2 to the metabolism of caffeine decreased in favor of CYP2C11 (N-demethylations) and CYP3A2 (mainly 8-hydroxylation).	Caffeine	84-92	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	146-152
18279840-8	2008	Therefore, caffeine may be used as a marker substance for assessing the activity of CYP1A2 in rats, using 8-hydroxylation (but not 3-N-demethylation-like in humans); moreover, caffeine may also be used to simultaneously, preliminarily estimate the activity of CYP2C using 7-N-demethylation as a marker reaction.	Caffeine	11-19	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	84-90
18279840-8	2008	Therefore, caffeine may be used as a marker substance for assessing the activity of CYP1A2 in rats, using 8-hydroxylation (but not 3-N-demethylation-like in humans); moreover, caffeine may also be used to simultaneously, preliminarily estimate the activity of CYP2C using 7-N-demethylation as a marker reaction.	Caffeine	11-19	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	260-265
18279840-8	2008	Therefore, caffeine may be used as a marker substance for assessing the activity of CYP1A2 in rats, using 8-hydroxylation (but not 3-N-demethylation-like in humans); moreover, caffeine may also be used to simultaneously, preliminarily estimate the activity of CYP2C using 7-N-demethylation as a marker reaction.	Caffeine	176-184	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	84-90
18279840-9	2008	Hence caffeine pharmacokinetics in rats may be changed by drugs affecting the activity of CYP1A2 and/or CYP2C, e.g. by some antidepressants.	Caffeine	6-14	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	90-96
18279840-9	2008	Hence caffeine pharmacokinetics in rats may be changed by drugs affecting the activity of CYP1A2 and/or CYP2C, e.g. by some antidepressants.	Caffeine	6-14	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	104-109
17594092-8	2008	Pemetrexed sensitization by caffeine was associated with an increase in pemetrexed-induced phosphorylation of ataxia-telangiectasia-mutated (ATM) and Chk1.	Caffeine	28-36	ATM serine/threonine kinase	Homo sapiens	110-139
17719086-4	2008	RyR-gated Ca2+ stores were confirmed by caffeine-induced increases in intracellular Ca2+ which were blocked by ryanodine (100 microM) and were independent of external Ca2+.	Caffeine	40-48	ryanodine receptor 2	Rattus norvegicus	0-3
17594092-8	2008	Pemetrexed sensitization by caffeine was associated with an increase in pemetrexed-induced phosphorylation of ataxia-telangiectasia-mutated (ATM) and Chk1.	Caffeine	28-36	ATM serine/threonine kinase	Homo sapiens	141-144
17719086-6	2008	Ca2+ influx via the glutamate receptor was found to elicit CICR via RyR-gated Ca2+ stores, as shown by the inhibition of the response by prior depletion of the Ca2+ stores with caffeine, the SERCA inhibitor thapsigargin, or ryanodine.	Caffeine	177-185	ryanodine receptor 2	Rattus norvegicus	68-71
17594092-8	2008	Pemetrexed sensitization by caffeine was associated with an increase in pemetrexed-induced phosphorylation of ataxia-telangiectasia-mutated (ATM) and Chk1.	Caffeine	28-36	checkpoint kinase 1	Homo sapiens	150-154
18283038-6	2008	In the colon tumors, beta-catenin mutations were detected at a higher frequency after caffeine posttreatment, and there was a shift toward more tumors harboring substitutions of Gly34 with correspondingly high protein and messenger RNA expression seen for both beta-catenin and c-Myc.	Caffeine	86-94	catenin beta 1	Rattus norvegicus	21-33
18441513-4	2008	This study investigated the effect of the Arg allele of beta(3)-AR on caffeine-induced increases in EE.	Caffeine	70-78	adrenoceptor beta 3	Homo sapiens	56-66
18381462-0	2008	Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.	Caffeine	10-18	ataxia telangiectasia and Rad3 related	Mus musculus	26-29
18381462-0	2008	Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.	Caffeine	10-18	checkpoint kinase 1	Mus musculus	30-34
18381462-4	2008	When given in the drinking water for 1 to 2 weeks before UVB, caffeine (0.4 mg/mL) markedly inhibited the UVB-induced phosphorylation of Chk1 on Ser(345) and caused premature expression of cyclin B1 in the epidermis.	Caffeine	62-70	checkpoint kinase 1	Mus musculus	137-141
18381462-4	2008	When given in the drinking water for 1 to 2 weeks before UVB, caffeine (0.4 mg/mL) markedly inhibited the UVB-induced phosphorylation of Chk1 on Ser(345) and caused premature expression of cyclin B1 in the epidermis.	Caffeine	62-70	cyclin B1	Mus musculus	189-198
18381462-10	2008	The ability of caffeine to promote the deletion of p53(-/-) keratinocytes may be relevant to its inhibitory effect on UVB-induced skin cancer.	Caffeine	15-23	transformation related protein 53, pseudogene	Mus musculus	51-54
18381462-11	2008	Our studies indicate that administration of caffeine enhances the removal of DNA-damaged cells by inhibiting the ATR-mediated phosphorylation of Chk1 and prematurely increasing the number of cyclin B1-containing cells that undergo lethal mitosis.	Caffeine	44-52	ataxia telangiectasia and Rad3 related	Mus musculus	113-116
18157525-3	2008	CYP1A2 activity was estimated by plasma paraxanthine/caffeine (17X/137X) ratio analysed by reversed-phase HPLC after oral administration of 100 mg caffeine.	Caffeine	53-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
18157525-3	2008	CYP1A2 activity was estimated by plasma paraxanthine/caffeine (17X/137X) ratio analysed by reversed-phase HPLC after oral administration of 100 mg caffeine.	Caffeine	147-155	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
18344132-1	2008	Following fixed-duration exercise of submaximal intensity, caffeine ingestion is associated with an attenuation of the exercise-induced decline in N-formyl-methionyl-phenyl-alanine (f-MLP) stimulated neutrophil oxidative burst.	Caffeine	59-67	cysteine and glycine rich protein 3	Homo sapiens	184-187
18381462-11	2008	Our studies indicate that administration of caffeine enhances the removal of DNA-damaged cells by inhibiting the ATR-mediated phosphorylation of Chk1 and prematurely increasing the number of cyclin B1-containing cells that undergo lethal mitosis.	Caffeine	44-52	checkpoint kinase 1	Mus musculus	145-149
18381462-11	2008	Our studies indicate that administration of caffeine enhances the removal of DNA-damaged cells by inhibiting the ATR-mediated phosphorylation of Chk1 and prematurely increasing the number of cyclin B1-containing cells that undergo lethal mitosis.	Caffeine	44-52	cyclin B1	Mus musculus	191-200
18191838-1	2008	Adenosine A2A receptor antagonists alleviate memory deficits caused by aging or by administration of beta-amyloid peptides in rodents, which is in accordance with the beneficial effects of caffeine consumption (an adenosine receptor antagonist) on memory performance in aged individuals and in preventing Alzheimer"s disease.	Caffeine	189-197	adenosine A2a receptor	Homo sapiens	0-22
18198354-0	2008	Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism.	Caffeine	0-8	myocyte enhancer factor 2A	Homo sapiens	53-57
18198354-0	2008	Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism.	Caffeine	0-8	solute carrier family 2 member 4	Homo sapiens	70-75
18198354-0	2008	Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism.	Caffeine	0-8	myocyte enhancer factor 2A	Homo sapiens	99-104
18198354-1	2008	This study was conducted to explore the mechanism by which caffeine increases GLUT4 expression in C(2)C(12) myotubes.	Caffeine	59-67	solute carrier family 2 member 4	Homo sapiens	78-83
18198354-3	2008	Chromatin immunoprecipitation (ChIP) assays revealed that caffeine treatment caused hyperacetylation of histone H3 at the myocyte enhancer factor 2 (MEF2) site on the Glut4 promoter (P &lt; 0.05) and increased the amount of MEF2A that was bound to this site approximately 2.2-fold (P &lt; 0.05) 4 h posttreatment compared with controls.	Caffeine	58-66	myocyte enhancer factor 2A	Homo sapiens	122-147
18198354-3	2008	Chromatin immunoprecipitation (ChIP) assays revealed that caffeine treatment caused hyperacetylation of histone H3 at the myocyte enhancer factor 2 (MEF2) site on the Glut4 promoter (P &lt; 0.05) and increased the amount of MEF2A that was bound to this site approximately 2.2-fold (P &lt; 0.05) 4 h posttreatment compared with controls.	Caffeine	58-66	myocyte enhancer factor 2A	Homo sapiens	149-153
18198354-3	2008	Chromatin immunoprecipitation (ChIP) assays revealed that caffeine treatment caused hyperacetylation of histone H3 at the myocyte enhancer factor 2 (MEF2) site on the Glut4 promoter (P &lt; 0.05) and increased the amount of MEF2A that was bound to this site approximately 2.2-fold (P &lt; 0.05) 4 h posttreatment compared with controls.	Caffeine	58-66	solute carrier family 2 member 4	Homo sapiens	167-172
18198354-3	2008	Chromatin immunoprecipitation (ChIP) assays revealed that caffeine treatment caused hyperacetylation of histone H3 at the myocyte enhancer factor 2 (MEF2) site on the Glut4 promoter (P &lt; 0.05) and increased the amount of MEF2A that was bound to this site approximately 2.2-fold (P &lt; 0.05) 4 h posttreatment compared with controls.	Caffeine	58-66	myocyte enhancer factor 2A	Homo sapiens	224-229
18198354-4	2008	These increases were accompanied by an approximately 1.8-fold rise (P &lt; 0.05 vs. control) in GLUT4 mRNA content at 6 h post-caffeine treatment.	Caffeine	127-135	solute carrier family 2 member 4	Homo sapiens	96-101
18198354-5	2008	Both immunoblot and immunocytochemical analyses showed reduced nuclear content of histone deacetylase-5 in caffeine-treated myotubes compared with controls at 0-2 h posttreatment.	Caffeine	107-115	histone deacetylase 5	Homo sapiens	82-103
18507003-8	2008	CONCLUSION: These findings provide new insights into the molecular mechanisms of the synergistic effect of caffeine related to p53 gene status in osteosarcoma, providing candidates for an assay of responsiveness to caffeine-potentiated chemotherapy for osteosarcoma.	Caffeine	107-115	tumor protein p53	Homo sapiens	127-130
18198354-6	2008	Inclusion of 10 mM dantrolene in the medium to prevent the increase in cytosolic Ca(2+), or 25 microM KN93 to inhibit Ca(2+)/calmodulin-dependent protein kinase (CaMK II), attenuated all the above caffeine-induced changes.	Caffeine	197-205	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	162-169
18198354-7	2008	These data indicate that caffeine increases GLUT4 expression by acetylating the MEF2 site to increase MEF2A binding via a mechanism that involves CaMK II.	Caffeine	25-33	solute carrier family 2 member 4	Homo sapiens	44-49
18198354-7	2008	These data indicate that caffeine increases GLUT4 expression by acetylating the MEF2 site to increase MEF2A binding via a mechanism that involves CaMK II.	Caffeine	25-33	myocyte enhancer factor 2A	Homo sapiens	80-84
18198354-7	2008	These data indicate that caffeine increases GLUT4 expression by acetylating the MEF2 site to increase MEF2A binding via a mechanism that involves CaMK II.	Caffeine	25-33	myocyte enhancer factor 2A	Homo sapiens	102-107
18198354-7	2008	These data indicate that caffeine increases GLUT4 expression by acetylating the MEF2 site to increase MEF2A binding via a mechanism that involves CaMK II.	Caffeine	25-33	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	146-153
18264130-6	2008	At least 2 weeks later, this whole procedure was repeated, but now in the presence of caffeine (90 microg min(-1) per 100 ml volume).	Caffeine	86-94	CD59 molecule (CD59 blood group)	Homo sapiens	106-112
17967164-5	2008	Ca2+-release assays revealed that both GFP-RyR2 fusion proteins formed caffeine- and ryanodine-sensitive Ca2+-release channels.	Caffeine	71-79	ryanodine receptor 2	Homo sapiens	43-47
17967164-6	2008	Further analyses using[3H]ryanodine binding demonstrated that the insertion of GFPinto RyR2-wt after Thr2023 reduced the sensitivity of the channelto activation by Ca2+ or caffeine.	Caffeine	172-180	ryanodine receptor 2	Homo sapiens	87-91
18264130-9	2008	This response was abolished by the concomitant infusion of caffeine (6.6+/-0.5, 10.2+/-0.6, 35.1+/-2.2 (caffeine) versus 7.4+/-0.4, 10.5+/-0.6, 33.7+/-2.2 ml min(-1)per 100 ml (caffeine/dipyridamole)).	Caffeine	59-67	CD59 molecule (CD59 blood group)	Homo sapiens	158-164
18070989-6	2008	High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.	Caffeine	20-28	adiponectin, C1Q and collagen domain containing	Homo sapiens	73-84
18353673-8	2008	The AMCase activity was significantly inhibited in all treated groups with all doses of allosamidin and caffeine except with the lowest concentration.	Caffeine	104-112	chitinase acidic	Homo sapiens	4-10
18418540-5	2008	We also show that the gating of recombinant RyR2 is indistinguishable from that of channels isolated from cardiac muscle when activated by cytosolic Ca2+, caffeine or suramin.	Caffeine	155-163	ryanodine receptor 2	Oryctolagus cuniculus	44-48
18179623-4	2008	Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches.	Caffeine	34-42	transformation related protein 53, pseudogene	Mus musculus	116-119
18179623-4	2008	Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches.	Caffeine	34-42	transformation related protein 53, pseudogene	Mus musculus	256-259
18179623-4	2008	Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches.	Caffeine	224-232	transformation related protein 53, pseudogene	Mus musculus	116-119
18179623-4	2008	Oral or topical administration of caffeine enhanced the removal of patches of epidermal cells with a mutant form of p53 protein that appeared early during the course of UVB-induced carcinogenesis, and oral administration of caffeine altered the profile of p53 mutations in the patches.	Caffeine	224-232	transformation related protein 53, pseudogene	Mus musculus	256-259
18207464-8	2008	This repression of degradation by ATM was both ATP-dependent and inhibited by the PIKK inhibitors wortmannin and caffeine.	Caffeine	113-121	ATM serine/threonine kinase	Homo sapiens	34-37
18353673-9	2008	A higher AMCase inhibition at 24h was found with allosamidin and caffeine compared to dexamethasone.	Caffeine	65-73	chitinase acidic	Homo sapiens	9-15
18353673-11	2008	AMCase inhibitors showed in this rabbit model of uveitis a notable control of inflammatory response with a significant reduction of AMCase activity in tears with caffeine and allosamidin.	Caffeine	162-170	chitinase acidic	Homo sapiens	0-6
18353673-11	2008	AMCase inhibitors showed in this rabbit model of uveitis a notable control of inflammatory response with a significant reduction of AMCase activity in tears with caffeine and allosamidin.	Caffeine	162-170	chitinase acidic	Homo sapiens	132-138
18661782-0	2008	[Electrophysiological study of effects of chronic injection of caffeine on defensive reflex conditioning in grape snail].	Caffeine	63-71	snail family transcriptional repressor 1	Homo sapiens	114-119
18661782-1	2008	It was found that chronic injection of caffeine to grape snail increases a velocity of elaboration of conditioned defensive reflex.	Caffeine	39-47	snail family transcriptional repressor 1	Homo sapiens	57-62
18201823-0	2008	Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson"s disease model of SH-SY5Y cells.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	28-31
18096513-4	2008	Ca(2+) imaging of intact myotubes expressing Ch-4 exhibit caffeine-induced Ca(2+) transients with inhibition kinetics that are significantly slower than those expressing (WT)RyR1 or (WT)RyR3.	Caffeine	58-66	ryanodine receptor 3	Homo sapiens	186-190
18096513-5	2008	Four new aspects of RyR regulation are evident: (1) high affinity (H) activation and low affinity (L) inhibition sites are allosterically coupled, (2) Ca(2+) facilitates removal of the inherent Mg(2+) block, (3) (WT)RyR3 exhibits reduced cooperativity between H activation sites when compared to (WT)RyR1, and (4) uncoupling of these sites in Ch-4 results in decreased rates of inactivation of caffeine-induced Ca(2+) transients.	Caffeine	394-402	ryanodine receptor 1	Homo sapiens	20-23
18201823-5	2008	Caffeine prevented the apoptotic cell death induced by serum/retinoic acid (RA) deprivation, MPP+, rotenone, and 6-OHDA in SH-SY5Y cells in a dose dependent manner.	Caffeine	0-8	M-phase phosphoprotein 6	Homo sapiens	93-96
18201823-6	2008	Caffeine lowered caspase-3 activity induced by serum/RA deprivation and 6-OHDA administration, and also decreased the number of apoptotic condensed and/or fragmented nuclei.	Caffeine	0-8	caspase 3	Homo sapiens	17-26
18201823-7	2008	Akt was phosphorylated 60 min after caffeine administration in a dose dependent manner; PI3K inhibitors, wortmannin and LY294002 canceled this cytoprotective effect of caffeine.	Caffeine	36-44	AKT serine/threonine kinase 1	Homo sapiens	0-3
18201823-7	2008	Akt was phosphorylated 60 min after caffeine administration in a dose dependent manner; PI3K inhibitors, wortmannin and LY294002 canceled this cytoprotective effect of caffeine.	Caffeine	168-176	AKT serine/threonine kinase 1	Homo sapiens	0-3
18201823-9	2008	These results suggest that caffeine has a cytoprotective effect due to the activation of the PI3K/Akt pathways in SH-SY5Y cells.	Caffeine	27-35	AKT serine/threonine kinase 1	Homo sapiens	98-101
17920329-5	2008	In contrast, JNK-dependent phosphorylation of T91/T93 requires continuous exposure to the drug and is impaired by caffeine treatment or alanine substitution of the adjacent threonine 95 (T95).	Caffeine	114-122	mitogen-activated protein kinase 8	Homo sapiens	13-16
18166280-5	2008	Disruption of GLN3 was found to partially suppress the caffeine sensitivity of the Deltasiw14 disruptant, while overexpression of GLN3 in wild-type cells caused caffeine sensitivity, providing the first evidence that Siw14 functions in the Gln3 regulatory network.	Caffeine	55-63	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	14-18
18166280-5	2008	Disruption of GLN3 was found to partially suppress the caffeine sensitivity of the Deltasiw14 disruptant, while overexpression of GLN3 in wild-type cells caused caffeine sensitivity, providing the first evidence that Siw14 functions in the Gln3 regulatory network.	Caffeine	161-169	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	130-134
18166280-6	2008	We also found that, unlike in a wild-type background, Gln3 accumulates in the nucleus whether cells are exposed or not to caffeine in the Deltasiw14 disruptant, and that this nuclear localization was abolished by disruption of NPR1.	Caffeine	122-130	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	54-58
18166280-8	2008	We conclude that Siw14 controls the intracellular localization of Gln3 in combination with Npr1, and one of the causes for the caffeine sensitivity of the Deltasiw14 disruptant was an accumulation of dephosphorylated Gln3 in the nucleus.	Caffeine	127-135	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	217-221
17884136-12	2008	CYP1A2 activity, measured by means of a caffeine-loading test, revealed no correlation with the prenatal and lactational exposures.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
18279358-4	2008	c-FOS in hypocretin-1-immunoreactive neurons, in hypothalamic nonhypocretin neurons and in the IGL was significantly increased by novel wheel running, gentle handling and physical restraint, but only weakly by systemic injections of modafinil (300 mg/kg) or caffeine (75 mg/kg), at doses that are strongly alerting.	Caffeine	258-266	proto-oncogene c-Fos	Mesocricetus auratus	0-5
17989210-6	2008	It was also found that SP significantly accelerated the decay of both electrically and caffeine-induced intracellular [Ca(2+)] transients, which were reversed by a selective PKC inhibitor chelerythrine.	Caffeine	87-95	protein kinase C, gamma	Rattus norvegicus	174-177
18769052-10	2008	Glucose depletion (for 48 hours) significantly increased Fluo3 fluorescence and annexin V-binding and decreased forward scatter, effects partially reversed by caffeine (500 microM).	Caffeine	159-167	annexin A5	Homo sapiens	80-89
18769052-11	2008	Low Cl(-) solution (Cl(-) exchanged by gluconate for 48 hours) similarly increased annexin V-binding and decreased forward scatter, effects again reversed by caffeine (50-500 microM).	Caffeine	158-166	annexin A5	Homo sapiens	83-92
17904720-4	2008	Harmane (50 and 100 microM) reversibly decreased spontaneous firing of action potentials and caffeine-induced bursting of CA3 neurons.	Caffeine	93-101	carbonic anhydrase 3	Homo sapiens	122-125
18266548-4	2008	This study compared the effects of a caffeine-containing (200 mg) supplement (CAF) or placebo in capsule form after prolonged wakefulness, in participants who varied in their level of habitual caffeine use.	Caffeine	37-45	lysine acetyltransferase 2B	Homo sapiens	78-81
17846099-2	2008	RBP elicited broadly tuned inhibition of various bitter substances including quinine-HCl, naringin, theobromine, caffeine, glycyl-L-phenylalanine (Gly-Phe), and denatonium benzoate, whereas several other proteins, such as ovalbumin (OVA) and beta-lactoglobulin, were ineffective in reducing bitterness of these same compounds.	Caffeine	113-121	riboflavin binding protein	Gallus gallus	0-3
17846099-3	2008	Both the bitter tastes of quinine and caffeine were reduced following an oral prerinse with RBP.	Caffeine	38-46	riboflavin binding protein	Gallus gallus	92-95
17920329-6	2008	Conversely, c-Jun mutations switching the T95/Q96 site into a canonical site for mitogen activated protein kinase (MAPK) phosphorylation (T95/P96) rescues T91/T93 phosphorylation in presence of caffeine, suggesting that a preceding phosphorylation at T95 exposes T91/T93 to JNK-dependent phosphorylation.	Caffeine	194-202	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
17920329-6	2008	Conversely, c-Jun mutations switching the T95/Q96 site into a canonical site for mitogen activated protein kinase (MAPK) phosphorylation (T95/P96) rescues T91/T93 phosphorylation in presence of caffeine, suggesting that a preceding phosphorylation at T95 exposes T91/T93 to JNK-dependent phosphorylation.	Caffeine	194-202	mitogen-activated protein kinase 8	Homo sapiens	274-277
18025108-0	2008	Caffeine regulates alternative splicing in a subset of cancer-associated genes: a role for SC35.	Caffeine	0-8	serine and arginine rich splicing factor 2	Homo sapiens	91-95
17932622-0	2008	Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	79-82
17932622-0	2008	Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	92-95
17932622-7	2008	Caffeine or rottlerin inhibited UV-induced phosphorylation of p38 MAPK, but not anisomycin-induced phosphorylation of p38 MAPK, suggesting that p38 MAPK is downstream of PKC.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	62-65
18569594-2	2008	In 83 out of 187 cases surveyed within the period 1991-1999, the NAT2 acetylator status was investigated by determining the molar ratio of an acetylated and a nonacetylated caffeine metabolite in urine (phenotyping) and/or by NAT2 genotyping according to standard polymerase chain reaction (PCR) protocol.	Caffeine	173-181	N-acetyltransferase 2	Homo sapiens	65-69
17932622-10	2008	Additionally, this inhibition occurs due to the inhibitory action of caffeine on ATM and PKC, resulting in the inhibition of p38 MAPK activation.	Caffeine	69-77	ATM serine/threonine kinase	Homo sapiens	81-84
18025108-3	2008	Here we report that caffeine regulates alternative splicing of a subset of cancer-associated genes, including the tumor suppressor KLF6.	Caffeine	20-28	Kruppel like factor 6	Homo sapiens	131-135
17932622-10	2008	Additionally, this inhibition occurs due to the inhibitory action of caffeine on ATM and PKC, resulting in the inhibition of p38 MAPK activation.	Caffeine	69-77	mitogen-activated protein kinase 14	Homo sapiens	125-128
18025108-5	2008	We have recapitulated caffeine-induced alternative splicing of KLF6 using a cell-based minigene assay and identified a "caffeine response element" within the KLF6 intronic sequence.	Caffeine	22-30	Kruppel like factor 6	Homo sapiens	63-67
18025108-5	2008	We have recapitulated caffeine-induced alternative splicing of KLF6 using a cell-based minigene assay and identified a "caffeine response element" within the KLF6 intronic sequence.	Caffeine	22-30	Kruppel like factor 6	Homo sapiens	158-162
18025108-5	2008	We have recapitulated caffeine-induced alternative splicing of KLF6 using a cell-based minigene assay and identified a "caffeine response element" within the KLF6 intronic sequence.	Caffeine	120-128	Kruppel like factor 6	Homo sapiens	63-67
18025108-5	2008	We have recapitulated caffeine-induced alternative splicing of KLF6 using a cell-based minigene assay and identified a "caffeine response element" within the KLF6 intronic sequence.	Caffeine	120-128	Kruppel like factor 6	Homo sapiens	158-162
18025108-8	2008	Importantly, SC35 is markedly induced by caffeine, and overexpression of SC35 is sufficient to mimic the effect of caffeine on KLF6 alternative splicing.	Caffeine	41-49	serine and arginine rich splicing factor 2	Homo sapiens	13-17
18025108-8	2008	Importantly, SC35 is markedly induced by caffeine, and overexpression of SC35 is sufficient to mimic the effect of caffeine on KLF6 alternative splicing.	Caffeine	115-123	serine and arginine rich splicing factor 2	Homo sapiens	73-77
18025108-8	2008	Importantly, SC35 is markedly induced by caffeine, and overexpression of SC35 is sufficient to mimic the effect of caffeine on KLF6 alternative splicing.	Caffeine	115-123	Kruppel like factor 6	Homo sapiens	127-131
18025108-9	2008	Taken together, our data implicate SC35 as a key player in caffeine-mediated splicing regulation.	Caffeine	59-67	serine and arginine rich splicing factor 2	Homo sapiens	35-39
18204825-7	2008	Differential regulation of NPS and NPSR transcripts was observed after caffeine or nicotine treatment, indicating complex interactions with adenosine and cholinergic systems.	Caffeine	71-79	neuropeptide S receptor 1	Homo sapiens	35-39
18082418-0	2008	Effects of acute caffeine administration on NOS and Bax/Bcl2 expression in the myocardium of rat.	Caffeine	17-25	BCL2 associated X, apoptosis regulator	Rattus norvegicus	52-55
18082418-0	2008	Effects of acute caffeine administration on NOS and Bax/Bcl2 expression in the myocardium of rat.	Caffeine	17-25	BCL2, apoptosis regulator	Rattus norvegicus	56-60
18025187-2	2007	This prompted the evaluation of the proinflammatory vs the anti-inflammatory effects of the widely consumed behavioral drug caffeine, as the psychoactive effects of caffeine are mediated largely by its antagonistic action on A2AR in the brain.	Caffeine	124-132	adenosine A2a receptor	Mus musculus	225-229
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	Caffeine	21-29	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	132-160
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	Caffeine	21-29	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	162-168
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	Caffeine	21-29	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	192-198
17827226-7	2007	The effects of HF on cytosolic and SR luminal Ca(2+) signals could be reasonably well mimicked by the RyR2 channel agonist caffeine.	Caffeine	123-131	ryanodine receptor 2	Canis lupus familiaris	102-106
17905651-0	2007	Caffeine effects on ERPs and performance in an auditory Go/NoGo task.	Caffeine	0-8	reticulon 4	Homo sapiens	59-63
18025187-7	2007	In contrast, a high dose of caffeine (100 mg/kg) completely blocked both liver damage and proinflammatory cytokine responses through an A2AR-independent mechanism.	Caffeine	28-36	adenosine A2a receptor	Mus musculus	136-140
17111100-5	2007	We found enhanced panicogenic sensitivity to sodium lactate and an increased intensity and a differential pattern of Fos expression after the administration of yohimbine or caffeine in TgNTRK3.	Caffeine	173-181	FBJ osteosarcoma oncogene	Mus musculus	117-120
18457008-0	2007	Caffeine reduces TNFalpha up-regulation in human adipose tissue primary culture.	Caffeine	0-8	tumor necrosis factor	Homo sapiens	17-25
18457008-3	2007	Since xanthine family compounds such as caffeine were shown to decrease inflammatory production by human blood cells, we investigated the possible effect of caffeine on Tumor Necrosis Factor alpha (TNFalpha) and Interleukin-6 (IL-6) expression by human adipose tissue primary culture.	Caffeine	157-165	tumor necrosis factor	Homo sapiens	169-196
18457008-3	2007	Since xanthine family compounds such as caffeine were shown to decrease inflammatory production by human blood cells, we investigated the possible effect of caffeine on Tumor Necrosis Factor alpha (TNFalpha) and Interleukin-6 (IL-6) expression by human adipose tissue primary culture.	Caffeine	157-165	tumor necrosis factor	Homo sapiens	198-206
18457008-11	2007	Thus, caffeine, by decreasing TNFalpha expression, could improve adipose tissue inflammation during obesity.	Caffeine	6-14	tumor necrosis factor	Homo sapiens	30-38
18088187-5	2007	The G2 arrest in p53+/+ cells was abrogated by caffeine, but not by staurosporine and UCN-01, whereas the G2 arrest in p53-/- cells was sensitive to all three inhibitors.	Caffeine	47-55	tumor protein p53	Homo sapiens	17-20
17872499-7	2007	Caffeine induced Ca(2+) release in 65% of FLV-CMs and approximately 38% of H1- and HES2-CMs.	Caffeine	0-8	H1.5 linker histone, cluster member	Homo sapiens	75-77
17872499-7	2007	Caffeine induced Ca(2+) release in 65% of FLV-CMs and approximately 38% of H1- and HES2-CMs.	Caffeine	0-8	hes family bHLH transcription factor 2	Homo sapiens	83-91
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	hes family bHLH transcription factor 2	Homo sapiens	128-132
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	H1.5 linker histone, cluster member	Homo sapiens	138-144
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	205-246
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	248-253
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	hes family bHLH transcription factor 2	Homo sapiens	311-315
17872499-8	2007	Ryanodine significantly reduced the electrically evoked Ca(2+) transient amplitudes of caffeine-responsive but not -insensitive HES2- and H1-CMs and slowed their upstroke; thapsigargin, which inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, reduced the amplitude of only caffeine-responsive HES2- and H1-CMs and slowed the decay.	Caffeine	87-95	H1.5 linker histone, cluster member	Homo sapiens	321-327
18042138-7	2007	Increases of [Ca2+](i) by releasing Ca2+ from intracellular stores (using caffeine, 10 mM) before the application of capsaicin increased the I(TRPV-1) (14.1 +/- 7%), while the I(Ca(V)) was decreased to 51.6 +/- 4.9% compared with control.	Caffeine	74-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-149
17998023-1	2007	In short-term studies, caffeine has been shown to increase insulin levels, reduce insulin sensitivity, and increase cortisol levels.	Caffeine	23-31	insulin	Homo sapiens	59-66
17998023-1	2007	In short-term studies, caffeine has been shown to increase insulin levels, reduce insulin sensitivity, and increase cortisol levels.	Caffeine	23-31	insulin	Homo sapiens	82-89
17998023-9	2007	Insulin levels were significantly higher (by 1.80 microU/mL; 95% confidence interval, 0.33-3.28) after caffeine intake than after placebo.	Caffeine	103-111	insulin	Homo sapiens	0-7
17998023-10	2007	The homeostasis model assessment index of insulin sensitivity was reduced by 35% (95% confidence interval, 7%-62%) by caffeine.	Caffeine	118-126	insulin	Homo sapiens	42-49
17998023-12	2007	This study provides evidence that daily caffeine intake reduces insulin sensitivity; the effect persists for at least a week and is evident up to 12 hours after administration.	Caffeine	40-48	insulin	Homo sapiens	64-71
18088187-8	2007	In the presence of caffeine Chk1 phosphorylation was inhibited regardless of p53 status.	Caffeine	19-27	checkpoint kinase 1	Homo sapiens	28-32
18088187-8	2007	In the presence of caffeine Chk1 phosphorylation was inhibited regardless of p53 status.	Caffeine	19-27	tumor protein p53	Homo sapiens	77-80
17925380-3	2007	We show that RyR1 is required for depolarization-induced Ca(2+) sparks, whereas RyR2 and RyR3 are sufficient for spontaneous or caffeine-induced Ca(2+) sparks.	Caffeine	128-136	ryanodine receptor 2, cardiac	Mus musculus	80-84
17727682-8	2007	Caffeine, an inhibitor of ataxia-telangiectasia mutated protein kinase, alleviated the genistein-induced p53 and CHK2 phosphorylation, suggesting the involvement of DNA damage at 30 microM.	Caffeine	0-8	tumor protein p53	Homo sapiens	105-108
17727682-8	2007	Caffeine, an inhibitor of ataxia-telangiectasia mutated protein kinase, alleviated the genistein-induced p53 and CHK2 phosphorylation, suggesting the involvement of DNA damage at 30 microM.	Caffeine	0-8	checkpoint kinase 2	Homo sapiens	113-117
17455238-9	2007	Inhibitor of the PI3K-family, LY294002 and the ATM/ATR inhibitor, caffeine, blocked vitamin C-induced growth arrest in B16F10 melanoma cells.	Caffeine	66-74	ataxia telangiectasia mutated	Mus musculus	47-50
17455238-9	2007	Inhibitor of the PI3K-family, LY294002 and the ATM/ATR inhibitor, caffeine, blocked vitamin C-induced growth arrest in B16F10 melanoma cells.	Caffeine	66-74	ataxia telangiectasia and Rad3 related	Mus musculus	51-54
17925380-3	2007	We show that RyR1 is required for depolarization-induced Ca(2+) sparks, whereas RyR2 and RyR3 are sufficient for spontaneous or caffeine-induced Ca(2+) sparks.	Caffeine	128-136	ryanodine receptor 3	Mus musculus	89-93
17638302-0	2007	Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.	Caffeine	27-35	ATM serine/threonine kinase	Homo sapiens	117-120
17638302-0	2007	Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.	Caffeine	27-35	tumor protein p53	Homo sapiens	121-124
17638302-0	2007	Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.	Caffeine	27-35	E2F transcription factor 1	Homo sapiens	125-130
17638302-1	2007	The aim of the present study was to evaluate the neuroprotective effects of caffeine, an inhibitor of ataxia telangiectasia mutated (ATM) enzyme and an antagonist of adenosine receptors, in two models of apoptosis in cerebellar granule neurons (CGNs): the inhibition of mitochondrial complex I by the neurotoxin MPP(+) and serum and potassium deprivation.	Caffeine	76-84	ATM serine/threonine kinase	Homo sapiens	102-131
17638302-1	2007	The aim of the present study was to evaluate the neuroprotective effects of caffeine, an inhibitor of ataxia telangiectasia mutated (ATM) enzyme and an antagonist of adenosine receptors, in two models of apoptosis in cerebellar granule neurons (CGNs): the inhibition of mitochondrial complex I by the neurotoxin MPP(+) and serum and potassium deprivation.	Caffeine	76-84	ATM serine/threonine kinase	Homo sapiens	133-136
17638302-4	2007	Our data indicate that the neuroprotective effects of caffeine in the MPP+ model of apoptosis are mediated through activation of the ATM/p53 pathway.	Caffeine	54-62	ATM serine/threonine kinase	Homo sapiens	133-136
17638302-4	2007	Our data indicate that the neuroprotective effects of caffeine in the MPP+ model of apoptosis are mediated through activation of the ATM/p53 pathway.	Caffeine	54-62	tumor protein p53	Homo sapiens	137-140
17638302-5	2007	In addition, caffeine decreased the expression of cyclin D and the transcription factor E2F-1, a regulator of apoptosis in neurons.	Caffeine	13-21	E2F transcription factor 1	Homo sapiens	88-93
18049373-4	2007	Caffeine exposure resulted in a transient reduction of glial fibrillary acidic protein and S100beta protein expression in various brain areas during the first 2 postnatal weeks (19.8% and 23.2% reduction in the hippocampus at P15, respectively).	Caffeine	0-8	S100 protein, beta polypeptide, neural	Mus musculus	91-99
18075470-1	2007	INTRODUCTION: Cytochrome P450 1A2 (CYP 1A2) is responsible for more than 90% of caffeine clearance.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-33
18049373-4	2007	Caffeine exposure resulted in a transient reduction of glial fibrillary acidic protein and S100beta protein expression in various brain areas during the first 2 postnatal weeks (19.8% and 23.2% reduction in the hippocampus at P15, respectively).	Caffeine	0-8	cyclin dependent kinase inhibitor 2B	Mus musculus	226-229
18075470-1	2007	INTRODUCTION: Cytochrome P450 1A2 (CYP 1A2) is responsible for more than 90% of caffeine clearance.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	35-42
18195463-8	2007	We conclude that the tested antidepressant drugs may affect the metabolism of caffeine not only in a direct way (binding to the enzyme), but also indirectly via inducing CYP1A2 (sertraline and mirtazapine) and CYP2C isoforms (fluoxetine, sertraline, mirtazapine) after prolonged administration.	Caffeine	78-86	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	170-176
17712038-6	2007	In LNCaP cells, AIbZIP was processed to its transcriptionally active form by drugs that deplete ER calcium stores (i.e., A23187 and caffeine), but it was unaffected by an inhibitor of protein glycosylation (tunicamycin).	Caffeine	132-140	cAMP responsive element binding protein 3 like 4	Homo sapiens	16-22
18195463-8	2007	We conclude that the tested antidepressant drugs may affect the metabolism of caffeine not only in a direct way (binding to the enzyme), but also indirectly via inducing CYP1A2 (sertraline and mirtazapine) and CYP2C isoforms (fluoxetine, sertraline, mirtazapine) after prolonged administration.	Caffeine	78-86	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	210-215
18195463-9	2007	In addition, the presented data provide further experimental evidence for the importance of the subfamily CYP2C for the 7-N-demethylation of caffeine in the rat.	Caffeine	141-149	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	106-111
17616645-8	2007	In "model" slices in which the [Ca(2+)](i) was constantly maintained at an elevated level by pretreatment of slices with caffeine and ryanodine, the addition of ET increased bronchiole and arteriole contraction.	Caffeine	121-129	endothelin 1	Mus musculus	161-163
17892993-13	2007	In cohort 2, caffeine administration was associated with lower platelet activation markers (P-selectin, PAC-1 binding), without significant effect on aggregation.	Caffeine	13-21	selectin P	Homo sapiens	92-102
17892993-13	2007	In cohort 2, caffeine administration was associated with lower platelet activation markers (P-selectin, PAC-1 binding), without significant effect on aggregation.	Caffeine	13-21	dual specificity phosphatase 2	Homo sapiens	104-109
17726372-4	2007	Chemical inhibition of ATR/ATM by caffeine led to enhanced centrosomal Chk1 deposition associated with nuclear Chk1 depletion.	Caffeine	34-42	ATR serine/threonine kinase	Homo sapiens	23-26
17726372-4	2007	Chemical inhibition of ATR/ATM by caffeine led to enhanced centrosomal Chk1 deposition associated with nuclear Chk1 depletion.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	27-30
17726372-4	2007	Chemical inhibition of ATR/ATM by caffeine led to enhanced centrosomal Chk1 deposition associated with nuclear Chk1 depletion.	Caffeine	34-42	checkpoint kinase 1	Homo sapiens	71-75
17726372-4	2007	Chemical inhibition of ATR/ATM by caffeine led to enhanced centrosomal Chk1 deposition associated with nuclear Chk1 depletion.	Caffeine	34-42	checkpoint kinase 1	Homo sapiens	111-115
17704360-9	2007	TP53-mutated glioma cell lines demonstrated a very prominent dose-responsive G2 checkpoint and were sensitized to radiation by caffeine, which inhibits G2/S phase checkpoint activation.	Caffeine	127-135	tumor protein p53	Homo sapiens	0-4
17510082-8	2007	Aspirin induced the phosphorylation of p53 at residue Ser15 within 8 h in a caffeine-dependent manner, and also caused the activation of checkpoint kinase 2 and the cleavage of caspase 7.	Caffeine	76-84	tumor protein p53	Homo sapiens	39-42
17656431-7	2007	CGRP treatment also drastically increased caffeine-induced Ca(2+) release in approximately 4 h ( approximately 400%).	Caffeine	42-50	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	0-4
17823102-5	2007	The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 substrates, such as caffeine, clozapine, fluvoxamine, olanzapine, tacrine, and theophylline.	Caffeine	107-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
17524180-3	2007	Our objective was to determine whether acute caffeine ingestion continued to alter insulin, glucose, NEFA and adrenaline during an oral glucose tolerance test (OGTT) following 14 d of caffeine consumption.	Caffeine	45-53	insulin	Homo sapiens	83-90
17869311-8	2007	Behaviorally, p50 KO mice exhibited increased locomotor activity relative to that of F2 mice after caffeine ingestion.	Caffeine	99-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-17
17869311-10	2007	Dysregulation of these receptors in the striata of p50 KO mice might sensitize these animals to locomotor stimulatory action of caffeine.	Caffeine	128-136	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	51-54
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	vascular endothelial growth factor A	Homo sapiens	206-210
17805088-3	2007	Sixty minutes before exercise, participants ingested 6 mg.kg(-1) body mass of caffeine (CAF) or placebo (PLA), then during exercise they consumed a 6% CHO or placebo (PLA) drink, providing CAF/CHO, PLA/CHO, CAF/PLA, and PLA/PLA conditions.	Caffeine	78-86	lysine acetyltransferase 2B	Homo sapiens	88-91
17488804-0	2007	Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.	Caffeine	0-8	vascular endothelial growth factor A	Homo sapiens	85-119
17488804-0	2007	Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.	Caffeine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	vascular endothelial growth factor A	Homo sapiens	243-247
17488804-7	2007	Pretreatment of cells with caffeine significantly reduces adenosine-induced VEGF promoter activity and VEGF and IL-8 expression.	Caffeine	27-35	vascular endothelial growth factor A	Homo sapiens	76-80
17488804-7	2007	Pretreatment of cells with caffeine significantly reduces adenosine-induced VEGF promoter activity and VEGF and IL-8 expression.	Caffeine	27-35	vascular endothelial growth factor A	Homo sapiens	103-107
17488804-7	2007	Pretreatment of cells with caffeine significantly reduces adenosine-induced VEGF promoter activity and VEGF and IL-8 expression.	Caffeine	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	mitogen-activated protein kinase 1	Homo sapiens	65-106
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
17405829-8	2007	We conclude that a SR Ca(2+)-activated CaMKK may control alpha(1)-AMPK activation and be necessary for caffeine-stimulated glucose uptake in mouse soleus muscle.	Caffeine	103-111	calcium/calmodulin-dependent protein kinase kinase 1, alpha	Mus musculus	39-44
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	mitogen-activated protein kinase 3	Homo sapiens	108-114
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	mitogen-activated protein kinase 1	Homo sapiens	117-120
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	AKT serine/threonine kinase 1	Homo sapiens	126-129
17664435-3	2007	Although orally administrated caffeine (0.1 mg/ml in the drinking water) or voluntary exercise for 2 weeks caused only a small nonsignificant stimulation of UVB-induced increase in the percentage of phospho-p53 (Ser-15)-positive cells in the epidermis (27 or 18%, respectively), the combination of the two treatments enhanced the UVB-induced increase in phospho-p53 (Ser-15)-positive cells by 99%.	Caffeine	30-38	transformation related protein 53, pseudogene	Mus musculus	207-210
17664435-3	2007	Although orally administrated caffeine (0.1 mg/ml in the drinking water) or voluntary exercise for 2 weeks caused only a small nonsignificant stimulation of UVB-induced increase in the percentage of phospho-p53 (Ser-15)-positive cells in the epidermis (27 or 18%, respectively), the combination of the two treatments enhanced the UVB-induced increase in phospho-p53 (Ser-15)-positive cells by 99%.	Caffeine	30-38	transformation related protein 53, pseudogene	Mus musculus	362-365
17586686-3	2007	After DNA damage, the level of Cul7 protein increased in a caffeine-sensitive, but p53-independent, manner.	Caffeine	59-67	cullin 7	Homo sapiens	31-35
17297454-5	2007	Moreover, incubation of cells with caffeine, which inhibits ataxia telangiectasia mutated (ATM)/ATR, or transfection of cells with short interfering RNA targeting ATR abrogated IR-induced Chk1 phosphorylation and G2/M arrest but had no effect on IR-induced ERK1/2 activation.	Caffeine	35-43	ATM serine/threonine kinase	Homo sapiens	60-89
17297454-5	2007	Moreover, incubation of cells with caffeine, which inhibits ataxia telangiectasia mutated (ATM)/ATR, or transfection of cells with short interfering RNA targeting ATR abrogated IR-induced Chk1 phosphorylation and G2/M arrest but had no effect on IR-induced ERK1/2 activation.	Caffeine	35-43	ATM serine/threonine kinase	Homo sapiens	91-94
17297454-5	2007	Moreover, incubation of cells with caffeine, which inhibits ataxia telangiectasia mutated (ATM)/ATR, or transfection of cells with short interfering RNA targeting ATR abrogated IR-induced Chk1 phosphorylation and G2/M arrest but had no effect on IR-induced ERK1/2 activation.	Caffeine	35-43	ATR serine/threonine kinase	Homo sapiens	96-99
17297454-5	2007	Moreover, incubation of cells with caffeine, which inhibits ataxia telangiectasia mutated (ATM)/ATR, or transfection of cells with short interfering RNA targeting ATR abrogated IR-induced Chk1 phosphorylation and G2/M arrest but had no effect on IR-induced ERK1/2 activation.	Caffeine	35-43	checkpoint kinase 1	Homo sapiens	188-192
17297454-5	2007	Moreover, incubation of cells with caffeine, which inhibits ataxia telangiectasia mutated (ATM)/ATR, or transfection of cells with short interfering RNA targeting ATR abrogated IR-induced Chk1 phosphorylation and G2/M arrest but had no effect on IR-induced ERK1/2 activation.	Caffeine	35-43	mitogen-activated protein kinase 3	Homo sapiens	257-263
17184930-5	2007	Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)&gt;.465, p&lt;.001).	Caffeine	215-223	CD4 molecule	Homo sapiens	10-13
17184930-5	2007	Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)&gt;.465, p&lt;.001).	Caffeine	215-223	CD4 molecule	Homo sapiens	14-17
17616786-0	2007	Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption.	Caffeine	79-87	adenosine A2a receptor	Homo sapiens	28-50
17616786-2	2007	OBJECTIVE: We examined whether genetic variability in caffeine metabolism [cytochrome P450 1A2 (CYP1A2) -163A--&gt;C] or the main target of caffeine action in the nervous system [adenosine A(2A) receptor (ADORA2A) 1083C--&gt;T] is associated with habitual caffeine consumption.	Caffeine	54-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-94
17616786-5	2007	RESULTS: The ADORA2A, but not the CYP1A2, genotype was associated with different amounts of caffeine intake.	Caffeine	92-100	adenosine A2a receptor	Homo sapiens	13-20
17616786-6	2007	Compared with persons consuming &lt;100 mg caffeine/d, the odds ratios for having the ADORA2A TT genotype were 0.74 (95% CI: 0.53, 1.03), 0.63 (95% CI: 0.48, 0.83), and 0.57 (95% CI: 0.42, 0.77) for those consuming 100-200, &gt;200-400, and &gt;400 mg caffeine/d, respectively.	Caffeine	43-51	adenosine A2a receptor	Homo sapiens	86-93
17616786-6	2007	Compared with persons consuming &lt;100 mg caffeine/d, the odds ratios for having the ADORA2A TT genotype were 0.74 (95% CI: 0.53, 1.03), 0.63 (95% CI: 0.48, 0.83), and 0.57 (95% CI: 0.42, 0.77) for those consuming 100-200, &gt;200-400, and &gt;400 mg caffeine/d, respectively.	Caffeine	252-260	adenosine A2a receptor	Homo sapiens	86-93
17616786-8	2007	Persons with the ADORA2A TT genotype also were significantly more likely to consume less caffeine (ie, &lt;100 mg/d) than were carriers of the C allele [P=0.011 (nonsmokers), P=0.008 (smokers)].	Caffeine	89-97	adenosine A2a receptor	Homo sapiens	17-24
17616786-9	2007	CONCLUSION: Our findings show that the probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases.	Caffeine	111-119	adenosine A2a receptor	Homo sapiens	65-72
17558310-1	2007	The 1976C&gt;T polymorphism in the adenosine A2A receptor gene (ADORA2A) modulates the psychological response to administration of the adenosine receptor antagonist caffeine.	Caffeine	165-173	adenosine A2a receptor	Homo sapiens	35-57
17564586-6	2007	Maternal and newborn variants in the CYP1A2 and CYP2E1 genes involved in the metabolism of caffeine were determined.	Caffeine	91-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
17564586-6	2007	Maternal and newborn variants in the CYP1A2 and CYP2E1 genes involved in the metabolism of caffeine were determined.	Caffeine	91-99	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	48-54
17498647-5	2007	Measurement of intracellular pH confirmed that caffeine was not directly inhibiting hPepT1 but rather having an indirect effect through inhibition of NHE3 activity.	Caffeine	47-55	solute carrier family 15 member 1	Homo sapiens	84-90
17498647-5	2007	Measurement of intracellular pH confirmed that caffeine was not directly inhibiting hPepT1 but rather having an indirect effect through inhibition of NHE3 activity.	Caffeine	47-55	solute carrier family 9 member A3	Homo sapiens	150-154
17498647-7	2007	Uptake of beta-alanine, a substrate for the H(+)-coupled amino acid transporter hPAT1 (SLC36A1), was also inhibited by caffeine.	Caffeine	119-127	solute carrier family 36 member 1	Homo sapiens	80-85
17498647-7	2007	Uptake of beta-alanine, a substrate for the H(+)-coupled amino acid transporter hPAT1 (SLC36A1), was also inhibited by caffeine.	Caffeine	119-127	solute carrier family 36 member 1	Homo sapiens	87-94
17558310-1	2007	The 1976C&gt;T polymorphism in the adenosine A2A receptor gene (ADORA2A) modulates the psychological response to administration of the adenosine receptor antagonist caffeine.	Caffeine	165-173	adenosine A2a receptor	Homo sapiens	64-71
17416530-0	2007	Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues.	Caffeine	64-72	monoamine oxidase B	Homo sapiens	14-33
17379641-5	2007	Spontaneous Ca2+ transients were suppressed by the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) blocker 2-aminoethoxydiphenyl borate (2-APB) and the phospholipase C blocker U73122 but continued in the presence of caffeine.	Caffeine	219-227	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	81-94
17379641-5	2007	Spontaneous Ca2+ transients were suppressed by the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) blocker 2-aminoethoxydiphenyl borate (2-APB) and the phospholipase C blocker U73122 but continued in the presence of caffeine.	Caffeine	219-227	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	96-100
17379641-5	2007	Spontaneous Ca2+ transients were suppressed by the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) blocker 2-aminoethoxydiphenyl borate (2-APB) and the phospholipase C blocker U73122 but continued in the presence of caffeine.	Caffeine	219-227	arginyl aminopeptidase (aminopeptidase B)	Mus musculus	142-145
17488713-4	2007	We found that treatment of rat epitrochlearis muscles with a concentration of caffeine that raises cytosolic calcium to a concentration too low to cause contraction induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha expression and mitochondrial biogenesis.	Caffeine	78-86	PPARG coactivator 1 alpha	Rattus norvegicus	186-253
17452324-5	2007	These functional analyses revealed that RyR2(S437-GFP) forms a caffeine- and ryanodine-sensitive Ca(2+) release channel that possesses Ca(2+) and caffeine dependence of activation indistinguishable from that of wild type (wt) RyR2.	Caffeine	63-71	ryanodine receptor 2	Homo sapiens	40-44
17452324-5	2007	These functional analyses revealed that RyR2(S437-GFP) forms a caffeine- and ryanodine-sensitive Ca(2+) release channel that possesses Ca(2+) and caffeine dependence of activation indistinguishable from that of wild type (wt) RyR2.	Caffeine	63-71	ryanodine receptor 2	Homo sapiens	226-230
17452324-5	2007	These functional analyses revealed that RyR2(S437-GFP) forms a caffeine- and ryanodine-sensitive Ca(2+) release channel that possesses Ca(2+) and caffeine dependence of activation indistinguishable from that of wild type (wt) RyR2.	Caffeine	146-154	ryanodine receptor 2	Homo sapiens	40-44
17303650-3	2007	By performing single-channel recordings in the cell-attached configuration, we found that bath application of caffeine significantly enhanced the currents of Kir6.2/SUR1 channels, a neuronal/pancreatic K(ATP) channel isoform, expressed in transfected human embryonic kidney (HEK)293 cells in a concentration-dependent manner.	Caffeine	110-118	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	158-164
17303650-3	2007	By performing single-channel recordings in the cell-attached configuration, we found that bath application of caffeine significantly enhanced the currents of Kir6.2/SUR1 channels, a neuronal/pancreatic K(ATP) channel isoform, expressed in transfected human embryonic kidney (HEK)293 cells in a concentration-dependent manner.	Caffeine	110-118	ATP binding cassette subfamily C member 8	Homo sapiens	165-169
17303650-7	2007	In contrast, the activity of Kir6.2/SUR1 channels was decreased rather than increased by caffeine in cell-free inside-out patches, while tetrameric Kir6.2LRKR368/369/370/371AAAA channels were suppressed regardless of patch configurations.	Caffeine	89-97	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	29-35
17303650-7	2007	In contrast, the activity of Kir6.2/SUR1 channels was decreased rather than increased by caffeine in cell-free inside-out patches, while tetrameric Kir6.2LRKR368/369/370/371AAAA channels were suppressed regardless of patch configurations.	Caffeine	89-97	ATP binding cassette subfamily C member 8	Rattus norvegicus	36-40
17303650-8	2007	Caffeine also enhanced the single-channel currents of recombinant Kir6.2/SUR2B channels, a nonvascular smooth muscle K(ATP) channel isoform, although the increase was smaller.	Caffeine	0-8	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	66-72
17303650-10	2007	Taken together, our data suggest that caffeine exerts dual regulation on the function of K(ATP) channels: an inhibitory regulation that acts directly on Kir6.2 or some closely associated regulatory protein(s), and a sulfonylurea receptor (SUR)-dependent stimulatory regulation that requires cGMP-PKG and intracellular Ca(2+)-dependent signaling.	Caffeine	38-46	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	153-159
17303650-10	2007	Taken together, our data suggest that caffeine exerts dual regulation on the function of K(ATP) channels: an inhibitory regulation that acts directly on Kir6.2 or some closely associated regulatory protein(s), and a sulfonylurea receptor (SUR)-dependent stimulatory regulation that requires cGMP-PKG and intracellular Ca(2+)-dependent signaling.	Caffeine	38-46	ATP binding cassette subfamily C member 8	Homo sapiens	239-242
17416530-3	2007	In the present study, we have prepared additional caffeine and benzimidazole analogues in an attempt to identify compounds with improved MAO-B inhibition potency while still acting reversibly.	Caffeine	50-58	monoamine oxidase B	Homo sapiens	137-142
17603224-2	2007	In particular, up to 60-fold interindividual variation has been detected in the activity of CYP1A2, which is involved in the metabolism of caffeine, several drugs and various toxic and carcinogenic compounds.	Caffeine	139-147	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	92-98
17292679-5	2007	Consistent with this hypothesis, the inhibitors caffeine and UCN-01 also abrogate the ATR- and Chk1-mediated delay in progression through S-phase.	Caffeine	48-56	checkpoint kinase 1	Homo sapiens	95-99
17370067-2	2007	METHODS: CYP1A2 enzyme activity was determined in 194 and 150 healthy Swedish and Korean subjects, respectively, on the basis of the 4-h plasma paraxanthine/caffeine (17X/137X) ratio determined using high-performance liquid chromatography.	Caffeine	157-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15
17521300-7	2007	The paraxanthine/caffeine ratio (CYP1A2) was decreased on day 1 after administration of artemisinin [0.27 (0.18-0.39)], arteether [0.70 (0.55-0.89)] and dihydroartemisinin [0.73 (0.59-0.90)] compared with day -6.	Caffeine	17-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
17468739-3	2007	Caffeine abrogated this amplification in both ATM (ataxia telangiectasia, mutated)- and ATR (ATM and Rad3-related)-defective cells, indicating a complementary role for these DNA-damage-responsive kinases in promoting centrosome amplification.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	46-91
17468739-3	2007	Caffeine abrogated this amplification in both ATM (ataxia telangiectasia, mutated)- and ATR (ATM and Rad3-related)-defective cells, indicating a complementary role for these DNA-damage-responsive kinases in promoting centrosome amplification.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	46-49
17209005-11	2007	Sarcoplasmic reticulum Ca(2+) load measured as normalized integrated Na(+)/Ca(2+) exchange current after rapid caffeine application was increased by 48% in VLCAD(-/-) cells.	Caffeine	111-119	acyl-Coenzyme A dehydrogenase, very long chain	Mus musculus	156-161
17086209-5	2007	In this approach, inhibition of NMD with emetine is complemented with inhibiting NMD by blocking the phosphorylation of the hUpf1 protein with caffeine.	Caffeine	143-151	UPF1 RNA helicase and ATPase	Homo sapiens	124-129
17409144-7	2007	This G2/M arrest in response to nocodazole was also abolished by caffeine, suggesting an involvement of the ATM/ATR signaling pathway in the regulation of this cell cycle checkpoint.	Caffeine	65-73	ATM serine/threonine kinase	Homo sapiens	108-111
17515540-11	2007	CONCLUSIONS: Paroxysmal nonkinesigenic dyskinesia (PNKD) should be strictly defined based on age at onset and ability to precipitate attacks with caffeine and alcohol.	Caffeine	146-154	PNKD metallo-beta-lactamase domain containing	Homo sapiens	51-55
17445533-8	2007	These findings indicate that long-term caffeine consumption can help alleviate diabetic symptoms by enhancing insulin sensitivity and beta-cell function through improved insulin/IGF-1 signaling via induction of insulin receptor substrate 2 in mildly diabetic rats.	Caffeine	39-47	insulin-like growth factor 1	Rattus norvegicus	178-183
17388926-6	2007	Histologically, topical caffeine application after a single dose of UVB more than doubled the number of apoptotic keratinocytes as evaluated by sunburn cell formation, caspase 3 cleavage and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) staining.	Caffeine	24-32	caspase 3	Mus musculus	168-177
17388926-6	2007	Histologically, topical caffeine application after a single dose of UVB more than doubled the number of apoptotic keratinocytes as evaluated by sunburn cell formation, caspase 3 cleavage and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) staining.	Caffeine	24-32	deoxynucleotidyltransferase, terminal	Mus musculus	191-228
17507615-3	2007	A common A to C polymorphism in the CYP1A2 gene is associated with decreased enzyme inducibility and impaired caffeine metabolism.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	36-42
17507615-10	2007	This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations.	Caffeine	25-33	BRCA1 DNA repair associated	Homo sapiens	81-86
17599854-7	2007	Administration of caffeine in decaffeinated coffee increased postprandial glucose and insulin responses (both P = 0.02).	Caffeine	18-26	insulin	Homo sapiens	86-93
17599854-8	2007	The mean plasma glucose AUC2h was 28% larger and the mean plasma insulin AUC2h was 19% larger after administration of caffeine than after administration of placebo.	Caffeine	118-126	insulin	Homo sapiens	65-72
17329997-0	2007	A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep.	Caffeine	106-114	adenosine A2a receptor	Homo sapiens	27-49
17329997-0	2007	A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep.	Caffeine	106-114	adenosine A2a receptor	Homo sapiens	56-63
17329997-5	2007	These data demonstrate a role of adenosine A2A receptors for sleep in humans, and suggest that a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep.	Caffeine	178-186	adenosine A2a receptor	Homo sapiens	117-124
17167777-3	2007	These effects were abrogated by caffeine, which inhibits the Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases.	Caffeine	32-40	ATM serine/threonine kinase	Homo sapiens	61-90
17167777-3	2007	These effects were abrogated by caffeine, which inhibits the Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases.	Caffeine	32-40	ATM serine/threonine kinase	Homo sapiens	92-95
17167777-3	2007	These effects were abrogated by caffeine, which inhibits the Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases.	Caffeine	32-40	ATM serine/threonine kinase	Homo sapiens	101-104
17167777-3	2007	These effects were abrogated by caffeine, which inhibits the Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases.	Caffeine	32-40	ATR serine/threonine kinase	Homo sapiens	124-127
17445533-0	2007	Long-term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin-like growth factor 1 signaling in diabetic rats.	Caffeine	25-33	insulin-like growth factor 1	Rattus norvegicus	112-148
17445533-8	2007	These findings indicate that long-term caffeine consumption can help alleviate diabetic symptoms by enhancing insulin sensitivity and beta-cell function through improved insulin/IGF-1 signaling via induction of insulin receptor substrate 2 in mildly diabetic rats.	Caffeine	39-47	insulin receptor substrate 2	Rattus norvegicus	211-239
17652830-8	2007	beta-Naphthoflavone (mainly a CYP1A inducer and CYP2C11 inhibitor) potently accelerated the metabolism of caffeine, the effect on 7-N-demethylation being the weakest.	Caffeine	106-114	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	48-55
17652830-11	2007	Phenobarbital (an inducer of CYP2B and other CYPs and a CYP2C11 inhibitor) moderately stimulated the metabolism of caffeine, but practically did not affect 7-N-demethylation.	Caffeine	115-123	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	56-63
17652830-13	2007	The presently obtained data confirm the pivotal role of CYP1A2 in the metabolism of caffeine, as well as the involvement of CYP3A in the 8-hydroxylation of caffeine and that of CYP2C11 in its 7-N-demethylation.	Caffeine	84-92	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	56-62
17652830-13	2007	The presently obtained data confirm the pivotal role of CYP1A2 in the metabolism of caffeine, as well as the involvement of CYP3A in the 8-hydroxylation of caffeine and that of CYP2C11 in its 7-N-demethylation.	Caffeine	156-164	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	124-129
17259277-6	2007	However, in the presence of low concentrations of caffeine, SOICR could be triggered in these RyR1-expressing cells.	Caffeine	50-58	ryanodine receptor 1	Homo sapiens	94-98
17652830-0	2007	Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat.	Caffeine	44-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	10-25
17652830-0	2007	Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat.	Caffeine	44-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	27-30
17652830-1	2007	Our previous studies, carried out using rat cDNA-expressed cytochrome P450 (CYP) isoforms, liver microsomes and specific CYP inhibitors, showed that the 1-N- and 3-N-demethylation of caffeine at a therapeutic concentration was predominantly catalyzed by CYP1A2 and CYP2C, its 7-N-demethylation was governed by P450s of the CYP2C subfamily, while its 8-hydroxylation was specifically mediated by CYP1A2.	Caffeine	183-191	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-74
17652830-1	2007	Our previous studies, carried out using rat cDNA-expressed cytochrome P450 (CYP) isoforms, liver microsomes and specific CYP inhibitors, showed that the 1-N- and 3-N-demethylation of caffeine at a therapeutic concentration was predominantly catalyzed by CYP1A2 and CYP2C, its 7-N-demethylation was governed by P450s of the CYP2C subfamily, while its 8-hydroxylation was specifically mediated by CYP1A2.	Caffeine	183-191	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	76-79
17652830-1	2007	Our previous studies, carried out using rat cDNA-expressed cytochrome P450 (CYP) isoforms, liver microsomes and specific CYP inhibitors, showed that the 1-N- and 3-N-demethylation of caffeine at a therapeutic concentration was predominantly catalyzed by CYP1A2 and CYP2C, its 7-N-demethylation was governed by P450s of the CYP2C subfamily, while its 8-hydroxylation was specifically mediated by CYP1A2.	Caffeine	183-191	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	121-124
17652830-1	2007	Our previous studies, carried out using rat cDNA-expressed cytochrome P450 (CYP) isoforms, liver microsomes and specific CYP inhibitors, showed that the 1-N- and 3-N-demethylation of caffeine at a therapeutic concentration was predominantly catalyzed by CYP1A2 and CYP2C, its 7-N-demethylation was governed by P450s of the CYP2C subfamily, while its 8-hydroxylation was specifically mediated by CYP1A2.	Caffeine	183-191	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	254-260
17652830-1	2007	Our previous studies, carried out using rat cDNA-expressed cytochrome P450 (CYP) isoforms, liver microsomes and specific CYP inhibitors, showed that the 1-N- and 3-N-demethylation of caffeine at a therapeutic concentration was predominantly catalyzed by CYP1A2 and CYP2C, its 7-N-demethylation was governed by P450s of the CYP2C subfamily, while its 8-hydroxylation was specifically mediated by CYP1A2.	Caffeine	183-191	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	395-401
17373724-2	2007	In this report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for patients with Parkinson"s disease.	Caffeine	53-61	zinc finger protein, FOG family member 1	Homo sapiens	95-98
17373724-3	2007	Different subtypes of FOG showed different therapeutic responses to caffeine.	Caffeine	68-76	zinc finger protein, FOG family member 1	Homo sapiens	22-25
17373724-4	2007	Caffeine improved "total akinesia" type of FOG, but had no effect on "trembling in place."	Caffeine	0-8	zinc finger protein, FOG family member 1	Homo sapiens	43-46
17373724-5	2007	Tolerance developed to the beneficial effect of caffeine on FOG within a few months, but a 2-week caffeine withdrawal period could restore the effect of caffeine.	Caffeine	48-56	zinc finger protein, FOG family member 1	Homo sapiens	60-63
17404231-7	2007	In the presence of caffeine, Pkd2(-/-) cardiomyocytes exhibited decreased peak fluorescence, a slower rate of rise, and a longer duration of Ca(2+) transients compared with Pkd2(+/+).	Caffeine	19-27	polycystin 2, transient receptor potential cation channel	Mus musculus	29-33
17292432-6	2007	On the other hand, treatment with wortmannin or caffeine, the inhibitors to phosphatidylinositol 3-kinase related kinases (PIKKs), suppressed both NaVO(3)-induced Ser15 phosphorylation and accumulation of p53 protein.	Caffeine	48-56	tumor protein p53	Homo sapiens	205-208
17283049-3	2007	UV transiently increased GSK-3beta activity, and this increase could be blocked by caffeine or by ATR small interfering RNA, indicating ATR-dependent activation of GSK-3beta.	Caffeine	83-91	glycogen synthase kinase 3 beta	Homo sapiens	25-34
17283049-3	2007	UV transiently increased GSK-3beta activity, and this increase could be blocked by caffeine or by ATR small interfering RNA, indicating ATR-dependent activation of GSK-3beta.	Caffeine	83-91	ATR serine/threonine kinase	Homo sapiens	136-139
21591074-0	2007	HPLC determination of caffeine and paraxanthine in urine: An assay for cytochrome P450 1A2 activity.	Caffeine	22-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-90
17322175-7	2007	Expression of RyR2 containing the 24-bp insertion also suppressed intracellular Ca(2+) fluxes following prolonged caffeine exposure (1 mmol/L, 16 hours) that protected cells from apoptosis.	Caffeine	114-122	ryanodine receptor 2	Homo sapiens	14-18
17182611-4	2007	Addition of caffeine to spindle checkpoint-arrested cells induced &gt;40% apoptosis within 5 h. It also caused proteasome-mediated destruction of cyclin B1, a corresponding reduction in cyclin B1/cdk1 activity, and reduction in MPM-2 reactivity.	Caffeine	12-20	cyclin B1	Homo sapiens	146-155
17182611-4	2007	Addition of caffeine to spindle checkpoint-arrested cells induced &gt;40% apoptosis within 5 h. It also caused proteasome-mediated destruction of cyclin B1, a corresponding reduction in cyclin B1/cdk1 activity, and reduction in MPM-2 reactivity.	Caffeine	12-20	cyclin B1	Homo sapiens	186-195
17182611-4	2007	Addition of caffeine to spindle checkpoint-arrested cells induced &gt;40% apoptosis within 5 h. It also caused proteasome-mediated destruction of cyclin B1, a corresponding reduction in cyclin B1/cdk1 activity, and reduction in MPM-2 reactivity.	Caffeine	12-20	cyclin dependent kinase 1	Homo sapiens	196-200
17182611-7	2007	After systematically eliminating all known targets, we have identified p21-activated kinase PAK1, which has an anti-apoptotic function in spindle checkpoint-arrested cells, as a target for caffeine inhibition.	Caffeine	189-197	cyclin dependent kinase inhibitor 1A	Homo sapiens	71-74
17182611-7	2007	After systematically eliminating all known targets, we have identified p21-activated kinase PAK1, which has an anti-apoptotic function in spindle checkpoint-arrested cells, as a target for caffeine inhibition.	Caffeine	189-197	p21 (RAC1) activated kinase 1	Homo sapiens	92-96
17446473-5	2007	For example, potentiating the opening of the SR Ca release channel (ryanodine receptor, RyR) with caffeine produces an immediate increase in the amplitude of the systolic Ca transient.	Caffeine	98-106	ryanodine receptor 1	Homo sapiens	88-91
21591074-6	2007	Specifically, the activity of human P450 1A2, which converts caffeine into paraxanthine, can be investigated by measuring the change in caffeine and paraxanthine concentrations in urine over time following a single dose of caffeine.	Caffeine	61-69	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
21591074-6	2007	Specifically, the activity of human P450 1A2, which converts caffeine into paraxanthine, can be investigated by measuring the change in caffeine and paraxanthine concentrations in urine over time following a single dose of caffeine.	Caffeine	136-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
21591074-6	2007	Specifically, the activity of human P450 1A2, which converts caffeine into paraxanthine, can be investigated by measuring the change in caffeine and paraxanthine concentrations in urine over time following a single dose of caffeine.	Caffeine	136-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
17223552-0	2007	Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells.	Caffeine	0-8	vitamin D receptor	Homo sapiens	19-37
17223552-2	2007	In a clinical study we reported that women with caffeine intakes &gt;300 mg/day had higher bone loss and women with vitamin D receptor (VDR) variant, tt were at a greater risk for this deleterious effect of caffeine.	Caffeine	207-215	vitamin D receptor	Homo sapiens	116-134
17223552-2	2007	In a clinical study we reported that women with caffeine intakes &gt;300 mg/day had higher bone loss and women with vitamin D receptor (VDR) variant, tt were at a greater risk for this deleterious effect of caffeine.	Caffeine	207-215	vitamin D receptor	Homo sapiens	136-139
17223552-6	2007	To understand the molecular mechanism of the role of caffeine in relation to bone, we tested the effect of caffeine on VDR expression and 1,25(OH)(2)D(3) mediated actions in bone.	Caffeine	107-115	vitamin D receptor	Homo sapiens	119-122
17223552-7	2007	We therefore examined the effect of different doses of caffeine (0.2, 0.5, 1.0 and 10mM) on 1,25(OH)(2)D(3) induced VDR protein expression in human osteoblast cells.	Caffeine	55-63	vitamin D receptor	Homo sapiens	116-119
17223552-9	2007	Caffeine dose dependently decreased the 1,25(OH)(2)D(3) induced VDR expression and at concentrations of 1 and 10mM, VDR expression was decreased by about 50-70%, respectively.	Caffeine	0-8	vitamin D receptor	Homo sapiens	64-67
17223552-12	2007	Overall, our results suggest that caffeine affects 1,25(OH)(2)D(3) stimulated VDR protein expression and 1,25(OH)(2)D(3) mediated actions in human osteoblast cells.	Caffeine	34-42	vitamin D receptor	Homo sapiens	78-81
17011540-0	2007	Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.	Caffeine	195-203	N-acetyltransferase 2	Homo sapiens	96-100
17257240-1	2007	The adenosine A2A receptor A2AR facilitates effects of calcitonin gene-related peptide and vasoactive intestinal peptide, two important neuropeptides in migraine pathophysiology, and is the molecular target of caffeine, which is used in migraine treatment.	Caffeine	210-218	adenosine A2a receptor	Homo sapiens	4-26
17257240-1	2007	The adenosine A2A receptor A2AR facilitates effects of calcitonin gene-related peptide and vasoactive intestinal peptide, two important neuropeptides in migraine pathophysiology, and is the molecular target of caffeine, which is used in migraine treatment.	Caffeine	210-218	adenosine A2a receptor	Homo sapiens	27-31
17011540-3	2007	METHODS: NAT2 phenotypes of 38 Caucasian workers were determined using a suitable caffeine test method.	Caffeine	82-90	N-acetyltransferase 2	Homo sapiens	9-13
17132813-8	2007	In vivo, antagonism of adenosine receptors with caffeine abrogated VEGF up-regulation induced by local injection of NECA into the mouse hind limb and produced a 46% reduction of neovascularization in a mouse ischemic hind limb model.	Caffeine	48-56	vascular endothelial growth factor A	Mus musculus	67-71
17096346-5	2007	The BITC-induced p53 phosphorylation was counteracted by caffeine treatment, implying the involvement of an ATM/ataxia telangiectasia and Rad3-related kinase signaling pathway.	Caffeine	57-65	tumor protein p53	Homo sapiens	17-20
17096346-5	2007	The BITC-induced p53 phosphorylation was counteracted by caffeine treatment, implying the involvement of an ATM/ataxia telangiectasia and Rad3-related kinase signaling pathway.	Caffeine	57-65	ATM serine/threonine kinase	Homo sapiens	108-111
17251462-1	2007	PURPOSE: To define the role of molecular interaction between the UV-induced JNK (c-Jun N-terminal kinase) cascade and corneal epithelial cell apoptosis and protection against apoptosis by caffeine.	Caffeine	188-196	mitogen-activated protein kinase 8	Homo sapiens	76-79
17251462-1	2007	PURPOSE: To define the role of molecular interaction between the UV-induced JNK (c-Jun N-terminal kinase) cascade and corneal epithelial cell apoptosis and protection against apoptosis by caffeine.	Caffeine	188-196	mitogen-activated protein kinase 8	Homo sapiens	81-104
17251462-5	2007	RESULTS: UV irradiation-induced apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and MAKK4 (SEK1) upstream from JNK was caffeine sensitive.	Caffeine	133-141	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	50-86
17251462-5	2007	RESULTS: UV irradiation-induced apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and MAKK4 (SEK1) upstream from JNK was caffeine sensitive.	Caffeine	133-141	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	88-92
17251462-5	2007	RESULTS: UV irradiation-induced apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and MAKK4 (SEK1) upstream from JNK was caffeine sensitive.	Caffeine	133-141	mitogen-activated protein kinase kinase 4	Homo sapiens	105-109
17251462-5	2007	RESULTS: UV irradiation-induced apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and MAKK4 (SEK1) upstream from JNK was caffeine sensitive.	Caffeine	133-141	mitogen-activated protein kinase 8	Homo sapiens	125-128
17251462-6	2007	Caffeine (1,3,7-trimethylxanthine), an agent that is one of the most popular additions to food consumed in the world and a potential enhancer of chemotherapy, effectively protected corneal epithelial cells against apoptosis by its specific effect on the JNK cascade.	Caffeine	0-8	mitogen-activated protein kinase 8	Homo sapiens	254-257
17251462-6	2007	Caffeine (1,3,7-trimethylxanthine), an agent that is one of the most popular additions to food consumed in the world and a potential enhancer of chemotherapy, effectively protected corneal epithelial cells against apoptosis by its specific effect on the JNK cascade.	Caffeine	10-33	mitogen-activated protein kinase 8	Homo sapiens	254-257
17251462-11	2007	CONCLUSIONS: UV irradiation stress-induced activation of the ASK1-SEK1-JNK signaling pathway leading to apoptosis is a caffeine-sensitive process, and caffeine, as a multifunctional agent in cells, can specifically interact with the pathway to protect against apoptosis.	Caffeine	119-127	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	61-65
17251462-11	2007	CONCLUSIONS: UV irradiation stress-induced activation of the ASK1-SEK1-JNK signaling pathway leading to apoptosis is a caffeine-sensitive process, and caffeine, as a multifunctional agent in cells, can specifically interact with the pathway to protect against apoptosis.	Caffeine	119-127	mitogen-activated protein kinase kinase 4	Homo sapiens	66-70
17251462-11	2007	CONCLUSIONS: UV irradiation stress-induced activation of the ASK1-SEK1-JNK signaling pathway leading to apoptosis is a caffeine-sensitive process, and caffeine, as a multifunctional agent in cells, can specifically interact with the pathway to protect against apoptosis.	Caffeine	119-127	mitogen-activated protein kinase 8	Homo sapiens	71-74
17251462-11	2007	CONCLUSIONS: UV irradiation stress-induced activation of the ASK1-SEK1-JNK signaling pathway leading to apoptosis is a caffeine-sensitive process, and caffeine, as a multifunctional agent in cells, can specifically interact with the pathway to protect against apoptosis.	Caffeine	151-159	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	61-65
17251462-11	2007	CONCLUSIONS: UV irradiation stress-induced activation of the ASK1-SEK1-JNK signaling pathway leading to apoptosis is a caffeine-sensitive process, and caffeine, as a multifunctional agent in cells, can specifically interact with the pathway to protect against apoptosis.	Caffeine	151-159	mitogen-activated protein kinase 8	Homo sapiens	71-74
17092484-11	2006	Ca(2+) imaging experiments using Fluo-4-AM showed atypical caffeine responses in myotubes expressing D4907A and RYR1-TM characterized by either a lack of or slower activation and faster inactivation of Ca(2+) transients.	Caffeine	59-67	ryanodine receptor 1	Homo sapiens	112-116
17139484-11	2007	The amounts of EGCG and caffeine in the tested green tea tincture were each approximately 14 mg mL-1.	Caffeine	24-32	L1 cell adhesion molecule	Mus musculus	96-100
17007839-5	2007	Prolonged treatment with caffeine (1 mg/ml) had no effect alone but prevented the Abeta-induced cognitive impairment in both tasks when associated with acute caffeine (30 mg/kg) 30 min treatment before Abeta administration.	Caffeine	25-33	amyloid beta (A4) precursor protein	Mus musculus	82-87
17007839-5	2007	Prolonged treatment with caffeine (1 mg/ml) had no effect alone but prevented the Abeta-induced cognitive impairment in both tasks when associated with acute caffeine (30 mg/kg) 30 min treatment before Abeta administration.	Caffeine	25-33	amyloid beta (A4) precursor protein	Mus musculus	202-207
17007839-5	2007	Prolonged treatment with caffeine (1 mg/ml) had no effect alone but prevented the Abeta-induced cognitive impairment in both tasks when associated with acute caffeine (30 mg/kg) 30 min treatment before Abeta administration.	Caffeine	158-166	amyloid beta (A4) precursor protein	Mus musculus	82-87
17007839-7	2007	This provides the first direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer"s disease.	Caffeine	53-61	amyloid beta (A4) precursor protein	Mus musculus	121-126
17344941-5	2007	Caffeine is a commonly used probe to assess the metabolic activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-78
17344941-5	2007	Caffeine is a commonly used probe to assess the metabolic activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO).	Caffeine	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	80-86
17344941-5	2007	Caffeine is a commonly used probe to assess the metabolic activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO).	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	88-109
17344941-5	2007	Caffeine is a commonly used probe to assess the metabolic activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO).	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	111-115
17093969-6	2007	The RyR agonist caffeine augmented the frequency of Ca(2+) sparks in cells pretreated with and without 2-APB or xestospongin-C.	Caffeine	16-24	ryanodine receptor 1, skeletal muscle	Mus musculus	4-7
17236787-0	2007	Acute caffeine administration decreased NOS and Bcl2 expression in rat skeletal muscles.	Caffeine	6-14	BCL2, apoptosis regulator	Rattus norvegicus	48-52
17236787-3	2007	We studied the hemodynamic and NOS expression of Bax/Bcl2 in skeletal muscle after single Caf administration.	Caffeine	90-93	BCL2 associated X, apoptosis regulator	Rattus norvegicus	49-52
17236787-3	2007	We studied the hemodynamic and NOS expression of Bax/Bcl2 in skeletal muscle after single Caf administration.	Caffeine	90-93	BCL2, apoptosis regulator	Rattus norvegicus	53-57
17519531-5	2007	However, the caffeine-sensitive Ca2+ releasing pathway from sarcoplasmic reticulum was not affected by thiopental.	Caffeine	13-21	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	32-35
16968677-10	2006	Furthermore, caffeine attenuated the frequency of UV-induced mutations in the hprt gene, whereas the frequency of recombination, monitored in this same gene, was enhanced.	Caffeine	13-21	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	78-82
17055069-4	2006	Recent studies have provided evidence that PARP-1 activity can also be modulated by several endogenous factors, including various kinases, purines and caffeine metabolites.	Caffeine	151-159	poly(ADP-ribose) polymerase 1	Homo sapiens	43-49
17055161-0	2006	Caffeine treatment regulates neuropeptide S system expression in the rat brain.	Caffeine	0-8	neuropeptide S	Rattus norvegicus	29-43
17055161-4	2006	Here, we examined the effect of acute and chronic caffeine treatment on the expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus and brainstem of rats by using real-time PCR.	Caffeine	50-58	neuropeptide S	Rattus norvegicus	90-104
17172433-7	2006	Caffeine, an ATM/ataxia telangiectasia-rad3-related inhibitor, reversed gallic acid-caused ATM and H2A.X phosphorylation and cell cycle arrest, supporting the role of ATM pathway in gallic acid-induced cell cycle arrest.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	13-16
17172433-7	2006	Caffeine, an ATM/ataxia telangiectasia-rad3-related inhibitor, reversed gallic acid-caused ATM and H2A.X phosphorylation and cell cycle arrest, supporting the role of ATM pathway in gallic acid-induced cell cycle arrest.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	91-94
17172433-7	2006	Caffeine, an ATM/ataxia telangiectasia-rad3-related inhibitor, reversed gallic acid-caused ATM and H2A.X phosphorylation and cell cycle arrest, supporting the role of ATM pathway in gallic acid-induced cell cycle arrest.	Caffeine	0-8	H2A.X variant histone	Homo sapiens	99-104
17172433-7	2006	Caffeine, an ATM/ataxia telangiectasia-rad3-related inhibitor, reversed gallic acid-caused ATM and H2A.X phosphorylation and cell cycle arrest, supporting the role of ATM pathway in gallic acid-induced cell cycle arrest.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	91-94
17065585-7	2006	Formula feeding appears to accelerate maturation of caffeine and DM metabolism by increasing the activity of CYP1A2 and CYP3A4, respectively.	Caffeine	52-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
17164694-1	2006	CYP1A2 is involved in the metabolism of both caffeine and propafenone, a class Ic antiarrhythmic agent.	Caffeine	45-53	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
17164694-13	2006	Our results suggest that propafenone causes significant inhibition of CYP1A2 activity leading to a decrease in the clearance of caffeine.	Caffeine	128-136	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
17164694-14	2006	Caffeine has intrinsic proarrhythmic effects; thus, its coadministration with an antiarrhythmic agent such as propafenone should be used with caution, especially in patients with poor CYP2D6 activity.	Caffeine	0-8	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	184-190
17145898-9	2006	Polyphenon E and caffeine treatment inhibited cell proliferation (by 57% and 50%, respectively) in adenocarcinomas, enhanced apoptosis in adenocarcinomas (by 2.6- and 4-fold, respectively) and adenomas (both by 2.5-fold), and lowered levels of c-Jun and extracellular signal-regulated kinase (Erk) 1/2 phosphorylation.	Caffeine	17-25	jun proto-oncogene	Mus musculus	244-249
17145898-9	2006	Polyphenon E and caffeine treatment inhibited cell proliferation (by 57% and 50%, respectively) in adenocarcinomas, enhanced apoptosis in adenocarcinomas (by 2.6- and 4-fold, respectively) and adenomas (both by 2.5-fold), and lowered levels of c-Jun and extracellular signal-regulated kinase (Erk) 1/2 phosphorylation.	Caffeine	17-25	mitogen-activated protein kinase 3	Mus musculus	254-301
16945924-4	2006	Here we show that azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.	Caffeine	124-132	ryanodine receptor 1	Homo sapiens	116-120
17026965-4	2006	In this study, we measured the effect of two ATM/ATR inhibitors caffeine and pentoxifylline on the correction efficiency in SSO-mediated gene repair.	Caffeine	64-72	ATM serine/threonine kinase	Homo sapiens	45-48
17026965-4	2006	In this study, we measured the effect of two ATM/ATR inhibitors caffeine and pentoxifylline on the correction efficiency in SSO-mediated gene repair.	Caffeine	64-72	ATR serine/threonine kinase	Homo sapiens	49-52
16938404-6	2006	In both behaviorally-tested and aged Tg mice, long-term caffeine administration resulted in lower hippocampal beta-amyloid (Abeta) levels.	Caffeine	56-64	amyloid beta (A4) precursor protein	Mus musculus	124-129
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	79-87	presenilin 1	Mus musculus	19-31
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	79-87	presenilin 1	Mus musculus	33-36
17426757-4	2006	We also identified huc(95E) mutants, which are extremely sensitive to caffeine.	Caffeine	70-78	java no jive	Drosophila melanogaster	19-26
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	79-87	beta-site APP cleaving enzyme 1	Mus musculus	58-62
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	79-87	amyloid beta (A4) precursor protein	Mus musculus	126-131
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	168-176	presenilin 1	Mus musculus	19-31
16938404-7	2006	Expression of both Presenilin 1 (PS1) and beta-secretase (BACE) was reduced in caffeine-treated Tg mice, indicating decreased Abeta production as a likely mechanism of caffeine"s cognitive protection.	Caffeine	168-176	beta-site APP cleaving enzyme 1	Mus musculus	58-62
16938404-8	2006	The ability of caffeine to reduce Abeta production was confirmed in SweAPP N2a neuronal cultures, wherein concentration-dependent decreases in both Abeta1-40 and Abeta1-42 were observed.	Caffeine	15-23	amyloid beta (A4) precursor protein	Mus musculus	34-39
17016495-4	2006	EXPERIMENTAL APPROACH: The activity of glycogen phosphorylase was modulated using the allosteric effectors glucose or caffeine to promote the less active T state, and AMP to promote the more active R state.	Caffeine	118-126	glycogen phosphorylase L	Rattus norvegicus	39-61
17426757-5	2006	Although huc(95E) is a nonessential gene, mutant imaginal disc cells undergo caffeine-dependent apoptosis, and huc(95E) gene function is required for the viability of the organism when mutant larvae are exposed to levels of caffeine that controls can easily tolerate.	Caffeine	224-232	java no jive	Drosophila melanogaster	9-16
17426757-5	2006	Although huc(95E) is a nonessential gene, mutant imaginal disc cells undergo caffeine-dependent apoptosis, and huc(95E) gene function is required for the viability of the organism when mutant larvae are exposed to levels of caffeine that controls can easily tolerate.	Caffeine	224-232	java no jive	Drosophila melanogaster	111-118
17050719-2	2006	In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP-protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogen-activated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents.	Caffeine	83-91	mitogen-activated protein kinase 3	Homo sapiens	335-341
16923813-0	2006	Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.	Caffeine	0-8	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	113-118
16923813-4	2006	Here we show that caffeine acts as a distinct and novel small molecule inhibitor of TORC1: (i) deleting components specific to TORC1 but not TORC2 renders cells hypersensitive to caffeine; (ii) rapamycin and caffeine display remarkably similar effects on global gene expression; and (iii) mutations were isolated in Tor1p, a component specific to TORC1, that confers significant caffeine resistance both in vivo and in vitro.	Caffeine	18-26	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	316-321
16923813-6	2006	Biochemical and genetic analyses of these mutant forms of Tor1p support a model wherein functional interactions between the FRB and kinase domains, as well as between the FRB domain and the TORC1 component Kog1p, regulate TOR activity as well as contribute to the mechanism of caffeine resistance.	Caffeine	277-285	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	58-63
17051818-6	2006	The caffeine breath test, a monitor of CYP1A2 activity, was conducted, and its results were compared to serum levels of chemicals and the subjects" medical history.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
16917819-0	2006	Differential c-Fos immunoreactivity in arousal-promoting cell groups following systemic administration of caffeine in rats.	Caffeine	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
16917819-2	2006	By using c-Fos immunohistochemistry as a marker of neuronal activation, we recently showed that stimulant doses of caffeine activate arousal-promoting hypothalamic orexin (hypocretin) neurons.	Caffeine	115-123	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	9-14
16917819-2	2006	By using c-Fos immunohistochemistry as a marker of neuronal activation, we recently showed that stimulant doses of caffeine activate arousal-promoting hypothalamic orexin (hypocretin) neurons.	Caffeine	115-123	hypocretin neuropeptide precursor	Rattus norvegicus	164-170
16917819-6	2006	The three doses of caffeine induced distinct dose-related patterns of c-Fos immunoreactivity in several arousal-promoting areas, including orexin neurons and adjacent neurons containing neither orexin nor melanin-concentrating hormone; tuberomammillary histaminergic neurons; locus coeruleus noradrenergic neurons; noncholinergic basal forebrain neurons that do not contain parvalbumin; and nondopaminergic neurons in the ventral tegmental area.	Caffeine	19-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-75
16917819-6	2006	The three doses of caffeine induced distinct dose-related patterns of c-Fos immunoreactivity in several arousal-promoting areas, including orexin neurons and adjacent neurons containing neither orexin nor melanin-concentrating hormone; tuberomammillary histaminergic neurons; locus coeruleus noradrenergic neurons; noncholinergic basal forebrain neurons that do not contain parvalbumin; and nondopaminergic neurons in the ventral tegmental area.	Caffeine	19-27	hypocretin neuropeptide precursor	Rattus norvegicus	139-145
16917819-6	2006	The three doses of caffeine induced distinct dose-related patterns of c-Fos immunoreactivity in several arousal-promoting areas, including orexin neurons and adjacent neurons containing neither orexin nor melanin-concentrating hormone; tuberomammillary histaminergic neurons; locus coeruleus noradrenergic neurons; noncholinergic basal forebrain neurons that do not contain parvalbumin; and nondopaminergic neurons in the ventral tegmental area.	Caffeine	19-27	hypocretin neuropeptide precursor	Rattus norvegicus	194-200
16917819-6	2006	The three doses of caffeine induced distinct dose-related patterns of c-Fos immunoreactivity in several arousal-promoting areas, including orexin neurons and adjacent neurons containing neither orexin nor melanin-concentrating hormone; tuberomammillary histaminergic neurons; locus coeruleus noradrenergic neurons; noncholinergic basal forebrain neurons that do not contain parvalbumin; and nondopaminergic neurons in the ventral tegmental area.	Caffeine	19-27	parvalbumin	Rattus norvegicus	374-385
16917819-9	2006	These results indicate that motor-stimulatory doses of caffeine induce a remarkably restricted pattern of c-Fos expression in the arousal-promoting system and suggest that this specific neuronal activation may be involved in the behavioral arousal by caffeine.	Caffeine	55-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
16917819-9	2006	These results indicate that motor-stimulatory doses of caffeine induce a remarkably restricted pattern of c-Fos expression in the arousal-promoting system and suggest that this specific neuronal activation may be involved in the behavioral arousal by caffeine.	Caffeine	251-259	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
17040215-2	2006	However, caffeine inhibits the metabolism of melatonin by CYP1A2 and dietary caffeine could be a potential confounder for the measurement of CYP1A2 activity with melatonin.	Caffeine	9-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-64
17040215-2	2006	However, caffeine inhibits the metabolism of melatonin by CYP1A2 and dietary caffeine could be a potential confounder for the measurement of CYP1A2 activity with melatonin.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	141-147
17040215-3	2006	We undertook a 3-phase cross-over study in 12 healthy volunteers to examine whether caffeine (200 mg single dose), taken 12 hr or 24 hr prior to melatonin intake, would affect the results of CYP1A2 phenotyping results as assessed by a spot sample melatonin concentration 1.5 hr after intake of 6 mg of melatonin orally.	Caffeine	84-92	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	191-197
17040215-7	2006	Abstinence from caffeine for 24 hr prior to melatonin intake should be enough to overcome the possible confounding effect of caffeine on the CYP1A2 phenotyping with melatonin.	Caffeine	16-24	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	141-147
17040215-7	2006	Abstinence from caffeine for 24 hr prior to melatonin intake should be enough to overcome the possible confounding effect of caffeine on the CYP1A2 phenotyping with melatonin.	Caffeine	125-133	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	141-147
16552410-11	2006	CONCLUSION: A dietary supplement containing a low potency ephedra/caffeine mixture appeared safe and effective in causing loss of weight and body fat, and improving several metabolic parameters, including insulin sensitivity and lipid profiles when tested under physician supervision.	Caffeine	66-74	insulin	Homo sapiens	205-212
16846843-10	2006	Caffeine also had an early effect on the increase in renal TK secretion.	Caffeine	0-8	kallikrein 1	Homo sapiens	59-61
16930926-6	2006	These results indicate that caffeine can impact neuronal functions through the modification of [Ca2+]i.	Caffeine	28-36	carbonic anhydrase 2	Mus musculus	96-99
16908529-6	2006	Inhibition of ATR activity via caffeine, a dominant-negative kinase-dead mutant, or RNA interference led to the attenuation of UV-induced DNA-PKcs phosphorylation.	Caffeine	31-39	ATR serine/threonine kinase	Homo sapiens	14-17
16908529-6	2006	Inhibition of ATR activity via caffeine, a dominant-negative kinase-dead mutant, or RNA interference led to the attenuation of UV-induced DNA-PKcs phosphorylation.	Caffeine	31-39	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	138-146
16870158-9	2006	Concluding, caffeine metabolites are inhibitors of PARP-1 and the major caffeine metabolite 1,7-dimethylxanthine has significant PARP-1 inhibiting activity in cultured epithelial and endothelial cells at physiological concentrations.	Caffeine	12-20	poly(ADP-ribose) polymerase 1	Homo sapiens	51-57
16870158-9	2006	Concluding, caffeine metabolites are inhibitors of PARP-1 and the major caffeine metabolite 1,7-dimethylxanthine has significant PARP-1 inhibiting activity in cultured epithelial and endothelial cells at physiological concentrations.	Caffeine	72-80	poly(ADP-ribose) polymerase 1	Homo sapiens	129-135
16889759-9	2006	Following administration of MDMA to rats, there was a persistent decrease in the number of serotonin transporter sites in the cortex, striatum and hippocampus, which was potentiated by caffeine co-treatment.	Caffeine	185-193	solute carrier family 6 member 4	Rattus norvegicus	91-112
16823803-1	2006	Caffeine is an adenosine receptor A1 and A2A receptor antagonist and a putative functional genetic variant of the A2A receptor (2592C > Tins) mediates caffeine-induced anxiety.	Caffeine	0-8	adenosine A1 receptor	Homo sapiens	15-36
16969115-7	2006	Checkpoint inhibition with caffeine could rescue PCNA disassembly only partially, pointing to additional effects due to CDK2 inhibition and the presence of replication stress.	Caffeine	27-35	proliferating cell nuclear antigen	Homo sapiens	49-53
16930926-0	2006	Modulation of neuronal [Ca2+]i by caffeine is altered with aging.	Caffeine	34-42	carbonic anhydrase 2	Mus musculus	24-27
16930926-5	2006	Caffeine enhanced the peak [Ca2+]i as compared to control solution in young mice (control: 325+/-8 nM, caffeine: 402+/-10 nM), but had no effect on the peak [Ca2+]i in old mice (control: 222+/-6 nM, caffeine: 223+/-7 nM).	Caffeine	0-8	carbonic anhydrase 2	Mus musculus	28-31
16794026-3	2006	The present study, therefore, investigated the effect of caffeine supplementation, a known stimulator of sympathetic activity, on the extracellular (e)HSP72 response to prolonged exercise.	Caffeine	57-65	heat shock protein family A (Hsp70) member 1A	Homo sapiens	151-156
16950368-8	2006	Expression of the cTnI-G203S mutation in neonatal cardiomyocytes resulted in a significant increase in myocyte volume, and reduced interactions with both troponins T and C. Ca2+ cycling was abnormal in adult cardiomyocytes extracted from cTnI-G203S mice, with a prolonged decay constant in Ca2+ transients and a reduced decay constant in response to caffeine treatment.	Caffeine	350-358	troponin I, cardiac 3	Mus musculus	18-22
16870158-4	2006	In this study the PARP-1 inhibiting capacity of caffeine and several metabolites as well as other (methyl)xanthines was tested using an ELISA-assay with purified human PARP-1.	Caffeine	48-56	poly(ADP-ribose) polymerase 1	Homo sapiens	18-24
16870158-4	2006	In this study the PARP-1 inhibiting capacity of caffeine and several metabolites as well as other (methyl)xanthines was tested using an ELISA-assay with purified human PARP-1.	Caffeine	48-56	poly(ADP-ribose) polymerase 1	Homo sapiens	168-174
16870158-5	2006	Caffeine itself showed only weak PARP-1 inhibiting activity, whereas the caffeine metabolites 1,7-dimethylxanthine, 3-methylxanthine and 1-methylxanthine, as well as theobromine and theophylline showed significant PARP-1 inhibiting activity.	Caffeine	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	33-39
16979558-4	2006	Here, we show that the gustatory receptor Gr66a is expressed in the dendrites of Drosophila gustatory receptor neurons and is essential for the caffeine response.	Caffeine	144-152	Gustatory receptor 66a	Drosophila melanogaster	42-47
16979558-5	2006	In a behavioral assay, the aversion to caffeine was specifically disrupted in flies missing Gr66a.	Caffeine	39-47	Gustatory receptor 66a	Drosophila melanogaster	92-97
16979558-8	2006	Given that theobromine and caffeine inhibit PDEs with equal potencies , these data further support the role of Gr66a rather than a PDE in mediating the caffeine response.	Caffeine	27-35	Gustatory receptor 66a	Drosophila melanogaster	111-116
16979558-8	2006	Given that theobromine and caffeine inhibit PDEs with equal potencies , these data further support the role of Gr66a rather than a PDE in mediating the caffeine response.	Caffeine	152-160	Gustatory receptor 66a	Drosophila melanogaster	111-116
16979558-9	2006	Gr66a is the first gustatory receptor shown to be essential for caffeine-induced behavior and activity of gustatory receptor cells in vivo.	Caffeine	64-72	Gustatory receptor 66a	Drosophila melanogaster	0-5
16603686-8	2006	In contrast, caffeine (10 microM), an RyR channel activator, increased mean transient KCa current frequency but did not alter Ca2+ spark-KCa channel coupling.	Caffeine	13-21	ryanodine receptor 2	Homo sapiens	38-41
16603686-8	2006	In contrast, caffeine (10 microM), an RyR channel activator, increased mean transient KCa current frequency but did not alter Ca2+ spark-KCa channel coupling.	Caffeine	13-21	casein kappa	Homo sapiens	86-89
16846843-11	2006	K(+)-induced increases in renal TK secretion was demonstrated even after treatment with ryanodine or depletion of caffeine-sensitive intracellular Ca(2+) by thapsigargin.	Caffeine	114-122	kallikrein 1	Homo sapiens	32-34
16540173-4	2006	For instance studies indicate that caffeine and its major metabolite paraxanthine suppress neutrophil and monocyte chemotaxis, and also suppress production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha from human blood.	Caffeine	35-43	tumor necrosis factor	Homo sapiens	189-223
16741947-5	2006	However, when ATM is inhibited by caffeine, ATR activation is markedly enhanced.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	14-17
16741947-5	2006	However, when ATM is inhibited by caffeine, ATR activation is markedly enhanced.	Caffeine	34-42	ATR serine/threonine kinase	Homo sapiens	44-47
16741947-6	2006	Total Chk2 and Chk2 Thr68 are also hyperphosphorylated in the presence of caffeine.	Caffeine	74-82	checkpoint kinase 2	Homo sapiens	6-10
16741947-6	2006	Total Chk2 and Chk2 Thr68 are also hyperphosphorylated in the presence of caffeine.	Caffeine	74-82	checkpoint kinase 2	Homo sapiens	15-19
16741947-7	2006	Both ATM+/+ and ATM-/- cells display normal ATR activation in response to UV radiation-induced DNA damage, which is caffeine sensitive.	Caffeine	116-124	ATM serine/threonine kinase	Homo sapiens	5-8
16741947-7	2006	Both ATM+/+ and ATM-/- cells display normal ATR activation in response to UV radiation-induced DNA damage, which is caffeine sensitive.	Caffeine	116-124	ATM serine/threonine kinase	Homo sapiens	16-19
16741947-7	2006	Both ATM+/+ and ATM-/- cells display normal ATR activation in response to UV radiation-induced DNA damage, which is caffeine sensitive.	Caffeine	116-124	ATR serine/threonine kinase	Homo sapiens	44-47
16925551-4	2006	We also showed that the caffeine-induced phosphorylation of Mpk1p was accompanied by a negligible activation of its main downstream target, the Rlm1p transcription factor.	Caffeine	24-32	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	60-65
16925551-6	2006	Additionally, the transcriptional programme elicited by caffeine resembled that of rapamycin, a potent inhibitor of the TOR1/2 kinases.	Caffeine	56-64	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	120-124
16925551-7	2006	Consistent with this analysis, we found that the caffeine-induced phosphorylation of Mpk1p was lost in a tor1Delta mutant.	Caffeine	49-57	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	85-90
16925551-8	2006	Moreover, a tor1Delta mutant was, like mutants defective in components of the Pkc1p-Mpk1p cascade, highly sensitive to caffeine.	Caffeine	119-127	protein kinase C	Saccharomyces cerevisiae S288C	78-83
16925551-8	2006	Moreover, a tor1Delta mutant was, like mutants defective in components of the Pkc1p-Mpk1p cascade, highly sensitive to caffeine.	Caffeine	119-127	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	84-89
16925551-9	2006	However, the hypersensitivity of a tor1 null mutant to this drug was rescued neither by sorbitol nor by adenine, which was found to outcompete caffeine effects specially on mutants in the PKC pathway.	Caffeine	143-151	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	35-39
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	65-73	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	38-42
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	65-73	protein kinase C	Saccharomyces cerevisiae S288C	119-124
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	65-73	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	125-130
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	65-73	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	222-227
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	153-161	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	38-42
16925551-10	2006	Altogether, these data indicated that Tor1 kinase is a target of caffeine, whose inhibition incidentally activates the Pkc1p-Mpk1p cascade, and that the caffeine-dependent phenotypes are largely dependent on inhibition of Tor1p-regulated cellular functions.	Caffeine	153-161	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	222-227
16925551-11	2006	Finally, we found that caffeine provoked, in a Rom2p-dependent manner, a transient drop in intracellular levels of cAMP, that was followed by change in expression of genes implicated in Ras/cAMP pathway.	Caffeine	23-31	Rho family guanine nucleotide exchange factor ROM2	Saccharomyces cerevisiae S288C	47-52
16540173-5	2006	Caffeine has also been reported to suppress human lymphocyte function as indicated by reduced T-cell proliferation and impaired production of Th1 (interleukin [IL]-2 and interferon [IFN]-gamma), Th2 (IL-4, IL-5) and Th3 (IL-10) cytokines.	Caffeine	0-8	negative elongation factor complex member C/D	Homo sapiens	142-145
16540173-5	2006	Caffeine has also been reported to suppress human lymphocyte function as indicated by reduced T-cell proliferation and impaired production of Th1 (interleukin [IL]-2 and interferon [IFN]-gamma), Th2 (IL-4, IL-5) and Th3 (IL-10) cytokines.	Caffeine	0-8	interleukin 4	Homo sapiens	200-204
16540173-5	2006	Caffeine has also been reported to suppress human lymphocyte function as indicated by reduced T-cell proliferation and impaired production of Th1 (interleukin [IL]-2 and interferon [IFN]-gamma), Th2 (IL-4, IL-5) and Th3 (IL-10) cytokines.	Caffeine	0-8	interleukin 5	Homo sapiens	206-210
16540173-5	2006	Caffeine has also been reported to suppress human lymphocyte function as indicated by reduced T-cell proliferation and impaired production of Th1 (interleukin [IL]-2 and interferon [IFN]-gamma), Th2 (IL-4, IL-5) and Th3 (IL-10) cytokines.	Caffeine	0-8	interleukin 10	Homo sapiens	221-226
16740635-5	2006	We show that caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors.	Caffeine	13-21	erb-b2 receptor tyrosine kinase 4	Homo sapiens	165-170
16873551-4	2006	Ventricular tachycardia (VT) was observed after caffeine and epinephrine injection in RyR2(R176Q/+), but not in WT, mice.	Caffeine	48-56	ryanodine receptor 2, cardiac	Mus musculus	86-90
16841221-1	2006	BACKGROUND AND AIMS: Systemic caffeine clearance is considered the gold standard for phenotyping cytochrome P450 1A2 in epidemiological studies, and has been recommended for the non-invasive assessment of liver function in chronic liver disease.	Caffeine	30-38	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	97-116
16886964-9	2006	RESULTS: Caffeine significantly increased the concentration of plasma epinephrine (by 42%, 39%, and 49%), serum-free fatty acids (by 53%, 44%, and 50%), and plasma lactate (by 46%, 36%, and 48%), and insulin resistance (homeostasis model assessment-IR) (by 21%, 26%, and 23%) during rest, after 5 min of cycling, and at exhaustion.	Caffeine	9-17	insulin	Homo sapiens	200-207
16886964-12	2006	CONCLUSIONS: Caffeine treatment increased epinephrine, fatty acids, lactate and norepinephrine at different times during test session and led to insulin-resistance.	Caffeine	13-21	insulin	Homo sapiens	145-152
16868026-8	2006	In addition, we found that caffeine and the poly(ADP-ribose) polymerase (PARP) inhibitor NU1027 enhanced UV-induced recruitment of ssDNA to PML-NBs.	Caffeine	27-35	PML nuclear body scaffold	Homo sapiens	140-143
16782969-1	2006	BACKGROUND: Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-30
16713132-0	2006	Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture.	Caffeine	89-97	Cytochrome P450-6a2	Drosophila melanogaster	40-46
16713132-0	2006	Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture.	Caffeine	89-97	Cytochrome P450-6a8	Drosophila melanogaster	51-57
16713132-1	2006	To examine whether caffeine, the most widely used xenobiotic compound, would induce insect cytochrome P450 or CYP gene expression, upstream DNA fragments of Cyp6a2 (0.12, 0.26, 0.52 and 0.98-kb) and Cyp6a8 (0.06, 0.1, 0.2, 0.5 and 0.8-kb) genes of Drosophila melanogaster were individually fused to the firefly luciferase (luc) reporter gene.	Caffeine	19-27	disembodied	Drosophila melanogaster	110-113
16713132-1	2006	To examine whether caffeine, the most widely used xenobiotic compound, would induce insect cytochrome P450 or CYP gene expression, upstream DNA fragments of Cyp6a2 (0.12, 0.26, 0.52 and 0.98-kb) and Cyp6a8 (0.06, 0.1, 0.2, 0.5 and 0.8-kb) genes of Drosophila melanogaster were individually fused to the firefly luciferase (luc) reporter gene.	Caffeine	19-27	Cytochrome P450-6a2	Drosophila melanogaster	157-163
16713132-5	2006	Endogenous Cyp6a8 and Cyp6a2 genes in these flies also showed caffeine-induced expression.	Caffeine	62-70	Cytochrome P450-6a8	Drosophila melanogaster	11-17
16713132-5	2006	Endogenous Cyp6a8 and Cyp6a2 genes in these flies also showed caffeine-induced expression.	Caffeine	62-70	Cytochrome P450-6a2	Drosophila melanogaster	22-28
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Cytochrome P450-6a2	Drosophila melanogaster	128-134
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Cytochrome P450-6a8	Drosophila melanogaster	139-145
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Jun-related antigen	Drosophila melanogaster	194-213
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Jun-related antigen	Drosophila melanogaster	215-218
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Cyclic-AMP response element binding protein A	Drosophila melanogaster	224-267
16713132-11	2006	Caffeine-responsive sequences are not clustered at one place; they appear to be dispersed in -983/-126 and -761/-109 regions of Cyp6a2 and Cyp6a8 genes which also contain many binding sites for activator protein 1 (AP1) and cyclic AMP response element binding protein (CRE-BP).	Caffeine	0-8	Cyclic-AMP response element binding protein A	Drosophila melanogaster	269-275
16782969-1	2006	BACKGROUND: Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	32-38
16782969-1	2006	BACKGROUND: Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine.	Caffeine	110-118	N-acetyltransferase 2	Homo sapiens	44-65
16782969-1	2006	BACKGROUND: Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) are key enzymes in the metabolism of caffeine.	Caffeine	110-118	N-acetyltransferase 2	Homo sapiens	67-71
16782969-3	2006	Gluthatione S-transferase alpha1 (GSTA1) may also be active in the metabolism of caffeine as it conjugates glutathione to aromatic amines.	Caffeine	81-89	glutathione S-transferase alpha 1	Homo sapiens	0-32
16782969-3	2006	Gluthatione S-transferase alpha1 (GSTA1) may also be active in the metabolism of caffeine as it conjugates glutathione to aromatic amines.	Caffeine	81-89	glutathione S-transferase alpha 1	Homo sapiens	34-39
16771831-0	2006	Potentiation of amphetamine-mediated responses in caffeine-sensitized rats involves modifications in A2A receptors and zif-268 mRNAs in striatal neurons.	Caffeine	50-58	early growth response 1	Rattus norvegicus	119-126
16771831-2	2006	In order to evaluate the possible mechanisms at the basis of these effects, modifications in A(2A) receptor and zif-268 mRNAs were evaluated in rats subchronically treated with caffeine (15 mg/kg i.p.)	Caffeine	177-185	early growth response 1	Rattus norvegicus	112-119
16771831-5	2006	Results showed that the sensitized motor response to caffeine was associated with a decrease of adenosine A(2A) receptor and zif-268 mRNA levels in the striatum and nucleus accumbens, whereas cross-sensitization to amphetamine was linked to a more pronounced increase of zif-268 mRNA levels in the striatum, but not in the nucleus accumbens.	Caffeine	53-61	adenosine A2a receptor	Rattus norvegicus	96-120
16771831-5	2006	Results showed that the sensitized motor response to caffeine was associated with a decrease of adenosine A(2A) receptor and zif-268 mRNA levels in the striatum and nucleus accumbens, whereas cross-sensitization to amphetamine was linked to a more pronounced increase of zif-268 mRNA levels in the striatum, but not in the nucleus accumbens.	Caffeine	53-61	early growth response 1	Rattus norvegicus	125-132
16771831-5	2006	Results showed that the sensitized motor response to caffeine was associated with a decrease of adenosine A(2A) receptor and zif-268 mRNA levels in the striatum and nucleus accumbens, whereas cross-sensitization to amphetamine was linked to a more pronounced increase of zif-268 mRNA levels in the striatum, but not in the nucleus accumbens.	Caffeine	53-61	early growth response 1	Rattus norvegicus	271-278
16771831-6	2006	Single-cell analysis showed that zif-268 mRNA modifications occurred in Enk(+) striatopallidal neurons after acute or subchronic treatment with caffeine and in Enk(-) striatonigral neurons after acute amphetamine administration.	Caffeine	144-152	early growth response 1	Rattus norvegicus	33-40
16771831-6	2006	Single-cell analysis showed that zif-268 mRNA modifications occurred in Enk(+) striatopallidal neurons after acute or subchronic treatment with caffeine and in Enk(-) striatonigral neurons after acute amphetamine administration.	Caffeine	144-152	proenkephalin	Rattus norvegicus	72-75
16867169-4	2006	In detail these selective substrates were caffeine (CYP1A2), coumarin (CYP2A6), tolbutamide (CYP2C9), S-(+)-mephenytoin (CYP2C19), dextromethorphane (CYP2D6), chlorzoxazone (CYP2E1) and testosterone (CYP3A4).	Caffeine	42-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58
16889681-6	2006	Moreover, chronic (48 h) exposure of cells to caffeine (1 microM) stimulated and chronic exposure to xanthohumol and iso-xanthohumol (1 and 0.1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA.	Caffeine	46-54	solute carrier family 19 member 2	Homo sapiens	285-292
16889681-6	2006	Moreover, chronic (48 h) exposure of cells to caffeine (1 microM) stimulated and chronic exposure to xanthohumol and iso-xanthohumol (1 and 0.1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA.	Caffeine	46-54	solute carrier family 6 member 4	Homo sapiens	296-301
16675719-7	2006	CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle.	Caffeine	47-55	fibrinogen beta chain	Homo sapiens	108-118
16678258-4	2006	In mouse duodenum myocytes expressing RYR2 subtype and both spliced and non-spliced RYR3 isoforms, RYR2 and non-spliced RYR3 were activated by caffeine whereas the spliced RYR3 was not.	Caffeine	143-151	ryanodine receptor 2, cardiac	Mus musculus	38-42
16678258-4	2006	In mouse duodenum myocytes expressing RYR2 subtype and both spliced and non-spliced RYR3 isoforms, RYR2 and non-spliced RYR3 were activated by caffeine whereas the spliced RYR3 was not.	Caffeine	143-151	ryanodine receptor 3	Mus musculus	84-88
16678258-4	2006	In mouse duodenum myocytes expressing RYR2 subtype and both spliced and non-spliced RYR3 isoforms, RYR2 and non-spliced RYR3 were activated by caffeine whereas the spliced RYR3 was not.	Caffeine	143-151	ryanodine receptor 2, cardiac	Mus musculus	99-103
16678258-4	2006	In mouse duodenum myocytes expressing RYR2 subtype and both spliced and non-spliced RYR3 isoforms, RYR2 and non-spliced RYR3 were activated by caffeine whereas the spliced RYR3 was not.	Caffeine	143-151	ryanodine receptor 3	Mus musculus	120-124
16678258-4	2006	In mouse duodenum myocytes expressing RYR2 subtype and both spliced and non-spliced RYR3 isoforms, RYR2 and non-spliced RYR3 were activated by caffeine whereas the spliced RYR3 was not.	Caffeine	143-151	ryanodine receptor 3	Mus musculus	120-124
16581872-1	2006	In this study, it was shown that adenosine potentiates caffeine-induced Ca2+ release.	Caffeine	55-63	carbonic anhydrase 2	Mustela putorius furo	72-75
16581872-2	2006	It was then proposed that the enhancement of the caffeine-induced Ca2+ release might occur by a direct effect on the ryanodine Ca2+ release channel or on other Ca2+ regulation mechanisms.	Caffeine	49-57	carbonic anhydrase 2	Mustela putorius furo	66-69
16581872-2	2006	It was then proposed that the enhancement of the caffeine-induced Ca2+ release might occur by a direct effect on the ryanodine Ca2+ release channel or on other Ca2+ regulation mechanisms.	Caffeine	49-57	carbonic anhydrase 2	Mustela putorius furo	127-130
16581872-2	2006	It was then proposed that the enhancement of the caffeine-induced Ca2+ release might occur by a direct effect on the ryanodine Ca2+ release channel or on other Ca2+ regulation mechanisms.	Caffeine	49-57	carbonic anhydrase 2	Mustela putorius furo	127-130
16581872-7	2006	Adenosine (1-100 nm) and the specific A2A receptor agonist CGS 21680 (1-50 nm) produced a concentration-dependant potentiation of the caffeine-induced Ca2+ release from saponin-skinned fibres.	Caffeine	134-142	carbonic anhydrase 2	Mustela putorius furo	151-154
16581872-9	2006	In addition, the potentiation of caffeine-induced Ca2+ release by adenosine (50 nm; 15.3 +/- 1.0%; n = 6) and by CGS 21680 (50 nm; 11.2 +/- 0.4%; n = 6) was reduced by the specific A2A receptor antagonist ZM 241385 (50 nm) to 8.0 +/- 1.4 (n = 4) and 5.4 +/- 1.2% (n = 4), respectively.	Caffeine	33-41	carbonic anhydrase 2	Mustela putorius furo	50-53
16777524-11	2006	In high caffeine, the first twitch after quiescence is not larger, twitch relaxation is slower, V(os) is abolished, and the prolonged nonoscillatory afterdepolarization V(ex) is induced, consistent with an impairment of Ca2+ handling by the sarcoplasmic reticulum.	Caffeine	8-16	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	220-223
16405939-5	2006	The subjects were phenotyped for CYP1A2 and NAT2 using urinary caffeine metabolites.	Caffeine	63-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
16405939-5	2006	The subjects were phenotyped for CYP1A2 and NAT2 using urinary caffeine metabolites.	Caffeine	63-71	N-acetyltransferase 2	Homo sapiens	44-48
16428269-6	2006	Furthermore, NPPB significantly reduced caffeine-induced contraction and increases in intracellular Ca(2+) concentration ([Ca(2+)](i)).	Caffeine	40-48	natriuretic peptide B	Homo sapiens	13-17
16754955-3	2006	Using Xenopus laevis egg extracts, we show that these excess Mcm2-7 complexes license additional dormant origins that do not fire during unperturbed S phases because of suppression by a caffeine-sensitive checkpoint pathway.	Caffeine	186-194	minichromosome maintenance complex component 2 L homeolog	Xenopus laevis	61-67
16641310-6	2006	These conflicting findings suggest that cytochrome P-450 1A2 (CYP1A2) metabolic activity may be associated with IUGR, so the ratio of paraxanthine to caffeine was then modeled.	Caffeine	150-158	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
16690369-6	2006	To block the ATR pathway, we treated with 5 microM of caffeine for 1 h before irradiation.	Caffeine	54-62	ATR serine/threonine kinase	Homo sapiens	13-16
16624262-11	2006	These results suggest that the net effect of DPc10 (and CPVT mutations) on RyR2 function in situ is not only to increase the sensitivity to CICR as caffeine does, but also to potentiate Ca(2+) leakage from the SR. As SPCR can trigger delayed after-depolarisations, the decrease in [Ca(2+)] threshold may contribute to arrhythmias in CPVT patients during exercise or stress.	Caffeine	148-156	ryanodine receptor 2	Homo sapiens	75-79
16690369-9	2006	HEK293 cells were pretreated with caffeine, an inhibitor of the ATR.	Caffeine	34-42	ATR serine/threonine kinase	Homo sapiens	64-67
16690369-10	2006	Caffeine decreased menin localization to the chromatin after UV.	Caffeine	0-8	menin 1	Homo sapiens	19-24
16690369-13	2006	Caffeine blocks menin localization to the chromatin after UV-irradiation.	Caffeine	0-8	menin 1	Homo sapiens	16-21
21162246-3	2006	RESULTS: In the absence of external Ca2+ , the sarco-endoplasmic reticulum Ca2+ pump inhibitor thapsigargin (1 micromol/L) and ryanodine receptor (RyR) activator caffeine both transiently elevated [Ca2+]i from (68.32 +/- 3.43) nmol/L to (240.85 +/- 12.65 ) nmol/L, (481.25 +/- 34.77) nmol/L.	Caffeine	162-170	ryanodine receptor 2	Rattus norvegicus	147-150
16455179-5	2006	Investigations of the competitive binding of NOR and CAF with DNA show that at physiological concentrations of NOR (muM) and CAF (mM) the dominant mechanism influencing the affinity of NOR with DNA is the displacement of bound NOR molecules from DNA due to CAF-DNA complexation (i.e. the protector action of Caffeine).	Caffeine	53-56	latexin	Homo sapiens	116-119
16455179-5	2006	Investigations of the competitive binding of NOR and CAF with DNA show that at physiological concentrations of NOR (muM) and CAF (mM) the dominant mechanism influencing the affinity of NOR with DNA is the displacement of bound NOR molecules from DNA due to CAF-DNA complexation (i.e. the protector action of Caffeine).	Caffeine	308-316	latexin	Homo sapiens	116-119
21783666-1	2006	Apart from its own controversial cytogenotoxic effects, caffeine (CAF), one of the most commonly consumed alkaloids worldwide, is found potentiative to and so also protective from the cytogenotoxic effects of numerous chemical and physical mutagens.	Caffeine	56-64	caffeine susceptibility	Mus musculus	66-69
16778712-8	2006	The present study suggests that caffeine slightly induces the metabolism of FLV, probably mediated by CYP1A2.	Caffeine	32-40	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-108
16629903-8	2006	Similarly, no accumulation of Rad51 in the nuclear matrix could be observed after treatment of HeLa cells with the kinase inhibitor caffeine, which reduces formation of Rad51 foci.	Caffeine	132-140	RAD51 recombinase	Homo sapiens	169-174
16339455-7	2006	Capacitation of macaque spermatozoa, by the addition of caffeine and dbcAMP, resulted in a significant increase in ALH, VCL, and beat cross frequency and a significant decrease in total and progressive motility, straight line velocity, straightness, and LIN when compared to incubated spermatozoa, suggesting the expression of hyperactivated motility.	Caffeine	56-64	vinculin	Macaca mulatta	120-123
16690595-1	2006	PURPOSE: To elucidate the relationship between the radiation-induced activation of ataxia telangiectasia mutated (ATM) kinase, G2 arrest and the caffeine-induced radiosensitization.	Caffeine	145-153	ATM serine/threonine kinase	Homo sapiens	114-117
16484216-5	2006	In Ca(2+) imaging experiments, the gain of excitation-contraction coupling and the amplitude of the Ca(2+) release seen after direct RyR1 activation with caffeine was significantly reduced in TRPC3 KD.	Caffeine	154-162	ryanodine receptor 1, skeletal muscle	Mus musculus	133-137
16484216-5	2006	In Ca(2+) imaging experiments, the gain of excitation-contraction coupling and the amplitude of the Ca(2+) release seen after direct RyR1 activation with caffeine was significantly reduced in TRPC3 KD.	Caffeine	154-162	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	192-197
16278075-0	2006	Caffeine modulates P50 auditory sensory gating in healthy subjects.	Caffeine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	19-22
16527250-9	2006	Adenovirus-mediated overexpression of calumenin-2 in C2C12 myotubes led to increased caffeine-induced Ca2+ release, but decreased depolarization-induced Ca2+ release.	Caffeine	85-93	calumenin	Oryctolagus cuniculus	38-47
16516171-1	2006	EEG and motor phenomena elicited by stimulation of sensorimotor cortex were used to study the effects of chronic postnatal administration of caffeine (10 and 20 mg/kg, s.c. from P7 to P11) in rats.	Caffeine	141-149	S100 calcium binding protein A10	Rattus norvegicus	184-187
16516171-4	2006	In contrast, chronic administration of the lower dose of caffeine resulted in a proconvulsant effect expressed as a significant prolongation of spike-and-wave ADs in P12, P18 and P25 groups as well as of the second "limbic" type of ADs (significant only in P12 and P25).	Caffeine	57-65	cyclin-dependent kinase inhibitor 2C	Rattus norvegicus	171-174
16516171-4	2006	In contrast, chronic administration of the lower dose of caffeine resulted in a proconvulsant effect expressed as a significant prolongation of spike-and-wave ADs in P12, P18 and P25 groups as well as of the second "limbic" type of ADs (significant only in P12 and P25).	Caffeine	57-65	lipocalin 2	Rattus norvegicus	179-182
16516171-4	2006	In contrast, chronic administration of the lower dose of caffeine resulted in a proconvulsant effect expressed as a significant prolongation of spike-and-wave ADs in P12, P18 and P25 groups as well as of the second "limbic" type of ADs (significant only in P12 and P25).	Caffeine	57-65	lipocalin 2	Rattus norvegicus	265-268
16371593-9	2006	The results show that caffeine can increase MPF and MAPK activities in ovine oocytes and that this may contribute to an increased reprogramming in NT embryos.	Caffeine	22-30	mesothelin	Homo sapiens	44-47
16690595-8	2006	Caffeine also sensitized both RKO cells and RKO/ATM cells to radiation.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	48-51
16690595-9	2006	The caffeine treatment suppressed the radiation-induced activation of ATM kinase, suppressed the activation of Chk2 kinase and inhibited the accumulation of cells in G2 phase.	Caffeine	4-12	ATM serine/threonine kinase	Homo sapiens	70-73
16690595-10	2006	The activity of cycline B1/Cdc2 kinase increased earlier but decayed rapidly in the presence of caffeine.	Caffeine	96-104	cyclin dependent kinase 1	Homo sapiens	27-31
16690595-12	2006	CONCLUSIONS: Caffeine inhibited the radiation-induced activation of ATM kinase, thereby preventing the accumulation of cells in G2 phase.	Caffeine	13-21	ATM serine/threonine kinase	Homo sapiens	68-71
16481441-7	2006	Furthermore, it is also shown that A1R-A2AR heteromers constitute a unique target for caffeine and that chronic caffeine treatment leads to modifications in the function of the A1R-A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.	Caffeine	86-94	adenosine A2a receptor	Rattus norvegicus	39-43
16597367-4	2006	We have shown that caffeine leads to an increase in specific cellular neutral endopeptidase activity more than theophylline, theobromine or theanine.	Caffeine	19-27	membrane metalloendopeptidase	Homo sapiens	70-91
16597367-5	2006	We have also shown that the combination of epicatechin, epigallocatechin and epigallocatechingallate with caffeine, theobromine or theophylline induced cellular neutral endopeptidase activity.	Caffeine	106-114	membrane metalloendopeptidase	Homo sapiens	161-182
16474151-4	2006	Both parameters were also enhanced upon treatment of HeLa cells with caffeine, a xanthine that, in this cellular context, stimulates ATM activity.	Caffeine	69-77	ATM serine/threonine kinase	Homo sapiens	133-136
16479016-4	2006	Here, we report that the inhibitory effect of OA is abolished by caffeine, an inhibitor of the checkpoint kinases ataxia-telangiectasia mutated protein (ATM) and ataxia-telangiectasia related protein (ATR) but not by depletion of ATM or ATR from the extract.	Caffeine	65-73	ATM serine/threonine kinase L homeolog	Xenopus laevis	153-156
16479016-4	2006	Here, we report that the inhibitory effect of OA is abolished by caffeine, an inhibitor of the checkpoint kinases ataxia-telangiectasia mutated protein (ATM) and ataxia-telangiectasia related protein (ATR) but not by depletion of ATM or ATR from the extract.	Caffeine	65-73	ATR serine/threonine kinase L homeolog	Xenopus laevis	162-199
16479016-4	2006	Here, we report that the inhibitory effect of OA is abolished by caffeine, an inhibitor of the checkpoint kinases ataxia-telangiectasia mutated protein (ATM) and ataxia-telangiectasia related protein (ATR) but not by depletion of ATM or ATR from the extract.	Caffeine	65-73	ATR serine/threonine kinase L homeolog	Xenopus laevis	201-204
16479016-4	2006	Here, we report that the inhibitory effect of OA is abolished by caffeine, an inhibitor of the checkpoint kinases ataxia-telangiectasia mutated protein (ATM) and ataxia-telangiectasia related protein (ATR) but not by depletion of ATM or ATR from the extract.	Caffeine	65-73	ATM serine/threonine kinase L homeolog	Xenopus laevis	230-233
16479016-4	2006	Here, we report that the inhibitory effect of OA is abolished by caffeine, an inhibitor of the checkpoint kinases ataxia-telangiectasia mutated protein (ATM) and ataxia-telangiectasia related protein (ATR) but not by depletion of ATM or ATR from the extract.	Caffeine	65-73	ATR serine/threonine kinase L homeolog	Xenopus laevis	237-240
16479016-5	2006	Furthermore, we demonstrate that double-strand DNA breaks (DSBs) cause inhibition of Cdc45 loading and initiation of DNA replication and that caffeine, as well as immunodepletion of either ATM or ATR, abolishes this inhibition.	Caffeine	142-150	cell division cycle 45 L homeolog	Xenopus laevis	85-90
16331277-8	2006	Inhibition of DNA-damage-induced stress kinases and p21CIP/WAF-1 expression by caffeine abrogated G2 arrest and induced apoptosis of the irradiated cells in a caspase-3-dependent manner.	Caffeine	79-87	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-64
16331277-8	2006	Inhibition of DNA-damage-induced stress kinases and p21CIP/WAF-1 expression by caffeine abrogated G2 arrest and induced apoptosis of the irradiated cells in a caspase-3-dependent manner.	Caffeine	79-87	caspase 3	Homo sapiens	159-168
16331277-9	2006	Inhibition of cell cycle progression by adenoviral expression of the cyclin dependent kinase inhibitor p21CIP/WAF-1 prevented apoptosis upon caffeine treatment indicating that cell cycle progression, that is, G2-release, is required for induction of apoptosis.	Caffeine	141-149	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-115
16489026-7	2006	Moreover, p53 was still stabilized in ataxia telangiectasia cells or in cells treated with caffeine, suggesting that ATM was not a critical determinant.	Caffeine	91-99	tumor protein p53	Homo sapiens	10-13
16522833-2	2006	Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme.	Caffeine	28-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-97
16522833-2	2006	Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme.	Caffeine	28-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	99-105
16522833-3	2006	Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
16522833-3	2006	Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers.	Caffeine	144-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	123-129
16759004-0	2006	[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].	Caffeine	78-86	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	51-57
16481441-7	2006	Furthermore, it is also shown that A1R-A2AR heteromers constitute a unique target for caffeine and that chronic caffeine treatment leads to modifications in the function of the A1R-A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.	Caffeine	112-120	adenosine A2a receptor	Rattus norvegicus	181-185
16481441-7	2006	Furthermore, it is also shown that A1R-A2AR heteromers constitute a unique target for caffeine and that chronic caffeine treatment leads to modifications in the function of the A1R-A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.	Caffeine	112-120	adenosine A2a receptor	Rattus norvegicus	181-185
16321977-12	2006	Analysis of the deletion mutants showed that although mtq1-Delta had only moderate growth defects on nonfermentable carbon sources, the mtq2-Delta had multiple phenotypes, including cold sensitivity and sensitivity to translation fidelity antibiotics paromomycin and geneticin, to high salt and calcium concentrations, to polymyxin B, and to caffeine.	Caffeine	342-350	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	136-140
16247448-6	2006	The demonstration that caffeine treatment can abrogate this G2 arrest, and that the cells go on to die, has implications for overcoming treatment resistance imposed by radiation-induced upregulation of p21CIP/WAF1.	Caffeine	23-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	209-213
16284304-7	2006	In addition, the heterozygous expression of the mutation results in enhanced RyR1 sensitivity to activation by temperature, caffeine, and voltage but not uncompensated sarcoplasmic reticulum calcium leak or store depletion.	Caffeine	124-132	ryanodine receptor 1, skeletal muscle	Mus musculus	77-81
16406087-6	2006	These abnormal Ca2+ signals, which can be inhibited by caffeine, explain how excessive alcohol intake and biliary disease cause acute pancreatitis, an often-fatal human disease in which the pancreas digests itself and its surroundings.	Caffeine	55-63	carbonic anhydrase 2	Homo sapiens	15-18
16227470-8	2006	Further experiments showed caffeine directly blocks hERG in an open state-dependent manner.	Caffeine	27-35	ETS transcription factor ERG	Homo sapiens	52-56
16227470-9	2006	Furthermore, caffeine inhibition is greatly reduced by the pore mutants Y562A and F656A hERG, which disrupt block of most previously tested hERG antagonists.	Caffeine	13-21	ETS transcription factor ERG	Homo sapiens	88-92
16227470-9	2006	Furthermore, caffeine inhibition is greatly reduced by the pore mutants Y562A and F656A hERG, which disrupt block of most previously tested hERG antagonists.	Caffeine	13-21	ETS transcription factor ERG	Homo sapiens	140-144
16227470-10	2006	Thus, caffeine attenuates hERG currents by binding to a drug receptor located within the inner cavity of the channel.	Caffeine	6-14	ETS transcription factor ERG	Homo sapiens	26-30
16227470-12	2006	However, the effects of caffeine have implications for its use in examining calcium-dependent pathways in cellular preparations expressing hERG.	Caffeine	24-32	ETS transcription factor ERG	Homo sapiens	139-143
16227470-6	2006	In this study, we show 5 mM caffeine rapidly and reversibly attenuates hERG currents expressed in human embryonic kidney 293 cells to 61.1 +/- 2.2% of control.	Caffeine	28-36	ETS transcription factor ERG	Homo sapiens	71-75
16227470-7	2006	Caffeine-dependent inhibition of hERG current is not altered by raising cAMP with forskolin, buffering cytosolic calcium with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid, or inhibition of protein kinase C. Thus, the effects of caffeine are unlikely to be mediated by cAMP or intracellular calcium-dependent mechanisms.	Caffeine	0-8	ETS transcription factor ERG	Homo sapiens	33-37
16391865-0	2006	Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.	Caffeine	0-8	cAMP responsive element binding protein 1	Homo sapiens	130-134
16391865-0	2006	Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.	Caffeine	0-8	mitogen-activated protein kinase 3	Homo sapiens	139-145
16407567-9	2006	The BNP effect was blocked by the ryanodine receptor modulators caffeine, ryanodine, and ruthenium red but not by the IP3 receptor antagonists heparin and xestospongin-C.	Caffeine	64-72	natriuretic peptide B	Rattus norvegicus	4-7
16289559-7	2006	The AEDs of phenol and caffeine are bimodal with the C18-bonded columns while they are trimodal and quadrimodal, respectively, with a non-endcapped C30-bonded column.	Caffeine	23-31	Bardet-Biedl syndrome 9	Homo sapiens	53-56
16236444-1	2006	Adenosine A(2A) receptor (A(2A)R) antagonists, including the non-specific adenosine antagonist caffeine, have been proposed as a novel, non-dopaminergic treatment strategy for Parkinson"s disease (PD).	Caffeine	95-103	adenosine A2a receptor	Mus musculus	0-24
16522534-0	2006	Caffeine induces apoptosis of human umbilical vein endothelial cells through the caspase-9 pathway.	Caffeine	0-8	caspase 9	Homo sapiens	81-90
16339485-5	2006	In contrast, after channel activation, the abnormal Ca2+ release via mutant RyR2 was intrinsically linked to altered interdomain interaction that was equivalent with all mutations and exhibited threshold characteristics (caffeine &gt;2.5 mmol/L; Ca2+ &gt;150 nmol/L).	Caffeine	221-229	ryanodine receptor 2	Cricetulus griseus	76-80
16360882-4	2006	Caffeine also increased P300 amplitude in the choice RT task and reduced the integral of the N500 difference wave at most sites when combined with alcohol.	Caffeine	0-8	E1A binding protein p300	Homo sapiens	24-28
16397265-3	2006	Based on clonogenic survival, the three single agents (IR, IUdR, and caffeine) as well as IUdR or caffeine combined with IR are less or equally effective in p53-deficient human tumor cells compared with p53-proficient tumor cells.	Caffeine	69-77	tumor protein p53	Homo sapiens	157-160
16397265-3	2006	Based on clonogenic survival, the three single agents (IR, IUdR, and caffeine) as well as IUdR or caffeine combined with IR are less or equally effective in p53-deficient human tumor cells compared with p53-proficient tumor cells.	Caffeine	98-106	tumor protein p53	Homo sapiens	157-160
16397265-9	2006	Cell cycle analyses also showed a greater abrogation of IR-induced S- and G2-phase arrests by caffeine in p53-deficient cells, particularly when combined with IUdR.	Caffeine	94-102	tumor protein p53	Homo sapiens	106-109
16397265-11	2006	This differential dual mode of radiosensitization by combining IUdR and caffeine-like drugs (e.g., UCN-01) in p53-deficient human tumors may lead to a greater therapeutic gain.	Caffeine	72-80	tumor protein p53	Homo sapiens	110-113
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	caspase 9	Homo sapiens	82-91
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	caspase 3	Homo sapiens	93-102
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	107-111
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	caspase 3	Homo sapiens	241-250
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	caspase 8	Homo sapiens	303-312
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	0-8	caspase 9	Homo sapiens	455-464
16522534-9	2006	Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase-9, caspase-3 and PARP expression in HUVECs at 24-h treatment compared with untreated cultures, whereas 30 microM caffeine significantly increased only caspase-3 expression at 24 h. Caffeine did not affect cleaved caspase-8 expression at 48 h. These results suggest that high concentrations of caffeine inhibit cell growth of HUVECs and induce apoptosis through the caspase-9 pathway.	Caffeine	203-211	caspase 3	Homo sapiens	93-102
16003747-3	2006	NAT2 enzymatic activity phenotype was characterized by measuring urinary caffeine metabolite ratios.	Caffeine	73-81	N-acetyltransferase 2	Homo sapiens	0-4
17206514-3	2006	In the present study, we investigated the effect of luminal Ca(2+) on the response of RYR2 channels reconstituted into a planar lipid membrane to caffeine and Ca(2+) added to the cytosolic side of the channel.	Caffeine	146-154	ryanodine receptor 2	Homo sapiens	86-90
16288776-8	2006	Caffeine-induced Ca2+ release showed increased NCX activity (P&lt;0.025) without changes in total releasable SR Ca2+, suggesting compensatory changes in SERCA2 and pSer16-PLB to maintain SR Ca2+ load.	Caffeine	0-8	solute carrier family 8 member A1	Rattus norvegicus	47-50
16288776-8	2006	Caffeine-induced Ca2+ release showed increased NCX activity (P&lt;0.025) without changes in total releasable SR Ca2+, suggesting compensatory changes in SERCA2 and pSer16-PLB to maintain SR Ca2+ load.	Caffeine	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	153-159
16529557-9	2006	So far, the mechanisms of RyR activation by ATP and caffeine have been described in detail using [3H]-ryanodine binding assays and unitary channel activity recorded in planar lipid bilayers.	Caffeine	52-60	ryanodine receptor 2	Homo sapiens	26-29
16382135-5	2006	The increase in xFA chromatin binding following treatment with MMC is part of a caffeine-sensitive S-phase checkpoint that is controlled by xATR.	Caffeine	80-88	ATR serine/threonine kinase L homeolog	Xenopus laevis	140-144
16491669-3	2006	Research into the effects of coffee on human health is ongoing, but a recent study suggests that coffee and caffeine consumption can reduce the risk of elevated alanine aminotransferase activity in individuals at high risk for liver disease.	Caffeine	108-116	glutamic--pyruvic transaminase	Homo sapiens	161-185
16324916-7	2006	Ephedrine plus caffeine alone reduced LDL CE (-13%), phospholipids (-9%), and apolipoprotein (apo) B (-13%); increased HDL-M LpA-I (HDL containing apoA-I without apoA-II, 28%), CE/TG (23%), and CE/apoA-I (8%) while reducing apoA-II (-10%); and increased HDL-L LpA-I (29%).	Caffeine	15-23	apolipoprotein A1	Homo sapiens	147-153
16324916-7	2006	Ephedrine plus caffeine alone reduced LDL CE (-13%), phospholipids (-9%), and apolipoprotein (apo) B (-13%); increased HDL-M LpA-I (HDL containing apoA-I without apoA-II, 28%), CE/TG (23%), and CE/apoA-I (8%) while reducing apoA-II (-10%); and increased HDL-L LpA-I (29%).	Caffeine	15-23	apolipoprotein A2	Homo sapiens	162-169
16324916-7	2006	Ephedrine plus caffeine alone reduced LDL CE (-13%), phospholipids (-9%), and apolipoprotein (apo) B (-13%); increased HDL-M LpA-I (HDL containing apoA-I without apoA-II, 28%), CE/TG (23%), and CE/apoA-I (8%) while reducing apoA-II (-10%); and increased HDL-L LpA-I (29%).	Caffeine	15-23	apolipoprotein A1	Homo sapiens	162-168
16324916-7	2006	Ephedrine plus caffeine alone reduced LDL CE (-13%), phospholipids (-9%), and apolipoprotein (apo) B (-13%); increased HDL-M LpA-I (HDL containing apoA-I without apoA-II, 28%), CE/TG (23%), and CE/apoA-I (8%) while reducing apoA-II (-10%); and increased HDL-L LpA-I (29%).	Caffeine	15-23	apolipoprotein A2	Homo sapiens	224-231
17169946-7	2006	Recent work in cancer cytogenetics and on the modulation of radiation effects at the chromosome level using changes in gene expression associated with proteins or factors such as caffeine or amifostine treatment during G(2) to M-phase transition, reconfirmed the importance of G(2) chekpoint in determining radiosensitivity and of the cdk1/cyclin-B activity in the conversion of DNA damage into chromatid breaks.	Caffeine	179-187	cyclin dependent kinase 1	Homo sapiens	335-339
16856769-1	2006	Effects of coffee and caffeine on cholesterol, fibrinogen and C-reactive protein.	Caffeine	22-30	C-reactive protein	Homo sapiens	62-80
16856769-7	2006	The literature indicates a strong relationship between boiled, unfiltered coffee consumption and elevated cholesterol levels; however, there is a critical gap in the literature regarding the effects of coffee or caffeine consumption on fibrinogen or CRP, which is an independent predictor of CVD risk.	Caffeine	212-220	fibrinogen beta chain	Homo sapiens	236-246
16856769-7	2006	The literature indicates a strong relationship between boiled, unfiltered coffee consumption and elevated cholesterol levels; however, there is a critical gap in the literature regarding the effects of coffee or caffeine consumption on fibrinogen or CRP, which is an independent predictor of CVD risk.	Caffeine	212-220	C-reactive protein	Homo sapiens	250-253
16135658-0	2005	Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.	Caffeine	13-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
16251211-7	2005	The nuclear localization of ATBF1 was suppressed by treatment with caffeine, an inhibitor of PI(3)K-related kinase activity of ataxa-telangiectasia mutated (ATM) gene product.	Caffeine	67-75	zinc finger homeobox 3	Mus musculus	28-33
16251211-7	2005	The nuclear localization of ATBF1 was suppressed by treatment with caffeine, an inhibitor of PI(3)K-related kinase activity of ataxa-telangiectasia mutated (ATM) gene product.	Caffeine	67-75	ataxia telangiectasia mutated	Mus musculus	127-155
16251211-7	2005	The nuclear localization of ATBF1 was suppressed by treatment with caffeine, an inhibitor of PI(3)K-related kinase activity of ataxa-telangiectasia mutated (ATM) gene product.	Caffeine	67-75	ataxia telangiectasia mutated	Mus musculus	157-160
16141365-7	2005	Caffeine, an inhibitor of CYP1A2 activity and an enhancer of CYP3A activity, decreased APAP hepatotoxicity in wild-type mice.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	26-32
16141365-7	2005	Caffeine, an inhibitor of CYP1A2 activity and an enhancer of CYP3A activity, decreased APAP hepatotoxicity in wild-type mice.	Caffeine	0-8	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	61-66
16205915-5	2005	RESULTS: The pattern of behavioral activation induced by caffeine was better mimicked by CPT than by MSX-3.	Caffeine	57-65	msh homeobox 3	Rattus norvegicus	101-106
16212938-4	2005	Substances that increase the intracellular cyclic AMP-concentration also strengthen the transactivity of the GR and coincubation with caffeine further reinforces this potentiation, indicating that caffeine-mediated enhancement of GR transcriptional function is due to the inhibitory activity of caffeine on the cyclic AMP phosphodiesterase.	Caffeine	197-205	nuclear receptor subfamily 3 group C member 1	Homo sapiens	230-232
16212938-4	2005	Substances that increase the intracellular cyclic AMP-concentration also strengthen the transactivity of the GR and coincubation with caffeine further reinforces this potentiation, indicating that caffeine-mediated enhancement of GR transcriptional function is due to the inhibitory activity of caffeine on the cyclic AMP phosphodiesterase.	Caffeine	197-205	nuclear receptor subfamily 3 group C member 1	Homo sapiens	109-111
16212938-0	2005	Caffeine-mediated enhancement of glucocorticoid receptor activity in human osteoblastic cells.	Caffeine	0-8	nuclear receptor subfamily 3 group C member 1	Homo sapiens	33-56
16212938-2	2005	Since the glucocorticoid receptor (GR) is a major factor in the induction of osteoporosis we analyzed whether caffeine may act via altering GR function.	Caffeine	110-118	nuclear receptor subfamily 3 group C member 1	Homo sapiens	140-142
16212938-4	2005	Substances that increase the intracellular cyclic AMP-concentration also strengthen the transactivity of the GR and coincubation with caffeine further reinforces this potentiation, indicating that caffeine-mediated enhancement of GR transcriptional function is due to the inhibitory activity of caffeine on the cyclic AMP phosphodiesterase.	Caffeine	197-205	nuclear receptor subfamily 3 group C member 1	Homo sapiens	230-232
16212938-3	2005	Applying a reporter gene assay we provide evidence that caffeine drastically amplifies GR transcriptional activity in human osteoblastic cells.	Caffeine	56-64	nuclear receptor subfamily 3 group C member 1	Homo sapiens	87-89
16150793-1	2005	While caffeine impedes insulin-mediated glucose disposal in humans, its effect on endo-genous glucose production (EGP) remains unknown.	Caffeine	6-14	insulin	Homo sapiens	23-30
16212938-4	2005	Substances that increase the intracellular cyclic AMP-concentration also strengthen the transactivity of the GR and coincubation with caffeine further reinforces this potentiation, indicating that caffeine-mediated enhancement of GR transcriptional function is due to the inhibitory activity of caffeine on the cyclic AMP phosphodiesterase.	Caffeine	134-142	nuclear receptor subfamily 3 group C member 1	Homo sapiens	230-232
16212938-4	2005	Substances that increase the intracellular cyclic AMP-concentration also strengthen the transactivity of the GR and coincubation with caffeine further reinforces this potentiation, indicating that caffeine-mediated enhancement of GR transcriptional function is due to the inhibitory activity of caffeine on the cyclic AMP phosphodiesterase.	Caffeine	197-205	nuclear receptor subfamily 3 group C member 1	Homo sapiens	109-111
16240390-3	2005	Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation.	Caffeine	134-142	ryanodine receptor 1, skeletal muscle	Mus musculus	160-163
16061478-9	2005	Interestingly, constitutively activated Akt, which rescues cells from Q209L-induced apoptosis, prevented the decrease in NCX expression, normalized cytosolic Ca(2+) levels and spontaneous Ca(2+) oscillations, shortened caffeine-induced Ca(2+) transients, and prevented loss of the mitochondrial membrane potential.	Caffeine	219-227	AKT serine/threonine kinase 1	Homo sapiens	40-43
16236038-1	2005	BACKGROUND: Coadministration of fluvoxamine impairs the clearance of caffeine and prolongs its elimination half-life, which is attributable to inhibition of CYP1A2 by fluvoxamine.	Caffeine	69-77	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	157-163
16246297-6	2005	The bell-shape Ca(2+)-dependent [(3)H]ryanodine binding curve and its modulation by caffeine and adenylylmethylenediphosphonate (AMPPCP) give further evidence that mRyR functions pharmacologically like RyR1.	Caffeine	84-92	ryanodine receptor 1, skeletal muscle	Mus musculus	164-168
16225762-5	2005	CYP1A2 activity was assayed using high performance liquid chromatography, with caffeine as the CYP1A2 substrate.	Caffeine	79-87	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	95-101
16002556-8	2005	Contrary to EDL fibers, soleus muscle fibers of Sgca-null mice distinctively showed right shift of the pCa-tension (pCa is the negative log of Ca2+ concentration) relationships and reduced sensitivity to caffeine of sarcoplasmic reticulum.	Caffeine	204-212	sarcoglycan, alpha (dystrophin-associated glycoprotein)	Mus musculus	48-52
16014567-7	2005	Tachpyridine-induced cell-cycle arrest was abrogated in cells treated with caffeine, an inhibitor of the ataxia-telangiectasia mutated/ataxia-telangiectasia-mutated and Rad3-related (ATM/ATR) kinases.	Caffeine	75-83	ATR serine/threonine kinase	Homo sapiens	187-190
16240390-3	2005	Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation.	Caffeine	134-142	presenilin 2	Mus musculus	177-180
16225762-5	2005	CYP1A2 activity was assayed using high performance liquid chromatography, with caffeine as the CYP1A2 substrate.	Caffeine	79-87	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
16221767-7	2005	In contrast, a distinct polymorphism of the adenosine A(2A) receptor gene, which was associated with interindividual differences in anxiety symptoms after caffeine intake in healthy volunteers, affects the electroencephalogram during sleep and wakefulness in a non-state-specific manner.	Caffeine	155-163	adenosine A2a receptor	Homo sapiens	44-68
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	ATM serine/threonine kinase	Homo sapiens	125-128
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	ATR serine/threonine kinase	Homo sapiens	129-132
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	ATM serine/threonine kinase	Homo sapiens	194-197
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	ATR serine/threonine kinase	Homo sapiens	198-201
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	checkpoint kinase 1	Homo sapiens	202-208
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	cell division cycle 25C	Homo sapiens	239-245
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	cyclin dependent kinase 1	Homo sapiens	239-243
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	H2A.X variant histone	Homo sapiens	256-261
15975959-0	2005	Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice.	Caffeine	28-36	transformation related protein 53, pseudogene	Mus musculus	81-84
15975959-0	2005	Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice.	Caffeine	28-36	transformation related protein 53, pseudogene	Mus musculus	106-109
15975959-3	2005	Sequencing analysis of the p53 gene (exons 3 to 9) detected 88, 82 or 39 point mutations in 67, 70 or 29 patches from water, caffeine or tea treated mice, respectively.	Caffeine	125-133	transformation related protein 53, pseudogene	Mus musculus	27-30
15975959-10	2005	In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations.	Caffeine	40-48	transformation related protein 53, pseudogene	Mus musculus	129-132
15975959-10	2005	In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations.	Caffeine	40-48	transformation related protein 53, pseudogene	Mus musculus	154-157
15975959-10	2005	In summary, oral treatment of mice with caffeine or green tea during chronic UVB irradiation changed the mutation profile of the p53 gene in early mutant p53 positive epidermal patches, and topical applications of caffeine after discontinuation of chronic UVB irradiation specifically eliminated patches harboring homozygous p53 mutations.	Caffeine	40-48	transformation related protein 53, pseudogene	Mus musculus	154-157
16139976-11	2005	Caffeine also inhibited the UTP-induced [Ca(2+)](i) and mucin secretion.	Caffeine	0-8	LOC100508689	Homo sapiens	56-61
16138010-3	2005	We have found that inhibition of ATR and ATM kinases with caffeine or Chk1 with UCN-01, results in activation of a p38-dependent intra-S-phase checkpoint and activation of apoptosis in ES cells.	Caffeine	58-66	ataxia telangiectasia and Rad3 related	Mus musculus	33-36
16175570-4	2005	Treatment with caffeine and a low (1 microM) concentration of ryanodine, which activates the ryanodine receptor (RyR), exacerbates neuronal death, whereas dantrolene and 25 microM ryanodine, which antagonizes RyR, prevents damage.	Caffeine	15-23	ryanodine receptor 2	Homo sapiens	93-111
16175570-4	2005	Treatment with caffeine and a low (1 microM) concentration of ryanodine, which activates the ryanodine receptor (RyR), exacerbates neuronal death, whereas dantrolene and 25 microM ryanodine, which antagonizes RyR, prevents damage.	Caffeine	15-23	ryanodine receptor 2	Homo sapiens	113-116
16175570-4	2005	Treatment with caffeine and a low (1 microM) concentration of ryanodine, which activates the ryanodine receptor (RyR), exacerbates neuronal death, whereas dantrolene and 25 microM ryanodine, which antagonizes RyR, prevents damage.	Caffeine	15-23	ryanodine receptor 2	Homo sapiens	209-212
16231214-3	2005	The msb3 msb4 yeast double mutation causes growth inhibition in the presence of DMSO and/or caffeine, affects the organization of the actin cytoskeleton, produces a random budding pattern in diploid cells, and affects segregation of the nucleus.	Caffeine	92-100	Rab GTPase-activating protein MSB3	Saccharomyces cerevisiae S288C	4-8
16231214-3	2005	The msb3 msb4 yeast double mutation causes growth inhibition in the presence of DMSO and/or caffeine, affects the organization of the actin cytoskeleton, produces a random budding pattern in diploid cells, and affects segregation of the nucleus.	Caffeine	92-100	Rab GTPase-activating protein MSB4	Saccharomyces cerevisiae S288C	9-13
16231214-4	2005	To find cell components that interact genetically with the products of the MSB3 and MSB4 genes, we screened a genomic library for multicopy suppressor genes restoring normal growth of the double mutant in the presence of DMSO and caffeine.	Caffeine	230-238	Rab GTPase-activating protein MSB3	Saccharomyces cerevisiae S288C	75-79
16231214-4	2005	To find cell components that interact genetically with the products of the MSB3 and MSB4 genes, we screened a genomic library for multicopy suppressor genes restoring normal growth of the double mutant in the presence of DMSO and caffeine.	Caffeine	230-238	Rab GTPase-activating protein MSB4	Saccharomyces cerevisiae S288C	84-88
16138010-3	2005	We have found that inhibition of ATR and ATM kinases with caffeine or Chk1 with UCN-01, results in activation of a p38-dependent intra-S-phase checkpoint and activation of apoptosis in ES cells.	Caffeine	58-66	mitogen-activated protein kinase 14	Mus musculus	115-118
16138010-5	2005	Furthermore, the presence of caffeine results in activation of p38 kinase, accumulation of p21/Waf1 in a complex with Cdk2 and decrease of Cdk2 kinase activity.	Caffeine	29-37	mitogen-activated protein kinase 14	Mus musculus	63-66
16138010-5	2005	Furthermore, the presence of caffeine results in activation of p38 kinase, accumulation of p21/Waf1 in a complex with Cdk2 and decrease of Cdk2 kinase activity.	Caffeine	29-37	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	91-94
16138010-5	2005	Furthermore, the presence of caffeine results in activation of p38 kinase, accumulation of p21/Waf1 in a complex with Cdk2 and decrease of Cdk2 kinase activity.	Caffeine	29-37	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	95-99
16138010-5	2005	Furthermore, the presence of caffeine results in activation of p38 kinase, accumulation of p21/Waf1 in a complex with Cdk2 and decrease of Cdk2 kinase activity.	Caffeine	29-37	cyclin-dependent kinase 2	Mus musculus	118-122
16138010-5	2005	Furthermore, the presence of caffeine results in activation of p38 kinase, accumulation of p21/Waf1 in a complex with Cdk2 and decrease of Cdk2 kinase activity.	Caffeine	29-37	cyclin-dependent kinase 2	Mus musculus	139-143
16138010-6	2005	In contrast, caffeine-treated p38alpha-/- ES cells show less apoptosis, and fail to trigger an effective S-phase checkpoint and accumulation of p21/Waf1.	Caffeine	13-21	mitogen-activated protein kinase 14	Mus musculus	30-38
16138010-6	2005	In contrast, caffeine-treated p38alpha-/- ES cells show less apoptosis, and fail to trigger an effective S-phase checkpoint and accumulation of p21/Waf1.	Caffeine	13-21	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	148-152
16214893-3	2005	Using a subtractive cDNA library between untreated and caffeine-treated animal caps, i.e., control ectoderm and ectoderm induced toward a neural fate by a release of Ca2+, we have isolated the arginine N-methyltransferase, xPRMT1b, a Ca2+-induced target gene, which plays a pivotal role in this process.	Caffeine	55-63	protein arginine methyltransferase 1 L homeolog	Xenopus laevis	223-230
16138010-3	2005	We have found that inhibition of ATR and ATM kinases with caffeine or Chk1 with UCN-01, results in activation of a p38-dependent intra-S-phase checkpoint and activation of apoptosis in ES cells.	Caffeine	58-66	ataxia telangiectasia mutated	Mus musculus	41-44
16187758-1	2005	Caffeine sensitizes cells to ionizing radiation, and this effect is believed to be associated with the disruption of DNA damage-responsive cell cycle checkpoints, which is controlled by ATM.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	186-189
16189003-6	2005	The incubation of infected cells with caffeine, a known ATM inhibitor, did not block entry into S but reduced the rate of viral compared to cellular DNA synthesis.	Caffeine	38-46	ataxia telangiectasia mutated	Mus musculus	56-59
15994368-4	2005	We document that this arrest is sensitive to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpoint kinases ATM/ATM and Rad-3-related (ATR) and Chk1/Chk2, respectively.	Caffeine	72-80	ATM serine/threonine kinase	Homo sapiens	153-156
15994368-4	2005	We document that this arrest is sensitive to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpoint kinases ATM/ATM and Rad-3-related (ATR) and Chk1/Chk2, respectively.	Caffeine	72-80	ATM serine/threonine kinase	Homo sapiens	157-160
15994368-4	2005	We document that this arrest is sensitive to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpoint kinases ATM/ATM and Rad-3-related (ATR) and Chk1/Chk2, respectively.	Caffeine	72-80	ATR serine/threonine kinase	Homo sapiens	165-184
15994368-4	2005	We document that this arrest is sensitive to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpoint kinases ATM/ATM and Rad-3-related (ATR) and Chk1/Chk2, respectively.	Caffeine	72-80	checkpoint kinase 1	Homo sapiens	189-193
15994368-4	2005	We document that this arrest is sensitive to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpoint kinases ATM/ATM and Rad-3-related (ATR) and Chk1/Chk2, respectively.	Caffeine	72-80	checkpoint kinase 2	Homo sapiens	194-198
16129427-0	2005	Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice.	Caffeine	21-29	adenosine A2a receptor	Mus musculus	33-57
16129427-3	2005	These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.	Caffeine	101-109	adenosine A2a receptor	Mus musculus	44-68
16128905-10	2005	While caffeine clearance is considered as the gold standard, the salivary or plasma ratio of paraxanthine to caffeine in a sample taken approximately 6 hr after a defined dose of caffeine is a more convenient, less expensive but also fully validated CYP1A2 phenotyping metric.	Caffeine	109-117	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	250-256
16150277-2	2005	STUDY DESIGN: The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy.	Caffeine	76-84	bromodomain containing 2	Homo sapiens	18-21
16143772-0	2005	(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.	Caffeine	50-58	monoamine oxidase B	Homo sapiens	143-148
16128905-8	2005	Caffeine is most often used because of the predominating role of CYP1A2 in its overall metabolism and the excellent tolerability.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	65-71
16128905-10	2005	While caffeine clearance is considered as the gold standard, the salivary or plasma ratio of paraxanthine to caffeine in a sample taken approximately 6 hr after a defined dose of caffeine is a more convenient, less expensive but also fully validated CYP1A2 phenotyping metric.	Caffeine	109-117	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	250-256
15997229-1	2005	During the treatment of neonatal apnea, formula-fed infants, compared to breastfed infants, show nearly three-fold increase in clearance of caffeine, a substrate of cytochrome P450 1A (CYP1A) and in part CYP3A4.	Caffeine	140-148	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	204-210
15997229-11	2005	In conclusion, infant formula, but not human milk, enhances in vitro CYP1A expression via an AhR-mediated pathway, providing a potential mechanistic basis for the increased caffeine elimination in formula-fed infants.	Caffeine	173-181	aryl hydrocarbon receptor	Homo sapiens	93-96
16153396-0	2005	The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.	Caffeine	46-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	27-33
15980104-0	2005	Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.	Caffeine	87-95	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
15980104-1	2005	In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4).	Caffeine	5-13	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	92-98
15980104-1	2005	In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4).	Caffeine	5-13	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	289-295
15980104-1	2005	In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4).	Caffeine	5-13	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	297-305
16041547-7	2005	CYP1A2 activity was estimated by calculating the plasma paraxanthine to caffeine AUC ratio (caffeine metabolic ratio; CMR), CYP2C19 activity by the 2-h omeprazole hydroxylation index (HI), CYP2D6 activity by the urinary debrisoquine recovery ratio (DBRR) and CYP3A4 activity by midazolam clearance.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
16041547-7	2005	CYP1A2 activity was estimated by calculating the plasma paraxanthine to caffeine AUC ratio (caffeine metabolic ratio; CMR), CYP2C19 activity by the 2-h omeprazole hydroxylation index (HI), CYP2D6 activity by the urinary debrisoquine recovery ratio (DBRR) and CYP3A4 activity by midazolam clearance.	Caffeine	92-100	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
15879163-1	2005	Caffeine increases time to fatigue [limit of endurance (T(lim))] during submaximal isometric contractions without altering whole muscle activation or neuromuscular junction transmission.	Caffeine	0-8	PDZ and LIM domain 5	Homo sapiens	36-39
15879163-2	2005	We used 10 male volunteers in a randomized, double-blind, repeated-measures experiment to examine single motor unit firing rates during intermittent submaximal contractions and to determine whether administering caffeine increased T(lim) by maintaining higher firing rates.	Caffeine	212-220	PDZ and LIM domain 5	Homo sapiens	233-236
15879163-5	2005	Caffeine increased average T(lim) by 20.5 +/- 8.1% (P &lt; 0.05) compared with placebo conditions.	Caffeine	0-8	PDZ and LIM domain 5	Homo sapiens	29-32
16044420-0	2005	Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.	Caffeine	88-96	thymoma viral proto-oncogene 1	Mus musculus	70-73
16093919-4	2005	In addition, the production of renin and catecholamines was studied during infusion of adenosine, caffeine, or both.	Caffeine	98-106	renin	Homo sapiens	31-36
16156741-5	2005	Application of caffeine to mutant presenilin-1 knock-in neurons (PS1KI) and 3xTg-AD neurons evoked a peak rise of [Ca2+]i that was significantly greater than those observed in non-transgenic neurons, although all groups had similar decay rates of their Ca2+ transient.	Caffeine	15-23	presenilin 1	Mus musculus	34-46
16044420-4	2005	Interestingly, pretreatment with caffeine suppressed EGF-induced phosphorylation and activation of Akt and ribosomal p 70 S6 protein kinase (p 70 S 6 K), a target of Akt, without inhibiting phosphatidylinositol 3-kinase (PI 3 K) activation.	Caffeine	33-41	thymoma viral proto-oncogene 1	Mus musculus	99-102
16044420-4	2005	Interestingly, pretreatment with caffeine suppressed EGF-induced phosphorylation and activation of Akt and ribosomal p 70 S6 protein kinase (p 70 S 6 K), a target of Akt, without inhibiting phosphatidylinositol 3-kinase (PI 3 K) activation.	Caffeine	33-41	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	141-151
16044420-4	2005	Interestingly, pretreatment with caffeine suppressed EGF-induced phosphorylation and activation of Akt and ribosomal p 70 S6 protein kinase (p 70 S 6 K), a target of Akt, without inhibiting phosphatidylinositol 3-kinase (PI 3 K) activation.	Caffeine	33-41	thymoma viral proto-oncogene 1	Mus musculus	166-169
16044420-5	2005	The inhibition of Akt activation of caffeine was not a result of its adenosine receptor antagonism.	Caffeine	36-44	thymoma viral proto-oncogene 1	Mus musculus	18-21
16044420-6	2005	Because Akt plays a key role in signal transduction pathways leading to cell proliferation and apoptosis, our results provide novel insight into possible mechanisms of the chemotherapeutic effect of caffeine.	Caffeine	199-207	thymoma viral proto-oncogene 1	Mus musculus	8-11
16216047-8	2005	PCNA index was 0.4587 +/-0.1312 in control group, 0.1847+/-0.0535 in Group DDP, 0.4381 +/-0.0706 in Group caffeine, and 0.0314 +/-0.0231 in Group DDP+caffeine (P &lt;0.01).	Caffeine	106-114	proliferating cell nuclear antigen	Rattus norvegicus	0-4
16123242-0	2005	Caffeine promotes premature chromosome condensation formation and in vitro development in porcine reconstructed embryos via a high level of maturation promoting factor activity during nuclear transfer.	Caffeine	0-8	mesothelin	Homo sapiens	140-167
16123242-3	2005	In this study, we treated porcine NT embryos with caffeine, which has been reported to increase MPF activity, to keep their MPF level high during NT.	Caffeine	50-58	mesothelin	Homo sapiens	96-99
16123242-3	2005	In this study, we treated porcine NT embryos with caffeine, which has been reported to increase MPF activity, to keep their MPF level high during NT.	Caffeine	50-58	mesothelin	Homo sapiens	124-127
16123242-5	2005	In NT embryos treated with caffeine, the activity of p34(cdc2) kinase was significantly (P &lt; 0.05) higher than in those without caffeine at 3 h post-injection.	Caffeine	27-35	general transcription factor IIH subunit 3	Homo sapiens	53-56
16123242-5	2005	In NT embryos treated with caffeine, the activity of p34(cdc2) kinase was significantly (P &lt; 0.05) higher than in those without caffeine at 3 h post-injection.	Caffeine	27-35	cyclin dependent kinase 1	Homo sapiens	57-61
16216047-8	2005	PCNA index was 0.4587 +/-0.1312 in control group, 0.1847+/-0.0535 in Group DDP, 0.4381 +/-0.0706 in Group caffeine, and 0.0314 +/-0.0231 in Group DDP+caffeine (P &lt;0.01).	Caffeine	150-158	proliferating cell nuclear antigen	Rattus norvegicus	0-4
15817611-0	2005	Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice.	Caffeine	31-39	transformation related protein 53, pseudogene	Mus musculus	100-103
16038872-0	2005	Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites.	Caffeine	94-102	solute carrier family 22 member 6	Homo sapiens	61-88
15817611-7	2005	Oral administration of green tea (6 mg tea solids/ml) or caffeine (0.4 mg/ml) as the sole source of drinking fluid during irradiation with UVB, twice a week for 20 weeks, inhibited UVB-induced formation of mutant p53 positive patches by approximately 40%.	Caffeine	57-65	transformation related protein 53, pseudogene	Mus musculus	213-216
15817611-8	2005	Oral administration of green tea (6 mg tea solids/ml) as the sole source of drinking fluid or topical applications of caffeine (6.2 micromol) once a day 5 days a week starting immediately after discontinuation of UVB treatment enhanced the rate and extent of disappearance of the mutant p53-positive patches.	Caffeine	118-126	transformation related protein 53, pseudogene	Mus musculus	287-290
16061642-5	2005	Notably, HMGA2 enhances doxorubicin-elicited cell cycle delay in sub-G1 and G2-M and augments cell cycle dysregulation on cotreatment of doxorubicin and caffeine.	Caffeine	153-161	high mobility group AT-hook 2	Homo sapiens	9-14
16055184-1	2005	We have studied the effects of ryanodine and inhibition of the sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) with thapsigargin, on both [Ca(2+)](i) and the sarcoplasmic reticulum (SR) Ca(2+) level during caffeine-induced Ca(2+) release in single smooth muscle cells.	Caffeine	208-216	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	106-111
16055184-5	2005	Moreover, on removal of caffeine, the SR Ca(2+) levels partially recovered in 61% of the cells due to the activity of thapsigargin-sensitive SERCA pumps.	Caffeine	24-32	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	141-146
16055184-7	2005	It was necessary to previously inhibit SERCA pumps with thapsigargin for ryanodine to be able to induce caffeine-triggered permanent depletion of SR Ca(2+) stores.	Caffeine	104-112	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	39-44
16103443-7	2005	Caffeine was used to probe for cytochrome P450 1A2 (CYP1A2), N-acetyltransferase-2 (NAT-2), and xanthine oxidase.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-50
15863441-8	2005	Ca2+ sparks were recorded in both regions, and their activities were enhanced by a subthreshold concentration of caffeine or by endothelin-1, indicating functional RyR-gated Ca2+ stores.	Caffeine	113-121	ryanodine receptor 2	Rattus norvegicus	164-167
16103443-7	2005	Caffeine was used to probe for cytochrome P450 1A2 (CYP1A2), N-acetyltransferase-2 (NAT-2), and xanthine oxidase.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58
16103443-7	2005	Caffeine was used to probe for cytochrome P450 1A2 (CYP1A2), N-acetyltransferase-2 (NAT-2), and xanthine oxidase.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	84-89
16329491-6	2005	The result shows that NIR is feasible and superior in analyzing the content of caffeine in tea polyphenol.	Caffeine	79-87	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	22-25
16206866-3	2005	Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-37
15972723-8	2005	In support of this, RyR1-knockout myotubes expressing ASI(-) exhibited a decreased incidence of Ca2+ oscillations during caffeine exposure compared with that observed for myotubes expressing WT-RyR1.	Caffeine	121-129	ryanodine receptor 1, skeletal muscle	Mus musculus	20-24
16024610-8	2005	NO treatment also induced the phosphorylation of p53 at Ser15; pretreatment with phosphoinositide-3 kinase (PI3K) family inhibitors, wortmannin, LY294002, and caffeine, blocked such phosphorylation, but the p38 mitogen-activated protein kinase inhibitor, SB203580, did not.	Caffeine	159-167	tumor protein p53	Homo sapiens	49-52
18970138-1	2005	PLS-1, a variant of the partial least-squares algorithm was used for the solid-phase spectrofluorimetric determination of acetylsalicylic acid (ASA) and caffeine (CF) in pharmaceutical formulations.	Caffeine	153-161	plastin 1	Homo sapiens	0-5
15845578-9	2005	Following removal of IL-6, PRP and responsiveness to 10 mM caffeine were also reduced.	Caffeine	59-67	interleukin 6	Rattus norvegicus	21-25
15845578-11	2005	Furthermore, IL-6-elicited suppressions of PRP and responsiveness to caffeine and Ca2+o were abolished by L-NMMA and AMT.	Caffeine	69-77	interleukin 6	Rattus norvegicus	13-17
18970138-1	2005	PLS-1, a variant of the partial least-squares algorithm was used for the solid-phase spectrofluorimetric determination of acetylsalicylic acid (ASA) and caffeine (CF) in pharmaceutical formulations.	Caffeine	163-165	plastin 1	Homo sapiens	0-5
15677376-8	2005	However, DP4 sensitized RyR1 four- to six-fold to caffeine in the caffeine-induced Ca(2+) release.	Caffeine	50-58	transcription factor Dp family member 3	Homo sapiens	9-12
16007279-7	2005	A significant reduction of alpha absolute power over the entire scalp and of P300 latency at the Fz electrode were observed after caffeine ingestion.	Caffeine	130-138	E1A binding protein p300	Homo sapiens	77-81
15878845-2	2005	We have illustrated a functional interaction between TRPC1 channels and RyR1 for the regulation of store-operated calcium entry (SOCE) initiated after releasing calcium from a caffeine-sensitive intracellular calcium pool.	Caffeine	176-184	short transient receptor potential channel 1	Cricetulus griseus	53-58
15878845-2	2005	We have illustrated a functional interaction between TRPC1 channels and RyR1 for the regulation of store-operated calcium entry (SOCE) initiated after releasing calcium from a caffeine-sensitive intracellular calcium pool.	Caffeine	176-184	LOW QUALITY PROTEIN: ryanodine receptor 1	Cricetulus griseus	72-76
15878845-5	2005	Removing the foot structure from RyR1 results in normal caffeine-induced release of calcium from internal stores but abolishes the activation of SOCE, indicating that this structure is require for functional coupling to SOCs.	Caffeine	56-64	LOW QUALITY PROTEIN: ryanodine receptor 1	Cricetulus griseus	33-37
16076989-5	2005	At baseline, satiety was positively, and in women, leptin was inversely, related to subjects" habitual caffeine consumption (p &lt; 0.01).	Caffeine	103-111	leptin	Homo sapiens	51-57
16076989-9	2005	DISCUSSION: High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women.	Caffeine	17-25	leptin	Homo sapiens	125-131
15659716-0	2005	CaM kinase II and phospholamban contribute to caffeine-induced relaxation of murine gastric fundus smooth muscle.	Caffeine	46-54	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	0-13
15659716-5	2005	Caffeine (1 mM) hyperpolarized and relaxed murine gastric fundus smooth muscle and activated CaMKII.	Caffeine	0-8	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	93-99
15659716-8	2005	Caffeine-induced CaMKII activation increased PLB Thr17, but not PLB Ser16 phosphorylation.	Caffeine	0-8	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	17-23
15659716-10	2005	The CaMKII inhibitor KN-93 inhibited caffeine-induced relaxation and PLB Thr17 phosphorylation.	Caffeine	37-45	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	4-10
15967394-3	2005	RESULTS: There is wide inter-individual variation in caffeine metabolism, primarily due to variations in CYP1A2 enzyme activity.	Caffeine	53-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	105-111
15993240-2	2005	We induced local release of Ca2+ by regional exposure of mouse atrial and ventricular myocytes to 10mM caffeine for 500 ms using a rapid solution switcher.	Caffeine	103-111	carbonic anhydrase 2	Mus musculus	28-31
15998294-1	2005	Pregnant rats were treated throughout the gestational period with either caffeine or theophylline, and its effect on the metabotropic glutamate receptor (mGluRs) signal transduction pathway was studied in both maternal and fetal brain.	Caffeine	73-81	glutamate metabotropic receptor 1	Rattus norvegicus	154-160
15998294-6	2005	In fetal brain, a loss in total mGluRs was observed in fetuses from mothers treated with caffeine or theophylline, without variation in receptor affinity.	Caffeine	89-97	glutamate metabotropic receptor 1	Rattus norvegicus	32-38
15659716-11	2005	These results show that caffeine-induced CaMKII activation and PLB phosphorylation play a role in the relaxation of gastric fundus smooth muscles.	Caffeine	24-32	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	41-47
15677376-8	2005	However, DP4 sensitized RyR1 four- to six-fold to caffeine in the caffeine-induced Ca(2+) release.	Caffeine	66-74	transcription factor Dp family member 3	Homo sapiens	9-12
15677376-8	2005	However, DP4 sensitized RyR1 four- to six-fold to caffeine in the caffeine-induced Ca(2+) release.	Caffeine	66-74	ryanodine receptor 1	Homo sapiens	24-28
15831461-4	2005	These phosphorylations were inhibited by ATR siRNA and caffeine, but they occurred independently of ATM.	Caffeine	55-63	ATR serine/threonine kinase	Homo sapiens	41-44
15920057-0	2005	Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women.	Caffeine	46-54	insulin	Homo sapiens	77-86
15920057-3	2005	In this study, we examined consumption of caffeinated and decaffeinated coffee and total caffeine in relation to concentrations of plasma C-peptide.	Caffeine	89-97	insulin	Homo sapiens	138-147
15920057-6	2005	RESULTS: Intakes of caffeinated and decaffeinated coffee and caffeine in 1990 were each inversely associated with C-peptide concentration in age-adjusted, BMI-adjusted, and multivariable-adjusted analyses.	Caffeine	61-69	insulin	Homo sapiens	114-123
15920057-8	2005	Women in the highest quintile compared with the lowest quintile of caffeine intake had 10% lower C-peptide levels (P = 0.02).	Caffeine	67-75	insulin	Homo sapiens	97-106
15845383-5	2005	Although resting [Ca(2+)](c) was comparable in all cells, RyR2 mutants were characterised by a profound loss of Ca(2+)-dependent inhibition following caffeine stimulation when compared with WT channels.	Caffeine	150-158	ryanodine receptor 2	Homo sapiens	58-62
15840517-5	2005	In this study, we show that an inhibitor of ATR and ATM kinases, caffeine, can suppress replication of infectious HIV-1 strains, and provide evidence that caffeine exerts its inhibitory effect at the integration step of the HIV-1 life-cycle.	Caffeine	65-73	ATR serine/threonine kinase	Homo sapiens	44-47
15840517-5	2005	In this study, we show that an inhibitor of ATR and ATM kinases, caffeine, can suppress replication of infectious HIV-1 strains, and provide evidence that caffeine exerts its inhibitory effect at the integration step of the HIV-1 life-cycle.	Caffeine	65-73	ATM serine/threonine kinase	Homo sapiens	52-55
15840517-5	2005	In this study, we show that an inhibitor of ATR and ATM kinases, caffeine, can suppress replication of infectious HIV-1 strains, and provide evidence that caffeine exerts its inhibitory effect at the integration step of the HIV-1 life-cycle.	Caffeine	155-163	ATR serine/threonine kinase	Homo sapiens	44-47
15741596-8	2005	In the case of caffeine, response was decreased by expression of GRK2 only when cells were activated by 1 mM caffeine.	Caffeine	15-23	G protein-coupled receptor kinase 2	Homo sapiens	65-69
15741596-8	2005	In the case of caffeine, response was decreased by expression of GRK2 only when cells were activated by 1 mM caffeine.	Caffeine	109-117	G protein-coupled receptor kinase 2	Homo sapiens	65-69
16059590-0	2005	[Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].	Caffeine	28-36	ETS transcription factor ELK3	Homo sapiens	62-85
16059590-3	2005	OBJECTIVE: To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database.	Caffeine	53-61	ETS transcription factor ELK3	Homo sapiens	91-94
15890976-3	2005	In vitro functional characterization of mutant RyR2 channels showed altered behavior on adrenergic stimulation and caffeine administration with enhanced calcium release from the sarcoplasmic reticulum.	Caffeine	115-123	ryanodine receptor 2, cardiac	Mus musculus	47-51
15890976-8	2005	These data provide the first experimental demonstration that the R4496C RyR2 mutation predisposes the murine heart to VT and VF in response caffeine and/or adrenergic stimulation.	Caffeine	140-148	ryanodine receptor 2, cardiac	Mus musculus	72-76
15836904-4	2005	Motor impairments occurred in 15-, 18- and 21-day-old rats treated with caffeine at P7-P11, whereas, pups exposed to caffeine from P13 to P17 exhibited worse performance only in the bar holding test at the age of 18 days.	Caffeine	72-80	S100 calcium binding protein A10	Rattus norvegicus	87-90
15735681-4	2005	The results indicate that ATM kinase is likely to be indispensable for the p53-dependent S-phase checkpoint since the suppression was abrogated by inhibitors such as caffeine and wortmannin.	Caffeine	166-174	ataxia telangiectasia mutated	Mus musculus	26-29
15735681-4	2005	The results indicate that ATM kinase is likely to be indispensable for the p53-dependent S-phase checkpoint since the suppression was abrogated by inhibitors such as caffeine and wortmannin.	Caffeine	166-174	transformation related protein 53, pseudogene	Mus musculus	75-78
15927451-0	2005	Inhibition of human TREK-1 channels by caffeine and theophylline.	Caffeine	39-47	potassium two pore domain channel subfamily K member 2	Homo sapiens	20-26
15927451-4	2005	In view of their physiological significance, inhibition of TREK-1 channels may be implicated in caffeine- and theophylline-induced seizures.	Caffeine	96-104	potassium two pore domain channel subfamily K member 2	Homo sapiens	59-65
15927451-5	2005	We thus investigated, using whole-cell patch-clamp technique, modulation of hTREK-1 channels expressed in Chinese hamster ovary (CHO) cells by caffeine and theophylline.	Caffeine	143-151	potassium two pore domain channel subfamily K member 2	Homo sapiens	76-83
15927451-6	2005	Caffeine and theophylline produced reversible inhibition of TREK-1 channels in a concentration-dependent manner.	Caffeine	0-8	potassium two pore domain channel subfamily K member 2	Homo sapiens	60-66
15927451-8	2005	Caffeine and theophylline depolarized the membrane potential of CHO(TREK-1) cells in a reversible and concentration-dependent manner.	Caffeine	0-8	potassium two pore domain channel subfamily K member 2	Homo sapiens	68-74
15927451-9	2005	Inhibition by caffeine (5mM) and theophylline (2mM) was attenuated in TREK-1 channels with mutation of the PKA consensus sequence at serine 348, suggesting the involvement of cAMP/PKA pathway in the inhibitory process.	Caffeine	14-22	potassium two pore domain channel subfamily K member 2	Homo sapiens	70-76
15927451-10	2005	Inhibition of TREK-1 channels and consequent membrane depolarization may contribute to the convulsive seizures induced by toxic levels of caffeine and theophylline.	Caffeine	138-146	potassium two pore domain channel subfamily K member 2	Homo sapiens	14-20
15981576-0	2005	[Caffeine sensitivity of the yeast Saccharomyces cerevisiae MCD4 mutant is related to alteration of calcium homeostasis and degradation of misfolded proteins].	Caffeine	1-9	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	60-64
15774265-1	2005	The adenosine A2a receptor (A2aAR) is thought to be implicated in the pathogenesis of panic disorder because caffeine, a potent antagonist for A2aAR, can precipitate panic attacks, and because disruption of the A2aAR gene increased anxiety-behaviors in mice.	Caffeine	109-117	adenosine A2a receptor	Mus musculus	4-26
15981576-3	2005	The ssu21 mutation in the MCD4 gene studied here causes sensitivity to caffeine.	Caffeine	71-79	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	4-9
15981576-3	2005	The ssu21 mutation in the MCD4 gene studied here causes sensitivity to caffeine.	Caffeine	71-79	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	26-30
15981576-4	2005	The screen for multicopy suppressors of caffeine sensitivity caused by the ssu21 mutation revealed genes involved in aminoglycerophospholipid metabolism, unfolded protein response, and protein degradation.	Caffeine	40-48	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	75-80
15981576-6	2005	Obtained results indicate that caffeine sensitivity caused by the ssu21 mutation could be due to cytoplasmic accumulation of misfolded proteins destined for degradation.	Caffeine	31-39	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	66-71
15696333-8	2005	RESULTS: DMPX and CPT, but not MSX-3, produced significant caffeine-like discriminative effects.	Caffeine	59-67	choline phosphotransferase 1	Homo sapiens	18-21
15696333-9	2005	MSX-3, but not CPT, markedly reduced the discriminative effects of caffeine and the caffeine-like discriminative effects of CPT.	Caffeine	67-75	msh homeobox 3	Rattus norvegicus	0-5
15696333-9	2005	MSX-3, but not CPT, markedly reduced the discriminative effects of caffeine and the caffeine-like discriminative effects of CPT.	Caffeine	84-92	msh homeobox 3	Rattus norvegicus	0-5
15696333-9	2005	MSX-3, but not CPT, markedly reduced the discriminative effects of caffeine and the caffeine-like discriminative effects of CPT.	Caffeine	84-92	choline phosphotransferase 1	Homo sapiens	124-127
15701627-7	2005	Caffeine, an inhibitor of the upstream checkpoint kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related), has no effect on the early inhibition of DNA synthesis, but cells are no longer able to maintain the block after 8 h. Instead, the addition of caffeine leads to arrest of cells in G(2)/M rather than S-phase after 24 h. Analysis of signaling pathways in cell extracts reveals an activation of Chk1 after treatment with MMS and 4-AN, which can be suppressed by caffeine.	Caffeine	0-8	ataxia telangiectasia mutated	Mus musculus	58-61
15701627-7	2005	Caffeine, an inhibitor of the upstream checkpoint kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related), has no effect on the early inhibition of DNA synthesis, but cells are no longer able to maintain the block after 8 h. Instead, the addition of caffeine leads to arrest of cells in G(2)/M rather than S-phase after 24 h. Analysis of signaling pathways in cell extracts reveals an activation of Chk1 after treatment with MMS and 4-AN, which can be suppressed by caffeine.	Caffeine	0-8	ataxia telangiectasia and Rad3 related	Mus musculus	98-101
15701627-7	2005	Caffeine, an inhibitor of the upstream checkpoint kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related), has no effect on the early inhibition of DNA synthesis, but cells are no longer able to maintain the block after 8 h. Instead, the addition of caffeine leads to arrest of cells in G(2)/M rather than S-phase after 24 h. Analysis of signaling pathways in cell extracts reveals an activation of Chk1 after treatment with MMS and 4-AN, which can be suppressed by caffeine.	Caffeine	0-8	checkpoint kinase 1	Mus musculus	418-422
15843617-6	2005	4-AP and 3,4-diaminopyridine (3,4-DiAP), which have relatively high affinities for K(v) channels, reduced the frequency of restraint- and caffeine-induced attacks.	Caffeine	138-146	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	34-38
15774265-1	2005	The adenosine A2a receptor (A2aAR) is thought to be implicated in the pathogenesis of panic disorder because caffeine, a potent antagonist for A2aAR, can precipitate panic attacks, and because disruption of the A2aAR gene increased anxiety-behaviors in mice.	Caffeine	109-117	adenosine A2a receptor	Mus musculus	28-33
15774265-1	2005	The adenosine A2a receptor (A2aAR) is thought to be implicated in the pathogenesis of panic disorder because caffeine, a potent antagonist for A2aAR, can precipitate panic attacks, and because disruption of the A2aAR gene increased anxiety-behaviors in mice.	Caffeine	109-117	adenosine A2a receptor	Mus musculus	143-148
15774265-1	2005	The adenosine A2a receptor (A2aAR) is thought to be implicated in the pathogenesis of panic disorder because caffeine, a potent antagonist for A2aAR, can precipitate panic attacks, and because disruption of the A2aAR gene increased anxiety-behaviors in mice.	Caffeine	109-117	adenosine A2a receptor	Mus musculus	143-148
15857573-5	2005	A regional release of Ca2+ induced by an exposure of one end of the myocyte to caffeine with a rapid solution switcher resulted in a uniform propagation of Ca2+ down the length of the cell in atrial myocytes, but we found no propagation in ventricular myocytes.	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	22-25
15824259-1	2005	BACKGROUND: Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare disorder characterized by attacks of involuntary movements brought on by stress, alcohol, or caffeine, but not by movement.	Caffeine	159-167	PNKD metallo-beta-lactamase domain containing	Homo sapiens	50-54
15634940-1	2005	In airway smooth muscle cells, interleukin (IL)-4 inhibited both carbachol- and caffeine-induced calcium mobilization from the sarcoplasmic reticulum (SR).	Caffeine	80-88	interleukin 4	Bos taurus	31-49
15634940-2	2005	Because of the known signaling pathways for IL-4 and importance of calcium uptake in maintaining SR calcium stores shared by agonists and caffeine, it was hypothesized that this rapid inhibitory effect might depend on phosphatidylinositol 3-kinase (PI3K) and on inhibition of calcium uptake by the SR. Enzyme-dispersed bovine trachealis cells were loaded with Fura-2/acetoxymethyl ester, and changes in cytosolic calcium were imaged in single cells.	Caffeine	138-146	interleukin 4	Bos taurus	44-48
15634940-2	2005	Because of the known signaling pathways for IL-4 and importance of calcium uptake in maintaining SR calcium stores shared by agonists and caffeine, it was hypothesized that this rapid inhibitory effect might depend on phosphatidylinositol 3-kinase (PI3K) and on inhibition of calcium uptake by the SR. Enzyme-dispersed bovine trachealis cells were loaded with Fura-2/acetoxymethyl ester, and changes in cytosolic calcium were imaged in single cells.	Caffeine	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	218-247
15857573-5	2005	A regional release of Ca2+ induced by an exposure of one end of the myocyte to caffeine with a rapid solution switcher resulted in a uniform propagation of Ca2+ down the length of the cell in atrial myocytes, but we found no propagation in ventricular myocytes.	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	156-159
15857573-8	2005	Ventricular myocytes showed the presence of local control, as indicated by an absence of the propagation of a local caffeine-induced Ca2+ transient.	Caffeine	116-124	carbonic anhydrase 2	Rattus norvegicus	133-136
15755825-5	2005	The consumption of caffeine was analyzed by quintiles with Cox proportional-hazard models.	Caffeine	19-27	cytochrome c oxidase subunit 8A	Homo sapiens	59-62
15670867-5	2005	When the MGLC were stimulated with activators of RyR, 2 microM ryanodine and 10 mM caffeine, the ATP-elicited response was decreased.	Caffeine	83-91	ryanodine receptor 1, skeletal muscle	Mus musculus	49-52
15499078-9	2005	Nevertheless, caffeine caused a concentration-dependent relaxation in gallbladder strips either under resting tone conditions or precontracted with 1 muM CCK.	Caffeine	14-22	cholecystokinin	Homo sapiens	154-157
15752377-6	2005	In each patient the CYP1A2 activity was determined using caffeine as a metabolic probe.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
15752377-8	2005	RESULTS: Riluzole clearance and the serum paraxanthine : caffeine (P/C) ratio showed a positive correlation (r = 0.693; P = 0.0002).	Caffeine	57-65	pyruvate carboxylase	Homo sapiens	67-70
15752380-8	2005	Caffeine clearance was 0.083 l min(-1) (CV 38%) and decreased to 0.038 l min(-1) in presence of oral contraceptive therapy, its volume of distribution was 38.6 l (CV 20%) and its absorption rate constant was 0.064 l min(-1) (CV 50%).	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	31-37
15752380-8	2005	Caffeine clearance was 0.083 l min(-1) (CV 38%) and decreased to 0.038 l min(-1) in presence of oral contraceptive therapy, its volume of distribution was 38.6 l (CV 20%) and its absorption rate constant was 0.064 l min(-1) (CV 50%).	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	73-79
15752380-8	2005	Caffeine clearance was 0.083 l min(-1) (CV 38%) and decreased to 0.038 l min(-1) in presence of oral contraceptive therapy, its volume of distribution was 38.6 l (CV 20%) and its absorption rate constant was 0.064 l min(-1) (CV 50%).	Caffeine	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	73-79
15548569-5	2005	Although some of the increased sensitivity of RyR3 to caffeine could be attributed to the higher [Ca(2+)](r) in RyR3-expressing cells, studies of [(3)H]ryanodine binding demonstrated intrinsic differences in caffeine sensitivity between RyR1 and RyR3.	Caffeine	54-62	ryanodine receptor 3	Homo sapiens	46-50
15781964-1	2005	In a previous study, we showed that the psychoactive drug caffeine alters the expression of the dopamine 2 receptor (D2R) gene in vitro and in vivo.	Caffeine	58-66	dopamine receptor D2	Mus musculus	96-115
15735189-1	2005	OBJECTIVE: We investigated the effect of caffeine ingestion on insulin sensitivity in sedentary lean men (n = 8) and obese men with (n = 7) and without (n = 8) type 2 diabetes.	Caffeine	41-49	insulin	Homo sapiens	63-70
15735189-5	2005	RESULTS: At baseline, caffeine ingestion was associated with a significant reduction (P &lt; 0.05) in insulin sensitivity by a similar magnitude in the lean (33%), obese (33%), and type 2 diabetic (37%) groups in comparison with placebo.	Caffeine	22-30	insulin	Homo sapiens	102-109
15735189-6	2005	After exercise training, caffeine ingestion was still associated with a reduction (P &lt; 0.05) in insulin sensitivity by a similar magnitude in the lean (23%), obese (26%), and type 2 diabetic (36%) groups in comparison with placebo.	Caffeine	25-33	insulin	Homo sapiens	99-106
15735189-8	2005	CONCLUSIONS: Caffeine consumption is associated with a substantial reduction in insulin-mediated glucose uptake independent of obesity, type 2 diabetes, and chronic exercise.	Caffeine	13-21	insulin	Homo sapiens	80-87
15578203-9	2005	These findings suggest that caffeine ingestion is associated with alterations in lymphocyte subset trafficking and expression of CD69 in vivo following prolonged, intensive exercise.	Caffeine	28-36	CD69 molecule	Homo sapiens	129-133
15709017-7	2005	Finally, treatment of target cells with the ATM and ATR inhibitors caffeine and wortmannin was without effect in these infectivity assays.	Caffeine	67-75	ATR serine/threonine kinase	Homo sapiens	52-55
15665079-4	2005	Wortmannin and caffeine appear to act through the phosphoinositide 3-kinase-related protein kinases Tel1 and Mec1, known regulators of telomere length.	Caffeine	15-23	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	100-104
15665079-4	2005	Wortmannin and caffeine appear to act through the phosphoinositide 3-kinase-related protein kinases Tel1 and Mec1, known regulators of telomere length.	Caffeine	15-23	protein kinase MEC1	Saccharomyces cerevisiae S288C	109-113
15676021-3	2005	We first observed that Ara-C-induced differentiation of these cells is completely inhibited by the radiosensitizing agent caffeine, an inhibitor of ATM and ATR protein kinases.	Caffeine	122-130	ATP binding cassette subfamily C member 6	Homo sapiens	23-26
15676021-3	2005	We first observed that Ara-C-induced differentiation of these cells is completely inhibited by the radiosensitizing agent caffeine, an inhibitor of ATM and ATR protein kinases.	Caffeine	122-130	ATM serine/threonine kinase	Homo sapiens	148-151
15676021-4	2005	We next found that Ara-C activates Chk1 and Chk2 in the cells, and that the activation of Chk1, but not of Chk2, was almost completely inhibited by caffeine.	Caffeine	148-156	ATP binding cassette subfamily C member 6	Homo sapiens	19-22
15650224-4	2005	HHV-6B infection induced Ser20 and Ser15 phosphorylation on p53, and the latter was inhibited by caffeine, an ataxia telangiectasia mutated kinase inhibitor.	Caffeine	97-105	tumor protein p53	Homo sapiens	60-63
15620706-0	2005	Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.	Caffeine	52-60	replication protein A1	Homo sapiens	8-12
15620706-0	2005	Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.	Caffeine	52-60	checkpoint kinase 2	Homo sapiens	21-25
15620706-3	2005	However, the induction of Chk2 (Thr68) phosphorylation and p21 expression by RPA1 siRNA transfection can be completely blocked by the ATM inhibitor caffeine.	Caffeine	148-156	checkpoint kinase 2	Homo sapiens	26-30
15620706-3	2005	However, the induction of Chk2 (Thr68) phosphorylation and p21 expression by RPA1 siRNA transfection can be completely blocked by the ATM inhibitor caffeine.	Caffeine	148-156	H3 histone pseudogene 16	Homo sapiens	59-62
15620706-3	2005	However, the induction of Chk2 (Thr68) phosphorylation and p21 expression by RPA1 siRNA transfection can be completely blocked by the ATM inhibitor caffeine.	Caffeine	148-156	replication protein A1	Homo sapiens	77-81
15317663-5	2005	Using an amphotericin-perforated patch-clamp technique in fluo-3-loaded myocytes, we measured the caffeine-induced inward NCX current (I(NCX)) and the Ca(2+) transient.	Caffeine	98-106	T cell leukemia homeobox 2	Homo sapiens	122-125
15317663-5	2005	Using an amphotericin-perforated patch-clamp technique in fluo-3-loaded myocytes, we measured the caffeine-induced inward NCX current (I(NCX)) and the Ca(2+) transient.	Caffeine	98-106	T cell leukemia homeobox 2	Homo sapiens	137-140
16280596-3	2005	Genes that were significantly upregulated in caffeine-treated brains included those involved in synaptic signaling (GABA:Na symporter, dopamine D2R-like receptor, and synapsin), cytoskeletal modifications (kinesin and microtubule motors), protein translation (ribosomal protein RpL4, elongation factors), and calcium-dependent processes (calcium transporter, calmodulin- dependent cyclic nucleotide phosphodiesterase).	Caffeine	45-53	synapsin	Apis mellifera	144-175
16280596-3	2005	Genes that were significantly upregulated in caffeine-treated brains included those involved in synaptic signaling (GABA:Na symporter, dopamine D2R-like receptor, and synapsin), cytoskeletal modifications (kinesin and microtubule motors), protein translation (ribosomal protein RpL4, elongation factors), and calcium-dependent processes (calcium transporter, calmodulin- dependent cyclic nucleotide phosphodiesterase).	Caffeine	45-53	60S ribosomal protein L4	Apis mellifera	278-282
15676021-4	2005	We next found that Ara-C activates Chk1 and Chk2 in the cells, and that the activation of Chk1, but not of Chk2, was almost completely inhibited by caffeine.	Caffeine	148-156	checkpoint kinase 1	Homo sapiens	90-94
15676021-4	2005	We next found that Ara-C activates Chk1 and Chk2 in the cells, and that the activation of Chk1, but not of Chk2, was almost completely inhibited by caffeine.	Caffeine	148-156	checkpoint kinase 2	Homo sapiens	107-111
15389585-6	2005	This is further supported by the observation that initial H2AX phosphorylation is delayed when both kinases are inhibited by wortmannin, as well as when ATM is inhibited by caffeine in DNA-PK deficient cells.	Caffeine	173-181	ATM serine/threonine kinase	Homo sapiens	153-156
15389585-6	2005	This is further supported by the observation that initial H2AX phosphorylation is delayed when both kinases are inhibited by wortmannin, as well as when ATM is inhibited by caffeine in DNA-PK deficient cells.	Caffeine	173-181	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	185-191
15389585-8	2005	Treatment with wortmannin, caffeine, or UCN-01 produces a strong DNA-PK dependent late global hyperphosphorylation of H2AX, uncoupled from DNA DSB rejoining and compatible with an inhibition of late steps in DNA DSB processing.	Caffeine	27-35	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	65-71
15389585-8	2005	Treatment with wortmannin, caffeine, or UCN-01 produces a strong DNA-PK dependent late global hyperphosphorylation of H2AX, uncoupled from DNA DSB rejoining and compatible with an inhibition of late steps in DNA DSB processing.	Caffeine	27-35	H2A.X variant histone	Homo sapiens	118-122
15822860-3	2005	Treatment with caffeine similarly activated CYP1A2 and related monooxygenases as well as UGT, while treatment with catechins induced UGT activity but not 7-ECOD or CN1D activity.	Caffeine	15-23	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	44-50
16238096-4	2005	The role of ATM/ATR in the G2 checkpoint pathway repairing chromosomal aberrations was unveiled by caffeine inhibition of both kinases in G2.	Caffeine	99-107	ATM serine/threonine kinase	Homo sapiens	12-15
16238096-4	2005	The role of ATM/ATR in the G2 checkpoint pathway repairing chromosomal aberrations was unveiled by caffeine inhibition of both kinases in G2.	Caffeine	99-107	ATR serine/threonine kinase	Homo sapiens	16-19
15633120-0	2005	Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States.	Caffeine	11-19	glutamic--pyruvic transaminase	Homo sapiens	66-90
15633120-1	2005	BACKGROUND &amp; AIMS: Based on experimental and epidemiologic studies, we investigated whether coffee and caffeine consumption reduced the risk of elevated alanine aminotransferase (ALT) activity in persons at high risk for liver injury in a national, population-based study.	Caffeine	107-115	glutamic--pyruvic transaminase	Homo sapiens	157-181
15781964-1	2005	In a previous study, we showed that the psychoactive drug caffeine alters the expression of the dopamine 2 receptor (D2R) gene in vitro and in vivo.	Caffeine	58-66	dopamine receptor D2	Mus musculus	117-120
15505097-9	2004	Caffeine-induced Ca2+ transients indicated significantly increased SR Ca2+ content in Ad-SERCA1a-infected cells, by 72% at MOI 10 and by 87% at MOI 50.	Caffeine	0-8	sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	89-96
15598702-8	2005	It is concluded that even after short-term exposure, black tea enhances the metabolism of 6-aminochrysene and that this is probably related to the up-regulation of hepatic CYP1A2 by the caffeine present in black tea.	Caffeine	186-194	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	172-178
15469935-8	2004	Disruption of three additional putative RyR1 calcium binding motifs located between amino acid positions 4254 and 4265 (EF3), 4407 and 4418 (EF4), or 4490 and 4502 (EF5) either singly or in combination (EF3-5) did not affect functional responses in 1B5 myotubes except that the EC(50) for caffeine activation for the EF3 construct was significantly increased compared with wtRyR1.	Caffeine	289-297	ryanodine receptor 1	Oryctolagus cuniculus	40-44
18370706-1	2005	A number of reports have observed that acute caffeine ingestion decreases glucose tolerance and insulin sensitivity, and have raised the question whether its increased consumption throughout the world in the form of coffee and cola beverages might be of public health concern in the development of type 2 diabetes.	Caffeine	45-53	insulin	Homo sapiens	96-103
15708489-5	2005	Moreover, adenylyl cyclase inhibition elicited by N(6)-cyclohexyladenosine, specific adenosine A(1) receptor agonist, was also significantly decreased in caffeine- (40.5%) and theophylline- (55.0%) treated mothers, suggesting a desensitization of adenosine A(1) receptor/adenylyl cyclase pathway in maternal brain.	Caffeine	154-162	adenosine A1 receptor	Rattus norvegicus	85-108
15708489-5	2005	Moreover, adenylyl cyclase inhibition elicited by N(6)-cyclohexyladenosine, specific adenosine A(1) receptor agonist, was also significantly decreased in caffeine- (40.5%) and theophylline- (55.0%) treated mothers, suggesting a desensitization of adenosine A(1) receptor/adenylyl cyclase pathway in maternal brain.	Caffeine	154-162	adenosine A1 receptor	Rattus norvegicus	247-270
15592331-7	2004	A caffeine test was used as a marker for CYP1A2 activity.	Caffeine	2-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
15569276-0	2004	Adenosine A1 receptor blockade mimics caffeine"s attenuation of ethanol-induced motor incoordination.	Caffeine	38-46	adenosine A1 receptor	Rattus norvegicus	0-21
15569276-8	2004	These data demonstrate that adenosine A(1) receptor blockade mimics the inhibitory action of caffeine on ethanol-induced motor incorordination, and may contribute to the ability of caffeine to offset the acute intoxicating actions of ethanol.	Caffeine	93-101	adenosine A1 receptor	Rattus norvegicus	28-51
15569276-8	2004	These data demonstrate that adenosine A(1) receptor blockade mimics the inhibitory action of caffeine on ethanol-induced motor incorordination, and may contribute to the ability of caffeine to offset the acute intoxicating actions of ethanol.	Caffeine	181-189	adenosine A1 receptor	Rattus norvegicus	28-51
15536124-5	2004	This intra-S-phase checkpoint can be overcome by caffeine, an inhibitor of the ATM/ATR checkpoint kinases, or by neutralizing antibodies to ATR.	Caffeine	49-57	ATM serine/threonine kinase L homeolog	Xenopus laevis	79-82
15567976-7	2004	In fact, caffeine appears to exacerbate the effect of ethanol to deplete liver glycogen, decrease epididymal fat pad weight and lower serum leptin.	Caffeine	9-17	leptin	Rattus norvegicus	140-146
15530891-0	2004	Caffeine-dependent stimulus-triggered oscillations in the CA3 region of hippocampal slices from rats chronically exposed to lead.	Caffeine	0-8	carbonic anhydrase 3	Rattus norvegicus	58-61
15530891-8	2004	In the presence of 0.1 mM caffeine, in CA3 of 44 of 45 (97.8%) slices from chronic lead-exposed rats, single electrical stimuli triggered a burst of high-frequency oscillations (approximately 230 Hz), whereas in CA3 of caffeine-treated slices from control rats, such oscillations could be elicited in only 2 of 24 (8.3%) slices.	Caffeine	26-34	carbonic anhydrase 3	Rattus norvegicus	39-42
15530891-8	2004	In the presence of 0.1 mM caffeine, in CA3 of 44 of 45 (97.8%) slices from chronic lead-exposed rats, single electrical stimuli triggered a burst of high-frequency oscillations (approximately 230 Hz), whereas in CA3 of caffeine-treated slices from control rats, such oscillations could be elicited in only 2 of 24 (8.3%) slices.	Caffeine	26-34	carbonic anhydrase 3	Rattus norvegicus	212-215
15530891-13	2004	Caffeine-dependent oscillations are insensitive to an antagonist of gamma-aminobutyric acid (GABAA) receptors (10 microM bicuculline), L-type Ca2+ channels (10 muM nicardipine), L-type and N-type voltage-dependent calcium channels (100 microM Cd2)), and T-type Ca2+ channels (100 microM Ni2+).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	142-145
15530891-13	2004	Caffeine-dependent oscillations are insensitive to an antagonist of gamma-aminobutyric acid (GABAA) receptors (10 microM bicuculline), L-type Ca2+ channels (10 muM nicardipine), L-type and N-type voltage-dependent calcium channels (100 microM Cd2)), and T-type Ca2+ channels (100 microM Ni2+).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	261-264
15530891-15	2004	We propose that caffeine-dependent stimulus-induced oscillations in CA3 area of hippocampus from chronic lead-exposed rats are mainly mediated by the entry of extracellular Ca2+ through NMDA and non-NMDA receptors, without participation of GABAA receptors.	Caffeine	16-24	carbonic anhydrase 3	Rattus norvegicus	68-71
15530891-15	2004	We propose that caffeine-dependent stimulus-induced oscillations in CA3 area of hippocampus from chronic lead-exposed rats are mainly mediated by the entry of extracellular Ca2+ through NMDA and non-NMDA receptors, without participation of GABAA receptors.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	173-176
15572670-7	2004	UVB-induced C/EBPalpha was accompanied by an increase in p53 protein and caffeine, an inhibitor of ataxia-telangiectasia-mutated kinase, and ataxia-telangiectasia-mutated and Rad3-related kinase inhibited UVB-induced increases in both C/EBPalpha and p53.	Caffeine	73-81	CCAAT enhancer binding protein alpha	Homo sapiens	12-22
15572670-7	2004	UVB-induced C/EBPalpha was accompanied by an increase in p53 protein and caffeine, an inhibitor of ataxia-telangiectasia-mutated kinase, and ataxia-telangiectasia-mutated and Rad3-related kinase inhibited UVB-induced increases in both C/EBPalpha and p53.	Caffeine	73-81	ATM serine/threonine kinase	Homo sapiens	99-194
15536124-5	2004	This intra-S-phase checkpoint can be overcome by caffeine, an inhibitor of the ATM/ATR checkpoint kinases, or by neutralizing antibodies to ATR.	Caffeine	49-57	ANTXR cell adhesion molecule 1 S homeolog	Xenopus laevis	83-86
15733437-8	2004	After the addition of 10 mmol/L caffeine, 10 microg/L bFGF could not induce a significant increase of calcium.	Caffeine	32-40	fibroblast growth factor 2	Homo sapiens	54-58
15522167-2	2004	METHODS: We have established the model of decreased Cyclin E threshold in MOLT-4 cells by treating cells with low concentration (5 mmol/L) of caffeine for 2, and 4 h. The positive rates of proliferation cell nuclear antigen (PCNA), Ki67, and DNA strand break induction by photolysis (SBIP) were analyzed by flow cytometry.	Caffeine	142-150	proliferating cell nuclear antigen	Homo sapiens	52-58
15476664-4	2004	Caffeine also suppressed insulin-induced GLUT4 translocation in the differentiated cells.	Caffeine	0-8	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	41-46
15476664-5	2004	Although caffeine did not alter insulin-induced activation of PI3K and protein kinase C-zeta (PKCzeta), an isoform of atypical PKC, which is reported to have an important role in insulin-induced GLUT4 translocation, we found that insulin-induced phosphorylation and activation of Akt were blocked by pre-treatment with caffeine.	Caffeine	319-327	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	195-200
15522167-3	2004	RESULTS: MOLT-4 cells presented sharply decrease of Cyclin E threshold, and increase of positive rates of PCNA, Ki67, and SBIP after treated with caffeine, especially at 2-h point.	Caffeine	146-154	proliferating cell nuclear antigen	Homo sapiens	106-110
15284060-9	2004	Although selective Ca2+-activated K+ (KCa) channel blockers and intracellular Ca2+ release inhibitors induced only small constrictions at low and high pressures, a low concentration of caffeine (1 microM), a ryanodine-sensitive Ca2+ release (RyR) channel activator, increased KCa channel activity and induced dilation.	Caffeine	185-193	casein kappa	Homo sapiens	38-41
15485911-6	2004	Strains lacking YAF9 are sensitive to DNA-damaging agents, cold, and caffeine, and the YEATS domain is required for full Yaf9 function.	Caffeine	69-77	YEATS domain containing 4	Homo sapiens	16-20
15349845-3	2004	ESP13.2 and PSP94 constituted approximately 95% of the proteins released from the sperm surface following treatment with caffeine + dbcAMP.	Caffeine	121-129	microseminoprotein beta	Homo sapiens	12-17
15201305-0	2004	Caffeine releasable stores of Ca2+ show depletion prior to the final steps in delayed CA1 neuronal death.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	30-33
15201305-0	2004	Caffeine releasable stores of Ca2+ show depletion prior to the final steps in delayed CA1 neuronal death.	Caffeine	0-8	carbonic anhydrase 1	Homo sapiens	86-89
15201305-3	2004	Experiments here have assessed the relative content of ryanodine receptor-gated stores in CA1 neurons by measuring cytoplasmic Ca2+ increases induced by caffeine.	Caffeine	153-161	carbonic anhydrase 2	Homo sapiens	127-130
15328782-8	2004	Time to complete the sandbag piling task during set 1 was significantly reduced with caffeine (12.9 +/- 1.0 min) compared with placebo (13.8 +/- 1.0 min) but there was no difference during set 2 and RPE was increased.	Caffeine	85-93	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	48-53
15299003-6	2004	The functional impact on calcium release of RYR1 mutations linked to central core disease or malignant hyperthermia is different: human myotubes carrying the malignant hyperthermia-linked RYR1 mutation V2168M had a shift in their sensitivity to the RYR agonist 4-chloro-m-cresol to lower concentrations, whereas human myotubes harboring C-terminal mutations linked to central core disease exhibited reduced [Ca2+]i increase in response to 4-chloro-m-cresol, caffeine, and KCl.	Caffeine	458-466	ryanodine receptor 1	Homo sapiens	44-48
15299003-6	2004	The functional impact on calcium release of RYR1 mutations linked to central core disease or malignant hyperthermia is different: human myotubes carrying the malignant hyperthermia-linked RYR1 mutation V2168M had a shift in their sensitivity to the RYR agonist 4-chloro-m-cresol to lower concentrations, whereas human myotubes harboring C-terminal mutations linked to central core disease exhibited reduced [Ca2+]i increase in response to 4-chloro-m-cresol, caffeine, and KCl.	Caffeine	458-466	ryanodine receptor 1	Homo sapiens	188-192
15201141-10	2004	These results indicate that the R1086H MH mutation in alpha(1S) enhances RyR1 sensitivity to activation by both endogenous (voltage sensor) and exogenous (caffeine) activators.	Caffeine	155-163	ryanodine receptor 1	Homo sapiens	73-77
15313438-0	2004	Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.	Caffeine	0-8	tumor necrosis factor	Homo sapiens	20-29
15313438-8	2004	Moreover, the effect of caffeine on TNF-alpha production was abolished by pretreatment with the protein kinase A inhibitor Rp-8-Br-cAMPS (10(-4) and 10(-5)M).	Caffeine	24-32	tumor necrosis factor	Homo sapiens	36-45
15313438-9	2004	To conclude, this study demonstrates that concentrations of caffeine that are relevant to human consumption consistently suppress production of the proinflammatory cytokine TNF-alpha in human blood and that this effect is mediated by the cyclic AMP/protein kinase A pathway.	Caffeine	60-68	tumor necrosis factor	Homo sapiens	173-182
15465742-1	2004	Caffeine ingestion negatively affects insulin sensitivity during an oral glucose tolerance test (OGTT) in lean and obese men, but this has not been studied in individuals with type 2 diabetes.	Caffeine	0-8	insulin	Homo sapiens	38-45
15465742-2	2004	We examined the effects of caffeine ingestion on insulin and glucose homeostasis in obese men with type 2 diabetes.	Caffeine	27-35	insulin	Homo sapiens	49-56
15465742-6	2004	Caffeine increased (P &lt; 0.05) serum insulin, proinsulin, and C-peptide concentrations during the OGTT relative to placebo.	Caffeine	0-8	insulin	Homo sapiens	39-46
15465742-6	2004	Caffeine increased (P &lt; 0.05) serum insulin, proinsulin, and C-peptide concentrations during the OGTT relative to placebo.	Caffeine	0-8	insulin	Homo sapiens	48-58
15465742-6	2004	Caffeine increased (P &lt; 0.05) serum insulin, proinsulin, and C-peptide concentrations during the OGTT relative to placebo.	Caffeine	0-8	insulin	Homo sapiens	64-73
15465742-7	2004	Insulin area under the curve was 25% greater (P &lt; 0.05) after caffeine than after placebo ingestion.	Caffeine	65-73	insulin	Homo sapiens	0-7
15465742-10	2004	The insulin sensitivity index was lower (14%, P = 0.02) after caffeine than after placebo ingestion.	Caffeine	62-70	insulin	Homo sapiens	4-11
15350815-1	2004	In this investigation, we report the presence of cholinomimetic and acetylcholinesterase (AChE) inhibitory constituents in betel nut, the most commonly used drug in the world after tobacco, ethanol and caffeine.	Caffeine	202-210	ACE-1	Oryctolagus cuniculus	68-88
15350815-1	2004	In this investigation, we report the presence of cholinomimetic and acetylcholinesterase (AChE) inhibitory constituents in betel nut, the most commonly used drug in the world after tobacco, ethanol and caffeine.	Caffeine	202-210	ACE-1	Oryctolagus cuniculus	90-94
15229224-8	2004	The involvement of Nat3p and Tfs1p in PKA signaling was supported by caffeine growth inhibition studies.	Caffeine	69-77	peptide alpha-N-acetyltransferase complex B subunit NAT3	Saccharomyces cerevisiae S288C	19-24
15229224-8	2004	The involvement of Nat3p and Tfs1p in PKA signaling was supported by caffeine growth inhibition studies.	Caffeine	69-77	Tfs1p	Saccharomyces cerevisiae S288C	29-34
15517906-7	2004	We speculate that caffeine may enhance MOLT-4 cell entrance into the S-phase through activation of Cdc25, which in turn activates cyclin-dependent protein kinases (CDKs) including CDK2 and drives the cell cycle progression; while degradation of cyclin E by the ubiquitin/proteasome pathway may account for the decreased levels of cyclin E in these cells.	Caffeine	18-26	cell division cycle 25C	Homo sapiens	99-104
15517906-7	2004	We speculate that caffeine may enhance MOLT-4 cell entrance into the S-phase through activation of Cdc25, which in turn activates cyclin-dependent protein kinases (CDKs) including CDK2 and drives the cell cycle progression; while degradation of cyclin E by the ubiquitin/proteasome pathway may account for the decreased levels of cyclin E in these cells.	Caffeine	18-26	cyclin dependent kinase 2	Homo sapiens	164-168
15517906-7	2004	We speculate that caffeine may enhance MOLT-4 cell entrance into the S-phase through activation of Cdc25, which in turn activates cyclin-dependent protein kinases (CDKs) including CDK2 and drives the cell cycle progression; while degradation of cyclin E by the ubiquitin/proteasome pathway may account for the decreased levels of cyclin E in these cells.	Caffeine	18-26	cyclin dependent kinase 2	Homo sapiens	180-184
15464060-5	2004	The expression of ryanodine receptor-1 and ryanodine receptor-2 mRNA in MIN6 cells was confirmed using reverse transcription-polymerase chain reaction (RT-PCR) and, since low concentrations of caffeine (1 mM) or thimerosal (10 microM) stimulated increases in [Ca(2+)](i), we conclude that ryanodine receptors are functional in these cells.	Caffeine	193-201	ryanodine receptor 1, skeletal muscle	Mus musculus	18-63
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Caffeine	19-27	ATM serine/threonine kinase	Homo sapiens	83-86
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Caffeine	19-27	choline kinase alpha	Homo sapiens	91-94
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Caffeine	19-27	cytochrome c, somatic	Homo sapiens	273-285
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Caffeine	19-27	diablo IAP-binding mitochondrial protein	Homo sapiens	290-294
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Caffeine	19-27	diablo IAP-binding mitochondrial protein	Homo sapiens	295-301
15466201-5	2004	Sensitization to IR-induced apoptosis by caffeine or UCN-01 was abrogated neither by cycloheximide nor by pifithrin-alpha, an inhibitor of the transcriptional activity of p53.	Caffeine	41-49	tumor protein p53	Homo sapiens	171-174
15205451-7	2004	IL-1beta-induced reduction in caffeine-induced peak Ca(2+) increase and contraction was reversed by catalase, suggesting a role of H(2)O(2).	Caffeine	30-38	interleukin 1 beta	Homo sapiens	0-8
15296723-3	2004	Slowing follows caffeine-sensitive activation of the checkpoint kinase, Chk1; degradation of the cell cycle phosphatase, Cdc25A; and inhibitory phosphorylation of Cdc25C and cyclin-dependent kinases (Cdks).	Caffeine	16-24	ATR serine/threonine kinase L homeolog	Xenopus laevis	53-70
15296723-3	2004	Slowing follows caffeine-sensitive activation of the checkpoint kinase, Chk1; degradation of the cell cycle phosphatase, Cdc25A; and inhibitory phosphorylation of Cdc25C and cyclin-dependent kinases (Cdks).	Caffeine	16-24	checkpoint kinase 1 S homeolog	Xenopus laevis	72-76
15207706-0	2004	Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.	Caffeine	59-67	solute carrier family 22 member 6	Homo sapiens	24-51
15207706-3	2004	In this study the effect of caffeine and its main metabolites on the human organic anion transporter 1 (hOAT1) was investigated using CHO cells overexpressing hOAT1.	Caffeine	28-36	solute carrier family 22 member 6	Homo sapiens	75-102
15207706-3	2004	In this study the effect of caffeine and its main metabolites on the human organic anion transporter 1 (hOAT1) was investigated using CHO cells overexpressing hOAT1.	Caffeine	28-36	solute carrier family 22 member 6	Homo sapiens	104-109
15207706-3	2004	In this study the effect of caffeine and its main metabolites on the human organic anion transporter 1 (hOAT1) was investigated using CHO cells overexpressing hOAT1.	Caffeine	28-36	solute carrier family 22 member 6	Homo sapiens	159-164
15207706-7	2004	In conclusion, the caffeine metabolite 1-methylxanthine inhibits the transport activity of hOAT1 in vitro.	Caffeine	19-27	solute carrier family 22 member 6	Homo sapiens	91-96
15236952-8	2004	This review describes a case study involving the development of neonatal PBPK models for the CYP1A2 substrates caffeine and theophylline.	Caffeine	111-119	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99
15256477-0	2004	Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice.	Caffeine	45-53	transformation related protein 53, pseudogene	Mus musculus	99-102
15256477-0	2004	Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice.	Caffeine	45-53	BCL2-associated X protein	Mus musculus	107-110
15256477-3	2004	Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively.	Caffeine	24-32	transformation related protein 53, pseudogene	Mus musculus	77-80
15256477-3	2004	Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively.	Caffeine	24-32	transformation related protein 53, pseudogene	Mus musculus	89-92
15256477-6	2004	Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively.	Caffeine	23-31	BCL2-associated X protein	Mus musculus	65-68
15256477-6	2004	Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively.	Caffeine	23-31	BCL2-associated X protein	Mus musculus	77-80
15256477-6	2004	Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively.	Caffeine	23-31	BCL2-associated X protein	Mus musculus	77-80
15256477-6	2004	Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively.	Caffeine	23-31	BCL2-associated X protein	Mus musculus	77-80
15256477-6	2004	Topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradiation of Bax(+/+) or Bax(-/-) mice with UVB enhanced the UVB-induced increase in caspase 3 (active form) positive cells at 6 h by 253% and 750%, respectively.	Caffeine	23-31	caspase 3	Mus musculus	342-351
15256477-7	2004	The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways.	Caffeine	200-208	transformation related protein 53, pseudogene	Mus musculus	136-139
15256477-7	2004	The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways.	Caffeine	200-208	BCL2-associated X protein	Mus musculus	145-148
15256477-7	2004	The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways.	Caffeine	200-208	transformation related protein 53, pseudogene	Mus musculus	259-262
15256477-7	2004	The results indicate that UVB-induced increases in apoptosis in the epidermis of wild-type mice are predominantly (but not entirely) by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced increases in apoptosis by p53- and Bax-independent pathways.	Caffeine	200-208	BCL2-associated X protein	Mus musculus	268-271
15184059-2	2004	An arl1 Delta ccz1 Delta double mutant was viable but grew slowly, was more sensitive to caffeine, Ca(2+), Zn(2+), and hygromycin B than either single mutant, and had a more severe vacuolar protein sorting phenotype.	Caffeine	89-97	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	3-7
15123715-0	2004	Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.	Caffeine	89-97	ATR serine/threonine kinase L homeolog	Xenopus laevis	109-112
15123715-9	2004	We propose that a caffeine-sensitive, ATR-dependent checkpoint adjusts the frequency of initiation to the supply of replication factors and optimizes fork density for safe and efficient chromosomal replication during normal S phase.	Caffeine	18-26	ATR serine/threonine kinase L homeolog	Xenopus laevis	38-41
15177184-6	2004	The protein kinase activity of ATM was selectively inhibited by wortmannin, caffeine and LY294002 and was stimulated by charged biological polymers, including single-stranded M13 DNA (ssDNA), sheared double-stranded calf thymus DNA, heparin sulfate and poly ADP-ribose (PAR), raising the possibility that charged structures may contribute to regulation of ATM activity.	Caffeine	76-84	ATM serine/threonine kinase	Bos taurus	31-34
15184059-2	2004	An arl1 Delta ccz1 Delta double mutant was viable but grew slowly, was more sensitive to caffeine, Ca(2+), Zn(2+), and hygromycin B than either single mutant, and had a more severe vacuolar protein sorting phenotype.	Caffeine	89-97	Ccz1p	Saccharomyces cerevisiae S288C	14-18
15220931-4	2004	Inhibition of ATM and ATR with caffeine or specific neutralizing antibodies, or upregulation of Cdk2 or Cdc7, promoted rapid and synchronous origin firing; conversely, inhibition of Cdc25A slowed DNA replication.	Caffeine	31-39	ATM serine/threonine kinase	Homo sapiens	14-17
15262732-12	2004	The discovery that MR-1 mutations underlie PDC provides opportunities to explore this condition"s pathophysiologic characteristics and may provide insight into the causes of other paroxysmal neurologic disorders as well as the neurophysiologic mechanisms of alcohol and caffeine, which frequently precipitate PDC attacks.	Caffeine	270-278	major histocompatibility complex, class I-related	Homo sapiens	19-23
15213023-0	2004	Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss.	Caffeine	0-8	insulin	Homo sapiens	33-40
15213023-1	2004	BACKGROUND: Caffeine ingestion decreases the insulin sensitivity index (ISI) for an oral-glucose-tolerance test (OGTT) and decreases insulin-induced glucose disposal in lean male subjects during a hyperinsulinemic clamp.	Caffeine	12-20	insulin	Homo sapiens	45-52
15213023-2	2004	OBJECTIVE: We examined the effects of caffeine ingestion on insulin and glucose homeostasis in obese men before and after a nutrition and exercise intervention.	Caffeine	38-46	insulin	Homo sapiens	60-67
15213023-7	2004	Caffeine caused a greater (P &lt; or = 0.05) OGTT insulin response and a lower (P &lt; or = 0.05) ISI both before and after weight loss.	Caffeine	0-8	insulin	Homo sapiens	50-57
15213023-10	2004	The results are consistent with previous findings that caffeine ingestion contributes to insulin resistance.	Caffeine	55-63	insulin	Homo sapiens	89-96
15220931-4	2004	Inhibition of ATM and ATR with caffeine or specific neutralizing antibodies, or upregulation of Cdk2 or Cdc7, promoted rapid and synchronous origin firing; conversely, inhibition of Cdc25A slowed DNA replication.	Caffeine	31-39	ATR serine/threonine kinase	Homo sapiens	22-25
15110095-5	2004	Urinary caffeine metabolite ratios were significantly different between the two NAT2 genotypes, whereas for CYP1A2, the apparent difference in metabolic ratios between the genotypes was statistically non-significant.	Caffeine	8-16	N-acetyltransferase 2	Homo sapiens	80-84
15102855-4	2004	Although the IR-triggered degradation of Cdt1 was caffeine-insensitive, the UV-triggered degradation of Cdt1 was caffeine-sensitive.	Caffeine	50-58	chromatin licensing and DNA replication factor 1	Homo sapiens	41-45
15102855-4	2004	Although the IR-triggered degradation of Cdt1 was caffeine-insensitive, the UV-triggered degradation of Cdt1 was caffeine-sensitive.	Caffeine	113-121	chromatin licensing and DNA replication factor 1	Homo sapiens	104-108
15202999-8	2004	Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-expressing cells shows that these two sets of neurons mediate distinct taste modalities-the perception of bitter (caffeine) and sweet (trehalose) taste, respectively.	Caffeine	178-186	Gustatory receptor 66a	Drosophila melanogaster	49-54
15202999-8	2004	Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-expressing cells shows that these two sets of neurons mediate distinct taste modalities-the perception of bitter (caffeine) and sweet (trehalose) taste, respectively.	Caffeine	178-186	Gustatory receptor 5a	Drosophila melanogaster	59-63
15273831-2	2004	The visual evoked potential, specially the P300 component, has been used in studies that explain the stimulant mechanisms of caffeine through neurophysiological methods.	Caffeine	125-133	E1A binding protein p300	Homo sapiens	43-47
15473317-2	2004	Our results indicated that though human ELP4 was not able to complement the growth defects of the ELP4 deletion mutant strain to high concentration salt, it partially reduced the sensitivity of mutant strain to caffeine, high temperature and 6-AU.	Caffeine	211-219	elongator acetyltransferase complex subunit 4	Homo sapiens	40-44
14976127-4	2004	The aim of this population-based case-control study was to investigate if CYP1A2 or NAT2 activity measured as a ratio of urinary metabolites of dietary caffeine is a risk factor in testicular cancer.	Caffeine	152-160	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	74-80
14976127-4	2004	The aim of this population-based case-control study was to investigate if CYP1A2 or NAT2 activity measured as a ratio of urinary metabolites of dietary caffeine is a risk factor in testicular cancer.	Caffeine	152-160	N-acetyltransferase 2	Homo sapiens	84-88
15081797-2	2004	We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)).	Caffeine	127-135	adenosine A1 receptor	Mus musculus	64-67
15157940-0	2004	Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta.	Caffeine	0-8	BCL2 apoptosis regulator	Homo sapiens	42-47
15157940-3	2004	We found that the expression of the B-cell CLL/lymphoma 2 (Bcl-2) gene in BeWo cells was down-regulated by caffeine, suggesting that chronic exposure during the gestational period could exert an influence on embryogenesis.	Caffeine	107-115	BCL2 apoptosis regulator	Homo sapiens	36-57
15157940-3	2004	We found that the expression of the B-cell CLL/lymphoma 2 (Bcl-2) gene in BeWo cells was down-regulated by caffeine, suggesting that chronic exposure during the gestational period could exert an influence on embryogenesis.	Caffeine	107-115	BCL2 apoptosis regulator	Homo sapiens	59-64
15157940-5	2004	We found a significantly decreased level of Bcl-2 mRNA expression, which demonstrated the influence of caffeine on placental function.	Caffeine	103-111	BCL2 apoptosis regulator	Homo sapiens	44-49
15047862-4	2004	Expression of eGFP-tagged RyR constructs encoding distinct transmembrane topological models profoundly altered intracellular Ca(2+) handling and was refractory to modulation by ryanodine, FKBP12.6 and caffeine.	Caffeine	201-209	ryanodine receptor 2	Homo sapiens	26-29
15169897-4	2004	The increase in p53 expression and the G(1) phase arrest could be blocked by caffeine, an inhibitor of ATR.	Caffeine	77-85	tumor protein p53	Homo sapiens	16-19
15169897-4	2004	The increase in p53 expression and the G(1) phase arrest could be blocked by caffeine, an inhibitor of ATR.	Caffeine	77-85	ATR serine/threonine kinase	Homo sapiens	103-106
15081797-1	2004	Caffeine has biphasic effects on locomotion, and blockade of the adenosine A(2A) receptor (A2AR) is necessary for the stimulatory effect of low doses of caffeine, but not for the locomotor depressant effect observed at high doses.	Caffeine	153-161	adenosine A2a receptor	Mus musculus	65-89
15081797-3	2004	Caffeine had the typical biphasic dose-effect relationship in all three genotypes, but the stimulatory action of caffeine was facilitated in the A1R(KO) mice.	Caffeine	113-121	adenosine A1 receptor	Mus musculus	145-148
15081797-1	2004	Caffeine has biphasic effects on locomotion, and blockade of the adenosine A(2A) receptor (A2AR) is necessary for the stimulatory effect of low doses of caffeine, but not for the locomotor depressant effect observed at high doses.	Caffeine	153-161	adenosine A2a receptor	Mus musculus	91-95
15081797-2	2004	We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice heterozygous for (A1R(HET)), and mice lacking the adenosine A(1) receptor (A1R(KO)).	Caffeine	127-135	adenosine A1 receptor	Mus musculus	39-62
15081797-6	2004	As expected, the A1R is not crucial for the stimulatory effect of caffeine, but seems to modulate the effect of caffeine exerted via A2AR blockade.	Caffeine	112-120	adenosine A1 receptor	Mus musculus	17-20
15081797-6	2004	As expected, the A1R is not crucial for the stimulatory effect of caffeine, but seems to modulate the effect of caffeine exerted via A2AR blockade.	Caffeine	112-120	adenosine A2a receptor	Mus musculus	133-137
15126379-7	2004	Caffeine inhibited phosphorylation of retinoblastoma protein at Ser780 and Ser807/Ser811, the sites where retinoblastoma protein has been reported to be phosphorylated by cyclin-dependent kinase 4 (cdk4).	Caffeine	0-8	cyclin dependent kinase 4	Homo sapiens	171-196
14985349-6	2004	In control and mdx duodenal myocytes, both caffeine- and depolarization-induced calcium responses were dose-dependently and specifically inhibited with the anti-type 2 ryanodine receptor antibody.	Caffeine	43-51	ryanodine receptor 2, cardiac	Mus musculus	161-186
15126379-7	2004	Caffeine inhibited phosphorylation of retinoblastoma protein at Ser780 and Ser807/Ser811, the sites where retinoblastoma protein has been reported to be phosphorylated by cyclin-dependent kinase 4 (cdk4).	Caffeine	0-8	cyclin dependent kinase 4	Homo sapiens	198-202
15126379-8	2004	Furthermore, caffeine inhibited the activation of the cyclin D1-cdk4 complex in a dose-dependent manner.	Caffeine	13-21	cyclin D1	Homo sapiens	54-63
15126379-8	2004	Furthermore, caffeine inhibited the activation of the cyclin D1-cdk4 complex in a dose-dependent manner.	Caffeine	13-21	cyclin dependent kinase 4	Homo sapiens	64-68
15126379-10	2004	In addition, caffeine did not affect p16INK4 or p27Kip1 protein levels, but inhibited the phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3beta.	Caffeine	13-21	AKT serine/threonine kinase 1	Homo sapiens	127-130
15126379-10	2004	In addition, caffeine did not affect p16INK4 or p27Kip1 protein levels, but inhibited the phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3beta.	Caffeine	13-21	glycogen synthase kinase 3 beta	Homo sapiens	136-166
15086516-6	2004	A similar effect was observed when cells were treated with pharmacological agents that directly manipulate the levels of intracellular calcium (caffeine and the calcium ionophore A23187), suggesting that the increased levels of calsenilin in the nucleus are mediated by changes in intracellular calcium.	Caffeine	144-152	potassium voltage-gated channel interacting protein 3	Homo sapiens	228-238
14966299-4	2004	The amplitude of caffeine-induced Ca(2+) release was also greater, indicating a higher SR Ca(2+) content in the Ad-FKBP12.6 group.	Caffeine	17-25	peptidyl-prolyl cis-trans isomerase FKBP1B	Oryctolagus cuniculus	112-123
15269663-17	2004	Functional studies of the RYR1 mutations have shown that MHS mutations were mainly associated with an alteration of the calcium fluxes in response to caffeine or halothane while CCD mutations would result in a leaky RYR1 channel or would alter the Excitation-Contraction coupling at the level of the CMC.	Caffeine	150-158	ryanodine receptor 1	Homo sapiens	26-30
15060505-7	2004	RESULTS: Ephedrine plus caffeine increased systolic blood pressure (peak difference, 11.7 +/- 9.4 mm Hg; compared with placebo, P =.0005) and heart rate (peak difference, 5.9 +/- 8.8 beats/min; compared with placebo, P =.001) and raised fasting glucose, insulin, free fatty acid, and lactate concentrations.	Caffeine	24-32	insulin	Homo sapiens	254-261
14988409-6	2004	Each of these agents also triggered S-phase checkpoint activation in parental ES cells, as indicated by a caffeine-inhibitable decrease in [3H]thymidine incorporation into DNA and Cdc25A down-regulation.	Caffeine	106-114	cell division cycle 25A	Homo sapiens	180-186
14744854-6	2004	In cells treated with caffeine, an inhibitor of ATM, HRR was reduced, whereas NHEJ was not.	Caffeine	22-30	ATM serine/threonine kinase	Homo sapiens	48-51
14744854-7	2004	In support of this finding, GFP flow cytometry demonstrated that caffeine reduced HRR by 90% under conditions when ATM kinase activity was inhibited.	Caffeine	65-73	ATM serine/threonine kinase	Homo sapiens	115-118
14744854-9	2004	Furthermore, HRR was inhibited by caffeine in serum-starved cells arrested in G(0)/G(1), suggesting that ATM is also important for HRR outside of the S and G(2) cell cycle phases.	Caffeine	34-42	ATM serine/threonine kinase	Homo sapiens	105-108
15081811-6	2004	HEK293 cells expressing RyR2(T1366-GFP) cDNAs showed caffeine-sensitive and ryanodine-sensitive calcium release, demonstrating that RyR2(T1366-GFP) forms functional calcium release channels.	Caffeine	53-61	ryanodine receptor 2	Homo sapiens	24-28
15081811-6	2004	HEK293 cells expressing RyR2(T1366-GFP) cDNAs showed caffeine-sensitive and ryanodine-sensitive calcium release, demonstrating that RyR2(T1366-GFP) forms functional calcium release channels.	Caffeine	53-61	ryanodine receptor 2	Homo sapiens	132-136
15044622-6	2004	Other adenosine receptor ligands, including caffeine, bound better to hCNT1 than to hCNT2 (K(i) = 46 versus 103 microM, respectively), whereas 2-chloroadenosine bound better to hCNT2 than to hCNT1 (K(i) = 37 and 101 microM, respectively).	Caffeine	44-52	solute carrier family 28 member 1	Homo sapiens	70-75
15078556-8	2004	Antidepressants and caffeine activated ERK in hippocampus and cerebral cortex.	Caffeine	20-28	mitogen-activated protein kinase 1	Mus musculus	39-42
15206669-4	2004	These patients were confirmed as being CYP1A2 ultrarapid metabolizers by the caffeine phenotyping test (median systemic caffeine plasma clearance; range, 3.85; 3.33 to 4.17 mL/min/kg) when compared with previous studies (0.3 to 3.33 mL/min/kg).	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
15044622-6	2004	Other adenosine receptor ligands, including caffeine, bound better to hCNT1 than to hCNT2 (K(i) = 46 versus 103 microM, respectively), whereas 2-chloroadenosine bound better to hCNT2 than to hCNT1 (K(i) = 37 and 101 microM, respectively).	Caffeine	44-52	solute carrier family 28 member 2	Homo sapiens	84-89
15044622-6	2004	Other adenosine receptor ligands, including caffeine, bound better to hCNT1 than to hCNT2 (K(i) = 46 versus 103 microM, respectively), whereas 2-chloroadenosine bound better to hCNT2 than to hCNT1 (K(i) = 37 and 101 microM, respectively).	Caffeine	44-52	solute carrier family 28 member 1	Homo sapiens	191-196
14970260-4	2004	Caffeine-induced 45Ca(2+)-efflux was markedly increased in cells expressing mutant type-3 ryanodine receptor whereas the maximal-releasable Ca2+ was not affected.	Caffeine	0-8	ryanodine receptor 3	Homo sapiens	83-108
15060176-0	2004	Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.	Caffeine	96-104	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	28-56
15060176-0	2004	Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.	Caffeine	96-104	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	58-64
15060176-1	2004	Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR).	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	184-213
15060176-1	2004	Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR).	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	215-218
15060176-1	2004	Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR).	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	224-251
15060176-4	2004	In this report we demonstrate that the camptothecin-induced phosphorylation of RPA32 on Thr21 is inhibited by 2 mM caffeine.	Caffeine	115-123	replication protein A2	Homo sapiens	79-84
15060176-5	2004	In addition, we show that caffeine inhibits immunoprecipitated and purified DNA-PK, as well as DNA-PK in cell extracts, with an IC50 of 0.2-0.6 mM.	Caffeine	26-34	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	76-82
15060176-5	2004	In addition, we show that caffeine inhibits immunoprecipitated and purified DNA-PK, as well as DNA-PK in cell extracts, with an IC50 of 0.2-0.6 mM.	Caffeine	26-34	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	95-101
15060176-6	2004	Caffeine inhibited DNA-PK activity through a mixed non-competitive mechanism with respect to ATP.	Caffeine	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	19-25
15060176-7	2004	In contrast, 10-fold higher concentrations of caffeine were required to inhibit DNA-PK autophosphorylation in vitro and caffeine failed to inhibit DNA-PKcs dependent double-strand break repair in vivo.	Caffeine	46-54	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	80-86
14747882-1	2004	BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence.	Caffeine	164-172	N-acetyltransferase 2	Homo sapiens	77-108
14747882-1	2004	BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence.	Caffeine	164-172	N-acetyltransferase 2	Homo sapiens	110-114
14747882-6	2004	RESULTS: The urinary NAT2 ratios (AFMU+AAMU) / (AFMU+AAMU+1X+1U) before and after caffeine intake correlated well in 65 volunteers (r(2)=0.827; P&lt; 0.0001).	Caffeine	82-90	N-acetyltransferase 2	Homo sapiens	21-25
14747882-9	2004	CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS.	Caffeine	113-121	N-acetyltransferase 2	Homo sapiens	12-16
14747882-9	2004	CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS.	Caffeine	172-180	N-acetyltransferase 2	Homo sapiens	12-16
15039113-4	2004	In addition, it was shown that BAPTA-AM treatment inhibits caffeine-induced increase of caspase-3 enzyme activity.	Caffeine	59-67	caspase 3	Homo sapiens	88-97
15039113-5	2004	These results show that caffeine induces apoptotic death in human SK-N-MC neuroblastoma cells and BAPTA-AM prevents apoptosis by attenuating caffeine-induced caspase-3 activation.	Caffeine	141-149	caspase 3	Homo sapiens	158-167
14592807-6	2004	Control cells showed no significant response to cold or caffeine, whereas robust Ca2+ transients were recorded in response to both RC and caffeine in transduced cells expressing any one of the three RyR isoforms.	Caffeine	138-146	ryanodine receptor 1	Homo sapiens	199-202
14747882-0	2004	Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.	Caffeine	45-53	N-acetyltransferase 2	Homo sapiens	15-41
14747882-1	2004	BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence.	Caffeine	129-137	N-acetyltransferase 2	Homo sapiens	77-108
14747882-1	2004	BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence.	Caffeine	129-137	N-acetyltransferase 2	Homo sapiens	110-114
14969283-7	2004	For caffeine, the AEDs converge to a bimodal and a quadrimodal distribution on XTerra MS-C18 and Resolve-C18, respectively.	Caffeine	4-12	Bardet-Biedl syndrome 9	Homo sapiens	89-92
15009670-3	2004	In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellular levels of dopamine and glutamate in the shell of the rat nucleus accumbens (NAc) and counteracted both dopamine and glutamate release induced by systemic administration of motor-activating doses of either the A1 receptor antagonist CPT or caffeine.	Caffeine	392-400	msh homeobox 3	Rattus norvegicus	109-114
15359622-4	2004	CYP1A2 activity was evaluated by the plasma paraxanthine/caffeine (PAX/CAF) metabolic ratio.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
14969283-17	2004	As for caffeine, the high-energy sites are definitely located within the C18-bonded layer, not on the bare surface of the adsorbent.	Caffeine	7-15	Bardet-Biedl syndrome 9	Homo sapiens	73-76
14713563-6	2004	The current analysis utilizes data for caffeine and theophylline, closely related xanthines that are both cytochrome P-450 (CYP) 1A2 substrates, in developing PBPK models for neonates and adults.	Caffeine	39-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	106-132
14751246-1	2004	Caffeine has been widely described as a chemo/radiosensitizing agent, presumably by inhibiting DNA repair, and affecting preferentially cells with an altered p53 status.	Caffeine	0-8	tumor protein p53	Homo sapiens	158-161
14716295-5	2004	The G2 arrest in response to these drugs were sensitive to caffeine, suggesting that ATM/ATR signalling in these checkpoint responses may be blocked by the EBNA-3 family proteins.	Caffeine	59-67	ATM serine/threonine kinase	Homo sapiens	85-88
14716295-5	2004	The G2 arrest in response to these drugs were sensitive to caffeine, suggesting that ATM/ATR signalling in these checkpoint responses may be blocked by the EBNA-3 family proteins.	Caffeine	59-67	ATR serine/threonine kinase	Homo sapiens	89-92
14969283-7	2004	For caffeine, the AEDs converge to a bimodal and a quadrimodal distribution on XTerra MS-C18 and Resolve-C18, respectively.	Caffeine	4-12	Bardet-Biedl syndrome 9	Homo sapiens	105-108
14969283-12	2004	Possible hydrogen-bond interactions between caffeine and the non-protected isolated silanol groups remaining after synthesis amidst the C18-chain network cannot explain these high energy interactions because, then, the smaller phenol molecule should exhibit similarly strong interactions with these isolated silanols on the same Resolve-C18 column and, yet, the consequences of such interactions are not observed.	Caffeine	44-52	Bardet-Biedl syndrome 9	Homo sapiens	136-139
14570700-6	2004	PGC-1alpha content in EPI was increased after 18-h in vitro incubation with 0.5 mM 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 4 mM caffeine.	Caffeine	146-154	PPARG coactivator 1 alpha	Rattus norvegicus	0-10
14757171-7	2004	Caffeine, an ATM kinase inhibitor, inhibited these effects of genistein on Chk2, p53, and p21waf1/cip1.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	13-16
14757171-7	2004	Caffeine, an ATM kinase inhibitor, inhibited these effects of genistein on Chk2, p53, and p21waf1/cip1.	Caffeine	0-8	checkpoint kinase 2	Homo sapiens	75-79
14757171-7	2004	Caffeine, an ATM kinase inhibitor, inhibited these effects of genistein on Chk2, p53, and p21waf1/cip1.	Caffeine	0-8	tumor protein p53	Homo sapiens	81-84
14757171-7	2004	Caffeine, an ATM kinase inhibitor, inhibited these effects of genistein on Chk2, p53, and p21waf1/cip1.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-102
15013152-5	2004	Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131
15020461-7	2004	Overexpression of SIW14 also rescued the caffeine sensitivity of the slt2 mutant isolated in the screen, but this was not due to alteration of the phosphorylation state of Slt2.	Caffeine	41-49	putative tyrosine protein phosphatase SIW14	Saccharomyces cerevisiae S288C	18-23
14570591-2	2004	Yeast cells with the Hsp 12 gene disrupted were unable to grow in the presence of either 12 mM caffeine or 0.43 mM Congo Red, molecules known to affect cell-wall integrity.	Caffeine	95-103	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	21-27
14960625-8	2004	Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	29-33
14960625-8	2004	Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	160-164
14706290-8	2004	The depolarization-, caffeine- and 4-chloro-m-cresol (4-CmC)-induced Ca2+ transients in these cells were dramatically reduced compared with cells expressing wild type RyR1.	Caffeine	21-29	ryanodine receptor 1	Homo sapiens	167-171
15020461-7	2004	Overexpression of SIW14 also rescued the caffeine sensitivity of the slt2 mutant isolated in the screen, but this was not due to alteration of the phosphorylation state of Slt2.	Caffeine	41-49	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	69-73
14743382-6	2004	When their DNA is damaged, p53-defective tumor cells preferentially arrest in S or G2 phase where they are susceptible to checkpoint inhibitors such as caffeine and UCN-01.	Caffeine	152-160	tumor protein p53	Homo sapiens	27-30
14702388-9	2004	The DNA synthesis inhibitor aphidicolin caused a nearly complete loss of nuclear YY1, whereas addition of caffeine or 2-aminopurine to aphidicolin-treated cells restored both DNA synthesis and YY1 localization in the nucleus.	Caffeine	106-114	YY1 transcription factor	Homo sapiens	193-196
14729972-7	2004	Moreover, BS cells ectopically expressing a BLM protein containing phosphorylation-resistant T99A/T122A substitutions fail to adequately recover from an HU-induced replication blockade, and the cells subsequently arrest at a caffeine-sensitive G(2)/M checkpoint.	Caffeine	225-233	BLM RecQ like helicase	Homo sapiens	44-47
14593104-3	2004	In the present study, we have systematically investigated the effects of mutations of each residue within the 24-amino acid TM10 sequence of the mouse cardiac ryanodine receptor (RyR2) on channel activation by caffeine and Ca(2+).	Caffeine	210-218	ryanodine receptor 2	Homo sapiens	159-177
14593104-3	2004	In the present study, we have systematically investigated the effects of mutations of each residue within the 24-amino acid TM10 sequence of the mouse cardiac ryanodine receptor (RyR2) on channel activation by caffeine and Ca(2+).	Caffeine	210-218	ryanodine receptor 2, cardiac	Mus musculus	179-183
14593104-4	2004	Intracellular Ca(2+) release measurements in human embryonic kidney 293 cells expressing the RyR2 wild type and TM10 mutants revealed that several mutations in the TM10 sequence either abolished caffeine response or markedly reduced the sensitivity of the RyR2 channel to activation by caffeine.	Caffeine	195-203	ryanodine receptor 2	Homo sapiens	93-97
13679303-6	2004	These results suggest the presence of an interaction between RyR1 and the DHPR, which is not present in RyR2, that contributes negative control of SR Ca2+ release induced by direct agonists such as caffeine.	Caffeine	198-206	ryanodine receptor 1	Homo sapiens	61-65
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	155-163	DNA repair protein RAD51 homolog 1	Cricetulus griseus	71-76
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	155-163	DNA repair protein XRCC2	Cricetulus griseus	86-91
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	155-163	DNA repair protein XRCC3	Cricetulus griseus	96-101
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	268-276	DNA repair protein RAD51 homolog 1	Cricetulus griseus	71-76
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	268-276	DNA repair protein XRCC2	Cricetulus griseus	86-91
14737117-1	2004	We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand breaks (DSBs) in the mechanism of caffeine radiosensitization.	Caffeine	268-276	DNA repair protein XRCC3	Cricetulus griseus	96-101
14737117-6	2004	Recombination events occurring during treatment with caffeine are characterized by rearrangements reminiscent to those previously reported for the XRCC3 mutant, and immunofluorescence microscopy demonstrates significantly reduced formation of IR-specific RAD51 foci after caffeine treatment.	Caffeine	53-61	DNA repair protein XRCC3	Cricetulus griseus	147-152
14737117-6	2004	Recombination events occurring during treatment with caffeine are characterized by rearrangements reminiscent to those previously reported for the XRCC3 mutant, and immunofluorescence microscopy demonstrates significantly reduced formation of IR-specific RAD51 foci after caffeine treatment.	Caffeine	53-61	DNA repair protein RAD51 homolog 1	Cricetulus griseus	255-260
12958030-3	2004	Sorcin is an EF-hand protein that confers the property of caffeine-activated intracellular Ca(2+) release in nonmuscle cells by interacting with RyR2.	Caffeine	58-66	sorcin	Rattus norvegicus	0-6
12958030-3	2004	Sorcin is an EF-hand protein that confers the property of caffeine-activated intracellular Ca(2+) release in nonmuscle cells by interacting with RyR2.	Caffeine	58-66	ryanodine receptor 2	Rattus norvegicus	145-149
12959929-10	2004	We also show that checkpoint kinase 1 (Chk1) is phosphorylated on Ser345 in response to hyperoxia, which could be inhibited by caffeine or wortmannin, potent inhibitors of phosphoinositide 3-kinase-related kinases.	Caffeine	127-135	checkpoint kinase 1	Homo sapiens	18-37
13679303-6	2004	These results suggest the presence of an interaction between RyR1 and the DHPR, which is not present in RyR2, that contributes negative control of SR Ca2+ release induced by direct agonists such as caffeine.	Caffeine	198-206	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	74-78
12959929-10	2004	We also show that checkpoint kinase 1 (Chk1) is phosphorylated on Ser345 in response to hyperoxia, which could be inhibited by caffeine or wortmannin, potent inhibitors of phosphoinositide 3-kinase-related kinases.	Caffeine	127-135	checkpoint kinase 1	Homo sapiens	39-43
14634821-1	2004	Previous studies have shown that ryanodine in low concentrations and caffeine increase intracellular [Ca(2+)] in the absence of external Ca(2+), suggesting Ca(2+) release from intracellular stores through ryanodine receptors (RyR).	Caffeine	69-77	ryanodine receptor 2	Homo sapiens	205-224
14725610-1	2004	Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme.	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	53-71
14725610-1	2004	Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme.	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	73-79
14725610-12	2004	The increase in serum clozapine concentration was most likely due to the inhibition of the CYP1A2 enzyme by caffeine.	Caffeine	108-116	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-97
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	fibulin 1	Homo sapiens	213-218
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	biglycan	Homo sapiens	220-223
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	secreted protein acidic and cysteine rich	Homo sapiens	225-230
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	fibrillin 1	Homo sapiens	232-236
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	lysyl oxidase like 1	Homo sapiens	238-243
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	collagen type III alpha 1 chain	Homo sapiens	253-259
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	collagen type V alpha 1 chain	Homo sapiens	261-267
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	collagen type VI alpha 1 chain	Homo sapiens	286-292
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	collagen type VI alpha 2 chain	Homo sapiens	294-300
16035617-7	2004	Gene and protein expression patterns resulting from caffeine treatment showed that metastasis suppression may be associated with up-regulation the mRNA expression of multiple extracellular matrix genes, including Fbln1, Bgn, Sparc, Fbn1, Loxl1, Colla1, Col3a1, Col5a1, ColS5a2, ColSa3, Col6a1, Col6a2, and Col6a3.	Caffeine	52-60	collagen type VI alpha 3 chain	Homo sapiens	306-312
15027815-2	2004	Here, a mixture of ketoconazole, isoniazid and caffeine (inhibitor solution), known inhibitors of CYP3A, CYP2E1 and CYP1A2, was investigated for prevention of hepatotoxicity after paracetamol over-dose in rats.	Caffeine	47-55	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	105-111
15027815-2	2004	Here, a mixture of ketoconazole, isoniazid and caffeine (inhibitor solution), known inhibitors of CYP3A, CYP2E1 and CYP1A2, was investigated for prevention of hepatotoxicity after paracetamol over-dose in rats.	Caffeine	47-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	116-122
15456933-0	2004	Caffeine induces sonic hedgehog gene expression in cultured astrocytes and neurons.	Caffeine	0-8	sonic hedgehog	Mus musculus	17-31
15456933-2	2004	In this model, caffeine induces the expression of the regulatory subunit alpha of protein kinase A (PKA RI alpha) and of Sonic hedgehog (Shh).	Caffeine	15-23	sonic hedgehog	Mus musculus	121-135
15456933-2	2004	In this model, caffeine induces the expression of the regulatory subunit alpha of protein kinase A (PKA RI alpha) and of Sonic hedgehog (Shh).	Caffeine	15-23	sonic hedgehog	Mus musculus	137-140
15456933-5	2004	Using real-time PCR, the results showed that caffeine induced robust overexpression of Shh mRNA in both cell types without significantly modifying PKA RI alpha gene expression.	Caffeine	45-53	sonic hedgehog	Mus musculus	87-90
15217501-4	2004	In vivo CYP1A2 activity was assessed by measuring caffeine metabolites in urine.	Caffeine	50-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
15217502-2	2004	Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.	Caffeine	116-124	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19
15217502-2	2004	Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.	Caffeine	116-124	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
15217502-5	2004	In vivo CYP1A2 activity was assessed by measuring caffeine metabolites in urine.	Caffeine	50-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
15217502-8	2004	In premenopausal women, CYP1A2 activity was also positively related to insulin levels, caffeine intake, age, and plasma triglyceride levels, and negatively related with total cholesterol levels and body mass index.	Caffeine	87-95	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-30
15663294-1	2004	The use of caffeine as a probe for CYP1A2 phenotyping has been extensively investigated over the last 25 years.	Caffeine	11-19	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	35-41
21782683-1	2004	Caffeine (CAF), a widely used and extensively studied chemical, is known for the reports on its controversial and inconsistent genotoxic effects, potentiative and protective effects from the genotoxicity of chemical and physical mutagens, and its modulatory effects on the action of antineoplastic drugs.	Caffeine	0-8	caffeine susceptibility	Mus musculus	10-13
14634821-1	2004	Previous studies have shown that ryanodine in low concentrations and caffeine increase intracellular [Ca(2+)] in the absence of external Ca(2+), suggesting Ca(2+) release from intracellular stores through ryanodine receptors (RyR).	Caffeine	69-77	ryanodine receptor 2	Homo sapiens	226-229
15012901-11	2003	We suggest that although CYP2E1 is expressed in the tongue, it is rapidly degraded in this organ, and the nitrophenol hydroxylation and caffeine hydroxylation we observe is the result of activity of CYP1A1.	Caffeine	136-144	cytochrome P450 2E1	Oryctolagus cuniculus	25-31
14600284-3	2004	PCB 95 sensitization of RyR-mediated responses was further supported by the observations that ryanodine pretreatment blocked response to caffeine and coplanar 2,4,4",5-tetrachlorobiphenyl (PCB 66), which lacks RyR activity, failed to sensitize neurons.	Caffeine	137-145	ryanodine receptor 1	Homo sapiens	24-27
14557272-8	2003	Single channel analyses revealed that mutation Q4863A dramatically altered the kinetics and apparent affinity of ryanodine interaction with single RyR2 channels and abolished the effect of ryanodol, an analogue of ryanodine, whereas the single channel conductance of the Q4863A mutant and its responses to caffeine, ATP, and Mg2+ were comparable to those of the wild type channels.	Caffeine	306-314	ryanodine receptor 2	Homo sapiens	147-151
14663012-2	2003	The authors review the evidence that caffeine and more specific antagonists of the adenosine A2A receptor protect dopaminergic neurons in several toxin models of PD.	Caffeine	37-45	adenosine A2a receptor	Homo sapiens	83-105
14653948-6	2003	When the cardiac myocytes were exposed to caffeine (100 mmol/L) for 30 min, TNF-alpha failed to induce any change of intracellular free calcium.	Caffeine	42-50	tumor necrosis factor	Rattus norvegicus	76-85
14616429-0	2003	Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.	Caffeine	11-19	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	82-88
14616429-1	2003	AIMS: The aim of this study was to assess the influence of concomitant caffeine intake on the pharmacokinetics of oral melatonin, a probe drug for CYP1A2 activity.	Caffeine	71-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	147-153
14616429-7	2003	CONCLUSION: The results of this study revealed a pronounced effect of caffeine on the bioavailability of orally given melatonin, most probably due to inhibition of CYP1A2 activity.	Caffeine	70-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	164-170
14623768-7	2003	Caffeine (10 mm), SKF 96165 (30 microm) or U73122 (5 microm) together with nifedipine (1 microm) abolished ET-1-induced vasospasm and increase in [Ca2+]i.	Caffeine	0-8	endothelin-1	Cavia porcellus	107-111
14652086-0	2003	The alerting effects of caffeine, bright light and face washing after a short daytime nap.	Caffeine	24-32	catenin beta like 1	Homo sapiens	86-89
14652086-8	2003	CONCLUSIONS: The effects of a short nap against mid-afternoon sleepiness could be enhanced by combining caffeine intake, exposure to bright light, or face washing.	Caffeine	104-112	catenin beta like 1	Homo sapiens	36-39
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	ATM serine/threonine kinase	Homo sapiens	18-21
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	ATR serine/threonine kinase	Homo sapiens	22-25
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	mitogen-activated protein kinase 14	Homo sapiens	30-33
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	ATM serine/threonine kinase	Homo sapiens	94-97
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	ATR serine/threonine kinase	Homo sapiens	98-101
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Caffeine	68-76	growth arrest and DNA damage inducible alpha	Homo sapiens	168-174
14713027-11	2003	Caffeine and cotinine, a metabolite of nicotine, were generally present in STP effluents and surface waters contaminated by drugs.	Caffeine	0-8	thyroid hormone receptor interactor 10	Homo sapiens	75-78
15012901-11	2003	We suggest that although CYP2E1 is expressed in the tongue, it is rapidly degraded in this organ, and the nitrophenol hydroxylation and caffeine hydroxylation we observe is the result of activity of CYP1A1.	Caffeine	136-144	cytochrome P450 1A1	Oryctolagus cuniculus	199-205
14573390-0	2003	Caffeine reduces hypnotic effects of alcohol through adenosine A2A receptor blockade.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	53-75
14654375-7	2003	IL-2 inhibited the frequency relationship of caffeine-induced Ca(2+) release.	Caffeine	45-53	interleukin 2	Rattus norvegicus	0-4
14645677-8	2003	Collectively, these results demonstrate for the first time that caffeine alters D2R expression in neurons.	Caffeine	64-72	dopamine receptor D2	Mus musculus	80-83
14654375-3	2003	In the steady state (0.2 Hz) IL-2 (200 U/ml) decreased the amplitude of Ca(2+) transients induced by electrical stimulation and caffeine.	Caffeine	128-136	interleukin 2	Rattus norvegicus	29-33
14645677-0	2003	Caffeine regulates neuronal expression of the dopamine 2 receptor gene.	Caffeine	0-8	dopamine receptor D2	Mus musculus	46-65
14645677-2	2003	Here, we report that caffeine stimulates transcription of the dopamine 2 receptor (D2R) gene in PC-12 cells and primary striatal cultures and increases D2R protein expression in the striatum.	Caffeine	21-29	dopamine receptor D2	Mus musculus	62-81
14645677-2	2003	Here, we report that caffeine stimulates transcription of the dopamine 2 receptor (D2R) gene in PC-12 cells and primary striatal cultures and increases D2R protein expression in the striatum.	Caffeine	21-29	dopamine receptor D2	Mus musculus	83-86
14645677-2	2003	Here, we report that caffeine stimulates transcription of the dopamine 2 receptor (D2R) gene in PC-12 cells and primary striatal cultures and increases D2R protein expression in the striatum.	Caffeine	21-29	dopamine receptor D2	Mus musculus	152-155
14645677-3	2003	Physiological doses of caffeine and the specific adenosine 2A receptor antagonist 8-(3-chlorostyryl) caffeine both increased the activity of a D2R/luciferase reporter construct within 24 h, and simultaneous treatment with 2-[p-(2-carboxyethyl)phenethylamino]-5"-N-ethylcarboxamidoadenosine (CGS 21680), a specific adenosine 2A receptor agonist, eliminated this effect.	Caffeine	23-31	dopamine receptor D2	Mus musculus	143-146
14645677-4	2003	Tests of additional constructs revealed that specific regions of the D2R promoter (-117/-75) and 5"-untranslated region (+22/+317) were required for activation of D2R gene expression by caffeine.	Caffeine	186-194	dopamine receptor D2	Mus musculus	69-72
14645677-4	2003	Tests of additional constructs revealed that specific regions of the D2R promoter (-117/-75) and 5"-untranslated region (+22/+317) were required for activation of D2R gene expression by caffeine.	Caffeine	186-194	dopamine receptor D2	Mus musculus	163-166
14645677-5	2003	In primary striatal cultures, caffeine increased spontaneous firing of neurons between 12 and 80 min after treatment, whereas it increased D2R mRNA expression after only 4 h. These results indicate that regulation of D2R gene expression by caffeine occurs after the initial physiological response has subsided.	Caffeine	30-38	dopamine receptor D2	Mus musculus	139-142
14645677-5	2003	In primary striatal cultures, caffeine increased spontaneous firing of neurons between 12 and 80 min after treatment, whereas it increased D2R mRNA expression after only 4 h. These results indicate that regulation of D2R gene expression by caffeine occurs after the initial physiological response has subsided.	Caffeine	30-38	dopamine receptor D2	Mus musculus	217-220
14645677-5	2003	In primary striatal cultures, caffeine increased spontaneous firing of neurons between 12 and 80 min after treatment, whereas it increased D2R mRNA expression after only 4 h. These results indicate that regulation of D2R gene expression by caffeine occurs after the initial physiological response has subsided.	Caffeine	240-248	dopamine receptor D2	Mus musculus	139-142
14643431-4	2003	Incubation in caffeine did not increase the percentage of cells entering the S phase 6-8h after irradiation; ATM-dependent phosphorylation of p53 and transactivation of p21(Cip1/Waf1) post-IR were resistant to caffeine.	Caffeine	14-22	tumor protein p53	Homo sapiens	142-145
14645677-5	2003	In primary striatal cultures, caffeine increased spontaneous firing of neurons between 12 and 80 min after treatment, whereas it increased D2R mRNA expression after only 4 h. These results indicate that regulation of D2R gene expression by caffeine occurs after the initial physiological response has subsided.	Caffeine	240-248	dopamine receptor D2	Mus musculus	217-220
14645677-6	2003	In vivo, female mice treated with a dose of caffeine (50 mg/kg) showed 1.94- and 2.07-fold increases in D2R mRNA and protein expression, respectively.	Caffeine	44-52	dopamine receptor D2	Mus musculus	104-107
14643431-4	2003	Incubation in caffeine did not increase the percentage of cells entering the S phase 6-8h after irradiation; ATM-dependent phosphorylation of p53 and transactivation of p21(Cip1/Waf1) post-IR were resistant to caffeine.	Caffeine	14-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	169-172
14643431-4	2003	Incubation in caffeine did not increase the percentage of cells entering the S phase 6-8h after irradiation; ATM-dependent phosphorylation of p53 and transactivation of p21(Cip1/Waf1) post-IR were resistant to caffeine.	Caffeine	14-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	173-177
14643431-8	2003	This effect was reversed by expression of DNA polymerase eta, indicating that translesion synthesis of UVC-induced pyrimidine dimers by DNA pol eta protects human fibroblasts against UVC genotoxic effects even when other DNA repair functions are compromised by caffeine.	Caffeine	261-269	DNA polymerase eta	Homo sapiens	42-60
14605666-3	2003	Caffeine, a xanthine analogue, is well known to enhance the cytocidal and growth-inhibitory effects of DNA-damaging agents such as radiation, UV light, and anticancer agents on tumor cells by abrogating DNA-damage checkpoints through inhibition of ataxia-telangiectasia-mutated (ATM), and ATM and Rad3-related (ATR) kinase activity.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	248-277
14599774-3	2003	Pentoxifylline and the related drug Caffeine are known radiosensitizers especially in p53 mutant cells.	Caffeine	36-44	tumor protein p53	Homo sapiens	86-89
14599774-6	2003	The picture now emerging shows that Caffeine and Pentoxifylline inhibit homologous recombination by targeting members of the PIK kinase family (ATM and ATR) which facilitate repair in G2.	Caffeine	36-44	ATM serine/threonine kinase	Homo sapiens	144-147
14599774-6	2003	The picture now emerging shows that Caffeine and Pentoxifylline inhibit homologous recombination by targeting members of the PIK kinase family (ATM and ATR) which facilitate repair in G2.	Caffeine	36-44	ATR serine/threonine kinase	Homo sapiens	152-155
14605666-3	2003	Caffeine, a xanthine analogue, is well known to enhance the cytocidal and growth-inhibitory effects of DNA-damaging agents such as radiation, UV light, and anticancer agents on tumor cells by abrogating DNA-damage checkpoints through inhibition of ataxia-telangiectasia-mutated (ATM), and ATM and Rad3-related (ATR) kinase activity.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	279-282
14605666-3	2003	Caffeine, a xanthine analogue, is well known to enhance the cytocidal and growth-inhibitory effects of DNA-damaging agents such as radiation, UV light, and anticancer agents on tumor cells by abrogating DNA-damage checkpoints through inhibition of ataxia-telangiectasia-mutated (ATM), and ATM and Rad3-related (ATR) kinase activity.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	289-292
14730101-14	2003	Moreover, the observed reaction-dependent effects of promazine and sertindole provide indirect evidence that CYP1A2 is not the only isoenzyme important for the metabolism of caffeine, which requires further pharmacological and clinical consideration.	Caffeine	174-182	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	109-115
14713367-3	2003	Twenty-six healthy subjects were studied to evaluate their baseline activity of CYP1A2 and XO by the respective urinary metabolic ratios of an 8-h urine sample after an oral 150-mg dose of caffeine and of CYP3A by a urinary excretion ratio of 6beta-hydroxycortisol (6beta-HC) to free cortisol (FC).	Caffeine	189-197	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
14730100-2	2003	Caffeine undergoes 3-N-demethylation via CYP1A2, as well as 1-N-demethylation, 7-N-demethylation and 8-hydroxylation, which may involve other CYP isoenzymes.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	41-47
14730100-14	2003	The obtained results provide further indirect evidence that apart from CYP1A2, other CYP isoforms are also important for the metabolism of caffeine.	Caffeine	139-147	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	71-77
14550302-4	2003	The effect of ras2 mutation on the growth of yfh1 null strain was masked by the addition of caffeine.	Caffeine	92-100	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	14-18
14730101-1	2003	Caffeine is a marker drug for testing the activity of CYP1A2 (3-N-demethylation) in humans and rats.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	54-60
14730101-3	2003	In the case of 1-N- and, in particular, 7-N-demethylation of caffeine, apart from CYP1A2, other CYP isoenzymes play a considerable role, probably CYP2B and/or CYP2E1.	Caffeine	61-69	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	82-88
14730101-3	2003	In the case of 1-N- and, in particular, 7-N-demethylation of caffeine, apart from CYP1A2, other CYP isoenzymes play a considerable role, probably CYP2B and/or CYP2E1.	Caffeine	61-69	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	159-165
14730101-11	2003	In summary, among the investigated neuroleptics, only promazine showed significant inhibitory activity towards caffeine metabolism in vitro (inhibition of CYP1A2 and possibly CYP3A), which may be of pharmacological and clinical importance in vivo.	Caffeine	111-119	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	155-161
14730101-11	2003	In summary, among the investigated neuroleptics, only promazine showed significant inhibitory activity towards caffeine metabolism in vitro (inhibition of CYP1A2 and possibly CYP3A), which may be of pharmacological and clinical importance in vivo.	Caffeine	111-119	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	175-180
14550302-4	2003	The effect of ras2 mutation on the growth of yfh1 null strain was masked by the addition of caffeine.	Caffeine	92-100	ferroxidase	Saccharomyces cerevisiae S288C	45-49
12890678-5	2003	We found that H2O2 induced phosphorylation of the PDGF beta receptor and increased ATM kinase activity, two events integral to p53 activation as either AG1433 (a PDGF beta receptor inhibitor) or caffeine (an ATM kinase inhibitor) inhibited Ser-15 phosphorylation.	Caffeine	195-203	platelet derived growth factor subunit B	Homo sapiens	50-59
12897072-9	2003	These observations suggest that the increased binding of Drf1 to aphidicolin-treated chromatin is an active process that is mediated by a caffeine-sensitive checkpoint pathway containing ATR and Claspin.	Caffeine	138-146	DBF4 zinc finger B L homeolog	Xenopus laevis	57-61
12897072-9	2003	These observations suggest that the increased binding of Drf1 to aphidicolin-treated chromatin is an active process that is mediated by a caffeine-sensitive checkpoint pathway containing ATR and Claspin.	Caffeine	138-146	ATR serine/threonine kinase L homeolog	Xenopus laevis	187-190
12897072-9	2003	These observations suggest that the increased binding of Drf1 to aphidicolin-treated chromatin is an active process that is mediated by a caffeine-sensitive checkpoint pathway containing ATR and Claspin.	Caffeine	138-146	claspin S homeolog	Xenopus laevis	195-202
14641996-6	2003	In myotubes of individuals carrying the RyR1 Ile2182Phe or the RyR1 Gly2375Ala mutation, the EC(50) for caffeine and halothane was reduced; in the Ile2182Phe myotubes, the EC(50) for 4CmC was also reduced, all consistent with facilitated calcium release from the sarcoplasmic reticulum.	Caffeine	104-112	ryanodine receptor 1	Homo sapiens	40-44
14505449-14	2003	Notwithstanding, ryanodine can inhibit InsP(3)-mediated Ca(2+) responses after RyR activity has been induced by caffeine or by steady depolarization which evokes spontaneous transient outward currents (a sarcolemmal manifestation of RyR activity).	Caffeine	112-120	ryanodine receptor 2	Homo sapiens	79-82
14641996-6	2003	In myotubes of individuals carrying the RyR1 Ile2182Phe or the RyR1 Gly2375Ala mutation, the EC(50) for caffeine and halothane was reduced; in the Ile2182Phe myotubes, the EC(50) for 4CmC was also reduced, all consistent with facilitated calcium release from the sarcoplasmic reticulum.	Caffeine	104-112	ryanodine receptor 1	Homo sapiens	63-67
12847089-5	2003	ATM autophosphorylation in cells is also increased when caffeine is used in combination with inhibitors of replication suggesting that ATM activity is not inhibited in vivo by caffeine.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	135-138
12847089-6	2003	Furthermore, CHK1 hyperphosphorylation induced by caffeine in combination with hydroxyurea is ATR-dependent suggesting that ATR activity is stimulated by caffeine.	Caffeine	50-58	ATR serine/threonine kinase	Homo sapiens	94-97
12847089-2	2003	Caffeine has been widely used to study ATM and ATR signaling because it inhibits these kinases in vitro and overcomes cell cycle checkpoint responses in vivo.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	39-42
12847089-2	2003	Caffeine has been widely used to study ATM and ATR signaling because it inhibits these kinases in vitro and overcomes cell cycle checkpoint responses in vivo.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	47-50
12847089-6	2003	Furthermore, CHK1 hyperphosphorylation induced by caffeine in combination with hydroxyurea is ATR-dependent suggesting that ATR activity is stimulated by caffeine.	Caffeine	50-58	ATR serine/threonine kinase	Homo sapiens	124-127
12847089-3	2003	Thus, caffeine has been thought to overcome the checkpoint through its ability to prevent phosphorylation of ATM and ATR substrates.	Caffeine	6-14	ATM serine/threonine kinase	Homo sapiens	109-112
12847089-6	2003	Furthermore, CHK1 hyperphosphorylation induced by caffeine in combination with hydroxyurea is ATR-dependent suggesting that ATR activity is stimulated by caffeine.	Caffeine	154-162	ATR serine/threonine kinase	Homo sapiens	94-97
12847089-3	2003	Thus, caffeine has been thought to overcome the checkpoint through its ability to prevent phosphorylation of ATM and ATR substrates.	Caffeine	6-14	ATR serine/threonine kinase	Homo sapiens	117-120
12847089-4	2003	Surprisingly, I have found that multiple ATM-ATR substrates including CHK1 and -2 are hyperphosphorylated in cells treated with caffeine and genotoxic agents such as hydroxyurea or ionizing radiation.	Caffeine	128-136	ATM serine/threonine kinase	Homo sapiens	41-44
12847089-6	2003	Furthermore, CHK1 hyperphosphorylation induced by caffeine in combination with hydroxyurea is ATR-dependent suggesting that ATR activity is stimulated by caffeine.	Caffeine	154-162	ATR serine/threonine kinase	Homo sapiens	124-127
12847089-4	2003	Surprisingly, I have found that multiple ATM-ATR substrates including CHK1 and -2 are hyperphosphorylated in cells treated with caffeine and genotoxic agents such as hydroxyurea or ionizing radiation.	Caffeine	128-136	ATR serine/threonine kinase	Homo sapiens	45-48
12847089-8	2003	This data suggests that although caffeine is an inhibitor of ATM-ATR kinase activity in vitro, it can block checkpoints without inhibiting ATM-ATR activation in vivo.	Caffeine	33-41	ATM serine/threonine kinase	Homo sapiens	61-64
12847089-4	2003	Surprisingly, I have found that multiple ATM-ATR substrates including CHK1 and -2 are hyperphosphorylated in cells treated with caffeine and genotoxic agents such as hydroxyurea or ionizing radiation.	Caffeine	128-136	checkpoint kinase 1	Homo sapiens	70-81
12847089-5	2003	ATM autophosphorylation in cells is also increased when caffeine is used in combination with inhibitors of replication suggesting that ATM activity is not inhibited in vivo by caffeine.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	0-3
12847089-8	2003	This data suggests that although caffeine is an inhibitor of ATM-ATR kinase activity in vitro, it can block checkpoints without inhibiting ATM-ATR activation in vivo.	Caffeine	33-41	ATR serine/threonine kinase	Homo sapiens	65-68
12919186-1	2003	AIMS: To identify the molecular basis for a low CYP1A2 metabolic status, as determined by a caffeine phenotyping test, in a 71-year-old, nonsmoking, Caucasian woman who presented with very high clozapine concentrations despite being administered a standard dose of the drug.	Caffeine	92-100	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	48-54
12919952-6	2003	However, Ca2+ release was augmented in cells expressing mutant hRyR2 after RyR activation (caffeine and 4-chloro-m-cresol) or beta-adrenergic stimulation (isoproterenol).	Caffeine	91-99	ryanodine receptor 2	Homo sapiens	63-68
12919952-6	2003	However, Ca2+ release was augmented in cells expressing mutant hRyR2 after RyR activation (caffeine and 4-chloro-m-cresol) or beta-adrenergic stimulation (isoproterenol).	Caffeine	91-99	ryanodine receptor 2	Homo sapiens	64-67
12919952-7	2003	RyR2:FKBP12.6 interaction remained intact after caffeine or 4-CMC activation, but was dramatically disrupted by isoproterenol or forskolin, an activator of adenylate cyclase.	Caffeine	48-56	ryanodine receptor 2	Homo sapiens	0-4
12919952-7	2003	RyR2:FKBP12.6 interaction remained intact after caffeine or 4-CMC activation, but was dramatically disrupted by isoproterenol or forskolin, an activator of adenylate cyclase.	Caffeine	48-56	FKBP prolyl isomerase 1B	Homo sapiens	5-13
13679850-8	2003	Chk1 phosphorylation, decrease of Cdc25 A levels and S-phase arrest were abolished by caffeine, demonstrating that active checkpoint signaling rather than passive mechanical blockage by ICLs causes the PUVA-induced replication arrest.	Caffeine	86-94	checkpoint kinase 1	Homo sapiens	0-4
13679850-8	2003	Chk1 phosphorylation, decrease of Cdc25 A levels and S-phase arrest were abolished by caffeine, demonstrating that active checkpoint signaling rather than passive mechanical blockage by ICLs causes the PUVA-induced replication arrest.	Caffeine	86-94	cell division cycle 25A	Homo sapiens	34-41
12956959-4	2003	The accumulation of 53BP1 on uncapped telomeres was reduced in the presence of the PI3 kinase inhibitors caffeine and wortmannin, which affect ATM, ATR, and DNA-PK.	Caffeine	105-113	ATM serine/threonine kinase	Homo sapiens	143-146
12956959-4	2003	The accumulation of 53BP1 on uncapped telomeres was reduced in the presence of the PI3 kinase inhibitors caffeine and wortmannin, which affect ATM, ATR, and DNA-PK.	Caffeine	105-113	ATR serine/threonine kinase	Homo sapiens	148-151
12956959-4	2003	The accumulation of 53BP1 on uncapped telomeres was reduced in the presence of the PI3 kinase inhibitors caffeine and wortmannin, which affect ATM, ATR, and DNA-PK.	Caffeine	105-113	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	157-163
12956959-5	2003	By contrast, Mre11 TIFs were resistant to caffeine, consistent with previous findings on the Mre11 response to ionizing radiation.	Caffeine	42-50	MRE11 homolog, double strand break repair nuclease	Homo sapiens	13-18
12898220-7	2003	Five ketamine sensitive revertants recovered from the missense mutant unc-68(kh30) showed altered responses to caffeine, ryanodine, levamisole and ouabain relative to those of the unc-68(kh30) animals.	Caffeine	111-119	Uncharacterized protein	Caenorhabditis elegans	70-76
12893087-12	2003	U.S.A. 72 (1975): 219] in XP-V; (i) smaller replication products were accumulated after UV irradiation; (ii) the elongation of these products was delayed; (iii) the elongation was markedly inhibited by caffeine.	Caffeine	202-210	DNA polymerase eta	Homo sapiens	26-30
12902982-6	2003	Treatment with the ATM/ATR kinase inhibitor caffeine prevented p53 accumulation upon activation of Myc or E2F1.	Caffeine	44-52	ATM serine/threonine kinase	Homo sapiens	19-22
12902982-6	2003	Treatment with the ATM/ATR kinase inhibitor caffeine prevented p53 accumulation upon activation of Myc or E2F1.	Caffeine	44-52	tumor protein p53	Homo sapiens	63-66
12902982-6	2003	Treatment with the ATM/ATR kinase inhibitor caffeine prevented p53 accumulation upon activation of Myc or E2F1.	Caffeine	44-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	99-102
12902982-6	2003	Treatment with the ATM/ATR kinase inhibitor caffeine prevented p53 accumulation upon activation of Myc or E2F1.	Caffeine	44-52	E2F transcription factor 1	Homo sapiens	106-110
12909320-8	2003	The amplitude of caffeine-induced Ca(2+) transients was lower in cardiomyocytes from junctin-overexpressing mice.	Caffeine	17-25	aspartate-beta-hydroxylase	Mus musculus	85-92
12759219-8	2003	Incubation of muscles with 3 mM caffeine, which is also known to increase Ca2+ without affecting the cellular energy state, reduced HSL activity (24%, P &lt; 0.05).	Caffeine	32-40	lipase E, hormone sensitive type	Rattus norvegicus	132-135
12907610-0	2003	Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.	Caffeine	26-34	transformation related protein 53, pseudogene	Mus musculus	54-57
12907610-0	2003	Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.	Caffeine	26-34	BCL2-associated X protein	Mus musculus	59-62
12834577-1	2003	Caffeine is the most commonly consumed drug in the world, and athletes frequently use it as an ergogenic aid.	Caffeine	0-8	activation induced cytidine deaminase	Homo sapiens	105-108
12907610-0	2003	Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.	Caffeine	26-34	caspase 3	Mus musculus	68-77
12907610-6	2003	Induction of apoptosis by caffeine appeared to be p53-dependent because cells lacking p53 (p53(-/-)) showed no signs of apoptosis after treatment with caffeine.	Caffeine	26-34	transformation related protein 53, pseudogene	Mus musculus	50-53
12907610-7	2003	Immunoprecipitation assays and Western blot analysis showed that caffeine induced phosphorylation of p53 at Ser(15) in JB6 Cl41 cells.	Caffeine	65-73	transformation related protein 53, pseudogene	Mus musculus	101-104
12907610-8	2003	The same low concentration of caffeine that was effective for inducing phosphorylation of p53 was also shown to increase p53 activation.	Caffeine	30-38	transformation related protein 53, pseudogene	Mus musculus	90-93
12907610-8	2003	The same low concentration of caffeine that was effective for inducing phosphorylation of p53 was also shown to increase p53 activation.	Caffeine	30-38	transformation related protein 53, pseudogene	Mus musculus	121-124
12907610-11	2003	These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways.	Caffeine	44-52	tumor protein p53	Homo sapiens	64-67
12907610-11	2003	These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways.	Caffeine	44-52	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
12907610-11	2003	These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways.	Caffeine	44-52	caspase 3	Homo sapiens	121-130
12900870-2	2003	Mephenytoin (MEPH), dextromethorphan, diclofenac, caffeine, and methadone (MET) were successfully applied as test substrates for CYP2C19, CYP2D6*1, CYP2C9*1, CYP1A2, and CYP3A4, respectively.	Caffeine	50-58	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	129-136
12900870-2	2003	Mephenytoin (MEPH), dextromethorphan, diclofenac, caffeine, and methadone (MET) were successfully applied as test substrates for CYP2C19, CYP2D6*1, CYP2C9*1, CYP1A2, and CYP3A4, respectively.	Caffeine	50-58	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	138-144
12811820-0	2003	Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells.	Caffeine	0-8	tumor protein p53	Homo sapiens	55-58
12874107-7	2003	The resting [Ca(2+)](i) is 17.1% lower in Pkd2 (+/-) compared with wild-type cells (P=0.0003) and the total sarcoplasmic reticulum Ca(2+) store (emptied by caffeine plus thapsigargin) is decreased (P&lt;0.0001).	Caffeine	156-164	polycystin 2, transient receptor potential cation channel	Mus musculus	42-46
12811820-1	2003	Methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser-15 residue.	Caffeine	26-34	tumor protein p53	Homo sapiens	60-63
12811820-1	2003	Methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser-15 residue.	Caffeine	26-34	tumor protein p53	Homo sapiens	170-173
12811820-2	2003	In contrast, it has been reported that caffeine induces p53-mediated apoptosis through Bax protein in non-small-cell lung cancer cells.	Caffeine	39-47	tumor protein p53	Homo sapiens	56-59
12811820-2	2003	In contrast, it has been reported that caffeine induces p53-mediated apoptosis through Bax protein in non-small-cell lung cancer cells.	Caffeine	39-47	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
12811820-6	2003	Caffeine induced G(2)/M phase cell cycle arrest in NB4 cells in association with the induction of phosphorylation at the Ser-15 residue of p53 and induction of tyrosine phosphorylation of cdc2.	Caffeine	0-8	tumor protein p53	Homo sapiens	139-142
12811820-6	2003	Caffeine induced G(2)/M phase cell cycle arrest in NB4 cells in association with the induction of phosphorylation at the Ser-15 residue of p53 and induction of tyrosine phosphorylation of cdc2.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	188-192
12811820-7	2003	Expression of Bax protein was increased in NB4 cells after treatment with caffeine.	Caffeine	74-82	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
12811820-8	2003	Interestingly, the antisense oligonucleotides for p53 significantly reduced p53 expression and caffeine-induced G(2)/M phase cell cycle arrest in NB4 cells.	Caffeine	95-103	tumor protein p53	Homo sapiens	50-53
12811820-9	2003	These results suggest that caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53.	Caffeine	27-35	tumor protein p53	Homo sapiens	110-113
12811820-9	2003	These results suggest that caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53.	Caffeine	27-35	cyclin dependent kinase 1	Homo sapiens	205-210
12811820-9	2003	These results suggest that caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53.	Caffeine	27-35	tumor protein p53	Homo sapiens	241-244
12938061-13	2003	The author advocates the use of a dietetic treatment in association with the intake of small amounts of caffeine BID.	Caffeine	104-112	BH3 interacting domain death agonist	Homo sapiens	113-116
12794177-8	2003	Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity.	Caffeine	87-95	lipase E, hormone sensitive type	Rattus norvegicus	173-176
12834266-3	2003	This study verified the effect of caffeine on NTPDase 1 (ATP diphosphohydrolase) and 5"-nucleotidase of synaptosomes from hippocampus and striatum of rats.	Caffeine	34-42	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	46-55
12730349-2	2003	IL-2 (200 U/ml) decreased the amplitude of electrically stimulated and caffeine-induced intracellular Ca2+ transients in ventricular myocytes, but increased the end-diastolic calcium level.	Caffeine	71-79	interleukin 2	Rattus norvegicus	0-4
12805242-7	2003	Caffeine-induced Ca2+ release from the sarcoplasmic reticulum (SR) and the accompanying inward Na+-Ca2+ exchanger (NCX) current revealed a significantly lower SR Ca2+ content and faster Ca2+-extrusion kinetics in Ad-sorcin-transfected cells.	Caffeine	0-8	sorcin	Oryctolagus cuniculus	216-222
12709444-6	2003	Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p &lt; 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells.	Caffeine	373-381	LOW QUALITY PROTEIN: ryanodine receptor 1	Cricetulus griseus	76-80
12721284-4	2003	S100A1 equally enhanced caffeine-induced SR Ca2+ release and Ca2+-induced isometric force transients in both muscle preparations in a dose-dependent manner.	Caffeine	24-32	S100 calcium binding protein A1	Mus musculus	0-6
12874009-3	2003	In HT1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused G(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (ATM) and atm and rad3-related (ATR).	Caffeine	173-181	tumor protein p53	Homo sapiens	55-58
12874009-3	2003	In HT1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused G(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (ATM) and atm and rad3-related (ATR).	Caffeine	173-181	ATM serine/threonine kinase	Homo sapiens	228-257
12874009-3	2003	In HT1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused G(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (ATM) and atm and rad3-related (ATR).	Caffeine	173-181	ATM serine/threonine kinase	Homo sapiens	259-262
12874009-3	2003	In HT1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused G(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (ATM) and atm and rad3-related (ATR).	Caffeine	173-181	ATM serine/threonine kinase	Homo sapiens	63-66
12874009-3	2003	In HT1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused G(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (ATM) and atm and rad3-related (ATR).	Caffeine	173-181	ATR serine/threonine kinase	Homo sapiens	290-293
12709444-6	2003	Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p &lt; 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells.	Caffeine	373-381	A kinase (PRKA) anchor protein 1	Mus musculus	126-131
12807744-3	2003	Interestingly, the methylxanthine caffeine can abrogate the p53 accumulation induced by certain DNA-damaging agents by an unknown mechanism.	Caffeine	34-42	tumor protein p53	Homo sapiens	60-63
12620813-6	2003	Ca2+ sparks and transients evoked by norepinephrine and caffeine were abolished by thimerosal (100 microM), which sensitizes the IP3R to IP3.	Caffeine	56-64	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	0-3
12807744-5	2003	Caffeine inhibited the accumulation of p53 induced by leptomycin B (LMB), an inhibitor of CRM1, but not N-acetyl-leu-leu-norleucinal, a proteasome inhibitor.	Caffeine	0-8	tumor protein p53	Homo sapiens	39-42
12807744-5	2003	Caffeine inhibited the accumulation of p53 induced by leptomycin B (LMB), an inhibitor of CRM1, but not N-acetyl-leu-leu-norleucinal, a proteasome inhibitor.	Caffeine	0-8	exportin 1	Homo sapiens	90-94
12807744-6	2003	Furthermore, caffeine also inhibited the accumulation of p53 by a variety of stress-inducing agents in vivo, such as 5-fluorouracil, doxorubicin, mitomycin C, camptothecin and roscovitine.	Caffeine	13-21	tumor protein p53	Homo sapiens	57-60
12700682-9	2003	Chronic exposure to caffeine in the drinking water (1.0 mg/ml) resulted in tolerance to the motor effects of an acute administration of caffeine, lack of tolerance to amphetamine, apparent tolerance to MSX-3 (shift to the left of its "bell-shaped" dose-response curve), and true cross-tolerance to CPT.	Caffeine	20-28	msh homeobox 3	Rattus norvegicus	202-207
12835721-6	2003	(3) 1.5 mM caffeine that relieves cells from G(2)/M arrest also inhibits As(2)O(3)-induced Deltavarphi(m) collapse and apoptosis, (4) 1.0 micro M As(2)O(3) increases the expression of both cyclin B(1) and hCDC20 whereas it inhibits Tyr15 phosphorylation of p34(cdc2).	Caffeine	11-19	cyclin B1	Homo sapiens	189-200
12835721-6	2003	(3) 1.5 mM caffeine that relieves cells from G(2)/M arrest also inhibits As(2)O(3)-induced Deltavarphi(m) collapse and apoptosis, (4) 1.0 micro M As(2)O(3) increases the expression of both cyclin B(1) and hCDC20 whereas it inhibits Tyr15 phosphorylation of p34(cdc2).	Caffeine	11-19	cell division cycle 20	Homo sapiens	205-211
12835721-6	2003	(3) 1.5 mM caffeine that relieves cells from G(2)/M arrest also inhibits As(2)O(3)-induced Deltavarphi(m) collapse and apoptosis, (4) 1.0 micro M As(2)O(3) increases the expression of both cyclin B(1) and hCDC20 whereas it inhibits Tyr15 phosphorylation of p34(cdc2).	Caffeine	11-19	alpha and gamma adaptin binding protein	Homo sapiens	257-260
12835721-6	2003	(3) 1.5 mM caffeine that relieves cells from G(2)/M arrest also inhibits As(2)O(3)-induced Deltavarphi(m) collapse and apoptosis, (4) 1.0 micro M As(2)O(3) increases the expression of both cyclin B(1) and hCDC20 whereas it inhibits Tyr15 phosphorylation of p34(cdc2).	Caffeine	11-19	cyclin dependent kinase 1	Homo sapiens	261-265
12828922-0	2003	Caffeine enhances the expression of the angiotensin II Type 2 receptor mRNA in BeWo cell culture and in the rat placenta.	Caffeine	0-8	angiotensin II receptor type 2	Homo sapiens	40-70
12921667-10	2003	(3)The increase of Ca(2+) concentration induced by caffeine or ryanodine suggested the involvement of both the cyclic adenosine diphosphate ribose and the inositol 1,4,5-triphosphate systems in the regulation of intracellular calcium in LEC-B3, and IP(3R) is more sensitive to free Ca(2+) modulation than RyR.	Caffeine	51-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	249-254
12921667-10	2003	(3)The increase of Ca(2+) concentration induced by caffeine or ryanodine suggested the involvement of both the cyclic adenosine diphosphate ribose and the inositol 1,4,5-triphosphate systems in the regulation of intracellular calcium in LEC-B3, and IP(3R) is more sensitive to free Ca(2+) modulation than RyR.	Caffeine	51-59	ryanodine receptor 1	Homo sapiens	305-308
12704193-3	2003	Wild-type RyR1-, V246I-, and V2461G-expressing myotubes exhibited similar resting Ca2+ levels and maximal responses to caffeine (10 mm) and cyclopiazonic acid (30 microm).	Caffeine	119-127	ryanodine receptor 1, skeletal muscle	Mus musculus	10-14
12803575-0	2003	Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio.	Caffeine	82-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
12742114-1	2003	Caffeine is metabolised in humans primarily by cytochromes P450 1A2 and 2A6, xanthine dehydrogenase/oxidase, and N-acetyltransferase 2.	Caffeine	0-8	xanthine dehydrogenase	Homo sapiens	77-134
12676925-4	2003	The degradation of Cdc25A is abrogated by caffeine, which implicates Chk1 as the potential mediator (Mailand, N., Falck, J., Lukas, C., Syljuasen, R. G., Welcker, M., Bartek, J., and Lukas, J.	Caffeine	42-50	cell division cycle 25A	Homo sapiens	19-25
12676925-4	2003	The degradation of Cdc25A is abrogated by caffeine, which implicates Chk1 as the potential mediator (Mailand, N., Falck, J., Lukas, C., Syljuasen, R. G., Welcker, M., Bartek, J., and Lukas, J.	Caffeine	42-50	checkpoint kinase 1	Homo sapiens	69-73
12676925-6	2003	However, the involvement of Chk1 is far from clear, because caffeine is a rather nonspecific inhibitor of the ATR/Chk1 signaling pathway.	Caffeine	60-68	ATR serine/threonine kinase	Homo sapiens	110-113
12676925-6	2003	However, the involvement of Chk1 is far from clear, because caffeine is a rather nonspecific inhibitor of the ATR/Chk1 signaling pathway.	Caffeine	60-68	checkpoint kinase 1	Homo sapiens	114-118
12738191-4	2003	The 0.3, 0.5, 1 and 2 g/kg treatments increased rat liver microsomal CYP1A2 activity measures as the conversion of caffeine to paraxanthine to 166, 212, 331 and 473% of normal, respectively.	Caffeine	115-123	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	69-75
12738191-5	2003	In humans, the intake of 2 and 4 capsules of the supplement for 3 days increased CYP1A2 activity to 194 and 203%, respectively, as assessed by the change in the urinary ratio of 1,7-dimethylxanthine plus paraxanthine to unmetabolized caffeine.	Caffeine	234-242	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-87
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	13-42
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	44-47
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	84-87
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	128-131
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-136
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-141
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	181-184
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-189
12767922-4	2003	Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression.	Caffeine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	190-194
12782595-4	2003	Furthermore, because caffeine and wortmannin attenuate p21(WAF1) induction in WT cells, it is probable that the phosphatidylinositol 3"-kinase activity is essential for this process.	Caffeine	21-29	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-58
12782595-4	2003	Furthermore, because caffeine and wortmannin attenuate p21(WAF1) induction in WT cells, it is probable that the phosphatidylinositol 3"-kinase activity is essential for this process.	Caffeine	21-29	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-63
12803575-2	2003	Provocation with caffeine is used to estimate CYP1A2 activity, but in most tests a long period of caffeine abstinence has to be taken into account.	Caffeine	17-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-52
12803578-11	2003	Note: All caffeine-related statements within the reviewed literature have been collected in tables (referred to as Table SX) which are provided in full text for check on the following website: http://www.blackwellpublishing.com/products/journals/suppmat/FCP/FCP174/FCP174sm.htm	Caffeine	10-18	FCP1	Homo sapiens	254-257
12930004-5	2003	The purpose of this study was to compare CYP1A2 activity in female subjects that were automobile exhaust exposed and non-automobile exhaust exposed using serum paraxanthine/caffeine ratio as an index.	Caffeine	173-181	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
12783948-0	2003	Caffeine-mediated presynaptic long-term potentiation in hippocampal CA1 pyramidal neurons.	Caffeine	0-8	carbonic anhydrase 1	Rattus norvegicus	68-71
12783948-5	2003	Inhibition of Ca2+ release from caffeine/ryanodine stores by bath-applied ryanodine inhibited the CAFLTP, but ryanodine in the pipette solution was ineffective, suggesting a presynaptic effect of ryanodine.	Caffeine	32-40	carbonic anhydrase 2	Rattus norvegicus	14-17
12795773-4	2003	At present, caffeine and chlorzoxazone are used most often as probe drugs for CYP1A2 and CYP2E1, respectively, but these are not necessarily the best probe drugs.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
12795773-4	2003	At present, caffeine and chlorzoxazone are used most often as probe drugs for CYP1A2 and CYP2E1, respectively, but these are not necessarily the best probe drugs.	Caffeine	12-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95
12930004-0	2003	Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects.	Caffeine	13-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	45-51
12930004-4	2003	Caffeine is primarily metabolized by CYP1A2 to paraxanthine, so it has been used as a specific probe for assessing CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
12930004-4	2003	Caffeine is primarily metabolized by CYP1A2 to paraxanthine, so it has been used as a specific probe for assessing CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	115-121
12930004-12	2003	CONCLUSION: Paraxanthine/caffeine ratio, as an index for CYP1A2 activity, can be used to determine PAHs exposure.	Caffeine	25-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
12881862-11	2003	Pretreatment with FAC attenuated the increased caffeine-releasable pool of Ca(2+) by IL-2.	Caffeine	47-55	interleukin 2	Homo sapiens	85-89
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	37-40
12706856-5	2003	CYP1A2 mRNA expression in the livers of the PhIP+caffeine group tended to be higher than in either the PhIP or the caffeine alone groups.	Caffeine	49-57	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
12706856-5	2003	CYP1A2 mRNA expression in the livers of the PhIP+caffeine group tended to be higher than in either the PhIP or the caffeine alone groups.	Caffeine	115-123	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
12894503-4	2003	The observed alteration of several potential ATR downstream targets suggests that inhibition of ATR activity may be one of the mechanism by which caffeine regulates sensitivity to cisplatin.	Caffeine	146-154	ATR serine/threonine kinase	Homo sapiens	45-48
12894503-4	2003	The observed alteration of several potential ATR downstream targets suggests that inhibition of ATR activity may be one of the mechanism by which caffeine regulates sensitivity to cisplatin.	Caffeine	146-154	ATR serine/threonine kinase	Homo sapiens	96-99
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	tumor protein p53	Homo sapiens	109-112
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	166-170
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	alpha and gamma adaptin binding protein	Homo sapiens	171-174
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin B1	Homo sapiens	175-184
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin B1	Homo sapiens	212-221
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	247-251
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	alpha and gamma adaptin binding protein	Homo sapiens	252-255
12714815-5	2003	RESULTS: Caffeine treatment showed glutathione depletion and increased lipid peroxidation with higher glutathione S-transferase activity in both B16F10 and B16F1 cell lines.	Caffeine	9-17	hematopoietic prostaglandin D synthase	Mus musculus	102-127
12694532-2	2003	RESULTS: Caffeine inhibited the Ran-GEF activity of RCC1 by preventing the binary complex formation of Ran-RCC1.	Caffeine	9-17	regulator of chromosome condensation	Mesocricetus auratus	107-111
12694532-3	2003	Inhibition of the Ran-GEF activity of RCC1 by caffeine and its derivatives was correlated with their ability to induce PCC.	Caffeine	46-54	GTP-binding nuclear protein Ran	Mesocricetus auratus	18-21
12694532-0	2003	Caffeine mimics adenine and 2"-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.	Caffeine	0-8	regulator of chromosome condensation	Mesocricetus auratus	113-117
12694532-3	2003	Inhibition of the Ran-GEF activity of RCC1 by caffeine and its derivatives was correlated with their ability to induce PCC.	Caffeine	46-54	regulator of chromosome condensation	Mesocricetus auratus	38-42
12694532-0	2003	Caffeine mimics adenine and 2"-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.	Caffeine	0-8	serine/threonine-protein kinase ATR	Mesocricetus auratus	145-148
12694532-4	2003	Since caffeine is a derivative of xanthine, the bases and nucleosides were screened for their ability to inhibit RCC1.	Caffeine	6-14	regulator of chromosome condensation	Mesocricetus auratus	113-117
12694532-1	2003	BACKGROUND: Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature chromatin condensation (PCC) in hamster BHK21 cells arrested in the S-phase, suggesting that RCC1 is a target for caffeine.	Caffeine	17-25	GTP-binding nuclear protein Ran	Mesocricetus auratus	104-107
12694532-7	2003	We found that both adenine and 2"-dA, but none of the other 2"-deoxynucleosides, inhibited the kinase activity of ATR, similar to that of caffeine.	Caffeine	138-146	serine/threonine-protein kinase ATR	Mesocricetus auratus	114-117
12694532-1	2003	BACKGROUND: Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature chromatin condensation (PCC) in hamster BHK21 cells arrested in the S-phase, suggesting that RCC1 is a target for caffeine.	Caffeine	17-25	regulator of chromosome condensation	Mesocricetus auratus	219-223
12694532-1	2003	BACKGROUND: Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature chromatin condensation (PCC) in hamster BHK21 cells arrested in the S-phase, suggesting that RCC1 is a target for caffeine.	Caffeine	240-248	regulator of chromosome condensation	Mesocricetus auratus	50-54
12694532-9	2003	CONCLUSION: The effect of caffeine on cell-cycle control mimics the biological effect of adenine and 2"-dA, both of which inhibit ATR.	Caffeine	26-34	serine/threonine-protein kinase ATR	Mesocricetus auratus	130-133
12694532-1	2003	BACKGROUND: Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature chromatin condensation (PCC) in hamster BHK21 cells arrested in the S-phase, suggesting that RCC1 is a target for caffeine.	Caffeine	240-248	GTP-binding nuclear protein Ran	Mesocricetus auratus	104-107
12694532-2	2003	RESULTS: Caffeine inhibited the Ran-GEF activity of RCC1 by preventing the binary complex formation of Ran-RCC1.	Caffeine	9-17	GTP-binding nuclear protein Ran	Mesocricetus auratus	32-35
12699383-4	2003	Autodock was used to dock chlorzoxazone, p-nitrophenol, N-nitrosodimethylamine, acetominophen, caffeine, theophylline, and methoxyflurane into the model CYP2E1 employing a model oxyferryl heme with charges based on density functional theoretical parametrization.	Caffeine	95-103	cytochrome P450 2E1	Oryctolagus cuniculus	153-159
12694532-2	2003	RESULTS: Caffeine inhibited the Ran-GEF activity of RCC1 by preventing the binary complex formation of Ran-RCC1.	Caffeine	9-17	regulator of chromosome condensation	Mesocricetus auratus	52-56
12694532-2	2003	RESULTS: Caffeine inhibited the Ran-GEF activity of RCC1 by preventing the binary complex formation of Ran-RCC1.	Caffeine	9-17	GTP-binding nuclear protein Ran	Mesocricetus auratus	103-106
12906366-0	2003	Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	104-127
12906366-1	2003	Caffeine is metabolized in the liver by cytochrome P450(CYP)1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-63
12906366-13	2003	These findings imply that caffeine, ingested in the evening at a dose corresponding to two ordinary cups of coffee, augments the nocturnal serum MT level, which in turn supports the notion that cytochrome P450(CYP)1A2 is involved in the hepatic metabolism of human MT.	Caffeine	26-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	194-217
12644842-0	2003	Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers.	Caffeine	56-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-40
12644842-2	2003	Caffeine has been shown to provide an accurate phenotypic probe for measuring CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
12679521-1	2003	Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	89-123
12576471-6	2003	These analyses revealed that RyR2(T1874-GFP) functions as a caffeine- and ryanodine-sensitive Ca(2+) release channel and displays Ca(2+) dependence and [(3)H]ryanodine binding properties similar to those of the wild type RyR2.	Caffeine	60-68	ryanodine receptor 2	Homo sapiens	29-33
12679521-1	2003	Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	129-132
12679521-1	2003	Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	89-92
12679521-6	2003	In contrast, retroviral transduction is not impeded in ATM-deficient cells, and addition of caffeine leads to the same reduction that was observed in ATM-proficient cells.	Caffeine	92-100	ATM serine/threonine kinase	Homo sapiens	150-153
12609973-6	2003	Moreover, CaM(1-4) elevated diastolic Ca2+ and caffeine-labile Ca2+ content of the SR. Inhibition of CaMKII by KN-93 or a myristoylated autocamtide-2 related inhibitory peptide prevented the aforementioned PLB phosphorylation and reversed the positive inotropic and relaxant effects, indicating that CaMKII is essential to CaM(1-4) actions.	Caffeine	47-55	calmodulin 1	Rattus norvegicus	10-13
12719724-6	2003	An ATR-kinase dead mutant or caffeine, which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.	Caffeine	29-37	ATR serine/threonine kinase	Homo sapiens	75-78
12646262-4	2003	Administration of caffeine to G2-arrested cells induced a drastic change in cell phenotype, the nature of which depended on the status of p53.	Caffeine	18-26	tumor protein p53	Homo sapiens	138-141
12646262-5	2003	Flow cytometric and microscopic observations revealed that cells that either contained or lacked p53 resumed their cell cycles and entered mitosis upon caffeine treatment.	Caffeine	152-160	tumor protein p53	Homo sapiens	97-100
12719724-6	2003	An ATR-kinase dead mutant or caffeine, which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.	Caffeine	29-37	tumor protein p53	Homo sapiens	129-132
12719724-6	2003	An ATR-kinase dead mutant or caffeine, which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.	Caffeine	29-37	tumor protein p53	Homo sapiens	187-190
12660173-5	2003	Chk1 phosphorylates Tlk1 on serine 695 (S695) in vitro, and this UCN-01- and caffeine-sensitive site is phosphorylated in vivo in response to DNA damage.	Caffeine	77-85	checkpoint kinase 1	Homo sapiens	0-4
12660173-5	2003	Chk1 phosphorylates Tlk1 on serine 695 (S695) in vitro, and this UCN-01- and caffeine-sensitive site is phosphorylated in vivo in response to DNA damage.	Caffeine	77-85	tousled like kinase 1	Homo sapiens	20-24
12665481-6	2003	Raising cytosolic Ca2+ by exposing L6 myotubes to caffeine for 5 h induced significant increases in PGC-1 and mtTFA protein expression and in NRF-1 and NRF-2 binding to DNA.	Caffeine	50-58	PPARG coactivator 1 alpha	Homo sapiens	100-105
12681001-7	2003	RESULTS: Caffeine treatment induced a marked, almost total neuroprotection in CA1 and a very limited protection in the hilus of the dentate gyrus, whereas damage in layers III-IV of the piriform cortex was slightly worsened by the treatment.	Caffeine	9-17	carbonic anhydrase 1	Rattus norvegicus	78-81
12665481-6	2003	Raising cytosolic Ca2+ by exposing L6 myotubes to caffeine for 5 h induced significant increases in PGC-1 and mtTFA protein expression and in NRF-1 and NRF-2 binding to DNA.	Caffeine	50-58	transcription factor A, mitochondrial	Homo sapiens	110-115
12665481-6	2003	Raising cytosolic Ca2+ by exposing L6 myotubes to caffeine for 5 h induced significant increases in PGC-1 and mtTFA protein expression and in NRF-1 and NRF-2 binding to DNA.	Caffeine	50-58	nuclear respiratory factor 1	Homo sapiens	142-147
12665481-6	2003	Raising cytosolic Ca2+ by exposing L6 myotubes to caffeine for 5 h induced significant increases in PGC-1 and mtTFA protein expression and in NRF-1 and NRF-2 binding to DNA.	Caffeine	50-58	NFE2 like bZIP transcription factor 2	Homo sapiens	152-157
12471029-5	2003	Although the RyR3 (AS-8a) splice variant did not form a functional Ca(2+) release channel when expressed alone in HEK293 cells, it was able to form functional heteromeric channels with reduced caffeine sensitivity when co-expressed with the wild type RyR3.	Caffeine	193-201	ryanodine receptor 3	Homo sapiens	13-17
15255635-4	2003	But pretreatment of caffeine for 12 consecutive days and continuation of its treatment during the course of development of EAC cells restored the EAC cell-induced changes in liver CAT, SOD and LP to their corresponding control values.	Caffeine	20-28	catalase	Mus musculus	180-183
12640212-6	2003	The mean urinary caffeine indexes of nonsmokers and smokers were 17 +/- 8 and 101 +/- 44, respectively, indicating that smoking had induced a sixfold higher CYP1A2 activity (p &lt;0.0001).	Caffeine	17-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	157-163
12662305-9	2003	Furthermore, AtPUP1 mediates transport of caffeine and ribosylated purine derivatives in yeast.	Caffeine	42-50	purine permease 1	Arabidopsis thaliana	13-19
12645530-9	2003	Caffeine inhibited ATM kinase activity for substrates but did not interfere with ATM autophosphorylation.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	19-22
12584315-6	2003	Furthermore, treatment with caffeine, a G(2) checkpoint inhibitor, abrogated the B19 virus-induced G(2) arrest despite expression of NS1.	Caffeine	28-36	influenza virus NS1A binding protein	Homo sapiens	133-136
12554775-3	2003	In dispersed rat anterior pituitary cells, depletion of intracellular Ca2+ stores with thapsigargin combined with ryanodine or caffeine enhanced the corticotropin releasing-factor (CRF)-evoked cAMP response by 4-fold, whereas reduction of Ca2+ entry alone had no effect.	Caffeine	127-135	corticotropin releasing hormone	Rattus norvegicus	149-179
12633866-3	2003	In the presence of 20 mM caffeine, only high concentrations of CCK, but not bombesin or JMV-180, suppressed the caffeine-resistant CCK or bombesin-induced [Ca(2+)]c oscillations, indicating that low affinity CCK receptors inhibit agonist-induced [Ca(2+)]c oscillations.	Caffeine	25-33	cholecystokinin	Homo sapiens	63-66
12646505-8	2003	Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72
12646505-8	2003	Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered.	Caffeine	147-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72
12600245-1	2003	Caffeine inhibits ATM and ATR, two important checkpoint regulators, abolishes ionizing radiation-induced checkpoint response, and radiosensitizes cells.	Caffeine	0-8	ATM serine/threonine kinase	Gallus gallus	18-21
12600245-1	2003	Caffeine inhibits ATM and ATR, two important checkpoint regulators, abolishes ionizing radiation-induced checkpoint response, and radiosensitizes cells.	Caffeine	0-8	ATR serine/threonine kinase	Gallus gallus	26-29
12600245-5	2003	We show that caffeine efficiently abolishes S- and G(2)-phase checkpoint responses after irradiation in all cell lines tested and greatly radiosensitizes wild-type and ATM(-/-) cells, the partially checkpoint-deficient cells.	Caffeine	13-21	ATM serine/threonine kinase	Gallus gallus	168-171
12600246-4	2003	Caffeine, as a nonspecific inhibitor of ATM and ATR, abolishes multi-checkpoint responses and sensitizes cells to radiation-induced killing.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	40-43
12600246-4	2003	Caffeine, as a nonspecific inhibitor of ATM and ATR, abolishes multi-checkpoint responses and sensitizes cells to radiation-induced killing.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	48-51
12557259-7	2003	In exocrine pancreatic cancer, caffeine, other coffee compounds, or other factors with which coffee drinking is associated could modulate Ki-ras activation by interfering with DNA repair, cell-cycle checkpoints, and apoptosis.	Caffeine	31-39	KRAS proto-oncogene, GTPase	Homo sapiens	138-144
12939992-3	2003	The adsorption amount of caffine is 2.65 mg.g-1 with 7.5% adsorption ratio when 100 mL of 0.71 g.L-1 caffine is adsorbed on polyamide resine, but the adsorption amount of tea polyphenol is up to 148.13 mg.g-1 with 85% adsorption ratio when 700 mL of 1.98 g.L-1 tea polyphenol is adsorbed on polyamide resine.	Caffeine	25-32	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
12939992-3	2003	The adsorption amount of caffine is 2.65 mg.g-1 with 7.5% adsorption ratio when 100 mL of 0.71 g.L-1 caffine is adsorbed on polyamide resine, but the adsorption amount of tea polyphenol is up to 148.13 mg.g-1 with 85% adsorption ratio when 700 mL of 1.98 g.L-1 tea polyphenol is adsorbed on polyamide resine.	Caffeine	25-32	immunoglobulin kappa variable 1-16	Homo sapiens	257-260
12939992-3	2003	The adsorption amount of caffine is 2.65 mg.g-1 with 7.5% adsorption ratio when 100 mL of 0.71 g.L-1 caffine is adsorbed on polyamide resine, but the adsorption amount of tea polyphenol is up to 148.13 mg.g-1 with 85% adsorption ratio when 700 mL of 1.98 g.L-1 tea polyphenol is adsorbed on polyamide resine.	Caffeine	101-108	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
12494452-8	2003	Moreover, EGF-induced Ca(2+) transients were abolished by the InsP(3) receptor blocker caffeine, while ryanodine was without effect.	Caffeine	87-95	epidermal growth factor like 1	Rattus norvegicus	10-13
12538862-7	2003	Caffeine administration induced c-Fos expression in the cortex of dopamine-deficient mice but had no effect in the striatum by itself.	Caffeine	0-8	FBJ osteosarcoma oncogene	Mus musculus	32-37
12538862-8	2003	Caffeine attenuated dopamine agonist-induced striatal c-Fos expression.	Caffeine	0-8	FBJ osteosarcoma oncogene	Mus musculus	54-59
12580991-6	2003	The caffeine metabolites acetyl-6-formylamino-3-methyluracil (AFMU), 1-methylxanthine (1MX), 1-methyluric acid (1MU), and 1,7-dimethyluric acid (17MU) were quantified by HPLC, and the corresponding metabolic ratios for CYP1A2, NAT2, and XO were then calculated.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	219-225
12580991-6	2003	The caffeine metabolites acetyl-6-formylamino-3-methyluracil (AFMU), 1-methylxanthine (1MX), 1-methyluric acid (1MU), and 1,7-dimethyluric acid (17MU) were quantified by HPLC, and the corresponding metabolic ratios for CYP1A2, NAT2, and XO were then calculated.	Caffeine	4-12	N-acetyltransferase 2	Homo sapiens	227-231
12429744-7	2003	The effect of PACAP-38 was also abolished by emptying the caffeine/ryanodine-sensitive Ca(2+) stores.	Caffeine	58-66	adenylate cyclase activating polypeptide 1	Homo sapiens	14-19
12701820-11	2003	The results of our study show that arginase and diamine oxidase were decreased in animals treated with caffeine.	Caffeine	103-111	amine oxidase, copper containing 1	Rattus norvegicus	48-63
12551740-2	2003	Smoking induces cytochrome P450 1A2 (CYP1A2), which is the main enzyme involved in caffeine metabolism.	Caffeine	83-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-35
12551740-2	2003	Smoking induces cytochrome P450 1A2 (CYP1A2), which is the main enzyme involved in caffeine metabolism.	Caffeine	83-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
12538785-6	2003	In addition, the hypoxic respiratory depression is clearly emphasized after in utero exposure to caffeine and coincides with an increased Fos expression in the area postrema and nucleus raphe obscurus, two structures in which it is not increased in the absence of caffeine.	Caffeine	264-272	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-141
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Caffeine	180-188	calsequestrin 1	Mus musculus	46-49
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Caffeine	180-188	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Caffeine	180-188	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Caffeine	180-188	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Caffeine	180-188	calsequestrin 1	Mus musculus	55-58
12429744-10	2003	It is concluded that PACAP-38, through the PAC(1) receptor, acts as a neurotransmitter in human fetal chromaffin cells inducing catecholamine secretion, through nonclassical, recently described, ryanodine/caffeine-sensitive pools, involving a cAMP- and PKA-dependent phosphorylation mechanism.	Caffeine	205-213	adenylate cyclase activating polypeptide 1	Homo sapiens	21-26
14515165-0	2003	Inhibition study of adenosine deaminase by caffeine using spectroscopy and isothermal titration calorimetry.	Caffeine	43-51	adenosine deaminase	Homo sapiens	20-39
12480542-4	2003	Both caffeine-induced and depolarization-induced Ca(2+) release from the SR were increased significantly in the HRC overexpressing cardiomyocytes.	Caffeine	5-13	histidine rich calcium binding protein	Rattus norvegicus	112-115
14515165-1	2003	Kinetic and thermodynamic studies were made on the effect of caffeine on the activity of adenosine deaminase in 50 mM sodium phosphate buffer, pH 7.5, using UV spectrophotometry and isothermal titration calorimetry (ITC).	Caffeine	61-69	adenosine deaminase	Homo sapiens	89-108
12388273-4	2003	After 72 h, the half-time of relaxation from caffeine-induced contracture, an estimate of forward NCX1 activity, was prolonged 1.8-fold (P &lt; 0.003) in myocytes overexpressing PLM compared with control myocytes overexpressing green fluorescent protein alone.	Caffeine	45-53	solute carrier family 8 member A1	Rattus norvegicus	98-102
12388273-4	2003	After 72 h, the half-time of relaxation from caffeine-induced contracture, an estimate of forward NCX1 activity, was prolonged 1.8-fold (P &lt; 0.003) in myocytes overexpressing PLM compared with control myocytes overexpressing green fluorescent protein alone.	Caffeine	45-53	FXYD domain-containing ion transport regulator 1	Rattus norvegicus	178-181
15619608-0	2003	Application of the PKCYP test to predict caffeine clearance mediated by CYP1A2 in a rat acute liver injury model.	Caffeine	41-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	72-78
14674790-12	2003	Normality tests and graphical methods of analysing caffeine clearance supported a non-Gaussian and multicomponent distribution of CYP1A2 activity.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	130-136
12534642-0	2003	Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.	Caffeine	162-170	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43
12534642-0	2003	Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.	Caffeine	162-170	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
12678913-6	2003	Identification of the targets of caffeine and UCN-01 to be key-players of the G(2) checkpoint (ATM/ATR and Chk1, respectively) promoted the search for novel inhibitors of this checkpoint.	Caffeine	33-41	ATM serine/threonine kinase	Homo sapiens	95-98
12678913-6	2003	Identification of the targets of caffeine and UCN-01 to be key-players of the G(2) checkpoint (ATM/ATR and Chk1, respectively) promoted the search for novel inhibitors of this checkpoint.	Caffeine	33-41	ATR serine/threonine kinase	Homo sapiens	99-102
12678913-6	2003	Identification of the targets of caffeine and UCN-01 to be key-players of the G(2) checkpoint (ATM/ATR and Chk1, respectively) promoted the search for novel inhibitors of this checkpoint.	Caffeine	33-41	checkpoint kinase 1	Homo sapiens	107-111
15619608-5	2003	In this study, we estimated the amount of CYP1A2 in CCl(4)-treated rats by using acetanilide and caffeine as a probe and a model drug, respectively.	Caffeine	97-105	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	42-48
15619608-8	2003	Moreover, the clearance of caffeine mediated by CYP1A2 in CCl(4)-treated rats was estimated as 0.47+/-0.05 mL/min/kg by using the predicted amount of CYP1A2.	Caffeine	27-35	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	48-54
15619608-8	2003	Moreover, the clearance of caffeine mediated by CYP1A2 in CCl(4)-treated rats was estimated as 0.47+/-0.05 mL/min/kg by using the predicted amount of CYP1A2.	Caffeine	27-35	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	150-156
14705850-0	2003	Massive caffeine overdose requiring vasopressin infusion and hemodialysis.	Caffeine	8-16	arginine vasopressin	Homo sapiens	36-47
14705850-2	2003	We describe the highest-reported serum concentration of caffeine in a patient who survived and discuss the first-reported use of vasopressin and hemodialysis in a caffeine-poisoned patient.	Caffeine	163-171	arginine vasopressin	Homo sapiens	129-140
14705850-7	2003	CONCLUSION: Hemodialysis and vasopressin infusions may be of benefit in the management of caffeine-intoxicated patients who fail to respond to standard therapies.	Caffeine	90-98	arginine vasopressin	Homo sapiens	29-40
14521986-0	2003	Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat.	Caffeine	19-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
12535533-3	2003	The checkpoint is abrogated by caffeine and requires ATR, but not ATM, protein kinase.	Caffeine	31-39	ATR serine/threonine kinase L homeolog	Xenopus laevis	53-56
12925300-10	2003	These preliminary data suggest a modest positive association of caffeine and coffee consumption with the OR for ovarian cancer that may be modified by CYP1A2 genotype and exposures, such as cruciferous vegetable consumption, that influence CYP1A2 expression.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	151-157
14521986-0	2003	Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat.	Caffeine	19-27	hypocretin neuropeptide precursor	Rattus norvegicus	55-61
14521986-2	2003	Orexin (hypocretin)-containing neurons play a critical role in arousal and might be activated by acute administration of caffeine.	Caffeine	121-129	hypocretin neuropeptide precursor	Rattus norvegicus	0-6
14521986-7	2003	Compared with saline, all doses of caffeine increased the number of cells immunoreactive for both orexin and c-Fos.	Caffeine	35-43	hypocretin neuropeptide precursor	Rattus norvegicus	98-104
14521986-7	2003	Compared with saline, all doses of caffeine increased the number of cells immunoreactive for both orexin and c-Fos.	Caffeine	35-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-114
14521986-10	2003	In contrast, caffeine significantly increased the number of non-orexin-immunoreactive neurons expressing c-Fos only in the dorsomedial nucleus.	Caffeine	13-21	hypocretin neuropeptide precursor	Rattus norvegicus	64-70
14521986-10	2003	In contrast, caffeine significantly increased the number of non-orexin-immunoreactive neurons expressing c-Fos only in the dorsomedial nucleus.	Caffeine	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-110
14521986-11	2003	These results indicate that systemically administered caffeine preferentially activates orexin neurons over non-orexin neurons in the same field, and that this activation is most pronounced in the perifornical region where orexin neurons are most concentrated.	Caffeine	54-62	hypocretin neuropeptide precursor	Rattus norvegicus	88-94
14521986-11	2003	These results indicate that systemically administered caffeine preferentially activates orexin neurons over non-orexin neurons in the same field, and that this activation is most pronounced in the perifornical region where orexin neurons are most concentrated.	Caffeine	54-62	hypocretin neuropeptide precursor	Rattus norvegicus	112-118
14521986-11	2003	These results indicate that systemically administered caffeine preferentially activates orexin neurons over non-orexin neurons in the same field, and that this activation is most pronounced in the perifornical region where orexin neurons are most concentrated.	Caffeine	54-62	hypocretin neuropeptide precursor	Rattus norvegicus	112-118
14521986-12	2003	The activation of orexin neurons might play a role in the behavioural activation by caffeine.	Caffeine	84-92	hypocretin neuropeptide precursor	Rattus norvegicus	18-24
12925300-10	2003	These preliminary data suggest a modest positive association of caffeine and coffee consumption with the OR for ovarian cancer that may be modified by CYP1A2 genotype and exposures, such as cruciferous vegetable consumption, that influence CYP1A2 expression.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	240-246
12451139-7	2002	Similarly, depletion of intracellular calcium stores with thapsigargin and treatment with dantrolene, an inhibitor of calcium release from caffeine-ryanodine-sensitive stores, markedly inhibited activity-dependent BDNF release.	Caffeine	139-147	brain-derived neurotrophic factor	Rattus norvegicus	214-218
12505289-6	2002	CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay.	Caffeine	20-28	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
12505289-6	2002	CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay.	Caffeine	20-28	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	115-121
12505289-6	2002	CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay.	Caffeine	217-225	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
12500987-6	2002	Plasma (caffeine) was significantly higher during Caf (0.43 +/- 0.56 and 1.11 +/- 1.78 mM pre vs. post Pl; and 47.32 +/- 12.01 and 72.43 +/- 29.08 mM pre vs. post Caf).	Caffeine	8-16	lysine acetyltransferase 2B	Homo sapiens	50-53
12500987-6	2002	Plasma (caffeine) was significantly higher during Caf (0.43 +/- 0.56 and 1.11 +/- 1.78 mM pre vs. post Pl; and 47.32 +/- 12.01 and 72.43 +/- 29.08 mM pre vs. post Caf).	Caffeine	8-16	lysine acetyltransferase 2B	Homo sapiens	163-166
12490133-2	2002	Caffeine has previously been shown to activate CYP3A activity in vitro and to increase APAP hepatotoxicity in rodents pretreated with prototypic inducers of CYP3A.	Caffeine	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	47-52
12446774-5	2002	Pretreatment of normal and AT fibroblasts with caffeine or UCN-01, inhibitors of ATR (AT mutated and Rad3 related) and Chk1, respectively, abolished the S checkpoint response to UVC.	Caffeine	47-55	ATR serine/threonine kinase	Homo sapiens	81-84
12446774-5	2002	Pretreatment of normal and AT fibroblasts with caffeine or UCN-01, inhibitors of ATR (AT mutated and Rad3 related) and Chk1, respectively, abolished the S checkpoint response to UVC.	Caffeine	47-55	ATM serine/threonine kinase	Homo sapiens	86-105
12446774-5	2002	Pretreatment of normal and AT fibroblasts with caffeine or UCN-01, inhibitors of ATR (AT mutated and Rad3 related) and Chk1, respectively, abolished the S checkpoint response to UVC.	Caffeine	47-55	checkpoint kinase 1	Homo sapiens	119-123
12451287-0	2002	Influence of the urine flow rate on some caffeine metabolite ratios used to assess CYP1A2 activity.	Caffeine	41-49	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-89
12451287-3	2002	Samples of urine were analyzed by high-performance liquid chromatography (HPLC) to quantify caffeine and metabolites used to calculate the different caffeine MRs. MR1, MR3, and MR4 were enhanced after treatment; the percentage of change was inversely associated with that of the urine flow, with r values of -0.48, -0.49, and -0.47, respectively.	Caffeine	149-157	major histocompatibility complex, class I-related	Homo sapiens	163-166
12451287-7	2002	Consistently, ratios containing caffeine (MR1, MR3, and MR4) were highly influenced by the rate of urine excretion, since the flow dependence of their numerators is not canceled out by that of caffeine in their denominators.	Caffeine	32-40	major histocompatibility complex, class I-related	Homo sapiens	42-45
12451287-8	2002	The dependency of the caffeine excretion on renal factors may explain the opposite results found with the different ratios in the aforementioned prospective study of drug interaction, the absence of closer correlations of the five MRs to each other, the discrepancies about the type of frequency distribution of the different MRs (either normal or multimodal), and the higher sensitivity of MR2 to detect gender differences in CYP1A2 activity found in this study.	Caffeine	22-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	427-433
12490133-8	2002	The results indicate that CYP3A is responsible for the caffeine-mediated stimulation of APAP toxicity.	Caffeine	55-63	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	26-31
12490133-2	2002	Caffeine has previously been shown to activate CYP3A activity in vitro and to increase APAP hepatotoxicity in rodents pretreated with prototypic inducers of CYP3A.	Caffeine	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	157-162
12490133-5	2002	These findings suggest that even small increases in CYP3A are sufficient to support caffeine-enhanced APAP toxicity.	Caffeine	84-92	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	52-57
12425947-4	2002	after 60 min of habituation and locomotion was monitored for 3 h. Prnp(O/O) mice presented a diminished hyperlocomotor response to MK-801 treatment but normal response to amphetamine and caffeine compared to wild type mice.	Caffeine	187-195	prion protein	Mus musculus	66-70
12223488-2	2002	Here, we demonstrate that Homer proteins also physically associate with ryanodine receptors type 1 (RyR1) and regulate gating responses to Ca(2+), depolarization, and caffeine.	Caffeine	167-175	ryanodine receptor 1	Homo sapiens	72-104
12324472-4	2002	HEK293 cells expressing both RyR2(wt) and RyR2(D4365-GFP) cDNAs showed caffeine- and ryanodine-sensitive calcium release, demonstrating that both wild type and modified RyR2s form functional calcium release channels.	Caffeine	71-79	ryanodine receptor 2	Homo sapiens	29-33
12324472-4	2002	HEK293 cells expressing both RyR2(wt) and RyR2(D4365-GFP) cDNAs showed caffeine- and ryanodine-sensitive calcium release, demonstrating that both wild type and modified RyR2s form functional calcium release channels.	Caffeine	71-79	ryanodine receptor 2	Homo sapiens	42-46
12324472-4	2002	HEK293 cells expressing both RyR2(wt) and RyR2(D4365-GFP) cDNAs showed caffeine- and ryanodine-sensitive calcium release, demonstrating that both wild type and modified RyR2s form functional calcium release channels.	Caffeine	71-79	ryanodine receptor 2	Homo sapiens	42-46
12427424-0	2002	Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation.	Caffeine	54-62	adenosine A2a receptor	Canis lupus familiaris	66-90
12427424-1	2002	OBJECTIVES: The study was done to determine the effects of propranolol, enalaprilat, verapamil, and caffeine on the vasodilatory properties of the adenosine A(2A)-receptor agonist ATL-146e (ATL).	Caffeine	100-108	adenosine A2a receptor	Canis lupus familiaris	147-171
12376329-8	2002	Hepatic CYP1A2 and CYP3A4 activities were assessed by the caffeine and erythromycin breath tests, respectively.	Caffeine	58-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	19-25
12458710-0	2002	Simultaneous determination of paracetamol and caffeine by flow injection-solid phase spectrometry using C18 silica gel as a sensing support.	Caffeine	46-54	Bardet-Biedl syndrome 9	Homo sapiens	104-107
12445035-4	2002	CYP1A2 activity was determined on three occasions, namely on day 1, day 9 and day 16 using the caffeine plasma index (the ratio of the concentrations of paraxanthine to caffeine), 6 h after oral administration of 200 mg caffeine.	Caffeine	95-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
12445035-4	2002	CYP1A2 activity was determined on three occasions, namely on day 1, day 9 and day 16 using the caffeine plasma index (the ratio of the concentrations of paraxanthine to caffeine), 6 h after oral administration of 200 mg caffeine.	Caffeine	169-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
12433517-1	2002	Coffee is a major source of caffeine, which has been shown to acutely reduce sensitivity to insulin, but also has potentially beneficial effects.	Caffeine	28-36	insulin	Homo sapiens	92-99
12445035-4	2002	CYP1A2 activity was determined on three occasions, namely on day 1, day 9 and day 16 using the caffeine plasma index (the ratio of the concentrations of paraxanthine to caffeine), 6 h after oral administration of 200 mg caffeine.	Caffeine	169-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
12445035-5	2002	RESULTS: There was a significant difference (P = 0.002) between the caffeine ratios for CYP1A2*1F/CYP1A2*1F and CYP1A2*1C/CYP1A2*1F genotypes on day 9, but not on day 1 or day 16 (P &gt; 0.05).	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94
12445035-5	2002	RESULTS: There was a significant difference (P = 0.002) between the caffeine ratios for CYP1A2*1F/CYP1A2*1F and CYP1A2*1C/CYP1A2*1F genotypes on day 9, but not on day 1 or day 16 (P &gt; 0.05).	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
12445035-5	2002	RESULTS: There was a significant difference (P = 0.002) between the caffeine ratios for CYP1A2*1F/CYP1A2*1F and CYP1A2*1C/CYP1A2*1F genotypes on day 9, but not on day 1 or day 16 (P &gt; 0.05).	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
12445035-5	2002	RESULTS: There was a significant difference (P = 0.002) between the caffeine ratios for CYP1A2*1F/CYP1A2*1F and CYP1A2*1C/CYP1A2*1F genotypes on day 9, but not on day 1 or day 16 (P &gt; 0.05).	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
12397042-9	2002	Caffeine potentiated the effect of DDAVP and PGE(2) to increase the levels of phosphorylated extracellular signal-regulated kinase (P-ERK).	Caffeine	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	132-137
12439645-0	2002	Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine.	Caffeine	169-177	adrenoceptor beta 3	Homo sapiens	42-62
12439645-12	2002	The increased expression of the beta(3)-adrenoceptor in obese subjects treated with caffeine and ephedrine supports the potential of beta(3)-adrenoceptor agonists in the treatment of obesity and type 2 diabetes.	Caffeine	84-92	adrenoceptor beta 3	Homo sapiens	32-52
12397635-5	2002	METHODS: In this case-control study of 45 mothers of orofacial cleft children, 39 mothers of spina bifida children and 73 control mothers, NAT2 acetylator status was determined by measuring urinary caffeine metabolites.	Caffeine	198-206	N-acetyltransferase 2	Homo sapiens	139-143
12439645-12	2002	The increased expression of the beta(3)-adrenoceptor in obese subjects treated with caffeine and ephedrine supports the potential of beta(3)-adrenoceptor agonists in the treatment of obesity and type 2 diabetes.	Caffeine	84-92	adrenoceptor beta 3	Homo sapiens	133-153
12439769-6	2002	Sal increased basal blood glucose and both Sal and Caf induced significant higher plasma insulin concentrations at rest, at the end of the mock test and during the recovery compared to Pla.	Caffeine	51-54	insulin	Homo sapiens	89-96
12439084-10	2002	RPE was also lower at 90 s in the caffeine treatment (13.8 +/- 1.8 RPE points) in comparison with baseline (14.6 +/- 1.9 RPE points).	Caffeine	34-42	ribulose-5-phosphate-3-epimerase	Homo sapiens	0-3
12439084-10	2002	RPE was also lower at 90 s in the caffeine treatment (13.8 +/- 1.8 RPE points) in comparison with baseline (14.6 +/- 1.9 RPE points).	Caffeine	34-42	ribulose-5-phosphate-3-epimerase	Homo sapiens	67-70
12439084-10	2002	RPE was also lower at 90 s in the caffeine treatment (13.8 +/- 1.8 RPE points) in comparison with baseline (14.6 +/- 1.9 RPE points).	Caffeine	34-42	ribulose-5-phosphate-3-epimerase	Homo sapiens	67-70
12439084-11	2002	CONCLUSION: As indicated by a greater T(lim), acute caffeine ingestion was found to be ergogenic after 6-d of creatine supplementation and caffeine abstinence.	Caffeine	52-60	PDZ and LIM domain 5	Homo sapiens	40-43
12213830-6	2002	Interactions between RyR isoforms were further assessed by complementation analysis using mutants RyR2 (I4827T), RyR2 (E3987A), RyR3 (I4732T), RyR3 (E3885A), and RyR1 (E4032A), all of which are deficient in caffeine response.	Caffeine	207-215	ryanodine receptor 1	Homo sapiens	21-24
12448526-3	2002	The concentrated caffeine was separated using a C18 column with a gradient of water-acetonitrile and detected by diode array detection (DAD) at 210 nm.	Caffeine	17-25	Bardet-Biedl syndrome 9	Homo sapiens	48-51
12381785-7	2002	Likewise, inositol 1,4,5-trisphosphate (IP(3)) receptor antagonists xestospongin C and caffeine selectively blocked the second phase, but not the initiation of insulin signaling.	Caffeine	87-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-55
12154088-5	2002	We found an activation of Nek11 kinase activity when cells were treated with various DNA-damaging agents and replication inhibitors, and this activation of Nek11 was suppressed by caffeine in HeLaS3 cells.	Caffeine	180-188	NIMA related kinase 11	Homo sapiens	26-31
12395097-6	2002	The pro-apoptotic protease caspase-3 was activated to mediate neuronal death following exposure to caffeine.	Caffeine	99-107	caspase 3	Rattus norvegicus	27-36
12395097-7	2002	The present findings suggest that caffeine may cause caspase-3-dependent neuronal cell apoptosis in neonatal rat as well as.	Caffeine	34-42	caspase 3	Rattus norvegicus	53-62
12154088-5	2002	We found an activation of Nek11 kinase activity when cells were treated with various DNA-damaging agents and replication inhibitors, and this activation of Nek11 was suppressed by caffeine in HeLaS3 cells.	Caffeine	180-188	NIMA related kinase 11	Homo sapiens	156-161
12154088-7	2002	Collectively, these results suggest that Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway.	Caffeine	102-110	NIMA related kinase 11	Homo sapiens	41-46
12356735-7	2002	Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	25-28
12145276-7	2002	In CHO-IR cells and rat soleus muscle, theophylline and caffeine block the ability of insulin to stimulate protein kinase B with IC(50) values similar to those for inhibition of PI3K activity, whereas insulin stimulation of ERK1 or ERK2 was not inhibited at concentrations up to 10 mm.	Caffeine	56-64	mitogen activated protein kinase 1	Rattus norvegicus	232-236
12356735-7	2002	Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization.	Caffeine	0-8	ataxia telangiectasia mutated	Mus musculus	74-77
12356735-7	2002	Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization.	Caffeine	0-8	ataxia telangiectasia and Rad3 related	Mus musculus	78-81
12356735-7	2002	Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization.	Caffeine	0-8	checkpoint kinase 2	Mus musculus	96-100
12356735-7	2002	Caffeine further reduced p53 accumulation, suggesting the existence of an ATM/ATR-dependent but Chk2-independent pathway for p53 stabilization.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	125-128
12151923-2	2002	This study was designed to investigate the effects of different mutations in the RYR1 gene on contracture development in in vitro contracture tests (IVCT) with halothane, caffeine, and ryanodine.	Caffeine	171-179	ryanodine receptor 1	Homo sapiens	81-85
12411982-6	2002	We found a striking inverse relationship between both TNF-alpha and IL-6 plasma concentrations and the activity of CYP2C19; metabolism of caffeine (CYP1A2) also had a negative association with IL-6 plasma concentrations.	Caffeine	138-146	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	115-122
12411982-6	2002	We found a striking inverse relationship between both TNF-alpha and IL-6 plasma concentrations and the activity of CYP2C19; metabolism of caffeine (CYP1A2) also had a negative association with IL-6 plasma concentrations.	Caffeine	138-146	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	148-154
12411982-6	2002	We found a striking inverse relationship between both TNF-alpha and IL-6 plasma concentrations and the activity of CYP2C19; metabolism of caffeine (CYP1A2) also had a negative association with IL-6 plasma concentrations.	Caffeine	138-146	interleukin 6	Homo sapiens	193-197
12356882-10	2002	Both of these effects may contribute to increased sensitivity of the RYR to caffeine and volatile anaesthetics.	Caffeine	76-84	ryanodine receptor 1	Homo sapiens	69-72
12351160-7	2002	A subgroup of 349 cases and 467 controls was phenotyped for CYP1A2 by a caffeine test.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
12209584-7	2002	Partial abrogation of G2/M arrest by caffeine enhanced apoptosis in both hMLH1(+) and hMLH1(-) cells.	Caffeine	37-45	mutL homolog 1	Homo sapiens	73-78
12209584-7	2002	Partial abrogation of G2/M arrest by caffeine enhanced apoptosis in both hMLH1(+) and hMLH1(-) cells.	Caffeine	37-45	mutL homolog 1	Homo sapiens	86-91
12204845-5	2002	In the RLS-affected patients, regular use or overuse of non-opioid analgesics frequently combined with caffeine was the major risk factor which significantly correlated with psychiatric and medical comorbidity.	Caffeine	103-111	RLS1	Homo sapiens	7-10
12169647-6	2002	In addition, the R4496C mutation enhanced the sensitivity of RyR2 to activation by Ca2+ and by caffeine.	Caffeine	95-103	ryanodine receptor 2	Homo sapiens	61-65
12378022-4	2002	In addition, caffeine was shown to increase the caspase-3 activity.	Caffeine	13-21	caspase 3	Homo sapiens	48-57
12378022-5	2002	These results suggest that high-dose of caffeine induces apoptosis in human neuroblastoma cells, probably by increasing the caspase-3 enzyme activity.	Caffeine	40-48	caspase 3	Homo sapiens	124-133
12205293-5	2002	Immunohistochemical analysis showed that topical applications of caffeine or EGCG increased apoptosis as measured by the number of caspase 3-positive cells in nonmalignant skin tumors by 87% or 72%, respectively, and in squamous cell carcinomas by 92% or 56%, respectively, but there was no effect on apoptosis in nontumor areas of the epidermis.	Caffeine	65-73	caspase 3	Mus musculus	131-140
12181566-0	2002	Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.	Caffeine	67-75	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	15-23
12181566-3	2002	Here we show that the stimulatory effect of caffeine on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000).	Caffeine	44-52	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	129-137
12181566-6	2002	In support of a role for DARPP-32 in the action of caffeine, we found that, in striata of intact mice, caffeine increased the state of phosphorylation of DARPP-32 at Thr 75.	Caffeine	51-59	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	25-33
12181566-6	2002	In support of a role for DARPP-32 in the action of caffeine, we found that, in striata of intact mice, caffeine increased the state of phosphorylation of DARPP-32 at Thr 75.	Caffeine	51-59	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	154-162
12181566-6	2002	In support of a role for DARPP-32 in the action of caffeine, we found that, in striata of intact mice, caffeine increased the state of phosphorylation of DARPP-32 at Thr 75.	Caffeine	103-111	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	25-33
12181566-6	2002	In support of a role for DARPP-32 in the action of caffeine, we found that, in striata of intact mice, caffeine increased the state of phosphorylation of DARPP-32 at Thr 75.	Caffeine	103-111	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	154-162
12181566-7	2002	Caffeine increased Thr 75 phosphorylation through inhibition of PP-2A-catalysed dephosphorylation, rather than through stimulation of cyclin-dependent kinase 5 (Cdk5)-catalysed phosphorylation, of this residue.	Caffeine	0-8	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	64-69
12181566-8	2002	Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine.	Caffeine	133-141	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	55-63
12151923-10	2002	CONCLUSIONS: The differences between the groups in the halothane and caffeine IVCT threshold concentrations and in the time course of contracture development in the ryanodine IVCT underline the hypothesis that certain mutations in the RYR1 gene could make the ryanodine receptor more sensitive to specific ligands.	Caffeine	69-77	ryanodine receptor 1	Homo sapiens	235-239
12124989-8	2002	RYR1 mutations associated with both CCD and MH (R163C, R2163H, R2435H) had more severe caffeine and halothane response phenotypes than those associated with MH alone.	Caffeine	87-95	ryanodine receptor 1	Homo sapiens	0-4
12189367-9	2002	CONCLUSIONS: Our results suggest that putative poor metabolizers of xanthine oxidase activities exist in a Japanese population and that a decreased 1,7-dimethyluric acid formation from caffeine in poor metabolizers of CYP2A6 appears to affect the metabolic ratio used for the assessment of CYP1A2 activity.	Caffeine	185-193	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	218-224
12189367-9	2002	CONCLUSIONS: Our results suggest that putative poor metabolizers of xanthine oxidase activities exist in a Japanese population and that a decreased 1,7-dimethyluric acid formation from caffeine in poor metabolizers of CYP2A6 appears to affect the metabolic ratio used for the assessment of CYP1A2 activity.	Caffeine	185-193	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	290-296
12189363-2	2002	We compared the performance of several modifications of the caffeine test for measurement of CYP1A2 activity in subjects with exceptionally high, low, or absent enzyme induction.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99
12220451-4	2002	In this report we show that myotubes derived from individuals carrying the RyR1 Thr2206Met (C6617T) mutation have an abnormal response of the intracellular calcium concentration to 4-chloro-m-cresol and to caffeine.	Caffeine	206-214	ryanodine receptor 1	Homo sapiens	75-79
12172216-0	2002	The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-78
12153486-0	2002	Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats.	Caffeine	71-79	adenosine A1 receptor	Rattus norvegicus	0-21
12153486-1	2002	Pregnant rats were treated daily with 1 g/L of caffeine or theophylline in their drinking water during pregnancy and the effect of these methylxanthines on adenosine A1 receptor was assayed using binding and reverse transcription polymerase chain reaction (RT-PCR) assays in brains from both mothers and full-term fetuses.	Caffeine	47-55	adenosine A1 receptor	Rattus norvegicus	156-177
12153486-8	2002	These results suggest that maternal caffeine or theophylline intake modulates adenosine A1 receptor, causing a down-regulation of adenosine A1 receptor in brain in both mothers and fetuses.	Caffeine	36-44	adenosine A1 receptor	Rattus norvegicus	78-99
12153486-8	2002	These results suggest that maternal caffeine or theophylline intake modulates adenosine A1 receptor, causing a down-regulation of adenosine A1 receptor in brain in both mothers and fetuses.	Caffeine	36-44	adenosine A1 receptor	Rattus norvegicus	130-151
12118071-7	2002	DNA replication was almost completely inhibited in the presence of EcoRI and the inhibition was sensitive to caffeine, an inhibitor of ataxia telangiectasia mutated protein (ATM) and ATM- and Rad3-related protein (ATR).	Caffeine	109-117	ATM serine/threonine kinase L homeolog	Xenopus laevis	135-172
12118071-7	2002	DNA replication was almost completely inhibited in the presence of EcoRI and the inhibition was sensitive to caffeine, an inhibitor of ataxia telangiectasia mutated protein (ATM) and ATM- and Rad3-related protein (ATR).	Caffeine	109-117	ATM serine/threonine kinase L homeolog	Xenopus laevis	174-177
12118071-7	2002	DNA replication was almost completely inhibited in the presence of EcoRI and the inhibition was sensitive to caffeine, an inhibitor of ataxia telangiectasia mutated protein (ATM) and ATM- and Rad3-related protein (ATR).	Caffeine	109-117	ATR serine/threonine kinase L homeolog	Xenopus laevis	183-212
12118071-7	2002	DNA replication was almost completely inhibited in the presence of EcoRI and the inhibition was sensitive to caffeine, an inhibitor of ataxia telangiectasia mutated protein (ATM) and ATM- and Rad3-related protein (ATR).	Caffeine	109-117	ATR serine/threonine kinase L homeolog	Xenopus laevis	214-217
12101227-6	2002	Additionally, E2F1-mediated apoptosis is abolished in the presence of caffeine, an inhibitor of phosphatidylinositol 3-kinase-related kinases that phosphorylate p53.	Caffeine	70-78	E2F transcription factor 1	Mus musculus	14-18
12101227-6	2002	Additionally, E2F1-mediated apoptosis is abolished in the presence of caffeine, an inhibitor of phosphatidylinositol 3-kinase-related kinases that phosphorylate p53.	Caffeine	70-78	transformation related protein 53, pseudogene	Mus musculus	161-164
12172216-1	2002	This study investigated the role of genetic factors (CYP1A2) in caffeine metabolism.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	53-59
12172216-2	2002	The CYP1A2 activity was determined in 378 Danish twins following oral intake of a single dose of 200 mg caffeine and subsequent determination of the caffeine ratio (AFMU+1MU+1MX)/17DMU in a 6-h urine sample.	Caffeine	104-112	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
12172216-2	2002	The CYP1A2 activity was determined in 378 Danish twins following oral intake of a single dose of 200 mg caffeine and subsequent determination of the caffeine ratio (AFMU+1MU+1MX)/17DMU in a 6-h urine sample.	Caffeine	149-157	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
12060097-11	2002	Following treatment with caffeine, the expression of alpha1- and beta1-subunits of Na+/K+-ATPase, as well as that of NHE3, was decreased.	Caffeine	25-33	solute carrier family 9 member A3	Rattus norvegicus	117-121
12055093-4	2002	Insulin-stimulated leptin secretion could also be inhibited by a series of agents increasing intracellular cAMP levels, such as lipolytic hormones (ACTH and thyrotropin-stimulating hormone), various nonhydrolyzable cAMP analogs, pertussis toxin, forskolin, methylxanthines (caffeine, theophylline, IBMX), and specific inhibitors of phosphodiesterase III (imazodan, milrinone, and amrinone).	Caffeine	274-282	leptin	Rattus norvegicus	19-25
12100222-6	2002	RESULTS: Mean caffeine concentrations varied from 10 to 20 mg l-1 throughout treatment (range 3.6-28.4 mg l-1).	Caffeine	14-22	immunoglobulin kappa variable 1-16	Homo sapiens	62-65
12100222-6	2002	RESULTS: Mean caffeine concentrations varied from 10 to 20 mg l-1 throughout treatment (range 3.6-28.4 mg l-1).	Caffeine	14-22	immunoglobulin kappa variable 1-16	Homo sapiens	106-109
12429947-5	2002	Potentiation of PMA-mediated apoptosis was partially mimicked by caffeine suggesting the involvement of Chk1 in the potentiation of apoptosis.	Caffeine	65-73	checkpoint kinase 1	Homo sapiens	104-108
12482208-9	2002	RESULTS: When the active groups were compared with the episodic migraine group, the following associations were found: 1) ARH: hypertension and daily consumption of caffeine; 2) CM: allergies, asthma, hypothyroidism, hypertension, and daily consumption of caffeine; and 3) NDPH: allergies, asthma, hypothyroidism, and consumption of alcohol more than three times per week.	Caffeine	165-173	low density lipoprotein receptor adaptor protein 1	Homo sapiens	122-125
12072573-5	2002	ET-1 potentiation of 80K-induced [Ca2+]m responses by decreased sarcoplasmic reticulum (SR) buffering of [Ca2+]m or Ca2+-induced Ca2+ release was ruled out by lack of potentiation by 5 mM caffeine and 1 microM thapsigargin.	Caffeine	188-196	endothelin 1	Homo sapiens	0-4
12060097-18	2002	It is suggested that caffeine decreases Na+/K+-ATPase and NHE3 activities and increases nitric oxide and ANP activities in the kidney.	Caffeine	21-29	solute carrier family 9 member A3	Rattus norvegicus	58-62
12060097-18	2002	It is suggested that caffeine decreases Na+/K+-ATPase and NHE3 activities and increases nitric oxide and ANP activities in the kidney.	Caffeine	21-29	natriuretic peptide A	Rattus norvegicus	105-108
12110375-0	2002	Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.	Caffeine	15-23	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	77-83
12045220-4	2002	Ca2+ release experiments showed that transfected RyR1 and RyR3 channels responded to caffeine, although with different sensitivity, generating a global release of Ca2+ from the entire endoplasmic reticulum.	Caffeine	85-93	carbonic anhydrase 2	Homo sapiens	0-3
12045220-4	2002	Ca2+ release experiments showed that transfected RyR1 and RyR3 channels responded to caffeine, although with different sensitivity, generating a global release of Ca2+ from the entire endoplasmic reticulum.	Caffeine	85-93	ryanodine receptor 1	Homo sapiens	49-53
12045220-4	2002	Ca2+ release experiments showed that transfected RyR1 and RyR3 channels responded to caffeine, although with different sensitivity, generating a global release of Ca2+ from the entire endoplasmic reticulum.	Caffeine	85-93	ryanodine receptor 3	Homo sapiens	58-62
12045220-4	2002	Ca2+ release experiments showed that transfected RyR1 and RyR3 channels responded to caffeine, although with different sensitivity, generating a global release of Ca2+ from the entire endoplasmic reticulum.	Caffeine	85-93	carbonic anhydrase 2	Homo sapiens	163-166
12110375-6	2002	In wild-type and CYP1A2-null mice LM, the main caffeine metabolite was 1,3,7-trimethylurate, but formation was not saturable.	Caffeine	47-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	17-23
12110375-7	2002	Apparent K(M) for paraxanthine formation from caffeine in wild-type and CYP1A2-null murine LM were 0.2 and 4.9 mmol L(-1), respectively.	Caffeine	46-54	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	72-78
12034347-4	2002	SIN-1 Also reduced the amplitude of caffeine-induced Ca(2+) transients, and the increase in I(Ca,L) induced by isoproterenol.	Caffeine	36-44	MAPK associated protein 1	Homo sapiens	0-5
12121694-9	2002	Caffeine (10(-5) M) and EHNA increased the CCK-8 dose-response contractions.	Caffeine	0-8	cholecystokinin	Homo sapiens	43-46
12121694-13	2002	Caffeine also increases CCK-induced gallbladder contractions via type II PDE pathways.	Caffeine	0-8	cholecystokinin	Homo sapiens	24-27
11934664-4	2002	We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor (MEF)2A and MEF2D, which are transcription factors involved in regulating GLUT4 expression.	Caffeine	71-79	solute carrier family 2 member 4	Rattus norvegicus	124-129
12015346-2	2002	However, epinephrine, a potent inhibitor of insulin actions, is increased after caffeine ingestion.	Caffeine	80-88	insulin	Homo sapiens	44-51
12015346-3	2002	We tested the hypothesis that the insulin antagonistic effects of caffeine are mediated by epinephrine, and not by AR antagonism, in seven healthy men.	Caffeine	66-74	insulin	Homo sapiens	34-41
12015346-7	2002	Areas under the insulin and C-peptide curves were 42 and 39% greater (P &lt; 0.05), respectively, in CAF than in PL, PR, and CAF + PR.	Caffeine	101-104	insulin	Homo sapiens	16-23
12008149-6	2002	The results are discussed in relation to the mechanism of deformylation and the use of caffeine as a probe drug for NAT2 phenotyping.	Caffeine	87-95	N-acetyltransferase 2	Homo sapiens	116-120
12072455-5	2002	Although the sth1-3ts mutant exhibits defects characteristic of PKC1 pathway mutants (caffeine and staurosporine sensitivities and an osmoremedial phenotype), only upstream components and not downstream effectors of the PKC1-MAP kinase pathway can suppress defects conferred by sth1-3ts, suggesting that RSC functions in an alternative PKC1-dependent pathway.	Caffeine	86-94	RSC chromatin remodeling complex ATPase subunit STH1	Saccharomyces cerevisiae S288C	13-17
12072455-5	2002	Although the sth1-3ts mutant exhibits defects characteristic of PKC1 pathway mutants (caffeine and staurosporine sensitivities and an osmoremedial phenotype), only upstream components and not downstream effectors of the PKC1-MAP kinase pathway can suppress defects conferred by sth1-3ts, suggesting that RSC functions in an alternative PKC1-dependent pathway.	Caffeine	86-94	protein kinase C	Saccharomyces cerevisiae S288C	64-68
12015346-7	2002	Areas under the insulin and C-peptide curves were 42 and 39% greater (P &lt; 0.05), respectively, in CAF than in PL, PR, and CAF + PR.	Caffeine	125-128	insulin	Homo sapiens	16-23
12015346-9	2002	These data suggest that the insulin antagonistic effects of caffeine in vivo are mediated by elevated epinephrine rather than by peripheral AR antagonism.	Caffeine	60-68	insulin	Homo sapiens	28-35
11934664-4	2002	We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor (MEF)2A and MEF2D, which are transcription factors involved in regulating GLUT4 expression.	Caffeine	71-79	myocyte enhancer factor 2a	Rattus norvegicus	170-176
11934664-4	2002	We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor (MEF)2A and MEF2D, which are transcription factors involved in regulating GLUT4 expression.	Caffeine	71-79	myocyte enhancer factor 2D	Rattus norvegicus	181-186
11934664-4	2002	We found that raising cytosolic Ca(2+) by exposing L6 myotubes to 5 mM caffeine for 3 h/day for 5 days induced increases in GLUT4 protein and in myocyte enhancer factor (MEF)2A and MEF2D, which are transcription factors involved in regulating GLUT4 expression.	Caffeine	71-79	solute carrier family 2 member 4	Rattus norvegicus	243-248
11934664-5	2002	The caffeine-induced increases in GLUT4 and MEF2A and MEF2D were partially blocked by dantrolene, an inhibitor of sarcoplasmic reticulum Ca(2+) release, and completely blocked by KN93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase (CAMK).	Caffeine	4-12	solute carrier family 2 member 4	Rattus norvegicus	34-39
11934664-5	2002	The caffeine-induced increases in GLUT4 and MEF2A and MEF2D were partially blocked by dantrolene, an inhibitor of sarcoplasmic reticulum Ca(2+) release, and completely blocked by KN93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase (CAMK).	Caffeine	4-12	myocyte enhancer factor 2a	Rattus norvegicus	44-49
11934664-5	2002	The caffeine-induced increases in GLUT4 and MEF2A and MEF2D were partially blocked by dantrolene, an inhibitor of sarcoplasmic reticulum Ca(2+) release, and completely blocked by KN93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase (CAMK).	Caffeine	4-12	myocyte enhancer factor 2D	Rattus norvegicus	54-59
11934664-6	2002	Caffeine also induced increases in MEF2A, MEF2D, and GLUT4 in rat epitrochlearis muscles incubated with caffeine in culture medium.	Caffeine	0-8	myocyte enhancer factor 2a	Rattus norvegicus	35-40
11934664-6	2002	Caffeine also induced increases in MEF2A, MEF2D, and GLUT4 in rat epitrochlearis muscles incubated with caffeine in culture medium.	Caffeine	0-8	myocyte enhancer factor 2D	Rattus norvegicus	42-47
11934664-6	2002	Caffeine also induced increases in MEF2A, MEF2D, and GLUT4 in rat epitrochlearis muscles incubated with caffeine in culture medium.	Caffeine	0-8	solute carrier family 2 member 4	Rattus norvegicus	53-58
11934664-6	2002	Caffeine also induced increases in MEF2A, MEF2D, and GLUT4 in rat epitrochlearis muscles incubated with caffeine in culture medium.	Caffeine	104-112	solute carrier family 2 member 4	Rattus norvegicus	53-58
12010181-2	2002	The hypothesis that caffeine upregulates uncoupling protein (UCP)-1, UCP-2 and UCP-3 expression, which contribute to thermogenesis, was investigated in obese mice.	Caffeine	20-28	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	41-67
11980637-8	2002	Not only caffeine, the nonspecific inhibitor of ATR, or UCN-01, the nonspecific inhibitor of CHK1, but also the specific CHK1 antisense oligonucleotide abolished the stronger inhibition of DNA replication in CPT-treated Ku80-/- cells.	Caffeine	9-17	ATR serine/threonine kinase	Homo sapiens	48-51
12010181-2	2002	The hypothesis that caffeine upregulates uncoupling protein (UCP)-1, UCP-2 and UCP-3 expression, which contribute to thermogenesis, was investigated in obese mice.	Caffeine	20-28	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	69-74
11943493-1	2002	In our study, we observed the activation of in vitro matured pig oocytes and their subsequent parthenogenetic cleavage after stimulation of ryanodine receptors (RyR) using ryanodine (Ry), caffeine or cyclic adenosine diphosphate ribose (cADPri) or after stimulation of inositol triphosphate receptors (IP(3)R) using D-myo-inositol 1,4,5-triphosphate (IP(3)).	Caffeine	188-196	ryanodine receptor 1	Sus scrofa	140-159
12010181-2	2002	The hypothesis that caffeine upregulates uncoupling protein (UCP)-1, UCP-2 and UCP-3 expression, which contribute to thermogenesis, was investigated in obese mice.	Caffeine	20-28	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	79-84
12010181-7	2002	In caffeine-injected obese mice, UCP-1 mRNA levels were significantly increased by 1.5-fold in BAT, UCP-2 mRNA levels were increased by 1.8- and 2.5-fold in BAT and skeletal muscles, respectively, and UCP-3 mRNA levels were increased 1.7- and 3.4-fold in BAT and skeletal muscles, respectively, compared with control mice injected with physiological saline.	Caffeine	3-11	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	33-38
12010181-7	2002	In caffeine-injected obese mice, UCP-1 mRNA levels were significantly increased by 1.5-fold in BAT, UCP-2 mRNA levels were increased by 1.8- and 2.5-fold in BAT and skeletal muscles, respectively, and UCP-3 mRNA levels were increased 1.7- and 3.4-fold in BAT and skeletal muscles, respectively, compared with control mice injected with physiological saline.	Caffeine	3-11	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	100-105
12010181-7	2002	In caffeine-injected obese mice, UCP-1 mRNA levels were significantly increased by 1.5-fold in BAT, UCP-2 mRNA levels were increased by 1.8- and 2.5-fold in BAT and skeletal muscles, respectively, and UCP-3 mRNA levels were increased 1.7- and 3.4-fold in BAT and skeletal muscles, respectively, compared with control mice injected with physiological saline.	Caffeine	3-11	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	201-206
12010181-12	2002	It was concluded that caffeine upregulates the expression of UCP-1, UCP-2 and UCP-3 in BAT and UCP-2 and UCP-3 in skeletal muscles, which may contribute to thermogenesis in obese mice.	Caffeine	22-30	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	61-66
12010181-12	2002	It was concluded that caffeine upregulates the expression of UCP-1, UCP-2 and UCP-3 in BAT and UCP-2 and UCP-3 in skeletal muscles, which may contribute to thermogenesis in obese mice.	Caffeine	22-30	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	68-73
12010181-12	2002	It was concluded that caffeine upregulates the expression of UCP-1, UCP-2 and UCP-3 in BAT and UCP-2 and UCP-3 in skeletal muscles, which may contribute to thermogenesis in obese mice.	Caffeine	22-30	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	78-83
12010181-12	2002	It was concluded that caffeine upregulates the expression of UCP-1, UCP-2 and UCP-3 in BAT and UCP-2 and UCP-3 in skeletal muscles, which may contribute to thermogenesis in obese mice.	Caffeine	22-30	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	95-100
12010181-12	2002	It was concluded that caffeine upregulates the expression of UCP-1, UCP-2 and UCP-3 in BAT and UCP-2 and UCP-3 in skeletal muscles, which may contribute to thermogenesis in obese mice.	Caffeine	22-30	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	105-110
12083739-3	2002	The increase of the intracellular Ca2+ concentration induced by caffeine in CHO cells expressing cardiac-type RyR was suppressed by 9HE in a concentration-dependent manner.	Caffeine	64-72	ryanodine receptor 2	Rattus norvegicus	110-113
12029377-10	2002	However, the RyR2s consistently recovered from Mg2+ block with 100 microM [Ca2+] or caffeine application, but not when ATP was added.	Caffeine	84-92	ryanodine receptor 2	Oryctolagus cuniculus	13-17
12029377-11	2002	Thus, at physiological [Mg2+], RyR2s behaved as relatively homogeneous Ca2+/caffeine-gated HA channels.	Caffeine	76-84	ryanodine receptor 2	Oryctolagus cuniculus	31-35
11994162-4	2002	This strain was sensitive to the presence of caffeine, Calcofluor white and Congo red, all drugs known to affect mutants defective in the signal transduction pathway ensuring cellular integrity in which Pkc1p is a central component.	Caffeine	45-53	protein kinase C	Saccharomyces cerevisiae S288C	203-208
12150202-5	2002	The binding of doxorubicin to RyR2 was specific and displaced by caffeine.	Caffeine	65-73	ryanodine receptor 2	Oryctolagus cuniculus	30-34
12150202-6	2002	Both doxorubicin and caffeine enhanced [3H]-ryanodine binding to RyR2 in a Ca2+ dependent manner.	Caffeine	21-29	ryanodine receptor 2	Oryctolagus cuniculus	65-69
11956503-4	2002	CYP enzyme activities were measured by means of the metabolic ratios of sparteine (CYP2D6), endogenous cortisol metabolism (CYP3A4), and caffeine (CYP1A2), as well as by the S/R ratio of mephenytoin (CYP2C19) and antipyrine clearance.	Caffeine	137-145	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
11927498-0	2002	CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.	Caffeine	30-38	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
11927498-2	2002	CYP2A6 phenotype was determined using caffeine as a probe drug in individuals participating in a case-control study of colorectal cancer (127 cases and 333 controls matched on age, gender, race, and geographic region).	Caffeine	38-46	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
11927498-3	2002	Conversion of the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyl uric acid (17U) is catalyzed primarily by CYP2A6, and this activity can be assayed by comparison of urinary molar ratios of metabolites.	Caffeine	18-26	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	123-129
11927498-10	2002	We found a strong relationship between CYP2A6 activity, measured by urinary caffeine metabolite ratio, and colorectal cancer risk.	Caffeine	76-84	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	39-45
11907488-18	2002	A nontherapeutic oral daily dose of fluvoxamine is sufficient to provide a marked inhibition of both caffeine (CYP1A2) and omeprazole (CYP2C19) metabolism.	Caffeine	101-109	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	111-117
11912127-3	2002	The slow response of S-phase checkpoint, which is resistant to wortmannin, sensitive to caffeine and UCN-01, and related to cyclin-dependent kinase phosphorylation, is much stronger in CHK1 overexpressed cells, and it could be abolished by Chk1 antisense oligonucleotides.	Caffeine	88-96	checkpoint kinase 1	Homo sapiens	185-189
11912127-3	2002	The slow response of S-phase checkpoint, which is resistant to wortmannin, sensitive to caffeine and UCN-01, and related to cyclin-dependent kinase phosphorylation, is much stronger in CHK1 overexpressed cells, and it could be abolished by Chk1 antisense oligonucleotides.	Caffeine	88-96	checkpoint kinase 1	Homo sapiens	240-244
11907488-0	2002	Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-106
11907490-5	2002	RESULTS: The metabolic ratio of caffeine increased significantly in the group that received growth hormone compared with placebo (median difference, 4.55; 95% confidence interval (CI), 1.64 to 8.60; versus -0.90; 95% CI, -5.70 to 1.36), indicating an induction of CYP1A2.	Caffeine	32-40	growth hormone 1	Homo sapiens	92-106
11852053-4	2002	The RyR activators caffeine, FK506, ryanodine and 4-chloro-m-cresol mobilized Ca(2+) in DC, and responses to 4-chloro-m-cresol were inhibited by dantrolene.	Caffeine	19-27	ryanodine receptor 1, skeletal muscle	Mus musculus	4-7
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	insulin	Homo sapiens	37-44
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	glycogen synthase kinase 3 alpha	Homo sapiens	312-322
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	insulin	Homo sapiens	168-175
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	insulin	Homo sapiens	37-44
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	glycogen synthase kinase 3 alpha	Homo sapiens	312-322
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	137-145	insulin	Homo sapiens	168-175
11872654-0	2002	Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.	Caffeine	0-8	insulin	Homo sapiens	31-38
11872654-5	2002	In accordance, the total area under the curve over 100 min (AUC(0--100 min)) for insulin-stimulated glucose uptake in caffeine was reduced (P &lt; 0.05) by approximately 50% in rested and exercised muscle.	Caffeine	118-126	insulin	Homo sapiens	81-88
11872654-7	2002	Exercise increased insulin sensitivity of leg glucose uptake in both caffeine and placebo.	Caffeine	69-77	insulin	Homo sapiens	19-26
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	20-28	insulin	Homo sapiens	37-44
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Caffeine	20-28	insulin	Homo sapiens	168-175
11936218-5	2002	In contrast, all flavonoids tested inhibited hepatic caffeine N"-demethylation (CYP1A2) with IC50 values ranging from 0.7 to 51.3 microM.	Caffeine	53-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
11875368-9	2002	In contrast, NAT2 genotype and CYP1A2 and NAT2 hepatic activity measured by caffeine urinary metabolites were not associated with adenoma risk, although an increase in risk with rapid CYP1A2 activity could not be ruled out (OR = 1.46; 95% CI 0.76-2.81).	Caffeine	76-84	N-acetyltransferase 2	Homo sapiens	42-46
11929532-3	2002	Elevated TOT4 copy number results in an intermediate tot phenotype, which includes mild sensitivities towards caffeine, Calcofluor white and elevated growth temperature, suggesting that TOT4 influences TOT/Elongator function.	Caffeine	110-118	Kti12p	Saccharomyces cerevisiae S288C	9-13
11851639-12	2002	The effects on caffeine N3-demethylation (CYP1A2) and dapsone metabolism suggest that chronic disulfiram administration may affect multiple drug metabolizing enzymes, which could potentially complicate the use of chronically administered disulfiram as a diagnostic inhibitor of CYP2E1.	Caffeine	15-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
11851639-12	2002	The effects on caffeine N3-demethylation (CYP1A2) and dapsone metabolism suggest that chronic disulfiram administration may affect multiple drug metabolizing enzymes, which could potentially complicate the use of chronically administered disulfiram as a diagnostic inhibitor of CYP2E1.	Caffeine	15-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	278-284
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	31-39	ATM serine/threonine kinase	Homo sapiens	50-53
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	31-39	checkpoint kinase 1	Homo sapiens	122-126
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	180-188	ATM serine/threonine kinase	Homo sapiens	50-53
11864911-7	2002	Consistent with a role for the caffeine-sensitive ATM or ATR protein kinase in low-dose BPDE-induced S-phase arrest, both Chk1 phosphorylation and S-phase arrest were abrogated by caffeine.	Caffeine	180-188	checkpoint kinase 1	Homo sapiens	122-126
11864911-10	2002	Overall, our data demonstrate the existence of a caffeine-sensitive, Chk1-mediated, S-phase checkpoint that is operational in response to BPDE.	Caffeine	49-57	checkpoint kinase 1	Homo sapiens	69-73
11851639-4	2002	Activities of the drug metabolizing enzymes CYP1A2, CYP2C19, CYP2D6, CYP2E1 and N-acetyltransferase were determined using the probe drugs caffeine, mephenytoin, debrisoquine, chlorzoxazone, and dapsone, respectively.	Caffeine	138-146	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
11851639-4	2002	Activities of the drug metabolizing enzymes CYP1A2, CYP2C19, CYP2D6, CYP2E1 and N-acetyltransferase were determined using the probe drugs caffeine, mephenytoin, debrisoquine, chlorzoxazone, and dapsone, respectively.	Caffeine	138-146	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	61-67
11851639-4	2002	Activities of the drug metabolizing enzymes CYP1A2, CYP2C19, CYP2D6, CYP2E1 and N-acetyltransferase were determined using the probe drugs caffeine, mephenytoin, debrisoquine, chlorzoxazone, and dapsone, respectively.	Caffeine	138-146	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	69-75
11815511-0	2002	Caffeine can decrease insulin sensitivity in humans.	Caffeine	0-8	insulin	Homo sapiens	22-29
11815511-4	2002	We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake.	Caffeine	21-29	insulin	Homo sapiens	38-45
11815511-10	2002	RESULTS: Caffeine decreased insulin sensitivity by 15% (P &lt; 0.05 vs. placebo).	Caffeine	9-17	insulin	Homo sapiens	28-35
11815511-14	2002	CONCLUSIONS: Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels.	Caffeine	13-21	insulin	Homo sapiens	35-42
11815519-0	2002	Caffeine: a cause of insulin resistance?	Caffeine	0-8	insulin	Homo sapiens	21-28
11826159-6	2002	The caffeine-induced Ca2+ responses were inhibited by intracellular application of an anti-RYR3-specific antibody.	Caffeine	4-12	ryanodine receptor 3	Mus musculus	91-95
11816027-6	2002	Loss of MSL1 and NST1 function has pleiotropic phenotypes including increased sensitivity to divalent cations (manganese and zinc) and to caffeine (a cell wall-weakening agent).	Caffeine	138-146	U2 snRNP complex subunit MSL1	Saccharomyces cerevisiae S288C	8-12
11835680-0	2002	Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner.	Caffeine	0-8	tumor protein p53	Homo sapiens	17-21
11835680-3	2002	Surprisingly, at a concentration of 5 mM, caffeine not only induced apoptosis by itself and acted synergistically to enhance radiation-induced apoptosis, but also induced a TP53-independent G(1)-phase arrest.	Caffeine	42-50	tumor protein p53	Homo sapiens	173-177
11835680-5	2002	CDK2 activity was suppressed by caffeine, whereas activity of CDC2 was enhanced by suppressing phosphorylation on Tyr15 and by interfering with 14-3-3 binding to CDC25C.	Caffeine	32-40	cyclin dependent kinase 2	Homo sapiens	0-4
11816027-6	2002	Loss of MSL1 and NST1 function has pleiotropic phenotypes including increased sensitivity to divalent cations (manganese and zinc) and to caffeine (a cell wall-weakening agent).	Caffeine	138-146	Nst1p	Saccharomyces cerevisiae S288C	17-21
11682234-5	2002	Using this procedure, caffeine metabolic ratios were determined in 20 subjects with characteristic CYP1A2 activities, relatively to smoking habit and contraceptives intake.	Caffeine	22-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	99-105
11682466-4	2002	Other RyR agonists, which activate the RyR without mediation of the DHP receptor (e.g. caffeine, polylysine, and peptide A), induced Ca(2+) release without producing such an MCA fluorescence increase.	Caffeine	87-95	ryanodine receptor 1	Homo sapiens	6-9
12509296-10	2002	Since HPV16 (E6/E7) transformed XPV cells were highly UV sensitive and not further sensitized by caffeine, it appears likely that caffeine sensitization proceeds through a p53 pathway.	Caffeine	130-138	protein E6*;transforming protein E6	Human papillomavirus type 16	13-18
12509296-10	2002	Since HPV16 (E6/E7) transformed XPV cells were highly UV sensitive and not further sensitized by caffeine, it appears likely that caffeine sensitization proceeds through a p53 pathway.	Caffeine	130-138	tumor protein p53	Homo sapiens	172-175
12398802-5	2002	Conversely, treating aged oocytes with caffeine reduced p34(cdc2) phosphorylation and increased MPF activity.	Caffeine	39-47	cyclin dependent kinase 1	Sus scrofa	60-64
11673462-5	2001	Our results show that (i) Epstein-Barr virus-immortalized B-cells from MH-susceptible individuals carrying the V2168M RYR1 gene mutation were more sensitive to the RYR activator 4-chloro-m-cresol and (ii) their peripheral blood leukocytes produce more interleukin (IL)-1beta after treatment with the RYR activators caffeine and 4-chloro-m-cresol, compared with cells from healthy controls.	Caffeine	315-323	ryanodine receptor 1	Homo sapiens	118-122
12392153-1	2002	In an earlier study, we showed that oral administration of green tea or caffeine to SKH-1 mice for 2 weeks prior to a single application of UVB enhanced UVB-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis.	Caffeine	72-80	transformation related protein 53, pseudogene	Mus musculus	192-195
12392153-1	2002	In an earlier study, we showed that oral administration of green tea or caffeine to SKH-1 mice for 2 weeks prior to a single application of UVB enhanced UVB-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis.	Caffeine	72-80	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	212-215
12392153-1	2002	In an earlier study, we showed that oral administration of green tea or caffeine to SKH-1 mice for 2 weeks prior to a single application of UVB enhanced UVB-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis.	Caffeine	72-80	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	216-225
12392153-2	2002	In the present study, we found that topical application of caffeine, a major chemopreventive agent in tea, to the dorsal skin of SKH-1 mice immediately after irradiation with UVB (30 mJ/cm2) enhanced UVB-induced apoptosis as measured by the number of morphologically distinct epidermal apoptotic sunburn cells and the number of caspase 3-positive cells.	Caffeine	59-67	caspase 3	Mus musculus	328-337
12392153-4	2002	Topical application of caffeine immediately after UVB enhanced UVB-induced increases in caspase 3 (active form)-immunoreactive-positive cells and in caspase 3 enzyme activity in the epidermis.	Caffeine	23-31	caspase 3	Mus musculus	88-97
12392153-4	2002	Topical application of caffeine immediately after UVB enhanced UVB-induced increases in caspase 3 (active form)-immunoreactive-positive cells and in caspase 3 enzyme activity in the epidermis.	Caffeine	23-31	caspase 3	Mus musculus	149-158
12392153-5	2002	Topical application of caffeine had only a small stimulatory effect on UVB-induced increases in the level of wild-type p53 protein and these changes were not related temporally to caffeine-induced increases in apoptotic cells.	Caffeine	23-31	transformation related protein 53, pseudogene	Mus musculus	119-122
12164316-6	2002	Caffeine, an agonist for RyR fails to release Ca2+ and indeed produces relaxation not contraction.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	25-28
12497002-1	2002	The caffeine test measures the activity of cytochrome p450 (CYP1A2) which is a major enzyme involved in the activation of flutamide.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
11741482-1	2001	Caffeine (CAF), a methyl-substituted xanthine, interacts with polyaromatic DNA intercalators and has been hypothesized to interfere with their intercalation into DNA.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	10-13
11731442-5	2001	Caffeine, an inhibitor of ATM and ATM-Rad3 related (ATR) but not DNA-PK, generates an ataxia-telangiectasia-like response in wild-type cells, prevents completely RPA2 phosphorylation in DNA-PKcs deficient cells, but has no effect on ataxia-telangiectasia cells.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	26-29
11720987-2	2001	Expression of RyR3 restored caffeine-sensitive, global Ca(2+) release and causes the appearance of relatively frequent, spontaneous, spatially localized elevations of [Ca(2+)], as well as occasional spontaneous, propagating Ca(2+) release, in both intact and saponin-permeabilized myotubes.	Caffeine	28-36	ryanodine receptor 3	Homo sapiens	14-18
11720987-4	2001	Expression of RyR1 restored depolarization-induced global Ca(2+) release in intact myotubes and caffeine-induced global release in both intact and permeabilized myotubes.	Caffeine	96-104	ryanodine receptor 1	Homo sapiens	14-18
11731442-5	2001	Caffeine, an inhibitor of ATM and ATM-Rad3 related (ATR) but not DNA-PK, generates an ataxia-telangiectasia-like response in wild-type cells, prevents completely RPA2 phosphorylation in DNA-PKcs deficient cells, but has no effect on ataxia-telangiectasia cells.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	34-50
11731442-5	2001	Caffeine, an inhibitor of ATM and ATM-Rad3 related (ATR) but not DNA-PK, generates an ataxia-telangiectasia-like response in wild-type cells, prevents completely RPA2 phosphorylation in DNA-PKcs deficient cells, but has no effect on ataxia-telangiectasia cells.	Caffeine	0-8	ATR serine/threonine kinase	Homo sapiens	52-55
11731442-5	2001	Caffeine, an inhibitor of ATM and ATM-Rad3 related (ATR) but not DNA-PK, generates an ataxia-telangiectasia-like response in wild-type cells, prevents completely RPA2 phosphorylation in DNA-PKcs deficient cells, but has no effect on ataxia-telangiectasia cells.	Caffeine	0-8	replication protein A2	Homo sapiens	162-166
11760011-2	2001	Other treatments that induce c-fos expression in the fetal SCN include caffeine and nicotine.	Caffeine	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-34
11755554-8	2001	Caffeine was a risk factor for spontaneous abortion among women with high, but not low, CYP1A2 activity (OR 2.42, 95% CI 1.01, 5.80 for 100-299 mg/day; OR 3.17, 95% CI 1.22, 8.22 for 300 mg/day or more, among women with high CYP1A2 activity).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	225-231
11755554-9	2001	CONCLUSION: The findings indicate that high CYP1A2 activity may increase the risk of spontaneous abortion, independently or by modifying the effect of caffeine.	Caffeine	151-159	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
11717163-10	2001	Ca(2+) sparks and STOCs in both RyR3-deficient and wild-type cells were inhibited by ryanodine (10 micromol/L), external Ca(2+) removal, and depletion of SR Ca(2+) stores by caffeine (1 mmol/L).	Caffeine	174-182	ryanodine receptor 3	Mus musculus	32-36
11761118-3	2001	This method of phenotype determination accurately reflected the rate constant for the cytochrome P4501A2 (CYP1A2)-catalysed 3-demethylation of caffeine in vivo.	Caffeine	143-151	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	86-104
11761118-3	2001	This method of phenotype determination accurately reflected the rate constant for the cytochrome P4501A2 (CYP1A2)-catalysed 3-demethylation of caffeine in vivo.	Caffeine	143-151	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	106-112
11684540-8	2001	Furthermore, women with the tt genetic variant of VDR appear to be at a greater risk for this deleterious effect of caffeine on bone.	Caffeine	116-124	vitamin D receptor	Homo sapiens	50-53
11695996-9	2001	Amino acids 2370-2375 lie within a sequence (amino acids 2163-2458) in which some eight RyR1 mutations have been associated with malignant hyperthermia and shown to be hypersensitive to caffeine and 4-chloro-m-cresol activation.	Caffeine	186-194	ryanodine receptor 1	Oryctolagus cuniculus	88-92
11695996-11	2001	Thus amino acids 2163-2458 form a regulatory domain (malignant hyperthermia regulatory domain 2) that regulates caffeine and 4-chloro-m-cresol sensitivity of RyR1.	Caffeine	112-120	ryanodine receptor 1	Oryctolagus cuniculus	158-162
11514540-4	2001	We show that inhibition of Plk1 kinase activity is efficiently blocked by the radio-sensitizing agent caffeine.	Caffeine	102-110	polo like kinase 1	Homo sapiens	27-31
11574941-0	2001	Acute and chronic caffeine administration differentially alters striatal gene expression in wild-type and adenosine A(2A) receptor-deficient mice.	Caffeine	18-26	adenosine A2a receptor	Mus musculus	106-130
11734996-9	2001	In summary, elevated cyclin A levels are important for the capacity of cells to be driven into mitosis by caffeine addition, for the ability of cells to progress to mitosis with detached kinetochores, and for centrosome/spindle pole replication.	Caffeine	106-114	cyclin A2	Homo sapiens	21-29
11745415-2	2001	This process was supposed to involve the tumor suppressor gene p53 as it was described that p53 negative cells were more sensitive to checkpoint inhibition by caffeine than the wildtype phenotype.	Caffeine	159-167	tumor protein p53	Homo sapiens	63-66
11745415-2	2001	This process was supposed to involve the tumor suppressor gene p53 as it was described that p53 negative cells were more sensitive to checkpoint inhibition by caffeine than the wildtype phenotype.	Caffeine	159-167	tumor protein p53	Homo sapiens	92-95
11745415-11	2001	In addition, caffeine restored a G1 delay after irradiation in the cell lines with abrogated p53 functions.	Caffeine	13-21	tumor protein p53	Homo sapiens	93-96
11600135-8	2001	Cigarette smoking, use of aspirin and/or NSAIDs, use of vitamin/mineral supplements, and consumption of caffeine were associated with both Ki-ras+ and Ki-ras- tumors; the associations were not confounded by dietary intake or other lifestyle factors.	Caffeine	104-112	KRAS proto-oncogene, GTPase	Homo sapiens	139-145
11600135-8	2001	Cigarette smoking, use of aspirin and/or NSAIDs, use of vitamin/mineral supplements, and consumption of caffeine were associated with both Ki-ras+ and Ki-ras- tumors; the associations were not confounded by dietary intake or other lifestyle factors.	Caffeine	104-112	KRAS proto-oncogene, GTPase	Homo sapiens	151-157
11684540-0	2001	Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes.	Caffeine	0-8	vitamin D receptor	Homo sapiens	84-102
11860456-7	2001	Between E12 and E13, there is a striking transition in the pattern of calcium release elicited by specific agonists of these channels, thimerosal for IP3R and caffeine for RyR.	Caffeine	159-167	ryanodine receptor 1, skeletal muscle	Mus musculus	172-175
11887335-7	2001	Plasma component levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol and glucose were higher than the control in the males and females treated with 0.05% of caffeine.	Caffeine	193-201	glutamic pyruvic transaminase, soluble	Mus musculus	27-51
11887335-7	2001	Plasma component levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol and glucose were higher than the control in the males and females treated with 0.05% of caffeine.	Caffeine	193-201	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	59-85
11887335-7	2001	Plasma component levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol and glucose were higher than the control in the males and females treated with 0.05% of caffeine.	Caffeine	193-201	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	87-90
11985335-1	2001	The primary metabolic pathways of caffeine are 3-N-demethylation to paraxanthine (CYP1A2), 1-N-demethylation to theobromine and 7-N-demethylation to theophylline (CYP1A2 and other enzymes), and 8-hydroxylation to 1,3,7-trimethyluric acid (CYP3A).	Caffeine	34-42	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	82-88
11985335-1	2001	The primary metabolic pathways of caffeine are 3-N-demethylation to paraxanthine (CYP1A2), 1-N-demethylation to theobromine and 7-N-demethylation to theophylline (CYP1A2 and other enzymes), and 8-hydroxylation to 1,3,7-trimethyluric acid (CYP3A).	Caffeine	34-42	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	163-169
11985335-1	2001	The primary metabolic pathways of caffeine are 3-N-demethylation to paraxanthine (CYP1A2), 1-N-demethylation to theobromine and 7-N-demethylation to theophylline (CYP1A2 and other enzymes), and 8-hydroxylation to 1,3,7-trimethyluric acid (CYP3A).	Caffeine	34-42	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	239-244
11574941-5	2001	Chronic caffeine and DPCPX-mediated regulation in neuropeptide and GADs striatal gene expression typically showed the mimicking of alterations resulting from the A(2A)-R genetic deficiency in 25 mg/kg caffeine-treated wild-type mice as well as the dose-dependent normalization of substance P and enkephalin expression in A(2A)-R(-/-) mice.	Caffeine	8-16	GRB2-related adaptor protein 2	Mus musculus	67-71
11574941-5	2001	Chronic caffeine and DPCPX-mediated regulation in neuropeptide and GADs striatal gene expression typically showed the mimicking of alterations resulting from the A(2A)-R genetic deficiency in 25 mg/kg caffeine-treated wild-type mice as well as the dose-dependent normalization of substance P and enkephalin expression in A(2A)-R(-/-) mice.	Caffeine	8-16	tachykinin 1	Mus musculus	280-291
11574941-5	2001	Chronic caffeine and DPCPX-mediated regulation in neuropeptide and GADs striatal gene expression typically showed the mimicking of alterations resulting from the A(2A)-R genetic deficiency in 25 mg/kg caffeine-treated wild-type mice as well as the dose-dependent normalization of substance P and enkephalin expression in A(2A)-R(-/-) mice.	Caffeine	201-209	GRB2-related adaptor protein 2	Mus musculus	67-71
11507100-5	2001	Single-channel studies revealed that the ryanodine-modified wt RyR2 channel was sensitive to inhibition by Mg(2+) and to activation by caffeine and ATP.	Caffeine	135-143	ryanodine receptor 2	Homo sapiens	63-67
11507087-6	2001	Translocation and activation of cPLA(2), as well as Ca(2+) accumulation in sarcoplasmic reticulum stores sensitive to caffeine and amplification of [Ca(2+)](i) cycling in response to beta(2)-AR agonists, were blocked by inhibitors of the p38 or p42/44 MAPK pathway (SB203580 and PD98059, respectively), suggesting a role of both MAPK subtypes in beta(2)-AR stimulation.	Caffeine	118-126	adapter molecule crk	Gallus gallus	238-241
11514551-4	2001	ATP-stimulated Pmr1-overexpressing cells responded after a latency to extracellular Ca(2+) with a regenerative Ca(2+) signal, which could be prevented by caffeine.	Caffeine	154-162	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	15-19
11507087-6	2001	Translocation and activation of cPLA(2), as well as Ca(2+) accumulation in sarcoplasmic reticulum stores sensitive to caffeine and amplification of [Ca(2+)](i) cycling in response to beta(2)-AR agonists, were blocked by inhibitors of the p38 or p42/44 MAPK pathway (SB203580 and PD98059, respectively), suggesting a role of both MAPK subtypes in beta(2)-AR stimulation.	Caffeine	118-126	glutamate-ammonia ligase	Gallus gallus	245-248
11597588-1	2001	The hypothesis that intracellular calcium ([Ca(2+)](i)) release in glomus cells via ryanodine receptor (RyR) activation by caffeine may be independent of natural stimuli and chemosensory discharge was tested in the rat carotid body (CB).	Caffeine	123-131	ryanodine receptor 2	Rattus norvegicus	104-107
11597588-7	2001	Additional treatment of the cells with 50 microM ryanodine (an inhibitor of the caffeine-activated RyR site) abolished caffeine-stimulated response.	Caffeine	80-88	ryanodine receptor 2	Rattus norvegicus	99-102
11597588-7	2001	Additional treatment of the cells with 50 microM ryanodine (an inhibitor of the caffeine-activated RyR site) abolished caffeine-stimulated response.	Caffeine	119-127	ryanodine receptor 2	Rattus norvegicus	99-102
11489880-0	2001	Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein.	Caffeine	0-8	tumor protein p53	Homo sapiens	44-47
11489880-0	2001	Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein.	Caffeine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	136-139
11489880-6	2001	In the setting of an overexpression of BAX, caffeine induced a conformational change of the protein and apoptosis.	Caffeine	44-52	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
11489880-8	2001	All together, caffeine synergizes with p53 for inducing cell death through a cell cycle-independent mechanism, involving mitochondrial translocation and conformational change of BAX protein.	Caffeine	14-22	tumor protein p53	Homo sapiens	39-42
11489880-8	2001	All together, caffeine synergizes with p53 for inducing cell death through a cell cycle-independent mechanism, involving mitochondrial translocation and conformational change of BAX protein.	Caffeine	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
11600671-6	2001	The waves were blocked by the ryanodine receptor (RyR)-specific agents ryanodine and tetracaine, and potentiated by caffeine.	Caffeine	116-124	ryanodine receptor 2	Homo sapiens	50-53
11871327-3	2001	When extracting the components of caffeine and saridon tablets, paracetamol, propifenasone, and caffeine should be extracted with ethylacetate at pH 2 and codeine by chloroform at pH 10.	Caffeine	96-104	polyhomeotic homolog 2	Homo sapiens	146-150
11600673-4	2001	CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked by caffeine, Sp-cAMPS or forskolin.	Caffeine	82-90	glucagon-like peptide 1 receptor	Rattus norvegicus	26-40
11568936-5	2001	The increase was also evident after caffeine addition, but in cells treated with substance P and substance P + caffeine we observed a [Ca(2+)](i) decrease after exposure.	Caffeine	36-44	tachykinin precursor 1	Homo sapiens	81-92
11568936-5	2001	The increase was also evident after caffeine addition, but in cells treated with substance P and substance P + caffeine we observed a [Ca(2+)](i) decrease after exposure.	Caffeine	36-44	tachykinin precursor 1	Homo sapiens	97-108
11568936-5	2001	The increase was also evident after caffeine addition, but in cells treated with substance P and substance P + caffeine we observed a [Ca(2+)](i) decrease after exposure.	Caffeine	111-119	tachykinin precursor 1	Homo sapiens	97-108
11568936-7	2001	In this case, after EMFs exposure of cells treated with substance P, the [Ca(2+)](i), measured without and with addition of caffeine, declined from 824 +/- 425 to 38 +/- 13 nM and from 1369 +/- 700 to 11 +/- 4 nM, respectively, indicating that electromagnetic fields act either on intracellular Ca(2+) stores or on the plasma membrane.	Caffeine	124-132	tachykinin precursor 1	Homo sapiens	56-67
11577027-6	2001	In comparison, sensitization of ryanodine receptors (RyRs) by caffeine, a true RyR agonist, caused a rapid (&lt;1 second) and transient potentiation of Ca(2+) sparks followed by a decrease in SR Ca(2+) content.	Caffeine	62-70	ryanodine receptor 2	Rattus norvegicus	53-56
11574419-1	2001	The purpose of this investigation was to examine the effect of caffeine (an adenosine receptor antagonist) on whole-body insulin-mediated glucose disposal in resting humans.	Caffeine	63-71	insulin	Homo sapiens	121-128
11697539-7	2001	CYP1A2 activity was significantly increased by pretreatment with caffeine solution.	Caffeine	65-73	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
11477079-5	2001	Depletion of the ryanodine-sensitive store, by repeated application of caffeine, in the presence of ryanodine, abolished the response to Ins(1,4,5)P(3), suggesting that Ins(1,4,5)P(3)R and RyR share a common Ca(2+) store.	Caffeine	71-79	ryanodine receptor 2	Homo sapiens	189-192
11568134-4	2001	Time to reach T(lim) increased by 17 +/- 5.25% (P &lt; 0.02) after caffeine administration compared with the placebo trial.	Caffeine	67-75	PDZ and LIM domain 5	Homo sapiens	16-19
11568134-9	2001	Based on these data, the caffeine-induced increase in T(lim) may have been caused by a willingness to maintain near-maximal activation longer because of alterations in muscle sensory processes.	Caffeine	25-33	PDZ and LIM domain 5	Homo sapiens	56-59
11677656-6	2001	In fact, caffeine inhibits ATM kinase activity at concentrations that result in an A-T-like phenotype with loss of cell cycle checkpoints and hypersensitivity to ionizing radiation.	Caffeine	9-17	ATM serine/threonine kinase	Homo sapiens	27-30
11677656-8	2001	Interestingly, caffeine and other methyl xanthines preferentially radiosensitize cells that lack normal p53 function.	Caffeine	15-23	tumor protein p53	Homo sapiens	104-107
11447225-3	2001	Induction of phosphorylation of p53 on multiple serine residues by H(2)O(2) was caffeine-sensitive and blocked in ATM(-/-) cells.	Caffeine	80-88	tumor protein p53	Homo sapiens	32-35
11535615-3	2001	We show that both Chk1 and Chk2 are phosphorylated and activated in a caffeine-sensitive signaling pathway during S phase, but only in response to replication blocks, not during normal S phase progression.	Caffeine	70-78	checkpoint kinase 1	Homo sapiens	18-22
11535615-3	2001	We show that both Chk1 and Chk2 are phosphorylated and activated in a caffeine-sensitive signaling pathway during S phase, but only in response to replication blocks, not during normal S phase progression.	Caffeine	70-78	checkpoint kinase 2	Homo sapiens	27-31
11603126-4	2001	All  subjects were phenotyped for NAT2 by the molar ratio of two caffeine metabolites in the urine which was  determined by the high performance liquid chromatography (HPLC) method.	Caffeine	65-73	N-acetyltransferase 2	Homo sapiens	34-38
11502581-7	2001	Forskolin or PLB-KO increased SR Ca(2+) load, as measured by caffeine-induced Ca(2+) transients.	Caffeine	61-69	phospholamban	Mus musculus	13-16
11502601-7	2001	Caffeine (2 mM) greatly reduces the p53 level and Ser(15) phosphorylation, followed by a remarkable increase of DNA replication rate, by failure of hypertonicity to inhibit it, and by reduction of cell number during hypertonicity.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	36-39
11427530-2	2001	All mutants except I4829A and I4829T (corresponding to the I4897T central core disease mutant in RyR1) displayed caffeine-induced Ca(2+) release in HEK-293 cells; only mutants G4826A, I4829V, and G4830A retained high affinity [(3)H]ryanodine binding; and single-channel function was found for all mutants tested, except for G4822A and A4825V.	Caffeine	113-121	ryanodine receptor 1	Homo sapiens	97-101
11558565-3	2001	In this study, we examined the application of the PKCYP-test to the clearance of acetanilide and caffeine mediated by CYP1A2 using rat models in which the levels of CYP enzymes were reduced.	Caffeine	97-105	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	118-124
11558565-3	2001	In this study, we examined the application of the PKCYP-test to the clearance of acetanilide and caffeine mediated by CYP1A2 using rat models in which the levels of CYP enzymes were reduced.	Caffeine	97-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	52-55
11558565-5	2001	In both rat models, the contribution (fCYP) of CYP1A2 to the in vivo intrinsic clearance values (CLint) of acetanilide and caffeine metabolism was less than unity, suggesting that other metabolic pathways are involved in the CLint.	Caffeine	123-131	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	47-53
11558565-8	2001	The clearance of caffeine mediated by CYP1A2 in CD-fed and aged rats, as estimated from the predicted level of CYP1A2, correlated with the observed values.	Caffeine	17-25	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	38-44
11558565-8	2001	The clearance of caffeine mediated by CYP1A2 in CD-fed and aged rats, as estimated from the predicted level of CYP1A2, correlated with the observed values.	Caffeine	17-25	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	111-117
11532863-6	2001	Following a 12 day period of cruciferous vegetable consumption (period 2), induction of hepatic CYP1A2 activity was apparent from changes in the kinetics of caffeine metabolism.	Caffeine	157-165	period circadian regulator 2	Homo sapiens	64-72
11532863-6	2001	Following a 12 day period of cruciferous vegetable consumption (period 2), induction of hepatic CYP1A2 activity was apparent from changes in the kinetics of caffeine metabolism.	Caffeine	157-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	96-102
11507241-5	2001	As caffeine is an inhibitor of ATM kinase, these results suggest the existence of some redundant ATM-independent checkpoint in G(2) of ataxia telangiectasia cells.	Caffeine	3-11	ATM serine/threonine kinase	Homo sapiens	31-34
11507241-5	2001	As caffeine is an inhibitor of ATM kinase, these results suggest the existence of some redundant ATM-independent checkpoint in G(2) of ataxia telangiectasia cells.	Caffeine	3-11	ATM serine/threonine kinase	Homo sapiens	97-100
11427530-10	2001	Analysis of Gly(4822) to Asp(4831) mutants in RyR2 supports the view that this highly conserved sequence constitutes part of the ion-conducting pore of the Ca(2+) release channel and plays a key role in ryanodine and caffeine binding and activation.	Caffeine	217-225	ryanodine receptor 2	Homo sapiens	46-50
11599655-3	2001	CYP1A2-specific activity was also measured by phenacetin O-deethylation and caffeine 3-demethylation.	Caffeine	76-84	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
11509335-9	2001	IL-4 (50 ng/ml) also inhibited responses to caffeine (S2/S1: 0.30 +/- 0.04 and 0.54 +/- 0.06 for IL-4-treated versus control).	Caffeine	44-52	interleukin 4	Bos taurus	0-4
11509335-9	2001	IL-4 (50 ng/ml) also inhibited responses to caffeine (S2/S1: 0.30 +/- 0.04 and 0.54 +/- 0.06 for IL-4-treated versus control).	Caffeine	44-52	interleukin 4	Bos taurus	97-101
11509335-11	2001	Because caffeine-stimulated transients were inhibited, IL-4 may act, at least in part, by depleting calcium stores.	Caffeine	8-16	interleukin 4	Bos taurus	55-59
11443058-3	2001	This suggests a direct relation between response to caffeine and RyR3 expression.	Caffeine	52-60	ryanodine receptor 3	Mus musculus	65-69
11443058-4	2001	The lack of RyR3 reduced caffeine response in young, but not in adult mice, and did not abolish the age-dependent variation and the intermuscle differences.	Caffeine	25-33	ryanodine receptor 3	Mus musculus	12-16
11443058-5	2001	In diaphragm single fibers, the response to caffeine increased during development and was reduced in fibers lacking RyR3 both at 15 and 60 PND.	Caffeine	44-52	ryanodine receptor 3	Mus musculus	116-120
11443058-6	2001	A population of fibers highly responsive to caffeine was present in adult WT and disappeared in RyR3-/-.	Caffeine	44-52	ryanodine receptor 3	Mus musculus	96-100
11478588-0	2001	Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.	Caffeine	0-8	insulin	Homo sapiens	35-42
11476124-0	2001	CYP1A2 activity as measured by a caffeine test predicts clozapine and active metabolite steady-state concentrationin patients with schizophrenia.	Caffeine	33-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
11476124-6	2001	The in vivo CYP1A2 activity was measured using the caffeine metabolic ratio (CMR) in overnight urine.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
11476124-16	2001	CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity.	Caffeine	33-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
11476124-16	2001	CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity.	Caffeine	33-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	163-169
11477212-7	2001	Kinetic data from individual patients permit us to speculate that the interactions between caffeine and Glut1 are influenced by the mutation.	Caffeine	91-99	solute carrier family 2 member 1	Homo sapiens	104-109
11477212-8	2001	Three mM caffeine also inhibits the transport of dehydroascorbic acid (DHA), another substrate for Glut1.	Caffeine	9-17	solute carrier family 2 member 1	Homo sapiens	99-104
11477212-10	2001	These data indicate that caffeine and phenobarbital have similar Glut1 inhibitory properties in these two subjects.	Caffeine	25-33	solute carrier family 2 member 1	Homo sapiens	65-70
11481475-3	2001	Here, we have examined the possible involvement of the caffeine-sensitive ATM and ATR protein kinases in this checkpoint.	Caffeine	55-63	ATR serine/threonine kinase	Homo sapiens	82-85
11481475-4	2001	We show that caffeine"s ability to inhibit ATR (but not ATM) causes PCC, that ATR (but not ATM) prevents PCC, and that ATR prevents PCC via Chk-1 regulation.	Caffeine	13-21	ATR serine/threonine kinase	Homo sapiens	43-46
11481475-4	2001	We show that caffeine"s ability to inhibit ATR (but not ATM) causes PCC, that ATR (but not ATM) prevents PCC, and that ATR prevents PCC via Chk-1 regulation.	Caffeine	13-21	checkpoint kinase 1	Homo sapiens	140-145
11445277-5	2001	Caffeine increased all-out time in exercised rats, and inhibited the exercise-induced elevation in TPH expression.	Caffeine	0-8	tryptophan hydroxylase 1	Rattus norvegicus	99-102
11445277-6	2001	The suppressive effect of caffeine on TPH expression in exercised rats can be suggested as one possible ergogenic mechanism of caffeine.	Caffeine	26-34	tryptophan hydroxylase 1	Rattus norvegicus	38-41
11445277-6	2001	The suppressive effect of caffeine on TPH expression in exercised rats can be suggested as one possible ergogenic mechanism of caffeine.	Caffeine	127-135	tryptophan hydroxylase 1	Rattus norvegicus	38-41
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	188-196	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	188-196	ryanodine receptor 1	Homo sapiens	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	188-196	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	188-196	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	380-388	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	380-388	ryanodine receptor 1	Homo sapiens	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	380-388	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11396983-6	2001	No significant RyR1 fluorescence was observed at the plasma membrane.Fluo-4-loaded sf 21 cells expressing recombinant RyR1 responded to activating-low ryanodine concentrations (100 nM) or caffeine (10 mM) with a sharp rise in intracellular Ca2 followed by a sustained phase, in contrast, sf 21 cells expressing the human bradykinin type 2 receptor did not respond to ryanodine or caffeine.These results demonstrate the expression of recombinant RyR1 in sf 21 cells with functional properties similar to what has been previously reported for native RyR1 in mammalian tissues, however, some differences were observed in [3H]ryanodine binding assays compared to native rabbit RyR1.	Caffeine	380-388	ryanodine receptor 1	Oryctolagus cuniculus	118-122
11503005-6	2001	The hepatic enzyme activities were estimated by the urinary caffeine metabolic ratios as follows: CYP1A2 = (AAMU + 1X + 1U)/17U; XO = 1U/(1X + 1U); NAT2 = AAMU/(AAMU + 1X + 1U).	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
11461172-8	2001	Beta-adrenergic activity suppresses transcription of LPL in adipocytes; this phenomenon may contribute to the favorable impact of exercise training on visceral obesity; conceivably, preadministration of safe drugs that boost catecholamine activity (caffeine, yohimbine) could potentiate this beneficial effect of exercise.	Caffeine	249-257	lipoprotein lipase	Homo sapiens	53-56
11470917-1	2001	Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated.	Caffeine	0-8	adenosine A1 receptor	Mus musculus	76-81
11445277-0	2001	Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats.	Caffeine	0-8	tryptophan hydroxylase 1	Rattus norvegicus	47-69
11445277-1	2001	Effect of caffeine on the expression of tryptophan hydroxylase (TPH), rate limiting enzyme of serotonin synthesis, in dorsal and median raphe was investigated via immunohistochemistry.	Caffeine	10-18	tryptophan hydroxylase 1	Rattus norvegicus	40-62
11445277-1	2001	Effect of caffeine on the expression of tryptophan hydroxylase (TPH), rate limiting enzyme of serotonin synthesis, in dorsal and median raphe was investigated via immunohistochemistry.	Caffeine	10-18	tryptophan hydroxylase 1	Rattus norvegicus	64-67
11453726-2	2001	Recent kinetic and mass spectral data demonstrated that a difference in mechanism of inactivation exists for AChE treated with (1R)- versus (1S,3S)-stereoisomers.	Caffeine	140-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	109-113
11453726-13	2001	Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase.	Caffeine	121-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104
11453726-13	2001	Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase.	Caffeine	121-127	butyrylcholinesterase	Homo sapiens	154-175
11453726-13	2001	Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase.	Caffeine	121-127	carboxyl ester lipase	Homo sapiens	180-200
11478588-1	2001	We tested the hypothesis that caffeine ingestion results in an exaggerated response in blood glucose and (or) insulin during an oral glucose tolerance test (OGTT).	Caffeine	30-38	insulin	Homo sapiens	110-117
11478588-8	2001	In the caffeine trial the serum insulin and C peptide concentrations were significantly greater (P &lt; or = 0.001) than for placebo for the last 90 min of the OGTT and the area under the curve (AUC) for both measures were 60 and 37% greater (P &lt; or = 0.001), respectively.	Caffeine	7-15	insulin	Homo sapiens	32-39
11478588-9	2001	This prolonged, increased elevation in insulin did not result in a lower blood glucose level; in fact, the AUC for blood glucose was 24% greater (P = 0.20) in the caffeine treatment group.	Caffeine	163-171	insulin	Homo sapiens	39-46
11478588-10	2001	The data support our hypothesis that caffeine ingestion results in a greater increase in insulin concentration during an OGTT.	Caffeine	37-45	insulin	Homo sapiens	89-96
11478588-11	2001	This, together with a trend towards a greater rather than a more modest response in blood glucose, suggests that caffeine ingestion may have resulted in insulin resistance.	Caffeine	113-121	insulin	Homo sapiens	153-160
11990081-0	2001	Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes.	Caffeine	80-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-67
11452239-3	2001	METHODS: Twenty-five milligrams of melatonin was given at 9:30 am to 12 healthy Swedish volunteers, who had previously been phenotyped for CYP1A2 with caffeine.	Caffeine	151-159	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	139-145
11470995-0	2001	Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2.	Caffeine	7-15	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
11990081-1	2001	Caffeine is a marker drug for testing the activity of CYP1A2 (3-N-demethylation) in humans and rats.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	54-60
11990081-3	2001	In the case of 1-N- and in particular 7-N-demethylation of caffeine, apart from CYP1A2, other cytochrome P-450 isoenzymes play a considerable role.	Caffeine	59-67	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-86
11990081-3	2001	In the case of 1-N- and in particular 7-N-demethylation of caffeine, apart from CYP1A2, other cytochrome P-450 isoenzymes play a considerable role.	Caffeine	59-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-110
11990081-4	2001	The aim of the present study was to investigate the influence of imipramine, amitriptyline and fluoxetine on cytochrome P-450 activity measured by caffeine oxidation in rat liver microsomes.	Caffeine	147-155	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	109-125
11990081-8	2001	The influence of amitriptyline on 8-hydroxylation and especially on 7-N-demethylation of caffeine was weaker (Ki = 108 and 190 pM, respectively) than on 3-N- or 1-N-demethylation, suggesting a narrower spectrum of cytochrome P-450 inhibition by amitriptyline than by imipramine, involving mainly the subfamily CYP1A2, and--to a lesser degree--CYP3A.	Caffeine	89-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	214-230
11990081-8	2001	The influence of amitriptyline on 8-hydroxylation and especially on 7-N-demethylation of caffeine was weaker (Ki = 108 and 190 pM, respectively) than on 3-N- or 1-N-demethylation, suggesting a narrower spectrum of cytochrome P-450 inhibition by amitriptyline than by imipramine, involving mainly the subfamily CYP1A2, and--to a lesser degree--CYP3A.	Caffeine	89-97	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	310-316
11990081-8	2001	The influence of amitriptyline on 8-hydroxylation and especially on 7-N-demethylation of caffeine was weaker (Ki = 108 and 190 pM, respectively) than on 3-N- or 1-N-demethylation, suggesting a narrower spectrum of cytochrome P-450 inhibition by amitriptyline than by imipramine, involving mainly the subfamily CYP1A2, and--to a lesser degree--CYP3A.	Caffeine	89-97	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	343-348
11990081-10	2001	However, fluoxetine displayed a clear inhibitory effect on caffeine 7-N-demethylation (Ki = 72 microM), the reaction which is catalyzed mainly by other than CYP1A2 isoenzymes.	Caffeine	59-67	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	157-163
21047472-2	2001	METHODS: The enhancing effect of combination of caffeine and phenobarbital on the cytotoxicity of DDP on SPC-A-1 was detected by MTT assay.	Caffeine	48-56	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	105-112
21047472-1	2001	BACKGROUND: To investigate the enhancing effect of caffeine(CAF) on the anticancer activity of cisplatin on human lung cancer SPC-A-1 cells in vitro and study whether this enhancing effect of caffeine could be inhibited by phenobarbital(PBT).	Caffeine	51-59	lysine acetyltransferase 2B	Homo sapiens	60-63
11459180-5	2001	Furthermore, pim1 mutants are hypersensitive to caffeine and cell wall-destabilising compounds.	Caffeine	48-56	ATP-dependent Lon protease PIM1	Saccharomyces cerevisiae S288C	13-17
21047472-1	2001	BACKGROUND: To investigate the enhancing effect of caffeine(CAF) on the anticancer activity of cisplatin on human lung cancer SPC-A-1 cells in vitro and study whether this enhancing effect of caffeine could be inhibited by phenobarbital(PBT).	Caffeine	51-59	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	126-133
11459203-4	2001	This hypothesis was tested with respect to CYP1A2, by using the clearance of caffeine by N-demethylation as a phenotypic trait measurement of the isoform"s catalytic activity.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
11346485-3	2001	Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence, multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone.	Caffeine	122-130	nuclear RNA export factor 1	Rattus norvegicus	101-104
11346485-3	2001	Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence, multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone.	Caffeine	122-130	nuclear RNA export factor 1	Rattus norvegicus	357-360
11459180-6	2001	Pim1 is phosphorylated at two sites, and thereby activated, in response to heat stress, caffeine and agents that alter the fungal cell wall, which is consistent with a role in adaptation to these conditions.	Caffeine	88-96	ATP-dependent Lon protease PIM1	Saccharomyces cerevisiae S288C	0-4
11484776-1	2001	The release of Ca2+ in response to caffeine at threshold concentration (5 mM) was studied in mouse skeletal myotubes.	Caffeine	35-43	carbonic anhydrase 2	Mus musculus	15-18
11484776-2	2001	Repeated 5-s applications of caffeine, each followed by a 30-s washout, caused Ca2+ releases of consecutively growing amplitude (staircase phenomenon).	Caffeine	29-37	carbonic anhydrase 2	Mus musculus	79-82
11484776-6	2001	When threshold caffeine was applied continuously for up to 10 min, the increase in Ca2+ concentration as seen with staircase potentiation did not occur.	Caffeine	15-23	carbonic anhydrase 2	Mus musculus	83-86
11484776-7	2001	Depolarization by elevated [K+] or by voltage-clamp steps potentiated caffeine-induced Ca2+ release rapidly as compared to the slow exponential growth of staircase-like potentiation.	Caffeine	70-78	carbonic anhydrase 2	Mus musculus	87-90
11484785-10	2001	The results are compatible with the assumption that inhibition of the Atm-dependent homologous recombination repair by caffeine, brings differential effects in LY sublines because of the defect of the alternative DNA repair system (NHEJ) in LY-S cells.	Caffeine	119-127	ataxia telangiectasia mutated	Mus musculus	70-73
11484776-11	2001	We suggest that staircase-like potentiation is conditioned by a caffeine-dependent Ca2+ influx across the plasma membrane.	Caffeine	64-72	carbonic anhydrase 2	Mus musculus	83-86
11393735-0	2001	Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.	Caffeine	108-116	N-acetyltransferase 2	Homo sapiens	133-154
11278490-8	2001	Caffeine or UCN-01 abolishes the extreme radioresistance with the strong G(2) arrest and at the same time reduces the phosphorylation of Cdc2 in A1-5 cells.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	137-141
11278490-8	2001	Caffeine or UCN-01 abolishes the extreme radioresistance with the strong G(2) arrest and at the same time reduces the phosphorylation of Cdc2 in A1-5 cells.	Caffeine	0-8	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	145-149
11279043-8	2001	Caffeine, an inhibitor of the checkpoint kinases ATR and ATM, did not relieve the aphidicolin-induced block to origin firing.	Caffeine	0-8	ATR serine/threonine kinase L homeolog	Xenopus laevis	49-52
11353864-5	2001	Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+).	Caffeine	143-151	ryanodine receptor 3	Bos taurus	21-25
11353864-5	2001	Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+).	Caffeine	143-151	glutathione S-transferase kappa 1	Homo sapiens	30-33
11353864-5	2001	Purified recombinant RyR3 and GST-RyR3 proteins exhibited high-affinity [(3)H]ryanodine binding that was sensitive to activation by Ca(2+) and caffeine and to inhibition by Mg(2+).	Caffeine	143-151	ryanodine receptor 3	Bos taurus	34-38
11393735-0	2001	Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.	Caffeine	108-116	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-175
11393735-1	2001	Urinary metabolic ratios of caffeine are used in humans to assess the enzymatic activities of cytochrome P450 isoenzyme 1A2 (CYP1A2), xanthine oxidase (XO) and for phenotyping individuals for the bimodal N-acetyltransferase 2 (NAT2), all of them involved in the activation or detoxification of various xenobiotic compounds.	Caffeine	28-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	94-123
11393735-1	2001	Urinary metabolic ratios of caffeine are used in humans to assess the enzymatic activities of cytochrome P450 isoenzyme 1A2 (CYP1A2), xanthine oxidase (XO) and for phenotyping individuals for the bimodal N-acetyltransferase 2 (NAT2), all of them involved in the activation or detoxification of various xenobiotic compounds.	Caffeine	28-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131
11393735-1	2001	Urinary metabolic ratios of caffeine are used in humans to assess the enzymatic activities of cytochrome P450 isoenzyme 1A2 (CYP1A2), xanthine oxidase (XO) and for phenotyping individuals for the bimodal N-acetyltransferase 2 (NAT2), all of them involved in the activation or detoxification of various xenobiotic compounds.	Caffeine	28-36	N-acetyltransferase 2	Homo sapiens	204-225
11393735-1	2001	Urinary metabolic ratios of caffeine are used in humans to assess the enzymatic activities of cytochrome P450 isoenzyme 1A2 (CYP1A2), xanthine oxidase (XO) and for phenotyping individuals for the bimodal N-acetyltransferase 2 (NAT2), all of them involved in the activation or detoxification of various xenobiotic compounds.	Caffeine	28-36	N-acetyltransferase 2	Homo sapiens	227-231
11393735-6	2001	We report a liquid chromatographic method for the simultaneous quantitative analysis of the five urinary metabolites of caffeine used for the CYP1A2, XO and NAT2 phenotyping studies: AAMU, AFMU, 1-methylxanthine, 1-methyluric acid and 1,7-dimethyluric acid.	Caffeine	120-128	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
11393735-6	2001	We report a liquid chromatographic method for the simultaneous quantitative analysis of the five urinary metabolites of caffeine used for the CYP1A2, XO and NAT2 phenotyping studies: AAMU, AFMU, 1-methylxanthine, 1-methyluric acid and 1,7-dimethyluric acid.	Caffeine	120-128	N-acetyltransferase 2	Homo sapiens	157-161
11393735-12	2001	The procedure described here represents a substantial improvement over previous methods: a single analysis and a minimal urine sample treatment enables the simultaneous quantitation of five caffeine metabolites, notably AFMU and AAMU, used for the determination of CYP450 1A2, XO and NAT2 enzyme activity.	Caffeine	190-198	N-acetyltransferase 2	Homo sapiens	284-288
11369518-5	2001	FGF1 mobilizes Ins(1,4,5)P3-sensitive calcium stores, as recorded through the inhibition by caffeine of a chloride calcium-dependent current in expressing oocytes.	Caffeine	92-100	fibroblast growth factor 1 L homeolog	Xenopus laevis	0-4
11352859-5	2001	Regular smoking and caffeine consumption decrease CA125 levels (P &lt; 0.001).	Caffeine	20-28	mucin 16, cell surface associated	Homo sapiens	50-55
11382340-0	2001	Mechanism of protection against radiation-induced DNA damage in plasmid pBR322 by caffeine.	Caffeine	82-90	translocator protein	Homo sapiens	72-75
11302731-5	2001	On the other hand, treatment with wortmannin or caffeine suppressed CdCl(2)-induced Ser 15 phosphorylation and accumulation of p53 protein.	Caffeine	48-56	tumor protein p53	Homo sapiens	127-130
11340116-8	2001	In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration.	Caffeine	21-29	interleukin 1 beta	Rattus norvegicus	98-106
11340116-8	2001	In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration.	Caffeine	21-29	interleukin 6	Rattus norvegicus	108-112
11340116-8	2001	In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration.	Caffeine	21-29	interleukin 10	Rattus norvegicus	114-119
11340116-8	2001	In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration.	Caffeine	21-29	interferon gamma	Rattus norvegicus	124-133
11340116-8	2001	In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration.	Caffeine	21-29	tumor necrosis factor	Rattus norvegicus	162-171
11420069-8	2001	[3H]SCH 23390 (DA D(1)) binding sites were downregulated in the nucleus accumbens and striatum and were upregulated in the prefrontal cortex of caffeine-treated vs. control rats; however, the affinity of [3H]SCH 23390 for these binding sites was unaltered.	Caffeine	144-152	defender against cell death 1	Rattus norvegicus	15-22
11420069-10	2001	These results suggest that, although HAL did not alter the development of tolerance to caffeine, changes in DA D(1) receptors could be one component of the mechanism underlying caffeine-induced tolerance.	Caffeine	177-185	defender against cell death 1	Rattus norvegicus	108-115
11292476-1	2001	A competitive antigen ELISA was previously developed for NAT2 phenotyping, using caffeine as the probe drug.	Caffeine	81-89	N-acetyltransferase 2	Homo sapiens	57-61
11291094-10	2001	Results of Western hybridization reveal a p53-independent mechanism of radiosensitization caused by caffeine.	Caffeine	100-108	tumor protein p53	Homo sapiens	42-45
11150292-6	2001	In contrast, inhibition of RYR3 reduced the global Ca(2+) responses induced by caffeine and phenylephrine, indicating that RYR3 participated together with RYR1 and RYR2 to these Ca(2+) responses in Ca(2+)-overloaded myocytes.	Caffeine	79-87	ryanodine receptor 3	Rattus norvegicus	27-31
11150292-6	2001	In contrast, inhibition of RYR3 reduced the global Ca(2+) responses induced by caffeine and phenylephrine, indicating that RYR3 participated together with RYR1 and RYR2 to these Ca(2+) responses in Ca(2+)-overloaded myocytes.	Caffeine	79-87	ryanodine receptor 3	Rattus norvegicus	123-127
11150292-6	2001	In contrast, inhibition of RYR3 reduced the global Ca(2+) responses induced by caffeine and phenylephrine, indicating that RYR3 participated together with RYR1 and RYR2 to these Ca(2+) responses in Ca(2+)-overloaded myocytes.	Caffeine	79-87	ryanodine receptor 1	Rattus norvegicus	155-159
11150292-6	2001	In contrast, inhibition of RYR3 reduced the global Ca(2+) responses induced by caffeine and phenylephrine, indicating that RYR3 participated together with RYR1 and RYR2 to these Ca(2+) responses in Ca(2+)-overloaded myocytes.	Caffeine	79-87	ryanodine receptor 2	Rattus norvegicus	164-168
11150292-8	2001	Our results show that, under conditions of increased SR Ca(2+) loading, the RYR3 becomes activable by caffeine and local increases in [Ca(2+)](i).	Caffeine	102-110	ryanodine receptor 3	Rattus norvegicus	76-80
11246119-5	2001	Incubation of cytosolic fraction with xanthine oxidoreductase (XDh+XO) (XOR) cosubstrates (e.g. NAD+, hypoxanthine, xanthine, caffeine, theobromine, theophylline or 1,7-dimethylxanthine) significantly enhanced the biotransformation of ethanol to acetaldehyde.	Caffeine	126-134	xanthine dehydrogenase	Rattus norvegicus	63-66
11278197-3	2001	Using mRNA differential display, we observed that caffeine increased gene expression of the regulatory subunit (RI alpha) of cAMP-dependent protein kinase (PKA).	Caffeine	50-58	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	112-120
11278197-7	2001	Together these data suggest that in early post-implantation mouse embryos caffeine modulates gene expression of the RI alpha subunit of PKA and that caffeine-induced inhibition of PKA activity plays a role in early telencephalic evagination.	Caffeine	74-82	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	116-124
11264726-6	2001	The response was completely suppressed by thapsigargin, an inhibitior of endoplasmic reticulum Ca2+-ATPase, and was significantly suppressed by U-73122, an inhibitor of phospholipase C. The response was also suppressed by caffeine, a blocker of IP3 receptor, whereas that was not suppressed by ryanodine, an antagonist of ryanodine receptor.	Caffeine	222-230	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	245-257
11337548-9	2001	Both PTX and CAF dose dependently enhanced the cytotoxicity of 186Re-MAG3-A7: ERs of 0.5 mmol/L PTX, 2 mmol/L PTX, 1 mmol/L CAF, and 5 mmol/L CAF were 1.50, 2.18, 1.54, and 2.63, respectively.	Caffeine	13-16	paired like homeodomain 2	Homo sapiens	96-102
11337548-9	2001	Both PTX and CAF dose dependently enhanced the cytotoxicity of 186Re-MAG3-A7: ERs of 0.5 mmol/L PTX, 2 mmol/L PTX, 1 mmol/L CAF, and 5 mmol/L CAF were 1.50, 2.18, 1.54, and 2.63, respectively.	Caffeine	13-16	paired like homeodomain 1	Homo sapiens	110-116
11285205-4	2001	In this study, we examined the effect of CYP1A2 activity using a urinary caffeine metabolic ratio assay for 54 Chinese women with newly diagnosed lung cancer (including 28 adenocarcinomas) and 174 hospital controls.	Caffeine	73-81	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
11246119-5	2001	Incubation of cytosolic fraction with xanthine oxidoreductase (XDh+XO) (XOR) cosubstrates (e.g. NAD+, hypoxanthine, xanthine, caffeine, theobromine, theophylline or 1,7-dimethylxanthine) significantly enhanced the biotransformation of ethanol to acetaldehyde.	Caffeine	126-134	xanthine dehydrogenase	Rattus norvegicus	72-75
11281236-8	2001	Both caffeine (CAF) and ryanodine (RY) treatment attenuated Ang II-induced [Ca2+]i; however, pretreatment with ETI, IBU, or 7ER did not alter this effect.	Caffeine	5-13	angiotensinogen	Rattus norvegicus	60-66
11281236-8	2001	Both caffeine (CAF) and ryanodine (RY) treatment attenuated Ang II-induced [Ca2+]i; however, pretreatment with ETI, IBU, or 7ER did not alter this effect.	Caffeine	15-18	angiotensinogen	Rattus norvegicus	60-66
11162852-1	2001	Caffeine has been used as a pharmacological tool to study the ryanodine receptor (RYR)-mediated Ca2+ release from caffeine-sensitive, inositol 1,4,5,-trisphosphate (IP3)-insensitive pools.	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	62-80
11171121-11	2001	The observation that FKBP12 did not affect IP3-induced Ca2+ release but reduced caffeine-induced Ca2+ release also indicated that mature IP3R1 and IP3R3, in contrast to RyR1 and RyR3, did not display a specific, high-affinity interaction with FKBP12.	Caffeine	80-88	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	21-27
11330688-0	2001	Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice.	Caffeine	22-30	tumor necrosis factor	Mus musculus	69-96
11330688-1	2001	Tumor necrosis factor (TNF)-alpha-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug.	Caffeine	206-214	tumor necrosis factor	Mus musculus	0-33
11162852-1	2001	Caffeine has been used as a pharmacological tool to study the ryanodine receptor (RYR)-mediated Ca2+ release from caffeine-sensitive, inositol 1,4,5,-trisphosphate (IP3)-insensitive pools.	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	82-85
11162852-1	2001	Caffeine has been used as a pharmacological tool to study the ryanodine receptor (RYR)-mediated Ca2+ release from caffeine-sensitive, inositol 1,4,5,-trisphosphate (IP3)-insensitive pools.	Caffeine	114-122	ryanodine receptor 1	Homo sapiens	62-80
11162852-1	2001	Caffeine has been used as a pharmacological tool to study the ryanodine receptor (RYR)-mediated Ca2+ release from caffeine-sensitive, inositol 1,4,5,-trisphosphate (IP3)-insensitive pools.	Caffeine	114-122	ryanodine receptor 1	Homo sapiens	82-85
11162852-4	2001	Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (&gt; or = 25 mM) induced a Ca2+ influx.	Caffeine	9-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-57
11162852-4	2001	Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (&gt; or = 25 mM) induced a Ca2+ influx.	Caffeine	9-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
11162852-4	2001	Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (&gt; or = 25 mM) induced a Ca2+ influx.	Caffeine	9-17	ryanodine receptor 1	Homo sapiens	88-91
11162852-6	2001	Thus, caffeine may act as an inhibitor on a single or multiple site(s) responsible for regulating the IP3R channel, RYR channel and presumably the receptor-mediated SOC channel.	Caffeine	6-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
11162852-6	2001	Thus, caffeine may act as an inhibitor on a single or multiple site(s) responsible for regulating the IP3R channel, RYR channel and presumably the receptor-mediated SOC channel.	Caffeine	6-14	ryanodine receptor 1	Homo sapiens	116-119
11162852-8	2001	Our results suggest the need for caution regarding use of caffeine simply as a RYR-activator to study Ca2+ homeostasis in eucaryotic cells.	Caffeine	58-66	ryanodine receptor 1	Homo sapiens	79-82
11029464-4	2001	The peaks in [Ca(2+)] occurring in the mitochondrial matrix of mdx myotubes are significantly larger than in controls upon KCl-induced depolarization or caffeine application.	Caffeine	153-161	dystrophin, muscular dystrophy	Mus musculus	63-66
11222668-4	2001	DAT knock-out mice were also unresponsive to the normally robust wake-promoting action of modafinil, methamphetamine, and the selective DAT blocker GBR12909 but were hypersensitive to the wake-promoting effects of caffeine.	Caffeine	214-222	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	0-3
11360934-5	2001	In functional studies, caffeine decreased cytotoxicity against myocyte target cells which is probably related to an altered calcium signaling in CD8+ MLR lymphocytes.	Caffeine	23-31	CD8a molecule	Homo sapiens	145-148
11157671-9	2001	Caffeine-induced contractures were significantly larger in Ad-FKBP12.6-infected myocytes compared with Ad-GFP-infected control cells, indicating a higher SR-Ca(2+) load.	Caffeine	0-8	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	62-68
11270802-6	2001	RESULTS: Compared with results obtained in a group of 70 healthy subjects, caffeine metabolism before liver transplantation was deeply depressed with a decreased elimination rate in the case of all metabolites and a decreased CYP1A2 activity.	Caffeine	75-83	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	226-232
11360934-6	2001	Caffeine also terminated spontaneous Ca2+ oscillations and induced a rise in [Ca2+]i in CD4- and CD8- MLR lymphocytes probably of B cell origin.	Caffeine	0-8	CD4 molecule	Homo sapiens	88-91
11360934-0	2001	Functional importance and caffeine sensitivity of ryanodine receptors in primary lymphocytes.	Caffeine	26-34	ryanodine receptor 1	Homo sapiens	50-69
11360934-6	2001	Caffeine also terminated spontaneous Ca2+ oscillations and induced a rise in [Ca2+]i in CD4- and CD8- MLR lymphocytes probably of B cell origin.	Caffeine	0-8	CD8a molecule	Homo sapiens	97-100
11360934-4	2001	Furthermore, the increase of [Ca2+]i in CD4+ and CD8+ MLR T lymphocytes stimulated by 5 microg/ml concanavalin A was significantly inhibited by pretreatment with caffeine.	Caffeine	162-170	CD4 molecule	Homo sapiens	40-43
11360934-4	2001	Furthermore, the increase of [Ca2+]i in CD4+ and CD8+ MLR T lymphocytes stimulated by 5 microg/ml concanavalin A was significantly inhibited by pretreatment with caffeine.	Caffeine	162-170	CD8a molecule	Homo sapiens	49-52
11360934-7	2001	These results demonstrate that caffeine alters Ca2+ signaling in primary lymphocytes, and suggest that RyR, probably the skeletal muscle receptor (RyR-1) and brain receptor (RyR-3), are involved in mediating this effect.	Caffeine	31-39	ryanodine receptor 1	Homo sapiens	103-106
11360934-7	2001	These results demonstrate that caffeine alters Ca2+ signaling in primary lymphocytes, and suggest that RyR, probably the skeletal muscle receptor (RyR-1) and brain receptor (RyR-3), are involved in mediating this effect.	Caffeine	31-39	ryanodine receptor 1	Homo sapiens	147-150
11360934-7	2001	These results demonstrate that caffeine alters Ca2+ signaling in primary lymphocytes, and suggest that RyR, probably the skeletal muscle receptor (RyR-1) and brain receptor (RyR-3), are involved in mediating this effect.	Caffeine	31-39	ryanodine receptor 3	Homo sapiens	174-179
11772120-7	2001	Caffeine is an adenosine A(2A) receptor antagonist that enhances locomotor activity in animal models of parkinsonism.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	15-39
11050087-9	2001	Like the radiation-induced checkpoint, caffeine blocks p84N5-induced G(2)/M arrest but not subsequent apoptotic cell death.	Caffeine	39-47	THO complex 1	Homo sapiens	55-60
11050087-11	2001	We conclude that p84N5 induces an ataxia telangiectasia-mutated kinase (ATM)-independent, caffeine-sensitive G(2)/M cell cycle arrest prior to the onset of apoptosis.	Caffeine	90-98	THO complex 1	Homo sapiens	17-22
11050087-11	2001	We conclude that p84N5 induces an ataxia telangiectasia-mutated kinase (ATM)-independent, caffeine-sensitive G(2)/M cell cycle arrest prior to the onset of apoptosis.	Caffeine	90-98	ATM serine/threonine kinase	Homo sapiens	72-75
11169754-5	2001	Expression of PZL-1 in S. cerevisiae from the PPZ1 promoter was able to rescue the altered sensitivity to caffeine and lithium ions of a ppz1 strain.	Caffeine	106-114	salt homeostasis regulator	Saccharomyces cerevisiae S288C	46-50
11169754-5	2001	Expression of PZL-1 in S. cerevisiae from the PPZ1 promoter was able to rescue the altered sensitivity to caffeine and lithium ions of a ppz1 strain.	Caffeine	106-114	salt homeostasis regulator	Saccharomyces cerevisiae S288C	137-141
11121373-3	2001	In PASMC, depletion of sarcoplasmic reticulum Ca(2+) stores with Ryn (300 microM) and caffeine (Caf; 10 mM) eliminated subsequent Caf-induced intracellular Ca(2+) transients but had little or no effect on the initial IP(3)-mediated intracellular Ca(2+) transient induced by ANG II (1 microM).	Caffeine	86-94	ANG	Canis lupus familiaris	274-277
11121373-3	2001	In PASMC, depletion of sarcoplasmic reticulum Ca(2+) stores with Ryn (300 microM) and caffeine (Caf; 10 mM) eliminated subsequent Caf-induced intracellular Ca(2+) transients but had little or no effect on the initial IP(3)-mediated intracellular Ca(2+) transient induced by ANG II (1 microM).	Caffeine	96-99	ANG	Canis lupus familiaris	274-277
11121373-3	2001	In PASMC, depletion of sarcoplasmic reticulum Ca(2+) stores with Ryn (300 microM) and caffeine (Caf; 10 mM) eliminated subsequent Caf-induced intracellular Ca(2+) transients but had little or no effect on the initial IP(3)-mediated intracellular Ca(2+) transient induced by ANG II (1 microM).	Caffeine	130-133	ANG	Canis lupus familiaris	274-277
11772146-3	2001	In vitro and in vivo pharmacological research has provided some evidence that caffeine can have anti-nociceptive actions through blockade of adenosine receptors, inhibition of cyclo-oxygenase-2 enzyme synthesis, or by changes in emotion state.	Caffeine	78-86	prostaglandin-endoperoxide synthase 2	Homo sapiens	176-193
11204934-7	2001	RESULTS: Compared to healthy subjects, patients with PBC presented a reduced metabolism of caffeine due to a decreased CYP1A2 activity, all the more important since the patients had an advanced histological stage.	Caffeine	91-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
11120603-6	2001	In both cell lines, caffeine-induced activation of CDC2 kinase was detected only in cells arrested at G2 and CDC2 kinase-activated cells died exhibiting features of apoptosis.	Caffeine	20-28	cyclin dependent kinase 1	Homo sapiens	51-55
11120603-6	2001	In both cell lines, caffeine-induced activation of CDC2 kinase was detected only in cells arrested at G2 and CDC2 kinase-activated cells died exhibiting features of apoptosis.	Caffeine	20-28	cyclin dependent kinase 1	Homo sapiens	109-113
11120603-8	2001	Furthermore, cycloheximide inhibited activation of CDK2:cyclin A, which normally precedes CDC2 kinase activation in caffeine-treated cells.	Caffeine	116-124	cyclin dependent kinase 2	Homo sapiens	51-55
11120603-8	2001	Furthermore, cycloheximide inhibited activation of CDK2:cyclin A, which normally precedes CDC2 kinase activation in caffeine-treated cells.	Caffeine	116-124	cyclin A2	Homo sapiens	56-64
11120603-8	2001	Furthermore, cycloheximide inhibited activation of CDK2:cyclin A, which normally precedes CDC2 kinase activation in caffeine-treated cells.	Caffeine	116-124	cyclin dependent kinase 1	Homo sapiens	90-94
24921690-8	2001	Caffeine can inhibit the metabolism of some psychotropic drugs such as clozapine through the competitive inhibition of CYP 1A2 .	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-126
24921690-9	2001	Potent inhibitors of CYP 1A2 such as fluvoxamine can precipitate caffeine toxicity.	Caffeine	65-73	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-28
11368311-0	2000	Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.	Caffeine	78-86	glycophorin A (MNS blood group)	Homo sapiens	50-74
11368311-1	2000	Caffeine, an allosteric inhibitor of glycogen phosphorylase a (GPa), has been shown to act synergistically with the potential antidiabetic drug (-)(S)-3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate (W1807).	Caffeine	0-8	glycophorin A (MNS blood group)	Homo sapiens	37-61
11368311-1	2000	Caffeine, an allosteric inhibitor of glycogen phosphorylase a (GPa), has been shown to act synergistically with the potential antidiabetic drug (-)(S)-3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate (W1807).	Caffeine	0-8	glycophorin A (MNS blood group)	Homo sapiens	63-66
11368311-2	2000	The structure of GPa complexed with caffeine and W1807 has been determined at 100K to 2.3 A resolution, and refined to a crystallographic R value of 0.210 (Rfree = 0.257).	Caffeine	36-44	glycophorin A (MNS blood group)	Homo sapiens	17-20
11118510-1	2000	This study examined the effect of ingesting caffeine (6 mg kg-1) on muscle carbohydrate and fat metabolism during steady-state exercise in humans.	Caffeine	44-52	FAT atypical cadherin 1	Homo sapiens	92-95
11147835-0	2000	Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements.	Caffeine	15-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-75
11123973-0	2000	Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group.	Caffeine	38-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
11219055-6	2000	Caffeine could only be determined under positive ES-MS detection conditions and its detection limit was 0.01 ng mL-1.	Caffeine	0-8	L1 cell adhesion molecule	Mus musculus	112-116
11123973-2	2000	This study sought to identify the adduct that renders AChE refractory toward reactivation after inhibition with the (1S, 3S)-stereoisomer.	Caffeine	116-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-58
11123973-6	2000	In contrast, enzyme treated with the (1S,3S)-enantiomer had spontaneous and 2-PAM-mediated k(3) values of 0 and 6.05 x 10(3) min(-)(1), respectively.	Caffeine	37-43	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	78-81
11099373-6	2000	The first 500 m of the 2,000 m was faster with the higher caffeine dose compared with placebo or the lower dose (1.53 +/- 0.52 vs.1.55 +/- 0.62 and 1.	Caffeine	58-66	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	144-149
11069774-1	2000	CCZ1 was previously identified by the sensitivity of ccz1(delta) mutants to high concentrations of Caffeine and the divalent ions Ca(2+ )and Zn(2+).	Caffeine	99-107	Ccz1p	Saccharomyces cerevisiae S288C	0-4
11069774-1	2000	CCZ1 was previously identified by the sensitivity of ccz1(delta) mutants to high concentrations of Caffeine and the divalent ions Ca(2+ )and Zn(2+).	Caffeine	99-107	Ccz1p	Saccharomyces cerevisiae S288C	53-57
11126366-0	2000	Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.	Caffeine	107-115	X-ray repair cross complementing 2	Homo sapiens	138-143
11126366-3	2000	We show that a radiosensitive cell line, mutant for the RAD51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays significantly diminished caffeine radiosensitization that can be restored by expression of XRCC2.	Caffeine	166-174	RAD51 recombinase	Homo sapiens	56-61
11126366-3	2000	We show that a radiosensitive cell line, mutant for the RAD51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays significantly diminished caffeine radiosensitization that can be restored by expression of XRCC2.	Caffeine	166-174	X-ray repair cross complementing 2	Homo sapiens	70-75
11126366-3	2000	We show that a radiosensitive cell line, mutant for the RAD51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays significantly diminished caffeine radiosensitization that can be restored by expression of XRCC2.	Caffeine	166-174	X-ray repair cross complementing 2	Homo sapiens	232-237
11126366-4	2000	Despite the reduced radiosensitization, caffeine effectively abrogates checkpoints in S and G2 phases in XRCC2 mutant cells indicating that checkpoint abrogation is not sufficient for radiosensitization.	Caffeine	40-48	X-ray repair cross complementing 2	Homo sapiens	105-110
11126366-5	2000	Another radiosensitive line, mutant for XRCC3 and defective in HRR, similarly shows reduced caffeine radiosensitization.	Caffeine	92-100	X-ray repair cross complementing 3	Homo sapiens	40-45
11053126-8	2000	Although RyR3-expressing myotubes were more sensitive to caffeine than those expressing RyR1, they were much less sensitive to 4-chloro-m-cresol (CMC).	Caffeine	57-65	ryanodine receptor 3	Homo sapiens	9-13
11053126-9	2000	In RyR1-expressing cells, regenerative calcium oscillations were observed in response to caffeine and CMC but were never seen in RyR3-expressing 1B5 cells.	Caffeine	89-97	ryanodine receptor 1, skeletal muscle	Mus musculus	3-7
11200081-8	2000	Melittin, a potent phospholipase A2 activator, and reagent arachidonic acid mimicked the effects of caffeine, ATP or pyruvate on the tert-butylhydroperoxide-induced DNA single strand breakage.	Caffeine	100-108	phospholipase A2 group IB	Homo sapiens	19-35
11082111-9	2000	Ang II (0.001 - 0.3 microM) elevated [Ca(2+)](i) in single vascular smooth muscle cells (VSMCs) in a dose-dependent manner (pEC(50) 9.12+/-0.26) and the Ang II-induced increases in [Ca(2+)](i) were not affected by a Ca(2+)-free solution, but were abolished by pretreatment with caffeine (5 mM).	Caffeine	278-286	angiotensinogen	Rattus norvegicus	0-6
11082111-9	2000	Ang II (0.001 - 0.3 microM) elevated [Ca(2+)](i) in single vascular smooth muscle cells (VSMCs) in a dose-dependent manner (pEC(50) 9.12+/-0.26) and the Ang II-induced increases in [Ca(2+)](i) were not affected by a Ca(2+)-free solution, but were abolished by pretreatment with caffeine (5 mM).	Caffeine	278-286	angiogenin	Rattus norvegicus	0-3
11100940-4	2000	CYP activity in vivo was evaluated with breath tests using substrates specific for different isoenzymes: caffeine (CYP1A2), aminopyrine (CYP2C11), nitrosodimethylamine (CYP2E1), and erythromycin (CYP3A).	Caffeine	105-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3
11038159-6	2000	In vivo cytochrome P450 activity was evaluated with breath tests using substrates for different isoenzymes: caffeine (CYP1A2), aminopyrine (CYP2C11), and erythromycin (CYP3A2).	Caffeine	108-116	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-23
11038159-6	2000	In vivo cytochrome P450 activity was evaluated with breath tests using substrates for different isoenzymes: caffeine (CYP1A2), aminopyrine (CYP2C11), and erythromycin (CYP3A2).	Caffeine	108-116	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	118-124
11038159-12	2000	The caffeine (CYP1A2) breath tests remained comparable to controls.	Caffeine	4-12	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	14-20
11071923-0	2000	Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation.	Caffeine	122-130	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	87-91
11063719-7	2000	Expression of the mutant RYR1 cDNA produced channels with increased caffeine sensitivity and a significantly reduced maximal level of Ca(2+) release.	Caffeine	68-76	ryanodine receptor 1	Homo sapiens	25-29
11071923-10	2000	High dosage expression of a truncated mutant of int6(+) conferred a hypersensitivity to caffeine, but did not cause the defect in meiosis.	Caffeine	88-96	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	48-52
10915798-9	2000	Necdin enhanced the cytoplasmic retention of NEFA-GFP and potentiated the effect of NEFA-GFP on caffeine-evoked elevation of cytosolic Ca(2+) levels.	Caffeine	96-104	necdin, MAGE family member	Mus musculus	0-6
11061577-6	2000	RESULTS: The median CYP1A2 metabolic ratio after administration of caffeine + dextromethorphan was not significantly different from that obtained with the cocktail (P = .84).	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
11012552-4	2000	METHODS CYP1A2 activity was assessed using saliva paraxanthine (PX) to caffeine (CA) ratios.	Caffeine	71-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
11012552-12	2000	The observed decrease in the elimination half-life of caffeine in PD may be caused by increased CYP2E1 activity, an enzyme that also contributes to the metabolism of caffeine.	Caffeine	54-62	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
11012552-12	2000	The observed decrease in the elimination half-life of caffeine in PD may be caused by increased CYP2E1 activity, an enzyme that also contributes to the metabolism of caffeine.	Caffeine	166-174	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
11012553-0	2000	In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms.	Caffeine	127-135	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	147-151
11012553-1	2000	UNLABELLED: AIMS To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO.	Caffeine	101-109	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	42-46
11012553-6	2000	RESULTS CYP1A2, but none of the human FMOs, catalysed metabolism of caffeine.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
10998347-8	2000	Comparison of the effect of caffeine on wt-RyR1 and DeltaD3-RyR1 suggested that D3 is an important region of RyR that participates in Ca(2+)-dependent activation and inactivation of the Ca(2+)-release channel.	Caffeine	28-36	ryanodine receptor 1	Homo sapiens	43-47
10998347-8	2000	Comparison of the effect of caffeine on wt-RyR1 and DeltaD3-RyR1 suggested that D3 is an important region of RyR that participates in Ca(2+)-dependent activation and inactivation of the Ca(2+)-release channel.	Caffeine	28-36	ryanodine receptor 1	Homo sapiens	43-46
11018103-7	2000	Reducing pHi (i) increased whole cell intracellular [Ca2+] transients induced either electrically or by addition of caffeine, whereas (ii) it decreased spontaneous Ca2+ spark frequency.	Caffeine	116-124	glucose-6-phosphate isomerase	Rattus norvegicus	9-12
11032782-1	2000	We have investigated the effects on spontaneous SR Ca release of modulating the sarcoplasmic reticulum ryanodine receptor (RyR) with low (&lt;0.5 mM) concentrations of caffeine.	Caffeine	168-176	ryanodine receptor 2	Rattus norvegicus	103-121
11032782-1	2000	We have investigated the effects on spontaneous SR Ca release of modulating the sarcoplasmic reticulum ryanodine receptor (RyR) with low (&lt;0.5 mM) concentrations of caffeine.	Caffeine	168-176	ryanodine receptor 2	Rattus norvegicus	123-126
10952912-8	2000	Conversely, treatment of 72-h-cultured aged oocytes with caffeine (last 10 h of culture) decreased the level of pre-MPF and elevated MPF activity.	Caffeine	57-65	mesothelin	Homo sapiens	116-119
11120451-1	2000	We have previously shown that the combination of caffeine, carnitine, and choline supplementation decreased body fat and serum leptin concentration in rats and was attributed to increased fat utilization for energy.	Caffeine	49-57	leptin	Rattus norvegicus	127-133
11025658-1	2000	Here we show that exposure of aphidicolin-arrested Chinese hamster ovary (CHO) cells to the protein-kinase inhibitors 2-aminopurine or caffeine results in initiation of replication at successively later-replicating chromosomal domains, loss of the capacity to synthesize DNA at earlier-replicating sites, release of Mcm2 proteins from chromatin, and redistribution of PCNA and RPA from early- to late-replicating domains in the absence of detectable elongation of replication forks.	Caffeine	135-143	DNA replication licensing factor MCM2	Cricetulus griseus	316-320
11025658-1	2000	Here we show that exposure of aphidicolin-arrested Chinese hamster ovary (CHO) cells to the protein-kinase inhibitors 2-aminopurine or caffeine results in initiation of replication at successively later-replicating chromosomal domains, loss of the capacity to synthesize DNA at earlier-replicating sites, release of Mcm2 proteins from chromatin, and redistribution of PCNA and RPA from early- to late-replicating domains in the absence of detectable elongation of replication forks.	Caffeine	135-143	proliferating cell nuclear antigen	Cricetulus griseus	368-372
10952912-8	2000	Conversely, treatment of 72-h-cultured aged oocytes with caffeine (last 10 h of culture) decreased the level of pre-MPF and elevated MPF activity.	Caffeine	57-65	mesothelin	Homo sapiens	133-136
10987287-0	2000	Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.	Caffeine	58-66	transformation related protein 53, pseudogene	Mus musculus	129-132
10987287-3	2000	The stimulatory effect of green tea and caffeine on UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects of tea and caffeine on UV-induced carcinogenesis.	Caffeine	40-48	transformation related protein 53, pseudogene	Mus musculus	90-93
10987287-0	2000	Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.	Caffeine	58-66	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	134-137
10987287-3	2000	The stimulatory effect of green tea and caffeine on UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects of tea and caffeine on UV-induced carcinogenesis.	Caffeine	40-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	110-113
10987287-3	2000	The stimulatory effect of green tea and caffeine on UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects of tea and caffeine on UV-induced carcinogenesis.	Caffeine	40-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	114-123
10987287-0	2000	Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.	Caffeine	58-66	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	138-142
10934242-10	2000	Caffeine increased c-fos only in D(2)R(-/-) globus pallidus.	Caffeine	0-8	FBJ osteosarcoma oncogene	Mus musculus	19-24
11210826-0	2000	The effect of caffeine on p53-dependent radioresponses in undifferentiated mouse embryonal carcinoma cells after X-ray and UV-irradiations.	Caffeine	14-22	transformation related protein 53, pseudogene	Mus musculus	26-29
11210826-10	2000	Therefore, the effects of caffeine on the p53-dependent radioresponses were found to be agent specific: suppression for the X-ray induced and augmentation for the UV induced.	Caffeine	26-34	transformation related protein 53, pseudogene	Mus musculus	42-45
10963764-8	2000	Whereas paracetamol inhibited only COX enzyme activity, caffeine also inhibited COX-2 protein synthesis.	Caffeine	56-64	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	80-85
11109028-1	2000	We examined whether the acute treatment with caffeine delivered before an ethanol injection would augment plasma corticosterone (CORT) levels.	Caffeine	45-53	cortistatin	Rattus norvegicus	129-133
10920015-3	2000	Mutations of amino acids not absolutely conserved in RyRs and IP(3)Rs (D4903A and D4907A) showed cellular Ca(2+) release in response to caffeine, Ca(2+)-dependent [(3)H]ryanodine binding, and single-channel K(+) and Ca(2+) conductances not significantly different from wild-type RyR1.	Caffeine	136-144	ryanodine receptor 1	Homo sapiens	279-283
10920015-5	2000	Mutant channels with amino acid residue substitutions that are identical in the RyR and IP(3)R families (D4899A, D4899R, and R4913E) exhibited a decreased K(+) conductance and showed a loss of high-affinity [(3)H]ryanodine binding and loss of single-channel pharmacology but maintained their response to caffeine in a cellular assay.	Caffeine	304-312	ryanodine receptor 1	Homo sapiens	80-83
10920015-5	2000	Mutant channels with amino acid residue substitutions that are identical in the RyR and IP(3)R families (D4899A, D4899R, and R4913E) exhibited a decreased K(+) conductance and showed a loss of high-affinity [(3)H]ryanodine binding and loss of single-channel pharmacology but maintained their response to caffeine in a cellular assay.	Caffeine	304-312	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	88-94
10976659-10	2000	The polycyclic aromatic hydrocarbon-inducible cytochrome P450 (CYP) 1A2 participates in the metabolism of caffeine as well as of a number of clinically important drugs.	Caffeine	106-114	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-71
10976659-13	2000	Thus, pharmacokinetic interactions at the CYP1A2 enzyme level may cause toxic effects during concomitant administration of caffeine and certain drugs used for cardiovascular, CNS (an excessive dietary intake of caffeine has also been observed in psychiatric patients), gastrointestinal, infectious, respiratory and skin disorders.	Caffeine	123-131	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
10976659-13	2000	Thus, pharmacokinetic interactions at the CYP1A2 enzyme level may cause toxic effects during concomitant administration of caffeine and certain drugs used for cardiovascular, CNS (an excessive dietary intake of caffeine has also been observed in psychiatric patients), gastrointestinal, infectious, respiratory and skin disorders.	Caffeine	211-219	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
10976659-16	2000	Finally, caffeine is a useful and reliable probe drug for the assessment of CYP1A2 activity, which is of considerable interest for metabolic studies in human populations.	Caffeine	9-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
11109028-8	2000	It was argued that the present elevations in plasma CORT levels observed in animals administered caffeine and ethanol may play a role in the caffeine-induced elevations in ethanol drinking observed elsewhere.	Caffeine	97-105	cortistatin	Rattus norvegicus	52-56
11109028-8	2000	It was argued that the present elevations in plasma CORT levels observed in animals administered caffeine and ethanol may play a role in the caffeine-induced elevations in ethanol drinking observed elsewhere.	Caffeine	141-149	cortistatin	Rattus norvegicus	52-56
10971643-2	2000	and long-term peroral caffeine consumption for 10 days ( approximately 150 mg/kg/day in tap water) to affect cocaine self-administration in mice.	Caffeine	22-30	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	88-91
10971643-7	2000	A low dose of cocaine, by itself essentially ineffective, produced an increase in c-fos and NGFI-A mRNA in the cerebral cortex in mice that had been drinking caffeine.	Caffeine	158-166	early growth response 1	Mus musculus	92-98
10942180-0	2000	Evaluation of caffeine as an in vivo probe for CYP1A2 using measurements in plasma, saliva, and urine.	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
10971643-9	2000	Cocaine and caffeine also synergistically increased NGFI-A expression in caudate-putamen.	Caffeine	12-20	early growth response 1	Mus musculus	52-58
10920270-8	2000	These results suggest that in A549 cells, (i) capacitative Ca(2+) entry can also be regulated by caffeine/ryanodine-sensitive stores, and (ii) the RyR-gated stores interact functionally with those sensitive to IP(3), probably via Ca(2+)-induced Ca(2+) release.	Caffeine	97-105	ryanodine receptor 1	Homo sapiens	147-150
10923023-3	2000	Co-deletion of the MSB3 and MSB4 coding regions caused growth inhibition in the presence of 10 mM caffeine and 4% dimethyl sulphoxide (DMSO), increased the sensitivity of the yeast strain to latrunculin-A, produced a random budding pattern in diploid cells, and affected the organization of the actin cytoskeleton.	Caffeine	98-106	Rab GTPase-activating protein MSB3	Saccharomyces cerevisiae S288C	19-23
10923023-3	2000	Co-deletion of the MSB3 and MSB4 coding regions caused growth inhibition in the presence of 10 mM caffeine and 4% dimethyl sulphoxide (DMSO), increased the sensitivity of the yeast strain to latrunculin-A, produced a random budding pattern in diploid cells, and affected the organization of the actin cytoskeleton.	Caffeine	98-106	Rab GTPase-activating protein MSB4	Saccharomyces cerevisiae S288C	28-32
10904026-4	2000	Caffeine raised both systolic and diastolic BP (SBP and DBP, respectively; P&lt;0.0001 for both) in all groups.	Caffeine	0-8	selenium binding protein 1	Homo sapiens	48-51
10900244-6	2000	Moreover, in the presence of caffeine, force of contraction was increased only in CSQ and NCX/CSQ and was accompanied by elevated diastolic tension.	Caffeine	29-37	calsequestrin 1	Mus musculus	82-85
10900244-6	2000	Moreover, in the presence of caffeine, force of contraction was increased only in CSQ and NCX/CSQ and was accompanied by elevated diastolic tension.	Caffeine	29-37	T cell leukemia, homeobox 2	Mus musculus	90-93
10900244-6	2000	Moreover, in the presence of caffeine, force of contraction was increased only in CSQ and NCX/CSQ and was accompanied by elevated diastolic tension.	Caffeine	29-37	calsequestrin 1	Mus musculus	94-97
10900244-9	2000	The Ca(2+) transients and the L-type Ca(2+) currents in the presence of caffeine were very large in CSQ, but smaller increases were noted in double transgenic mice.	Caffeine	72-80	calsequestrin 1	Mus musculus	100-103
10864448-2	2000	The activity of the skeletal muscle (RyR1), cardiac muscle (RyR2), and brain (RyR3) ryanodine receptor isoforms have been shown to be highly regulated by physiological factors including pH, temperature, and ionic strength; endogenous compounds including Ca(2+), Mg(2+), and adenosine triphosphate (ATP); and pharmacological agents including caffeine, ruthenium red, and neomycin.	Caffeine	341-349	ryanodine receptor 3	Homo sapiens	78-82
10904026-7	2000	The potential clinical relevance of caffeine-induced BP changes is seen in the BPs that reached the hypertensive range (SBP &gt;/=140 mm Hg or DBP &gt;/=90 mm Hg) after caffeine.	Caffeine	36-44	selenium binding protein 1	Homo sapiens	120-123
10904026-7	2000	The potential clinical relevance of caffeine-induced BP changes is seen in the BPs that reached the hypertensive range (SBP &gt;/=140 mm Hg or DBP &gt;/=90 mm Hg) after caffeine.	Caffeine	36-44	D-box binding PAR bZIP transcription factor	Homo sapiens	143-146
10904026-4	2000	Caffeine raised both systolic and diastolic BP (SBP and DBP, respectively; P&lt;0.0001 for both) in all groups.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59
10904026-5	2000	However, an ANCOVA revealed that the strongest response to caffeine was observed among diagnosed men, followed by the stage 1 and high-normal groups and then by the normal and optimal groups (SBP F(4),(175)=5.06, P&lt;0.0001; DBP F(4,175)=3.02, P&lt;0.02).	Caffeine	59-67	selenium binding protein 1	Homo sapiens	192-195
10904026-5	2000	However, an ANCOVA revealed that the strongest response to caffeine was observed among diagnosed men, followed by the stage 1 and high-normal groups and then by the normal and optimal groups (SBP F(4),(175)=5.06, P&lt;0.0001; DBP F(4,175)=3.02, P&lt;0.02).	Caffeine	59-67	D-box binding PAR bZIP transcription factor	Homo sapiens	226-229
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Caffeine	83-91	carbonic anhydrase 2	Homo sapiens	55-58
10770932-6	2000	Interestingly, both DNA damage- and bFGF-induced effects on cdc2 phosphorylation are reverted by caffeine.	Caffeine	97-105	fibroblast growth factor 2	Homo sapiens	36-40
10770932-6	2000	Interestingly, both DNA damage- and bFGF-induced effects on cdc2 phosphorylation are reverted by caffeine.	Caffeine	97-105	cyclin dependent kinase 1	Homo sapiens	60-64
10764737-3	2000	We now report that PC12 cells expressing PS1 mutations and primary hippocampal neurons from PS1 mutant knockin mice exhibit greatly increased levels of ryanodine receptors (RyR) and enhanced Ca(2+) release following stimulation with caffeine.	Caffeine	233-241	presenilin 1	Rattus norvegicus	41-44
10764737-3	2000	We now report that PC12 cells expressing PS1 mutations and primary hippocampal neurons from PS1 mutant knockin mice exhibit greatly increased levels of ryanodine receptors (RyR) and enhanced Ca(2+) release following stimulation with caffeine.	Caffeine	233-241	presenilin 1	Rattus norvegicus	92-95
10764737-3	2000	We now report that PC12 cells expressing PS1 mutations and primary hippocampal neurons from PS1 mutant knockin mice exhibit greatly increased levels of ryanodine receptors (RyR) and enhanced Ca(2+) release following stimulation with caffeine.	Caffeine	233-241	ryanodine receptor 1, skeletal muscle	Mus musculus	173-176
10764737-5	2000	Caffeine treatment sensitizes neurons expressing mutant PS1 to apoptosis induced by amyloid beta-peptide, a neurotic peptide linked to the pathogenesis of AD.	Caffeine	0-8	presenilin 1	Rattus norvegicus	56-59
10856121-10	2000	FK506 (10 microM) did not affect IP3-induced Ca2+ release in permeabilized SH-SY5Y and A7r5 cells, but enhanced caffeine-induced Ca2+ release via the ryanodine receptor (RyR) in differentiated BC3H1 cells.	Caffeine	112-120	ryanodine receptor 2	Rattus norvegicus	150-168
11679204-5	2000	Caffeine, a CICR or ryanodine receptor (RYR) activator, produced a rapid Ca(2+) release with a 330 nM increase in [Ca(2+)](i).	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	20-38
11679204-5	2000	Caffeine, a CICR or ryanodine receptor (RYR) activator, produced a rapid Ca(2+) release with a 330 nM increase in [Ca(2+)](i).	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	40-43
11679204-6	2000	Pretreatment of the CASMCs with SNP, CICR inhibitor tetracaine or RYR blocker ryanodine markedly decreased caffeine-induced Ca(2+) release.	Caffeine	107-115	ryanodine receptor 1	Homo sapiens	66-69
10837142-6	2000	Astrocytes in cerebellar cultures derived from 6-day-old S100B null mice exhibited enhanced Ca(2+) transients in response to treatment with KCl or caffeine.	Caffeine	147-155	S100 protein, beta polypeptide, neural	Mus musculus	57-62
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Caffeine	83-91	carbonic anhydrase 2	Homo sapiens	102-105
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Caffeine	83-91	carbonic anhydrase 2	Homo sapiens	102-105
10809772-5	2000	We also report that genistein activates the checkpoint kinase Chk2 as efficiently as the two genotoxic agents and that caffeine may counteract the activation of Chk2 by genistein but not by etoposide.	Caffeine	119-127	checkpoint kinase 2	Homo sapiens	161-165
10852448-6	2000	At the same time, plasma beta-endorphin levels almost doubled (from 30 +/- 5 to 53 +/- 13 pg/mL; P &lt; 0.05) in the caffeine-treated group, whereas no change occurred in the placebo group.	Caffeine	117-125	proopiomelanocortin	Homo sapiens	25-39
10852448-8	2000	However, these data suggest that caffeine lowers the threshold for exercise-induced beta-endorphin and cortisol release, which may contribute to the reported benefits of caffeine on exercise endurance.	Caffeine	33-41	proopiomelanocortin	Homo sapiens	84-98
10852448-8	2000	However, these data suggest that caffeine lowers the threshold for exercise-induced beta-endorphin and cortisol release, which may contribute to the reported benefits of caffeine on exercise endurance.	Caffeine	170-178	proopiomelanocortin	Homo sapiens	84-98
10809772-6	2000	In contrast, caffeine abolishes the accumulation of p53 caused by all the compounds.	Caffeine	13-21	tumor protein p53	Homo sapiens	52-55
10781282-3	2000	The immunosuppressant drugs FK506 (tacrolimus) and rapamycin can promote dissociation of FK506 binding protein from the ryanodine receptor 1 and by this mechanism increase sensitivity of ryanodine receptor 1 to agonists such as caffeine.	Caffeine	228-236	ryanodine receptor 1	Homo sapiens	120-140
10805724-4	2000	Deletion of YNG2 results in several phenotypes, including an abnormal multibudded morphology, an inability to utilize nonfermentable carbon sources, heat shock sensitivity, slow growth, temperature sensitivity, and sensitivity to caffeine.	Caffeine	230-238	histone acetyltransferase YNG2	Saccharomyces cerevisiae S288C	12-16
10781282-3	2000	The immunosuppressant drugs FK506 (tacrolimus) and rapamycin can promote dissociation of FK506 binding protein from the ryanodine receptor 1 and by this mechanism increase sensitivity of ryanodine receptor 1 to agonists such as caffeine.	Caffeine	228-236	ryanodine receptor 1	Homo sapiens	187-207
10762633-1	2000	Caffeine inhibits the G2 checkpoint activated by DNA damage and enhances the toxicity of DNA-damaging agents towards p53-defective cancer cells.	Caffeine	0-8	tumor protein p53	Homo sapiens	117-120
10773407-0	2000	Caffeine enhanced radiosensitivity of rat tumor cells with a mutant-type p53 by inducing apoptosis in a p53-independent manner.	Caffeine	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	73-76
10773407-0	2000	Caffeine enhanced radiosensitivity of rat tumor cells with a mutant-type p53 by inducing apoptosis in a p53-independent manner.	Caffeine	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	104-107
10773407-4	2000	Radiosensitization of caffeine was recognized even in a higher dose range for cells with a mutant-type p53.	Caffeine	22-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	103-106
10773407-5	2000	Apoptosis, which was not prominent after irradiation alone or caffeine treatment alone, was induced by irradiation in combination with caffeine in cells with a mutant-type p53 through a p53-independent pathway.	Caffeine	135-143	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	172-175
10773407-5	2000	Apoptosis, which was not prominent after irradiation alone or caffeine treatment alone, was induced by irradiation in combination with caffeine in cells with a mutant-type p53 through a p53-independent pathway.	Caffeine	135-143	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	186-189
10877010-9	2000	CYP1A2 activity, measured by the plasma ratios of paraxanthine: caffeine, was significantly lower in kwashiorkor and malaria.	Caffeine	64-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
10839467-0	2000	Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women.	Caffeine	30-38	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
10860400-9	2000	It is considered that the synthesis and release of parathyroid hormone is stimulated following caffeine consumption.	Caffeine	95-103	parathyroid hormone	Mesocricetus auratus	51-70
10837840-12	2000	Significant dose-response relationships to caffeine were seen only for SBP, heart rate, and skin temperature.	Caffeine	43-51	selenium binding protein 1	Homo sapiens	71-74
10757807-2	2000	We identified cid1, a novel fission yeast gene, through its ability when overexpressed to confer specific resistance to a combination of hydroxyurea, which inhibits DNA replication, and caffeine, which overrides the S-M checkpoint.	Caffeine	186-194	type 1 serine/threonine-protein phosphatase catalytic subunit GLC7	Saccharomyces cerevisiae S288C	14-18
10757807-6	2000	Cells lacking Cid1 were found to be viable but specifically sensitive to the combination of hydroxyurea and caffeine and to be S-M checkpoint defective in the absence of Cds1.	Caffeine	108-116	type 1 serine/threonine-protein phosphatase catalytic subunit GLC7	Saccharomyces cerevisiae S288C	14-18
10766921-15	2000	In sharp contrast, low (0.5 mM) caffeine concentrations that produced no measurable effects on ICa or Ca2+ transients in control myocytes, re-established spontaneous focal Ca2+ releases in CSQ-overexpressing cells, triggered large ICa-gated cellular Ca2+ transients, and strongly enhanced the kinetics of inactivation of ICa.	Caffeine	32-40	inhibitor of carbonic anhydrase	Mus musculus	231-234
10766921-15	2000	In sharp contrast, low (0.5 mM) caffeine concentrations that produced no measurable effects on ICa or Ca2+ transients in control myocytes, re-established spontaneous focal Ca2+ releases in CSQ-overexpressing cells, triggered large ICa-gated cellular Ca2+ transients, and strongly enhanced the kinetics of inactivation of ICa.	Caffeine	32-40	inhibitor of carbonic anhydrase	Mus musculus	231-234
11232603-8	2000	The effects of the VP-16 phenoxyl radical on Ca2+-ATPase in SR vesicles resembled those observed with caffeine or 4,4"-dithiodipyridine, both of which activate RyR Ca2+ release and lead to activation of Ca2+-ATPase via prolonged Ca2+ cycling.	Caffeine	102-110	host cell factor C1	Homo sapiens	19-24
10744722-0	2000	Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	76-105
10744722-3	2000	Prior treatment of cells with 2 mM caffeine inhibits such a change and markedly reduces radiation-induced ataxia-telangiectasia-mutated (ATM)-dependent Chk2/Cds1 activation and phosphorylation.	Caffeine	35-43	ATM serine/threonine kinase	Homo sapiens	106-135
10744722-3	2000	Prior treatment of cells with 2 mM caffeine inhibits such a change and markedly reduces radiation-induced ataxia-telangiectasia-mutated (ATM)-dependent Chk2/Cds1 activation and phosphorylation.	Caffeine	35-43	ATM serine/threonine kinase	Homo sapiens	137-140
10744722-3	2000	Prior treatment of cells with 2 mM caffeine inhibits such a change and markedly reduces radiation-induced ataxia-telangiectasia-mutated (ATM)-dependent Chk2/Cds1 activation and phosphorylation.	Caffeine	35-43	checkpoint kinase 2	Homo sapiens	152-156
10744722-3	2000	Prior treatment of cells with 2 mM caffeine inhibits such a change and markedly reduces radiation-induced ataxia-telangiectasia-mutated (ATM)-dependent Chk2/Cds1 activation and phosphorylation.	Caffeine	35-43	CDP-diacylglycerol synthase 1	Homo sapiens	157-161
10744722-5	2000	Caffeine does not inhibit Chk2/Cds1 activity directly, but rather, blocks the activation of Chk2/Cds1 by inhibiting ATM kinase activity.	Caffeine	0-8	checkpoint kinase 2	Homo sapiens	92-96
10744722-5	2000	Caffeine does not inhibit Chk2/Cds1 activity directly, but rather, blocks the activation of Chk2/Cds1 by inhibiting ATM kinase activity.	Caffeine	0-8	CDP-diacylglycerol synthase 1	Homo sapiens	97-101
10744722-5	2000	Caffeine does not inhibit Chk2/Cds1 activity directly, but rather, blocks the activation of Chk2/Cds1 by inhibiting ATM kinase activity.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	116-119
10744722-7	2000	Using a phospho-specific antibody against threonine 68, we demonstrate that radiation-induced, ATM-dependent phosphorylation of Chk2/Cds1 at this site is caffeine-sensitive.	Caffeine	154-162	ATM serine/threonine kinase	Homo sapiens	95-98
10744722-7	2000	Using a phospho-specific antibody against threonine 68, we demonstrate that radiation-induced, ATM-dependent phosphorylation of Chk2/Cds1 at this site is caffeine-sensitive.	Caffeine	154-162	checkpoint kinase 2	Homo sapiens	128-132
10744722-7	2000	Using a phospho-specific antibody against threonine 68, we demonstrate that radiation-induced, ATM-dependent phosphorylation of Chk2/Cds1 at this site is caffeine-sensitive.	Caffeine	154-162	CDP-diacylglycerol synthase 1	Homo sapiens	133-137
10744722-8	2000	From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint by targeting the ATM-Chk2/Cds1 pathway; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.	Caffeine	47-55	ATM serine/threonine kinase	Homo sapiens	105-108
10744722-8	2000	From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint by targeting the ATM-Chk2/Cds1 pathway; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.	Caffeine	47-55	checkpoint kinase 2	Homo sapiens	109-113
10744722-8	2000	From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint by targeting the ATM-Chk2/Cds1 pathway; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.	Caffeine	47-55	CDP-diacylglycerol synthase 1	Homo sapiens	114-118
10744722-8	2000	From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint by targeting the ATM-Chk2/Cds1 pathway; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.	Caffeine	47-55	ATM serine/threonine kinase	Homo sapiens	142-145
10744722-8	2000	From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint by targeting the ATM-Chk2/Cds1 pathway; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.	Caffeine	47-55	cell division cycle 25C	Homo sapiens	193-199
10744722-9	2000	Inhibition of ATM provides a molecular explanation for the increased radiosensitivity of caffeine-treated cells.	Caffeine	89-97	ATM serine/threonine kinase	Homo sapiens	14-17
11232603-8	2000	The effects of the VP-16 phenoxyl radical on Ca2+-ATPase in SR vesicles resembled those observed with caffeine or 4,4"-dithiodipyridine, both of which activate RyR Ca2+ release and lead to activation of Ca2+-ATPase via prolonged Ca2+ cycling.	Caffeine	102-110	ryanodine receptor 1	Homo sapiens	160-163
10742303-11	2000	The depressant effects induced by high doses of caffeine were lost in control CD1 mice habituated to the open field.	Caffeine	48-56	CD1 antigen complex	Mus musculus	78-81
21432205-0	2000	Acute caffeine effect on repeatedly measured P300.	Caffeine	6-14	E1A binding protein p300	Homo sapiens	45-49
21432205-1	2000	The acute effect of a single-dose of caffeine on the P300 event-related brain potential (ERP) was assessed in a study using a repeatedly presented auditory oddball button-press task.	Caffeine	37-45	ETS transcription factor ELK3	Homo sapiens	53-93
21432205-3	2000	The caffeine-treatment condition demonstrated a smaller P300 amplitude and a shorter latency overall than the placebo treatment condition.	Caffeine	4-12	E1A binding protein p300	Homo sapiens	56-60
21432205-4	2000	The mean P300 amplitude value difference (caffeine minus placebo) increased with the successive trial blocks.	Caffeine	42-50	E1A binding protein p300	Homo sapiens	9-13
10720630-4	2000	It is concluded that stimulation of the sarcoplasmic reticulum Ca(2+) release channel accounts for the dichlorobenzamil- or phenamil-induced tension in skinned fibers, whereas depletion of sarcoplasmic reticulum Ca(2+) stores and channel block (with dichlorobenzamil) explains the inhibition of the caffeine-evoked tension by amiloride analogs.	Caffeine	299-307	ryanodine receptor 2	Oryctolagus cuniculus	63-85
10733959-5	2000	Sensitivity to caffeine (0.1 mM) was remarkably different, with sparks in RyR-1 null myotubes becoming brighter and longer in duration, whereas those in RyR-3 null cells remained unchanged.	Caffeine	15-23	ryanodine receptor 1, skeletal muscle	Mus musculus	74-77
10733962-7	2000	Caffeine increased not only the affinity of the A-site for Ca(2+) alone, but also the maximum activity of RyR with otherwise minor changes.	Caffeine	0-8	ryanodine receptor 2	Homo sapiens	106-109
10741629-11	2000	CONCLUSIONS: Results of this caffeine metabolism study conducted with age- and gender-matched healthy Korean volunteers with and without smoking habits provided the baseline and the widely varying interindividual activities of CYP1A2, FMO, and xanthine oxidase in a Korean population.	Caffeine	29-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	227-233
10718779-0	2000	The effect of NAT2 genotype and gender on the metabolism of caffeine in nonsmoking subjects.	Caffeine	60-68	N-acetyltransferase 2	Homo sapiens	14-18
10738085-3	2000	RESULTS: The radiosensitizing effect of caffeine (2 mM) expressed itself as a significant decrease in surviving fraction at 2 Gy and a significant increase in alpha-values in RT112 and TE671, both with non-functional p53.	Caffeine	40-48	tumor protein p53	Homo sapiens	217-220
10683156-3	2000	Arrested cells accumulate cyclin B, the regulatory partner of the mitotic p34(cdc2) kinase, which is normally not abundant until late G(2) phase; treatment of arrested cells with caffeine produces rapid S-phase condensation.	Caffeine	179-187	alpha and gamma adaptin binding protein	Homo sapiens	74-77
10683156-3	2000	Arrested cells accumulate cyclin B, the regulatory partner of the mitotic p34(cdc2) kinase, which is normally not abundant until late G(2) phase; treatment of arrested cells with caffeine produces rapid S-phase condensation.	Caffeine	179-187	cyclin dependent kinase 1	Homo sapiens	78-82
10683156-4	2000	We show here that such S-phase checkpoint slippage, as visualised through caffeine-dependent S-phase condensation, correlates with rodent origin and transformed status, is opposed by reverse transformation, and is favoured by c-src and opposed by wnt1 overexpression.	Caffeine	74-82	Wnt family member 1	Homo sapiens	247-251
10738085-9	2000	CONCLUSION: The data presented confirm that p53 status can be a significant determinant of the efficacy of caffeine as radiosensitizer in these tumour cell lines, and document the importance of the G2 checkpoint in this effect.	Caffeine	107-115	tumor protein p53	Homo sapiens	44-47
10671909-3	2000	CYP1A2 activity was measured by plasma paraxanthine/caffeine (1,7X/1,3,7X) ratio 6 h after administration of 300 mg caffeine.	Caffeine	52-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
10803761-10	2000	Seven days after both PAN injections, increased plasma renin activity was detected in animals that were consuming caffeine as compared with corresponding control groups (CAFF and CAFF + PAN vs CON and PAN, respectively).	Caffeine	114-122	renin	Rattus norvegicus	55-60
10803761-14	2000	In conclusion, this study indicates that caffeine adversely affects renal function in PAN-nephrotic rats, and that this effect may be due, in part, to increased activity of the renin angiotensin system.	Caffeine	41-49	renin	Rattus norvegicus	177-182
10681587-3	2000	Interestingly, tfb3(ts) failed to grow on medium containing caffeine.	Caffeine	60-68	TFIIH/NER complex subunit TFB3	Saccharomyces cerevisiae S288C	15-23
10671909-3	2000	CYP1A2 activity was measured by plasma paraxanthine/caffeine (1,7X/1,3,7X) ratio 6 h after administration of 300 mg caffeine.	Caffeine	116-124	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
11790342-5	2000	The mammalian CYP1A2 inhibitor furafylline (50 microM-1 mM) reduced activity in the EROD, caffeine and POD assays to 65, 21 and 20% of control values in flounders and to 85, 10 and 5% of control values in eels, respectively.	Caffeine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
10685865-8	2000	The effects on CCK-8-induced elevation of [Ca2+]i and amylase secretion were paradoxical, the caffeine inhibition being more pronounced at high than at low concentrations of CCK-8.	Caffeine	94-102	cholecystokinin	Cavia porcellus	15-18
10720162-0	2000	Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise.	Caffeine	0-8	leptin	Rattus norvegicus	85-91
10685865-8	2000	The effects on CCK-8-induced elevation of [Ca2+]i and amylase secretion were paradoxical, the caffeine inhibition being more pronounced at high than at low concentrations of CCK-8.	Caffeine	94-102	cholecystokinin	Cavia porcellus	174-177
10685865-9	2000	This enigma was further emphasized by moderate effects of caffeine on the responses to CCK-JMV-180.	Caffeine	58-66	cholecystokinin	Cavia porcellus	87-90
10728918-5	2000	Caffeine metabolism and inhibition studies by furafylline, CYP1A1 antiserum and ketoconazole revealed that the differences in the expression of CYP1A1 and CYP1A2 in the two tissues led to significant changes in the contribution of the various isoenzymes involved in the biotransformation of caffeine.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	144-150
10678296-12	2000	Based on in vitro reports of antipyrine metabolism and current caffeine metabolic index data, the predominant effect of type 1 diabetes appears to be an increase in CYP1A2 activity.	Caffeine	63-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	165-171
10728918-5	2000	Caffeine metabolism and inhibition studies by furafylline, CYP1A1 antiserum and ketoconazole revealed that the differences in the expression of CYP1A1 and CYP1A2 in the two tissues led to significant changes in the contribution of the various isoenzymes involved in the biotransformation of caffeine.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	155-161
10728918-5	2000	Caffeine metabolism and inhibition studies by furafylline, CYP1A1 antiserum and ketoconazole revealed that the differences in the expression of CYP1A1 and CYP1A2 in the two tissues led to significant changes in the contribution of the various isoenzymes involved in the biotransformation of caffeine.	Caffeine	291-299	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	144-150
10728918-5	2000	Caffeine metabolism and inhibition studies by furafylline, CYP1A1 antiserum and ketoconazole revealed that the differences in the expression of CYP1A1 and CYP1A2 in the two tissues led to significant changes in the contribution of the various isoenzymes involved in the biotransformation of caffeine.	Caffeine	291-299	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	155-161
10728918-7	2000	In addition, other CYP enzymes (most probably CYP3A) play a significant role in theobromine and theophylline formation from caffeine in rat intestine.	Caffeine	124-132	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	46-51
10728918-9	2000	Furthermore in rat intestine cytochrome P450 isozymes such as CYP1A1 and CYP3A replace CYP1A2 in the caffeine metabolism.	Caffeine	101-109	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-68
10728918-9	2000	Furthermore in rat intestine cytochrome P450 isozymes such as CYP1A1 and CYP3A replace CYP1A2 in the caffeine metabolism.	Caffeine	101-109	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	73-78
10728918-9	2000	Furthermore in rat intestine cytochrome P450 isozymes such as CYP1A1 and CYP3A replace CYP1A2 in the caffeine metabolism.	Caffeine	101-109	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	87-93
11263245-8	2000	But caffeine directly inhibited the activation of JNK and decreased phospho-c-Jun in granule neurons.	Caffeine	4-12	mitogen-activated protein kinase 8	Homo sapiens	50-53
11263245-8	2000	But caffeine directly inhibited the activation of JNK and decreased phospho-c-Jun in granule neurons.	Caffeine	4-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
11263245-9	2000	CONCLUSION: Caffeine inhibited the activation of JNK and decreased the phosphorylation of c-Jun to protect granule neurons from LY294002-induced apoptosis.	Caffeine	12-20	mitogen-activated protein kinase 8	Homo sapiens	49-52
11263245-9	2000	CONCLUSION: Caffeine inhibited the activation of JNK and decreased the phosphorylation of c-Jun to protect granule neurons from LY294002-induced apoptosis.	Caffeine	12-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
10645903-5	2000	The ET-1-induced increase in [Ca(2+)](i) was attenuated (&lt;80%) by extracellular Ca(2+) removal; by verapamil, a voltage-gated Ca(2+)-channel antagonist; and by ryanodine, an inhibitor of Ca(2+) release from caffeine-sensitive stores.	Caffeine	210-218	endothelin 1	Rattus norvegicus	4-8
11783486-0	2000	Blockade of A1 receptors by caffeine induces c-fos, zif-268 and ARC expression in the striatum through different interactions with the dopamine system.	Caffeine	28-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
11783486-0	2000	Blockade of A1 receptors by caffeine induces c-fos, zif-268 and ARC expression in the striatum through different interactions with the dopamine system.	Caffeine	28-36	early growth response 1	Homo sapiens	52-59
11173867-6	2000	However, caffeine enhanced the induction of micronuclei by gamma irradiation only in normal and heterozygous AT cells but not in BRCA1 cells, thus indicating a difference in the pathways leading to mutagen sensitivity in cells with a BRCA1 or an AT mutation.	Caffeine	9-17	BRCA1 DNA repair associated	Homo sapiens	234-239
10769661-1	2000	The present study was performed to investigate whether the introduction of a wild-type p53 gene into human osteosarcoma cells could alter the growth rate and enhance the cytocidal effect of cisplatin (CDDP) and the synergistic antitumor effect of caffeine.	Caffeine	247-255	tumor protein p53	Homo sapiens	87-90
10769661-5	2000	Caffeine significantly potentiated the cytocidal effect of CDDP in the Saos2/p53 cells.	Caffeine	0-8	tumor protein p53	Homo sapiens	77-80
10769661-6	2000	Furthermore, the TUNEL assay revealed that following treatment both with CDDP alone and with CDDP combined with caffeine, a higher percentage of the Saos2/p53 cells underwent apoptosis than did the parental Saos2 cells.	Caffeine	112-120	tumor protein p53	Homo sapiens	155-158
10769661-7	2000	Therefore the cytocidal effect of CDDP and the synergistic antitumor effect of caffeine are enhanced by the introduction of a wild-type p53 gene into a human osteosarcoma cell line null for p53.	Caffeine	79-87	tumor protein p53	Homo sapiens	136-139
11173867-7	2000	Our results suggest that caffeine could be useful in discriminating AT heterozygotes from carriers of a BRCA1 mutation, as well as BRCA1 mutation carriers from normal individuals.	Caffeine	25-33	BRCA1 DNA repair associated	Homo sapiens	104-109
10891619-9	2000	In summary, each of the anxiogenic drugs tested (FG-7142, yohimbine, m-chlorophenyl piperazine, caffeine and BOC-CCK(4)) increased Fos expression in a restricted number of hindbrain regions, including the periaqueductal gray and locus coeruleus.	Caffeine	96-104	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
10718633-8	2000	Activity of ADA was inhibited by the presence of theophylline (-40%), caffeine (-30%), and L-cysteine (-50%).	Caffeine	70-78	adenosine deaminase	Mus musculus	12-15
10647072-4	2000	Caffeine ingestion resulted in similar increases in younger and older women for plasma caffeine (younger, 80 +/- 34 to 5,604 +/- 528 ng/mL, P &lt; .01; older, 154 +/- 134 to 5,971 +/- 867 ng/mL, P &lt; .01) and fatty acids (younger, 294 +/- 118 to 798 +/- 248 micromol/L, P &lt; .01; older, 360 +/- 180 to 727 +/- 310 micromol/L, P &lt; .01), whereas plasma insulin and glucose levels remained unchanged from baseline.	Caffeine	0-8	insulin	Homo sapiens	358-365
10660069-5	2000	Deletion of RRD1 caused pleiotropic phenotypes under a wide range of conditions, including sensitivity to Ca2+, vanadate, ketoconazole, cycloheximide and Calcofluor white, and resistance to caffeine and rapamycin.	Caffeine	190-198	peptidylprolyl isomerase RRD1	Saccharomyces cerevisiae S288C	12-16
10707900-0	1999	Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.	Caffeine	82-90	carbonic anhydrase 1	Rattus norvegicus	99-102
10786933-10	2000	Caffeine in tea was also important for tea to prevent tumorigenesis.	Caffeine	0-8	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	12-15
10786933-10	2000	Caffeine in tea was also important for tea to prevent tumorigenesis.	Caffeine	0-8	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	39-42
10590314-5	1999	The presence of exogenously added CaM (10 microg/ml) markedly increased the caffeine (5-10 mM)-induced (45)Ca(2+) release and shifted the dose-response curve of caffeine-induced (45)Ca(2+) release to the left.	Caffeine	76-84	calmodulin 1	Rattus norvegicus	34-37
10590314-5	1999	The presence of exogenously added CaM (10 microg/ml) markedly increased the caffeine (5-10 mM)-induced (45)Ca(2+) release and shifted the dose-response curve of caffeine-induced (45)Ca(2+) release to the left.	Caffeine	161-169	calmodulin 1	Rattus norvegicus	34-37
10600531-0	1999	Regulation of phosphatidylserine synthesis in Jurkat T cell clones: caffeine bypasses CD3/TCR-induced protein tyrosine kinases and calcium signals.	Caffeine	68-76	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	90-93
10570017-1	1999	Caffeine metabolite ratios have been widely used to measure cytochrome P-450 1A2 activity in humans.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	60-80
10571245-2	1999	Caffeine has been shown to abrogate the S and G2 arrest in p53-defective cells and to enhance cytotoxicity, but at concentrations too toxic to administer to humans.	Caffeine	0-8	tumor protein p53	Homo sapiens	59-62
10780285-7	1999	When administered in combination with caffeine, both the DA D1 and DA D2 antagonists antagonized completely the discriminative stimulus effects of the low training dose of caffeine, but did not alter the discriminative stimulus effects of the high training dose.	Caffeine	172-180	defender against cell death 1	Rattus norvegicus	57-62
10780285-8	1999	These results suggest that the discriminative stimulus effects of 10 mg/kg of caffeine, but not 56 mg/kg of caffeine, are dependent on, but not limited to, DA D1 and D2 receptor mechanisms.	Caffeine	78-86	defender against cell death 1	Rattus norvegicus	156-161
10570017-5	1999	A statistically significant association (log-likelihood ratio = 25.0) between a locus on chromosome 9, which colocalized with the murine Cyp1a2 locus, and the plasma paraxanthine/caffeine ratio was identified.	Caffeine	179-187	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	137-143
10567689-5	1999	The DeltaD3-RyR1 channel retains its sensitivity to activation by caffeine, but is resistant to inactivation by Mg(2+).	Caffeine	66-74	ryanodine receptor 1	Homo sapiens	4-16
10701937-4	1999	In Vierordt"s method, A1(1) (1%, 1cm) values of paracetamol and caffeine were determined at 242.9 and 273.0 nm in zero-order spectra.	Caffeine	64-72	DXS435E	Homo sapiens	22-27
10597228-4	1999	In both cases, CDK1 from arrested cells could be reactivated both in vitro by dephosphorylation by recombinant Cdc25B phosphatase and in vivo by caffeine.	Caffeine	145-153	cyclin dependent kinase 1	Homo sapiens	15-19
10634135-0	1999	Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.	Caffeine	82-90	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
10634135-0	1999	Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.	Caffeine	82-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44
10634135-1	1999	Alprazolam (ALP) and caffeine (CAF) were suggested as probe drugs for the activities of CYP3A4 and CYP1A2, respectively.	Caffeine	21-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	88-94
10634135-1	1999	Alprazolam (ALP) and caffeine (CAF) were suggested as probe drugs for the activities of CYP3A4 and CYP1A2, respectively.	Caffeine	21-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	99-105
10634135-1	1999	Alprazolam (ALP) and caffeine (CAF) were suggested as probe drugs for the activities of CYP3A4 and CYP1A2, respectively.	Caffeine	31-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	88-94
10634135-1	1999	Alprazolam (ALP) and caffeine (CAF) were suggested as probe drugs for the activities of CYP3A4 and CYP1A2, respectively.	Caffeine	31-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	99-105
10597277-0	1999	ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.	Caffeine	9-17	ATR serine/threonine kinase	Homo sapiens	0-3
10597277-10	1999	Finally, we find that the kinase activity of ATR in the presence and absence of DNA is suppressed by caffeine, a compound which is known to induce loss of checkpoint control.	Caffeine	101-109	ATR serine/threonine kinase	Homo sapiens	45-48
10531013-0	1999	Caffeine inhibits the checkpoint kinase ATM.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	40-43
10584979-2	1999	In this study, a potential inhibitory effect of omeprazole on caffeine metabolism, a validated CYP1A2 marker, was examined.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	95-101
10584979-7	1999	RESULTS: In vivo, non-parametric point estimates (90% confidence intervals) for the ratios of caffeine pharmacokinetics with/without co-administration of the 40 mg omeprazole dose were: AUC 1.08 (1.04 - 1.13), MRT 1.09 (0.99 - 1.19), and plasma ratio of paraxanthine/caffeine 6 h post-dose 0.91 (0.80 - 1.00).	Caffeine	94-102	serine protease 12	Homo sapiens	210-215
10584979-8	1999	Inhibition of caffeine N3-demethylation by omeprazole was slightly more pronounced in PM than in EM of CYP2C19.	Caffeine	14-22	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	103-110
10537077-3	1999	However, we have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), bradykinin, and angiotensin II release Ca2+ from caffeine/ryanodine-sensitive stores, although they cause a concomitant increase of intracellular IP3.	Caffeine	146-154	adenylate cyclase activating polypeptide 1	Bos taurus	37-87
10534572-9	1999	Furthermore, down-regulation of cyclin B and cdk1 was observed in Taxol and Caffeine treated HPAC cells.	Caffeine	76-84	cyclin dependent kinase 1	Homo sapiens	45-49
10534572-13	1999	The up-regulation of p21WAF1 and down-regulation of cyclin B and cdk1 suggest their possible roles in G2/M cell cycle arrest caused by both Taxol and Caffeine as reported earlier.	Caffeine	150-158	cyclin dependent kinase 1	Homo sapiens	65-69
10656099-15	1999	Caffeine, other coffee compounds or other factors with which coffee drinking is associated may modulate K-ras activation.	Caffeine	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	104-109
10537077-3	1999	However, we have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), bradykinin, and angiotensin II release Ca2+ from caffeine/ryanodine-sensitive stores, although they cause a concomitant increase of intracellular IP3.	Caffeine	146-154	adenylate cyclase activating polypeptide 1	Bos taurus	89-94
10537077-3	1999	However, we have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), bradykinin, and angiotensin II release Ca2+ from caffeine/ryanodine-sensitive stores, although they cause a concomitant increase of intracellular IP3.	Caffeine	146-154	kininogen 1	Bos taurus	97-107
10537077-12	1999	These results suggest that PGE2, acting on EP1-like receptors, induces Ca2+ release from ryanodine/caffeine-sensitive stores through a mechanism independent of IP3 and cAMP and that PGE2 may share the same mechanism with PACAP and the other peptide ligands in causing Ca2+ release in bovine adrenal medullary cells.	Caffeine	99-107	prostaglandin E receptor 1	Bos taurus	43-46
10529377-3	1999	325, 423, 1997) that the fatty acyl CoA ester palmitoyl CoA (PCoA) complexed with a molar excess of its cytosolic binding protein (ACBP) causes a discrete Ca(2+) efflux or allows Ca(2+) release by suboptimal caffeine concentrations, in the Ca(2+)-preloaded terminal cisternae fraction (TC) from rabbit skeletal muscle, by activating ryanodine receptor Ca(2+) release channels (RyRC).	Caffeine	208-216	acyl-CoA-binding protein	Oryctolagus cuniculus	131-135
10531013-8	1999	We report that the radiation-induced activation of the kinase Cds1 [4] (also known as Chk2 [5]) is inhibited by caffeine in vivo and that ATM kinase activity is directly inhibited by caffeine in vitro.	Caffeine	112-120	CDP-diacylglycerol synthase 1	Homo sapiens	62-66
10531013-8	1999	We report that the radiation-induced activation of the kinase Cds1 [4] (also known as Chk2 [5]) is inhibited by caffeine in vivo and that ATM kinase activity is directly inhibited by caffeine in vitro.	Caffeine	112-120	checkpoint kinase 2	Homo sapiens	86-90
10531013-8	1999	We report that the radiation-induced activation of the kinase Cds1 [4] (also known as Chk2 [5]) is inhibited by caffeine in vivo and that ATM kinase activity is directly inhibited by caffeine in vitro.	Caffeine	183-191	CDP-diacylglycerol synthase 1	Homo sapiens	62-66
10531013-8	1999	We report that the radiation-induced activation of the kinase Cds1 [4] (also known as Chk2 [5]) is inhibited by caffeine in vivo and that ATM kinase activity is directly inhibited by caffeine in vitro.	Caffeine	183-191	checkpoint kinase 2	Homo sapiens	86-90
10531013-8	1999	We report that the radiation-induced activation of the kinase Cds1 [4] (also known as Chk2 [5]) is inhibited by caffeine in vivo and that ATM kinase activity is directly inhibited by caffeine in vitro.	Caffeine	183-191	ATM serine/threonine kinase	Homo sapiens	138-141
10531013-9	1999	Inhibition of ATM provides a molecular explanation of the attenuation of DNA-damage checkpoint responses and for the increased radiosensitivity of caffeine-treated cells [6] [7] [8].	Caffeine	147-155	ATM serine/threonine kinase	Homo sapiens	14-17
10503909-6	1999	Caffeine at 1000 and 500 ppm in the drinking water for 2 weeks significantly increased levels of CYP1A2.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	97-103
10546928-0	1999	Flavin monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism.	Caffeine	144-152	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	24-28
10546928-3	1999	We therefore wanted to analyze population frequencies and allelic linkage of FMO3 mutations and their functional effect on the metabolism of clozapine and caffeine.	Caffeine	155-163	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	77-81
10501214-2	1999	In contrast with these results, endogenous nitric oxide generated by the Ca2+-mobilizing agent caffeine was found to increase hydroperoxide toxicity.	Caffeine	95-103	carbonic anhydrase 2	Homo sapiens	73-76
10501214-4	1999	Rather, nitric oxide was found to promote the caffeine-mediated release of Ca2+ from ryanodine-sensitive Ca2+ stores via a cyclic GMP-independent mechanism.	Caffeine	46-54	carbonic anhydrase 2	Homo sapiens	75-78
10501214-4	1999	Rather, nitric oxide was found to promote the caffeine-mediated release of Ca2+ from ryanodine-sensitive Ca2+ stores via a cyclic GMP-independent mechanism.	Caffeine	46-54	carbonic anhydrase 2	Homo sapiens	105-108
10501214-4	1999	Rather, nitric oxide was found to promote the caffeine-mediated release of Ca2+ from ryanodine-sensitive Ca2+ stores via a cyclic GMP-independent mechanism.	Caffeine	46-54	5'-nucleotidase, cytosolic II	Homo sapiens	130-133
10501214-5	1999	Release of the cation from ryanodine-sensitive Ca2+ stores was causally linked with the caffeine/nitric oxide-mediated enhancement of tert-butylhydroperoxide toxicity.	Caffeine	88-96	carbonic anhydrase 2	Homo sapiens	47-50
10473562-10	1999	These results suggest that Ca(2+) and caffeine activation sites also involve COOH-terminal sequences in RyR1 and RyR2.	Caffeine	38-46	ryanodine receptor 1	Oryctolagus cuniculus	104-108
10473562-10	1999	These results suggest that Ca(2+) and caffeine activation sites also involve COOH-terminal sequences in RyR1 and RyR2.	Caffeine	38-46	ryanodine receptor 2	Oryctolagus cuniculus	113-117
10485486-3	1999	The similarity of these checkpoint defects to those seen in ataxia-telangiectasia (A-T) suggested that caffeine might inhibit one or more components in an A-T mutated (ATM)-dependent checkpoint pathway in DNA-damaged cells.	Caffeine	103-111	ATM serine/threonine kinase	Homo sapiens	168-171
10485486-4	1999	We now show that caffeine inhibits the catalytic activity of both ATM and the related kinase, ATM and Rad3-related (ATR), at drug concentrations similar to those that induce radiosensitization.	Caffeine	17-25	ATM serine/threonine kinase	Homo sapiens	66-69
10493909-2	1999	Ca(2+) imaging was used to show caffeine-, carbachol- and thapsigargin-induced Ca(2+) release in HEK-293 cells transfected with ryanodine receptor (RyR) cDNA, but only carbachol- and thapsigargin-induced Ca(2+) release in untransfected HEK-293 cells.	Caffeine	32-40	ryanodine receptor 1	Homo sapiens	128-146
10493909-2	1999	Ca(2+) imaging was used to show caffeine-, carbachol- and thapsigargin-induced Ca(2+) release in HEK-293 cells transfected with ryanodine receptor (RyR) cDNA, but only carbachol- and thapsigargin-induced Ca(2+) release in untransfected HEK-293 cells.	Caffeine	32-40	ryanodine receptor 1	Homo sapiens	148-151
10516641-0	1999	Novel antimigraineur dotarizine releases Ca2+ from caffeine-sensitive Ca2+ stores of chromaffin cells.	Caffeine	51-59	carbonic anhydrase 2	Bos taurus	41-44
10516641-0	1999	Novel antimigraineur dotarizine releases Ca2+ from caffeine-sensitive Ca2+ stores of chromaffin cells.	Caffeine	51-59	carbonic anhydrase 2	Bos taurus	70-73
10516641-8	1999	All three compounds suppressed the transient [Ca2+]c rises induced by caffeine (10 mM, 10 s); blockade induced by thapsigargin was irreversible and that induced by CPA and dotarizine was reversible.	Caffeine	70-78	carbonic anhydrase 2	Bos taurus	46-49
10514564-10	1999	Multicopy PRS3 rescued the caffeine sensitivity of this mpk1 allele.	Caffeine	27-35	ribose phosphate diphosphokinase subunit PRS3	Saccharomyces cerevisiae S288C	10-14
10514564-10	1999	Multicopy PRS3 rescued the caffeine sensitivity of this mpk1 allele.	Caffeine	27-35	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	56-60
10465751-8	1999	The low caffeine sensitivity of RyR type 3-null cells is entirely consistent with observations by other investigators.	Caffeine	8-16	ryanodine receptor 1, skeletal muscle	Mus musculus	32-35
10485486-0	1999	Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.	Caffeine	75-83	ATM serine/threonine kinase	Homo sapiens	14-17
10485486-0	1999	Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.	Caffeine	75-83	ATR serine/threonine kinase	Homo sapiens	22-25
10485486-3	1999	The similarity of these checkpoint defects to those seen in ataxia-telangiectasia (A-T) suggested that caffeine might inhibit one or more components in an A-T mutated (ATM)-dependent checkpoint pathway in DNA-damaged cells.	Caffeine	103-111	ATM serine/threonine kinase	Homo sapiens	155-166
10485486-4	1999	We now show that caffeine inhibits the catalytic activity of both ATM and the related kinase, ATM and Rad3-related (ATR), at drug concentrations similar to those that induce radiosensitization.	Caffeine	17-25	ATM serine/threonine kinase	Homo sapiens	94-97
10485486-4	1999	We now show that caffeine inhibits the catalytic activity of both ATM and the related kinase, ATM and Rad3-related (ATR), at drug concentrations similar to those that induce radiosensitization.	Caffeine	17-25	ATR serine/threonine kinase	Homo sapiens	116-119
10485486-5	1999	Moreover, like ATM-deficient cells, caffeine-treated A549 lung carcinoma cells irradiated in G2 fail to arrest progression into mitosis, and S-phase-irradiated cells exhibit radioresistant DNA synthesis.	Caffeine	36-44	ATM serine/threonine kinase	Homo sapiens	15-18
10485486-6	1999	Similar concentrations of caffeine also inhibit gamma- and UV radiation-induced phosphorylation of p53 on Ser15, a modification that may be directly mediated by the ATM and ATR kinases.	Caffeine	26-34	tumor protein p53	Homo sapiens	99-102
10485486-6	1999	Similar concentrations of caffeine also inhibit gamma- and UV radiation-induced phosphorylation of p53 on Ser15, a modification that may be directly mediated by the ATM and ATR kinases.	Caffeine	26-34	ATM serine/threonine kinase	Homo sapiens	165-168
10485486-6	1999	Similar concentrations of caffeine also inhibit gamma- and UV radiation-induced phosphorylation of p53 on Ser15, a modification that may be directly mediated by the ATM and ATR kinases.	Caffeine	26-34	ATR serine/threonine kinase	Homo sapiens	173-176
10485486-7	1999	DNA-dependent protein kinase, another ATM-related protein involved in DNA damage repair, was resistant to the inhibitory effects of caffeine.	Caffeine	132-140	ATM serine/threonine kinase	Homo sapiens	38-41
10485486-8	1999	Likewise, the catalytic activity of the G2 checkpoint kinase, hChk1, was only marginally suppressed by caffeine but was inhibited potently by the structurally distinct radiosensitizer, UCN-01.	Caffeine	103-111	checkpoint kinase 1	Homo sapiens	62-67
10503909-7	1999	Ten weeks concurrent administration of caffeine (1000 ppm) and PhIP (400 ppm) resulted in significant increase of colon ACFs and CYP1A2 expression.	Caffeine	39-47	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	129-135
10485486-9	1999	These data suggest that the radiosensitizing effects of caffeine are related to inhibition of the protein kinase activities of ATM and ATR and that both proteins are relevant targets for the development of novel anticancer agents.	Caffeine	56-64	ATM serine/threonine kinase	Homo sapiens	127-130
10485486-9	1999	These data suggest that the radiosensitizing effects of caffeine are related to inhibition of the protein kinase activities of ATM and ATR and that both proteins are relevant targets for the development of novel anticancer agents.	Caffeine	56-64	ATR serine/threonine kinase	Homo sapiens	135-138
10503909-9	1999	However, a non-carcinogen, caffeine, enhanced PhIP colon carcinogenesis, possibly due to induction of CYP1A2.	Caffeine	27-35	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	102-108
10744128-8	1999	The NAT2 phenotype was analyzed by the caffeine assay.	Caffeine	39-47	N-acetyltransferase 2	Homo sapiens	4-8
10510174-0	1999	Caffeine-mediated induction of c-fos, zif-268 and arc expression through A1 receptors in the striatum: different interactions with the dopaminergic system.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
10510174-0	1999	Caffeine-mediated induction of c-fos, zif-268 and arc expression through A1 receptors in the striatum: different interactions with the dopaminergic system.	Caffeine	0-8	early growth response 1	Homo sapiens	38-45
10510174-3	1999	Caffeine and DPCPX induced c-fos, zif-268 and arc expression, both at mRNA and protein levels, in large proportions of striatonigral and striatopallidal neurons.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
10510174-3	1999	Caffeine and DPCPX induced c-fos, zif-268 and arc expression, both at mRNA and protein levels, in large proportions of striatonigral and striatopallidal neurons.	Caffeine	0-8	early growth response 1	Homo sapiens	34-41
10471985-1	1999	This study was conducted to investigate the effect of therapeutic estrogen on cytochrome P450 1A2-mediated metabolism in postmenopausal women using caffeine as a model substrate.	Caffeine	148-156	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-97
10471985-6	1999	Consistent with previous results found in younger women, these results indicate that exogenous estrogen in older women may inhibit CYP1A2-mediated caffeine metabolism.	Caffeine	147-155	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	131-137
10535712-8	1999	All cells that responded to 40 mM caffeine responded to 10 nM GHRH.	Caffeine	34-42	growth hormone releasing hormone	Rattus norvegicus	62-66
10444642-11	1999	Time to fatigue (T(lim)) increased by 25.80 +/- 16.06% after caffeine administration (P &lt; 0.05).	Caffeine	61-69	PDZ and LIM domain 5	Homo sapiens	19-22
10428760-11	1999	Caffeine, which abrogates the G2 checkpoint by preventing p34(cdc2) phosphorylation, reduced the accumulation in G2 when added to cultures containing cells on transit to G2, but was ineffective in cells arrested at G2 by sustained cholesterol starvation.	Caffeine	0-8	alpha and gamma adaptin binding protein	Homo sapiens	58-61
10428760-11	1999	Caffeine, which abrogates the G2 checkpoint by preventing p34(cdc2) phosphorylation, reduced the accumulation in G2 when added to cultures containing cells on transit to G2, but was ineffective in cells arrested at G2 by sustained cholesterol starvation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	62-66
10467957-11	1999	Caffeine decreased ibuprofen-induced gastric myeloperoxidase activity in a dose-dependent manner, with an ED50 of 9.1 mg kg(-1).	Caffeine	0-8	myeloperoxidase	Rattus norvegicus	45-60
10417723-6	1999	Modification of eIF4E was mimicked by treatment with caffeine under aerobic conditions and blocked by treatment with ruthenium red under O2 deprivation, implicating Ca2+ as a second messenger in eIF4E modification.	Caffeine	53-61	eukaryotic translation initiation factor 4E-1	Zea mays	16-21
10405004-10	1999	Strong and early G1 arrest was observed in the treatment with LDRI + caffeine at 41 degrees C. The amount of HSP72/73 in the combination of LDRI with caffeine at 41 degrees C was less than that at 41 degrees C alone.	Caffeine	69-77	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-114
10358090-6	1999	In planar lipid bilayers, RyR3 displayed cation channel activity that was modulated by several ligands including Ca2+, Mg2+, caffeine, and ATP, which is consistent with [3H]ryanodine binding activity.	Caffeine	125-133	ryanodine receptor 3	Oryctolagus cuniculus	26-30
10381350-5	1999	The sPLA2-induced [Ca2+]c peak was sensitive to Bordetella pertussis toxin and inhibited by caffeine, suggesting its mediation by inositol 1,4,5-trisphosphate (IP3).	Caffeine	92-100	phospholipase A2 group IIA	Homo sapiens	4-9
10405004-10	1999	Strong and early G1 arrest was observed in the treatment with LDRI + caffeine at 41 degrees C. The amount of HSP72/73 in the combination of LDRI with caffeine at 41 degrees C was less than that at 41 degrees C alone.	Caffeine	150-158	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-114
10341236-4	1999	A low concentration of caffeine enhanced Ca2+ transient amplitude, whereas a higher concentration reduced it.	Caffeine	23-31	carbonic anhydrase 2	Homo sapiens	41-44
10341236-6	1999	The enhancement of Ca2+ transients by caffeine was not affected by the L-type channel blocker nifedipine, the phosphodiesterase inhibitor IBMX, the adenylyl cyclase activator forskolin, or the PKA antagonist H-89.	Caffeine	38-46	carbonic anhydrase 2	Homo sapiens	19-22
10417666-6	1999	Caffeine (10 mmol/l) activated similar [Ca2+]i peaks in control and LGMD2C myotubes but induced a biphasic response in LGMD2C in four out of 12 myotubes and only a monophasic response in control myotubes.	Caffeine	0-8	sarcoglycan gamma	Homo sapiens	119-125
10368407-3	1999	The transient [Ca2+]i rise was independent of the membrane potential and was blocked when caffeine was added to the perfusing solution.	Caffeine	90-98	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	15-18
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Caffeine	90-98	cyclin dependent kinase 1	Homo sapiens	229-233
10417666-6	1999	Caffeine (10 mmol/l) activated similar [Ca2+]i peaks in control and LGMD2C myotubes but induced a biphasic response in LGMD2C in four out of 12 myotubes and only a monophasic response in control myotubes.	Caffeine	0-8	sarcoglycan gamma	Homo sapiens	68-74
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Caffeine	90-98	alpha and gamma adaptin binding protein	Homo sapiens	234-237
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Caffeine	322-330	cyclin dependent kinase 1	Homo sapiens	229-233
10234030-2	1999	Acute intraperitoneal injections of caffeine (7.5 mg/kg) increased locomotion and NGFI-A mRNA, a marker of neuronal activity, in the hippocampal area CA1, but decreased NGFI-A mRNA in rostral striatum and nucleus accumbens.	Caffeine	36-44	early growth response 1	Rattus norvegicus	82-88
10234030-2	1999	Acute intraperitoneal injections of caffeine (7.5 mg/kg) increased locomotion and NGFI-A mRNA, a marker of neuronal activity, in the hippocampal area CA1, but decreased NGFI-A mRNA in rostral striatum and nucleus accumbens.	Caffeine	36-44	carbonic anhydrase 1	Rattus norvegicus	150-153
10234030-2	1999	Acute intraperitoneal injections of caffeine (7.5 mg/kg) increased locomotion and NGFI-A mRNA, a marker of neuronal activity, in the hippocampal area CA1, but decreased NGFI-A mRNA in rostral striatum and nucleus accumbens.	Caffeine	36-44	early growth response 1	Rattus norvegicus	169-175
10234030-3	1999	Rats that received caffeine (0.3 gm/l) in their drinking water for 14 d developed tolerance to the stimulatory effect of a challenge with caffeine (7.5 mg/kg) and responded with a less pronounced decrease of NGFI-A mRNA in rostral striatum and nucleus accumbens.	Caffeine	19-27	early growth response 1	Rattus norvegicus	208-214
10234030-6	1999	Caffeine-tolerant animals had downregulated levels of adenosine A2A receptors and the corresponding mRNA in rostral parts of striatum, but an increased expression of adenosine A1 receptor mRNA in the lateral amygdala.	Caffeine	0-8	adenosine A1 receptor	Rattus norvegicus	166-187
10318807-5	1999	Activation of this complex was correlated with the caffeine-induced release from the UV-induced G2 delay and a decrease in the level of p16 bound to Cdk4.	Caffeine	51-59	cyclin dependent kinase inhibitor 2A	Homo sapiens	136-139
10330030-3	1999	Caffeine (5 mM), ryanodine (0.1-30 microM), and 4-chloro-3-ethylphenol (0.1-0.3 mM), all of which trigger Ca2+-induced Ca2+ release, evoked Ca2+ transients and membrane currents but not contractions.	Caffeine	0-8	carbonic anhydrase 2	Canis lupus familiaris	106-109
10318807-5	1999	Activation of this complex was correlated with the caffeine-induced release from the UV-induced G2 delay and a decrease in the level of p16 bound to Cdk4.	Caffeine	51-59	cyclin dependent kinase 4	Homo sapiens	149-153
10319776-0	1999	ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine.	Caffeine	73-81	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-3
10319776-11	1999	In rat muscle, ATX II increased the magnitude of contracture to caffeine (2 mM) and decreased the time to produce a 1-g contracture to ryanodine (1 microM).	Caffeine	64-72	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	15-18
10224318-8	1999	CYP1A2 activity was estimated from the urinary excretion of metabolites of dietary caffeine.	Caffeine	83-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
10609321-0	1999	[Effect of some antioxidants and caffeine on xanthine dehydrogenase activity in rat liver in vitro].	Caffeine	33-41	xanthine dehydrogenase	Rattus norvegicus	45-67
10609321-1	1999	The regulation of xanthine dehydrogenase activity by reductors-antioxidants (ascorbic acid, glutatione-SH, gentathione dithiothreitol, cysteine and hydrocortisone) and caffeine was investigated in the purified enzymatic preparation in vitro.	Caffeine	168-176	xanthine dehydrogenase	Rattus norvegicus	18-40
10087335-14	1999	The transient response to Epo was dependent on external Ca2+ and remained even after depletion of internal Ca2+ stores by caffeine or thapsigargin.	Caffeine	122-130	erythropoietin	Homo sapiens	26-29
10087341-11	1999	Caffeine was used to release Ca2+ from the sarcoplasmic reticulum (SR).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	29-32
10087341-12	1999	There was a significant reduction in the ratio of electrically stimulated : caffeine-induced Ca2+ transients in taxol-treated cells.	Caffeine	76-84	carbonic anhydrase 2	Rattus norvegicus	93-96
10233204-0	1999	Dietary caffeine as a probe agent for assessment of cytochrome P4501A2 activity in random urine samples.	Caffeine	8-16	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-70
10198326-4	1999	ACh as well as caffeine caused transient increases in KCa channel activity, and the effects of ACh persisted in Ca2+-free solution, indicating that Ca2+ release from stores contributed to channel activation.	Caffeine	15-23	casein kappa	Homo sapiens	54-57
10096910-3	1999	This study examines the relationship between cross-bridge cycling and thin filament activation by comparing the results of kinetic experiments using the Ca2+ sensitizers caffeine and bepridil.	Caffeine	170-178	carbonic anhydrase 2	Rattus norvegicus	153-156
10233204-1	1999	AIMS: To validate the use of randomly collected urine samples for assessment of cytochrome P4501A2 (CYP1A2) activity based on dietary caffeine (caffeine metabolic ratio, MRcaff ), and to relate the MRcaff to caffeine intake and smoking habits in a larger group of individuals.	Caffeine	134-142	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-98
10233204-1	1999	AIMS: To validate the use of randomly collected urine samples for assessment of cytochrome P4501A2 (CYP1A2) activity based on dietary caffeine (caffeine metabolic ratio, MRcaff ), and to relate the MRcaff to caffeine intake and smoking habits in a larger group of individuals.	Caffeine	134-142	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
10233204-1	1999	AIMS: To validate the use of randomly collected urine samples for assessment of cytochrome P4501A2 (CYP1A2) activity based on dietary caffeine (caffeine metabolic ratio, MRcaff ), and to relate the MRcaff to caffeine intake and smoking habits in a larger group of individuals.	Caffeine	144-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
10233204-1	1999	AIMS: To validate the use of randomly collected urine samples for assessment of cytochrome P4501A2 (CYP1A2) activity based on dietary caffeine (caffeine metabolic ratio, MRcaff ), and to relate the MRcaff to caffeine intake and smoking habits in a larger group of individuals.	Caffeine	144-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
10223772-2	1999	In this study we investigated the inhibition profiles of CYP1A2 (substrate: caffeine) CYP2D6 (substrate: dextromethorphan), and CYP3A4/5 (substrate: dextrorphan) by cimetidine, ranitidine, and the novel H2-receptor antagonist ebrotidine in human liver microsomes.	Caffeine	76-84	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
10331854-4	1999	RESULTS: Both BL-13 and BL-28 cells (each expressing p53 with a wild-type sequence) fail to arrest at the G2 checkpoint after radiation, but nevertheless caffeine did induce radiosensitization.	Caffeine	154-162	tumor protein p53	Homo sapiens	53-56
10103113-3	1999	We report that in rat hippocampal neuronal cultures, GP120 induces a dramatic and persistent increase in [Ca2+]i which is prevented by drugs that either deplete (caffeine, carbachol, thapsigargin) or block (dantrolene) Ca2+ release from intracellular stores.	Caffeine	162-170	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
10331854-5	1999	In contrast, in BL-17/2 cells (expressing p53 with a point mutation in codon 280), caffeine treatment abrogated the radiation-induced G2 arrest but was not accompanied by radiosensitization.	Caffeine	83-91	tumor protein p53	Homo sapiens	42-45
10197295-1	1999	Measurement of salivary clearance and urinary metabolites of caffeine is an excellent noninvasive tool for assessing liver function, particularly the activity of cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT), and xanthine oxidase (XO).	Caffeine	61-69	bromodomain containing 2	Homo sapiens	212-215
10101295-5	1999	The point mutation caused a significant decrease of CYP1A2 activity measured by the rate of caffeine 3-demethylation in Japanese smokers (p<0.05).	Caffeine	92-100	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58
10202397-3	1999	The inhibitory effect of green tea has been attributed to its major polyphenolic compound, epigallocatechin gallate (EGCG), and, to a lesser extent, to caffeine.	Caffeine	152-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	31-34
10376760-0	1999	Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.	Caffeine	94-102	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-37
10376760-4	1999	Overall geometric mean (geometric SD) caffeine clearance was 1.34 ml min(-1) kg b.w.	Caffeine	38-46	CD59 molecule (CD59 blood group)	Homo sapiens	69-75
10097181-5	1999	The response of the mutant RyR1 Ca2+ channel to the agonists halothane and caffeine in a Ca2+ photometry assay was completely abolished.	Caffeine	75-83	ryanodine receptor 1	Homo sapiens	27-30
10217339-2	1999	CYP1A2, the major cytochrome P450 isoform involved in the metabolism of caffeine, has also been implicated in the formation of N-hydroxymexiletine, the major metabolite of mexiletine.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
10097181-6	1999	Coexpression of normal and mutant RYR1 cDNAs in a 1:1 ratio, however, produced RyR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca2+ release were reduced by 67%.	Caffeine	119-127	ryanodine receptor 1	Homo sapiens	34-38
10069669-1	1999	Our previous studies supported the hypothesis that prolonged administration of caffeine to animals with high-renin hypertension causes progressive deterioration of renal function.	Caffeine	79-87	renin	Rattus norvegicus	109-114
10073324-0	1999	Effect of venlafaxine on CYP1A2-dependent pharmacokinetics and metabolism of caffeine.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
10066929-4	1999	Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	49-52
10066929-4	1999	Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	76-79
10066929-4	1999	Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	76-79
10066929-4	1999	Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	76-79
10066929-4	1999	Application of caffeine produced an increase in [Ca2+]i and also increased [Ca2+]m. The increase in [Ca2+]m occurred after the increase in [Ca2+]i, and remained elevated for a considerable time after [Ca2+]i had returned to resting values.	Caffeine	15-23	carbonic anhydrase 2	Rattus norvegicus	76-79
10066929-6	1999	The protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP), which causes the mitochondrial membrane potential to collapse, markedly attenuated the increase in [Ca2+]m following caffeine application and also increased the half-time for recovery of [Ca2+]i to resting values.	Caffeine	195-203	carbonic anhydrase 2	Rattus norvegicus	178-181
10066929-6	1999	The protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP), which causes the mitochondrial membrane potential to collapse, markedly attenuated the increase in [Ca2+]m following caffeine application and also increased the half-time for recovery of [Ca2+]i to resting values.	Caffeine	195-203	carbonic anhydrase 2	Rattus norvegicus	266-269
10100864-0	1999	Caffeine releases a glucose-primed endoplasmic reticulum Ca2+ pool in the insulin secreting cell line INS-1.	Caffeine	0-8	insulin 1	Rattus norvegicus	102-107
10100864-1	1999	Caffeine mobilized an intracellular Ca2+ pool in intact fura-2-loaded INS-1 cells in suspension exposed to high (16 mM) [glucose], while a minor effect was observed with low (2 mM) [glucose].	Caffeine	0-8	insulin 1	Rattus norvegicus	70-75
10100864-6	1999	It was concluded that the endoplasmic reticulum of INS-1 cells possesses caffeine-sensitive type 2 ryanodine receptors Ca2+ channels.	Caffeine	73-81	insulin 1	Rattus norvegicus	51-56
10069681-0	1999	Caffeine increases renal renin secretion in a rat model of genetic heart failure.	Caffeine	0-8	renin	Rattus norvegicus	25-30
10069681-1	1999	In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone.	Caffeine	36-44	renin	Rattus norvegicus	68-73
10069681-1	1999	In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone.	Caffeine	36-44	renin	Rattus norvegicus	181-186
10069681-1	1999	In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone.	Caffeine	46-50	renin	Rattus norvegicus	68-73
10069681-7	1999	CAFF increased plasma renin activity (PRA), norepinephrine (NE), and epinephrine (E) levels in all three strains [treatment effect, p&lt;0.001, 2F analysis of variance (ANOVA)], and these effects were greater in hypertensive (SHRs and SHHF) animals as compared with normotensive WKY rats (p&lt;0.015).	Caffeine	0-4	renin	Rattus norvegicus	22-27
10069681-9	1999	However, CAFF treatment significantly increased renal renin secretion (71.1+/-19.2 vs. 9.5+/-5.8 ng Ang I/h/min/kg for caffeine and control group, respectively; p&lt;0.01).	Caffeine	9-13	renin	Rattus norvegicus	54-59
10073324-2	1999	Caffeine is a metabolic probe for the quantitative measurement of CYP1A2 activity in vivo.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
10069681-12	1999	Moreover, this study provides the first evidence that short-term caffeine consumption increases renal renin secretion in heart failure, an effect most likely due to the blockade of intrarenal adenosine receptors.	Caffeine	65-73	renin	Rattus norvegicus	102-107
10069669-12	1999	These data support our hypothesis that prolonged consumption of caffeine has adverse effects on renal function, in high-renin hypertension.	Caffeine	64-72	renin	Rattus norvegicus	120-125
9873004-3	1999	Cells expressing homotetrameric CCD or MH mutant RyR1 exhibited lower maximal peak amplitudes of caffeine-induced Ca2+ release than cells expressing wild type RyR1, suggesting that MH and CCD mutants might be "leaky."	Caffeine	97-105	ryanodine receptor 1	Homo sapiens	49-53
10229929-5	1999	It is suggested that thioridazine alone or in combination with caffeine may exert its synergistic effect on melphalan cytotoxicity to cultured human lymphocytes not only indirectly, i.e. as a strong calmodulin inhibitor by facilitating the intracellular retention of melphalan, but also directly by reaction with nucleic acids and by causing scissions in and damage to them.	Caffeine	63-71	calmodulin 1	Homo sapiens	199-209
10193789-2	1999	The effects of Ca2+, ATP and caffeine on the gating of lobster skeletal muscle ryanodine receptors (RyR) was investigated after reconstitution of the channels into planar phospholipid bilayers and by using [3H]-ryanodine binding studies.	Caffeine	29-37	ryanodine receptor 1	Homo sapiens	100-103
10193789-14	1999	Caffeine, often used as a tool to identify the presence of RyR channels, is relatively ineffective and cannot increase Po above the level that can be attained with Ca2+ alone.	Caffeine	0-8	ryanodine receptor 1	Homo sapiens	59-62
10193789-18	1999	By studying the mechanisms involved in the activation of the lobster RyR we have demonstrated that the channel responds in a unique manner to Ca2+ and to caffeine.	Caffeine	154-162	ryanodine receptor 1	Homo sapiens	69-72
10326681-13	1999	These data provide evidence for a direct interaction of caffeine but not of adenophostin A or cyclic ADP-ribose with the adenine-nucleotide binding sites of the IP3R.	Caffeine	56-64	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	161-165
9873004-4	1999	In cells expressing homotetrameric wild type or mutant RyR1, the amplitude of 10 mM caffeine-induced Ca2+ release was correlated significantly with the amplitude of carbachol- or thapsigargin-induced Ca2+ release, indicating that maximal drug-induced Ca2+ release depends on the size of the endoplasmic reticulum Ca2+ store.	Caffeine	84-92	ryanodine receptor 1	Homo sapiens	55-59
9873004-6	1999	When heterotetrameric (1:1) combinations of MH/CCD mutant and wild type RyR1 were expressed together with SERCA1 to enhance Ca2+ reuptake, the amplitude of Ca2+ release in response to low concentrations of caffeine and halothane was higher than that observed in cells expressing wild type RyR1 and SERCA1.	Caffeine	206-214	ryanodine receptor 1	Homo sapiens	72-76
9873004-6	1999	When heterotetrameric (1:1) combinations of MH/CCD mutant and wild type RyR1 were expressed together with SERCA1 to enhance Ca2+ reuptake, the amplitude of Ca2+ release in response to low concentrations of caffeine and halothane was higher than that observed in cells expressing wild type RyR1 and SERCA1.	Caffeine	206-214	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	106-112
10463072-4	1999	The difference among RyR isoforms may not be so great in CICR activity, in other words, in the interaction of RyR isoforms with Ca2+, adenine nucleotides and caffeine.	Caffeine	158-166	ryanodine receptor 1	Homo sapiens	21-24
9873004-7	1999	In Ca2+-free medium, MH/CCD mutants were more sensitive to caffeine than wild type RyR1, indicating that caffeine hypersensitivity observed with a variety of MH/CCD mutant RyR1 proteins is not dependent on extracellular Ca2+ concentration.	Caffeine	105-113	ryanodine receptor 1	Homo sapiens	83-87
9873004-7	1999	In Ca2+-free medium, MH/CCD mutants were more sensitive to caffeine than wild type RyR1, indicating that caffeine hypersensitivity observed with a variety of MH/CCD mutant RyR1 proteins is not dependent on extracellular Ca2+ concentration.	Caffeine	105-113	ryanodine receptor 1	Homo sapiens	172-176
11253312-0	1999	[Phenotyping of cytochrome P-450 1A2 and N-acetyltransferase (NAT2) using the in vivo caffeine test as a tool for determining individual susceptibility to selected xenobiotics].	Caffeine	86-94	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-36
11253312-0	1999	[Phenotyping of cytochrome P-450 1A2 and N-acetyltransferase (NAT2) using the in vivo caffeine test as a tool for determining individual susceptibility to selected xenobiotics].	Caffeine	86-94	N-acetyltransferase 2	Homo sapiens	62-66
11253312-1	1999	An in vivo phenotyping method of CYP1A2 (cytochrome P-450 1A2) and NAT2 (N-acetyltransferase, isoform 2) based on caffeine test (Butler et al.	Caffeine	114-122	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
11253312-1	1999	An in vivo phenotyping method of CYP1A2 (cytochrome P-450 1A2) and NAT2 (N-acetyltransferase, isoform 2) based on caffeine test (Butler et al.	Caffeine	114-122	N-acetyltransferase 2	Homo sapiens	67-71
10463072-4	1999	The difference among RyR isoforms may not be so great in CICR activity, in other words, in the interaction of RyR isoforms with Ca2+, adenine nucleotides and caffeine.	Caffeine	158-166	ryanodine receptor 1	Homo sapiens	110-113
9887000-4	1999	Preexposure of cells to thapsigargin and caffeine prevented the response to bombesin, indicating activation of inositol 1,4,5-trisphosphate (IP3)-sensitive stores.	Caffeine	41-49	gastrin releasing peptide	Homo sapiens	76-84
9887024-4	1999	Depletion of intracellular Ca2+ stores with caffeine (3 mM) abolished all responses to sympathetic nerve stimulation.	Caffeine	44-52	carbonic anhydrase 2	Homo sapiens	27-30
9872947-8	1999	Moreover, because overexpression of NHP6A can suppress caffeine sensitivity of one of the SWI6 ANK mutants, swi6-405, other SWI6-dependent genes may also be affected by Nhp6A.	Caffeine	55-63	transcriptional regulator SWI6	Saccharomyces cerevisiae S288C	108-112
9887024-6	1999	Caffeine (3 mM), in the presence of the Ca2+-ATPase inhibitor thapsigargin (30 microM), abolished irreversibly the chronotropic and inotropic responses evoked by sympathetic nerve stimulation.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	40-43
10027663-0	1999	Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities.	Caffeine	78-86	N-acetyltransferase 2	Homo sapiens	119-140
10027663-0	1999	Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	145-151
10027663-11	1999	CONCLUSIONS: Several caffeine metabolic ratios are commonly used to express the activities of NAT2, CYP1A2 and XO both in healthy volunteers and in polymedicated patients, although their reliability has not been evaluated thoroughly during concurrent drug administration.	Caffeine	21-29	N-acetyltransferase 2	Homo sapiens	94-98
10027663-11	1999	CONCLUSIONS: Several caffeine metabolic ratios are commonly used to express the activities of NAT2, CYP1A2 and XO both in healthy volunteers and in polymedicated patients, although their reliability has not been evaluated thoroughly during concurrent drug administration.	Caffeine	21-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
10027663-13	1999	It also shows that the determination of CYP1A2 activity with caffeine as a metabolic probe is considerably altered under these conditions.	Caffeine	61-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46
9872947-8	1999	Moreover, because overexpression of NHP6A can suppress caffeine sensitivity of one of the SWI6 ANK mutants, swi6-405, other SWI6-dependent genes may also be affected by Nhp6A.	Caffeine	55-63	high-mobility group nucleosome-binding protein	Saccharomyces cerevisiae S288C	36-41
9872947-8	1999	Moreover, because overexpression of NHP6A can suppress caffeine sensitivity of one of the SWI6 ANK mutants, swi6-405, other SWI6-dependent genes may also be affected by Nhp6A.	Caffeine	55-63	transcriptional regulator SWI6	Saccharomyces cerevisiae S288C	90-94
10493258-16	1999	Currently, caffeine has the best potential for use in epidemiological studies: metabolites of caffeine after coffee consumption are measured as an index of CYP1A2 activity.	Caffeine	11-19	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
10473264-2	1999	Autoradiographic study revealed that the basal uptake of 45Ca2+ into the endoplasmic reticulum and caffeine-induced 45Ca2+ release from the endoplasmic reticulum were normal in the presence of ATP in each ischemic brain region, whereas inositol 1,4,5-trisphosphate receptor-induced 45Ca2+ release from the endoplasmic reticulum was inhibited only in the CA1 region of the hippocampus on the ischemic side.	Caffeine	99-107	carbonic anhydrase 1	Homo sapiens	354-357
10094584-8	1999	Caffeine enhanced noradrenaline-induced lipolysis in fat cells without a concomitant increase in HSL activity and also accelerated the hormone-induced lipolysis in a cell-free system consisting of lipid droplets and HSL, but not in the cell-free system with sonicated lipid droplets and HSL.	Caffeine	0-8	lipase, hormone sensitive	Mus musculus	216-219
10094584-8	1999	Caffeine enhanced noradrenaline-induced lipolysis in fat cells without a concomitant increase in HSL activity and also accelerated the hormone-induced lipolysis in a cell-free system consisting of lipid droplets and HSL, but not in the cell-free system with sonicated lipid droplets and HSL.	Caffeine	0-8	lipase, hormone sensitive	Mus musculus	216-219
10049063-0	1999	DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations.	Caffeine	87-95	tumor protein p53	Homo sapiens	111-114
10049063-1	1999	Caffeine is known to potentiate the cytotoxic effects of DNA damaging agents and increases the sensitivity of p53-deficient cells to X-irradiation (X-IR).	Caffeine	0-8	tumor protein p53	Homo sapiens	110-113
10049063-5	1999	The cell cycle modifications in these cell lines correlated with the increase in radiation-induced p34Cdc2 kinase activity by caffeine.	Caffeine	126-134	cyclin dependent kinase 1	Homo sapiens	99-106
10049063-7	1999	These results suggest that the cytocidal effect of caffeine may need to be verified independently of its cell cycle regulatory activities at least in some cases with p53 mutation.	Caffeine	51-59	tumor protein p53	Homo sapiens	166-169
9892847-12	1999	The cAMP enhancers, caffeine, NaF and forskolin significantly increased the thymulin-stimulated release of GH while trifluoperazine, a protein kinase C inhibitor, had no effect.	Caffeine	20-28	gonadotropin releasing hormone receptor	Rattus norvegicus	107-109
10493258-16	1999	Currently, caffeine has the best potential for use in epidemiological studies: metabolites of caffeine after coffee consumption are measured as an index of CYP1A2 activity.	Caffeine	94-102	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	156-162
9884987-3	1998	The extracellular monoamine level was increased by perfusion with a non-selective adenosine receptor antagonist, caffeine, a selective adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine (CPT), and an antiepileptic drug, carbamazepine, whereas adenosine, a selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine (CCPA) reduced extracellular monoamine levels.	Caffeine	113-121	adenosine A1 receptor	Rattus norvegicus	135-156
11281962-1	1998	The main behavioural features of the adenosine A(2A) receptor knockout mouse include anxiety, aggressiveness in males and a paradoxical response to caffeine.	Caffeine	148-156	adenosine A2a receptor	Mus musculus	37-61
9884987-3	1998	The extracellular monoamine level was increased by perfusion with a non-selective adenosine receptor antagonist, caffeine, a selective adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine (CPT), and an antiepileptic drug, carbamazepine, whereas adenosine, a selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine (CCPA) reduced extracellular monoamine levels.	Caffeine	113-121	adenosine A1 receptor	Rattus norvegicus	284-305
9868741-7	1998	The formation of 1,7-dimethylxanthine was virtually abolished by 10 microM of fluvoxamine, indicating that the N3-demethylation of caffeine is almost exclusively catalysed by CYP1A2.	Caffeine	131-139	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	175-181
9868741-8	1998	The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine.	Caffeine	228-236	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10
9868741-8	1998	The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine.	Caffeine	228-236	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	195-201
9853304-3	1998	NT also increased the tension response to caffeine, another store-Ca2+ releaser.	Caffeine	42-50	neurotensin/neuromedin N	Cavia porcellus	0-2
9802702-0	1998	Immunohistochemical localization of caffeine-induced c-Fos protein expression in the rat brain.	Caffeine	36-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
9802702-8	1998	In contrast, caffeine at 75 mg/kg induced a significant increase compared with the saline condition in the number of Fos-immunoreactive neurons in the majority of structures examined.	Caffeine	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
9769415-23	1998	These results permit a scheme in which caffeine acts directly upon ryanodine receptor (RyR)-Ca2+ release channels whose consequent activation then dissociates them from the tubular dihydropyridine receptor (DHPR) voltage sensors that produce qgamma charge movement, with which they normally are coupled in reciprocal allosteric contact.	Caffeine	39-47	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	181-205
9769415-23	1998	These results permit a scheme in which caffeine acts directly upon ryanodine receptor (RyR)-Ca2+ release channels whose consequent activation then dissociates them from the tubular dihydropyridine receptor (DHPR) voltage sensors that produce qgamma charge movement, with which they normally are coupled in reciprocal allosteric contact.	Caffeine	39-47	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	207-211
9877005-4	1998	Following the substitution of caffeine solution for tap water, behavior was temporarily disrupted as evidenced by decreases in responding and QL values which reached a maximum after 72 h (rate 60% and QL 30% below baseline levels).	Caffeine	30-38	nuclear RNA export factor 1	Rattus norvegicus	52-55
9813294-5	1998	injection of cocaine, amphetamine and caffeine induced hVH-5 mRNA expression within 40 min in the nucleus accumbens (NAc), caudate putamen, frontal cortex and hippocampus, with a maximal effect in the NAc.	Caffeine	38-46	dual specificity phosphatase 8	Homo sapiens	55-60
9771651-5	1998	The tyrosine phosphorylation of p93, p175, and several other sperm proteins was up-regulated in a concentration-dependent manner following treatment of the sperm with dbcAMP, caffeine, or IBMX alone, or with combinations of caffeine and IBMX, respectively, with dbcAMP; the tyrosine phosphorylation of p20 was not correlated with treatment of sperm with cAMP-elevating reagents.	Caffeine	175-183	tubulin polymerization promoting protein family member 3	Homo sapiens	302-305
9744884-0	1998	The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts.	Caffeine	43-51	checkpoint kinase 1 L homeolog	Xenopus laevis	12-16
9873837-0	1998	Caffeine causes glycerophosphorylcholine accumulation through ryanodine-inhibitable increase of cellular calcium and activation of phospholipase A2 in cultured MDCK cells.	Caffeine	0-8	phospholipase A2 group IB	Canis lupus familiaris	131-147
9873837-4	1998	Caffeine stimulated the rate of [14C]choline incorporation into [14C]GPC and PLA2 activity.	Caffeine	0-8	phospholipase A2 group IB	Canis lupus familiaris	77-81
9873837-9	1998	Ryanodine (10 mM) also inhibited the caffeine-induced stimulation of PLA2 activity.	Caffeine	37-45	phospholipase A2 group IB	Canis lupus familiaris	69-73
9873837-10	1998	These findings provide the first evidence that caffeine in MDCK cells causes a ryanodine-inhibitable increase of [Ca2+]i and PLA2 activity, resulting in cellular GPC accumulation.	Caffeine	47-55	phospholipase A2 group IB	Canis lupus familiaris	125-129
9742097-5	1998	Moreover, bypass of this G2 block by caffeine revealed defective chromosome condensation in Ku86-deficient cells.	Caffeine	37-45	X-ray repair cross-complementing protein 5	Cricetulus griseus	92-96
9744884-8	1998	Our results indicate that caffeine disrupts the checkpoint pathway containing Xchk1.	Caffeine	26-34	checkpoint kinase 1 L homeolog	Xenopus laevis	78-83
9744884-6	1998	Xchk1 is highly phosphorylated in the presence of unreplicated or damaged DNA, and this phosphorylation is abolished by caffeine, an agent which attenuates checkpoint control.	Caffeine	120-128	checkpoint kinase 1 L homeolog	Xenopus laevis	0-5
9764962-0	1998	Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer"s disease.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	27-33
9764962-1	1998	AIMS: To study the potential utility of caffeine based probes of CYP1A2 enzyme activity in predicting the pharmokinetics of tacrine in patients with Alzheimer"s disease.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	65-71
9794255-6	1998	However, in the preparations exposed to caffeine, the translocation of PKC occurred only in a Ca2+-dependent subtype.	Caffeine	40-48	proline rich transmembrane protein 2	Homo sapiens	71-74
9794255-7	1998	In addition, the biphasic change in membrane-associated PKC seen in high K+ exposed muscles was absent with caffeine treatment.	Caffeine	108-116	proline rich transmembrane protein 2	Homo sapiens	56-59
9794255-0	1998	Effects of high potassium and caffeine exposure on activities of Ca2+-dependent and Ca2+-independent protein kinase C in frog skeletal muscle.	Caffeine	30-38	proline rich transmembrane protein 2	Homo sapiens	101-117
9818729-11	1998	The cAMP enhancers, caffeine, NaF and forskolin, significantly increased the thymulin-stimulated release of PRL and TSH, while trifluoperazine, a protein kinase C inhibitor, had no effect.	Caffeine	20-28	prolactin	Rattus norvegicus	108-111
9703212-18	1998	The sensitivity of NA- and caffeine-induced contraction to W-7 suggests a role for calcium and its interaction with calmodulin in the response to both agents.	Caffeine	27-35	calmodulin 1	Homo sapiens	116-126
9725998-0	1998	Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein.	Caffeine	35-43	pleckstrin homology domain interacting protein	Homo sapiens	14-18
9729274-7	1998	Utilizing quantitative immunoblotting methods, we found that hippocampal Gialpha1,2 and Gialpha3 subunits were significantly reduced by 20.2% and 11.1%, respectively, in caffeine tolerant/dependent mice (caffeine 125 mg kg-1 day-1 vs. vehicle controls).	Caffeine	170-178	guanine nucleotide binding protein (G protein), alpha inhibiting 1	Mus musculus	73-83
9729274-7	1998	Utilizing quantitative immunoblotting methods, we found that hippocampal Gialpha1,2 and Gialpha3 subunits were significantly reduced by 20.2% and 11.1%, respectively, in caffeine tolerant/dependent mice (caffeine 125 mg kg-1 day-1 vs. vehicle controls).	Caffeine	170-178	guanine nucleotide binding protein (G protein), alpha inhibiting 3	Mus musculus	88-96
9729274-7	1998	Utilizing quantitative immunoblotting methods, we found that hippocampal Gialpha1,2 and Gialpha3 subunits were significantly reduced by 20.2% and 11.1%, respectively, in caffeine tolerant/dependent mice (caffeine 125 mg kg-1 day-1 vs. vehicle controls).	Caffeine	204-212	guanine nucleotide binding protein (G protein), alpha inhibiting 1	Mus musculus	73-83
9729274-7	1998	Utilizing quantitative immunoblotting methods, we found that hippocampal Gialpha1,2 and Gialpha3 subunits were significantly reduced by 20.2% and 11.1%, respectively, in caffeine tolerant/dependent mice (caffeine 125 mg kg-1 day-1 vs. vehicle controls).	Caffeine	204-212	guanine nucleotide binding protein (G protein), alpha inhibiting 3	Mus musculus	88-96
9729274-9	1998	This same caffeine treatment also produced significant decreases in cortical Gsalpha subunits of 14.0%.	Caffeine	10-18	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	77-84
9916262-4	1998	For optimization of CYP1A2 active site structure the models of its complexes with characteristic substrates (caffeine and 7-ethoxyresorufin) were designed.	Caffeine	109-117	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
9693105-3	1998	The present study was to test the hypothesis that the caffeine/Abeta responses were due to interactions with specific subtypes of ryanodine receptors (RyR) using [3H]ryanodine receptor binding, epifluorescence imaging of Ca2+i, immunocytofluorescence, immunoprecipitation and PCR techniques.	Caffeine	54-62	ryanodine receptor 1	Homo sapiens	130-149
9693105-3	1998	The present study was to test the hypothesis that the caffeine/Abeta responses were due to interactions with specific subtypes of ryanodine receptors (RyR) using [3H]ryanodine receptor binding, epifluorescence imaging of Ca2+i, immunocytofluorescence, immunoprecipitation and PCR techniques.	Caffeine	54-62	ryanodine receptor 1	Homo sapiens	151-154
9754926-2	1998	This release was blocked by both 1 mM tetracaine and 30 microM ruthenium red which inhibit the ryanodine receptor or by pre-treatment with 10 mM caffeine which depletes the ryanodine receptor-containing Ca2+ stores.	Caffeine	145-153	carbonic anhydrase 2	Mus musculus	203-206
9725998-5	1998	This led to the study of caffeine, that displayed effective dose-related inhibition of the mutagenicity of PhIP.	Caffeine	25-33	pleckstrin homology domain interacting protein	Homo sapiens	107-111
9572473-4	1998	HSR actively exchanged Ca2+ with the medium through a partially open ryanodine-binding channel (RyR), as evidenced by the rapid attainment of a steady-state gradient between HSR and medium, which was promptly increased by the closure of the channel with ruthenium red (RR) or collapsed by its opening with caffeine.	Caffeine	306-314	ryanodine receptor 1	Homo sapiens	96-99
9867310-3	1998	The main probe drugs include caffeine and theophylline, whose metabolism is catalysed by CYP1A2, tolbutamide, phenytoin and ibuprofen, catalysed by CYP2C9, amitriptyline and nortriptyline, catalysed by CYP2C19, acetaminophen, catalysed by CYP2E1 and lidocaine, midazolam and terfenadine, catalysed by 3A3/4.	Caffeine	29-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	89-95
9867310-3	1998	The main probe drugs include caffeine and theophylline, whose metabolism is catalysed by CYP1A2, tolbutamide, phenytoin and ibuprofen, catalysed by CYP2C9, amitriptyline and nortriptyline, catalysed by CYP2C19, acetaminophen, catalysed by CYP2E1 and lidocaine, midazolam and terfenadine, catalysed by 3A3/4.	Caffeine	29-37	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	148-154
9867310-3	1998	The main probe drugs include caffeine and theophylline, whose metabolism is catalysed by CYP1A2, tolbutamide, phenytoin and ibuprofen, catalysed by CYP2C9, amitriptyline and nortriptyline, catalysed by CYP2C19, acetaminophen, catalysed by CYP2E1 and lidocaine, midazolam and terfenadine, catalysed by 3A3/4.	Caffeine	29-37	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	202-209
9867310-3	1998	The main probe drugs include caffeine and theophylline, whose metabolism is catalysed by CYP1A2, tolbutamide, phenytoin and ibuprofen, catalysed by CYP2C9, amitriptyline and nortriptyline, catalysed by CYP2C19, acetaminophen, catalysed by CYP2E1 and lidocaine, midazolam and terfenadine, catalysed by 3A3/4.	Caffeine	29-37	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	239-245
9665131-4	1998	In ventral midbrain dopamine neurons, activation of metabotropic glutamate receptors (mGluR1) mobilized calcium from caffeine/ryanodine-sensitive stores and increased an apamin-sensitive potassium conductance.	Caffeine	117-125	glutamate metabotropic receptor 1	Homo sapiens	86-92
10030456-4	1998	The specificity of the induction by 4-methylpyrazole and of the inhibition by diallyl sulfide for CYP2E1 was determined using the [14C]caffeine (CYP1A2), [14C]aminopyrine (CYP2C11), and [14C]erythromycin (CYP3A2) breath tests.	Caffeine	135-143	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	98-104
9787829-7	1998	Caffeine and forskolin were also effective relaxants of contractions evoked by ET-1 in both veins, suggesting relaxation by elevated levels of cAMP.	Caffeine	0-8	endothelin 1	Bos taurus	79-83
9710300-5	1998	Caffeine alone elevated ACTH and cortisol in both groups, with more immediate responses in the high risk group.	Caffeine	0-8	proopiomelanocortin	Homo sapiens	24-28
9710300-6	1998	Both groups showed significant ACTH and cortisol responses to caffeine plus tasks, with the high risk group showing more persistent elevations.	Caffeine	62-70	proopiomelanocortin	Homo sapiens	31-35
9710300-7	1998	The high risk group also showed the highest levels of ACTH and cortisol after caffeine plus tasks.	Caffeine	78-86	proopiomelanocortin	Homo sapiens	54-58
9710300-8	1998	CONCLUSIONS: These findings demonstrate for the first time the combined effects of caffeine plus stress on ACTH and demonstrate greater corticosteroid effects in hypertension-prone men.	Caffeine	83-91	proopiomelanocortin	Homo sapiens	107-111
9855065-4	1998	Cytochrome P-450 1A2 activity was determined on the basis of an in vivo caffeine metabolism study.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-20
9690697-1	1998	Both clozapine (CLZ) and caffeine are CYP1A2 substrates.	Caffeine	25-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44
9690697-5	1998	The CYP1A2 activity was determined by means of a urinary caffeine test.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
9572473-10	1998	Compared to the large calcium pool, the sensitivity of both RyR channel and SERCA to extravesicular free Ca2+ concentration as well as to caffeine and RR was markedly enhanced.	Caffeine	138-146	ryanodine receptor 1	Homo sapiens	60-63
9831966-5	1998	One type consists of non-genetic P450 function tests (CYP1A2, 2A6, 2C9/10, 2E1 and 3A3/4), and probe drugs include caffeine, catalysed by CYP1A2, coumarin by CYP2A6, phenytoin by CYP2C6, chlorzoxazone by CYP2E1, and nifedipine, erythromycin and lidocaine by CYP3A3/4.	Caffeine	115-123	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	138-144
9582266-6	1998	Moreover, we show that expression of the NES-disrupted cyclin B1 or LMB treatment of the cells is able to override the DNA damage-induced G2 checkpoint when combined with caffeine treatment.	Caffeine	171-179	cyclin B1	Homo sapiens	55-64
9651540-2	1998	An analysis at the network and membrane level has provided evidence that antagonistic interactions between adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptors in the ventral and dorsal striatum are at least in part responsible for the motor stimulant effects of adenosine receptor antagonists like caffeine and for the motor depressant actions of adenosine receptor agonists.	Caffeine	311-319	immunoglobulin kappa variable 2D-30	Homo sapiens	147-161
10076527-1	1998	The effects of flavonoids on caffeine N3-demethylation, a marker activity of CYP1A2, in human liver microsomes were investigated to elucidate the inhibition mechanism and the structure-activity relationship.	Caffeine	29-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
10076532-0	1998	Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats.	Caffeine	95-103	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	22-27
10076532-8	1998	These results indicate that the rat CYP3A subfamily is capable of catalyzing C-8 hydroxylation of caffeine as is the case for human CYP3A4.	Caffeine	98-106	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	36-41
10076532-8	1998	These results indicate that the rat CYP3A subfamily is capable of catalyzing C-8 hydroxylation of caffeine as is the case for human CYP3A4.	Caffeine	98-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	132-138
10076532-10	1998	We concluded that marked sex-dependent strain differences in C-8 hydroxylation of caffeine between Wistar and DA rats are due to the differences in the levels of expression of CYP3A in these strains of rats.	Caffeine	82-90	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	176-181
9625339-0	1998	Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants.	Caffeine	46-54	erythropoietin	Homo sapiens	64-78
9630843-0	1998	Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns.	Caffeine	127-135	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	15-26
9630843-0	1998	Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns.	Caffeine	127-135	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	61-68
9625339-2	1998	Our aim was to determine whether caffeine and theophylline had similar effects on EP production in the premature newborn.	Caffeine	33-41	erythropoietin	Homo sapiens	82-84
9625339-11	1998	This was associated with a rise compared to baseline (median 10.0-0.2 mU/ml) in the mean EP levels in the caffeine group and a decrease from a median of 10.1 to 8.3 mU/ml in the theophylline group, but the EP levels in the two groups at week 7 did not differ significantly.	Caffeine	106-114	erythropoietin	Homo sapiens	89-91
9565293-3	1998	NAT2 activity was calculated from HPLC analysis of the ratio of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 1-methylxanthine (1MX) in the urine.	Caffeine	68-76	N-acetyltransferase 2	Homo sapiens	0-4
9625592-1	1998	In this study, the effects of caffeine on lipoprotein lipase (LPL) gene expression were investigated in the 3T3-F442A preadipocyte cell line during the adipocyte differentiation process by determining LPL enzymatic activity and its messenger RNA (mRNA) level.	Caffeine	30-38	lipoprotein lipase	Mus musculus	62-65
9625592-2	1998	The results demonstrate that caffeine acts on the gene expression of LPL, an early marker of adipocyte differentiation.	Caffeine	29-37	lipoprotein lipase	Mus musculus	69-72
9625592-5	1998	The inhibitory effect of caffeine on LPL mRNA level can be reproduced by theophylline, a phosphodiesterase inhibitor, and by dibutyryl cyclic AMP, a non-metabolizable analog of cyclic AMP.	Caffeine	25-33	lipoprotein lipase	Mus musculus	37-40
9523583-10	1998	Ca2+ release induced by bradykinin and angiotensin II was also inhibited by ryanodine and caffeine, but unaffected by cinnarizine.	Caffeine	90-98	kininogen 1	Bos taurus	24-34
9523583-12	1998	These results suggest that PACAP induces Ca2+ release from ryanodine/caffeine stores through a novel intracellular mechanism independent of both IP3 and cyclic AMP and that the mechanism may be the common pathway through which peptides release Ca2+ in adrenal chromaffin cells.	Caffeine	69-77	adenylate cyclase activating polypeptide 1	Bos taurus	27-32
9523583-0	1998	Pituitary adenylate cyclase-activating polypeptide causes Ca2+ release from ryanodine/caffeine stores through a novel pathway independent of both inositol trisphosphates and cyclic AMP in bovine adrenal medullary cells.	Caffeine	86-94	adenylate cyclase activating polypeptide 1	Bos taurus	0-50
9613583-5	1998	Haploid slg1 deletion strains are sensitive to caffeine, as expected for mutants in the Pkc pathway, as well as a variety of other drugs.	Caffeine	47-55	Slg1p	Saccharomyces cerevisiae S288C	8-12
9613583-8	1998	Sensitivity of the haploid deletion mutants to caffeine can be partially suppressed by overexpression of genes for other components of the Pkc pathway, such as PKC1, SLT2, ROM2, and STE20.	Caffeine	47-55	protein kinase C	Saccharomyces cerevisiae S288C	160-164
9613583-8	1998	Sensitivity of the haploid deletion mutants to caffeine can be partially suppressed by overexpression of genes for other components of the Pkc pathway, such as PKC1, SLT2, ROM2, and STE20.	Caffeine	47-55	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	166-170
9613583-8	1998	Sensitivity of the haploid deletion mutants to caffeine can be partially suppressed by overexpression of genes for other components of the Pkc pathway, such as PKC1, SLT2, ROM2, and STE20.	Caffeine	47-55	Rho family guanine nucleotide exchange factor ROM2	Saccharomyces cerevisiae S288C	172-176
9613583-9	1998	In addition, a SLG1-lacZ reporter construct shows higher expression in the presence of caffeine or magnesium chloride in a wild-type diploid background.	Caffeine	87-95	Slg1p	Saccharomyces cerevisiae S288C	15-19
9525538-1	1998	In a case-control study of 73 women with and 141 women without spontaneous abortion, the authors determined the activity of the three principal caffeine-metabolizing enzymes--cytochrome P-4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase 2--by measuring levels of caffeine metabolites in urine.	Caffeine	144-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	166-194
9497245-5	1998	Correlation analysis of the in vitro contracture-test data available for pedigrees bearing these and other RYR1 mutations showed an exceptionally good correlation between caffeine threshold and tension values, whereas no correlation was observed between halothane threshold and tension values.	Caffeine	171-179	ryanodine receptor 1	Homo sapiens	107-111
9525538-1	1998	In a case-control study of 73 women with and 141 women without spontaneous abortion, the authors determined the activity of the three principal caffeine-metabolizing enzymes--cytochrome P-4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase 2--by measuring levels of caffeine metabolites in urine.	Caffeine	144-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	196-202
9525538-1	1998	In a case-control study of 73 women with and 141 women without spontaneous abortion, the authors determined the activity of the three principal caffeine-metabolizing enzymes--cytochrome P-4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase 2--by measuring levels of caffeine metabolites in urine.	Caffeine	144-152	N-acetyltransferase 2	Homo sapiens	227-248
9491835-0	1998	Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
9638033-11	1998	There was a wide range in the resting BP response to caffeine (combined SBP and DBP ranged from 10-39 mmHg) suggesting that there are marked differences in sensitivity to caffeine, irrespective of individuals" consumption habits.	Caffeine	53-61	selenium binding protein 1	Homo sapiens	72-75
9491835-8	1998	CONCLUSIONS: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	94-100
9681931-0	1998	Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat.	Caffeine	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-92
9483525-7	1998	Caffeine induced a cyclic alteration of [Ca2+]i (oscillation) in 45% of the neonatal superior cervical ganglion neurons when they were maintained without nerve growth factor, but nerve growth factor treatment suppressed the oscillation to 10% of neurons.	Caffeine	0-8	nerve growth factor	Rattus norvegicus	154-173
9483391-5	1998	At 24 h, there was a significant improvement in CRS and reduction in supplementary oxygen requirements in the caffeine group (p &lt; 0.01), in the theophylline group no such significant effects were seen.	Caffeine	110-118	twist family bHLH transcription factor 1	Homo sapiens	48-51
9483391-6	1998	In the study population overall, after 7 days of treatment in both the theophylline and caffeine groups there was an improvement in CRS (p &lt; 0.05 and p &lt; 0.01 respectively) and a reduction in the inspired oxygen concentration (p &lt; 0.05 and p &lt; 0.01 respectively).	Caffeine	88-96	twist family bHLH transcription factor 1	Homo sapiens	132-135
9949549-1	1998	Caffeine in 10(-2) M concentration per se activates ryanodine receptors (RyR) in vitro, thereby increasing the intracellular concentration of Ca2+ ([Ca2+]i).	Caffeine	0-8	ryanodine receptor 2	Rattus norvegicus	52-71
9949549-1	1998	Caffeine in 10(-2) M concentration per se activates ryanodine receptors (RyR) in vitro, thereby increasing the intracellular concentration of Ca2+ ([Ca2+]i).	Caffeine	0-8	ryanodine receptor 2	Rattus norvegicus	73-76
9718083-5	1998	Extracellular Ca2+ (2-10 mM) and high concentration (more than 30 mM) of caffeine activated the RyR3 in CHO cells and increased its intracellular Ca2+ concentration.	Caffeine	73-81	LOW QUALITY PROTEIN: ryanodine receptor 3	Cricetulus griseus	96-100
9718083-6	1998	The enhancement of [3H]-ryanodine binding to the membrane from CHO cells expressing RyR3 was observed by bromoeudistomin D (BED), a caffeine-like powerful Ca2+ releaser, at pCa 5.5.	Caffeine	132-140	LOW QUALITY PROTEIN: ryanodine receptor 3	Cricetulus griseus	84-88
9507508-0	1998	Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women.	Caffeine	38-46	sex hormone binding globulin	Homo sapiens	98-126
9507508-3	1998	The relationships between caffeine-containing beverages (coffee, green tea, black tea, oolong tea, and cola) and serum concentrations of estradiol and sex hormone-binding globulin were evaluated in 50 premenopausal Japanese women.	Caffeine	26-34	sex hormone binding globulin	Homo sapiens	151-179
9430622-0	1998	Caffeine-induced Ca2+ transients and exocytosis in Paramecium cells.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	17-20
9430622-2	1998	Caffeine causes a [Ca2+]i increase in the cortex of Paramecium cells, followed by spillover with considerable attenuation, into central cell regions.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	19-22
9430622-6	1998	Therefore, caffeine may primarily mobilize cortical Ca2+ pools, superimposed by Ca2+ influx and spillover (particularly in tl cells with empty trichocyst docking sites).	Caffeine	11-19	carbonic anhydrase 2	Homo sapiens	52-55
9430622-7	1998	In nd cells, caffeine caused trichocyst contents to decondense internally (Ca2+-dependent stretching, normally occurring only after membrane fusion).	Caffeine	13-21	carbonic anhydrase 2	Homo sapiens	75-78
9430622-9	1998	In this case, quenched-flow and ultrathin section or freeze-fracture analysis revealed dispersal of membrane components (without fusion) subsequent to internal contents decondensation, opposite to normal membrane fusion when a full [Ca2+]i signal was generated by caffeine stimulation (with Ca2+i and Ca2+o available).	Caffeine	264-272	carbonic anhydrase 2	Homo sapiens	233-236
9430622-11	1998	(i) Caffeine can mobilize Ca2+ from cortical stores independent of the presence of Ca2+o.	Caffeine	4-12	carbonic anhydrase 2	Homo sapiens	26-29
9430622-12	1998	(ii) To yield adequate signals for normal exocytosis, Ca2+ release and Ca2+ influx both have to occur during caffeine stimulation.	Caffeine	109-117	carbonic anhydrase 2	Homo sapiens	54-57
9430622-12	1998	(ii) To yield adequate signals for normal exocytosis, Ca2+ release and Ca2+ influx both have to occur during caffeine stimulation.	Caffeine	109-117	carbonic anhydrase 2	Homo sapiens	71-74
9430622-13	1998	(iii) Insufficient [Ca2+]i increase entails caffeine-mediated access of Ca2+ to the secretory contents, thus causing their decondensation before membrane fusion can occur.	Caffeine	44-52	carbonic anhydrase 2	Homo sapiens	20-23
9430622-13	1998	(iii) Insufficient [Ca2+]i increase entails caffeine-mediated access of Ca2+ to the secretory contents, thus causing their decondensation before membrane fusion can occur.	Caffeine	44-52	carbonic anhydrase 2	Homo sapiens	72-75
9681931-5	1998	Similar region-specific effects of caffeine were observed on c-fos mRNA induced by the selective dopamine D2 antagonist raclopride (0.5 mg kg(-1)).	Caffeine	35-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-66
9681931-6	1998	Both haloperidol and raclopride counteracted caffeine-induced c-fos mRNA expression in somatosensory cortex.	Caffeine	45-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
9681931-8	1998	The present data show that caffeine modulates c-fos mRNA induced by dopamine D2 receptor antagonism differentially in sensorimotor and limbic-related areas of striatum.	Caffeine	27-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
9507508-6	1998	High intakes of caffeinated coffee, green tea, and total caffeine were commonly correlated with increasing sex hormone-binding globulin on Days 11 and 22 of the cycle after controlling for potential confounders [Spearman correlation coefficients (r) ranged from 0.23 to 0.31].	Caffeine	57-65	sex hormone binding globulin	Homo sapiens	107-135
9681931-1	1998	By using in situ hybridisation we examined the acute effects of caffeine on haloperidol-induced c-fos mRNA in rat striatum.	Caffeine	64-72	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
9428701-5	1997	When expressed in high-copy number from the PPZ1 promoter, the pzh1 ORF rescues the caffeine-induced lytic defect and slightly decreases the high salt tolerance of S. cerevisiae ppz1delta mutants.	Caffeine	84-92	salt homeostasis regulator	Saccharomyces cerevisiae S288C	44-48
10375757-0	1998	Use of caffeine as a probe for rapid determination of cytochrome P-450 CYP1A2 activity in humans.	Caffeine	7-15	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
9393772-0	1997	Correspondence re: J. S. DeFrank et al., p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine.	Caffeine	120-128	tumor protein p53	Homo sapiens	41-44
9384575-6	1997	In skeletal muscles isolated from newborn RyR3(-/- )mice, but not in those from adult mice, the twitch elicited by electrical stimulation and the contracture induced by caffeine were strongly depressed.	Caffeine	169-177	ryanodine receptor 3	Mus musculus	42-46
9441719-1	1997	The 3-demethylation of caffeine can be used as an index of cytochrome P450 CYP1A2 activity in vivo.	Caffeine	23-31	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	75-81
10467435-0	1997	CAFFEINE INJECTION IN THE DARK PHASE PROLONGS THE NOCTURNAL RISE IN SEROTONIN N-ACETYLTRANSFERASE ACTIVITY AND MELATONIN CONTENT IN THE PINEAL GLAND OF MALE RATS.	Caffeine	0-8	aralkylamine N-acetyltransferase	Rattus norvegicus	68-97
10467435-1	1997	Caffeine, an important member of methylxanthines, induced a prolonged nocturnal rise in pineal melatonin content and an increase in its rate-limiting enzyme serotonin N-acetyltransferase (NAT) activity.	Caffeine	0-8	aralkylamine N-acetyltransferase	Rattus norvegicus	157-186
10467435-1	1997	Caffeine, an important member of methylxanthines, induced a prolonged nocturnal rise in pineal melatonin content and an increase in its rate-limiting enzyme serotonin N-acetyltransferase (NAT) activity.	Caffeine	0-8	N-acetyltransferase 1	Rattus norvegicus	188-191
10467435-2	1997	The highest levels were reached five hours after subcutaneous caffeine injection to male rats in the dark phase, where the NAT activity increased from 920+/-70 pM/pineal/h in the control group to 1190+/-120 pM/pineal/h (P&lt;0.001) in the treated group.	Caffeine	62-70	N-acetyltransferase 1	Rattus norvegicus	123-126
9375692-2	1997	Both adenosine and an adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine, decreased extracellular 5-HT levels, whereas an adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine (CPT), and caffeine increased these levels.	Caffeine	215-223	adenosine A1 receptor	Rattus norvegicus	22-43
9375692-4	1997	When the adenosine A1 receptor was blocked by CPT, the hippocampal extracellular 5-HT level was increased by adenosine, CGS-21680, and PD-125944, and decreased by caffeine, DMPX, and APNEA.	Caffeine	163-171	adenosine A1 receptor	Rattus norvegicus	9-30
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	55-59
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	92-96
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	92-96
9351445-10	1997	Caffeine was found to block both the Kv4.3 and Kv4.2 channels to a similar extent.	Caffeine	0-8	potassium voltage-gated channel subfamily D member 3	Homo sapiens	37-42
9395299-2	1997	The mutant yeast protein leads to sensitivity to caffeine and low concentrations of SDS when expressed in a pkc1 deletion strain.	Caffeine	49-57	protein kinase C	Saccharomyces cerevisiae S288C	108-112
9351445-10	1997	Caffeine was found to block both the Kv4.3 and Kv4.2 channels to a similar extent.	Caffeine	0-8	potassium voltage-gated channel subfamily D member 2	Homo sapiens	47-52
9390106-3	1997	We evaluated CYP1A2 activity by the ratio of the molar urinary concentrations of the three end products of paraxanthine demethylation of caffeine to the molar concentration of a paraxanthine 8-hydroxylation product.	Caffeine	137-145	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
9401965-4	1997	Voltage clamp depolarizations and caffeine applications during superfusion in Ca(2+)-free, Sr(2+)-containing solutions were employed to exchange intracellular Ca2+ with Sr2+.	Caffeine	34-42	Stress response QTL 2	Rattus norvegicus	169-172
9351907-6	1997	Other substrates of CYP1A2, such as phenacetin, imipramine, caffeine, and estradiol, are also inhibitors of flutamide metabolism by CYP1A2.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
9351907-6	1997	Other substrates of CYP1A2, such as phenacetin, imipramine, caffeine, and estradiol, are also inhibitors of flutamide metabolism by CYP1A2.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138
9390105-6	1997	In vivo inhibition of caffeine demethylation and dextromethorphan N-demethylation were consistent with inhibition of CYP1A2 and CYP3A4, respectively.	Caffeine	22-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	117-123
9390105-6	1997	In vivo inhibition of caffeine demethylation and dextromethorphan N-demethylation were consistent with inhibition of CYP1A2 and CYP3A4, respectively.	Caffeine	22-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	128-134
9401965-13	1997	The amplitude of the Ca2+ influx-induced fluorescence transient was 17 +/- 1% of the caffeine-induced transient (n = 5 cells), an indication that fractional utilization of Sr2+ sequestered in the sarcoplasmic reticulum during CISR was low.	Caffeine	85-93	Stress response QTL 2	Rattus norvegicus	172-175
9401965-15	1997	With increased Sr2+ loading, the amplitude of Ca2+ influx- and caffeine-induced fluorescence transients increased, but fractional utilization of sarcoplasmic reticulum divalent cation stores was independent of the degree of Sr2+ loading.	Caffeine	63-71	Stress response QTL 2	Rattus norvegicus	15-18
9300397-2	1997	Here we show that (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid, an agonist at group II metabotropic glutamate receptors, completely blocked long-term potentiation induced by a theta-burst type of stimulation protocol (five pulses at 75 Hz per train, 200 ms inter-train interval) in the CA1 region in vivo.	Caffeine	18-24	carbonic anhydrase 1	Homo sapiens	291-294
9433922-5	1997	These oscillations were inhibited by caffeine which suggests that they were mediated by the inositol trisphosphate receptor Ca2+ release system.	Caffeine	37-45	carbonic anhydrase 2	Homo sapiens	124-127
9326287-0	1997	Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells.	Caffeine	0-8	amyloid beta precursor protein	Homo sapiens	54-84
9334205-8	1997	Linear regression analysis showed that there is a strong correlation (r = 0.95, p < 0.001) between caffeine sensitivity of different RYR1 mutants measured by the cellular Ca2+ photometry assay and by the clinical in vitro caffeine halothane contracture test (IVCT).	Caffeine	99-107	ryanodine receptor 1	Homo sapiens	133-137
9312152-10	1997	Furthermore, caffeine-activated RyRs were also inhibited by sorcin at low [Ca2+] (pCa 7), suggesting that Ca2+ is not an obligatory factor for sorcin inhibition of RyR.	Caffeine	13-21	sorcin	Homo sapiens	60-66
9312152-10	1997	Furthermore, caffeine-activated RyRs were also inhibited by sorcin at low [Ca2+] (pCa 7), suggesting that Ca2+ is not an obligatory factor for sorcin inhibition of RyR.	Caffeine	13-21	ryanodine receptor 2	Homo sapiens	32-35
9321518-1	1997	Caffeine and 7,8-benzoflavone activate CYP3A2 in rat liver microsomes.	Caffeine	0-8	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	39-45
9321518-6	1997	Anti-cytochrome b5, but not anti-cytochrome P450 reductase IgG, diminished the activation effect of caffeine on NAPQI formation.	Caffeine	100-108	cytochrome b5 type A	Rattus norvegicus	5-18
9321518-8	1997	The impairment of NAPQI formation by cytochrome b5 antibody suggests that cytochrome P450 activation by caffeine but not 7,8-benzoflavone is mediated in part through enhancement of the transfer of the second electron to cytochrome P450 from cytochrome b5.	Caffeine	104-112	cytochrome b5 type A	Rattus norvegicus	37-50
9321518-8	1997	The impairment of NAPQI formation by cytochrome b5 antibody suggests that cytochrome P450 activation by caffeine but not 7,8-benzoflavone is mediated in part through enhancement of the transfer of the second electron to cytochrome P450 from cytochrome b5.	Caffeine	104-112	cytochrome b5 type A	Rattus norvegicus	241-254
9399380-5	1997	Caffeine in the beverage rapidly augmented skin conductance responses but, in contrast to the effect of hot water, reduced the skin temperature response and increased SBP (+2.8 mmHg) and DBP (+2.1 mmHg) 30-60 min post-consumption.	Caffeine	0-8	selenium binding protein 1	Homo sapiens	167-170
9399380-5	1997	Caffeine in the beverage rapidly augmented skin conductance responses but, in contrast to the effect of hot water, reduced the skin temperature response and increased SBP (+2.8 mmHg) and DBP (+2.1 mmHg) 30-60 min post-consumption.	Caffeine	0-8	D-box binding PAR bZIP transcription factor	Homo sapiens	187-190
11596199-0	1997	[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].	Caffeine	18-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-87
11596199-1	1997	Caffeine was used as a metabolic probe to measure, in 120 healthy volunteers, the activities of three enzymes, deduced to be N-acetyltransferase(NAT2), CYP1A2 and xanthine oxidase (XO).	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	145-149
11596199-1	1997	Caffeine was used as a metabolic probe to measure, in 120 healthy volunteers, the activities of three enzymes, deduced to be N-acetyltransferase(NAT2), CYP1A2 and xanthine oxidase (XO).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	152-158
9352220-1	1997	Previous studies have shown that caffeine treatment at 20 degrees C causes the intermediate compartment protein p58 to redistribute from the Golgi region without affecting the localization of the Golgi stack protein mannosidase II (J. Jantti, E. Kuismanen, J.	Caffeine	33-41	cyclin dependent kinase 11B	Homo sapiens	112-115
9352220-8	1997	However, if the temperature shift was carried out in the presence of 10 mM caffeine, p58 and beta-COP maintained their peripheral localization, whereas Man II was transported to the Golgi region.	Caffeine	75-83	cyclin dependent kinase 11B	Homo sapiens	85-88
9352311-19	1997	Treatment with ryanodine (100 microM) and caffeine (10 mM) in Ca(2+)-free solution reduced the tension measured 5 min after NA (30 microM) and ET-1 (30 nM) addition, but the sustained response (tension at 25 min) remained unaffected.	Caffeine	42-50	endothelin 1	Bos taurus	143-147
9326287-7	1997	Here, we use caffeine to stimulate ryanodine receptor (RYR)-regulated intracellular calcium release channels and show that internal calcium stores also participate in the genesis of A beta.	Caffeine	13-21	ryanodine receptor 1	Homo sapiens	35-53
9326287-7	1997	Here, we use caffeine to stimulate ryanodine receptor (RYR)-regulated intracellular calcium release channels and show that internal calcium stores also participate in the genesis of A beta.	Caffeine	13-21	ryanodine receptor 1	Homo sapiens	55-58
9326287-7	1997	Here, we use caffeine to stimulate ryanodine receptor (RYR)-regulated intracellular calcium release channels and show that internal calcium stores also participate in the genesis of A beta.	Caffeine	13-21	amyloid beta precursor protein	Homo sapiens	182-188
9326287-8	1997	In cultured HEK293 cells transfected with betaAPP cDNA, caffeine (5-10 mM) significantly increased the release of A beta fourfold compared with control.	Caffeine	56-64	amyloid beta precursor protein	Homo sapiens	114-120
9326287-9	1997	These actions of caffeine were saturable, modulated by ryanodine, and inhibited by the RYR antagonists ruthenium red and procaine.	Caffeine	17-25	ryanodine receptor 1	Homo sapiens	87-90
9326287-10	1997	The calcium reuptake inhibitors thapsigargin and cyclopiazonic acid potentiated caffeine-stimulated A beta release.	Caffeine	80-88	amyloid beta precursor protein	Homo sapiens	100-106
9291123-5	1997	High concentrations of caffeine slowed Ca2+ waves in the cytosol but not in the nucleus.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	39-42
9305876-3	1997	Ca2+ release measurements using the fluorescence Ca2+ indicator fluo 3 revealed that the cloned RyR3 functioned as a caffeine- and ryanodine-sensitive Ca2+ release channel in HEK293 cells.	Caffeine	117-125	ryanodine receptor 3	Homo sapiens	96-100
9305876-10	1997	The cloned RyR3 was activated by ATP, caffeine, and perchlorate, inhibited by Mg2+ and ruthenium red, and modified by ryanodine.	Caffeine	38-46	ryanodine receptor 3	Homo sapiens	11-15
9295356-7	1997	-3H-Ryanodine binding to RyR3 was biphasically dependent on Ca2+, as is true of RyR1, and was stimulated further by adenine nucleotide, caffeine, or high salt concentration.	Caffeine	136-144	ryanodine receptor 3	Oryctolagus cuniculus	25-29
9295356-7	1997	-3H-Ryanodine binding to RyR3 was biphasically dependent on Ca2+, as is true of RyR1, and was stimulated further by adenine nucleotide, caffeine, or high salt concentration.	Caffeine	136-144	ryanodine receptor 1	Oryctolagus cuniculus	80-84
9421173-0	1997	Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.	Caffeine	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
9421173-0	1997	Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.	Caffeine	46-54	neurotensin	Rattus norvegicus	104-115
9421173-0	1997	Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.	Caffeine	46-54	neurotensin	Rattus norvegicus	116-128
9421173-6	1997	The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen.	Caffeine	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
9421173-6	1997	The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen.	Caffeine	54-62	neurotensin	Rattus norvegicus	117-128
9421173-6	1997	The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen.	Caffeine	54-62	neurotensin	Rattus norvegicus	129-141
9421173-8	1997	Thus caffeine induction of striatal preprotachykinin A mRNA and neurotensin/neuromedin N mRNA, but not of preproenkephalin mRNA or prodynorphin mRNA, may at least in part be mediated by a pathway involving Fos protein.	Caffeine	5-13	neurotensin	Rattus norvegicus	64-88
9421173-8	1997	Thus caffeine induction of striatal preprotachykinin A mRNA and neurotensin/neuromedin N mRNA, but not of preproenkephalin mRNA or prodynorphin mRNA, may at least in part be mediated by a pathway involving Fos protein.	Caffeine	5-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	206-209
9281609-2	1997	We investigated the effect of various tea polyphenols and caffeine on the induction of NO synthase (NOS) in thioglycollate-elicited and lipopolysaccharide (LPS)-activated peritoneal macrophages.	Caffeine	58-66	nitric oxide synthase 2	Homo sapiens	87-98
9262169-5	1997	Caffeine treatment (1 g/l, but not 0.1 or 0.3 g/l) tended to increase [3H]CHA binding to the CA3 subfield of the hippocampus, but in no other region studied.	Caffeine	0-8	carbonic anhydrase 3	Mus musculus	93-96
9364486-2	1997	A significant induction of c-fos mRNA, but not of any of the other IEGs, was found 2, 4 and 8 hr after a single injection of 50 mg/kg caffeine.	Caffeine	134-142	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
9364486-4	1997	The ability of caffeine to increase pallidal c-fos mRNA expression was mimicked by the dopamine D2/3 receptor agonist quinpirole (1 or 3 mg/kg), whereas the dopamine D2/3 receptor antagonist raclopride (2 mg/kg) was ineffective.	Caffeine	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-50
9364486-6	1997	The caffeine-induced c-fos mRNA expression was not counteracted by concomitant treatment with raclopride.	Caffeine	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
9364486-9	1997	The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion.	Caffeine	87-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
9364486-9	1997	The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion.	Caffeine	199-207	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
9277347-4	1997	M3 antagonism blocked activation of ICl(Ca) and Icat and a rise in [Ca2+]i, but application of caffeine with methacholine restored Icat and delta Ca(sus).	Caffeine	95-103	catenin beta interacting protein 1	Homo sapiens	131-135
9292231-8	1997	Characterization of RyR functional behaviour with [3H]-ryanodine has indicated extensive similarities between the enriched JFM and parent TC vessicles, as far as the characteristic bell shaped Ca(2+)-dependence of [3H]-ryanodine binding and the dose-dependent sensitization to Ca2+ by caffeine, reflecting the inherent properties of SR Ca(2+)-release channel, as well as concerning the stimulation of [3H]-ryanodine binding by increasing concentrations of KCl.	Caffeine	285-293	LOC100009439	Oryctolagus cuniculus	20-23
9815821-8	1997	This suggests that radiosensitization by CAF and increased cell death is dependent on loss of wt p53 function.	Caffeine	41-44	tumor protein p53	Homo sapiens	97-100
9815821-10	1997	These results demonstrate that G2 checkpoint inhibition with CAF leads to preferential IR cell killing in cell lines in which wt p53 is inactivated and that this increased cell killing is not necessarily dependent on increased IR-induced apoptosis.	Caffeine	61-64	tumor protein p53	Homo sapiens	129-132
9219939-5	1997	A reduction of NGFI-A messenger RNA was found in several subregions of both caudate putamen and nucleus accumbens in caffeine-treated animals.	Caffeine	117-125	early growth response 1	Rattus norvegicus	15-21
9219939-8	1997	In addition, it was found that caffeine, but not SCH 58261 or DPCPX, elevated the expression of NGFI-A and NGFI-B messenger RNA in the cerebral cortex, especially in its parietal part.	Caffeine	31-39	early growth response 1	Rattus norvegicus	96-102
9219939-8	1997	In addition, it was found that caffeine, but not SCH 58261 or DPCPX, elevated the expression of NGFI-A and NGFI-B messenger RNA in the cerebral cortex, especially in its parietal part.	Caffeine	31-39	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	107-113
9295056-8	1997	In vivo caffeine 3-demethylation, which is associated with CYP1A2 activity, co-segregated with acetaminophen susceptibility and showed a significant positive correlation (r = 0.626, p &lt; 0.005) with CYP1A2 mRNA expression in animals from both the susceptible and nonsusceptible groups.	Caffeine	8-16	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	59-65
9295056-8	1997	In vivo caffeine 3-demethylation, which is associated with CYP1A2 activity, co-segregated with acetaminophen susceptibility and showed a significant positive correlation (r = 0.626, p &lt; 0.005) with CYP1A2 mRNA expression in animals from both the susceptible and nonsusceptible groups.	Caffeine	8-16	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	201-207
9230123-5	1997	We show here that palmitoyl-CoA (PCoA) in a complex with a molar excess of bovine ACBP causes a discrete Ca2+ efflux or allows Ca2+ release from the Ca2+-preloaded terminal cisternae fraction by sub-optimal caffeine concentrations.	Caffeine	207-215	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	82-86
9230123-7	1997	Sensitization towards caffeine was a function of both the concentration of the complex and the [PCoA]-to-[ACBP] ratio.	Caffeine	22-30	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	106-110
9230123-12	1997	A non-hydrolysable analogue of PCoA bound to (bovine) ACBP also sensitized the Ca2+ release channel towards caffeine.	Caffeine	108-116	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	54-58
9341678-13	1997	Pak1 may function by modifying and partially stabilizing thermolabile DNA polymerases, perhaps during DNA repair, because pak1 mutant cells are caffeine sensitive.	Caffeine	144-152	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	0-4
9341678-13	1997	Pak1 may function by modifying and partially stabilizing thermolabile DNA polymerases, perhaps during DNA repair, because pak1 mutant cells are caffeine sensitive.	Caffeine	144-152	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	122-126
9277471-6	1997	By applying caffeine, we observed a significant reduction in sarcoplasmic reticulum Ca2+ content after transient Ca2+ overload.	Caffeine	12-20	carbonic anhydrase 2	Rattus norvegicus	84-87
9277471-6	1997	By applying caffeine, we observed a significant reduction in sarcoplasmic reticulum Ca2+ content after transient Ca2+ overload.	Caffeine	12-20	carbonic anhydrase 2	Rattus norvegicus	113-116
9337943-6	1997	Inhibitors of CYPIA2 (caffeine, erythromycin) have the opposite effect.	Caffeine	22-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
9815821-6	1997	This p53-defective cell line was also radiosensitized by CAF, whereas the vector control (AA/PCMV/D), which retained wt p53 activity, was not.	Caffeine	57-60	tumor protein p53	Homo sapiens	5-8
9280160-0	1997	Concurrent elevation of the levels of expression of striatal preproenkephalin and preprodynorphin mRNA in the rat brain by chronic treatment with caffeine.	Caffeine	146-154	prodynorphin	Rattus norvegicus	82-97
9280160-7	1997	In contrast to PPE mRNA, PPD mRNA was increased +117% above control in the nucleus accumbens (NAc) at 20 mg/kg of caffeine.	Caffeine	114-122	prodynorphin	Rattus norvegicus	25-28
18762885-2	1997	2.5-50 microg/mL endotoxin and 1-10 mmol/L caffeine caused concentration-dependent increase of CGRP release from rat spinal cord in vitro.	Caffeine	43-51	calcitonin-related polypeptide alpha	Rattus norvegicus	95-99
9315357-7	1997	Spark frequency was increased approximately 350% by ryanodine and caffeine, suggesting that they represent unitary Ca2+ release through ryanodine receptor (RyR) channels.	Caffeine	66-74	ryanodine receptor 1, skeletal muscle	Mus musculus	136-154
9315357-7	1997	Spark frequency was increased approximately 350% by ryanodine and caffeine, suggesting that they represent unitary Ca2+ release through ryanodine receptor (RyR) channels.	Caffeine	66-74	ryanodine receptor 1, skeletal muscle	Mus musculus	156-159
9218210-17	1997	However, the release of Ca2+ from the internal store triggered by caffeine was voltage independent.	Caffeine	66-74	carbonic anhydrase 2	Rattus norvegicus	24-27
9334905-0	1997	Three-dimensional modelling of human cytochrome P450 1A2 and its interaction with caffeine and MeIQ.	Caffeine	82-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-56
9234194-4	1997	Brief pressure applications of caffeine onto the somata of pyramidal cells caused large transient increases in [Ca2+]i (Ca2+ transients) of 50-600 nM above baseline.	Caffeine	31-39	carbonic anhydrase 2	Rattus norvegicus	112-115
9234194-4	1997	Brief pressure applications of caffeine onto the somata of pyramidal cells caused large transient increases in [Ca2+]i (Ca2+ transients) of 50-600 nM above baseline.	Caffeine	31-39	carbonic anhydrase 2	Rattus norvegicus	120-123
9234194-6	1997	The Ca2+ transients evoked by caffeine at -60 mV were not associated with an inward current, persisted after blocking voltage-activated Ca2+ currents and were completely blocked by bath-applied ryanodine.	Caffeine	30-38	carbonic anhydrase 2	Rattus norvegicus	4-7
9234194-6	1997	The Ca2+ transients evoked by caffeine at -60 mV were not associated with an inward current, persisted after blocking voltage-activated Ca2+ currents and were completely blocked by bath-applied ryanodine.	Caffeine	30-38	carbonic anhydrase 2	Rattus norvegicus	136-139
9234194-10	1997	The Ca2+ transients evoked by closely spaced caffeine pulses rapidly decreased in amplitude, indicating progressive depletion of the Ca2+ stores.	Caffeine	45-53	carbonic anhydrase 2	Rattus norvegicus	4-7
9234194-10	1997	The Ca2+ transients evoked by closely spaced caffeine pulses rapidly decreased in amplitude, indicating progressive depletion of the Ca2+ stores.	Caffeine	45-53	carbonic anhydrase 2	Rattus norvegicus	133-136
9234194-13	1997	Even without prior store depletion the caffeine-induced Ca2+ transients disappeared after 6 min exposure to CPA, suggesting that ryanodine-sensitive Ca2+ stores are maintained at rest by continuous Ca2+ sequestration.	Caffeine	39-47	carbonic anhydrase 2	Rattus norvegicus	56-59
9234194-13	1997	Even without prior store depletion the caffeine-induced Ca2+ transients disappeared after 6 min exposure to CPA, suggesting that ryanodine-sensitive Ca2+ stores are maintained at rest by continuous Ca2+ sequestration.	Caffeine	39-47	carbonic anhydrase 2	Rattus norvegicus	149-152
9234194-13	1997	Even without prior store depletion the caffeine-induced Ca2+ transients disappeared after 6 min exposure to CPA, suggesting that ryanodine-sensitive Ca2+ stores are maintained at rest by continuous Ca2+ sequestration.	Caffeine	39-47	carbonic anhydrase 2	Rattus norvegicus	149-152
9234194-15	1997	Caffeine-depleted Ca2+ stores did not refill in Ca(2+)-free saline, suggesting that the refilling of the stores depends upon Ca2+ influx through a "capacitative-like" transmembrane influx pathway operating at resting membrane potential.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	18-21
9234194-15	1997	Caffeine-depleted Ca2+ stores did not refill in Ca(2+)-free saline, suggesting that the refilling of the stores depends upon Ca2+ influx through a "capacitative-like" transmembrane influx pathway operating at resting membrane potential.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	125-128
9234194-18	1997	Elevations of basal [Ca2+]i produced by bath-applied KCl markedly potentiated (up to 6-fold) the caffeine-induced Ca2+ transients.	Caffeine	97-105	carbonic anhydrase 2	Rattus norvegicus	21-24
9234194-18	1997	Elevations of basal [Ca2+]i produced by bath-applied KCl markedly potentiated (up to 6-fold) the caffeine-induced Ca2+ transients.	Caffeine	97-105	carbonic anhydrase 2	Rattus norvegicus	114-117
9234194-23	1997	Pressure applications of caffeine onto pyramidal cell dendrites evoked local Ca2+ transients similar to those separately evoked in the respective somata.	Caffeine	25-33	carbonic anhydrase 2	Rattus norvegicus	77-80
9309878-4	1997	The effect of caffeine on DNase-I activity served as an in vitro-model system.	Caffeine	14-22	deoxyribonuclease 1	Rattus norvegicus	26-33
9309878-7	1997	At concentrations of 0.06-0.3 mM, caffeine inhibited DNase-I activity by excess substrate.	Caffeine	34-42	deoxyribonuclease 1	Rattus norvegicus	53-60
9309878-9	1997	Besides the reduced permeability of the cells to nucleic acid precursors, the results obtained with the PARP- and DNase-I assays give evidence for the formation of a DNA-caffeine adduct as a prominent mechanism of cellular caffeine effects including DNA repair inhibition.	Caffeine	223-231	deoxyribonuclease 1	Rattus norvegicus	114-121
9222898-11	1997	In 2 mM Fura-2-dialyzed transgenic myocytes caffeine-triggered Cai-transients failed to activate INa-Ca even though the kinetics of inactivation of ICa slowed significantly in caffeine-treated myocytes.	Caffeine	176-184	inhibitor of carbonic anhydrase	Mus musculus	148-151
9187128-7	1997	In low-dose treated G2-M-arrested FA-C cells, caffeine-dependent activation of cdc2 released the G2-M block but failed to protect against apoptosis, suggesting that apoptosis was not a direct consequence of persistent cdc2 kinase inactivation.	Caffeine	46-54	cyclin dependent kinase 1	Homo sapiens	79-83
9223678-7	1997	Combined recordings of membrane current and [Ca2+]i by indo-1 microspectrofluorimetry revealed that ANG II- and ATP-induced currents occurred simultaneously with oscillations in [Ca2+]i whereas the caffeine-induced current was accompanied by only one transient increase in [Ca2+]i.	Caffeine	198-206	angiotensinogen	Rattus norvegicus	100-106
9184081-3	1997	Caffeine and staurosporine were equally effective in attenuating both the radiation-induced increase in cyclin B1 expression and the prolongation of G2 in synchronous and asynchronous HeLa cell populations.	Caffeine	0-8	cyclin B1	Homo sapiens	104-113
9184081-6	1997	An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine.	Caffeine	176-184	cyclin B1	Homo sapiens	15-24
9184081-0	1997	Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine.	Caffeine	140-148	cyclin B1	Homo sapiens	29-38
9184081-6	1997	An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine.	Caffeine	176-184	interleukin 6	Homo sapiens	68-71
9184081-8	1997	These results suggest that both staurosporine and caffeine treatments act on different pathways of cell cycle control in normal and transformed cells, in terms of attenuation of G2 block and diminution of elevated levels of cyclin B1 expression, in response to radiation.	Caffeine	50-58	cyclin B1	Homo sapiens	224-233
9283638-0	1997	Bovine serum albumin potentiates caffeine- or ATP-induced tension in human skinned skeletal muscle fibers.	Caffeine	33-41	albumin	Homo sapiens	7-20
9202749-4	1997	In the present study we used the results of caffeine phenotyping experiments to measure the effects of cigarette smoke and compounds present in meat cooked at high temperature on CYP1A2 activity.	Caffeine	44-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	179-185
9130449-0	1997	Differential effects of the Ca2+ sensitizers caffeine and CGP 48506 on the relaxation rate of rat skinned cardiac trabeculae.	Caffeine	45-53	carbonic anhydrase 2	Rattus norvegicus	28-31
9150277-10	1997	These results indicate that caffeine selectively inhibits agonist-mediated [Ca2+]i rise in human gastric epithelial cells, probably through the blockade of receptor-IP3 signaling pathway, which may affect the mucin secretion.	Caffeine	28-36	LOC100508689	Homo sapiens	209-214
9111331-8	1997	Overexpression of MLP1 suppresses the caffeine-sensitive phenotype of the bck1 delta mutation.	Caffeine	38-46	Mlp1p	Saccharomyces cerevisiae S288C	18-22
9111331-8	1997	Overexpression of MLP1 suppresses the caffeine-sensitive phenotype of the bck1 delta mutation.	Caffeine	38-46	mitogen-activated protein kinase kinase kinase BCK1	Saccharomyces cerevisiae S288C	74-78
9111331-9	1997	The additivity of the mlp1 delta defect with the Mpk1 delta defect with regard to the caffeine sensitivity, combined with the results of genetic epistasis experiments, suggested that the activity of Rlm1 is regulated independently by Mpk1 MAP kinase and the Mlp1 MAP kinase-like kinase.	Caffeine	86-94	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	49-53
9111331-9	1997	The additivity of the mlp1 delta defect with the Mpk1 delta defect with regard to the caffeine sensitivity, combined with the results of genetic epistasis experiments, suggested that the activity of Rlm1 is regulated independently by Mpk1 MAP kinase and the Mlp1 MAP kinase-like kinase.	Caffeine	86-94	Rlm1p	Saccharomyces cerevisiae S288C	199-203
9152602-7	1997	CYP1B1 was also able to catalyze the oxidation of theophylline and caffeine, two prototypic substrates for CYP1A2.	Caffeine	67-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
9152602-7	1997	CYP1B1 was also able to catalyze the oxidation of theophylline and caffeine, two prototypic substrates for CYP1A2.	Caffeine	67-75	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
9145907-4	1997	FK 506 selectively eliminates PCB 95-induced Ca2+ release from SR because Ry1R maintains responsiveness to caffeine and Ca2+.	Caffeine	107-115	pyruvate carboxylase	Homo sapiens	30-33
9124533-5	1997	Exposure to both caffeine and ryanodine inhibited ongoing ACh-induced [Ca2+]i oscillations, suggesting a role for caffeine-sensitive ryanodine receptor (RyR) SR Ca2+ channels.	Caffeine	17-25	ryanodine receptor 1, skeletal muscle	Mus musculus	153-156
9891107-3	1997	NAT2 was phenotyped by high-pressure liquid chromatography of caffeine metabolites in urine.	Caffeine	62-70	N-acetyltransferase 2	Homo sapiens	0-4
9150301-11	1997	The Fos results reveal clear differences in the way that BA (aspirin) and L-54 (ibuprofen + caffeine + paracetamol) affected transmission of the noxious signal.	Caffeine	92-100	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
9343951-7	1997	Methylxanthines (caffeine and theophylline) as well as "classical" calcium-mobilizing agents (ionomycin and thapsigargin) inhibited the expression of VCAM-1 in MME.	Caffeine	17-25	vascular cell adhesion molecule 1	Mus musculus	150-156
9088579-2	1997	Caffeine is the most commonly used model drug to assess CYP1A2 function, but due to the complex metabolism of caffeine, there is a need for an alternative drug to use as an index of CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62
9088579-12	1997	CONCLUSIONS: In summary the theophylline 6 h plasma and 0-12 h urine ratios 1MU/13DMX and 3MX/13DMX, both reflecting N-demethylation seem to be predictors of the CYP1A2 mediated metabolism of theophylline, whereas only the plasma ratio correlated with the caffeine plasma 17DMX/13TMX ratio.	Caffeine	256-264	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	162-168
9063686-5	1997	Therefore, caffeine is an antagonist of both adenosine A1 and A2 receptor subtypes, and carbamazepine is an adenosine A1 receptor antagonist as well as an adenosine A2 receptor agonist.	Caffeine	11-19	adenosine A1 receptor	Homo sapiens	45-73
9030597-6	1997	Using high affinity [3H]ryanodine binding as the experimental approach, we show that this mutation enhances the sensitivity of RYR1 to activating concentrations of Ca2+ and to the exogenous and diagnostically used ligands caffeine and 4-chloro-m-cresol.	Caffeine	222-230	ryanodine receptor 1	Homo sapiens	127-131
9030597-6	1997	Using high affinity [3H]ryanodine binding as the experimental approach, we show that this mutation enhances the sensitivity of RYR1 to activating concentrations of Ca2+ and to the exogenous and diagnostically used ligands caffeine and 4-chloro-m-cresol.	Caffeine	222-230	carbonic anhydrase 2	Homo sapiens	164-167
9343951-7	1997	Methylxanthines (caffeine and theophylline) as well as "classical" calcium-mobilizing agents (ionomycin and thapsigargin) inhibited the expression of VCAM-1 in MME.	Caffeine	17-25	membrane metallo endopeptidase	Mus musculus	160-163
8988947-7	1997	Dietary starch was directly related to SBP and DBP; dietary saturated fatty acid and cholesterol and Keys score were directly related to DBP; dietary magnesium, fiber, and caffeine were inversely related to SBP and DBP; and dietary protein, polyunsaturated fatty acids, the ratio of polyunsaturated to saturated fatty acid, and other simple carbohydrates were inversely related to DBP.	Caffeine	172-180	selenium binding protein 1	Homo sapiens	207-210
9059982-8	1997	Hypersensitivity to CRC agonists, such as caffeine, and an associated hyposensitivity to CRC antagonists such as Mg2+ is also demonstrated.	Caffeine	42-50	ryanodine receptor 1	Sus scrofa	20-23
9250437-5	1997	Caffeine, compared to placebo, was associated with increased arousal, sleep disruption, and elevations in adrenocorticotropic hormone (ACTH) and cortisol.	Caffeine	0-8	proopiomelanocortin	Homo sapiens	106-133
9038895-3	1997	SR Ca2+ release was induced by acetylcholine (ACh), which acts principally through inositol 1,4,5-trisphosphate (IP3) receptors, and by caffeine, which acts principally through ryanodine receptors (RyR).	Caffeine	136-144	ryanodine receptor 1, skeletal muscle	Mus musculus	177-196
9038895-3	1997	SR Ca2+ release was induced by acetylcholine (ACh), which acts principally through inositol 1,4,5-trisphosphate (IP3) receptors, and by caffeine, which acts principally through ryanodine receptors (RyR).	Caffeine	136-144	ryanodine receptor 1, skeletal muscle	Mus musculus	198-201
9231238-4	1997	Thus, an experiment was designed to determine the effect of acute caffeine administration on the circulating concentrations of gonadotrophins and prolactin in the ovariectomized oestradiol-implanted ewe.	Caffeine	66-74	prolactin	Homo sapiens	146-155
9231238-6	1997	Circulating prolactin levels, on the other hand, were significantly (P &lt; 0.01) elevated following intravenous treatment with caffeine.	Caffeine	128-136	prolactin	Homo sapiens	12-21
9231238-9	1997	Furthermore, they show that acute administration of caffeine stimulates prolactin secretion via an action that is independent of oestradiol feedback and which we suggest, may involve the ACTH/adrenal axis.	Caffeine	52-60	prolactin	Homo sapiens	72-81
9231238-9	1997	Furthermore, they show that acute administration of caffeine stimulates prolactin secretion via an action that is independent of oestradiol feedback and which we suggest, may involve the ACTH/adrenal axis.	Caffeine	52-60	proopiomelanocortin	Homo sapiens	187-191
9250437-5	1997	Caffeine, compared to placebo, was associated with increased arousal, sleep disruption, and elevations in adrenocorticotropic hormone (ACTH) and cortisol.	Caffeine	0-8	proopiomelanocortin	Homo sapiens	135-139
9633823-8	1997	Caffeine-induced Ca2+-release was unaffected by the thiol protease inhibitors or activators.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	17-20
8995600-0	1997	HSP72 expression in malignant hyperthermia and normal muscle following exposure to caffeine and halothane.	Caffeine	83-91	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
9633823-11	1997	Yet, when caffeine released comparable amounts of Ca2+, the initial Ca2+ level was fully restored.	Caffeine	10-18	carbonic anhydrase 2	Homo sapiens	50-53
9633823-11	1997	Yet, when caffeine released comparable amounts of Ca2+, the initial Ca2+ level was fully restored.	Caffeine	10-18	carbonic anhydrase 2	Homo sapiens	68-71
9123684-1	1997	A total of 196 patients with urothelial tumours were phenotyped for N-acetyltransferase 2 by the molar ratio of two caffeine metabolites excreted in urine.	Caffeine	116-124	N-acetyltransferase 2	Homo sapiens	68-89
8968086-0	1996	p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine.	Caffeine	79-87	tumor protein p53	Homo sapiens	0-3
8954965-3	1996	Whereas, 5 mM caffeine pretreatment of the 293 cells exhibits a complete inhibition of hypoxia inducted VPF/VEGF expression.	Caffeine	14-22	vascular endothelial growth factor A	Homo sapiens	104-107
8954965-3	1996	Whereas, 5 mM caffeine pretreatment of the 293 cells exhibits a complete inhibition of hypoxia inducted VPF/VEGF expression.	Caffeine	14-22	vascular endothelial growth factor A	Homo sapiens	108-112
9003313-2	1996	Mutant keule embryos have large multinucleate cells with gapped or incomplete cross walls, as well as cell wall stubs that are very similar to those observed upon caffeine inhibition of cytokinesis in plants.	Caffeine	163-171	Sec1/munc18-like (SM) proteins superfamily	Arabidopsis thaliana	7-12
8951351-0	1996	Induction of liver and kidney CYP1A1/1A2 by caffeine in rat.	Caffeine	44-52	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-36
8951351-6	1996	Caffeine caused a dose-dependent elevation of hepatic CYP1A1/1A2 activities in microsomal preparations, which ranged from 1.7- to 6-fold for ethoxyresorufin O-deethylase and 3- to 8.9-fold for methoxy-resorufin O-demethylase according to the dose regimen of 50 and 150 mg caffeine/kg/day for 3 days, respectively.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-60
8951351-6	1996	Caffeine caused a dose-dependent elevation of hepatic CYP1A1/1A2 activities in microsomal preparations, which ranged from 1.7- to 6-fold for ethoxyresorufin O-deethylase and 3- to 8.9-fold for methoxy-resorufin O-demethylase according to the dose regimen of 50 and 150 mg caffeine/kg/day for 3 days, respectively.	Caffeine	272-280	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-60
8951351-7	1996	Northern blot analysis demonstrated that caffeine treatment increased liver CYP1A1 and CYP1A2 mRNA levels over the dose regimen of 50-150 mg caffeine/kg/day for 3 days, respectively.	Caffeine	41-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	76-82
8951351-7	1996	Northern blot analysis demonstrated that caffeine treatment increased liver CYP1A1 and CYP1A2 mRNA levels over the dose regimen of 50-150 mg caffeine/kg/day for 3 days, respectively.	Caffeine	41-49	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	87-93
8951351-8	1996	The result of this study demonstrates that caffeine increases its own metabolism in a dose-dependent manner and induces CYP1A1/1A2 expression through either transcriptional activation or mRNA stabilization.	Caffeine	43-51	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-126
8968086-4	1996	However, the introduction of 2 mM caffeine led to a sensitization enhancement ratio (at 10% survival) of 1.8 in p53(-/-) cells, but only 1.3 in wild-type (p53+/+) cells.	Caffeine	34-42	tumor protein p53	Homo sapiens	112-115
8968086-4	1996	However, the introduction of 2 mM caffeine led to a sensitization enhancement ratio (at 10% survival) of 1.8 in p53(-/-) cells, but only 1.3 in wild-type (p53+/+) cells.	Caffeine	34-42	tumor protein p53	Homo sapiens	155-158
8968086-6	1996	The differential sensitivity of p53(-/-) cells to X-rays and caffeine was thought to be due to override of the G2-M block to cell cycle progression.	Caffeine	61-69	tumor protein p53	Homo sapiens	32-35
8968086-9	1996	However, for p53(-/-) cells, a greater proportion were in S phase after treatment with caffeine, and a complete loss of S-phase delay was observed after UV irradiation.	Caffeine	87-95	tumor protein p53	Homo sapiens	13-16
8968086-1	1996	We have shown previously that p53(-/-) fibroblasts show greater sensitization by caffeine to the lethal effects of ionizing radiation compared with p53(+/+) cells.	Caffeine	81-89	tumor protein p53	Homo sapiens	30-33
8968086-11	1996	Greater sensitization of p53(-/-) cells to caffeine could be mediated via override of S-phase delay.	Caffeine	43-51	tumor protein p53	Homo sapiens	25-28
9014823-5	1996	The actin of IL-7 blocked by the addition of the protein kinase A stimulator caffeine and the synthetic glucocorticoid dexamethasone.	Caffeine	77-85	interleukin 7	Homo sapiens	13-17
8996794-12	1996	After bicuculline or PTZ treatment, c-fos mRNA expression was weaker in the cerebral cortex in animals receiving caffeine, irrespective of whether the animals had seizures or not.	Caffeine	113-121	FBJ osteosarcoma oncogene	Mus musculus	36-41
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Caffeine	268-276	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	33-40
8951977-0	1996	Stress-like adrenocorticotropin responses to caffeine in young healthy men.	Caffeine	45-53	proopiomelanocortin	Homo sapiens	12-31
8951977-1	1996	The effects of oral caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) on plasma adrenocorticotropin (ACTH) and cortisol (CORT) were tested in 47 healthy young men at rest in a double-blind, placebo-controlled, crossover study.	Caffeine	20-28	proopiomelanocortin	Homo sapiens	85-104
8951977-1	1996	The effects of oral caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) on plasma adrenocorticotropin (ACTH) and cortisol (CORT) were tested in 47 healthy young men at rest in a double-blind, placebo-controlled, crossover study.	Caffeine	20-28	proopiomelanocortin	Homo sapiens	106-110
8951977-1	1996	The effects of oral caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) on plasma adrenocorticotropin (ACTH) and cortisol (CORT) were tested in 47 healthy young men at rest in a double-blind, placebo-controlled, crossover study.	Caffeine	20-28	cortistatin	Homo sapiens	126-130
8951977-2	1996	Following caffeine, ACTH was significantly elevated at all times from 30 min to 180 min, and CORT was elevated from 60 min to 120 min (Fs &gt; or = 8.4, ps &lt; 0.01).	Caffeine	10-18	proopiomelanocortin	Homo sapiens	20-24
8951977-5	1996	Caffeine"s known ability to increase CORT production appears at least partly due to an increase in ACTH release at the pituitary.	Caffeine	0-8	cortistatin	Homo sapiens	37-41
8951977-5	1996	Caffeine"s known ability to increase CORT production appears at least partly due to an increase in ACTH release at the pituitary.	Caffeine	0-8	proopiomelanocortin	Homo sapiens	99-103
8823059-7	1996	Sex hormone-binding globulin levels were positively associated with increasing caffeine intake (adjusted r = 0.09, p = 0.03).	Caffeine	79-87	sex hormone binding globulin	Homo sapiens	0-28
8905310-0	1996	Relationship of plasma renin activity with caffeine intake and physical training in mild hypertensive men.	Caffeine	43-51	renin	Homo sapiens	23-28
8981459-4	1996	No other agonists produced SNB, except (1S, 3S)-ACPD, which may be attributable to a nonselective action at mGluR1.	Caffeine	39-47	homer scaffold protein 2	Homo sapiens	48-52
8824289-2	1996	PPZ1 is also important for cell integrity, as ppz1Delta cells undergo lysis under caffeine stress and PPZ1 overexpression overrides the lytic defect of mutants in the protein kinase C/mitogen-activated protein (MAP) kinase pathway.	Caffeine	82-90	salt homeostasis regulator	Saccharomyces cerevisiae S288C	0-4
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Caffeine	268-276	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Caffeine	268-276	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	90-97
8837615-0	1996	Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase.	Caffeine	55-63	tumor protein p53	Homo sapiens	32-35
8896600-6	1996	Administration of caffeine, an agent that removes inhibitory phosphorylations on inactive Cdc2/cyclin B complexes, specifically induced mitotic catastrophe in pRb-deficient myocytes, consistent with the observation that the majority of pRb-deficient myocytes arrest in S and G2.	Caffeine	18-26	cyclin-dependent kinase 1	Mus musculus	90-94
8896600-6	1996	Administration of caffeine, an agent that removes inhibitory phosphorylations on inactive Cdc2/cyclin B complexes, specifically induced mitotic catastrophe in pRb-deficient myocytes, consistent with the observation that the majority of pRb-deficient myocytes arrest in S and G2.	Caffeine	18-26	RB transcriptional corepressor 1	Mus musculus	159-162
8908595-3	1996	Modulators of human MeWo melanoma Ca2+ concentration and stores, including ionomycin, thapsigargin, dantrolene and caffeine, inhibited cell adhesion stabilization to fibronectin; however, removal of Ca2+ from the extracellular medium did not affect stabilization.	Caffeine	115-123	fibronectin 1	Homo sapiens	166-177
8837615-0	1996	Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase.	Caffeine	55-63	cyclin dependent kinase 1	Homo sapiens	87-94
8837615-6	1996	We demonstrate that abrogation of G2 arrest by caffeine-mediated activation of p34cdc2 kinase results in the selective sensitization of p53-deficient primary and tumor cells to irradiation-induced apoptosis.	Caffeine	47-55	cyclin dependent kinase 1	Homo sapiens	79-86
8837615-6	1996	We demonstrate that abrogation of G2 arrest by caffeine-mediated activation of p34cdc2 kinase results in the selective sensitization of p53-deficient primary and tumor cells to irradiation-induced apoptosis.	Caffeine	47-55	tumor protein p53	Homo sapiens	136-139
8923605-3	1996	The patients were phenotyped for N-acetyltransferase 2 (NAT2) by Grant"s caffeine test.	Caffeine	73-81	N-acetyltransferase 2	Homo sapiens	33-54
8887777-7	1996	These channels were unequivocally identified as BKca channels due to their sensitivity to caffeine (10 mM) and iberiotoxin (20 nM), and their non-stationary kinetic properties.	Caffeine	90-98	calcium-activated potassium channel subunit alpha-1	Oryctolagus cuniculus	48-52
8923605-3	1996	The patients were phenotyped for N-acetyltransferase 2 (NAT2) by Grant"s caffeine test.	Caffeine	73-81	N-acetyltransferase 2	Homo sapiens	56-60
8923605-5	1996	RESULTS: The antimode in the NAT2 phenotyping with the caffeine test (AFMU: IX ratio) was 1.0, as evidenced by additional genotyping of the subgroup of 54 patients.	Caffeine	55-63	N-acetyltransferase 2	Homo sapiens	29-33
8877069-0	1996	Correspondence re: letter to the editor by B. K. Tang and W. Kalow on CYP1A2 phenotyping using caffeine.	Caffeine	95-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
8853354-2	1996	The time course of I(tail) followed that of Cai transients I(tail) was suppressed by dialyzing cells with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, applying 5 mM caffeine, or substituting external Na+ with Li+, indicating that this current was mainly generated by INa/Ca.	Caffeine	191-199	internexin neuronal intermediate filament protein alpha	Homo sapiens	293-296
8704210-10	1996	Caffeine, a known G2 checkpoint inhibitor, not only inhibited G2 accumulation seen in both cell lines but also caused the resistant HSC536N (+FAC) to become as sensitive to MMC as HSC536N (mock) cell line.	Caffeine	0-8	FA complementation group C	Homo sapiens	142-145
8800197-8	1996	After UV B-irradiation the inactivation of Cdk1 was less pronounced and only partially diminished in the presence of caffeine.	Caffeine	117-125	cyclin dependent kinase 1	Homo sapiens	43-47
17451311-2	1996	Metabolism of caffeine, catalysed by cytochrome P-4S0 1A2(CYP1A2), was inhibited most, while hexobarbitone and antipyrine metabolism were inhibited to a lesser, though significant, degree.	Caffeine	14-22	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	58-64
8856488-15	1996	caffeine (10 micrograms/kg/min) on hydralazine-induced (1 and 10 mg/kg, administered intraperitoneally) changes in renal secretion of renin and renal NE spillover were investigated.	Caffeine	0-8	renin	Rattus norvegicus	134-139
8823236-5	1996	The CYP1A2 activity was determined by means of a urinary caffeine test.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
8964480-4	1996	Treatment of cells with caffeine decreased the p53wt content and increased the proportion of metaphases with chromosome breaks; however, it did not induce hyperdiploidy in the majority of cell lines.	Caffeine	24-32	tumor protein p53	Homo sapiens	47-50
8856488-19	1996	caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively).	Caffeine	0-8	renin	Rattus norvegicus	65-70
8856488-19	1996	caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively).	Caffeine	0-8	renin	Rattus norvegicus	186-191
8856488-19	1996	caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively).	Caffeine	0-8	renin	Rattus norvegicus	186-191
8856488-20	1996	The enhanced renin-secretion response to hydralazine in caffeine-treated rats was accompanied by augmented hydralazine-induced increase in renal NE spillover (p = 0.035).	Caffeine	56-64	renin	Rattus norvegicus	13-18
8856488-21	1996	These data strongly support the hypothesis of a CNS adenosine brake on renin release that is disabled by caffeine.	Caffeine	105-113	renin	Rattus norvegicus	71-76
8768693-2	1996	ANG II stimulated Ca++ channel current through L-type Ca++ channels and initiated a slow and small increase in the cytoplasmic Ca++ concentration in cells in which intracellular Ca++ stores had been depleted by pretreatment with ryanodine and caffeine.	Caffeine	243-251	angiotensinogen	Rattus norvegicus	0-6
9201779-3	1996	The oddball paradigm, but not the single-tone paradigm, showed that the P300 amplitude and the area were significantly increased 30 min after ingestion of caffeine and significantly decreased 30 min after ingestion of placebo.	Caffeine	155-163	E1A binding protein p300	Homo sapiens	72-76
8873215-0	1996	Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.	Caffeine	18-26	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	8-14
8873215-1	1996	We investigated the involvement of CYP1A2 in the pharmacokinetics and metabolism of caffeine using mice lacking its expression (CYP1A2 -/-).	Caffeine	84-92	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	35-41
8873215-2	1996	The half-life of caffeine elimination from blood was seven times longer in the CYP1A2 -/- than wild-type mice.	Caffeine	17-25	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	79-85
8873215-6	1996	Caffeine 3-demethylated metabolites thought previously to be characteristic of CYP1A2 (especially 1-methylxanthine and I-methylurate) were also found in the urines of the CYP1A2-/-animals, although at 40% of the level found in wild-type mice.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	79-85
8873215-6	1996	Caffeine 3-demethylated metabolites thought previously to be characteristic of CYP1A2 (especially 1-methylxanthine and I-methylurate) were also found in the urines of the CYP1A2-/-animals, although at 40% of the level found in wild-type mice.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	171-177
8873215-7	1996	These data indicate that the clearance of caffeine in wild-type mice is primarily determined by CYP1A2.	Caffeine	42-50	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	96-102
9201779-7	1996	These findings suggest that the caffeine-induced increase in the P300 amplitude may have resulted from the increased allocation of attentional resources to the discriminating process which was not, however, accompanied by facilitation of the process and that caffeine may specifically stimulate the discriminating process involved in the oddball paradigm.	Caffeine	32-40	E1A binding protein p300	Homo sapiens	65-69
9201779-7	1996	These findings suggest that the caffeine-induced increase in the P300 amplitude may have resulted from the increased allocation of attentional resources to the discriminating process which was not, however, accompanied by facilitation of the process and that caffeine may specifically stimulate the discriminating process involved in the oddball paradigm.	Caffeine	259-267	E1A binding protein p300	Homo sapiens	65-69
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	14-22	insulin	Homo sapiens	112-119
8856488-0	1996	Central effects of caffeine on renal renin secretion and norepinephrine spillover.	Caffeine	19-27	renin	Rattus norvegicus	37-42
8856488-2	1996	The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release.	Caffeine	91-99	renin	Rattus norvegicus	110-115
8856488-2	1996	The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release.	Caffeine	91-99	renin	Rattus norvegicus	197-202
8692199-7	1996	Modification of endogenous and exogenous p53 expression by caffeine, which interferes with normal induction of p53 in response to DNA damage, showed no correlation between the induction of chromosome breaks and heteroploidy.	Caffeine	59-67	tumor protein p53	Homo sapiens	41-44
8692199-7	1996	Modification of endogenous and exogenous p53 expression by caffeine, which interferes with normal induction of p53 in response to DNA damage, showed no correlation between the induction of chromosome breaks and heteroploidy.	Caffeine	59-67	tumor protein p53	Homo sapiens	111-114
8692199-8	1996	We conclude that the caffeine- or mutant p53-induced increase in the frequency of chromosomal breaks in dividing LIM1215 cells is assonated with inactivation of wt-p53 function(s) responsible for control of G1 checkpoint and/or DNA repair, while numerical chromosome changes in these cells may be a result of elimination or modification of a separate p53 function, or due to gain-of-function activities of p53 mutants.	Caffeine	21-29	tumor protein p53	Homo sapiens	41-44
8692199-8	1996	We conclude that the caffeine- or mutant p53-induced increase in the frequency of chromosomal breaks in dividing LIM1215 cells is assonated with inactivation of wt-p53 function(s) responsible for control of G1 checkpoint and/or DNA repair, while numerical chromosome changes in these cells may be a result of elimination or modification of a separate p53 function, or due to gain-of-function activities of p53 mutants.	Caffeine	21-29	tumor protein p53	Homo sapiens	164-167
8692199-8	1996	We conclude that the caffeine- or mutant p53-induced increase in the frequency of chromosomal breaks in dividing LIM1215 cells is assonated with inactivation of wt-p53 function(s) responsible for control of G1 checkpoint and/or DNA repair, while numerical chromosome changes in these cells may be a result of elimination or modification of a separate p53 function, or due to gain-of-function activities of p53 mutants.	Caffeine	21-29	tumor protein p53	Homo sapiens	164-167
8692199-8	1996	We conclude that the caffeine- or mutant p53-induced increase in the frequency of chromosomal breaks in dividing LIM1215 cells is assonated with inactivation of wt-p53 function(s) responsible for control of G1 checkpoint and/or DNA repair, while numerical chromosome changes in these cells may be a result of elimination or modification of a separate p53 function, or due to gain-of-function activities of p53 mutants.	Caffeine	21-29	tumor protein p53	Homo sapiens	164-167
8689813-3	1996	The NAT2 genotype was assessed by polymerase chain reaction and restriction fragment length polymorphism, the NAT2 phenotype was determined by caffeine test (urinary metabolic ratio of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil and 1-methylxanthine).	Caffeine	143-151	N-acetyltransferase 2	Homo sapiens	110-114
8836254-6	1996	The metabotropic glutamate receptor agonist, ACPD, also inhibited the caffeine-stimulated rise in [Ca2+]i.	Caffeine	70-78	homer scaffold protein 2	Homo sapiens	45-49
8764355-8	1996	Our results suggest that CGRP relaxes the porcine coronary artery by the following mechanisms: 1) the inhibition of Ca++ influx stimulated by HIS and by high-K+ depolarization, 2) the reduction of HIS-induced release of intracellular Ca++, without affecting a caffeine-sensitive mechanism, 3) an active decrease in the resting levels of [Ca++]i and 4) a decrease in the Ca(++)-sensitivity of the contractile apparatus.	Caffeine	260-268	calcitonin related polypeptide alpha	Homo sapiens	25-29
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	14-22	insulin	Homo sapiens	214-221
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	14-22	endothelin 1	Homo sapiens	256-260
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	59-67	endothelin 1	Homo sapiens	5-9
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	59-67	insulin	Homo sapiens	112-119
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	59-67	insulin	Homo sapiens	214-221
8666136-8	1996	When ET-1 and caffeine were given in succession, a sizable caffeine-sensitive Ca2+ store could be released from insulin-treated cells but not control cells, indicating that the sarcoplasmic reticulum Ca2+ store of insulin-treated cells was not depleted by ET-1.	Caffeine	59-67	endothelin 1	Homo sapiens	256-260
8764168-7	1996	The Cam2+ responses to caffeine (5 mM) or inositol trisphosphate (IP3) applied intracellularly via a patch-clamp pipette were not affected by genistein.	Caffeine	23-31	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	4-8
8671764-5	1996	Caffeine inhibits cAMP phosphodiesterase, which is needed for dephosphorylating p34(cdc2) kinase and initiating OM.	Caffeine	0-8	alpha- and gamma-adaptin binding protein	Mus musculus	80-83
8671764-5	1996	Caffeine inhibits cAMP phosphodiesterase, which is needed for dephosphorylating p34(cdc2) kinase and initiating OM.	Caffeine	0-8	cyclin-dependent kinase 1	Mus musculus	84-88
8799528-0	1996	CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine.	Caffeine	78-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
8799528-6	1996	Among females and nonsmokers, those subjects who experienced toxic effects had lower caffeine N3-demethylation index (CYP1A2 activity) compared with unaffected females (1.87 +/- 0.51 vs 1.47 +/- 0.27, P &lt; 0.0005) and nonsmokers (1.69 +/- 0.23 vs 1.49 +/- 0.31, P &lt; 0.02).	Caffeine	85-93	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124
8799528-8	1996	We conclude that CYP1A2 activity, gender and smoking are variables to be considered as influencing the toxicity of caffeine.	Caffeine	115-123	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
8649366-3	1996	At permissive temperatures, bro1 mutants are sensitive to caffeine and respond abnormally to nutrient limitation.	Caffeine	58-66	Bro1p	Saccharomyces cerevisiae S288C	28-32
8681487-1	1996	OBJECTIVES: A number of caffeine metabolite ratios (CMRs) have been proposed to measure CYP1A2 activity in vivo.	Caffeine	24-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94
8781785-11	1996	The CLint ratio decreased in a regular fashion as the hepatocyte CLint increased from 1.4 microliters/min (caffeine) to 105 microliters/min (ondansetron).	Caffeine	107-115	clathrin interactor 1	Rattus norvegicus	4-9
8781785-11	1996	The CLint ratio decreased in a regular fashion as the hepatocyte CLint increased from 1.4 microliters/min (caffeine) to 105 microliters/min (ondansetron).	Caffeine	107-115	clathrin interactor 1	Rattus norvegicus	65-70
8670194-8	1996	Caffeine inhibited the actions of CCK-OPE, whereas ryanodine did not have any effects.	Caffeine	0-8	cholecystokinin	Homo sapiens	34-37
8738764-0	1996	Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-89
8738764-1	1996	Caffeine metabolism via the 3-demethylation pathway is sequentially catalyzed by cytochrome P4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-99
8738764-1	1996	Caffeine metabolism via the 3-demethylation pathway is sequentially catalyzed by cytochrome P4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	101-107
8620606-5	1996	The Ca2+ content of the sarcoplasmic reticulum (SR) was measured by applying caffeine (10 mmol/L).	Caffeine	77-85	carbonic anhydrase 2	Rattus norvegicus	4-7
8735685-8	1996	with increased AUC was consistent with a CYP1A2-dependent inhibition of caffeine N-demethylation which was further supported by significant decreases in the (AFMU+1U+1X)/17U and (AFMU+1U+1X)/17X urinary metabolic ratios.	Caffeine	72-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
8620606-9	1996	The rate of removal of Ca2+ from the cytoplasm by non-SR mechanisms was measured by adding caffeine (10 mmol/L) and measuring the rate constant of decay of the resulting increase of [Ca2+]i.	Caffeine	91-99	carbonic anhydrase 2	Rattus norvegicus	23-26
8662190-3	1996	Both slt2delta and lyt2 mutants displayed a caffeine-sensitive phenotype consisting of cell lysis that was not dependent on temperature.	Caffeine	44-52	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	19-23
8662190-4	1996	Caffeine concentrations affecting the growth of these mutant strains were dependent on the genetic background, the SSD1 allele being very significant in this regard.	Caffeine	0-8	mRNA-binding translational repressor SSD1	Saccharomyces cerevisiae S288C	115-119
8662190-9	1996	Keywords Yeast middle dot SLT2 middle dot MAP-kinase middle dot Caffeine	Caffeine	64-72	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	26-30
8723732-0	1996	Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats.	Caffeine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	50-56
8723732-7	1996	The induced MROD activity caused by consumption of green tea, black tea, and caffeine corresponded to the increase in liver microsomal CYP1A2 protein, as determined by immunoblot analysis.	Caffeine	77-85	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	135-141
8723732-10	1996	The present study establishes caffeine as an inducer of CYP1A2 and demonstrates that caffeine, not tea polyphenols, is the component in tea responsible for the induction of this enzyme.	Caffeine	30-38	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	56-62
8723732-10	1996	The present study establishes caffeine as an inducer of CYP1A2 and demonstrates that caffeine, not tea polyphenols, is the component in tea responsible for the induction of this enzyme.	Caffeine	85-93	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	56-62
8727538-2	1996	Caffeine sensitivity was defined as the threshold concentration inducing &gt; 10% of the maximal tension obtained after the fiber was loaded with a 1.6 x 10(-2) mM Ca2+ solution for 30 s. Significant difference in the mean caffeine sensitivity was found between type I masseter fibers [2.57 +/- 1.32 (SD) mM] vs. type I (6.02 +/- 1.74 mM) and type II vastus lateralis fibers (11.25 +/- 3.13 mM).	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	164-167
8733578-4	1996	Most of the AII-evoked increases in [Ca2+]i were reduced by about 60% after pretreatment with ryanodine and caffeine to deplete intracellular Ca2+ stores.	Caffeine	108-116	angiotensinogen	Rattus norvegicus	12-15
8733578-5	1996	However, in some cells the AII-induced Ca2+ responses were of small amplitude and resembled those obtained in the presence of ryanodine and caffeine.	Caffeine	140-148	angiotensinogen	Rattus norvegicus	27-30
9019533-11	1996	Ca(2+)-induced Ca2+ release from caffeine-sensitive stores occurred during depolarization.	Caffeine	33-41	carbonic anhydrase 2	Rattus norvegicus	15-18
9019536-18	1996	This is probably due to sarcoplasmic reticulum (SR) Ca2+ release induced by NKA or caffeine, followed by inhibition of the Ca(2+)-induced Ca2+ release from the SR. 6.	Caffeine	83-91	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	52-55
9019536-19	1996	The present results indicate that I[Cl(Ca)] can be activated by SR Ca2+ release due to NKA or caffeine (through IP(3) or ryanodine receptors) as well as by Ca2+ influx due to I(Ca,L).	Caffeine	94-102	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	67-70
8721670-4	1996	Caffeine (CAF), which releases Ca2+ from Ca(2+)-sensitive stores, induced a two-fold increase in [Ca2+]cyt.	Caffeine	0-8	caffeine susceptibility	Mus musculus	10-13
8635212-11	1996	The TRAP-dependent rise in intracellular calcium also is not inhibited by verapamil or removal of extracellular calcium but is markedly attenuated by depletion of sarcoplasmic reticular calcium stores by caffeine.	Caffeine	204-212	tudor domain containing 7	Rattus norvegicus	4-8
8867052-6	1996	Agents that mobilize intracellular Ca(2+)-stores such as methacholine, caffeine and bradykinin resulted in different cytosolic Ca2+ and exocytosis responses at the rat and bovine chromaffin cells.	Caffeine	71-79	carbonic anhydrase 2	Rattus norvegicus	127-130
8812665-3	1996	By measuring the single-channel properties of the RyR-FKBP complex reconstituted into planar lipid bilayers, we showed that FKBP12 modulates channel gating by decreasing channels with subconductance states, decreasing open probability after caffeine activation, and increasing mean open time.	Caffeine	241-249	FKBP prolyl isomerase 1A L homeolog	Xenopus laevis	124-130
9156692-1	1996	At least six urinary metabolite ratios of caffeine have been proposed as probes for in vivo CYP1A2 activity and three for in vivo NAT2 activity.	Caffeine	42-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	92-98
8778866-9	1996	The caffeine produced a significant increase in metabolic rate during the nap.	Caffeine	4-12	catenin beta like 1	Homo sapiens	74-77
8927499-2	1996	The goal was to distinguish between two schemes proposed to explain the phenomenon of "quantal" Ca2+ release from caffeine-sensitive Ca2+ stores in muscle and other tissues: (1) all-or-none (true quantal) Ca2+ release from functionally discrete stores that have different sensitivities to caffeine; or (2) adaptive behavior of individual release sites, each responding transiently and repeatedly to incremental caffeine doses.	Caffeine	114-122	carbonic anhydrase 2	Mus musculus	96-99
8927499-2	1996	The goal was to distinguish between two schemes proposed to explain the phenomenon of "quantal" Ca2+ release from caffeine-sensitive Ca2+ stores in muscle and other tissues: (1) all-or-none (true quantal) Ca2+ release from functionally discrete stores that have different sensitivities to caffeine; or (2) adaptive behavior of individual release sites, each responding transiently and repeatedly to incremental caffeine doses.	Caffeine	114-122	carbonic anhydrase 2	Mus musculus	133-136
8927499-2	1996	The goal was to distinguish between two schemes proposed to explain the phenomenon of "quantal" Ca2+ release from caffeine-sensitive Ca2+ stores in muscle and other tissues: (1) all-or-none (true quantal) Ca2+ release from functionally discrete stores that have different sensitivities to caffeine; or (2) adaptive behavior of individual release sites, each responding transiently and repeatedly to incremental caffeine doses.	Caffeine	114-122	carbonic anhydrase 2	Mus musculus	133-136
8927499-3	1996	Our results showed that Ca2+ release induced by K+ or caffeine occurs in discrete loci within the cell.	Caffeine	54-62	carbonic anhydrase 2	Mus musculus	24-27
8927499-6	1996	Ca2+ release, at a given site, triggered by a submaximal dose of caffeine was transient and could be reactivated by addition of a higher caffeine dose, showing the same type of adaptive behavior as measured globally from larger areas of the cell.	Caffeine	65-73	carbonic anhydrase 2	Mus musculus	0-3
8927499-6	1996	Ca2+ release, at a given site, triggered by a submaximal dose of caffeine was transient and could be reactivated by addition of a higher caffeine dose, showing the same type of adaptive behavior as measured globally from larger areas of the cell.	Caffeine	137-145	carbonic anhydrase 2	Mus musculus	0-3
9156694-0	1996	Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.	Caffeine	14-22	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
9156694-0	1996	Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.	Caffeine	14-22	N-acetyltransferase 2	Homo sapiens	50-54
9156694-0	1996	Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.	Caffeine	14-22	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	59-65
9156694-1	1996	Caffeine is used to phenotype subjects in vivo for the cytochrome P450 isoforms CYP1A2 and CYP2E1, and for N-acetyltransferase type 2 (NAT2).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
9156694-1	1996	Caffeine is used to phenotype subjects in vivo for the cytochrome P450 isoforms CYP1A2 and CYP2E1, and for N-acetyltransferase type 2 (NAT2).	Caffeine	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	91-97
9156694-1	1996	Caffeine is used to phenotype subjects in vivo for the cytochrome P450 isoforms CYP1A2 and CYP2E1, and for N-acetyltransferase type 2 (NAT2).	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	107-133
9156694-1	1996	Caffeine is used to phenotype subjects in vivo for the cytochrome P450 isoforms CYP1A2 and CYP2E1, and for N-acetyltransferase type 2 (NAT2).	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	135-139
9156694-7	1996	Caffeine clearance and paraxanthine/caffeine ratios correlated most highly to intrinsic clearance of caffeine 3-demethylation and to CYP1A2 immunoreactivity (r= 0.584-0.82), whereas urinary CYP1A2 ratios correlated less strongly with CYP1A2 parameters in vitro.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	133-139
9156694-7	1996	Caffeine clearance and paraxanthine/caffeine ratios correlated most highly to intrinsic clearance of caffeine 3-demethylation and to CYP1A2 immunoreactivity (r= 0.584-0.82), whereas urinary CYP1A2 ratios correlated less strongly with CYP1A2 parameters in vitro.	Caffeine	36-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	133-139
9156694-10	1996	CYP1A2 activity, thus, is the major determinant of caffeine clearance and the paraxanthine/caffeine ratios in vivo, of which the saliva ratio 6 h postdose appears as the most advantageous parameter.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
9156694-10	1996	CYP1A2 activity, thus, is the major determinant of caffeine clearance and the paraxanthine/caffeine ratios in vivo, of which the saliva ratio 6 h postdose appears as the most advantageous parameter.	Caffeine	91-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
9156694-11	1996	The results confirm that phenotyping using caffeine provides valid estimates of CYP1A2 and NAT2 activity.	Caffeine	43-51	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
9156694-11	1996	The results confirm that phenotyping using caffeine provides valid estimates of CYP1A2 and NAT2 activity.	Caffeine	43-51	N-acetyltransferase 2	Homo sapiens	91-95
8695020-5	1996	Parathyroid hormone (PTH) levels decreased after CAF abstinence in 14 of 18 HTN subjects, including all seven subjects consuming less than 700 mg calcium daily.	Caffeine	49-52	parathyroid hormone	Homo sapiens	0-19
8695020-5	1996	Parathyroid hormone (PTH) levels decreased after CAF abstinence in 14 of 18 HTN subjects, including all seven subjects consuming less than 700 mg calcium daily.	Caffeine	49-52	parathyroid hormone	Homo sapiens	21-24
8653991-1	1996	OBJECTIVE: A number of caffeine metabolite ratios have been proposed to measure CYP1A2 activity in vivo.	Caffeine	23-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
8804157-2	1996	In the presence of thapsigargin, a Ca(2+)-ATPase inhibitor of inositol (1, 4, 5) triphosphate (InsP3)-sensitive Ca2+ stores, caffeine caused an increase in [Ca2+]i, which was inhibited by treatment with ryanodine (a ligand to the Ca(2+)-induced Ca2+ release channels).	Caffeine	125-133	carbonic anhydrase 2	Rattus norvegicus	112-115
8804157-2	1996	In the presence of thapsigargin, a Ca(2+)-ATPase inhibitor of inositol (1, 4, 5) triphosphate (InsP3)-sensitive Ca2+ stores, caffeine caused an increase in [Ca2+]i, which was inhibited by treatment with ryanodine (a ligand to the Ca(2+)-induced Ca2+ release channels).	Caffeine	125-133	carbonic anhydrase 2	Rattus norvegicus	157-160
8804157-2	1996	In the presence of thapsigargin, a Ca(2+)-ATPase inhibitor of inositol (1, 4, 5) triphosphate (InsP3)-sensitive Ca2+ stores, caffeine caused an increase in [Ca2+]i, which was inhibited by treatment with ryanodine (a ligand to the Ca(2+)-induced Ca2+ release channels).	Caffeine	125-133	carbonic anhydrase 2	Rattus norvegicus	157-160
8866914-0	1996	Caffeine as a metabolic probe: NAT2 phenotyping.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	31-35
8866914-4	1996	N-acetyltransferase type 2 (NAT2) status was assessed in 23 young healthy subjects using both caffeine overnight and spot urine samples, and sulphadimidine.	Caffeine	94-102	N-acetyltransferase 2	Homo sapiens	0-26
8866914-4	1996	N-acetyltransferase type 2 (NAT2) status was assessed in 23 young healthy subjects using both caffeine overnight and spot urine samples, and sulphadimidine.	Caffeine	94-102	N-acetyltransferase 2	Homo sapiens	28-32
8833625-0	1996	Correspondence re: S. H. McQuilkin et al., analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-Acetyltransferase-2 activities.	Caffeine	83-91	N-acetyltransferase 2	Homo sapiens	149-170
8780250-8	1996	Finally, the cytosolic Ca2+ response to caffeine (5 x 10(-4) M), another RyR modulator, was also strongly attenuated by pretreatment with 5 x 10(-9) M ruthenium red.	Caffeine	40-48	ryanodine receptor 2	Rattus norvegicus	73-76
8641448-3	1996	Administration of 0.1-100 micromol/l MEL to voltage-clamped oocytes (holding potential: -70 mV) elicited oscillatory inward currents (reversal potential: -24 mV) which could be blocked by 9-anthracenecarboxylic acid and caffeine.	Caffeine	220-228	clone X2.0 melatonin receptor L homeolog	Xenopus laevis	37-40
8603609-7	1996	These results indicate that PACAP causes both Ca2+ release, mainly from caffeine-sensitive Ca2+ stores, and Ca2+ influx via L-type Ca2+ channels activated by membrane depolarization that depends on PKC-mediated Na+ influx.	Caffeine	72-80	adenylate cyclase activating polypeptide 1	Bos taurus	28-33
8728124-5	1996	The identified products indicate that the pertinent chemical reactions, i.e. C-8 hydroxylation, demethylations, and C8-N9 bond scission, are comparable to the primary metabolic pathways of caffeine in humans.	Caffeine	189-197	homeobox C8	Homo sapiens	77-80
8683457-18	1996	Introduction of Pi released Ca2+ from the SR. Ryanodine (100 microM) abolished caffeine-induced Ca2+ release while Pi-induced Ca2+ release was unaffected.	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	28-31
8779886-3	1996	Glucose uptake was blocked by acute (2-h) treatment with CPT, adenosine deaminase, or calphostin C. Caffeine (1 mM) or CPT (&gt; or = 0.1 mM) inhibited cell proliferation for the first 10 days, then cell growth assumed a normal proliferative rate despite continued presence of antagonist.	Caffeine	100-108	adenosine deaminase	Sus scrofa	62-81
8779886-4	1996	Cytosolic protein kinase C (PKC) beta-isoform immunoactivity and PKC-beta II mRNA were elevated at least twofold during 10 days of 0.1 mM CPT or 1 mM caffeine treatment.	Caffeine	150-158	protein kinase C beta type	Sus scrofa	10-37
8821550-15	1996	Treatment of the cells with caffeine (10 mM) produced similar inward currents to those produced by CPA.	Caffeine	28-36	carboxypeptidase A1, pancreatic	Mus musculus	99-102
8821550-16	1996	In the presence of caffeine, CPA (10 microM) induced no further inward current.	Caffeine	19-27	carboxypeptidase A1, pancreatic	Mus musculus	29-32
8683457-18	1996	Introduction of Pi released Ca2+ from the SR. Ryanodine (100 microM) abolished caffeine-induced Ca2+ release while Pi-induced Ca2+ release was unaffected.	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	96-99
8683457-5	1996	Application of 20 mM caffeine released Ca2+ from the sarcoplasmic reticulum (SR), resulting in a transient increase in the fura-2 fluorescence ratio.	Caffeine	21-29	carbonic anhydrase 2	Rattus norvegicus	39-42
8683457-6	1996	Caffeine-induced Ca2+ transients were smaller in the presence of 30 or 60 mM inorganic phosphate (Pi).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	17-20
8683457-18	1996	Introduction of Pi released Ca2+ from the SR. Ryanodine (100 microM) abolished caffeine-induced Ca2+ release while Pi-induced Ca2+ release was unaffected.	Caffeine	79-87	carbonic anhydrase 2	Rattus norvegicus	96-99
8683457-8	1996	Caffeine-induced Ca2+ transients were also reduced in the presence of 10 mM oxalate, although this effect was not reversed by CP.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	17-20
8683457-13	1996	The SR was Ca2+ depleted by withdrawal of ATP and exposure to 20 mM caffeine.	Caffeine	68-76	carbonic anhydrase 2	Rattus norvegicus	11-14
8683457-19	1996	Pi-induced Ca2+ release was reduced in the constant presence of 20 mM caffeine or 10 mM CP and was abolished completely by disruption of the SR membrane with Triton X-100.	Caffeine	70-78	carbonic anhydrase 2	Rattus norvegicus	11-14
8717354-0	1996	Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
8717354-10	1996	These findings suggest that glutamatergic transmission via NMDA receptors contributes to the induction of c-fos mRNA and NGFI-A mRNA by caffeine in striatum.	Caffeine	136-144	early growth response 1	Rattus norvegicus	121-127
8531542-10	1996	When glucose was lowered to 2.8 mmol/L, caffeine ingestion was associated with: greater awareness of hypoglycaemia in 9 patients, significantly more intense autonomic and neuroglycopenic symptoms, and higher levels of adrenaline, cortisol, and growth hormone.	Caffeine	40-48	growth hormone 1	Homo sapiens	244-258
8717354-0	1996	Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801.	Caffeine	0-8	early growth response 1	Rattus norvegicus	46-52
8717354-6	1996	The two NMDA receptor antagonists significantly reduced the caffeine-induced expression of both c-fos mRNA and NGFI-A mRNA in the medial part of the caudate putamen.	Caffeine	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
8717354-6	1996	The two NMDA receptor antagonists significantly reduced the caffeine-induced expression of both c-fos mRNA and NGFI-A mRNA in the medial part of the caudate putamen.	Caffeine	60-68	early growth response 1	Rattus norvegicus	111-117
8717354-10	1996	These findings suggest that glutamatergic transmission via NMDA receptors contributes to the induction of c-fos mRNA and NGFI-A mRNA by caffeine in striatum.	Caffeine	136-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
8653753-6	1996	The main supportive evidence is as follows: (a) an increased sensitivity to Ca2+ of the RyR of old muscle, and, more importantly; (b) an increased sensitivity to caffeine of [3H]ryanodine binding to the RyR at optimal Ca2+ and also optimal for the activity of the Ca(2+)-release channel.	Caffeine	162-170	ryanodine receptor 2	Rattus norvegicus	203-206
8653753-7	1996	The results reported here also demonstrate that there are two classes of caffeine sites in rat TA muscle, as defined by differences in EC50 values at resting (pCa 7) and at high Ca2+ (pCa 4-5), that sites involved in stimulation of [3H]-ryanodine binding to the RyR are distinguished by a higher affinity (caffeine below mM), and that only these sites undergo age-related changes.	Caffeine	73-81	ryanodine receptor 2	Rattus norvegicus	262-265
8625958-8	1996	In the white-ivory eye spot test, the three compounds (CRO, POC, and 2,4-D) with high recombinagenic activity and CAF were clearly nongenotoxic, whereas only ENU and NNP gave a positive response.	Caffeine	114-117	cro	Drosophila melanogaster	55-58
8896713-8	1996	In a second set, the D2 dopamine receptor antagonist, (-)-sulpiride, antagonized the enhancing effect of caffeine on memory.	Caffeine	105-113	dopamine receptor D2	Mus musculus	21-41
8866634-5	1996	CONCLUSION: Caffeine clearance, a simple, noninvasive test of CYP1A2 activity, is predictive of brofaromine clearance.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
9063913-8	1996	At hospital the high caffeine users showed the highest score on the factor depression (Hopkins Symptom Checklist; HSCL-58).	Caffeine	21-29	selenocysteine lyase	Homo sapiens	114-118
8857078-1	1996	OBJECTIVES: The biotransformation of caffeine has been studied in vitro using human cytochrome P-450 isoenzymes (CYPs) expressed in human B-lymphoblastoid cell lines, namely CYP1A1, 1A2, 2A6, 2B6, 2D6-Val, 2E1 and 3A4, and microsomal epoxide hydroxylase (EH).	Caffeine	37-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-100
8742516-5	1996	While the PARP-activity remained essentially unchanged, the acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited by 90-99%, when mice were injected additionally with the selective PARP-inhibitors nicotinic acid amide, benzamide, caffeine, theophyline, and thymidine, respectively.	Caffeine	270-278	glutamic pyruvic transaminase, soluble	Mus musculus	106-109
8857078-1	1996	OBJECTIVES: The biotransformation of caffeine has been studied in vitro using human cytochrome P-450 isoenzymes (CYPs) expressed in human B-lymphoblastoid cell lines, namely CYP1A1, 1A2, 2A6, 2B6, 2D6-Val, 2E1 and 3A4, and microsomal epoxide hydroxylase (EH).	Caffeine	37-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	174-180
8857078-6	1996	The affinity of caffeine for CYP1A1 was comparable to that of its homologue 1A2.	Caffeine	16-24	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
8857078-7	1996	CYP2D6-Met, which catalysed caffeine metabolism by demethylation and 8-hydroxylation, also had a relatively high intrinsic clearance (3.0 l center dot h-1 mmol-1 CYP), in particular for theophylline and paraxanthine formation, with kM values between 9-16 mmol center dot l-1.	Caffeine	28-36	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
8857078-7	1996	CYP2D6-Met, which catalysed caffeine metabolism by demethylation and 8-hydroxylation, also had a relatively high intrinsic clearance (3.0 l center dot h-1 mmol-1 CYP), in particular for theophylline and paraxanthine formation, with kM values between 9-16 mmol center dot l-1.	Caffeine	28-36	peptidylprolyl isomerase G	Homo sapiens	0-3
8857078-9	1996	In comparison, CYP2E1 played a less important role in in vitro caffeine metabolism.	Caffeine	63-71	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	15-21
8742516-5	1996	While the PARP-activity remained essentially unchanged, the acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited by 90-99%, when mice were injected additionally with the selective PARP-inhibitors nicotinic acid amide, benzamide, caffeine, theophyline, and thymidine, respectively.	Caffeine	270-278	poly (ADP-ribose) polymerase family, member 1	Mus musculus	221-225
8649208-9	1996	In addition, the amplitude of the [Ca2+]i transient gradually decreased after ryanodine and caffeine treatment.	Caffeine	92-100	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	35-38
8956502-5	1996	Caffeine reduced the peak of the Ca2+ concentration-response curve.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	33-36
8956502-7	1996	However, a further increase in Ca2+ sensitivity was observed even when 50 mmol.l-1 caffeine was added.	Caffeine	83-91	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	31-34
8956502-9	1996	Ca2+ sensitivity in ventricular skinned fibers obtained from carp was almost the same as that observed for the atrial, but the increase in Ca2+ sensitivity due to caffeine was larger.	Caffeine	163-171	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	0-3
8956502-9	1996	Ca2+ sensitivity in ventricular skinned fibers obtained from carp was almost the same as that observed for the atrial, but the increase in Ca2+ sensitivity due to caffeine was larger.	Caffeine	163-171	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	139-142
8706775-4	1996	We evaluated the CYP1A2 activity by the ratio of the molar urinary concentrations (CUM ratio) of the three end products of the paraxanthine demethylation of caffeine over the molar concentration of a paraxanthine 8-hydroxylation product.	Caffeine	157-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
8786710-7	1996	Pretreatment with AVP greatly reduced caffeine-induced Ca2+ release whereas pretreatment with caffeine also reduced AVP-induced Ca2+ release.	Caffeine	38-46	arginine vasopressin	Rattus norvegicus	18-21
8531066-3	1995	The evidence includes: 1) caffeine (1-33 mM)-induced concentration-dependent increase in the intracellular Ca++ concentration ([Ca++]i) in both the presence and absence of extracellular Ca++ and 2) although ryanodine alone (&lt; or = 10 microM) failed to change [Ca++]i, it inhibited the response to caffeine in a use-, concentration- and time-dependent manner.	Caffeine	26-34	carbonic anhydrase 1	Homo sapiens	128-134
8786710-7	1996	Pretreatment with AVP greatly reduced caffeine-induced Ca2+ release whereas pretreatment with caffeine also reduced AVP-induced Ca2+ release.	Caffeine	94-102	arginine vasopressin	Rattus norvegicus	116-119
8584430-4	1996	Treatment with caffeine occluded phase 2 ([Ca2+]i oscillations) of the action of thyrotropin-releasing hormone (TRH) without modifying phase 1 (Ca2+ release from the intracellular stores).	Caffeine	15-23	thyrotropin releasing hormone	Rattus norvegicus	81-110
8584430-4	1996	Treatment with caffeine occluded phase 2 ([Ca2+]i oscillations) of the action of thyrotropin-releasing hormone (TRH) without modifying phase 1 (Ca2+ release from the intracellular stores).	Caffeine	15-23	thyrotropin releasing hormone	Rattus norvegicus	112-115
8719260-2	1995	In the present study we have examined the contractile response to ET-1 in human placental arteries in the presence of several agents that interfere with storage of intracellular calcium, e.g. caffeine, ryanodine and thapsigargin.	Caffeine	192-200	endothelin 1	Homo sapiens	66-70
8719260-5	1995	Caffeine relaxed the basal tone of the vessels and reduced the contractile response to ET-1 by 51%.	Caffeine	0-8	endothelin 1	Homo sapiens	87-91
8962794-4	1995	The maternal intake of the caffeine diet increased Mn-superoxide dismutase (MnSOD) activity and Cu, Zn-superoxide dismutase (Cu,ZnSOD) in the heart of the pups.	Caffeine	27-35	superoxide dismutase 2	Rattus norvegicus	51-74
8962794-4	1995	The maternal intake of the caffeine diet increased Mn-superoxide dismutase (MnSOD) activity and Cu, Zn-superoxide dismutase (Cu,ZnSOD) in the heart of the pups.	Caffeine	27-35	superoxide dismutase 2	Rattus norvegicus	76-81
8962794-4	1995	The maternal intake of the caffeine diet increased Mn-superoxide dismutase (MnSOD) activity and Cu, Zn-superoxide dismutase (Cu,ZnSOD) in the heart of the pups.	Caffeine	27-35	superoxide dismutase 1	Rattus norvegicus	96-123
8962794-4	1995	The maternal intake of the caffeine diet increased Mn-superoxide dismutase (MnSOD) activity and Cu, Zn-superoxide dismutase (Cu,ZnSOD) in the heart of the pups.	Caffeine	27-35	superoxide dismutase 1	Rattus norvegicus	125-133
8962794-5	1995	On the other hand, the activity of Cu,ZnSOD was significantly reduced in the liver of pups whose dams consumed a caffeine, Zn, or caffeine plus Zn diet.	Caffeine	113-121	superoxide dismutase 1	Rattus norvegicus	35-43
8962794-5	1995	On the other hand, the activity of Cu,ZnSOD was significantly reduced in the liver of pups whose dams consumed a caffeine, Zn, or caffeine plus Zn diet.	Caffeine	130-138	superoxide dismutase 1	Rattus norvegicus	35-43
8791769-0	1996	Assays for CYP1A2 by testing in vivo metabolism of caffeine in humans.	Caffeine	51-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	11-17
8584440-4	1996	Furthermore, caffeine-induced hyperpolarization of the membrane is not detectable even in cells in which Ca2+ liberation from inositol 1,4,5-trisphosphate-sensitive compartments produces a prominent transient hyperpolarization in response to thyrotropin-releasing hormone.	Caffeine	13-21	thyrotropin releasing hormone	Rattus norvegicus	242-271
8584440-8	1996	We conclude that, as previously shown for thyrotropin-releasing hormone, modulation of inwardly rectifying K+ currents plays a major role determining the firing rate of GH3 cells and its enhancement by caffeine.	Caffeine	202-210	thyrotropin releasing hormone	Rattus norvegicus	42-71
8612969-10	1995	X. laevis oocytes deficient in IP3R, but expressing RyR1, were able to undergo progesterone-induced maturation with a time course comparable to that seen in wild-type oocytes when caffeine was used to activate RyR and induce intracellular calcium release.	Caffeine	180-188	inositol 1,4,5-trisphosphate receptor type 1 S homeolog	Xenopus laevis	31-35
8531066-3	1995	The evidence includes: 1) caffeine (1-33 mM)-induced concentration-dependent increase in the intracellular Ca++ concentration ([Ca++]i) in both the presence and absence of extracellular Ca++ and 2) although ryanodine alone (&lt; or = 10 microM) failed to change [Ca++]i, it inhibited the response to caffeine in a use-, concentration- and time-dependent manner.	Caffeine	26-34	carbonic anhydrase 1	Homo sapiens	263-269
8605948-4	1995	When caffeine was applied at the beginning of this fade of levcromakalim-induced relaxation in Rb-PSS its contractile effect was potentiated.	Caffeine	5-13	PSS	Homo sapiens	98-101
8847629-9	1995	Caffeine was able to produce a release of Ca2+ from the internal store of guinea-pig ureter and elicit contraction.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	42-45
8847629-0	1995	Major difference between rat and guinea-pig ureter in the ability of agonists and caffeine to release Ca2+ and influence force.	Caffeine	82-90	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	102-105
7592856-6	1995	In contrast to the parental host fibroblasts, sorcin transfectants displayed a rapid and transient rise in intracellular calcium in response to caffeine, suggesting organization of the accumulated ryanodine receptor protein into functional calcium release channels.	Caffeine	144-152	sorcin	Cricetulus griseus	46-52
8581475-3	1995	Both (1S,3S)-ACPD and D-CPPene dose-dependently increased the generalised seizure threshold in fully kindled animals.	Caffeine	5-12	homer scaffold protein 2	Homo sapiens	13-17
8581475-4	1995	They showed a similar potency, with (1S,3S)-ACPD acting presynaptically and D-CPPene postsynaptically.	Caffeine	36-43	homer scaffold protein 2	Homo sapiens	44-48
7586210-4	1995	On day 8, they were tested for CYP1A2 and NAT2 activity by caffeine phenotyping.	Caffeine	59-67	N-acetyltransferase 2	Homo sapiens	42-46
8655288-5	1995	In contrast, equal concentrations of caffeine increased chemiluminescence and MPO release with no effect on superoxide production.	Caffeine	37-45	myeloperoxidase	Homo sapiens	78-81
8574830-1	1995	The present study concerns the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha and of the anti-inflammatory cytokine IL-10 by human leukocytes in whole blood during stimulation with Streptococcus pneumoniae and the effects of various xanthine derivates, i.e., pentoxifylline (PTX), caffeine, and theofylline, and of dexamethasone (DXM).	Caffeine	338-346	interleukin 10	Homo sapiens	173-178
8574830-4	1995	The release of IL-10 was significantly reduced by PTX at 24 h and by caffeine at 48 h, but DXM increased the release of this cytokine.	Caffeine	69-77	interleukin 10	Homo sapiens	15-20
8567752-8	1995	In addition, immunofluorescent microscopy showed that individual cells overexpressing cyclin B1 during S phase arrest underwent PCC when exposed to caffeine.	Caffeine	148-156	cyclin B1	Homo sapiens	86-95
7548239-0	1995	Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus.	Caffeine	58-66	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-27
7472512-0	1995	Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration.	Caffeine	119-127	early growth response 1	Rattus norvegicus	69-75
7472512-0	1995	Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration.	Caffeine	119-127	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	80-86
7472512-1	1995	The time course of expression of mRNA for NGFI-A and NGFI-B after a single intraperitoneal injection of saline or caffeine was examined using in situ hybridization.	Caffeine	114-122	early growth response 1	Rattus norvegicus	42-48
7472512-1	1995	The time course of expression of mRNA for NGFI-A and NGFI-B after a single intraperitoneal injection of saline or caffeine was examined using in situ hybridization.	Caffeine	114-122	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	53-59
7472512-2	1995	Administration of a high dose of caffeine (100 mg/kg) decreased locomotor behavior and increased NGFI-A and NGFI-B mRNA in the entire striatum.	Caffeine	33-41	early growth response 1	Rattus norvegicus	97-103
7472512-2	1995	Administration of a high dose of caffeine (100 mg/kg) decreased locomotor behavior and increased NGFI-A and NGFI-B mRNA in the entire striatum.	Caffeine	33-41	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	108-114
7472512-7	1995	The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).	Caffeine	61-69	early growth response 1	Rattus norvegicus	25-31
7472512-7	1995	The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).	Caffeine	61-69	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	33-39
7548239-4	1995	Immunoblot analysis revealed that caffeine gave rise to a dose-dependent increase in the hepatic CYP1A2, and at the highest dose only, CYP2B apoprotein levels.	Caffeine	34-42	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	97-103
7548239-8	1995	Molecular modelling revealed that the caffeine molecule could orientate itself within the putative CYP1A2 active site so as to facilitate demethylation of the N-1, N-3 and N-7 positions.	Caffeine	38-46	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	99-105
7548239-10	1995	In conclusion caffeine, being essentially planar, is an inducer of CYP1A2 in rat liver.	Caffeine	14-22	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	67-73
8562120-12	1995	In the present study P450 1A2 activity was estimated from the caffeine metabolic ratio, the so-called CYP 1A2 index:(AFMU + 1-MX + 1-MU/ 17 -DMU) of the caffeine metabolites formed after oral ingestion of 200 mg caffeine.	Caffeine	62-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-109
8576853-9	1995	The rates of Ca2+ removal in the presence of caffeine, which reflect primarily the Ca2+ extruding activity of the Na(+)-Ca2+ exchanger, followed the same order of hamster &gt; guinea-pig &gt; or = human &gt; or = rat.	Caffeine	45-53	solute carrier family 8 member A1	Homo sapiens	114-134
8562120-12	1995	In the present study P450 1A2 activity was estimated from the caffeine metabolic ratio, the so-called CYP 1A2 index:(AFMU + 1-MX + 1-MU/ 17 -DMU) of the caffeine metabolites formed after oral ingestion of 200 mg caffeine.	Caffeine	153-161	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-109
8562120-12	1995	In the present study P450 1A2 activity was estimated from the caffeine metabolic ratio, the so-called CYP 1A2 index:(AFMU + 1-MX + 1-MU/ 17 -DMU) of the caffeine metabolites formed after oral ingestion of 200 mg caffeine.	Caffeine	153-161	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-109
8563766-2	1995	In addition, CYP1A2 contributes to the inactivation of several common drugs and dietary constituents, including acetaminophen and caffeine.	Caffeine	130-138	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
7565726-6	1995	Although rlm1 delta cells grow normally at any temperature, they display a caffeine-sensitive phenotype similar to that observed in mutants defective in BCK1, MKK1/MKK2, or MPK1.	Caffeine	75-83	Rlm1p	Saccharomyces cerevisiae S288C	9-13
8546870-5	1995	Caffeine (10 mM) induced a single transient inward current and prevented any further activation of inward current, or enhancement of Iout, by subsequent application of 16 nM ET-1, suggesting that these currents were mediated by Ca2+ release from internal stores.	Caffeine	0-8	endothelin 1	Rattus norvegicus	174-178
7562626-5	1995	This phenomenon is termed RISC (repolarization-induced stop of caffeine-induced Ca2+ release).	Caffeine	63-71	serine carboxypeptidase 1	Rattus norvegicus	26-30
7473240-4	1995	Caffeine caused a transient increase in [Ca2+]i in the somata and dendrites of Purkinje neurones.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	41-44
7473240-5	1995	Caffeine-induced Ca2+ transients were not associated with a membrane inward current and persisted in Ca(2+)-free external solutions, indicating that they are caused by Ca2+ released from intracellular stores.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	17-20
7473240-5	1995	Caffeine-induced Ca2+ transients were not associated with a membrane inward current and persisted in Ca(2+)-free external solutions, indicating that they are caused by Ca2+ released from intracellular stores.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	168-171
7473240-6	1995	The amplitudes of the caffeine-mediated elevations in [Ca2+]i were strongly dependent on the baseline level of [Ca2+]i.	Caffeine	22-30	carbonic anhydrase 2	Rattus norvegicus	55-58
7473240-6	1995	The amplitudes of the caffeine-mediated elevations in [Ca2+]i were strongly dependent on the baseline level of [Ca2+]i.	Caffeine	22-30	carbonic anhydrase 2	Rattus norvegicus	112-115
7473240-8	1995	Intracellular application of Ruthenium Red through the patch pipette blocked caffeine-induced Ca2+ transients in Purkinje neurones.	Caffeine	77-85	carbonic anhydrase 2	Rattus norvegicus	94-97
7473240-9	1995	Ryanodine when applied either intra- or extracellularly caused a use-dependent block of caffeine-induced Ca2+ release.	Caffeine	88-96	carbonic anhydrase 2	Rattus norvegicus	105-108
7473240-11	1995	Depolarization-induced Ca2+ transients were strongly prolonged by caffeine.	Caffeine	66-74	carbonic anhydrase 2	Rattus norvegicus	23-26
7473240-16	1995	Dendritic Ca2+ transients produced by stimulation of the excitatory climbing fibre synaptic input were also prolonged by caffeine, indicating that ryanodine receptor-mediated release of Ca2+ may be involved in synaptic signalling in cerebellar Purkinje neurones.	Caffeine	121-129	carbonic anhydrase 2	Rattus norvegicus	10-13
7473240-16	1995	Dendritic Ca2+ transients produced by stimulation of the excitatory climbing fibre synaptic input were also prolonged by caffeine, indicating that ryanodine receptor-mediated release of Ca2+ may be involved in synaptic signalling in cerebellar Purkinje neurones.	Caffeine	121-129	carbonic anhydrase 2	Rattus norvegicus	186-189
7473240-18	1995	Ryanodine receptor-mediated release of Ca2+ in cerebellar Purkinje neurones can be explained by a model in which release of Ca2+ is strongly facilitated by the co-operative action of Ca2+, caffeine and/or ryanodine.	Caffeine	189-197	carbonic anhydrase 2	Rattus norvegicus	39-42
7473240-18	1995	Ryanodine receptor-mediated release of Ca2+ in cerebellar Purkinje neurones can be explained by a model in which release of Ca2+ is strongly facilitated by the co-operative action of Ca2+, caffeine and/or ryanodine.	Caffeine	189-197	carbonic anhydrase 2	Rattus norvegicus	124-127
7473240-18	1995	Ryanodine receptor-mediated release of Ca2+ in cerebellar Purkinje neurones can be explained by a model in which release of Ca2+ is strongly facilitated by the co-operative action of Ca2+, caffeine and/or ryanodine.	Caffeine	189-197	carbonic anhydrase 2	Rattus norvegicus	124-127
7587963-10	1995	Induction of monkey CYP1A1/2 was associated with a marked increase in the O-dealkylation of 7-methoxyresorufin (up to 65-fold), the O-dealkylation of 7-ethoxyresorufin (up to 30-fold), and the N3-demethylation of caffeine (up to 17-fold), but only a 2-fold increase in benzo[a]pyrene 3-hydroxylation.	Caffeine	213-221	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	20-26
7587963-11	1995	Polyclonal antibodies against CYP1A1 markedly inhibited the N3-demethylation of caffeine and the O-dealkylation of 7-methoxy- and 7-ethoxyresorufin by liver microsomes from beta-naphthoflavone-treated monkeys, and partially inhibited the 3-hydroxylation of benzo[a]pyrene, indicating that monkey CYP1A1 and/or CYP1A2, like the corresponding rat enzymes, can catalyze all four reactions.	Caffeine	80-88	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-36
7781267-6	1995	A combined mephenytoin, sparteine, and caffeine test performed before, during, and after multiple dosing of moclobemide showed changes in the metabolic indexes compatible with a reversible inhibition of oxidation by way of the corresponding CYP enzymes--CYP2C19, CYP2D6, and CYP1A2--during moclobemide treatment.	Caffeine	39-47	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	254-261
7576041-1	1995	Prior studies have shown that in younger depressives undergoing ECT whose seizure durations declined despite maximum settings on three different ECT devices, pretreatment with caffeine lengthened seizures and resulted in clinical improvement.	Caffeine	176-184	ECT	Homo sapiens	64-67
7576041-1	1995	Prior studies have shown that in younger depressives undergoing ECT whose seizure durations declined despite maximum settings on three different ECT devices, pretreatment with caffeine lengthened seizures and resulted in clinical improvement.	Caffeine	176-184	ECT	Homo sapiens	145-148
7576041-3	1995	The purpose of this retrospective study was to determine the safety and efficacy of caffeine augmented ECT in elderly depressed patients.	Caffeine	84-92	ECT	Homo sapiens	103-106
7576041-4	1995	The charts of 14 elderly depressives (average age 75.6, range 59-83; 2 males, 12 females) who received caffeine-augmented ECT were reviewed.	Caffeine	103-111	ECT	Homo sapiens	122-125
7576041-10	1995	We conclude from this study that caffeine-augmented ECT is safe and effective in increasing seizure duration in the elderly.	Caffeine	33-41	ECT	Homo sapiens	52-55
8578993-0	1995	Increased effects of topically applied interferon on herpes simplex virus-induced lesions by caffeine.	Caffeine	93-101	interferon alpha 1	Homo sapiens	39-49
7576041-0	1995	Safety and efficacy of caffeine-augmented ECT in elderly depressives: a retrospective study.	Caffeine	23-31	ECT	Homo sapiens	42-45
7781267-6	1995	A combined mephenytoin, sparteine, and caffeine test performed before, during, and after multiple dosing of moclobemide showed changes in the metabolic indexes compatible with a reversible inhibition of oxidation by way of the corresponding CYP enzymes--CYP2C19, CYP2D6, and CYP1A2--during moclobemide treatment.	Caffeine	39-47	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	263-269
7781267-6	1995	A combined mephenytoin, sparteine, and caffeine test performed before, during, and after multiple dosing of moclobemide showed changes in the metabolic indexes compatible with a reversible inhibition of oxidation by way of the corresponding CYP enzymes--CYP2C19, CYP2D6, and CYP1A2--during moclobemide treatment.	Caffeine	39-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	275-281
7791341-8	1995	Lesser degrees of CGRP release were observed after nonspecific stimulation with K+ or phosphodiesterase inhibition with caffeine.	Caffeine	120-128	calcitonin related polypeptide alpha	Homo sapiens	18-22
7728998-10	1995	INSC activated with O-Rs, oxidizing agents, or caffeine was sensitive to SK&amp;F 96365.	Caffeine	47-55	protein inscuteable homolog	Cavia porcellus	0-4
7479582-7	1995	Propylene glycol inhibited the activity of CYP2E1 as indicated by 84% reduction in the clearance of 3 mg/kg dose of chlorzoxazone, whereas fluvoxamine inhibited the activity of CYP1A2 as indicated by 40% reduction in the clearance of a 10 mg/kg dose of caffeine.	Caffeine	253-261	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	43-49
7479582-7	1995	Propylene glycol inhibited the activity of CYP2E1 as indicated by 84% reduction in the clearance of 3 mg/kg dose of chlorzoxazone, whereas fluvoxamine inhibited the activity of CYP1A2 as indicated by 40% reduction in the clearance of a 10 mg/kg dose of caffeine.	Caffeine	253-261	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	177-183
7539257-0	1995	Caffeine inhibits the binding of thyrotropin-releasing hormone in GH4C1 pituitary cells.	Caffeine	0-8	thyrotropin releasing hormone	Rattus norvegicus	33-62
7539257-2	1995	In the present study we show that in Fura 2 loaded GH4C1 cells, caffeine inhibited, in a dose-dependent manner, the Ca2+ response induced by a submaximally effective dose (3 nM) of thyrotropin-releasing hormone (TRH).	Caffeine	64-72	thyrotropin releasing hormone	Rattus norvegicus	181-210
7539257-2	1995	In the present study we show that in Fura 2 loaded GH4C1 cells, caffeine inhibited, in a dose-dependent manner, the Ca2+ response induced by a submaximally effective dose (3 nM) of thyrotropin-releasing hormone (TRH).	Caffeine	64-72	thyrotropin releasing hormone	Rattus norvegicus	212-215
7539257-3	1995	We also show that caffeine decreased the specific binding of [3H]TRH.	Caffeine	18-26	thyrotropin releasing hormone	Rattus norvegicus	65-68
7661457-10	1995	Milk caffeine concentration was similar to serum concentration 1.5 to 24 hours after caffeine administration.	Caffeine	5-13	Weaning weight-maternal milk	Bos taurus	0-4
7539257-4	1995	Equilibrium binding studies with [3H]TRH and Scatchard analysis of the binding data showed that caffeine increased the dissociation constant (Kd) from 8 +/- 1 nM to 26 +/- 3 nM, while the maximum amount of [3H]TRH bound to the cells was increased by 32%.	Caffeine	96-104	thyrotropin releasing hormone	Rattus norvegicus	37-40
7539257-4	1995	Equilibrium binding studies with [3H]TRH and Scatchard analysis of the binding data showed that caffeine increased the dissociation constant (Kd) from 8 +/- 1 nM to 26 +/- 3 nM, while the maximum amount of [3H]TRH bound to the cells was increased by 32%.	Caffeine	96-104	thyrotropin releasing hormone	Rattus norvegicus	210-213
7539257-5	1995	Thus, caffeine inhibited the TRH-evoked increase in [Ca2+]i by inhibiting the binding of TRH to its receptor.	Caffeine	6-14	thyrotropin releasing hormone	Rattus norvegicus	29-32
7539257-5	1995	Thus, caffeine inhibited the TRH-evoked increase in [Ca2+]i by inhibiting the binding of TRH to its receptor.	Caffeine	6-14	thyrotropin releasing hormone	Rattus norvegicus	89-92
7572198-1	1995	It has previously been shown that caffeine, in a dose-dependent manner, increases the expression of the protooncogene c-fos in the rat brain, predominantly in the caudate-putamen and tuberculum olfactorium.	Caffeine	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	118-123
7572198-5	1995	Thus, c-fos is induced in rat striatum following administration of caffeine and other xanthines that (provided they enter the brain) block adenosine receptors, suggesting an involvement of central adenosine receptors.	Caffeine	67-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	6-11
7728998-11	1995	O-R treatment was without effect when INSC was already activated with caffeine.	Caffeine	70-78	protein inscuteable homolog	Cavia porcellus	38-42
7751931-0	1995	Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.	Caffeine	117-125	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-35
7751931-0	1995	Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.	Caffeine	117-125	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-41
7751931-1	1995	The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.	Caffeine	36-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-71
7751931-1	1995	The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.	Caffeine	36-44	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-84
7751931-1	1995	The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.	Caffeine	36-44	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-94
7751931-4	1995	By using in situ hybridization of adjacent sections we found a rapid, transient, and dose-dependent increase of c-fos, c-jun, and junB by caffeine in striatum, especially in the lateral part.	Caffeine	138-146	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
7650844-7	1995	30 mM of caffeine, 5 microM of norepinephrine or 10 microM of IP3 resulted in greater increases in the rates of Ca2+ efflux in WKY than in SHR aortic strips.	Caffeine	9-17	carbonic anhydrase 2	Rattus norvegicus	112-115
7751931-4	1995	By using in situ hybridization of adjacent sections we found a rapid, transient, and dose-dependent increase of c-fos, c-jun, and junB by caffeine in striatum, especially in the lateral part.	Caffeine	138-146	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-134
7751931-8	1995	Furthermore, by using gel shift assay we found an induction of AP-1 by caffeine (100 mg/kg) in striatum, which peaked 2 hr after administration and was clearly increased after 4 hr.	Caffeine	71-79	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-67
7751931-12	1995	The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.	Caffeine	36-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
7751931-12	1995	The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.	Caffeine	36-44	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-128
7751931-12	1995	The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.	Caffeine	36-44	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	163-167
7623275-7	1995	Tetracaine (10 microM to 2 mM) inhibited in a concentration-dependent manner the Ca(2+)-induced Ca2+ release (CICR) evoked by 5 mM caffeine.	Caffeine	131-139	carbonic anhydrase 2	Rattus norvegicus	96-99
7493606-0	1995	Caffeine and carbachol act on common Ca2+ stores to release Ca2+ in guinea-pig ileal smooth muscle.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	37-40
7493606-0	1995	Caffeine and carbachol act on common Ca2+ stores to release Ca2+ in guinea-pig ileal smooth muscle.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	60-63
7493606-2	1995	Caffeine (20 mM), carbachol (10 or 100 microM) or IP3 (40 microM), applied after loading Ca2+ within intracellular stores, produced a transient rise in tension in a Ca(2+)-free solution.	Caffeine	0-8	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	89-92
7493606-6	1995	The effects of carbachol and IP3 were abolished after combined treatment with ryanodine (30 microM) and caffeine (20 mM) which causes functional removal of caffeine-releasable Ca2+ stores, but not after combined treatment with ryanodine (30 microM) and carbachol (10 microM).	Caffeine	104-112	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	176-179
7493606-6	1995	The effects of carbachol and IP3 were abolished after combined treatment with ryanodine (30 microM) and caffeine (20 mM) which causes functional removal of caffeine-releasable Ca2+ stores, but not after combined treatment with ryanodine (30 microM) and carbachol (10 microM).	Caffeine	156-164	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	176-179
7493606-7	1995	The results suggest that caffeine, carbachol and IP3 all act on common Ca2+ stores to release Ca2+.	Caffeine	25-33	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	71-74
7493606-7	1995	The results suggest that caffeine, carbachol and IP3 all act on common Ca2+ stores to release Ca2+.	Caffeine	25-33	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	94-97
7606345-10	1995	Both the contractions induced directly by caffeine and those produced following caffeine wash-out after ryanodine treatment were accompanied by a maintained increase in intracellular Ca2+ concentration measured with fura-2.	Caffeine	42-50	carbonic anhydrase 2	Oryctolagus cuniculus	183-186
7712468-0	1995	Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay.	Caffeine	55-63	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	28-31
7712468-0	1995	Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay.	Caffeine	55-63	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	39-42
7712468-5	1995	At low doses (500 microM), caffeine caused selective radiosensitization in the p53(-) cells.	Caffeine	27-35	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	79-82
7712468-7	1995	At higher doses (2 mM caffeine), where sensitization was seen in both p53(+) and p53(-) cells, the radiosensitization and the G2-M override were more pronounced in the p53(-) cells.	Caffeine	22-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	70-73
7712468-7	1995	At higher doses (2 mM caffeine), where sensitization was seen in both p53(+) and p53(-) cells, the radiosensitization and the G2-M override were more pronounced in the p53(-) cells.	Caffeine	22-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	81-84
7712468-7	1995	At higher doses (2 mM caffeine), where sensitization was seen in both p53(+) and p53(-) cells, the radiosensitization and the G2-M override were more pronounced in the p53(-) cells.	Caffeine	22-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	81-84
7712468-8	1995	The greater caffeine-induced radiosensitization in p53(-) cells suggests that p53, already shown to control the G1-S checkpoint, may also influence aspects of G2-M arrest.	Caffeine	12-20	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	51-54
7712468-8	1995	The greater caffeine-induced radiosensitization in p53(-) cells suggests that p53, already shown to control the G1-S checkpoint, may also influence aspects of G2-M arrest.	Caffeine	12-20	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	78-81
7606345-10	1995	Both the contractions induced directly by caffeine and those produced following caffeine wash-out after ryanodine treatment were accompanied by a maintained increase in intracellular Ca2+ concentration measured with fura-2.	Caffeine	80-88	carbonic anhydrase 2	Oryctolagus cuniculus	183-186
7606345-14	1995	It is concluded that caffeine can induce a sustained contraction after ryanodine treatment both in the guinea-pig gastric antrum and rabbit portal vein, by activating a Ca2+ influx pathway insensitive to organic Ca2+ channel blockers.	Caffeine	21-29	carbonic anhydrase 2	Oryctolagus cuniculus	169-172
7606345-4	1995	The caffeine-induced contraction was abolished by removal of the external Ca2+ more rapidly in the gastric antrum than the portal vein.	Caffeine	4-12	carbonic anhydrase 2	Oryctolagus cuniculus	74-77
7606345-14	1995	It is concluded that caffeine can induce a sustained contraction after ryanodine treatment both in the guinea-pig gastric antrum and rabbit portal vein, by activating a Ca2+ influx pathway insensitive to organic Ca2+ channel blockers.	Caffeine	21-29	carbonic anhydrase 2	Oryctolagus cuniculus	212-215
7606345-16	1995	A hypothesis is proposed that the plasma membrane of these preparations is similar to the sarcoplasmic reticulum membrane in that Ca2+permeability can be increased almost irreversibly by a combination of caffeine and ryanodine in the presence of the external Ca2+.	Caffeine	204-212	carbonic anhydrase 2	Oryctolagus cuniculus	130-133
7606345-16	1995	A hypothesis is proposed that the plasma membrane of these preparations is similar to the sarcoplasmic reticulum membrane in that Ca2+permeability can be increased almost irreversibly by a combination of caffeine and ryanodine in the presence of the external Ca2+.	Caffeine	204-212	carbonic anhydrase 2	Oryctolagus cuniculus	259-262
7643157-11	1995	Caffeine (2 mM) also reversibly blocked PICs; this effect was independent from adenosine 3",5"-cyclic monophosphate (cAMP) accumulation, inhibition of voltage-dependent Ca2+ current, or blockade of adenosine receptors.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	169-172
7540139-2	1995	IO, but not INS, failed to be reproduced in Ca(2+)-free solution and was markedly reduced by prior exposure to caffeine under Ca(2+)-free conditions or by addition to normal solution of cyclopiazonic acid (CPA), a Ca2+ ATPase inhibitor.	Caffeine	111-119	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	214-225
7663531-1	1995	The first steps in the metabolism of caffeine and chlorzoxazone are primarily catalysed by CYP1A2 and CYP2E1, respectively.	Caffeine	37-45	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-97
7663531-1	1995	The first steps in the metabolism of caffeine and chlorzoxazone are primarily catalysed by CYP1A2 and CYP2E1, respectively.	Caffeine	37-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	102-108
7663531-6	1995	CYP1A2 activity was determined either by the paraxanthine/caffeine ratio in the blood or by the usual caffeine metabolic ratio in the urine.	Caffeine	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
7663531-6	1995	CYP1A2 activity was determined either by the paraxanthine/caffeine ratio in the blood or by the usual caffeine metabolic ratio in the urine.	Caffeine	102-110	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
7663531-10	1995	In contrast, an inhibition of CYP1A2 by chlorzoxazone was demonstrated by a 16% decrease in the caffeine metabolic ratio in urine when both caffeine and chlorzoxazone were given together.	Caffeine	96-104	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-36
7663531-10	1995	In contrast, an inhibition of CYP1A2 by chlorzoxazone was demonstrated by a 16% decrease in the caffeine metabolic ratio in urine when both caffeine and chlorzoxazone were given together.	Caffeine	140-148	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-36
7890648-6	1995	Mobilization of both caffeine- and inositol trisphosphate-sensitive intracellular Ca2+ stores is found to elicit secretion with or without extracellular Ca2+.	Caffeine	21-29	carbonic anhydrase 2	Bos taurus	82-85
7890648-7	1995	Caffeine-sensitive intracellular Ca2+ stores can be depleted, refilled, and cause exocytosis in medium without Ca2+.	Caffeine	0-8	carbonic anhydrase 2	Bos taurus	33-36
7742721-0	1995	Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-101
7540095-4	1995	In Ca2+ electrode experiments, DBHC (100 microM) markedly inhibited Ca2+ release from the heavy fraction of sarcoplasmic reticulum (HSR) induced by caffeine (1 mM) and BED (10 microM).	Caffeine	148-156	HSR	Homo sapiens	132-135
7540095-8	1995	DBHC (100 microM) abolished 45Ca2+ release induced by caffeine (1 mM) and BED (10 microM) in HSR.	Caffeine	54-62	HSR	Homo sapiens	93-96
7540095-15	1995	[3H]-ryanodine binding to HSR was enhanced by caffeine and BED.	Caffeine	46-54	HSR	Homo sapiens	26-29
7540095-21	1995	These results suggest that DBHC binds to the caffeine binding site to block Ca2+ release from HSR.	Caffeine	45-53	HSR	Homo sapiens	94-97
7742721-0	1995	Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.	Caffeine	40-48	N-acetyltransferase 2	Homo sapiens	106-127
7864219-2	1995	The SR Ca2+ load was graded by the duration of conditioning voltage-clamp steps and verified by caffeine-dependent Ca2+i transients.	Caffeine	96-104	carbonic anhydrase 2	Rattus norvegicus	7-10
7742721-2	1995	Previous reports have determined CYP1A2 and NAT2 phenotypes by quantitating relative amounts of urinary caffeine and metabolites.	Caffeine	104-112	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
7742721-2	1995	Previous reports have determined CYP1A2 and NAT2 phenotypes by quantitating relative amounts of urinary caffeine and metabolites.	Caffeine	104-112	N-acetyltransferase 2	Homo sapiens	44-48
7774672-4	1995	On the contrary, the analogues which have a carbazole skeleton and bromine at C-6 inhibit both Ca(2+)- and caffeine-induced Ca2+ release.	Caffeine	107-115	complement C6	Homo sapiens	78-81
7864219-2	1995	The SR Ca2+ load was graded by the duration of conditioning voltage-clamp steps and verified by caffeine-dependent Ca2+i transients.	Caffeine	96-104	carbonic anhydrase 2	Rattus norvegicus	115-118
7864219-4	1995	Changes in the amplitudes of Ca2+i transients elicited by ICa and changes in the gain index were linearly correlated (r2 = 0.83 and 0.79, respectively; P &lt; 0.001 for each) with changes in amplitudes of Ca2+i transients elicited by caffeine pulses applied in lieu of the respective voltage-clamp pulses.	Caffeine	234-242	carbonic anhydrase 2	Rattus norvegicus	29-32
7864219-4	1995	Changes in the amplitudes of Ca2+i transients elicited by ICa and changes in the gain index were linearly correlated (r2 = 0.83 and 0.79, respectively; P &lt; 0.001 for each) with changes in amplitudes of Ca2+i transients elicited by caffeine pulses applied in lieu of the respective voltage-clamp pulses.	Caffeine	234-242	carbonic anhydrase 2	Rattus norvegicus	205-208
7714686-1	1995	To evaluate its clinical value, the half-life of caffeine (1,3,7-trimethylxanthine) in saliva (SCT) after 3 mg/kg-1 oral caffeine was measured in 53 children with chronic liver disease (mean age, 4.41 years) and 48 control children (mean age, 6.26 years) in five samples over 24 h and compared with parameters of liver function and outcome.	Caffeine	49-57	secretin	Homo sapiens	95-98
7883225-0	1995	Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-42
7714686-1	1995	To evaluate its clinical value, the half-life of caffeine (1,3,7-trimethylxanthine) in saliva (SCT) after 3 mg/kg-1 oral caffeine was measured in 53 children with chronic liver disease (mean age, 4.41 years) and 48 control children (mean age, 6.26 years) in five samples over 24 h and compared with parameters of liver function and outcome.	Caffeine	59-82	secretin	Homo sapiens	95-98
7488258-6	1995	The caffeine effect appeared to be significantly augmented (by about 15%, P &lt; 0.02) under exposure to burst-type pulsed microwaves (pulse width, 1.5 msec; pause, 2.5 msec; 8 pulses/burst, 16 bursts/s; average SAR, 8-10 W/kg).	Caffeine	4-12	sarcosine dehydrogenase	Homo sapiens	212-215
7756101-0	1995	Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-89
7756101-2	1995	Caffeine is widely used as an in vivo probe for CYP1A2; the distribution/activity of this enzyme is reported to be reflected by metabolic ratios.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	48-54
7756101-11	1995	Data in the literature claiming to measure CYP1A2 using caffeine may reflect other parameters.	Caffeine	56-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
7828378-1	1995	Caffeine is increasingly used as a biochemical probe for liver function, in cancer epidemiology, and in pharmacogenetics, with its recognized ability to assess the activities of CYP1A2, xanthine oxidase, and N-acetyltransferase-2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	178-184
7587619-4	1995	A third type of [Ca2+]i oscillation is typified by caffeine-induced oscillations in sympathetic neurons.	Caffeine	51-59	carbonic anhydrase 2	Homo sapiens	17-20
7587619-5	1995	Here, the oscillations depend on the interplay between Ca2+ transport across the plasma membrane and transport by a caffeine-sensitive store.	Caffeine	116-124	carbonic anhydrase 2	Homo sapiens	55-58
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	38-41
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	20-28	carbonic anhydrase 2	Homo sapiens	87-90
7828378-1	1995	Caffeine is increasingly used as a biochemical probe for liver function, in cancer epidemiology, and in pharmacogenetics, with its recognized ability to assess the activities of CYP1A2, xanthine oxidase, and N-acetyltransferase-2.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	208-229
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	38-41
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7816617-4	1994	However, the hac1 disruptant becomes caffeine sensitive, which is suppressed by multicopy expression of the yeast PDE2 (Phosphodiesterase 2) gene.	Caffeine	37-45	transcription factor HAC1	Saccharomyces cerevisiae S288C	13-17
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-8	1995	It is proposed that caffeine-induced [Ca2+]i oscillations are cyclic perturbations of [Ca2+]i caused by exchange of Ca2+ between the cytosol and the caffeine-sensitive store: net Ca2+ loss from the store increases [Ca2+]i transiently above its steady-state value ([Ca2+]ss), whereas net accumulation of Ca2+ by the store transiently depresses [Ca2+]i below [Ca2+]ss.	Caffeine	149-157	carbonic anhydrase 2	Homo sapiens	87-90
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	151-159	carbonic anhydrase 2	Homo sapiens	32-35
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	151-159	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	151-159	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	151-159	carbonic anhydrase 2	Homo sapiens	76-79
7587619-9	1995	The effects of rapid removal of Ca2+ and caffeine on the rate of change of [Ca2+]i (d[Ca2+]i/dt) provide estimates of the rates of net Ca2+ entry and (caffeine-sensitive) Ca2+ release and information on the way these rates vary during the oscillatory cycle.	Caffeine	151-159	carbonic anhydrase 2	Homo sapiens	76-79
7720764-0	1995	A population and family study of CYP1A2 using caffeine urinary metabolites.	Caffeine	46-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
7581492-7	1995	In order to determine the presence of and frequency of genetic polymorphisms of CYP1A2 and NAT2 in humans, we performed in caffeine phenotyping test on 205 Japanese volunteers.	Caffeine	123-131	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
7838717-7	1994	Several caffeine up-regulated clones were obtained from the pre-B cell line 1-8, including IGF-1B, and a predicted homologue of the natural killer cell antigen, NKR-P1.	Caffeine	8-16	killer cell lectin like receptor B1	Homo sapiens	161-167
8846619-2	1995	Cytochrome P450 1A2 (CYP1A2) accounts for about 10 to 15% of the total CYP content of human liver and is the major enzyme involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine.	Caffeine	206-214	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19
8846619-2	1995	Cytochrome P450 1A2 (CYP1A2) accounts for about 10 to 15% of the total CYP content of human liver and is the major enzyme involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine.	Caffeine	206-214	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
8846619-2	1995	Cytochrome P450 1A2 (CYP1A2) accounts for about 10 to 15% of the total CYP content of human liver and is the major enzyme involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine.	Caffeine	206-214	peptidylprolyl isomerase G	Homo sapiens	21-24
21556506-4	1995	CAFF caused a moderate increase of P-170 (12 to 36 h) and of GST-pi (6 to 72 h).	Caffeine	0-4	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	35-40
21556506-8	1995	Only a moderate increase of c-FOS was seen after exposure to CAFF.	Caffeine	61-65	FBJ osteosarcoma oncogene	Mus musculus	28-33
21556506-9	1995	Five out of seven additionally investigated rodent cell lines showed an increase in the expression of P-170, GST-pi and c-FOS after exposure to DOX, EtOH or CAFF.	Caffeine	157-161	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	102-107
21556506-9	1995	Five out of seven additionally investigated rodent cell lines showed an increase in the expression of P-170, GST-pi and c-FOS after exposure to DOX, EtOH or CAFF.	Caffeine	157-161	FBJ osteosarcoma oncogene	Mus musculus	120-125
7622978-7	1995	The adequate serum levels of vitamin B12 and folic acid might be the result of the habit of the workers to consume tonic drinks which contain glucose, caffeine, and vitamins especially vitamins B6, and B12.	Caffeine	151-159	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
7803452-0	1994	Caffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPase.	Caffeine	0-8	dynein axonemal heavy chain 8	Homo sapiens	148-154
7816617-4	1994	However, the hac1 disruptant becomes caffeine sensitive, which is suppressed by multicopy expression of the yeast PDE2 (Phosphodiesterase 2) gene.	Caffeine	37-45	3',5'-cyclic-nucleotide phosphodiesterase PDE2	Saccharomyces cerevisiae S288C	114-118
7816617-4	1994	However, the hac1 disruptant becomes caffeine sensitive, which is suppressed by multicopy expression of the yeast PDE2 (Phosphodiesterase 2) gene.	Caffeine	37-45	3',5'-cyclic-nucleotide phosphodiesterase PDE2	Saccharomyces cerevisiae S288C	120-139
7723472-0	1994	Caffeine-induced increase of adenosine deaminase activity in mammalian lymphoid organs.	Caffeine	0-8	adenosine deaminase	Homo sapiens	29-48
7888295-4	1994	The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin.	Caffeine	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74
7888295-6	1994	The caffeine breath test can be used to study drug interactions involving CYP1A2 in children.	Caffeine	4-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	74-80
7954461-10	1994	At the end of each period, subjects were tested for CYP1A2 and NAT2 enzyme activity by caffeine metabolism phenotyping.	Caffeine	87-95	N-acetyltransferase 2	Homo sapiens	63-67
7723472-1	1994	Adenosine deaminase (ADA) activity was increased in spleen and thymus of rat with single and multiple caffeine treatments (10 and 20 mg/kg/day).	Caffeine	102-110	adenosine deaminase	Rattus norvegicus	0-19
7723472-1	1994	Adenosine deaminase (ADA) activity was increased in spleen and thymus of rat with single and multiple caffeine treatments (10 and 20 mg/kg/day).	Caffeine	102-110	adenosine deaminase	Rattus norvegicus	21-24
7723472-4	1994	This study indicates that caffeine may potentiate immunity with the modulation of adenosinergic system through increasing splenic and thymic ADA activity.	Caffeine	26-34	adenosine deaminase	Homo sapiens	141-144
7972693-0	1994	Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine.	Caffeine	136-144	cyclin B1	Homo sapiens	24-33
7892112-6	1994	The alpha 2A-adrenoceptor-activated calcium influx was unchanged after complete release of the stored calcium induced by applications of ryanodine and caffeine.	Caffeine	151-159	adrenoceptor alpha 2A	Rattus norvegicus	4-25
7972693-7	1994	Caffeine treatment of irradiated HeLa cells also resulted in an elevation in the levels of cyclin B1 message.	Caffeine	0-8	cyclin B1	Homo sapiens	91-100
7972693-9	1994	The findings that both staurosporine and caffeine treatments reverse the depression in cyclin B1 expression suggest that these two compounds may act on a common pathway of cell cycle control in response to radiation injury.	Caffeine	41-49	cyclin B1	Homo sapiens	87-96
7980529-5	1994	Both caffeine-induced Ca2+ elevations and the inhibitory effect of ryanodine on spontaneous activity were also dependent on the continued presence of TGF-beta 1; in its absence these indices of SR function were severely compromised.	Caffeine	5-13	transforming growth factor, beta 1	Rattus norvegicus	150-160
7986202-3	1994	In addition, the effects of methylxanthines (e.g. theophylline and caffeine) were studied on PAF-induced platelet aggregation in PRP isolated from blood samples from healthy subjects.	Caffeine	67-75	PCNA clamp associated factor	Homo sapiens	93-96
7893591-0	1994	Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	36-42
7893591-4	1994	N1- and N7-demethylation indices of caffeine also reflect CYP1A2 activity and were also correlated with clozapine clearance (rs = 0.89 and 0.85; P = 0.0013 and 0.0023; respectively).	Caffeine	36-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-64
7955822-3	1994	In two studies, comprising 911 patients, the caffeine-containing analgesic consisted of a combination of 1000 mg acetaminophen and 130 mg caffeine (APAP/CAF).	Caffeine	45-53	lysine acetyltransferase 2B	Homo sapiens	153-156
7927253-5	1994	Cytochrome P-450 1A2 activity was monitored by means of the 13C-[N3-methyl]caffeine breath test and by means of plasma caffeine clearance before omeprazole treatment with 120 mg/day, on the seventh day of dosage and after a 7-day washout.	Caffeine	75-83	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-20
7862940-1	1994	Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice.	Caffeine	44-52	chromatin assembly factor 1, subunit B (p60)	Mus musculus	54-74
7842510-3	1994	[3H]CHA binding was greatest in CA1 and CA3 hippocampus in both caffeine-exposed and control rats across all ages.	Caffeine	64-72	carbonic anhydrase 1	Homo sapiens	32-35
7842510-3	1994	[3H]CHA binding was greatest in CA1 and CA3 hippocampus in both caffeine-exposed and control rats across all ages.	Caffeine	64-72	carbonic anhydrase 3	Homo sapiens	40-43
7833826-2	1994	We have investigated the inhibition of caffeine 3-demethylation by metabolites of ANF as well as ANF by human liver microsomes.	Caffeine	39-47	natriuretic peptide A	Homo sapiens	82-85
7834196-10	1994	In the presence of caffeine (5 mM) or ryanodine (100 microM) in the pipette solution, which deplete the intracellular Ca2+ store, the ATP-induced Cai rise was greatly reduced.	Caffeine	19-27	carbonic anhydrase 2	Rattus norvegicus	118-121
7853225-2	1994	We investigated the effects of acidosis, inorganic phosphate (Pi) and caffeine on the Ca2+ affinity of isolated fast-twitch skeletal and cardiac troponin C (TnC), labelled with fluorescent probes to report Ca2+ binding to the regulatory sites.	Caffeine	70-78	tenascin C	Homo sapiens	145-155
7853225-2	1994	We investigated the effects of acidosis, inorganic phosphate (Pi) and caffeine on the Ca2+ affinity of isolated fast-twitch skeletal and cardiac troponin C (TnC), labelled with fluorescent probes to report Ca2+ binding to the regulatory sites.	Caffeine	70-78	tenascin C	Homo sapiens	157-160
7700690-2	1994	The caffeine-induced elevated intracellular cAMP resulted in normalization of myocardial contractility in reperfusion, as well as in stabilization of norepinephrine levels and cardiac adrenoreactivity during ischemia and reperfusion.	Caffeine	4-12	cathelicidin antimicrobial peptide	Rattus norvegicus	44-48
8069859-4	1994	Brief caffeine exposures (5 or 10 mM for 1-2 h) caused specific tyrosine dephosphorylation and activation of p34cdc2 kinase, and mitotic progression to a limited extent, in cells which were arrested in G2 following etoposide treatment.	Caffeine	6-14	cyclin dependent kinase 1	Homo sapiens	109-116
7523185-2	1994	Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel.	Caffeine	89-97	ryanodine receptor 1	Homo sapiens	38-41
7519848-0	1994	Caffeine inhibits cytosolic calcium oscillations induced by noradrenaline and vasopressin in rat hepatocytes.	Caffeine	0-8	arginine vasopressin	Rattus norvegicus	78-89
7830331-6	1994	The Ca2+ waves were abolished by the removal of extracellular Ca2+, or by the perfusion with ryanodine (10 microM) or caffeine (20 mM).	Caffeine	118-126	carbonic anhydrase 2	Rattus norvegicus	4-7
7519848-2	1994	In single cells, caffeine (5-10 mM) inhibited [Ca2+]i oscillations induced both by noradrenaline (0.1 microM) and by vasopressin (0.1 nM).	Caffeine	17-25	arginine vasopressin	Rattus norvegicus	117-128
7519848-3	1994	Caffeine shifted the dose-response curves of the [Ca2+]i rise induced by vasopressin (0.5 to 2 nM) and noradrenaline (from 80 to 580 nM) in suspensions of liver cells loaded with quin2.	Caffeine	0-8	arginine vasopressin	Rattus norvegicus	73-84
7987405-15	1994	CYP1A2 activity, as determined by a caffeine metabolic ratio ((AFMU + 1X + 1U)/1, 7U), was multimodally distributed and was clearly increased in smokers.	Caffeine	36-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
8071875-7	1994	In the studies of caffeine effect, the results showed that the effect of caffeine on isolated TnC was similar to that of MCI-154.	Caffeine	73-81	tenascin C	Bos taurus	94-97
7972292-1	1994	The involvement of CRH and the sympatho-adrenal system in the effects of caffeine on food intake and body weight gain has been investigated in rats.	Caffeine	73-81	corticotropin releasing hormone	Rattus norvegicus	19-22
7972292-7	1994	A significant (p &lt; 0.05) interaction effect of caffeine and alpha-helical-CRH(9-41) was found on the cumulative food intake at 1, 6, and 8 h, and on the amount of food eaten between the 4-6-h interval following the injection of caffeine; the effects of caffeine on food intake and body weight gain seem largely prevented by the use of a CRH antagonist.	Caffeine	50-58	corticotropin releasing hormone	Rattus norvegicus	340-343
7972292-7	1994	A significant (p &lt; 0.05) interaction effect of caffeine and alpha-helical-CRH(9-41) was found on the cumulative food intake at 1, 6, and 8 h, and on the amount of food eaten between the 4-6-h interval following the injection of caffeine; the effects of caffeine on food intake and body weight gain seem largely prevented by the use of a CRH antagonist.	Caffeine	231-239	corticotropin releasing hormone	Rattus norvegicus	77-80
7972292-7	1994	A significant (p &lt; 0.05) interaction effect of caffeine and alpha-helical-CRH(9-41) was found on the cumulative food intake at 1, 6, and 8 h, and on the amount of food eaten between the 4-6-h interval following the injection of caffeine; the effects of caffeine on food intake and body weight gain seem largely prevented by the use of a CRH antagonist.	Caffeine	231-239	corticotropin releasing hormone	Rattus norvegicus	77-80
8033500-5	1994	Our results show that, in patients with porphyria and in healthy subjects, exogenous heme is able to accelerate the reactions mediated by the cytochrome isozymes CYP2D6 (debrisoquin) and CYP3A4 (lidocaine) but not reactions mediated by CYP1A2 (caffeine) and CYP2A6 (coumarin).	Caffeine	244-252	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	162-168
7974626-13	1994	A recent panel study suggests that determination of CYP1A2 activity with the caffeine test may be very useful for the dosing of clozapine.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58
7920209-0	1994	Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.	Caffeine	60-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-21
7920209-1	1994	Caffeine has been used as a metabolic probe to determine the relative levels of CYP1A2 activity in different individuals, since this compound is specifically 3-demethylated by CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
7920209-1	1994	Caffeine has been used as a metabolic probe to determine the relative levels of CYP1A2 activity in different individuals, since this compound is specifically 3-demethylated by CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	176-182
8016087-2	1994	We employed digital imaging with fura-2 to study the effects of thapsigargin (which blocks Ca2+ sequestration in the inositol trisphosphate-sensitive store) and caffeine on the cytosolic free Ca2+ concentration ([Ca2+]cyt) in cultured arterial myocytes.	Caffeine	161-169	carbonic anhydrase 2	Homo sapiens	192-195
8016087-2	1994	We employed digital imaging with fura-2 to study the effects of thapsigargin (which blocks Ca2+ sequestration in the inositol trisphosphate-sensitive store) and caffeine on the cytosolic free Ca2+ concentration ([Ca2+]cyt) in cultured arterial myocytes.	Caffeine	161-169	carbonic anhydrase 2	Homo sapiens	192-195
8016087-4	1994	Moreover, Ca2+ could be transferred between the two stores, as prior application of caffeine, which alone evoked little or no rise in [Ca2+]cyt, significantly augmented the response to thapsigargin.	Caffeine	84-92	carbonic anhydrase 2	Homo sapiens	10-13
8016087-4	1994	Moreover, Ca2+ could be transferred between the two stores, as prior application of caffeine, which alone evoked little or no rise in [Ca2+]cyt, significantly augmented the response to thapsigargin.	Caffeine	84-92	carbonic anhydrase 2	Homo sapiens	135-138
8016087-5	1994	Conversely, a substantial caffeine-induced rise in [Ca2+]cyt was observed only after the ability of the thapsigargin-sensitive Ca2+ store to sequester Ca2+ was inhibited.	Caffeine	26-34	carbonic anhydrase 2	Homo sapiens	52-55
8016087-5	1994	Conversely, a substantial caffeine-induced rise in [Ca2+]cyt was observed only after the ability of the thapsigargin-sensitive Ca2+ store to sequester Ca2+ was inhibited.	Caffeine	26-34	carbonic anhydrase 2	Homo sapiens	127-130
8016087-5	1994	Conversely, a substantial caffeine-induced rise in [Ca2+]cyt was observed only after the ability of the thapsigargin-sensitive Ca2+ store to sequester Ca2+ was inhibited.	Caffeine	26-34	carbonic anhydrase 2	Homo sapiens	127-130
8016087-8	1994	The latter studies revealed spatial differences in the location of the thapsigargin-sensitive and caffeine-sensitive Ca2+ stores (measured as thapsigargin-sensitive and caffeine-sensitive chlortetracycline fluorescence).	Caffeine	98-106	carbonic anhydrase 2	Homo sapiens	117-120
8016087-8	1994	The latter studies revealed spatial differences in the location of the thapsigargin-sensitive and caffeine-sensitive Ca2+ stores (measured as thapsigargin-sensitive and caffeine-sensitive chlortetracycline fluorescence).	Caffeine	169-177	carbonic anhydrase 2	Homo sapiens	117-120
7931515-20	1994	1S,3S ACPD was a weak agonist at the APB receptor.	Caffeine	0-5	homer scaffold protein 2	Homo sapiens	6-10
8081318-5	1994	The demethylation of caffeine by the hepatic cytochrome P-450 oxygenases begins within minutes and dimethylxanthines (especially paraxanthine) are generated.	Caffeine	21-29	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-61
7514535-7	1994	Methylxanthines (caffeine and theophylline) as well as several calcium-mobilizing agents inhibited the expression/activity of both iNOS and VCAM-1 in MME.	Caffeine	17-25	nitric oxide synthase 2, inducible	Mus musculus	131-135
7514535-7	1994	Methylxanthines (caffeine and theophylline) as well as several calcium-mobilizing agents inhibited the expression/activity of both iNOS and VCAM-1 in MME.	Caffeine	17-25	vascular cell adhesion molecule 1	Mus musculus	140-146
7920698-0	1994	Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.	Caffeine	36-44	N-acetyltransferase 1	Homo sapiens	119-123
7920690-0	1994	Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.	Caffeine	59-67	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
7920690-1	1994	Several procedures to monitor CYP1A2 activity in vivo by the use of caffeine as a probe have been proposed.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-36
7920690-4	1994	In this study, we retrospectively analysed four clinical trials comprising 78 subjects to validate the use of the paraxanthine/caffeine ratios in plasma and saliva for CYP1A2 activity.	Caffeine	127-135	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	168-174
7920698-3	1994	Fourteen slow acetylators and four fast acetylators (the NAT2 polymorphism) were identified by the caffeine metabolite ratio.	Caffeine	99-107	N-acetyltransferase 2	Homo sapiens	57-61
7920690-10	1994	In conclusion, the paraxanthine/caffeine ratios in plasma and saliva appear a valid and inexpensive method of assessing CYP1A2 activity in vivo.	Caffeine	32-40	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-126
8161510-9	1994	Caffeine also increased A beta production, possibly through release of calcium from intracellular stores.	Caffeine	0-8	amyloid beta precursor protein	Homo sapiens	24-30
7920691-0	1994	Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-30
7754532-5	1994	In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and heparin inhibits the IP3 receptor and activates the ryanodine receptor.	Caffeine	33-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	92-104
7514503-4	1994	By coexpressing the RyR and FKBP12 in insect cells, we have demonstrated that FKBP12 modulates channel gating by increasing channels with full conductance levels (by &gt; 400%), decreasing open probability after caffeine activation (from 0.63 +/- 0.09 to 0.04 +/- 0.02), and increasing mean open time (from 4.4 +/- 0.6 ms to 75 +/- 41 ms).	Caffeine	212-220	ryanodine receptor 1	Homo sapiens	20-23
7514503-4	1994	By coexpressing the RyR and FKBP12 in insect cells, we have demonstrated that FKBP12 modulates channel gating by increasing channels with full conductance levels (by &gt; 400%), decreasing open probability after caffeine activation (from 0.63 +/- 0.09 to 0.04 +/- 0.02), and increasing mean open time (from 4.4 +/- 0.6 ms to 75 +/- 41 ms).	Caffeine	212-220	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	78-84
8162667-12	1994	The three urinary caffeine metabolite ratios sampled at the convenient interval of 5 to 8 hours after administration showed the dependence of CYP1A2 induction by omeprazole on the dose and genetic trait of S-mephenytoin hydroxylase.	Caffeine	18-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
8143395-3	1994	Our in vivo studies suggest that CYP1A2 is involved, at least in part, in the primary N-demethylations of caffeine.	Caffeine	106-114	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39
7520134-0	1994	Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat.	Caffeine	113-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
7520134-17	1994	With caffeine treatment, about 73% of neuron-like cells were c-fos labelled in the lateral striatum, but labelling was much less pronounced in the medial part or in the accumbens.	Caffeine	5-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-66
8056639-5	1994	Caffeine and pentoxifylline increased (P &lt; 0.05) the MOT, VSL, VCL, and ALH of cryopreserved sperm at 0.01-20 mM, in a dose-dependent manner.	Caffeine	0-8	vinculin	Felis catus	66-69
8146020-1	1994	Using indo-1 based microfluorometry for measuring the cytoplasmic free calcium concentration ([Ca2+]i), the properties of caffeine-induced Ca2+ release from internal stores were studied in rat cultured central and peripheral neurones, including dorsal root ganglia (DRG) neurones, neurones from nucleus cuneatus, CA1 and CA3 hippocampal region and pyramidal neocortical neurones.	Caffeine	122-130	carbonic anhydrase 2	Rattus norvegicus	139-142
8005843-4	1994	They ran at a velocity corresponding to their lactate threshold for 60 min in a caffeine withdrawal or caffeinated condition.	Caffeine	80-88	RAN, member RAS oncogene family	Homo sapiens	5-8
8293564-6	1994	The Na(+)-Ca2+ exchanger generated this current (INa-Ca), because it was suppressed by rapid replacement of Na+ with Li+ and depletion of the intracellular Ca2+ pool by caffeine.	Caffeine	169-177	carbonic anhydrase 2	Mesocricetus auratus	10-13
8293564-6	1994	The Na(+)-Ca2+ exchanger generated this current (INa-Ca), because it was suppressed by rapid replacement of Na+ with Li+ and depletion of the intracellular Ca2+ pool by caffeine.	Caffeine	169-177	carbonic anhydrase 2	Mesocricetus auratus	156-159
7906891-0	1994	D1 and D2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats.	Caffeine	46-54	dopamine receptor D2	Rattus norvegicus	7-27
8021804-3	1994	Dopamine D1- and D2-receptor bockade, depletion of stored dopamine, and inhibition of dopamine synthesis could reduce the ambulation increased by single administration of morphine, buprenorphine and caffeine, and by combined administration of morphine and buprenorphine with caffeine.	Caffeine	199-207	dopamine receptor D1	Mus musculus	0-28
8021804-3	1994	Dopamine D1- and D2-receptor bockade, depletion of stored dopamine, and inhibition of dopamine synthesis could reduce the ambulation increased by single administration of morphine, buprenorphine and caffeine, and by combined administration of morphine and buprenorphine with caffeine.	Caffeine	275-283	dopamine receptor D1	Mus musculus	0-28
8014220-1	1994	Caffeine is a popular compound for phenotyping individuals for CYP4501A2, xanthine oxidase (XO) and N-acetyltransferase (NAT) utilising urinary metabolites.	Caffeine	0-8	bromodomain containing 2	Homo sapiens	100-119
8014220-1	1994	Caffeine is a popular compound for phenotyping individuals for CYP4501A2, xanthine oxidase (XO) and N-acetyltransferase (NAT) utilising urinary metabolites.	Caffeine	0-8	bromodomain containing 2	Homo sapiens	121-124
8183432-10	1994	ATP- and caffeine-induced [Ca]i transients were independent, indicating two non-overlapping Ca2+ storage sites.	Caffeine	9-17	carbonic anhydrase 1	Rattus norvegicus	27-31
8183432-11	1994	Only caffeine effects were potentiated at an elevated [Ca]i level, showing a Ca(2+)-induced Ca2+ release.	Caffeine	5-13	carbonic anhydrase 1	Rattus norvegicus	55-59
8146020-0	1994	Different properties of caffeine-sensitive Ca2+ stores in peripheral and central mammalian neurones.	Caffeine	24-32	carbonic anhydrase 2	Homo sapiens	43-46
8146020-1	1994	Using indo-1 based microfluorometry for measuring the cytoplasmic free calcium concentration ([Ca2+]i), the properties of caffeine-induced Ca2+ release from internal stores were studied in rat cultured central and peripheral neurones, including dorsal root ganglia (DRG) neurones, neurones from nucleus cuneatus, CA1 and CA3 hippocampal region and pyramidal neocortical neurones.	Caffeine	122-130	carbonic anhydrase 1	Rattus norvegicus	313-316
8146020-1	1994	Using indo-1 based microfluorometry for measuring the cytoplasmic free calcium concentration ([Ca2+]i), the properties of caffeine-induced Ca2+ release from internal stores were studied in rat cultured central and peripheral neurones, including dorsal root ganglia (DRG) neurones, neurones from nucleus cuneatus, CA1 and CA3 hippocampal region and pyramidal neocortical neurones.	Caffeine	122-130	carbonic anhydrase 3	Rattus norvegicus	321-324
8146020-2	1994	Under resting conditions the Ca2+ content of internal stores in DRG neurones was high enough to produce caffeine-triggered [Ca2+]i transients.	Caffeine	104-112	carbonic anhydrase 2	Homo sapiens	29-32
8146020-2	1994	Under resting conditions the Ca2+ content of internal stores in DRG neurones was high enough to produce caffeine-triggered [Ca2+]i transients.	Caffeine	104-112	carbonic anhydrase 2	Homo sapiens	124-127
8146020-3	1994	Caffeine-induced Ca2+ release depleted internal stores in DRG neurones, but they refilled themselves spontaneously up to 81.4 +/- 5.67% within 10 minutes.	Caffeine	0-8	carbonic anhydrase 2	Homo sapiens	17-20
8128903-0	1993	Caffeine-induced expression of the proto-oncogene c-fos in rat striatum is increased after dopamine denervation.	Caffeine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-55
8242632-0	1993	Mutagenicity induced by hyperthermia, hot mate infusion, and hot caffeine in Saccharomyces cerevisiae.	Caffeine	65-73	alcohol dehydrogenase iron containing 1	Homo sapiens	61-64
8242632-1	1993	Mate, an infusion containing caffeine (3 g/liter), is drunk hot by most Uruguayan, North Argentinian, and South Brazilian people.	Caffeine	29-37	alcohol dehydrogenase iron containing 1	Homo sapiens	60-63
8242632-6	1993	Hot caffeine also produced a time-dependent mutagenic effect, whereas hot mate infusion determined a significantly lower mutagenic effect than hot caffeine.	Caffeine	4-12	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
8242632-6	1993	Hot caffeine also produced a time-dependent mutagenic effect, whereas hot mate infusion determined a significantly lower mutagenic effect than hot caffeine.	Caffeine	147-155	alcohol dehydrogenase iron containing 1	Homo sapiens	143-146
8145166-23	1993	Pretreatment with Li+ significantly enhanced ITRH, suggesting that ITRH is involved in the elevation of intracellular free Ca2+ released from the inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ store site but not from the caffeine-sensitive one.	Caffeine	224-232	carbonic anhydrase 2	Rattus norvegicus	123-126
8297044-3	1993	This hypothesis was investigated using immunohistochemistry to determine whether an acute (3 h) dose of 30 mg/kg caffeine alters the distribution of hsp 90, 70 and 25 in 10.5-12.5 g.d. rat embryos.	Caffeine	113-121	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	149-155
8145155-9	1993	A low concentration of caffeine (0.05 mM), applied to cells showing a small depolarization-induced [Ca2+]i transient which reached a peak at the end of the voltage step, produced an increase in amplitude and in duration of the [Ca2+]i rise without changing the amplitude of the depolarization-induced Ca2+ current.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	100-103
8145155-9	1993	A low concentration of caffeine (0.05 mM), applied to cells showing a small depolarization-induced [Ca2+]i transient which reached a peak at the end of the voltage step, produced an increase in amplitude and in duration of the [Ca2+]i rise without changing the amplitude of the depolarization-induced Ca2+ current.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	228-231
8145166-23	1993	Pretreatment with Li+ significantly enhanced ITRH, suggesting that ITRH is involved in the elevation of intracellular free Ca2+ released from the inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ store site but not from the caffeine-sensitive one.	Caffeine	224-232	carbonic anhydrase 2	Rattus norvegicus	191-194
8145155-9	1993	A low concentration of caffeine (0.05 mM), applied to cells showing a small depolarization-induced [Ca2+]i transient which reached a peak at the end of the voltage step, produced an increase in amplitude and in duration of the [Ca2+]i rise without changing the amplitude of the depolarization-induced Ca2+ current.	Caffeine	23-31	carbonic anhydrase 2	Rattus norvegicus	228-231
8145155-11	1993	The depolarization-induced [Ca2+]i rise was shortened and reduced in amplitude after noradrenaline- (NA 10 microM) or caffeine- (5 mM) induced release of Ca2+ store and when the patch pipette solution contained ryanodine (100 microM).	Caffeine	118-126	carbonic anhydrase 2	Rattus norvegicus	28-31
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
8145155-11	1993	The depolarization-induced [Ca2+]i rise was shortened and reduced in amplitude after noradrenaline- (NA 10 microM) or caffeine- (5 mM) induced release of Ca2+ store and when the patch pipette solution contained ryanodine (100 microM).	Caffeine	118-126	carbonic anhydrase 2	Rattus norvegicus	154-157
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
8357954-5	1993	However, caffeine (20 mM) and ryanodine (20 microM) greatly attenuated the [Ca2+] increase induced by AVP in both regions (61 +/- 21 and 42 +/- 15%, respectively).	Caffeine	9-17	arginine vasopressin	Rattus norvegicus	102-105
8295075-9	1993	The currents in dnc and rut fibers showed strikingly altered responses to caffeine and W7.	Caffeine	74-82	dunce	Drosophila melanogaster	16-19
8244516-0	1993	Caffeine attenuates the renal vascular response to angiotensin II infusion.	Caffeine	0-8	angiotensinogen	Homo sapiens	51-65
8244516-10	1993	Caffeine did not alter either baseline blood pressure or the blood pressure response to Ang II but did increase baseline plasma renin activity from 0.72 +/- 0.09 to 1.42 +/- 0.26 ng angiotensin I/mL per hour (P = .01).	Caffeine	0-8	renin	Homo sapiens	128-133
8244516-10	1993	Caffeine did not alter either baseline blood pressure or the blood pressure response to Ang II but did increase baseline plasma renin activity from 0.72 +/- 0.09 to 1.42 +/- 0.26 ng angiotensin I/mL per hour (P = .01).	Caffeine	0-8	angiotensinogen	Homo sapiens	182-195
8402636-1	1993	Caffeine (3,7-dihydro-1,3,7,-trimethyl-1H-purine-6,6-dione; CAF) is known to potentiate the cytotoxic effects of DNA damaging agents such as ionizing radiation and alkylating agents.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	60-63
8160296-0	1993	Similarity of the effects of tosyl-L-arginine methyl ester, atropine, caffeine and antitumour alkylating agent on some biological functions of thrombin and platelet 12-lipoxygenase.	Caffeine	70-78	coagulation factor II, thrombin	Homo sapiens	143-151
8357954-6	1993	On the ratio image, the nuclear region was discriminated from other regions at the peak response to AVP in preparations treated with caffeine and ryanodine, whereas the outline of the nuclear region was indistinct in untreated preparations.	Caffeine	133-141	arginine vasopressin	Rattus norvegicus	100-103
8101161-4	1993	When [Ca2+]i was raised by perfusion with caffeine or under N2, activation of the protein kinase C pathway (PKC) produced a small but significant release of CK.	Caffeine	42-50	protein kinase C, gamma	Rattus norvegicus	108-111
8512808-3	1993	The rates of cell death increased significantly when cells cultured with TNF for 24 h were exposed to caffeine (2.5-20 mM).	Caffeine	102-110	tumor necrosis factor	Mus musculus	73-76
8512808-4	1993	The magnitude of the enhancement by caffeine was TNF and caffeine dose-dependent.	Caffeine	36-44	tumor necrosis factor	Mus musculus	49-52
8512808-7	1993	Caffeine had great enhancer effect on L929 cells exposed to TNF for 24 h, but the effect was reduced in cells with either less than 24 h or greater than 28 h of exposure.	Caffeine	0-8	tumor necrosis factor	Mus musculus	60-63
8512808-9	1993	Exposure of TNF-treated cells to caffeine caused a greater increase in the proportion of apoptotic cells as well as the extent of internucleosomal DNA fragmentation.	Caffeine	33-41	tumor necrosis factor	Mus musculus	12-15
8358532-0	1993	Mg2+ and caffeine-induced intracellular Ca2+ release in human vascular endothelial cells.	Caffeine	9-17	carbonic anhydrase 2	Homo sapiens	40-43
8358532-1	1993	Interaction of ionized magnesium ([Mg2+]o) and caffeine in regulation of intracellular free calcium concentration ([Ca2+]i) in human aortic endothelial cells was studied using fura-2 and digital imaging microscopy.	Caffeine	47-55	carbonic anhydrase 2	Homo sapiens	116-119
8358532-4	1993	However, a combined superfusion of the cells with 0.3 mM [Mg2+]o and 10 mM caffeine resulted in a significant elevation of [Ca2+]i to 382.8 +/- 57.1 nM, probably by release of Ca2+ from internal stores, which was attenuated by NiCl2 (1 mM).	Caffeine	75-83	carbonic anhydrase 2	Homo sapiens	124-127
8358532-4	1993	However, a combined superfusion of the cells with 0.3 mM [Mg2+]o and 10 mM caffeine resulted in a significant elevation of [Ca2+]i to 382.8 +/- 57.1 nM, probably by release of Ca2+ from internal stores, which was attenuated by NiCl2 (1 mM).	Caffeine	75-83	carbonic anhydrase 2	Homo sapiens	176-179
8101161-7	1993	The PKC inhibitor, 1-(5-isoquinolinyl sulphonyl)-2-methyl piperazine, (2 x 10(-6) M) inhibited both the Ca(2+)-paradox and caffeine-induced release of <protein-id="315323">CK.	Caffeine	123-131	protein kinase C, gamma	Rattus norvegicus	4-7
8488088-5	1993	Rapid application of caffeine produced a transient increase of [Ca2+]i which was accompanied by a transient inward Na-Ca exchange current.	Caffeine	21-29	nascent polypeptide associated complex subunit alpha	Rattus norvegicus	115-120
8332255-0	1993	Caffeine regulates neurotensin and cholecystokinin messenger RNA expression in the rat striatum.	Caffeine	0-8	neurotensin	Rattus norvegicus	19-30
8332255-0	1993	Caffeine regulates neurotensin and cholecystokinin messenger RNA expression in the rat striatum.	Caffeine	0-8	cholecystokinin	Rattus norvegicus	35-50
8332255-5	1993	In the present study, in situ hybridization histochemistry was used to investigate the putative regulation of neurotensin and cholecystokinin messenger RNA expression by caffeine in the rat striatum.	Caffeine	170-178	neurotensin	Rattus norvegicus	110-121
8332255-5	1993	In the present study, in situ hybridization histochemistry was used to investigate the putative regulation of neurotensin and cholecystokinin messenger RNA expression by caffeine in the rat striatum.	Caffeine	170-178	cholecystokinin	Rattus norvegicus	126-141
8332255-7	1993	Chronic caffeine administration induced a dramatic increase in neurotensin messenger RNA in the subcallosal region of the caudate-putamen and a moderate increase in the shell sector of the accumbens nucleus.	Caffeine	8-16	neurotensin	Rattus norvegicus	63-74
8332255-8	1993	Similarly, caffeine induced a significant striatal expression of cholecystokinin messenger RNA in the dorsolateral and ventrolateral quadrants but was not restricted to the subcallosal area.	Caffeine	11-19	cholecystokinin	Rattus norvegicus	65-80
8332255-11	1993	We therefore concluded that in the intact striatum normally innervated by dopaminergic fibers, caffeine, probably acting through a presynaptic A2 receptor, induced a relative dopamine depletion which in turn led to the induction of neurotensin and cholecystokinin expression in subsets of striatal neurons.	Caffeine	95-103	neurotensin	Rattus norvegicus	232-243
8332255-11	1993	We therefore concluded that in the intact striatum normally innervated by dopaminergic fibers, caffeine, probably acting through a presynaptic A2 receptor, induced a relative dopamine depletion which in turn led to the induction of neurotensin and cholecystokinin expression in subsets of striatal neurons.	Caffeine	95-103	cholecystokinin	Rattus norvegicus	248-263
8485024-0	1993	Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.	Caffeine	110-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
8485024-2	1993	The effects of grapefruit juice and naringenin on the activity of the human cytochrome P450 isoform CYP1A2 were evaluated using caffeine as a probe substrate.	Caffeine	128-136	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
8474022-6	1993	Other putative human CYP1A xenobiotic substrates and inhibitors, including caffeine, 5- and 8-methoxypsoralen, nifedipine, paraxanthine, propranolol and theophylline similarly inhibited CYP1A1- and 1A2-catalyzed phenacetin O-deethylation and the high-affinity human liver phenacetin O-deethylase.	Caffeine	75-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-192
8345495-0	1993	Blood pressure, plasma catecholamine and renin responses to caffeine in elderly hypertensives.	Caffeine	60-68	renin	Homo sapiens	41-46
8345495-3	1993	After 48 hours caffeine abstention supine SBP was higher over the 120 minute study period following acute caffeine loading than following placebo (10 mmHg; 95% Cl 3-17 mmHg, P = 0.016) although the overall post-caffeine rise from baseline values was small (2 mmHg; -3 to 8 mmHg, P = 0.30).	Caffeine	15-23	selenium binding protein 1	Homo sapiens	42-45
8345495-3	1993	After 48 hours caffeine abstention supine SBP was higher over the 120 minute study period following acute caffeine loading than following placebo (10 mmHg; 95% Cl 3-17 mmHg, P = 0.016) although the overall post-caffeine rise from baseline values was small (2 mmHg; -3 to 8 mmHg, P = 0.30).	Caffeine	106-114	selenium binding protein 1	Homo sapiens	42-45
8345495-3	1993	After 48 hours caffeine abstention supine SBP was higher over the 120 minute study period following acute caffeine loading than following placebo (10 mmHg; 95% Cl 3-17 mmHg, P = 0.016) although the overall post-caffeine rise from baseline values was small (2 mmHg; -3 to 8 mmHg, P = 0.30).	Caffeine	106-114	selenium binding protein 1	Homo sapiens	42-45
8492147-13	1993	Pretreatment with Li+ significantly enhanced the I5-HT, indicating that I5-HT is involved in the elevation of intracellular free Ca2+ released from inositol triphosphate (IP3)-sensitive Ca2+ store sites but not from the caffeine-sensitive ones.	Caffeine	220-228	carbonic anhydrase 2	Rattus norvegicus	129-132
8488088-7	1993	Ni2+ (5 mM) inhibited the current and decreased the rate of fall of [Ca2+]i to 32% of the control suggesting that Na-Ca exchange is responsible for 68% of Ca removal from the cytoplasm following the addition of caffeine.	Caffeine	211-219	nascent polypeptide associated complex subunit alpha	Rattus norvegicus	114-119
8388869-2	1993	On two cell lines, PTX or caffeine treatment enhanced H-2K and H-2D expression.	Caffeine	26-34	histocompatibility 2, K1, K region	Mus musculus	54-58
8382634-5	1993	Haploid cells carrying the double mutation ppz1 ppz2 were unable to grow in the presence of 5 mM caffeine.	Caffeine	97-105	salt homeostasis regulator	Saccharomyces cerevisiae S288C	43-47
8449979-8	1993	Caffeine treatment at 20 degrees C resulted in a selective and reversible translocation of the pre- and cis-Golgi marker protein (p58) to the periphery of the cell.	Caffeine	0-8	cyclin dependent kinase 11B	Homo sapiens	130-133
8449979-9	1993	This caffeine-induced effect on the Golgi complex was different from that induced by BFA, since mannosidase II, a Golgi stack marker, remained perinuclearly located and the Golgi stack coat protein, beta-COP, was not detached from Golgi membranes in the presence of 10 mM caffeine at 20 degrees C. Electron microscopic analysis showed that, in the presence of caffeine at 20 degrees C, the morphology of the Golgi stack was altered and accumulation of numerous small vesicles in the Golgi region was observed.	Caffeine	5-13	COPI coat complex subunit beta 2	Homo sapiens	199-207
8457852-1	1993	The effect of caffeine on the CA1 pyramidal neurons freshly dissociated from rat hippocampus was investigated with nystatin-perforated patch technique under voltage-clamp condition.	Caffeine	14-22	carbonic anhydrase 1	Rattus norvegicus	30-33
8457852-9	1993	In the absence of the extracellular Ca2+, an application of 10 mM caffeine depleted the caffeine-sensitive Ca2+ pools.	Caffeine	66-74	carbonic anhydrase 2	Rattus norvegicus	107-110
8457852-9	1993	In the absence of the extracellular Ca2+, an application of 10 mM caffeine depleted the caffeine-sensitive Ca2+ pools.	Caffeine	88-96	carbonic anhydrase 2	Rattus norvegicus	107-110
8457852-11	1993	It was concluded that rat hippocampal pyramidal neurons have a caffeine-sensitive Ca2+ pool.	Caffeine	63-71	carbonic anhydrase 2	Rattus norvegicus	82-85
8429824-7	1993	Molecular modeling studies with inhibitors and caffeine showed that it is possible to explain the potency of the quinolones to inhibit CYP1A2 on a molecular level.	Caffeine	47-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-141
8429824-8	1993	The keto group, the carboxylate group, and the core nitrogen at position 1 are likely to be the most important groups for binding to the active site of CYP1A2, because the molecular electrostatic potential of all inhibitors is very similar to that of caffeine in these regions.	Caffeine	251-259	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	152-158
1284565-8	1992	After wash-out of caffeine, the subsequent depolarization induced a [Ca2+]i transient with reduced peak, the degree of suppression depending on the interval between wash-out of caffeine and depolarization.	Caffeine	18-26	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	69-72
8428211-16	1993	After treatment with caffeine to reduce intracellular stored Ca2+, sarafotoxin could still elicit increases in [Ca2+]i and in tension, showing that the caffeine-sensitive intracellular Ca2+ store partially overlaps with the sarafotoxin-sensitive store.	Caffeine	21-29	carbonic anhydrase 2	Rattus norvegicus	61-64
8428211-16	1993	After treatment with caffeine to reduce intracellular stored Ca2+, sarafotoxin could still elicit increases in [Ca2+]i and in tension, showing that the caffeine-sensitive intracellular Ca2+ store partially overlaps with the sarafotoxin-sensitive store.	Caffeine	152-160	carbonic anhydrase 2	Rattus norvegicus	61-64
8428211-16	1993	After treatment with caffeine to reduce intracellular stored Ca2+, sarafotoxin could still elicit increases in [Ca2+]i and in tension, showing that the caffeine-sensitive intracellular Ca2+ store partially overlaps with the sarafotoxin-sensitive store.	Caffeine	152-160	carbonic anhydrase 2	Rattus norvegicus	112-115
8428211-16	1993	After treatment with caffeine to reduce intracellular stored Ca2+, sarafotoxin could still elicit increases in [Ca2+]i and in tension, showing that the caffeine-sensitive intracellular Ca2+ store partially overlaps with the sarafotoxin-sensitive store.	Caffeine	152-160	carbonic anhydrase 2	Rattus norvegicus	112-115
8167959-2	1993	Pregnant CD 1 mice were given single dose of [14C]-caffeine intraperitoneally (i.p.)	Caffeine	51-59	CD1 antigen complex	Mus musculus	9-13
8302420-5	1993	Caffeine exacerbated the development of 2K1C hypertension in association with a higher plasma renin concentration (PRC).	Caffeine	0-8	renin	Rattus norvegicus	94-99
8302420-9	1993	These results suggest that caffeine specifically exacerbates 2K1C hypertension through increasing renin release whereas it ameliorates DOCA-salt hypertension possibly through increasing renal excretion.	Caffeine	27-35	renin	Rattus norvegicus	98-103
8234540-8	1993	Our data showed that the inhibitory effect of Ado on renin activity and blood pressure in salt restricted rats was attenuated by caffeine at the first week but not at six weeks after institution of the low sodium diet.	Caffeine	129-137	renin	Rattus norvegicus	53-58
1336398-6	1992	Indeed, administration of 20 mM caffeine rapidly restored the cAMP level of NGF-deprived neurons to normal (0.34 pmol/well) within 10 min; the level reached a plateau level (0.69 pmol/well) at 10 h. Even after 1 day, the sustained level was maintained in the presence of caffeine.	Caffeine	32-40	nerve growth factor	Homo sapiens	76-79
1336398-6	1992	Indeed, administration of 20 mM caffeine rapidly restored the cAMP level of NGF-deprived neurons to normal (0.34 pmol/well) within 10 min; the level reached a plateau level (0.69 pmol/well) at 10 h. Even after 1 day, the sustained level was maintained in the presence of caffeine.	Caffeine	271-279	nerve growth factor	Homo sapiens	76-79
8446679-5	1993	The number of head twitches produced by caffeine in 5,7-DHT-treated mice was increased twofold by p-chlorophenylalanine (p-CPA), the tryptophan hydroxylase inhibitor.	Caffeine	40-48	carboxypeptidase A1, pancreatic	Mus musculus	123-126
8446679-6	1993	In mice treated with both 5,7-DHT and p-CPA, theophylline induced the responses, although much less potently than caffeine.	Caffeine	114-122	carboxypeptidase A1, pancreatic	Mus musculus	40-43
7748323-1	1993	The expression of c-fos mRNA in rat brain was induced by intraperitoneal (ip) administration of N-methyl-D-aspartate (NMDA) and kainic acid, agonists of different classes of glutamate receptors and by caffeine, an antagonist of adenosine receptors.	Caffeine	201-209	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
8095225-0	1993	Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
8095225-0	1993	Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	69-75
8095225-6	1993	Caffeine was shown to be metabolized by CYP1A2 and CYP1A1.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46
8095225-6	1993	Caffeine was shown to be metabolized by CYP1A2 and CYP1A1.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57
8095225-9	1993	Inhibition studies with caffeine, phenacetin, 17 beta-estradiol, and progesterone as inhibitors of the CYP1A1 and CYP1A2 catalyzed O-deethylation of 7-ethoxyresorufin suggest all compounds as possible substrates of CYP1A enzymes.	Caffeine	24-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	103-109
8095225-9	1993	Inhibition studies with caffeine, phenacetin, 17 beta-estradiol, and progesterone as inhibitors of the CYP1A1 and CYP1A2 catalyzed O-deethylation of 7-ethoxyresorufin suggest all compounds as possible substrates of CYP1A enzymes.	Caffeine	24-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	114-120
8095225-12	1993	These data clearly demonstrate the capacity of human CYP1A1 and CYP1A2 to metabolize caffeine.	Caffeine	85-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
8095225-12	1993	These data clearly demonstrate the capacity of human CYP1A1 and CYP1A2 to metabolize caffeine.	Caffeine	85-93	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	64-70
24234742-11	1993	Caffeine was detected at 25 pmol (5 ng), with a signal-to-noise ratio of 50, 20-muL loop, full scan.	Caffeine	0-8	tripartite motif containing 37	Homo sapiens	80-83
8445983-0	1993	Effect of caffeine treatment on plasma renin activity and angiotensin I concentrations in rats on a low sodium diet.	Caffeine	10-18	renin	Rattus norvegicus	39-44
8445983-4	1993	An earlier study partially addressed this question by showing that chronic blockade of adenosine receptors with caffeine exacerbated both the rise of plasma renin activity and the decline of renal function in 2-kidney-1-clip (2K1C) renovascular hypertensive rats.	Caffeine	112-120	renin	Rattus norvegicus	157-162
8445983-6	1993	The purpose of this study was to reexamine the effect of chronic caffeine consumption on plasma renin activity and angiotensin I levels in animals in another high-renin model, i.e., the low sodium diet.	Caffeine	65-73	renin	Rattus norvegicus	96-101
1492572-0	1992	Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.	Caffeine	71-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
1284565-8	1992	After wash-out of caffeine, the subsequent depolarization induced a [Ca2+]i transient with reduced peak, the degree of suppression depending on the interval between wash-out of caffeine and depolarization.	Caffeine	177-185	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	69-72
1284565-9	1992	The phasic component of the depolarization and the caffeine-induced [Ca2+]i transients were not additive but saturative.	Caffeine	51-59	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	69-72
1284565-18	1992	It is concluded that depolarization-induced influx of Ca2+ through L-type Ca2+ channels induces the release of Ca2+ from intracellular caffeine-sensitive stores which constitutes the major part of the phasic component.	Caffeine	135-143	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	54-57
1284565-18	1992	It is concluded that depolarization-induced influx of Ca2+ through L-type Ca2+ channels induces the release of Ca2+ from intracellular caffeine-sensitive stores which constitutes the major part of the phasic component.	Caffeine	135-143	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	74-77
1284565-18	1992	It is concluded that depolarization-induced influx of Ca2+ through L-type Ca2+ channels induces the release of Ca2+ from intracellular caffeine-sensitive stores which constitutes the major part of the phasic component.	Caffeine	135-143	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	74-77
1429675-8	1992	Finally, subcellular Ca2+ signaling patterns induced by vasopressin were inhibited by caffeine, while neither vasopressin nor microinjection of inositol trisphosphate blocked caffeine-induced increases in cytosolic Ca2+.	Caffeine	86-94	arginine vasopressin S homeolog	Xenopus laevis	56-67
1478854-4	1992	Both PTX and caffeine significantly inhibited mitogen- and SEB-induced proliferation by murine spleen cells, SEB- and antigen-induced proliferation and lymphokine secretion by murine Th1 and Th2 clones, and the generation of antigen-specific antibody producing murine spleen cells.	Caffeine	13-21	negative elongation factor complex member C/D, Th1l	Mus musculus	183-186
1478854-4	1992	Both PTX and caffeine significantly inhibited mitogen- and SEB-induced proliferation by murine spleen cells, SEB- and antigen-induced proliferation and lymphokine secretion by murine Th1 and Th2 clones, and the generation of antigen-specific antibody producing murine spleen cells.	Caffeine	13-21	heart and neural crest derivatives expressed 2	Mus musculus	191-194
1291681-5	1992	The application of BK (10 nM) during cell stimulation by caffeine (1-20 mM) invariably led to a drastic channel activation which was maintained during a recording period longer than that observed in caffeine-free conditions.	Caffeine	57-65	kininogen 1	Bos taurus	19-21
1291681-5	1992	The application of BK (10 nM) during cell stimulation by caffeine (1-20 mM) invariably led to a drastic channel activation which was maintained during a recording period longer than that observed in caffeine-free conditions.	Caffeine	199-207	kininogen 1	Bos taurus	19-21
1291681-6	1992	In addition, the cell exposure to caffeine (20 mM) during the BK stimulation enhanced systematically the channel activation process.	Caffeine	34-42	kininogen 1	Bos taurus	62-64
1291682-9	1992	Because the channel response to caffeine was found to be poorly sensitive to procaine, in contrast to that evoked by BK and TSG, it may be concluded that both BK and TSG activate the same Ca2+ entry pathway.	Caffeine	32-40	kininogen 1	Bos taurus	159-161
1324075-2	1992	Voltage-activated Ca2+ currents and caffeine (1 to 10 mM) were used to increase intracellular Ca2+ in rat cultured dorsal root ganglia (DRG) neurones.	Caffeine	36-44	carbonic anhydrase 2	Rattus norvegicus	94-97
1338095-6	1992	In normal physiological salt solution (PSS), caffeine induced a transient tension development, while it induced a biphasic change in [Ca2+]i.	Caffeine	45-53	carbonic anhydrase 2	Rattus norvegicus	134-137
1338095-13	1992	Caffeine inhibited the increase in [Ca2+]i and tension development during 118 mM-K+ depolarization, in a concentration-dependent manner.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	36-39
1338095-17	1992	Caffeine inhibited the increased [Ca2+]i and developed tension during stimulation by 10(-5) M-noradrenaline, in a concentration-dependent manner.	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	34-37
1338095-24	1992	The characteristic features of the effects of caffeine on vascular smooth muscle, i.e. the transient nature of contraction and the relaxation of precontracted strips could be explained as follows: caffeine is able to reduce [Ca2+]i after releasing Ca2+ from intracellular stores; however, this may play a minor role.	Caffeine	46-54	carbonic anhydrase 2	Rattus norvegicus	225-228
1338095-24	1992	The characteristic features of the effects of caffeine on vascular smooth muscle, i.e. the transient nature of contraction and the relaxation of precontracted strips could be explained as follows: caffeine is able to reduce [Ca2+]i after releasing Ca2+ from intracellular stores; however, this may play a minor role.	Caffeine	46-54	carbonic anhydrase 2	Rattus norvegicus	248-251
1338095-24	1992	The characteristic features of the effects of caffeine on vascular smooth muscle, i.e. the transient nature of contraction and the relaxation of precontracted strips could be explained as follows: caffeine is able to reduce [Ca2+]i after releasing Ca2+ from intracellular stores; however, this may play a minor role.	Caffeine	197-205	carbonic anhydrase 2	Rattus norvegicus	225-228
1338095-24	1992	The characteristic features of the effects of caffeine on vascular smooth muscle, i.e. the transient nature of contraction and the relaxation of precontracted strips could be explained as follows: caffeine is able to reduce [Ca2+]i after releasing Ca2+ from intracellular stores; however, this may play a minor role.	Caffeine	197-205	carbonic anhydrase 2	Rattus norvegicus	248-251
1394840-1	1992	Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-58
1394840-1	1992	Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66
1394840-1	1992	Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO).	Caffeine	0-8	bromodomain containing 2	Homo sapiens	69-88
1510729-1	1992	A study of the fluorescence quenching of human serum albumin (HSA) by caffeine, theophylline and theobromine, based on temperature dependence, has shown that it is predominantly static.	Caffeine	70-78	albumin	Homo sapiens	47-60
1328519-1	1992	The expression of c-fos mRNA in rat brain was induced by intraperitoneal administration of pentylenetetrazole (PTZ) and picrotoxin, which act on the picrotoxin binding site of the gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor complex, by N-methyl-D-aspartate (NMDA) and kainic acid, agonists of different classes of glutamate receptors and by caffeine, an antagonist of adenosine receptors.	Caffeine	355-363	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
1425965-0	1992	Effects of chronic treatment with caffeine on kidney responses to angiotensin II.	Caffeine	34-42	angiotensinogen	Rattus norvegicus	66-80
1425965-2	1992	A partial explanation for these findings could be that chronic administration of caffeine alters the effects of angiotensin II on the kidney.	Caffeine	81-89	angiotensinogen	Rattus norvegicus	112-126
1425965-8	1992	The fact that caffeine potentiates angiotensin II-induced increases in filtration fraction without affecting angiotensin II-induced reductions in renal blood flow is consistent with, but does not prove, the hypothesis that chronic administration of caffeine modifies the effects of angiotensin II on the renal microvasculature.	Caffeine	14-22	angiotensinogen	Rattus norvegicus	35-49
1425965-8	1992	The fact that caffeine potentiates angiotensin II-induced increases in filtration fraction without affecting angiotensin II-induced reductions in renal blood flow is consistent with, but does not prove, the hypothesis that chronic administration of caffeine modifies the effects of angiotensin II on the renal microvasculature.	Caffeine	249-257	angiotensinogen	Rattus norvegicus	35-49
1425965-9	1992	If this inference is correct, caffeine could facilitate renal damage in high-renin hypertension by exacerbating angiotensin II-induced increases in glomerular capillary hydrostatic pressure.	Caffeine	30-38	angiotensinogen	Rattus norvegicus	112-126
1394840-1	1992	Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO).	Caffeine	0-8	bromodomain containing 2	Homo sapiens	90-93
1394840-6	1992	In 103 non-smoking men and 90 non-smoking women the ratio of caffeine metabolites expressing CYP1A2 activity was 4.7 +/- 1.6 and 4.3 +/- 1.9 as compared to 7.8 +/- 2.5 and 7.3 +/- 3.0 in 31 male and 25 female subjects smoking 10 cigarettes/day or more respectively, verifying induction of CYP1A2 by tobacco (P less than 0.05), but minimal sex-related differences.	Caffeine	61-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99
1394840-11	1992	The ratios of metabolites from dietary caffeine in spot urine samples offer ethical, non-invasive and reliable estimates of CYP1A2, NAT and XO.	Caffeine	39-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	124-130
1394840-11	1992	The ratios of metabolites from dietary caffeine in spot urine samples offer ethical, non-invasive and reliable estimates of CYP1A2, NAT and XO.	Caffeine	39-47	bromodomain containing 2	Homo sapiens	132-135
1324075-10	1992	Release of Ca2+ from intracellular stores by caffeine gave rise to sustained inward currents in cells loaded with Cs acetate.	Caffeine	45-53	carbonic anhydrase 2	Rattus norvegicus	11-14
1302044-5	1992	The most striking finding was that CYP2E1 (the ethanol-inducible form) had major influences upon caffeine metabolism: in particular, it catalysed the formation of theophylline and theobromine from caffeine.	Caffeine	97-105	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	35-41
1506431-5	1992	Immunofluorescence localization, endoglycosidase-H analysis, and analysis of the proteolytical cleavage of the p62 precursor protein suggested that transport in the presence of 10 mM caffeine was arrested at the membranes between the trans-Golgi and the plasma membrane.	Caffeine	183-191	nucleoporin 62	Homo sapiens	111-114
1306111-6	1992	For the CYP1A2 phenotype, the urinary molar ratio of [1,7-dimethylxanthine + 1,7-dimethyluric acid]/caffeine, taken at 4-5 h after caffeine ingestion, was identified from pharmacokinetic analyses of 12 subjects as being better correlated (r = 0.73; p = 0.007) with the rate constant for caffeine 3-demethylation than other previously suggested ratios.	Caffeine	100-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
1306111-11	1992	Induction of CYP1A2 by cigarette smoking was also confirmed by the increased caffeine metabolite ratios observed in the Arkansas and Italian smokers (blonde tobacco).	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19
1380386-13	1992	Pretreatment with caffeine (2 x 10(-2) M) in Ca(2+)-free medium abolished responses to endothelin-1 and sarafotoxin S6b.	Caffeine	18-26	endothelin-1	Capra hircus	87-99
1586287-2	1992	was mainly due to caffeine (CAF).	Caffeine	18-26	caffeine susceptibility	Mus musculus	28-31
1332001-6	1992	The ET-induced potentiation of the ATP motor response is not modified by tissue preincubation in Ca(2+)-free buffer plus 10-30 microM ryanodine or 5-20 mM caffeine.	Caffeine	155-163	endothelin 1	Rattus norvegicus	4-6
1524771-0	1992	Comments on Postma et al"s "The effect of caffeine on renal vein renin concentration in patients with renal arterial disease".	Caffeine	42-50	renin	Homo sapiens	65-70
1306111-0	1992	Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
1306111-0	1992	Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.	Caffeine	80-88	N-acetyltransferase 2	Homo sapiens	28-32
1306111-3	1992	Caffeine has also been shown to undergo 3-demethylation by CYP1A2, and it is further acetylated to 5-acetylamino-6-formylamino-3-methyluracil (AFMU) by the polymorphic NAT2.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-65
1306111-3	1992	Caffeine has also been shown to undergo 3-demethylation by CYP1A2, and it is further acetylated to 5-acetylamino-6-formylamino-3-methyluracil (AFMU) by the polymorphic NAT2.	Caffeine	0-8	N-acetyltransferase 2	Homo sapiens	168-172
1302044-0	1992	Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.	Caffeine	21-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
1302044-0	1992	Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.	Caffeine	21-29	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	109-115
1302044-2	1992	CYP1A2 alone was responsible for caffeine 3-demethylation and paraxanthine 7-demethylation; in addition, 1A2 catalysed virtually all reactions related to caffeine and its metabolites.	Caffeine	33-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
1302044-2	1992	CYP1A2 alone was responsible for caffeine 3-demethylation and paraxanthine 7-demethylation; in addition, 1A2 catalysed virtually all reactions related to caffeine and its metabolites.	Caffeine	154-162	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
1302044-3	1992	The metabolic profile of caffeine biotransformation by CYP1A2 averaged 81.5% for paraxanthine, 10.8% for theobromine and 5.4% for theophylline formation.	Caffeine	25-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
1302044-5	1992	The most striking finding was that CYP2E1 (the ethanol-inducible form) had major influences upon caffeine metabolism: in particular, it catalysed the formation of theophylline and theobromine from caffeine.	Caffeine	197-205	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	35-41
1302044-6	1992	Thus, the in vivo metabolite profiling of caffeine may reveal CYP2E1 activities in addition to the previously documented activities of CYP1A2, polymorphic N-acetyltransferase and xanthine oxidase.	Caffeine	42-50	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	62-68
1553257-1	1992	While making use of the inside-out membrane patch, we examined the effects of caffeine and heparin on unitary currents of the large conductance Ca(2+)-dependent K+ (maxi-K+) channel in the rabbit portal vein.	Caffeine	78-86	calcium-activated potassium channel subunit alpha-1	Oryctolagus cuniculus	165-181
1550224-6	1992	In medium containing 10 microM extracellular calcium, IGF-I did not cause any increase in [Ca2+]c. Likewise, blockade of IGF-induced calcium entry by either cobalt or tetramethrin abolished IGF-I action on [Ca2+]c. IGF-I-mediated oscillation was not affected by either ryanodine or caffeine, compounds that affect calcium-induced calcium release.	Caffeine	282-290	insulin like growth factor 1	Homo sapiens	190-195
1550224-6	1992	In medium containing 10 microM extracellular calcium, IGF-I did not cause any increase in [Ca2+]c. Likewise, blockade of IGF-induced calcium entry by either cobalt or tetramethrin abolished IGF-I action on [Ca2+]c. IGF-I-mediated oscillation was not affected by either ryanodine or caffeine, compounds that affect calcium-induced calcium release.	Caffeine	282-290	insulin like growth factor 1	Homo sapiens	190-195
1610485-0	1992	Evidence for hypothalamo-growth hormone dysfunction in panic disorder: profile of growth hormone (GH) responses to clonidine, yohimbine, caffeine, glucose, GRF and TRH in panic disorder patients versus healthy volunteers.	Caffeine	137-145	growth hormone 1	Homo sapiens	98-100
1610485-5	1992	Although stress-mediated increases in GH are thought to be a common correlate of stress in humans, our findings indicate that panic disorder patients have significantly blunted GH responses to clonidine, yohimbine, growth-hormone releasing factor, and caffeine compared to normal control subjects.	Caffeine	252-260	growth hormone 1	Homo sapiens	177-179
1343585-7	1992	This gives support to the hypothesis that if in rat ventricle SR-Ca pump (1 ATP hydrolyzed/2 Ca transported) is inhibited by caffeine cytosolic Ca would have to be removed by alternative mechanisms such as Na-Ca exchanger or sarcolemmal Ca pump both with a higher rate of ATP hydrolysis (1 ATP hydrolyzed/Ca transported) with the consequent decrease in muscle economy.	Caffeine	125-133	solute carrier family 8 member A1	Rattus norvegicus	206-221
1425875-6	1992	The ratio of paraxanthine formation to urinary caffeine concentration (= clearance equivalent) was about 2.2 ml.min-1.kg-1 in adults, and the corresponding ratios for theophylline and theobromine were 0.43 ml.min-1.kg-1 and 0.59 ml.min-1.kg-1, respectively.	Caffeine	47-55	CD59 molecule (CD59 blood group)	Homo sapiens	112-117
1555728-1	1992	The action of pharmacological drugs (caffeine, procaine, ruthenium red) which influenced the release of Ca2+ from endoplasmatic reticulum, the electrical responses of dog pancreatic acinar cells was investigated using intracellular glass microelectrodes.	Caffeine	37-45	carbonic anhydrase 2	Canis lupus familiaris	104-107
1309235-3	1992	Stimulation by F (controls) and F plus CA (ADA treated) in cortex slices was significantly inhibited by 200 microM caffeine (CAF) and by 10 microM 8-phenyltheophylline.	Caffeine	115-123	adenosine deaminase	Rattus norvegicus	43-46
1309235-3	1992	Stimulation by F (controls) and F plus CA (ADA treated) in cortex slices was significantly inhibited by 200 microM caffeine (CAF) and by 10 microM 8-phenyltheophylline.	Caffeine	125-128	adenosine deaminase	Rattus norvegicus	43-46
1522756-3	1992	The latency to obtain a 50% decrease in the amplitude of the CA1 population spike (CA1 PS) during a short- (5-10 min) lasting hypoxic period was significantly increased (P less than 0.01) by slice perfusion with caffeine (50 microM), DPCPX (0.2 microM), and by increasing (from 3 to 4 mM) the potassium concentration in the medium bathing the hippocampal slices.	Caffeine	212-220	carbonic anhydrase 1	Rattus norvegicus	61-64
1522756-3	1992	The latency to obtain a 50% decrease in the amplitude of the CA1 population spike (CA1 PS) during a short- (5-10 min) lasting hypoxic period was significantly increased (P less than 0.01) by slice perfusion with caffeine (50 microM), DPCPX (0.2 microM), and by increasing (from 3 to 4 mM) the potassium concentration in the medium bathing the hippocampal slices.	Caffeine	212-220	carbonic anhydrase 1	Rattus norvegicus	83-86
1522756-6	1992	The incidence of reappearance of the CA1 PS during reoxygenation after long- (45 min) lasting hypoxia was significantly increased (P less than 0.05) by slice perfusion with MK 801 (50 microM), while it was not significantly affected by slice perfusion with caffeine (50 microM) or DPCPX (0.2 microM) or L-PIA (0.2 microM) or CPA (0.05 microM) or CGS 21680 (5 microM).	Caffeine	257-265	carbonic anhydrase 1	Rattus norvegicus	37-40
1553258-5	1992	In the absence of thapsigargin both noradrenaline and caffeine also produced a transient increase of [Ca2+]i.	Caffeine	54-62	carbonic anhydrase 2	Rattus norvegicus	102-105
1553258-8	1992	These results show that thapsigargin releases Ca2+ from the noradrenaline and caffeine-sensitive stores.	Caffeine	78-86	carbonic anhydrase 2	Rattus norvegicus	46-49
1531451-5	1992	Moreover, okadaic acid and caffeine, which uncouple the dependence of mitosis on the completion of S phase, increase unphosphorylated p34cdc2 by attenuating tyrosine kinase function.	Caffeine	27-35	cyclin-dependent kinase 1 L homeolog	Xenopus laevis	134-141
1425653-2	1992	After a test to determine maximal oxygen consumption (VO2max) each subject underwent three test sessions at 55% VO2max either in a control condition (CON) or with the CAF1 or CAF2 dose of caffeine.	Caffeine	188-196	CCR4-NOT transcription complex subunit 8	Homo sapiens	175-179
1425653-7	1992	Caffeine ingestion caused the greatest elevation above resting levels being 1.89 (SEM 0.19) mmol.l-1 and 1.96 (SEM 0.22) mmol.l-1 for the CAF1 and CAF2 trials, respectively.	Caffeine	0-8	chromatin assembly factor 1 subunit A	Homo sapiens	138-142
1425653-7	1992	Caffeine ingestion caused the greatest elevation above resting levels being 1.89 (SEM 0.19) mmol.l-1 and 1.96 (SEM 0.22) mmol.l-1 for the CAF1 and CAF2 trials, respectively.	Caffeine	0-8	CCR4-NOT transcription complex subunit 8	Homo sapiens	147-151
1810598-11	1991	These results suggest that ET-1 may induce phosphorylation of an unknown protein either without an increase in myoplasmic Ca2 + concentration or, alternatively, with mobilization of intracellular Ca2+ from noradrenaline- and caffeine-insensitive Ca2 + sources, through a mechanism different from that of phorbol ester.	Caffeine	225-233	endothelin 1	Rattus norvegicus	27-31
1815652-0	1991	The effect of caffeine on renal vein renin concentration in patients with renal arterial disease.	Caffeine	14-22	renin	Homo sapiens	37-42
1815652-1	1991	The aim of this study was to investigate whether caffeine stimulates selectively renal vein renin levels at the side of unilateral stenosis in patients with renovascular hypertension.	Caffeine	49-57	renin	Homo sapiens	92-97
1914371-6	1991	This effect could not be explained by any pharmacokinetic interaction between the two drugs and occurred even though phenylpropanolamine attenuated the epinephrine and renin response to caffeine.	Caffeine	186-194	renin	Homo sapiens	168-173
1933891-5	1991	Caffeine treatment blocks both the G1 arrest and the induction of p53 protein after gamma-irradiation, thus suggesting that blocking the induction of p53 protein may contribute to the previously observed effects of caffeine on cell cycle changes after DNA damage.	Caffeine	0-8	tumor protein p53	Homo sapiens	66-69
1933891-5	1991	Caffeine treatment blocks both the G1 arrest and the induction of p53 protein after gamma-irradiation, thus suggesting that blocking the induction of p53 protein may contribute to the previously observed effects of caffeine on cell cycle changes after DNA damage.	Caffeine	0-8	tumor protein p53	Homo sapiens	150-153
1933891-5	1991	Caffeine treatment blocks both the G1 arrest and the induction of p53 protein after gamma-irradiation, thus suggesting that blocking the induction of p53 protein may contribute to the previously observed effects of caffeine on cell cycle changes after DNA damage.	Caffeine	215-223	tumor protein p53	Homo sapiens	66-69
1933891-5	1991	Caffeine treatment blocks both the G1 arrest and the induction of p53 protein after gamma-irradiation, thus suggesting that blocking the induction of p53 protein may contribute to the previously observed effects of caffeine on cell cycle changes after DNA damage.	Caffeine	215-223	tumor protein p53	Homo sapiens	150-153
1954683-7	1991	Inhibitors (ryanodine and caffeine) and promoters (intracellularly dialyzed inositol 1,4,5-trisphosphate) of sarcoplasmic reticulum Ca2+ release decreased and increased, respectively, the magnitude of the early inward tail current.	Caffeine	26-34	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	132-135
1834555-7	1991	The kinetics of ANF release observed during caffeine (10(-6) to 10(-2) M) treatment was similar to that seen in atrial preparations without treatment.	Caffeine	44-52	natriuretic peptide A	Rattus norvegicus	16-19
1657437-7	1991	This sustained steady-state rise in [Ca2+]i occurred even in the absence of extracellular Ca2+ but was virtually abolished by a 20-second preexposure to 10 mM caffeine, suggesting that the major source of this Ca2+ was the sarcoplasmic reticulum.	Caffeine	159-167	carbonic anhydrase 2	Oryctolagus cuniculus	37-40
1934864-0	1991	Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities.	Caffeine	7-15	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	45-51
1934864-1	1991	Caffeine was used as a metabolic probe to screen healthy subjects for their activities of two enzymes, deduced to be CYP1A2 (an inducible cytochrome P450) and xanthine oxidase.	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	117-123
1934864-2	1991	A longitudinal study revealed modest effects of caffeine dose, ethanol intake, and time-of-day on the CYP1A2 index, without any effect on the xanthine oxidase index.	Caffeine	48-56	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-108
1959784-7	1991	The addition of 1 mM caffeine to the culture media, starting immediately postirradiation, prevented G2 arrest, promoting a rapid traverse of cells through G2A to G2B to G1, which was associated with diminished survival.	Caffeine	21-29	G protein-coupled receptor 132	Homo sapiens	155-158
1650299-3	1991	In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%).	Caffeine	38-46	angiotensinogen	Rattus norvegicus	239-253
1742018-2	1991	Caffeine (1-30 mM) lowers the resting [Ca2+]i by reducing the entry of Ca2+ and inhibits completely the mobilization of Ca2+ by arginine vasopressin.	Caffeine	0-8	arginine vasopressin	Homo sapiens	137-148
1922970-0	1991	Caffeine-induced epileptic discharges in CA3 neurons of hippocampal slices of the guinea pig.	Caffeine	0-8	carbonic anhydrase 3	Cavia porcellus	41-44
1922970-2	1991	When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared.	Caffeine	31-39	carbonic anhydrase 3	Cavia porcellus	115-118
1796750-4	1991	In contrast, osteocalcin levels, alkaline phosphatase activity, and total calcium levels showed a dose-related decrease in cultures treated with caffeine.	Caffeine	145-153	bone gamma-carboxyglutamate protein	Gallus gallus	13-24
1798317-6	1991	During the caffeine trial the athletes ran further than either the control or placebo conditions (p less than 0.05).	Caffeine	11-19	RAN, member RAS oncogene family	Homo sapiens	39-42
1650299-3	1991	In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%).	Caffeine	97-105	angiotensinogen	Rattus norvegicus	239-253
1650299-3	1991	In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%).	Caffeine	97-105	angiotensinogen	Rattus norvegicus	239-253
1650299-3	1991	In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%).	Caffeine	97-105	angiotensinogen	Rattus norvegicus	239-253
1782213-8	1991	The PAF response was also inhibited by ruthenium red or octanol and potentiated by caffeine, suggesting that CICR plays a physiological role in these cells.	Caffeine	83-91	PCNA clamp associated factor	Homo sapiens	4-7
1718937-0	1991	Effects of BAY K 8644, nifedipine, and low Ca2+ on halothane and caffeine potentiation.	Caffeine	65-73	carbonic anhydrase 2	Homo sapiens	43-46
1718937-1	1991	The purpose of this investigation was to examine the effects of the Ca2+ agonist BAY K 8644 and the Ca2+ antagonist nifedipine on halothane- and caffeine-induced twitch potentiation of mammalian skeletal muscle.	Caffeine	145-153	carbonic anhydrase 2	Homo sapiens	68-71
1718937-1	1991	The purpose of this investigation was to examine the effects of the Ca2+ agonist BAY K 8644 and the Ca2+ antagonist nifedipine on halothane- and caffeine-induced twitch potentiation of mammalian skeletal muscle.	Caffeine	145-153	carbonic anhydrase 2	Homo sapiens	100-103
1830667-8	1991	In hamster cells, the hyperphosphorylated form of p34cdc2 was complexed with cyclin B and underwent tyrosine dephosphorylation during caffeine-induced premature mitosis.	Caffeine	134-142	cyclin dependent kinase 1	Homo sapiens	50-57
1865359-7	1991	After 7 days of caffeine abstinence, the adenosine analog 5"-N-ethylcarboxamidoadenosine produced a dose-dependent inhibition of thrombin-induced aggregation (EC50 = 69 nM).	Caffeine	16-24	coagulation factor II, thrombin	Homo sapiens	129-137
1774773-5	1991	During caffeine-induced calcium-dependent calcium release of Ca2+ from intracellular stores a stimulation of calcium extrusion took place, reaching the velocity of 5.0 microM/sec per cell volume.	Caffeine	7-15	carbonic anhydrase 2	Homo sapiens	61-64
1860718-7	1991	Six weeks of caffeine administration increased blood pressure, blood urea nitrogen, serum creatinine, plasma renin activity, and plasma irET-1 in the 2K1C rats but not in the sham-operated rats.	Caffeine	13-21	renin	Rattus norvegicus	109-114
1706431-2	1991	The rate of 45Ca++ efflux from HSR vesicles was accelerated markedly by MBED or caffeine in a concentration-dependent manner.	Caffeine	80-88	HSR	Homo sapiens	31-34
2058791-9	1991	Addition of caffeine to ethanol reduced this enhanced EGF binding by 45%.	Caffeine	12-20	epidermal growth factor	Rattus norvegicus	54-57
2058791-11	1991	It is concluded that (1) ethanol blocks EGF-mediated replication accompanied by a reduction in DNA synthesis, (2) caffeine alone at low concentrations has the opposite effect and can actually potentiate the EGF-mediated mitogenic response, (3) caffeine in combination with ethanol acts synergistically to reduce RFH replication.	Caffeine	114-122	epidermal growth factor	Rattus norvegicus	207-210
2058791-11	1991	It is concluded that (1) ethanol blocks EGF-mediated replication accompanied by a reduction in DNA synthesis, (2) caffeine alone at low concentrations has the opposite effect and can actually potentiate the EGF-mediated mitogenic response, (3) caffeine in combination with ethanol acts synergistically to reduce RFH replication.	Caffeine	244-252	epidermal growth factor	Rattus norvegicus	40-43
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Caffeine	104-112	vasoactive intestinal peptide	Rattus norvegicus	15-44
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Caffeine	104-112	vasoactive intestinal peptide	Rattus norvegicus	46-49
1657046-1	1991	In rat ventricular cardiomyocytes loaded with the fluorescent Ca2+ indicator Indo-1/AM, the delta opioid receptor agonist Leu-Enk caused Cai oscillations and abolished the caffeine-induced Cai transient.	Caffeine	172-180	proenkephalin	Rattus norvegicus	126-129
1706431-3	1991	The 50% effective concentrations of MBED and caffeine were approximately 1 microM and 1 mM, respectively, indicating that MBED is 1000 times more potent than caffeine in HSR.	Caffeine	45-53	HSR	Homo sapiens	170-173
1706431-3	1991	The 50% effective concentrations of MBED and caffeine were approximately 1 microM and 1 mM, respectively, indicating that MBED is 1000 times more potent than caffeine in HSR.	Caffeine	158-166	HSR	Homo sapiens	170-173
2005584-11	1991	These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system.	Caffeine	168-176	renin	Rattus norvegicus	209-214
2005584-0	1991	Caffeine potentiates vasodilator-induced renin release.	Caffeine	0-8	renin	Rattus norvegicus	41-46
2005584-2	1991	The clinical significance of this is that caffeine, a widely consumed adenosine receptor antagonist, could augment renin release responses to diseases such as renovascular hypertension, liver cirrhosis and heart failure and to therapeutic maneuvers such as salt restriction, diuretics and vasodilators.	Caffeine	42-50	renin	Rattus norvegicus	115-120
2005584-3	1991	Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion.	Caffeine	0-8	renin	Rattus norvegicus	221-226
2005584-3	1991	Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion.	Caffeine	198-206	renin	Rattus norvegicus	221-226
2005584-4	1991	The purpose of this study was to document the effects of caffeine on renin release responses to a vasodilator and to investigate what mechanisms were responsible for any augmentation of vasodilator-induced renin secretion.	Caffeine	57-65	renin	Rattus norvegicus	69-74
2005584-7	1991	Caffeine and DPSPX increased base-line plasma renin activity to a similar extent regardless of whether the animals were pretreated with propranolol.	Caffeine	0-8	renin	Rattus norvegicus	46-51
2003276-0	1991	Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives.	Caffeine	38-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
2005584-8	1991	In rats with an intact beta adrenergic system, caffeine, but not DPSPX, increased the renin release response to low-dose hydralazine (1 mg/kg).	Caffeine	47-55	renin	Rattus norvegicus	86-91
2005584-11	1991	These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system.	Caffeine	28-36	renin	Rattus norvegicus	57-62
2003276-1	1991	The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined.	Caffeine	49-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
2003276-1	1991	The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined.	Caffeine	49-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
2001251-6	1991	A small Ca2+ transient still remains under experimental conditions designed to prevent Ca2+ influx from external medium (low-Ca2+ high-Mg2+ medium containing La3+) and after depletion of the sarcoplasmic-reticulum Ca2+ load with caffeine.	Caffeine	229-237	carbonic anhydrase 2	Rattus norvegicus	8-11
1995187-8	1991	The number and size of G6Pd foci decreased to the same extent with the ingestion of a lab chow supplemented with 0.2% of caffeine as with the diet restriction.	Caffeine	121-129	glucose-6-phosphate dehydrogenase 2	Mus musculus	23-27
2226801-3	1990	Xenopus oocytes injected with mRNA derived from the cardiac ryanodine receptor cDNA exhibit Ca2(+)-dependent Cl- current in response to caffeine, which indicates the formation of functional calcium release channels.	Caffeine	136-144	ryanodine receptor 2	Oryctolagus cuniculus	52-78
1847890-4	1991	The results show that caffeine effectively scavenges .OH with a reaction rate constant of approximately 5.9 x 10(9) M-1 sec-1 that is comparable with those of other efficient .OH radical scavengers.	Caffeine	22-30	secretory blood group 1, pseudogene	Homo sapiens	120-125
1808966-1	1991	Caffeine is mainly metabolized by 3-methylcholanthreneinducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by the phenobarbital inducible cytochrome P-450 family.	Caffeine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-80
1808966-2	1991	Therefore the elimination of caffeine from serum and the elimination of the main metabolites of metamizol in urine reflect the activity of these two cytochrome P-450 families.	Caffeine	29-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	149-165
2261986-2	1990	The repetitive spikes, which are apparently dependent upon the establishment of cell coupling, are also induced by caffeine, indicating that they may be due to an oscillatory release of Ca2+ from the endoplasmic reticulum, and may not involve oscillations in inositol phosphates.	Caffeine	115-123	carbonic anhydrase 2	Homo sapiens	186-189
2173454-9	1990	Furthermore, PTX, aminophylline (AMPH), caffeine, and forskolin attenuate TNF-induced EC cytotoxicity only in the presence of PMN (p less than 0.05).	Caffeine	40-48	tumor necrosis factor	Bos taurus	74-77
2173454-13	1990	Furthermore, PTX, AMPH, caffeine, and forskolin can attenuate TNF-induced EC injury in the presence of PMN, whereas DBcAMP attenuates TNF-induced EC injury with and without PMN.	Caffeine	24-32	tumor necrosis factor	Bos taurus	62-65
1981505-0	1990	Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes.	Caffeine	51-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-40
1981505-7	1990	The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation.	Caffeine	43-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-216
1981505-7	1990	The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation.	Caffeine	240-248	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-216
2086772-20	1990	It is suggested that the increase of systolic [Ca2+]i is due to caffeine increasing the fraction of the SR Ca2+ content released during the twitch.	Caffeine	64-72	carbonic anhydrase 2	Rattus norvegicus	47-50
2086772-20	1990	It is suggested that the increase of systolic [Ca2+]i is due to caffeine increasing the fraction of the SR Ca2+ content released during the twitch.	Caffeine	64-72	carbonic anhydrase 2	Rattus norvegicus	107-110
2086772-22	1990	The above results concerning both diastolic and systolic [Ca2+]i can be explained by a model in which caffeine increases the affinity with which Ca2+ ions activate Ca2(+)-induced Ca2+ release.	Caffeine	102-110	carbonic anhydrase 2	Rattus norvegicus	58-61
2086772-22	1990	The above results concerning both diastolic and systolic [Ca2+]i can be explained by a model in which caffeine increases the affinity with which Ca2+ ions activate Ca2(+)-induced Ca2+ release.	Caffeine	102-110	carbonic anhydrase 2	Rattus norvegicus	145-148
2086772-22	1990	The above results concerning both diastolic and systolic [Ca2+]i can be explained by a model in which caffeine increases the affinity with which Ca2+ ions activate Ca2(+)-induced Ca2+ release.	Caffeine	102-110	carbonic anhydrase 2	Rattus norvegicus	145-148
2086772-22	1990	The above results concerning both diastolic and systolic [Ca2+]i can be explained by a model in which caffeine increases the affinity with which Ca2+ ions activate Ca2(+)-induced Ca2+ release.	Caffeine	102-110	carbonic anhydrase 2	Rattus norvegicus	145-148
2086772-23	1990	At high enough [caffeine], the threshold [Ca2+]i for regenerative Ca2(+)-induced Ca2+ release will be reduced to below the resting [Ca2+]i thus producing a diastolic increase of [Ca2+]i.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	42-45
2086772-23	1990	At high enough [caffeine], the threshold [Ca2+]i for regenerative Ca2(+)-induced Ca2+ release will be reduced to below the resting [Ca2+]i thus producing a diastolic increase of [Ca2+]i.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	66-69
2086772-23	1990	At high enough [caffeine], the threshold [Ca2+]i for regenerative Ca2(+)-induced Ca2+ release will be reduced to below the resting [Ca2+]i thus producing a diastolic increase of [Ca2+]i.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	66-69
2086772-23	1990	At high enough [caffeine], the threshold [Ca2+]i for regenerative Ca2(+)-induced Ca2+ release will be reduced to below the resting [Ca2+]i thus producing a diastolic increase of [Ca2+]i.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	66-69
2086772-23	1990	At high enough [caffeine], the threshold [Ca2+]i for regenerative Ca2(+)-induced Ca2+ release will be reduced to below the resting [Ca2+]i thus producing a diastolic increase of [Ca2+]i.	Caffeine	16-24	carbonic anhydrase 2	Rattus norvegicus	66-69
2004666-6	1991	When intracellular Ca2+ was mobilized by caffeine the rise in nuclear [Ca2+]i was again greater than in any other region of the neuron.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	19-22
2004666-6	1991	When intracellular Ca2+ was mobilized by caffeine the rise in nuclear [Ca2+]i was again greater than in any other region of the neuron.	Caffeine	41-49	carbonic anhydrase 2	Homo sapiens	71-74
1845789-7	1991	Caffeine intake was inversely correlated with free estradiol and positively correlated with SHBG.	Caffeine	0-8	sex hormone binding globulin	Homo sapiens	92-96
1898965-9	1991	The caffeine-induced [Ca2+]i rise became smaller when the cells were pretreated with the inositol trisphosphate-generating agonists, methacholine and bradykinin.	Caffeine	4-12	kininogen 1	Bos taurus	150-160
1988669-0	1991	Caffeine potentiates the renin response to diazoxide in man.	Caffeine	0-8	renin	Homo sapiens	25-30
1988669-4	1991	The ability of the adenosine receptor blocker, caffeine, to augment renin release in response to the vasodilator, diazoxide, has been investigated in eight normal subjects in a double-blind, placebo-controlled, cross-over study.	Caffeine	47-55	renin	Homo sapiens	68-73
1988669-11	1991	Although there was no difference in plasma diazoxide levels, maximal pulse or BP response to diazoxide between the two arms of the study, the renin response was significantly greater in the presence of caffeine.	Caffeine	202-210	renin	Homo sapiens	142-147
1701258-5	1990	The effect of cAMP agonists on recombination appears to reflect an increase in cellular recombination activity, as indicated by the caffeine-induced rise in the level of mRNA from the recombination-activating genes RAG1 and RAG2.	Caffeine	132-140	recombination activating 1	Homo sapiens	215-219
1701258-5	1990	The effect of cAMP agonists on recombination appears to reflect an increase in cellular recombination activity, as indicated by the caffeine-induced rise in the level of mRNA from the recombination-activating genes RAG1 and RAG2.	Caffeine	132-140	recombination activating 2	Homo sapiens	224-228
2086772-0	1990	A mechanism for the effects of caffeine on Ca2+ release during diastole and systole in isolated rat ventricular myocytes.	Caffeine	31-39	carbonic anhydrase 2	Rattus norvegicus	43-46
2086772-4	1990	Caffeine (at concentrations of 1 mM or above) produced a transient increase of resting [Ca2+]i attributed to the release of Ca2+ ions from the sarcoplasmic reticulum (SR).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	88-91
2086772-4	1990	Caffeine (at concentrations of 1 mM or above) produced a transient increase of resting [Ca2+]i attributed to the release of Ca2+ ions from the sarcoplasmic reticulum (SR).	Caffeine	0-8	carbonic anhydrase 2	Rattus norvegicus	124-127
2086772-5	1990	Simultaneous measurement of [caffeine]i showed that the Ca2+ release only began when [caffeine]i had risen to about 1 mM.	Caffeine	29-37	carbonic anhydrase 2	Rattus norvegicus	56-59
2086772-5	1990	Simultaneous measurement of [caffeine]i showed that the Ca2+ release only began when [caffeine]i had risen to about 1 mM.	Caffeine	86-94	carbonic anhydrase 2	Rattus norvegicus	56-59
2086772-9	1990	If external Ca2+ was removed the release of Ca2+ produced by caffeine was delayed such that [caffeine]i rose to a greater concentration before release was initiated.	Caffeine	61-69	carbonic anhydrase 2	Rattus norvegicus	12-15
2086772-9	1990	If external Ca2+ was removed the release of Ca2+ produced by caffeine was delayed such that [caffeine]i rose to a greater concentration before release was initiated.	Caffeine	61-69	carbonic anhydrase 2	Rattus norvegicus	44-47
2086772-9	1990	If external Ca2+ was removed the release of Ca2+ produced by caffeine was delayed such that [caffeine]i rose to a greater concentration before release was initiated.	Caffeine	93-101	carbonic anhydrase 2	Rattus norvegicus	12-15
2086772-9	1990	If external Ca2+ was removed the release of Ca2+ produced by caffeine was delayed such that [caffeine]i rose to a greater concentration before release was initiated.	Caffeine	93-101	carbonic anhydrase 2	Rattus norvegicus	44-47
2086772-10	1990	This suggests that an increase of [Ca2+]i increases the efficacy of caffeine to release Ca2+ ions from the SR. 4.	Caffeine	68-76	carbonic anhydrase 2	Rattus norvegicus	35-38
2086772-10	1990	This suggests that an increase of [Ca2+]i increases the efficacy of caffeine to release Ca2+ ions from the SR. 4.	Caffeine	68-76	carbonic anhydrase 2	Rattus norvegicus	88-91
2086772-15	1990	If the exposure to caffeine was prolonged, this increase of systolic [Ca2+]i and contraction was completely transient.	Caffeine	19-27	carbonic anhydrase 2	Rattus norvegicus	70-73
2086772-16	1990	On removal of caffeine, systolic [Ca2+]i and contraction decreased to below control before recovering.	Caffeine	14-22	carbonic anhydrase 2	Rattus norvegicus	34-37
2284203-4	1990	These results suggest that prenatal exposure to AVP or caffeine produced sexually dimorphic effects on learning and that the effects are specific to the structure of AVP.	Caffeine	55-63	arginine vasopressin	Rattus norvegicus	166-169
1706809-6	1990	After removal of intracellular Ca2+ with caffeine in the artery, endothelin-1 still evoked a contraction (17 +/- 3%, n = 3; p less than 0.005 vs. control), while in the vein the response was abolished.	Caffeine	41-49	endothelin 1	Homo sapiens	65-77
2234463-6	1990	With the administration of a single oral dose of caffeine, normal subjects present an increase in plasma concentrations of beta-E, while in patients with chronic migraine, the response is significantly lower.	Caffeine	49-57	proopiomelanocortin	Homo sapiens	123-129
2130600-10	1990	These results indicate that norepinephrine completely depletes caffeine-sensitive Ca2 stores but caffeine only partially depletes norepinephrine-sensitive Ca2+ stores.	Caffeine	63-71	carbonic anhydrase 2	Rattus norvegicus	82-85
2130600-10	1990	These results indicate that norepinephrine completely depletes caffeine-sensitive Ca2 stores but caffeine only partially depletes norepinephrine-sensitive Ca2+ stores.	Caffeine	97-105	carbonic anhydrase 2	Rattus norvegicus	155-158
2369137-7	1990	We conducted the present study to evaluate the combination effect of caffeine and CDDP on the human lung adenocarcinoma cell line PC9/P and its CDDP resistant cell line PC9/R.	Caffeine	69-77	proprotein convertase subtilisin/kexin type 9	Homo sapiens	130-133
2165398-0	1990	Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.	Caffeine	92-100	C-reactive protein	Homo sapiens	13-31
2165398-1	1990	Induction of C-reactive protein (CRP) by conditioned medium from lipopolysaccharide-stimulated human monocytes in two human hepatoma-cell lines, Hep 3B and NPLC/PRF/5, was potentiated 3-6-fold by the methylxanthine caffeine.	Caffeine	215-223	C-reactive protein	Homo sapiens	13-31
2165398-1	1990	Induction of C-reactive protein (CRP) by conditioned medium from lipopolysaccharide-stimulated human monocytes in two human hepatoma-cell lines, Hep 3B and NPLC/PRF/5, was potentiated 3-6-fold by the methylxanthine caffeine.	Caffeine	215-223	C-reactive protein	Homo sapiens	33-36
2165398-11	1990	Caffeine similarly potentiated induction of CRP by these defined cytokine signals in these two cell lines.	Caffeine	0-8	C-reactive protein	Homo sapiens	44-47
2165398-13	1990	Thus these results indicate that the mechanism by which caffeine potentiates CRP induction by cytokines appears to be independent of increases in intracellular concentrations of the two second messengers, cyclic AMP and Ca2+; the precise nature of this mechanism is unclear at the present time.	Caffeine	56-64	C-reactive protein	Homo sapiens	77-80
2165398-15	1990	The differential response of CRP and SAA to caffeine is of particular interest, since induction of both of these two major acute-phase proteins can be accomplished by identical extracellular signals.	Caffeine	44-52	C-reactive protein	Homo sapiens	29-32
2165398-15	1990	The differential response of CRP and SAA to caffeine is of particular interest, since induction of both of these two major acute-phase proteins can be accomplished by identical extracellular signals.	Caffeine	44-52	serum amyloid A1 cluster	Homo sapiens	37-40
2369137-7	1990	We conducted the present study to evaluate the combination effect of caffeine and CDDP on the human lung adenocarcinoma cell line PC9/P and its CDDP resistant cell line PC9/R.	Caffeine	69-77	proprotein convertase subtilisin/kexin type 9	Homo sapiens	169-172
2369137-9	1990	Caffeine enhanced the effect of CDDP on PC9/P synergistically.	Caffeine	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	40-43
2369137-12	1990	The data indicate that caffeine does not overcome the resistance of PC9/R, whereas caffeine enters PC9/R.	Caffeine	83-91	proprotein convertase subtilisin/kexin type 9	Homo sapiens	99-102
2173187-2	1990	Ca2(+)-transporting system of sarcoplasmic reticulum terminal cisternae membranes from the ischemic myocardium was found to be more sensitive to Ca2+ and caffeine action, inhibiting Ca2+ uptake velocity, as compared to control.	Caffeine	154-162	carbonic anhydrase 2	Rattus norvegicus	0-3
1692207-8	1990	In addition, caffeine, which releases Ca2+ from intracellular stores in other cell types, caused an increase in [Ca2+]c in GH4C1 cells, but had no effect on a subsequent spike in [Ca2+]c induced by TRH or thapsigargin.	Caffeine	13-21	thyrotropin releasing hormone	Rattus norvegicus	198-201
2162056-3	1990	Lowering intracellular cAMP levels with caffeine or progesterone increased cellular and secreted PDE activities 2-fold, increased stalk cell differentiation, and inhibited spore differentiation.	Caffeine	40-48	cathelicidin antimicrobial peptide	Homo sapiens	23-27
2162056-5	1990	Simultaneous exposure to 8-Br-cAMP and caffeine gave intermediate PDE activities as would be expected if 8-Br-cAMP entered the cell and bypassed the caffeine-mediated block to adenylate cyclase activation.	Caffeine	39-47	cathelicidin antimicrobial peptide	Homo sapiens	110-114
2162056-5	1990	Simultaneous exposure to 8-Br-cAMP and caffeine gave intermediate PDE activities as would be expected if 8-Br-cAMP entered the cell and bypassed the caffeine-mediated block to adenylate cyclase activation.	Caffeine	149-157	cathelicidin antimicrobial peptide	Homo sapiens	30-34
2162056-5	1990	Simultaneous exposure to 8-Br-cAMP and caffeine gave intermediate PDE activities as would be expected if 8-Br-cAMP entered the cell and bypassed the caffeine-mediated block to adenylate cyclase activation.	Caffeine	149-157	cathelicidin antimicrobial peptide	Homo sapiens	110-114
1974194-0	1990	Effect of growth hormone on caffeine metabolism in hypophysectomized rats.	Caffeine	28-36	gonadotropin releasing hormone receptor	Rattus norvegicus	10-24
2213688-5	1990	The post-irradiation damage and its modification by caffeine and t-BuOH was assessed in terms of 8-day-old seedling injury, peroxidase activity and total peroxides in the 8-day-old seedlings.	Caffeine	52-60	prx7	Hordeum vulgare	124-134
2309921-3	1990	Photolysis of Nitr-5 to produce a small jump in [Ca2+] from pCa 6.8 to 6.4 induced a large and rapid force response (t1/2 = 0.89 s at 12 degrees C); the source of the Ca2+ that activated the myofibrils was judged to be the SR, since it was blocked by 0.1 mM ryanodine or 5 mM caffeine.	Caffeine	276-284	carbonic anhydrase 2	Rattus norvegicus	49-52
2317916-1	1990	Caffeine and ryanodine are known to modulate oscillatory release of Ca2+ from the sarcoplasmic reticulum.	Caffeine	0-8	carbonic anhydrase 2	Canis lupus familiaris	68-71
2345041-6	1990	The presence of 800 microM propranolol immobilized all sperm within 4 h. Caffeine at 1.7 and 5 mM, increased VCL and ALHMEAN.	Caffeine	73-81	vinculin	Homo sapiens	109-112
2307116-0	1990	Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.	Caffeine	138-146	complement factor D	Rattus norvegicus	8-15
2352535-8	1990	An increased duration of acid GER was observed during the SPP under therapy with theophylline and even more distinct with caffeine treatment.	Caffeine	122-130	GER	Homo sapiens	30-33
2317821-8	1990	Caffeine, a known inhibitor of postreplication repair, decreased the frequency of mutation induction at the hypoxanthine-guanine phosphoribosyltransferase locus by 40-55% in CHO-77256 but not in CHO-UV-1.	Caffeine	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	108-154
2160618-7	1990	Caffeine (1-40 mmol/l) inhibited the phosphorylation of 20 kDa myosin light chain (MLC) in native actomyosin preparation and the inhibition was enhanced by decreasing the ATP concentration in the reaction medium.	Caffeine	0-8	myosin, heavy chain 15	Gallus gallus	63-69
2160618-7	1990	Caffeine (1-40 mmol/l) inhibited the phosphorylation of 20 kDa myosin light chain (MLC) in native actomyosin preparation and the inhibition was enhanced by decreasing the ATP concentration in the reaction medium.	Caffeine	0-8	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	83-86
2160618-11	1990	These results indicate that caffeine inhibits smooth muscle contraction by a direct inhibition of MLC kinase and actin-myosin interaction.	Caffeine	28-36	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	98-101
2160618-11	1990	These results indicate that caffeine inhibits smooth muscle contraction by a direct inhibition of MLC kinase and actin-myosin interaction.	Caffeine	28-36	actin, beta	Gallus gallus	113-118
2160618-11	1990	These results indicate that caffeine inhibits smooth muscle contraction by a direct inhibition of MLC kinase and actin-myosin interaction.	Caffeine	28-36	myosin, heavy chain 15	Gallus gallus	119-125
1970433-4	1990	These results show that no relation exists between the effect of a drug on spontaneous motor activity on one hand and the social behavioural deficit on the other hand; they confirm the high specificity of the effect of agonists of the 5-HT1B receptors in the social behavioural deficit test; they suggest that an increase in the social behavioural deficit as elicited by amphetamine and caffeine may result from an increase in attention and anxious vigilance.	Caffeine	387-395	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	235-241
2310395-5	1990	In the presence of caffeine (20 mM), the second-phase Ca2+ response to a hypotonic challenge occurred earlier immediately after the first-phase response.	Caffeine	19-27	carbonic anhydrase 2	Homo sapiens	54-57
2309921-3	1990	Photolysis of Nitr-5 to produce a small jump in [Ca2+] from pCa 6.8 to 6.4 induced a large and rapid force response (t1/2 = 0.89 s at 12 degrees C); the source of the Ca2+ that activated the myofibrils was judged to be the SR, since it was blocked by 0.1 mM ryanodine or 5 mM caffeine.	Caffeine	276-284	carbonic anhydrase 2	Rattus norvegicus	167-170
2328393-16	1990	Relaxant effects of caffeine can be explained by mechanisms leading to a decrease in both the cytoplasmic free Ca2+ concentration and the Ca2 +-sensitivity of the contractile machinery.	Caffeine	20-28	carbonic anhydrase 2	Rattus norvegicus	111-114
2328393-8	1990	In Ca2(+)-free solution, various substances (oxytocin, sodium orthovanadate and prostaglandin E2) evoked sustained contractions that were suppressed by caffeine (5-10 mM).	Caffeine	152-160	carbonic anhydrase 2	Rattus norvegicus	3-6
2328393-16	1990	Relaxant effects of caffeine can be explained by mechanisms leading to a decrease in both the cytoplasmic free Ca2+ concentration and the Ca2 +-sensitivity of the contractile machinery.	Caffeine	20-28	carbonic anhydrase 2	Rattus norvegicus	138-141
2328393-9	1990	When caffeine (greater than 5 mM) was applied during Ca2(+)-loading of the tissue (2.1 mM Ca2+, 5 min) in the presence of a K(+)-rich solution, the subsequent transient contraction induced by a short application (10s) of oxytocin (22.5 nM) in Ca-free solution was reduced (63 +/- 3.5% reduction for 20 mM caffeine, n = 4).	Caffeine	5-13	carbonic anhydrase 2	Rattus norvegicus	53-56
2313935-4	1990	Depletion of the caffeine-sensitive Ca2+ store with ryanodine (3 x 10(-5) M) and repetitive applications of caffeine (2.5 x 10(-2) M) scarcely affected contractile and Ca2+i responses to histamine.	Caffeine	17-25	carbonic anhydrase 2	Homo sapiens	36-39
2328393-9	1990	When caffeine (greater than 5 mM) was applied during Ca2(+)-loading of the tissue (2.1 mM Ca2+, 5 min) in the presence of a K(+)-rich solution, the subsequent transient contraction induced by a short application (10s) of oxytocin (22.5 nM) in Ca-free solution was reduced (63 +/- 3.5% reduction for 20 mM caffeine, n = 4).	Caffeine	5-13	carbonic anhydrase 2	Rattus norvegicus	90-93
2328393-11	1990	In saponin-skinned strips, application of caffeine (5-10 mM) during loading of the Ca2(+)-store increased the subsequent contraction induced by myo-inositol 1,4,5 trisphosphate (IP3, 10 microM).	Caffeine	42-50	carbonic anhydrase 2	Rattus norvegicus	83-86
2313935-6	1990	When histamine or caffeine was repetitively applied in Ca2(+)-free medium, the first application produced an increase in Ca2+i but the second application produced no increase.	Caffeine	18-26	carbonic anhydrase 2	Homo sapiens	55-58
2138554-1	1990	The triple ATPase activities of washed spermatozoa of oligoasthenospermic men (but not of normals) were enhanced by the addition of caffeine and theophylline, which are known to have a stimulating effect on sperm motility.	Caffeine	132-140	dynein axonemal heavy chain 8	Homo sapiens	11-17
2313935-6	1990	When histamine or caffeine was repetitively applied in Ca2(+)-free medium, the first application produced an increase in Ca2+i but the second application produced no increase.	Caffeine	18-26	carbonic anhydrase 2	Homo sapiens	121-124
2313935-7	1990	Although caffeine increased Ca2+i after repetitive histamine applications, histamine failed to increase Ca2+i after repetitive caffeine applications in Ca2(+)-free medium.	Caffeine	9-17	carbonic anhydrase 2	Homo sapiens	28-31
2313935-8	1990	These results indicate that vascular contraction induced by histamine may involve the following mechanisms: an increase in Ca2+ influx through Ca2+ channels, release of Ca2+ from the intracellular Ca2+ store which has an interaction with the caffeine-sensitive Ca2+ store, and sensitization of contractile proteins to Ca2+.	Caffeine	242-250	carbonic anhydrase 2	Homo sapiens	123-126
1977268-3	1990	One of the sisters experienced a common cold before the pemphigus developed and displayed a positive macrophage migration inhibition (MIF) test to a combination drug compounded of paracetamol, caffeine, chlorpheniramine maleate and phenylephrine HCl, which she had received 2 weeks prior to the appearance of the cutaneous lesions.	Caffeine	193-201	macrophage migration inhibitory factor	Homo sapiens	134-137
2344008-0	1990	The Rett syndrome related to fragile X(P22) in caffeine-induced lymphocyte culture.	Caffeine	47-55	calcineurin like EF-hand protein 1	Homo sapiens	29-42
2344008-1	1990	Chromosome analyses of lymphocytes cultured in a medium supplemented with caffeine showed a significantly higher frequency of fragile X(p22) in 13 girls with the Rett syndrome (RS) than in 9 healthy controls (p less than 0.05).	Caffeine	74-82	calcineurin like EF-hand protein 1	Homo sapiens	136-139
2299585-9	1990	The most likely mechanisms for the effects observed are 1) inhibition of acetaminophen reactive metabolite formation in 3-methylcholanthrene-induced animals by each of the methylxanthines, and 2) activation of the phenobarbital-inducible forms of cytochrome(s) P-450 toward formation of acetaminophen reactive metabolites by caffeine and theophylline, but not theobromine.	Caffeine	325-333	VPS52 subunit of GARP complex	Rattus norvegicus	52-57
2139420-9	1990	Inhibitors of ADPRT, nicotinamide, caffeine and benzamide inhibited the induction of ODC by PHA in a concentration-dependent manner, in the range (0.6-10 mM) known to inhibit ADPRT.	Caffeine	35-43	ornithine decarboxylase 1	Homo sapiens	85-88
2139420-9	1990	Inhibitors of ADPRT, nicotinamide, caffeine and benzamide inhibited the induction of ODC by PHA in a concentration-dependent manner, in the range (0.6-10 mM) known to inhibit ADPRT.	Caffeine	35-43	poly(ADP-ribose) polymerase 1	Homo sapiens	175-180
2220168-1	1990	Caffeine is mainly metabolized by 3-methyl-cholanthrene-inducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by phenobarbital inducible cytochromes P-450.	Caffeine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-82
2128110-0	1990	Influence of caffeine on the induction of SOS functions recA and umuC by mitomycin C in Escherichia coli.	Caffeine	13-21	DNA polymerase V subunit UmuC	Escherichia coli	65-69
2128110-1	1990	Caffeine alone induced the SOS functions recA and umuC in wild type recA-lacZ and umuC-lacZ fusion systems in Escherichia coli strains.	Caffeine	0-8	DNA polymerase V subunit UmuC	Escherichia coli	50-54
2128110-1	1990	Caffeine alone induced the SOS functions recA and umuC in wild type recA-lacZ and umuC-lacZ fusion systems in Escherichia coli strains.	Caffeine	0-8	DNA polymerase V subunit UmuC	Escherichia coli	82-86
2128110-2	1990	Caffeine was also able to induce umuC in a umuC-lacZ fusion strain defective in excision repair.	Caffeine	0-8	DNA polymerase V subunit UmuC	Escherichia coli	33-37
2128110-2	1990	Caffeine was also able to induce umuC in a umuC-lacZ fusion strain defective in excision repair.	Caffeine	0-8	DNA polymerase V subunit UmuC	Escherichia coli	43-47
2128110-5	1990	Cell growth in the presence of both caffeine (2 mg/ml) and MMC (0.05, 0.1 and 0.5 microgram/ml) resulted in primarily an additive induction of recA and umuC.	Caffeine	36-44	DNA polymerase V subunit UmuC	Escherichia coli	152-156
2304627-2	1990	The response to caffeine declined on repetition, but was restored completely after readmission of Ca2+.	Caffeine	16-24	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	98-101
2304627-3	1990	These results indicate that extracellular Na+ inhibits caffeine from stimulating catecholamine secretion, which may be mediated by a release of Ca2+ from intracellular storage sites in the adrenal chromaffin cells in the presence of extracellular Ca2+ and/or Mg2+.	Caffeine	55-63	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	144-147
2304627-3	1990	These results indicate that extracellular Na+ inhibits caffeine from stimulating catecholamine secretion, which may be mediated by a release of Ca2+ from intracellular storage sites in the adrenal chromaffin cells in the presence of extracellular Ca2+ and/or Mg2+.	Caffeine	55-63	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	247-250
1972997-0	1990	Central effects of corticotropin releasing factor (CRF): evidence for similar interactions with environmental novelty and with caffeine.	Caffeine	127-135	corticotropin releasing hormone	Rattus norvegicus	19-49
1972997-5	1990	Furthermore, caffeine appears to substitute for novelty in determining the direction of the locomotor effect of rCRF.	Caffeine	13-21	corticotropin releasing hormone	Rattus norvegicus	112-116
1972997-6	1990	Animals made hyperactive by caffeine show decreased activity when co-administered rCRF.	Caffeine	28-36	corticotropin releasing hormone	Rattus norvegicus	82-86
2220168-2	1990	Therefore the elimination of caffeine from serum and the amount of the main metabolites of metamizol excreted into urine reflect the activity of these two cytochrome P-450 families.	Caffeine	29-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	155-171
33973916-8	2021	In general, body metrics (body mass index) or nutritional factors (serum vitamin D, glucose levels, and caffeine intake) were found to be associated with refractive error or myopia status; however, increased insulin levels were related to increased odds of having myopia.	Caffeine	104-112	insulin	Homo sapiens	208-215
33971260-0	2021	Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	18-47
33971260-3	2021	In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response.	Caffeine	27-35	ATM serine/threonine kinase	Homo sapiens	122-151
33971260-3	2021	In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response.	Caffeine	27-35	ATM serine/threonine kinase	Homo sapiens	153-156
33971260-8	2021	Caffeine markedly exacerbated acetaminophen toxicity by suppressing ATM activity in otherwise nontoxic 2.5 millimolar amount.	Caffeine	0-8	ATM serine/threonine kinase	Homo sapiens	68-71
33971260-12	2021	The antioxidant, N-acetylcysteine, decreased oxidative damage, mitochondrial dysfunction and ATM pathway disruption to mitigate caffeine and acetaminophen toxicity.	Caffeine	128-136	ATM serine/threonine kinase	Homo sapiens	93-96
33814004-0	2021	Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF.	Caffeine	20-28	brain derived neurotrophic factor	Mus musculus	110-114
33814004-1	2021	Objective: Caffeine (CAF) is one of the most commonly consumed nutritional stimulant in beverages.	Caffeine	11-19	caffeine susceptibility	Mus musculus	21-24
33818252-3	2021	Mirroring this behavioural change, chronic caffeine treatment evidently decreased the maximal cross-sectional area and height of the longitudinal axis of fungiform taste buds, the number of taste cells per fungiform taste bud, and the expression of G protein alpha-gustducin, while the expression of the sweet taste receptors T1R2 and T1R3 was reversed.	Caffeine	43-51	taste receptor, type 1, member 2	Mus musculus	326-330
33818252-3	2021	Mirroring this behavioural change, chronic caffeine treatment evidently decreased the maximal cross-sectional area and height of the longitudinal axis of fungiform taste buds, the number of taste cells per fungiform taste bud, and the expression of G protein alpha-gustducin, while the expression of the sweet taste receptors T1R2 and T1R3 was reversed.	Caffeine	43-51	taste receptor, type 1, member 3	Mus musculus	335-339
33790369-7	2021	Concomitantly, caffeine induced a key enzyme converting KYN into KYNA, namely kynurenine aminotransferase-1 (KAT1), in murine skeletal muscle.	Caffeine	15-23	kynurenine aminotransferase 1	Mus musculus	78-107
33790369-7	2021	Concomitantly, caffeine induced a key enzyme converting KYN into KYNA, namely kynurenine aminotransferase-1 (KAT1), in murine skeletal muscle.	Caffeine	15-23	kynurenine aminotransferase 1	Mus musculus	109-113
33790369-8	2021	Upon caffeine stimulation murine myotubes exhibited KAT1 induction and its upstream PGC-1alpha sustainment.	Caffeine	5-13	kynurenine aminotransferase 1	Mus musculus	52-56
33790369-8	2021	Upon caffeine stimulation murine myotubes exhibited KAT1 induction and its upstream PGC-1alpha sustainment.	Caffeine	5-13	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	84-94
33790369-9	2021	Furthermore, a proteasome inhibitor, but not translational inhibitor, impeded caffeine sustainment of PGC-1alpha, suggesting that caffeine induced KAT1 by inhibiting proteasomal degradation of PGC-1alpha.	Caffeine	78-86	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	102-112
33790369-9	2021	Furthermore, a proteasome inhibitor, but not translational inhibitor, impeded caffeine sustainment of PGC-1alpha, suggesting that caffeine induced KAT1 by inhibiting proteasomal degradation of PGC-1alpha.	Caffeine	130-138	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	102-112
33790369-9	2021	Furthermore, a proteasome inhibitor, but not translational inhibitor, impeded caffeine sustainment of PGC-1alpha, suggesting that caffeine induced KAT1 by inhibiting proteasomal degradation of PGC-1alpha.	Caffeine	130-138	kynurenine aminotransferase 1	Mus musculus	147-151
33790369-9	2021	Furthermore, a proteasome inhibitor, but not translational inhibitor, impeded caffeine sustainment of PGC-1alpha, suggesting that caffeine induced KAT1 by inhibiting proteasomal degradation of PGC-1alpha.	Caffeine	130-138	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	193-203
33790369-10	2021	Thus, caffeine protection against CMS-induced depression may be associated with sustainment of PGC-1alpha levels and the resultant KAT1 induction in skeletal muscle, and thereby consumption of pro-neurotoxic KYN.	Caffeine	6-14	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	95-105
33790369-10	2021	Thus, caffeine protection against CMS-induced depression may be associated with sustainment of PGC-1alpha levels and the resultant KAT1 induction in skeletal muscle, and thereby consumption of pro-neurotoxic KYN.	Caffeine	6-14	kynurenine aminotransferase 1	Mus musculus	131-135
7944826-3	1994	Slice superfusion with 0.5-1 microM L-PIA or 50-100 microM caffeine plus 1 microM NMDA inhibited or potentiated, respectively, the CA1 epileptiform bursting duration with respect to a slice superfusion with 1 microM NMDA alone.	Caffeine	59-67	carbonic anhydrase 1	Rattus norvegicus	131-134
33782967-9	2021	By calcium imaging, in the absence of external calcium, TRPV1-specific opener increased intracellular calcium; this increase was abolished by preincubation with caffeine, which could deplete SR calcium store.	Caffeine	161-169	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
33764424-7	2021	Caffeine metabolism defined as fast or slow using genotype information from the single nucleotide variant rs762551 (CYP1A2*1F).	Caffeine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	116-122
33033363-0	2020	Caffeine inhibits Notum activity by binding at the catalytic pocket.	Caffeine	0-8	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	18-23
33033363-3	2020	Here we report Notum activity can be inhibited by caffeine (IC50 19 microM), but not by demethylated caffeine metabolites: paraxanthine, theobromine and theophylline.	Caffeine	50-58	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	15-20
33033363-4	2020	Cellular luciferase assays show Notum-suppressed Wnt3a function can be restored by caffeine with an EC50 of 46 microM.	Caffeine	83-91	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	32-37
33033363-4	2020	Cellular luciferase assays show Notum-suppressed Wnt3a function can be restored by caffeine with an EC50 of 46 microM.	Caffeine	83-91	Wnt family member 3A	Homo sapiens	49-54
33033363-5	2020	The dissociation constant (Kd) between Notum and caffeine is 85 microM as measured by surface plasmon resonance.	Caffeine	49-57	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	39-44
33033363-6	2020	High-resolution crystal structures of Notum complexes with caffeine and its minor metabolite theophylline show both compounds bind at the centre of the enzymatic pocket, overlapping the position of the natural substrate palmitoleic lipid, but using different binding modes.	Caffeine	59-67	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	38-43
17498734-11	2007	Importantly, both (i) 20 microM ruthenium red, a selective inhibitor of SR Ca2+ -release, and (ii) depleting SR by application of 10 microM ryanodine+1 mM caffeine, abolished the activation of IK1 by CN.	Caffeine	155-163	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	193-196
34078115-6	2022	IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine).	Caffeine	202-210	interleukin 6	Homo sapiens	0-4
34078115-4	2022	DATA SYNTHESIS: Exogenous interferons suppress CYP1A2 (theophylline, caffeine, antipyrone) clearance by 20% to 49% in patients; have minimal impact on CYP3A4 (midazolam and dapsone), CYP2C9 (tolbutamide), or CYP2C19 (mephenytoin) metabolism; and increase CYP2D6 (debrisoquine, dextromethorphan) metabolism.	Caffeine	69-77	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
34078115-6	2022	IL-6 inhibitors (sirukumab, tocilizumab, sarilumab) significantly enhance metabolism via CYP2C9 (s-warfarin), CYP2C19 (omeprazole), and CYP3A4 (simvastatin, midazolam) and reduce metabolism via CYP1A2 (caffeine).	Caffeine	202-210	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	194-200
34564828-10	2022	Correlation between DVR and serum concentration of caffeine (a nonselective A2AR blocker) was analyzed by Pearson"s correlation analysis.	Caffeine	51-59	adenosine A2a receptor	Homo sapiens	76-80
34455637-4	2022	We identified two dominant networks of interactions that mediate communication between the Ca2+ binding site and pore region in Ca2+ bound-closed state, which partially overlapped with the pore communications in ATP/CFF bound-closed RyR1 state.	Caffeine	216-219	ryanodine receptor 1	Homo sapiens	233-237
34564828-17	2022	Despite low serum caffeine levels, significant concentration-dependent effects on (11C)PLN binding to target regions were observed (p < 0.01).	Caffeine	18-26	phospholamban	Homo sapiens	87-90
34564828-18	2022	CONCLUSIONS: In this study, moderate test-retest reproducibility and large inter-subject differences were observed with (11C)PLN PET, possibly attributable to competition by baseline amount of caffeine.	Caffeine	193-201	phospholamban	Homo sapiens	125-128
34478049-0	2022	Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis.	Caffeine	0-8	NLR family, pyrin domain containing 3	Mus musculus	36-41
34478049-9	2022	Furthermore, caffeine increased the LC3-II/LC3-I levels and decreased the NLRP3 and P62 levels in EAE mice, whereas the autophagy inhibitor 3-methylamine (3-MA) blocked these effects.	Caffeine	13-21	NLR family, pyrin domain containing 3	Mus musculus	74-79
34478049-9	2022	Furthermore, caffeine increased the LC3-II/LC3-I levels and decreased the NLRP3 and P62 levels in EAE mice, whereas the autophagy inhibitor 3-methylamine (3-MA) blocked these effects.	Caffeine	13-21	nucleoporin 62	Mus musculus	84-87
34478049-10	2022	In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome.	Caffeine	10-18	mechanistic target of rapamycin kinase	Mus musculus	57-88
34478049-10	2022	In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome.	Caffeine	10-18	mechanistic target of rapamycin kinase	Mus musculus	90-94
34478049-10	2022	In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome.	Caffeine	10-18	NLR family, pyrin domain containing 3	Mus musculus	136-141
34478049-11	2022	However, autophagy-related gene 5 (ATG5)-specific siRNA abolished the anti-inflammatory effect of caffeine treatment in PM and BV2 cells.	Caffeine	98-106	autophagy related 5	Mus musculus	9-33
34478049-11	2022	However, autophagy-related gene 5 (ATG5)-specific siRNA abolished the anti-inflammatory effect of caffeine treatment in PM and BV2 cells.	Caffeine	98-106	autophagy related 5	Mus musculus	35-39
34478049-12	2022	Taken together, these data suggest that caffeine exerts a newly discovered effect on EAE by reducing NLRP3 inflammasome activation via the induction of autophagy in microglia.	Caffeine	40-48	NLR family, pyrin domain containing 3	Mus musculus	101-106
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	0-8	antigen identified by monoclonal antibody Ki 67	Mus musculus	178-182
34969831-4	2022	To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect.	Caffeine	175-183	acetylcholinesterase (Cartwright blood group)	Homo sapiens	210-214
34969831-9	2022	Thus, the new synthetized compounds can inhibit the AChE and activate muscle and alpha7 nAChRs with greater potency than caffeine, which suggests that they could be useful leaders for the development of new therapies for the treatment of different neurological diseases.	Caffeine	121-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
34969831-10	2022	Significance Statement In this work we synthetized caffeine derivatives which can inhibit the AChE and activate both muscle and alpha7 nAChRs with higher potency than caffeine.	Caffeine	51-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
34969831-10	2022	Significance Statement In this work we synthetized caffeine derivatives which can inhibit the AChE and activate both muscle and alpha7 nAChRs with higher potency than caffeine.	Caffeine	167-175	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
34564706-2	2022	Herein, we addressed the novel hypothesis that genetic variation in CYP1A2, a gene responsible for more than 95% of caffeine metabolism, differentially impacts the association of coffee consumption with appetite and BMI among individuals with different genetic predispositions to obesity.	Caffeine	116-124	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74
34564706-5	2022	Participants were stratified according to a validated genetic risk score (GRS) for obesity and to the -163C > A (rs762551) polymorphism of CYP1A2 as rapid (AA), intermediate (AC), or slow (CC) caffeine metabolizers.	Caffeine	193-201	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	139-145
34969831-3	2022	Given that caffeine is a natural compound that behaves as an AChE inhibitor and as a partial agonist of nAChRs, the aim of this work was to synthetize more potent bifunctional caffeine analogs that modulate these two molecular targets.	Caffeine	11-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
34969831-3	2022	Given that caffeine is a natural compound that behaves as an AChE inhibitor and as a partial agonist of nAChRs, the aim of this work was to synthetize more potent bifunctional caffeine analogs that modulate these two molecular targets.	Caffeine	176-184	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	0-8	mitogen-activated protein kinase 3	Mus musculus	187-193
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	0-8	transformation related protein 53, pseudogene	Mus musculus	225-228
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	161-169	antigen identified by monoclonal antibody Ki 67	Mus musculus	178-182
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	161-169	mitogen-activated protein kinase 3	Mus musculus	187-193
34979447-7	2021	Caffeine potentiated dacarbazine-induced cytotoxic effects by increasing dacarbazine biotransformation, apoptosis, DNA damage, and malondialdehyde levels; also, caffeine reduced Ki67 and ERK1/2 nuclear labeling and increased p53 labeling in B16F10 cells.	Caffeine	161-169	transformation related protein 53, pseudogene	Mus musculus	225-228
34946741-0	2021	Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin alphav, beta3, and FAK/Akt/c-Myc Signaling Pathway.	Caffeine	0-8	integrin subunit alpha V	Homo sapiens	72-94
34946741-0	2021	Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin alphav, beta3, and FAK/Akt/c-Myc Signaling Pathway.	Caffeine	0-8	protein tyrosine kinase 2	Homo sapiens	100-103
34946741-0	2021	Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin alphav, beta3, and FAK/Akt/c-Myc Signaling Pathway.	Caffeine	0-8	AKT serine/threonine kinase 1	Homo sapiens	104-107
34946741-0	2021	Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin alphav, beta3, and FAK/Akt/c-Myc Signaling Pathway.	Caffeine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
34946741-8	2021	Subsequently, the downstream signals, including protein signaling and transcription factors, namely, phosphorylated focal adhesion kinase (p-FAK), phosphorylated protein kinase B (p-Akt), cell division cycle 42 (Cdc42), and c-Myc, were significantly decreased in caffeine-exposed cells.	Caffeine	263-271	protein tyrosine kinase 2 beta	Homo sapiens	162-178
34946741-8	2021	Subsequently, the downstream signals, including protein signaling and transcription factors, namely, phosphorylated focal adhesion kinase (p-FAK), phosphorylated protein kinase B (p-Akt), cell division cycle 42 (Cdc42), and c-Myc, were significantly decreased in caffeine-exposed cells.	Caffeine	263-271	AKT serine/threonine kinase 1	Homo sapiens	182-185
34946741-8	2021	Subsequently, the downstream signals, including protein signaling and transcription factors, namely, phosphorylated focal adhesion kinase (p-FAK), phosphorylated protein kinase B (p-Akt), cell division cycle 42 (Cdc42), and c-Myc, were significantly decreased in caffeine-exposed cells.	Caffeine	263-271	cell division cycle 42	Homo sapiens	212-217
34946741-8	2021	Subsequently, the downstream signals, including protein signaling and transcription factors, namely, phosphorylated focal adhesion kinase (p-FAK), phosphorylated protein kinase B (p-Akt), cell division cycle 42 (Cdc42), and c-Myc, were significantly decreased in caffeine-exposed cells.	Caffeine	263-271	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	224-229
34946538-6	2021	Similar to the caffeine, significant elevation of interferon-gamma and tumor necrosis factor-alpha was observed in the serum and tumor tissues of rats after the theacrine supplement of 50 mg/kg body weight.	Caffeine	15-23	interferon gamma	Rattus norvegicus	50-98
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	tumor necrosis factor	Mus musculus	25-52
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	tumor necrosis factor	Mus musculus	54-63
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	interleukin 1 beta	Mus musculus	66-83
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	interleukin 1 alpha	Mus musculus	85-93
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	interleukin 6	Mus musculus	96-100
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	nitric oxide synthase 2, inducible	Mus musculus	106-137
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	nitric oxide synthase 2, inducible	Mus musculus	139-143
34948033-8	2021	It was found that acute administration of CAF suppressed the synthesis of interleukin (IL-1beta) and tumor necrosis factor (TNF)alpha, but did not influence IL-6, in the hypothalamus during LPS-induced inflammation.	Caffeine	42-45	interleukin-1 alpha	Ovis aries	87-95
34876109-7	2021	In vitro, primary human trophoblasts and BeWo cells were used to confirm the effect of caffeine on P-gp and its mechanism.	Caffeine	87-95	phosphoglycolate phosphatase	Homo sapiens	99-103
34876109-10	2021	Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development.	Caffeine	55-63	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	175-179
34876109-10	2021	Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development.	Caffeine	114-122	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	175-179
34876109-10	2021	Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development.	Caffeine	114-122	ryanodine receptor 2	Rattus norvegicus	184-187
34876109-10	2021	Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development.	Caffeine	114-122	mitogen-activated protein kinase 8	Rattus norvegicus	188-191
34876109-10	2021	Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development.	Caffeine	114-122	Y box binding protein 1	Rattus norvegicus	192-196
34876109-11	2021	We further demonstrated that P-gp inducer sodium ferulate could reverse the inhibitory effect of caffeine on the fetal body/placental weight.	Caffeine	97-105	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	29-33
34948033-9	2021	The injection of CAF reduced the LPS-induced expression of TNF mRNA in the ChP.	Caffeine	17-20	tumor necrosis factor	Ovis aries	59-62
34948033-10	2021	CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP.	Caffeine	0-3	interleukin-6	Ovis aries	35-39
34948033-8	2021	It was found that acute administration of CAF suppressed the synthesis of interleukin (IL-1beta) and tumor necrosis factor (TNF)alpha, but did not influence IL-6, in the hypothalamus during LPS-induced inflammation.	Caffeine	42-45	tumor necrosis factor	Ovis aries	101-122
34948033-8	2021	It was found that acute administration of CAF suppressed the synthesis of interleukin (IL-1beta) and tumor necrosis factor (TNF)alpha, but did not influence IL-6, in the hypothalamus during LPS-induced inflammation.	Caffeine	42-45	tumor necrosis factor	Ovis aries	124-133
34788016-6	2021	Nanomolar tetrabromopyrrole (TBP, 1) potentiated caffeine-triggered Ca2+ release independent of extracellular (Ca2+) in RYR1-HEK293, whereas higher concentrations produce slow and sustained rise in cytoplasmic (Ca2+) independent of RYR1 expression.	Caffeine	49-57	proteasome (prosome, macropain) 26S subunit, ATPase 3	Mus musculus	29-35
34948033-10	2021	CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP.	Caffeine	0-3	interleukin-6 receptor subunit beta	Ovis aries	75-80
34948033-10	2021	CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP.	Caffeine	0-3	tumor necrosis factor receptor superfamily member 1A	Ovis aries	86-120
34948033-10	2021	CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP.	Caffeine	0-3	tumor necrosis factor receptor superfamily member 1A	Ovis aries	122-129
34948033-10	2021	CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP.	Caffeine	0-3	interleukin-1 receptor type 2	Ovis aries	178-183
34950703-9	2021	cADPR is a ryanodine receptor (RyR) agonist and like caffeine, which also activates the RyR, both mimicked the effects of NAD+.	Caffeine	53-61	ryanodine receptor 2	Homo sapiens	11-29
34950703-9	2021	cADPR is a ryanodine receptor (RyR) agonist and like caffeine, which also activates the RyR, both mimicked the effects of NAD+.	Caffeine	53-61	ryanodine receptor 2	Homo sapiens	88-91
34950703-11	2021	The observation that NAD+, cADPR, and caffeine all attenuated the increase in O-GlcNAc and ER stress in response to glucose deprivation, suggests a potential common mechanism, linked to ER/SR Ca2+ levels, underlying their activation.	Caffeine	38-46	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	78-86
34529114-7	2021	One significant caffeine-gene interaction was observed for CYP1A2 (rs762551, p = 0.004) on average power.	Caffeine	16-24	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-65
34817846-8	2022	NARON ACE contains bromvalerylurea, ibuprofen, ethenzamide, and anhydrous caffeine; only the amount of bromvalerylurea was thought to exceed a lethal dose.	Caffeine	74-82	angiotensin I converting enzyme	Homo sapiens	6-9
34637050-10	2021	The current data support that caffeine regulates GAT-1 function and improves striatal GABA transport via A1R-cAMP-PKA signaling, specifically in SHR.	Caffeine	30-38	solute carrier family 6 member 1	Rattus norvegicus	49-54
34363706-11	2021	The molecular analysis indicated higher expression of bone formation (ALP), remodeling (CatK), and vascularization (VEGF) genes in implant-adherent cells in the CAF group.	Caffeine	161-164	PDZ and LIM domain 3	Rattus norvegicus	70-73
34363706-11	2021	The molecular analysis indicated higher expression of bone formation (ALP), remodeling (CatK), and vascularization (VEGF) genes in implant-adherent cells in the CAF group.	Caffeine	161-164	vascular endothelial growth factor A	Rattus norvegicus	116-120
34869338-0	2021	Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1alpha Pathway.	Caffeine	0-8	serum/glucocorticoid regulated kinase 1	Homo sapiens	72-76
34927011-3	2021	Here, we identify xanthines including caffeine and istradefylline as TLX modulators that counteract the receptor"s intrinsic repressor activity.	Caffeine	38-46	CD46 molecule	Homo sapiens	69-72
34806929-5	2021	Results showed caffeine had no effect on alpha asymmetry in the SZ group, although caffeine produced a more global effect on the reduction of alpha2 power in the SZ group.	Caffeine	83-91	glycoprotein hormone subunit alpha 2	Homo sapiens	142-148
34806929-6	2021	Further, those with more positive symptoms were found to have a greater reduction in alpha2 power following caffeine administration.	Caffeine	108-116	glycoprotein hormone subunit alpha 2	Homo sapiens	85-91
34869338-0	2021	Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1alpha Pathway.	Caffeine	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
34869338-11	2021	The results of flow cytometry, TUNEL assay, immunocytochemistry, qRT-PCR, and Western blotting showed that caffeine caused autophagy and apoptosis via SGK1 pathway.	Caffeine	107-115	serum/glucocorticoid regulated kinase 1	Homo sapiens	151-155
34869338-15	2021	Together, these results indicated that caffeine induces autophagy and apoptosis in auditory hair cells via the SGK1/HIF-1alpha pathway, suggesting that caffeine may cause hearing loss.	Caffeine	39-47	serum/glucocorticoid regulated kinase 1	Homo sapiens	111-115
34869338-15	2021	Together, these results indicated that caffeine induces autophagy and apoptosis in auditory hair cells via the SGK1/HIF-1alpha pathway, suggesting that caffeine may cause hearing loss.	Caffeine	39-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
34869338-15	2021	Together, these results indicated that caffeine induces autophagy and apoptosis in auditory hair cells via the SGK1/HIF-1alpha pathway, suggesting that caffeine may cause hearing loss.	Caffeine	152-160	serum/glucocorticoid regulated kinase 1	Homo sapiens	111-115
34869338-15	2021	Together, these results indicated that caffeine induces autophagy and apoptosis in auditory hair cells via the SGK1/HIF-1alpha pathway, suggesting that caffeine may cause hearing loss.	Caffeine	152-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
34697258-0	2022	Comment on "CYP1A2 Genotype Modifies the Effects of Caffeine Compared With Placebo on Muscle Strength in Competitive Male Athletes".	Caffeine	52-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
34352284-5	2021	The root mean square error of prediction (RMSEP) for the PLS1 model for single API caffeine tablets using TRS and NIR HSI was 0.27% and 0.36% respectively.	Caffeine	83-91	plastin 1	Homo sapiens	57-61
34352284-6	2021	The RMSEP for the PLS1 models built using TRS for the double API tablets was 0.29% for API A and 0.34% for caffeine.	Caffeine	107-115	plastin 1	Homo sapiens	18-22
34364467-0	2021	The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS.	Caffeine	38-46	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	82-88
34465058-0	2021	H19/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance.	Caffeine	24-32	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	0-3
34605007-8	2022	GSK-evoked Ca2+ waves, when mitochondria were depolarised, were blocked by the TRPV4 channel blocker HC067047, the SERCA inhibitor cyclopiazonic acid, the phospholipase C (PLC) blocker U73122 and the inositol triphosphate receptor (IP3 R) blocker caffeine.	Caffeine	247-255	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	232-237
34648073-4	2021	In control cardiomyocytes, we enhanced RyR leak (by low (caffeine) plus isoproterenol mimicking CPVT) which markedly increased STV and delayed afterdepolarizations (DADs).	Caffeine	57-65	ryanodine receptor 2	Homo sapiens	39-42
34352333-6	2021	However, variability was quite limited for CYP1A2, using caffeine as a probe substrate, with a symmetrical distribution of metabolic activity values.	Caffeine	57-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-49
34622282-9	2022	Finally, caffeine was shown to rescue aberrant motor function in C. elegans harboring the goa-1 variants; this effect is mainly exerted through adenosine receptor antagonism.	Caffeine	9-17	Guanine nucleotide-binding protein G(o) subunit alpha	Caenorhabditis elegans	90-95
34611052-0	2022	CYP1A2 Genotype Polymorphism Influences the Effect of Caffeine on Anaerobic Performance in Trained Males.	Caffeine	54-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
34611052-1	2022	The purpose was to investigate the effects of CYP1A2 -163C > A polymorphism on the effects of acute caffeine (CAF) supplementation on anaerobic power in trained males.	Caffeine	110-113	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-52
34937961-0	2021	The prevalence and practices of caffeine use as an ergogenic aid in English professional soccer.	Caffeine	32-40	activation induced cytidine deaminase	Homo sapiens	61-64
34448639-6	2021	Contractility and Ca2+ transients (Fura 2-AM) in cardiomyocytes from MI-treated TG-alpha2 animals showed reduced Ca2+ amplitudes during pacing or after caffeine application.	Caffeine	152-160	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	83-89
34602096-1	2021	BACKGROUND: Caffeine (0.1 g) is used as a central nervous system stimulant and as a nontoxic phenotyping probe for cytochrome P450 1A2.	Caffeine	12-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	115-134
34391636-5	2021	RESULTS: Three nutrient principal components (PC) were identified: PC1 (high caffeine and saccharin intake), PC2 (high alcohol and caffeine, lower intake of essential nutrients) and PC3 (higher fiber/micronutrients, low alcohol).	Caffeine	77-85	proprotein convertase subtilisin/kexin type 1	Homo sapiens	67-70
34310936-4	2021	Caffeine, an adenosine A1 receptors and A2AR antagonist, and other A2AR antagonists were reported to improve olfactory function and restore age-related olfactory deficits.	Caffeine	0-8	adenosine A2a receptor	Mus musculus	40-44
34563696-1	2021	PURPOSE: To determine whether prophylactic caffeine and ibuprofen, which have been shown to have vascular endothelial growth factor-modulating properties in other contexts, have a detectable effect on the incidence of severe retinopathy of prematurity (ROP) when administered in extremely low birth weight infants during the first 48 hours of life.	Caffeine	43-51	vascular endothelial growth factor A	Homo sapiens	97-131
34590332-0	2022	Caffeine-induced neurotoxicity mediated by Nrf2 pathway in PC12 cells and zebrafish larvae.	Caffeine	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
34543976-3	2021	The elimination of two model PPCPs, primidone (PRM) and caffeine (CAF), by the co-exposure of UV and free chlorine was investigated to elucidate the impact of EfOM.	Caffeine	56-64	lysine acetyltransferase 2B	Homo sapiens	66-69
34590332-7	2022	Quantitative polymerase chain reaction (qPCR) and western blotting revealed that caffeine also inhibited the expression levels of Nrf2 mRNA and protein and its target genes (e.g., NADPH quinone oxidoreductase 1 (NQO1)).	Caffeine	81-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
34590332-7	2022	Quantitative polymerase chain reaction (qPCR) and western blotting revealed that caffeine also inhibited the expression levels of Nrf2 mRNA and protein and its target genes (e.g., NADPH quinone oxidoreductase 1 (NQO1)).	Caffeine	81-89	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	180-210
34590332-7	2022	Quantitative polymerase chain reaction (qPCR) and western blotting revealed that caffeine also inhibited the expression levels of Nrf2 mRNA and protein and its target genes (e.g., NADPH quinone oxidoreductase 1 (NQO1)).	Caffeine	81-89	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	212-216
34590332-8	2022	Furthermore, Nrf2 silencing attenuated the toxic effects of caffeine.	Caffeine	60-68	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
34590332-12	2022	Finally, qPCR revealed that a higher dose of caffeine inhibited mRNA levels in the Nrf2 pathway.	Caffeine	45-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
34590332-13	2022	Based on these results, this study identified for the first time that overuse of caffeine can induce neurotoxicity by inhibiting the Nrf2 pathway.	Caffeine	81-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	133-137
34565388-1	2021	BACKGROUND: Carbohydrate (CHO) and caffeine (CAF) mouth rinsing have been shown to enhance endurance and sprint performance.	Caffeine	35-43	lysine acetyltransferase 2B	Homo sapiens	45-48
34246192-0	2021	Caffeine prevents oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor.	Caffeine	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
34538097-2	2022	While some in vitro studies show a caffeine-induced decrease in vitamin D receptor expression, there is a paucity of research to define the extent of caffeine intake on 25(OH)D levels.	Caffeine	35-43	vitamin D receptor	Homo sapiens	64-82
34527815-2	2021	There are natural herbal supplements containing rutaecarpine that are designed to enhance the CYP1A2-dependent removal of caffeine from blood so that people can have coffee later in the day without causing sleep interference.	Caffeine	122-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	94-100
34578966-0	2021	Caffeine as a Factor Influencing the Functioning of the Human Body-Friend or Foe?	Caffeine	0-8	WAPL cohesin release factor	Homo sapiens	77-80
34246192-0	2021	Caffeine prevents oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor.	Caffeine	0-8	snail family transcriptional repressor 1	Homo sapiens	178-184
34246192-10	2021	Finally, silencing of Nrf2 expression by small interfering RNA (siRNA) could abolish such protective effects of caffeine on oxalate-induced EMT.	Caffeine	112-120	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
34246192-11	2021	Our data indicate that the renoprotective effects of caffeine against oxalate-induced EMT is mediated, at least in part, by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor.	Caffeine	53-61	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
34246192-11	2021	Our data indicate that the renoprotective effects of caffeine against oxalate-induced EMT is mediated, at least in part, by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor.	Caffeine	53-61	snail family transcriptional repressor 1	Homo sapiens	208-214
34352272-0	2021	Structural and functional interactions between the Ca2+, ATP, and caffeine binding sites of skeletal muscle ryanodine receptor (RyR1).	Caffeine	66-74	ryanodine receptor 1	Homo sapiens	92-126
34352272-10	2021	In the presence of ATP and caffeine but absence of Ca2+, Na+ is predicted to inhibit RyR1 by interacting with the Ca2+ binding site.	Caffeine	27-35	ryanodine receptor 1	Homo sapiens	85-89
34352272-12	2021	We conclude that Ca2+, ATP, and caffeine regulate RyR1 through a network of allosteric interactions involving the Ca2+, ATP, and caffeine binding sites.	Caffeine	32-40	ryanodine receptor 1	Homo sapiens	50-54
34352272-0	2021	Structural and functional interactions between the Ca2+, ATP, and caffeine binding sites of skeletal muscle ryanodine receptor (RyR1).	Caffeine	66-74	ryanodine receptor 1	Homo sapiens	128-132
34352272-12	2021	We conclude that Ca2+, ATP, and caffeine regulate RyR1 through a network of allosteric interactions involving the Ca2+, ATP, and caffeine binding sites.	Caffeine	129-137	ryanodine receptor 1	Homo sapiens	50-54
34352272-2	2021	Multiple endogenous and exogenous effectors regulate RyR1, such as ATP, Ca2+, caffeine, and ryanodine.	Caffeine	78-86	ryanodine receptor 1	Homo sapiens	53-57
34352272-5	2021	Here we used (3H)ryanodine ligand binding assays and molecular dynamics simulations to test the hypothesis that both the ATP and caffeine binding sites communicate with the Ca2+ binding site to sensitize RyR1 to Ca2+.	Caffeine	129-137	ryanodine receptor 1	Homo sapiens	204-208
34352272-6	2021	We report that either AMPPCP, a nonhydrolyzable ATP analog, or caffeine can activate RyR1 in the absence or presence of Ca2+.	Caffeine	63-71	ryanodine receptor 1	Homo sapiens	85-89
34352272-7	2021	However, enhanced RyR1 activation occurred in the presence of Ca2+, AMPPCP, and caffeine.	Caffeine	80-88	ryanodine receptor 1	Homo sapiens	18-22
34352272-8	2021	In the absence of Ca2+, Na+ inhibited (3H)ryanodine binding without impairing RyR1 activation by AMPPCP and caffeine.	Caffeine	108-116	ryanodine receptor 1	Homo sapiens	78-82
34352272-9	2021	Computational analysis suggested that Ca2+, ATP, and caffeine binding sites modulate RyR1 protein stability through interactions with the carboxy-terminal domain and other domains in the activation core.	Caffeine	53-61	ryanodine receptor 1	Homo sapiens	85-89
34502402-4	2021	Addition of cyclosporin A, a blocker of mitochondrial permeability transition pore (mPTP), antioxidant trolox, or inositol 1,4,5-trisphosphate receptor (IP3R) blocker caffeine in the presence of rotenone reduced the elevated rate and the amplitude of the signals implying sensitivity to reactive oxygen species (ROS), and involvement of mitochondrial mPTP together with IP3R.	Caffeine	167-175	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	153-157
34216353-1	2021	Ecto-5"-nucleotidase or CD73 is the main source of extracellular adenosine involved in the activation of adenosine A2A receptors, responsible for the ergogenic effects of caffeine.	Caffeine	171-179	5' nucleotidase, ecto	Mus musculus	0-20
34216353-1	2021	Ecto-5"-nucleotidase or CD73 is the main source of extracellular adenosine involved in the activation of adenosine A2A receptors, responsible for the ergogenic effects of caffeine.	Caffeine	171-179	5' nucleotidase, ecto	Mus musculus	24-28
34502402-4	2021	Addition of cyclosporin A, a blocker of mitochondrial permeability transition pore (mPTP), antioxidant trolox, or inositol 1,4,5-trisphosphate receptor (IP3R) blocker caffeine in the presence of rotenone reduced the elevated rate and the amplitude of the signals implying sensitivity to reactive oxygen species (ROS), and involvement of mitochondrial mPTP together with IP3R.	Caffeine	167-175	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	370-374
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Caffeine	17-25	FEV transcription factor, ETS family member	Homo sapiens	55-60
34646532-10	2021	Moreover, the main phytochemicals in the three tea extracts were determined and quantified via high-performance liquid chromatography, and the most commonly detected ingredients were catechins and caffeine, which could exert the protective effects on AFLD.	Caffeine	197-205	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	47-50
34513920-6	2021	Interestingly, iAng II was found to decrease the caffeine-induced increase in spontaneous APs and caffeine-induced calcium release, suggesting that iAng II decreased spontaneous APs via the AT2R- and ryanodine receptor-mediated pathways.	Caffeine	49-57	angiotensin II receptor, type 2	Rattus norvegicus	190-194
34391463-2	2021	Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee drinkers.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19
34391463-2	2021	Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee drinkers.	Caffeine	80-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Caffeine	17-25	FEV transcription factor, ETS family member	Homo sapiens	91-96
34532382-10	2021	Furthermore, ARS staining, ALP staining, ORO staining, and qRT-PCR assay showed that excessive caffeine induced bone loss and osteoporosis (OP) in mice by regulating the osteogenesis and adipogenesis of BMSCs.	Caffeine	95-103	secreted Ly6/Plaur domain containing 1	Mus musculus	13-16
34333892-6	2022	In the presence of caffeine, an inhibitor of the cell cycle checkpoint kinases, Cdc6 was stabilized, demonstrating that its degradation is controlled by the DNA damage cell cycle checkpoint.	Caffeine	19-27	cell division cycle 6	Homo sapiens	80-84
34532382-11	2021	Also, PL treatment could reverse the caffeine-induced dysfunctions and aberrant differentiation of BMSCs via the ER pathway.	Caffeine	37-45	estrogen receptor 1 (alpha)	Mus musculus	113-115
34454690-9	2021	SN/CAF at 3:90 muM also downregulated the expression of cell cycle control (CDKN1A) genes.	Caffeine	3-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-82
34074584-2	2021	We hypothesized that IL-10 may be responsible for the reduction in fatigue perception in response to caffeine supplementation.	Caffeine	101-109	interleukin 10	Homo sapiens	21-26
34074584-7	2021	We verify that IL-6 (0.35; 95% CI: 0.13 to 0.56; z = 3.24; p = 0.001; d = 1.14) and IL-10 (9.06; 95% CI 0.41 to 17.70; z = 2.05; p = 0.04; d = 1.12) increases post-PE in CAF group versus PLA group.	Caffeine	170-173	interleukin 6	Homo sapiens	15-19
34074584-7	2021	We verify that IL-6 (0.35; 95% CI: 0.13 to 0.56; z = 3.24; p = 0.001; d = 1.14) and IL-10 (9.06; 95% CI 0.41 to 17.70; z = 2.05; p = 0.04; d = 1.12) increases post-PE in CAF group versus PLA group.	Caffeine	170-173	interleukin 10	Homo sapiens	84-89
34074584-11	2021	IL-10 levels were higher 1 h post-PE in CAF group, suggesting, according to our hypothesis, that IL-10 may be associated with decrease fatigue perceptions after exercise.	Caffeine	40-43	interleukin 10	Homo sapiens	0-5
34074584-11	2021	IL-10 levels were higher 1 h post-PE in CAF group, suggesting, according to our hypothesis, that IL-10 may be associated with decrease fatigue perceptions after exercise.	Caffeine	40-43	interleukin 10	Homo sapiens	97-102
34187286-2	2021	Metabolic loss of 18F from PET probes in vivo can lead to misleading biodistribution data as displaced 18F can accumulate in various tissues.In this study we report on in vitro hepatic microsomal metabolism of novel caffeine containing bifunctional compounds (C8-6-I, C8-6-N, C8-6-C8) that can prevent in vitro aggregation of alpha-synuclein, which is associated with the pathophysiology of Parkinson"s disease.	Caffeine	216-224	synuclein alpha	Homo sapiens	326-341
34324416-4	2021	By contrast to caffeine, CB002-analogs target an S-phase checkpoint associated with increased p-RPA/RPA2, p-ATR, decreased Cyclin A, p-histone H3 expression, and downregulation of essential proteins in DNA-synthesis and DNA-repair.	Caffeine	15-23	replication protein A2	Homo sapiens	100-104
34324416-4	2021	By contrast to caffeine, CB002-analogs target an S-phase checkpoint associated with increased p-RPA/RPA2, p-ATR, decreased Cyclin A, p-histone H3 expression, and downregulation of essential proteins in DNA-synthesis and DNA-repair.	Caffeine	15-23	ATR serine/threonine kinase	Homo sapiens	108-111
34324416-4	2021	By contrast to caffeine, CB002-analogs target an S-phase checkpoint associated with increased p-RPA/RPA2, p-ATR, decreased Cyclin A, p-histone H3 expression, and downregulation of essential proteins in DNA-synthesis and DNA-repair.	Caffeine	15-23	cyclin A2	Homo sapiens	123-131
34291833-8	2022	However, SERT gene expression linearly increased with increasing caffeine dosage (p < 0.01).	Caffeine	65-73	solute carrier family 6 member 4	Gallus gallus	9-13
34444677-6	2021	We found that the long-term caffeine intake (10 mM) in the L4-stage worms at 25  C for 3 days suppressed ACT-5 mislocalization.	Caffeine	28-36	ACTin	Caenorhabditis elegans	105-110
34484675-10	2021	In conclusion, caffeine seems to attenuate ethanol-induced inflammation in the cerebellum of UChB rats through the A1 and A2a modulation, playing a neuroprotective role in the chronic context of ethanol consumption.	Caffeine	15-23	spectrin, alpha, non-erythrocytic 1	Rattus norvegicus	122-125
34291833-9	2022	The impact of caffeine on ADORA1 gene expression was dose dependent and nonlinear.	Caffeine	14-22	adenosine A1 receptor	Gallus gallus	26-32
34257294-4	2021	Cpd1 reduces resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, suppresses caffeine-induced contracture in skeletal muscle, reduces sarcolemmal cation influx, and prevents or reverses the fulminant MH crisis induced by isoflurane anesthesia and rescues animals from heat stroke caused by environmental heat stress.	Caffeine	109-117	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	0-4
34284351-0	2021	CYP1A2 Genotype Modifies the Effects of Caffeine Compared With Placebo on Muscle Strength in Competitive Male Athletes.	Caffeine	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
34284351-2	2021	Previously, the CYP1A2 gene has been shown to modify the effects of caffeine on endurance performance.	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-22
34371919-0	2021	Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations.	Caffeine	0-8	NLR family pyrin domain containing 3	Homo sapiens	78-83
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	tumor necrosis factor	Homo sapiens	24-33
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	interleukin 6	Homo sapiens	134-138
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	interleukin 1 alpha	Homo sapiens	144-152
34371919-7	2021	We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-MPhis.	Caffeine	15-23	AKT serine/threonine kinase 1	Homo sapiens	79-82
34371919-7	2021	We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-MPhis.	Caffeine	15-23	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	83-87
34371919-7	2021	We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-MPhis.	Caffeine	15-23	mechanistic target of rapamycin kinase	Homo sapiens	88-92
34371919-7	2021	We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-MPhis.	Caffeine	15-23	signal transducer and activator of transcription 1	Homo sapiens	131-136
34371919-7	2021	We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-MPhis.	Caffeine	15-23	interleukin 10	Homo sapiens	137-142
34371919-8	2021	We hypothesized that these alterations play an important modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1beta secretion in LPS-activated M-MPhis following caffeine treatment.	Caffeine	178-186	NLR family pyrin domain containing 3	Homo sapiens	96-101
34371919-8	2021	We hypothesized that these alterations play an important modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1beta secretion in LPS-activated M-MPhis following caffeine treatment.	Caffeine	178-186	interleukin 1 alpha	Homo sapiens	124-132
34250774-10	2021	Chlorpyrifos (100 mg/kg) alone and in combination with caffeine (40 mg/kg) significantly reduced acetylcholinesterase (AChE) activity.	Caffeine	55-63	acetylcholinesterase	Mus musculus	97-117
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	tyrosinase	Homo sapiens	0-10
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	interleukin 1 alpha	Homo sapiens	147-155
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	C-X-C motif chemokine ligand 10	Homo sapiens	157-162
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	C-C motif chemokine ligand 3	Homo sapiens	164-174
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	C-C motif chemokine ligand 3	Homo sapiens	176-185
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	C-C motif chemokine ligand 5	Homo sapiens	190-196
34199192-8	2021	These data suggest tyrosinase as a key player mediating the effects of caffeine on melanoma.	Caffeine	71-79	tyrosinase	Homo sapiens	19-29
34060393-7	2022	The caspase-3 expression of TMZ plus Caffeine group was higher significantly than that of the control group and TMZ group.	Caffeine	37-45	caspase 3	Rattus norvegicus	4-13
34274079-11	2021	Significant changes were observed in the RMSSD, SDNN, TINN, SD1, low frequency and high frequency indices between the control and CAF group.	Caffeine	130-133	CUP2Q35	Homo sapiens	60-63
34201708-8	2021	Caffeine inhibited basal and insulin-stimulated glucose transport as well as lipogenesis in rodent adipose cells.	Caffeine	0-8	insulin	Homo sapiens	29-36
34201708-11	2021	Insulin increased uptake by 3.86 +- 1.11 fold when tested alone at 100 nM, and by 3.21 +- 0.80 when combined with caffeine.	Caffeine	114-122	insulin	Homo sapiens	0-7
34250774-10	2021	Chlorpyrifos (100 mg/kg) alone and in combination with caffeine (40 mg/kg) significantly reduced acetylcholinesterase (AChE) activity.	Caffeine	55-63	acetylcholinesterase	Mus musculus	119-123
35536225-0	2022	Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation.	Caffeine	0-8	thymoma viral proto-oncogene 1	Mus musculus	21-24
34063734-1	2021	In this study, we report the effects of caffeine on angiogenesis in zebrafish embryos both during normal development and after exposure to Fibroblast Growth Factor 2 (FGF2).	Caffeine	40-48	fibroblast growth factor 2	Danio rerio	139-165
34063734-1	2021	In this study, we report the effects of caffeine on angiogenesis in zebrafish embryos both during normal development and after exposure to Fibroblast Growth Factor 2 (FGF2).	Caffeine	40-48	fibroblast growth factor 2	Danio rerio	167-171
34063734-5	2021	Caffeine was also able to block angiogenesis induced by exogenous FGF2 or FGF2-producing cells.	Caffeine	0-8	fibroblast growth factor 2	Danio rerio	66-70
34063734-5	2021	Caffeine was also able to block angiogenesis induced by exogenous FGF2 or FGF2-producing cells.	Caffeine	0-8	fibroblast growth factor 2	Danio rerio	74-78
35469867-5	2022	Moreover, the concentrations of benzotriazole (6340 ngL-1) and caffeine (3310 ngL-1) were also high.	Caffeine	63-71	leucine rich repeat containing 4C	Homo sapiens	78-83
35393758-9	2022	Caffeine alleviated the hypoxic-ischemic WMD-induced cognitive impairment and improved MBP, synaptophysin, and postsynaptic density protein 95 protein levels after hypoxic-ischemic WMD by preventing the HI-induced downregulation of SIRT2; these effects were subsequently attenuated by the SIRT2 inhibitor AK-7.	Caffeine	0-8	myelin basic protein	Rattus norvegicus	87-90
35393758-9	2022	Caffeine alleviated the hypoxic-ischemic WMD-induced cognitive impairment and improved MBP, synaptophysin, and postsynaptic density protein 95 protein levels after hypoxic-ischemic WMD by preventing the HI-induced downregulation of SIRT2; these effects were subsequently attenuated by the SIRT2 inhibitor AK-7.	Caffeine	0-8	synaptophysin	Rattus norvegicus	92-105
35393758-9	2022	Caffeine alleviated the hypoxic-ischemic WMD-induced cognitive impairment and improved MBP, synaptophysin, and postsynaptic density protein 95 protein levels after hypoxic-ischemic WMD by preventing the HI-induced downregulation of SIRT2; these effects were subsequently attenuated by the SIRT2 inhibitor AK-7.	Caffeine	0-8	discs large MAGUK scaffold protein 4	Rattus norvegicus	111-142
35393758-9	2022	Caffeine alleviated the hypoxic-ischemic WMD-induced cognitive impairment and improved MBP, synaptophysin, and postsynaptic density protein 95 protein levels after hypoxic-ischemic WMD by preventing the HI-induced downregulation of SIRT2; these effects were subsequently attenuated by the SIRT2 inhibitor AK-7.	Caffeine	0-8	adenylate kinase 7	Rattus norvegicus	305-309
34069892-7	2021	Caffeine in a dose of 3 mg/kg BM in elite Jiu-Jitsu athletes is a recommended ergogenic aid as it increased performance of bilateral and unilateral vertical jumps.	Caffeine	0-8	activation induced cytidine deaminase	Homo sapiens	88-91
35616851-2	2022	Studies have investigated the impact of caffeine intake upon EP and core temperature (CT) in the heat, but results are conflicting.	Caffeine	40-48	epiregulin	Homo sapiens	61-63
35616851-4	2022	OBJECTIVE: To use a meta-analytical approach to determine the effect of pre-exercise caffeine intake on EP and CT in the heat.	Caffeine	85-93	epiregulin	Homo sapiens	104-106
35616851-10	2022	Caffeine supplementation non-significantly improved EP by 2.1 +- 0.8% (95% CI - 0.7 to 4.8) and significantly increased the rate of change in CT by 0.10 +- 0.03  C/h (95% CI 0.02 to 0.19), compared with the ingestion of a placebo.	Caffeine	0-8	epiregulin	Homo sapiens	52-54
35616851-11	2022	CONCLUSION: Caffeine ingestion of 6 mg/kg body mass ~ 1 h before exercise in the heat may provide a worthwhile improvement in EP, is unlikely to be deleterious to EP, and trivially increases the rate of change in CT.	Caffeine	12-20	epiregulin	Homo sapiens	126-128
35616851-11	2022	CONCLUSION: Caffeine ingestion of 6 mg/kg body mass ~ 1 h before exercise in the heat may provide a worthwhile improvement in EP, is unlikely to be deleterious to EP, and trivially increases the rate of change in CT.	Caffeine	12-20	epiregulin	Homo sapiens	163-165
35536225-0	2022	Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation.	Caffeine	0-8	myeloid differentiation primary response gene 88	Mus musculus	100-105
35536225-2	2022	This work aims to evaluate the therapeutic efficacy of caffeine in a NASH mouse model displaying increased hepatic lipogenesis driven by constitutive hepatic overexpression of the active v-akt murine thymoma viral oncogene homolog (AKT).	Caffeine	55-63	thymoma viral proto-oncogene 1	Mus musculus	232-235
35615306-0	2022	Effects of caffeine ingestion and thermotherapy on blood orexin circulation in humans.	Caffeine	11-19	hypocretin neuropeptide precursor	Homo sapiens	57-63
35615306-3	2022	However, little is known about the combined effects of thermotherapy and caffeine intake on human serum orexin concentrations.	Caffeine	73-81	hypocretin neuropeptide precursor	Homo sapiens	104-110
35615306-6	2022	After thermotherapy (half-body immersion in a hot water bath at 42 +- 0.5  C, circulating orexin level increased more (p < 0.05) in the CAFF group than in the CON group.	Caffeine	136-140	hypocretin neuropeptide precursor	Homo sapiens	90-96
35615306-8	2022	Caffeine intake boosted the upregulation of serum orexin concentrations in subjects undergoing thermotherapy.	Caffeine	0-8	hypocretin neuropeptide precursor	Homo sapiens	50-56
35536225-6	2022	Mechanistically, caffeine repressed the AKT/mTORC1 and SREBP-1/ACC/FASN signaling in mice and in vitro.	Caffeine	17-25	thymoma viral proto-oncogene 1	Mus musculus	40-43
35536225-6	2022	Mechanistically, caffeine repressed the AKT/mTORC1 and SREBP-1/ACC/FASN signaling in mice and in vitro.	Caffeine	17-25	CREB regulated transcription coactivator 1	Mus musculus	44-50
35536225-6	2022	Mechanistically, caffeine repressed the AKT/mTORC1 and SREBP-1/ACC/FASN signaling in mice and in vitro.	Caffeine	17-25	sterol regulatory element binding transcription factor 1	Mus musculus	55-62
35536225-6	2022	Mechanistically, caffeine repressed the AKT/mTORC1 and SREBP-1/ACC/FASN signaling in mice and in vitro.	Caffeine	17-25	anterior capsular cataract	Mus musculus	63-66
35536225-6	2022	Mechanistically, caffeine repressed the AKT/mTORC1 and SREBP-1/ACC/FASN signaling in mice and in vitro.	Caffeine	17-25	fatty acid synthase	Mus musculus	67-71
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-40
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	67-79
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	interleukin 6	Mus musculus	135-148
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	interleukin 6	Mus musculus	150-154
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	tumor necrosis factor	Mus musculus	160-187
35536225-7	2022	Furthermore, caffeine impaired NF-kappaB activation by stabilizing IkappaBalpha, resulting in a reduction of proinflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Caffeine	13-21	tumor necrosis factor	Mus musculus	189-198
35536225-8	2022	Notably, caffeine abolished mTORC1/FASN-dependent MyD88 palmitoylation, which could be essential for its anti-inflammatory potential.	Caffeine	9-17	CREB regulated transcription coactivator 1	Mus musculus	28-34
35536225-8	2022	Notably, caffeine abolished mTORC1/FASN-dependent MyD88 palmitoylation, which could be essential for its anti-inflammatory potential.	Caffeine	9-17	fatty acid synthase	Mus musculus	35-39
35536225-8	2022	Notably, caffeine abolished mTORC1/FASN-dependent MyD88 palmitoylation, which could be essential for its anti-inflammatory potential.	Caffeine	9-17	myeloid differentiation primary response gene 88	Mus musculus	50-55
35507695-7	2022	Caffeine (38 wt %) was incorporated in CAF@MIL-53(Al) microcapsules, as analyzed by TGA and corroborated by GC/MS and UV-vis after additive extraction.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	39-49
35507695-8	2022	CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25  C (up to 22% of the initial caffeine).	Caffeine	60-68	lysine acetyltransferase 2B	Homo sapiens	0-10
35507695-8	2022	CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25  C (up to 22% of the initial caffeine).	Caffeine	118-126	lysine acetyltransferase 2B	Homo sapiens	0-10
35567477-9	2022	We show that the Esa1 lysine acetyltransferase activity is critical for suppression of the caffeine sensitive growth of H3K36R mutant cells while the previously characterized binding interactions of Tos4 and Pho92 are not required for suppression.	Caffeine	91-99	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	17-21
35588619-0	2022	Intrauterine programming of cartilaginous 11beta-HSD2 induced by corticosterone and caffeine mediated susceptibility to adult osteoarthritis.	Caffeine	84-92	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	42-53
35588619-8	2022	Moreover, caffeine could reduce the expression of 11beta-HSD2 by inhibiting the cAMP/PKA signaling pathway but without reducing the H3K9ac and H3K27ac levels of 11beta-HSD2, thereby synergistically enhancing the corticosterone effect.	Caffeine	10-18	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	50-61
35583696-12	2022	In the exploratory analysis by ER/PR status, we found a positive association of caffeine with ER+ /PR+ BCa (2nd vs. 1st tertile SHR = 1.17, 95% CI 1.07-1.28, 3rd vs. 1st tertile SHR = 1.13, 95% CI 1.03-1.24, overall p = 0.002); no associations were observed for ER-/PR- tumors.	Caffeine	80-88	epiregulin	Homo sapiens	31-33
35583696-12	2022	In the exploratory analysis by ER/PR status, we found a positive association of caffeine with ER+ /PR+ BCa (2nd vs. 1st tertile SHR = 1.17, 95% CI 1.07-1.28, 3rd vs. 1st tertile SHR = 1.13, 95% CI 1.03-1.24, overall p = 0.002); no associations were observed for ER-/PR- tumors.	Caffeine	80-88	epiregulin	Homo sapiens	94-96
35583696-12	2022	In the exploratory analysis by ER/PR status, we found a positive association of caffeine with ER+ /PR+ BCa (2nd vs. 1st tertile SHR = 1.17, 95% CI 1.07-1.28, 3rd vs. 1st tertile SHR = 1.13, 95% CI 1.03-1.24, overall p = 0.002); no associations were observed for ER-/PR- tumors.	Caffeine	80-88	epiregulin	Homo sapiens	262-264
35583696-15	2022	The higher caffeine consumption was mildly and positively associated with the overall BCa risk and with ER+ /PR+ tumors.	Caffeine	11-19	epiregulin	Homo sapiens	104-106
35567477-9	2022	We show that the Esa1 lysine acetyltransferase activity is critical for suppression of the caffeine sensitive growth of H3K36R mutant cells while the previously characterized binding interactions of Tos4 and Pho92 are not required for suppression.	Caffeine	91-99	mRNA-binding phosphate metabolism regulator	Saccharomyces cerevisiae S288C	208-213
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Caffeine	11-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Caffeine	11-19	RELB proto-oncogene, NF-kB subunit	Homo sapiens	189-193
35366604-5	2022	We first aimed to confirm previous findings for caffeine-induced enhancement on these executive components and on their associated electrophysiological indexes (The Attention-P3 component, response conflict NoGo-N2 and inhibition NoGo-P3 components (ii vs iii contrast); and then to test the hypotheses that expectations also induce these effects (i vs ii), although with a weaker amplitude (i vs iii).	Caffeine	48-56	reticulon 4	Homo sapiens	207-211
35579146-6	2022	Furthermore, caffeine TSG could significantly restore the cognitive ability by ameliorating neuronal cell injuries by upregulating brain-derived neurotrophic factor (BDNF) levels.	Caffeine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	131-164
35579146-6	2022	Furthermore, caffeine TSG could significantly restore the cognitive ability by ameliorating neuronal cell injuries by upregulating brain-derived neurotrophic factor (BDNF) levels.	Caffeine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	166-170
35622246-5	2022	Thus, inhibition of inducible nitric oxide synthase has a beneficial effect on the cognitive functions in offspring perinatally receiving caffeine.	Caffeine	138-146	nitric oxide synthase 2	Rattus norvegicus	20-51
35366604-5	2022	We first aimed to confirm previous findings for caffeine-induced enhancement on these executive components and on their associated electrophysiological indexes (The Attention-P3 component, response conflict NoGo-N2 and inhibition NoGo-P3 components (ii vs iii contrast); and then to test the hypotheses that expectations also induce these effects (i vs ii), although with a weaker amplitude (i vs iii).	Caffeine	48-56	reticulon 4	Homo sapiens	230-234
35366604-7	2022	At the electrophysiological level, however, we confirmed that caffeine increased the Attention-P3 and NoGo-P3 components amplitude but did not confirm an effect on the response-conflict N2 component.	Caffeine	62-70	reticulon 4	Homo sapiens	102-106
35591300-7	2022	The amount of caffeine in different marketed ED (ED1-ED10) was recorded in the range of 21.02-37.52 mg 100 mL-1 using the developed HPTLC method.	Caffeine	14-22	ectodysplasin A	Homo sapiens	49-57
35100330-2	2022	The aryl-hydrocarbon receptor (AhR) is an important transcription factor that regulates an enzyme related to the caffeine metabolism pathway.	Caffeine	113-121	aryl hydrocarbon receptor	Homo sapiens	4-29
35100330-2	2022	The aryl-hydrocarbon receptor (AhR) is an important transcription factor that regulates an enzyme related to the caffeine metabolism pathway.	Caffeine	113-121	aryl hydrocarbon receptor	Homo sapiens	31-34
35445349-7	2022	In contrast, in vivo isometric torque, ex vivo isometric force and ex vivo caffeine-induced force were all reduced 56-67% (p < 0.001) in mdx muscle and did not differ from one another (p = 0.114).	Caffeine	75-83	dystrophin, muscular dystrophy	Mus musculus	137-140
35445349-9	2022	In mdx muscle, the proportional reductions in isometric strength and caffeine-induced force following ECC contractions reveal that dysfunction occurs at and/or distal to the RyRs immediately post-injury.	Caffeine	69-77	dystrophin, muscular dystrophy	Mus musculus	3-6
35283111-8	2022	CSZ or CSZ plus caffeine reversed low glutamate gene expression, elevated cholinesterase level, and elevated caspase-3 activity in T2D rats.	Caffeine	16-24	butyrylcholinesterase	Rattus norvegicus	74-88
35283111-8	2022	CSZ or CSZ plus caffeine reversed low glutamate gene expression, elevated cholinesterase level, and elevated caspase-3 activity in T2D rats.	Caffeine	16-24	caspase 3	Rattus norvegicus	109-118
35283111-9	2022	Furthermore, CSZ plus caffeine was significantly more effective than CSZ or caffeine in inhibiting the increase in malondialdehyde (MDA) level, total oxidative stress, pro-inflammatory cytokines and glucogen synthase kinase-3 beta (GSK-3beta) in the hippocampus of T2D rats.	Caffeine	22-30	glycogen synthase kinase 3 alpha	Rattus norvegicus	232-241
35283111-12	2022	The enhancement of CSZ effect by caffeine is attributed to the increased inhibitory effect of CSZ on insulin resistance, GSK-3beta activity, hypercholesterolemia, oxidative stress and pro-inflammatory cytokines.	Caffeine	33-41	glycogen synthase kinase 3 alpha	Rattus norvegicus	121-130
35458179-0	2022	Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women.	Caffeine	62-70	alkaline phosphatase, placental	Homo sapiens	91-111
35458179-7	2022	Adjusted regression models identified an association between higher caffeine intake and lower ALP level only among vitamin D-sufficient pregnant women (beta = -0.24, p = 0.006), but not in those with insufficient vitamin D (beta = -0.02, p = 0.912).	Caffeine	68-76	alkaline phosphatase, placental	Homo sapiens	94-97
35384065-0	2022	Efficacy of Caffeine in ADCY5-Related Dyskinesia: A Retrospective Study.	Caffeine	12-20	adenylate cyclase 5	Homo sapiens	24-29
35384065-3	2022	OBJECTIVE: The aim is to obtain further insight into the efficacy and safety of caffeine in patients with ADCY5-related dyskinesia.	Caffeine	80-88	adenylate cyclase 5	Homo sapiens	106-111
35384065-4	2022	METHODS: A retrospective study was conducted worldwide in 30 patients with a proven ADCY5 mutation who had tried or were taking caffeine for dyskinesia.	Caffeine	128-136	adenylate cyclase 5	Homo sapiens	84-89
35384065-9	2022	CONCLUSION: Our findings suggest that caffeine should be considered as a first-line therapeutic option in ADCY5-related dyskinesia.	Caffeine	38-46	adenylate cyclase 5	Homo sapiens	106-111
35406079-12	2022	Caffeine ingestion also resulted in higher total offensive success during SSG 1 and SSG2, but it was detrimental during SSG3.	Caffeine	0-8	coiled-coil domain containing 80	Homo sapiens	74-79
35001424-0	2022	Adenosine A2A Receptor Occupancy by Caffeine After Coffee Intake in Parkinson"s Disease.	Caffeine	36-44	adenosine A2a receptor	Homo sapiens	13-22
35001424-2	2022	Its beneficial effects are allegedly mediated by caffeine through adenosine A2A receptor (A2A R) antagonist action.	Caffeine	49-57	adenosine A2a receptor	Homo sapiens	79-88
35001424-2	2022	Its beneficial effects are allegedly mediated by caffeine through adenosine A2A receptor (A2A R) antagonist action.	Caffeine	49-57	adenosine A2a receptor	Homo sapiens	93-95
35001424-8	2022	CONCLUSIONS: A sufficient A2A R occupancy can be obtained by drinking a cup of coffee, which is equivalent to approximately 100 mg of caffeine.	Caffeine	134-142	adenosine A2a receptor	Homo sapiens	29-31
35171455-1	2022	BACKGROUND: Experimental data indicate that caffeine (CAF) can reduce the anticonvulsant activity of antiepileptic drugs (AEDs) in animal models of seizures.	Caffeine	44-52	caffeine susceptibility	Mus musculus	54-57
35359205-7	2022	The ecological risk assessment revealed a great environmental concern for Sao Vicente Island, ranging between low (e.g. carbamazepine and cocaine) and moderate to high (e.g. caffeine, acetaminophen and losartan) threats for the aquatic biota.	Caffeine	174-182	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	74-77
35245048-4	2022	We found that tea leaves contained significantly higher caffeine than coffee leaves, which is perhaps due to more members of N-methyltransferase (NMT) genes as well as higher expression levels in tea plants.	Caffeine	56-64	N-myristoyltransferase 1	Homo sapiens	146-149
35456580-10	2022	Oral gavage of caffeine also suppressed the Mrp4 expression in the intestines of mice.	Caffeine	15-23	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	44-48
35245048-5	2022	Substantial numbers of transcription factors were predicted to be involved in caffeine biosynthesis regulation, combining weighted gene co-expression network analysis and the cis-element of NMT promoter analysis in tea and coffee plants.	Caffeine	78-86	N-myristoyltransferase 1	Homo sapiens	190-193
35369094-9	2022	Results: Caffeine concentrations were significantly varied among all coffees (DC vs. MDC, PC, SB, NIN, MIN p < 0.05).	Caffeine	9-17	chemokine (C-C motif) ligand 22	Mus musculus	85-88
35369094-9	2022	Results: Caffeine concentrations were significantly varied among all coffees (DC vs. MDC, PC, SB, NIN, MIN p < 0.05).	Caffeine	9-17	ninein	Mus musculus	98-101
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	NLR family, pyrin domain containing 3	Rattus norvegicus	28-33
35065262-0	2022	Caffeine mitigates experimental nonalcoholic steatohepatitis and the progression of thioacetamide-induced liver fibrosis by blocking the MAPK and TGF-beta/Smad3 signaling pathways.	Caffeine	0-8	transforming growth factor alpha	Rattus norvegicus	146-154
35065262-0	2022	Caffeine mitigates experimental nonalcoholic steatohepatitis and the progression of thioacetamide-induced liver fibrosis by blocking the MAPK and TGF-beta/Smad3 signaling pathways.	Caffeine	0-8	SMAD family member 3	Rattus norvegicus	155-160
35065262-9	2022	Caffeine prevented the progression of liver fibrosis by decreasing transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA) expression and by inhibiting the activation of mitogen-activated protein kinases (MAPKs) and Smad3 phosphorylation.	Caffeine	0-8	transforming growth factor alpha	Rattus norvegicus	100-108
35065262-9	2022	Caffeine prevented the progression of liver fibrosis by decreasing transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA) expression and by inhibiting the activation of mitogen-activated protein kinases (MAPKs) and Smad3 phosphorylation.	Caffeine	0-8	cellular communication network factor 2	Rattus norvegicus	111-142
35065262-9	2022	Caffeine prevented the progression of liver fibrosis by decreasing transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA) expression and by inhibiting the activation of mitogen-activated protein kinases (MAPKs) and Smad3 phosphorylation.	Caffeine	0-8	cellular communication network factor 2	Rattus norvegicus	144-148
35065262-9	2022	Caffeine prevented the progression of liver fibrosis by decreasing transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA) expression and by inhibiting the activation of mitogen-activated protein kinases (MAPKs) and Smad3 phosphorylation.	Caffeine	0-8	actin gamma 2, smooth muscle	Rattus norvegicus	155-180
35065262-9	2022	Caffeine prevented the progression of liver fibrosis by decreasing transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA) expression and by inhibiting the activation of mitogen-activated protein kinases (MAPKs) and Smad3 phosphorylation.	Caffeine	0-8	SMAD family member 3	Rattus norvegicus	286-291
35065262-10	2022	CONCLUSIONS: Caffeine attenuates NASH and the progression of liver fibrosis due to its antifibrotic effects and modulating the MAPK and TGF-beta pathways.	Caffeine	13-21	transforming growth factor alpha	Rattus norvegicus	136-144
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	interleukin 10	Rattus norvegicus	406-411
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	transforming growth factor alpha	Rattus norvegicus	416-424
35220399-5	2022	Importantly, we found that these caffeine-mediated effects could be reversed after inhibiting A2aR activity.	Caffeine	33-41	adenosine A2a receptor	Rattus norvegicus	94-98
35220399-6	2022	CONCLUSIONS: Caffeine improved long-term cognitive function in neonatal rats with hypoxic-ischemic WMD via A2aR-mediated inhibition of NLRP3 inflammasome activation, reduction of microglial activation, regulation of the phenotypic polarization of microglia and the release of inflammatory factors, and improvement of myelination development.	Caffeine	13-21	adenosine A2a receptor	Rattus norvegicus	107-111
35220399-6	2022	CONCLUSIONS: Caffeine improved long-term cognitive function in neonatal rats with hypoxic-ischemic WMD via A2aR-mediated inhibition of NLRP3 inflammasome activation, reduction of microglial activation, regulation of the phenotypic polarization of microglia and the release of inflammatory factors, and improvement of myelination development.	Caffeine	13-21	NLR family, pyrin domain containing 3	Rattus norvegicus	135-140
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	allograft inflammatory factor 1	Rattus norvegicus	78-83
35220399-10	2022	We found that caffeine pretreatment reduced WMD in immature brains via regulation of microglial activation and polarization by adenosine A2a receptor, thereby, providing a scientific basis for future clinical application of caffeine.	Caffeine	14-22	adenosine A2a receptor	Rattus norvegicus	127-149
35220399-10	2022	We found that caffeine pretreatment reduced WMD in immature brains via regulation of microglial activation and polarization by adenosine A2a receptor, thereby, providing a scientific basis for future clinical application of caffeine.	Caffeine	224-232	adenosine A2a receptor	Rattus norvegicus	127-149
35280254-2	2021	Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 enzyme system to the main product paraxanthine and the additional products theobromine and theophylline.	Caffeine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-79
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	CD86 molecule	Rattus norvegicus	190-194
35280254-3	2021	Besides its stimulating properties, two important applications of caffeine are metabolic phenotyping of cytochrome P450 1A2 (CYP1A2) and liver function testing.	Caffeine	66-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	104-123
35280254-3	2021	Besides its stimulating properties, two important applications of caffeine are metabolic phenotyping of cytochrome P450 1A2 (CYP1A2) and liver function testing.	Caffeine	66-74	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	nitric oxide synthase 2	Rattus norvegicus	199-203
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	tumor necrosis factor	Rattus norvegicus	276-285
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	interleukin 1 alpha	Rattus norvegicus	290-298
35220399-4	2022	RESULTS: Caffeine inhibited NLRP3 inflammasome activation, reduced microglial Iba-1 activation, inhibited microglia M1 polarization, and promoted microglia M2 polarization by downregulating CD86 and iNOS protein expression, inhibiting the transcription of the proinflammatory TNF-alpha and IL-1beta, upregulating CD206 and Arg-1 expression, and promoting the transcription of the anti-inflammatory factors IL-10 and TGF-beta.	Caffeine	9-17	arginase 1	Rattus norvegicus	323-328
35300350-5	2021	Caffeine arrests GBM cell cycle in G0/G1 phase by cyclin-dependent kinases (CDK) complex inhibition and by decreasing BCL-2 and increasing FOXO1 expression levels causing greater apoptotic activity.	Caffeine	0-8	BCL2 apoptosis regulator	Homo sapiens	118-123
35300350-5	2021	Caffeine arrests GBM cell cycle in G0/G1 phase by cyclin-dependent kinases (CDK) complex inhibition and by decreasing BCL-2 and increasing FOXO1 expression levels causing greater apoptotic activity.	Caffeine	0-8	forkhead box O1	Homo sapiens	139-144
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	mitogen-activated protein kinase 14	Homo sapiens	42-45
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	TIMP metallopeptidase inhibitor 1	Homo sapiens	185-221
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	TIMP metallopeptidase inhibitor 1	Homo sapiens	223-229
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	immunoglobulin kappa variable 2D-28	Homo sapiens	235-260
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	matrix metallopeptidase 2	Homo sapiens	306-311
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	matrix metallopeptidase 9	Homo sapiens	316-321
35203275-5	2022	While the same phenomenon is also triggered by single molecular interactions between epidermal growth factor (EGF) and its receptor EGFR, pharmacological studies with cetuximab, PD153035, and caffeine suggest EGF signaling crosstalk to DNA damaging response to mediate rapid mitochondrial fission as a result of nNIR irradiation.	Caffeine	192-200	epidermal growth factor	Homo sapiens	85-108
35172307-9	2022	CONCLUSION: The vertical and lateral penetration movement of caffeine was found to exceed that of LIP1 through the hydrophilic dermal environment.	Caffeine	61-69	lipoic acid synthetase	Homo sapiens	98-102
35203275-5	2022	While the same phenomenon is also triggered by single molecular interactions between epidermal growth factor (EGF) and its receptor EGFR, pharmacological studies with cetuximab, PD153035, and caffeine suggest EGF signaling crosstalk to DNA damaging response to mediate rapid mitochondrial fission as a result of nNIR irradiation.	Caffeine	192-200	epidermal growth factor	Homo sapiens	110-113
35203275-5	2022	While the same phenomenon is also triggered by single molecular interactions between epidermal growth factor (EGF) and its receptor EGFR, pharmacological studies with cetuximab, PD153035, and caffeine suggest EGF signaling crosstalk to DNA damaging response to mediate rapid mitochondrial fission as a result of nNIR irradiation.	Caffeine	192-200	epidermal growth factor receptor	Homo sapiens	132-136
35203275-5	2022	While the same phenomenon is also triggered by single molecular interactions between epidermal growth factor (EGF) and its receptor EGFR, pharmacological studies with cetuximab, PD153035, and caffeine suggest EGF signaling crosstalk to DNA damaging response to mediate rapid mitochondrial fission as a result of nNIR irradiation.	Caffeine	192-200	epidermal growth factor	Homo sapiens	209-212
35145399-11	2021	Of the 46 candidate SNPs in the CLOCK gene, 26 were found to be associated with determining the response to caffeine treatment in these babies.	Caffeine	108-116	clock circadian regulator	Homo sapiens	32-37
35140212-0	2022	Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.	Caffeine	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	16-22
35140212-0	2022	Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.	Caffeine	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	39-44
35140212-0	2022	Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.	Caffeine	0-8	low density lipoprotein receptor	Homo sapiens	67-71
35185566-1	2022	As a nonspecific antagonist of the adenosine A2A receptor (A2AR), caffeine enhances learning and improves memory impairment.	Caffeine	66-74	adenosine A2a receptor	Mus musculus	48-57
35185566-1	2022	As a nonspecific antagonist of the adenosine A2A receptor (A2AR), caffeine enhances learning and improves memory impairment.	Caffeine	66-74	adenosine A2a receptor	Mus musculus	59-63
35006304-8	2022	RESULTS: Caffeine administration was found to reduce the overall number of errors in patients and controls on the Stroop (p = .018, eta2p = .086) and Choice reaction time (p < .	Caffeine	9-17	DNA polymerase iota	Homo sapiens	132-137
35139770-5	2022	CYP1A2 showed reverse type I difference spectra with either beta-eudesmol or caffeine.	Caffeine	77-85	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
35139770-6	2022	The CYP1A2 affinity for beta-eudesmol was higher (0.23 mM) than for caffeine (0.37 mM) but lower than for phenacetin (0.11 mM, type I).	Caffeine	68-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
35145399-13	2021	Moreover, strong LD formed in those variants in AHR, ADORA2A, and CLOCK genes was confirmed to be significantly associated with a better response to standard-dose caffeine therapy.	Caffeine	163-171	aryl hydrocarbon receptor	Homo sapiens	48-51
35145399-13	2021	Moreover, strong LD formed in those variants in AHR, ADORA2A, and CLOCK genes was confirmed to be significantly associated with a better response to standard-dose caffeine therapy.	Caffeine	163-171	adenosine A2a receptor	Homo sapiens	53-60
35145399-13	2021	Moreover, strong LD formed in those variants in AHR, ADORA2A, and CLOCK genes was confirmed to be significantly associated with a better response to standard-dose caffeine therapy.	Caffeine	163-171	clock circadian regulator	Homo sapiens	66-71
35145399-14	2021	In summary, CLOCK gene polymorphisms play a role in determining the response to caffeine therapy in premature neonates with AOP.	Caffeine	80-88	clock circadian regulator	Homo sapiens	12-17
35145399-15	2021	However, whether the AHR and CLOCK signaling pathways crosstalk with each other during caffeine treatment remains largely unclear.	Caffeine	87-95	aryl hydrocarbon receptor	Homo sapiens	21-24
35145399-15	2021	However, whether the AHR and CLOCK signaling pathways crosstalk with each other during caffeine treatment remains largely unclear.	Caffeine	87-95	clock circadian regulator	Homo sapiens	29-34
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	85-116
35023427-0	2022	Adenosine receptor A2a blockade by caffeine increases IFN-gamma production in Th1 cells from patients with rheumatoid arthritis.	Caffeine	35-43	adenosine A2a receptor	Homo sapiens	0-22
35023427-0	2022	Adenosine receptor A2a blockade by caffeine increases IFN-gamma production in Th1 cells from patients with rheumatoid arthritis.	Caffeine	35-43	interferon gamma	Homo sapiens	54-63
35023427-2	2022	This study aimed to investigate the interplay between caffeine, adenosine receptor A2a, and interferon-gamma (IFN-gamma) production in CD4+ T cells from RA patients.	Caffeine	54-62	CD4 molecule	Homo sapiens	135-138
35023427-4	2022	CD4+ T cells were isolated using the magnetic activated cell sorting technique and cultured in vitro with caffeine or mock control.	Caffeine	106-114	CD4 molecule	Homo sapiens	0-3
35023427-8	2022	RESULTS: Caffeine promoted IFN-gamma production in Th1 cells in vitro.	Caffeine	9-17	interferon gamma	Homo sapiens	27-36
35023427-9	2022	Significantly higher concentrations of caffeine were required to increase IFN-gamma levels in Th1 cells from healthy individuals compared to Th1 cells from patients with RA.	Caffeine	39-47	interferon gamma	Homo sapiens	74-83
35012409-5	2022	Caffeine decreased cell proliferation, and induced autophagy flux via inhibition of MTOR signaling in these cells.	Caffeine	0-8	mechanistic target of rapamycin kinase	Mus musculus	84-88
35012409-6	2022	Genetic deletion of the key autophagy gene Atg5, and the Sqstm1/p62 gene encoding a receptor protein, showed that the anti-proliferative effect by caffeine was dependent upon autophagy.	Caffeine	147-155	autophagy related 5	Mus musculus	43-47
35012409-6	2022	Genetic deletion of the key autophagy gene Atg5, and the Sqstm1/p62 gene encoding a receptor protein, showed that the anti-proliferative effect by caffeine was dependent upon autophagy.	Caffeine	147-155	sequestosome 1	Mus musculus	57-63
35012409-6	2022	Genetic deletion of the key autophagy gene Atg5, and the Sqstm1/p62 gene encoding a receptor protein, showed that the anti-proliferative effect by caffeine was dependent upon autophagy.	Caffeine	147-155	sequestosome 1	Mus musculus	64-67
35012409-7	2022	Interestingly, caffeine also decreased WNT-signaling and the expression of two WNT target genes, Axin2 and Ccnd1 (cyclin D1).	Caffeine	15-23	axin 2	Mus musculus	97-102
35012409-7	2022	Interestingly, caffeine also decreased WNT-signaling and the expression of two WNT target genes, Axin2 and Ccnd1 (cyclin D1).	Caffeine	15-23	cyclin D1	Mus musculus	107-112
35012409-7	2022	Interestingly, caffeine also decreased WNT-signaling and the expression of two WNT target genes, Axin2 and Ccnd1 (cyclin D1).	Caffeine	15-23	cyclin D1	Mus musculus	114-123
35012409-8	2022	This effect was mediated by autophagic degradation of a key member of the WNT signaling cascade, DVL2, by caffeine to decrease WNT signaling and cell proliferation.	Caffeine	106-114	dishevelled segment polarity protein 2	Mus musculus	97-101
35012409-9	2022	SQSTM1/p62, MAP1LC3B-II and DVL2 were also shown to interact with each other, and the overexpression of DVL2 counteracted the inhibition of cell proliferation by caffeine.	Caffeine	162-170	sequestosome 1	Mus musculus	0-6
35012409-9	2022	SQSTM1/p62, MAP1LC3B-II and DVL2 were also shown to interact with each other, and the overexpression of DVL2 counteracted the inhibition of cell proliferation by caffeine.	Caffeine	162-170	sequestosome 1	Mus musculus	7-10
35012409-9	2022	SQSTM1/p62, MAP1LC3B-II and DVL2 were also shown to interact with each other, and the overexpression of DVL2 counteracted the inhibition of cell proliferation by caffeine.	Caffeine	162-170	microtubule-associated protein 1 light chain 3 beta	Mus musculus	12-20
35012409-9	2022	SQSTM1/p62, MAP1LC3B-II and DVL2 were also shown to interact with each other, and the overexpression of DVL2 counteracted the inhibition of cell proliferation by caffeine.	Caffeine	162-170	dishevelled segment polarity protein 2	Mus musculus	28-32
35012409-9	2022	SQSTM1/p62, MAP1LC3B-II and DVL2 were also shown to interact with each other, and the overexpression of DVL2 counteracted the inhibition of cell proliferation by caffeine.	Caffeine	162-170	dishevelled segment polarity protein 2	Mus musculus	104-108
35023427-11	2022	Caffeine-driven IFN-gamma production was completely reversed by adenosine, a competitive agonist of adenosine receptor A2a.	Caffeine	0-8	interferon gamma	Homo sapiens	16-25
35023427-11	2022	Caffeine-driven IFN-gamma production was completely reversed by adenosine, a competitive agonist of adenosine receptor A2a.	Caffeine	0-8	adenosine A2a receptor	Homo sapiens	100-122
35023427-13	2022	CONCLUSION: Caffeine promotes IFN-gamma production in Th1 cells from RA patients in vitro by competitive inhibition of adenosine receptor A2a.	Caffeine	12-20	interferon gamma	Homo sapiens	30-39
35023427-13	2022	CONCLUSION: Caffeine promotes IFN-gamma production in Th1 cells from RA patients in vitro by competitive inhibition of adenosine receptor A2a.	Caffeine	12-20	adenosine A2a receptor	Homo sapiens	119-141
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	118-123
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	220-225
35069225-9	2021	Retinal BDNF dropped significantly (p < 0.05) in the I/R group compared to the control group (normal mice); on the contrary, caffeine treatment maintained physiological levels of BDNF in the retina of I/R eyes.	Caffeine	125-133	brain derived neurotrophic factor	Mus musculus	179-183
35069225-10	2021	Caffeine was also able to reduce IL-6 mRNA levels in the retina of I/R eyes.	Caffeine	0-8	interleukin 6	Mus musculus	33-37
35063815-9	2022	A general linear model was performed to evaluate the relationship between caffeine intake and levels of serum ferritin, ferritin, soluble transferrin receptor, hepcidin, hemojuvelin, and hsCRP.	Caffeine	74-82	transferrin receptor	Homo sapiens	138-158
35063815-9	2022	A general linear model was performed to evaluate the relationship between caffeine intake and levels of serum ferritin, ferritin, soluble transferrin receptor, hepcidin, hemojuvelin, and hsCRP.	Caffeine	74-82	hepcidin antimicrobial peptide	Homo sapiens	160-168
35063815-9	2022	A general linear model was performed to evaluate the relationship between caffeine intake and levels of serum ferritin, ferritin, soluble transferrin receptor, hepcidin, hemojuvelin, and hsCRP.	Caffeine	74-82	hemojuvelin BMP co-receptor	Homo sapiens	170-181
35063815-13	2022	Greater caffeine intake was generally associated with greater serum hepcidin levels, with the strongest effect on moderate drinkers.	Caffeine	8-16	hepcidin antimicrobial peptide	Homo sapiens	68-76
35281252-1	2022	The aim of the present study was to test the binding affinity of methylxanthines (caffeine/theine, methylxanthine, theobromine, theophylline and xanthine) to three potential target proteins namely Spike protein (6LZG), main protease (6LU7) and nucleocapsid protein N-terminal RNA binding domain (6M3M) of SARS-CoV-2.	Caffeine	91-97	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	197-202