PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12919728-0	2003	Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane.	Halothane	138-147	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	73-79
12919728-2	2003	After halothane exposure, p-nitrophenol hydroxylase (p-NPH) activity increased 3.2-fold and CYP2E1 apo-protein content 7-fold in testes, whereas in liver, p-NPH increased 2.3-fold and CYP2E1 apoprotein content 1.4-fold.	Halothane	6-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	92-98
12919728-2	2003	After halothane exposure, p-nitrophenol hydroxylase (p-NPH) activity increased 3.2-fold and CYP2E1 apo-protein content 7-fold in testes, whereas in liver, p-NPH increased 2.3-fold and CYP2E1 apoprotein content 1.4-fold.	Halothane	6-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	184-190
12919728-3	2003	These results suggest a differential inductive effect of halothane on CYP2E1 in these tissues.	Halothane	57-66	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	70-76
12919728-8	2003	The increase in CYP2E1 apoprotein and p-NPH activity observed in testis and liver microsomes suggests that halothane induces its own biotransformation both hepatically and extrahepatically and in addition, that the nature of the TFA adducts will depend on the proteins present in each tissue.	Halothane	107-116	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	16-22
12909676-10	2003	However, when Mg2+-induced inhibition of the ryanodine receptor (RYR) is reduced, levels of halothane within the range found during anaesthesia can induce a marked efflux of Ca2+ from the SR.	Halothane	92-101	ryanodine receptor 2	Rattus norvegicus	45-63
12909676-10	2003	However, when Mg2+-induced inhibition of the ryanodine receptor (RYR) is reduced, levels of halothane within the range found during anaesthesia can induce a marked efflux of Ca2+ from the SR.	Halothane	92-101	ryanodine receptor 2	Rattus norvegicus	65-68
12826849-6	2003	RESULTS: The steady state GTPase-specific activity of the recombinant Galpha(i1) was 0.033 +/- 0.018 (mean +/- SD) mole P(i) mole Galpha(i1)-1 min-1 under control conditions and 0.035 +/- 0.015 mole P(i) mole Galpha(i1)-1 min-1 in the presence of 1.1 +/- 0.2 mm halothane, a difference that is not significant.	Halothane	262-271	nischarin	Homo sapiens	70-79
12803597-1	2003	BACKGROUND: Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immunologic cascade culminating in antibody formation and severe hepatic necrosis ("halothane hepatitis") in susceptible patients.	Halothane	61-70	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	31-37
12803597-3	2003	CYP2E1 inactivation by disulfiram or its primary metabolite, diethyldithiocarbamate, inhibits human halothane oxidation to TFA in vitro and in vivo.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
12803597-11	2003	CONCLUSIONS: Disulfiram inhibition of CYP2E1-mediated halothane oxidation prevents hepatic protein trifluoroacetylation.	Halothane	54-63	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	38-44
12818950-6	2003	Halothane (1.4%-2.2%) inhibited field excitatory postsynaptic potentials similarly in both genotypes, whereas 1%-2% halothane depressed PSs more in Ca(v)2.3(-/-) mice, suggesting the postsynaptic role of the R-type channel in the propagation of excitation and other mechanisms underlying the increased halothane MAC(RR) in Ca(v)2.3(-/-) mice.	Halothane	116-125	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	148-156
12826852-11	2003	It is proposed that the anesthetic-induced relaxation is via cPKC/MEK/ERK1/2 and CaMKII/p38 pathways and, in addition, via CaMKII-p/MLCK-p(-)/MLC-p(-) for halothane.	Halothane	155-164	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	132-136
12749994-0	2003	The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model.	Halothane	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-51
12749994-1	2003	We investigated the effect of an intrathecal injection of a selective alpha2 adrenergic receptor agonist, dexmedetomidine (Dex), and halothane anesthesia on Fos expression in the lumbar spinal dorsal horn after skin incision of the plantar surface of the hind paw, a postoperative pain model using rats.	Halothane	133-142	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	157-160
12749994-3	2003	Halothane anesthesia (0.5-1.5%) partially reversed Fos induction, but not in a dose-dependent manner.	Halothane	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Halothane	9-18	interleukin 6	Rattus norvegicus	149-162
12536043-0	2003	Facilitatory action of halothane at subanesthetic concentrations on glutamatergic excitatory synaptic transmission in the CA1 area of adult rat hippocampus.	Halothane	23-32	carbonic anhydrase 1	Rattus norvegicus	122-125
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Halothane	9-18	C-X-C motif chemokine ligand 2	Rattus norvegicus	164-169
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Halothane	9-18	C-C motif chemokine ligand 2	Rattus norvegicus	175-180
12502982-8	2003	Halothane exposure decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1 in a dose- and time-dependent manner.	Halothane	0-9	interleukin 6	Rattus norvegicus	76-89
12502982-8	2003	Halothane exposure decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1 in a dose- and time-dependent manner.	Halothane	0-9	C-X-C motif chemokine ligand 2	Rattus norvegicus	91-96
12502982-8	2003	Halothane exposure decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1 in a dose- and time-dependent manner.	Halothane	0-9	C-C motif chemokine ligand 2	Rattus norvegicus	102-107
12502982-10	2003	These effects were transient as rmIL-1beta-stimulated AT II cell secretions of interleukin-6 and MIP-2 progressively reached control values between 4 and 24 h after the end of halothane exposure.	Halothane	176-185	C-X-C motif chemokine ligand 2	Rattus norvegicus	97-102
12502982-11	2003	However, MCP-1 inhibition persisted until 24 h. rmIL-1beta-induced MIP-2 and tumor necrosis factor-alpha mRNA expression were decreased by 36 and 24%, respectively, after halothane exposure.	Halothane	171-180	C-C motif chemokine ligand 2	Rattus norvegicus	9-14
12502982-11	2003	However, MCP-1 inhibition persisted until 24 h. rmIL-1beta-induced MIP-2 and tumor necrosis factor-alpha mRNA expression were decreased by 36 and 24%, respectively, after halothane exposure.	Halothane	171-180	C-X-C motif chemokine ligand 2	Rattus norvegicus	67-104
12505937-6	2003	Volatile anesthetics did not attenuate the release of CGRP after spinal cord stimulation, whereas isoflurane at 2% and halothane at 1.5% significantly inhibited depressor responses to exogenously administered CGRP.	Halothane	119-128	calcitonin-related polypeptide alpha	Rattus norvegicus	209-213
12505937-8	2003	Thus, isoflurane and halothane at large concentrations attenuate NANC depressor responses by attenuating the depressor action of CGRP, not CGRP release.	Halothane	21-30	calcitonin-related polypeptide alpha	Rattus norvegicus	129-133
12505937-9	2003	IMPLICATIONS: The anesthetics isoflurane and halothane attenuate nonadrenergic, noncholinergic depressor responses mediated by calcitonin gene-related peptide in the rat without affecting the release of the peptide.	Halothane	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	127-158
12675482-11	2003	Caspase-1 gene expression is distinctly upregulated after light exposure and there are several factors which completely protect against light-induced cell death, such as the anesthetic halothane, dexamethasone and the absence of bleachable rhodopsin during light exposure.	Halothane	185-194	caspase 1	Homo sapiens	0-9
12487152-4	2002	CYP2A6 can metabolize some pharmaceutical agents such as halothane, valproic acid, and fadrozole, and activate tobacco-specific nitrosamines.	Halothane	57-66	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
12151923-2	2002	This study was designed to investigate the effects of different mutations in the RYR1 gene on contracture development in in vitro contracture tests (IVCT) with halothane, caffeine, and ryanodine.	Halothane	160-169	ryanodine receptor 1	Homo sapiens	81-85
12587265-0	2002	[C-fos gene expression in the rat spinal cord and brain cells during stress and the use of different types of halothane anesthesia].	Halothane	110-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	1-6
12587265-2	2002	Using of 1.5% light halothane narcosis allowed the detection of c-Fos-like proteins expression in the spinal cord cells only.	Halothane	20-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
12587265-3	2002	Under initial 1.5% halothane narcosis, c-Fos-like proteins expression in the rat spinal cord (lumbar segments) and the brain cells was observed after placing the rats into the hammock, noxious mechanical stimulation (NMS) or high frequency electromagnetic irradiation of the skin (EHF).	Halothane	19-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
12234619-1	2002	While almost anesthetics are metabolized by the cytochrome P450 (CYP) 3A4, some major volatile ones such as halothane and sevoflurane are metabolized by CYP2E1 in humans.	Halothane	108-117	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	153-159
12393358-3	2002	Our aim was to establish if measurements of halothane-induced increases in intracellular calcium ion concentration [Ca(2+)](i) in cultured human skeletal muscle cells can be used to phenotype MH susceptibility and if different mutations in the ryanodine receptor (RYR1) gene affect halothane-induced increases in [Ca(2+)](i).	Halothane	44-53	ryanodine receptor 1	Homo sapiens	264-268
12176752-6	2002	In contrast, Cx31.9 channels were gated by cytoplasmic acidification or exposure to halothane like other connexins.	Halothane	84-93	gap junction protein delta 3	Homo sapiens	13-19
12198041-3	2002	spA mice were also more sensitive to halothane (P < 0.001) in the loss-of-righting reflex assay (EC(50) = 0.81 +/- 0.03 atm for controls versus 0.57 +/- 0.04 atm for spA), but the responses of mutant and control mice to tail clamp in the presence of halothane were similar.	Halothane	37-46	glycine receptor, beta subunit	Mus musculus	0-3
12198041-3	2002	spA mice were also more sensitive to halothane (P < 0.001) in the loss-of-righting reflex assay (EC(50) = 0.81 +/- 0.03 atm for controls versus 0.57 +/- 0.04 atm for spA), but the responses of mutant and control mice to tail clamp in the presence of halothane were similar.	Halothane	37-46	glycine receptor, beta subunit	Mus musculus	169-172
12198041-3	2002	spA mice were also more sensitive to halothane (P < 0.001) in the loss-of-righting reflex assay (EC(50) = 0.81 +/- 0.03 atm for controls versus 0.57 +/- 0.04 atm for spA), but the responses of mutant and control mice to tail clamp in the presence of halothane were similar.	Halothane	253-262	glycine receptor, beta subunit	Mus musculus	0-3
12351264-4	2002	At clinical concentrations, human NET was inhibited only by halothane (50% inhibitory concentration [IC(50)] = 0.54 mM), rat DAT was sensitive to both halothane and isoflurane (IC(50) = 0.60 and 0.64 mM, respectively), and rat GAT-1 was insensitive to both volatile anesthetics.	Halothane	151-160	solute carrier family 6 member 3	Rattus norvegicus	125-128
12357160-0	2002	Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane.	Halothane	73-82	potassium voltage-gated channel subfamily H member 2	Homo sapiens	22-26
12357160-2	2002	General anesthetics, like halothane, can prolong Q-T interval, suggesting that they act on myocellular repolarization, possibly involving HERG channels.	Halothane	26-35	potassium voltage-gated channel subfamily H member 2	Homo sapiens	138-142
12357160-3	2002	Evidence for direct modulation of HERG channels by halothane is still lacking.	Halothane	51-60	potassium voltage-gated channel subfamily H member 2	Homo sapiens	34-38
12357160-4	2002	To gain insight on HERG channel modulation by halothane the authors recorded macroscopic currents expressed in Xenopus oocytes and conducted non-stationary noise analysis to evaluate single channel parameters modified by the anesthetic.	Halothane	46-55	potassium voltage-gated channel subfamily H member 2	Homo sapiens	19-23
12357160-12	2002	CONCLUSIONS: Halothane inhibits HERG currents expressed in oocytes in a concentration-dependent manner.	Halothane	13-22	potassium voltage-gated channel subfamily H member 2	Homo sapiens	32-36
12357160-14	2002	The authors" results demonstrate that halothane decreased HERG currents by modulating kinetic properties of HERG channels, decreasing their open probability.	Halothane	38-47	potassium voltage-gated channel subfamily H member 2	Homo sapiens	58-62
12357160-14	2002	The authors" results demonstrate that halothane decreased HERG currents by modulating kinetic properties of HERG channels, decreasing their open probability.	Halothane	38-47	potassium voltage-gated channel subfamily H member 2	Homo sapiens	108-112
12151923-10	2002	CONCLUSIONS: The differences between the groups in the halothane and caffeine IVCT threshold concentrations and in the time course of contracture development in the ryanodine IVCT underline the hypothesis that certain mutations in the RYR1 gene could make the ryanodine receptor more sensitive to specific ligands.	Halothane	55-64	ryanodine receptor 1	Homo sapiens	235-239
12124989-8	2002	RYR1 mutations associated with both CCD and MH (R163C, R2163H, R2435H) had more severe caffeine and halothane response phenotypes than those associated with MH alone.	Halothane	100-109	ryanodine receptor 1	Homo sapiens	0-4
12051698-2	2002	Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane, we found that toxicity was commensurate with an increase in serum macrophage migration inhibitory factor (MIF), a pro-inflammatory signal and counter-regulator of glucocorticoids, but only in susceptible animals.	Halothane	90-99	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	167-205
12135952-9	2002	Differences in KCNE1 may contribute to sex differences uncovered by halothane.	Halothane	68-77	potassium voltage-gated channel, Isk-related subfamily, member 1	Mus musculus	15-20
12051698-2	2002	Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane, we found that toxicity was commensurate with an increase in serum macrophage migration inhibitory factor (MIF), a pro-inflammatory signal and counter-regulator of glucocorticoids, but only in susceptible animals.	Halothane	90-99	macrophage migration inhibitory factor	Cavia porcellus	207-210
11886861-3	2002	To clarify these mechanisms, we generated mutant channels and found that alterations disrupting anesthetic (halothane) activation of these channels also disrupted transmitter (thyrotropin-releasing hormone, TRH) inhibition and did so to a similar degree.	Halothane	108-117	thyrotropin releasing hormone	Homo sapiens	176-205
22064000-1	2002	The objective of this study was to determine the impact of myosin heavy chain (MyHC) isoforms (I, IIB, IIA and IIX) on pork quality traits of halothane (HAL)-negative (NN) and halothane-carrier (Nn) pigs.	Halothane	142-151	myosin heavy chain 3	Sus scrofa	59-77
22064000-1	2002	The objective of this study was to determine the impact of myosin heavy chain (MyHC) isoforms (I, IIB, IIA and IIX) on pork quality traits of halothane (HAL)-negative (NN) and halothane-carrier (Nn) pigs.	Halothane	142-151	myosin heavy chain 3	Sus scrofa	79-83
12429234-3	2002	This novel form of longitudinally arranged Cx 43 immunoreactivity was modified by dehydration and halothane exposure, but not lactation.	Halothane	98-107	gap junction protein, alpha 1	Rattus norvegicus	43-48
11886861-3	2002	To clarify these mechanisms, we generated mutant channels and found that alterations disrupting anesthetic (halothane) activation of these channels also disrupted transmitter (thyrotropin-releasing hormone, TRH) inhibition and did so to a similar degree.	Halothane	108-117	thyrotropin releasing hormone	Homo sapiens	207-210
11964597-12	2002	Potentiation of NCX-mediated Ca2+ efflux by extracellular Na+ and NCX-mediated Ca2+ influx by intracellular Na+ were both prevented by halothane, especially in neonates.	Halothane	135-144	solute carrier family 8 member A1	Rattus norvegicus	16-19
12019227-5	2002	Pheromone preparations from loss-of-function mutants of daf-22, a gene required for dauer pheromone production, lacked the halothane-resistance activity, suggesting that dauer and Pir pheromone are identical.	Halothane	123-132	Non-specific lipid-transfer protein-like 2	Caenorhabditis elegans	56-62
11961111-3	2002	We report herein the location of the binding site for the inhaled anesthetic halothane at the amino acid residue level of resolution in the ligand binding cavity in a prototypical G protein-coupled receptor, bovine rhodopsin.	Halothane	77-86	rhodopsin	Bos taurus	215-224
11961111-4	2002	Tryptophan fluorescence quenching and direct photoaffinity labeling with [(14)C]halothane suggested an interhelical location of halothane with a stoichiometry of 1 (halothane/rhodopsin molar ratio).	Halothane	128-137	rhodopsin	Bos taurus	175-184
11961111-5	2002	Radiosequence analysis of [(14)C]halothane-labeled rhodopsin revealed that halothane contacts an amino acid residue (Trp265) lining the ligand binding cavity in the transmembrane core of the receptor.	Halothane	33-42	rhodopsin	Bos taurus	51-60
11961111-5	2002	Radiosequence analysis of [(14)C]halothane-labeled rhodopsin revealed that halothane contacts an amino acid residue (Trp265) lining the ligand binding cavity in the transmembrane core of the receptor.	Halothane	75-84	rhodopsin	Bos taurus	51-60
11964597-12	2002	Potentiation of NCX-mediated Ca2+ efflux by extracellular Na+ and NCX-mediated Ca2+ influx by intracellular Na+ were both prevented by halothane, especially in neonates.	Halothane	135-144	solute carrier family 8 member A1	Rattus norvegicus	66-69
11741001-9	2002	Halothane decreased DA release in a concentration-dependent manner (FRS2/FRS1=0.767+/-0.021, 0.715+/-0.026, 0.671+/-0.014 and 0.639+/-0.033 at the concentration of 0, 0.5, 2 and 4%, respectively), while ACh release showed a biphasic change in the presence of different concentrations of halothane.	Halothane	0-9	fibroblast growth factor receptor substrate 2	Rattus norvegicus	68-72
11753011-8	2002	Surface expression of CD62P on ADP- and TRAP-6-stimulated platelets were significantly reduced after 1 and 2 MAC halothane.	Halothane	113-122	selectin P	Homo sapiens	22-27
11772805-5	2002	We examined the effects of halothane, isoflurane, enflurane, diethyl ether, and ethanol on SP-induced currents mediated by SPR expressed in Xenopus oocytes, by using a whole-cell voltage clamp.	Halothane	27-36	tachykinin precursor 1 S homeolog	Xenopus laevis	91-93
11772805-10	2002	IMPLICATIONS: We examined the effects of halothane, isoflurane, enflurane, diethyl ether, and ethanol on substance P receptor (SPR) expressed in Xenopus oocytes, by using a whole-cell voltage clamp.	Halothane	41-50	tachykinin precursor 1 S homeolog	Xenopus laevis	105-116
11684360-2	2001	In the in vitro experiments, all three compounds decreased olfactory CYP-dependent activities in microsomes from both species, especially under anaerobic conditions, halothane showing the greatest effect.	Halothane	166-175	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	69-72
11684360-4	2001	A selective olfactory CYP depletion was also observed in vivo after treatment with halothane, but not with HCFC-123 or HCFC-141b.	Halothane	83-92	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	22-25
11814301-5	2002	Using this approach we characterize halothane binding to serum albumin as low affinity and multisite, and to myoglobin or cytochrome C as strictly nonspecific.	Halothane	36-45	albumin	Homo sapiens	63-70
11834892-2	2002	Tryptophan fluorescence quenching has been used previously to show that halothane and chloroform bind saturably to serum albumin, and a similar approach is used here to demonstrate that TCE also binds to albumin.	Halothane	72-81	albumin	Homo sapiens	115-128
12020046-1	2002	The study investigated in vitro effects of halothane, isoflurane, ketamine, sevoflurane, prilocaine, diazepam, and midazolam on enzymatic activity of human red blood cell glucose-6-phosphate dehydrogenase (G6PD; E.C.	Halothane	43-52	glucose-6-phosphate dehydrogenase	Homo sapiens	171-204
11741593-0	2001	Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.	Halothane	119-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-51
11741593-3	2001	We demonstrate for the first time that the volatile anesthetic halothane blocks HIF-1 activity and downstream target gene expressions induced by hypoxia in the human hepatoma-derived cell line, Hep3B.	Halothane	63-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
11735261-2	2001	Halothane (H) has been shown to reduce conductance of connexin-43 hemichannels and to protect the heart against ischemic injury.	Halothane	0-9	gap junction alpha-1 protein	Oryctolagus cuniculus	54-65
11535057-1	2001	Halothane, an inhaled anesthetic, destabilizes the folded structure of myoglobin.	Halothane	0-9	myoglobin	Homo sapiens	71-80
11535057-4	2001	Halothane destabilizes myoglobin and binds with low affinity and stoichiometry but stabilizes and binds with higher affinity to apomyoglobin.	Halothane	0-9	myoglobin	Homo sapiens	23-32
11535057-8	2001	Guanidinium unfolding of myoglobin, monitored by CD spectroscopy, shows destabilization at less than 1.3 M Gdm but stabilization at greater than 1.3 M Gdm, consistent with the hypothesis that less stable conformers of myoglobin bind halothane preferentially.	Halothane	233-242	myoglobin	Homo sapiens	25-34
11524331-8	2001	In contrast, halothane reduced TRAP-6-induced activation of the GPIIb/IIIa complex.	Halothane	13-22	integrin subunit alpha 2b	Homo sapiens	64-69
11561259-8	2001	Halothane inhalation affected the results of both the behavior and the c-fos immunoreactivity, especially in the 10% formalin (3.7% formaldehyde) group.	Halothane	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
11434912-3	2001	In this study, we examined the induction of two heat shock proteins, heat shock protein 70 (HSP70) and heme oxygenase-1 (HO-1), in the livers of rats pretreated with or without phenobarbital, followed by exposure to isoflurane or halothane under hypoxic conditions.	Halothane	230-239	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	69-90
11506125-0	2001	Halothane but not isoflurane attenuates interleukin 1beta-induced nitric oxide synthase in vascular smooth muscle.	Halothane	0-9	interleukin 1 beta	Rattus norvegicus	40-57
11434912-3	2001	In this study, we examined the induction of two heat shock proteins, heat shock protein 70 (HSP70) and heme oxygenase-1 (HO-1), in the livers of rats pretreated with or without phenobarbital, followed by exposure to isoflurane or halothane under hypoxic conditions.	Halothane	230-239	heme oxygenase 1	Rattus norvegicus	121-125
11434912-4	2001	In the phenobarbital-pretreated rats, the maximal induction of HSP70 was observed by halothane-hypoxia treatment, followed by a half-maximal induction by isoflurane-hypoxia treatment, and less than 30% induction by hypoxia treatment alone.	Halothane	85-94	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	63-68
11434912-10	2001	These findings demonstrate that there is a significant difference in hepatic injury, and in the induction of HO-1 and HSP70 between halothane-hypoxia and isoflurane-hypoxia treatments.	Halothane	132-141	heme oxygenase 1	Rattus norvegicus	109-113
11434912-10	2001	These findings demonstrate that there is a significant difference in hepatic injury, and in the induction of HO-1 and HSP70 between halothane-hypoxia and isoflurane-hypoxia treatments.	Halothane	132-141	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	118-123
11515322-3	2001	Subsequent testing showed that isoflurane, as well as desflurane, sevoflurane, halothane and methoxyflurane, produce two ionization peaks in the CAM response.	Halothane	79-88	calmodulin 3	Homo sapiens	145-148
11506125-10	2001	Halothane at 3.0% significantly inhibited the increase in cyclic guanosine monophosphate content induced by IL-1beta.	Halothane	0-9	interleukin 1 beta	Rattus norvegicus	108-116
11506125-12	2001	IL-1beta-induced expression of iNOS and iNOS mRNA in the rat aorta were inhibited significantly by halothane.	Halothane	99-108	interleukin 1 beta	Rattus norvegicus	0-8
11506125-12	2001	IL-1beta-induced expression of iNOS and iNOS mRNA in the rat aorta were inhibited significantly by halothane.	Halothane	99-108	nitric oxide synthase 2	Rattus norvegicus	31-35
11506125-12	2001	IL-1beta-induced expression of iNOS and iNOS mRNA in the rat aorta were inhibited significantly by halothane.	Halothane	99-108	nitric oxide synthase 2	Rattus norvegicus	40-44
11506125-13	2001	CONCLUSION: The current study demonstrated that halothane but not isoflurane inhibits IL-1beta-stimulated hyporesponsiveness to vasoconstrictive agents in vascular smooth muscle and that this inhibitory effect of halothane involves the inhibition of iNOS mRNA expression.	Halothane	48-57	interleukin 1 beta	Rattus norvegicus	86-94
11506125-13	2001	CONCLUSION: The current study demonstrated that halothane but not isoflurane inhibits IL-1beta-stimulated hyporesponsiveness to vasoconstrictive agents in vascular smooth muscle and that this inhibitory effect of halothane involves the inhibition of iNOS mRNA expression.	Halothane	48-57	nitric oxide synthase 2	Rattus norvegicus	250-254
11506127-0	2001	Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).	Halothane	0-9	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	101-107
11506127-2	2001	Halothane is reduced under low oxygen tensions by CYP2A6 and CYP3A4 in human liver microsome to an unstable free radical, and then to the volatile metabolites chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE).	Halothane	0-9	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	50-56
11506127-2	2001	Halothane is reduced under low oxygen tensions by CYP2A6 and CYP3A4 in human liver microsome to an unstable free radical, and then to the volatile metabolites chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE).	Halothane	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67
11506127-12	2001	Halothane-dependent MDA production was catalyzed by cDNA-expressed CYP2A6 but not CYP3A4 or P450 reductase alone.	Halothane	0-9	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	67-73
11506127-12	2001	Halothane-dependent MDA production was catalyzed by cDNA-expressed CYP2A6 but not CYP3A4 or P450 reductase alone.	Halothane	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
11506127-14	2001	CONCLUSIONS: Halothane causes lipid peroxidation in human liver microsomes, which is catalyzed by CYP2A6, and inhibition of halothane reduction prevents halothane-dependent lipid peroxidation in vitro.	Halothane	13-22	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	98-104
11465552-6	2001	The neuronal-type GIRK1/2 channels were inhibited by 2 minimum alveolar concentrations of halothane or F3 by 45 and 81%, respectively, whereas the cardiac-type GIRK1/4 channels were inhibited only by F3.	Halothane	90-99	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	18-23
11455015-4	2001	Because of their key role in controlling excitability, we investigated the influence of a prototypic anesthetic, halothane, on GIRK channels of different subunit composition expressed in Xenopus laevis oocytes.	Halothane	113-122	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	127-131
11455015-5	2001	Halothane enhanced background currents through hetero-oligomeric GIRK1/GIRK4 and homo-oligomeric GIRK1(F137S) channels but not through homo-oligomeric GIRK2 channels.	Halothane	0-9	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	65-70
11455015-5	2001	Halothane enhanced background currents through hetero-oligomeric GIRK1/GIRK4 and homo-oligomeric GIRK1(F137S) channels but not through homo-oligomeric GIRK2 channels.	Halothane	0-9	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	71-76
11455015-5	2001	Halothane enhanced background currents through hetero-oligomeric GIRK1/GIRK4 and homo-oligomeric GIRK1(F137S) channels but not through homo-oligomeric GIRK2 channels.	Halothane	0-9	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	97-102
11455015-7	2001	In contrast to basal GIRK currents, the agonist-induced GIRK current (via coexpressed m2 muscarinic receptors) was inhibited by halothane.	Halothane	128-137	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	56-60
11455015-12	2001	These data suggest a direct interaction of halothane with GIRK channels.	Halothane	43-52	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	58-62
10940303-0	2000	Binding of the general anesthetics propofol and halothane to human serum albumin.	Halothane	48-57	albumin	Homo sapiens	67-80
11465560-8	2001	Exposure to 20 microM Xestospongin D, a cell-permeant IP3 receptor antagonist, resulted in a 45+/-13% decrease in the [Ca2+]i response to halothane compared with halothane exposure alone.	Halothane	138-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-66
11465560-12	2001	CONCLUSIONS: The authors conclude that halothane reduces sarcoplasmic reticulum Ca2+ content in ASM cells via increased Ca2+ leak through both IP3 receptor and ryanodine receptor channels.	Halothane	39-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-155
11205598-4	2001	The measured halothane concentration was corrected to sea level.	Halothane	13-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	54-57
11506125-3	2001	The aim of the current study was to examine the effect of halothane on the IL-1beta-evoked induction of NOS in vascular smooth muscle.	Halothane	58-67	interleukin 1 beta	Rattus norvegicus	75-83
11506125-5	2001	The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied.	Halothane	15-24	interleukin 1 beta	Rattus norvegicus	60-68
11393269-1	2001	Cytochrome P450 2A6 is an important human hepatic P450 which activates precarcinogens and oxidizes some drug constituents such as coumarin, halothane, and the major nicotine C-oxidase.	Halothane	140-149	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-19
11299326-7	2001	Also, the high-affinity choline uptake (HACU) in hippocampal synaptosomes from awake hAChE-Tg mice was accelerated but was reduced by halothane anaesthesia.	Halothane	134-143	high affinity choline uptake	Mus musculus	40-44
11283227-1	2001	We examined the influence of two clinically relevant concentrations (1 and 2 MAC (minimum alveolar concentration)) of halothane and sevoflurane on both efflux and reverse modes of Na+-Ca2+ exchange (NCX) in enzymatically dissociated adult rat cardiac myocytes.	Halothane	118-127	solute carrier family 8 member A1	Rattus norvegicus	199-202
11283227-7	2001	Compared to controls, both 1 and 2 MAC halothane as well as sevoflurane reduced NCX-mediated efflux.	Halothane	39-48	solute carrier family 8 member A1	Rattus norvegicus	80-83
11060316-1	2001	Two cDNAs encoding novel K(+) channels, THIK-1 and THIK-2 (tandem pore domain halothane inhibited K(+) channel), were isolated from rat brain.	Halothane	78-87	potassium two pore domain channel subfamily K member 13	Rattus norvegicus	40-46
11060316-1	2001	Two cDNAs encoding novel K(+) channels, THIK-1 and THIK-2 (tandem pore domain halothane inhibited K(+) channel), were isolated from rat brain.	Halothane	78-87	potassium two pore domain channel subfamily K member 12	Rattus norvegicus	51-57
11157886-0	2001	Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration.	Halothane	21-30	rhodopsin	Rattus norvegicus	91-100
11157886-6	2001	RESULTS: Halothane anesthesia reversibly inhibited metabolic rhodopsin regeneration and thus prevented rhodopsin from absorbing high numbers of photons during light exposure.	Halothane	9-18	rhodopsin	Rattus norvegicus	61-70
11157886-6	2001	RESULTS: Halothane anesthesia reversibly inhibited metabolic rhodopsin regeneration and thus prevented rhodopsin from absorbing high numbers of photons during light exposure.	Halothane	9-18	rhodopsin	Rattus norvegicus	103-112
11157886-9	2001	CONCLUSIONS: After the initial bleach, halothane impeded photon absorption by rhodopsin by inhibiting metabolic rhodopsin regeneration.	Halothane	39-48	rhodopsin	Rattus norvegicus	78-87
11157886-9	2001	CONCLUSIONS: After the initial bleach, halothane impeded photon absorption by rhodopsin by inhibiting metabolic rhodopsin regeneration.	Halothane	39-48	rhodopsin	Rattus norvegicus	112-121
11135732-2	2001	The authors tested the hypothesis that halothane reduces rMLC phosphorylation during muscarinic stimulation at constant intracellular [Ca(2+)] by increasing smooth muscle protein phosphatase (SMPP) activity, without changing myosin light-chain kinase (MLCK) activity.	Halothane	39-48	myosin light chain kinase	Canis lupus familiaris	252-256
11112152-9	2000	Indeed, when using 1% halothane, polymorphonuclear leukocyte (PMN) recruitment was decreased by 55% (p < 0.001) and TNF-alpha, IL-6, and MIP-2 concentrations in BALF and lung homogenates were decreased by more than 60% (p < 0.001) whereas total protein and MCP-1 concentrations remained unchanged.	Halothane	22-31	tumor necrosis factor	Rattus norvegicus	119-128
11112152-9	2000	Indeed, when using 1% halothane, polymorphonuclear leukocyte (PMN) recruitment was decreased by 55% (p < 0.001) and TNF-alpha, IL-6, and MIP-2 concentrations in BALF and lung homogenates were decreased by more than 60% (p < 0.001) whereas total protein and MCP-1 concentrations remained unchanged.	Halothane	22-31	C-X-C motif chemokine ligand 2	Rattus norvegicus	140-145
11112152-9	2000	Indeed, when using 1% halothane, polymorphonuclear leukocyte (PMN) recruitment was decreased by 55% (p < 0.001) and TNF-alpha, IL-6, and MIP-2 concentrations in BALF and lung homogenates were decreased by more than 60% (p < 0.001) whereas total protein and MCP-1 concentrations remained unchanged.	Halothane	22-31	C-C motif chemokine ligand 2	Rattus norvegicus	263-268
11063987-3	2000	Under normoxic conditions, intrastriatal stereotaxic injection of exogenous ET-1 (40 pmol) induced a significant (P<0.05) reduction (</=29+/-12%) in the regional (striatal) cerebral blood flow measured by Laser Doppler flowmetry (CBF(LDF)) for up to 40 min in halothane-anesthetized male Long-Evans rats.	Halothane	266-275	endothelin 1	Rattus norvegicus	76-80
11046221-3	2000	Here the authors describe changes in myosin isoform expression in the hearts of MH-susceptible pigs with and without prior exposure to halothane.	Halothane	135-144	myosin X	Sus scrofa	37-43
11046221-8	2000	RESULTS: Malignant hyperthermia-susceptible animals with the prior halothane challenge showed an increased V1 myosin (-44%) expression, increased myofibrillar ATPase activity (-25%) and increased steepness of the Ca2+-ATPase activity relation.	Halothane	67-76	myosin X	Sus scrofa	110-116
11101209-0	2000	Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane.	Halothane	167-176	fibroblast growth factor 2	Homo sapiens	20-25
11004044-8	2000	LPS enhanced halothane-induced 3.9 and 1.6-fold increases in rCBF at 1.0 and 1.5 minimum alveolar concentration, respectively.	Halothane	13-22	CCAAT/enhancer binding protein zeta	Rattus norvegicus	61-65
11004044-9	2000	Co-treatment with NS-398 attenuated, but aminoguanidine or dexamethasone abolished the effect of LPS on halothane-induced rCBF increase.	Halothane	104-113	CCAAT/enhancer binding protein zeta	Rattus norvegicus	122-126
11004044-10	2000	Diethylamine NONOate mimicked the enhanced rCBF response to halothane.	Halothane	60-69	CCAAT/enhancer binding protein zeta	Rattus norvegicus	43-47
11004044-11	2000	These results suggest that LPS augmented halothane-induced cerebrocortical hyperemia by induction of iNOS and COX-2.	Halothane	41-50	nitric oxide synthase 2	Homo sapiens	101-105
11004044-11	2000	These results suggest that LPS augmented halothane-induced cerebrocortical hyperemia by induction of iNOS and COX-2.	Halothane	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
10905576-9	2000	Grip score after the trauma was better in mice anesthetized with halothane at either 2% or 4%.	Halothane	65-74	glutamate receptor interacting protein 1	Mus musculus	0-4
11732530-0	2000	Sex and oestrous cycle differences in visceromotor responses and vasopressin release in response to colonic distension in male and female rats anaesthetized with halothane.	Halothane	162-171	arginine vasopressin	Rattus norvegicus	65-76
10880510-12	2000	As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.	Halothane	82-91	potassium two pore domain channel subfamily K member 2	Homo sapiens	8-13
10880510-12	2000	As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.	Halothane	82-91	potassium two pore domain channel subfamily K member 10	Homo sapiens	15-20
10956261-2	2000	The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats.	Halothane	220-229	angiotensinogen	Rattus norvegicus	69-75
10956261-2	2000	The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats.	Halothane	220-229	angiotensinogen	Rattus norvegicus	93-99
10956261-2	2000	The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats.	Halothane	220-229	angiotensinogen	Rattus norvegicus	93-99
10947757-8	2000	Pre-incisionally, IL-2 increased in the halothane group (p<0.01), whereas it decreased significantly in the isoflurane group (p<0.001) compared with the pre-induction level.	Halothane	40-49	interleukin 2	Homo sapiens	18-22
10947757-9	2000	By the end of anaesthesia and surgery and by 24 h postoperatively, IL-2 had decreased significantly in the halothane group (p<0.001), whereas it increased significantly in the isoflurane group (p<0.001) compared with pre-incision and end of anaesthesia and surgery levels, respectively.	Halothane	107-116	interleukin 2	Homo sapiens	67-71
10969314-4	2000	Our goal was to evaluate the effects of halothane and thiopental on SP-C messenger RNA (mRNA) expression in vitro in rat alveolar type II cells and in vivo in mechanically ventilated rats.	Halothane	40-49	surfactant protein C	Rattus norvegicus	68-72
10969314-8	2000	In alveolar type II cells exposed for 4 h to halothane 1, 2, and 4%, the SP-C mRNA content increased dose-dependently to 160, 235, and 275%, respectively, of the control values.	Halothane	45-54	surfactant protein C	Rattus norvegicus	73-77
10969314-9	2000	In vivo, in mechanically ventilated rats, 4 h of halothane anesthesia decreased the lung SP-C mRNA content to 53% of the value obtained in control (nonanesthetized, nonventilated) animals; thiopental anesthesia increased to 150% the lung SP-C mRNA content.	Halothane	49-58	surfactant protein C	Rattus norvegicus	89-93
10969314-9	2000	In vivo, in mechanically ventilated rats, 4 h of halothane anesthesia decreased the lung SP-C mRNA content to 53% of the value obtained in control (nonanesthetized, nonventilated) animals; thiopental anesthesia increased to 150% the lung SP-C mRNA content.	Halothane	49-58	surfactant protein C	Rattus norvegicus	238-242
10969314-10	2000	CONCLUSIONS: These findings indicate that halothane and thiopental used at clinically relevant concentrations modulate the pulmonary SP-C mRNA content in rats.	Halothane	42-51	surfactant protein C	Rattus norvegicus	133-137
10997577-1	2000	We examined effects of gap junction blockers, octanol and halothane, on circadian rhythms in the release of arginine-vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) in suprachiasmatic nucleus (SCN) slice cultures of the rat.	Halothane	58-67	arginine vasopressin	Rattus norvegicus	108-128
10997577-1	2000	We examined effects of gap junction blockers, octanol and halothane, on circadian rhythms in the release of arginine-vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) in suprachiasmatic nucleus (SCN) slice cultures of the rat.	Halothane	58-67	arginine vasopressin	Rattus norvegicus	130-133
10997577-1	2000	We examined effects of gap junction blockers, octanol and halothane, on circadian rhythms in the release of arginine-vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) in suprachiasmatic nucleus (SCN) slice cultures of the rat.	Halothane	58-67	vasoactive intestinal peptide	Rattus norvegicus	139-172
10952666-1	2000	The modulatory effect of protein kinase C (PKC) on the response of Xenopus oocyte-expressed Na channel alpha-subunits to halothane (2-bromo-2-chloro-1,1,1-trifluroethane) was studied.	Halothane	121-130	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	92-102
10952666-10	2000	We conclude that the halothane suppresses skeletal muscle and brain Na channel activity in this preparation through a reduction in the slow mode of inactivation gating, but only after PKC co-expression.	Halothane	21-30	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	68-78
10992823-3	2000	Although serum mAST activities increased after surgery in both groups of patients, these increases were statistically significantly greater in the group that received halothane.	Halothane	167-176	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	15-19
10922470-1	2000	The mutation of a single leucine residue (L38) to methionine (M) is known experimentally to significantly increase the affinity of the synthetic four-alpha-helix bundle (Aalpha(2))(2) for the anesthetic halothane.	Halothane	203-212	ribosomal protein L38	Homo sapiens	42-45
10913255-0	2000	Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling.	Halothane	0-9	C-X-C motif chemokine receptor 6	Homo sapiens	23-49
10913255-2	2000	To determine whether these effects might be mediated by direct binding interactions with the GPCR or its associated G protein, we studied the binding character of halothane on mammalian rhodopsin, structurally the best understood GPCR, by using direct photoaffinity labeling with [(14)C]halothane.	Halothane	163-172	C-X-C motif chemokine receptor 6	Homo sapiens	93-97
10913255-2	2000	To determine whether these effects might be mediated by direct binding interactions with the GPCR or its associated G protein, we studied the binding character of halothane on mammalian rhodopsin, structurally the best understood GPCR, by using direct photoaffinity labeling with [(14)C]halothane.	Halothane	163-172	rhodopsin	Homo sapiens	186-195
10913255-10	2000	The absence of halothane binding to any of the G protein subunits strongly suggests that the functional effects of halothane on GPCR signaling systems are mediated by direct interactions with receptor proteins.	Halothane	115-124	C-X-C motif chemokine receptor 6	Homo sapiens	128-132
10861165-12	2000	This increase in caspase-9 activity was blocked by isoflurane at 1.6 MAC and halothane at 1.2 MAC.	Halothane	77-86	caspase 9	Rattus norvegicus	17-26
10930210-8	2000	Sustained noxious stimulation to the hindpaw in halothane-anesthetized animals was associated with an increase in c-fos immunoreactivity in the dorsal horn of the lumbar spinal cord ipsilateral to the stimulation (P < 0.001).	Halothane	48-57	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-119
10850971-2	2000	In the present study, we demonstrate, using dual whole-cell voltage-clamp techniques, that coexpression of connexin (Cx) 40 and Cx43 rendered cells more sensitive to uncoupling by halothane than cells that express only Cx40 or only Cx43.	Halothane	180-189	gap junction protein alpha 1	Homo sapiens	128-132
10850971-4	2000	The magnitude of the effect of halothane on channel open time was least for Cx40-like channels and greatest for heteromeric channels.	Halothane	31-40	gap junction protein alpha 5	Homo sapiens	76-80
10839927-0	2000	Halothane and isoflurane augment depolarization-induced cytosolic CA2+ transients and attenuate carbachol-stimulated CA2+ transients.	Halothane	0-9	carbonic anhydrase 2	Homo sapiens	66-69
10839927-0	2000	Halothane and isoflurane augment depolarization-induced cytosolic CA2+ transients and attenuate carbachol-stimulated CA2+ transients.	Halothane	0-9	carbonic anhydrase 2	Homo sapiens	117-120
10839927-7	2000	RESULTS: Halothane and isoflurane in clinically relevant concentrations enhanced the K+-evoked [Ca2+]cyt transient whether intracellular Ca2+ stores were full or partially depleted.	Halothane	9-18	carbonic anhydrase 2	Homo sapiens	96-99
10839927-7	2000	RESULTS: Halothane and isoflurane in clinically relevant concentrations enhanced the K+-evoked [Ca2+]cyt transient whether intracellular Ca2+ stores were full or partially depleted.	Halothane	9-18	carbonic anhydrase 2	Homo sapiens	137-140
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Halothane	13-22	carbonic anhydrase 2	Homo sapiens	68-71
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Halothane	13-22	carbonic anhydrase 2	Homo sapiens	110-113
10894495-6	2000	Also, mice inhaling halothane had significantly decreased activities of pro-inflammatory cytokines interleukin 6 and tumor necrosis factor-alpha in lung homogenates at 24 hours after inoculation, compared with those given pentobarbital IP.	Halothane	20-29	interleukin 6	Mus musculus	99-144
10814537-3	2000	Using electrophoretic separation following incubation with halothane, increases in relative molecular mass were determined by immunoblotting with a monoclonal antibody to the SERCA1 isoform of the Ca(2+)-ATPase.	Halothane	59-68	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	175-181
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Halothane	13-22	carbonic anhydrase 2	Homo sapiens	110-113
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Halothane	183-192	carbonic anhydrase 2	Homo sapiens	55-58
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Halothane	183-192	carbonic anhydrase 2	Homo sapiens	102-105
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Halothane	183-192	carbonic anhydrase 2	Homo sapiens	102-105
10794813-7	2000	The IC(50) values of the volatile anesthetics, halothane, sevoflurane, enflurane, and isoflurane for hIK1 inhibition were 0.69, 0.42, 1.01 and 1.03 mM, respectively, and were in the clinically used concentration range.	Halothane	47-56	potassium calcium-activated channel subfamily N member 4	Homo sapiens	101-105
10794813-8	2000	In contrast to BK channel, halothane inhibition of hIK1 currents was independent of Ca(2+) concentration, suggesting that Ca(2+) gating mechanism is not involved.	Halothane	27-36	potassium calcium-activated channel subfamily N member 4	Homo sapiens	51-55
10754630-4	2000	METHODS: Nitrite release and iNOS expression were determined using the Griess reaction and Western and Northern blot techniques, respectively, in J774 murine macrophages stimulated with lipopolysaccharide and gamma-interferon in the absence and presence of various concentrations (0.25-2.0 minimum alveolar concentration [MAC]) of volatile anesthetics (i.e., halothane, enflurane, isoflurane, desflurane).	Halothane	359-368	interferon gamma	Mus musculus	209-225
10718346-9	2000	Our findings in this study thus indicate that halothane-induced hepatotoxicity is due not only to its reductive metabolite formation, but also to an increase in hepatic free heme concentration, which is a potent prooxidant; HO-1 induction is an important protective response against such changes.	Halothane	46-55	heme oxygenase 1	Rattus norvegicus	224-228
10718346-10	2000	This is also the first study to demonstrate that hemin pretreatment, which induces HO-1 prior to exposure to halothane, effectively prevents halothane-induced hepatotoxicity.	Halothane	141-150	heme oxygenase 1	Rattus norvegicus	83-87
11307469-6	2000	In comparison with other classes of material, Ketac Endo was the least soluble in chloroform and halothane (P < 0.01), with less than 1% weight loss after 10 min exposure to either solvent.	Halothane	97-106	mannosidase endo-alpha	Homo sapiens	52-56
10638908-8	2000	Inhibition of nNOS by 7-NINA or nNOS + eNOS by L-NAME similarly attenuated halothane-induced dilation at 0.6, 1.6, and 2.6% halothane.	Halothane	75-84	nitric oxide synthase 1	Rattus norvegicus	14-18
10638908-8	2000	Inhibition of nNOS by 7-NINA or nNOS + eNOS by L-NAME similarly attenuated halothane-induced dilation at 0.6, 1.6, and 2.6% halothane.	Halothane	75-84	nitric oxide synthase 1	Rattus norvegicus	32-36
10638908-8	2000	Inhibition of nNOS by 7-NINA or nNOS + eNOS by L-NAME similarly attenuated halothane-induced dilation at 0.6, 1.6, and 2.6% halothane.	Halothane	75-84	nitric oxide synthase 3	Rattus norvegicus	39-43
10638908-8	2000	Inhibition of nNOS by 7-NINA or nNOS + eNOS by L-NAME similarly attenuated halothane-induced dilation at 0.6, 1.6, and 2.6% halothane.	Halothane	124-133	nitric oxide synthase 1	Rattus norvegicus	14-18
10638913-4	2000	METHODS: Washed platelets were stimulated by thrombin after incubation with 0.5, 1.0, or 1.5 mM sevoflurane, halothane, or isoflurane.	Halothane	109-118	coagulation factor II, thrombin	Homo sapiens	45-53
10674505-3	2000	Our aim was to compare the rate of change of CBFV when end-tidal CO2 (P(ET)CO2) was rapidly altered during halothane or isoflurane anesthesia.	Halothane	107-116	complement C2	Homo sapiens	70-78
10674505-8	2000	In all patients anesthetized with isoflurane, and in all but two patients anesthetized with halothane, the reduction in P(ET)CO2 produced a corresponding decrease in CBFV However, there were no differences in the magnitude of cerebrovascular CO2 reactivity (delta CBFV vs. delta P(ET)CO2) between the two groups.	Halothane	92-101	complement C2	Homo sapiens	120-128
10805064-1	2000	OBJECTIVE: Halothane undergoes both oxidative and reductive metabolism by cytochrome P450 (CYP), respectively causing rare immune-mediated hepatic necrosis and common, mild subclinical hepatic toxicity.	Halothane	11-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	74-89
10805064-1	2000	OBJECTIVE: Halothane undergoes both oxidative and reductive metabolism by cytochrome P450 (CYP), respectively causing rare immune-mediated hepatic necrosis and common, mild subclinical hepatic toxicity.	Halothane	11-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	91-94
10805064-4	2000	The mechanism-based CYP2E1 inhibitor disulfiram diminished human halothane oxidation in vivo.	Halothane	65-74	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	20-26
10805064-5	2000	This investigation tested the hypotheses that halothane causes lipid peroxidation in humans in vivo, and that CYP2A6 or CYP3A4 inhibition can diminish halothane metabolism.	Halothane	151-160	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	110-116
10805064-5	2000	This investigation tested the hypotheses that halothane causes lipid peroxidation in humans in vivo, and that CYP2A6 or CYP3A4 inhibition can diminish halothane metabolism.	Halothane	151-160	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	120-126
10805064-15	2000	CYP2A6-mediated, like CYP2E1-mediated human halothane oxidation, can be inhibited in vivo by mechanism-based CYP inhibitors.	Halothane	44-53	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
10805064-15	2000	CYP2A6-mediated, like CYP2E1-mediated human halothane oxidation, can be inhibited in vivo by mechanism-based CYP inhibitors.	Halothane	44-53	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	22-28
10805064-15	2000	CYP2A6-mediated, like CYP2E1-mediated human halothane oxidation, can be inhibited in vivo by mechanism-based CYP inhibitors.	Halothane	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
10623902-6	2000	Only the mushroom body defect (mud) line showed an increased sensitivity of the escape response to halothane.	Halothane	99-108	mushroom body defect	Drosophila melanogaster	31-34
10623902-10	2000	Although we do not yet know whether the mud gene encodes an anesthetic target or influences the functioning of an anesthetic-sensitive neuron in this pathway, our work indicates that this gene regulates the effects of halothane on a circumscribed pathway.	Halothane	218-227	mushroom body defect	Drosophila melanogaster	40-43
10937864-3	1999	I found that halothane did not alter Ca2+ binding to cardiac troponin C. However, halothane and isoflurane reversibly decreased the Ca2+ affinity of calmodulin at low anesthetic concentration, and irreversibly increased the Ca2+ affinity of calmodulin at high anesthetic concentration.	Halothane	82-91	calmodulin 1	Homo sapiens	149-159
10937864-3	1999	I found that halothane did not alter Ca2+ binding to cardiac troponin C. However, halothane and isoflurane reversibly decreased the Ca2+ affinity of calmodulin at low anesthetic concentration, and irreversibly increased the Ca2+ affinity of calmodulin at high anesthetic concentration.	Halothane	82-91	calmodulin 1	Homo sapiens	241-251
10643591-3	1999	In support of this protein theory of anaesthetic action our native gel analysis presented here shows that halothane induces oligomerization of the skeletal muscle ryanodine receptor (RyR) 1 Ca(2+)-release channel, but not its cardiac RyR-2 isoform.	Halothane	106-115	ryanodine receptor 2	Homo sapiens	234-239
10626725-0	2000	Halothane facilitates the translocation of GRK-2 and phosphorylation of beta2-adrenergic receptor in rat synaptosomes.	Halothane	0-9	G protein-coupled receptor kinase 2	Rattus norvegicus	43-48
10626725-0	2000	Halothane facilitates the translocation of GRK-2 and phosphorylation of beta2-adrenergic receptor in rat synaptosomes.	Halothane	0-9	adrenoceptor beta 2	Rattus norvegicus	72-97
10626725-1	2000	PURPOSE: To examine the effect of halothane on beta2-adrenergic receptor phosphorylation and on G-protein coupled receptor kinase (GRK), responsible for beta2-receptor downregulation.	Halothane	34-43	adrenoceptor beta 2	Rattus norvegicus	47-72
10626725-9	2000	The concentration of GRK-2 decreased in the cytosol obtained from synaptosomes exposed to halothane 1% or 2% (decreases of 8.3+/-1.2% @ 1%, and 18.0+/-2.1% @ 2%, P<0.05).	Halothane	90-99	G protein-coupled receptor kinase 2	Rattus norvegicus	21-26
10626725-10	2000	In the membrane, exposure to halothane 1% or 2% increased the GRK-2 amount dose dependently (22.5+/-3.1% @ 1%, and by 45.7+/-6.1% @ 2%, P<0.01).	Halothane	29-38	G protein-coupled receptor kinase 2	Rattus norvegicus	62-67
10626725-11	2000	CONCLUSION: Halothane could facilitate translocation of GRK-2 and possibly promote the downregulation of beta2-adrenergic receptors in the synaptic membrane.	Halothane	12-21	G protein-coupled receptor kinase 2	Rattus norvegicus	56-61
10611444-2	1999	At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to suppress GDPbetaS release.	Halothane	25-34	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	121-127
10560840-4	1999	In this study, a halothane test used with swine was evaluated as a possible detection method for PSE-susceptible turkeys.	Halothane	17-26	PSE	Sus scrofa	97-100
10551274-0	1999	5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients.	Halothane	49-58	5-hydroxytryptamine receptor 2A	Homo sapiens	0-14
10510277-1	1999	Cytochrome P450 (CYP) 2A6 is the principal human enzyme catalyzing coumarin 7-hydroxylation and is known to be involved in the metabolism of halothane, nicotine, and metabolic activation of butadiene and nitrosamines.	Halothane	141-150	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-25
10512286-3	1999	We examined the effects of 7-nitro indazole (7-NI), a selective neuronal NOS (nNOS) inhibitor, on halothane MAC.	Halothane	98-107	nitric oxide synthase 1	Rattus norvegicus	78-82
10512287-0	1999	Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats.	Halothane	0-9	carbonic anhydrase 1	Rattus norvegicus	142-145
10512287-9	1999	We conclude that clinically relevant concentrations of halothane depress synaptic transmission at Schaffer collateral-CA1 synapses and that the nonimmobilizers 2N and perfluoropentane have no effect or are excitatory.	Halothane	55-64	carbonic anhydrase 1	Rattus norvegicus	118-121
10512287-11	1999	IMPLICATIONS: Halothane, but not the nonimmobilizers 1,2-dichlorohexafluorocyclobutane and perfluoropentane, inhibits hippocampal synaptic transmission at Schaffer collateral-CA1 synapses.	Halothane	14-23	carbonic anhydrase 1	Rattus norvegicus	175-178
10626036-0	1999	Phenotyping of porcine apolipoprotein E using isoelectric focusing and localization of the APOE gene within the halothane-susceptibility linkage group.	Halothane	112-121	apolipoprotein E	Sus scrofa	91-95
10643591-6	1999	In addition, similar mutations in the RyR-2 isoform, which would trigger an episode of malignant hyperthermia in skeletal muscle fibres via abnormal RyR-1 isoforms, would probably not induce an increase in cardiac Ca(2+)-release upon administration of halothane.	Halothane	252-261	ryanodine receptor 2	Homo sapiens	38-43
10513171-0	1999	[The study of the anesthetic action of halothane on the rat spinal cord by fos immunoreactivity].	Halothane	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-78
10513171-1	1999	This study was performed to examine the anesthetic action of halothane on the spinal cord of rats by using fos immunoreactivity, a marker for neuronal activity following noxious stimulation.	Halothane	61-70	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-110
10513171-9	1999	The number of fos immunoreactive cells decreased in the cord of rats that showed no response to noxious stimulation by halothane 1 or 1.5 MAC.	Halothane	119-128	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
10439771-6	1999	We demonstrated in vitro that 1) a Na+H+ antiporter (apparent Km 6.8 +/- 3.4 mM, Vmax 0.0105 +/- 0.0013 delta UpHi/s) regulates the pHi of SV40-T2 cells and 2) at clinically relevant concentrations (10(-3) to 10(-5) M) and for a short exposure duration (60 min), halothane enhances the activity of this antiporter.	Halothane	263-272	glucose-6-phosphate isomerase	Rattus norvegicus	111-114
10051189-2	1999	In the present report, changes in the intracellular Ca2+ concentration in the hippocampal CA1 area during transient global ischemia and reperfusion were measured using in vivo Ca2+ fluorometry with fura-2 in the four-vessel occlusion and reperfusion model in halothane-anesthetized rats.	Halothane	259-268	carbonic anhydrase 2	Rattus norvegicus	52-55
10319776-0	1999	ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine.	Halothane	62-71	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-3
10319776-7	1999	RESULTS: ATX II increased the magnitude of contracture to halothane in preparations from most MH-, but not MH+, human participants.	Halothane	58-67	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	9-12
10201687-6	1999	Single-dose experiments in CA1 neurons in hippocampal slices with halothane (360 microM) and in acutely dissociated CA1 neurons with halothane (360 microM) and isoflurane (445 microM) also were performed.	Halothane	133-142	carbonic anhydrase 1	Rattus norvegicus	116-119
10201687-11	1999	Halothane increased [Ca2+]i in dissociated CA1 neurons and CA1 neurons in hippocampal slices by approximately 30 nM (P < 0.05).	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	21-24
10201687-11	1999	Halothane increased [Ca2+]i in dissociated CA1 neurons and CA1 neurons in hippocampal slices by approximately 30 nM (P < 0.05).	Halothane	0-9	carbonic anhydrase 1	Rattus norvegicus	43-46
10201687-12	1999	CONCLUSIONS: (1) Isoflurane and halothane reversibly increase [Ca2+]i in isolated neurons and in neurons within brain slices.	Halothane	32-41	carbonic anhydrase 2	Rattus norvegicus	63-66
10229494-0	1999	Influence of halothane on phospholipase A2 and enzymatic methylations in the rat retinal membranes.	Halothane	13-22	phospholipase A2 group IB	Rattus norvegicus	26-42
10229494-4	1999	Therefore, we have investigated the effect of halothane on retinal PLA2 activity.	Halothane	46-55	phospholipase A2 group IB	Rattus norvegicus	67-71
10097181-5	1999	The response of the mutant RyR1 Ca2+ channel to the agonists halothane and caffeine in a Ca2+ photometry assay was completely abolished.	Halothane	61-70	ryanodine receptor 1	Homo sapiens	27-30
10097181-6	1999	Coexpression of normal and mutant RYR1 cDNAs in a 1:1 ratio, however, produced RyR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca2+ release were reduced by 67%.	Halothane	105-114	ryanodine receptor 1	Homo sapiens	34-38
10051668-5	1999	By screening existing mutants of the nematode Caenorhabditis elegans, we found that a mutation in the neuronal syntaxin gene dominantly conferred resistance to the VAs isoflurane and halothane.	Halothane	183-192	t-SNARE coiled-coil homology domain-containing protein	Caenorhabditis elegans	111-119
10051668-9	1999	As assessed by pharmacological criteria, halothane and isoflurane themselves reduced cholinergic transmission, and the presynaptic anesthetic effect was blocked by the resistant syntaxin mutation.	Halothane	41-50	t-SNARE coiled-coil homology domain-containing protein	Caenorhabditis elegans	178-186
10078670-9	1999	Halothane reduced metabolism 40+/-9% to 3.7+/-0.6 mg x 100 g(-1) x min(-1) (P< or =0.005).	Halothane	0-9	CD59 molecule (CD59 blood group)	Homo sapiens	67-73
10082932-0	1999	Halothane, an inhalational anesthetic agent, increases folding stability of serum albumin.	Halothane	0-9	albumin	Homo sapiens	76-89
10082932-2	1999	We have used differential scanning calorimetry to study the effects of the anesthetic agent halothane on the thermally induced unfolding transition of bovine serum albumin.	Halothane	92-101	albumin	Homo sapiens	158-171
10082932-3	1999	We find that halothane (0.6-10 mM) stabilizes the folded state of this protein, increasing its transition midpoint temperature from 62 to 71 degrees C. Binding of halothane to the native state of serum albumin thus outweighs any non-specific interactions between the thermally unfolded state of serum albumin and halothane in this concentration range.	Halothane	13-22	albumin	Homo sapiens	196-209
10082932-3	1999	We find that halothane (0.6-10 mM) stabilizes the folded state of this protein, increasing its transition midpoint temperature from 62 to 71 degrees C. Binding of halothane to the native state of serum albumin thus outweighs any non-specific interactions between the thermally unfolded state of serum albumin and halothane in this concentration range.	Halothane	13-22	albumin	Homo sapiens	295-308
10082932-3	1999	We find that halothane (0.6-10 mM) stabilizes the folded state of this protein, increasing its transition midpoint temperature from 62 to 71 degrees C. Binding of halothane to the native state of serum albumin thus outweighs any non-specific interactions between the thermally unfolded state of serum albumin and halothane in this concentration range.	Halothane	163-172	albumin	Homo sapiens	196-209
10082932-3	1999	We find that halothane (0.6-10 mM) stabilizes the folded state of this protein, increasing its transition midpoint temperature from 62 to 71 degrees C. Binding of halothane to the native state of serum albumin thus outweighs any non-specific interactions between the thermally unfolded state of serum albumin and halothane in this concentration range.	Halothane	163-172	albumin	Homo sapiens	196-209
10082932-5	1999	Analysis of the dependence of DeltaDeltaG on halothane concentration shows that thermal unfolding of a bovine serum albumin molecule is linked to the dissociation of about one halothane molecule at lower halothane concentrations and about six at higher halothane concentrations.	Halothane	45-54	albumin	Homo sapiens	110-123
10082932-5	1999	Analysis of the dependence of DeltaDeltaG on halothane concentration shows that thermal unfolding of a bovine serum albumin molecule is linked to the dissociation of about one halothane molecule at lower halothane concentrations and about six at higher halothane concentrations.	Halothane	176-185	albumin	Homo sapiens	110-123
10082932-5	1999	Analysis of the dependence of DeltaDeltaG on halothane concentration shows that thermal unfolding of a bovine serum albumin molecule is linked to the dissociation of about one halothane molecule at lower halothane concentrations and about six at higher halothane concentrations.	Halothane	176-185	albumin	Homo sapiens	110-123
10082932-5	1999	Analysis of the dependence of DeltaDeltaG on halothane concentration shows that thermal unfolding of a bovine serum albumin molecule is linked to the dissociation of about one halothane molecule at lower halothane concentrations and about six at higher halothane concentrations.	Halothane	176-185	albumin	Homo sapiens	110-123
9873004-6	1999	When heterotetrameric (1:1) combinations of MH/CCD mutant and wild type RyR1 were expressed together with SERCA1 to enhance Ca2+ reuptake, the amplitude of Ca2+ release in response to low concentrations of caffeine and halothane was higher than that observed in cells expressing wild type RyR1 and SERCA1.	Halothane	219-228	ryanodine receptor 1	Homo sapiens	72-76
9873004-6	1999	When heterotetrameric (1:1) combinations of MH/CCD mutant and wild type RyR1 were expressed together with SERCA1 to enhance Ca2+ reuptake, the amplitude of Ca2+ release in response to low concentrations of caffeine and halothane was higher than that observed in cells expressing wild type RyR1 and SERCA1.	Halothane	219-228	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	106-112
14530945-3	1999	The anaerobic metabolism of HVA by CYP was followed by measuring the formation of a halothane CYP complex spectrophotometrically.	Halothane	84-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	35-38
14530945-3	1999	The anaerobic metabolism of HVA by CYP was followed by measuring the formation of a halothane CYP complex spectrophotometrically.	Halothane	84-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-97
14530945-5	1999	RESULTS: The formation of the halothane-CYP complex was dose-dependently inhibited by NO.	Halothane	30-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-43
14530945-6	1999	NO also decreased CYP defluorination of halothane in a dose-dependent manner.	Halothane	40-49	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
10360866-0	1999	Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels.	Halothane	11-20	H1.5 linker histone, cluster member	Homo sapiens	81-84
10360866-13	1999	CONCLUSIONS: In a heterologous expression system, halothane and isoflurane interact with the hH1a channels and suppress the sodium current.	Halothane	50-59	H1.1 linker histone, cluster member	Homo sapiens	93-97
10360868-10	1999	In Ore-R, the frequency of miniature excitatory junctional currents was decreased significantly in the presence of halothane (0.9-2.7%; 0.52-1.46 mM), whereas halothane did not change the frequency in two har mutants.	Halothane	115-124	narrow abdomen	Drosophila melanogaster	205-208
10321245-4	1999	Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK.	Halothane	27-36	potassium two pore domain channel subfamily K member 2	Homo sapiens	62-68
10229494-9	1999	These observations suggest that the release of retinal transmitters (dopamine, acetylcholine and others) is affected during halothane anesthesia, due to activation of PLA2 and enhanced fusogenic activity of vesicular membranes with plasma membrane and depletion of vesicles.	Halothane	124-133	phospholipase A2 group IB	Rattus norvegicus	167-171
10100670-1	1999	The objective of this study was to investigate the effects of the halothane (HAL) genotype, slaughter weight (SW), and the HAL x SW interaction on compositional and textural traits of raw and cooked pork.	Halothane	66-75	ryanodine receptor 1	Sus scrofa	77-80
9915333-2	1999	In the case of bovine serum albumin, the sites of halothane and chloroform binding have been identified as being located in the IB and IIA subdomains.	Halothane	50-59	albumin	Homo sapiens	22-35
10051189-2	1999	In the present report, changes in the intracellular Ca2+ concentration in the hippocampal CA1 area during transient global ischemia and reperfusion were measured using in vivo Ca2+ fluorometry with fura-2 in the four-vessel occlusion and reperfusion model in halothane-anesthetized rats.	Halothane	259-268	carbonic anhydrase 1	Rattus norvegicus	90-93
10211019-7	1998	Peak CKR to the coronary venous effluent was attenuated by all anaesthetics (halothane group 156 (45), enflurane group 134 (20), sevoflurane group 132 (20), desflurane group 159 (25) iu litre-1; each P < 0.05).	Halothane	77-86	choline kinase alpha	Rattus norvegicus	5-8
10049178-0	1998	Effects of halothane and supporting membrane lipids on the activity of acetylcholinesterase.	Halothane	11-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-91
10049178-2	1998	The activity of acetylcholinesterase in the human erythrocyte membrane was measured with and without halothane.	Halothane	101-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
10049182-1	1998	(1) We have investigated the effect of halothane on glutamate receptor-mediated excitation in pyramidal cells and interneurons of the hippocampal CA1 area.	Halothane	39-48	carbonic anhydrase 1	Homo sapiens	146-149
9804904-8	1998	The number of neurons labeled for PPD mRNA in the halothane group was significantly less than the control group.	Halothane	50-59	prodynorphin	Rattus norvegicus	34-37
9804904-9	1998	However, the number of PPD mRNA-expressing neurons in both the ketamine and nitrous oxide groups was significantly less than the halothane group.	Halothane	129-138	prodynorphin	Rattus norvegicus	23-26
9804904-11	1998	These data indicate that the suppressive effect of halothane anesthesia on the induction of PPD mRNA in dorsal horn neurons was smaller than those of ketamine and nitrous oxide, suggesting an important supplemental way to control the alteration of gene expression in spinal neurons for clinical settings.	Halothane	51-60	prodynorphin	Rattus norvegicus	92-95
9809083-1	1998	BACKGROUND: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1.	Halothane	12-21	cytochrome P450 2E1	Oryctolagus cuniculus	64-90
10417859-9	1998	The amplitude of MH muscle contracture with stepwise concentrations of halothane was correlated with the increase of RT1/2 and R, and the decrease of -dP/dtmax.	Halothane	71-80	nuclear receptor subfamily 6 group A member 1	Homo sapiens	117-128
9865851-5	1998	Corticosterone (CORT)-like immunoreactivities were significantly elevated by halothane in all experimental groups, and in the 2- and 24-h groups following methoxyflurane exposure.	Halothane	77-86	cortistatin	Rattus norvegicus	16-20
9743407-8	1998	This finding suggests that a mutation in FKBP12 or changes in its capacity to bind to the ryanodine receptor could alter the halothane sensitivity of the skeletal muscle ryanodine receptor and thereby predispose the person to malignant hyperthermia.	Halothane	125-134	ryanodine receptor 1	Homo sapiens	154-188
9697132-5	1998	Using retrograde tracing techniques combined with the immunohistochemical detection of: (i) the catecholamine synthetic enzyme, tyrosine hydroxylase and (ii) the protein product of the immediate-early gene c-fos as a marker of neuronal activation; the results of this study indicate that catecholaminergic projections from the A1, C1 and C2 regions of the medulla to the ventrolateral periaqueductal gray are activated by halothane anaesthesia.	Halothane	422-431	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	206-211
9710399-6	1998	RESULTS: Our results indicate that pretreating platelets with halothane leads to a partial impairment of the [Ca2+]i increase induced either by U46619, thrombin, or platelet-activating factor, but this had no significant effect on the [Ca2+]i response triggered by thapsigargin.	Halothane	62-71	coagulation factor II, thrombin	Homo sapiens	152-160
9743407-8	1998	This finding suggests that a mutation in FKBP12 or changes in its capacity to bind to the ryanodine receptor could alter the halothane sensitivity of the skeletal muscle ryanodine receptor and thereby predispose the person to malignant hyperthermia.	Halothane	125-134	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	41-47
9637655-0	1998	Halothane decreases Na,K-ATPase, and Na channel activity in alveolar type II cells.	Halothane	0-9	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	37-47
9705994-8	1998	Halothane, heptanol and octanol, which are commonly used as gap junction inhibitors, drastically reduced the amplitude of Et1-induced calcium responses.	Halothane	0-9	endothelin 1	Rattus norvegicus	122-125
9649409-1	1998	To understand further the weak molecular interactions between inhaled anesthetics and proteins, we studied the character and dynamic consequences of halothane binding to bovine serum albumin (BSA) and myoglobin using photoaffinity labeling and hydrogen-tritium exchange (HX).	Halothane	149-158	albumin	Homo sapiens	177-190
9649409-2	1998	We find that halothane binds saturably and with submillimolar affinity to BSA, but either nonspecifically or with considerably lower affinity to myoglobin.	Halothane	13-22	myoglobin	Homo sapiens	145-154
9649409-5	1998	Protection factors for slowly exchanging hydrogens in myoglobin are decreased by halothane, suggesting destabilization through binding to an intermediate or completely unfolded conformer.	Halothane	81-90	myoglobin	Homo sapiens	54-63
9637655-11	1998	Exposure for 45 min to 1% halothane also decreased Na channel activity by 46%.	Halothane	26-35	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	51-61
9637655-13	1998	CONCLUSIONS: Sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channel activities are impaired by halothane in alveolar type II cells in vitro.	Halothane	119-128	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	81-91
9669017-0	1998	Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.	Halothane	31-40	carbonic anhydrase 2	Rattus norvegicus	0-3
9669017-1	1998	PURPOSE: This study examined the direct myocardial depressant effect of halothane and determined whether an L-type Ca2+ channel agonist and antagonists altered the myocardial depression induced by halothane in cultured rat ventricular myocytes.	Halothane	197-206	carbonic anhydrase 2	Rattus norvegicus	115-118
9669017-4	1998	To assess the halothane-induced conformational changes in L-type Ca2+ channel, receptor binding study was performed using a dihydropyridine derivative, [3H] PN 200-110, in cardiac membrane preparation.	Halothane	14-23	carbonic anhydrase 2	Rattus norvegicus	65-68
9669017-7	1998	Bay K 8644, an L-type Ca2+ channel agonist, completely prevented the halothane-induced depression in amplitude (P < 0.05), but affected the beating rate less.	Halothane	69-78	carbonic anhydrase 2	Rattus norvegicus	22-25
9669017-9	1998	CONCLUSION: The reduction of Ca2+ current via sarcolemmal L-type Ca2+ channel, probably due to conformational changes in dihydropyridine binding sites, plays an important role in halothane-induced myocardial depression in living heart cells.	Halothane	179-188	carbonic anhydrase 2	Rattus norvegicus	29-32
9669017-9	1998	CONCLUSION: The reduction of Ca2+ current via sarcolemmal L-type Ca2+ channel, probably due to conformational changes in dihydropyridine binding sites, plays an important role in halothane-induced myocardial depression in living heart cells.	Halothane	179-188	carbonic anhydrase 2	Rattus norvegicus	65-68
9616199-0	1998	Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.	Halothane	6-15	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	38-57
9525931-4	1998	Results with chimeric receptors implicated a transmembrane region (TM4) of GluR6 in the action of halothane.	Halothane	98-107	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	75-80
28921248-4	1998	RESULTS: Halothane and sevoflurane produced significant (P<0.01) and dose-dependent inhibition of NO-stimulated sGC activity over a range of NO concentrations (2x10-9 to 2x10-5 M).	Halothane	9-18	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	115-118
28921248-5	1998	Among the anesthetics, halothane tended to have a large inhibitory effect on NO-stimulated sGC activity, which was, however, not significant.	Halothane	23-32	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	91-94
9626296-4	1998	METHODS: Regional cerebral blood flow (rCBF) was measured by laser-Doppler flowmetry in halothane-anesthetized, artificially ventilated rats for 4 hours after intracerebroventricular administration of LPS.	Halothane	88-97	CCAAT/enhancer binding protein zeta	Rattus norvegicus	39-43
9579518-4	1998	RESULTS: Studies with two-electrode voltage clamp at room temperature showed that halothane, isoflurane, and desflurane increased TOK1 outward currents by 48-65% in barium Frog Ringer"s perfusate.	Halothane	82-91	Tok1p	Saccharomyces cerevisiae S288C	130-134
9596344-4	1998	morphine on the extracellular level of CCK was analyzed in the spinal cord dorsal horn of halothane-anaesthetized normal rats as well as during peripheral neuropathy and inflammation.	Halothane	90-99	cholecystokinin	Rattus norvegicus	39-42
9523823-9	1998	CONCLUSIONS: The beta3 subunit of the GABA(A) receptor appears to be important in the mediation of the immobilizing (tail clamp) but not obtunding (loss-of-righting reflex) effects of the volatile anesthetic agents enflurane and halothane.	Halothane	229-238	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	17-22
9533708-0	1998	Spectroscopic analysis of halothane binding to the plasma membrane Ca2+-ATPase.	Halothane	26-35	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	51-78
9533708-1	1998	The intrinsic tryptophan (Trp) fluorescence of the plasma membrane Ca2+-ATPase (PMCA) is significantly quenched by halothane, a volatile anesthetic common in clinical practice.	Halothane	115-124	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	51-78
9602580-4	1998	With isoflurane, mean rate decreased from 72 (SD 9.7) to 67 (10.4) beat min-1 and with halothane from 76 (10.1) to 65 (9.1) beat min-1 (P < 0.05).	Halothane	87-96	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
9533708-1	1998	The intrinsic tryptophan (Trp) fluorescence of the plasma membrane Ca2+-ATPase (PMCA) is significantly quenched by halothane, a volatile anesthetic common in clinical practice.	Halothane	115-124	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	80-84
9533708-3	1998	We have investigated whether the observed quenching reflects halothane binding to PMCA.	Halothane	61-70	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	82-86
9533708-5	1998	The relatively low sensitivity of halothane quenching of Trp fluorescence to the concentration of phosphatidylcholine and detergent in the PMCA preparation concurs with the quenching resulting from anesthetic binding in the PMCA molecule.	Halothane	34-43	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	139-143
9533708-5	1998	The relatively low sensitivity of halothane quenching of Trp fluorescence to the concentration of phosphatidylcholine and detergent in the PMCA preparation concurs with the quenching resulting from anesthetic binding in the PMCA molecule.	Halothane	34-43	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	224-228
9533708-8	1998	These observations indicate that halothane quenching of intrinsic Trp fluorescence of PMCA results from anesthetic binding to the protein.	Halothane	33-42	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	86-90
9447865-3	1998	In this study, the authors investigated the possible role of G proteins and protein kinase C in the effects of halothane and isoflurane in the absence and presence of alpha1-adrenergic stimulation on the cardiac INa.	Halothane	111-120	Prkca	Cavia porcellus	76-92
9447865-11	1998	The positive interaction between methoxamine and halothane was evident in the presence of G protein and PKC inhibitors.	Halothane	49-58	Prkca	Cavia porcellus	104-107
9447865-17	1998	The positive interaction between methoxamine and anesthetics are independent of G proteins and PKC for halothane.	Halothane	103-112	Prkca	Cavia porcellus	95-98
9342941-4	1997	By the treatment of halothane, delayed type hypersensitivity (DTH) and mitogen (ConA, LPS) induced proliferation of splenocytes were significantly increased and suppressor cell activity and mixed lymphocyte reaction (MLR) were decreased in C57BL/6 mice.	Halothane	20-29	toll-like receptor 4	Mus musculus	86-89
9443943-4	1998	Halothane, F3, and ethanol inhibited mGluR5-induced Ca(2+)-dependent Cl- currents, yet pharmacologically relevant concentrations of these compounds had little effect on the glutamate-induced currents in the oocytes expressing mGluR1.	Halothane	0-9	glutamate receptor, ionotropic, kainate 1	Mus musculus	37-43
9443943-7	1998	GF109203X abolished the inhibitory effects of halothane, F3, and ethanol on mGluR5s.	Halothane	46-55	glutamate receptor, ionotropic, kainate 1	Mus musculus	76-82
9443943-9	1998	Furthermore, mutation of a PKC consensus site (Ser890) of mGluR5 abolished the inhibitory effects of halothane, F3, and ethanol.	Halothane	101-110	glutamate receptor, ionotropic, kainate 1	Mus musculus	58-64
9438519-0	1997	Cytochrome P-4502E1-dependent formation of trifluoroacetyl adducts from halothane by transduced HepG2 cells.	Halothane	72-81	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-19
9397032-6	1997	Application of adenosine at various depths in neocortex of halothane-anesthetized rats showed a predominant CBF increase at the level of application.	Halothane	59-68	CCAAT/enhancer binding protein zeta	Rattus norvegicus	108-111
9669211-6	1997	In vitro studies on spleen cell composition showed that halothane re-exposure diminished the number of CD4+, CD8+ and B-cells.	Halothane	56-65	CD4 antigen	Mus musculus	103-106
9335606-1	1997	We describe a genetic and behavioral analysis of several alleles of har38, a mutant with altered sensitivity to the general anesthetic halothane.	Halothane	135-144	narrow abdomen	Drosophila melanogaster	68-73
9342942-3	1997	Brazilin decreased splenic cellularity and IL-2 production which had been augmented in mice treated with halothane (21.5% in olive oil, 10 mmol/kg) for 4 consecutive days whereas the reduced expression of IL-2 receptors by ConA or standard IL-2 was increased by brazilin treatment.	Halothane	105-114	interleukin 2	Mus musculus	43-47
9305567-7	1997	RESULTS: In the halothane group, SOD activities and MDA concentrations were increased compared with control and GSH-Px and CAT activities were decreased.	Halothane	16-25	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	33-36
9316965-10	1997	CONCLUSIONS: Halothane or sevoflurane anesthesia induces venular leukocyte rolling and adhesion: P-selectin upregulation plays a crucial role in leukocyte rolling and adhesion during sevoflurane anesthesia, whereas low-flow perfusion is likely to evoke ICAM-1-dependent leukocyte adhesion during halothane anesthesia.	Halothane	13-22	selectin P	Rattus norvegicus	97-107
9316965-10	1997	CONCLUSIONS: Halothane or sevoflurane anesthesia induces venular leukocyte rolling and adhesion: P-selectin upregulation plays a crucial role in leukocyte rolling and adhesion during sevoflurane anesthesia, whereas low-flow perfusion is likely to evoke ICAM-1-dependent leukocyte adhesion during halothane anesthesia.	Halothane	296-305	selectin P	Rattus norvegicus	97-107
9305567-7	1997	RESULTS: In the halothane group, SOD activities and MDA concentrations were increased compared with control and GSH-Px and CAT activities were decreased.	Halothane	16-25	catalase	Cavia porcellus	123-126
9305567-12	1997	CONCLUSION: Although halothane causes impairment in enzymatic antioxidant defence potential, due to lowered GSH-Px and CAT activity, and accelerates peroxidative reactions in the tissues affected, no subcellular damage occurred.	Halothane	21-30	catalase	Cavia porcellus	119-122
9212147-7	1997	These results suggest that general anesthesia obtained with HAL inhalation will affect the metabolism of drugs administered concomitantly when the drug is a substrate for CYP2E1.	Halothane	60-63	cytochrome P450 2E1	Oryctolagus cuniculus	171-177
9249529-1	1997	In this study, angiotensin II (250 fmol in 30 nl) was injected into the NTS of halothane-anesthetized male Sprague-Dawley rats before and after NTS injections of the substance P antagonist [Leu11, psi CH2NH-(10-11)]substance P (600 fmol in 60 nl).	Halothane	79-88	angiotensinogen	Rattus norvegicus	15-29
9212147-0	1997	Halothane inhalation inhibits the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits.	Halothane	0-9	cytochrome P450 2E1	Oryctolagus cuniculus	79-85
9202335-4	1997	), a specific and irreversible inhibitor of histidine decarboxylase, reduced the histamine release to <35% of the basal value at 1% halothane anesthesia in the AHy, and also decreased the anesthetic requirement for halothane, evaluated as the minimum alveolar concentration (MAC), by 26%.	Halothane	135-144	histidine decarboxylase	Rattus norvegicus	44-67
9212147-1	1997	We demonstrated the inhibitory effect of halothane (HAL) inhalation on the metabolism of chlorzoxazone (CZZ), a substrate for CYP2E1, in a bolus and a continuous injection study in rabbits receiving artificial ventilation.	Halothane	41-50	cytochrome P450 2E1	Oryctolagus cuniculus	126-132
9212147-1	1997	We demonstrated the inhibitory effect of halothane (HAL) inhalation on the metabolism of chlorzoxazone (CZZ), a substrate for CYP2E1, in a bolus and a continuous injection study in rabbits receiving artificial ventilation.	Halothane	52-55	cytochrome P450 2E1	Oryctolagus cuniculus	126-132
9202335-4	1997	), a specific and irreversible inhibitor of histidine decarboxylase, reduced the histamine release to <35% of the basal value at 1% halothane anesthesia in the AHy, and also decreased the anesthetic requirement for halothane, evaluated as the minimum alveolar concentration (MAC), by 26%.	Halothane	218-227	histidine decarboxylase	Rattus norvegicus	44-67
9103523-0	1997	Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.	Halothane	65-74	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-19
9057895-1	1997	This study was undertaken to investigate whether cholinesterase (ChE) inhibitor exerts cardiovascular collapse through non-cholinergic mechanism in halothane-anesthetized rabbits.	Halothane	148-157	cholinesterase	Oryctolagus cuniculus	49-63
9098575-1	1997	The effects of inhalation anesthetics, nitrous oxide (N2O) and halothane, on the expression of c-Fos protein evoked by formalin injection were studied in the spinal cord in the rat.	Halothane	63-72	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
9098575-8	1997	Both N2O and halothane suppressed the expression of c-Fos in the neck of the dorsal horn and ventral gray in a dose-dependent manner, but no effects were seen at the superficial layer or nucleus proprius.	Halothane	13-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
9098575-9	1997	Suppression of c-Fos expression was greater under N2O than halothane anesthesia.	Halothane	59-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
9087617-3	1997	Halothane-anesthetized eNOS knockout and wild-type mice were subjected to permanent MCA occlusion by intraluminal filament for 24 h. bFGF (100 microg x kg(-1) x h(-1)) was infused intravenously for 2 h, beginning 15 min after the onset of occlusion.	Halothane	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	23-27
9057895-1	1997	This study was undertaken to investigate whether cholinesterase (ChE) inhibitor exerts cardiovascular collapse through non-cholinergic mechanism in halothane-anesthetized rabbits.	Halothane	148-157	cholinesterase	Oryctolagus cuniculus	65-68
9037193-9	1997	The KI value agrees well with the concentration at which halothane half-maximally activates SERCA1.	Halothane	57-66	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	92-98
9037193-10	1997	SDS gel electrophoresis of labeled membranes indicates that 38-56% of [14C]halothane incorporates into SERCA1, and 38-53% in lipids.	Halothane	75-84	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	103-109
9037193-11	1997	Distribution of label among the three fragments produced by controlled tryptic digestion of SERCA1 suggests heterogeneous halothane binding presumably in discrete sites in the enzyme.	Halothane	122-131	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	92-98
9037193-12	1997	The results provide the first direct evidence that halothane binds to SERCA1.	Halothane	51-60	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	70-76
9068340-2	1997	We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol-12,13-dibutyrate ([3H]PDBu) binding and PKC immunoreactivity in intact rat cerebrocortical synaptosomes, a subcellular fraction that contains functional nerve terminals.	Halothane	34-43	protein kinase C, alpha	Rattus norvegicus	101-104
9068340-2	1997	We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol-12,13-dibutyrate ([3H]PDBu) binding and PKC immunoreactivity in intact rat cerebrocortical synaptosomes, a subcellular fraction that contains functional nerve terminals.	Halothane	34-43	protein kinase C, alpha	Rattus norvegicus	107-110
9068340-2	1997	We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol-12,13-dibutyrate ([3H]PDBu) binding and PKC immunoreactivity in intact rat cerebrocortical synaptosomes, a subcellular fraction that contains functional nerve terminals.	Halothane	34-43	protein kinase C, alpha	Rattus norvegicus	107-110
9068340-3	1997	Halothane alone (2.4 vol%) reduced membrane-associated (P < 0.05) and increased cytosol (P < 0.01) PKC activity, while phorbol-12-myristate, 13-acetate (PMA) 0.1 mumol litre-1, a metabolically stable activator of PKC, reduced membrane (P < 0.01) without altering cytosol PKC activity.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	105-108
9068340-3	1997	Halothane alone (2.4 vol%) reduced membrane-associated (P < 0.05) and increased cytosol (P < 0.01) PKC activity, while phorbol-12-myristate, 13-acetate (PMA) 0.1 mumol litre-1, a metabolically stable activator of PKC, reduced membrane (P < 0.01) without altering cytosol PKC activity.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	219-222
9068340-3	1997	Halothane alone (2.4 vol%) reduced membrane-associated (P < 0.05) and increased cytosol (P < 0.01) PKC activity, while phorbol-12-myristate, 13-acetate (PMA) 0.1 mumol litre-1, a metabolically stable activator of PKC, reduced membrane (P < 0.01) without altering cytosol PKC activity.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	219-222
9068340-4	1997	Halothane and PMA in combination reduced membrane PKC activity to undetectable levels and reduced cytosol PKC activity (P < 0.01).	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	50-53
9068340-4	1997	Halothane and PMA in combination reduced membrane PKC activity to undetectable levels and reduced cytosol PKC activity (P < 0.01).	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	106-109
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Halothane	129-138	protein kinase C, alpha	Rattus norvegicus	50-59
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Halothane	129-138	protein kinase C, beta	Rattus norvegicus	61-69
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Halothane	129-138	protein kinase C, gamma	Rattus norvegicus	73-82
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Halothane	129-138	protein kinase C, alpha	Rattus norvegicus	50-53
9068340-8	1997	Halothane and PMA together reduced cytosol PKC alpha/beta/gamma immunoreactivity significantly more (P < 0.05) than PMA alone.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	43-52
9068340-9	1997	Halothane thus has two distinct actions on PKC in synaptosomes: activation of endogenous PKC activity and potentiation of activation-induced cPKC translocation and down-regulation.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	43-46
9068340-9	1997	Halothane thus has two distinct actions on PKC in synaptosomes: activation of endogenous PKC activity and potentiation of activation-induced cPKC translocation and down-regulation.	Halothane	0-9	protein kinase C, alpha	Rattus norvegicus	89-92
9068340-10	1997	These potentially competing effects may underlie some of the conflicting results obtained with halothane on PKC-mediated processes in intact cells.	Halothane	95-104	protein kinase C, alpha	Rattus norvegicus	108-111
9038949-1	1997	We have recently reported that halothane (Hal) anesthesia attenuates the pulmonary vasodilator responses to both bradykinin (BK) and sodium nitroprusside (SNP) compared with responses measured in the conscious state.	Halothane	31-40	kininogen 1	Homo sapiens	113-123
9038949-1	1997	We have recently reported that halothane (Hal) anesthesia attenuates the pulmonary vasodilator responses to both bradykinin (BK) and sodium nitroprusside (SNP) compared with responses measured in the conscious state.	Halothane	31-40	kininogen 1	Homo sapiens	125-127
9038949-1	1997	We have recently reported that halothane (Hal) anesthesia attenuates the pulmonary vasodilator responses to both bradykinin (BK) and sodium nitroprusside (SNP) compared with responses measured in the conscious state.	Halothane	42-45	kininogen 1	Homo sapiens	113-123
9038949-1	1997	We have recently reported that halothane (Hal) anesthesia attenuates the pulmonary vasodilator responses to both bradykinin (BK) and sodium nitroprusside (SNP) compared with responses measured in the conscious state.	Halothane	42-45	kininogen 1	Homo sapiens	125-127
9038949-10	1997	Thus Iso and Hal selectively attenuate the endothelium-dependent pulmonary vasodilator response to BK.	Halothane	13-16	kininogen 1	Homo sapiens	99-101
9048222-7	1997	Both prenatal halothane and TFAA exposure produced changes in liver biochemistry of newborns, as indicated by significant increases in the serum activities of glutamate dehydrogenase and aspartate aminotransferase.	Halothane	14-23	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	187-213
9074803-0	1997	UDP-glucose:glycoprotein glucosyltransferase associates with endoplasmic reticulum chaperones and its activity is decreased in vivo by the inhalation anesthetic halothane.	Halothane	161-170	UDP-glucose glycoprotein glucosyltransferase 1	Rattus norvegicus	0-44
9074803-7	1997	Moreover, treatment of rats with halothane caused a 44% decrease in the activity of liver microsomal UGGT, and at least 36% of the change in the activity of the enzyme could be due to a decrease in the level of the protein.	Halothane	33-42	UDP-glucose glycoprotein glucosyltransferase 1	Rattus norvegicus	101-105
9074803-8	1997	The results suggest that the function of UGGT in folding of N-linked glycoproteins may be affected by other resident ER proteins or xenobiotics such as halothane.	Halothane	152-161	UDP-glucose glycoprotein glucosyltransferase 1	Rattus norvegicus	41-45
9008642-11	1997	The propagation of the Ca2+ wave could be blocked by the gap-junction blocker halothane and partially by K(+)-rich solution.	Halothane	78-87	carbonic anhydrase 2	Rattus norvegicus	23-26
9014627-6	1996	Two patients exhibited an unexpectedly large increase in GSTA (peaks 370 and 620 micrograms litre-1) and a mild increase in alanine aminotransferase after halothane anaesthesia.	Halothane	155-164	glutamic--pyruvic transaminase	Homo sapiens	124-148
8995600-0	1997	HSP72 expression in malignant hyperthermia and normal muscle following exposure to caffeine and halothane.	Halothane	96-105	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
8971135-7	1996	Covalent binding ranged from 10 to 40 pmol equivalents of halothane bound/mg protein/min and was highly correlated (r2 = 0.93) with the sample-to-sample variation in chlorzoxazone 6-hydroxylase activity, which reflects the levels of CYP2E1.	Halothane	58-67	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	233-239
8971135-8	1996	These results suggest that CYP2E1 is the high-affinity enzyme in human liver microsomes responsible for activating halothane to a reactive metabolite.	Halothane	115-124	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	27-33
8971135-12	1996	In conclusion, at pharmacologically relevant concentrations, the covalent binding of halothane to human liver microsomes is primarily catalyzed by CYP2E1.	Halothane	85-94	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	147-153
8916833-6	1996	Although basal [Ca2+]i was unaltered by the anesthetics, both halothane and enflurane, in a dose-dependent manner, depressed the peak and plateau of the [Ca2+]i transient elicited by 10 nM bradykinin, whereas isoflurane had no effect.	Halothane	62-71	kininogen 1	Bos taurus	189-199
8968190-5	1996	The changes induced in the direct-current potential in the hippocampal CA1 area by forebrain ischemia were compared in animals anesthetized with halothane and those given thiopental.	Halothane	145-154	carbonic anhydrase 1	Homo sapiens	71-74
8873559-0	1996	Halothane and diazepam inhibit ketamine-induced c-fos expression in the rat cingulate cortex.	Halothane	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
8873559-4	1996	METHODS: The effects of diazepam and halothane on c-Fos expression induced by ketamine were studied.	Halothane	37-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-55
8873559-11	1996	Halothane suppressed the ketamine-induced c-Fos-like immunoreactivity in the cingulate and retrosplenial cortices and the neocortex in a dose-dependent manner, leaving the thalamus relatively unaffected.	Halothane	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-47
8873559-12	1996	CONCLUSION: Halothane and diazepam inhibited ketamine-induced c-Fos expression in the cingulate and retrosplenial cortices, leaving the thalamus relatively unaffected.	Halothane	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
8902272-5	1996	In addition, because cytochrome P450 2E1 became trifluoroacetylated when it oxidatively metabolized halothane, it is possible that the covalently altered form of cytochrome P450 2E1 may be able to bypass the immunologic tolerance that normally exists against cytochrome P450 2E1.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	21-40
8916833-9	1996	CONCLUSIONS: Halothane and enflurane, but not isoflurane, inhibit bradykinin- and adenosine triphosphate-stimulated Ca2+ transients in endothelial cells.	Halothane	13-22	kininogen 1	Bos taurus	66-76
8886607-0	1996	Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.	Halothane	16-25	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	62-81
8902272-5	1996	In addition, because cytochrome P450 2E1 became trifluoroacetylated when it oxidatively metabolized halothane, it is possible that the covalently altered form of cytochrome P450 2E1 may be able to bypass the immunologic tolerance that normally exists against cytochrome P450 2E1.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	162-181
8902272-5	1996	In addition, because cytochrome P450 2E1 became trifluoroacetylated when it oxidatively metabolized halothane, it is possible that the covalently altered form of cytochrome P450 2E1 may be able to bypass the immunologic tolerance that normally exists against cytochrome P450 2E1.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	162-181
8780286-0	1996	The effects of halothane on arginine-vasopressin-induced Ca2+ mobilization from the intracellular stores and the receptor-mediated Ca2+ entry from the extracellular space in single cultured smooth muscle cells of rat aorta.	Halothane	15-24	arginine vasopressin	Rattus norvegicus	37-48
8780286-2	1996	Using digital imaging microscopy with the Ca2+ indicator fura-2, the effects of halothane on the intracellular [Ca2+] dynamics induced by arginine vasopressin (AVP) in the perinuclear region and cytosol in single cultured smooth muscle cells of rat aorta were studied.	Halothane	80-89	arginine vasopressin	Rattus norvegicus	147-158
8780286-2	1996	Using digital imaging microscopy with the Ca2+ indicator fura-2, the effects of halothane on the intracellular [Ca2+] dynamics induced by arginine vasopressin (AVP) in the perinuclear region and cytosol in single cultured smooth muscle cells of rat aorta were studied.	Halothane	80-89	arginine vasopressin	Rattus norvegicus	160-163
8780286-5	1996	Halothane, 0.5%, attenuated the [Ca2+] increase induced by AVP in the perinuclear region and cytosol, and halothane, 1.0% and 2.0%, abolished the differential increase.	Halothane	0-9	arginine vasopressin	Rattus norvegicus	59-62
8896011-6	1996	IL-6 was measured in 10 mice undergoing halothane anesthesia or combined halothane-spinal anesthesia.	Halothane	40-49	interleukin 6	Mus musculus	0-4
8794896-2	1996	In the present investigation, trifluoroacetylated CYP2E1 was detected immunochemically in livers of rats treated with halothane.	Halothane	118-127	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	50-56
8870048-2	1996	In support of previous findings by others, it was found that blockade of beta-1 and beta-2 receptors by propranolol delayed arousal from halothane anesthesia and that this effect was attributable to blockade of beta-1 receptors because it was duplicated by betaxolol but not by ICI 118,551.	Halothane	137-146	hemoglobin, beta adult major chain	Mus musculus	73-79
8870048-2	1996	In support of previous findings by others, it was found that blockade of beta-1 and beta-2 receptors by propranolol delayed arousal from halothane anesthesia and that this effect was attributable to blockade of beta-1 receptors because it was duplicated by betaxolol but not by ICI 118,551.	Halothane	137-146	hemoglobin, beta adult minor chain	Mus musculus	84-90
8896011-6	1996	IL-6 was measured in 10 mice undergoing halothane anesthesia or combined halothane-spinal anesthesia.	Halothane	73-82	interleukin 6	Mus musculus	0-4
8712453-10	1996	RESULTS: The results of the current study indicate that the initial Ca2+ increase in response to bradykinin stimulation is not affected by halothane, but that pulse applications of halothane (0.4-2 mM) or isoflurane (0.5-1 mM) reversibly reduce the sustained cytosolic Ca2+ increase initiated either by bradykinin or by the Ca2+ pump inhibitor thapsigargin.	Halothane	181-190	kininogen 1	Bos taurus	97-107
8712453-0	1996	Effects of halothane and isoflurane on bradykinin-evoked Ca2+ influx inbovine aortic endothelial cells.	Halothane	11-20	kininogen 1	Bos taurus	39-49
8712453-4	1996	METHODS: The effect of halothane and isoflurane on the Ca2+ response to bradykinin of bovine aortic endothelial (BAE) cells was investigated using the fluorescent Ca2+ indicator fura-2.	Halothane	23-32	kininogen 1	Bos taurus	72-82
8741472-3	1996	We studied the depressant effects of halothane, isoflurane, enflurane, and sevoflurane on MSR amplitudes as a function of anesthetic concentration comparing with MAC value of each anesthetics.	Halothane	37-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	90-93
8741472-8	1996	Concentration-response curves for MSR amplitudes were constructed and the concentrations which produced a half-maximum inhibition (IC50) were 0.56, 0.65, 0.97 and 1.18 mM for halothane, isoflurane, enflurane, and sevoflurane, respectively.	Halothane	175-184	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	34-37
8637342-4	1996	This investigation tested the hypothesis that cytochrome P450 2E1 (CYP2E1) is responsible for human halothane metabolism in vivo.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-65
8637342-4	1996	This investigation tested the hypothesis that cytochrome P450 2E1 (CYP2E1) is responsible for human halothane metabolism in vivo.	Halothane	100-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	67-73
8771374-10	1996	These results suggest that halothane suppresses rat T cell function, perhaps through suppression of IL-2 receptor expression.	Halothane	27-36	interleukin 2	Rattus norvegicus	100-104
8866452-11	1996	Lactate and AVP increased during halothane anaesthesia.	Halothane	33-42	arginine vasopressin	Homo sapiens	12-15
8694388-2	1996	The current study aimed to clarify the inhibitory mechanisms of halothane on thrombin-induced human platelet aggregation by measuring (1) platelet-surface glycoprotein Ib expression, (2) the concentration of intracellular free Ca2+ ([Ca2+]i) measured simultaneously with aggregation, (3) the concentration of intracellular inositol 1,4,5-triphosphate, and (4) the concentration of intracellular cyclic 3",5"-adenosine monophosphate ([cAMP]i).	Halothane	64-73	coagulation factor II, thrombin	Homo sapiens	77-85
8694388-8	1996	Halothane decreased the thrombin stimulated [Ca2+]i transient and inhibited platelet aggregation in a dose-dependent manner, both in the presence and in the absence of external Ca2+.	Halothane	0-9	coagulation factor II, thrombin	Homo sapiens	24-32
8694388-10	1996	Halothane inhibited the increase in inositol 1,4,5-triphosphate induced by thrombin.	Halothane	0-9	coagulation factor II, thrombin	Homo sapiens	75-83
8694388-12	1996	CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i.	Halothane	13-22	coagulation factor II, thrombin	Homo sapiens	32-40
8694388-12	1996	CONCLUSIONS: Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i.	Halothane	168-177	coagulation factor II, thrombin	Homo sapiens	32-40
9026185-1	1996	Halothane monoanesthesia in hypoxia leads to activation of lipolysis with increase in the content of NEFA and POL products.	Halothane	0-9	endogenous retrovirus group W member 4	Homo sapiens	110-113
8809847-1	1996	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk B mRNA, in brain.	Halothane	42-51	brain-derived neurotrophic factor	Rattus norvegicus	78-111
8809847-1	1996	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk B mRNA, in brain.	Halothane	42-51	brain-derived neurotrophic factor	Rattus norvegicus	113-117
8809847-1	1996	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk B mRNA, in brain.	Halothane	42-51	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	137-142
8712453-10	1996	RESULTS: The results of the current study indicate that the initial Ca2+ increase in response to bradykinin stimulation is not affected by halothane, but that pulse applications of halothane (0.4-2 mM) or isoflurane (0.5-1 mM) reversibly reduce the sustained cytosolic Ca2+ increase initiated either by bradykinin or by the Ca2+ pump inhibitor thapsigargin.	Halothane	181-190	kininogen 1	Bos taurus	303-313
8712453-11	1996	In addition, halothane appeared to dose-dependently inhibit the Ca2+ influx evoked by bradykinin, and to cause, concomitant to a decrease in cytosolic Ca2+ concentration, a depolarization of the cell potential.	Halothane	13-22	kininogen 1	Bos taurus	86-96
8712453-14	1996	CONCLUSIONS: These observations suggest that the effects of halothane and isoflurane on Ca2+ homeostasis in BAE cells reflect, for the most part, a reduction of the thapsigargin- or bradykinin-evoked Ca2+ influx, which would be consequent to a cellular depolarization caused by an inhibition of the Ca(2+)-dependent K+ channel activity initiated after cell stimulation.	Halothane	60-69	kininogen 1	Bos taurus	182-192
8734993-2	1996	A prominent in vivo effect of general anaesthetics, including volatile anaesthetics such as halothane, is the prolonging of paired-pulse depression of the hippocampal CA1 population spike.	Halothane	92-101	carbonic anhydrase 1	Rattus norvegicus	167-170
8610122-1	1996	To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes.	Halothane	91-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	138-170
8610122-1	1996	To determine inhalational anesthetic binding domains on a ligand-gated ion channel, I used halothane direct photoaffinity labeling of the nicotinic acetylcholine receptor (nAChR) in native Torpedo membranes.	Halothane	91-100	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	172-177
8610122-2	1996	[14C]Halothane photoaffinity labeling of both the native Torpedo membranes and the isolated nAChR was saturable, with Kd values within the clinically relevant range.	Halothane	5-14	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	92-97
8610122-6	1996	Unlabeled halothane reduced labeling more than did isoflurane, suggesting differences in the binding domains for inhalational anesthetics in the nAChR.	Halothane	10-19	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	145-150
8610122-7	1996	These data suggest multiple similar binding domains for halothane in the transmembrane region of the nAChR.	Halothane	56-65	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	101-106
8638845-4	1996	RESULTS: Ketamine and halothane reduced Kv2.1 and delta C318 peak current amplitude in a dose-dependent and reversible fashion.	Halothane	22-31	potassium voltage-gated channel subfamily B member 1	Homo sapiens	40-45
8638845-7	1996	Use dependence of ketamine and halothane action was observed in both Kv2.1 and the mutant channel, attributable to augmentation of C-type inactivation.	Halothane	31-40	potassium voltage-gated channel subfamily B member 1	Homo sapiens	69-74
8638845-8	1996	CONCLUSIONS: Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different.	Halothane	40-49	potassium voltage-gated channel subfamily B member 1	Homo sapiens	89-94
8638850-10	1996	Microinjection of carbachol into the mPRF before halothane administration caused a significant reduction in number of halothane-induced EEG spindles.	Halothane	118-127	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	37-41
8638850-11	1996	CONCLUSIONS: Laterodorsal and pedunculopontine tegmental neurons, which provide cholinergic input to the mPRF, play a causal role in generating the EEG spindles of halothane anesthesia.	Halothane	164-173	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	105-109
8708176-11	1996	Anti-TNF antibody reduced the contracture response to halothane in the presence of TNF (p < 0.05).	Halothane	54-63	tumor necrosis factor	Homo sapiens	5-8
8708176-11	1996	Anti-TNF antibody reduced the contracture response to halothane in the presence of TNF (p < 0.05).	Halothane	54-63	tumor necrosis factor	Homo sapiens	83-86
8907361-1	1996	Immunohistochemical detection of the protein product (Fos) of the c-fos immediate early gene was used to study neuronal activation in the rostral pons and midbrain of halothane-anesthetised rats following noxious deep somatic or noxious visceral stimulation.	Halothane	167-176	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-57
8907361-1	1996	Immunohistochemical detection of the protein product (Fos) of the c-fos immediate early gene was used to study neuronal activation in the rostral pons and midbrain of halothane-anesthetised rats following noxious deep somatic or noxious visceral stimulation.	Halothane	167-176	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-71
8907361-2	1996	In animals exposed only to halothane anesthesia, Fos-like immunoreactive (IR) neurons were located in the midbrain periaqueductal gray matter, tectum, and parabrachial nucleus.	Halothane	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-52
8907361-3	1996	Following noxious stimulation of hindlimb muscle, knee joint, vagal cardiopulmonary, or peritoneal nociceptors, there was, compared to halothane-only animals, a significant increase in the numbers of Fos-like (IR) cells in the caudal ventrolateral periaqueductal gray and the intermediate gray lamina of the superior colliculus.	Halothane	135-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	200-203
8659794-5	1996	RESULTS: Halothane stimulated basal Ca2+ dependent phosphorylation of MARCKS (Mr = 83,000) in lysed synaptic membranes (2.1-fold; P< 0.01) and in intact synaptosomes (1.4-fold; P< 0.01).	Halothane	9-18	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	70-76
8659794-9	1996	However, halothane stimulated synapsin 1 phosphorylation evoked by ionomycin (a Ca2+ ionophore that permeabilizes membranes to Ca2+) in intact synaptosomes.	Halothane	9-18	synapsin I	Rattus norvegicus	30-40
8786535-7	1996	Isoflurane weakly inhibited although enflurane and halothane modestly inhibited kainate responses in oocytes expressing GluR1, GluR3 or GluR2+3 receptors.	Halothane	51-60	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	120-125
8786535-7	1996	Isoflurane weakly inhibited although enflurane and halothane modestly inhibited kainate responses in oocytes expressing GluR1, GluR3 or GluR2+3 receptors.	Halothane	51-60	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	127-132
8786535-8	1996	As with F3, isoflurane, enflurane and halothane potentiated kainate-induced currents of GluR6 receptors.	Halothane	38-47	glutamate receptor, ionotropic, kainate 2 S homeolog	Xenopus laevis	88-93
8786535-9	1996	The respective inhibitory and potentiating effects of halothane on GluR3 and GluR6 receptors were enhanced by increasing duration of halothane exposure.	Halothane	54-63	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	67-72
8786535-9	1996	The respective inhibitory and potentiating effects of halothane on GluR3 and GluR6 receptors were enhanced by increasing duration of halothane exposure.	Halothane	54-63	glutamate receptor, ionotropic, kainate 2 S homeolog	Xenopus laevis	77-82
8786535-9	1996	The respective inhibitory and potentiating effects of halothane on GluR3 and GluR6 receptors were enhanced by increasing duration of halothane exposure.	Halothane	133-142	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	67-72
8786535-9	1996	The respective inhibitory and potentiating effects of halothane on GluR3 and GluR6 receptors were enhanced by increasing duration of halothane exposure.	Halothane	133-142	glutamate receptor, ionotropic, kainate 2 S homeolog	Xenopus laevis	77-82
7478932-5	1995	Single rat and human Cx43 gap junction channels were resolved in the presence of halothane.	Halothane	81-90	gap junction protein alpha 1	Homo sapiens	21-25
8746545-6	1995	These data indicate, for the first time, that microinjection of PP into the DVC may potentiate glucose-stimulated insulin secretion in halothane-anesthetized rats.	Halothane	135-144	pancreatic polypeptide	Rattus norvegicus	64-66
8672327-0	1995	Effects of halothane, enflurane and isoflurane on contraction of rat aorta induced by endothelin-1.	Halothane	11-20	endothelin 1	Rattus norvegicus	86-98
8672327-2	1995	These studies were performed to see if halothane, enflurane and isoflurane attenuate endothelin-1-evoked contraction and if they interact with endothelium-dependent or -independent vasoactive substances.	Halothane	39-48	endothelin 1	Rattus norvegicus	85-97
7491971-7	1995	Halothane inhibited inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] production in response to both 1 and 10 nM CCK (31 and 40% inhibition, respectively), possibly explaining its effects on [Ca2+]i oscillations, whereas octanol showed no significant inhibition.	Halothane	0-9	cholecystokinin	Homo sapiens	107-110
7631954-0	1995	Binding of halothane to serum albumin demonstrated using tryptophan fluorescence.	Halothane	11-20	albumin	Homo sapiens	24-37
7631954-2	1995	Saturable binding of halothane to bovine serum albumin (BSA) has recently been reported using photoaffinity labeling and fluorine 19 nuclear magnetic resonance spectroscopy.	Halothane	21-30	albumin	Homo sapiens	41-54
7478181-1	1995	We measured the increase of regional cerebral blood flow (rCBF) in the somatosensory cerebral cortex occurring in response to a standard stimulation of the L. side mystacial vibrissae (facial whiskers) in rats anaesthetised with halothane, in conjunction with blocking of activity in the R. side parasympathetic (PS) and sensory fibres innervating the cerebral vessels.	Halothane	229-238	CCAAT/enhancer binding protein zeta	Rattus norvegicus	58-62
7604990-4	1995	METHODS: The fluorescence emission of calmodulin was obtained over a range of Ca2+ concentrations (10(-7)-10(-4)M) in the presence and absence of halothane and isoflurane.	Halothane	146-155	calmodulin	Bos taurus	38-48
7604990-12	1995	At 0.57% (0.25 mM) halothane and 1.7% (0.66 mM) isoflurane, the affinity of calmodulin for Ca2+ relative to control was decreased.	Halothane	19-28	calmodulin	Bos taurus	76-86
7604990-0	1995	Halothane and isoflurane alter the Ca2+ binding properties of calmodulin.	Halothane	0-9	calmodulin	Bos taurus	62-72
7793655-3	1995	We have previously demonstrated beta 2-adrenergic receptor-augmented release of NE in the human forearm and have shown that halothane inhibits sympathetic activity in vivo by decreasing the NE spillover rate into plasma.	Halothane	124-133	adrenoceptor beta 2	Homo sapiens	32-58
7604990-3	1995	We therefore examined the effects of halothane and isoflurane on the Ca(2+)-binding properties of bovine brain calmodulin.	Halothane	37-46	calmodulin	Bos taurus	111-121
7552780-7	1995	Unanesthetized injured mice exhibited maximal lung myeloperoxidase activity 2 h after zymosan injection (.671 +/- .07 delta OD.min-1), which was significantly attenuated (p < .01) in injured mice anesthetized with halothane (.369 +/- .054) and isoflurane (.324 +/- .055).	Halothane	217-226	myeloperoxidase	Mus musculus	51-66
7793655-10	1995	CONCLUSIONS: The isoproterenol-mediated increase in NE release is inhibited by halothane anesthesia, indicating that halothane inhibits prejunctional beta 2-adrenergic receptor regulation of NE release.	Halothane	117-126	adrenoceptor beta 2	Homo sapiens	150-176
7793655-4	1995	The goal of the current study was to determine the effect of halothane on beta 2-adrenergic receptor-augmented NE release in a canine hind-limb experimental model.	Halothane	61-70	adrenoceptor beta 2	Homo sapiens	74-100
7793655-10	1995	CONCLUSIONS: The isoproterenol-mediated increase in NE release is inhibited by halothane anesthesia, indicating that halothane inhibits prejunctional beta 2-adrenergic receptor regulation of NE release.	Halothane	79-88	adrenoceptor beta 2	Homo sapiens	150-176
7674850-6	1995	Halothane is known to attenuate the changes in regional glucose utilisation produced by the noncompetitive NMDA antagonist dizocilpine (MK-801), and its effects on ketamine-induced changes in rCBF seen in this study may be due to a similar effect.	Halothane	0-9	CCAAT/enhancer binding protein zeta	Rattus norvegicus	192-196
7793657-3	1995	Another alpha 1 subtype (alpha 1A), sensitive to the competitive antagonist WB4101, increases spontaneous rate and action potential duration by a mechanism thought to involve hydrolysis of membrane phosphoinositides by phospholipase C. This study examined the dose-response relation and receptor-effector mechanisms underlying depression of conduction in canine Purkinje fibers by epinephrine with halothane.	Halothane	398-407	adrenoceptor alpha 1A	Canis lupus familiaris	25-33
7793657-10	1995	Other agonists linked to cardiac phospholipase C activation, including endothelin 1 (40 nM) and the muscarinic agonist carbamylcholine (1 mM), also decreased conduction velocity in fibers exposed to halothane.	Halothane	199-208	endothelin 1	Canis lupus familiaris	71-83
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Halothane	210-219	glutamic--pyruvic transaminase	Homo sapiens	105-134
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Halothane	210-219	glutamic--pyruvic transaminase	Homo sapiens	136-139
7537186-0	1995	Biological variation and the effect of fasting and halothane anesthesia on plasma glutathione S-transferase concentrations.	Halothane	51-60	glutathione S-transferase kappa 1	Homo sapiens	82-107
7546035-4	1995	The anesthetic halothane can inhibit the released neutral and acid DNase activities.	Halothane	15-24	deoxyribonuclease 2, lysosomal	Homo sapiens	62-72
7856894-3	1995	This study was undertaken to examine the effects of halothane and isoflurance on the distribution of CBF.	Halothane	52-61	CCAAT/enhancer binding protein zeta	Rattus norvegicus	101-104
7856894-16	1995	CONCLUSIONS: There is a difference in the human rCBF distribution between halothane and isoflurane with higher relative flows in subcortical regions during isoflurane anesthesia.	Halothane	74-83	CCAAT/enhancer binding protein zeta	Rattus norvegicus	48-52
7870045-4	1995	Thus, transfection with the beta 2 subunit reduced the efficacy of both isoflurane and halothane, whereas transfection with the beta 3 subunit increased the efficacy of isoflurane but not halothane, compared with values obtained in WSS-1 cells.	Halothane	87-96	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
7789177-6	1995	The localization of LHB to the so-called halothane region of chromosome 6 could be expected from comparative mapping data.	Halothane	41-50	lutropin subunit beta	Sus scrofa	20-23
7830493-8	1995	However, during NO-stimulation halothane produced significant, concentration-dependent, inhibition of sGC activity over a wide range of NO concentrations.	Halothane	31-40	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	102-105
7716787-5	1995	CF3CO-proteins are elicited in the course of oxidative biotransformation of halothane, and include the trifluoroacetylated forms of protein disulfide isomerase, microsomal carboxylesterase, calreticulin, ERp72, GRP 78, and ERp99.	Halothane	76-85	protein disulfide isomerase family A member 4	Homo sapiens	204-209
7716787-5	1995	CF3CO-proteins are elicited in the course of oxidative biotransformation of halothane, and include the trifluoroacetylated forms of protein disulfide isomerase, microsomal carboxylesterase, calreticulin, ERp72, GRP 78, and ERp99.	Halothane	76-85	heat shock protein family A (Hsp70) member 5	Homo sapiens	211-217
7832302-8	1995	RESULTS: Halothane anesthesia significantly reduced the slope of the response of expiratory minute ventilation to carbon dioxide (from 2.88 +/- 0.73 (mean +/- SE) to 2.01 +/- 0.45 l.min-1.mmHg-1).	Halothane	9-18	CD59 molecule (CD59 blood group)	Homo sapiens	182-187
7823136-9	1995	Halothane anesthesia prevented the occurrence of high-frequency field oscillations in the CA1 region.	Halothane	0-9	carbonic anhydrase 1	Rattus norvegicus	90-93
7837396-7	1994	MAP 2 in the frontoparietal cortex and hippocampus was significantly protected from degradation with isoflurane anaesthesia more than with halothane and sevoflurane anaesthesia.	Halothane	139-148	microtubule-associated protein 2	Rattus norvegicus	0-5
7978411-5	1994	Halothane median effective concentration (EC50) was determined by using the end-point of loss of righting reflex in two replicate lines of mice selected for diazepam sensitivity (resistant mice = diazepam high performance-1 and -2 [DHP-1 and DHP-2], sensitive mice = diazepam low performance-1 and -2 [DLP-1 and DLP-2]).	Halothane	0-9	deoxyribonuclease 1-like 3	Mus musculus	242-247
7978411-5	1994	Halothane median effective concentration (EC50) was determined by using the end-point of loss of righting reflex in two replicate lines of mice selected for diazepam sensitivity (resistant mice = diazepam high performance-1 and -2 [DHP-1 and DHP-2], sensitive mice = diazepam low performance-1 and -2 [DLP-1 and DLP-2]).	Halothane	0-9	dynamin 1-like	Mus musculus	302-307
7978411-6	1994	DLP-1 and DLP-2 mice were sensitive to halothane, whereas DHP-1 and DHP-2 mice were resistant to halothane.	Halothane	39-48	dynamin 1-like	Mus musculus	0-5
7978411-6	1994	DLP-1 and DLP-2 mice were sensitive to halothane, whereas DHP-1 and DHP-2 mice were resistant to halothane.	Halothane	97-106	deoxyribonuclease 1-like 3	Mus musculus	68-73
7978411-7	1994	Halothane EC50 in the DLP-1 and DHP-1 mice was 0.86 +/- 0.01 (SE) and 1.10 +/- 0.04 atm%, respectively (P < 0.0001), and that in the DLP-2 and DHP-2 mice was 0.88 +/- 0.01 and 0.97 +/- 0.02 atm%, respectively (P < 0.0001).	Halothane	0-9	dynamin 1-like	Mus musculus	22-27
7978411-7	1994	Halothane EC50 in the DLP-1 and DHP-1 mice was 0.86 +/- 0.01 (SE) and 1.10 +/- 0.04 atm%, respectively (P < 0.0001), and that in the DLP-2 and DHP-2 mice was 0.88 +/- 0.01 and 0.97 +/- 0.02 atm%, respectively (P < 0.0001).	Halothane	0-9	deoxyribonuclease 1-like 3	Mus musculus	146-151
7943843-0	1994	Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells.	Halothane	0-9	kininogen 1	Bos taurus	19-29
7943843-8	1994	Halothane inhibited the response to bradykinin but not the response to ATP or melittin.	Halothane	0-9	kininogen 1	Bos taurus	36-46
7943843-12	1994	Halothane inhibited the bradykinin-stimulated prostacyclin production but not that stimulated by ATP or melittin.	Halothane	0-9	kininogen 1	Bos taurus	24-34
7943843-13	1994	These results suggest that the halothane-mediated inhibition of bradykinin-stimulated prostacyclin production does not involve a pertussis toxin-sensitive G-protein and may result from an interaction of halothane at some other step in the signal transduction pathway, including the inhibition of protein kinase C.	Halothane	31-40	kininogen 1	Bos taurus	64-74
7943843-13	1994	These results suggest that the halothane-mediated inhibition of bradykinin-stimulated prostacyclin production does not involve a pertussis toxin-sensitive G-protein and may result from an interaction of halothane at some other step in the signal transduction pathway, including the inhibition of protein kinase C.	Halothane	203-212	kininogen 1	Bos taurus	64-74
7522498-0	1994	Influence of halothane on the effect of cAMP-dependent and cAMP-independent positive inotropic agents in human myocardium.	Halothane	13-22	cathelicidin antimicrobial peptide	Homo sapiens	40-63
7526150-0	1994	Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats.	Halothane	113-122	selenoprotein K	Rattus norvegicus	29-47
7526150-1	1994	Previous studies have shown that exposure of phenobarbital-pretreated rats to halothane in 10% O2 causes centrilobular necrosis, induces expression of the 72-kDa heat shock protein (HSP72), and produces several trifluoroacetylated adducts.	Halothane	78-87	selenoprotein K	Rattus norvegicus	162-180
7526150-1	1994	Previous studies have shown that exposure of phenobarbital-pretreated rats to halothane in 10% O2 causes centrilobular necrosis, induces expression of the 72-kDa heat shock protein (HSP72), and produces several trifluoroacetylated adducts.	Halothane	78-87	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	182-187
7526150-9	1994	In contrast, HSP72 was induced only in the rats pretreated with phenobarbital and exposed to 1% halothane in 10% O2.	Halothane	96-105	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	13-18
7845474-3	1994	A possible link between MH induced by 5-HT2A receptor agonists and halothane could be an increase of second messengers such as phosphoinositides (inositol polyphosphates), which have recently been implicated in the abnormal regulation of skeletal muscle calcium release in MH.	Halothane	67-76	5-hydroxytryptamine receptor 2A	Sus scrofa	38-53
7845474-4	1994	If so, antagonists of 5-HT2A receptors which are linked to phosphoinositide turnover should be capable of preventing, retarding or attenuating halothane-induced MH.	Halothane	143-152	5-hydroxytryptamine receptor 2A	Sus scrofa	22-28
8092510-4	1994	Our second objective was to investigate the effects of halothane and pentobarbital anesthesia on the pulmonary vascular response to AVP after inducing the same degree of pulmonary preconstriction achieved in the conscious state.	Halothane	55-64	arginine vasopressin	Canis lupus familiaris	132-135
8092510-11	1994	In contrast, despite identical levels of U46619 preconstriction, the pulmonary vasodilator response to AVP was either reversed to vasoconstriction (P < 0.05) or abolished during halothane and pentobarbital anesthesia.	Halothane	181-190	arginine vasopressin	Canis lupus familiaris	103-106
8063876-1	1994	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced c-fos, junB, and c-jun immediate early gene mRNAs and hsp70 heat shock gene mRNA in brain.	Halothane	42-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-83
8063876-1	1994	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced c-fos, junB, and c-jun immediate early gene mRNAs and hsp70 heat shock gene mRNA in brain.	Halothane	42-51	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-89
8063876-1	1994	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced c-fos, junB, and c-jun immediate early gene mRNAs and hsp70 heat shock gene mRNA in brain.	Halothane	42-51	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	132-137
7824182-0	1994	PEC-60 increases dopamine but not GABA release in the dorsolateral neostriatum of the halothane anaesthetized rat.	Halothane	86-95	serine peptidase inhibitor, Kazal type 4	Rattus norvegicus	0-6
8042784-0	1994	Effects of halothane and propofol on purified brain protein kinase C activation.	Halothane	11-20	protein kinase C, gamma	Rattus norvegicus	52-68
8042784-3	1994	This study examines the effects of halothane and propofol on the activity of purified rat brain PKC under various assay conditions.	Halothane	35-44	protein kinase C, gamma	Rattus norvegicus	96-99
8042784-5	1994	RESULTS: Both halothane (50% effective concentration = 2.2 vol%) and propofol (50% effective concentration = 240 microM) markedly stimulated histone H1 phosphorylation by PKC in the presence of a lipid vesicle preparation consisting of phosphatidylcholine, phosphatidylserine, and diacylglycerol.	Halothane	14-23	protein kinase C, gamma	Rattus norvegicus	171-174
8042784-8	1994	Slight inhibition of PKC activity by halothane was observed under specific assay conditions with protamine as substrate.	Halothane	37-46	protein kinase C, gamma	Rattus norvegicus	21-24
8042784-10	1994	CONCLUSIONS: Both halothane and propofol stimulated purified brain PKC activity in vitro assayed with physiologically relevant lipid bilayers in the absence or presence of Ca2+.	Halothane	18-27	protein kinase C, gamma	Rattus norvegicus	67-70
8042784-12	1994	The potencies of halothane and propofol in stimulating PKC in vitro are consistent with submaximal activation of PKC at clinically effective anesthetic concentrations, the pharmacologic significance of this effect requires confirmation in an intact cellular system.	Halothane	17-26	protein kinase C, gamma	Rattus norvegicus	55-58
8042784-12	1994	The potencies of halothane and propofol in stimulating PKC in vitro are consistent with submaximal activation of PKC at clinically effective anesthetic concentrations, the pharmacologic significance of this effect requires confirmation in an intact cellular system.	Halothane	17-26	protein kinase C, gamma	Rattus norvegicus	113-116
7958552-11	1994	The identity of BiP/Grp78 as the halothane hepatitis-associated trifluoroacetylated protein was also demonstrated.	Halothane	33-42	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	16-19
7958552-11	1994	The identity of BiP/Grp78 as the halothane hepatitis-associated trifluoroacetylated protein was also demonstrated.	Halothane	33-42	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	20-25
8027781-5	1994	Under conditions that reduce gap junctional conductance (intracellular acidification, octanol, halothane), seizure-like activity was suppressed in the CA1 area in this epilepsy model, whereas increasing gap junctional conductance by intracellular alkalinization increased the frequency and duration of field burst events.	Halothane	95-104	carbonic anhydrase 1	Homo sapiens	151-154
7520930-1	1994	Halothane anaesthesia in young sheep results in greatly increased plasma binding capacity for radiolabelled insulin-like growth factor (IGF), as demonstrated using size-exclusion chromatography.	Halothane	0-9	insulin	Homo sapiens	108-115
8010482-6	1994	The effects of halothane, isoflurane, and octanol on TRH-induced Ca2+ mobilization were assessed as a function of time and anesthetic concentration.	Halothane	15-24	thyrotropin releasing hormone	Rattus norvegicus	53-56
8010482-8	1994	RESULTS: Halothane increased resting [Ca2+]i and caused a time- and concentration-dependent inhibition of TRH-induced increases in [Ca2+]i (IC50 = 0.6 mM).	Halothane	9-18	thyrotropin releasing hormone	Rattus norvegicus	106-109
8198912-1	1994	We have examined the activity of choline acetyltransferase (ChAT) in rat cortical synaptosomes in the presence of three volatile anaesthetic agents: enflurane, halothane and isoflurane.	Halothane	160-169	choline O-acetyltransferase	Rattus norvegicus	33-58
8069986-12	1994	The peak CPK values in the three children who developed MMR were 17,580 IU.L-1 after halothane and Sch, and 7,280 IU.-1 and 3,273 IU.-1 after halothane, STP and Sch.	Halothane	85-94	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	9-12
7936192-1	1994	The main aim of the present study was to investigate the effects of local perfusion with the tridecapeptide neurotensin on extracellular GABA and dopamine levels in the nucleus accumbens of the halothane-anaesthetized rat, using in vivo microdialysis.	Halothane	194-203	neurotensin	Rattus norvegicus	108-119
8084481-1	1994	Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain.	Halothane	42-51	early growth response 1	Rattus norvegicus	100-106
8067234-4	1994	At 3 MAC of halothane, there were measurable decreases in brain phosphocreatine (69% of the control) and increases in brain inorganic phosphate (about 250% of control Pi), even though CBF was about 70% of the control value.	Halothane	12-21	CCAAT enhancer binding protein zeta	Homo sapiens	184-187
8135806-1	1994	Immunocytochemical studies have revealed that one of the major heat shock proteins, HSP72, is induced in livers of rats that have been pretreated with phenobarbital and then administered halothane in a hypoxic gas mixture of 10% oxygen.	Halothane	187-196	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	84-89
8135806-3	1994	Western blotting with a mouse monoclonal anti-HSP70 IgG antibody, which recognizes both the constitutive (HSP73) and inducible (HSP72) forms, revealed that HSP72 was induced and translocated into the nucleus in only those rats exposed to halothane under hypoxia following phenobarbital pretreatment.	Halothane	238-247	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	46-51
8135806-3	1994	Western blotting with a mouse monoclonal anti-HSP70 IgG antibody, which recognizes both the constitutive (HSP73) and inducible (HSP72) forms, revealed that HSP72 was induced and translocated into the nucleus in only those rats exposed to halothane under hypoxia following phenobarbital pretreatment.	Halothane	238-247	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	128-133
8135806-3	1994	Western blotting with a mouse monoclonal anti-HSP70 IgG antibody, which recognizes both the constitutive (HSP73) and inducible (HSP72) forms, revealed that HSP72 was induced and translocated into the nucleus in only those rats exposed to halothane under hypoxia following phenobarbital pretreatment.	Halothane	238-247	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	156-161
8017648-2	1994	Do isoflurane and halothane (0.5-3.0% in the gas phase) inhibit contractions evoked in isolated porcine coronary artery rings (without endothelium) by the specific Ca2+ mobilizing agonists serotonin, endothelin-1, and F-?	Halothane	18-27	endothelin 1	Homo sapiens	200-212
8141457-2	1994	METHODS: We determined the effect of halothane, enflurane, and isoflurane on the binding of the Ca2+ channel blocker PN200-110 to skeletal muscle membranes isolated from malignant hyperthermia-susceptible and normal pigs.	Halothane	37-46	carbonic anhydrase 2	Sus scrofa	96-99
28921207-2	1994	Inhalation of halothane under a hypoxic condition significantly increased serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in rats pretreated with phenobarbital compared with rats pretreated without phenobarbital.	Halothane	14-23	glutamic--pyruvic transaminase	Rattus norvegicus	124-153
28921207-2	1994	Inhalation of halothane under a hypoxic condition significantly increased serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in rats pretreated with phenobarbital compared with rats pretreated without phenobarbital.	Halothane	14-23	glutamic--pyruvic transaminase	Rattus norvegicus	155-158
8145725-5	1994	Halothane (1%) increased basal as well as isoprenaline-, NaF-, cholera toxin-, and guanylylimidodiphosphate [Gpp(NH)p]-stimulated adenylate cyclase in human myocardial membranes (p < 0.05).	Halothane	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
8145725-8	1994	The same results, i.e., a pertussis toxin-sensitive increase of adenylate cyclase stimulation by halothane, were obtained in S49 cyc-, wild-type, or recombinant Gs alpha-reconstituted cyc- cell membranes.	Halothane	97-106	GNAS complex locus	Homo sapiens	161-169
8306996-8	1994	The collective evidence of these data raises the possibility that exposure to halothane might lead to peroxidation-associated net synthesis of LTB4 through 5-lipoxygenase-independent escape routes in liver tissue under physiologically or pathophysiologically low O2 concentrations.	Halothane	78-87	arachidonate 5-lipoxygenase	Rattus norvegicus	156-170
8279258-4	1993	At 3 MAC of halothane, there were measurable decreases in brain phosphocreatine (69% of the control) and increases in brain inorganic phosphate (about 250% of control Pi), even though CBF was about 70% of the control value.	Halothane	12-21	CCAAT enhancer binding protein zeta	Homo sapiens	184-187
21395776-0	1994	Calcium-release-channel genotypes in several pig populations-associations with halothane and CK reactions.	Halothane	79-88	ryanodine receptor 1	Sus scrofa	0-23
7812809-3	1994	In halothane-exposed animals, Met-enkephalin concentrations in pit and across CNS areas studied were significantly lower at 2 h following anesthetic exposure than in control animals.	Halothane	3-12	proenkephalin	Rattus norvegicus	34-44
7812809-5	1994	Concentrations of Met-enkephalin in all areas studied except spinal cord returned to basal levels by 24 h following halothane exposure.	Halothane	116-125	proenkephalin	Rattus norvegicus	22-32
7903356-1	1994	In the present study, extracellular levels of the neuropeptide cholecystokinin (CCK), of the monoamine dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and of the excitatory amino acids glutamate and aspartate were simultaneously monitored by microdialysis in the neostriatum of halothane-anesthetized rats under basal and K(+)-depolarizing conditions.	Halothane	327-336	cholecystokinin	Rattus norvegicus	80-83
8251271-4	1993	In the presence of 0.1% inspired halothane, ventilation increased initially from 7.19 (0.47) litre min-1 to 12.08 (0.99) litre min-1 (P < 0.05), then decreased to 10.12 (0.28) litre min-1 during sustained hypoxia (ns compared with baseline normoxic ventilation).	Halothane	33-42	CD59 molecule (CD59 blood group)	Homo sapiens	99-104
8251271-4	1993	In the presence of 0.1% inspired halothane, ventilation increased initially from 7.19 (0.47) litre min-1 to 12.08 (0.99) litre min-1 (P < 0.05), then decreased to 10.12 (0.28) litre min-1 during sustained hypoxia (ns compared with baseline normoxic ventilation).	Halothane	33-42	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
8251271-4	1993	In the presence of 0.1% inspired halothane, ventilation increased initially from 7.19 (0.47) litre min-1 to 12.08 (0.99) litre min-1 (P < 0.05), then decreased to 10.12 (0.28) litre min-1 during sustained hypoxia (ns compared with baseline normoxic ventilation).	Halothane	33-42	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
8100812-10	1993	There were differences in color and drip loss between the halothane genotypes that cannot be explained by differences in pH and carcass temperature at 45 min postmortem.	Halothane	58-67	DRIPL	Sus scrofa	36-45
15278794-0	1993	Effect of halothane on intercellular adhesion molecule-1 (ICAM-1) in melanoma cells.	Halothane	10-19	intercellular adhesion molecule 1	Homo sapiens	23-56
15278794-0	1993	Effect of halothane on intercellular adhesion molecule-1 (ICAM-1) in melanoma cells.	Halothane	10-19	intercellular adhesion molecule 1	Homo sapiens	58-64
15278794-7	1993	ICAM-1 expression in cells exposed to halothane for 3, 6, 12 or 24 hours was lower than that of non-exposed cells and returned to control level after further incubation in 5% CO2 atmosphere for either 12 or 24 hours.	Halothane	38-47	intercellular adhesion molecule 1	Homo sapiens	0-6
7505359-4	1993	Halothane attenuated responses to the highest dose of NE and AII by approximately 18% but completely abolished responses to L-NNA and L-NAME.	Halothane	0-9	angiotensinogen	Rattus norvegicus	61-64
8289749-3	1993	Halothane did so most profoundly, resulting in a maximum slowing of 40 beats-1 compared with a maximum slowing of about 20 beats min-1 with both isoflurane and enflurane.	Halothane	0-9	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
8025247-1	1994	This study tested the hypothesis that halothane anesthesia would cause decreased acetylcholine (ACh) release within the medial pontine reticular formation (mPRF).	Halothane	38-47	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	156-160
8292737-0	1993	Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.	Halothane	22-31	protein disulfide isomerase family A, member 4	Rattus norvegicus	100-105
8292737-5	1993	These results indicate that trifluoroacetylated ERp72 in the liver of halothane hepatitis patients may induce immune responses against epitopes present on the covalently altered protein and those present on the native protein and may have a role in halothane hepatitis.	Halothane	70-79	protein disulfide isomerase family A member 4	Homo sapiens	48-53
8123401-7	1993	MtP2 degradation in the frontoparietal cortex and hippocampus was significantly (P < 0.05 and P < 0.01) less with isoflurane anaesthesia (75.6 (SD 10.7)% and 72.3 (12.8)%, respectively) than with halothane (65.0 (13.1)% and 54.7 (13.9)%, respectively).	Halothane	202-211	microtubule-associated protein 2	Rattus norvegicus	0-4
8123414-0	1993	Flow reversal through a Mark III halothane vaporizer.	Halothane	33-42	microtubule affinity regulating kinase 1	Homo sapiens	24-28
8346202-6	1993	We also found that Shaw2 K+ channels were selectively blocked by halothane (1 mM).	Halothane	65-74	Shaker cognate w	Drosophila melanogaster	19-24
8457242-0	1993	Increasing DNase I activity after exposure of isolated DNA to halothane.	Halothane	62-71	deoxyribonuclease 1	Bos taurus	11-18
8477013-3	1993	A specific antisera, raised against (trifluoroacetamido)lysine adducts formed in vivo after halothane treatment, has previously been used to localize TFEC-derived protein adducts immunohistochemically, and a good correlation between adduction and toxicity was demonstrated.	Halothane	92-101	transcription factor EC	Rattus norvegicus	150-154
8477013-9	1993	Antibodies raised against the halothane metabolite protein adduct (trifluoroacetamido)lysine cross-react with specific mitochondrial proteins from the kidneys of TFEC-treated rats.	Halothane	30-39	transcription factor EC	Rattus norvegicus	162-166
8457242-3	1993	The DNase I activity increased after halothane exposure of the substrate depending on time and doses.	Halothane	37-46	deoxyribonuclease 1	Bos taurus	4-11
7679165-4	1993	Halothane concentration-dependently reduced binding of [3H]quinuclidinylbenzilate ([3H]QNB) to M-cholinoceptors but had no effect on equilibrium saturation binding of 125-iodocyanopindolol (125I]Cyp) to beta-adrenoceptors.	Halothane	0-9	peptidylprolyl isomerase G	Homo sapiens	195-198
8422898-1	1993	Combined perfusion of the neostriatum with 1 nM of cholecystokinin octapeptide (CCK-8) and 0.01, 0.1 or 1 nM of neurotensin was done in the halothane-anesthetized rat after systemic apomorphine treatment (0.05 mg/kg, s.c.).	Halothane	140-149	neurotensin	Rattus norvegicus	112-123
8434746-0	1993	Effects of halothane and isoflurane on beta-endorphin release in children.	Halothane	11-20	proopiomelanocortin	Homo sapiens	39-53
8282226-1	1993	CCl4 and related compounds, such as halothane, are metabolized by the liver to form free radical intermediates, which are thought to be implicated in the hepatotoxic response.	Halothane	36-45	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
8433499-5	1993	Halothane 0.6MAC prolonged PEP, and shortened 1/PEP2 and Pd/ICT.	Halothane	0-9	prolyl endopeptidase	Homo sapiens	27-30
8415876-3	1993	Sera of halothane hepatitis patients contain antibodies directed against some discrete liver trifluoroacetyl (TFA)-protein adducts, which arise upon oxidative biotransformation of halothane and include protein disulfide isomerase, microsomal carboxylesterase, calreticulin, ERp72, GRP 78 and ERp99.	Halothane	8-17	calreticulin	Homo sapiens	260-272
8415876-3	1993	Sera of halothane hepatitis patients contain antibodies directed against some discrete liver trifluoroacetyl (TFA)-protein adducts, which arise upon oxidative biotransformation of halothane and include protein disulfide isomerase, microsomal carboxylesterase, calreticulin, ERp72, GRP 78 and ERp99.	Halothane	8-17	protein disulfide isomerase family A member 4	Homo sapiens	274-279
8415876-3	1993	Sera of halothane hepatitis patients contain antibodies directed against some discrete liver trifluoroacetyl (TFA)-protein adducts, which arise upon oxidative biotransformation of halothane and include protein disulfide isomerase, microsomal carboxylesterase, calreticulin, ERp72, GRP 78 and ERp99.	Halothane	8-17	heat shock protein family A (Hsp70) member 5	Homo sapiens	281-287
1283841-0	1992	Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs.	Halothane	88-97	beta-2 adrenergic receptor	Canis lupus familiaris	10-40
1283841-3	1992	We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs.	Halothane	97-106	beta-2 adrenergic receptor	Canis lupus familiaris	47-66
8457242-6	1993	Therefore, it is possible that halothane exposure induces changes in DNA conformation demonstrable by an increased DNase I activity.	Halothane	31-40	deoxyribonuclease 1	Bos taurus	115-122
1318010-11	1992	It appears that while halothane and isoflurane suppress both IK and ICa, these anesthetics preferentially reduce ICa.	Halothane	22-31	calcium voltage-gated channel subunit alpha1 C	Canis lupus familiaris	61-71
1457743-11	1992	The serum GPT activity was increased by halothane inhalation.	Halothane	40-49	alanine aminotransferase 1	Cavia porcellus	10-13
1642355-0	1992	Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.	Halothane	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
1642355-0	1992	Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.	Halothane	39-48	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
1642355-1	1992	The effects of pentobarbital and halothane anesthesia on the expression in brain of the immediate-early genes c-fos and jun-B were investigated.	Halothane	33-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
1328139-6	1992	In contrast, during halothane anesthesia, the pulmonary vasodilator responses to both bradykinin and nitroprusside were abolished.	Halothane	20-29	kininogen 1	Canis lupus familiaris	86-96
1549932-5	1992	The halothane anesthesia effectively increased the plasma levels of AVP and ANG II, and plasma renin activity without any relation to changes in MSAP.	Halothane	4-13	renin	Ovis aries	95-100
1595065-2	1992	We studied the acute effects of a single dose (50 or 200 micrograms/kg) of intravenous recombinant human TNF alpha (rhTNF alpha) on myocardial function in halothane-anesthetized dogs.	Halothane	155-164	tumor necrosis factor	Homo sapiens	105-114
1594281-1	1992	Lignocaine was tested either alone or in combination with a low dose of morphine by intrathecal administration on the C- and A-beta evoked responses of nociceptive neurones in the dorsal horn of the halothane-anaesthetized rat.	Halothane	199-208	amyloid beta precursor protein	Rattus norvegicus	125-131
1547853-1	1992	The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics.	Halothane	133-142	albumin	Homo sapiens	66-79
1736699-7	1992	In the rostral sections, in the isoflurane- and halothane-normothermia groups, moderate to severe injury was observed in striatum, cerebral cortex, hippocampus (CA1 and CA3 areas), and reticular nucleus of the thalamus (e.g., the median scores for the CA1 area were 3 in both the halothane-hypothermia and the isoflurane-normothermia groups), and there were no differences between the two groups.	Halothane	48-57	carbonic anhydrase 1	Rattus norvegicus	161-164
1736699-7	1992	In the rostral sections, in the isoflurane- and halothane-normothermia groups, moderate to severe injury was observed in striatum, cerebral cortex, hippocampus (CA1 and CA3 areas), and reticular nucleus of the thalamus (e.g., the median scores for the CA1 area were 3 in both the halothane-hypothermia and the isoflurane-normothermia groups), and there were no differences between the two groups.	Halothane	48-57	carbonic anhydrase 3	Rattus norvegicus	169-172
1736699-7	1992	In the rostral sections, in the isoflurane- and halothane-normothermia groups, moderate to severe injury was observed in striatum, cerebral cortex, hippocampus (CA1 and CA3 areas), and reticular nucleus of the thalamus (e.g., the median scores for the CA1 area were 3 in both the halothane-hypothermia and the isoflurane-normothermia groups), and there were no differences between the two groups.	Halothane	48-57	carbonic anhydrase 1	Rattus norvegicus	252-255
1540459-5	1992	Serum AST activity in those patients receiving halothane was increased at 24 h and at 48 h compared with those who received isoflurane (not statistically significant).	Halothane	47-56	solute carrier family 17 member 5	Homo sapiens	6-9
1540459-6	1992	Glutathione S-transferase activity was increased significantly in the halothane group throughout the period of study, compared with those who received isoflurane.	Halothane	70-79	glutathione S-transferase kappa 1	Homo sapiens	0-25
1504264-0	1992	The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane.	Halothane	131-140	calreticulin	Rattus norvegicus	28-40
1307775-0	1992	Changes in human plasma dopamine-beta-hydroxylase activity after ketamine and halothane anesthesia.	Halothane	78-87	dopamine beta-hydroxylase	Homo sapiens	24-49
1836833-1	1991	Halothane, an anesthetic with marked depressant effects on the circulation, was studied for its ability to inhibit inositol phosphate and Ca2+ signaling evoked by the vasoactive hormone arginine vasopressin (AVP) and Ca2+ responses elicited by platelet-derived growth factor and by thapsigargin in cultured A7r5 vascular smooth muscle cells.	Halothane	0-9	arginine vasopressin	Rattus norvegicus	195-206
1354420-0	1992	Multiple restriction fragment length polymorphisms in the porcine calcium release channel gene (CRC): assignment to the halothane (HAL) linkage group.	Halothane	120-129	ryanodine receptor 1	Sus scrofa	96-99
1354420-0	1992	Multiple restriction fragment length polymorphisms in the porcine calcium release channel gene (CRC): assignment to the halothane (HAL) linkage group.	Halothane	131-134	ryanodine receptor 1	Sus scrofa	96-99
1354420-5	1992	Significant evidence for genetic linkage between the CRC1/CRC3 loci and the A1BG locus in the HAL linkage group confirmed a previous assignment of the CRC gene to chromosome 6 in the pig.	Halothane	94-97	alpha-1-B glycoprotein	Sus scrofa	76-80
1729913-1	1992	This study has examined the effect of halothane on the structure and response of isolated cardiac troponin C to Ca2+ and the response of skinned soleus and cardiac muscle fibers to Ca2+.	Halothane	38-47	troponin C1, slow skeletal and cardiac type	Homo sapiens	90-108
1729913-2	1992	The high-affinity Ca(2+)-binding sites of cardiac troponin C were assessed by measurement of the change in intrinsic tyrosine fluorescence and ultraviolet circular dichroism in response to Ca2+ in the presence and absence of halothane.	Halothane	225-234	troponin C1, slow skeletal and cardiac type	Homo sapiens	42-60
1594531-0	1992	Suicidal inactivation of human cytochrome P-450 by carbon tetrachloride and halothane in vitro.	Halothane	76-85	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
1594531-1	1992	A significant loss of human cytochrome P-450 was observed during the anaerobic incubation of NADPH-reduced human liver microsomes obtained from surgical samples, in presence of carbon tetrachloride or halothane.	Halothane	201-210	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-44
1594531-5	1992	The results indicate that human liver cytochrome P-450 can be inactivated reductively in vitro by CCl4 and halothane reactive metabolites and suggest that a suicide type of mechanism, similar to that which was recently demonstrated to occur, for both substrates, with rat liver microsomes (Manno et al.	Halothane	107-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-54
1832279-2	1991	Halothane inhibited the binding of radiolabeled agonists to 5-HT1A and adenosine A1 receptors by up to 30%, but only at concentrations considerably greater than those necessary for the maintenance of the anesthetic state.	Halothane	0-9	5-hydroxytryptamine receptor 1A	Rattus norvegicus	60-66
1786547-6	1991	Postischemic halothane anesthesia during the initial 1.7 h of recirculation abolished subsequent motor hyperactivity and protected 84% of all CA1 neurons.	Halothane	13-22	carbonic anhydrase 1	Homo sapiens	142-145
15278600-9	1991	They also imply that the suppression of production of halothane metabolites is the result of direct enzyme inhibition on cytochrome P-450, since these agents did not affect the activity of fp(2) and fp(1) which are flavoproteins existing in the microsomal electron transport system.	Halothane	54-63	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	121-137
1716078-1	1991	The purpose of this investigation was to determine if alteration in the function of the dihydropyridine receptor may in turn modify halothane-induced contractures in muscle bundles from patients susceptible to malignant hyperthermia (MH).	Halothane	132-141	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	88-112
1716078-6	1991	These results on cut MH-susceptible human muscle bundles support the hypothesis that halothane-induced contracture in MH can be modified by the binding of Ca2+ agonists or antagonists to the dihydropyridine receptor.	Halothane	85-94	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	191-215
1832279-1	1991	The influence of halothane on the interactions of 5-HT1A and adenosine A1 receptors with G proteins was determined by monitoring the guanine nucleotide sensitivity of agonist binding to these receptors.	Halothane	17-26	5-hydroxytryptamine receptor 1A	Rattus norvegicus	50-56
1665792-4	1991	Urethane (5-100 mM), halothane (1-5 mM) and pentobarbitone (0.1-2 mM) showed slight selectivity for the axonal Ca2+ tail.	Halothane	21-30	carbonic anhydrase 2	Rattus norvegicus	111-114
1718937-0	1991	Effects of BAY K 8644, nifedipine, and low Ca2+ on halothane and caffeine potentiation.	Halothane	51-60	carbonic anhydrase 2	Homo sapiens	43-46
1718937-1	1991	The purpose of this investigation was to examine the effects of the Ca2+ agonist BAY K 8644 and the Ca2+ antagonist nifedipine on halothane- and caffeine-induced twitch potentiation of mammalian skeletal muscle.	Halothane	130-139	carbonic anhydrase 2	Homo sapiens	68-71
1718937-1	1991	The purpose of this investigation was to examine the effects of the Ca2+ agonist BAY K 8644 and the Ca2+ antagonist nifedipine on halothane- and caffeine-induced twitch potentiation of mammalian skeletal muscle.	Halothane	130-139	carbonic anhydrase 2	Homo sapiens	100-103
1718937-5	1991	Low Ca2+ significantly depressed twitches by approximately 25% but also inhibited halothane"s inotropic effect.	Halothane	82-91	carbonic anhydrase 2	Homo sapiens	4-7
1718937-8	1991	These results suggest that halothane potentiates twitches via a mechanism that involves or is influenced by extracellular Ca2+.	Halothane	27-36	carbonic anhydrase 2	Homo sapiens	122-125
15278623-4	1991	In each age group, the incidence of opisthotonus occurred in the following order: sevoflurane > isoflurane > enflurane > methoxyflurane > halothane.	Halothane	150-159	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	36-48
15278623-6	1991	Halothane rarely produced opisthotonus.	Halothane	0-9	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	26-38
2043158-7	1991	These results suggest that PB-B is preferentially bound as complex and resistant to inactivation because of complex stability, and that halothane reduction readily destroys the cytochrome P450 form, PB-C.	Halothane	136-145	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	177-192
1906092-8	1991	Halothane (0.5 mM) also inhibited KCl-induced PRL secretion by 50-80% and the corresponding KCl-induced rise in [Ca2+]i by 68 +/- 6%.	Halothane	0-9	prolactin	Rattus norvegicus	46-49
1906092-9	1991	These data indicate that halothane inhibits secretagogue-stimulated PRL secretion by reducing the elevation of [Ca2+]i produced by calcium (Ca2+) influx.	Halothane	25-34	prolactin	Rattus norvegicus	68-71
2043158-7	1991	These results suggest that PB-B is preferentially bound as complex and resistant to inactivation because of complex stability, and that halothane reduction readily destroys the cytochrome P450 form, PB-C.	Halothane	136-145	dihydrolipoamide S-acetyltransferase	Rattus norvegicus	199-203
2031817-10	1991	In the elderly, PE"-Pa for halothane was significantly greater than in the young and than PE"-Pa for isoflurane.	Halothane	27-36	carnosine dipeptidase 2	Homo sapiens	16-22
2043158-0	1991	Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.	Halothane	98-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	31-46
2043158-0	1991	Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.	Halothane	98-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	108-123
2043158-1	1991	The hypothesis that the reduced spectral halothane-cytochrome P450 complex formed in rat hepatic microsomes is a stable cytochrome P450 specific species was examined.	Halothane	41-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-66
2043158-1	1991	The hypothesis that the reduced spectral halothane-cytochrome P450 complex formed in rat hepatic microsomes is a stable cytochrome P450 specific species was examined.	Halothane	41-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	120-135
2043158-4	1991	A large portion of total microsomal cytochrome P450 was destroyed upon halothane reduction (up to 39%), yet the complexed cytochrome P450, particularly in microsomes from PB-treated animals, was resistant to the irreversible inactivation mechanisms of halothane reduction.	Halothane	71-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-51
2043158-4	1991	A large portion of total microsomal cytochrome P450 was destroyed upon halothane reduction (up to 39%), yet the complexed cytochrome P450, particularly in microsomes from PB-treated animals, was resistant to the irreversible inactivation mechanisms of halothane reduction.	Halothane	252-261	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-137
1906092-2	1991	Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.	Halothane	0-9	thyrotropin releasing hormone	Rattus norvegicus	101-130
1906092-2	1991	Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.	Halothane	0-9	thyrotropin releasing hormone	Rattus norvegicus	132-135
1906092-2	1991	Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.	Halothane	0-9	prolactin	Rattus norvegicus	156-159
1906092-3	1991	The sustained (extracellular calcium-dependent) phase of PRL secretion was 70 +/- 7% inhibited by the highest concentration of halothane tested (0.76 mM); 50% inhibition was produced by approximately 0.4 mM halothane.	Halothane	127-136	prolactin	Rattus norvegicus	57-60
1906092-3	1991	The sustained (extracellular calcium-dependent) phase of PRL secretion was 70 +/- 7% inhibited by the highest concentration of halothane tested (0.76 mM); 50% inhibition was produced by approximately 0.4 mM halothane.	Halothane	207-216	prolactin	Rattus norvegicus	57-60
1906092-5	1991	Consistent with these observations, halothane inhibited (IC50 approximately 0.45 mM) the sustained phase of the TRH-induced rise in intracellular calcium ([Ca2+]i) to a greater extent than the initial [Ca2+]i peak.	Halothane	36-45	thyrotropin releasing hormone	Rattus norvegicus	112-115
1920540-2	1991	In this study, we showed that egasyn is identical to one of the carboxylesterase isozymes and organophosphorus and carbamate insecticides, acetanilide which is a specific substrate of egasyn and halothane caused a rapid dissociation of the egasyn-microsomal beta-glucuronidase complex when administered in vivo or when added in vitro to isolated hepatocytes.	Halothane	195-204	carboxylesterase 1	Homo sapiens	30-36
2048706-12	1991	With the respective inhalational agents, Rin increased maximally between 3% (halothane) or 8% (enflurane) and 21% (isoflurane), Rex between 16% (halothane, enflurane) and 29% (isoflurane).	Halothane	77-86	Ras like without CAAX 2	Homo sapiens	41-44
2048706-12	1991	With the respective inhalational agents, Rin increased maximally between 3% (halothane) or 8% (enflurane) and 21% (isoflurane), Rex between 16% (halothane, enflurane) and 29% (isoflurane).	Halothane	145-154	Ras like without CAAX 2	Homo sapiens	41-44
1920540-2	1991	In this study, we showed that egasyn is identical to one of the carboxylesterase isozymes and organophosphorus and carbamate insecticides, acetanilide which is a specific substrate of egasyn and halothane caused a rapid dissociation of the egasyn-microsomal beta-glucuronidase complex when administered in vivo or when added in vitro to isolated hepatocytes.	Halothane	195-204	glucuronidase beta	Homo sapiens	258-276
1986663-2	1991	The current study compared the effects of halothane, enflurane, and isoflurane on resting membrane potential and conductance of hippocampal CA1 neurons in vitro.	Halothane	42-51	carbonic anhydrase 1	Homo sapiens	140-143
1898840-0	1991	Halothane potentiates the antitumor activity of gamma-interferon and mimics calmodulin-blocking agents.	Halothane	0-9	calmodulin 1	Homo sapiens	76-86
1895690-0	1991	[A comparative study of the level of plasma prolactin in women and men undergoing operations under halothane and neuroleptanesthesia].	Halothane	99-108	prolactin	Homo sapiens	44-53
1898840-3	1991	Using the tumor target cell survival (TTCS) assay, concentrations of halothane from 0.5 to 2% markedly augmented the antitumor activities of IFN-gamma against HT-29.	Halothane	69-78	interferon gamma	Homo sapiens	141-150
1898840-4	1991	The tumor cell cytostatic effects of IFN-gamma in the 0.75-6-unit/ml range were increased nearly 400% by concentrations of halothane as low as 1%.	Halothane	123-132	interferon gamma	Homo sapiens	37-46
1898840-5	1991	These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml.	Halothane	107-116	interferon gamma	Homo sapiens	195-204
1898840-5	1991	These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml.	Halothane	107-116	interferon gamma	Homo sapiens	217-226
1898840-6	1991	The cytolytic activity of IFN-gamma was increased nearly 300% by doses of halothane as low as 1%.	Halothane	74-83	interferon gamma	Homo sapiens	26-35
1898840-9	1991	These observations suggest that the pattern of halothane potentiation of the antitumor activity of IFN-gamma is similar to that exhibited by known calmodulin inhibitors.	Halothane	47-56	interferon gamma	Homo sapiens	99-108
1898840-9	1991	These observations suggest that the pattern of halothane potentiation of the antitumor activity of IFN-gamma is similar to that exhibited by known calmodulin inhibitors.	Halothane	47-56	calmodulin 1	Homo sapiens	147-157
2053846-0	1991	The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane.	Halothane	87-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
2053846-1	1991	Anaerobic incubation of NADPH- or sodium dithionite-reduced rat liver microsomes with halothane resulted in a significant inactivation of cytochrome P-450 and parallel loss of the prosthetic group protohaem.	Halothane	86-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	138-154
2053846-3	1991	Cytochrome P-450 loss by halothane was found to be irreversible, saturable, inhibited by carbon monoxide and showed biphasic, pseudo first-order kinetics, thus fulfilling all the conditions of a typical "suicide" inactivation reaction.	Halothane	25-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
2053846-5	1991	A partition ratio, between metabolic turnover of the substrate and enzyme inactivation, of about 121 was found with microsomes from phenobarbital-treated rats, indicating that halothane is rather efficient as a suicide substrate of cytochrome P-450.	Halothane	176-185	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	232-248
2053846-6	1991	A stable complex between reduced cytochrome P-450 and a halothane metabolite is responsible for the 470 nm peak observed in the difference spectrum of reduced liver microsomes obtained on addition of halothane.	Halothane	56-65	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
2053846-6	1991	A stable complex between reduced cytochrome P-450 and a halothane metabolite is responsible for the 470 nm peak observed in the difference spectrum of reduced liver microsomes obtained on addition of halothane.	Halothane	200-209	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
2073584-3	1990	In the halothane-anaesthetized rat, neurotensin, when applied to the ventral tegmental area, stimulated DOPAC production in the ipsilateral nucleus accumbens, while its application to the substantia nigra did not affect striatal DOPAC levels significantly.	Halothane	7-16	neurotensin	Rattus norvegicus	36-47
2240685-2	1990	At 22 degrees C, halothane (greater than 0.46 mM) induced Ca2+ release from the SR of Ca2(+)-loaded skinned fibers that resulted in transient tensions.	Halothane	17-26	carbonic anhydrase 2	Homo sapiens	58-61
2240685-2	1990	At 22 degrees C, halothane (greater than 0.46 mM) induced Ca2+ release from the SR of Ca2(+)-loaded skinned fibers that resulted in transient tensions.	Halothane	17-26	carbonic anhydrase 2	Homo sapiens	86-89
2240685-3	1990	Higher concentrations of halothane (greater than 4.65 mM) reduced the steady-state accumulation of Ca2+ in the SR at 22 degrees C. Cooling (to less than 10 degrees C) elicited transient contractures (cooling-induced contractures [CC]) in Ca2(+)-loaded skinned fibers, despite the fact that the tensions elicited by adding Ca2+ to the bath were depressed at these low temperatures.	Halothane	25-34	carbonic anhydrase 2	Homo sapiens	99-102
2240685-3	1990	Higher concentrations of halothane (greater than 4.65 mM) reduced the steady-state accumulation of Ca2+ in the SR at 22 degrees C. Cooling (to less than 10 degrees C) elicited transient contractures (cooling-induced contractures [CC]) in Ca2(+)-loaded skinned fibers, despite the fact that the tensions elicited by adding Ca2+ to the bath were depressed at these low temperatures.	Halothane	25-34	carbonic anhydrase 2	Homo sapiens	238-241
2240685-3	1990	Higher concentrations of halothane (greater than 4.65 mM) reduced the steady-state accumulation of Ca2+ in the SR at 22 degrees C. Cooling (to less than 10 degrees C) elicited transient contractures (cooling-induced contractures [CC]) in Ca2(+)-loaded skinned fibers, despite the fact that the tensions elicited by adding Ca2+ to the bath were depressed at these low temperatures.	Halothane	25-34	carbonic anhydrase 2	Homo sapiens	238-241
2240685-4	1990	The skinned fibers did not develop CCs at 12-16 degrees C. Halothane cooling contractures could be elicited at these temperatures by exposing the fibers to halothane concentrations that failed to elicit Ca2+ release at 22 degrees C. The halothane cooling contractures were blocked by procaine but not by lidocaine.	Halothane	59-68	carbonic anhydrase 2	Homo sapiens	203-206
2240685-5	1990	It was concluded that these contractures resulted from a synergistic interaction between halothane and cooling that stimulates Ca2+ release from, and reduces Ca2+ uptake by, the sarcoplasmic reticulum.	Halothane	89-98	carbonic anhydrase 2	Homo sapiens	127-130
2240685-5	1990	It was concluded that these contractures resulted from a synergistic interaction between halothane and cooling that stimulates Ca2+ release from, and reduces Ca2+ uptake by, the sarcoplasmic reticulum.	Halothane	89-98	carbonic anhydrase 2	Homo sapiens	158-161
2084456-0	1990	pH-dependent interaction of halothane upon thiopental binding to human serum albumin.	Halothane	28-37	albumin	Homo sapiens	71-84
2084456-1	1990	At pH 7.4 the binding of thiopental to human serum albumin (HSA) was increased in the presence of halothane.	Halothane	98-107	albumin	Homo sapiens	45-58
1895690-6	1991	In women, the rise in plasma prolactin was greater during operations performed under halothane anesthesia and in men--under neuroleptanesthesia.	Halothane	85-94	prolactin	Homo sapiens	29-38
2221441-0	1990	Halothane decreases the release of neuropeptide Y and 3,4-dihydroxyphenylglycol from superfused segments of dog pulmonary artery.	Halothane	0-9	neuropeptide Y	Canis lupus familiaris	35-49
2221441-8	1990	Halothane decreased significantly the rates of NPY and DOPEG efflux during and after 12 Hz ES; DOPEG efflux evoked by 6 Hz stimulation was also decreased by halothane.	Halothane	0-9	neuropeptide Y	Canis lupus familiaris	47-50
2221441-9	1990	The percentage of the total tissue content of NPY that overflowed was decreased by halothane.	Halothane	83-92	neuropeptide Y	Canis lupus familiaris	46-49
2221441-11	1990	These studies provide evidence that halothane slows efflux of NPY that is released along with NE from dog pulmonary artery during high frequencies of stimulation.	Halothane	36-45	neuropeptide Y	Canis lupus familiaris	62-65
2249173-4	1990	The highest linkage disequilibrium was found between Hal-Phi (0.0606) followed by Hal-Pgd (0.0428) and Hal-Po2 (-0.0308).	Halothane	53-56	vasoactive intestinal peptide	Sus scrofa	57-60
2249173-4	1990	The highest linkage disequilibrium was found between Hal-Phi (0.0606) followed by Hal-Pgd (0.0428) and Hal-Po2 (-0.0308).	Halothane	82-85	phosphogluconate dehydrogenase	Sus scrofa	86-89
2249173-4	1990	The highest linkage disequilibrium was found between Hal-Phi (0.0606) followed by Hal-Pgd (0.0428) and Hal-Po2 (-0.0308).	Halothane	82-85	phosphogluconate dehydrogenase	Sus scrofa	86-89
2393132-8	1990	Ryanodine (a blocker of Ca2+ release from the sarcoplasmic reticulum), like halothane, decreased the amplitude of the oscillations, but did not affect overall tension development.	Halothane	76-85	carbonic anhydrase 2	Oryctolagus cuniculus	24-27
2335273-3	1990	unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA.	Halothane	47-56	Uncoordinated protein 79	Caenorhabditis elegans	0-6
2246808-0	1990	[Effects of succinylcholine on serum levels of myoglobin and CK in children under halothane or enflurane anesthesia].	Halothane	82-91	myoglobin	Homo sapiens	47-56
2384885-8	1990	(2) Acid-loaded cells (pHi 6.43 +/- 0.01 in cells) recovered towards neutrality via activation of Na+/H+ exchange (rate 0.47 pH U/min), and halothane inhibited the rate of pHi recovery by 50%.	Halothane	140-149	glucose-6-phosphate isomerase	Rattus norvegicus	23-26
2384885-8	1990	(2) Acid-loaded cells (pHi 6.43 +/- 0.01 in cells) recovered towards neutrality via activation of Na+/H+ exchange (rate 0.47 pH U/min), and halothane inhibited the rate of pHi recovery by 50%.	Halothane	140-149	glucose-6-phosphate isomerase	Rattus norvegicus	172-175
2141969-10	1990	In summary, pseudocholinesterase activity is the major factor influencing mivacurium infusion rate in children during nitrous oxide-narcotic or nitrous oxide-halothane (0.8% end-tidal) anesthesia.	Halothane	158-167	butyrylcholinesterase	Homo sapiens	12-32
2335273-4	1990	unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less sensitive than N2 to IVM and GABA.	Halothane	71-80	Innexin;Innexin unc-9	Caenorhabditis elegans	0-5
2335273-4	1990	unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less sensitive than N2 to IVM and GABA.	Halothane	71-80	Uncoordinated protein 79	Caenorhabditis elegans	61-67
2199373-7	1990	The first disturbances scored were only visible as retardation in the offspring, and occurred after exposure to concentrations of halothane 200-fold (1000 ppm) the MAK-value.	Halothane	130-139	male germ cell-associated kinase	Rattus norvegicus	164-167
2107750-0	1990	Halothane-dependent release of intracellular Ca2+ in blood cells in malignant hyperthermia.	Halothane	0-9	carbonic anhydrase 2	Homo sapiens	45-48
2107750-3	1990	Anesthetic concentrations of halothane in the cell suspension resulted in a rapid increase in [Ca2+]i in cells from both normal and MH humans or pigs.	Halothane	29-38	carbonic anhydrase 2	Homo sapiens	95-98
2107750-5	1990	Removal of extracellular Ca2+ obliterated the delta[Ca2+]i caused by halothane in cells from normal humans or pigs but only decreased by about half the delta[Ca2+]i in cells from MH humans or pigs.	Halothane	69-78	carbonic anhydrase 2	Homo sapiens	25-28
2107750-5	1990	Removal of extracellular Ca2+ obliterated the delta[Ca2+]i caused by halothane in cells from normal humans or pigs but only decreased by about half the delta[Ca2+]i in cells from MH humans or pigs.	Halothane	69-78	carbonic anhydrase 2	Homo sapiens	52-55
2107750-5	1990	Removal of extracellular Ca2+ obliterated the delta[Ca2+]i caused by halothane in cells from normal humans or pigs but only decreased by about half the delta[Ca2+]i in cells from MH humans or pigs.	Halothane	69-78	carbonic anhydrase 2	Sus scrofa	52-55
2107750-8	1990	It is concluded that clinical concentrations of halothane allow influx of Ca2+ in cells from both normal and MH-susceptible individuals but release Ca2+ from intracellular stores selectively in cells from the latter group.	Halothane	48-57	carbonic anhydrase 2	Homo sapiens	74-77
2107750-8	1990	It is concluded that clinical concentrations of halothane allow influx of Ca2+ in cells from both normal and MH-susceptible individuals but release Ca2+ from intracellular stores selectively in cells from the latter group.	Halothane	48-57	carbonic anhydrase 2	Homo sapiens	148-151
2306457-5	1990	At a 2:1 lipid/anesthetic mole ratio, the polar anesthetics, halothane and enflurane, increased the ratio of (P = O stretching band area)/((CH3)3-N+ stretching band area) by 26.3% and 21.1%, respectively, whereas apolar CCl4 increased it 10.5%.	Halothane	61-70	C-C motif chemokine ligand 4	Homo sapiens	220-224
1970169-0	1990	The porcine PHIcDNA linked to the halothane gene detects a HindIII and XbaI RFLP in normal and malignant hyperthermia susceptible pigs.	Halothane	34-43	vasoactive intestinal peptide	Sus scrofa	12-19
2309539-0	1990	Thiopental binding to human serum albumin in the presence of halothane.	Halothane	61-70	albumin	Homo sapiens	28-41
2309539-1	1990	In vitro thiopental binding (substrate concentration 0.04.10(-3) M = 10 micrograms/ml) to 1% human serum albumin (HSA) increased significantly from 40.2% (= control) to 47.3% in the presence of 1.18.10(-3) M = 2.84 vol% halothane.	Halothane	220-229	albumin	Homo sapiens	99-112
2297116-10	1990	The zero-flow pressure intercepts of the P-Q lines for normoxia (3.2 +/- .9 cmH2O) and hypoxia (4.4 +/- 1.1 cmH2O) were significantly decreased after the administration of halothane (1.7 +/- 1.0 cmH2O and 2.6 +/- 1.0 cmH2O, respectively).	Halothane	172-181	troponin T2, cardiac type	Homo sapiens	76-80
2249484-1	1990	In the pig, the linkage group around the halothane gene (HAL), composed of S-GPI-HAL-H-A1BG-PGD, has been assigned to bands p1.2----q2.2 of chromosome 6.	Halothane	41-50	glucose-6-phosphate isomerase	Sus scrofa	77-80
2494251-7	1989	These results suggest that the higher level of halothane-induced hepatic microsomal lipid peroxidation in guinea pigs is due to the large production of radical metabolites resulting from the large amounts of cytochrome P-450, the high activity of NADPH-cytochrome P-450 reductase, and the low concentration of microsomal alpha-tocopherol.	Halothane	47-56	cytochrome P450 3A14	Cavia porcellus	208-224
2165044-1	1990	CD-1 mice infected with a sublethal dose of influenza A virus were anesthetized for 2 h with halothane.	Halothane	93-102	CD1 antigen complex	Mus musculus	0-4
2134674-4	1990	Among important drugs metabolized by CYP2E1 are anesthetic agents such as halothane, the analgesic acetaminophen, and the muscle relaxant chlorzoxazone.	Halothane	74-83	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	37-43
2637243-2	1989	Halothane (CF3CHClBr) is known to undergo oxidative and reductive biotransformation in the hepatic mixed function oxidase system including cytochrome-P450 reductase and cytochrome P450.	Halothane	0-9	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	139-164
2637243-2	1989	Halothane (CF3CHClBr) is known to undergo oxidative and reductive biotransformation in the hepatic mixed function oxidase system including cytochrome-P450 reductase and cytochrome P450.	Halothane	11-20	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	139-164
2557875-1	1989	The effects of the three inhalation anaesthetics enflurane, isoflurane and halothane were tested in vitro on accommodation of rat CA1 neurones.	Halothane	75-84	carbonic anhydrase 1	Rattus norvegicus	130-133
2622522-5	1989	Halothane inhalation caused increases in the concentrations of CCK-8S-LI in the amygdala and hippocampus.	Halothane	0-9	cholecystokinin	Rattus norvegicus	63-66
12106166-1	1989	Halothane-anaesthetized cats were implanted with push-pull cannulae to demonstrate the in vivo release of cholecystokinin-like immunoreactivity (CCK-LI) in the substantia nigra and the ipsilateral caudate nucleus.	Halothane	0-9	cholecystokinin	Felis catus	106-121
34257294-4	2021	Cpd1 reduces resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, suppresses caffeine-induced contracture in skeletal muscle, reduces sarcolemmal cation influx, and prevents or reverses the fulminant MH crisis induced by isoflurane anesthesia and rescues animals from heat stroke caused by environmental heat stress.	Halothane	50-59	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	0-4
2637954-0	1989	Effect of suxamethonium, pancuronium, neostigmine and halothane on serum cholinesterase activity.	Halothane	54-63	butyrylcholinesterase	Homo sapiens	73-87
2637954-4	1989	Halothane reduced Ch E by 7% and 15% at 10 minutes and 24 hours postanesthetic respectively, compared to preinduction levels.	Halothane	0-9	butyrylcholinesterase	Homo sapiens	18-22
2606149-1	1989	Perfusion of the intrathecal space of halothane-anaesthetized rats with artificial cerebro-spinal fluid supplemented with porcine calcitonin (1-10 microM) produced a significant increase (+67-110%) in the spinal release of [Met5]enkephalin-like material.	Halothane	38-47	proenkephalin	Rattus norvegicus	229-239
2749700-3	1989	MHS is controlled by an autosomal Hal locus with two alleles N and n. Only pigs of genotype nn are sensitive to halothane and susceptible to stress.	Halothane	112-121	histidine ammonia-lyase	Sus scrofa	34-37
2730828-0	1989	Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia.	Halothane	85-94	glutathione S-transferase kappa 1	Homo sapiens	49-74
2724511-9	1989	Especially the PEPs during halothane and enflurane at 1.8 MAC (minimum alveolar concentration) were greater than that of isoflurane.	Halothane	27-36	leucine aminopeptidase 3	Homo sapiens	15-19
2539171-2	1989	The present study measured the effects of halothane and methoxyflurane on synaptic facilitation, paired-pulse potentiation, and long-term potentiation (LTP) in CA1 pyramidal neurones of rat hippocampal slices.	Halothane	42-51	carbonic anhydrase 1	Rattus norvegicus	160-163
2494251-7	1989	These results suggest that the higher level of halothane-induced hepatic microsomal lipid peroxidation in guinea pigs is due to the large production of radical metabolites resulting from the large amounts of cytochrome P-450, the high activity of NADPH-cytochrome P-450 reductase, and the low concentration of microsomal alpha-tocopherol.	Halothane	47-56	NADPH--cytochrome P450 reductase	Cavia porcellus	247-279
2912218-3	1989	The results of this study demonstrate that in halothane-anesthetized cats, neurons located in the LH will indeed release CCK-like material after a carbohydrate-protein meal in a time-dependent fashion.	Halothane	46-55	cholecystokinin	Felis catus	121-124
2521280-2	1989	Halothane (1.1% and 2.2% inspired) or fentanyl (50 and 200 micrograms/kg) anesthesia alone produced little change in basal plasma ANP levels but did increase plasma AII levels above unanesthetized baseline concentrations.	Halothane	0-9	angiotensinogen	Rattus norvegicus	165-168
2521280-5	1989	In contrast, during 2.2% halothane anesthesia the increase in plasma ANP produced by volume loading was greater and the decrease in AII was abolished.	Halothane	25-34	angiotensinogen	Rattus norvegicus	132-135
2712378-3	1989	In patients operated on under halothane anesthesia there was a decrease in IgM, IgG and IgA levels.	Halothane	30-39	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	88-91
2680385-1	1989	A variety of organic compounds such as carbon tetrachloride, halothane, gentian violet, and benznidazole are reductively metabolized to free radicals by liver microsomal cytochrome P-450.	Halothane	61-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	170-186
2793514-1	1989	The glucose phosphate isomerase (GPI) locus is closely linked to the halothane sensitivity locus in pig.	Halothane	69-78	glucose-6-phosphate isomerase	Sus scrofa	4-31
2793514-1	1989	The glucose phosphate isomerase (GPI) locus is closely linked to the halothane sensitivity locus in pig.	Halothane	69-78	glucose-6-phosphate isomerase	Sus scrofa	33-36
3145629-3	1988	markedly reduced early increments of plasma enzyme activities (glutamate-pyruvate-transaminase, GPT; sorbitol dehydrogenase, SDH) in a model of halothane-induced liver injury; the most effective dose in this respect (20 micrograms/kg) significantly depressed halothane-induced ethane exhalation indicating in vivo lipid peroxidation.	Halothane	144-153	glutamic--pyruvic transaminase	Rattus norvegicus	96-99
3145629-3	1988	markedly reduced early increments of plasma enzyme activities (glutamate-pyruvate-transaminase, GPT; sorbitol dehydrogenase, SDH) in a model of halothane-induced liver injury; the most effective dose in this respect (20 micrograms/kg) significantly depressed halothane-induced ethane exhalation indicating in vivo lipid peroxidation.	Halothane	144-153	serine dehydratase	Rattus norvegicus	125-128
3171259-2	1988	The combination anaesthesia decreased the DDP-induced lethality (LD50) and toxic side-effects as evidenced by decreased in BUN and diarrhoea at day 5, whereas nembutal anaesthesia increased DDP-induced toxic side-effects at 37 degrees C. The inhalation anaesthetic halothane had only minor influence on these DDP-induced toxicities.	Halothane	265-274	translocase of inner mitochondrial membrane 8A1	Rattus norvegicus	42-45
3142198-0	1988	Suppression of the pressor effect of centrally administered thyrotropin-releasing hormone under halothane, pentobarbital and flunitrazepam anaesthesia.	Halothane	96-105	thyrotropin releasing hormone	Rattus norvegicus	60-89
3169235-0	1988	Resonance Raman study of the cytochrome P-450 LM2-halothane intermediate complex.	Halothane	50-59	cytochrome P450 2B4	Oryctolagus cuniculus	29-49
2900611-9	1988	The double mutant unc-79; unc-80 is more sensitive to halothane, isoflurane, and fluroxene than is either mutant alone.	Halothane	54-63	Uncoordinated protein 79	Caenorhabditis elegans	18-24
2900611-9	1988	The double mutant unc-79; unc-80 is more sensitive to halothane, isoflurane, and fluroxene than is either mutant alone.	Halothane	54-63	Protein unc-80	Caenorhabditis elegans	26-32
3404442-8	1988	The cytochrome P-450 in microsomes from a single human subject metabolized halothane at a rate comparable to that found in microsomes from phenobarbital- and imidazole-pretreated rabbits.	Halothane	75-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-20
3404442-11	1988	Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits.	Halothane	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
3404442-11	1988	Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits.	Halothane	158-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
3404442-12	1988	In conclusion, the oxidation of halothane to trifluoroacetic acid by cytochrome P-450 isozymes 3a and 2 is enhanced markedly by cytochrome b5.	Halothane	32-41	cytochrome P450 2E1	Oryctolagus cuniculus	69-103
2902147-1	1988	We investigated the direct effects of physiological levels of epinephrine on the basal and arginine-stimulated secretion of insulin, glucagon, and somatostatin from the in situ pancreas in halothane-anaesthetized dogs.	Halothane	189-198	insulin	Canis lupus familiaris	124-131
3390202-0	1988	Reductive metabolism of halothane by purified cytochrome P-450.	Halothane	24-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
3390202-1	1988	The reductive metabolism of halothane was determined using purified RLM2, PBRLM4 and PBRLM5 forms of rat liver microsomal cytochrome P-450.	Halothane	28-37	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
3390202-5	1988	PBRLM5 was also the only form to show the development of a complex between halothane and cytochrome P-450.	Halothane	75-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	89-105
3390202-9	1988	These results show that the two-electron reduction of halothane by cytochrome P-450 was catalyzed by the PBRLM5 form and that cytochrome b5 stimulated the transfer of the second electron to halothane through PBRLM5, but not RLM2 or PBRLM4.	Halothane	54-63	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
3390202-9	1988	These results show that the two-electron reduction of halothane by cytochrome P-450 was catalyzed by the PBRLM5 form and that cytochrome b5 stimulated the transfer of the second electron to halothane through PBRLM5, but not RLM2 or PBRLM4.	Halothane	54-63	cytochrome b5 type A	Rattus norvegicus	126-139
3390202-9	1988	These results show that the two-electron reduction of halothane by cytochrome P-450 was catalyzed by the PBRLM5 form and that cytochrome b5 stimulated the transfer of the second electron to halothane through PBRLM5, but not RLM2 or PBRLM4.	Halothane	190-199	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
3390202-9	1988	These results show that the two-electron reduction of halothane by cytochrome P-450 was catalyzed by the PBRLM5 form and that cytochrome b5 stimulated the transfer of the second electron to halothane through PBRLM5, but not RLM2 or PBRLM4.	Halothane	190-199	cytochrome b5 type A	Rattus norvegicus	126-139
3271620-6	1988	Pretreatment of MHS muscle with calmodulin-antagonist drugs potentiated its response to halothane and caffeine.	Halothane	88-97	calmodulin-3	Sus scrofa	32-42
2885175-2	1987	We compared the effects of sympathetic nerve stimulation to that of pancreatic norepinephrine (NE) infusion on pancreatic somatostatin-like immunoreactivity (SLI) and pancreatic polypeptide (PP) secretion in the halothane-anesthetized dog.	Halothane	212-221	pancreatic polypeptide	Canis lupus familiaris	167-189
3417220-5	1988	VIP levels increased intraoperatively in the halothane group from 5.9 +/- 4.6 to 15.3 +/- 5.3 pmol/l.	Halothane	45-54	vasoactive intestinal peptide	Homo sapiens	0-3
3352597-7	1988	However, in the presence of halothane (2.5%, v/v) isoproterenol stimulation of hormone-sensitive lipase was attenuated by 50% to values of 1.06 +/- 0.23 pkat/mg (p less than 0.01, n = 10).	Halothane	28-37	lipase E, hormone sensitive type	Rattus norvegicus	79-103
3352597-9	1988	These studies suggest that halothane impairs the activation of hormone-sensitive lipase by cAMP-dependent protein kinase and in this manner inhibits beta-adrenergic-stimulated lipolysis.	Halothane	27-36	lipase E, hormone sensitive type	Rattus norvegicus	63-87
3375185-7	1988	The localization of halothane metabolites in the upper alimentary and respiratory pathways is correlated to the presence of cytochrome P-450 at these sites.	Halothane	20-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	124-140
3364667-7	1988	In a second series, with 5 subjects, the concentration of halothane, enflurane or isoflurane was first increased to a steady state of MAC 1.0.	Halothane	58-67	integrin subunit alpha M	Homo sapiens	134-139
3207216-1	1988	In pigs, the gene for glucosephosphate isomerase (GPI) is linked to the halothane (HAL) gene which is responsible for malignant hyperthermia (MH).	Halothane	72-81	glucose-6-phosphate isomerase	Sus scrofa	22-48
3207216-1	1988	In pigs, the gene for glucosephosphate isomerase (GPI) is linked to the halothane (HAL) gene which is responsible for malignant hyperthermia (MH).	Halothane	72-81	glucose-6-phosphate isomerase	Sus scrofa	50-53
3207216-1	1988	In pigs, the gene for glucosephosphate isomerase (GPI) is linked to the halothane (HAL) gene which is responsible for malignant hyperthermia (MH).	Halothane	83-86	glucose-6-phosphate isomerase	Sus scrofa	22-48
3207216-1	1988	In pigs, the gene for glucosephosphate isomerase (GPI) is linked to the halothane (HAL) gene which is responsible for malignant hyperthermia (MH).	Halothane	83-86	glucose-6-phosphate isomerase	Sus scrofa	50-53
3689822-0	1987	Modulation of the reductive metabolism of halothane by microsomal cytochrome b5 in rat liver.	Halothane	42-51	cytochrome b5 type A	Rattus norvegicus	66-79
3689822-1	1987	To study the modulation of the reductive metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by microsomal cytochrome b5, formation of 2-chloro-1,1,1-trifluoroethane (CTE) and 2-chloro-1,1-difluoroethylene (CDE), major reduced metabolites of halothane, was analyzed in vivo and in vitro.	Halothane	55-64	cytochrome b5 type A	Rattus norvegicus	120-133
3689822-1	1987	To study the modulation of the reductive metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by microsomal cytochrome b5, formation of 2-chloro-1,1,1-trifluoroethane (CTE) and 2-chloro-1,1-difluoroethylene (CDE), major reduced metabolites of halothane, was analyzed in vivo and in vitro.	Halothane	66-104	cytochrome b5 type A	Rattus norvegicus	120-133
3689822-7	1987	These results suggested that cytochrome b5 enhances the formation ratio of CDE to CTE by stimulating the supply of a second electron to cytochrome P-450, which might reduce radical reactions in the reductive metabolism of halothane.	Halothane	222-231	cytochrome b5 type A	Rattus norvegicus	29-42
3689822-7	1987	These results suggested that cytochrome b5 enhances the formation ratio of CDE to CTE by stimulating the supply of a second electron to cytochrome P-450, which might reduce radical reactions in the reductive metabolism of halothane.	Halothane	222-231	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-152
3434167-8	1987	With halothane, Vc was decreased and t1/2 alpha was shortened.	Halothane	5-14	interleukin 1 receptor like 1	Homo sapiens	37-47
3674476-0	1987	Opisthotonus during exposure to isoflurane, enflurane, and halothane in mice.	Halothane	59-68	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	0-12
2964965-2	1987	Animal data suggest that opiates, halothane anaesthesia and activation of the sympathetic system stimulates release of atrial natriuretic peptide (ANP).	Halothane	34-43	natriuretic peptide A	Homo sapiens	119-145
2964965-2	1987	Animal data suggest that opiates, halothane anaesthesia and activation of the sympathetic system stimulates release of atrial natriuretic peptide (ANP).	Halothane	34-43	natriuretic peptide A	Homo sapiens	147-150
3660410-6	1987	Halothane addition caused 100% hydrolysis of all diacylphosphoglycerides by phospholipase A2, suggesting a mutual potentiation.	Halothane	0-9	phospholipase A2 group IB	Homo sapiens	76-92
3660410-7	1987	The major products of phospholipase A2 activity, arachidonic acid and lysophosphatidylcholine, when exogenously added, also greatly increased hemolysis induced by halothane, with arachidonic acid most closely resembling the synergism observed with phospholipase A2.	Halothane	163-172	phospholipase A2 group IB	Homo sapiens	22-38
3631611-5	1987	There was a significant drop in maternal blood pressure when halothane was administered but uterine blood flow was maintained, 308 ml X min-1 during asphyxia versus 275 ml X min-1 with halothane.	Halothane	61-70	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
3377798-1	1988	Multiple halothane anesthesias (1.25 MAC for 1 hr on 3 alternate days) of male Long-Evans rats initially decreased by up to 30% and subsequently increased to up to 185% liver cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene, 3,4-dichloro-1-nitrobenzene and trans-4-phenyl-3-buten-2-one and glutathione peroxidase activity.	Halothane	9-18	hematopoietic prostaglandin D synthase	Rattus norvegicus	185-210
3377798-10	1988	The ability of halothane to diminish hepatic glutathione S-transferase activity in vivo may in part reflect the time-dependent inhibition of glutathione S-transferase isoenzymes containing the 3- and 4-subunits.	Halothane	15-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	45-70
3377798-10	1988	The ability of halothane to diminish hepatic glutathione S-transferase activity in vivo may in part reflect the time-dependent inhibition of glutathione S-transferase isoenzymes containing the 3- and 4-subunits.	Halothane	15-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	141-166
2837263-2	1988	Halothane (0.25-1.25 vol%) depressed postsynaptic excitability of CA1 pyramidal neurones in response to activation of stratum radiatum synaptic inputs, and concentration-dependent excitatory (0.25-1.25 vol%) and depressant (1.5-2.0 vol%) actions were observed on dentate granule neurone excitability and perforant path evoked synaptic responses.	Halothane	0-9	carbonic anhydrase 1	Homo sapiens	66-69
3354889-0	1988	Halothane decreases albumin and transferrin synthesis: studies in the isolated, perfused rat liver and in the intact rat.	Halothane	0-9	transferrin	Rattus norvegicus	32-43
3354889-1	1988	Isolated perfused rat livers exposed to 1.5% halothane (equivalent to 1.35 MAC) in O2/CO2 or to O2/CO2 alone produced urea, as well as albumin and transferrin (both measured by immunodiffusion), at constant rates during a 4.25-h perfusion.	Halothane	45-54	transferrin	Rattus norvegicus	147-158
3354889-2	1988	Urea production did not differ in the two treatment groups, but halothane depressed albumin and transferrin synthesis 43% and 45%, respectively.	Halothane	64-73	transferrin	Rattus norvegicus	96-107
3128362-4	1988	Neonates given halothane anaesthesia showed decreased hormonal responses to operation, with significant differences between the two groups in the changes in adrenaline, noradrenaline, and cortisol concentrations and the ratio of insulin to glucagon concentration.	Halothane	15-24	insulin	Homo sapiens	229-236
2898328-1	1988	Halothane is reduced to 2-chloro-1,1,1-trifluoroethane (CTE) and 2-chloro-1,1-difluoroethene (CDE) by cytochrome P-450.	Halothane	0-9	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	102-118
3396546-0	1988	Renin-angiotensin-aldosterone system and plasma vasopressin in surgical patients anaesthetized with halothane or isoflurane.	Halothane	100-109	renin	Homo sapiens	0-5
3396546-2	1988	Plasma renin activity rose significantly during both halothane and isoflurane anaesthesia without surgery, and increased further after the commencement of operation.	Halothane	53-62	renin	Homo sapiens	7-12
3396546-4	1988	Plasma vasopressin decreased during halothane and isoflurane anaesthesia to half of the control values, but rose significantly during cholecystectomy.	Halothane	36-45	arginine vasopressin	Homo sapiens	7-18
15235845-5	1988	The percentage incidence of opisthotonus was 93% for sevoflurane, 81% for isoflurane, 64% for enflurane, 17% for methoxyflurane and 2% for halothane.	Halothane	139-148	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	28-40
3345272-0	1988	Plasma glutathione S-transferase concentration as a measure of hepatocellular integrity following a single general anaesthetic with halothane, enflurane or isoflurane.	Halothane	132-141	glutathione S-transferase kappa 1	Homo sapiens	7-32
3345272-1	1988	The plasma concentration of hepatic glutathione S-transferase (GST) was measured in matched groups of patients who received halothane, enflurane or isoflurane anaesthesia for elective minor surgery.	Halothane	124-133	glutathione S-transferase kappa 1	Homo sapiens	63-66
3345272-2	1988	The GST concentrations increased significantly at 3 h after anaesthesia in patients who received halothane or enflurane, but not in patients who were given isoflurane.	Halothane	97-106	glutathione S-transferase kappa 1	Homo sapiens	4-7
3345272-3	1988	A secondary increase in GST concentration, at 24 h, was seen in a small number of individuals who received halothane or enflurane.	Halothane	107-116	glutathione S-transferase kappa 1	Homo sapiens	24-27
3345272-4	1988	Abnormal GST concentrations were found in 50% of patients following halothane anaesthesia, 20% following enflurane and 11% after isoflurane.	Halothane	68-77	glutathione S-transferase kappa 1	Homo sapiens	9-12
3345272-5	1988	The small but significant increases in GST concentrations in patients receiving halothane or enflurane suggests an impairment of hepatocellular integrity following the administration of these anaesthetics.	Halothane	80-89	glutathione S-transferase kappa 1	Homo sapiens	39-42
2965292-0	1988	Cardiovascular effects of intravenous and intracoronary administration of atrial natriuretic peptide in halothane anesthetized dogs.	Halothane	104-113	natriuretic peptide A	Canis lupus familiaris	74-100
20702341-5	1988	The cytochrome P-450 contents of the hepatocytes from phenobarbital-induced rats were decreased by halothane.	Halothane	99-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-20
2889401-0	1987	Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite.	Halothane	23-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-88
2889401-0	1987	Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite.	Halothane	149-158	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-88
2889401-1	1987	The structural similarity of the halothane metabolite, 2-chloro-1,1-difluoroethene (CDE), to haloethenes that are metabolized by and inactivate cytochrome P-450, suggests that CDE may undergo secondary metabolism and degrade these isozymes.	Halothane	33-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160
2889401-3	1987	CDE alone decreased cytochrome P-450 from phenobarbital-treated rats by as much as 37%, but the addition of isoflurane or halothane to incubations containing CDE increased the loss of cytochrome P-450 nearly twofold.	Halothane	122-131	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	184-200
2889401-5	1987	Extrapolation of these results to the clinical situation suggests that the metabolism of CDE produced during halothane anesthesia and the accompanying cytochrome P-450 loss may contribute to the inhibition of drug metabolism produced by halothane.	Halothane	109-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	151-167
2889401-5	1987	Extrapolation of these results to the clinical situation suggests that the metabolism of CDE produced during halothane anesthesia and the accompanying cytochrome P-450 loss may contribute to the inhibition of drug metabolism produced by halothane.	Halothane	237-246	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	151-167
3032266-1	1987	The effects of an inhalation anesthetic, halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on the formation of 5-lipoxygenase metabolites such as leukotriene B4, 5(S)-hydroxyeicosatetraenoic acid (5-HETE), 6-trans-isomers of leukotriene B4 and leukotriene C4 were studied in human leukocytes stimulated with calcium ionophore A23187.	Halothane	41-50	arachidonate 5-lipoxygenase	Homo sapiens	112-126
3608052-3	1987	Halothane caused haemolysis of erythrocytes in an isoosmolar solution, being more potent at 42 degrees C than at 32 degrees C. Haemolysis produced by an hypoosmolar medium or halothane was potentiated by exogenously added phospholipase A2.	Halothane	0-9	phospholipase A2 group IB	Homo sapiens	222-238
3608052-3	1987	Halothane caused haemolysis of erythrocytes in an isoosmolar solution, being more potent at 42 degrees C than at 32 degrees C. Haemolysis produced by an hypoosmolar medium or halothane was potentiated by exogenously added phospholipase A2.	Halothane	175-184	phospholipase A2 group IB	Homo sapiens	222-238
2955804-2	1987	Fentanyl inhibited the increases in circulating beta-endorphin, ACTH, growth hormone, cortisol and glucose concentrations found in the patients receiving halothane.	Halothane	154-163	proopiomelanocortin	Homo sapiens	48-62
3576211-4	1987	Other alleles of unc-79 are also associated with hypersensitivity to halothane.	Halothane	69-78	Uncoordinated protein 79	Caenorhabditis elegans	17-23
3576211-5	1987	A strain with a mutation in a second gene, unc-80, is also hypersensitive to halothane.	Halothane	77-86	Protein unc-80	Caenorhabditis elegans	43-49
3576211-6	1987	Nematodes bearing mutations in both unc-79 and unc-80 are slightly more sensitive to halothane than those bearing only one of these mutations.	Halothane	85-94	Uncoordinated protein 79	Caenorhabditis elegans	36-42
3576211-6	1987	Nematodes bearing mutations in both unc-79 and unc-80 are slightly more sensitive to halothane than those bearing only one of these mutations.	Halothane	85-94	Protein unc-80	Caenorhabditis elegans	47-53
3037746-2	1987	A decrease in the cholinesterase activity is less pronounced than under the halothane action but more than with the diacetylcholine application.	Halothane	76-85	cholinesterase	Oryctolagus cuniculus	18-32
3032266-5	1987	These observations indicate that the inhibitory effect of halothane on the formation of 5-lipoxygenase metabolites in leukocytes is mainly due to the inhibition of arachidonic acid release.	Halothane	58-67	arachidonate 5-lipoxygenase	Homo sapiens	88-102
2882183-0	1987	Hepatic glutathione S-transferase release after halothane anaesthesia: open randomised comparison with isoflurane.	Halothane	48-57	glutathione S-transferase kappa 1	Homo sapiens	8-33
2882183-2	1987	Plasma GST concentrations have been measured by radioimmunoassay in an open randomised study after halothane or isoflurane anaesthesia.	Halothane	99-108	glutathione S-transferase kappa 1	Homo sapiens	7-10
2882183-3	1987	The concentration of GST was significantly increased after anaesthesia in patients who received halothane in 30% oxygen/70% nitrous oxide (n = 37) and in patients who received halothane in 100% oxygen (n = 17).	Halothane	96-105	glutathione S-transferase kappa 1	Homo sapiens	21-24
2882183-3	1987	The concentration of GST was significantly increased after anaesthesia in patients who received halothane in 30% oxygen/70% nitrous oxide (n = 37) and in patients who received halothane in 100% oxygen (n = 17).	Halothane	176-185	glutathione S-transferase kappa 1	Homo sapiens	21-24
3566799-0	1987	Stabilization of the reduced halocarbon-cytochrome P-450 complex of halothane by N-alkanes.	Halothane	68-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-56
3105540-1	1987	This study demonstrates that the exposure of phenobarbitone-treated rats to halothane at an oxygen concentration of either 10% or 14% results in marked decreases in cytochrome P-450 content and aminopyrine demethylase activity in animals sacrificed from 1 to 48 hr post-exposure.	Halothane	76-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	165-181
3105540-5	1987	The results suggest that cytochrome P-450 may catalyse its own inactivation by virtue of greater free radical production under conditions which favour the non-oxygen dependent metabolism of halothane.	Halothane	190-199	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
3105540-6	1987	The impairment in microsomal function as evidenced by decreases in cytochrome P-450 and aminopyrine demethylase activity are considered to occur as a primary consequence of the reductive metabolism of halothane.	Halothane	201-210	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
3660410-10	1987	Dantrolene and mepacrine antagonized the synergism between halothane and phospholipase A2 most likely by reducing the lytic action of halothane in the presence of arachidonic acid.	Halothane	134-143	phospholipase A2 group IB	Homo sapiens	73-89
3662119-5	1987	Since alpha-protease inhibitors show extensive polymorphism and as the gene for postalbumin-2 is closely linked to the halothane sensitivity locus Hal, this method is a useful tool for conducting parentage control and for predicting Hal genotypes of individual pigs.	Halothane	119-128	histidine ammonia-lyase	Sus scrofa	147-150
3662119-5	1987	Since alpha-protease inhibitors show extensive polymorphism and as the gene for postalbumin-2 is closely linked to the halothane sensitivity locus Hal, this method is a useful tool for conducting parentage control and for predicting Hal genotypes of individual pigs.	Halothane	119-128	histidine ammonia-lyase	Sus scrofa	233-236
3790395-6	1986	The three PLA2 inhibitors antagonized halothane-induced contractures of muscle from MH susceptible patients as well as induction of contractures by suxamethonium and halothane.	Halothane	38-47	phospholipase A2 group IB	Homo sapiens	10-14
3790395-6	1986	The three PLA2 inhibitors antagonized halothane-induced contractures of muscle from MH susceptible patients as well as induction of contractures by suxamethonium and halothane.	Halothane	166-175	phospholipase A2 group IB	Homo sapiens	10-14
3790395-7	1986	Pre-exposing preparations that were previously unresponsive to halothane to bee venom PLA2 caused the muscle strips to respond with contractures upon subsequent challenge with halothane, but not with suxamethonium.	Halothane	176-185	phospholipase A2 group IB	Homo sapiens	86-90
3566799-2	1987	Previous studies have shown that halothane forms such a complex with cytochrome P-450, and the result is a strong absorption at 470 nm.	Halothane	33-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-85
3566799-4	1987	Data are presented which show that several organic solvents (C5-C7N-alkanes) will stabilize the complex formed between halothane and cytochrome P-450.	Halothane	119-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	133-149
3566799-7	1987	Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450.	Halothane	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137
3566799-7	1987	Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450.	Halothane	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	202-218
3566799-7	1987	Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450.	Halothane	111-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137
3566799-7	1987	Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450.	Halothane	111-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137
3828110-5	1986	We have shown that the anaesthetic halothane increases [Ca2+]i in isolated lymphocytes from malignant hyperthermia-susceptible humans and pigs but not in the normal counterparts.	Halothane	35-44	carbonic anhydrase 2	Homo sapiens	56-59
3828110-7	1986	The halothane-mediated rise in [Ca2+]i required external Ca2+ and was prevented by nifedipine, an inhibitor of the voltage-sensitive Ca2+ channels of the cell membrane.	Halothane	4-13	carbonic anhydrase 2	Homo sapiens	32-35
3828110-7	1986	The halothane-mediated rise in [Ca2+]i required external Ca2+ and was prevented by nifedipine, an inhibitor of the voltage-sensitive Ca2+ channels of the cell membrane.	Halothane	4-13	carbonic anhydrase 2	Homo sapiens	57-60
3828110-7	1986	The halothane-mediated rise in [Ca2+]i required external Ca2+ and was prevented by nifedipine, an inhibitor of the voltage-sensitive Ca2+ channels of the cell membrane.	Halothane	4-13	carbonic anhydrase 2	Homo sapiens	57-60
3828110-8	1986	In addition, the effect of halothane on the releasable Ca2+ from intracellular stores was determined by measuring the size of the releasable pool before and after addition of the anaesthetic.	Halothane	27-36	carbonic anhydrase 2	Homo sapiens	55-58
3828110-9	1986	After addition of halothane, about 73% of this Ca2+ pool was still available for release by the Ca2+ ionophore ionomycin in cells from normal humans and pigs.	Halothane	18-27	carbonic anhydrase 2	Homo sapiens	47-50
3828110-9	1986	After addition of halothane, about 73% of this Ca2+ pool was still available for release by the Ca2+ ionophore ionomycin in cells from normal humans and pigs.	Halothane	18-27	carbonic anhydrase 2	Homo sapiens	96-99
3828110-10	1986	In contrast, only about 45% of the free Ca2+ in intracellular stores was left after treatment with halothane in cells from malignant hyperthermia-susceptible humans and swine.	Halothane	99-108	carbonic anhydrase 2	Homo sapiens	40-43
3828110-11	1986	These results indicate that halothane acts both at the cell membrane and at intracellular organelles, and that this action results in a net increase in [Ca2+]i in malignant hyperthermia, but not in normal cells.	Halothane	28-37	carbonic anhydrase 2	Homo sapiens	153-156
3729018-8	1986	The large differences among the treatment groups in the rates of fluoride ion generated per nanomole cytochrome P-450 indicate that enzyme induction regimens disproportionately increase those isozymes of hepatic cytochrome P-450 that are not involved with the reductive defluorination of halothane.	Halothane	288-297	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	212-228
3947389-0	1986	The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin.	Halothane	30-39	albumin	Homo sapiens	132-145
3815853-2	1986	Of 20 selected patients, who received halothane for minor urological procedures, 16 showed a small transient rise in GST between 1 h and 3 h after anaesthesia.	Halothane	38-47	glutathione S-transferase kappa 1	Homo sapiens	117-120
2444141-3	1987	In the light of the previously known genetic linkages in these species, this implied: (1) alpha 1B gene is close linked to Phi, Pgd and Hal (halothane sensitivity locus) loci in pigs; and (2) alpha 1B gene is linked to ME1 and Phi loci in horses.	Halothane	141-150	alpha-1-B glycoprotein	Homo sapiens	90-98
3014887-3	1986	Reflex stimulation of the parasympathetic nervous system by 2-deoxy-D-glucose (2-DG) in dogs anesthetized with halothane (0.8%) caused a fourfold increase in plasma PP levels, equivalent to the response in conscious dogs.	Halothane	111-120	pancreatic polypeptide	Canis lupus familiaris	165-167
3014887-5	1986	Bilateral electrical stimulation of the cervical vagi in halothane-anesthetized dogs elicited a sixfold increase in the pancreatic output of PP.	Halothane	57-66	pancreatic polypeptide	Canis lupus familiaris	141-143
3021443-2	1986	ACTH and beta-LPH concentrations in plasma rose significantly (P less than 0.001) during halothane-nitrous oxide anaesthesia.	Halothane	89-98	proopiomelanocortin	Homo sapiens	9-17
3947389-0	1986	The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin.	Halothane	48-57	albumin	Homo sapiens	132-145
3158254-9	1985	min-1 during halothane or isoflurane anesthesia; the requirements during balanced anesthesia were 9.3 +/- 0.8 micrograms .	Halothane	13-22	CD59 molecule (CD59 blood group)	Homo sapiens	0-5
2416545-4	1986	Our data demonstrated 3 major effects of halothane on the SEP: (a) a small but significant decrease in the average amplitude of the first two components (N25 and P30), (b) a significant increase in the average latency of the late positive component (P53) of the wave form, and (c) occasional obliteration of components N25, N40, P53, and N71, but never of P30.	Halothane	41-50	centromere protein V	Homo sapiens	162-165
2416545-4	1986	Our data demonstrated 3 major effects of halothane on the SEP: (a) a small but significant decrease in the average amplitude of the first two components (N25 and P30), (b) a significant increase in the average latency of the late positive component (P53) of the wave form, and (c) occasional obliteration of components N25, N40, P53, and N71, but never of P30.	Halothane	41-50	tumor protein p53	Homo sapiens	250-253
2416545-4	1986	Our data demonstrated 3 major effects of halothane on the SEP: (a) a small but significant decrease in the average amplitude of the first two components (N25 and P30), (b) a significant increase in the average latency of the late positive component (P53) of the wave form, and (c) occasional obliteration of components N25, N40, P53, and N71, but never of P30.	Halothane	41-50	tumor protein p53	Homo sapiens	329-332
2416545-4	1986	Our data demonstrated 3 major effects of halothane on the SEP: (a) a small but significant decrease in the average amplitude of the first two components (N25 and P30), (b) a significant increase in the average latency of the late positive component (P53) of the wave form, and (c) occasional obliteration of components N25, N40, P53, and N71, but never of P30.	Halothane	41-50	centromere protein V	Homo sapiens	356-359
2867213-0	1986	Effect of halothane on myocardial cyclic AMP and cyclic GMP content of mice.	Halothane	10-19	5'-nucleotidase, cytosolic II	Mus musculus	56-59
2867213-1	1986	Halothane, in anesthetic concentrations (0.6-1.8 volumes/100 ml), produced a dose-dependent decrease in myocardial cyclic AMP (cAMP) content and an increase in cyclic GMP (cGMP) content in mice exposed to a continuous flow of the anesthetic carried in air for 15 min.	Halothane	0-9	5'-nucleotidase, cytosolic II	Mus musculus	167-170
22055144-5	1986	Significant increases in the levels of endogenous mitochondrial calmodulin, fatty acids and phospholipase A(2) activity, and Ca(2+) (mitochondrial and sarcoplasmic) are observed in the M. longissimus dorsi of adult halothane-sensitive pigs when compared with either young halothane-sensitive or young and adult halothane-insensitive pigs.	Halothane	215-224	calmodulin-3	Sus scrofa	64-74
22055144-5	1986	Significant increases in the levels of endogenous mitochondrial calmodulin, fatty acids and phospholipase A(2) activity, and Ca(2+) (mitochondrial and sarcoplasmic) are observed in the M. longissimus dorsi of adult halothane-sensitive pigs when compared with either young halothane-sensitive or young and adult halothane-insensitive pigs.	Halothane	272-281	calmodulin-3	Sus scrofa	64-74
22055144-5	1986	Significant increases in the levels of endogenous mitochondrial calmodulin, fatty acids and phospholipase A(2) activity, and Ca(2+) (mitochondrial and sarcoplasmic) are observed in the M. longissimus dorsi of adult halothane-sensitive pigs when compared with either young halothane-sensitive or young and adult halothane-insensitive pigs.	Halothane	272-281	calmodulin-3	Sus scrofa	64-74
4063356-0	1985	Effect of halothane on Ca2+-induced Ca2+ release from sarcoplasmic reticulum vesicles isolated from rat skeletal muscle.	Halothane	10-19	carbonic anhydrase 2	Rattus norvegicus	23-26
4063356-0	1985	Effect of halothane on Ca2+-induced Ca2+ release from sarcoplasmic reticulum vesicles isolated from rat skeletal muscle.	Halothane	10-19	carbonic anhydrase 2	Rattus norvegicus	36-39
4063356-1	1985	Halothane induces the release of Ca2+ from a subpopulation of sarcoplasmic reticulum vesicles that are derived from the terminal cisternae of rat skeletal muscle.	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	33-36
4063356-2	1985	Halothane-induced Ca2+ release appears to be an enhancement of Ca2+-induced Ca2+ release.	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	18-21
4063356-2	1985	Halothane-induced Ca2+ release appears to be an enhancement of Ca2+-induced Ca2+ release.	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	63-66
4063356-2	1985	Halothane-induced Ca2+ release appears to be an enhancement of Ca2+-induced Ca2+ release.	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	63-66
4063356-3	1985	The low-density sarcoplasmic reticulum vesicles which are believed to be derived from nonjunctional sarcoplasmic reticulum lack the capability of both Ca2+-induced and halothane-induced Ca2+ release.	Halothane	168-177	carbonic anhydrase 2	Rattus norvegicus	186-189
4063356-4	1985	Ca2+ release from terminal cisternae vesicles induced by halothane is inhibited by Ruthenium red and Mg2+, and require ATP (or an ATP analogue), KCl (or similar salt) and extravesicular Ca2+.	Halothane	57-66	carbonic anhydrase 2	Rattus norvegicus	0-3
4063356-4	1985	Ca2+ release from terminal cisternae vesicles induced by halothane is inhibited by Ruthenium red and Mg2+, and require ATP (or an ATP analogue), KCl (or similar salt) and extravesicular Ca2+.	Halothane	57-66	carbonic anhydrase 2	Rattus norvegicus	186-189
4096625-0	1985	[Concentrations of the hemoglobin content, hematocrit and the mean corpuscular hemoglobin concentration of the erythrocytes in halothane-sensitive and -resistant swine].	Halothane	127-136	HGB	Sus scrofa	79-89
3903473-0	1985	Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats.	Halothane	80-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	47-63
3903473-7	1985	These results suggest that the CF3COX oxidative metabolite of halothane is so reactive that it binds predominantly to the cytochrome P-450 that produced it.	Halothane	62-71	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
3921666-5	1985	Halothane inhibited the activities of both pyruvate dehydrogenase (14% depression) and ATP-citrate lyase (32% depression).	Halothane	0-9	ATP citrate lyase	Rattus norvegicus	87-104
3946810-7	1986	SAP decreased 30% during isoflurane administration, 25% during halothane, 21% following fentanyl, and 16% following ketamine.	Halothane	63-72	SH2 domain containing 1A	Homo sapiens	0-3
3865740-0	1985	Effect of thiamylal and diazepam on release of myoglobin and creatine phosphokinase by succinylcholine chloride during halothane anesthesia.	Halothane	119-128	myoglobin	Homo sapiens	47-56
3160261-0	1985	Effects of halothane and fentanyl anesthesia on plasma beta-endorphin immunoreactivity during cardiac surgery.	Halothane	11-20	proopiomelanocortin	Homo sapiens	55-69
3160261-2	1985	Plasma levels of beta-endorphin immunoreactivity measured prior to induction, after induction, after intubation, after skin incision, during cardiopulmonary bypass, and on leaving the operating room were significantly higher in patients given halothane during cardiopulmonary bypass and on leaving the operating room than they were in patients given fentanyl.	Halothane	243-252	proopiomelanocortin	Homo sapiens	17-31
3983816-1	1985	The purpose of this study was to investigate the effect of pentobarbital, halothane, and chloralose anesthesia on the endogenous release of cholecystokinin-33 (CCK-33) in dogs prepared with duodenal fistulas.	Halothane	74-83	cholecystokinin	Canis lupus familiaris	140-155
6087064-4	1984	Following administration of the spin-trap, the expired concentration of CF2CHCl and CF3CH2Cl which are the anaerobic metabolites of halothane decreased, but bilious trifluoroacetate which are aerobic did not change.	Halothane	132-141	ATPase H+ transporting accessory protein 1	Homo sapiens	72-75
2994512-3	1985	Anaesthesia in man with halothane and nitrous oxide was found to be associated with a significant increase in plasma ACTH levels and beta-LPH levels.	Halothane	24-33	proopiomelanocortin	Homo sapiens	117-121
2994512-3	1985	Anaesthesia in man with halothane and nitrous oxide was found to be associated with a significant increase in plasma ACTH levels and beta-LPH levels.	Halothane	24-33	proopiomelanocortin	Homo sapiens	133-141
2981490-6	1985	The findings demonstrate that halothane induces microsomal lipid peroxidation at low PO2 and in the presence of particular cytochrome P-450 isoenzymes, and that the halothane-induced lipid peroxidation leads to severe microsomal lesions, as indicated by the loss of glucose-6-phosphatase activity.	Halothane	30-39	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	266-287
2981490-6	1985	The findings demonstrate that halothane induces microsomal lipid peroxidation at low PO2 and in the presence of particular cytochrome P-450 isoenzymes, and that the halothane-induced lipid peroxidation leads to severe microsomal lesions, as indicated by the loss of glucose-6-phosphatase activity.	Halothane	165-174	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	266-287
3832972-5	1985	The order of the three marker loci was confirmed as Phi-Po2-Pgd but the position of Hal with regards to Phi could not be resolved.	Halothane	84-87	vasoactive intestinal peptide	Sus scrofa	104-107
4079263-0	1985	[Changes in the renin-angiotensin-aldosterone system during kidney operations performed under halothane anesthesia and neuroleptanalgesia].	Halothane	94-103	renin	Homo sapiens	16-21
4050136-4	1985	These pathological myophosphorylase reactions were observed in five deceased patients (one independently of anaesthesia after an extended walk) and in 19 pigs (18 times after halothane testing and once in an experimental animal with clinical evidence of the presence of malignant hyperthermia).	Halothane	175-184	glycogen phosphorylase, muscle associated	Homo sapiens	19-35
6088822-0	1984	[Episodic secretion of ACTH during halothane anesthesia and surgery].	Halothane	35-44	proopiomelanocortin	Homo sapiens	23-27
6462329-1	1984	GABA-transaminase has been found to be released from rat brain synaptosomes by halothane in a dose-related manner.	Halothane	79-88	4-aminobutyrate aminotransferase	Rattus norvegicus	0-17
6696254-2	1984	In previous studies they have shown that the halothane-free radical produced by UV-irradiation is identical to that produced during reductive metabolism of halothane by hepatic cytochrome P-450.	Halothane	45-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	177-193
6696254-2	1984	In previous studies they have shown that the halothane-free radical produced by UV-irradiation is identical to that produced during reductive metabolism of halothane by hepatic cytochrome P-450.	Halothane	156-165	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	177-193
6322827-0	1984	Effect of intratracheal lignocaine, halothane and thiopentone on changes in plasma beta-endorphin immunoreactivity in response to tracheal intubation.	Halothane	36-45	proopiomelanocortin	Homo sapiens	83-97
6693952-0	1984	Effects of halothane and fentanyl anesthesia on resistance to reabsorption of CSF.	Halothane	11-20	colony stimulating factor 2	Canis lupus familiaris	78-81
6524710-6	1984	Some differences between genotypes and linkage groups were attributed to phenotypically halothane-positive parents and offspring being genotypically Hal N/n.	Halothane	88-97	histidine ammonia-lyase	Sus scrofa	149-152
6693955-2	1984	The central conduction time (CCT), the time between the N14 peak (recorded at C-2) and the N20 peak (recorded at the cortex) in response to median nerve stimulation, has been found to be increased by administration of halothane, by brain retraction, and by temporary vascular occlusion in some instances.	Halothane	218-227	SS nuclear autoantigen 1	Homo sapiens	56-59
6651874-10	1983	Maximal changes in both the cytochrome P-450 system and in the glutathione detoxification system were required before halothane demonstrated its hepatotoxic effects.	Halothane	118-127	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-44
6146439-5	1984	Lower CS and HAD activities were observed in the halothane sensitive pigs compared with the other pigs.	Halothane	49-58	citrate synthase	Sus scrofa	6-8
6651874-11	1983	Thus, a new balance between cytochrome P-450-dependent bioactivation and glutathione conjugation of halothane may be necessary for the exaggerated hepatotoxicity of halothane seen in hyperthyroid male rats.	Halothane	165-174	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-44
6652012-7	1983	(0.05 MAC) of halothane induced the activity of NADPH-cytochrome-c-reductase in the liver, decreased the concentration of cytochrome P-450 in the kidney and decreased all the enzyme concentrations measured in lung microsomes.	Halothane	14-23	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
6639824-8	1983	Mean halothane vapour uptake at a constant end-tidal concentration of 0.8% was 114 ml min-1 at 1 min, 36 ml min-1 at 5 min, 29 ml min-1 at 10 min and between 22 and 18 ml min-1 at 20-35 min.	Halothane	5-14	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
6137335-0	1983	The release of inorganic fluoride from halothane and halothane metabolites by cytochrome P-450, hemin, and hemoglobin.	Halothane	39-48	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	78-94
6883095-1	1983	Injection of alpha-melanocyte stimulating hormone (alpha-MSH, 0.6-1.2 nmol in 100-300 nl) into the rostral dorsomedial hypothalamic nucleus of the halothane anesthetized rat resulted in a 12% increase in heart rate (41 +/- 4 bpm) which was accompanied by a slight increase in blood pressure (5 +/- 1 mm Hg).	Halothane	147-156	proopiomelanocortin	Rattus norvegicus	13-49
6883095-1	1983	Injection of alpha-melanocyte stimulating hormone (alpha-MSH, 0.6-1.2 nmol in 100-300 nl) into the rostral dorsomedial hypothalamic nucleus of the halothane anesthetized rat resulted in a 12% increase in heart rate (41 +/- 4 bpm) which was accompanied by a slight increase in blood pressure (5 +/- 1 mm Hg).	Halothane	147-156	proopiomelanocortin	Rattus norvegicus	51-60
6137335-0	1983	The release of inorganic fluoride from halothane and halothane metabolites by cytochrome P-450, hemin, and hemoglobin.	Halothane	53-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	78-94
6137335-5	1983	2-Chloro-1,1-difluoroethylene and 2-bromo-1,1-difluoroethylene are metabolized predominantly by oxidative cytochrome P-450 metabolism, while reductive pathways utilizing reduced cytochrome P-450, hemoglobin, or hemin liberate fluoride from halothane.	Halothane	240-249	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	106-122
6137335-5	1983	2-Chloro-1,1-difluoroethylene and 2-bromo-1,1-difluoroethylene are metabolized predominantly by oxidative cytochrome P-450 metabolism, while reductive pathways utilizing reduced cytochrome P-450, hemoglobin, or hemin liberate fluoride from halothane.	Halothane	240-249	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	178-194
6859583-0	1983	Relationship between cerebral blood volume and CSF pressure during anesthesia with halothane or enflurane in dogs.	Halothane	83-92	colony stimulating factor 2	Canis lupus familiaris	47-50
6872091-2	1983	Anaerobic in vitro incubation of microsomes from phenobarbital(PB)-induced rats with halothane results in an irreversible decrease of measurable cytochrome P-450.	Halothane	85-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	145-161
6872091-5	1983	Aerobic incubation with halothane results in a decrease of cytochrome P-450 which can be completely reversed by dialysis or the addition of potassium ferricyanide.	Halothane	24-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-75
6305176-2	1983	Recently, halothane, an inhalational anesthetic, was shown to inhibit neutrophil bactericidal mechanisms, the center of which is the reaction of myeloperoxidase with H2O2 and Cl.	Halothane	10-19	myeloperoxidase	Homo sapiens	145-160
6340406-0	1983	Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats.	Halothane	67-76	renin	Rattus norvegicus	23-28
6340406-9	1983	During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals.	Halothane	7-16	renin	Rattus norvegicus	41-46
6340406-11	1983	The results suggest that the renin-angiotensin system is important in maintaining blood pressure in halothane anaesthesia, and that the tolerance to haemorrhagic shock is particularly impaired by drugs inhibiting the renin-angiotensin system.	Halothane	100-109	renin	Rattus norvegicus	29-34
6846783-0	1983	[Metabolism of halothane in rats with CCl4-alcohol-induced liver fibrosis].	Halothane	15-24	C-C motif chemokine ligand 4	Rattus norvegicus	38-42
6846783-6	1983	In rats with CCl4-ethanol-induced liver fibrosis and steatosis this elimination half-life was prolonged to 1.24 (1.07-1.41) h indicating an impaired metabolic degradation of halothane in these rats.	Halothane	174-183	C-C motif chemokine ligand 4	Rattus norvegicus	13-17
7109827-1	1982	Exposure of rats to the volatile anesthetics, halothane, enflurane and isoflurane and low FIO2 (0.8%) for two hours results in a transient induction of ODC appearing maximally four hours after exposure.	Halothane	46-55	ornithine decarboxylase 1	Rattus norvegicus	152-155
7109827-3	1982	The concentration of anesthetic used to produce the ODC induction were 0.5% halothane, 1.5% enflurane and 1.4% isoflurane.	Halothane	76-85	ornithine decarboxylase 1	Rattus norvegicus	52-55
7110119-0	1982	Reductive metabolism of halothane by human and rabbit cytochrome P-450.	Halothane	24-33	cytochrome P-450	Oryctolagus cuniculus	54-70
6805483-0	1982	Thyroliberin (thyrotropin releasing hormone): antagonism of halothane and hexobarbital narcosis in mice.	Halothane	60-69	thyrotropin releasing hormone	Mus musculus	0-43
6805483-2	1982	The effect of L-pyroglutamyl-L-histidyl-L-prolinamide (thyroliberin, thyrotropin releasing hormone, TRH) on halothane and hexobarbital narcosis was investigated in mice and compared with pentetrazol, caffeine, d-amphetamine and adrenaline.	Halothane	108-117	thyrotropin releasing hormone	Mus musculus	69-98
6805483-3	1982	TRH shortened dose-dependently the halothane and hexobarbital sleeping-time with ED50 values of 3.1 and 6.6 mg/kg s.c., respectively.	Halothane	35-44	thyrotropin releasing hormone	Mus musculus	0-3
7106207-5	1982	Plasma VP concentration was undetectable in the old intact rats and it rose to the levels of intact young or adult rats during halothane anesthesia.	Halothane	127-136	arginine vasopressin	Rattus norvegicus	7-9
6279900-0	1981	[Effects of intrathecal beta-endorphin and morphine on endocrine response during halothane anesthesia and surgery in man (author"s transl)].	Halothane	81-90	proopiomelanocortin	Homo sapiens	24-38
7168423-0	1982	[Influence of fluothane anesthesia on the human ERG].	Halothane	14-23	ETS transcription factor ERG	Homo sapiens	48-51
6128067-6	1982	A positive correlation was found between mean arterial pressure and vasopressin only in the halothane group.	Halothane	92-101	arginine vasopressin	Homo sapiens	68-79
7139395-0	1982	Arginine vasopressin response to anaesthesia produced by halothane, enflurane and isoflurane.	Halothane	57-66	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	0-20
7139395-3	1982	Ten rabbits were studied to determine the response of plasma AVP to a predetermined time/concentration "dose" of halothane, enflurane or isoflurane.	Halothane	113-122	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	61-64
7039418-7	1982	We conclude the Fortec vaporizer is as efficient in delivering isoflurane in O2 as previous reports have shown the Fluotec Mark III to be in its delivery of halothane.	Halothane	157-166	microtubule affinity regulating kinase 1	Homo sapiens	123-127
7082999-1	1982	Tooth pulp stimulation in halothane-anaesthetized cats induced a long lasting (greater than or equal to 3 h) increase in the levels of Met-enkephalin-like material (MELM) in the cisternal CSF.	Halothane	26-35	granulocyte-macrophage colony-stimulating factor	Felis catus	188-191
6175808-1	1982	Acute hypovolemia induced by bleeding (5 ml/300 g body weight) halothane-anesthetized (0.8% in oxygen) rats is attended by hypotension, bradycardia, and increases in plasma renin, vasopressin, and catecholamine levels.	Halothane	63-72	renin	Rattus norvegicus	173-178
7171127-3	1982	Crossing-over frequencies of 0.05 +/- 0.04, 0.05 +/- 0.03 and 0.1 +/- 0.03 were established between Phi and Hal, H and Hal, and Phi and H respectively.	Halothane	108-111	glucose-6-phosphate isomerase	Sus scrofa	100-103
7171127-3	1982	Crossing-over frequencies of 0.05 +/- 0.04, 0.05 +/- 0.03 and 0.1 +/- 0.03 were established between Phi and Hal, H and Hal, and Phi and H respectively.	Halothane	119-122	glucose-6-phosphate isomerase	Sus scrofa	100-103
7121136-4	1982	Halothane and hexobarbitone also inhibited mitochondrial Ca2+ uptake in vivo.	Halothane	0-9	carbonic anhydrase 2	Rattus norvegicus	57-60
7325344-4	1981	The perioperative control of plasma-ADH levels demonstrated a smaller increase in group 1 (PDA/NLA) compared to group 2 (Halothane), thus implicating a better attenuation of stress and pain.	Halothane	121-130	arginine vasopressin	Homo sapiens	36-39
6340406-11	1983	The results suggest that the renin-angiotensin system is important in maintaining blood pressure in halothane anaesthesia, and that the tolerance to haemorrhagic shock is particularly impaired by drugs inhibiting the renin-angiotensin system.	Halothane	100-109	renin	Rattus norvegicus	217-222
6797886-0	1981	[Effect of halothane and enflurane general anesthesia on adenosine deaminase activity in human lymphocytes].	Halothane	11-20	adenosine deaminase	Homo sapiens	57-76
7020889-7	1981	These findings suggest that insulin secretion in response to hyperglycaemia is stimulated by spinal analgesia and thiopentone anaesthesia, depressed by halothane and enflurane anaesthesia and unchanged during neuroleptanesthesia.	Halothane	152-161	insulin	Canis lupus familiaris	28-35
7330846-0	1981	HLA A and B locus antigens in patients with unexplained hepatitis following halothane anaesthesia.	Halothane	76-85	major histocompatibility complex, class I, A	Homo sapiens	0-11
7330846-1	1981	HLA A and B locus antigens were determined in 17 patients who had recovered from unexplained hepatitis following halothane anaesthesia.	Halothane	113-122	major histocompatibility complex, class I, A	Homo sapiens	0-11
6999007-3	1980	In 8 patients studied during halothane inhalation anesthesia before operation, the acute insulin response (AIR) to glucose (5 g, IV) fell to 51 +/- 3% of the preanesthesia AIR (mean +/- SEM; P < 0.001).	Halothane	29-38	insulin	Homo sapiens	89-96
6796087-0	1981	1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.	Halothane	54-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-89
7293219-8	1981	Dehalogenation of enflurane, which is the preferred pathway, is affected to the same extent as the cytochrome P-450-dependent hydroxylation of halothane and the O-dealkylation of methoxyflurane.	Halothane	143-152	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	99-115
6268859-0	1981	[Effects of halothane anesthesia, epidural anesthesia and surgery on plasma beta-endorphin levels in man (author"s transl)].	Halothane	12-21	proopiomelanocortin	Homo sapiens	76-90
6258757-11	1981	It is concluded therefore that although halothane anesthesia slightly depressed the short latency response component (E1a) exhibiting highly sensory properties, its main effect was to depress the longer latency excitatory components (E1b and E2) which exhibited relatively "nonspecific" properties.	Halothane	40-49	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	118-121
7448097-2	1980	We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule.	Halothane	50-59	nuclear factor kappa B subunit 1	Homo sapiens	34-37
7448097-2	1980	We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule.	Halothane	174-183	nuclear factor kappa B subunit 1	Homo sapiens	34-37
7448097-3	1980	The effect of halothane on P50 was independent of pH between 7.0 and 8.0 and of chloride concentration between 10 and 100 mmol litre-1.	Halothane	14-23	nuclear factor kappa B subunit 1	Homo sapiens	27-30
7007683-0	1980	[Influence of halothane anesthesia and surgery on plasma levels of aldosterone and renin activity in pediatric patients (author"s transl)].	Halothane	14-23	renin	Homo sapiens	83-88
7463707-0	1980	[Serum myoglobin levels following administration of succinylcholine during nitrous oxide-oxygen-halothane anesthesia (author"s transl)].	Halothane	96-105	myoglobin	Homo sapiens	7-16
7428118-0	1980	Quantum chemical studies of anaerobic reductive metabolism of halothane by cytochrome P-450.	Halothane	62-71	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-91
7428118-6	1980	Moreover, when bound as an axial ligand to the iron atom at the heme site in cytochrome P-450, a carbene complex is formed which gives calculated spectral characteristics consistent with those observed when excess halothane is added to reduced cytochrome P-450 or rat liver microsomes under anaerobic conditions.	Halothane	214-223	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
7428118-6	1980	Moreover, when bound as an axial ligand to the iron atom at the heme site in cytochrome P-450, a carbene complex is formed which gives calculated spectral characteristics consistent with those observed when excess halothane is added to reduced cytochrome P-450 or rat liver microsomes under anaerobic conditions.	Halothane	214-223	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	244-260
7382102-0	1980	[Effects of halothane anesthesia and surgery on plasma prolactin levels in man (author"s transl)].	Halothane	12-21	prolactin	Homo sapiens	55-64
7189100-0	1980	Effect of various carrier gases on the halothane output of the Fluotec Mark 3 vaporizer.	Halothane	39-48	microtubule affinity regulating kinase 3	Homo sapiens	71-77
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Halothane	132-141	microtubule affinity regulating kinase 2	Homo sapiens	142-148
7352670-1	1980	The role of the renin--angiotensin system in the maintenance of blood pressure during halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension was evaluated.	Halothane	86-95	renin	Rattus norvegicus	16-21
7352670-8	1980	This demonstrates the participation of the renin--angiotensin system in antagonizing the combined hypotensive effects of halothane and SNP.	Halothane	121-130	renin	Rattus norvegicus	43-48
7436052-0	1980	Halothane sensitivity and linkage of genes for H red blood cell antigens, phosphohexose isomerase (PHI) and 6-phosphogluconate dehydrogenase (6-PGD) variants in pigs.	Halothane	0-9	glucose-6-phosphate isomerase	Sus scrofa	74-97
7436052-0	1980	Halothane sensitivity and linkage of genes for H red blood cell antigens, phosphohexose isomerase (PHI) and 6-phosphogluconate dehydrogenase (6-PGD) variants in pigs.	Halothane	0-9	glucose-6-phosphate isomerase	Sus scrofa	99-102
7189100-1	1980	The carrier gases--air, nitrous oxide/oxyten (50%/50%), and nitrous oxide (100%)--decreased the halothane output from Fluotec Mark 3 vaporizers an average of 87.9%, 85.4%, and 70.9%, respectively, as compared with the halothane output when oxygen was used as the carrier gas.	Halothane	96-105	microtubule affinity regulating kinase 3	Homo sapiens	126-132
294268-1	1979	Perfused livers isolated from rats under halothane anaesthesia produced greater amounts of bile, released smaller amounts of aspartate aminotransferase, and had a much greater ability to maintain a constant concentration of glucose in perfusates than those obtained with ether or pentobarbitone.	Halothane	41-50	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	125-151
6997939-0	1980	[Effects of halothane on the activity of plasmatic renin in the decerebrate cat].	Halothane	12-21	renin	Homo sapiens	51-56
526379-4	1979	There was a greater frequency of increased enzymatic activity following repeat administrations of halothane than following enflurane and the average alanine aminotransferase and gamma glutamyl transpeptidase concentrations were increased to a greater degree following halothane than enflurane.	Halothane	268-277	glutamic--pyruvic transaminase	Homo sapiens	149-173
484893-8	1979	These results support the authors" hypothesis that halothane is metabolized to hepatotoxic intermediates by a reductive or non-oxygen-dependent cytochrome P-450-dependent pathway.	Halothane	51-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160
526379-4	1979	There was a greater frequency of increased enzymatic activity following repeat administrations of halothane than following enflurane and the average alanine aminotransferase and gamma glutamyl transpeptidase concentrations were increased to a greater degree following halothane than enflurane.	Halothane	268-277	inactive glutathione hydrolase 2	Homo sapiens	178-207
526379-6	1979	Change in alanine aminotransferase, lactate dehydrogenase and gamma glutamyl transpeptidase occured more frequently in obese patients receiving halothane.	Halothane	144-153	glutamic--pyruvic transaminase	Homo sapiens	10-34
526379-6	1979	Change in alanine aminotransferase, lactate dehydrogenase and gamma glutamyl transpeptidase occured more frequently in obese patients receiving halothane.	Halothane	144-153	inactive glutathione hydrolase 2	Homo sapiens	62-91
110178-0	1979	A possible interaction of PCB and halothane in man.	Halothane	34-43	pyruvate carboxylase	Homo sapiens	26-29
262774-0	1979	A study on the antemortem detection of PSE muscle in pigs by a halothane test, plasma creatine phosphokinase activities and blood lactate values.	Halothane	63-72	PSE	Sus scrofa	39-42
459413-7	1979	Halothane plus nitrous oxide produced an increase in plasma renin activity, which then subsided to normal by 210 minutes following anesthesia; breathing room air did not result in increases in plasma renin activity.	Halothane	0-9	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	60-65
441024-0	1979	[Aspartate and alanine aminotransferase activity in early postoperative period in patients receiving general anesthesia with halothane and other anesthetics].	Halothane	125-134	glutamic--pyruvic transaminase	Homo sapiens	15-39
35043-2	1979	However, blood pressure decreases when an angiotensin II antagonist, saralasin, is administered during halothane or enflurane anesthesia, but not  during ketamine or fluroxene anesthesia.	Halothane	103-112	angiotensinogen	Rattus norvegicus	42-56
434454-1	1979	Centrilobular necrosis and a ten-fold elevation in serum alanine amino-transferase (ALT) consistently followed 2 hours of 1% halothane anaesthesia in an animal model.	Halothane	125-134	glutamic--pyruvic transaminase	Homo sapiens	57-82
434454-1	1979	Centrilobular necrosis and a ten-fold elevation in serum alanine amino-transferase (ALT) consistently followed 2 hours of 1% halothane anaesthesia in an animal model.	Halothane	125-134	glutamic--pyruvic transaminase	Homo sapiens	84-87
762663-8	1979	Plasma renin concentration increased after halothane.	Halothane	43-52	renin	Homo sapiens	7-12
571219-8	1979	A similar mechanism has been proposed to explain increased halothane concentrations delivered by Fluotec Mark 2 vaporizers in the presence of nitrous oxide.	Halothane	59-68	microtubule affinity regulating kinase 2	Homo sapiens	105-111
761116-4	1979	Halothane administration resulted in an increased slope of PVR against oxygen saturation due to the fact that reduction in cardiac output exceeded the reduction in Ppa.	Halothane	0-9	PVR cell adhesion molecule	Canis lupus familiaris	59-62
761116-5	1979	An analysis of variance showed that it was possible to predict accurately the hypoxic PVR and Ppa responses under halothane anaesthesia from the control hypoxic responses.	Halothane	114-123	PVR cell adhesion molecule	Canis lupus familiaris	86-89
727414-3	1978	The results showed that the increases in blood glucose, plasma cortisol and growth hormone concentrations observed in the halothane group of patients were abolished in those who received fentanyl.	Halothane	122-131	growth hormone 1	Homo sapiens	76-90
667675-1	1978	A case report is presented demonstrating the beneficial beta2 stimulating effect of halothane in a patient with status asthmaticus unresponsive to adequate conventional therapy.	Halothane	84-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	56-61
210335-3	1978	It is suggested that halothane in clinical concentrations neither disturbs the function of microfilaments, essential for E and EA rosette formation, nor affects the metabolism of cyclic AMP in unstimulated human lymphocytes.	Halothane	21-30	adenine phosphoribosyltransferase	Homo sapiens	186-189
646150-4	1978	Microsomal cytochrome P450 and cytochrome b5 decreased after halothane anesthesia (by 7 to 20 per cent of control).	Halothane	61-70	cytochrome b5 type A	Rattus norvegicus	31-44
646151-8	1978	By contrast, the response to vasopressin decreased (from 42.4 +/- 5.7 to 1.0 +/- 6 per cent; P less than 0.001) with halothane.	Halothane	117-126	arginine vasopressin	Rattus norvegicus	29-40
646151-9	1978	The precise mechanism(s) underlying the described hypersensitivity to NE and hyposensitivity to vasopressin in the same vascular structure during halothane anesthesia remains undetermined.	Halothane	146-155	arginine vasopressin	Rattus norvegicus	96-107
277090-3	1978	Ad 2) Drug reactions may be fatal (e.g. halothane), of limited clinical importance (e.g. clorpromazin) or clinically insignificant (e.g. iopanoic acid).	Halothane	40-49	apolipoprotein E	Homo sapiens	0-4
104186-4	1978	A combination of halothane anesthesia and immobilization for 30 or 60 min produced significantly greater increases in Prl levels than immobilization alone for similar periods of time.	Halothane	17-26	prolactin	Macaca mulatta	118-121
909072-0	1977	The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450.	Halothane	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	100-116
909072-0	1977	The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450.	Halothane	38-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	100-116
909072-1	1977	Incubation of halothane with rabbit liver microsomes in the presence of NADPH and oxygen resulted in the formation of trifluoroacetic acid (TFAA).	Halothane	14-23	2,4-dienoyl-CoA reductase 1	Homo sapiens	72-77
599635-0	1977	[The effect of halothane and ether anesthesia, and surgery on plasma ADH levels and renal function (author"s transl)].	Halothane	15-24	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	69-72
593811-0	1977	Close linkage established between the HAL locus for halothane sensitivity and the PHI (phosphohexose isomerase) locus in pigs of the Danish Landrace breed.	Halothane	52-61	histidine ammonia-lyase	Sus scrofa	38-41
328188-0	1977	The effects of halothane on plasma vasopressin during cardio-pulmonary bypass.	Halothane	15-24	arginine vasopressin	Homo sapiens	35-46
856877-1	1977	As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis.	Halothane	105-114	macrophage migration inhibitory factor	Homo sapiens	115-118
856877-3	1977	The halothane-MIF test was positive in four of the five patients with halothane-induced hepatitis; the negative result was in a patient on steroid treatment.	Halothane	4-13	macrophage migration inhibitory factor	Homo sapiens	14-17
856877-3	1977	The halothane-MIF test was positive in four of the five patients with halothane-induced hepatitis; the negative result was in a patient on steroid treatment.	Halothane	70-79	macrophage migration inhibitory factor	Homo sapiens	14-17
856877-5	1977	Our findings suggest that the halothane-MIF test may be of value in the diagnosis of halothane-induced hepatitis and as a screeening procedure for the identification of susceptible subjects.	Halothane	30-39	macrophage migration inhibitory factor	Homo sapiens	40-43
856877-5	1977	Our findings suggest that the halothane-MIF test may be of value in the diagnosis of halothane-induced hepatitis and as a screeening procedure for the identification of susceptible subjects.	Halothane	85-94	macrophage migration inhibitory factor	Homo sapiens	40-43
612115-3	1977	In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished.	Halothane	43-52	butyrylcholinesterase	Homo sapiens	58-78
13202-1	1977	The effects of four commonly used halogenated anesthetic agents (methoxyflurane, halothane, enflurane and fluroxene) on rho-aminohippurate (PAH) uptake by rabbit renal cortical slices were examined.	Halothane	81-90	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	140-143
4324500-0	1970	Plasma levels of ACTH and cortisol in man during halothane anesthesia and surgery.	Halothane	49-58	proopiomelanocortin	Homo sapiens	17-21
943990-5	1976	However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP2 and ejection fraction.	Halothane	9-18	prolyl endopeptidase	Homo sapiens	188-191
1259897-0	1976	Proceedings: The influence of halothane on plasma vasopressin concentrations during cardiopulmonary bypass.	Halothane	30-39	arginine vasopressin	Homo sapiens	50-61
995273-0	1976	[Activity of UDPG in liver steatosis due to fluothane].	Halothane	44-53	UDP-glucose pyrophosphorylase 2	Homo sapiens	13-17
2027-3	1975	Plasma renin activity increased significantly during halothane anaesthesia alone whereas the surgical manipulations did not further influence mean values significantly.	Halothane	53-62	renin	Homo sapiens	7-12
1147200-10	1975	CCl4 occupies a middle position between chloroform and halothane.	Halothane	55-64	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
1115360-8	1975	This supports evidence suggesting that halothane blocks electron transport in the NADH-coenzyme Q reductase level.	Halothane	39-48	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	82-107
1117426-0	1975	Interaction between halothane and propranolol on oxytocin-induced uterine contractions.	Halothane	20-29	oxytocin/neurophysin I prepropeptide	Homo sapiens	49-57
1117426-1	1975	Halothane and other volatile anesthetics were found to relax uteri maximally contracted by oxytocin and to enhance the relaxant effect of propranolol and other agents (tetracaine, quinidine and chlorpromazine) with local anesthetic properties.	Halothane	0-9	oxytocin/neurophysin I prepropeptide	Homo sapiens	91-99
1111363-0	1975	Halothane inhibition of rna and protein synthesis of PHA-treated human lymphocytes.	Halothane	0-9	lamin B receptor	Homo sapiens	53-56
1111363-3	1975	The increased rates of RNA and protein synthesis six and 16 hours after PHA ADDITION WERE INHIBITED BY THE HALOTHANE, MODESTLY AT SIX HOURS AND STRIKINGLY AT 16 HOURS.	Halothane	107-116	lamin B receptor	Homo sapiens	72-75
4142044-1	1974	The behaviour of the CSF cells during gas encephalography (GEG) with O(2), N(2)O, and halothane is poorly known in cerebral developmental disorders.	Halothane	86-95	colony stimulating factor 2	Homo sapiens	21-24
4718247-0	1973	Administration of halothane in the 0-0.5 per cent concentration range with the Fluotec Mark 2 and Mark 3 vaporizers.	Halothane	18-27	microtubule affinity regulating kinase 3	Homo sapiens	98-104
4265360-0	1973	Myosin conformation and enzymatic activity: effect of chloroform, diethyl ether and halothane on optical rotatory dispersion and APTase.	Halothane	84-93	myosin heavy chain 14	Homo sapiens	0-6
5059110-0	1972	Fluotec Mark 2 halothane output: nonlinearity from "off" to 0.5 per cent dial settings.	Halothane	15-24	microtubule affinity regulating kinase 2	Homo sapiens	8-14
5568139-0	1971	The effect of nitrous oxide on halothane output from Fluotec Mark 2 vaporizers.	Halothane	31-40	microtubule affinity regulating kinase 2	Homo sapiens	61-67
5089936-0	1971	Effects of halothane anaesthesia and surgery on human growth hormone and insulin levels in plasma.	Halothane	11-20	growth hormone 1	Homo sapiens	54-68
5089936-0	1971	Effects of halothane anaesthesia and surgery on human growth hormone and insulin levels in plasma.	Halothane	11-20	insulin	Homo sapiens	73-80
4398305-0	1971	Decrease in reduced glutathione and NADPH and inhibition of glucose-6-phosphate dehydrogenase activity caused by metabolites of fluroxene and halothane.	Halothane	142-151	glucose-6-phosphate dehydrogenase	Homo sapiens	60-93
973690-9	1976	In the absence of transient ischemia during occlusion (that is, rCBF greater than 18 ml/100 g/min), halothane and enflurane anesthesia were associated with significantly higher rCBF"s and lower stump pressures than was neuroleptanesthesia.	Halothane	100-109	CCAAT/enhancer binding protein zeta	Rattus norvegicus	64-68
973690-9	1976	In the absence of transient ischemia during occlusion (that is, rCBF greater than 18 ml/100 g/min), halothane and enflurane anesthesia were associated with significantly higher rCBF"s and lower stump pressures than was neuroleptanesthesia.	Halothane	100-109	CCAAT/enhancer binding protein zeta	Rattus norvegicus	177-181
973690-10	1976	Pre-occlusion and post-occlusion rCBF measurements also demonstrated cerebral vasodilation by halothane and enflurane (halothane greater than enflurane) and vasoconstriction by neuroleptanesthesia.	Halothane	94-103	CCAAT/enhancer binding protein zeta	Rattus norvegicus	33-37
973690-10	1976	Pre-occlusion and post-occlusion rCBF measurements also demonstrated cerebral vasodilation by halothane and enflurane (halothane greater than enflurane) and vasoconstriction by neuroleptanesthesia.	Halothane	119-128	CCAAT/enhancer binding protein zeta	Rattus norvegicus	33-37
184113-2	1976	We have observed that three general anesthetic agents of clinical importance, the gases methoxyflurane and halothane and the ultrashortacting barbiturate methohexital, reversibly inhibit vasopressin-stimulated water flow, but do not depress permeability to urea, or the the lipophilic solute diphenylhydantoin.	Halothane	107-116	arginine vasopressin	Homo sapiens	187-198
987723-1	1976	Massive myoglobinuria developed in a patient given halothane and IV succinylcholine, Marked elevations of serum CPK were found in the patient and several family members.	Halothane	51-60	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	112-115
943990-5	1976	However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP2 and ejection fraction.	Halothane	9-18	prolyl endopeptidase	Homo sapiens	128-131
5461279-0	1970	[Effect of fluothane anesthesia and surgical stress on the blood HGH and insulin concentration].	Halothane	11-20	insulin	Homo sapiens	73-80
4311926-0	1969	[Plasma levels of ACTH and cortisol in man during halothane anesthesia and surgery].	Halothane	50-59	proopiomelanocortin	Homo sapiens	18-22
5512950-0	1970	[Experience in the use of the NAPP-1 apparatus for fluothane anesthesia in minor gynecologic surgery].	Halothane	51-60	itchy E3 ubiquitin protein ligase	Homo sapiens	30-36
5774514-0	1969	Evaluation of a new halothane vaporizer: the Cyprane Fluotec Mark 3.	Halothane	20-29	microtubule affinity regulating kinase 3	Homo sapiens	61-67
5703706-0	1968	The influence of halothane and diethyl ether on gamma-glutamyl transpeptidase activity in the liver in rats.	Halothane	17-26	gamma-glutamyltransferase 1	Rattus norvegicus	48-77
5370183-0	1969	Histochemical and biochemical studies on the activity of gamma-glutamyl transpeptidase in the central nervous system of rats anesthetized with halothane and diethyl ether.	Halothane	143-152	gamma-glutamyltransferase 1	Rattus norvegicus	57-86
13988292-0	1962	[Modifications of the plasma cholinesterase level in ether and fluothane anesthesia].	Halothane	63-72	butyrylcholinesterase	Homo sapiens	29-43
5994594-0	1966	[On the effect of fluothane anesthesia on serum cholinesterase activity in orthopedic surgery in children].	Halothane	18-27	butyrylcholinesterase	Homo sapiens	48-62
5854905-0	1965	The use of fluothane in ski-accident centres in the Aosta valley, Italy.	Halothane	11-20	SKI proto-oncogene	Homo sapiens	24-27
33301562-2	2021	This study tested the hypothesis that genetically suppressing the function of TRPC6 can partially ameliorate muscle cation dyshomeostasis and the response to halothane in a mouse model relevant to malignant hyperthermia.	Halothane	158-167	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	78-83
33301562-8	2021	Although expression of the muscle-specific dominant-negative TRPC6 was able to modulate the increase in intracellular calcium during halothane exposure and prolonged life (35 +- 5 min vs. 15 +- 3 min; P < 0.0001), a slow, steady increase in calcium began after 20 min of halothane exposure, which eventually led to death.	Halothane	133-142	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	61-66
33301562-8	2021	Although expression of the muscle-specific dominant-negative TRPC6 was able to modulate the increase in intracellular calcium during halothane exposure and prolonged life (35 +- 5 min vs. 15 +- 3 min; P < 0.0001), a slow, steady increase in calcium began after 20 min of halothane exposure, which eventually led to death.	Halothane	271-280	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	61-66
32764093-9	2020	CAF +- HAL are studied on RYR1 single-channel currents and HET myotubes to define molecular mechanisms of gene-by-environment synergism.	Halothane	7-10	caffeine susceptibility	Mus musculus	0-3
32764093-9	2020	CAF +- HAL are studied on RYR1 single-channel currents and HET myotubes to define molecular mechanisms of gene-by-environment synergism.	Halothane	7-10	ryanodine receptor 1, skeletal muscle	Mus musculus	26-30
32764093-11	2020	Central and peripheral nervous systems mediate adverse responses to HAL in a HET model of MH susceptibility exposed to dietary CAF, a modifiable lifestyle factor that may mitigate risks of acute and chronic diseases associated with RYR1 mutations.	Halothane	68-71	caffeine susceptibility	Mus musculus	127-130
32764093-11	2020	Central and peripheral nervous systems mediate adverse responses to HAL in a HET model of MH susceptibility exposed to dietary CAF, a modifiable lifestyle factor that may mitigate risks of acute and chronic diseases associated with RYR1 mutations.	Halothane	68-71	ryanodine receptor 1, skeletal muscle	Mus musculus	232-236
32795494-0	2020	Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice.	Halothane	71-80	ryanodine receptor 1, skeletal muscle	Mus musculus	48-67
32879799-4	2020	CYP2E1, a member of CYP superfamily, affects the metabolism of several clinically important drugs such as halothane, paracetamol, etc.	Halothane	106-115	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
30063925-5	2018	Halothane-induced decreased sarco(endo)plasmic reticulum Ca2+ (SERCA2a) reuptake pump, transient outward K+ (Ito), Na+-Ca2+ exchanger (INCX) and L-type Ca2+ channel (ICaL) currents, together with ryanodine receptor (RyR2) increased open probability (Po) and reduced myofilament Ca2+ sensitivity, reproduced equivalent decreased action potential duration at 90% repolarization and intracellular Ca2+ concentration at the myocyte level reported in the literature.	Halothane	0-9	solute carrier family 8 member A1	Homo sapiens	115-133
32665491-7	2020	Furthermore, local pretreatment with SAR7334 partially decreased the elevation of intracellular resting calcium that is seen in RYR1-p.G2435R muscles during exposure to halothane.	Halothane	169-178	ryanodine receptor 1, skeletal muscle	Mus musculus	128-132
32498517-0	2020	UV-Photodissociation of Halothane in a Focused Molecular Beam: Space-Speed Slice-Imaging of Competitive Bond Breaking into Spin-Orbit Selected Chlorine and Bromine Atoms.	Halothane	24-33	spindlin 1	Homo sapiens	123-127
31987857-6	2020	RESULTS: All the investigated VAs (chloroform, halothane, isoflurane, sevoflurane) inhibited both the agonist-induced (pregnenolone sulfate, CIM0216) and heat-activated Ca2+ signals and transmembrane currents in a concentration dependent way in HEK293T cells overexpressing recombinant TRPM3.	Halothane	47-56	transient receptor potential cation channel subfamily M member 3	Homo sapiens	286-291
31545984-5	2019	Other volatile anesthetics, including isoflurane, enflurane, and halothane, induced IL-6 mRNA in fetal brains as well as sevoflurane, but propofol did not.	Halothane	65-74	interleukin 6	Mus musculus	84-88
30707122-2	2019	WHAT THIS ARTICLE TELLS US THAT IS NEW: In a tamoxifen-activated astrocyte-specific Ndufs4(KO) mouse, the induction EC50s for tail clamp in both isoflurane and halothane were similar between the control and astrocyte-specific Ndufs4(KO) mice at 3 weeks after 4-hydroxy tamoxifen injection.	Halothane	160-169	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	84-90
30063925-5	2018	Halothane-induced decreased sarco(endo)plasmic reticulum Ca2+ (SERCA2a) reuptake pump, transient outward K+ (Ito), Na+-Ca2+ exchanger (INCX) and L-type Ca2+ channel (ICaL) currents, together with ryanodine receptor (RyR2) increased open probability (Po) and reduced myofilament Ca2+ sensitivity, reproduced equivalent decreased action potential duration at 90% repolarization and intracellular Ca2+ concentration at the myocyte level reported in the literature.	Halothane	0-9	ryanodine receptor 2	Homo sapiens	216-220
29274133-10	2018	Adenosine-induced hyperpolarization was mediated by background K+ currents that were reduced by halothane and bupivacaine, which are known to inhibit two-pore domain K+ (K2P) channels.	Halothane	96-105	keratin 76	Homo sapiens	170-173
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	96-105	interleukin 10	Rattus norvegicus	40-45
29247050-0	2018	Voltage modulates halothane-triggered Ca2+ release in malignant hyperthermia-susceptible muscle.	Halothane	18-27	carbonic anhydrase 2	Mus musculus	38-41
29247050-13	2018	We conclude that the binding of halothane to RyR1 alters the voltage dependence of Ca2+ release in MH-susceptible muscle fibers such that the resting membrane potential becomes a decisive factor for the efficiency of the drug to trigger Ca2+ release.	Halothane	32-41	ryanodine receptor 1, skeletal muscle	Mus musculus	45-49
29247050-13	2018	We conclude that the binding of halothane to RyR1 alters the voltage dependence of Ca2+ release in MH-susceptible muscle fibers such that the resting membrane potential becomes a decisive factor for the efficiency of the drug to trigger Ca2+ release.	Halothane	32-41	carbonic anhydrase 2	Mus musculus	83-86
29247050-13	2018	We conclude that the binding of halothane to RyR1 alters the voltage dependence of Ca2+ release in MH-susceptible muscle fibers such that the resting membrane potential becomes a decisive factor for the efficiency of the drug to trigger Ca2+ release.	Halothane	32-41	carbonic anhydrase 2	Mus musculus	237-240
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	96-105	interleukin 4	Rattus norvegicus	50-54
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	96-105	interleukin 1 beta	Rattus norvegicus	182-190
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 10	Rattus norvegicus	40-45
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 4	Rattus norvegicus	50-54
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 1 beta	Rattus norvegicus	182-190
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 10	Rattus norvegicus	40-45
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 4	Rattus norvegicus	50-54
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 1 beta	Rattus norvegicus	182-190
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 10	Rattus norvegicus	40-45
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 4	Rattus norvegicus	50-54
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Halothane	124-133	interleukin 1 beta	Rattus norvegicus	182-190
28081667-8	2018	Halothane increased AST/ALT levels, caspase-3 and -8 activities (but not malondialdehyde) concomitant with widespread hepatotoxicity.	Halothane	0-9	solute carrier family 17 member 5	Homo sapiens	20-23
28081667-10	2018	In co-culture, halothane increased caspase-8 activity and decreased MMP and cellular viability.	Halothane	15-24	caspase 8	Homo sapiens	35-44
28609560-7	2017	Halothane anaesthesia increased BDNF and TrkB mRNA bilaterally.	Halothane	0-9	brain-derived neurotrophic factor	Rattus norvegicus	32-36
28609560-7	2017	Halothane anaesthesia increased BDNF and TrkB mRNA bilaterally.	Halothane	0-9	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	41-45
28609560-9	2017	Further, halothane anaesthesia, surgical procedures, and nerve injury each decreased BDNF protein levels.	Halothane	9-18	brain-derived neurotrophic factor	Rattus norvegicus	85-89
30873473-8	2017	This hypothesis has shown promise in developing valid animal models of IDILI as demonstrated by a halothane induced liver injury mouse model developed by depleting myeloid derived suppressor cells (MDSCs), as well as an amodiaquine-, isoniazid-and nevirapine-induced liver injury mouse model developed by impairing immune tolerance by blocking PD-1 and CTLA-4, two immune checkpoint inhibitors.	Halothane	98-107	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	353-359
29016681-12	2017	The sensitivities of TASK1-TALK2 tandem constructs to extracellular pH and halothane were characterized as a unique hybrid of TASK1 and TALK2.	Halothane	75-84	potassium two pore domain channel subfamily K member 17	Homo sapiens	27-32
29016681-12	2017	The sensitivities of TASK1-TALK2 tandem constructs to extracellular pH and halothane were characterized as a unique hybrid of TASK1 and TALK2.	Halothane	75-84	potassium two pore domain channel subfamily K member 17	Homo sapiens	136-141
27854153-3	2017	Recessive Hal pigs (Halnn) have defective Ca2+ release channels (CRC) or Ryanodine Receptors (RYR1) within the sarcoplasmic reticulum that allow uncontrolled release of Ca2+ in response to stress.	Halothane	10-13	ryanodine receptor 1	Sus scrofa	94-98
28676376-1	2017	Tandem pore-domain Halothane Inhibited K+ channel (THIK1) is a two-pore-domain potassium channel (K2P) present in dorsal root ganglia (DRG).	Halothane	19-28	potassium two pore domain channel subfamily K member 13	Rattus norvegicus	51-56
28079567-8	2017	Halothane potentiated luminal and cytoplasmic Ca activation of ryanodine receptor 2 but had no effect on Mg inhibition.	Halothane	0-9	ryanodine receptor 2	Ovis aries	63-83
28079567-9	2017	Halothane activated ryanodine receptor 2 in the absence and presence (2 mM) of adenosine triphosphate (ATP).	Halothane	0-9	ryanodine receptor 2	Ovis aries	20-40
28079567-11	2017	CONCLUSIONS: At clinical concentrations (1 MAC), halothane desflurane and enflurane activated ryanodine receptor 2, whereas isoflurane and sevoflurane were ineffective.	Halothane	49-58	ryanodine receptor 2	Ovis aries	94-114
28079567-13	2017	Halothane acted independently of the adenine nucleotide-binding site on ryanodine receptor 2.	Halothane	0-9	ryanodine receptor 2	Ovis aries	72-92
29062464-2	2017	Incidence of mortality in male calsequestrin-1 knockout (CASQ1-null) mice during exposure to halothane and heat (a syndrome closely resembling human MH) is far greater than that in females.	Halothane	93-102	calsequestrin 1	Mus musculus	31-46
29062464-2	2017	Incidence of mortality in male calsequestrin-1 knockout (CASQ1-null) mice during exposure to halothane and heat (a syndrome closely resembling human MH) is far greater than that in females.	Halothane	93-102	calsequestrin 1	Mus musculus	57-62
25712247-4	2015	Twenty-four hours after female Balb/cJ mice were initially treated with halothane, perivenous necrosis and an infiltration of CD11b(+) Gr-1(high) cells were observed in the liver.	Halothane	72-81	integrin subunit alpha M	Homo sapiens	126-131
26120770-4	2015	The authors demonstrate that halothane mitigates the risk of SBP postflu through modulation of the effects of type I interferon (IFN).	Halothane	29-38	spermine binding protein	Mus musculus	61-64
26132720-0	2015	Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death.	Halothane	56-65	calsequestrin 1	Mus musculus	21-36
26132720-1	2015	BACKGROUND: Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress.	Halothane	244-253	calsequestrin 1	Mus musculus	25-40
26132720-1	2015	BACKGROUND: Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to halothane or heat stress.	Halothane	244-253	calsequestrin 1	Mus musculus	42-47
25712247-6	2015	When CD11b(+) Gr-1(high) cells were depleted from the liver with Gr-1 antibody treatment, enhanced liver injury was observed at 9 days after halothane rechallenge.	Halothane	141-150	integrin subunit alpha M	Homo sapiens	5-10
25712247-8	2015	When hepatic CD4(+) T cells were depleted 5 days after halothane rechallenge, trifluoroacetylated protein adduct-specific serum immunoglobulin and hepatotoxicity were reduced.	Halothane	55-64	CD4 molecule	Homo sapiens	13-16
25424378-7	2015	Interestingly, also ablation of skeletal muscle calsequestrin (CASQ1) leads to a phenotype with MH-like lethal episodes in response to halothane and heat stress and development of central cores.	Halothane	135-144	calsequestrin 1	Mus musculus	63-68
25057841-7	2014	RESULTS: In vivo exposure to isoflurane and halothane doubled the fraction of active, c-Fos-expressing GABAergic neurons in the VLPO, whereas F6 failed to affect VLPO c-Fos expression.	Halothane	44-53	FBJ osteosarcoma oncogene	Mus musculus	86-91
25148687-0	2014	Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.	Halothane	19-28	potassium two pore domain channel subfamily K member 13	Homo sapiens	59-64
24723460-0	2014	Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.	Halothane	75-84	interleukin 4	Mus musculus	33-46
25148687-0	2014	Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.	Halothane	19-28	potassium two pore domain channel subfamily K member 12	Homo sapiens	69-74
25148687-1	2014	Despite a high level of sequence homology, tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents, whereas THIK2 is silent.	Halothane	62-71	potassium two pore domain channel subfamily K member 13	Homo sapiens	98-103
25593732-8	2014	Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic.	Halothane	0-9	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	104-124
25593732-8	2014	Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic.	Halothane	0-9	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	126-132
24081450-3	2014	As reported earlier, whole-cell THIK-1 current was inhibited by halothane and activated by arachidonic acid.	Halothane	64-73	potassium two pore domain channel subfamily K member 13	Homo sapiens	32-38
24081450-6	2014	Halothane, bupivacaine and cold inhibited the single-channel activities of both THIK-1 and the 5-pS channel in TG neurons, whereas arachidonic acid augmented them.	Halothane	0-9	potassium two pore domain channel subfamily K member 13	Homo sapiens	80-86
24081560-7	2014	SKF 89976A, a GABA transporter type 1 (GAT-1) inhibitor, reduced the sevoflurane- and halothane-induced increase in the accumulation of GABA by 57 and 63 %, respectively.	Halothane	86-95	solute carrier family 6 member 12	Rattus norvegicus	14-44
24598351-11	2014	Subsequently target of miR-106b was investigated using liver samples from mice with HAL-induced liver injury.	Halothane	84-87	microRNA 106b	Mus musculus	23-31
24598351-12	2014	Among the predicted targets, we discovered that a signal transducer and activator of transcription 3 (STAT3) was particularly up-regulated beginning during the early phase of HAL-induced liver injury.	Halothane	175-178	signal transducer and activator of transcription 3	Mus musculus	50-100
24598351-12	2014	Among the predicted targets, we discovered that a signal transducer and activator of transcription 3 (STAT3) was particularly up-regulated beginning during the early phase of HAL-induced liver injury.	Halothane	175-178	signal transducer and activator of transcription 3	Mus musculus	102-107
24598351-13	2014	Collectively, the suppressed miR-106b expression, as well as the subsequent up-regulation of STAT3, was critical for the pathogenesis of HAL-induced liver injury.	Halothane	137-140	microRNA 106b	Mus musculus	29-37
24598351-13	2014	Collectively, the suppressed miR-106b expression, as well as the subsequent up-regulation of STAT3, was critical for the pathogenesis of HAL-induced liver injury.	Halothane	137-140	signal transducer and activator of transcription 3	Mus musculus	93-98
24535863-2	2014	Previous studies have suggested that IMF deposition may be associated with the presence of the halothane (HAL) gene.	Halothane	95-104	IMF	Sus scrofa	37-40
24535863-2	2014	Previous studies have suggested that IMF deposition may be associated with the presence of the halothane (HAL) gene.	Halothane	95-104	ryanodine receptor 1	Sus scrofa	106-109
23558838-10	2013	Maximal contractures in the caffeine-halothane contracture test were greater in those who had a known MH mutation or variant of uncertain significance in RYR1 than in those who did not.	Halothane	37-46	ryanodine receptor 1	Homo sapiens	154-158
23876740-7	2013	Airway hyperresponsiveness, BAL eosinophilia, peripheral lung inflammation, IL-5 mRNA production and collagen deposition were significantly increased in halothane OA-challenged compared to isoflurane OA-challenged mice.	Halothane	153-162	interleukin 5	Mus musculus	76-80
24163367-0	2013	Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.	Halothane	36-45	potassium two pore domain channel subfamily K member 12	Homo sapiens	70-75
24163367-1	2013	The tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents.	Halothane	23-32	potassium two pore domain channel subfamily K member 13	Homo sapiens	59-64
24163367-4	2013	A THIK2 mutant containing a proline residue (THIK2-A155P) in its second inner helix (M2) produces K(+)-selective currents with properties similar to THIK1, including inhibition by halothane and insensitivity to extracellular pH variations.	Halothane	180-189	potassium two pore domain channel subfamily K member 12	Homo sapiens	2-7
24163367-4	2013	A THIK2 mutant containing a proline residue (THIK2-A155P) in its second inner helix (M2) produces K(+)-selective currents with properties similar to THIK1, including inhibition by halothane and insensitivity to extracellular pH variations.	Halothane	180-189	potassium two pore domain channel subfamily K member 12	Homo sapiens	45-50
23844269-0	2013	Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax.	Halothane	0-9	microRNA 214	Rattus norvegicus	72-79
23844269-0	2013	Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax.	Halothane	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	97-100
23844269-4	2013	We found that halothane could enhance the cytotoxicity induced by intracellular or extracellular amyloid beta (Abeta) with or without serum deprivation.	Halothane	14-23	amyloid beta precursor protein	Rattus norvegicus	111-116
23844269-5	2013	In addition, halothane induced the enhanced cytotoxicity through downregulation of miR-214 level which can lead to increasing expression of Bax.	Halothane	13-22	microRNA 214	Rattus norvegicus	83-90
23844269-5	2013	In addition, halothane induced the enhanced cytotoxicity through downregulation of miR-214 level which can lead to increasing expression of Bax.	Halothane	13-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	140-143
23844269-6	2013	Therefore our data suggest that halothane increases cell death induced by Abeta through increasing Bax level by downregulating miR-214.	Halothane	32-41	amyloid beta precursor protein	Rattus norvegicus	74-79
23844269-6	2013	Therefore our data suggest that halothane increases cell death induced by Abeta through increasing Bax level by downregulating miR-214.	Halothane	32-41	BCL2 associated X, apoptosis regulator	Rattus norvegicus	99-102
23844269-6	2013	Therefore our data suggest that halothane increases cell death induced by Abeta through increasing Bax level by downregulating miR-214.	Halothane	32-41	microRNA 214	Rattus norvegicus	127-134
22836013-9	2012	At excitatory synapses on to CA3 neurons, halothane has no presynaptic action-effecting only extrasynaptic receptors.	Halothane	42-51	carbonic anhydrase 3	Rattus norvegicus	29-32
23238640-6	2013	Chemokines, eotaxin-1 (CCL11) and eotaxin-2 (CCL24), which are known to attract eosinophils, increased in response to halothane treatment.	Halothane	118-127	chemokine (C-C motif) ligand 11	Mus musculus	23-28
23238640-6	2013	Chemokines, eotaxin-1 (CCL11) and eotaxin-2 (CCL24), which are known to attract eosinophils, increased in response to halothane treatment.	Halothane	118-127	chemokine (C-C motif) ligand 24	Mus musculus	34-43
23238640-6	2013	Chemokines, eotaxin-1 (CCL11) and eotaxin-2 (CCL24), which are known to attract eosinophils, increased in response to halothane treatment.	Halothane	118-127	chemokine (C-C motif) ligand 24	Mus musculus	45-50
23159934-5	2013	[Ca(2+)]i and [Na(+)]i are persistently elevated in vivo and further increased by halothane in MH-RyR1(R163C/WT) muscle.	Halothane	82-91	ryanodine receptor 1, skeletal muscle	Mus musculus	98-102
23103189-4	2012	RESULTS: Using c-Fos immunohistochemistry as a biomarker for antecedent neuronal activity, we show that isoflurane and halothane increase the number of active neurons in the VLPO, but only when mice are sedated or unconscious.	Halothane	119-128	FBJ osteosarcoma oncogene	Mus musculus	15-20
23042227-6	2012	However, the most profound effect of adrenergic deficiency is retarding emergence from anesthesia, which takes two to three times as long in Dbh mice for sevoflurane, isoflurane, and halothane.	Halothane	183-192	dopamine beta hydroxylase	Mus musculus	141-144
23254148-2	2013	The mammalian ryanodine receptor (Ryr) is a known halothane target, and the authors hypothesized that it has a central role in anesthesia.	Halothane	50-59	ryanodine receptor 2	Homo sapiens	14-32
23254148-2	2013	The mammalian ryanodine receptor (Ryr) is a known halothane target, and the authors hypothesized that it has a central role in anesthesia.	Halothane	50-59	ryanodine receptor 2	Homo sapiens	34-37
23254148-3	2013	METHODS: Gene function of the Drosophila Ryr (dRyr) was manipulated in the whole body or in specific tissues using a collection of mutants and transgenes, and responses to halothane were measured with a reactive climbing assay.	Halothane	172-181	Ryanodine receptor	Drosophila melanogaster	41-44
23254148-3	2013	METHODS: Gene function of the Drosophila Ryr (dRyr) was manipulated in the whole body or in specific tissues using a collection of mutants and transgenes, and responses to halothane were measured with a reactive climbing assay.	Halothane	172-181	Ryanodine receptor	Drosophila melanogaster	46-50
23254148-5	2013	RESULTS: Halothane potency strongly correlates with dRyr gene copy number, and missense mutations in regions known to be functionally important in the mammalian Ryrs gene cause dominant hypersensitivity.	Halothane	9-18	Ryanodine receptor	Drosophila melanogaster	52-56
23254148-6	2013	Tissue-specific manipulation of dRyr shows that expression in neurons and glia, but not muscle, mediates halothane sensitivity.	Halothane	105-114	Ryanodine receptor	Drosophila melanogaster	32-36
23254148-7	2013	In cultured cells, halothane-induced Ca efflux is strictly dRyr-dependent, suggesting a close interaction between halothane and dRyr.	Halothane	19-28	Ryanodine receptor	Drosophila melanogaster	59-63
23254148-7	2013	In cultured cells, halothane-induced Ca efflux is strictly dRyr-dependent, suggesting a close interaction between halothane and dRyr.	Halothane	19-28	Ryanodine receptor	Drosophila melanogaster	128-132
23254148-7	2013	In cultured cells, halothane-induced Ca efflux is strictly dRyr-dependent, suggesting a close interaction between halothane and dRyr.	Halothane	114-123	Ryanodine receptor	Drosophila melanogaster	59-63
23254148-8	2013	Ca imaging and electrophysiology of Drosophila central neurons reveal halothane-induced Ca flux that is altered in dRyr mutants and correlates with strong hyperpolarization.	Halothane	70-79	Ryanodine receptor	Drosophila melanogaster	115-119
23254148-9	2013	CONCLUSIONS: In Drosophila, neurally expressed dRyr mediates a substantial proportion of the anesthetic effects of halothane in vivo, is potently activated by halothane in vitro, and activates an inhibitory conductance.	Halothane	115-124	Ryanodine receptor	Drosophila melanogaster	47-51
23254148-9	2013	CONCLUSIONS: In Drosophila, neurally expressed dRyr mediates a substantial proportion of the anesthetic effects of halothane in vivo, is potently activated by halothane in vitro, and activates an inhibitory conductance.	Halothane	159-168	Ryanodine receptor	Drosophila melanogaster	47-51
23460944-4	2013	METHODS: The entire coding region of CASQ1 in 75 unrelated patients diagnosed by caffeine-halothane contracture test as MH susceptible (MHS) was analyzed by DNA sequencing.	Halothane	90-99	calsequestrin 1	Homo sapiens	37-42
23000369-7	2013	Halothane, but not ketamine, was also found in cavities adjacent to the common anesthetic site at the interface of alpha4 and beta2.	Halothane	0-9	immunoglobulin binding protein 1	Homo sapiens	115-121
23000369-7	2013	Halothane, but not ketamine, was also found in cavities adjacent to the common anesthetic site at the interface of alpha4 and beta2.	Halothane	0-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	126-131
22497566-1	2013	The mouse hepatic cytochrome P450 (CYP) 2A5 and its human orthologue CYP2A6 catalyse the metabolism of a number of drugs and toxins, such as halothane and aflatoxin B1.	Halothane	141-150	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	18-43
22497566-1	2013	The mouse hepatic cytochrome P450 (CYP) 2A5 and its human orthologue CYP2A6 catalyse the metabolism of a number of drugs and toxins, such as halothane and aflatoxin B1.	Halothane	141-150	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	69-75
22836013-8	2012	These results suggest that halothane acts predominantly at presynaptic sites at GABAergic synapses to enhance inhibitory transmission at CA3 synapses, although it also increases extra-synaptic GABA responses.	Halothane	27-36	carbonic anhydrase 3	Rattus norvegicus	137-140
22157104-9	2012	Progesterone pretreatment increased the extracellular signal-regulated kinase (ERK) phosphorylation in HAL-induced liver injury.	Halothane	103-106	mitogen-activated protein kinase 1	Mus musculus	40-77
23031527-1	2012	Previous reports have indicated that a proportion of pigs, homozygous normal for the skeletal muscle ryanodine receptor gene (RYR1), was halothane sensitive, and this was associated with poor meat quality when pigs were handled aggressively.	Halothane	137-146	ryanodine receptor 1	Sus scrofa	85-119
23031527-1	2012	Previous reports have indicated that a proportion of pigs, homozygous normal for the skeletal muscle ryanodine receptor gene (RYR1), was halothane sensitive, and this was associated with poor meat quality when pigs were handled aggressively.	Halothane	137-146	ryanodine receptor 1	Sus scrofa	126-130
21945072-6	2012	Mutants of the slo-1, rab-3 and unc-64 genes that are resistant to ethanol or the volatile anesthetic halothane show no resistance to toluene.	Halothane	102-111	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	15-20
21945072-6	2012	Mutants of the slo-1, rab-3 and unc-64 genes that are resistant to ethanol or the volatile anesthetic halothane show no resistance to toluene.	Halothane	102-111	Ras-related protein Rab-3	Caenorhabditis elegans	22-27
21945072-6	2012	Mutants of the slo-1, rab-3 and unc-64 genes that are resistant to ethanol or the volatile anesthetic halothane show no resistance to toluene.	Halothane	102-111	Syntaxin-1A homolog	Caenorhabditis elegans	32-38
21945072-7	2012	A mutation in the unc-79 gene results in hypersensitivity to ethanol, halothane and toluene indicating a possible convergence of mechanisms of the three compounds.	Halothane	70-79	Uncoordinated protein 79	Caenorhabditis elegans	18-24
22394379-8	2012	These results establish the presence of two distinct bupropion binding sites within the Torpedo nAChR transmembrane domain: a high affinity site at the middle (M2-9) of the ion channel and a second site near the extracellular end of alphaM1 within a previously described halothane (general anesthetic) binding pocket.	Halothane	271-280	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	96-101
22157104-9	2012	Progesterone pretreatment increased the extracellular signal-regulated kinase (ERK) phosphorylation in HAL-induced liver injury.	Halothane	103-106	mitogen-activated protein kinase 1	Mus musculus	79-82
22025496-9	2012	The calorimetric heat profiles of propofol and halothane interaction with HSA were changed significantly, but not equally by morphine, naloxone, or fentanyl.	Halothane	47-56	albumin	Homo sapiens	74-77
22130610-9	2011	Consistent with this idea, CASQ1-null mice exhibit an increased susceptibility to undergo a hypermetabolic syndrome characterized by whole body contractures, rhabdomyolysis, hyperthermia and sudden death in response to halothane- and heat-exposure, a phenotype remarkably similar to human malignant hyperthermia and environmental heat-stroke.	Halothane	219-228	calsequestrin 1	Mus musculus	27-32
21617274-11	2011	The results of conducted by us studies revealed, that during the application of halothane narcosis causes an increase in the GABA positive cells in the fields CA1 on hippocampus of adult white rats.	Halothane	80-89	carbonic anhydrase 1	Rattus norvegicus	159-162
21617274-12	2011	In 24 hours after sham operation, at the condition of application of halothane narcosis a quantity of GABA positive cells raises in the CA3 field of hippocampus in II group animals as well.	Halothane	69-78	carbonic anhydrase 3	Rattus norvegicus	136-139
20610767-6	2010	Single-cell reverse transcription-PCR analysis of dissociated green fluorescent protein-labeled RTN neurons revealed expression of THIK-1 (TWIK-related halothane-inhibited K(+) channel, K(2P)13.1), a channel that shares key properties with the native RTN current (i.e., suppression by inhalational anesthetics, weak rectification, inhibition by extracellular Na(+), and pH-insensitivity).	Halothane	152-161	potassium two pore domain channel subfamily K member 13	Rattus norvegicus	131-137
21245496-6	2011	Plasma interferon-gamma (IFN-gamma) was elevated 10-fold in HAL-treated females compared with similarly treated male mice or with OVX female mice.	Halothane	60-63	interferon gamma	Mus musculus	7-23
21245496-6	2011	Plasma interferon-gamma (IFN-gamma) was elevated 10-fold in HAL-treated females compared with similarly treated male mice or with OVX female mice.	Halothane	60-63	interferon gamma	Mus musculus	25-34
21245496-7	2011	IFN-gamma knockout mice were resistant to severe HAL-induced liver injury.	Halothane	49-52	interferon gamma	Mus musculus	0-9
21245496-10	2011	Furthermore, HAL increased the activity of NK cells in vivo, as indicated by increased surface expression of CD69, an early activation marker.	Halothane	13-16	CD69 antigen	Mus musculus	109-113
21245496-12	2011	These results confirm the sexual dimorphic hepatotoxic response to HAL in mice and suggest that IFN-gamma and NK cells have essential roles in the development of severe HAL-induced hepatotoxicity.	Halothane	169-172	interferon gamma	Mus musculus	96-105
20978128-2	2011	Heterozygous mice expressing the human MH/central core disease RyR1 R163C mutation exhibit MH when exposed to halothane or heat stress.	Halothane	110-119	ryanodine receptor 1	Homo sapiens	63-67
20661501-5	2010	At the majority of binding sites in alpha4beta2 nAChR, halothane replaced the slow-exchanging water molecules and caused a regional water population decrease.	Halothane	55-64	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	48-53
20359463-8	2010	Compared with WT mice, CD1d(-/-) mice exhibited a significantly lower number of hepatic infiltrating neutrophils upon halothane challenge (470,000+/-100,000/liver in WT vs. 120,000+/-31,500/liver in CD1d(-/-) mice).	Halothane	118-127	CD1d1 antigen	Mus musculus	23-27
21290074-1	2011	The structures and intermolecular interactions in the halogen bonded complexes of anaesthetics (chloroform, halothane, enflurane and isoflurane) with formaldehyde were studied by ab initio MP2 and CCSD(T) methods.	Halothane	108-117	tryptase pseudogene 1	Homo sapiens	189-192
21290074-3	2011	The largest stabilization energy has been found for the C-Br   O bonded halothane   OCH(2) complex.	Halothane	72-81	cannabinoid receptor 1	Homo sapiens	56-60
21823098-0	2011	Influence of the halothane gene (HAL) on pork quality in two commercial crossbreeds.	Halothane	17-26	ryanodine receptor 1	Sus scrofa	33-36
21823098-1	2011	We evaluated the effect of the halothane (HAL) gene on the quality of pork in domestic pigs.	Halothane	31-40	ryanodine receptor 1	Sus scrofa	42-45
20610767-6	2010	Single-cell reverse transcription-PCR analysis of dissociated green fluorescent protein-labeled RTN neurons revealed expression of THIK-1 (TWIK-related halothane-inhibited K(+) channel, K(2P)13.1), a channel that shares key properties with the native RTN current (i.e., suppression by inhalational anesthetics, weak rectification, inhibition by extracellular Na(+), and pH-insensitivity).	Halothane	152-161	potassium two pore domain channel subfamily K member 1	Rattus norvegicus	139-143
20460989-4	2010	RESULTS: Both PSD-95/SAP90 and PSD-93/Chapsyn-110 antisense oligodeoxynucleotides caused a dose-dependent and significant reduction in the MAC of halothane in wild-type mice.	Halothane	146-155	discs large MAGUK scaffold protein 4	Mus musculus	14-20
20465243-14	2010	In contrast, correlated motion of the open-channel alpha4beta2 was reduced substantially in the presence of halothane, primarily due to the more susceptible nature of beta2 to anesthetic modulation.	Halothane	108-117	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-62
20465243-15	2010	The amphiphilic extracellular and transmembrane domain interface of the beta2 subunit is attractive to halothane and is susceptible to halothane perturbation, which may be why alpha4beta2 is functionally more sensitive to halothane than alpha7.	Halothane	103-112	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
20465243-15	2010	The amphiphilic extracellular and transmembrane domain interface of the beta2 subunit is attractive to halothane and is susceptible to halothane perturbation, which may be why alpha4beta2 is functionally more sensitive to halothane than alpha7.	Halothane	135-144	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
20465243-15	2010	The amphiphilic extracellular and transmembrane domain interface of the beta2 subunit is attractive to halothane and is susceptible to halothane perturbation, which may be why alpha4beta2 is functionally more sensitive to halothane than alpha7.	Halothane	135-144	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
20460989-5	2010	The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide at different doses (25 and 50 microg) reduced halothane MAC by 40 and 55%, respectively, and intrathecal injection of PSD-93/Chapsyn-110 antisense oligodeoxynucleotide at different doses (12 and 24 microg) reduced halothane MAC by 25 and 53%, respectively.	Halothane	287-296	discs large MAGUK scaffold protein 4	Mus musculus	29-35
20460989-5	2010	The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide at different doses (25 and 50 microg) reduced halothane MAC by 40 and 55%, respectively, and intrathecal injection of PSD-93/Chapsyn-110 antisense oligodeoxynucleotide at different doses (12 and 24 microg) reduced halothane MAC by 25 and 53%, respectively.	Halothane	287-296	discs large MAGUK scaffold protein 4	Mus musculus	36-41
20460989-4	2010	RESULTS: Both PSD-95/SAP90 and PSD-93/Chapsyn-110 antisense oligodeoxynucleotides caused a dose-dependent and significant reduction in the MAC of halothane in wild-type mice.	Halothane	146-155	discs large MAGUK scaffold protein 4	Mus musculus	21-26
20460989-6	2010	The PSD-95/SAP90 antisense oligodeoxynucleotide showed similar effect on halothane MAC in wild-type and PSD-93/Chapsyn-110 knockout mice, suggesting that the combination of PSD-95/SAP90 knockdown with PSD-93/Chapsyn-110 deletion did not have an additive effect on halothane anesthesia.	Halothane	73-82	discs large MAGUK scaffold protein 4	Mus musculus	4-10
20460989-4	2010	RESULTS: Both PSD-95/SAP90 and PSD-93/Chapsyn-110 antisense oligodeoxynucleotides caused a dose-dependent and significant reduction in the MAC of halothane in wild-type mice.	Halothane	146-155	discs large MAGUK scaffold protein 2	Mus musculus	31-37
20460989-6	2010	The PSD-95/SAP90 antisense oligodeoxynucleotide showed similar effect on halothane MAC in wild-type and PSD-93/Chapsyn-110 knockout mice, suggesting that the combination of PSD-95/SAP90 knockdown with PSD-93/Chapsyn-110 deletion did not have an additive effect on halothane anesthesia.	Halothane	73-82	discs large MAGUK scaffold protein 4	Mus musculus	11-16
20460989-6	2010	The PSD-95/SAP90 antisense oligodeoxynucleotide showed similar effect on halothane MAC in wild-type and PSD-93/Chapsyn-110 knockout mice, suggesting that the combination of PSD-95/SAP90 knockdown with PSD-93/Chapsyn-110 deletion did not have an additive effect on halothane anesthesia.	Halothane	264-273	discs large MAGUK scaffold protein 4	Mus musculus	4-10
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 4	Mus musculus	47-53
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 4	Mus musculus	54-59
20460989-4	2010	RESULTS: Both PSD-95/SAP90 and PSD-93/Chapsyn-110 antisense oligodeoxynucleotides caused a dose-dependent and significant reduction in the MAC of halothane in wild-type mice.	Halothane	146-155	discs large MAGUK scaffold protein 2	Mus musculus	38-49
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 2	Mus musculus	64-70
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 2	Mus musculus	71-82
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 4	Mus musculus	180-186
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 4	Mus musculus	187-192
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 2	Mus musculus	239-245
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	127-136	discs large MAGUK scaffold protein 2	Mus musculus	246-257
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 4	Mus musculus	47-53
20460989-5	2010	The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide at different doses (25 and 50 microg) reduced halothane MAC by 40 and 55%, respectively, and intrathecal injection of PSD-93/Chapsyn-110 antisense oligodeoxynucleotide at different doses (12 and 24 microg) reduced halothane MAC by 25 and 53%, respectively.	Halothane	119-128	discs large MAGUK scaffold protein 4	Mus musculus	29-35
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 2	Mus musculus	64-70
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 4	Mus musculus	180-186
20460989-5	2010	The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide at different doses (25 and 50 microg) reduced halothane MAC by 40 and 55%, respectively, and intrathecal injection of PSD-93/Chapsyn-110 antisense oligodeoxynucleotide at different doses (12 and 24 microg) reduced halothane MAC by 25 and 53%, respectively.	Halothane	119-128	discs large MAGUK scaffold protein 4	Mus musculus	36-41
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 4	Mus musculus	187-192
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 2	Mus musculus	239-245
20460989-5	2010	The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide at different doses (25 and 50 microg) reduced halothane MAC by 40 and 55%, respectively, and intrathecal injection of PSD-93/Chapsyn-110 antisense oligodeoxynucleotide at different doses (12 and 24 microg) reduced halothane MAC by 25 and 53%, respectively.	Halothane	119-128	discs large MAGUK scaffold protein 2	Mus musculus	191-197
20460989-7	2010	CONCLUSIONS: The current results indicate that PSD-95/SAP90 and PSD-93/Chapsyn-110 are involved in the molecular mechanisms of halothane anesthesia and that the functional role of PSD-95/SAP90 in halothane anesthesia is not enhanced after PSD-93/Chapsyn-110 deletion.	Halothane	196-205	discs large MAGUK scaffold protein 2	Mus musculus	246-257
20164598-3	2010	In this present experimental study, using state-of-the-art nuclear magnetic resonance, we have monitored the influence of a larger sized intravenous anesthetic, diazepam, as well as diazepam co-administered with halothane, on Abeta.	Halothane	212-221	amyloid beta precursor protein	Homo sapiens	226-231
20124411-7	2010	In halothane-treated females, plasma concentration of tumor necrosis factor-alpha was greater than in males, and neutrophils were recruited to liver more rapidly and to a greater extent.	Halothane	3-12	tumor necrosis factor	Mus musculus	54-81
20124411-8	2010	Anti-CD18 serum attenuated halothane-induced liver injury in female mice, suggesting that neutrophil migration, activation, or both are required for injury.	Halothane	27-36	lymphotoxin B receptor	Mus musculus	5-9
19715664-3	2010	The structure, topology, and dynamics of the alpha4 TM2 and (alpha4)(2)(beta2)(3) TM2 in magnetically aligned phospholipid bicelles were investigated using solid-state NMR spectroscopy in the absence and presence of halothane and isoflurane, two clinically used volatile anesthetics.	Halothane	216-225	immunoglobulin binding protein 1	Homo sapiens	45-51
20014754-0	2010	Higher susceptibility to halothane modulation in open- than in closed-channel alpha4beta2 nAChR revealed by molecular dynamics simulations.	Halothane	25-34	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	90-95
20014754-10	2010	Comparison of the nonbonded interactions at the EC/TM interfaces suggested that the beta2 subunits were more prone than the alpha4 subunits to halothane binding.	Halothane	143-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	84-89
20014754-10	2010	Comparison of the nonbonded interactions at the EC/TM interfaces suggested that the beta2 subunits were more prone than the alpha4 subunits to halothane binding.	Halothane	143-152	immunoglobulin binding protein 1	Homo sapiens	124-130
20014754-12	2010	The study concludes that sensitivity and global dynamics responsiveness of alpha4beta2 nAChR to halothane are conformation dependent.	Halothane	96-105	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	87-92
20164598-5	2010	However, when diazepam was co-administered with halothane, profound Abeta oligomerization is observed.	Halothane	48-57	amyloid beta precursor protein	Homo sapiens	68-73
20023768-7	2009	The MH-triggering volatile anesthetic, halothane, activates RyR1(R615C) and RyR1(WT) to a similar extent, using [(3)H]ryanodine binding as a measure of activation.	Halothane	39-48	ryanodine receptor 1	Homo sapiens	60-64
19716373-7	2010	A substantially impaired recovery rate was also observed in hclB(T1) after anaesthesia with halothane.	Halothane	92-101	Histamine-gated chloride channel subunit 1	Drosophila melanogaster	60-64
19809293-11	2009	Microinjection of the orexin-1 receptor antagonist SB-334867-A during the active period slowed firing rates of locus coeruleus neurons in halothane-anesthetized rats, but had no effect on isoflurane-anesthetized rats.	Halothane	138-147	hypocretin	Mus musculus	22-28
19809293-14	2009	Normal emergence from halothane-induced hypnosis in orexin-deficient mice suggests that additional wake-promoting systems likely remain active during general anesthesia produced by halothane.	Halothane	22-31	hypocretin	Mus musculus	52-58
19809293-14	2009	Normal emergence from halothane-induced hypnosis in orexin-deficient mice suggests that additional wake-promoting systems likely remain active during general anesthesia produced by halothane.	Halothane	181-190	hypocretin	Mus musculus	52-58
19633216-7	2009	We observed increases of the plasma IL-17 level and hepatic macrophage inflammatory protein 2 expression in halothane-administrated BALB/c mice, as well as neutrophil infiltration.	Halothane	108-117	interleukin 17A	Mus musculus	36-41
19633216-7	2009	We observed increases of the plasma IL-17 level and hepatic macrophage inflammatory protein 2 expression in halothane-administrated BALB/c mice, as well as neutrophil infiltration.	Halothane	108-117	chemokine (C-X-C motif) ligand 2	Mus musculus	60-93
19633216-8	2009	Neutralization of IL-17 suppressed the hepatotoxic effect of halothane.	Halothane	61-70	interleukin 17A	Mus musculus	18-23
19633216-9	2009	Administration of recombinant IL-17 (1 microg per mouse, single ip) to the halothane-treated mice resulted in a remarkable increase of alanine and aspartate aminotransferases.	Halothane	75-84	interleukin 17A	Mus musculus	30-35
19633216-10	2009	In conclusion, we demonstrated that IL-17 is involved in the halothane-induced liver injury.	Halothane	61-70	interleukin 17A	Mus musculus	36-41
19697903-3	2009	Using our published open-channel structure model of alpha4beta2 nAChR, we identified and evaluated six amphiphilic interaction sites for the volatile anesthetic halothane via flexible ligand docking and subsequent 20-ns molecular dynamics simulations.	Halothane	161-170	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	64-69
19697903-5	2009	The primary binding sites were located at the interface of extracellular and transmembrane domains, where halothane perturbed conformations of, and widened the gap among, the Cys loop, the beta1-beta2 loop, and the TM2-TM3 linker.	Halothane	106-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	195-200
19697903-6	2009	The halothane with the highest binding affinity at the interface between the alpha4 and beta2 subunits altered interactions between the protein and nearby lipids by competing for hydrogen bonds.	Halothane	4-13	immunoglobulin binding protein 1	Homo sapiens	77-83
19697903-6	2009	The halothane with the highest binding affinity at the interface between the alpha4 and beta2 subunits altered interactions between the protein and nearby lipids by competing for hydrogen bonds.	Halothane	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-93
20023768-7	2009	The MH-triggering volatile anesthetic, halothane, activates RyR1(R615C) and RyR1(WT) to a similar extent, using [(3)H]ryanodine binding as a measure of activation.	Halothane	39-48	ryanodine receptor 1	Homo sapiens	76-80
20023768-8	2009	Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane.	Halothane	229-238	ryanodine receptor 1	Homo sapiens	9-13
20023768-8	2009	Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane.	Halothane	229-238	ryanodine receptor 1	Homo sapiens	9-12
20023768-8	2009	Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane.	Halothane	229-238	ryanodine receptor 1	Homo sapiens	149-153
19237502-5	2009	Exposure of CASQ1-null mice to either 2% halothane or heat stress triggers lethal episodes characterized by whole-body contractures, elevated core temperature, and severe rhabdomyolysis, which are prevented by prior dantrolene administration.	Halothane	41-50	calsequestrin 1	Mus musculus	12-17
19915771-2	2009	We report a 33 year-old female with a diagnosis of halothane-induce fulminant hepatic failure who was subjected to a liver transplant with an ABO-incompatible graft.	Halothane	51-60	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	142-145
19417098-5	2009	Ablation of CASQ1 results in remodelling of the EC coupling apparatus and functional changes, which in male mice causes a striking increase in the rate of spontaneous mortality and susceptibility to trigger MH-like lethal episodes in response to halothane and heat stress.	Halothane	246-255	calsequestrin 1	Mus musculus	12-17
19531722-9	2009	Finally, the halothane screening method used to detect PSE-susceptible live swine does not work when used to screen suspect turkeys or chickens.	Halothane	13-22	PSE	Sus scrofa	55-58
19450488-1	2009	We demonstrate that cyano-phenylalanine (Phe(CN)) can be utilized to probe the binding of the inhalational anesthetic halothane to an anesthetic-binding, model ion channel protein hbAP-Phe(CN).	Halothane	118-127	prohibitin 2	Homo sapiens	180-184
19450488-3	2009	The halothane binding properties of this Phe(CN) mutant hbAP-Phe(CN), based on fluorescence quenching, are consistent with those of the prototype, hbAP1.	Halothane	4-13	prohibitin 2	Homo sapiens	56-60
19450488-3	2009	The halothane binding properties of this Phe(CN) mutant hbAP-Phe(CN), based on fluorescence quenching, are consistent with those of the prototype, hbAP1.	Halothane	4-13	hemoglobin subunit alpha pseudogene 1	Homo sapiens	147-152
19450488-10	2009	hbAP-Phe(CN) therefore provides a successful template for extending these investigations of the interactions of halothane with the model membrane protein via vibrational spectroscopy, using cyano-alanine residues to form the anesthetic binding cavity.	Halothane	112-121	prohibitin 2	Homo sapiens	0-4
19116131-3	2009	Using a nuclear magnetic resonance (NMR) study, we previously demonstrated that at a high concentration (higher than clinically relevant concentrations), the inhaled anesthetics halothane and isoflurane, interact with specific amino acid residues (G29, A30, and I31) and induce Abeta oligomerization.	Halothane	178-187	amyloid beta precursor protein	Homo sapiens	278-283
19556651-8	2009	After an hour of pseudo-operation halothane also induces proved decrease of quantity of GAD65/67 positive cells in CA3 hippocampal field.	Halothane	34-43	glutamate decarboxylase 2	Rattus norvegicus	88-93
19556651-8	2009	After an hour of pseudo-operation halothane also induces proved decrease of quantity of GAD65/67 positive cells in CA3 hippocampal field.	Halothane	34-43	carbonic anhydrase 3	Rattus norvegicus	115-118
19442086-4	2009	Among these, halothane is metabolized by cytochrome P450 (CYP) 2E1 and, to a lesser extent, by CYP3A4 and CYP2A6.	Halothane	13-22	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-66
19442086-4	2009	Among these, halothane is metabolized by cytochrome P450 (CYP) 2E1 and, to a lesser extent, by CYP3A4 and CYP2A6.	Halothane	13-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-101
19442086-4	2009	Among these, halothane is metabolized by cytochrome P450 (CYP) 2E1 and, to a lesser extent, by CYP3A4 and CYP2A6.	Halothane	13-22	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	106-112
18618890-1	2008	The complex of halothane (CF(3)CBrClH) with ([D(3)])methyl fluoride is investigated theoretically by means of ab initio calculations at the MP2/6-311++G(d,p) level and experimentally by infrared spectroscopy of solutions in liquid krypton.	Halothane	15-24	tryptase pseudogene 1	Homo sapiens	140-143
18790008-4	2008	Two weeks later, halothane-anesthetized rats underwent middle cerebral artery (MCA) occlusion by interparenchymal stereotactic injection of the potent vasoconstrictor endothelin 1 (180pmoles/2microl) near the middle cerebral artery.	Halothane	17-26	endothelin 1	Rattus norvegicus	167-179
18478257-8	2008	Together with the dual effect of halothane on I (h) properties, these results suggest that I (h) in TC neurons critically depends on HCN1/HCN2 heterodimers.	Halothane	33-42	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	133-137
18478257-8	2008	Together with the dual effect of halothane on I (h) properties, these results suggest that I (h) in TC neurons critically depends on HCN1/HCN2 heterodimers.	Halothane	33-42	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	138-142
18940183-0	2009	Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration.	Halothane	38-47	interleukin 10	Mus musculus	0-14
18940183-0	2009	Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration.	Halothane	38-47	chemokine (C-X-C motif) ligand 15	Mus musculus	83-96
18940183-2	2009	Using a newly established DILI model induced by halothane, we found increased liver damage susceptibility in interleukin 10 (IL-10) knockout (KO) mice.	Halothane	48-57	interleukin 10	Mus musculus	109-123
18940183-2	2009	Using a newly established DILI model induced by halothane, we found increased liver damage susceptibility in interleukin 10 (IL-10) knockout (KO) mice.	Halothane	48-57	interleukin 10	Mus musculus	125-130
18940183-3	2009	Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration.	Halothane	130-139	chemokine (C-X-C motif) ligand 15	Mus musculus	61-74
18940183-3	2009	Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration.	Halothane	130-139	chemokine (C-X-C motif) ligand 15	Mus musculus	76-80
18940183-3	2009	Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration.	Halothane	130-139	interleukin 10	Mus musculus	96-101
18940183-5	2009	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Halothane	116-125	signal transducer and activator of transcription 3	Mus musculus	81-85
18940183-5	2009	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Halothane	116-125	signal transducer and activator of transcription 3	Mus musculus	93-98
18940183-5	2009	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Halothane	116-125	interleukin 10	Mus musculus	134-139
18940183-6	2009	Exogenous IL-10 treatment protected susceptible mice from halothane induced liver injury (HILI).	Halothane	58-67	interleukin 10	Mus musculus	10-15
18533074-7	2008	RESULTS: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group.	Halothane	172-181	hematopoietic prostaglandin D synthase	Rattus norvegicus	95-120
18305228-2	2008	In MH-susceptible skeletal fibers, RyR1-mediated Ca(2+) release is highly sensitive to activation by the volatile anesthetic halothane.	Halothane	125-134	ryanodine receptor 1	Oryctolagus cuniculus	35-39
18505726-6	2008	Furthermore, the MH-triggering agent, halothane, potentiated the response of RyR1 to luminal Ca(2+) and SOICR.	Halothane	38-47	ryanodine receptor 1	Homo sapiens	77-81
18304776-1	2008	Previous studies demonstrated significantly lower plasma cortisol level in homozygous halothane-positive (Hal nn) pigs, as compared with homozygous halothane-negative (Hal NN) pigs.	Halothane	86-95	histidine ammonia-lyase	Sus scrofa	106-109
18310239-6	2008	Hydrophobic interactions with residues A44 and L18 also contribute to stabilizing the bound halothane.	Halothane	92-101	ribosomal protein L18	Homo sapiens	47-50
18431124-4	2008	RESULTS: Systemically injected fusion peptide Tat-PSD-95 PDZ2 was delivered into the central nervous system, disrupted the protein-protein interactions between N-methyl-d-aspartate receptor NR2 subunits and PSD-95, and significantly reduced the minimum alveolar anesthetic concentration and righting reflex EC50 for halothane.	Halothane	316-325	discs large MAGUK scaffold protein 4	Mus musculus	50-56
18431124-5	2008	CONCLUSIONS: By disrupting PSD-95 PDZ2 domain-mediated protein interactions, intraperitoneal injection of cell-permeant fusion peptide Tat-PSD-95 PDZ2 dose-dependently reduces the threshold for halothane anesthesia.	Halothane	194-203	discs large MAGUK scaffold protein 4	Mus musculus	27-33
18431124-5	2008	CONCLUSIONS: By disrupting PSD-95 PDZ2 domain-mediated protein interactions, intraperitoneal injection of cell-permeant fusion peptide Tat-PSD-95 PDZ2 dose-dependently reduces the threshold for halothane anesthesia.	Halothane	194-203	discs large MAGUK scaffold protein 4	Mus musculus	139-145
18305228-11	2008	Studies with skeletal SR microsomes confirmed that halothane-induced RyR1-mediated SR Ca(2+) release is enhanced by high ATP-low Mg(2+) in the cytosol and by increased SR Ca(2+) load.	Halothane	51-60	ryanodine receptor 1	Oryctolagus cuniculus	69-73
18305228-12	2008	Thus, physiological or pathological processes that induce changes in cellular levels of these modulators could affect RyR1 sensitivity to halothane in skeletal fibers, including the outcome of halothane-induced contracture tests used to diagnose MH susceptibility.	Halothane	138-147	ryanodine receptor 1	Oryctolagus cuniculus	118-122
18305228-3	2008	Indeed, studies with isolated RyR1 channels (using simple Cs(+) solutions) found that halothane selectively affects mutated but not wild-type RyR1 function.	Halothane	86-95	ryanodine receptor 1	Oryctolagus cuniculus	30-34
18305228-3	2008	Indeed, studies with isolated RyR1 channels (using simple Cs(+) solutions) found that halothane selectively affects mutated but not wild-type RyR1 function.	Halothane	86-95	ryanodine receptor 1	Oryctolagus cuniculus	142-146
18305228-4	2008	However, studies in skeletal fibers indicate that halothane can also activate wild-type RyR1-mediated Ca(2+) release.	Halothane	50-59	ryanodine receptor 1	Oryctolagus cuniculus	88-92
18305228-5	2008	We hypothesized that endogenous RyR1 agonists (ATP, lumenal Ca(2+)) may increase RyR1 sensitivity to halothane.	Halothane	101-110	ryanodine receptor 1	Oryctolagus cuniculus	32-36
18305228-5	2008	We hypothesized that endogenous RyR1 agonists (ATP, lumenal Ca(2+)) may increase RyR1 sensitivity to halothane.	Halothane	101-110	ryanodine receptor 1	Oryctolagus cuniculus	81-85
18305228-6	2008	Consequently, we studied how these agonists affect halothane action on rabbit skeletal RyR1 reconstituted into planar lipid bilayers.	Halothane	51-60	ryanodine receptor 1	Oryctolagus cuniculus	87-91
18305228-7	2008	We found that cytosolic ATP is required for halothane-induced activation of the skeletal RyR1.	Halothane	44-53	ryanodine receptor 1	Oryctolagus cuniculus	89-93
18305228-8	2008	Unlike RyR1, cardiac RyR2 (much less sensitive to ATP) responded to halothane even in the absence of this agonist.	Halothane	68-77	ryanodine receptor 2	Oryctolagus cuniculus	21-25
18305228-9	2008	ATP-dependent halothane activation of RyR1 was enhanced by cytosolic Ca(2+) (channel agonist) and counteracted by Mg(2+) (channel inhibitor).	Halothane	14-23	ryanodine receptor 1	Oryctolagus cuniculus	38-42
17828284-6	2007	TREK-1 deletion also reduced halothane inhibition of basal glutamate release, but did not affect basal GABA release.	Halothane	29-38	potassium channel, subfamily K, member 2	Mus musculus	0-6
18204473-0	2008	Modulation of TRPC5 cation channels by halothane, chloroform and propofol.	Halothane	39-48	transient receptor potential cation channel subfamily C member 5	Homo sapiens	14-19
18204473-3	2008	Here we report the effects of inhalational (halothane and chloroform) and intravenous (propofol) general anaesthetics upon TRPC5.	Halothane	44-53	transient receptor potential cation channel subfamily C member 5	Homo sapiens	123-128
18204473-6	2008	KEY RESULTS: TRPC5 activation by carbachol, Gd3+ or LPC was inhibited by halothane and chloroform at &gt; or =0.1 and 0.2 mM respectively.	Halothane	73-82	transient receptor potential cation channel subfamily C member 5	Homo sapiens	13-18
18430952-6	2008	A chromosome scan was conducted for a meat quality trait in an F(2) intercross in pigs where a mutation in the halothane (Ryanodine receptor, RYR1) gene with a large effect on meat quality was known to segregate in one founder line.	Halothane	111-120	ryanodine receptor 1	Sus scrofa	142-146
17828284-0	2007	Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.	Halothane	61-70	potassium channel, subfamily K, member 2	Mus musculus	103-109
17828284-5	2007	KEY RESULTS: Deletion of TREK-1 significantly reduced the potency of halothane inhibition of 4-aminopyridine-evoked release of both glutamate and GABA without affecting control evoked release or the selective inhibition of glutamate vs GABA release.	Halothane	69-78	potassium channel, subfamily K, member 2	Mus musculus	25-31
17828284-7	2007	CONCLUSIONS AND IMPLICATIONS: The reduced sensitivity of glutamate and GABA release to inhibition by halothane in TREK-1 KO nerve terminals correlates with the reduced anaesthetic potency of halothane in TREK-1 KO mice observed in vivo.	Halothane	101-110	potassium channel, subfamily K, member 2	Mus musculus	114-120
17828284-7	2007	CONCLUSIONS AND IMPLICATIONS: The reduced sensitivity of glutamate and GABA release to inhibition by halothane in TREK-1 KO nerve terminals correlates with the reduced anaesthetic potency of halothane in TREK-1 KO mice observed in vivo.	Halothane	101-110	potassium channel, subfamily K, member 2	Mus musculus	204-210
17828284-7	2007	CONCLUSIONS AND IMPLICATIONS: The reduced sensitivity of glutamate and GABA release to inhibition by halothane in TREK-1 KO nerve terminals correlates with the reduced anaesthetic potency of halothane in TREK-1 KO mice observed in vivo.	Halothane	191-200	potassium channel, subfamily K, member 2	Mus musculus	114-120
17828284-7	2007	CONCLUSIONS AND IMPLICATIONS: The reduced sensitivity of glutamate and GABA release to inhibition by halothane in TREK-1 KO nerve terminals correlates with the reduced anaesthetic potency of halothane in TREK-1 KO mice observed in vivo.	Halothane	191-200	potassium channel, subfamily K, member 2	Mus musculus	204-210
17699638-1	2007	Volatile anesthetics have been shown to activate various two-pore (2P) domain K(+) (K(2P)) channels such as TASK-1 and TREK-1 (TWIK-related acid-sensitive K(+) channel), and mice deficient in these channels are resistant to halothane-induced anesthesia.	Halothane	224-233	keratin 76	Homo sapiens	84-89
17880365-7	2007	In the present study, we investigated the effect of anaesthetics (thiopental, ketamine and halothane) on CSF concentrations of S100B, as well as a possible sex dependence, because several studies have suggested astrocytes as putative targets for oestrogen.	Halothane	91-100	S100 calcium binding protein B	Rattus norvegicus	127-132
17699638-1	2007	Volatile anesthetics have been shown to activate various two-pore (2P) domain K(+) (K(2P)) channels such as TASK-1 and TREK-1 (TWIK-related acid-sensitive K(+) channel), and mice deficient in these channels are resistant to halothane-induced anesthesia.	Halothane	224-233	potassium channel, subfamily K, member 2	Mus musculus	119-125
17259327-5	2007	To test this hypothesis, we have performed a comprehensive histologic study of the effects of ET-1 when applied topically to the cerebral cortex of halothane-anesthetized rats.	Halothane	148-157	endothelin 1	Rattus norvegicus	94-98
17680357-6	2007	These data suggest that [(3)H]DA release induced by halothane is non-vesicular and would be mediated by the dopamine transporter (DAT) and norepinephrine transporter (NET).	Halothane	52-61	solute carrier family 6 member 3	Rattus norvegicus	108-128
17680357-6	2007	These data suggest that [(3)H]DA release induced by halothane is non-vesicular and would be mediated by the dopamine transporter (DAT) and norepinephrine transporter (NET).	Halothane	52-61	solute carrier family 6 member 3	Rattus norvegicus	130-133
17680357-6	2007	These data suggest that [(3)H]DA release induced by halothane is non-vesicular and would be mediated by the dopamine transporter (DAT) and norepinephrine transporter (NET).	Halothane	52-61	solute carrier family 6 member 2	Rattus norvegicus	139-165
17680357-7	2007	GBR 12909 and nomifensine, inhibitors of DAT, decreased the release of [(3)H]DA evoked by halothane.	Halothane	90-99	solute carrier family 6 member 3	Rattus norvegicus	41-44
17592348-2	2007	This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage.	Halothane	108-117	nuclear factor kappa B subunit 1	Homo sapiens	151-154
17592348-6	2007	P50 in the thiopental, propofol, and halothane groups were estimated to be 8.4, 6.5 (P&lt;0.05, vs. thiopental), and 5.1 (P&lt;0.05) minutes, respectively.	Halothane	37-46	nuclear factor kappa B subunit 1	Homo sapiens	0-3
17492702-1	2007	The complex of halothane (CHClBrCF(3)) and dimethyl ether has been investigated experimentally in solutions of liquid krypton using infrared spectroscopy and theoretically using ab initio calculations at the MP2/6-311++G(d,p) level.	Halothane	15-24	tryptase pseudogene 1	Homo sapiens	208-211
17202397-3	2007	We hypothesize that the presence of the halothane gene accelerates energy consumption in postmortem muscle, which activates adenosine monophosphate-activated protein kinase (AMPK), leading to enhanced glycolysis and PSE meat.	Halothane	40-49	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	124-172
17202397-3	2007	We hypothesize that the presence of the halothane gene accelerates energy consumption in postmortem muscle, which activates adenosine monophosphate-activated protein kinase (AMPK), leading to enhanced glycolysis and PSE meat.	Halothane	40-49	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	174-178
17202397-6	2007	In addition, an early AMPK activation was observed in LM from halothane carriers.	Halothane	62-71	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	22-26
17202397-9	2007	In summary, this study showed that the presence of the halothane gene induced early energy depletion, which could be a primary reason causing AMPK activation, leading to accelerated glycolysis and an increased incidence of PSE meat.	Halothane	55-64	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	142-146
17824463-4	2007	The results obtained depict that the formation of malonyl dialdehyde as well as decrease in superoxide dismutase and catalase activities was highest in spinal anaesthesia followed by halothane and then relaxant group.	Halothane	183-192	catalase	Homo sapiens	117-125
17242089-0	2007	Halothane, isoflurane, and sevoflurane increase the kinetics of Ca2+-induced conformational change of recombinant human cardiac troponin C.	Halothane	0-9	troponin C1, slow skeletal and cardiac type	Homo sapiens	120-138
17680357-12	2007	It is suggested that halothane increases [(3)H]DA release in brain cortical slices that is mediated by DAT and NET present in the plasma membrane.	Halothane	21-30	solute carrier family 6 member 3	Rattus norvegicus	103-106
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Halothane	170-179	keratin 76	Homo sapiens	31-34
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Halothane	170-179	potassium two pore domain channel subfamily K member 2	Homo sapiens	83-87
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Halothane	170-179	potassium two pore domain channel subfamily K member 2	Homo sapiens	100-106
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Halothane	170-179	potassium two pore domain channel subfamily K member 10	Homo sapiens	111-117
17197033-0	2007	Detrimental effects of halothane narcosis on damage after endothelin-1-induced MCAO.	Halothane	23-32	endothelin 1	Rattus norvegicus	58-70
16815980-7	2006	Additional electrophysiological and molecular studies showed that pH- and halothane-sensitive two-pore domain weakly inward rectifying K(+) channel (TWIK)-like acid-sensitive K(+) (TASK) channel subtypes were functionally expressed in aortas, and TASK1 expression was significantly higher in WKY than in SHR.	Halothane	74-83	potassium two pore domain channel subfamily K member 1	Rattus norvegicus	149-153
17622749-4	2007	METHODS AND RESULTS: In human proximal tubule (HK-2) cell culture, 16-hour exposure to volatile anesthetics (isoflurane, halothane, sevoflurane) caused membrane externalization of PS detected by positive annexin-V staining and increased the release of TGF-beta1 into the cell culture media.	Halothane	121-130	annexin A5	Homo sapiens	204-213
17622749-4	2007	METHODS AND RESULTS: In human proximal tubule (HK-2) cell culture, 16-hour exposure to volatile anesthetics (isoflurane, halothane, sevoflurane) caused membrane externalization of PS detected by positive annexin-V staining and increased the release of TGF-beta1 into the cell culture media.	Halothane	121-130	transforming growth factor beta 1	Homo sapiens	252-261
16855789-5	2007	Our results imply that physiologically relevant concentrations of halothane disrupt focal adhesion contacts in A 549 cells, which is accompanied with suppression of focal adhesion kinase activity and paxillin phosphorylation, and not with proteolytic changes or inhibition of vinculin and paxillin expression.We suggest that at least one of the toxic effects of halothane is due to a decreased phosphorylation of the focal contact proteins.	Halothane	66-75	vinculin	Homo sapiens	276-284
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	tumor necrosis factor	Mus musculus	67-94
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	tumor necrosis factor	Mus musculus	96-105
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	interleukin 1 beta	Mus musculus	108-125
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	interleukin 1 beta	Mus musculus	127-135
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	interleukin 6	Mus musculus	138-142
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	chemokine (C-X-C motif) ligand 15	Mus musculus	148-152
16965849-5	2006	Halothane induced a marked activation of NF-kappaB (+180%), and resulted in a significant decrease of the nonphosphorylated form of the inhibitor IkappaBalpha (-53%), while phosphorylated IkappaBalpha protein level was markedly increased (+146%).	Halothane	0-9	NFKB inhibitor alpha	Rattus norvegicus	146-158
17242473-4	2006	The most pronounced enhancement of LE, which may reflect a tendency to lymphocyte cytolysis, was found in the recessive homozygotes RyR1 (nn) phenotypically defined as stress/halothane susceptible as well as in the heterozygotes RyR1 (Nn) included in the group of stress/halothane resistant.	Halothane	175-184	ryanodine receptor 1	Sus scrofa	132-136
16965849-5	2006	Halothane induced a marked activation of NF-kappaB (+180%), and resulted in a significant decrease of the nonphosphorylated form of the inhibitor IkappaBalpha (-53%), while phosphorylated IkappaBalpha protein level was markedly increased (+146%).	Halothane	0-9	NFKB inhibitor alpha	Rattus norvegicus	188-200
16965849-7	2006	The increase of iNOS protein level (+59%) induced by halothane was significantly reduced to +22% by additional administration of propofol.	Halothane	53-62	nitric oxide synthase 2	Rattus norvegicus	16-20
16965849-8	2006	Results obtained show that administration of propofol inhibits oxidative stress, NF-kappaB nuclear traslocation and iNOS overexpression in liver of rats receiving halothane.	Halothane	163-172	nitric oxide synthase 2	Rattus norvegicus	116-120
16931689-5	2006	Furthermore, when anesthetized with a mixture of halothane and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice.	Halothane	49-58	pro-opiomelanocortin-alpha	Mus musculus	159-186
16923096-6	2006	RESULTS: Electrical stimulation in the reticular formation increased the spectral edge (SEF) and median edge (MEF) frequencies by approximately 1-2 Hz during halothane anesthesia at low and high concentrations.	Halothane	158-167	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	110-113
16931689-5	2006	Furthermore, when anesthetized with a mixture of halothane and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice.	Halothane	49-58	crystallin, gamma B	Mus musculus	205-208
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	ribosomal protein S6 kinase B1	Homo sapiens	432-436
16849381-0	2006	Mg2+ dependence of Ca2+ release from the sarcoplasmic reticulum induced by sevoflurane or halothane in skeletal muscle from humans susceptible to malignant hyperthermia.	Halothane	90-99	mucin 7, secreted	Homo sapiens	0-3
16871065-1	2006	BACKGROUND: Halothane inhibits airway smooth muscle contraction in part by inhibiting the functional coupling between muscarinic receptors and one of its cognate heterotrimeric G proteins, Galphaq.	Halothane	12-21	G protein subunit alpha q	Homo sapiens	189-196
16871065-9	2006	CONCLUSION: The differential effects of volatile anesthetics on acetylcholine-promoted guanosine nucleotide exchange at Galphaq are consistent with the apparent more potent direct effect of halothane and sevoflurane compared with isoflurane on muscarinic receptor-mediated contraction of isolated airway smooth muscle.	Halothane	190-199	G protein subunit alpha q	Homo sapiens	120-127
16434554-6	2006	At 6% halothane, a rapid and persistent increase in phosphorylation of the alpha-subunit of eukaryotic translation initiation factor (eIF)2 occurs.	Halothane	6-15	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	134-139
16807784-0	2006	Alzheimer"s disease: halothane induces Abeta peptide to oligomeric form--solution NMR studies.	Halothane	21-30	amyloid beta precursor protein	Homo sapiens	39-44
16807784-6	2006	Halothane induces structural alternation of Abeta peptide from soluble monomeric alpha-helical form to oligomeric beta-sheet conformation, which may hasten the onset of AD.	Halothane	0-9	amyloid beta precursor protein	Homo sapiens	44-49
16807784-8	2006	The molecular mechanism of halothane induced structural alternation of Abeta peptide is discussed.	Halothane	27-36	amyloid beta precursor protein	Homo sapiens	71-76
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	eukaryotic translation initiation factor 4E	Homo sapiens	152-157
16571971-1	2006	BACKGROUND: This study investigated whether halothane affects the functional coupling between the beta2 adrenergic receptor and the alpha subunit of its cognate stimulatory heterotrimeric guanosine-5"-triphosphate (GTP)-binding protein (Galphas).	Halothane	44-53	adrenoceptor beta 2	Homo sapiens	98-123
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	208-213
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	255-285
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	ribosomal protein S6	Homo sapiens	316-336
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	ribosomal protein S6	Homo sapiens	338-342
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	ribosomal protein S6	Homo sapiens	422-426
16434554-9	2006	After extended exposure to 6% halothane, alterations in two separate responses regulated by the target of rapamycin pathway occur: 1) redistribution of eIF4E from its translation-stimulatory association with eIF4G to its translation-inactive complex with eIF4E-binding protein-1; and 2) decreased phosphorylation of ribosomal protein S6 (rpS6) with a corresponding decrease in active forms of a kinase that phosphorylates rpS6 (p70(S6K1)).	Halothane	30-39	annexin A6	Homo sapiens	428-431
16192769-3	2005	Motivated by this hypothesis, the authors measured the ability of syntaxin 1A and proteins that interact with syntaxin to bind to halothane and isoflurane.	Halothane	130-139	syntaxin 1A	Rattus norvegicus	66-77
16543580-1	2006	The objective of this study was to determine if HAL-1843-normal pigs that respond abnormally to halothane anesthesia were more likely to become nonambulatory (NA) when subjected to rigorous handling than pigs that exhibit a normal response to halothane.	Halothane	96-105	histidine ammonia-lyase	Sus scrofa	48-51
16543580-1	2006	The objective of this study was to determine if HAL-1843-normal pigs that respond abnormally to halothane anesthesia were more likely to become nonambulatory (NA) when subjected to rigorous handling than pigs that exhibit a normal response to halothane.	Halothane	243-252	histidine ammonia-lyase	Sus scrofa	48-51
16243998-8	2005	Although none of the drugs examined had any effect on the alpha2-ARs, the physiological actions of the alpha2-ARs mediated by the GIRK1/GIRK2 channels may be affected by ethanol and halothane.	Halothane	182-191	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	103-109
16243998-8	2005	Although none of the drugs examined had any effect on the alpha2-ARs, the physiological actions of the alpha2-ARs mediated by the GIRK1/GIRK2 channels may be affected by ethanol and halothane.	Halothane	182-191	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	130-135
16262664-8	2005	Many p-ERK1/2-ir VLM neurons were catecholaminergic following halothane or sodium pentobarbital anaesthesia, but no double labelling was seen following cervical dislocation.	Halothane	62-71	mitogen activated protein kinase 3	Rattus norvegicus	7-13
16192517-2	2005	Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic-activated K2P channel yet described.	Halothane	37-46	potassium two pore domain channel subfamily K member 18	Homo sapiens	6-11
16192517-2	2005	Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic-activated K2P channel yet described.	Halothane	37-46	keratin 76	Homo sapiens	148-151
16428544-6	2006	In addition, PCO2 was measured in the halothane experiments.	Halothane	38-47	PCO2	Sus scrofa	13-17
16306727-2	2005	To explore the role of voltage-dependent inactivation, the authors analyzed halothane effects on recombinant cardiac L-type calcium channels (alpha1Cbeta2a and alpha1Cbeta2aalpha2/delta1), which differ by the alpha2/delta1 subunit and consequently voltage-dependent inactivation.	Halothane	76-85	delta like non-canonical Notch ligand 1	Homo sapiens	173-186
16306727-8	2005	CONCLUSIONS: The results indicate that phenotypic features arising from alpha2/delta1 coexpression play a key role in halothane inhibition of cardiac L-type calcium channels.	Halothane	118-127	delta like non-canonical Notch ligand 1	Homo sapiens	72-85
15994848-6	2005	Halothane (0.6 mM) inhibited outward I(NCX) at voltages positive to -10 mV and inward I(NCX) at voltages negative to -80 mV (P&lt;0.05, n=10; I(NCX) reduced by 64% at +50 and 65% of control at -120 mV).	Halothane	0-9	solute carrier family 8 member A1	Rattus norvegicus	37-43
16040747-1	2005	The nature and the sites of interactions between anesthetic halothane and homodimeric Delta5-3-ketosteroid isomerase (KSI) are characterized by flexible ligand docking and confirmed by 1H-15N NMR.	Halothane	60-69	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	92-116
16040747-1	2005	The nature and the sites of interactions between anesthetic halothane and homodimeric Delta5-3-ketosteroid isomerase (KSI) are characterized by flexible ligand docking and confirmed by 1H-15N NMR.	Halothane	60-69	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	118-121
16040747-3	2005	Both docking and MD simulations show that halothane prefer the amphiphilic dimeric interface to the hydrophobic active site of KSI.	Halothane	42-51	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	127-130
16040747-8	2005	The allosteric halothane modulation of the dynamics-function relationship of KSI without direct competition at the enzymatic active sites may be generalized to offer a unifying explanation of anesthetic action on a diverse range of multidomain neuronal proteins that are potentially relevant to clinical general anesthesia.	Halothane	15-24	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	77-80
15994848-8	2005	CONCLUSIONS: Inhibition of Ca2+ efflux via NCX (i.e. inward I(NCX)) during an exposure to halothane or sevoflurane would be expected to limit the negative inotropic effects of these agents and help maintain SR Ca2+ content.	Halothane	90-99	solute carrier family 8 member A1	Rattus norvegicus	53-66
15994848-6	2005	Halothane (0.6 mM) inhibited outward I(NCX) at voltages positive to -10 mV and inward I(NCX) at voltages negative to -80 mV (P&lt;0.05, n=10; I(NCX) reduced by 64% at +50 and 65% of control at -120 mV).	Halothane	0-9	solute carrier family 8 member A1	Rattus norvegicus	86-92
15994848-6	2005	Halothane (0.6 mM) inhibited outward I(NCX) at voltages positive to -10 mV and inward I(NCX) at voltages negative to -80 mV (P&lt;0.05, n=10; I(NCX) reduced by 64% at +50 and 65% of control at -120 mV).	Halothane	0-9	solute carrier family 8 member A1	Rattus norvegicus	86-92
15994848-8	2005	CONCLUSIONS: Inhibition of Ca2+ efflux via NCX (i.e. inward I(NCX)) during an exposure to halothane or sevoflurane would be expected to limit the negative inotropic effects of these agents and help maintain SR Ca2+ content.	Halothane	90-99	solute carrier family 8 member A1	Rattus norvegicus	43-46
15976221-7	2005	A Q/R mutation that dominantly affects kainate receptors containing the GluR6 subunit in mice increased isoflurane minimum alveolar concentration (by 12%; P &lt; 0.01), decreased desflurane minimum alveolar concentration (by 18%; P &lt; 0.001), and did not change halothane minimum alveolar concentration (P = 0.25).	Halothane	264-273	glutamate receptor, ionotropic, kainate 2 (beta 2)	Mus musculus	72-77
15923266-4	2005	METHODS: We analysed the effects of halothane and isoflurane on the binding of purified recombinant rat synaptotagmin 1 C2A, C2B and C2AB domains to radiolabelled phospholipid liposomes.	Halothane	36-45	synaptotagmin 1	Rattus norvegicus	104-119
15954957-6	2005	RESULTS: MACs for halothane, isoflurane and sevoflurane in NOP-/- mice were 1.60 (SD 0.06), 1.68 (0.08) and 3.36 (0.07)%, respectively.	Halothane	18-27	crystallin, gamma B	Mus musculus	59-62
15983461-9	2005	Halothane and isoflurane (0.5-1.5 MAC) significantly inhibited NCX (P &lt; 0.05; paired comparisons), whereas sevoflurane at less than 1.5 MAC did not inhibit NCX.	Halothane	0-9	solute carrier family 8 member A1	Rattus norvegicus	63-66
15983461-12	2005	CONCLUSIONS: These data indicate that volatile anesthetics, especially halothane and isoflurane, interfere with neuronal [Ca2+]i regulation by inhibiting NCX but not SOCC-mediated Ca2+ influx (except high concentrations of halothane).	Halothane	71-80	solute carrier family 8 member A1	Rattus norvegicus	154-157
15826301-9	2005	RESULTS: Halothane pre-treated rat HECs released significantly greater TNF-alpha concentration following MAA-adduct and LPS stimulation than the non-halothane pre-treated in both pair and alcohol-fed rats, but was significantly greater in the alcohol-fed rats.	Halothane	9-18	tumor necrosis factor	Rattus norvegicus	71-80
15826301-10	2005	CONCLUSION: These results demonstrate that halothane and MAA-adduct pre-treatment increases the inflammatory response (TNF-alpha release).	Halothane	43-52	tumor necrosis factor	Rattus norvegicus	119-128
15826301-11	2005	Also, these results suggest that halothane exposure may increase the risk of alcohol-induced heart injury, since halothane pre-treatment potentiates the HEC TNF-alpha release measured following both MAA-Alb and LPS stimulation.	Halothane	33-42	tumor necrosis factor	Rattus norvegicus	157-166
15826301-11	2005	Also, these results suggest that halothane exposure may increase the risk of alcohol-induced heart injury, since halothane pre-treatment potentiates the HEC TNF-alpha release measured following both MAA-Alb and LPS stimulation.	Halothane	33-42	albumin	Rattus norvegicus	203-206
15826301-11	2005	Also, these results suggest that halothane exposure may increase the risk of alcohol-induced heart injury, since halothane pre-treatment potentiates the HEC TNF-alpha release measured following both MAA-Alb and LPS stimulation.	Halothane	113-122	tumor necrosis factor	Rattus norvegicus	157-166
15826301-11	2005	Also, these results suggest that halothane exposure may increase the risk of alcohol-induced heart injury, since halothane pre-treatment potentiates the HEC TNF-alpha release measured following both MAA-Alb and LPS stimulation.	Halothane	113-122	albumin	Rattus norvegicus	203-206
15791007-4	2005	The crystal structures of the halothane/apoferritin and isoflurane/apoferritin complexes were determined at 1.75 A resolution, revealing a common anesthetic binding pocket within an interhelical dimerization interface.	Halothane	30-39	ferritin heavy chain 1	Homo sapiens	40-51
15576447-1	2005	The cytochrome P450 (P450) CYP2E1 enzyme metabolizes and activates a wide array of toxicological substrates, including alcohols, the widely used analgesic acetaminophen, acetone, benzene, halothane, and carcinogens such as azoxymethane and dimethylhydrazine.	Halothane	188-197	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	27-33
15618790-13	2005	CONCLUSIONS: Isoflurane, sevoflurane, and halothane potently blocked the alpha4beta2 nAChR.	Halothane	42-51	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	85-90
15826301-0	2005	Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells.	Halothane	0-9	tumor necrosis factor	Rattus norvegicus	49-58
15659239-5	2005	Furthermore, three anesthetics, pentobarbital, halothane and chloral hydrate, each caused large in vivo increases in the serine phosphorylation of both GSK3beta and GSK3alpha in several regions of mouse brain.	Halothane	47-56	glycogen synthase kinase 3 beta	Mus musculus	152-160
15659239-5	2005	Furthermore, three anesthetics, pentobarbital, halothane and chloral hydrate, each caused large in vivo increases in the serine phosphorylation of both GSK3beta and GSK3alpha in several regions of mouse brain.	Halothane	47-56	glycogen synthase kinase 3 alpha	Mus musculus	165-174
15483066-3	2005	In this study, using intracellular recording and staining in vivo technique, we show a late depolarizing postsynaptic potential (L-PSP) in CA1 pyramidal neurons of adult Wistar rats under halothane anesthesia.	Halothane	188-197	persephin	Rattus norvegicus	131-134
15483066-3	2005	In this study, using intracellular recording and staining in vivo technique, we show a late depolarizing postsynaptic potential (L-PSP) in CA1 pyramidal neurons of adult Wistar rats under halothane anesthesia.	Halothane	188-197	carbonic anhydrase 1	Rattus norvegicus	139-142
15621044-9	2005	Subsequent introduction of halothane (0.5-1 mM) induced a transient burst of Ca(2+) sparks, consistent with ryanodine receptor (RyR) activation.	Halothane	27-36	ryanodine receptor 2	Rattus norvegicus	108-126
15621044-9	2005	Subsequent introduction of halothane (0.5-1 mM) induced a transient burst of Ca(2+) sparks, consistent with ryanodine receptor (RyR) activation.	Halothane	27-36	ryanodine receptor 2	Rattus norvegicus	128-131
15621044-12	2005	CONCLUSIONS: These data suggest that the sensitivity of the RyR to activation by halothane increases at low [ATP].	Halothane	81-90	ryanodine receptor 2	Rattus norvegicus	60-63
15674517-4	2005	We previously reported that halothane inhibits the hypoxia-induced HIF-1 activation.	Halothane	28-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
15747502-9	2005	Some drugs such as anticonvulsants (phenobarbital, phenytoin, and carbamazepine) and halothane are suggested to induce hepatitis with anti-CYP3A and anti-CYP2E1, respectively.	Halothane	85-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-144
15747502-9	2005	Some drugs such as anticonvulsants (phenobarbital, phenytoin, and carbamazepine) and halothane are suggested to induce hepatitis with anti-CYP3A and anti-CYP2E1, respectively.	Halothane	85-94	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	154-160
15562501-3	2005	In this study, pyruvate carboxylase flux was assessed during intravenous infusion of [2-(13)C]glucose using localized (1)H-[(13)C] NMR spectroscopy at 7 Tesla in vivo in halothane-anesthetized and ventilated adult Wistar rats during 85 min of bicuculline-induced seizures (1 mg/kg, intravenously) and in nontreated controls.	Halothane	170-179	pyruvate carboxylase	Rattus norvegicus	15-35
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Halothane	343-352	potassium two pore domain channel subfamily K member 2	Homo sapiens	37-43
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Halothane	343-352	potassium two pore domain channel subfamily K member 2	Homo sapiens	59-64
15505644-9	2004	Halothane induction led to a significant drop in SBP, DBP and MAP in all patients at the end of induction.	Halothane	0-9	selenium binding protein 1	Homo sapiens	49-52
16154284-3	2005	THIK-1 expression conferred a moderately outwardly rectifying halothane-inhibited and arachidonic acid-potentiated K+ current and invoked a strongly hyperpolarized resting membrane potential.	Halothane	62-71	potassium two pore domain channel subfamily K member 13	Homo sapiens	0-6
16154284-5	2005	Hypoxia (P(O2), 20 mmHg) reversibly inhibited THIK-1 currents and caused membrane depolarization, effects that were occluded by halothane.	Halothane	128-137	potassium two pore domain channel subfamily K member 13	Homo sapiens	46-52
15880636-2	2005	Ionized halothane (M+*) reacts with neutral halothane to form the ionized olefin [ClBrC=CF2]+*.	Halothane	8-17	ATPase H+ transporting accessory protein 1	Homo sapiens	88-91
15880636-2	2005	Ionized halothane (M+*) reacts with neutral halothane to form the ionized olefin [ClBrC=CF2]+*.	Halothane	44-53	ATPase H+ transporting accessory protein 1	Homo sapiens	88-91
15564941-0	2004	Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in skeletal muscle from humans susceptible to malignant hyperthermia.	Halothane	19-28	mucin 7, secreted	Homo sapiens	0-3
15491783-4	2004	New data derived from studies of knockout animals suggest that TREK-1 might have an important role in the general anaesthetic properties of volatile agents, such as halothane, and provide an explanation for the neuroprotective properties of polyunsaturated fatty acids.	Halothane	165-174	potassium two pore domain channel subfamily K member 2	Homo sapiens	63-69
15385643-6	2004	STD was able to identify that volatile anesthetics bind to bovine serum albumin, oleic acid reduces halothane binding to bovine serum albumin, and halothane binds to apomyoglobin but not lysozyme.	Halothane	100-109	albumin	Homo sapiens	128-141
15140906-10	2004	In contrast, halothane (&lt; or = approximately 17 mM), which acts on TREK-1 and TASK-1 channels, blocked acid taste responses.	Halothane	13-22	potassium channel, subfamily K, member 2	Mus musculus	70-76
15562060-5	2004	With both whole-cell voltage-clamp and patch-clamp recording, TRESK currents increased up to three-fold by clinical concentrations of isoflurane, halothane, sevoflurane, and desflurane.	Halothane	146-155	potassium two pore domain channel subfamily K member 18	Homo sapiens	62-67
15449957-2	2004	Binding to serum albumin is exothermic, yielding enthalpies (DeltaH(obs)) of -3 to -6 kcal/mol for BSA with a rank order of apparent equilibrium association constants (K(a) values): desflurane &gt; isoflurane approximately enflurane &gt; halothane &gt;or= sevoflurane, with the differences being largely ascribed to entropic contributions.	Halothane	238-247	albumin	Bos taurus	11-24
15155283-3	2004	Recordings were made from CCK-sensitive RVLM presympathetic vasomotor neurons in halothane-anesthetized, paralyzed male Sprague-Dawley rats.	Halothane	81-90	cholecystokinin	Rattus norvegicus	26-29
15524207-0	2004	Application of the 19F NMR technique to observe binding of the general anesthetic halothane to human serum albumin.	Halothane	82-91	albumin	Homo sapiens	101-114
15524207-1	2004	19F NMR techniques were employed to characterize the binding property of the widely used general anesthetic halothane with human serum albumin (HSA).	Halothane	108-117	albumin	Homo sapiens	129-142
15505644-9	2004	Halothane induction led to a significant drop in SBP, DBP and MAP in all patients at the end of induction.	Halothane	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	54-57
15339022-4	2004	Halothane and succinylcholine have been used within the pork industry to identify animals susceptible to stress and prone to developing PSE meat.	Halothane	0-9	PSE	Sus scrofa	136-139
15306118-3	2004	The deduced amino acid sequence is homologous to channels of the mammalian two-pore domain halothane inhibited (THIK) subfamily, bearing 46% identity to THIK-1 (KCNK 13) and 48% to THIK-2 (KCNK12).	Halothane	91-100	potassium two pore domain channel subfamily K member 13	Homo sapiens	153-159
15306118-3	2004	The deduced amino acid sequence is homologous to channels of the mammalian two-pore domain halothane inhibited (THIK) subfamily, bearing 46% identity to THIK-1 (KCNK 13) and 48% to THIK-2 (KCNK12).	Halothane	91-100	potassium two pore domain channel subfamily K member 13	Homo sapiens	161-168
15306118-3	2004	The deduced amino acid sequence is homologous to channels of the mammalian two-pore domain halothane inhibited (THIK) subfamily, bearing 46% identity to THIK-1 (KCNK 13) and 48% to THIK-2 (KCNK12).	Halothane	91-100	potassium two pore domain channel subfamily K member 12	Homo sapiens	181-187
15306118-3	2004	The deduced amino acid sequence is homologous to channels of the mammalian two-pore domain halothane inhibited (THIK) subfamily, bearing 46% identity to THIK-1 (KCNK 13) and 48% to THIK-2 (KCNK12).	Halothane	91-100	potassium two pore domain channel subfamily K member 12	Homo sapiens	189-195
15175324-2	2004	When coexpressed with the m(2) acetylcholine (ACh) receptor in Xenopus oocytes, agonist-activated GIRK1(F137S)- and GIRK2-mediated currents are inhibited by halothane, whereas in the absence of ACh, high concentrations of halothane induce GIRK1(F137S)-mediated currents.	Halothane	157-166	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	98-103
15175324-2	2004	When coexpressed with the m(2) acetylcholine (ACh) receptor in Xenopus oocytes, agonist-activated GIRK1(F137S)- and GIRK2-mediated currents are inhibited by halothane, whereas in the absence of ACh, high concentrations of halothane induce GIRK1(F137S)-mediated currents.	Halothane	157-166	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	239-244
15175324-2	2004	When coexpressed with the m(2) acetylcholine (ACh) receptor in Xenopus oocytes, agonist-activated GIRK1(F137S)- and GIRK2-mediated currents are inhibited by halothane, whereas in the absence of ACh, high concentrations of halothane induce GIRK1(F137S)-mediated currents.	Halothane	222-231	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	98-103
15175324-3	2004	To elucidate the molecular mechanism of halothane action on GIRK currents of different subunit compositions, we constructed deletion mutants of GIRK1(F137S) (GIRK1(Delta363*)) and GIRK2 (GIRK2(Delta356)) lacking the C-terminal ends, as well as chimeric GIRK channels.	Halothane	40-49	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	60-64
15175324-3	2004	To elucidate the molecular mechanism of halothane action on GIRK currents of different subunit compositions, we constructed deletion mutants of GIRK1(F137S) (GIRK1(Delta363*)) and GIRK2 (GIRK2(Delta356)) lacking the C-terminal ends, as well as chimeric GIRK channels.	Halothane	40-49	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	144-149
15175324-4	2004	Mutated GIRK channels showed normal currents when activated by ACh but exhibited different pharmacological properties toward halothane.	Halothane	125-134	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	8-12
15175324-6	2004	GIRK1(Delta363*) was activated by halothane more efficiently.	Halothane	34-43	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	0-5
15175324-9	2004	Single channel experiments revealed an influence of halothane on the gating of the channels: The agonist-induced currents of GIRK1 and GIRK2, carried mainly by brief openings, were inhibited, whereas higher concentrations of the anesthetic promoted long openings of GIRK1 channels.	Halothane	52-61	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	125-130
15175324-9	2004	Single channel experiments revealed an influence of halothane on the gating of the channels: The agonist-induced currents of GIRK1 and GIRK2, carried mainly by brief openings, were inhibited, whereas higher concentrations of the anesthetic promoted long openings of GIRK1 channels.	Halothane	52-61	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	266-271
15277919-9	2004	The halothane concentrations needed to immobilize 50% of N2 or gas-1 animals, respectively, did not reduce oxidative phosphorylation to identical rates in the two strains.	Halothane	4-13	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	63-68
15277919-10	2004	In air, adenosine triphosphate concentrations were similar for N2 and gas-1 but were decreased in the presence of halothane only in gas-1 animals.	Halothane	114-123	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	132-137
15339022-6	2004	Therefore, a study was conducted to determine the effectiveness of screening broilers with halothane to identify those prone to developing PSE meat.	Halothane	91-100	PSE	Sus scrofa	139-142
15281508-3	2004	To test the importance of PKC for the immobility produced by inhaled anesthetics, we measured the effect of intrathecal injections of PKC-epsilon and -gamma inhibitors on halothane minimum alveolar anesthetic concentration (MAC) in 7-day-old and 21-day-old Sprague-Dawley rats.	Halothane	171-180	protein kinase C, gamma	Rattus norvegicus	134-156
12962913-0	2003	Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel.	Halothane	25-34	carbonic anhydrase 2	Mus musculus	100-103
15220780-7	2004	CONCLUSIONS: Halothane and hexanol interact with the receptor-heterotrimeric G-protein complex in a manner that prevents acetylcholine-promoted exchange of guanosine-5(")-triphosphate for guanosine-5"-diphosphate at Galphaq/11.	Halothane	13-22	G protein subunit alpha q	Homo sapiens	216-223
14759223-1	2004	Propofol and halothane are clinically used general anaesthetics, which are transported primarily by HSA (human serum albumin) in the blood.	Halothane	13-22	albumin	Homo sapiens	111-124
15290420-7	2004	Halothane or isoflurane augmented the LPS- and TNF-induced activation of p38 MAPK.	Halothane	0-9	tumor necrosis factor	Homo sapiens	47-50
15290420-7	2004	Halothane or isoflurane augmented the LPS- and TNF-induced activation of p38 MAPK.	Halothane	0-9	mitogen-activated protein kinase 14	Homo sapiens	73-76
12959958-1	2004	Mutations in the skeletal muscle RyR1 isoform of the ryanodine receptor (RyR) Ca2+-release channel confer susceptibility to malignant hyperthermia, which may be triggered by inhalational anesthetics such as halothane.	Halothane	207-216	ryanodine receptor 1	Homo sapiens	33-37
12959958-5	2004	In the concentration range of 0.014-0.35 mM halothane, anesthetic-induced oligomerization of the RyR1 complex was observed at a lower threshold concentration in the sarcoplasmic reticulum from patients with malignant hyperthermia.	Halothane	44-53	ryanodine receptor 1	Homo sapiens	97-101
14621991-0	2003	Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane.	Halothane	103-112	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	18-50
14621991-1	2003	To identify inhalational anesthetic binding domains in a ligand-gated ion channel, we photolabeled nicotinic acetylcholine receptor (nAChR)-rich membranes from Torpedo electric organ with [(14)C]halothane and determined by Edman degradation some of the photolabeled amino acids in nAChR subunit fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and high-performance liquid chromatography.	Halothane	195-204	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	99-131
14621991-9	2003	Halothane photolabeling of deltaTyr-228 provides initial evidence that halothane and isoflurane bind within this pocket with occupancy or access increased in the nAChR desensitized state compared to the closed channel state.	Halothane	0-9	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	162-167
14621991-9	2003	Halothane photolabeling of deltaTyr-228 provides initial evidence that halothane and isoflurane bind within this pocket with occupancy or access increased in the nAChR desensitized state compared to the closed channel state.	Halothane	71-80	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	162-167
22063689-4	2003	The presence of the Hal gene in this line resulted in meat of poorer quality in terms of meat of higher exudate compared to line D, also a well conformed line of predominantly Pietrain origin but being halothane gene free.	Halothane	202-211	histidine ammonia-lyase	Sus scrofa	20-23
15220780-2	2004	This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of the Gq/11 heterotrimeric G protein (Galphaq/11; i.e., they inhibit muscarinic receptor-Galphaq/11 coupling).	Halothane	54-63	G protein subunit alpha q	Homo sapiens	236-243
15220780-2	2004	This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of the Gq/11 heterotrimeric G protein (Galphaq/11; i.e., they inhibit muscarinic receptor-Galphaq/11 coupling).	Halothane	54-63	G protein subunit alpha q	Homo sapiens	287-294
15220780-3	2004	METHODS: The effect of halothane (0.38 +/- 0.02 mm) and hexanol (10 mm) on basal and acetylcholine-stimulated Galphaq/11 guanosine nucleotide exchange was determined in membranes prepared from porcine tracheal smooth muscle.	Halothane	23-32	G protein subunit alpha q	Homo sapiens	110-117
15220780-6	2004	Whereas neither anesthetic had an effect on basal Galphaq/11 nucleotide exchange, both halothane and hexanol significantly inhibited the increase in Galphaq/11 nucleotide exchange produced by 30 microm acetylcholine (by 59% and 68%, respectively).	Halothane	87-96	G protein subunit alpha q	Homo sapiens	149-156
15341219-0	2004	Expression of the c-fos gene in spinal cord and brain cells in rats subjected to stress in conditions of exposure to various types of halothane anesthesia.	Halothane	134-143	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
15341219-2	2004	Synthesis of c-Fos-like proteins occurred only in the spinal cord in conditions of constant 1.5% halothane anesthesia.	Halothane	97-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
15341219-3	2004	Use of induction anesthesia with 1.5% halothane allowed detection of c-Fos-like protein expression in cells of the rat spinal cord (lumbar segments) and brain, both when animals were placed in a hammock and when mechanical pain stimulation or electromagnetic irradiation of the skin with UHF currents were applied.	Halothane	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
15269663-17	2004	Functional studies of the RYR1 mutations have shown that MHS mutations were mainly associated with an alteration of the calcium fluxes in response to caffeine or halothane while CCD mutations would result in a leaky RYR1 channel or would alter the Excitation-Contraction coupling at the level of the CMC.	Halothane	162-171	ryanodine receptor 1	Homo sapiens	26-30
14689487-9	2004	Anesthesia with halothane induced the strongest c-Fos expression in a restricted pool of pmXII located in the pons at the level of the Kolliker-Fuse nucleus and the intertrigeminal region.	Halothane	16-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
15290420-0	2004	The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation.	Halothane	25-34	mitogen-activated protein kinase 14	Homo sapiens	107-110
15290420-2	2004	Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critical role in the cellular responses to extracellular stimuli such as lipopolysaccharide (LPS) and proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 (IL-1).	Halothane	134-143	mitogen-activated protein kinase 14	Homo sapiens	180-216
14986543-4	2003	In our study, we analyze 8 cases of halothane-induced hepatitis, notified in the Centre National de Pharmacovigilance between 1994 and 1999 and validate according to B.	Halothane	36-45	transducer of ERBB2, 1	Homo sapiens	163-167
12962913-5	2003	Halothane also depressed field excitatory postsynaptic potentials recorded from the Schaffer collateral-CA1 hippocampal synapses more greatly in the knockout mice.	Halothane	0-9	carbonic anhydrase 1	Mus musculus	104-107
12962913-8	2003	We suggest that inhibition of the N-type Ca2+ channel underlies mechanisms of halothane anesthesia but counteracts propofol anesthesia.	Halothane	78-87	carbonic anhydrase 2	Mus musculus	41-44
14641996-6	2003	In myotubes of individuals carrying the RyR1 Ile2182Phe or the RyR1 Gly2375Ala mutation, the EC(50) for caffeine and halothane was reduced; in the Ile2182Phe myotubes, the EC(50) for 4CmC was also reduced, all consistent with facilitated calcium release from the sarcoplasmic reticulum.	Halothane	117-126	ryanodine receptor 1	Homo sapiens	40-44
14641996-6	2003	In myotubes of individuals carrying the RyR1 Ile2182Phe or the RyR1 Gly2375Ala mutation, the EC(50) for caffeine and halothane was reduced; in the Ile2182Phe myotubes, the EC(50) for 4CmC was also reduced, all consistent with facilitated calcium release from the sarcoplasmic reticulum.	Halothane	117-126	ryanodine receptor 1	Homo sapiens	63-67