PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2558645-1	1989	Hypochlorous acid generated by myeloperoxidase reacts with histamine to produce chloramines.	Chloramines	80-91	myeloperoxidase	Cavia porcellus	31-46
2515607-1	1989	Oxidation of fibrinogen degradation products (FDP) with chloramines, results in a five- fold increase of their property to stimulate plasminogen activation by tissue type plasminogen activator (t-PA).	Chloramines	56-67	plasminogen activator, tissue type	Homo sapiens	159-192
2515607-1	1989	Oxidation of fibrinogen degradation products (FDP) with chloramines, results in a five- fold increase of their property to stimulate plasminogen activation by tissue type plasminogen activator (t-PA).	Chloramines	56-67	plasminogen activator, tissue type	Homo sapiens	194-198
3015901-4	1986	Under conditions similar to those in plasma (0.14 M Cl-, 0.02-0.12 mM SCN-), myeloperoxidase catalyzed the oxidation of Cl- to hypochlorous acid (HOCl), which reacted with ammonia and amines to yield chloramines.	Chloramines	200-211	myeloperoxidase	Homo sapiens	77-92
7144671-0	1982	Heinz-body haemolysis in haemodialysed patients caused by chloramines in Sydney tap water.	Chloramines	58-69	nuclear RNA export factor 1	Homo sapiens	80-83
2825313-4	1986	The primary granules of neutrophils contain the enzyme myeloperoxidase, which combines with H2O2 and ultimately leads to production of many toxic oxidant species: Halogens, hypochlorous acid, chloramines, aldehydes, and singlet oxygen.	Chloramines	192-203	myeloperoxidase	Homo sapiens	55-70
6095920-5	1984	Taurine, which in the presence of myeloperoxidase-H2O2-Cl forms hydrophilic chloramines, and D-penicillamine, which scavenges HOCl, neutralize the inhibitory effect of myeloperoxidase.	Chloramines	76-87	myeloperoxidase	Homo sapiens	34-49
29498521-0	2018	Theoretical Investigation of the Gas-Phase SN2 Reactions of Anionic and Neutral Nucleophiles with Chloramines.	Chloramines	98-109	solute carrier family 38 member 5	Homo sapiens	43-46
600956-1	1977	In two dialysis centres in the same city, with a total of 56 patients on regular dialysis treatment, it has been shown that the tap water used for the production of the dialysate contains chloramines.	Chloramines	188-199	nuclear RNA export factor 1	Homo sapiens	128-131
30889356-8	2019	The level of 1,4-dioxane degradation was ~30-50% lower for the UV/chloramine AOP than for the UV/H2O2-chloramine AOP when the concentration of residual chloramines in RO permeate was ~50 muM (3.3 mg/L as Cl2).	Chloramines	152-163	endogenous retrovirus group W member 5	Homo sapiens	204-207
30312794-2	2018	UV treatment is used widely to remove chloramines, which are the most prevalent group of DBPs, albeit chloro-organic DBP concentrations often increase during post-UV chlorination.	Chloramines	38-49	D-box binding PAR bZIP transcription factor	Homo sapiens	89-92
30540262-6	2018	The concentration of total chloramines (650 +- 490 mug L-1) was well above the WHO guidelines in all reported cases.	Chloramines	27-38	immunoglobulin kappa variable 1-16	Homo sapiens	55-58
29496995-5	2018	Moreover, we present two further pathways of carbamylation that involve reaction products of MPO, namely oxidation of cyanide by hypochlorous acid and reaction of thiocyanate with chloramines.	Chloramines	180-191	myeloperoxidase	Homo sapiens	93-96
29496995-7	2018	In summary, our findings indicate that cyanide is a substrate for MPO and suggest an additional pathway for in vivo cyanate formation and protein carbamylation that involves MPO either directly or via its reaction products hypochlorous acid or chloramines.	Chloramines	244-255	myeloperoxidase	Homo sapiens	174-177
699406-1	1978	Chloramines, compounds made up of chlorine and ammonia, when present in tap water used for dialysis cause methemoglobinemia and hemolysis.	Chloramines	0-11	nuclear RNA export factor 1	Homo sapiens	72-75
699406-9	1978	We conclude that addition of ascorbic acid to neutralize chloramines in tap water is also effective when using the proportioning dialysis delivery system.	Chloramines	57-68	nuclear RNA export factor 1	Homo sapiens	72-75
4378090-0	1971	Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase.	Chloramines	0-11	myeloperoxidase	Homo sapiens	69-84
33657673-8	2021	Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid, and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl.	Chloramines	0-11	microtubule associated protein tau	Homo sapiens	200-203
29605448-5	2018	Subsequent activation of myeloperoxidase (MPO) generates secondary oxidants and chloroamines that are highly microbiocidal in nature, which together with proteases such as elastase and gelatinase provide a toxic intra-phagosomal environment able to kill a broad range of micro-organisms.	Chloramines	80-92	myeloperoxidase	Homo sapiens	25-40
29605448-5	2018	Subsequent activation of myeloperoxidase (MPO) generates secondary oxidants and chloroamines that are highly microbiocidal in nature, which together with proteases such as elastase and gelatinase provide a toxic intra-phagosomal environment able to kill a broad range of micro-organisms.	Chloramines	80-92	myeloperoxidase	Homo sapiens	42-45
29498521-6	2018	The overall activation free energies (Delta G ) of the inversion channel for the SN2 reactions of F- and Cl- with chloramines are negative, whereas those for amines as nucleophiles are around 30-44 kcal/mol.	Chloramines	114-125	solute carrier family 38 member 5	Homo sapiens	81-84
28618281-10	2017	The results also indicated that although chloramines were much less reactive than chlorine toward iopamidol, they led to the formation of much more toxic iodinated DBPs, especially CHI3.	Chloramines	41-52	chitinase 1	Homo sapiens	181-185
28774620-4	2017	In this study we compared the induction of chronic cytotoxicity in mammalian cells in samples of municipal secondary wastewater effluent amended with elevated levels of Br-/I- after disinfection by chlorine, chloramines or ozone to identify which disinfection process generated wastewater with the lowest level of adverse biological response.	Chloramines	208-219	integral membrane protein 2B	Homo sapiens	169-175
23555742-8	2013	Compared to chlorine, chloramines resulted in higher concentration of iodinated DBP, but reduced the levels of trihalomethanes.	Chloramines	22-33	D-box binding PAR bZIP transcription factor	Homo sapiens	80-83
26057938-11	2015	These data demonstrate a novel and physiologically relevant mechanism whereby UCB could inhibit protein and lipid modification by quenching chloramines induced by MPO-induced HOCl.	Chloramines	140-151	myeloperoxidase	Rattus norvegicus	163-166
25517874-4	2014	Instead, treatment with HOCl or chloramines decreases the amino group content of RidA by reversibly N-chlorinating positively charged residues.	Chloramines	32-43	reactive intermediate imine deaminase A homolog	Homo sapiens	81-85
27262122-6	2016	Application of chloramines upstream of microfiltration for biofouling control increased DBP concentrations to their highest levels observed along the treatment trains.	Chloramines	15-26	D-box binding PAR bZIP transcription factor	Homo sapiens	88-91
22874433-9	2012	Glyceraldehyde-3-phosphate dehydrogenase, peroxiredoxins and cofilin were also highly sensitive to HOCl/chloramines.	Chloramines	104-115	cofilin 1	Homo sapiens	61-68
22990947-21	2013	In addition, chloramines produce lower DBP levels than does chlorine, although microbial activity in the distribution system may produce nitrate from monochloramine, when it is used as a residual disinfectant, Achieving the required levels of water quality, particularly microbial inactivation levels, while minimizing DBP formation requires the application of proper risk and disinfection management protocols.	Chloramines	13-24	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
22776434-3	2012	HOCl the product of the activated MPO/H(2)O(2)/Cl(-) system is known to react with the NH(2)-group of free amino acids to form chloramines which could exert some protective effect against protein modification and cytotoxicity induced by HOCl.	Chloramines	127-138	myeloperoxidase	Homo sapiens	34-37
22229717-4	2012	The peroxiredoxins (Prxs) are thiol proteins that have high reactivity with H(2)O(2) and may also be sensitive to HOCl and chloramines.	Chloramines	123-134	peroxiredoxin 1	Homo sapiens	4-18
22229717-5	2012	RESULTS: We have investigated human umbilical vein endothelial cells and shown that their cytoplasmic (Prx1 and Prx2) and mitochondrial (Prx3) Prxs are oxidized when they are exposed to H(2)O(2), HOCl, or cell-permeable chloramines.	Chloramines	220-231	peroxiredoxin 1	Homo sapiens	103-107
21988223-0	2011	Comprehensive theoretical studies on the gas phase SN2 reactions of anionic nucleophiles toward chloroamine and N-chlorodimethylamine with inversion and retention mechanisms.	Chloramines	96-107	solute carrier family 38 member 5	Homo sapiens	51-54
22773562-3	2012	Chloramines of proline, arginine, and glycine caused significant damage to PCNA in cells.	Chloramines	0-11	proliferating cell nuclear antigen	Homo sapiens	75-79
22773562-4	2012	Chloramines of taurine and histidine caused slight damage to PCNA in cells.	Chloramines	0-11	proliferating cell nuclear antigen	Homo sapiens	61-65
22425148-7	2012	UV exposure resulted in loss of inorganic chloramines (e.g., NCl(3)) from solution.	Chloramines	42-53	calpain 5	Homo sapiens	61-67
18296711-6	2008	Reduction of HDL-associated chloramines with methionine strongly impaired binding affinity of MPO towards HOCl-HDL.	Chloramines	28-39	myeloperoxidase	Homo sapiens	94-97
21654020-1	2011	The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath.	Chloramines	30-41	nucleolin	Homo sapiens	47-50
20106988-7	2010	We concluded that HOCl and its reactive intermediates (such as organic chloramines) inhibit ENaC by affecting channel gating, which could be relieved by proteases cleavage.	Chloramines	71-82	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	92-96
20158207-8	2010	The results indicate that organic chloramines are one type of DBPs in TOX that could be reduced by AC.	Chloramines	34-45	thymocyte selection associated high mobility group box	Homo sapiens	70-73
19716412-0	2009	Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2.	Chloramines	0-11	peroxiredoxin 2	Homo sapiens	54-69
19716412-10	2009	Our results show that, although HOCl and chloramines are less selective than H(2)O(2), they nevertheless oxidize Prx2.	Chloramines	41-52	peroxiredoxin 2	Homo sapiens	113-117
17911188-11	2007	Chloramines are important physiologic generators of nonradical excited singlet oxygen and enhance u-PA-mediated lysis of plasma clots.	Chloramines	0-11	plasminogen activator, urokinase	Homo sapiens	98-102
17558780-4	2007	In this pH range, the reactions of As(III) with chloroamine (NH2Cl) and H2O2 are quite slow with rate constants of 2.9-4.3x10(-1) M-1 s-1 and 2.6x10(-2)-4.5x10(1) M-1 s-1 for chloroamine and H2O2, respectively.	Chloramines	48-59	myoregulin	Homo sapiens	130-143
17969688-9	2007	The analysis by MIMS clearly indicates that volatile DBP formation in swimming pools is not limited to inorganic chloramines and haloforms.	Chloramines	113-124	D-box binding PAR bZIP transcription factor	Homo sapiens	53-56
16405428-0	2006	IkappaB is a sensitive target for oxidation by cell-permeable chloramines: inhibition of NF-kappaB activity by glycine chloramine through methionine oxidation.	Chloramines	62-73	nuclear factor kappa B subunit 1	Homo sapiens	89-98
17649724-3	2007	GM-CSF was labeled with 131I by the chloramines-T method.	Chloramines	36-47	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
17180964-9	2006	Although the use of alternative disinfectants (ozone, chlorine dioxide, and chloramines) minimized the formation of the four regulated THMs, trihalogenated HAAs, and total organic halogen (TOX), several priority DBPs were formed at higher levels with the alternative disinfectants as compared with chlorine.	Chloramines	76-87	thymocyte selection associated high mobility group box	Homo sapiens	189-192
17226929-0	2007	Kinetics and mechanism of the oxidation of the glutathione dimer by hypochlorous Acid and catalytic reduction of the chloroamine product by glutathione reductase.	Chloramines	117-128	glutathione-disulfide reductase	Homo sapiens	140-161
16405428-12	2006	These results show that cell-permeable chloramines, either directly or when formed in medium, could regulate NF-kappaB activation via reversible IkappaBalpha oxidation.	Chloramines	39-50	nuclear factor kappa B subunit 1	Homo sapiens	109-118
16405428-1	2006	Hypochlorous acid (HOCl) is produced by the neutrophil enzyme, myeloperoxidase, and reacts with amines to generate chloramines.	Chloramines	115-126	myeloperoxidase	Homo sapiens	63-78
16405428-12	2006	These results show that cell-permeable chloramines, either directly or when formed in medium, could regulate NF-kappaB activation via reversible IkappaBalpha oxidation.	Chloramines	39-50	NFKB inhibitor alpha	Homo sapiens	145-157
15693173-8	2005	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in cells was measured as an indicator of permeability of the chloramines.	Chloramines	119-130	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
16337878-1	2006	Hypochlorous acid (HOCl) and chloramines are produced by the neutrophil enzyme, myeloperoxidase.	Chloramines	29-40	myeloperoxidase	Homo sapiens	80-95
15689384-6	2005	The initial product of the MPO-H2O2-chloride system is hypochlorous acid, and subsequent formation of chlorine, chloramines, hydroxyl radicals, singlet oxygen, and ozone has been proposed.	Chloramines	112-123	myeloperoxidase	Homo sapiens	27-30
16599124-2	2006	This disinfection process may take the advantage of free chlorine"s quick inactivation of microorganism and chloramines" low DBP yield and long-term residual.	Chloramines	108-119	D-box binding PAR bZIP transcription factor	Homo sapiens	125-128
15693173-8	2005	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in cells was measured as an indicator of permeability of the chloramines.	Chloramines	119-130	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
15644245-6	2005	Methylamine forms stable chloramines, which might be determined as mono- and/or di-chloramine fractions together with free chlorine by the DPD method in the reaction mixtures at higher molar ratios of chlorine.	Chloramines	25-36	dihydropyrimidine dehydrogenase	Homo sapiens	139-142
11297432-7	2001	The covalent complex of radiolabeled dT(40) and SSB was also generated by chloramines and the complete myeloperoxidase-hydrogen peroxide-chloride system.	Chloramines	74-85	replication protein A1	Homo sapiens	48-51
15477013-8	2004	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in cells was measured as an indicator of permeability of the chloramines.	Chloramines	119-130	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
15477013-8	2004	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in cells was measured as an indicator of permeability of the chloramines.	Chloramines	119-130	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
12046046-4	2002	Methemoglobin levels normalized when the carbon filtration system of the portable dialysis machine was replaced with a larger unit to remove chloramines more effectively.	Chloramines	141-152	hemoglobin subunit gamma 2	Homo sapiens	0-13
12054473-7	2002	We conclude that the signal for apoptosis induced by H(2)O(2) in the MPO-containing HL-60 cell involves the reaction of the diffusible oxidant HOCl with amines producing chloramines and a subsequent non-TNB-reactive product.	Chloramines	170-181	myeloperoxidase	Homo sapiens	69-72
15663478-5	2005	Myeloperoxidase produces a powerful oxidant, hypochlorous acid that reacts with amines to form chloramines.	Chloramines	95-106	myeloperoxidase	Homo sapiens	0-15
11297432-10	2001	These results indicate that long-lived chloramines and HOCl generated by myeloperoxidase can generate covalent DNA-protein cross-links that may contribute to the mutagenic and cytotoxic effects of phagocytes on microbial pathogens and host tissue.	Chloramines	39-50	myeloperoxidase	Homo sapiens	73-88
10677371-6	2000	Further, we found that HOCl (25-200 microM)-dependent formation of chloramines on apolipoprotein B-100 was fully reversed by 200 microM vitamin C; however, the loss of lysine residues and increase in relative electrophoretic mobility of LDL were only partially reversed, and the loss of tryptophan and cysteine residues was not reversed.	Chloramines	67-78	apolipoprotein B	Homo sapiens	82-102
11440179-2	2001	In this study chlorination of N-acTyr residue at positions 3 and 5 in reactions with NaOCl, chloramines and the myeloperoxidase (MPO)-H2O2-Cl- chlorinating system were invesigated.	Chloramines	92-103	myeloperoxidase	Homo sapiens	129-132
10894808-3	2000	Myeloperoxidase generates a number of reactive species, including hypochlorous acid, chloramines, tyrosyl radicals, and nitrogen dioxide.	Chloramines	85-96	myeloperoxidase	Homo sapiens	0-15
10984130-7	2000	It was concluded that hypochlorous acid not only reacts with monochlorodimedone but also with the amino groups of myeloperoxidase to form intermediary chloramines that may further chlorinate monochlorodimedone.	Chloramines	151-162	myeloperoxidase	Homo sapiens	114-129
9425735-3	1997	Here, Janusz Marcinkiewicz examines recent data indicating that chloramines, the neutrophil-specific products of the myeloperoxidase--hydrogen-peroxide--halide system, may provide a bridge between the afferent branches of the innate and acquired immune response.	Chloramines	64-75	myeloperoxidase	Homo sapiens	117-132
10994873-7	2000	Uptake was promoted by adding MPO and blocked by the MPO inhibitor dapsone, catalase, scavengers for hypochlorous acid and chloramines, or in a low-chloride medium, but not by histamine receptor antagonists.	Chloramines	123-134	myeloperoxidase	Homo sapiens	30-33
10994873-7	2000	Uptake was promoted by adding MPO and blocked by the MPO inhibitor dapsone, catalase, scavengers for hypochlorous acid and chloramines, or in a low-chloride medium, but not by histamine receptor antagonists.	Chloramines	123-134	myeloperoxidase	Homo sapiens	53-56
10215584-0	1999	Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins.	Chloramines	32-43	apolipoprotein B	Homo sapiens	47-67
7506191-3	1993	Among the oxidants released are potent chlorinated compounds, such as hypochlorous acid and chloramines, which induce tissue cell damage and inactivate protease inhibitors, particularly alpha 1-antitrypsin, the specific inhibitor of neutrophil elastase.	Chloramines	92-103	serpin family A member 1	Homo sapiens	186-205
10723309-0	1996	Use of erythropoietin in emergencies: massive intoxication by chloramines.	Chloramines	62-73	erythropoietin	Homo sapiens	7-21
8877407-5	1996	Stimulated PMN release H2O2 and MPO that produces hypochlorite and secondarily various chloramines.	Chloramines	87-98	myeloperoxidase	Homo sapiens	32-35
8877407-10	1996	Azide, an inhibitor of myeloperoxidase, and catalase which destroys H2O2, essential for MPO-catalyzed oxidations, prevented the generation of C5 activating potency and of chloramines.	Chloramines	171-182	myeloperoxidase	Homo sapiens	88-91
8529024-5	1995	Suppression of myeloperoxidase reaction by carnosine and related compounds is explained by both inhibiting action on the enzyme itself, and direct neutralization of hypochlorous anion due to formation of stable chloroamine complexes.	Chloramines	211-222	myeloperoxidase	Oryctolagus cuniculus	15-30
7852368-7	1995	In the presence of physiologic levels of both bromide (0.1 mM) and chloride (0.1 M), myeloperoxidase and eosinophil peroxidase produced mixtures of bromamines and chloramines containing 6 +/- 4% and 88 +/- 4% bromamine.	Chloramines	163-174	myeloperoxidase	Homo sapiens	85-100
7852368-7	1995	In the presence of physiologic levels of both bromide (0.1 mM) and chloride (0.1 M), myeloperoxidase and eosinophil peroxidase produced mixtures of bromamines and chloramines containing 6 +/- 4% and 88 +/- 4% bromamine.	Chloramines	163-174	eosinophil peroxidase	Homo sapiens	105-126
1846732-8	1991	The reaction between HOCl and fibronectin resulted in the formation of long-lived chloramines.	Chloramines	82-93	fibronectin 1	Homo sapiens	30-41
8380814-7	1993	These results suggest that aminoglycosides protect lung epithelial cells against myeloperoxidase-dependent oxidant injury by binding to anionic cell surfaces and converting HOCl to hydrophilic noncytotoxic chloramines, whereas penicillins and cephalosporins are potent HOCl scavengers capable of protecting critical extracellular molecules against oxidation.	Chloramines	206-217	myeloperoxidase	Homo sapiens	81-96