PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30146703-7	2019	Pretreatment of cells with metformin (40 microM) with or without AMPK inhibitor (dorsomorphin hydrochloride; 1 microM) before adding of morphine (2.5 microM) or methadone (1 microM) revealed a protective effects on the development of opioid tolerance.	dorsomorphin hydrochloride	81-107	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	65-69