PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16836976-4	2006	In marked contrast, pretreatment with tyrosine kinase inhibitor tyrphostin A25 (20 microM) strongly attenuated both the hyposmotic stimulation of I(Ks) in myocytes and the hyposmotic stimulation of current in BHK cells co-expressing Ks channel subunits KCNQ1 and KCNE1.	tyrphostin 25	64-78	potassium voltage-gated channel subfamily KQT member 1	Mesocricetus auratus	253-258
16836976-4	2006	In marked contrast, pretreatment with tyrosine kinase inhibitor tyrphostin A25 (20 microM) strongly attenuated both the hyposmotic stimulation of I(Ks) in myocytes and the hyposmotic stimulation of current in BHK cells co-expressing Ks channel subunits KCNQ1 and KCNE1.	tyrphostin 25	64-78	potassium voltage-gated channel subfamily E member 1	Mesocricetus auratus	263-268
12606946-6	2003	Treatment of cells with anti-TGFalpha or anti-EGFR antibody, or with tyrphostin-25 (EGFR inhibitor), significantly impaired the cell migration response to OPN.	tyrphostin 25	69-82	secreted phosphoprotein 1	Homo sapiens	155-158
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	tyrphostin 25	183-197	galectin 3	Homo sapiens	12-22
15209521-5	2004	Tyrphostin A25 (AG82) was the most potent inhibitor with an IC(50) of approximately 15 microM.	tyrphostin 25	16-20	immunoglobulin kappa variable 1-22 (pseudogene)	Homo sapiens	11-14
10712243-8	2000	Effects of tyrphostin A25, wortmannin, okadaic acid, or bisindolylmaleimide I in pipette solutions suggested that the insulin-induced increase in I(p) involved activation of tyrosine kinase, phosphatidylinositol 3-kinase, and protein phosphatase 1, whereas protein phosphatase 2A and protein kinase C were not involved.	tyrphostin 25	11-25	insulin	Oryctolagus cuniculus	118-125
14643763-4	2003	Activation of PI3K by IL-2 was also blocked by tyrphostin A25, a selective inhibitor of PTK, suggesting activation of the latter by IL-2 is upstream to PI3K activation.	tyrphostin 25	47-61	interleukin 2	Mus musculus	22-26
14643763-4	2003	Activation of PI3K by IL-2 was also blocked by tyrphostin A25, a selective inhibitor of PTK, suggesting activation of the latter by IL-2 is upstream to PI3K activation.	tyrphostin 25	47-61	interleukin 2	Mus musculus	132-136
11499571-6	2001	Tyrphostin A25, an inhibitor of phosphotyrosine kinases, ameliorated the IFNalpha induced decrease of TER.	tyrphostin 25	0-14	interferon-alpha-14	Sus scrofa	73-81
12606946-6	2003	Treatment of cells with anti-TGFalpha or anti-EGFR antibody, or with tyrphostin-25 (EGFR inhibitor), significantly impaired the cell migration response to OPN.	tyrphostin 25	69-82	epidermal growth factor receptor	Homo sapiens	84-88
10912998-8	2000	Pretreatment with tyrphostin-25, a protein tyrosine kinase (PTK) inhibitor, attenuated the BBS-mediated induction of c-jun and jun-B, but the effect was not as pronounced as with H-7.	tyrphostin 25	18-31	gastrin releasing peptide	Homo sapiens	91-94
10912998-8	2000	Pretreatment with tyrphostin-25, a protein tyrosine kinase (PTK) inhibitor, attenuated the BBS-mediated induction of c-jun and jun-B, but the effect was not as pronounced as with H-7.	tyrphostin 25	18-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
10912998-8	2000	Pretreatment with tyrphostin-25, a protein tyrosine kinase (PTK) inhibitor, attenuated the BBS-mediated induction of c-jun and jun-B, but the effect was not as pronounced as with H-7.	tyrphostin 25	18-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
9786865-6	1998	The tyrosine kinase inhibitor tyrphostin A25 blocked the neurite retraction and cell rounding induced by Galpha13 and Galphaq.	tyrphostin 25	30-44	G protein subunit alpha 13	Rattus norvegicus	105-113
10666036-2	2000	Here we show that exposing cardiac myocytes to tyrosine kinase inhibitors (genistein, tyrphostin A25), but not inactive analogs, prevents downregulation of Kv1.5 mRNA and upregulation of Kv4.2 mRNA normally observed when they are cultured under low-density conditions.	tyrphostin 25	86-100	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	156-161
10666036-2	2000	Here we show that exposing cardiac myocytes to tyrosine kinase inhibitors (genistein, tyrphostin A25), but not inactive analogs, prevents downregulation of Kv1.5 mRNA and upregulation of Kv4.2 mRNA normally observed when they are cultured under low-density conditions.	tyrphostin 25	86-100	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	187-192
10712812-7	2000	Addition of tyrphostin A-25, an inhibitor of receptor tyrosine kinase, attenuated the tyrosine phosphorylation of PLCgamma1 as well as its enzyme activity.	tyrphostin 25	12-27	LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Oryctolagus cuniculus	114-123
10333476-3	1999	Tyrphostin A25, a tyrosine kinase inhibitor, blocked neurite retraction and cell rounding induced by activation of the EP3 receptor, however, it failed to block neurite retraction and cell rounding induced by microinjection of constitutively active RhoA, RhoAV14, indicating that a tyrphostin-sensitive tyrosine kinase was involved in the pathway from the EP3 receptor to Rho activation.	tyrphostin 25	0-14	prostaglandin E receptor 3	Rattus norvegicus	119-122
9786865-6	1998	The tyrosine kinase inhibitor tyrphostin A25 blocked the neurite retraction and cell rounding induced by Galpha13 and Galphaq.	tyrphostin 25	30-44	G protein subunit alpha q	Rattus norvegicus	118-125
9586964-3	1998	This inhibitory effect of bFGF on both amylase secretion and [Ca2+]i increase in response to CCK-8 was reverted when acinar cells were pretreated with 100 microM tyrphostin A25, a tyrosine kinase inhibitor.	tyrphostin 25	162-176	fibroblast growth factor 2	Rattus norvegicus	26-30
8978816-6	1996	A stimulatory peptide derived from the NH2 terminus of the small GTP-binding protein ADP ribosylation factor 1 (ARF1) antagonized the inhibitory effect of TA25, indicating that both agents influence the same pathway leading to secretory vesicle formation.	tyrphostin 25	155-159	ADP-ribosylation factor 1	Rattus norvegicus	85-110
9405068-11	1997	The tyrosine kinase inhibitor, tyrphostin A25, inhibited NMB-induced phosphorylation of p125(FAK) by 52%.	tyrphostin 25	31-45	neuromedin B	Rattus norvegicus	57-60
9405068-11	1997	The tyrosine kinase inhibitor, tyrphostin A25, inhibited NMB-induced phosphorylation of p125(FAK) by 52%.	tyrphostin 25	31-45	protein tyrosine kinase 2	Rattus norvegicus	93-96
9211886-8	1997	On the other hand, genistein, tyrphostin-25 (inhibitors of tyrosine-specific protein kinase), and calphostin C (an inhibitor of protein kinase C) block the activation of PAF:acyllyso-GPC transacetylase by ATP.	tyrphostin 25	30-43	PCNA-associated factor	Bos taurus	170-173
9211886-8	1997	On the other hand, genistein, tyrphostin-25 (inhibitors of tyrosine-specific protein kinase), and calphostin C (an inhibitor of protein kinase C) block the activation of PAF:acyllyso-GPC transacetylase by ATP.	tyrphostin 25	30-43	glycophorin C	Bos taurus	183-186
9106265-3	1997	This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS)-induced production of TNF alpha, IL-1 alpha, and IL-6 in mouse primary mixed glia, microglia- or astrocyte-enriched cultures.	tyrphostin 25	96-110	tumor necrosis factor	Mus musculus	162-171
9106265-3	1997	This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS)-induced production of TNF alpha, IL-1 alpha, and IL-6 in mouse primary mixed glia, microglia- or astrocyte-enriched cultures.	tyrphostin 25	96-110	interleukin 6	Mus musculus	189-193
12168008-5	1998	However, when both Tyrphostin-25 and sphingosine were added to the culture medium, the elevation of GnT-V caused by EGF or PMA was entirely blocked.	tyrphostin 25	19-32	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	100-105
12168008-5	1998	However, when both Tyrphostin-25 and sphingosine were added to the culture medium, the elevation of GnT-V caused by EGF or PMA was entirely blocked.	tyrphostin 25	19-32	epidermal growth factor	Homo sapiens	116-119
9469660-2	1997	Here, we report that the ACh-reducing effect of either Abeta 1-28 or Abeta 1-42 (100 nM; 48 h) in SN56 cells can be prevented by a co-treatment with the tyrosine kinase inhibitors, genistein (75 microM) and tyrphostin A25 (50 microM).	tyrphostin 25	207-221	amyloid beta (A4) precursor protein	Mus musculus	55-60
9469660-2	1997	Here, we report that the ACh-reducing effect of either Abeta 1-28 or Abeta 1-42 (100 nM; 48 h) in SN56 cells can be prevented by a co-treatment with the tyrosine kinase inhibitors, genistein (75 microM) and tyrphostin A25 (50 microM).	tyrphostin 25	207-221	amyloid beta (A4) precursor protein	Mus musculus	69-74
8978816-6	1996	A stimulatory peptide derived from the NH2 terminus of the small GTP-binding protein ADP ribosylation factor 1 (ARF1) antagonized the inhibitory effect of TA25, indicating that both agents influence the same pathway leading to secretory vesicle formation.	tyrphostin 25	155-159	ADP-ribosylation factor 1	Rattus norvegicus	112-116
7664693-4	1995	This FSH and IGF-I stimulated CytPTK activity was blocked by AG-82 (a tyrosine kinase inhibitor) and by staurosporine (STS) (a non specific protein kinase inhibitor) at concentrations which inhibited E2 production.	tyrphostin 25	61-66	insulin like growth factor 1	Homo sapiens	13-18
8895754-5	1996	Tyrphostin A25, which blocks activity of tyrosine kinases, significantly inhibited SP-induced mitogenesis, suggesting that the mitogenic response induced by SP peptide involves phosphorylation by tyrosine kinases.	tyrphostin 25	0-14	tachykinin precursor 1	Homo sapiens	83-85
8895754-5	1996	Tyrphostin A25, which blocks activity of tyrosine kinases, significantly inhibited SP-induced mitogenesis, suggesting that the mitogenic response induced by SP peptide involves phosphorylation by tyrosine kinases.	tyrphostin 25	0-14	tachykinin precursor 1	Homo sapiens	157-159
8891338-8	1996	Related isoflavones were less potent growth inhibitors than genistein, whereas the synthetic PTK inhibitor tyrphostin A25 was an equally potent growth inhibitor.	tyrphostin 25	107-121	protein tyrosine kinase 2 beta	Homo sapiens	93-96
8770005-5	1996	Tyrosine kinase inhibitor tyrphostin A25 (100 microM) inhibited not only the tyrosine phosphorylation of pp125FAK and paxillin but also the redistribution of pp125FAK and paxillin, morphological change, and migration of EC induced by strain.	tyrphostin 25	26-40	paxillin	Bos taurus	118-126
8770005-5	1996	Tyrosine kinase inhibitor tyrphostin A25 (100 microM) inhibited not only the tyrosine phosphorylation of pp125FAK and paxillin but also the redistribution of pp125FAK and paxillin, morphological change, and migration of EC induced by strain.	tyrphostin 25	26-40	paxillin	Bos taurus	171-179
8667246-6	1996	Tyrphostin-25 (100 microM), a selective inhibitor of PTKs, when given in vivo was also able to attenuate phosphorylation by AII, further suggesting a PTK-mediated event.	tyrphostin 25	0-13	angiotensinogen	Rattus norvegicus	124-127
8900457-4	1996	Both DGAT inactivating and kinase activities assayed from the purified sample have been found to be insensitive to the Ser/Thr kinase inhibitor H-7 while being sensitive to genistein and tyrphostin-25.	tyrphostin 25	187-200	diacylglycerol O-acyltransferase 1	Homo sapiens	5-9
8922039-7	1996	Gastrin activation of both Tyr-kinase and PLC was abolished by Tyr-kinase inhibitor, tyrphostin-25 (3.2 microM) and was not affected by staurosporine (20 ng/ml).	tyrphostin 25	85-98	gastrin	Rattus norvegicus	0-7
8632696-4	1996	Tyrphostin-25 inhibited AII, but not PE contractions and was less potent in the hypertensive arteries.	tyrphostin 25	0-13	angiotensinogen	Rattus norvegicus	24-27
7507517-4	1994	The presence of tyrphostin-25 (10 microM), which is highly specific for tyrosine kinases, also blocked iNOS induction.	tyrphostin 25	16-29	nitric oxide synthase 2	Rattus norvegicus	103-107
30343052-8	2019	The effects induced by adhesion substrates were inhibited by AG82 (Tyrphostin 25) and herbimycin A, indicating their dependence on the activation of both the EGF receptor and the tyrosine kinase c-src.	tyrphostin 25	61-65	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	195-200