PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29412511-10	2018	A diagnostic panel comprising lithocholic acid (LCA), tauro-LCA, glyco-LCA and hyocholic acid was identified that could differentiate the ABCB11-mutated cohort from healthy controls and undiagnosed cholestasis patients (AUC=0.946, p < 0.0001) and, in non-ABCB11-mutated cholestasis patients, could distinguish BSEP dysfunction from normal BSEP function (9/12 vs 0/38, p < 0.0000001).	muricholic acid	79-93	ATP binding cassette subfamily B member 11	Homo sapiens	138-144
30221552-6	2018	Molecular dynamics (MD) gave insights on the stability over time of hyocholic acid binding to CA II.	muricholic acid	68-82	carbonic anhydrase 2	Homo sapiens	94-99
29553998-9	2018	The recent identification of cytochrome P450 2C70 as key enzyme in the formation of rodent-specific hydrophilic muricholic acids allows for the development of adequate mouse models for this purpose.	muricholic acid	112-128	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	29-49
29058872-5	2017	We found that the most abundant bile acid in the mouse (beta-muricholic acid) binds with weak affinity individually and in combination with other bile acids.	muricholic acid	56-76	glucosidase beta 2	Mus musculus	32-41
29175670-4	2018	When compared to wild-type mice, muricholic acid (MCA) and chenodeoxycholic acid (CDCA) increased approximately 15-, 82-, 22- and 38-fold, respectively, in hepatic tissue of ApoE-deficient mice given a chow or HCHF diet.	muricholic acid	33-48	apolipoprotein E	Mus musculus	174-178
28892150-7	2017	In addition, WD-fed FXR KO male mice had the highest concentration of hepatic beta-muricholic acid (beta-MCA) and bacteria-generated deoxycholic acid (DCA) accompanied by serious hepatitis.	muricholic acid	78-98	nuclear receptor subfamily 1, group H, member 4	Mus musculus	20-23
28892150-7	2017	In addition, WD-fed FXR KO male mice had the highest concentration of hepatic beta-muricholic acid (beta-MCA) and bacteria-generated deoxycholic acid (DCA) accompanied by serious hepatitis.	muricholic acid	100-108	nuclear receptor subfamily 1, group H, member 4	Mus musculus	20-23
27789682-7	2017	When compared with normal human liver tissue, hFRGN livers showed lower SHP mRNA and higher CYP7A1 (300%) protein expression, consequences of tbeta- and talpha-muricholic acid-mediated inhibition of the FXR-SHP cascade and miscommunication between intestinal Fgf15 and human liver fibroblast growth factor receptor 4 (FGFR4), as confirmed by the unchanged hepatic pERK/total ERK ratio.	muricholic acid	160-175	nuclear receptor subfamily 1 group H member 4	Homo sapiens	203-206
28496104-5	2017	FXR deficiency enriched Desulfovibrionaceae, Deferribacteraceae, and Helicobacteraceae, which were accompanied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well as hepatic and serum lipids.	muricholic acid	167-187	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3
27634100-9	2016	Finally, the MRM-MS quantification of CYP3A4 in homogenates also correlated (r = 0.44; p < 0.05) with the level of enzyme activity in the same samples, as determined by measuring the chenodeoxycholic to hyocholic acid conversion.	muricholic acid	206-220	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44
25447797-3	2015	Here we demonstrate that in Cyp7a1(-/-) mice fed chenodeoxycholic acid (CDCA) at a level of 0.06% (w/w), the BAP was restored to normal size and became substantially enriched with muricholic acid (MCA) (>70%), leaving the combined contribution of CA and CDCA to be <15%.	muricholic acid	180-195	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	28-34
26670557-2	2015	Here we show that treatment of mice with glycine-beta-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity.	muricholic acid	49-69	nuclear receptor subfamily 1, group H, member 4	Mus musculus	89-92
27359351-5	2016	OCA markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and altered bile acid composition, with the alpha/beta-muricholic acid proportion in bile increased by 2.6-fold and taurocholic acid (TCA) level reduced by 71%.	muricholic acid	250-270	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	30-60
27359351-5	2016	OCA markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and altered bile acid composition, with the alpha/beta-muricholic acid proportion in bile increased by 2.6-fold and taurocholic acid (TCA) level reduced by 71%.	muricholic acid	250-270	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	62-68
27359351-5	2016	OCA markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and altered bile acid composition, with the alpha/beta-muricholic acid proportion in bile increased by 2.6-fold and taurocholic acid (TCA) level reduced by 71%.	muricholic acid	250-270	cytochrome P450, family 8, subfamily b, polypeptide 1	Mus musculus	102-108
25447797-3	2015	Here we demonstrate that in Cyp7a1(-/-) mice fed chenodeoxycholic acid (CDCA) at a level of 0.06% (w/w), the BAP was restored to normal size and became substantially enriched with muricholic acid (MCA) (>70%), leaving the combined contribution of CA and CDCA to be <15%.	muricholic acid	197-200	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	28-34
23756265-6	2013	UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G.	muricholic acid	75-78	UDP glucuronosyltransferase family 2 member A1 complex locus	Homo sapiens	0-6
23756265-6	2013	UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G.	muricholic acid	75-78	UDP glucuronosyltransferase family 2 member A2	Homo sapiens	105-111
23756265-6	2013	UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G.	muricholic acid	235-238	UDP glucuronosyltransferase family 2 member A1 complex locus	Homo sapiens	0-6
23756265-6	2013	UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G.	muricholic acid	235-238	UDP glucuronosyltransferase family 2 member A2	Homo sapiens	105-111
16606610-7	2006	In addition, ERalpha up-regulated the expression of CYP7B1 and down-regulated the CYP7A1 and CYP8B1, shifting bile acid synthesis toward the acidic pathway to increase the serum level of beta-muricholic acid.	muricholic acid	187-207	estrogen receptor 1 (alpha)	Mus musculus	13-20
22525741-5	2012	RESULTS: We detected 2 heterozygous mutations in the ATP8B1 gene, and increasing amounts of unusual bile acids such as 1beta-hydroxylated cholic acid, 2beta-hydroxylated cholic acid, 4beta-hydroxylated cholic acid, 6alpha-hydroxylated cholic acid, and hyocholic acid in urine during rifampicin treatment.	muricholic acid	252-266	ATPase phospholipid transporting 8B1	Homo sapiens	53-59
18583509-8	2008	Among the human recombinant P450 enzymes examined, CYP3A4 exhibited the highest rates of formation for 7alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid and gamma-muricholic acid from chenodeoxycholic acid.	muricholic acid	153-174	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57
18473750-10	2008	The enzyme catalyzing the 6alpha-hydroxylation in hyocholic acid biosynthesis in pig was found to be an atypical member of the CYP4A subfamily, denoted CYP4A21.	muricholic acid	50-64	cytochrome P450 family 4 subfamily A member 21	Sus scrofa	152-159
16606610-7	2006	In addition, ERalpha up-regulated the expression of CYP7B1 and down-regulated the CYP7A1 and CYP8B1, shifting bile acid synthesis toward the acidic pathway to increase the serum level of beta-muricholic acid.	muricholic acid	187-207	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	52-58
16628672-8	2006	High-performance liquid chromatography analysis on liver extracts revealed that taurine tetrahydroxy bile acid/beta-muricholic acid ratios were increased twofold in Mrp4-/- mice.	muricholic acid	111-131	prolactin family 2, subfamily c, member 5	Mus musculus	165-169
14643796-9	2003	Both CYP8B1 and the key enzyme in hyocholic acid formation, taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21), were found to be expressed in pig liver in a developmental-dependent but opposite fashion.	muricholic acid	34-48	cytochrome P450 family 8 subfamily B member 1	Sus scrofa	5-11
16225954-7	2006	Glucuronide conjugates of hyocholate and hyodeoxycholate are substrates of MRP3 in vitro and in livers that lack Mrp3, there is reduced sinusoidal secretion of hyodeoxycholate-glucuronide after perfusion with hyodeoxycholate.	muricholic acid	26-36	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	75-79
16225954-7	2006	Glucuronide conjugates of hyocholate and hyodeoxycholate are substrates of MRP3 in vitro and in livers that lack Mrp3, there is reduced sinusoidal secretion of hyodeoxycholate-glucuronide after perfusion with hyodeoxycholate.	muricholic acid	26-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	113-117
14641109-2	2004	CYP4A21 participates in the formation of hyocholic acid, a species-specific primary bile acid in the pig.	muricholic acid	41-55	cytochrome P450 family 4 subfamily A member 21	Sus scrofa	0-7
14643796-9	2003	Both CYP8B1 and the key enzyme in hyocholic acid formation, taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21), were found to be expressed in pig liver in a developmental-dependent but opposite fashion.	muricholic acid	34-48	cytochrome P450 family 4 subfamily A member 21	Sus scrofa	60-105
14643796-9	2003	Both CYP8B1 and the key enzyme in hyocholic acid formation, taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21), were found to be expressed in pig liver in a developmental-dependent but opposite fashion.	muricholic acid	34-48	cytochrome P450 family 4 subfamily A member 21	Sus scrofa	107-114
32863311-3	2020	We previously reported that pharmacological VDR activation enhances urinary bile acid excretion, particularly in mice fed chow supplemented with chenodeoxycholic acid (CDCA), which is metabolized to muricholic acid in mouse liver and is also converted to LCA by intestinal bacteria.	muricholic acid	199-214	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	44-47
12748061-9	2003	Gene expression of intestinal sterol efflux transporters Abcg5 and Abcg8 was upregulated by feeding cholic acid but not by hydrophilic beta-muricholic acid nor by hydrophobic deoxycholic acid.	muricholic acid	135-155	ATP binding cassette subfamily G member 5	Mus musculus	57-62
12748061-9	2003	Gene expression of intestinal sterol efflux transporters Abcg5 and Abcg8 was upregulated by feeding cholic acid but not by hydrophilic beta-muricholic acid nor by hydrophobic deoxycholic acid.	muricholic acid	135-155	ATP binding cassette subfamily G member 8	Mus musculus	67-72
12368294-8	2002	TLC analysis of (14)C-labeled bile acids synthesized in cells overexpressing StAR showed a 5-fold increase in muricholic acid; in chloroform-extractable products, a dramatic increase was seen in bile acid biosynthesis intermediates (27- and 7,27-hydroxycholesterol).	muricholic acid	110-125	steroidogenic acute regulatory protein	Rattus norvegicus	77-81
10702212-8	2000	Ursodeoxycholic acid (UDC) and hyocholic acid (HC) feeding increased CYP8b1 SAs by 119% +/- 21% and 65% +/- 18%, respectively.	muricholic acid	31-45	cytochrome P450 family 8 subfamily B member 1	Rattus norvegicus	69-75
34438105-0	2021	Cyp2c-deficiency depletes muricholic acids and protects against high fat diet-induced obesity in male mice but promotes liver damage.	muricholic acid	26-42	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	0-5
35470044-1	2022	Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA).	muricholic acid	82-98	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	0-7
3182806-10	1988	The presence of relatively high proportions of hyocholic acid (often greater than cholic acid) and several 1 beta-hydroxycholanoic acid isomers indicates that C-1 and C-6 hydroxylation are important pathways in bile acid synthesis during development.	muricholic acid	47-61	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	159-170
6313363-6	1983	The ratio of the amount of conjugated cholic acid to conjugated chenodeoxycholic acid + conjugated beta-muricholic acid produced, an indication of the activity of 7 alpha-hydroxycholest-4-en-3-one 12 alpha-hydroxylase, was raised by Bt2cAMP in hepatocytes from soft-diet-fed but not in those from cholestyramine-fed rats.	muricholic acid	99-119	cytochrome P450 family 8 subfamily B member 1	Rattus norvegicus	163-217
33645063-8	2021	Elevated free bile acid levels were observed in TSG-treated groups, including beta-muricholic acid(beta-MCA), ursodeoxycholic acid(UDCA), hyodeoxycholic acid(HDCA), chenodeoxycholic acid(CDCA), deoxcholic acid(DCA) in serum and beta-MCA, CDCA in liver.	muricholic acid	78-98	twisted gastrulation BMP signaling modulator 1	Mus musculus	48-51
31506275-4	2020	CYP2C70 was recently proposed to catalyze the formation of rodent-specific muricholic acids (MCAs).	muricholic acid	75-91	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	0-7
31506275-4	2020	CYP2C70 was recently proposed to catalyze the formation of rodent-specific muricholic acids (MCAs).	muricholic acid	93-97	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	0-7
31506275-7	2020	Tracer studies demonstrated that, in vivo, CYP2C70 catalyzes the formation of betaMCA primarily by sequential 6beta- hydroxylation and C7-epimerization of CDCA, generating alphaMCA as an intermediate metabolite.	muricholic acid	78-85	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	43-50
31645370-2	2020	Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs).	muricholic acid	122-138	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	82-89
31645370-2	2020	Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs).	muricholic acid	140-144	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	82-89
34236487-6	2021	Identification of Cyp2c70 as the enzyme responsible for the generation of hydrophilic mouse/rat-specific muricholic acids has allowed the generation of murine models with a human-like bile acid composition.	muricholic acid	105-121	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	18-25
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	muricholic acid	141-157	nuclear receptor subfamily 1, group H, member 3	Mus musculus	33-36
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	muricholic acid	141-157	nuclear receptor subfamily 1, group H, member 4	Mus musculus	181-184
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	muricholic acid	141-157	nuclear receptor subfamily 1, group H, member 4	Mus musculus	221-224
34281217-9	2021	CONCLUSIONS: These coordinated events are mediated by increased muricholic acid levels which inhibit FXR signaling in favor of LXR and SREBP2 signaling to promote efficient fecal and urinary elimination of cholesterol and neo-synthesized bile acids.	muricholic acid	64-79	nuclear receptor subfamily 1, group H, member 4	Mus musculus	101-104
34281217-9	2021	CONCLUSIONS: These coordinated events are mediated by increased muricholic acid levels which inhibit FXR signaling in favor of LXR and SREBP2 signaling to promote efficient fecal and urinary elimination of cholesterol and neo-synthesized bile acids.	muricholic acid	64-79	nuclear receptor subfamily 1, group H, member 3	Mus musculus	127-130
34281217-9	2021	CONCLUSIONS: These coordinated events are mediated by increased muricholic acid levels which inhibit FXR signaling in favor of LXR and SREBP2 signaling to promote efficient fecal and urinary elimination of cholesterol and neo-synthesized bile acids.	muricholic acid	64-79	sterol regulatory element binding factor 2	Mus musculus	135-141
34862975-3	2022	This protective mechanism is mediated by suppression of FXR signaling in the liver by muricholic acids (MCAs) generated in mice from chenodeoxycholic acid (CDCA).	muricholic acid	86-102	nuclear receptor subfamily 1, group H, member 4	Mus musculus	56-59
34862975-3	2022	This protective mechanism is mediated by suppression of FXR signaling in the liver by muricholic acids (MCAs) generated in mice from chenodeoxycholic acid (CDCA).	muricholic acid	104-108	nuclear receptor subfamily 1, group H, member 4	Mus musculus	56-59
33338411-0	2021	Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.	muricholic acid	0-14	G protein-coupled bile acid receptor 1	Mus musculus	70-74
33338411-0	2021	Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.	muricholic acid	0-14	nuclear receptor subfamily 1, group H, member 4	Mus musculus	79-82
33075001-7	2021	Identification of Cyp2c70 as the enzyme responsible for generation of hydrophilic mouse/rat-specific muricholic acids has allowed the generation of murine models with a human-like bile acid composition.	muricholic acid	101-117	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	18-25
33303970-6	2021	Considering that a short stress enhanced hepatic CYP7A1 protein levels in normal mice and corticosterone increased CYP7A1 protein levels in primary mouse hepatocytes, the enhanced Cyp7a1 expression was postulated to be involved in the chronic stress-increased hepatic betaMCA level.	muricholic acid	268-275	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	180-186
33309945-4	2021	Cyp2c70-ablation in mice prevents synthesis of mouse/rat-specific muricholic acids (MCAs), but potential (patho)physiological consequences of their absence are unknown.	muricholic acid	66-82	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	0-7
33309945-4	2021	Cyp2c70-ablation in mice prevents synthesis of mouse/rat-specific muricholic acids (MCAs), but potential (patho)physiological consequences of their absence are unknown.	muricholic acid	84-88	cytochrome P450, family 2, subfamily c, polypeptide 70	Mus musculus	0-7
33368684-5	2021	Mechanistically, we found that Gpbar1-/- mice lack the expression of Cyp2c70 a gene essential for generation of muricholic acids which are FXR antagonists, and have an FXR-biased bile acid pool.	muricholic acid	112-128	G protein-coupled bile acid receptor 1	Mus musculus	31-37
33368684-5	2021	Mechanistically, we found that Gpbar1-/- mice lack the expression of Cyp2c70 a gene essential for generation of muricholic acids which are FXR antagonists, and have an FXR-biased bile acid pool.	muricholic acid	112-128	nuclear receptor subfamily 1, group H, member 4	Mus musculus	139-142
32341465-8	2020	Farnesoid X receptor (FXR) inhibitor glycine-beta-muricholic acid or FXR knockdown reversed the downregulation of PepT1 expression by CDCA and GW4064 (another FXR agonist).	muricholic acid	45-65	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	0-20
32341465-8	2020	Farnesoid X receptor (FXR) inhibitor glycine-beta-muricholic acid or FXR knockdown reversed the downregulation of PepT1 expression by CDCA and GW4064 (another FXR agonist).	muricholic acid	45-65	nuclear receptor subfamily 1 group H member 4	Homo sapiens	22-25
32341465-8	2020	Farnesoid X receptor (FXR) inhibitor glycine-beta-muricholic acid or FXR knockdown reversed the downregulation of PepT1 expression by CDCA and GW4064 (another FXR agonist).	muricholic acid	45-65	solute carrier family 15 member 1	Homo sapiens	114-119
30933435-6	2019	FXR deficiency also increased total BAs and taurine-b-muricholic acid, but these animals remained hyperglycemic.	muricholic acid	54-69	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3