PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
4046325-3	1985	The in situ activity of the highly active cortical enzyme prolidase was determined (1.8 nmoles/min/mg wet kidney wt) by exploiting the marked difference in the spectral features of glycyl-L-proline and that of the free amino acids.	glycylproline	181-197	xaa-Pro dipeptidase	Oryctolagus cuniculus	58-67
3139929-3	1988	Both normal and the patients" mother"s prolidase activity against gly-pro was reduced about 20% at 60 degrees C compared to the activity at 37 degrees C, but the addition of Mn2+ at 55 degrees C increased the activity about 1.8-fold, whereas prolidase activity of patients could not be increased by the addition of Mn2+.	glycylproline	66-73	peptidase D	Homo sapiens	39-48
3139929-3	1988	Both normal and the patients" mother"s prolidase activity against gly-pro was reduced about 20% at 60 degrees C compared to the activity at 37 degrees C, but the addition of Mn2+ at 55 degrees C increased the activity about 1.8-fold, whereas prolidase activity of patients could not be increased by the addition of Mn2+.	glycylproline	66-73	peptidase D	Homo sapiens	242-251
6123345-0	1982	Enzymehistochemical staining of T mu lymphocytes for glycyl-proline-4-methoxy-beta-naphthylamide-peptidase (DAP IV).	glycylproline	53-67	death associated protein	Homo sapiens	108-111
6743286-10	1984	At concentrations of the dipeptide that saturated prolidase, hydrolysis of glycyl-L-proline by whole cells was approximately 130 times slower than by lysates.	glycylproline	75-91	peptidase D	Homo sapiens	50-59
6123345-1	1982	Human T mu lymphocytes are detected in a histochemical reaction with glycyl-proline-4-methoxy-beta-naphthylamide-peptidase (DAP IV; EC 3.4.14.4).	glycylproline	69-83	death associated protein	Homo sapiens	124-127
32018147-3	2020	Breast-feeding exclusively for the first year of postpartum life or supplementation with oral agents to raise the serum IGF1 level, such a cyclo-glycylproline, could be helpful for this purpose.	glycylproline	139-158	insulin like growth factor 1	Homo sapiens	120-124
13174568-0	1954	Specificity of prolidase: effect of alterations in the pyrrolidine ring of glycyl-L-proline.	glycylproline	75-91	peptidase D	Homo sapiens	15-24
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	glycylproline	88-102	proline dehydrogenase 1	Homo sapiens	34-39
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	glycylproline	88-102	peptidase D	Homo sapiens	77-86
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	glycylproline	104-106	proline dehydrogenase 1	Homo sapiens	34-39
32918543-4	2020	In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE).	glycylproline	104-106	peptidase D	Homo sapiens	77-86
28942439-3	2017	We have used inhibitor of proline utilization in collagen biosynthesis, 2-metoxyestradiol (MOE), inhibitor of prolidase that generate proline, rapamycin (Rap) and glycyl-proline (GlyPro), substrate for prolidase.	glycylproline	163-177	peptidase D	Homo sapiens	110-119
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	16-30	peptidase D	Homo sapiens	54-63
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	16-30	peptidase D	Homo sapiens	130-139
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	16-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-216
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	16-30	autophagy related 7	Homo sapiens	224-228
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	16-30	beclin 1	Homo sapiens	233-241
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	32-38	peptidase D	Homo sapiens	54-63
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	32-38	peptidase D	Homo sapiens	130-139
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	32-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-216
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	32-38	autophagy related 7	Homo sapiens	224-228
29568391-6	2018	In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells.	glycylproline	32-38	beclin 1	Homo sapiens	233-241
29568391-7	2018	In MCF-7 cells, GlyPro increased collagen biosynthesis, concentration of proline and expression of caspase-3, cleaved caspases -3 and -9, iNOS, NF-kappaB, COX-2 and AMPKbeta.	glycylproline	16-22	caspase 3	Homo sapiens	99-136
29568391-7	2018	In MCF-7 cells, GlyPro increased collagen biosynthesis, concentration of proline and expression of caspase-3, cleaved caspases -3 and -9, iNOS, NF-kappaB, COX-2 and AMPKbeta.	glycylproline	16-22	inositol-3-phosphate synthase 1	Homo sapiens	138-142
29568391-7	2018	In MCF-7 cells, GlyPro increased collagen biosynthesis, concentration of proline and expression of caspase-3, cleaved caspases -3 and -9, iNOS, NF-kappaB, COX-2 and AMPKbeta.	glycylproline	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
29568391-7	2018	In MCF-7 cells, GlyPro increased collagen biosynthesis, concentration of proline and expression of caspase-3, cleaved caspases -3 and -9, iNOS, NF-kappaB, COX-2 and AMPKbeta.	glycylproline	16-22	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	165-173
28942439-11	2017	DNA biosynthesis was similarly inhibited by Rap and MOE in both cell lines, but GlyPro inhibited the process only in MCF-7shPRODH/POX and MOE+GlyPro only in MCF-7 cells.	glycylproline	80-86	proline dehydrogenase 1	Homo sapiens	130-133
29568391-9	2018	However, GlyPro induced apoptosis in PRODH/POX-expressing MCF-7 cells as detected by up-regulation of active caspases -3 and -9.	glycylproline	9-15	proline dehydrogenase 1	Homo sapiens	37-42
29568391-9	2018	However, GlyPro induced apoptosis in PRODH/POX-expressing MCF-7 cells as detected by up-regulation of active caspases -3 and -9.	glycylproline	9-15	proline dehydrogenase 1	Homo sapiens	43-46
29568391-9	2018	However, GlyPro induced apoptosis in PRODH/POX-expressing MCF-7 cells as detected by up-regulation of active caspases -3 and -9.	glycylproline	9-15	caspase 3	Homo sapiens	109-127
26090777-7	2015	Furthermore Gly-Pro analog 3 potentiated the effect of PGF2alpha on Galphaq mediated ERK1/2 activation.	glycylproline	12-19	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	68-75
26090777-7	2015	Furthermore Gly-Pro analog 3 potentiated the effect of PGF2alpha on Galphaq mediated ERK1/2 activation.	glycylproline	12-19	mitogen-activated protein kinase 3	Mus musculus	85-91
21425789-1	2011	The catalytic hydrolysis of the Gly-Pro substrate by the bimetallic prolidase active site model cluster has been investigated at the DF/B3LYP level of theory, in order to provide fundamental insights into the still poorly understood mechanism of prolidase catalysis.	glycylproline	32-39	peptidase D	Homo sapiens	68-77
24291245-2	2014	In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 mug/kg) of peptides using real-time PCR method.	glycylproline	68-75	caspase 1	Mus musculus	109-114
24291245-2	2014	In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 mug/kg) of peptides using real-time PCR method.	glycylproline	68-75	interleukin 2 receptor, gamma chain	Mus musculus	116-121
24291245-2	2014	In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 mug/kg) of peptides using real-time PCR method.	glycylproline	68-75	chemokine (C motif) receptor 1	Mus musculus	127-131
24291245-5	2014	We found a significant alteration in the mRNA level of the Il2rg gene at early time points after Selank and Gly-Pro administration and an almost equal reduction in the Xcr1 mRNA level 90 min after the administration of Selank and its fragment.	glycylproline	108-115	interleukin 2 receptor, gamma chain	Mus musculus	59-64
24248382-5	2013	Furthermore, we show that RAN translation occurs from both sense and antisense expansion transcripts, resulting in the expression of six RAN proteins (antisense: Pro-Arg, Pro-Ala, Gly-Pro; and sense: Gly-Ala, Gly-Arg, Gly-Pro).	glycylproline	180-187	RAN, member RAS oncogene family	Homo sapiens	26-29
24248382-5	2013	Furthermore, we show that RAN translation occurs from both sense and antisense expansion transcripts, resulting in the expression of six RAN proteins (antisense: Pro-Arg, Pro-Ala, Gly-Pro; and sense: Gly-Ala, Gly-Arg, Gly-Pro).	glycylproline	218-225	RAN, member RAS oncogene family	Homo sapiens	26-29
22772900-0	2013	Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.	glycylproline	48-55	vascular endothelial growth factor A	Rattus norvegicus	77-81
22316150-5	2012	CypA has been shown to aid HIV-1 replication by catalyzing the cis/trans isomerization of a conserved Gly-Pro motif in the Nterminal domain of HIV-1 capsid (CA) protein.	glycylproline	102-109	peptidylprolyl isomerase A	Homo sapiens	0-4
21963115-3	2011	In this study we investigate whether the notoriously low affinity inhibitory interaction of linear proline-containing peptides with the active site of CypA can be increased through a combination of a high cis/trans ratio and a negatively charged C-terminus as has been recently reported for Trp-Gly-Pro.	glycylproline	295-302	peptidylprolyl isomerase A	Homo sapiens	151-155
25008848-3	2014	The uptake was pH-dependent, being highest at pH 6.0, and was significantly decreased in the presence of PEPT1 inhibitors [glycylsarcosine (Gly-Sar), cephalexin, valaciclovir, glycylglycine, and glycylproline].	glycylproline	195-208	solute carrier family 15 member 1	Homo sapiens	105-110
23549681-4	2013	However, in MDA-MB-231 cells (expressing high prolidase activity) cultured in the presence of prolidase substrates, Gly-Pro or Gly-HyPro, HIF-1alpha expression was induced in a dose-dependent manner, independently of estrogen receptor activation.	glycylproline	116-123	peptidase D	Homo sapiens	46-55
23549681-4	2013	However, in MDA-MB-231 cells (expressing high prolidase activity) cultured in the presence of prolidase substrates, Gly-Pro or Gly-HyPro, HIF-1alpha expression was induced in a dose-dependent manner, independently of estrogen receptor activation.	glycylproline	116-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
22853447-8	2012	The results showed that in hPAT1 expressing oocytes Gly-Tyr, Gly-Pro, and Gly-Phe inhibited currents induced by drug substances.	glycylproline	61-68	solute carrier family 36 member 1	Homo sapiens	27-32
22853447-9	2012	In Caco-2 cell monolayers, Gly-Gly, Gly-Sar, and Gly-Pro significantly inhibited the PAT1 mediated absorptive transepithelial transport of gaboxadol; however, when orally administered to rats, Gly-Gly, Gly-Sar, Gly-Pro, or Gly-Tyr did not alter the pharmacokinetic profile of gaboxadol.	glycylproline	49-56	solute carrier family 36 member 1	Homo sapiens	85-89
22853447-9	2012	In Caco-2 cell monolayers, Gly-Gly, Gly-Sar, and Gly-Pro significantly inhibited the PAT1 mediated absorptive transepithelial transport of gaboxadol; however, when orally administered to rats, Gly-Gly, Gly-Sar, Gly-Pro, or Gly-Tyr did not alter the pharmacokinetic profile of gaboxadol.	glycylproline	211-218	solute carrier family 36 member 1	Homo sapiens	85-89
21425789-1	2011	The catalytic hydrolysis of the Gly-Pro substrate by the bimetallic prolidase active site model cluster has been investigated at the DF/B3LYP level of theory, in order to provide fundamental insights into the still poorly understood mechanism of prolidase catalysis.	glycylproline	32-39	peptidase D	Homo sapiens	246-255
18550075-2	2008	The different effects of reaction conditions including the concentration of Mn(2+), incubation temperature and pH on prolidase (PLD, EC 3.4.13.9) activity in erythrocyte lysates against three different substrates, Gly-Pro, Val-Pro and Leu-Pro were investigated.	glycylproline	214-221	peptidase D	Homo sapiens	117-126
20880398-7	2010	KEY RESULTS In SLC36A1-expressing oocytes, an inward current was induced by Gly-Sar, Gly-Gly, delta-aminolevulinic acid, beta-aminoethylglycine, delta-aminopentanoic acid, GABA, Gly and Pro, whereas Val, Leu, mannitol, 5-HTP and the dipeptides Gly-Ala, Gly-Pro and Gly-Phe did not evoke currents.	glycylproline	253-260	solute carrier family 36 member 1	Homo sapiens	15-22
19263194-2	2009	The activity of prolidase I against glycylproline was strongly enhanced by D: -methionine.	glycylproline	36-49	peptidase D	Homo sapiens	16-25
18410982-1	2009	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N"-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	glycylproline	0-7	dipeptidyl peptidase 4	Homo sapiens	224-247
18410982-1	2009	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N"-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	glycylproline	0-7	tripeptidyl peptidase 1	Homo sapiens	252-275
19809172-3	2009	Although the ACE inhibitory activity of Gly-Pro (IC(50)=360 microM) was not potent, Gly-Pro exists in collagen as a large number of repeated sequences.	glycylproline	40-47	angiotensin I converting enzyme	Rattus norvegicus	13-16
18550075-2	2008	The different effects of reaction conditions including the concentration of Mn(2+), incubation temperature and pH on prolidase (PLD, EC 3.4.13.9) activity in erythrocyte lysates against three different substrates, Gly-Pro, Val-Pro and Leu-Pro were investigated.	glycylproline	214-221	peptidase D	Homo sapiens	128-131
15736956-5	2005	Our results show that replacement of H295 with glutamine, an amino acid residue that cannot be protonated, generates a fully functional transporter with transport kinetics that are close to those of the wild-type EAAC1.	glycylproline	37-41	solute carrier family 1 member 1	Homo sapiens	213-218
17554807-4	2007	In this study, we used porcine brush-border membrane (BBM) vesicles to assess Gly-Pro-Hyp uptake, because these vesicles can structurally and functionally mimic in vivo conditions of human intestinal apical membranes.	glycylproline	78-85	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	86-89
17554807-7	2007	We found that the transcellular transport of Pro-Hyp across the BBM was inhibited by the addition of a competitive substrate (Gly-Pro) for peptide transporter (PEPT1) and was pH-dependent.	glycylproline	126-133	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	49-52
17554807-7	2007	We found that the transcellular transport of Pro-Hyp across the BBM was inhibited by the addition of a competitive substrate (Gly-Pro) for peptide transporter (PEPT1) and was pH-dependent.	glycylproline	126-133	solute carrier family 15 member 1	Homo sapiens	160-165
16899234-8	2007	On the other hand, prolidase activity against glycylproline was enhanced by L-methionine, D-methionine, D,L-methionine, D,L-homocysteine thiolactone and D,L-ethionine.	glycylproline	46-59	peptidase D	Homo sapiens	19-28
16009141-4	2005	RESULTS: The activities of prolidase I and II against glycylproline and methionylproline were enhanced by glycine, L- and D-isoforms of alanine and serine and D-isoforms of valine, leucine and isoleucine.	glycylproline	54-67	peptidase D	Homo sapiens	27-36
15530480-4	2004	RESULTS: Prolidase activity against glycylproline in erythrocytes from normal human was strongly enhanced by glycine, L-alanine, L-serine with MnCl(2), but the activity was strongly inhibited by L-valine, and L-leucine.	glycylproline	36-49	peptidase D	Homo sapiens	9-18
15728907-3	2005	The results show that when the tripeptide amide came into contact with the apical enterocyte membrane, it was degraded by CD26 (dipeptidyl peptidase IV) to glycylproline and the antiretrovirally active metabolite glycinamide.	glycylproline	156-169	dipeptidyl peptidase 4	Homo sapiens	122-126
15728907-3	2005	The results show that when the tripeptide amide came into contact with the apical enterocyte membrane, it was degraded by CD26 (dipeptidyl peptidase IV) to glycylproline and the antiretrovirally active metabolite glycinamide.	glycylproline	156-169	dipeptidyl peptidase 4	Homo sapiens	128-151
15804176-3	2005	RT-PCR expression of prolidase and hydrolytic activity against N-glycyl-l-proline (GLY-PRO), a standard substrate of prolidase, determined in tumor cell lines, exhibited a high correlation (r(2) = 0.95).	glycylproline	63-81	peptidase D	Homo sapiens	21-30
15804176-3	2005	RT-PCR expression of prolidase and hydrolytic activity against N-glycyl-l-proline (GLY-PRO), a standard substrate of prolidase, determined in tumor cell lines, exhibited a high correlation (r(2) = 0.95).	glycylproline	63-81	peptidase D	Homo sapiens	117-126
15804176-3	2005	RT-PCR expression of prolidase and hydrolytic activity against N-glycyl-l-proline (GLY-PRO), a standard substrate of prolidase, determined in tumor cell lines, exhibited a high correlation (r(2) = 0.95).	glycylproline	83-90	peptidase D	Homo sapiens	21-30
15804176-3	2005	RT-PCR expression of prolidase and hydrolytic activity against N-glycyl-l-proline (GLY-PRO), a standard substrate of prolidase, determined in tumor cell lines, exhibited a high correlation (r(2) = 0.95).	glycylproline	83-90	peptidase D	Homo sapiens	117-126
15530480-8	2004	CONCLUSION: Prolidase activity against glycylproline in normal human erythrocytes and against methionylproline from the prolidase-deficient patient was enhanced strongly by glycine, alanine and serine with MnCl(2).	glycylproline	39-52	peptidase D	Homo sapiens	12-21
15530480-8	2004	CONCLUSION: Prolidase activity against glycylproline in normal human erythrocytes and against methionylproline from the prolidase-deficient patient was enhanced strongly by glycine, alanine and serine with MnCl(2).	glycylproline	39-52	peptidase D	Homo sapiens	120-129
15137808-1	2004	In an effort to develop natural and nontoxic inhibitors on the activity of mushroom polyphenol oxidase (PPO) the effect of various glycyl-dipeptides (GlyAsp, GlyGly, GlyHis, GlyLeu, GlyLys, GlyPhe, GlyPro, GlyTyr) was investigated.	glycylproline	198-204	catechol oxidase B, chloroplastic	Solanum tuberosum	104-107
15183349-2	2004	The lymphocyte surface glycoprotein marker CD26, which is identical to dipeptidyl peptidase IV, efficiently converted GPG-NH2 to G-NH2 releasing the dipeptide GP-OH.	glycylproline	159-164	dipeptidyl peptidase 4	Homo sapiens	43-47
15183349-2	2004	The lymphocyte surface glycoprotein marker CD26, which is identical to dipeptidyl peptidase IV, efficiently converted GPG-NH2 to G-NH2 releasing the dipeptide GP-OH.	glycylproline	159-164	dipeptidyl peptidase 4	Homo sapiens	71-94
15147195-2	2004	It has recently been shown that CypA efficiently catalyzes the cis/trans isomerization of Gly-Pro(222) within the isolated N-terminal domain of capsid (CA(N)).	glycylproline	90-97	peptidylprolyl isomerase A	Homo sapiens	32-36
15147195-5	2004	The results discussed herein strongly suggest that Gly-Pro(222) located within the N-terminal domain of the capsid is the preferential site for CypA binding and catalysis and that catalysis of Gly-Pro(222) is unaffected by maturational processing at the N-terminus of the capsid.	glycylproline	51-58	peptidylprolyl isomerase A	Homo sapiens	144-148
11680815-3	2001	The susceptibility of MEL-PRO to the action of prolidase was found to be similar, compared to glycyl-proline--the most abundant, endogenous substrate for prolidase and about 6-fold higher compared to its substrate--glycyl-hydroxyproline.	glycylproline	94-108	peptidase D	Homo sapiens	154-163
14580160-4	2003	The activity of prolidase II was maintained at about 76% by pre-incubation with MnCl2; it was then activated up to 140% by treatment with mercaptoethanol for 60 minutes at 37 degrees C. Normal prolidases I and II showed the highest activity against glycylproline or methionylproline in the presence of MnCl2.	glycylproline	249-262	peptidase D	Homo sapiens	16-25
14580160-5	2003	The activity of prolidase I against glycylproline was enhanced strongly by glycine and MnCl2, but not activated in the absence of MnCl2.	glycylproline	36-49	peptidase D	Homo sapiens	16-25
14580160-6	2003	The activity of prolidase II against methionylproline was enhanced three-fold in the presence of glycine and MnCl2, but its activity against glycylproline was very low even in the presence of MnCl2.	glycylproline	141-154	peptidase D	Homo sapiens	16-25
12415572-6	2002	Glycyl proline, a dipeptide transport system (PEPT1) substrate, inhibited ceftibuten uptake into Caco-2 cells.	glycylproline	0-14	solute carrier family 15 member 1	Homo sapiens	46-51
11231127-7	2001	Abolishing self assembly of the EpoR TM by a double point mutation (Leu 240-Leu 241 mutated to Gly-Pro) impairs signal transduction by EpoR in hematopoietic cells and the formation of erythroid colonies upon reconstitution in erythroid progenitor cells from EpoR(-/-) mice.	glycylproline	95-102	erythropoietin receptor	Mus musculus	32-36
11231127-7	2001	Abolishing self assembly of the EpoR TM by a double point mutation (Leu 240-Leu 241 mutated to Gly-Pro) impairs signal transduction by EpoR in hematopoietic cells and the formation of erythroid colonies upon reconstitution in erythroid progenitor cells from EpoR(-/-) mice.	glycylproline	95-102	erythropoietin receptor	Mus musculus	135-139
11231127-7	2001	Abolishing self assembly of the EpoR TM by a double point mutation (Leu 240-Leu 241 mutated to Gly-Pro) impairs signal transduction by EpoR in hematopoietic cells and the formation of erythroid colonies upon reconstitution in erythroid progenitor cells from EpoR(-/-) mice.	glycylproline	95-102	erythropoietin receptor	Mus musculus	135-139
9972056-7	1998	It has been presented that product of synthesis, N-(anthraquinone-2-carbonyl)-L-proline evokes susceptibility to the action of purified prolidase, comparable to the susceptibility of glycyl-L-proline (standard substrate for prolidase).	glycylproline	183-199	peptidase D	Homo sapiens	136-145
10026140-5	1999	Peptides corresponding to these regions showed higher affinities (Kd approximately 0.3 microM) for both CyPA and cyclophilin B than the best peptide derived from the Gly-Pro90 site ( approximately 8 microM) and thus revealed new sequence motifs flanking Gly-Pro that are important for tight interaction of peptide ligands with cyclophilins.	glycylproline	166-173	peptidylprolyl isomerase A	Homo sapiens	104-108
10026140-5	1999	Peptides corresponding to these regions showed higher affinities (Kd approximately 0.3 microM) for both CyPA and cyclophilin B than the best peptide derived from the Gly-Pro90 site ( approximately 8 microM) and thus revealed new sequence motifs flanking Gly-Pro that are important for tight interaction of peptide ligands with cyclophilins.	glycylproline	166-173	peptidylprolyl isomerase A	Homo sapiens	327-339
10582130-1	1999	Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins.	glycylproline	0-16	peptidase D	Homo sapiens	95-104
10582130-1	1999	Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins.	glycylproline	18-25	peptidase D	Homo sapiens	95-104
11012666-8	2000	Purified recombinant DPP8 hydrolyzed the DPPIV substrates Ala-Pro, Arg-Pro and Gly-Pro.	glycylproline	79-86	dipeptidyl peptidase 8	Homo sapiens	21-25
11012666-8	2000	Purified recombinant DPP8 hydrolyzed the DPPIV substrates Ala-Pro, Arg-Pro and Gly-Pro.	glycylproline	79-86	dipeptidyl peptidase 4	Homo sapiens	41-46
7837269-8	1995	Deletion of one of five Gly-Pro rich octarepeats from the N-terminus of PrP was seen in some species, while squirrel monkeys had an additional octarepeat; squirrel monkeys have been frequently used as experimental hosts for transmission of human prions.	glycylproline	24-31	prion protein	Homo sapiens	72-75
9016720-9	1997	CONCLUSIONS: The unfavorable backbone conformation of Gly89 of the gag 25-mer fragment suggests that binding between HIV-1 gag protein and CyPA requires a special sequence, Gly-Pro.	glycylproline	173-180	Pr55(Gag)	Human immunodeficiency virus 1	67-70
9016720-9	1997	CONCLUSIONS: The unfavorable backbone conformation of Gly89 of the gag 25-mer fragment suggests that binding between HIV-1 gag protein and CyPA requires a special sequence, Gly-Pro.	glycylproline	173-180	Pr55(Gag)	Human immunodeficiency virus 1	123-126
9016720-9	1997	CONCLUSIONS: The unfavorable backbone conformation of Gly89 of the gag 25-mer fragment suggests that binding between HIV-1 gag protein and CyPA requires a special sequence, Gly-Pro.	glycylproline	173-180	peptidylprolyl isomerase A	Homo sapiens	139-143
8951616-4	1996	Gly-X dipeptides increase not only an apparent Km of serum DPPIV for glycyl-L-proline 3,5-dibromo-4-hydroxyanilide nearly 10-fold, but also an apparent kcat nearly 4-fold.	glycylproline	69-85	dipeptidyl peptidase 4	Homo sapiens	59-64
8951616-5	1996	This mechanism is unclear, but one possibility is that Gly-Pro from substrate might bind amino acids or dipeptides instead of water molecules as DPPIV transpeptidyl activity reported previously.	glycylproline	55-62	dipeptidyl peptidase 4	Homo sapiens	145-150
7714663-1	1995	We synthesized a new substrate glycyl-L-proline 3,5-dibromo-4-hydroxyanilide (Gly-Pro-DBAP), for dipeptidyl peptidase IV (DPPIV).	glycylproline	31-47	dipeptidyl peptidase 4	Homo sapiens	97-120
7714663-1	1995	We synthesized a new substrate glycyl-L-proline 3,5-dibromo-4-hydroxyanilide (Gly-Pro-DBAP), for dipeptidyl peptidase IV (DPPIV).	glycylproline	31-47	dipeptidyl peptidase 4	Homo sapiens	122-127
1536787-2	1992	Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively.	glycylproline	53-67	peptidase D	Homo sapiens	0-9
15378943-6	1994	RESULTS: Prolidase activity was found to be deficient, especially against gly-pro.	glycylproline	74-81	peptidase D	Homo sapiens	9-18
8390680-2	1993	However, a Gly-Pro sequence within the TM domain of the insulin receptor is predicted to act as a helix breaker.	glycylproline	11-18	insulin receptor	Homo sapiens	56-72
8390680-11	1993	Invariance of Gly-Pro within insulin receptor TM domain sequences suggests a physiologic advantage for submaximal rates of receptor internalization.	glycylproline	14-21	insulin	Homo sapiens	29-36
1645541-2	1991	The reaction of GlyPro with sulfite in the presence of Co(II) or peroxidase/H2O2 led to Gly liberation, suggesting the oxidative cleavage of protein at Pro residues.	glycylproline	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
1686804-1	1991	Dipeptidyl-Peptidase IV was purified from pig kidney by ammonium sulfate fractionation, gel filtration, QAE-cellulose chromatography and affinity columns with Gly-Pro- and Concanavalin A-Sepharose.	glycylproline	159-166	dipeptidyl peptidase 4	Sus scrofa	0-23
2317925-4	1990	The Km values for Gly-Pro of the control"s and the patient"s mother"s prolidase I were 2.90 +/- 0.22 and 2.88 +/- 0.27 mM, but the Vmax values for Gly-Pro of the mother"s enzyme was reduced about 30% compared to that of control enzymes (mother: 6.02 units/mg protein, control: 22.21 units/mg protein).	glycylproline	18-25	peptidase D	Homo sapiens	70-79
2073490-5	1990	The substrate specificity of partially purified prolidase-I and II in control fibroblasts was estimated against Gly-Pro, Ala-Pro, Met-Pro.	glycylproline	112-119	peptidase D	Homo sapiens	48-57
3205627-6	1988	As a consequence, the activity of prolidase in hemolysates increases to 159 mumol glycyl-L-proline hydrolyzed/h/ml compared to 5 mumol/h/ml for hemolysates of cells incubated in the absence of Mn++.	glycylproline	82-98	peptidase D	Homo sapiens	34-43