PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34817267-7	2022	Our results show demonstrate that both mitochondrial respiration capacity and reactive oxygen species emission are altered with Fmr1 deletion in astrocytes and these changes were dependent upon both sexual dimorphism and oxygen availability.	oxygen species	87-101	fragile X messenger ribonucleoprotein 1	Homo sapiens	128-132
1877661-3	1991	Activated oxygen species were generated on the cerebral surface using xanthine oxidase and hypoxanthine.	oxygen species	10-24	xanthine dehydrogenase	Sus scrofa	70-86
33765083-6	2021	These data provided evidence of the dual role of NRF2 in protecting both the invading pathogen from reactive oxygen species and the host from an excess of the TNF-alpha destructive pro-inflammatory cytokine.	oxygen species	109-123	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
32796025-3	2020	Specifically, we observed that several inhibitors known to block the enzymatic function of fibroblast activation protein-alpha (FAP-alpha) were able to block CD44-mediated reactive oxygen species production and cell death, but not FAS receptor-mediated apoptosis.	oxygen species	181-195	fibroblast activation protein alpha	Homo sapiens	91-126
32796025-3	2020	Specifically, we observed that several inhibitors known to block the enzymatic function of fibroblast activation protein-alpha (FAP-alpha) were able to block CD44-mediated reactive oxygen species production and cell death, but not FAS receptor-mediated apoptosis.	oxygen species	181-195	fibroblast activation protein alpha	Homo sapiens	128-137
32796025-3	2020	Specifically, we observed that several inhibitors known to block the enzymatic function of fibroblast activation protein-alpha (FAP-alpha) were able to block CD44-mediated reactive oxygen species production and cell death, but not FAS receptor-mediated apoptosis.	oxygen species	181-195	CD44 molecule (Indian blood group)	Homo sapiens	158-162
2158267-5	1990	Mechanisms responsible for the enhancing effects of interferon-gamma include upregulation of major histocompatibility complex class II antigen expression in the nerve lesion, increased cellular influx of T cells and macrophages, and heightened macrophage activity with enhanced release of toxic oxygen species.	oxygen species	295-309	interferon gamma	Rattus norvegicus	52-68
34874578-3	2022	The current study aims to reveal the underlining mechanisms that caveolin-1 (CAV1)-ROS (reactive oxygen species)-ferroptosis axis affect the process of HNSCC, and discover novo therapeutic targets or strategies.	oxygen species	97-111	caveolin 1	Homo sapiens	65-75
34801596-9	2022	CBR3-AS1 downregulation decreased post-irradiation SOD1 expression, increased gammaH2AX formation, raised levels of reactive oxygen species, and promoted apoptosis.	oxygen species	125-139	carbonyl reductase 3	Homo sapiens	0-4
34801596-9	2022	CBR3-AS1 downregulation decreased post-irradiation SOD1 expression, increased gammaH2AX formation, raised levels of reactive oxygen species, and promoted apoptosis.	oxygen species	125-139	prostaglandin D2 receptor	Homo sapiens	5-8
34874578-3	2022	The current study aims to reveal the underlining mechanisms that caveolin-1 (CAV1)-ROS (reactive oxygen species)-ferroptosis axis affect the process of HNSCC, and discover novo therapeutic targets or strategies.	oxygen species	97-111	caveolin 1	Homo sapiens	77-81
34369274-11	2021	Iron uptake mediated the activation of NADPH oxidase 1 (NOX1) signaling, which induced the release of reactive oxygen species (ROS) and mitochondrial damage.	oxygen species	111-125	NADPH oxidase 1	Homo sapiens	39-54
34924950-8	2021	We observed that P301L tau up-regulates genes associated with reactive oxygen species responsiveness as well as genes involved in dendrite, microtubule, and nuclear body/speckle formation.	oxygen species	71-85	microtubule associated protein tau	Homo sapiens	23-26
34924566-6	2021	GLS inhibition increases reactive oxygen species production, leading to transcriptional activation of AREG through Max-like protein X (MLX) transcription factor.	oxygen species	34-48	glutaminase	Homo sapiens	0-3
34924566-6	2021	GLS inhibition increases reactive oxygen species production, leading to transcriptional activation of AREG through Max-like protein X (MLX) transcription factor.	oxygen species	34-48	amphiregulin	Homo sapiens	102-106
34924566-6	2021	GLS inhibition increases reactive oxygen species production, leading to transcriptional activation of AREG through Max-like protein X (MLX) transcription factor.	oxygen species	34-48	MAX dimerization protein MLX	Homo sapiens	115-133
34924566-6	2021	GLS inhibition increases reactive oxygen species production, leading to transcriptional activation of AREG through Max-like protein X (MLX) transcription factor.	oxygen species	34-48	MAX dimerization protein MLX	Homo sapiens	135-138
34369274-11	2021	Iron uptake mediated the activation of NADPH oxidase 1 (NOX1) signaling, which induced the release of reactive oxygen species (ROS) and mitochondrial damage.	oxygen species	111-125	NADPH oxidase 1	Homo sapiens	56-60
34748911-2	2021	As an effective lifestyle intervention, exercise induces extensive mitochondrial adaptations through vascular mechanical stress and the increased production and release of reactive oxygen species and nitric oxide that activate multiple intracellular signaling pathways, among which peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) plays a critical role.	oxygen species	181-195	PPARG coactivator 1 alpha	Homo sapiens	282-349
34591326-13	2021	Moreover, the reactive oxygen species level was up-regulated in the young and the aged SIRT3-KO groups.	oxygen species	23-37	sirtuin 3	Mus musculus	87-92
34748911-2	2021	As an effective lifestyle intervention, exercise induces extensive mitochondrial adaptations through vascular mechanical stress and the increased production and release of reactive oxygen species and nitric oxide that activate multiple intracellular signaling pathways, among which peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) plays a critical role.	oxygen species	181-195	PPARG coactivator 1 alpha	Homo sapiens	351-361
34884594-6	2021	Increases in beta-galactosidase gene expression and secretion of reactive oxygen species and transforming growth factor-beta1 were also observed.	oxygen species	74-88	galactosidase beta 1	Homo sapiens	13-31
34693848-3	2021	Therapeutic approaches in FRDA have consisted of two different approaches: (1) augmenting or restoring frataxin production and (2) modulating a variety of downstream processes related to mitochondrial dysfunction, including reactive oxygen species production, ferroptosis, or Nrf2 activation.	oxygen species	233-247	frataxin	Homo sapiens	26-30
34811632-6	2021	Intracellular ectopic CCN6 protein localizes to the mitochondria in MDA-MB-231 mesenchymal-like breast cancer cells, increases mitochondrial respiration and generation of reactive oxygen species, and reverses doxorubicin resistance of MBC cells.	oxygen species	180-194	cellular communication network factor 6	Homo sapiens	22-26
34869700-8	2021	Improved outcomes in NEU1 CKO mice subjected to BAPN treatment were associated with the ameliorated vascular inflammation, lowered apoptosis, decreased reactive oxygen species production, mitigated extracellular matrix degradation, and improved M2 macrophage polarization.	oxygen species	161-175	neuraminidase 1	Mus musculus	21-25
34597900-0	2021	Tonsil-derived mesenchymal stem cells incorporated in reactive oxygen species-releasing hydrogel promote bone formation by increasing the translocation of cell surface GRP78.	oxygen species	63-77	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	168-173
34615735-6	2021	Subsequently, it was found that LF binds to TGF-beta receptor III, which induces reactive oxygen species production and diminishes the expression of mTGF-beta-bound latency-associated peptide, leading to the activation of mTGF-beta.	oxygen species	90-104	lactotransferrin	Mus musculus	32-34
34617947-4	2021	It was confirmed from in vitro experiments that CDs-1 could significantly up-regulate the expression of mRNA and the protein of HMOX1, which can increase the expression of HMOX1 by 5 times in a short time, decreasing the reactive oxygen species level in a cellular inflammation model induced by LPS.	oxygen species	230-244	CDP-diacylglycerol synthase 1	Mus musculus	48-53
34617947-4	2021	It was confirmed from in vitro experiments that CDs-1 could significantly up-regulate the expression of mRNA and the protein of HMOX1, which can increase the expression of HMOX1 by 5 times in a short time, decreasing the reactive oxygen species level in a cellular inflammation model induced by LPS.	oxygen species	230-244	heme oxygenase 1	Mus musculus	128-133
34270986-5	2021	Our results also revealed that c-Myc inhibition using 10058-F4 increased the intracellular reactive oxygen species production coupled with suppressed expression of hTERT.	oxygen species	100-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
34481495-4	2021	However, extensive DNA damage caused by high levels of reactive oxygen species can trigger the "hyperactivation" of poly(ADP-ribose) polymerase (PARP), which results in the severe interruption of H2O2 supply and further the reduced efficacy of CDT.	oxygen species	64-78	poly(ADP-ribose) polymerase 1	Homo sapiens	116-143
34482701-11	2021	Conclusions PAT-derived leptin induces myocardial apoptosis in high-fat diet-induced obese rats via activating Janus kinase 2/signal transducer and activator of transcription 3/reactive oxygen species signaling pathway and inhibiting its downstream Na+/K+-ATPase activity.	oxygen species	186-200	leptin	Rattus norvegicus	24-30
34482701-11	2021	Conclusions PAT-derived leptin induces myocardial apoptosis in high-fat diet-induced obese rats via activating Janus kinase 2/signal transducer and activator of transcription 3/reactive oxygen species signaling pathway and inhibiting its downstream Na+/K+-ATPase activity.	oxygen species	186-200	Janus kinase 2	Rattus norvegicus	111-125
34482701-11	2021	Conclusions PAT-derived leptin induces myocardial apoptosis in high-fat diet-induced obese rats via activating Janus kinase 2/signal transducer and activator of transcription 3/reactive oxygen species signaling pathway and inhibiting its downstream Na+/K+-ATPase activity.	oxygen species	186-200	signal transducer and activator of transcription 3	Rattus norvegicus	126-176
34583520-6	2021	AngII increased reactive oxygen species in both groups but with RIalpha dimer formation in WT only.	oxygen species	25-39	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-5
34172832-7	2021	Furthermore, the mRNA of reactive oxygen species-removing enzymes such as superoxide dismutase, heme oxygenase-1, and catalase were downregulated in the DN and clec5a-/- groups but were not changed in the aft3-/- group.	oxygen species	34-48	heme oxygenase 1	Mus musculus	96-112
34172832-7	2021	Furthermore, the mRNA of reactive oxygen species-removing enzymes such as superoxide dismutase, heme oxygenase-1, and catalase were downregulated in the DN and clec5a-/- groups but were not changed in the aft3-/- group.	oxygen species	34-48	catalase	Mus musculus	118-126
34172832-7	2021	Furthermore, the mRNA of reactive oxygen species-removing enzymes such as superoxide dismutase, heme oxygenase-1, and catalase were downregulated in the DN and clec5a-/- groups but were not changed in the aft3-/- group.	oxygen species	34-48	C-type lectin domain family 5, member a	Mus musculus	160-166
34557482-0	2021	Canine IVM With SOF Medium, Insulin-Transferrin-Selenium, and Low O2 Tension Improves Oocyte Meiotic Competence and Decreases Reactive Oxygen Species Levels.	oxygen species	135-149	insulin	Canis lupus familiaris	28-35
34481495-4	2021	However, extensive DNA damage caused by high levels of reactive oxygen species can trigger the "hyperactivation" of poly(ADP-ribose) polymerase (PARP), which results in the severe interruption of H2O2 supply and further the reduced efficacy of CDT.	oxygen species	64-78	poly(ADP-ribose) polymerase 1	Homo sapiens	145-149
34443613-12	2021	In control samples, the expression level of HO-1 was reduced 24 h after MDI induction in comparison with the higher amount of HO-1 protein found at 2 h. The HO-1 decrease was functional by allowing reactive oxygen species to boost and allowing cell proliferation induction at the beginning of MCE phase.	oxygen species	207-221	heme oxygenase 1	Mus musculus	44-48
34218200-3	2021	Here we demonstrated that TRIM31 was significantly downregulated in the ischemic brain and the deficiency of TRIM31 alleviated brain injury induced by middle cerebral artery occlusion by reducing reactive oxygen species production and maintaining mitochondrial homeostasis.	oxygen species	205-219	tripartite motif containing 31	Homo sapiens	26-32
34443613-12	2021	In control samples, the expression level of HO-1 was reduced 24 h after MDI induction in comparison with the higher amount of HO-1 protein found at 2 h. The HO-1 decrease was functional by allowing reactive oxygen species to boost and allowing cell proliferation induction at the beginning of MCE phase.	oxygen species	207-221	heme oxygenase 1	Mus musculus	126-130
34443613-12	2021	In control samples, the expression level of HO-1 was reduced 24 h after MDI induction in comparison with the higher amount of HO-1 protein found at 2 h. The HO-1 decrease was functional by allowing reactive oxygen species to boost and allowing cell proliferation induction at the beginning of MCE phase.	oxygen species	207-221	heme oxygenase 1	Mus musculus	157-161
34458366-7	2021	Compared with the control AF cells, TNF-alpha significantly declined cell proliferation potency and telomerase activity, elevated senescence-associated beta-galactosidase (SA-beta-Gal) activity, upregulated protein expression of senescence markers (p16 and p53), and increased reactive oxygen species (ROS) content and activity of the NF-kappaB pathway.	oxygen species	286-300	tumor necrosis factor	Rattus norvegicus	36-45
34439303-10	2021	In SW620 cells, DJ-1 knockdown induced an incomplete autophagic response that did not affect ATP production; DJ-1 knockdown enhanced intracellular reactive oxygen species generation and damaged mitochondrial accumulation and mitophagy inhibition.	oxygen species	156-170	Parkinsonism associated deglycase	Homo sapiens	16-20
34439303-10	2021	In SW620 cells, DJ-1 knockdown induced an incomplete autophagic response that did not affect ATP production; DJ-1 knockdown enhanced intracellular reactive oxygen species generation and damaged mitochondrial accumulation and mitophagy inhibition.	oxygen species	156-170	Parkinsonism associated deglycase	Homo sapiens	109-113
34445111-5	2021	The sacs-null fish showed motor impairment, hindbrain atrophy, mitochondrial dysfunction, and reactive oxygen species accumulation.	oxygen species	103-117	sacsin molecular chaperone	Danio rerio	4-8
34232130-5	2021	In contrast, benfotiamine dampened inflammation NLRP3 mediated in BV2 cells stimulated with LPS and ATP through reducing mitochondrial reactive oxygen species levels and mitigating autophagy flux defect.	oxygen species	144-158	NLR family, pyrin domain containing 3	Mus musculus	48-53
34440149-7	2021	With regard to the signal transduction pathway, aldosterone suppressed cardiac mitochondria through an MR/MAPK/p38/reactive oxygen species pathway.	oxygen species	124-138	nuclear receptor subfamily 3, group C, member 2	Mus musculus	103-105
34440149-7	2021	With regard to the signal transduction pathway, aldosterone suppressed cardiac mitochondria through an MR/MAPK/p38/reactive oxygen species pathway.	oxygen species	124-138	mitogen-activated protein kinase 14	Mus musculus	111-114
34171753-0	2021	Chitin-derived polymer deacetylation regulates mitochondrial reactive oxygen species dependent cGAS-STING and NLRP3 inflammasome activation.	oxygen species	70-84	NLR family pyrin domain containing 3	Homo sapiens	110-115
34381452-3	2021	Theories explaining activation of the NLRP3 inflammasome include the reactive oxygen species theory, the lysosomal damage theory and the mitochondrial DNA theory.	oxygen species	78-92	NLR family pyrin domain containing 3	Homo sapiens	38-43
34439451-8	2021	These results stay in agreement with transcript-level evaluation (real-time polymerase chain reaction, PCR) of antioxidant enzymes (PRDX1, SOD1, GSS), which protect cells from the reactive oxygen species.	oxygen species	189-203	peroxiredoxin 1	Bos taurus	132-137
34439451-8	2021	These results stay in agreement with transcript-level evaluation (real-time polymerase chain reaction, PCR) of antioxidant enzymes (PRDX1, SOD1, GSS), which protect cells from the reactive oxygen species.	oxygen species	189-203	superoxide dismutase [Cu-Zn]	Bos taurus	139-143
34439451-8	2021	These results stay in agreement with transcript-level evaluation (real-time polymerase chain reaction, PCR) of antioxidant enzymes (PRDX1, SOD1, GSS), which protect cells from the reactive oxygen species.	oxygen species	189-203	glutathione synthetase	Bos taurus	145-148
34219227-4	2022	RIPK3 can modulate mitochondrial function and quality through the regulation of mitochondrial reactive oxygen species production, sequestration of metabolic enzymes and resident mitochondrial proteins, activity of mitochondrial respiratory chain complexes, mitochondrial biogenesis and fatty acid oxidation.	oxygen species	103-117	receptor interacting serine/threonine kinase 3	Homo sapiens	0-5
34145058-4	2021	Inhibition of IRE1alpha diminished production of mitochondrial reactive oxygen species and decreased CASPASE-2 activation, which both contributed to neutrophil antimicrobial activity.	oxygen species	72-86	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	14-23
34262905-5	2021	GDF11 remarkably improved cardiac dysfunction and interstitial fibrosis by reducing the levels of reactive oxygen species and protecting against cardiomyocyte loss.	oxygen species	107-121	growth differentiation factor 11	Homo sapiens	0-5
35405154-6	2022	Zinc also promotes pathological phosphorylation of DeltaK280 in neuronal cells, and aggravates mitochondrial damage and elevates reactive oxygen species production induced by Tau aggregation.	oxygen species	138-152	microtubule associated protein tau	Homo sapiens	175-178
34100772-2	2021	Here, we present the role of TRDMT1 in reactive oxygen species-induced granulosa cells death, which is considered an important cause of premature ovarian failure.	oxygen species	48-62	tRNA aspartic acid methyltransferase 1	Homo sapiens	29-35
34100772-3	2021	We found that reactive oxygen species were increased in a H2O2 dose-dependent manner and accompanied by the nuclear shuttling of TRDMT1, increased DNA damage and increased apoptosis of granulosa cells.	oxygen species	23-37	tRNA aspartic acid methyltransferase 1	Homo sapiens	129-135
34156885-8	2021	Moreover, miR-214 expression level positively correlated with the reactive oxygen species (ROS) level, while it was negatively correlated with mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH) and mean corpuscular Hb concentration (MCHC).	oxygen species	75-89	microRNA 214	Homo sapiens	10-17
35598668-8	2022	The overexpression of the Bcl-2 family genes and the activation of the Fas/FasL pathway triggered downstream caspase cascade and caused reactive oxygen species signaling-mediated apoptosis/necrosis.	oxygen species	145-159	BCL2, apoptosis regulator	Rattus norvegicus	26-31
35598668-8	2022	The overexpression of the Bcl-2 family genes and the activation of the Fas/FasL pathway triggered downstream caspase cascade and caused reactive oxygen species signaling-mediated apoptosis/necrosis.	oxygen species	145-159	Fas ligand	Rattus norvegicus	75-79
34100896-5	2021	Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix, vasculogenesis, and reactive oxygen species metabolism.	oxygen species	166-180	delta 4-desaturase, sphingolipid 1	Homo sapiens	5-9
34082427-1	2021	INTRODUCTION: Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events.	oxygen species	109-123	xanthine dehydrogenase	Homo sapiens	14-37
34082427-1	2021	INTRODUCTION: Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events.	oxygen species	109-123	xanthine dehydrogenase	Homo sapiens	39-42
35446108-0	2022	Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.	oxygen species	93-107	microtubule associated protein tau	Homo sapiens	54-57
35535614-5	2022	In vitro, Poldip2-deficient neutrophils responded as well as wild-type neutrophils to inflammatory stimuli with respect to neutrophil extracellular trap formation, reactive oxygen species production, and induction of cytokines.	oxygen species	173-187	polymerase (DNA-directed), delta interacting protein 2	Mus musculus	10-17
35526561-9	2022	Finally, we demonstrated that Negr1-/- mouse embryonic fibroblasts (MEFs) showed elevated reactive oxygen species levels and decreased adenosine monophosphate-activated protein kinase activation compared with control MEFs.	oxygen species	99-113	neuronal growth regulator 1	Mus musculus	30-35
35629388-1	2022	The mitochondrial uncoupling protein 2 (UCP2) acts as an anion transporter and as an antioxidant factor able to reduce the reactive oxygen species level.	oxygen species	132-146	uncoupling protein 2	Homo sapiens	4-38
35629388-1	2022	The mitochondrial uncoupling protein 2 (UCP2) acts as an anion transporter and as an antioxidant factor able to reduce the reactive oxygen species level.	oxygen species	132-146	uncoupling protein 2	Homo sapiens	40-44
35594815-5	2022	TP53 interacts with the majority of lung disease-related genes and regulates important and commonly occurring biological functions and pathways, including gland development, aging, reactive oxygen species metabolic process, the response to oxygen levels, and fluid shear stress, among others.	oxygen species	190-204	tumor protein p53	Homo sapiens	0-4
35443164-4	2022	Membranous TNF (mTNF) outside-in signaling induces the formation of reactive oxygen species, known activators of NETosis.	oxygen species	77-91	tumor necrosis factor	Homo sapiens	11-14
35468173-1	2022	beta-Amyloid (Abeta) peptides can bind both Cu2+ and heme cofactors simultaneously to form heme-Cu2+-Abeta complexes, which are proposed to generate toxic partially reduced oxygen species (PROS, e.g., H2O2) and play a vital role in Alzheimer"s disease (AD).	oxygen species	173-187	amyloid beta precursor protein	Homo sapiens	14-19
35468173-1	2022	beta-Amyloid (Abeta) peptides can bind both Cu2+ and heme cofactors simultaneously to form heme-Cu2+-Abeta complexes, which are proposed to generate toxic partially reduced oxygen species (PROS, e.g., H2O2) and play a vital role in Alzheimer"s disease (AD).	oxygen species	173-187	amyloid beta precursor protein	Homo sapiens	101-106
35363060-3	2022	NLRX1 has multiple functions, including negative regulation of type-I interferon signaling, attenuation of proinflammatory nuclear factor kappa B (NF-kappaB) signaling, autophagy induction, modulation of reactive oxygen species production, cell death regulation, and participating in cellular senescence.	oxygen species	213-227	NLR family member X1	Homo sapiens	0-5
35143833-3	2022	Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV.	oxygen species	345-359	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
35143833-3	2022	Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV.	oxygen species	345-359	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
35143833-3	2022	Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV.	oxygen species	345-359	VPS41 subunit of HOPS complex	Homo sapiens	119-124
35143833-3	2022	Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV.	oxygen species	345-359	VPS41 subunit of HOPS complex	Homo sapiens	167-172
35143833-3	2022	Here, we found that Nrf2 regulated circular RNA circ-Vps41 to increase hippocampal synaptic plasticity; Nrf2 bound the Vps41 promoter to activate transcription of the Vps41 gene and promote expression of circ-Vps41; circ-Vps41 positively correlated with Nrf2, synaptic plasticity, and learning and memory but negatively correlated with reactive oxygen species; and Nrf2 promoted CaMKIV expression by increasing levels of circ-Vps41, which can absorb miR-26a-5p that targets CaMKIV.	oxygen species	345-359	VPS41 subunit of HOPS complex	Homo sapiens	209-214
35443164-4	2022	Membranous TNF (mTNF) outside-in signaling induces the formation of reactive oxygen species, known activators of NETosis.	oxygen species	77-91	tumor necrosis factor	Mus musculus	16-20
35450409-3	2022	In addition to the direct association between I-R and the release of reactive oxygen species and reactive nitrogen species, it is involved in developing mitochondrial oxidative damage.	oxygen species	78-92	insulin receptor	Homo sapiens	46-49
35437791-6	2022	Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS).	oxygen species	25-39	NLR family pyrin domain containing 3	Homo sapiens	191-196
35399255-8	2022	Furthermore, GJA1-20k localizes to the mitochondrial outer membrane and induces a protective and DRP1 independent form of mitochondrial fission, preserving ATP production and generating less reactive oxygen species (ROS) under metabolic stress, providing powerful protection of myocardium to ischemic insult.	oxygen species	200-214	gap junction protein, alpha 1	Mus musculus	13-17
35464759-4	2022	In the present study, we demonstrated that excessive SLC25A26 accumulation in mouse oocytes mimicked naturally aged oocytes and resulted in lower oocyte quality with decreased maturation rate and increased reactive oxygen species (ROS) by impairing mitochondrial function.	oxygen species	215-229	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26	Mus musculus	53-61
35235349-4	2022	Here, we show that Rps9 D95N knock-in mice exhibit reduced life span and a premature onset of numerous aging-related phenotypes, such as reduced weight, chest deformation, hunchback posture, poor fur condition, and urinary syndrome, together with lymphopenia, increased levels of reactive oxygen species-inflicted damage, accelerated age-related changes in DNA methylation, and telomere attrition.	oxygen species	289-303	ribosomal protein S9	Mus musculus	19-23
35023144-2	2022	This study mainly focuses on the role of the reactive oxygen species-NLR family, pyrin domain-containing 3 (ROS-NLRP3) signaling pathway in SI after thulium laser resection of the prostate (TmLRP).	oxygen species	54-68	NLR family pyrin domain containing 3	Homo sapiens	112-117
35338257-7	2022	Finally, we showed that HSP70 inhibited compression-induced mitochondrial fission by promoting SIRT3 expression, thereby attenuating mitochondrial dysfunction and the production of reactive oxygen species and ultimately inhibiting the mitochondrial apoptotic pathway in NP cells.	oxygen species	190-204	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
35086548-0	2022	Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway.	oxygen species	9-23	microRNA 155	Mus musculus	105-112
35186974-6	2021	Conversely, the HIF-1alpha-mediated protective effect was strengthened by scavenger N-acetylcysteine (NAC), a type of reactive oxygen species.	oxygen species	127-141	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
35086548-0	2022	Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway.	oxygen species	9-23	CD274 antigen	Mus musculus	116-121
35104762-0	2022	Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways.	oxygen species	121-135	peroxiredoxin 2	Mus musculus	106-111
35054935-0	2022	Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells.	oxygen species	124-138	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
35054935-0	2022	Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells.	oxygen species	124-138	mitogen-activated protein kinase 1	Homo sapiens	98-101
34907600-6	2022	We also found that GRIM-19 is required for the generation of mitochondrial reactive oxygen species and NLRP3-dependent activation of caspase-1.	oxygen species	84-98	NADH:ubiquinone oxidoreductase subunit A13	Mus musculus	19-26
34998404-12	2022	Upregulation of HIF-1alpha in 5-FU-resistant CRC occurred through non-oxygen-dependent mechanisms of reactive oxygen species-mediated activation of PI3K/Akt signaling and aberrant activation of beta-catenin in the nucleus.	oxygen species	110-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
34998404-12	2022	Upregulation of HIF-1alpha in 5-FU-resistant CRC occurred through non-oxygen-dependent mechanisms of reactive oxygen species-mediated activation of PI3K/Akt signaling and aberrant activation of beta-catenin in the nucleus.	oxygen species	110-124	AKT serine/threonine kinase 1	Homo sapiens	153-156
33914863-10	2022	During early atherogenesis, SMC-Dbn-/-/Ldlr-/- aortas demonstrated 1.6-fold higher levels of reactive oxygen species than control mouse aortas.	oxygen species	102-116	low density lipoprotein receptor	Mus musculus	39-43
3264366-5	1988	The remarkable in vitro release of neutral proteinases and activated oxygen species from granulocytes after GM-CSF stimulation may be of importance in vivo.	oxygen species	69-83	colony stimulating factor 2	Homo sapiens	108-114
34013361-1	2021	Localization of phosphorylated (p)-JNK to the mitochondria can lead to functional mitochondrial disorder, resulting in a decrease in energy supply and membrane potential, as well as an increase in reactive oxygen species production and apoptosis.	oxygen species	206-220	mitogen-activated protein kinase 8	Homo sapiens	35-38
32800520-2	2021	CBS gene KD in ASC52telo cells led to increased cellular inflammation (IL6, CXCL8, TNF) and oxidative stress markers (increased intracellular reactive oxygen species and decreased reduced glutathione levels) in parallel to decreased H2S production and rejuvenation (LC3 and SIRT1)-related gene expression.	oxygen species	151-165	cystathionine beta-synthase	Homo sapiens	0-3
33420900-8	2021	Upon the addition of Rb1, mitochondrial and intracellular reactive oxygen species generation and malondialdehyde levels were decreased (P<0.01), while the activities of antioxidant enzymes were increased (P<0.05 or P<0.01).	oxygen species	67-81	RB transcriptional corepressor 1	Homo sapiens	21-24
33919154-0	2021	Elevated Interleukin-18 Receptor Accessory Protein Mediates Enhancement in Reactive Oxygen Species Production in Neutrophils of Systemic Lupus Erythematosus Patients.	oxygen species	84-98	interleukin 18 receptor accessory protein	Homo sapiens	9-50
33648469-14	2021	CONCLUSION: Cyclic compressive loading induced mRNA expressions of ADAMTS4 and IL-1R through reactive oxygen species.	oxygen species	102-116	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	67-74
33749882-4	2021	Targeted deletion of Mfn2 gene in myoblasts (Mfn2MKO ) increases oxygen-consumption rates (OCR) associated with the maximal respiration and spare respiratory capacity, and increased levels of reactive oxygen species (ROS).	oxygen species	201-215	mitofusin 2	Mus musculus	21-25
33664298-3	2021	The SNCA-knockout clones in culture exhibited a decrease in the transferrin receptor 1 (TfR1), an increase in ferritin, an increase of reactive oxygen species and proliferated slower than control cells.	oxygen species	144-158	synuclein alpha	Homo sapiens	4-8
33643224-14	2020	Our research indicated that ZmHKT-1 and zmNHX1 expression could effectively enhance salt tolerance by maintaining an optimal Na+/K+ balance and increasing the antioxidant activity that keeps reactive oxygen species at a low accumulation level.	oxygen species	200-214	Cation transporter HKT8-like	Zea mays	28-35
33010069-6	2021	Here, we discovered that the loss of R-Ras1 and/or R-Ras2 function is associated with aberrant myelinated axons with increased numbers of mitochondria, and a disrupted mitochondrial respiration that leads to increased reactive oxygen species levels.	oxygen species	227-241	related RAS viral (r-ras) oncogene 2	Mus musculus	51-57
33450674-1	2021	Human Islet Amyloid Polypeptide (hIAPP) or amylin, can bind heme and the resultant complexes are prone to generate partially reduced oxygen species (PROS).	oxygen species	133-147	islet amyloid polypeptide	Homo sapiens	33-38
33620659-10	2021	G6PD status is extremely important in modulating the level of reactive oxygen species and many cellular immune responses such as enhanced production of the pro-inflammatory cytokine and inflammasome activation.	oxygen species	71-85	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
33174606-5	2021	Utx expression in HSCs declines with age and UtxDelta/Delta HSPCs exhibited increased expression of an aging-associated marker, accumulation of reactive oxygen species, and impaired repair of DNA double-strand breaks.	oxygen species	153-167	lysine (K)-specific demethylase 6A	Mus musculus	0-3
33448309-5	2021	Several genes involved in a number of cellular processes, such as the cell cycle, proliferation, growth, migration and differentiation, as well as in apoptosis, reactive oxygen species generation, chemotaxis and immune responses, were differentially expressed in the EGFL8-overexpressing or -silenced cTECs.	oxygen species	170-184	EGF-like domain 8	Mus musculus	267-272
33452125-5	2021	In contrast, HRG maintained the responsiveness of neutrophils to TNF-alpha, zymosan, and E. coli with regard to reactive oxygen species production.	oxygen species	121-135	histidine rich glycoprotein	Homo sapiens	13-16
33545428-9	2021	The consequent liver damage arises from mitochondrial reactive oxygen species production and results in hepatic dysfunction in protein output, complement, coagulation, iron homeostasis, and IGF-1 metabolism.	oxygen species	63-77	insulin-like growth factor 1	Mus musculus	190-195
33297749-9	2021	Finally, the NFU1 mutation produced a dysregulated antioxidant system in the mitochondria, leading to increased reactive oxygen species levels.	oxygen species	121-135	NFU1 iron-sulfur cluster scaffold	Rattus norvegicus	13-17
33225593-6	2021	Given many atrophic triggers (e.g. ubiquitin proteasome/autophagy/calpain activity and supressed IGF1-Akt-mTORC1 signalling) are linked to increased production of reactive oxygen species, we speculate that a higher pro-oxidative state in HFDM could be a unifying mechanism that promotes accelerated fibre atrophy.	oxygen species	172-186	CREB regulated transcription coactivator 1	Mus musculus	106-112
33336494-3	2021	An increase in oxidative stress is correlated with inflammation and intense research was developed to understand the interaction between inflammation and adiponectin, based on the fact that many adipokines are inflammation related proteins linked to reactive oxygen species production.	oxygen species	259-273	adiponectin, C1Q and collagen domain containing	Homo sapiens	154-165
33225593-6	2021	Given many atrophic triggers (e.g. ubiquitin proteasome/autophagy/calpain activity and supressed IGF1-Akt-mTORC1 signalling) are linked to increased production of reactive oxygen species, we speculate that a higher pro-oxidative state in HFDM could be a unifying mechanism that promotes accelerated fibre atrophy.	oxygen species	172-186	insulin like growth factor 1	Homo sapiens	97-101
33225593-6	2021	Given many atrophic triggers (e.g. ubiquitin proteasome/autophagy/calpain activity and supressed IGF1-Akt-mTORC1 signalling) are linked to increased production of reactive oxygen species, we speculate that a higher pro-oxidative state in HFDM could be a unifying mechanism that promotes accelerated fibre atrophy.	oxygen species	172-186	AKT serine/threonine kinase 1	Homo sapiens	102-105
32918333-5	2021	Overexpression of PARK7 effectively reduced reactive oxygen species and malondialdehyde, protected mitochondrial membrane potential, and resisted oxidative-stress-induced apoptosis of BMSCs, but the expression of PARK7 was downregulated, these results were reversed.	oxygen species	53-67	Parkinsonism associated deglycase	Homo sapiens	18-23
33598426-9	2020	Additionally, CISD2 knockdown accelerated the accumulation of cellular and mitochondrial reactive oxygen species, destroying the mitochondrial morphology and function.	oxygen species	98-112	CDGSH iron sulfur domain 2	Homo sapiens	14-19
33025669-7	2021	Furthermore, the inhibition of Mps1 activity resulted in an increase of DNA damage, which further induced oxidative stress, showing with positive gamma-H2A.X signal and increased reactive oxygen species level.	oxygen species	188-202	Ttk protein kinase	Mus musculus	31-35
33585431-5	2021	Methods: We synthesize and assemble a hydrogen peroxide [H2O2, belongs to the category of active oxygen species (ROS)]-sensitive nanomicelle, which is loaded with the anti-inflammation drug dexamethasone and chondrogenic differentiation factor cartilage-derivedmor-phogeneticprotein-1.	oxygen species	97-111	growth differentiation factor 5	Homo sapiens	244-284
33462325-6	2021	Improvement in the survival of the neurons and the outgrowth of neurites was achieved in the neurons transfected by LV-CGRP or by exogenous CGRP, paralleling the correction of abnormalities of intracellular reactive oxygen species and mitochondrial transmembrane potentials.	oxygen species	216-230	calcitonin-related polypeptide alpha	Rattus norvegicus	140-144
33246403-4	2020	RESULTS: Antioxidant enzymes including, catalase (CAT), peroxidase (POD), superoxide dismutase (SOD) were found significantly induced under temporal salt stress, suggesting that reactive oxygen species scavenging antioxidant machinery is an essential component of salt tolerance mechanism in cotton.	oxygen species	187-201	catalase isozyme 1-like	Gossypium hirsutum	40-48
33441125-2	2021	TNF-alpha activates inflammatory response through a cascade of immune responses, augmenting pro-inflammatory mediators and proteases, activating chemotaxis, and infiltration of inflammatory cells, leading to ulceration and haemorrhage through cytotoxic reactive oxygen species.	oxygen species	262-276	tumor necrosis factor	Rattus norvegicus	0-9
33597876-5	2020	Alda-1 [(N-(1, 3 benzodioxol-5-ylmethyl)-2, 6- dichloro-benzamide)], a small molecular activator of ALDH2, protects against reactive oxygen species-mediated oxidative stress by promoting ALDH2 activity.	oxygen species	133-147	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	100-105
33437352-5	2020	Dysfunction of AMPK activity has been associated with reduced autophagy, impaired mitochondrial function, excessive reactive oxygen species generation, and inflammation in joint tissue.	oxygen species	125-139	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	15-19
33488493-8	2020	Tau aggregates have also been shown to induce mitochondrial damage: it is known that tau impairs mitochondrial localization, distribution and dynamics, alters ATP and reactive oxygen species production, and compromises oxidative phosphorylation systems.	oxygen species	176-190	microtubule associated protein tau	Homo sapiens	0-3
33488493-8	2020	Tau aggregates have also been shown to induce mitochondrial damage: it is known that tau impairs mitochondrial localization, distribution and dynamics, alters ATP and reactive oxygen species production, and compromises oxidative phosphorylation systems.	oxygen species	176-190	microtubule associated protein tau	Homo sapiens	85-88
33091478-4	2021	This FU-Ppy NP proved to be an excellent P-selectin-mediated, lung cancer-cell/tumor targeting delivery and specific accumulation, could augment cancer/tumor oxidative stress levels through producing cellular reactive oxygen species.	oxygen species	218-232	selectin P	Homo sapiens	41-51
33374660-5	2020	Regarding the molecular mechanisms of mitochondrial-mediated necroptosis, the RIPK1/RIPK3/MLKL necrosome complex can enhance oxidative respiration and generate reactive oxygen species, which can be a crucial factor in the susceptibility of cells to necroptosis.	oxygen species	169-183	receptor interacting serine/threonine kinase 1	Homo sapiens	78-83
33374660-5	2020	Regarding the molecular mechanisms of mitochondrial-mediated necroptosis, the RIPK1/RIPK3/MLKL necrosome complex can enhance oxidative respiration and generate reactive oxygen species, which can be a crucial factor in the susceptibility of cells to necroptosis.	oxygen species	169-183	receptor interacting serine/threonine kinase 3	Homo sapiens	84-89
33374660-5	2020	Regarding the molecular mechanisms of mitochondrial-mediated necroptosis, the RIPK1/RIPK3/MLKL necrosome complex can enhance oxidative respiration and generate reactive oxygen species, which can be a crucial factor in the susceptibility of cells to necroptosis.	oxygen species	169-183	mixed lineage kinase domain like pseudokinase	Homo sapiens	90-94
32931837-3	2020	Recently detected mutations in the mtND1 can disrupt the normal activity of complex I and affect oxidative phosphorylation, thus leading to increase reactive oxygen species production.	oxygen species	158-172	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	35-40
32743653-11	2020	CONCLUSION: Our data revealed that decreased ATM activation in monocytes was associated with SSc-interstitial lung disease and that impaired ATM activation in monocytes may contribute to the disease process of SSc via uncontrolled reactive oxygen species production.	oxygen species	240-254	ATM serine/threonine kinase	Homo sapiens	141-144
33246403-4	2020	RESULTS: Antioxidant enzymes including, catalase (CAT), peroxidase (POD), superoxide dismutase (SOD) were found significantly induced under temporal salt stress, suggesting that reactive oxygen species scavenging antioxidant machinery is an essential component of salt tolerance mechanism in cotton.	oxygen species	187-201	peroxidase 42-like	Gossypium hirsutum	56-66
33079558-9	2020	It was also noteworthy the activation of caspase-9 was correlated with the continuous overproduction of reactive oxygen species up to a 48 h time point after the treatment of PmAb-TMZ-PLGA-NPs.	oxygen species	113-127	caspase 9	Homo sapiens	41-50
33218188-0	2020	CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer.	oxygen species	41-55	carnitine palmitoyltransferase 1A	Homo sapiens	0-5
33145450-6	2020	High, but not low cyanidin was shown to induce Yap1 translocation from cytosol to nucleus, probably by generating reactive oxygen species such as H2O2.	oxygen species	123-137	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	47-51
33313244-7	2020	Compared with the ET-1 + NC group, the levels of reaction oxygen species (ROS) in the ET-1 + ERbeta siRNA group increased considerably, the superoxide dismutase (SOD) level was significantly reduced, and the G0/G1 phase cell ratio was reduced.	oxygen species	58-72	endothelin 1	Homo sapiens	18-22
33313244-7	2020	Compared with the ET-1 + NC group, the levels of reaction oxygen species (ROS) in the ET-1 + ERbeta siRNA group increased considerably, the superoxide dismutase (SOD) level was significantly reduced, and the G0/G1 phase cell ratio was reduced.	oxygen species	58-72	endothelin 1	Homo sapiens	86-90
33313244-7	2020	Compared with the ET-1 + NC group, the levels of reaction oxygen species (ROS) in the ET-1 + ERbeta siRNA group increased considerably, the superoxide dismutase (SOD) level was significantly reduced, and the G0/G1 phase cell ratio was reduced.	oxygen species	58-72	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	93-99
32738398-0	2020	Generation of sphingosine-1-phosphate by sphingosine kinase 1 protects nonalcoholic fatty liver from ischemia/reperfusion injury through alleviating reactive oxygen species production in hepatocytes.	oxygen species	158-172	sphingosine kinase 1	Mus musculus	41-61
33122517-5	2020	Mechanistically, NGAL significantly reduced the levels of reactive oxygen species and 4HNE adduct formation in a 24p3R-dependent manner and upregulated the expression of acinar cell regeneration markers, like CDK-2, CDK-4, and C-myc.	oxygen species	67-81	lipocalin 2	Mus musculus	17-21
33082328-4	2020	The studies in vitro confirmed the specificity of ZHER2:2395-IR700 binding to HER2-positive cells and its ability to produce reactive oxygen species upon light irradiation.	oxygen species	134-148	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
33028529-4	2020	Mechanistically, OGD triggered a burst in reactive oxygen species that induced both DSBs and translocation of WRAP53 to the nucleus to promote DNA repair, a pathway that was confirmed in an in vivo mouse model of stroke.	oxygen species	51-65	WD repeat containing, antisense to Trp53	Mus musculus	110-116
33081406-6	2020	With primary cultured PTEC from Spp1-enhanced green fluorescent protein knock-in mice, we proved that in high-glucose conditions, increased SGLT2- and GLUT-mediated glucose uptake is causatively involved in aberrant activation of the glycolytic pathway in PTEC, thereby increasing mitochondrial reactive oxygen species (ROS) formation and transcriptional activation of Spp1.	oxygen species	304-318	secreted phosphoprotein 1	Mus musculus	32-36
33081406-6	2020	With primary cultured PTEC from Spp1-enhanced green fluorescent protein knock-in mice, we proved that in high-glucose conditions, increased SGLT2- and GLUT-mediated glucose uptake is causatively involved in aberrant activation of the glycolytic pathway in PTEC, thereby increasing mitochondrial reactive oxygen species (ROS) formation and transcriptional activation of Spp1.	oxygen species	304-318	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	140-145
33081406-6	2020	With primary cultured PTEC from Spp1-enhanced green fluorescent protein knock-in mice, we proved that in high-glucose conditions, increased SGLT2- and GLUT-mediated glucose uptake is causatively involved in aberrant activation of the glycolytic pathway in PTEC, thereby increasing mitochondrial reactive oxygen species (ROS) formation and transcriptional activation of Spp1.	oxygen species	304-318	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	151-155
32825452-4	2020	We show that WIP depletion increases the levels of reactive oxygen species and reduces the levels of transcription factor NRF2, the master regulator of redox homeostasis.	oxygen species	60-74	WAS/WASL interacting protein family member 1	Homo sapiens	13-16
32940033-5	2020	Importantly, activated AMPK alleviates mitochondrial disorder via the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha)-nuclear transcription factor 1 (NRF-1)-mitochondrial transcription factor A (TFAM) pathway, then reduces reactive oxygen species production, and blocks the activation of p38 MAPK-NF-kappaB pathway in OA-induced hepatocytes.	oxygen species	265-279	PPARG coactivator 1 alpha	Gallus gallus	70-137
32940033-5	2020	Importantly, activated AMPK alleviates mitochondrial disorder via the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha)-nuclear transcription factor 1 (NRF-1)-mitochondrial transcription factor A (TFAM) pathway, then reduces reactive oxygen species production, and blocks the activation of p38 MAPK-NF-kappaB pathway in OA-induced hepatocytes.	oxygen species	265-279	nuclear respiratory factor 1	Gallus gallus	183-188
32940033-5	2020	Importantly, activated AMPK alleviates mitochondrial disorder via the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha)-nuclear transcription factor 1 (NRF-1)-mitochondrial transcription factor A (TFAM) pathway, then reduces reactive oxygen species production, and blocks the activation of p38 MAPK-NF-kappaB pathway in OA-induced hepatocytes.	oxygen species	265-279	transcription factor A, mitochondrial	Gallus gallus	228-232
32279354-10	2020	Finally, we found that zr17-2, a CIRBP agonist, could enhance the expression of CIRBP, which further enhances the synthesis of CoQ10 and promotes scavenge of reactive oxygen species and ATP production to extend the heart preservation.	oxygen species	167-181	cold inducible RNA binding protein	Rattus norvegicus	33-38
32279354-10	2020	Finally, we found that zr17-2, a CIRBP agonist, could enhance the expression of CIRBP, which further enhances the synthesis of CoQ10 and promotes scavenge of reactive oxygen species and ATP production to extend the heart preservation.	oxygen species	167-181	cold inducible RNA binding protein	Rattus norvegicus	80-85
32710395-3	2020	PRODH/POX catalyzes conversion of proline into Delta1-pyrroline-5-carboxylate releasing ATP or reactive oxygen species for autophagy/apoptosis.	oxygen species	104-118	proline dehydrogenase 1	Homo sapiens	0-5
32993092-6	2020	of Abeta (3 microL/5 min/mouse) into the brain of a mouse increased the reactive oxygen species (ROS) levels, neuroinflammation, and memory and cognitive dysfunction.	oxygen species	81-95	amyloid beta (A4) precursor protein	Mus musculus	3-8
32958140-5	2020	We show that WDR26-mediated inhibition of wound repair is mediated through the inhibition of Rac family small GTPase 1 and cell division cycle 42 activation, as well as downstream intracellular reactive oxygen species production.	oxygen species	203-217	WD repeat domain 26	Homo sapiens	13-18
32693110-0	2020	The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.	oxygen species	99-113	PTK2 protein tyrosine kinase 2 beta	Mus musculus	33-37
32726690-6	2020	Flies mutant for the DJ-1beta gene, the Drosophila ortholog of human DJ-1, exhibited disease-related phenotypes such as motor defects, increased reactive oxygen species production and high levels of protein carbonylation.	oxygen species	154-168	DJ-1alpha	Drosophila melanogaster	21-29
32726690-6	2020	Flies mutant for the DJ-1beta gene, the Drosophila ortholog of human DJ-1, exhibited disease-related phenotypes such as motor defects, increased reactive oxygen species production and high levels of protein carbonylation.	oxygen species	154-168	Parkinsonism associated deglycase	Homo sapiens	21-25
32619679-14	2020	Furthermore, data from treatment of reactive oxygen species inhibitor N-acetyl-L-cysteine or NOXs inhibitor diphenyleneiodonium in fructose-exposed HepG2 cells showed that fructose enhanced NOX1, NOX2 and NOX4 expression to increase reactive oxygen species generation, causing oxidative stress and inflammation, more importantly, these disturbances were significantly attenuated by magnesium isoglycyrrhizinate.	oxygen species	45-59	NADPH oxidase 1	Homo sapiens	190-194
32554304-6	2020	Depletion or inhibition of RAD51 results in G2/M arrest, increased production of reactive oxygen species and accumulation of oxidative DNA damage.	oxygen species	90-104	RAD51 recombinase	Homo sapiens	27-32
32582195-6	2020	A mechanistic study revealed that S. sonnei induced IL-1beta production through P2X7 receptor-mediated potassium efflux, reactive oxygen species generation, lysosomal acidification, and mitochondrial damage.	oxygen species	130-144	interleukin 1 alpha	Homo sapiens	52-60
32831473-6	2020	The resulting nanostructured surface exhibits extreme bactericidal effectiveness (9250 cells cm-2 h-1) that eliminates bacteria in direct contact and also remotely through the action of reactive oxygen species.	oxygen species	195-209	H1.5 linker histone, cluster member	Homo sapiens	98-101
32458504-8	2020	Our functional analysis showed that exogenously induced MIEAP, but not PARK2, reduced the amounts of abnormal mitochondria, as indicated by decreased reactive oxygen species levels, mitochondrial DNA / nuclear DNA ratios, and cytoplasmic acidification.	oxygen species	159-173	spermatogenesis associated 18	Homo sapiens	56-61
31593983-10	2020	In addition, enforced expression of EVI1 also increased intracellular reactive oxygen species and ATG7 mRNA levels as well as autophagy activity, whereas the increase was attenuated after treatment with reactive oxygen species scavenger, suggesting the involvement of reactive oxygen species in EVI1-induced autophagy.	oxygen species	79-93	MDS1 and EVI1 complex locus	Homo sapiens	36-40
32801466-3	2020	Activation of AhR promotes generation of intracellular reactive oxygen species (ROS) and inflammation.	oxygen species	64-78	aryl hydrocarbon receptor	Homo sapiens	14-17
32849878-7	2020	Independent on the accumulation of DXR, lower level of reactive oxygen species and higher expression of Nrf2 were detected in CD44+CD133+ than CD44+CD133- cells (P < 0.05).	oxygen species	64-78	CD44 molecule (Indian blood group)	Homo sapiens	126-130
32849878-7	2020	Independent on the accumulation of DXR, lower level of reactive oxygen species and higher expression of Nrf2 were detected in CD44+CD133+ than CD44+CD133- cells (P < 0.05).	oxygen species	64-78	prominin 1	Homo sapiens	131-136
32849878-7	2020	Independent on the accumulation of DXR, lower level of reactive oxygen species and higher expression of Nrf2 were detected in CD44+CD133+ than CD44+CD133- cells (P < 0.05).	oxygen species	64-78	CD44 molecule (Indian blood group)	Homo sapiens	143-147
32849878-7	2020	Independent on the accumulation of DXR, lower level of reactive oxygen species and higher expression of Nrf2 were detected in CD44+CD133+ than CD44+CD133- cells (P < 0.05).	oxygen species	64-78	prominin 1	Homo sapiens	148-153
32923988-7	2020	Through generation of inducible skeletal muscle-specific Tak1-knockout mice, we demonstrate that targeted ablation of TAK1 disrupts redox signaling leading to the accumulation of reactive oxygen species and loss of skeletal muscle mass and contractile function.	oxygen species	188-202	mitogen-activated protein kinase kinase kinase 7	Mus musculus	57-61
32923988-7	2020	Through generation of inducible skeletal muscle-specific Tak1-knockout mice, we demonstrate that targeted ablation of TAK1 disrupts redox signaling leading to the accumulation of reactive oxygen species and loss of skeletal muscle mass and contractile function.	oxygen species	188-202	mitogen-activated protein kinase kinase kinase 7	Mus musculus	118-122
32832750-5	2020	Particularly, alpha-MG significantly suppressed the overproduction of reactive oxygen species (ROS), restored the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), and downregulated the c-JUN N-terminal kinase (JNK) pathways following cisplatin challenge.	oxygen species	79-93	amelogenin X-linked	Homo sapiens	14-22
32351032-5	2020	In murine erythroleukemic (MEL) cells in vitro, ligand-mediated overactivation of the Smad2/3 pathway reduced nuclear levels of GATA-1 (GATA-binding factor-1) and its transcriptional activator TIF1gamma (transcription intermediary factor 1gamma), increased levels of reactive oxygen species, reduced cell viability and haemoglobin levels, and inhibited erythroid differentiation.	oxygen species	276-290	SMAD family member 2	Mus musculus	86-93
32351032-5	2020	In murine erythroleukemic (MEL) cells in vitro, ligand-mediated overactivation of the Smad2/3 pathway reduced nuclear levels of GATA-1 (GATA-binding factor-1) and its transcriptional activator TIF1gamma (transcription intermediary factor 1gamma), increased levels of reactive oxygen species, reduced cell viability and haemoglobin levels, and inhibited erythroid differentiation.	oxygen species	276-290	GATA binding protein 1	Mus musculus	128-134
32351032-5	2020	In murine erythroleukemic (MEL) cells in vitro, ligand-mediated overactivation of the Smad2/3 pathway reduced nuclear levels of GATA-1 (GATA-binding factor-1) and its transcriptional activator TIF1gamma (transcription intermediary factor 1gamma), increased levels of reactive oxygen species, reduced cell viability and haemoglobin levels, and inhibited erythroid differentiation.	oxygen species	276-290	GATA binding protein 1	Mus musculus	136-157
32060267-5	2020	Elevated MYCN levels promote metabolic reprogramming, mitochondrial dysfunction, reactive-oxygen species generation, and DNA-replicative stress.	oxygen species	90-104	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	9-13
32293198-5	2020	eHSP70 can activate NFkappaB and activator protein-1, thus stimulating the release of inflammatory cytokines and production of reactive oxygen species.	oxygen species	136-150	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-52
32069075-3	2020	We found that the combined action of the Notch1 and Keap1-Nrf2 signaling pathways significantly increased cardiomyocyte viability, inhibited cardiomyocyte apoptosis, reduced the formation of reactive oxygen species, and increased antioxidant activities.	oxygen species	200-214	notch receptor 1	Rattus norvegicus	41-47
32069075-3	2020	We found that the combined action of the Notch1 and Keap1-Nrf2 signaling pathways significantly increased cardiomyocyte viability, inhibited cardiomyocyte apoptosis, reduced the formation of reactive oxygen species, and increased antioxidant activities.	oxygen species	200-214	Kelch-like ECH-associated protein 1	Rattus norvegicus	52-57
32069075-3	2020	We found that the combined action of the Notch1 and Keap1-Nrf2 signaling pathways significantly increased cardiomyocyte viability, inhibited cardiomyocyte apoptosis, reduced the formation of reactive oxygen species, and increased antioxidant activities.	oxygen species	200-214	NFE2 like bZIP transcription factor 2	Rattus norvegicus	58-62
32192225-0	2020	Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.	oxygen species	128-142	sphingosine kinase 1	Mus musculus	0-20
32192225-0	2020	Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.	oxygen species	128-142	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
32066826-0	2020	miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy.	oxygen species	85-99	microRNA 27a	Homo sapiens	0-7
32457638-8	2020	Additionally, PD gene products, including DJ-1, SNCA, UCH-L1, PINK-1, and Parkin, also interfere with mitochondrial function leading to reactive oxygen species production and dopaminergic neuronal vulnerability to oxidative stress.	oxygen species	145-159	Parkinsonism associated deglycase	Homo sapiens	42-46
32457638-8	2020	Additionally, PD gene products, including DJ-1, SNCA, UCH-L1, PINK-1, and Parkin, also interfere with mitochondrial function leading to reactive oxygen species production and dopaminergic neuronal vulnerability to oxidative stress.	oxygen species	145-159	synuclein alpha	Homo sapiens	48-52
32457638-8	2020	Additionally, PD gene products, including DJ-1, SNCA, UCH-L1, PINK-1, and Parkin, also interfere with mitochondrial function leading to reactive oxygen species production and dopaminergic neuronal vulnerability to oxidative stress.	oxygen species	145-159	ubiquitin C-terminal hydrolase L1	Homo sapiens	54-60
32457638-8	2020	Additionally, PD gene products, including DJ-1, SNCA, UCH-L1, PINK-1, and Parkin, also interfere with mitochondrial function leading to reactive oxygen species production and dopaminergic neuronal vulnerability to oxidative stress.	oxygen species	145-159	PTEN induced kinase 1	Homo sapiens	62-68
32179630-4	2020	When subjected to Cd stress, a dcd mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing DCD had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants.	oxygen species	75-89	D-cysteine desulfhydrase	Arabidopsis thaliana	31-34
32179630-4	2020	When subjected to Cd stress, a dcd mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing DCD had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants.	oxygen species	201-215	D-cysteine desulfhydrase	Arabidopsis thaliana	167-170
31715231-4	2020	To this end, here, the effect of CALB-3 was tested against hypoxia/reoxygenation-induced oxidative stress, antioxidant enzyme and reactive oxygen species levels, and apoptosis-related protein expression in H9c2 cells.	oxygen species	139-153	S100 calcium binding protein G	Rattus norvegicus	33-39
31585863-1	2020	Parkinson"s disease is considered to be due to an increase in the catabolism of dopamine by the action of monoamine oxidase (MAO) enzymes which leads to an increase in reactive oxygen species (ROS) and loss of dopaminergic neurons.	oxygen species	177-191	monoamine oxidase A	Rattus norvegicus	106-123
32024182-8	2020	The relative oxygen species (ROS) significantly increased in cells with inhibited PTP4A3, while the rise was inferior to the control cells at the 20 muM 1,4-BQ group.	oxygen species	13-27	protein tyrosine phosphatase 4A3	Homo sapiens	82-88
31654556-3	2020	PINK1 overexpression mice significantly improved mitochondrial function by increased mitochondrial complex I, II, and III activities and ATP levels with concomitant decline in reactive oxygen species levels.	oxygen species	185-199	PTEN induced putative kinase 1	Mus musculus	0-5
31585863-1	2020	Parkinson"s disease is considered to be due to an increase in the catabolism of dopamine by the action of monoamine oxidase (MAO) enzymes which leads to an increase in reactive oxygen species (ROS) and loss of dopaminergic neurons.	oxygen species	177-191	monoamine oxidase A	Rattus norvegicus	125-128
31656096-7	2019	Remarkably, chronic and acute leptin supplementation restored endothelial function via a PPARgamma-dependent mechanism that decreased Nox1 expression and reactive oxygen species production.	oxygen species	163-177	leptin	Mus musculus	30-36
31618620-12	2019	Increased reactive oxygen species was an important associated mechanism, which inhibited mitochondrial function by affecting VDAC1 expression and function.	oxygen species	19-33	voltage-dependent anion channel 1	Rattus norvegicus	125-130
31656096-7	2019	Remarkably, chronic and acute leptin supplementation restored endothelial function via a PPARgamma-dependent mechanism that decreased Nox1 expression and reactive oxygen species production.	oxygen species	163-177	peroxisome proliferator activated receptor gamma	Mus musculus	89-98
31654751-6	2019	It was also found that blocking PI3K/AKT pathway by LY294002, abolished the protection of H2S against scratch-induced cellular reactive oxygen species level and NRF2 accumulation and function in the nucleus.	oxygen species	136-150	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
30943046-5	2019	Importantly, hvcn1-deficiency significantly reduced reactive oxygen species production and calcium response of zebrafish neutrophils, comparable to the results observed in mammalian models.	oxygen species	61-75	hydrogen voltage-gated channel 1	Danio rerio	13-18
31173361-6	2019	The molecular investigation found that Sirt3 overexpression attenuated IR-induced mitochondrial damage in renal tubular epithelial cells, as evidenced by decreased reactive oxygen species production, increased antioxidants sustained mitochondrial membrane potential, and inactivated mitochondria-initiated death signaling.	oxygen species	173-187	sirtuin 3	Homo sapiens	39-44
31661494-5	2019	The results revealed that, the supplementation of EGF or HA from zygote to the blastocysts stage reduced the level of reactive oxygen species and increased hatching rate after thawing.	oxygen species	127-141	LOC521832	Bos taurus	50-53
28668382-3	2019	Cytokines, particularly tumor necrosis factor-alpha, impede mitochondrial oxidative phosphorylation and associated ATP production and instigate mitochondrial reactive oxygen species production.	oxygen species	167-181	tumor necrosis factor	Homo sapiens	24-51
31302408-14	2019	Nrf2 short-term pharmacological activation attenuates age-related impairment of endothelium-dependent and reactive oxygen species (ROS)-induced vasodilation in different rat and human vascular territories by upregulation of Nrf2-related signaling and decreased oxidative stress.	oxygen species	115-129	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
31302408-14	2019	Nrf2 short-term pharmacological activation attenuates age-related impairment of endothelium-dependent and reactive oxygen species (ROS)-induced vasodilation in different rat and human vascular territories by upregulation of Nrf2-related signaling and decreased oxidative stress.	oxygen species	115-129	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
31406142-6	2019	Silencing of SPANXB1 reduced migration, invasion and reactive oxygen species production of TNBC cells.	oxygen species	62-76	SPANX family member B1	Homo sapiens	13-20
31127489-9	2019	Moreover, inhibition of LRRC8A suppressed AngII-induced PI3K/AKT activation and reactive oxygen species generation, but had no effect on JNK, ERK, and p38 phosphorylation.	oxygen species	89-103	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	24-30
31127489-9	2019	Moreover, inhibition of LRRC8A suppressed AngII-induced PI3K/AKT activation and reactive oxygen species generation, but had no effect on JNK, ERK, and p38 phosphorylation.	oxygen species	89-103	angiotensinogen	Homo sapiens	42-47
31556968-2	2019	Here, we reported that inhibition of MALT1 protease in ABC-DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate.	oxygen species	137-151	MALT1 paracaspase	Homo sapiens	37-51
31556968-2	2019	Here, we reported that inhibition of MALT1 protease in ABC-DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced oxygen consumption rate.	oxygen species	137-151	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	55-58
31597687-6	2019	Analysis of phosphatidic acid (PA), hydrogen peroxide, and jasmonic acid (JA) levels and expression of related genes indicated that the relocalization of PLDdelta is crucial for its activation to produce PA and initiate reactive oxygen species and JA signaling pathways.	oxygen species	229-243	phospholipase D delta	Arabidopsis thaliana	154-162
31678001-0	2019	Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury.	oxygen species	53-67	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	0-20
31092480-8	2019	Mechanistically, AGGF1 activates AKT, reduces nuclear localization of Fyn, which increases the nuclear level of Nrf2 and expression of antioxidative genes, and inhibits reactive oxygen species generation.	oxygen species	178-192	angiogenic factor with G patch and FHA domains 1	Mus musculus	17-22
31315052-1	2019	The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.	oxygen species	115-129	kelch-like ECH-associated protein 1	Mus musculus	4-9
31315052-1	2019	The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.	oxygen species	115-129	nuclear factor, erythroid derived 2, like 2	Mus musculus	10-14
31315052-1	2019	The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.	oxygen species	115-129	kelch-like ECH-associated protein 1	Mus musculus	144-149
31266058-12	2019	In addition, we found that DDIT4 knockdown significantly suppressed the expression of LC3-II and SQSTM1 by disrupting reactive oxygen species release and restoring mitochondrial function under hyperosmolarity.	oxygen species	127-141	DNA damage inducible transcript 4	Homo sapiens	27-32
31266058-12	2019	In addition, we found that DDIT4 knockdown significantly suppressed the expression of LC3-II and SQSTM1 by disrupting reactive oxygen species release and restoring mitochondrial function under hyperosmolarity.	oxygen species	127-141	sequestosome 1	Homo sapiens	97-103
30317629-6	2019	LncRNA 74.1 promoted reactive oxygen species defense by activating prosurvival autophagy then decreased ECM-related proteins fibronectin and collagen I involved in renal fibrosis.	oxygen species	30-44	fibronectin 1	Mus musculus	125-136
30974102-3	2019	We recently found that astrocytes expressing familial ALS-linked SOD1 mutations regulate expression levels of P-gp in endothelial cells, which also exhibit a concomitant, significant increase in reactive oxygen species production and NFkappaB nuclear translocation when exposed to mutant SOD1 astrocyte conditioned media.	oxygen species	204-218	superoxide dismutase 1	Homo sapiens	65-69
30974102-3	2019	We recently found that astrocytes expressing familial ALS-linked SOD1 mutations regulate expression levels of P-gp in endothelial cells, which also exhibit a concomitant, significant increase in reactive oxygen species production and NFkappaB nuclear translocation when exposed to mutant SOD1 astrocyte conditioned media.	oxygen species	204-218	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
30776074-4	2019	The overexpression of FSH3 in WT yeast cells caused an apoptotic phenotype, including accumulation of reaction oxygen species, decreased cell viability and cell death.	oxygen species	111-125	putative serine hydrolase	Saccharomyces cerevisiae S288C	22-26
30875426-7	2019	The acetylcholinesterase inhibitors also decreased vascular reactive oxygen species levels.	oxygen species	69-83	acetylcholinesterase	Rattus norvegicus	4-24
30849487-0	2019	A comprehensive study on the generation of reactive oxygen species in Cu-Abeta-catalyzed redox processes.	oxygen species	52-66	amyloid beta precursor protein	Homo sapiens	73-78
30753668-2	2019	The Target of Rapamycin (TOR) network is a major control mechanism in eukaryotes and influences processes such as translation, mitochondrial activity, production of reactive oxygen species, and the cytoskeleton.	oxygen species	174-188	target of rapamycin	Arabidopsis thaliana	4-23
30996144-6	2019	Although eAT exhibited a depot-specific upregulation in the immune-related pathways relative to mAT and sAT, high UCP1 expression in eAT was specifically associated with differential gene expression that functionally corresponded with downregulation in the production of reactive oxygen species and immune responses, including T cell homeostasis.	oxygen species	280-294	uncoupling protein 1	Homo sapiens	114-118
30753668-2	2019	The Target of Rapamycin (TOR) network is a major control mechanism in eukaryotes and influences processes such as translation, mitochondrial activity, production of reactive oxygen species, and the cytoskeleton.	oxygen species	174-188	target of rapamycin	Arabidopsis thaliana	25-28
30944389-6	2019	A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1beta precursor by reducing reactive oxygen species generation and NF-kappaB activation in lipopolysaccharide-activated macrophages.	oxygen species	117-131	NLR family pyrin domain containing 3	Homo sapiens	67-72
30944389-6	2019	A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1beta precursor by reducing reactive oxygen species generation and NF-kappaB activation in lipopolysaccharide-activated macrophages.	oxygen species	117-131	interleukin 1 alpha	Homo sapiens	77-85
30949411-9	2019	Moreover, chidamide decreased the production of reaction oxygen species (ROS) via SDHA.	oxygen species	57-71	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	82-86
30670444-5	2019	Furthermore, somatic gene mutations of varied functional classes license the NLRP3 inflammasome to generate a common phenotype with excess reactive oxygen species generation, Wnt/beta-catenin-induced proliferation, cation flux-induced cell swelling, and caspase-1 activation.	oxygen species	148-162	NLR family pyrin domain containing 3	Homo sapiens	77-82
30403164-8	2019	Flow cytometry analysis revealed that STAT1 deficiency drives an alternatively activated macrophage phenotype, which is associated with downregulated cluster of differentiation 80 expression, decreased intracellular reactive oxygen species production, and enhanced ability for phagocytosis.	oxygen species	225-239	signal transducer and activator of transcription 1	Mus musculus	38-43
30165404-5	2019	TNF-alpha, generated either in small vessels or within the perivascular adipose tissue (PVAT) of patients with obesity, stimulates reactive oxygen species generation, mainly through NAD(P)H oxidase activation, which in turn reduces nitric oxide (NO) availability.	oxygen species	140-154	tumor necrosis factor	Homo sapiens	0-9
30622235-10	2019	Ectopic expression of HACE1 markedly inhibited anchorage-independent growth and cell motility of HACE1 osteosarcoma cell lines, and was associated with reduced RAC1 activation and decreased reactive oxygen species (ROS).	oxygen species	199-213	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Homo sapiens	22-27
30007118-0	2018	Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.	oxygen species	115-129	Rac family small GTPase 1	Mus musculus	29-33
31021696-2	2019	In the present study, defense priming induced by sodium chloride at the seedling stage significantly increased the expression of defense gene VSP2, the content of total glucosinolates and the level of the reactive oxygen species in mature Arabidopsis thaliana plants after transferred into the stress-free environment.	oxygen species	214-228	cyclic nucleotide-gated cation channel 4	Arabidopsis thaliana	22-29
30129052-9	2018	Our results demonstrated that treatment of OSCC cells with LCC induced the death receptor (DR)4 and DR5 expression level with the generation of reactive oxygen species and the upregulation of CHOP protein expression.	oxygen species	153-167	major histocompatibility complex, class II, DR beta 4	Homo sapiens	59-95
30482886-0	2018	TGF-beta induces corneal endothelial senescence via increase of mitochondrial reactive oxygen species in chronic corneal allograft failure.	oxygen species	87-101	transforming growth factor alpha	Homo sapiens	0-8
30007118-0	2018	Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.	oxygen species	115-129	cytochrome b-245, beta polypeptide	Mus musculus	34-38
30007118-0	2018	Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.	oxygen species	115-129	coagulation factor II	Mus musculus	89-97
30125721-5	2018	More importantly, BODIPY3-PEG3 not only has better solubility and stability in aqueous media but can generate significant singlet oxygen (1O2, one of the reactive oxygen species, the real cytotoxic agent in photodynamic therapy) in living cells and exhibit high light cytotoxicity to three cancer cell lines.	oxygen species	163-177	paternally expressed 3	Homo sapiens	26-30
30061705-7	2018	Glomerular damage in adult shGRK2 mice was associated with increased renin- and AT1R-mediated production of reactive oxygen species.	oxygen species	117-131	angiotensin II, type I receptor-associated protein	Mus musculus	80-84
29878401-4	2018	Additionally, inhibition of BRD4 using small interfering RNA or JQ1 (a selective potent chemical inhibitor) led to repression of H2 O2 -induced oxidative stress, as revealed by a decrease in the reactive oxygen species production accompanied by a decreased malondialdehyde content, along with increased activities of antioxidant markers superoxide dismutase, catalase, and glutathione peroxidase on exposure of chondrocytes to H2 O2 .	oxygen species	204-218	bromodomain containing 4	Rattus norvegicus	28-32
29434932-6	2018	Notably, combination treatment of doxorubicin with quercetin significantly promoted the doxorubicin-induced apoptosis in PC3/R cells through the mitochondrial/reaction oxygen species pathway.	oxygen species	168-182	chromobox 8	Homo sapiens	121-124
27753160-0	2017	Pre-Transplantation Blockade of TNF-alpha-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.	oxygen species	51-65	tumor necrosis factor	Homo sapiens	32-41
28682389-2	2017	Of these, the high spin mono-histidine bound complexes produce significant amounts of partially reduced oxygen species (PROS), catalyze the degradation of neurotransmitters and oxidize cytochrome c, with potentially detrimental effects.	oxygen species	104-118	cytochrome c, somatic	Homo sapiens	185-197
27345267-3	2017	It has been further confirmed that irrespective of origin; brain insulin resistance triggers a cascade of the neurodegeneration phenomenon which can be aggravated by free reactive oxygen species burden, ER stress, metabolic dysfunction, neuorinflammation, reduced cell survival and altered lipid metabolism.	oxygen species	180-194	insulin	Homo sapiens	65-72
25808897-3	2015	In some recent investigations, peroxisome proliferator activated receptor gamma coactivator 1 alpha mediated mitochondrial biogenesis and its ability to restore reactive oxygen species-detoxifying enzymes have been observed in preclinical studies.	oxygen species	170-184	PPARG coactivator 1 alpha	Homo sapiens	31-99
27810365-9	2017	Furthermore, Nrf2 gene transfection reduced reactive oxygen species levels, thereby protecting neurons in the target region.	oxygen species	53-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
27466181-0	2016	Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.	oxygen species	36-50	huntingtin	Mus musculus	69-79
27394172-7	2016	Consequently, our data signifies that EC-SOD released from activated neutrophils affects the redox conditions of the extracellular space and may offer protection against highly reactive oxygen species such as hydroxyl radicals otherwise generated as a result of respiratory burst activity of activated neutrophils.	oxygen species	186-200	superoxide dismutase 3	Homo sapiens	38-44
25829510-6	2015	JNK activation and stabilization of p53, as a result of reactive oxygen species accumulation, are most likely the inducers of neuronal apoptosis in SOD2(nko) mice.	oxygen species	65-79	mitogen-activated protein kinase 8	Mus musculus	0-3
25829510-6	2015	JNK activation and stabilization of p53, as a result of reactive oxygen species accumulation, are most likely the inducers of neuronal apoptosis in SOD2(nko) mice.	oxygen species	65-79	transformation related protein 53, pseudogene	Mus musculus	36-39
25829510-6	2015	JNK activation and stabilization of p53, as a result of reactive oxygen species accumulation, are most likely the inducers of neuronal apoptosis in SOD2(nko) mice.	oxygen species	65-79	superoxide dismutase 2, mitochondrial	Mus musculus	148-152
25481834-7	2015	TNF-alpha alters mitochondrial complex-I activity, decreases adenosine triphosphate (ATP) levels, increases reactive oxygen species levels and mitochondrial turnover through autophagy.	oxygen species	117-131	tumor necrosis factor	Homo sapiens	0-9
27137951-5	2017	Pretreatment of insulin prevented the cell death and lowered the intracellular reactive oxygen species and calcium ion influx by MPP+.	oxygen species	88-102	insulin	Cricetulus griseus	16-23
27296112-4	2016	nNOS dimerization was disrupted in the 5 x FAD cortex, accompanied by an increase in reactive oxygen species (ROS) production.	oxygen species	94-108	nitric oxide synthase 1, neuronal	Mus musculus	0-4
27230708-4	2016	KEY FINDINGS: The inhibition of PI3K/Akt activation abolished the ability of NRG1 to prevent Abeta1-42 -induced LDH release and increased TUNEL-positive cell count and reactive oxygen species accumulation in primary cortical neurons.	oxygen species	177-191	neuregulin 1	Rattus norvegicus	77-81
25620490-6	2016	By revealing that levels of dihydrodiol dehydrogenase were promptly reduced following Cr(VI) challenge, our data suggested that DDH could be involved in a Cr(VI)-related oxidation to generate massive reactive oxygen species and H2 O2 , and to create intracellular hypoxia, which then increased levels of SUMO-1 activating enzyme subunit 2, and sumoylation of eukaryotic elongation factor-2, to mediate the subsequent molecular and cellular responses, e.g., expression of mesenchymal and stem cell markers.	oxygen species	209-223	aldo-keto reductase family 1 member C1	Homo sapiens	128-131
26813308-4	2016	In vitro study in colorectal cancer cells demonstrated inhibition of SCD1 activity promoted apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species (ROS), alteration of mitochondrial transmembrane potential and translocation of mitochondrial protein cytochrome C. While these effects were mediated by intracellular ceramide signals through induction of ceramide biosynthesis, rather than exclusive SFA accumulation.	oxygen species	168-182	stearoyl-Coenzyme A desaturase 1	Mus musculus	69-73
25410532-5	2015	beta-HB pretreatment also relieves the oxidative stress in Abeta-induced PC-12 cells, as shown by decreased intracellular reactive oxygen species and Ca(2+) levels, activated Nrf2 and recovered superoxide dismutase and catalase activities.	oxygen species	131-145	amyloid beta precursor protein	Rattus norvegicus	59-64
25145627-4	2014	Furthermore, UCP4A overexpression in pink1 mutants rescued mitochondria-specific phenotypes associated with mitochondrial membrane potential, production of reactive oxygen species, resistance to oxidative stress, efficiency of the electron transport chain, and mitochondrial morphology.	oxygen species	165-179	PTEN induced kinase 1	Homo sapiens	37-42
24763291-7	2014	Our study further indicated that the resultant haploinsufficiency of COQ6 might lead to CoQ10 deficiency and chronic overproduction of reactive oxygen species in Schwann cells.	oxygen species	144-158	putative N,N-dimethylaniline monooxygenase COQ6	Saccharomyces cerevisiae S288C	69-73
25369328-7	2014	Furthermore, sorted CD14(++)CD16(+) bone marrow cells show typical macrophage morphology, phagocytic activity, angiogenic features and generation of intracellular oxygen species.	oxygen species	163-177	CD14 molecule	Homo sapiens	20-24
25369328-7	2014	Furthermore, sorted CD14(++)CD16(+) bone marrow cells show typical macrophage morphology, phagocytic activity, angiogenic features and generation of intracellular oxygen species.	oxygen species	163-177	Fc gamma receptor IIIa	Homo sapiens	28-32
25214643-0	2014	Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1alpha activation through Nox2-dependent reactive oxygen species generation.	oxygen species	149-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-105
25214643-0	2014	Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1alpha activation through Nox2-dependent reactive oxygen species generation.	oxygen species	149-163	cytochrome b-245 beta chain	Homo sapiens	125-129
23855502-2	2014	Positive feedback mechanism of RAGE within blood-brain barrier (BBB) and/or cells inside the brain is proposed, including interaction with Abeta stimulating activation of proinflammatory cytokines, release of reactive oxygen species (ROS), which leads to neuron damage and BBB dysfunction.	oxygen species	218-232	advanced glycosylation end-product specific receptor	Homo sapiens	31-35
25076262-3	2014	The reduced metal bound Abeta active sites of both the oligomeric and fibrillar forms of Abeta produce detrimental partially reduced oxygen species (PROS).	oxygen species	133-147	amyloid beta precursor protein	Homo sapiens	24-29
25076262-3	2014	The reduced metal bound Abeta active sites of both the oligomeric and fibrillar forms of Abeta produce detrimental partially reduced oxygen species (PROS).	oxygen species	133-147	amyloid beta precursor protein	Homo sapiens	89-94
23963778-0	2014	Electrophilic and reactive oxygen species detoxification potentials of chalcone dimers is mediated by redox transcription factor Nrf-2.	oxygen species	27-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-134
24021285-4	2013	The results show that ASK1 acts as a primary mediator of there active oxygen species (ROS) cell death signal cascade in the 3-NP-damaged striatal region by disrupting the positive feedback cycle.	oxygen species	70-84	mitogen-activated protein kinase kinase kinase 5	Mus musculus	22-26
24005821-5	2014	Recent work has implicated the FAD-oxidase protein Erv1 (ad its human homolog Augmenter of Liver Regeneration) as an anti-apoptotic factor in mammalian cells (including neuronal cells) that undergo Reactive Oxygen Species-triggered apoptosis.	oxygen species	207-221	growth factor, augmenter of liver regeneration	Homo sapiens	51-55
24139263-9	2013	TEGDMA-induced COX-2 expression was associated with reaction oxygen species, the extracellular signal-regulated kinase 1/2, and the p38 mitogen-activated protein kinase signaling pathways in HDP and HEPM cells.	oxygen species	61-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	15-20
21536589-6	2011	In response to oxidative stress, LCs from SCA3 patients show a specific impairment to upregulate SOD2 expression in correlation with a significantly increased formation of reactive oxygen species and cytotoxicity.	oxygen species	181-195	ataxin 3	Homo sapiens	42-46
24205282-10	2013	These data reveal that the circadian clock plays an important role in the control of Nox4 and disruption of the clock leads to subsequent production of reaction oxygen species.	oxygen species	161-175	NADPH oxidase 4	Mus musculus	85-89
23811400-11	2013	Finally, we prove the advantages of the PPAR triad concept by describing hypotheses of PPARbeta/delta involvement in the regulation of myelination, glutamate-induced neurotoxicity, and signaling pathways of reactive oxygen species/NO/Ca(2+).	oxygen species	216-230	peroxisome proliferator activated receptor alpha	Homo sapiens	40-44
23689269-1	2013	Partially reduced oxygen species (PROS), produced by reduced heme bound Abeta peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer"s disease.	oxygen species	18-32	amyloid beta precursor protein	Homo sapiens	72-77
23246553-1	2013	Apoptosis-inducing factor (AIF) is a flavin-binding mitochondrial intermembrane space protein that is implicated in diverse but intertwined processes that include maintenance of electron transport chain function, reactive oxygen species regulation, cell death, and neurodegeneration.	oxygen species	222-236	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	0-25
23246553-1	2013	Apoptosis-inducing factor (AIF) is a flavin-binding mitochondrial intermembrane space protein that is implicated in diverse but intertwined processes that include maintenance of electron transport chain function, reactive oxygen species regulation, cell death, and neurodegeneration.	oxygen species	222-236	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	27-30
23282799-2	2013	In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Abeta peptides.	oxygen species	134-148	amyloid beta precursor protein	Homo sapiens	162-167
23382999-7	2013	The potential mechanisms of the protective effects of lacking CypD on Abeta-induced abnormal mitochondrial transport in axon are increased axonal calcium buffer capability, diminished reactive oxygen species (ROS), and suppressing downstream signal transduction P38 activation.	oxygen species	193-207	peptidylprolyl isomerase D	Homo sapiens	62-66
23382999-7	2013	The potential mechanisms of the protective effects of lacking CypD on Abeta-induced abnormal mitochondrial transport in axon are increased axonal calcium buffer capability, diminished reactive oxygen species (ROS), and suppressing downstream signal transduction P38 activation.	oxygen species	193-207	amyloid beta precursor protein	Homo sapiens	70-75
22581365-3	2012	Accumulating evidence indicates that activation of the NOX2 enzyme complex in microglia is neurotoxic, both through the production of extracellular reactive oxygen species that damage neighboring neurons as well as the initiation of redox signaling in microglia that amplifies the pro-inflammatory response.	oxygen species	157-171	cytochrome b-245 beta chain	Homo sapiens	55-59
22549002-3	2012	The induction of the heme oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system in the brain represents one of the earliest mechanisms activated by cells to counteract the noxious effects of increased reactive oxygen species and reactive nitrogen species.	oxygen species	211-225	heme oxygenase 1	Homo sapiens	21-60
22549002-3	2012	The induction of the heme oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system in the brain represents one of the earliest mechanisms activated by cells to counteract the noxious effects of increased reactive oxygen species and reactive nitrogen species.	oxygen species	211-225	heme oxygenase 1	Homo sapiens	62-66
22549002-3	2012	The induction of the heme oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system in the brain represents one of the earliest mechanisms activated by cells to counteract the noxious effects of increased reactive oxygen species and reactive nitrogen species.	oxygen species	211-225	biliverdin reductase A	Homo sapiens	67-72
22010830-9	2012	Feeding of anti-reactive oxygen species agents partially rescue the drd from sudden death.	oxygen species	25-39	drop dead	Drosophila melanogaster	68-71
23214455-2	2013	Recently the Abeta peptides have been demonstrated to bind heme and Cu simultaneously, and this complex produces significantly more toxic partially reduced oxygen species (PROS) than the Cu or heme-bound Abeta peptides.	oxygen species	156-170	amyloid beta precursor protein	Homo sapiens	13-18
23000247-8	2012	These results indicate that CPN-9 exerts its activity via the reactive oxygen species-dependent activation of the Nrf2 signaling pathway in cultured cells.	oxygen species	71-85	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
21796667-1	2011	OBJECTIVE: Loss of function mutations of Park7/DJ-1 gene increase the susceptibility of dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD).	oxygen species	119-133	Parkinsonism associated deglycase	Homo sapiens	41-46
21796667-1	2011	OBJECTIVE: Loss of function mutations of Park7/DJ-1 gene increase the susceptibility of dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD).	oxygen species	119-133	Parkinsonism associated deglycase	Homo sapiens	47-51
21536589-6	2011	In response to oxidative stress, LCs from SCA3 patients show a specific impairment to upregulate SOD2 expression in correlation with a significantly increased formation of reactive oxygen species and cytotoxicity.	oxygen species	181-195	superoxide dismutase 2	Homo sapiens	97-101
20150559-7	2010	Pharmacological reactive oxygen species scavengers and inhibition of ERK activation blocked oxidized LDL-mediated CREB downregulation.	oxygen species	25-39	cAMP responsive element binding protein 1	Rattus norvegicus	114-118
20952677-7	2010	Taken together, our results suggest that the BLT2-Nox1-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs, thus contributing to allergic response.	oxygen species	64-78	NADPH oxidase 1	Homo sapiens	50-54
19582548-4	2010	We showed that the mechanisms by which Abeta oligomers and fibrils generated reactive oxygen species differ in terms of site of production and kinetics, suggesting the involvement of different intra/extracellular pathways.	oxygen species	86-100	amyloid beta precursor protein	Homo sapiens	39-44
20952677-7	2010	Taken together, our results suggest that the BLT2-Nox1-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs, thus contributing to allergic response.	oxygen species	64-78	leukotriene B4 receptor 2	Homo sapiens	45-49
20186922-7	2010	Moreover, glycation may be responsible, via the receptor for AGE (RAGE), for an increase in oxidative stress and inflammation through the formation of reactive oxygen species and the induction of NF-kappaB.	oxygen species	160-174	renin binding protein	Homo sapiens	61-64
20186922-7	2010	Moreover, glycation may be responsible, via the receptor for AGE (RAGE), for an increase in oxidative stress and inflammation through the formation of reactive oxygen species and the induction of NF-kappaB.	oxygen species	160-174	advanced glycosylation end-product specific receptor	Homo sapiens	66-70
17018883-2	2006	SIN-1-induced lipid peroxidation, reactive oxygen species synthesis, caspase-3 activation, and apoptosis were attenuated by metallothionein gene overexpression and augmented by metallothionein gene down-regulation.	oxygen species	43-57	MAPK associated protein 1	Homo sapiens	0-5
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	leukotriene B4 receptor 2	Homo sapiens	41-45
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	NADPH oxidase 1	Homo sapiens	46-50
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	interleukin 1 beta	Homo sapiens	207-215
18717629-5	2009	Because common mechanisms of neurodegeneration, such as mitochondrial dysfunction and build-up of reactive oxygen species, are currently being uncovered, targeting Nrf2 may be valuable in combating conditions with variable causes and etiologies.	oxygen species	107-121	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
18201545-1	2008	Reactive nitrogen species (RNS) and oxygen species (ROS) have been reported to modulate the function of nitric oxide synthase (NOS); however, the precise dose-dependent effects of specific RNS and ROS on NOS function are unknown.	oxygen species	36-50	nitric oxide synthase 1	Homo sapiens	104-125
17055439-0	2006	Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.	oxygen species	24-38	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	68-73
19748928-0	2010	Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.	oxygen species	95-109	estrogen receptor 1	Homo sapiens	16-33
19748928-0	2010	Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.	oxygen species	95-109	leukotriene B4 receptor 2	Homo sapiens	81-85
18422522-5	2008	eNOS activation by TNF-alpha conferred cytoprotection from excitotoxicity and neurotoxic cues such as reactive oxygen species, endoplasmic reticulum stress, DNA damage, and mutated alsin itself.	oxygen species	111-125	nitric oxide synthase 3	Homo sapiens	0-4
18422522-5	2008	eNOS activation by TNF-alpha conferred cytoprotection from excitotoxicity and neurotoxic cues such as reactive oxygen species, endoplasmic reticulum stress, DNA damage, and mutated alsin itself.	oxygen species	111-125	tumor necrosis factor	Homo sapiens	19-28
17822363-3	2007	Mitochondria, in the presence of Alzheimer"s amyloid-beta peptide, increase the formation of reactive oxygen species which act both as damaging agents and also as signaling molecules.	oxygen species	102-116	amyloid beta precursor protein	Homo sapiens	45-57
17183144-1	2006	Gain-of-function mutations in the presenilin-1 (PS-1) promote Alzheimer"s disease (AD) by increasing reactive oxygen species, at least part of which is derived by an accompanying increase in generation of amyloid-beta (Abeta).	oxygen species	110-124	presenilin 1	Mus musculus	48-52
15784009-0	2005	Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.	oxygen species	146-160	interleukin 1 beta	Mus musculus	0-17
16462764-1	2006	Overexpression of the c-Met/hepatocyte growth factor receptor(HGF-R) proto-oncogene and abnormal generation of intracellular oxygen species (reactive oxygen species (ROS)) have been linked, by independent lines of evidence, to cell transformation and to malignant growth.	oxygen species	125-139	met proto-oncogene	Mus musculus	22-27
15081107-5	2004	Moreover, the LEW/Mol strain had higher production of radical oxygen species in peripheral blood leukocytes, a phenomenon most likely regulated by the polymorphisms in the Ncf1 gene.	oxygen species	62-76	neutrophil cytosolic factor 1	Rattus norvegicus	172-176
15155565-6	2004	The ABCA2 transfected cell line expressed resistance to a free radical initiator, confirming involvement in protection against reactive oxygen species and suggesting a further possible link to AD.	oxygen species	136-150	ATP binding cassette subfamily A member 2	Homo sapiens	4-9
12393560-8	2002	In addition, z-VAD-fmk amplifies the differentiation-associated production of radical oxygen species in both phorbol ester-differentiated U937 cells and M-CSF-treated monocytes, shifting the differentiation process to nonapoptotic cell death.	oxygen species	86-100	colony stimulating factor 1	Homo sapiens	153-158
15082344-6	2004	The study indicated that ascorbic acid-2-o-phosphate-6-o-palmitate could not only significantly reduce the intracellular reactive oxygen species level in 3 h culture, but also increase the cell viability in 15 h culture.	oxygen species	130-144	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	34-40
12678687-4	2003	Among recent advances are the discoveries that reactive nitrogen species (RNS), oxygen species (ROS), cytokines, and growth factors participate in stability regulation of HIF-1alpha and HIF-1 transactivation during normoxia.	oxygen species	80-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
12678687-4	2003	Among recent advances are the discoveries that reactive nitrogen species (RNS), oxygen species (ROS), cytokines, and growth factors participate in stability regulation of HIF-1alpha and HIF-1 transactivation during normoxia.	oxygen species	80-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-176
15086456-0	2004	Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells.	oxygen species	9-23	proline rich transmembrane protein 2	Homo sapiens	32-48
15086456-0	2004	Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells.	oxygen species	9-23	fibronectin 1	Homo sapiens	83-94
12527286-6	2003	An electron spin resonance study clearly demonstrated the ability of metal ions to generate activated oxygen species (AOS), especially hydroxyl radicals (*OH), which accounts for PDTC-blockade of metal ion-induced NF-kappaB activation and subsequent cytokine production.	oxygen species	102-116	nuclear factor kappa B subunit 1	Homo sapiens	214-223
12594242-6	2003	These adverse effects of NOS3 were associated with increased cellular levels of reactive oxygen species and impaired membrane integrity and were not produced in cells that were transfected with a cDNA encoding catalytically inactive NOS3.	oxygen species	89-103	nitric oxide synthase 3	Homo sapiens	25-29
12040026-5	2002	Of the other two sequenced amplicons, one encoded a partial sequence for mitochondrial manganese-dependent superoxide dismutase (SOD2), an enzyme that is likely to protect adrenocortical cells from the cytotoxic effects of radical oxygen species generated during steroid biosynthesis.	oxygen species	231-245	superoxide dismutase 2, mitochondrial	Bos taurus	129-133
1567225-1	1992	The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the reaction of XO-derived partially reduced oxygen species (PROS) have been suggested to be important in diverse mechanisms of tissue pathophysiology, including oxygen toxicity.	oxygen species	121-135	xanthine dehydrogenase	Bos taurus	18-40
11709424-6	2001	Treatment of VSM cells with NAC selectively inhibited the sustained phase of ERK activation without influencing the transient phase, suggesting a role for reactive oxygen species in sustained ERK activation.	oxygen species	164-178	mitogen-activated protein kinase 1	Homo sapiens	192-195
11775062-8	2001	Most importantly, they embrace pathological mechanisms known to develop in aging (which is the most important risk factor for AD), such as increased production of reactive oxygen species by mitochondria, that can be positioned upstream relative to the generation of A beta.	oxygen species	172-186	amyloid beta precursor protein	Homo sapiens	266-272
11083573-18	2000	The toxic effects of highly reactive oxygen species on fat cells might explain the failure of an excessively high dose of hyperbaric oxygen to provide any beneficial outcome.	oxygen species	37-51	CD36 molecule	Mus musculus	55-58
7648404-11	1995	However, DHOdehase should be considered as a source of radical oxygen species under pathophysiological conditions.	oxygen species	63-77	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	9-18
11698338-3	2001	Using 2",7"-dichlorofluorescin diacetate, a dye that fluoresces in the presence of hydrogen peroxide or hydroxyl radicals, we found that prostate specific antigen markedly stimulated reactive oxygen species generation in LNCaP cells.	oxygen species	192-206	kallikrein related peptidase 3	Homo sapiens	137-162
9430557-10	1998	The possible role of ceruloplasmin in inhibiting reaction oxygen species in the retina after injury is discussed.	oxygen species	58-72	ceruloplasmin	Rattus norvegicus	21-34
1567225-1	1992	The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the reaction of XO-derived partially reduced oxygen species (PROS) have been suggested to be important in diverse mechanisms of tissue pathophysiology, including oxygen toxicity.	oxygen species	121-135	xanthine dehydrogenase	Bos taurus	42-45