PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30798053-2	2019	Two scaffolds, targeting AChE (tacrine) and GSK-3alpha/beta (valmerin) simultaneously, were assembled, using copper(I)-catalysed azide alkyne cycloaddition (CuAAC), to generate a new series of multifunctional ligands.	valmerin	61-69	glycogen synthase kinase 3 alpha	Homo sapiens	44-54
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	77-85	glycogen synthase kinase 3 beta	Homo sapiens	92-100
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	77-85	cyclin dependent kinase 5	Homo sapiens	101-105
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	77-85	glycogen synthase kinase 3 beta	Homo sapiens	279-287
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	77-85	cyclin dependent kinase 5	Homo sapiens	288-292
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	219-227	glycogen synthase kinase 3 beta	Homo sapiens	92-100
25142337-3	2014	Detailed MM-PBSA calculations revealed that the binding free energies of the valmerin-19 to GSK3beta/CDK5 were calculated to be -12.60 +- 2.28 kcal mol(-1) and -11.85 +- 2.54 kcal mol(-1), respectively, indicating that valmerin-19 has the potential to act as a dual inhibitor of GSK3beta/CDK5.	valmerin	219-227	cyclin dependent kinase 5	Homo sapiens	101-105