PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34979196-14	2022	Glycogen synthase kinase-3beta and caspase-3 play role in Pb acetate-induced hepatic damage.	pb acetate	58-68	glycogen synthase kinase 3 beta	Rattus norvegicus	0-30
10702365-6	2000	Exposure of cultured C6 rat glioma cells, an astroglia-like cell line, to 1 microM Pb acetate for 1 week raised the intracellular levels of two proteins, one of which was identified by sequence analysis as GRP78.	pb acetate	83-93	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	206-211
7617547-2	1995	of Pb acetate after chronic treatment through oral gavage on: (a) the distribution of trace elements such as Fe, Cu, Zn, and Mn, (b) enzyme activity of delta-amino levulinic acid dehydratase (delta-ALAD) and alkaline phosphatase, and (c) glutathione (GSH) in kidney and (d) delta-ALAD in blood of pregnant and non-pregnant mice.	pb acetate	3-13	aminolevulinate, delta-, dehydratase	Mus musculus	152-190
7617547-2	1995	of Pb acetate after chronic treatment through oral gavage on: (a) the distribution of trace elements such as Fe, Cu, Zn, and Mn, (b) enzyme activity of delta-amino levulinic acid dehydratase (delta-ALAD) and alkaline phosphatase, and (c) glutathione (GSH) in kidney and (d) delta-ALAD in blood of pregnant and non-pregnant mice.	pb acetate	3-13	aminolevulinate, delta-, dehydratase	Mus musculus	192-202
7617547-2	1995	of Pb acetate after chronic treatment through oral gavage on: (a) the distribution of trace elements such as Fe, Cu, Zn, and Mn, (b) enzyme activity of delta-amino levulinic acid dehydratase (delta-ALAD) and alkaline phosphatase, and (c) glutathione (GSH) in kidney and (d) delta-ALAD in blood of pregnant and non-pregnant mice.	pb acetate	3-13	aminolevulinate, delta-, dehydratase	Mus musculus	274-284
7715861-5	1994	Basal cerebellar ODC activity in homogenates was increased with addition of low concentrations of Pb acetate (0.01 microM and 0.1 microM), while concentrations of 1 microM or greater were inhibitory.	pb acetate	98-108	ornithine decarboxylase 1	Rattus norvegicus	17-20
7715861-6	1994	The effects of Pb acetate on tissue ODC activity in vitro were not mimicked by the addition of calcium chloride.	pb acetate	15-25	ornithine decarboxylase 1	Rattus norvegicus	36-39
15111246-3	2001	In this study, we examined the effects of Pb acetate and HgCl(2) on the expression of GRP78, a molecular chaperone in the endoplasmic reticulum (ER) that may provide cytoprotection in response to cellular stresses in the C6 rat glioma cell line.	pb acetate	42-52	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	86-91
34979196-14	2022	Glycogen synthase kinase-3beta and caspase-3 play role in Pb acetate-induced hepatic damage.	pb acetate	58-68	caspase 3	Rattus norvegicus	35-44
29665650-6	2018	Surprisingly, miR-224, a direct complementary target of ID1 mRNA, expression in the thyroid tissues was significantly down-regulated in Nano-Se-pre- and co-treated Pb acetate intoxicated animals.	pb acetate	164-174	microRNA 224	Rattus norvegicus	14-21
30703413-5	2019	Exposure to Pb acetate adversely affected the measured acetyl cholinesterase enzyme activity, oxidative stress and lipid peroxidation parameters as well as caspase-3 gene expression in brain tissue (cerebrum and cerebellum).	pb acetate	12-22	butyrylcholinesterase	Rattus norvegicus	62-76
30703413-5	2019	Exposure to Pb acetate adversely affected the measured acetyl cholinesterase enzyme activity, oxidative stress and lipid peroxidation parameters as well as caspase-3 gene expression in brain tissue (cerebrum and cerebellum).	pb acetate	12-22	caspase 3	Rattus norvegicus	156-165
15713347-5	2005	A rat GRP78-EGFP fusion protein and EGFP were transiently expressed in astrocytoma cells exposed to 5 microM Pb acetate or 50 microM CuSO4 and fluorescence signals were captured.	pb acetate	109-119	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	6-11
28817314-5	2018	Serum aspartate aminotransferase and alanine aminotransferase activities increased in the Pb acetate group.	pb acetate	90-100	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	6-32
28071527-3	2017	Pb acetate exposure induced significant elevation in serum alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme activities in group 2 compared to control group.	pb acetate	0-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	87-113
28071527-3	2017	Pb acetate exposure induced significant elevation in serum alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme activities in group 2 compared to control group.	pb acetate	0-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	115-118
24311739-5	2014	Exposure of rats to Pb (single ip injection of 50 mg Pb acetate/kg) for 24 h increased ZnT2 fluorescent signals in plexus tissues by confocal imaging and protein expression by western blot.	pb acetate	53-63	solute carrier family 30 member 2	Rattus norvegicus	87-91
19747378-4	2009	METHODS: Rats were injected with a single dose of Pb acetate or an equivalent concentration of Na-acetate; CP tissues were processed to detect the location of IDE by immunohistochemistry.	pb acetate	50-60	insulin degrading enzyme	Rattus norvegicus	159-162
27476969-5	2016	RESULTS: Pb acetate exposed rats showed a significant decrease in the epididymal sperm count, motility, viability, serum testosterone level and testicular expression of 3beta-HSD, 17beta-HSD and PCNA compared to the control group, while treatment with SSCs attenuated Pb acetate induced decrease for these variables.	pb acetate	9-19	proliferating cell nuclear antigen	Rattus norvegicus	195-199
27476969-6	2016	Moreover, the increasing apoptosis of germinal cells as well as the high expression of caspase-3 induced by Pb acetate was reduced by SSCs treatment.	pb acetate	108-118	caspase 3	Rattus norvegicus	87-96
17565513-3	2007	The cells pretreated with the MEK1 (mitogen-activated protein kinase kinase 1) inhibitor PD98059 and bFGF, respectively, were exposed to Pb acetate of different concentrations for different times.	pb acetate	137-147	fibroblast growth factor 2	Rattus norvegicus	101-105
12206816-5	2002	Pretreatment with Pb acetate (500 nM-10 microM) attenuated the generation of NO in a concentration-dependent manner up to 90%, and suppressed iNOS protein expression, as well as interfered with the homeostatic functions of calcium in the cytokine-induced NO signal transduction pathway.	pb acetate	18-28	nitric oxide synthase 2	Homo sapiens	142-146