PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22863933-0 2012 Targeting of the Sonic Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells. atractylenolides 43-59 sonic hedgehog signaling molecule Homo sapiens 17-31 22863933-7 2012 Phenotypic cellular analysis indicated that atractylenolides induced MSCs to differentiate into chondrocytes, as shown by increased expression of specific chondrogenic markers including collagen II, aggrecan and the cartilage related transcription factor, Sox9. atractylenolides 44-60 SRY-box transcription factor 9 Homo sapiens 256-260 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 0-16 sonic hedgehog signaling molecule Homo sapiens 59-62 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 0-16 GLI family zinc finger 1 Homo sapiens 83-88 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 0-16 sonic hedgehog signaling molecule Homo sapiens 106-109 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 137-153 sonic hedgehog signaling molecule Homo sapiens 59-62 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 137-153 GLI family zinc finger 1 Homo sapiens 83-88 22863933-8 2012 Atractylenolides significantly increased the expression of Shh and its target gene Gli-1, indicating that Shh signaling was activated by atractylenolides. atractylenolides 137-153 sonic hedgehog signaling molecule Homo sapiens 106-109 22863933-9 2012 Moreover, inhibition of Shh signaling reduced the effect of atractylenolides on the chondrogenic phenotype. atractylenolides 60-76 sonic hedgehog signaling molecule Homo sapiens 24-27 30907503-8 2019 Interestingly, atractylenolides not only switched the expressions of XIST, miR-30a-5p and ROR1 within colorectal cancer cells but also significantly intensified the chemosensitivity of colorectal cancer cells (P < 0.05). atractylenolides 15-31 X inactive specific transcript Homo sapiens 69-73 30907503-8 2019 Interestingly, atractylenolides not only switched the expressions of XIST, miR-30a-5p and ROR1 within colorectal cancer cells but also significantly intensified the chemosensitivity of colorectal cancer cells (P < 0.05). atractylenolides 15-31 microRNA 30a Homo sapiens 75-82 30907503-8 2019 Interestingly, atractylenolides not only switched the expressions of XIST, miR-30a-5p and ROR1 within colorectal cancer cells but also significantly intensified the chemosensitivity of colorectal cancer cells (P < 0.05). atractylenolides 15-31 receptor tyrosine kinase like orphan receptor 1 Homo sapiens 90-94