PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16092936-7	2005	The effects of both antagonists were no longer apparent in rats with a previous 5-HT depletion induced by the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA), suggesting that 5-HT(1A) receptor blockade removes the tonic inhibition of 5-HT through 5-HT(1A) receptor stimulation on excitatory hippocampal neurons, with the consequent increase in PKA activity.	Fenclonine	143-164	5-hydroxytryptamine receptor 1A	Rattus norvegicus	189-196
16102522-7	2005	Myeloperoxidase activity in inflamed paws was reduced significantly in groups received PCPA (either i.c.v.	Fenclonine	87-91	myeloperoxidase	Rattus norvegicus	0-15
16042979-11	2005	Similarly, pre-treatment with PCPA also significantly attenuated the anti-immobility effects of NPY, thus suggesting a role for 5-HT in the effects of NPY in the FST.	Fenclonine	30-34	neuropeptide Y	Mus musculus	96-99
16042979-11	2005	Similarly, pre-treatment with PCPA also significantly attenuated the anti-immobility effects of NPY, thus suggesting a role for 5-HT in the effects of NPY in the FST.	Fenclonine	30-34	neuropeptide Y	Mus musculus	151-154
15688089-3	2005	The behavioral phenotype was identified as likely due to a disinhibition of 5-HT release, because depletion of 5-HT with parachlorophenylalanine selectively reduced immobility of female 5-HT1B receptor knockout mice in the TST.	Fenclonine	121-144	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	186-201
15892984-5	2005	We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha.	Fenclonine	97-101	tumor necrosis factor	Homo sapiens	72-80
15892984-5	2005	We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha.	Fenclonine	97-101	interleukin 6	Homo sapiens	156-160
15892984-5	2005	We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha.	Fenclonine	97-101	tumor necrosis factor	Homo sapiens	165-173
15892984-5	2005	We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha.	Fenclonine	97-101	interleukin 6	Homo sapiens	156-160
15892984-5	2005	We found that: (1) 5-HT, 15 microg/ml, significantly decreased IL-6 and TNFalpha production; (2) pCPA, 5 microM, significantly suppressed the production of IL-6 and TNFalpha; and (3) mCPP, 2.7 microg/ml, significantly increased the production of IL-6 and TNFalpha.	Fenclonine	97-101	tumor necrosis factor	Homo sapiens	165-173
15809439-7	2005	Lowering brain 5-HT levels by administration of the selective tryptophan hydroxylase inhibitor p-chlorophenylalanine on postnatal days 0 and 1 restored the metabolic responses to functional activation in the whisker-to-barrel cortex pathway in adult 5-HTT(-/-) mice.	Fenclonine	95-116	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	250-255
15809439-9	2005	With or without postnatal p-chlorophenylalanine treatment, 5-HTT(-/-) mice exhibited lower resting (unstimulated) lCMR(glc) than did 5-HTT(+/+) controls in the whisker-to-barrel cortex pathway and throughout the brain.	Fenclonine	26-47	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	59-64
15562014-3	2005	This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine, both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatonin.	Fenclonine	205-228	interleukin 2	Homo sapiens	93-97
15562014-3	2005	This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine, both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatonin.	Fenclonine	205-228	interleukin 2	Homo sapiens	98-102
15562014-3	2005	This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine, both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatonin.	Fenclonine	205-228	interleukin 2	Homo sapiens	98-102
15562014-3	2005	This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine, both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatonin.	Fenclonine	205-228	interleukin 2 receptor subunit beta	Homo sapiens	98-111
15466248-1	2005	To investigate the role of serotonin (5-HT), an important neurotransmitter and hormone/paracrine agent in the small intestine, in the transport activity of P-glycoprotein (P-gp), the intestinal transport of quinidine, a P-gp substrate, was examined in 5-HT-depleted rats prepared by intraperitoneal administration of p-chlorophenylalanine, a specific inhibitor of tryptophan hydroxylase in 5-HT biosynthesis.	Fenclonine	317-338	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	156-170
15677425-6	2004	PCPA, however, reversed stress-induced hippocampal 5HT(1A) receptor affinity changes, with FLX narrowly missing significance.	Fenclonine	0-4	5-hydroxytryptamine receptor 1A	Homo sapiens	51-67
15034919-6	2004	After inducing acute 5-HT depletion with pCPA, we observed an increase in in vivo [125I]ADAM binding in all brain areas studied.	Fenclonine	41-45	ADAM metallopeptidase domain 7	Rattus norvegicus	88-92
15034919-7	2004	The higher in vivo binding of [125I]ADAM in pCPA-treated rats than in controls was mainly due to an increase in specific binding to the SERT, as demonstrated by greatly reduced binding in the presence of a saturating dose of paroxetine.	Fenclonine	44-48	ADAM metallopeptidase domain 7	Rattus norvegicus	36-40
15034919-7	2004	The higher in vivo binding of [125I]ADAM in pCPA-treated rats than in controls was mainly due to an increase in specific binding to the SERT, as demonstrated by greatly reduced binding in the presence of a saturating dose of paroxetine.	Fenclonine	44-48	solute carrier family 6 member 4	Rattus norvegicus	136-140
15063148-0	2004	MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities.	Fenclonine	10-31	solute carrier family 6 member 4	Homo sapiens	85-106
14622177-7	2003	Cell aggregates treated with an antibody against FGF-4 or with the serotonergic toxin 5,7-dyhydroxytryptamine or the serotonin synthesis inhibitor dl-p-chlorophenylalanine showed a marked decrease in the number of 5-HT-ir cells (10-20% of controls) and a marked increase in that of TH-ir neurons (700-900% of controls).	Fenclonine	147-171	fibroblast growth factor 4	Rattus norvegicus	49-54
12716405-7	2003	At E18 and E21, the fractions of GnRH neurones in the rostral part of the trajectory in pCPA-treated foetuses were greater than those in control foetuses but the opposite was true for the caudal part of the trajectory.	Fenclonine	88-92	gonadotropin releasing hormone 1	Rattus norvegicus	33-37
12673041-6	2003	MK-801-induced rise of plasma IL-6 level was markedly enhanced in the PCPA-pretreated mice.	Fenclonine	70-74	interleukin 6	Mus musculus	30-34
12605405-5	2003	Inhibiting serotonin or noradrenaline synthesis in Tg8 mice by the administration of parachlorophenylalanine or alpha-methylparatyrosine, respectively, the amounts of AVP, VIP and their mRNAs were decreased, but not the number of peptidergic neurons.	Fenclonine	85-108	arginine vasopressin	Mus musculus	167-170
12605405-5	2003	Inhibiting serotonin or noradrenaline synthesis in Tg8 mice by the administration of parachlorophenylalanine or alpha-methylparatyrosine, respectively, the amounts of AVP, VIP and their mRNAs were decreased, but not the number of peptidergic neurons.	Fenclonine	85-108	vasoactive intestinal polypeptide	Mus musculus	172-175
14753474-0	2003	Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord.	Fenclonine	49-54	heme oxygenase 2	Rattus norvegicus	106-122
14753474-5	2003	Upregulation of HO-2 in p-CPA treated traumatised rats was considerably reduced.	Fenclonine	24-29	heme oxygenase 2	Rattus norvegicus	16-20
12031854-6	2002	However, depletion of 5-HT by treatment with p-chlorophenylalanine (p-CPA) increased burying behavior in NMB-R-deficient mice suggesting that increased levels of 5-HT in the brain cause a decrease in burying behavior in NMB-R-deficient mice.	Fenclonine	45-66	neuromedin B receptor	Mus musculus	105-110
12614685-9	2003	administration of endothelin-1 (1 pmol) significantly increased the serotonin (5-hydroxytryptamine) turnover in some brain regions, i.e., the cerebral cortex, hippocampus and midbrain, and the inhibition of brain 5-hydroxytryptamine synthesis by treatment with p-chlorophenylalanine (200 mg/kg/day, s.c.) for 2 days suppressed the behavioral effects of endothelin-1 (1 pmol, i.c.v.).	Fenclonine	261-282	endothelin 1	Rattus norvegicus	18-30
12468035-10	2002	Increased nNOS immunoreactivity in striatum and hippocampus as well as increased NADPHd reactivity in the striatum, hippocampus and parietal cortex were found after PCPA treatment.	Fenclonine	165-169	nitric oxide synthase 1	Homo sapiens	10-14
12468035-11	2002	The iNOS immunoreactivity in the corpus callosum increased 14 and 35 days after the end of PCPA treatment.	Fenclonine	91-95	nitric oxide synthase 2	Homo sapiens	4-8
12398910-0	2002	MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities.	Fenclonine	10-31	solute carrier family 6 member 4	Rattus norvegicus	85-106
12422375-4	2003	Acute serotonergic lesions with p-chlorophenylalanine suppressed the expression of Fos induced by 1 mg/kg of amphetamine in both the grafted and the contralateral striatum.	Fenclonine	32-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-86
12031854-6	2002	However, depletion of 5-HT by treatment with p-chlorophenylalanine (p-CPA) increased burying behavior in NMB-R-deficient mice suggesting that increased levels of 5-HT in the brain cause a decrease in burying behavior in NMB-R-deficient mice.	Fenclonine	45-66	neuromedin B receptor	Mus musculus	220-225
12031854-6	2002	However, depletion of 5-HT by treatment with p-chlorophenylalanine (p-CPA) increased burying behavior in NMB-R-deficient mice suggesting that increased levels of 5-HT in the brain cause a decrease in burying behavior in NMB-R-deficient mice.	Fenclonine	68-73	neuromedin B receptor	Mus musculus	105-110
12031854-6	2002	However, depletion of 5-HT by treatment with p-chlorophenylalanine (p-CPA) increased burying behavior in NMB-R-deficient mice suggesting that increased levels of 5-HT in the brain cause a decrease in burying behavior in NMB-R-deficient mice.	Fenclonine	68-73	neuromedin B receptor	Mus musculus	220-225
12031347-9	2002	In the serotonin transporter knockout mice however, the contralateral retinal fibres failed to retract from the mediodorsal dorsal lateral geniculate nucleus, an abnormality that was reversed by early treatment with parachlorophenylalanine and in the serotonin transporter/5-HT(1B) double knockout.	Fenclonine	216-239	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	273-280
12112407-8	2002	Golgi and RICC data indicate that CA1 apical spine density was significantly decreased by pCPA (17-20%).	Fenclonine	90-94	carbonic anhydrase 1	Rattus norvegicus	34-37
12112407-11	2002	Depletion of 5-HT by pCPA was confirmed in the CA1 (-90%) and dorsal raphe (-80%) by HPLC analysis.	Fenclonine	21-25	carbonic anhydrase 1	Rattus norvegicus	47-50
11880481-8	2002	The pCPA treatment in Tg8 mice was also associated with a decrease in OT expression in the PVN and SON and in AVP expression in the PVN, but not in the SON.	Fenclonine	4-8	arginine vasopressin	Mus musculus	110-113
11595215-3	2001	Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.	Fenclonine	19-39	interleukin 1 beta	Rattus norvegicus	90-98
11722603-4	2001	Combining ovariectomy with inhibition of 5-HT synthesis using p-chlorophenylalanine (PCPA) treatment produced approximately the same decreases in the number of bromodeoxyuridine (BrdU) and PSA-NCAM immunolabelled cells in the subgranular layer as ovariectomy alone.	Fenclonine	62-83	neural cell adhesion molecule 1	Homo sapiens	193-197
11722603-4	2001	Combining ovariectomy with inhibition of 5-HT synthesis using p-chlorophenylalanine (PCPA) treatment produced approximately the same decreases in the number of bromodeoxyuridine (BrdU) and PSA-NCAM immunolabelled cells in the subgranular layer as ovariectomy alone.	Fenclonine	85-89	neural cell adhesion molecule 1	Homo sapiens	193-197
11456281-3	2001	The aim of the present study was to investigate the ability of estrogen to modify the effect of pCPA on prolactin secretion and to evaluate the participation of opioid and/or dopaminergic systems in regulating pCPA-induced prolactin secretion in estradiol-treated rats.	Fenclonine	96-100	prolactin	Rattus norvegicus	104-113
11456281-3	2001	The aim of the present study was to investigate the ability of estrogen to modify the effect of pCPA on prolactin secretion and to evaluate the participation of opioid and/or dopaminergic systems in regulating pCPA-induced prolactin secretion in estradiol-treated rats.	Fenclonine	210-214	prolactin	Rattus norvegicus	104-113
11456281-3	2001	The aim of the present study was to investigate the ability of estrogen to modify the effect of pCPA on prolactin secretion and to evaluate the participation of opioid and/or dopaminergic systems in regulating pCPA-induced prolactin secretion in estradiol-treated rats.	Fenclonine	210-214	prolactin	Rattus norvegicus	223-232
11456281-4	2001	We observed that pCPA administration (200 mg/kg/day, s.c., 2 days) to ovariectomized (OVX) female rats treated with estradiol benzoate (300 microg/week for 2 weeks, or 50 microg/week for 4 weeks, s.c.) causes a significant increase in serum prolactin, whereas no effect is observed in intact rats or in OVX rats without treatment.	Fenclonine	17-21	prolactin	Rattus norvegicus	241-250
11115741-3	2000	Acute severe serotonin depletion induced by p-chlorophenylalanine (PCPA) treatment leads to enhanced NET(Long) mRNA levels and reduced 5HTT mRNA level.	Fenclonine	44-65	solute carrier family 6 member 2	Homo sapiens	101-104
11334877-2	2001	We examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and tumour necrosis factor (TNF)-alpha secretion following an in vivo lipopolysaccharide challenge.	Fenclonine	140-164	interleukin 1 beta	Rattus norvegicus	196-213
10978755-10	2001	Toxin CM55 produced cutaneous hemorrhage in albino mice, which was also produced in reserpine and p-chloro phenylalanine pretreated animals.	Fenclonine	98-120	Cardiac mass QTL 55	Rattus norvegicus	6-10
11115741-3	2000	Acute severe serotonin depletion induced by p-chlorophenylalanine (PCPA) treatment leads to enhanced NET(Long) mRNA levels and reduced 5HTT mRNA level.	Fenclonine	67-71	solute carrier family 6 member 2	Homo sapiens	101-104
10800950-9	2000	In contrast, pCPA produced a similar effect (87 +/- 5% decrease in TPH activity) only at 10 times the concentration (300 mg/kg).	Fenclonine	13-17	tryptophan hydroxylase 1	Rattus norvegicus	67-70
11063982-5	2000	Immediately after ending PCPA treatment we found increased intracellular S-100beta immunoreactivity in glial cells, reduced 5HT immunolabelling, reduced density of 5HT-T, Nf-200 and Nf-68 fibers and morphological alterations in neuronal cytoskeleton.	Fenclonine	25-29	S100 calcium binding protein B	Rattus norvegicus	73-82
11063982-6	2000	One week after PCPA treatment S-100beta immunoreactivity decreased towards control levels, 5HT was normalized in dorsal raphe nucleus, but not in innervation areas; 5HT-T, Nf-200 and Nf-68 fiber densities increased but some neuronal cytoskeletal alterations were still present in striatum.	Fenclonine	15-19	S100 calcium binding protein B	Rattus norvegicus	30-39
10657025-6	2000	This increase was blocked by pretreatment with the D(1) dopamine receptor antagonist SCH-23390 or with the NMDA glutamate receptor antagonist MK-801, or by lesion of the serotonergic system with 5,7-dihydroxytryptamine or p-chlorophenylalanine.	Fenclonine	222-243	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	107-130
10715571-4	2000	In offspring of both pCPA and 5-MT treated mothers, 5-HT(1A) transcripts were significantly reduced compared to vehicle controls, although effects of pCPA were greater than those of 5-MT.	Fenclonine	21-25	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-59
10715571-5	2000	These results indicate that either under-stimulation of 5-HT(1A) receptors (due to pCPA-induced 5-HT depletion) or over-stimulation (by the agonist 5-MT) during prenatal development significantly reduced expression of 5-HT(1A) receptor transcripts in neonatal offspring.	Fenclonine	83-87	5-hydroxytryptamine receptor 1A	Rattus norvegicus	56-63
10715571-5	2000	These results indicate that either under-stimulation of 5-HT(1A) receptors (due to pCPA-induced 5-HT depletion) or over-stimulation (by the agonist 5-MT) during prenatal development significantly reduced expression of 5-HT(1A) receptor transcripts in neonatal offspring.	Fenclonine	83-87	5-hydroxytryptamine receptor 1A	Rattus norvegicus	218-225
10666140-8	2000	PCPA pretreatment increased dF- and dNF-induced Fos-ir in the PVN, SON, and MnPO.	Fenclonine	0-4	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-51
11450029-0	2000	Spinal cord injury induced c-fos expression is reduced by p-CPA, a serotonin synthesis inhibitor.	Fenclonine	58-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
11450029-5	2000	Pretreatment with p-CPA, a serotonin synthesis inhibitor, significantly attenuated the c-fos upregulation along with the edematous expansion of the cord.	Fenclonine	18-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-92
10921076-1	1997	The spontaneous withdrawal from morphine in morphine-dependent rats significantly decreased the duration of active interaction in social interaction test and the number of licks during the shock-punished period in Vogel"s conflict procedure, which were attenuated by buspirone, a 5-HT1A agonist, as well as para-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase.	Fenclonine	307-331	5-hydroxytryptamine receptor 1A	Rattus norvegicus	280-286
10421712-4	1999	Previously, we reported that serotonin (5-HT) synthesis inhibition by parachlorophenylalanine increases 5-HT(1B) binding site labeling in the SCN.	Fenclonine	70-93	5-hydroxytryptamine receptor 1B	Rattus norvegicus	104-111
9890434-3	1999	Taken that the confocal analysis indicated that serotonin neurons do not express PSA-NCAM and that similar decreases in PSA-NCAM staining were observed after inhibition of 5-HT synthesis induced by parachlorophenylalanine administration, these results suggest that 5-HT may reduce adhesion by acting on PSA-NCAM expression in its environment, and thus facilitate plasticity in adult brain.	Fenclonine	198-221	neural cell adhesion molecule 1	Rattus norvegicus	124-128
9890434-3	1999	Taken that the confocal analysis indicated that serotonin neurons do not express PSA-NCAM and that similar decreases in PSA-NCAM staining were observed after inhibition of 5-HT synthesis induced by parachlorophenylalanine administration, these results suggest that 5-HT may reduce adhesion by acting on PSA-NCAM expression in its environment, and thus facilitate plasticity in adult brain.	Fenclonine	198-221	neural cell adhesion molecule 1	Rattus norvegicus	124-128
9414020-7	1998	Chronic (5,7-dihydroxytryptamine injection, 4 weeks before) or acute (p-chlorophenylalanine injection) lesion of the serotonergic system led to a marked reduction in Fos expression in response to FE (decrease of about 50%).	Fenclonine	70-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-169
9452197-0	1997	p-Chlorophenylalanine and fluoxetine inhibit D-fenfluramine-induced Fos expression in the paraventricular nucleus, cingulate cortex and frontal cortex but not in other forebrain and brainstem regions.	Fenclonine	0-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
10330705-0	1999	[The action of the neurotoxins 5,6-dihydroxytryptamine and p-chlorophenylalanine on the electrical activity parameters of the command neurons during long-term sensitization and learning in the snail].	Fenclonine	59-80	snail family transcriptional repressor 1	Homo sapiens	193-198
9622647-5	1998	After PCPA treatment, decreases in NPY-Ir neurons density (22-40%) and increases in 5-HT1A and 5-HT1B/1D receptor binding sites (20-50%) were distributed in both upper and deeper cortical regions.	Fenclonine	6-10	neuropeptide Y	Rattus norvegicus	35-38
9622647-5	1998	After PCPA treatment, decreases in NPY-Ir neurons density (22-40%) and increases in 5-HT1A and 5-HT1B/1D receptor binding sites (20-50%) were distributed in both upper and deeper cortical regions.	Fenclonine	6-10	5-hydroxytryptamine receptor 1A	Rattus norvegicus	84-90
9622647-5	1998	After PCPA treatment, decreases in NPY-Ir neurons density (22-40%) and increases in 5-HT1A and 5-HT1B/1D receptor binding sites (20-50%) were distributed in both upper and deeper cortical regions.	Fenclonine	6-10	5-hydroxytryptamine receptor 1B	Rattus norvegicus	95-101
9541929-4	1998	The administration of PCPA increased the level of LHRH in the rostral brain region and decrease it in the septal-preoptic region, the effect being more prominent in males.	Fenclonine	22-26	gonadotropin releasing hormone 1	Rattus norvegicus	50-54
10921076-1	1997	The spontaneous withdrawal from morphine in morphine-dependent rats significantly decreased the duration of active interaction in social interaction test and the number of licks during the shock-punished period in Vogel"s conflict procedure, which were attenuated by buspirone, a 5-HT1A agonist, as well as para-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase.	Fenclonine	333-337	5-hydroxytryptamine receptor 1A	Rattus norvegicus	280-286
9017251-8	1996	At 48 h post-QA injection, PPT and PPE mRNAs were markedly reduced within the striatal lesion site of saline/QA and pCPA/QA groups with respect to their contralateral uninjected control sides.	Fenclonine	116-120	tachykinin, precursor 1	Rattus norvegicus	27-30
8891265-4	1996	PPT mRNA levels were raised 90% in posterior striatum (at the level of the globus pallidus) by 48 h post-pCPA injection.	Fenclonine	105-109	tachykinin, precursor 1	Rattus norvegicus	0-3
8764569-1	1996	After a single intraperitoneal injection of the irreversible tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA; 300 mg/kg), there was a rapid down-regulation of serotonin (5-HT) transporter mRNA levels in cell bodies.	Fenclonine	94-115	solute carrier family 6 member 4	Homo sapiens	183-200
8828573-0	1996	Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine.	Fenclonine	168-189	neuropeptide Y	Rattus norvegicus	22-36
8828573-0	1996	Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine.	Fenclonine	168-189	neuropeptide Y	Rattus norvegicus	38-41
8828573-4	1996	This study aimed to determine whether central injection of the 5-HT synthesis inhibitor p-chlorophenylalanine (pCPA), which increases feeding, increased hypothalamic NPY and NPY mRNA levels.	Fenclonine	88-109	neuropeptide Y	Rattus norvegicus	166-169
8828573-4	1996	This study aimed to determine whether central injection of the 5-HT synthesis inhibitor p-chlorophenylalanine (pCPA), which increases feeding, increased hypothalamic NPY and NPY mRNA levels.	Fenclonine	111-115	neuropeptide Y	Rattus norvegicus	166-169
8828573-12	1996	pCPA administration increased NPY levels in several regions notably the PVN.	Fenclonine	0-4	neuropeptide Y	Rattus norvegicus	30-33
8828573-14	1996	We suggest that the hyperphagia induced by pCPA is mediated by increased NPY levels and secretion in the PVN.	Fenclonine	43-47	neuropeptide Y	Rattus norvegicus	73-76
9046080-4	1996	In contrast, the PCPA inhibition of serotonin synthesis in the neurons spared by the partial lesion or the near-complete neurotoxic lesion induced an increase in the number of striatal NPY neurons.	Fenclonine	17-21	neuropeptide Y	Rattus norvegicus	185-188
8857606-13	1996	The increase in PRL at 18.00 h on day 17 induced by E2 was dramatically enhanced by NAL or pCPA, while these treatments did not significantly modify serum P levels.	Fenclonine	91-95	prolactin	Rattus norvegicus	16-19
8764569-1	1996	After a single intraperitoneal injection of the irreversible tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA; 300 mg/kg), there was a rapid down-regulation of serotonin (5-HT) transporter mRNA levels in cell bodies.	Fenclonine	117-121	solute carrier family 6 member 4	Homo sapiens	183-200
8764569-3	1996	Seven days after PCPA treatment, 5-HT transporter mRNA levels were significantly elevated compared with controls in both regions of the dorsal raphe nucleus.	Fenclonine	17-21	solute carrier family 6 member 4	Homo sapiens	33-49
7609623-0	1995	Circadian change of VIP mRNA in the rat suprachiasmatic nucleus following p-chlorophenylalanine (PCPA) treatment in constant darkness.	Fenclonine	74-95	vasoactive intestinal peptide	Rattus norvegicus	20-23
8772497-2	1996	We examined the effect of depletion of endogenous 5-HT by p-chlorophenylalanine (pCPA) on spontaneously and motilin-induced phase III contractions in conscious dogs, and the effect of 5,6-dihydroxytryptamine (5,6-DHT) in an isolated perfused dog stomach.	Fenclonine	81-85	motilin	Canis lupus familiaris	108-115
8772497-3	1996	Three-day treatment with pCPA significantly reduced plasma 5-HT concentration and 5-HT content in the stomach, and strongly suppressed the spontaneous and motilin-induced phase III contractions in the stomach.	Fenclonine	25-29	motilin	Canis lupus familiaris	155-162
9064604-4	1995	In light-phase, total signals of VIP mRNA from the PCPA-treated rats showed a significant decrease compared with those from the saline-treated control rats.	Fenclonine	51-55	vasoactive intestinal peptide	Rattus norvegicus	33-36
8593584-1	1995	In order to study the impact of serotonin depletion on gene expression of the serotonin transporter (5-HTt) we measured 5-HTt mRNA levels by Northern blot in rats treated with p-chlorophenylalanine methyl ester (PCPA) for 10 days.	Fenclonine	212-216	solute carrier family 6 member 4	Rattus norvegicus	101-106
8593584-6	1995	5-HTt mRNA levels decreased to 81.1% (P = 0.05) and 76.0% (P = 0.05) of the control level for PCPA treated animals without and with concomitant imipramine treatment, respectively.	Fenclonine	94-98	solute carrier family 6 member 4	Rattus norvegicus	0-5
8732045-6	1995	SP and For induced c-fos expressions in the spinal cord and the pain responses were reduced by 5-HT and increased by 5-HT depletor fenclonine 300 mg.kg-1.	Fenclonine	131-141	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24
8584751-3	1995	with the TPH inhibitor para-chlorophenylalanine (PCPA; 300 mg/kg).	Fenclonine	23-47	tryptophan hydroxylase 1	Mus musculus	9-12
8584751-6	1995	There was a significant decrease (> 50%) in TPH activity in both the PCPA-treated and antisense-oligo infused animals compared to either scrambled-oligo or saline-infused subjects (ANOVA; P < 0.05).	Fenclonine	72-76	tryptophan hydroxylase 1	Mus musculus	47-50
8544984-5	1995	Two-day pretreatment with p-chlorophenylalanine (300 mg/kg) prior to tranylcypromine and L-tryptophan resulted in a significant attenuation of Fos-like immunoreactivity in specific brain areas, including the piriform and frontal cortices, nucleus accumbens, caudate-putamen, paraventricular hypothalamus and paraventricular thalamic nucleus.	Fenclonine	26-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	143-146
7609623-0	1995	Circadian change of VIP mRNA in the rat suprachiasmatic nucleus following p-chlorophenylalanine (PCPA) treatment in constant darkness.	Fenclonine	97-101	vasoactive intestinal peptide	Rattus norvegicus	20-23
7609623-5	1995	In contrast, in PCPA-treated rats, a significant rhythm of VIP mRNA was observed with a peak at CT 4 and a trough at CT 20.	Fenclonine	16-20	vasoactive intestinal peptide	Rattus norvegicus	59-62
7890297-2	1995	While the proportions of splenic CD4+ and CD8+ T cells isolated from control and PCPA-treated mice were similar, the level of expression of the alpha-chain interleukin-2 receptor (IL-2R) was reduced on splenic CD4+ cells but not on CD8+ cells.	Fenclonine	81-85	interleukin 2 receptor, alpha chain	Mus musculus	180-185
7714755-11	1995	A role of postsynaptic 5-HT1A receptors in the action of 5-HT1A agonists was suggested by the finding that parachlorophenylalanine (3 x 300 mg/kg, i.p.	Fenclonine	107-130	5-hydroxytryptamine receptor 1A	Rattus norvegicus	23-29
7714755-11	1995	A role of postsynaptic 5-HT1A receptors in the action of 5-HT1A agonists was suggested by the finding that parachlorophenylalanine (3 x 300 mg/kg, i.p.	Fenclonine	107-130	5-hydroxytryptamine receptor 1A	Rattus norvegicus	57-63
7753505-0	1995	A serotonin synthesis inhibitor, p-chlorophenylalanine reduces the heat shock protein response following trauma to the spinal cord: an immunohistochemical and ultrastructural study in the rat.	Fenclonine	33-54	selenoprotein K	Rattus norvegicus	67-85
7753505-1	1995	The influence of the serotonin synthesis inhibitor, p-CPA on the expression of the heat shock protein (70 kDa), which occurs around an injury to the rat spinal cord, was examined by immunohistochemistry.	Fenclonine	52-57	selenoprotein K	Rattus norvegicus	83-101
7991577-10	1994	When water-loaded, DRN-lesioned and PCPA-injected animals showed diminished excretion of sodium, accompanied by a decrease in basal plasma ANP concentrations, and blockade of the increase in plasma ANP, which followed blood volume expansion by intraatrial injection of hypertonic saline.	Fenclonine	36-40	natriuretic peptide A	Rattus norvegicus	139-142
7991577-10	1994	When water-loaded, DRN-lesioned and PCPA-injected animals showed diminished excretion of sodium, accompanied by a decrease in basal plasma ANP concentrations, and blockade of the increase in plasma ANP, which followed blood volume expansion by intraatrial injection of hypertonic saline.	Fenclonine	36-40	natriuretic peptide A	Rattus norvegicus	198-201
7991577-12	1994	Therefore, in the absence of this serotoninergic input following destruction of the serotoninergic neurons by DRN lesions or intraventricular injection of PCPA, an antinatriuretic effect is obtained that is associated with increased drinking, either because of sodium retention per se or removal of ANP-induced inhibition of release of the dipsogenic peptide, angiotensin II.	Fenclonine	155-159	natriuretic peptide A	Rattus norvegicus	299-302
7827334-3	1994	Reserpine and parachlorophenylalanine, which elicited a similar increase in the TH content, failed to induce a significant change in the number of TH-expressing cells.	Fenclonine	14-37	tyrosine hydroxylase	Rattus norvegicus	80-82
7531598-4	1994	An up-regulation of 5-HT1B receptors with similar magnitude was obtained in the two parts of the SCN after inhibition of 5-HT synthesis by chronic parachlorophenylalanine treatment.	Fenclonine	147-170	5-hydroxytryptamine receptor 1B	Rattus norvegicus	20-26
7991577-12	1994	Therefore, in the absence of this serotoninergic input following destruction of the serotoninergic neurons by DRN lesions or intraventricular injection of PCPA, an antinatriuretic effect is obtained that is associated with increased drinking, either because of sodium retention per se or removal of ANP-induced inhibition of release of the dipsogenic peptide, angiotensin II.	Fenclonine	155-159	angiotensinogen	Rattus norvegicus	360-374
7970161-0	1994	Serotonin depletion by p-chlorophenylalanine decreases VIP mRNA in the suprachiasmatic nucleus.	Fenclonine	23-44	vasoactive intestinal peptide	Rattus norvegicus	55-58
7942089-3	1994	The content of VIP mRNA was measured in the SCN in fetuses at the 21st embryonic day (E21) and in postnatal rats at day 11 (P11) following chronic depletion of serotonin by p-chlorophenylalanine, an inhibitor of serotonin synthesis.	Fenclonine	173-194	vasoactive intestinal peptide	Rattus norvegicus	15-18
8015380-0	1994	Early induction of rat brain tryptophan hydroxylase (TPH) mRNA following parachlorophenylalanine (PCPA) treatment.	Fenclonine	73-96	tryptophan hydroxylase 1	Rattus norvegicus	29-51
8015380-0	1994	Early induction of rat brain tryptophan hydroxylase (TPH) mRNA following parachlorophenylalanine (PCPA) treatment.	Fenclonine	73-96	tryptophan hydroxylase 1	Rattus norvegicus	53-56
8015380-0	1994	Early induction of rat brain tryptophan hydroxylase (TPH) mRNA following parachlorophenylalanine (PCPA) treatment.	Fenclonine	98-102	tryptophan hydroxylase 1	Rattus norvegicus	29-51
8015380-0	1994	Early induction of rat brain tryptophan hydroxylase (TPH) mRNA following parachlorophenylalanine (PCPA) treatment.	Fenclonine	98-102	tryptophan hydroxylase 1	Rattus norvegicus	53-56
8015380-4	1994	In order to determine whether TPH gene regulation is dependent on the 5-HT concentration, 5-HT levels were reduced by the administration of parachlorophenylalanine (PCPA).	Fenclonine	140-163	tryptophan hydroxylase 1	Rattus norvegicus	30-33
8015380-4	1994	In order to determine whether TPH gene regulation is dependent on the 5-HT concentration, 5-HT levels were reduced by the administration of parachlorophenylalanine (PCPA).	Fenclonine	165-169	tryptophan hydroxylase 1	Rattus norvegicus	30-33
8015380-5	1994	PCPA is a potent, specific and irreversible inhibitor of TPH activity which drastically reduces 5-HT concentration in the 5-HT neurons and terminals.	Fenclonine	0-4	tryptophan hydroxylase 1	Rattus norvegicus	57-60
8015380-6	1994	When PCPA was administered, TPH activity in both cell bodies and nerve terminal areas, was reduced to 10% of control values and recovered to the control levels by day 7 in raphe nucleus, and within 14 days in the hypothalamus.	Fenclonine	5-9	tryptophan hydroxylase 1	Rattus norvegicus	28-31
8298984-4	1993	Thus when 5-HT was reduced by PCPA treatment, S100 beta immunoreactivity was also reduced.	Fenclonine	30-34	S100 calcium binding protein B	Homo sapiens	46-55
7725832-5	1994	In the second series of experiments, the effect of serotonin (5-HT) depletion by the inhibitor of the 5-HT synthesis, p-chlorophenylalanine, on the vasoactive intestinal polypeptide (VIP) mRNA level in the suprachiasmatic nucleus (SCN) has been studied in fetuses and in neonates as described above.	Fenclonine	118-139	vasoactive intestinal peptide	Rattus norvegicus	148-181
8389647-2	1993	We have investigated the effects of serotonin depletion by p-chlorophenyl-alanine (PCPA) on corticotrophin-releasing factor (CRF) mRNA and c-fos mRNA responses in the paraventricular nucleus (PVN) together with circulating levels of ACTH and corticosterone to both physical and psychological stressors in the rat.	Fenclonine	83-87	corticotropin releasing hormone	Rattus norvegicus	92-123
8284251-5	1993	Structure-activity studies with N-alpha-Ac-PYY(22-36) showed that substitution of His26 with parachlorophenylalanine (pCl-Phe) or Tyr36 with N-Me-Tyr reduced receptor affinity, while replacement of Tyr27 with Phe increased the activity substantially.	Fenclonine	93-116	peptide YY	Rattus norvegicus	43-46
8284251-5	1993	Structure-activity studies with N-alpha-Ac-PYY(22-36) showed that substitution of His26 with parachlorophenylalanine (pCl-Phe) or Tyr36 with N-Me-Tyr reduced receptor affinity, while replacement of Tyr27 with Phe increased the activity substantially.	Fenclonine	118-125	peptide YY	Rattus norvegicus	43-46
7508355-2	1993	Birds were injected intraperitoneally with DL-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment.	Fenclonine	43-67	phenylalanine hydroxylase	Gallus gallus	101-126
7508355-2	1993	Birds were injected intraperitoneally with DL-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment.	Fenclonine	69-73	phenylalanine hydroxylase	Gallus gallus	101-126
8229069-4	1993	Parachlorophenylalanine decreased the spinal cord TRH content in C3H mice, while it increased TRH levels in all regions of the RMN spinal cord.	Fenclonine	0-23	thyrotropin releasing hormone	Mus musculus	50-53
8229069-4	1993	Parachlorophenylalanine decreased the spinal cord TRH content in C3H mice, while it increased TRH levels in all regions of the RMN spinal cord.	Fenclonine	0-23	thyrotropin releasing hormone	Mus musculus	94-97
8330675-9	1993	The increased responses in p-CPA-treated rats were mediated via 5-HT2/5-HT1C receptors, while activation of other 5-HT1 receptor subtypes and 5-HT3 receptors induced similar depolarizations in p-CPA-treated and untreated rats.	Fenclonine	27-32	5-hydroxytryptamine receptor 2C	Rattus norvegicus	70-76
8512625-0	1993	The combination of VIP and atropine induces REM sleep in cats rendered insomniac by PCPA.	Fenclonine	84-88	vasoactive intestinal peptide	Felis catus	19-22
8512625-6	1993	Results showed that VIP and atropine injected alone and in combination increased mean total time of REM sleep in PCPA-treated animals.	Fenclonine	113-117	vasoactive intestinal peptide	Felis catus	20-23
8446679-5	1993	The number of head twitches produced by caffeine in 5,7-DHT-treated mice was increased twofold by p-chlorophenylalanine (p-CPA), the tryptophan hydroxylase inhibitor.	Fenclonine	98-119	carboxypeptidase A1, pancreatic	Mus musculus	123-126
7690117-6	1993	Lastly, pretreatment with the 5-HT synthesis inhibitor p-chlorophenylalanine prevented the immediate inhibitory effect of the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) upon cold-induced TSH release, but it amplified the late release of TSH in cold-exposed 8-OH-DPAT-injected rats.	Fenclonine	55-76	5-hydroxytryptamine receptor 1A	Rattus norvegicus	136-142
8389958-3	1993	Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.	Fenclonine	149-173	thyrotropin releasing hormone	Homo sapiens	85-88
8389958-3	1993	Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.	Fenclonine	175-179	thyrotropin releasing hormone	Homo sapiens	85-88
8310791-0	1993	p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord.	Fenclonine	0-21	glial fibrillary acidic protein	Rattus norvegicus	80-111
8310791-8	1993	Pretreatment with p-CPA markedly reduced the GFAP response.	Fenclonine	18-23	glial fibrillary acidic protein	Rattus norvegicus	45-49
8381907-0	1993	Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.	Fenclonine	0-24	vasoactive intestinal peptide	Rattus norvegicus	62-91
8381907-2	1993	Single injections of pCPA (300 mg/kg) for two consecutive days resulted on the third day in a dramatic depletion of serotonin in the medial basal hypothalamus, and a significant reduction in the pituitary content of VIP mRNA (1.0 and 1.7 kb).	Fenclonine	21-25	vasoactive intestinal peptide	Rattus norvegicus	216-219
8381907-3	1993	The effect of pCPA on VIP mRNA appeared to be relatively specific for the anterior pituitary since VIP message levels in the cerebral cortex did not decrease.	Fenclonine	14-18	vasoactive intestinal peptide	Rattus norvegicus	22-25
8381907-5	1993	In a time-course study, hypothalamic serotonin and pituitary VIP mRNA levels were significantly depressed 1-3 days after initiation of pCPA treatment; however, 12 days after pCPA treatment, serotonin concentrations in the hypothalamus approached control values and pituitary VIP mRNA content increased an average of 2-fold over control levels in an apparent rebound effect.	Fenclonine	135-139	vasoactive intestinal peptide	Rattus norvegicus	61-64
8381907-5	1993	In a time-course study, hypothalamic serotonin and pituitary VIP mRNA levels were significantly depressed 1-3 days after initiation of pCPA treatment; however, 12 days after pCPA treatment, serotonin concentrations in the hypothalamus approached control values and pituitary VIP mRNA content increased an average of 2-fold over control levels in an apparent rebound effect.	Fenclonine	174-178	vasoactive intestinal peptide	Rattus norvegicus	61-64
8381907-7	1993	twice a day with 5-hydroxytryptophan (5-HTP; 50 mg/kg) experienced a partial reversal in the decline in the 1.7 kb VIP mRNA seen 24 h after the first pCPA injection.	Fenclonine	150-154	vasoactive intestinal peptide	Rattus norvegicus	115-118
1448481-0	1992	5-HT3 receptor antagonists block cocaine-induced locomotion via a PCPA-sensitive mechanism.	Fenclonine	66-70	5-hydroxytryptamine receptor 3A	Rattus norvegicus	0-14
1475314-5	1992	An administration of p-chlorophenylalanine, an irreversible inhibitor of TPH, decreased the duration of freezing in cataleptic rats.	Fenclonine	21-42	tryptophan hydroxylase 1	Rattus norvegicus	73-76
1439079-5	1992	The ARP experimented remarkable rises in the normal and hypertensive rats, these values increasing after L-5HTP and falling after p-CPA and 5-6 DHT injections.	Fenclonine	130-135	kidney androgen regulated protein	Rattus norvegicus	4-7
1383865-0	1992	The effect of p-chloroamphetamine and p-chlorophenylalanine on the level of thyrotropin-releasing hormone and its receptors in some brain structures and lumbar spinal cord of the rat.	Fenclonine	38-59	thyrotropin releasing hormone	Rattus norvegicus	76-105
1383865-2	1992	PCA (2 x 10 mg/kg i.p., 9 and 8 d before killing) and PCPA (3 x 300 mg/kg i.p., 72, 48 and 24 h before killing)--either of them dramatically diminishing the 5-HT and 5-HIAA concentrations in all the examined structures--reduced the TRH level and increased the density of TRH receptors in the ventral lumbar spinal cord.	Fenclonine	54-58	thyrotropin releasing hormone	Rattus norvegicus	232-235
1383865-2	1992	PCA (2 x 10 mg/kg i.p., 9 and 8 d before killing) and PCPA (3 x 300 mg/kg i.p., 72, 48 and 24 h before killing)--either of them dramatically diminishing the 5-HT and 5-HIAA concentrations in all the examined structures--reduced the TRH level and increased the density of TRH receptors in the ventral lumbar spinal cord.	Fenclonine	54-58	thyrotropin releasing hormone	Rattus norvegicus	271-274
1383865-3	1992	PCPA also reduced the TRH content in the nucleus accumbens.	Fenclonine	0-4	thyrotropin releasing hormone	Rattus norvegicus	22-25
1448177-2	1992	The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals.	Fenclonine	199-220	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
1387579-0	1992	Effect of atropine and PCPA on the behavioral modulation of paired-pulse response in the hippocampal CA1 region.	Fenclonine	23-27	carbonic anhydrase 1	Rattus norvegicus	101-104
1944771-5	1991	Although essentially no hydrogen peroxide is formed during the fully coupled oxidation of tetrahydrobiopterin or 6-methyltetrahydropterin by phenylalanine hydroxylase when phenylalanine is the amino acid substrate, significant amounts of hydrogen peroxide are formed during the partially uncoupled oxidation of 6-methyltetrahydropterin when para-fluorophenylalanine or para-chlorophenylalanine are used in place of phenylalanine.	Fenclonine	369-393	phenylalanine hydroxylase	Homo sapiens	141-166
1545496-2	1992	The hypoalgesia caused by PGD2 was blocked by para-chlorophenylalanine, cyproheptadine or phenoxybenzamine.	Fenclonine	46-70	prostaglandin D2 synthase (brain)	Mus musculus	26-30
1667428-8	1991	Similar reduction in the affinity of TRH binding was observed after depletion of brain serotonin with p-chlorophenylalanine (PCPA), which was earlier shown to antagonize the TRH-induced pressor effect.	Fenclonine	125-129	thyrotropin releasing hormone	Rattus norvegicus	174-177
1715540-5	1991	PCPA pretreatment significantly attenuated the pressor effect and the tachycardia induced by TRH, whereas PCA did not modify the effects of TRH, which may be related to its weaker capacity to deplete 5-HT in TRH sensitive brain areas.	Fenclonine	0-4	thyrotropin releasing hormone	Rattus norvegicus	93-96
1826188-1	1991	Rats were pretreated with p-chlorophenylalanine (PCPA) to inhibit hepatic phenylalanine hydroxylase.	Fenclonine	26-47	phenylalanine hydroxylase	Rattus norvegicus	74-99
1713119-2	1991	Depletion of 5-HT with subchronic p-chlorophenylalanine (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS.	Fenclonine	34-55	tachykinin, precursor 1	Rattus norvegicus	83-99
1713119-2	1991	Depletion of 5-HT with subchronic p-chlorophenylalanine (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS.	Fenclonine	34-55	tachykinin, precursor 1	Rattus norvegicus	101-104
1713119-2	1991	Depletion of 5-HT with subchronic p-chlorophenylalanine (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS.	Fenclonine	57-61	tachykinin, precursor 1	Rattus norvegicus	83-99
1713119-2	1991	Depletion of 5-HT with subchronic p-chlorophenylalanine (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS.	Fenclonine	57-61	tachykinin, precursor 1	Rattus norvegicus	101-104
1826188-1	1991	Rats were pretreated with p-chlorophenylalanine (PCPA) to inhibit hepatic phenylalanine hydroxylase.	Fenclonine	49-53	phenylalanine hydroxylase	Rattus norvegicus	74-99
1971022-6	1990	Depletion of brain 5-HT (greater than 80%) by either para-chlorophenylalanine or 5,7-dihydroxytryptamine eliminated the rate-dependent nature of quinpirole-induced inhibition of nigrostriatal DA neurons, while having limited effects on the basal electrophysiological activity of these cells.	Fenclonine	53-77	POU class 6 homeobox 1	Rattus norvegicus	13-20
2267473-2	1990	Recently it has been shown that vasoactive intestinal polypeptide (VIP) may be a specific REM inductor in the parachlorophenylalanine (PCPA) insomniac model.	Fenclonine	110-133	vasoactive intestinal peptide	Felis catus	32-65
2267473-2	1990	Recently it has been shown that vasoactive intestinal polypeptide (VIP) may be a specific REM inductor in the parachlorophenylalanine (PCPA) insomniac model.	Fenclonine	110-133	vasoactive intestinal peptide	Felis catus	67-70
2267473-2	1990	Recently it has been shown that vasoactive intestinal polypeptide (VIP) may be a specific REM inductor in the parachlorophenylalanine (PCPA) insomniac model.	Fenclonine	135-139	vasoactive intestinal peptide	Felis catus	32-65
2267473-2	1990	Recently it has been shown that vasoactive intestinal polypeptide (VIP) may be a specific REM inductor in the parachlorophenylalanine (PCPA) insomniac model.	Fenclonine	135-139	vasoactive intestinal peptide	Felis catus	67-70
1696545-0	1990	p-chlorophenylalanine attenuates the pituitary-adrenocortical response to 5-HT1A receptor agonists in mice.	Fenclonine	0-21	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	74-89
1667428-8	1991	Similar reduction in the affinity of TRH binding was observed after depletion of brain serotonin with p-chlorophenylalanine (PCPA), which was earlier shown to antagonize the TRH-induced pressor effect.	Fenclonine	102-123	thyrotropin releasing hormone	Rattus norvegicus	37-40
1667428-8	1991	Similar reduction in the affinity of TRH binding was observed after depletion of brain serotonin with p-chlorophenylalanine (PCPA), which was earlier shown to antagonize the TRH-induced pressor effect.	Fenclonine	102-123	thyrotropin releasing hormone	Rattus norvegicus	174-177
1667428-8	1991	Similar reduction in the affinity of TRH binding was observed after depletion of brain serotonin with p-chlorophenylalanine (PCPA), which was earlier shown to antagonize the TRH-induced pressor effect.	Fenclonine	125-129	thyrotropin releasing hormone	Rattus norvegicus	37-40
1698245-2	1990	Adult rats received p-chlorophenylalanine (pCPA), an irreversible inhibitor of tryptophan hydroxylase (TPH), via Alzet minipumps.	Fenclonine	20-41	tryptophan hydroxylase 1	Rattus norvegicus	79-101
1698245-2	1990	Adult rats received p-chlorophenylalanine (pCPA), an irreversible inhibitor of tryptophan hydroxylase (TPH), via Alzet minipumps.	Fenclonine	20-41	tryptophan hydroxylase 1	Rattus norvegicus	103-106
1698245-2	1990	Adult rats received p-chlorophenylalanine (pCPA), an irreversible inhibitor of tryptophan hydroxylase (TPH), via Alzet minipumps.	Fenclonine	43-47	tryptophan hydroxylase 1	Rattus norvegicus	79-101
1698245-2	1990	Adult rats received p-chlorophenylalanine (pCPA), an irreversible inhibitor of tryptophan hydroxylase (TPH), via Alzet minipumps.	Fenclonine	43-47	tryptophan hydroxylase 1	Rattus norvegicus	103-106
1698245-5	1990	The pCPA-induced increase was specific for PPT mRNA since no change was detected in mRNA coding for neuron-specific enolase (NSE; a constitutive neuronal protein) or 28 S ribosomal RNA.	Fenclonine	4-8	tachykinin, precursor 1	Rattus norvegicus	43-46
1698245-7	1990	In pCPA-treated litters TPH activity was decreased by 60-70% from E16 to postnatal day 3 (P3), returning to control levels by P8.	Fenclonine	3-7	tryptophan hydroxylase 1	Rattus norvegicus	24-27
1698245-9	1990	Infusion of pCPA for one week resulted in an earlier increase in PPT mRNA levels, suggesting that birth was not required to elicit the surge in PPT message.	Fenclonine	12-16	tachykinin, precursor 1	Rattus norvegicus	65-68
19210386-5	1990	Parachlorophenylalanine (300 mg/kg), a 5-HT synthesis inhibitor, however, caused a marked enhancement of PRL release induced by GAL, which was partially inhibited by a 5-HT neurotoxin, 5, 6-dihydroxytryptamine.	Fenclonine	0-23	prolactin	Rattus norvegicus	105-108
19210386-5	1990	Parachlorophenylalanine (300 mg/kg), a 5-HT synthesis inhibitor, however, caused a marked enhancement of PRL release induced by GAL, which was partially inhibited by a 5-HT neurotoxin, 5, 6-dihydroxytryptamine.	Fenclonine	0-23	galanin and GMAP prepropeptide	Rattus norvegicus	128-131
19210386-6	1990	Parachlorophenylalanine also caused a potentiation of 5-HT-induced PRL release, possibly by sensitizing 5-HT receptors.	Fenclonine	0-23	prolactin	Rattus norvegicus	67-70
33974061-10	2021	In the central IC, cFos+ density was higher following fenfluramine treatment than saline, and lower following pCPA treatment than fenfluramine.	Fenclonine	110-114	FBJ osteosarcoma oncogene	Mus musculus	19-23
2151605-1	1990	Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney.	Fenclonine	48-71	renin	Rattus norvegicus	241-246
2151605-1	1990	Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney.	Fenclonine	73-77	renin	Rattus norvegicus	241-246
1704824-13	1990	Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline 1 day before the collection of pancreatic amylase in Experiment 4.	Fenclonine	43-67	phenylalanine hydroxylase	Gallus gallus	101-126
1704824-13	1990	Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline 1 day before the collection of pancreatic amylase in Experiment 4.	Fenclonine	69-73	phenylalanine hydroxylase	Gallus gallus	101-126
2144886-10	1990	Two injections of PCPA but not one abolished the N PRL surge.	Fenclonine	18-22	prolactin	Rattus norvegicus	51-54
34884655-10	2021	Pargyline reduced Creb, Bdnf and Ntrk2a genes mRNA concentration only in the zebrafish treated with pCPA.	Fenclonine	100-104	brain-derived neurotrophic factor	Danio rerio	24-28
34884655-10	2021	Pargyline reduced Creb, Bdnf and Ntrk2a genes mRNA concentration only in the zebrafish treated with pCPA.	Fenclonine	100-104	neurotrophic tyrosine kinase, receptor, type 2a	Danio rerio	33-39
34285037-8	2021	Silencing TPH1 or HTR3A by shRNA slowed down tumor growth in an established CT26 and iBMDM co-implanted subcutaneous allograft CRC mouse model, whereas treatment with TPH1 inhibitor 4-chloro-DL-phenylalanine (pCPA) or HTR3A antagonist tropisetron (TPS) alleviated tumor progression in an AOM/DSS-induced CRC mouse model.	Fenclonine	209-213	tryptophan hydroxylase 1	Mus musculus	167-171
34285037-8	2021	Silencing TPH1 or HTR3A by shRNA slowed down tumor growth in an established CT26 and iBMDM co-implanted subcutaneous allograft CRC mouse model, whereas treatment with TPH1 inhibitor 4-chloro-DL-phenylalanine (pCPA) or HTR3A antagonist tropisetron (TPS) alleviated tumor progression in an AOM/DSS-induced CRC mouse model.	Fenclonine	182-207	tryptophan hydroxylase 1	Mus musculus	167-171
34432783-0	2021	(Decrease in the Activity of Striatal-Enriched Protein-Tyrosine-Phosphatase (STEP) in the Brain of Danio rerio Treated with p-Chlorophenylalanine and Pargyline).	Fenclonine	124-145	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	77-81
34432783-4	2021	Reduction or elevation of the serotonin level in the brain of mice caused by the administration of p-chlorophenylalanine or pargyline, respectively, results in a decrease in the level of ptpn5 mRNA in the striatum, ptpn5 being the gene encoding STEP.	Fenclonine	99-120	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	187-192
34432783-4	2021	Reduction or elevation of the serotonin level in the brain of mice caused by the administration of p-chlorophenylalanine or pargyline, respectively, results in a decrease in the level of ptpn5 mRNA in the striatum, ptpn5 being the gene encoding STEP.	Fenclonine	99-120	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	215-220
34432783-4	2021	Reduction or elevation of the serotonin level in the brain of mice caused by the administration of p-chlorophenylalanine or pargyline, respectively, results in a decrease in the level of ptpn5 mRNA in the striatum, ptpn5 being the gene encoding STEP.	Fenclonine	99-120	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	245-249
34432783-9	2021	Both p-chlorophenylalanine and pargyline decrease STEP activity in the D. rerio brain, without affecting the level of the ptpn5 mRNA gene.	Fenclonine	5-26	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	50-54
2479530-10	1989	Pretreatment with the same dose of PCPA (24 h), KET (2 h), or LY-53857 (2 h) that was given to rats in the N surge study significantly (P less than 0.01) reduced plasma PRL levels.	Fenclonine	35-39	prolactin	Rattus norvegicus	169-172
34376134-14	2022	Pretreatment with pCPA (5-HT synthesis inhibitor) and NMDA (an agonist of the glutamate site) effectively reversed the immobility time of total sterols and stigmasterol (except pCPA) in TST.	Fenclonine	18-22	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	186-189
2572692-3	1989	Pretreatment of rats with parachlorophenylalanine (p-CPA) did not alter basal gastric acid and serotonin secretion but produced a 57% reduction in the intraluminal gastric release of serotonin and a 43 to 100% potentiation of the gastric acid secretory response elicited by intracisternal injection of the stable thyrotropin-releasing hormone analog, RX 77368, in conscious pylorus-ligated rats or urethane-anesthetized rats with an acute gastric fistula.	Fenclonine	26-49	thyrotropin releasing hormone	Rattus norvegicus	313-342
2530476-0	1989	Tryptophan hydroxylase activity in hypothalamus and brainstem of neonatal and adult rats treated with hydrocortisone or parachlorophenylalanine.	Fenclonine	120-143	tryptophan hydroxylase 1	Rattus norvegicus	0-22
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	79-102	tryptophan hydroxylase 1	Rattus norvegicus	112-134
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	79-102	tryptophan hydroxylase 1	Rattus norvegicus	154-176
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	79-102	tryptophan hydroxylase 1	Rattus norvegicus	178-181
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	104-108	tryptophan hydroxylase 1	Rattus norvegicus	112-134
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	104-108	tryptophan hydroxylase 1	Rattus norvegicus	154-176
2530476-1	1989	The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats.	Fenclonine	104-108	tryptophan hydroxylase 1	Rattus norvegicus	178-181
2530476-2	1989	Our results show that: (1) administration of hydrocortisone causes small but significant increases in TPH activity of neonatal brainstem: (2) treatment with PCPA plus glucocorticoid results in a marked decrease of TPH activity in brainstem and hypothalamus of both neonatal and adult rats.	Fenclonine	157-161	tryptophan hydroxylase 1	Rattus norvegicus	102-105
2530476-2	1989	Our results show that: (1) administration of hydrocortisone causes small but significant increases in TPH activity of neonatal brainstem: (2) treatment with PCPA plus glucocorticoid results in a marked decrease of TPH activity in brainstem and hypothalamus of both neonatal and adult rats.	Fenclonine	157-161	tryptophan hydroxylase 1	Rattus norvegicus	214-217
2471111-2	1989	The antinociceptive effect of substance P, given intraventricularly, in rats and mice was blocked after depletion of 5-HT in the spinal cord with the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or with the inhibitor of the synthesis of 5-HT, p-chlorophenylalanine (PCPA), but not after depletion of NA in the spinal cord with the neurotoxin 6-hydroxydopamine (6-OHDA).	Fenclonine	243-264	tachykinin 1	Mus musculus	30-41
2471111-2	1989	The antinociceptive effect of substance P, given intraventricularly, in rats and mice was blocked after depletion of 5-HT in the spinal cord with the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or with the inhibitor of the synthesis of 5-HT, p-chlorophenylalanine (PCPA), but not after depletion of NA in the spinal cord with the neurotoxin 6-hydroxydopamine (6-OHDA).	Fenclonine	266-270	tachykinin 1	Mus musculus	30-41
2523524-3	1989	Both 5-HT immunoreactivity and TPH activity were decreased in ganglia from animals treated with glucocorticoid and the TPH inhibitor parachlorophenylalanine, but not in animals treated with 5-HT uptake inhibitor fluoxetine.	Fenclonine	133-156	tryptophan hydroxylase 1	Rattus norvegicus	31-34
2523524-3	1989	Both 5-HT immunoreactivity and TPH activity were decreased in ganglia from animals treated with glucocorticoid and the TPH inhibitor parachlorophenylalanine, but not in animals treated with 5-HT uptake inhibitor fluoxetine.	Fenclonine	133-156	tryptophan hydroxylase 1	Rattus norvegicus	119-122
2529739-1	1989	Serotonin (5-HT) depletion with p-chlorophenylalanine (p-CPA) (3 X 150 mg/kg/12 h i.p.)	Fenclonine	32-53	carboxypeptidase A1	Homo sapiens	57-60
2572692-3	1989	Pretreatment of rats with parachlorophenylalanine (p-CPA) did not alter basal gastric acid and serotonin secretion but produced a 57% reduction in the intraluminal gastric release of serotonin and a 43 to 100% potentiation of the gastric acid secretory response elicited by intracisternal injection of the stable thyrotropin-releasing hormone analog, RX 77368, in conscious pylorus-ligated rats or urethane-anesthetized rats with an acute gastric fistula.	Fenclonine	51-56	thyrotropin releasing hormone	Rattus norvegicus	313-342
2975336-2	1988	The results of this investigation revealed that 4.5 microns/10 g p-chlorophenylalanine is more effective than L-phenylalanine, alpha-methylphenylalanine, trimethoprim, Bactrim and Septra, since the former compound produced both adequate hyperphenylalaninemia and marked inhibition of hepatic phenylalanine hydroxylase activity.	Fenclonine	65-86	phenylalanine hydroxylase	Rattus norvegicus	292-317
2532888-2	1989	A decrease in prolactin concentration was measured, from day 3, in 3 out of the 5 birds treated with 100 mg PCPA/kg body weight (BW) for 3 consecutive days.	Fenclonine	108-112	prolactin	Gallus gallus	14-23
2532888-7	1989	However, the reductions in the plasma concentration of prolactin induced by PCPA were not sufficient to restore the hypothalamic-hypophyseal-ovarian axis to a physiological status characteristic of the laying hen.	Fenclonine	76-80	prolactin	Gallus gallus	55-64
2949745-1	1987	P-chlorophenylalanine is an irreversible inhibitor of rat phenylalanine hydroxylase in vivo and in rat hepatoma cells and is frequently administered to rodents to create an animal model for phenylketonuria.	Fenclonine	0-21	phenylalanine hydroxylase	Rattus norvegicus	58-83
2465667-1	1988	The behavioural response to intrathecally injected substance P (SP, 1.25 ng) was investigated in mice after lesioning of serotonergic (5-HT) pathways by intracerebroventricular 5,7-dihydroxytryptamine (5,7-DHT, 80 micrograms base/mouse) and after 5-HT synthesis inhibition by p-chlorophenylalanine (PCPA, 400 mg kg-1 for 6 consecutive days).	Fenclonine	276-297	tachykinin 1	Mus musculus	51-62
2465667-1	1988	The behavioural response to intrathecally injected substance P (SP, 1.25 ng) was investigated in mice after lesioning of serotonergic (5-HT) pathways by intracerebroventricular 5,7-dihydroxytryptamine (5,7-DHT, 80 micrograms base/mouse) and after 5-HT synthesis inhibition by p-chlorophenylalanine (PCPA, 400 mg kg-1 for 6 consecutive days).	Fenclonine	299-303	tachykinin 1	Mus musculus	51-62
3387454-3	1988	Moreover, [met]enkephalin plasma concentrations were significantly decreased in rats treated with drug affecting the serotoninergic system such as reserpine, 5,7-dihydroxytryptamine or parachlorophenylalanine, while depletion of the catecholaminergic system by alfa-methyl-thyrosine did not affect the concentrations of the peptide.	Fenclonine	185-208	proenkephalin	Rattus norvegicus	15-25
2974880-0	1988	Inhibition of p-chlorophenylalanine-induced muricide behavior following TRH microinjection into the limbic structures in the rat.	Fenclonine	14-35	thyrotropin releasing hormone	Rattus norvegicus	72-75
2959466-10	1987	The results indirectly show that pCPA-induced suppression of renal renin secretion observed in Wi rats may be due to prevailing inhibitory action of antidiuretic hormone.	Fenclonine	33-37	renin	Rattus norvegicus	67-72
2957619-0	1987	Cerebroventricular infusion of cholecystokinin (CCK-8) restores REM sleep in parachlorophenylalanine (PCPA)-pretreated cats.	Fenclonine	77-100	cholecystokinin	Felis catus	31-46
2957619-0	1987	Cerebroventricular infusion of cholecystokinin (CCK-8) restores REM sleep in parachlorophenylalanine (PCPA)-pretreated cats.	Fenclonine	102-106	cholecystokinin	Felis catus	31-46
2449537-6	1987	However, if, prior to nerve resection, serotonin stores are depleted by p-chlorophenylalanine treatment, the damage to met-enkephalin interneurons is fully prevented, while substance P loss does still occur.	Fenclonine	72-93	proopiomelanocortin	Homo sapiens	119-133
2946301-10	1986	PCPA, DHT, AMPT and 6-OHDA did not have any effect by themselves on adrenal PNMT, but the combination of PCPA and AMPT, each given i.p., caused increased adrenal PNMT activity.	Fenclonine	105-109	phenylethanolamine-N-methyltransferase	Rattus norvegicus	162-166
3666036-6	1987	Persistence of the anorexic effect of RU 24969 after p-chlorophenylalanine (pCPA) pretreatment suggests that 5-HT1B agonists induce anorexia at a postsynaptic 5-HT receptor.	Fenclonine	76-80	5-hydroxytryptamine receptor 1B	Rattus norvegicus	109-115
3035083-2	1987	In the present study it is shown that the GH response to clonidine is weaker in rats exposed to depletion of both noradrenaline and serotonin (by means of reserpine or the combined treatment of FLA-63 and PCPA) than in animals exposed to noradrenaline depletion (by means of FLA-63) only.	Fenclonine	205-209	gonadotropin releasing hormone receptor	Rattus norvegicus	42-44
2949745-2	1987	We investigated the effect of p-chlorophenylalanine on production of human phenylalanine hydroxylase in human hepatoma cells and cells transformed with the recombinant human phenylalanine hydroxylase gene.	Fenclonine	30-51	phenylalanine hydroxylase	Homo sapiens	75-100
3030046-5	1986	Similar changes were observed in SCN rats 24 hours after water deprivation and in intact rats 48 hours after serotonin depletion by pCPA: suppressed renin activity together with increased aldosterone concentration.	Fenclonine	132-136	renin	Rattus norvegicus	149-154
2945620-4	1986	The purpose of this study is to determine whether the CSF of sleep-deprived cats and VIP can reverse insomnia produced by parachlorophenylalanine (PCPA).	Fenclonine	122-145	vasoactive intestinal peptide	Felis catus	85-88
2945620-4	1986	The purpose of this study is to determine whether the CSF of sleep-deprived cats and VIP can reverse insomnia produced by parachlorophenylalanine (PCPA).	Fenclonine	147-151	vasoactive intestinal peptide	Felis catus	85-88
2938024-5	1986	p-Chlorophenylalanine (intraperitoneal) or 5,7-dihydroxytryptamine (intracerebroventricular or injected into the medial raphe nucleus) increases the effect of reserpine, but the use of a catecholamine-depleting agent with reserpine does not alter the increase of adrenal dopamine beta-hydroxylase obtained with reserpine alone.	Fenclonine	0-21	dopamine beta-hydroxylase	Rattus norvegicus	271-296
2931284-6	1985	5,7-DHT and PCPA pretreatment decreased forebrain 5-HT content and prevented ADH increases involved by water deprivation, suggesting that 5HT is necessary for the hormonal response to osmotic stimuli.	Fenclonine	12-16	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	77-80
3900613-3	1985	Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus.	Fenclonine	181-202	renin	Rattus norvegicus	117-122
3900613-3	1985	Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus.	Fenclonine	204-208	renin	Rattus norvegicus	117-122
3157761-8	1985	Daily treatment with parachlorophenylalanine, an inhibitor of serotonin synthesis, reduced the hypothalamic release of TRH by 50%, but did not prevent the afternoon surge of prolactin and TRH induced by oestradiol benzoate.	Fenclonine	21-44	thyrotropin releasing hormone	Rattus norvegicus	119-122
3156202-4	1985	These results show that (i) PCPA can block the pro-oestrous prolactin as well as the LH surge, (ii) in addition to a central action PCPA may depend also on its peripheral effect on the secretion of oestradiol-17 beta and (iii) on average, lower plasma concentrations of oestradiol-17 beta are required for triggering the prolactin compared with the LH surge.	Fenclonine	28-32	prolactin	Rattus norvegicus	321-330
3156202-0	1985	Parachlorophenylalanine blocks the spontaneous pro-oestrous surge of prolactin as well as LH and affects the secretion of oestradiol-17 beta.	Fenclonine	0-23	prolactin	Rattus norvegicus	69-78
3156202-1	1985	The effect of the 5-hydroxytryptamine synthesis inhibitor, parachlorophenylalanine (PCPA), on the spontaneous, pro-oestrous surges of prolactin and LH was investigated in conscious female rats implanted with an intra-atrial cannula.	Fenclonine	59-82	prolactin	Rattus norvegicus	134-143
3156202-1	1985	The effect of the 5-hydroxytryptamine synthesis inhibitor, parachlorophenylalanine (PCPA), on the spontaneous, pro-oestrous surges of prolactin and LH was investigated in conscious female rats implanted with an intra-atrial cannula.	Fenclonine	84-88	prolactin	Rattus norvegicus	134-143
6150877-9	1984	The serotonin synthesis blocker, parachlorophenylalanine (pCPA; 100 mg/kg), nonsignificantly reduced PRL cell nuclear area.	Fenclonine	33-56	prolactin	Oncorhynchus mykiss	101-104
2427964-8	1986	The enhancing effect of Tp on PRL secretion was antagonized by chronic treatment with p-chlorophenylalanine, while it was also maintained in 5,7-dihydroxytryptamine-lesioned rats.	Fenclonine	86-107	prolactin	Rattus norvegicus	30-33
6150877-9	1984	The serotonin synthesis blocker, parachlorophenylalanine (pCPA; 100 mg/kg), nonsignificantly reduced PRL cell nuclear area.	Fenclonine	58-62	prolactin	Oncorhynchus mykiss	101-104
6396524-1	1984	The increase in plasma renin activity produced by p-chloroamphetamine in unanesthetized rats is blocked by p-chlorophenylalanine and by lesions of the dorsal raphe nucleus and the mediobasal hypothalamus.	Fenclonine	107-128	renin	Rattus norvegicus	23-28
6204342-3	1984	An experimental decrease of brain 5-HT level by inhibition of its biosynthesis by p-chlorophenylalanine (200 mg/kg) induced the sleep-like state of catatonic type, i.e., the state which was characterized by lowered brain 5-HT.	Fenclonine	82-103	POU class 6 homeobox 1	Homo sapiens	28-35
6235457-6	1984	The activity of acid DNase was reduced in both cerebellum and cerebrum from 11 as well as 21 day old rats treated with PCPA plus PHE, but the enzyme activity was not altered in the tissues from rats of both ages treated with alpha MPA plus PHE.	Fenclonine	119-123	deoxyribonuclease 2, lysosomal	Rattus norvegicus	16-26
6232468-0	1984	The effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine on thyrotrophin-releasing hormone in regions of the brain and spinal cord of the rat.	Fenclonine	43-64	thyrotropin releasing hormone	Rattus norvegicus	68-98
6232468-10	1984	p-Chlorophenylalanine also significantly reduced levels of TRH in the nucleus accumbens (-72%) but not in the other regions of brain or spinal cord taken.	Fenclonine	0-21	thyrotropin releasing hormone	Rattus norvegicus	59-62
6227473-11	1983	Administration of p-chlorophenylalanine, a drug which reduces serotonin synthesis, was followed by a significant decline in the indole content of a portion of the brain which included the brain stem, the hypothalamus, and the preopticsuprachiasmatic area; and by a blockade of the PRL-releasing effect of cimetidine.	Fenclonine	18-39	prolactin	Rattus norvegicus	281-284
6196082-5	1983	Inhibition of serotonin biosynthesis by PCPA increased by 90% the substance P content in the dorsal horn of euthyroid rats and abolished completely the stimulatory effect of hypothyroidism on the TRH content of the ventral horn.	Fenclonine	40-44	thyrotropin releasing hormone	Rattus norvegicus	196-199
6418248-3	1983	The response to LM 5008 after monoamine oxidase (MAO) inhibition was abolished by pretreatment with p-chlorophenylalanine, indicating the involvement of 5-HT in producing the hyperactivity syndrome.	Fenclonine	100-121	monoamine oxidase A	Rattus norvegicus	49-52
6222783-2	1983	On the contrary, the administration of PCPA during a 48 h sleep deprivation is followed by a great decrease of light slow wave sleep (SWS1) and by total disappearance of SWS2 while some rebound of PS still occurs in narcoleptic-like attacks.	Fenclonine	39-43	zinc finger SWIM-type containing 7	Homo sapiens	134-138
6222783-2	1983	On the contrary, the administration of PCPA during a 48 h sleep deprivation is followed by a great decrease of light slow wave sleep (SWS1) and by total disappearance of SWS2 while some rebound of PS still occurs in narcoleptic-like attacks.	Fenclonine	39-43	EF-hand domain family member D1	Homo sapiens	170-174
6222267-7	1983	Phenylethanolamine N-methyltransferase, the enzyme responsible for converting noradrenaline to adrenaline, is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite, p-chlorophenylethylamine.	Fenclonine	143-164	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6294278-8	1983	Nevertheless, the PRL-releasing effect of YOH was potentiated 24 hr after the administration of reserpine or para-chlorophenylalanine, an inhibitor of serotonin synthesis.	Fenclonine	109-133	prolactin	Rattus norvegicus	18-21
3156202-4	1985	These results show that (i) PCPA can block the pro-oestrous prolactin as well as the LH surge, (ii) in addition to a central action PCPA may depend also on its peripheral effect on the secretion of oestradiol-17 beta and (iii) on average, lower plasma concentrations of oestradiol-17 beta are required for triggering the prolactin compared with the LH surge.	Fenclonine	28-32	prolactin	Rattus norvegicus	60-69
6147008-15	1984	On the other hand, transfer of CSF from a normal sleep deprived donor cat induces PS in a PCPA pretreated insomniac recipient cat.	Fenclonine	90-94	colony stimulating factor 2	Homo sapiens	31-34
6227192-3	1983	Treatment with para-chlorophenylalanine (PCPA, 100 mg/kg) reduced the brain serotonin content and the level of plasma prolactin.	Fenclonine	15-39	prolactin	Gallus gallus	118-127
6227192-3	1983	Treatment with para-chlorophenylalanine (PCPA, 100 mg/kg) reduced the brain serotonin content and the level of plasma prolactin.	Fenclonine	41-45	prolactin	Gallus gallus	118-127
6227192-5	1983	The in vitro responsiveness of the pituitary gland to hypothalamic stimuli eliciting prolactin secretion was increased by in vivo pargyline and combined tryptophan: imipramine treatment but reduced by PCPA administration.	Fenclonine	201-205	prolactin	Gallus gallus	85-94
6218542-2	1982	In both experimental groups, results showed that administration of PCPA caused an increase in both prolactin concentration and number of mature ovarian follicles (p less than 0.001).	Fenclonine	67-71	prolactin	Rattus norvegicus	99-108
6204342-3	1984	An experimental decrease of brain 5-HT level by inhibition of its biosynthesis by p-chlorophenylalanine (200 mg/kg) induced the sleep-like state of catatonic type, i.e., the state which was characterized by lowered brain 5-HT.	Fenclonine	82-103	POU class 6 homeobox 1	Homo sapiens	215-222
6217479-8	1982	Acute or chronic treatment with PCPA increased behavior suppressed by punishment, but this effect was weak, brief, and poorly related to the depletion of brain 5-HT.	Fenclonine	32-36	POU class 6 homeobox 1	Rattus norvegicus	154-161
6219431-2	1982	The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated.	Fenclonine	104-125	procollagen C-endopeptidase enhancer	Rattus norvegicus	20-44
6219431-2	1982	The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated.	Fenclonine	104-125	procollagen C-endopeptidase enhancer	Rattus norvegicus	46-50
6219431-2	1982	The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated.	Fenclonine	127-131	procollagen C-endopeptidase enhancer	Rattus norvegicus	20-44
6219431-2	1982	The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated.	Fenclonine	127-131	procollagen C-endopeptidase enhancer	Rattus norvegicus	46-50
6457138-3	1981	p-Chlorophenylalanine decreased plasma renin activity and p-chlorophenylalanine plus 5-hydroxytryptophan increased plasma renin activity.	Fenclonine	0-21	renin	Rattus norvegicus	39-44
6455729-1	1981	Dogs were fed a continuous diet of phenylalanine (Phe) daily and para-chloro-phenylalanine (p-CPhe), an inhibitor of phenylalanine hydroxylase (PH-ase) every second day.	Fenclonine	65-90	phenylalanine hydroxylase	Canis lupus familiaris	144-150
7274094-1	1981	Maternal treatment with p-chlorophenylalanine strongly inhibits brain tryptophan hydroxylase (TPH) activity in the embryo, whereas administration of tryptophan significantly elevates the activity of this enzyme.	Fenclonine	24-45	tryptophan hydroxylase 1	Rattus norvegicus	70-92
7274094-1	1981	Maternal treatment with p-chlorophenylalanine strongly inhibits brain tryptophan hydroxylase (TPH) activity in the embryo, whereas administration of tryptophan significantly elevates the activity of this enzyme.	Fenclonine	24-45	tryptophan hydroxylase 1	Rattus norvegicus	94-97
6257849-5	1981	Cerebral hyperglycinemia was also produced by chronic treatment with phenylalanine plus p-chlorophenylalanine to inhibit PAH, but not by acute (12 h) hyperphenylalaninemia.	Fenclonine	88-109	phenylalanine hydroxylase	Rattus norvegicus	121-124
6449965-0	1980	Effects of p-chlorophenylalanine on the rise in serum prolactin associated with nesting in broody turkeys.	Fenclonine	11-32	prolactin	Meleagris gallopavo	54-63
7430898-7	1980	The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.	Fenclonine	36-57	gonadotropin releasing hormone receptor	Rattus norvegicus	99-101
7430898-7	1980	The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.	Fenclonine	36-57	gonadotropin releasing hormone receptor	Rattus norvegicus	141-143
6457138-8	1981	The effects of p-chloroamphetamine on plasma renin activity and plasma corticosterone were prevented by prior administration of p-chlorophenylalanine.	Fenclonine	128-149	renin	Rattus norvegicus	45-50
155993-6	1979	Moreover, the enhanced reflex bradycardia induced by PCPA treatment was readily blocked by the replacement of the depleted brain 5-HT with 5-HTP and Ro 4-4602.	Fenclonine	53-57	POU class 6 homeobox 1	Rattus norvegicus	123-130
155057-0	1979	The mechanism of the irreversible inhibition ofrat liver phenylalanine hydroxylase due to treatment with p-chlorophenylalanine.	Fenclonine	105-126	phenylalanine hydroxylase	Rattus norvegicus	57-82
155057-2	1979	The administration of a single dose of p-chlorophenylalanine (360 mg/kg) to rats leads to the irreversible loss of 90% of hepatic phenylalanine hydroxylase activity after 24 h. This loss of activity is not the result of either an alteration in the overall structure of the enzyme, as determined by its antigenicity, or in the total immunologically reactive protein in the liver, as tested with a specific antiserum prepared against native phenylalanine hydroxylase.	Fenclonine	39-60	phenylalanine hydroxylase	Rattus norvegicus	130-155
155057-2	1979	The administration of a single dose of p-chlorophenylalanine (360 mg/kg) to rats leads to the irreversible loss of 90% of hepatic phenylalanine hydroxylase activity after 24 h. This loss of activity is not the result of either an alteration in the overall structure of the enzyme, as determined by its antigenicity, or in the total immunologically reactive protein in the liver, as tested with a specific antiserum prepared against native phenylalanine hydroxylase.	Fenclonine	39-60	phenylalanine hydroxylase	Rattus norvegicus	439-464
313251-2	1979	As parachlorophenylalanine appears to reduce release of prolactin (PRL) and melanocyte-stimulating hormone (MSH) in the eel, a stimulating serotoninergic control of these adenohypophysial secretions was suspected.	Fenclonine	3-26	prolactin	Homo sapiens	56-65
313251-2	1979	As parachlorophenylalanine appears to reduce release of prolactin (PRL) and melanocyte-stimulating hormone (MSH) in the eel, a stimulating serotoninergic control of these adenohypophysial secretions was suspected.	Fenclonine	3-26	prolactin	Homo sapiens	67-70
313251-2	1979	As parachlorophenylalanine appears to reduce release of prolactin (PRL) and melanocyte-stimulating hormone (MSH) in the eel, a stimulating serotoninergic control of these adenohypophysial secretions was suspected.	Fenclonine	3-26	proopiomelanocortin	Homo sapiens	76-106
313251-2	1979	As parachlorophenylalanine appears to reduce release of prolactin (PRL) and melanocyte-stimulating hormone (MSH) in the eel, a stimulating serotoninergic control of these adenohypophysial secretions was suspected.	Fenclonine	3-26	proopiomelanocortin	Homo sapiens	108-111
153543-2	1978	Treatment with both p-chlorophenylalanine (p-CPA) at 200 mg/kg and lesions of the medial raphe nucleus impaired the acquisition of a step-off passive-avoidance response.	Fenclonine	20-41	carboxypeptidase A1	Homo sapiens	45-48
150951-0	1978	Effect of parachlorophenylalanine, a brain serotonin depletor, on the prolactin cells of the eel pituitary.	Fenclonine	10-33	prolactin	Homo sapiens	70-79
150951-6	1978	Brain serotonin depletion probably decreases granule release in PRL cells, a result comparable to the lowering action of pCPA on the plasma PRL level in some mammals.	Fenclonine	121-125	prolactin	Homo sapiens	140-143
149011-5	1978	or p-chlorophenylalanine (100 mg/kg X 3, orally) pretreatment markedly blocked the prolactin-releasing effect of both d-fenfluramine and quipazine.	Fenclonine	3-24	prolactin	Rattus norvegicus	83-92
160866-1	1979	The results of our recent investigations have suggested that tolerance and cross-tolerance development to motor-impairing and hypothermic effects of ethanol was slowed when brain serotonin (5-HT) was extensively depleted by treatment with p-chlorophenylalanine (p-CPA).	Fenclonine	239-260	carboxypeptidase A1	Homo sapiens	264-267
153746-0	1978	Isoenzyme composition of hepatic phenylalanine hydroxylase in developing rats after treatment with cortisol, alpha-methylphenylalanine and p-chlorophenylalanine in vivo.	Fenclonine	139-160	phenylalanine hydroxylase	Rattus norvegicus	33-58
200440-7	1977	p-Chlorophenylalanine (PCPA) completely blocked the antagonistic effect of TRH on all PB-induced hormonal changes, suggesting that serotoninergic mechanisms may be involved in the extra-pituitary effect of TRH.	Fenclonine	0-21	thyrotropin releasing hormone	Rattus norvegicus	75-78
148665-3	1978	Parachlorophenylalanine (PCPA), an inhibitor of serotonin synthesis, significantly potentiated the increase in PRL produced by N,N-DMT, and psilocybin.	Fenclonine	0-23	prolactin	Rattus norvegicus	111-114
148665-3	1978	Parachlorophenylalanine (PCPA), an inhibitor of serotonin synthesis, significantly potentiated the increase in PRL produced by N,N-DMT, and psilocybin.	Fenclonine	25-29	prolactin	Rattus norvegicus	111-114
200440-7	1977	p-Chlorophenylalanine (PCPA) completely blocked the antagonistic effect of TRH on all PB-induced hormonal changes, suggesting that serotoninergic mechanisms may be involved in the extra-pituitary effect of TRH.	Fenclonine	0-21	thyrotropin releasing hormone	Rattus norvegicus	206-209
200440-7	1977	p-Chlorophenylalanine (PCPA) completely blocked the antagonistic effect of TRH on all PB-induced hormonal changes, suggesting that serotoninergic mechanisms may be involved in the extra-pituitary effect of TRH.	Fenclonine	23-27	thyrotropin releasing hormone	Rattus norvegicus	75-78
200440-7	1977	p-Chlorophenylalanine (PCPA) completely blocked the antagonistic effect of TRH on all PB-induced hormonal changes, suggesting that serotoninergic mechanisms may be involved in the extra-pituitary effect of TRH.	Fenclonine	23-27	thyrotropin releasing hormone	Rattus norvegicus	206-209
180005-0	1976	Mechanism of inactivation of phenylalanine hydroxylase by p-chlorophenylalanine in hepatome cells in culture.	Fenclonine	58-79	phenylalanine hydroxylase	Rattus norvegicus	29-54
22619-1	1977	p-Chlorophenylalanine, which produces a depletion of brain 5-HT concentration, had effects qualitatively similar to those previously found with chronic chlordiazepoxide and with acute ethanol in the social interaction test of anxiety.	Fenclonine	0-21	POU class 6 homeobox 1	Homo sapiens	53-60
145879-3	1977	Combination of p.chlorophenylalanine, strongly inhibitor of phenylalanine hydroxylase, and cotrimoxazole, presumably inhibitor of dihydropteridine reductase, produced a good inhibition of phenylalanine hydroxylation in vivo.	Fenclonine	15-36	phenylalanine hydroxylase	Rattus norvegicus	60-85
180005-2	1976	The mechanism by which p-chlorophenylalanine specifically reduces phenylalanine hydroxylase activity in rat liver in vivo and in Reuber H4 hepatoma cells in culture has been investigated.	Fenclonine	23-44	phenylalanine hydroxylase	Rattus norvegicus	66-91
180005-3	1976	Chromatography on hydroxylapatite of liver extract from rats injected with p-chlorophenylalanine showed that the compound differentially affected the three normal phenylalanine hydroxylase isoenzymes (I, II, and III); isoenzymes II and III were completely absent after the treatment, but isoenzyme I was only reduced in quantity compared with normal adult rats.	Fenclonine	75-96	phenylalanine hydroxylase	Rattus norvegicus	163-188
180005-5	1976	There is evidence, based on immunochemical techniques, that cultures grown in the presence of p-chlorophenylalanine have significantly reduced levels of phenylalanine hydroxylase antigen, and that p-chlorophenylalanine inactivates phenylalanine hydroxylase at or near the time of enzyme synthesis.	Fenclonine	94-115	phenylalanine hydroxylase	Rattus norvegicus	153-178
180005-5	1976	There is evidence, based on immunochemical techniques, that cultures grown in the presence of p-chlorophenylalanine have significantly reduced levels of phenylalanine hydroxylase antigen, and that p-chlorophenylalanine inactivates phenylalanine hydroxylase at or near the time of enzyme synthesis.	Fenclonine	94-115	phenylalanine hydroxylase	Rattus norvegicus	231-256
180005-8	1976	In addition, p-chlorophenylacetate was found to inactivate phenylalanine hydroxylase in an apparently identical manner with p-chlorophenylalanine, which almost certainly eliminates from consideration any mechanism of inactivation specifically requiring an amino acid.	Fenclonine	124-145	phenylalanine hydroxylase	Rattus norvegicus	59-84
180005-11	1976	The model most consistent with all data requires (predicts) the existence of a proenzyme form of phenylalanine hydroxylase which can be specifically inactivated by p-chlorophenylalanine.	Fenclonine	164-185	phenylalanine hydroxylase	Rattus norvegicus	97-122
11370231-5	1976	Responses of the vas deferens to transmural stimulation are depressed by pretreatment of rats with p-chlorophenylalanine, and the depression is reversed by incubation in vitro with 5-hydroxytryptophan or serotonin.	Fenclonine	99-120	arginine vasopressin	Rattus norvegicus	17-20
133670-2	1976	Maximum inhibition of phenylalanine hydroxylase activity in the liver (85%) and in the kidney (50%) of suckling rats required the administration of over 9 mumol of p-chlorophenylalanine/10g body weight.	Fenclonine	164-185	phenylalanine hydroxylase	Rattus norvegicus	22-47
133671-2	1976	Injections of phenylalanine increased a 2.5-fold in 9 h the hepatic phenylalanine hydroxylase activity of 6-day-old or adult rats that had been pretreated (24h earlier) with p-chlorophenylalanine; without such pretreatment, phenylalanine did not raise the enzyme concentration.	Fenclonine	174-195	phenylalanine hydroxylase	Rattus norvegicus	68-93
133671-4	1976	The hormonal induction of hepatic phenylalanine hydroxylase activity obeyed different rules: an injection of cortisol was without effect on adult livers but caused a threefold rise in phenylalanine hydroxylase activity of immature ones, both without and after pretreatment with p-chlorophenylalanine.	Fenclonine	278-299	phenylalanine hydroxylase	Rattus norvegicus	34-59
133671-8	1976	The negative effector, p-chlorophenylalanine, also appears to interact with the synthetic (or degradative) machinery rather than with the existing phenylalanine hydroxylase molecules: 24h were required in vivo for an 85% decrease to ensue, and no inhibition occurred in vitro when incubating the enzyme with p-chlorophenylalanine or with liver extracts from p-chlorophenylalanine-treated rats.	Fenclonine	23-44	phenylalanine hydroxylase	Rattus norvegicus	147-172
1275619-10	1976	The inhibitor of catechol-O-methyltransferase, tropolone, reduced the density of bially blocks the uptake of NA, was more potent on PGO(PCPA) than on PGO(1284).	Fenclonine	136-140	catechol-O-methyltransferase	Felis catus	17-45
130636-1	1976	Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats.	Fenclonine	27-50	prolactin	Rattus norvegicus	189-198
130636-1	1976	Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats.	Fenclonine	27-50	prolactin	Rattus norvegicus	200-203
130636-1	1976	Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats.	Fenclonine	52-56	prolactin	Rattus norvegicus	189-198
130636-1	1976	Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats.	Fenclonine	52-56	prolactin	Rattus norvegicus	200-203
136660-0	1976	What is the mechanism of the irreversible inhibition of phenylalanine hydroxylase by p-chlorophenylalanine?	Fenclonine	85-106	phenylalanine hydroxylase	Homo sapiens	56-81
125543-8	1975	Parachlorophenylalanine (PCPA) an inhibitor of serotonin synthesis caused a paradoxical rise in GH levels.	Fenclonine	0-23	growth hormone 1	Homo sapiens	96-98
124733-5	1975	p-Chlorophenylalanine, which irreversibly inhibits phenylalanine hydroxylase in vivo, caused a similar degree of inhibition of the rate of deuteron formation as was found when phenylalanine hydroxylase was measured in extracts from the same group of animals.	Fenclonine	0-21	phenylalanine hydroxylase	Rattus norvegicus	51-76
124733-5	1975	p-Chlorophenylalanine, which irreversibly inhibits phenylalanine hydroxylase in vivo, caused a similar degree of inhibition of the rate of deuteron formation as was found when phenylalanine hydroxylase was measured in extracts from the same group of animals.	Fenclonine	0-21	phenylalanine hydroxylase	Rattus norvegicus	176-201
125543-8	1975	Parachlorophenylalanine (PCPA) an inhibitor of serotonin synthesis caused a paradoxical rise in GH levels.	Fenclonine	25-29	growth hormone 1	Homo sapiens	96-98
234440-0	1975	p-Chlorphenylalanine effect on phenylalanine hydroxylase in hepatoma cells in culture.	Fenclonine	0-20	phenylalanine hydroxylase	Homo sapiens	31-56
234440-2	1975	The similarity of the effect of p-chlorophenylalanine on phenylalanine hydroxylase in the hepatoma cells and that reported from studies in vivo indicates that the loss of phenylalanine hydroxylase activity is due to a direct interaction of the amino acid analogue with the liver.	Fenclonine	32-53	phenylalanine hydroxylase	Homo sapiens	57-82
234440-2	1975	The similarity of the effect of p-chlorophenylalanine on phenylalanine hydroxylase in the hepatoma cells and that reported from studies in vivo indicates that the loss of phenylalanine hydroxylase activity is due to a direct interaction of the amino acid analogue with the liver.	Fenclonine	32-53	phenylalanine hydroxylase	Homo sapiens	171-196
4269184-2	1973	Phenethylamines were extracted from brain and liver of rats with phenylketonuria-like characteristics produced in vivo by inhibition of phenylalanine hydroxylase (EC 1.14.3.1) with p-chlorophenylalanine, with or without phenylalanine administration.	Fenclonine	181-202	phenylalanine hydroxylase	Rattus norvegicus	136-161
124571-0	1975	In vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine and Esculin.	Fenclonine	61-82	phenylalanine hydroxylase	Rattus norvegicus	32-57
4280309-0	1974	Inhibition of phenylalanine hydroxylase by p-chlorophenylalanine; dependence on cofactor structure.	Fenclonine	43-64	phenylalanine hydroxylase	Homo sapiens	14-39
4260277-2	1972	This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood.	Fenclonine	81-102	phenylalanine hydroxylase	Rattus norvegicus	38-63
5440301-0	1970	The effects of 5-HTP on para-Chlorophenylalanine (p-CPA) attenuation of "conflict" behavior.	Fenclonine	24-48	carboxypeptidase A1	Homo sapiens	52-55
4313993-0	1970	Effects of alpha methyl tyrosine and p-chlorophenylalanine on the regulation of ACTH secretion.	Fenclonine	37-58	proopiomelanocortin	Homo sapiens	80-84
6067026-1	1967	p-Chlorophenylalanine, a potent inhibitor of phenylalanine hydroxylase in vivo, has been used to simulate phenylketonuria in rats.	Fenclonine	0-21	phenylalanine hydroxylase	Rattus norvegicus	45-70
5354778-0	1969	Irreversible in vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine.	Fenclonine	74-95	phenylalanine hydroxylase	Rattus norvegicus	45-70
32855692-7	2020	The relative expression of hippocampal IL-6, TNF-alpha, NF-kappaB and mGluR2 mRNA of the PCPA+D-gal-induced ageing insomnia group was higher, while the relative expression of 5-HT1AR and GABAARa1 mRNA were lower.	Fenclonine	89-93	interleukin 6	Rattus norvegicus	39-43
153135-1	1978	The phenylalanine analogues p-chlorophenylalanine and alpha-methylphenylalanine were used to inhibit phenylalanine hydroxylase in animal models for phenylketonuria.	Fenclonine	28-49	phenylalanine hydroxylase	Mus musculus	101-126
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	tryptophan hydroxylase 1	Rattus norvegicus	42-46
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	tryptophan hydroxylase 2	Rattus norvegicus	51-55
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	5-hydroxytryptamine receptor 2C	Rattus norvegicus	80-85
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	156-159
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	arginine vasopressin	Rattus norvegicus	161-164
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	corticotropin releasing hormone	Rattus norvegicus	166-169
33083963-9	2021	At the gene expression level, the mRNA of Tph1 and Tph2 were lower in DRN while Htr2c was higher in the amygdala of pCPA-treated males, while Htr1a, Htr2c, Oxt, Avp, Crh, and Trh were not different in any treatments or sex in PVN.	Fenclonine	116-120	thyrotropin releasing hormone	Rattus norvegicus	175-178
33262643-12	2020	Intra-RVM microinjection of Tph inhibitor PCPA significantly attenuated mechanical and thermal pain behavior through Tph downregulation and decreased spinal 5-HT.	Fenclonine	42-46	tryptophan hydroxylase 1	Rattus norvegicus	28-31
33262643-12	2020	Intra-RVM microinjection of Tph inhibitor PCPA significantly attenuated mechanical and thermal pain behavior through Tph downregulation and decreased spinal 5-HT.	Fenclonine	42-46	tryptophan hydroxylase 1	Rattus norvegicus	117-120
32855692-7	2020	The relative expression of hippocampal IL-6, TNF-alpha, NF-kappaB and mGluR2 mRNA of the PCPA+D-gal-induced ageing insomnia group was higher, while the relative expression of 5-HT1AR and GABAARa1 mRNA were lower.	Fenclonine	89-93	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	70-76
32855692-8	2020	The serum levels of IL-1beta, IL-6, TNF-alpha and brain level of glutamate increased in the PCPA+D-gal-induced ageing insomnia group, while the levels of 5-HT and GABA decreased.	Fenclonine	92-96	interleukin 1 alpha	Rattus norvegicus	20-28
32855692-8	2020	The serum levels of IL-1beta, IL-6, TNF-alpha and brain level of glutamate increased in the PCPA+D-gal-induced ageing insomnia group, while the levels of 5-HT and GABA decreased.	Fenclonine	92-96	interleukin 6	Rattus norvegicus	30-34
32855692-8	2020	The serum levels of IL-1beta, IL-6, TNF-alpha and brain level of glutamate increased in the PCPA+D-gal-induced ageing insomnia group, while the levels of 5-HT and GABA decreased.	Fenclonine	92-96	tumor necrosis factor	Rattus norvegicus	36-45
32359608-13	2020	In addition, increased GnRH-I, LHss, and FSHss and decreased VIP mRNA expression was observed in the PCPA group compared with the controls.	Fenclonine	101-105	gonadotropin releasing hormone 1	Gallus gallus	23-29
32359608-13	2020	In addition, increased GnRH-I, LHss, and FSHss and decreased VIP mRNA expression was observed in the PCPA group compared with the controls.	Fenclonine	101-105	vasoactive intestinal peptide	Gallus gallus	61-64
28855642-7	2017	Furthermore, the Tph1-/- +5-HTP group showed more severe adhesions than did the Tph1-/- group mice, and the p-chlorophenylalanine (PCPA) could markedly alleviated the adhesion formation in the WT mice.	Fenclonine	131-135	tryptophan hydroxylase 1	Mus musculus	17-21
32392202-14	2020	Thus, a new method was proposed to study the STEP activity in the brain and p-chlorophenylalanine and pargyline were shown to decrease Ptpn5 expression in the striatum in mice.	Fenclonine	76-97	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	135-140
30142397-7	2019	Similar to PCPA, the treatment with the NOP agonists Ro 65-6570 and AT-090 also increased aggressive behaviors.	Fenclonine	11-15	crystallin, gamma B	Mus musculus	40-43
30071571-7	2019	The data also shows that anti-immobility effect of BF (10 mg/kg) in the TST was reversed by prazosin, yohimbine, haloperidol, sulpiride, metagoline and PCPA but not with propranolol.	Fenclonine	152-156	thiosulfate sulfurtransferase	Homo sapiens	72-75
30783717-8	2019	The antidepressant-like effects of the new compounds in the FST were prevented by pretreatment of mice with pCPA (serotonin depletor), (-)pindolol (mixed 5-HT1A/1B and beta-adrenergic antagonist), and WAY 100635 (selective 5-HT1A antagonist).	Fenclonine	108-112	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	223-229
30030171-7	2019	The colitis-induced loss of trabecular bone was significantly suppressed in mice treated with the 5-HT synthesis inhibitor, p-chloro-DL-phenylalanine (PCPA; 300 mg/kg/day IP daily), and in mice treated with the 5-HT1B receptor antagonist GR55562 (1 mg/Kg/day SC daily).	Fenclonine	151-155	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	211-226
29340081-1	2017	The purpose of this study was to investigate the mechanism of monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and determine whether 4-chloro-DL-phenylalanine (PCPA) could inhibit pulmonary arterial remodeling associated with connective tissue growth factor (CTGF) expression and downstream signal pathway.	Fenclonine	148-173	cellular communication network factor 2	Rattus norvegicus	241-272
29340081-1	2017	The purpose of this study was to investigate the mechanism of monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and determine whether 4-chloro-DL-phenylalanine (PCPA) could inhibit pulmonary arterial remodeling associated with connective tissue growth factor (CTGF) expression and downstream signal pathway.	Fenclonine	175-179	cellular communication network factor 2	Rattus norvegicus	241-272
29340081-1	2017	The purpose of this study was to investigate the mechanism of monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and determine whether 4-chloro-DL-phenylalanine (PCPA) could inhibit pulmonary arterial remodeling associated with connective tissue growth factor (CTGF) expression and downstream signal pathway.	Fenclonine	175-179	cellular communication network factor 2	Rattus norvegicus	274-278
29340081-8	2017	PCPA significantly ameliorated pulmonary arterial remodeling induced by MCT, and this action was associated with accelerated apoptosis and down-regulation of CTGF, SR-1B and p-ERK/ERK.	Fenclonine	0-4	cellular communication network factor 2	Rattus norvegicus	158-162
29340081-8	2017	PCPA significantly ameliorated pulmonary arterial remodeling induced by MCT, and this action was associated with accelerated apoptosis and down-regulation of CTGF, SR-1B and p-ERK/ERK.	Fenclonine	0-4	5-hydroxytryptamine receptor 1B	Rattus norvegicus	164-169
29340081-8	2017	PCPA significantly ameliorated pulmonary arterial remodeling induced by MCT, and this action was associated with accelerated apoptosis and down-regulation of CTGF, SR-1B and p-ERK/ERK.	Fenclonine	0-4	Eph receptor B1	Rattus norvegicus	176-179
29340081-8	2017	PCPA significantly ameliorated pulmonary arterial remodeling induced by MCT, and this action was associated with accelerated apoptosis and down-regulation of CTGF, SR-1B and p-ERK/ERK.	Fenclonine	0-4	Eph receptor B1	Rattus norvegicus	180-183
29340081-9	2017	The present study suggests that PCPA protects against the pathogenesis of PAH by suppressing remodeling and inducing apoptosis, which are likely associated with CTGF and downstream ERK signaling pathway in rats.	Fenclonine	32-36	cellular communication network factor 2	Rattus norvegicus	161-165
29340081-9	2017	The present study suggests that PCPA protects against the pathogenesis of PAH by suppressing remodeling and inducing apoptosis, which are likely associated with CTGF and downstream ERK signaling pathway in rats.	Fenclonine	32-36	Eph receptor B1	Rattus norvegicus	181-184
28855642-7	2017	Furthermore, the Tph1-/- +5-HTP group showed more severe adhesions than did the Tph1-/- group mice, and the p-chlorophenylalanine (PCPA) could markedly alleviated the adhesion formation in the WT mice.	Fenclonine	131-135	tryptophan hydroxylase 1	Mus musculus	80-84
26747370-6	2016	The 5-HT synthesis inhibitor para-chlorophenylalanine (pCPA), but not the NE neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) prevented URB597-mediated antidepressant/anxiolytic-like response in the FST and NSFT, while DSP4 did not further affect URB597-mediated increase in raphe 5-HT neuron firing.	Fenclonine	29-53	dual specificity phosphatase 26	Homo sapiens	233-237
27639596-6	2016	B. fragilis YCH46 and B. thetaiotaomicron VPI-5482 transformed with a pheS*-harboring shuttle vector were clearly growth-inhibited in the presence of >5 mM p-Cl-Phe in liquid defined minimal media (DMM) and on DMM agar plates.	Fenclonine	159-167	phenylalanine--tRNA ligase subunit alpha	Bacteroides thetaiotaomicron VPI-5482	70-74
28560440-0	2017	The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-kappaB.	Fenclonine	26-30	nuclear factor of activated T-cells 1	Rattus norvegicus	136-142
28560440-4	2017	Therefore, we hypothesized that PCPA may attenuate monocrotaline (MCT)-induced PAH through the NFAT-1 and NF-kappaB signaling pathways.	Fenclonine	32-36	nuclear factor of activated T-cells 1	Rattus norvegicus	95-101
28560440-14	2017	The above-mentioned findings suggest that the inhibitory effects of PCPA on MCT-induced inflammation and arterial remodeling are related to the downregulation of the NFAT-1 and NF-kappaB signaling pathways in rats with PAH.	Fenclonine	68-72	nuclear factor of activated T-cells 1	Rattus norvegicus	166-172
27730334-8	2017	The expression of PheS* in B. subtilis strain 168 and B. cereus strain ATCC 14579 caused pronounced sensitivity of both hosts to p-chloro-phenylalanine, indicating that pheS * could be used as a counter-selectable marker (CSM) in these strains.	Fenclonine	129-151	phenylalanyl-tRNA synthetase (alpha subunit)	Bacillus subtilis subsp. subtilis str. 168	18-23
27916355-13	2016	PCPA-treated SERTKO and WT-SSRI animals demonstrated reversal of 5-HT-induced growth and Gap 43 expression.	Fenclonine	0-4	growth associated protein 43	Mus musculus	89-95
26829988-6	2016	The presence of PcpA was associated with increased IL-6 levels, suppressed production of TRAIL, and reduced infiltration of polymorphonuclear cells.	Fenclonine	16-20	interleukin 6	Mus musculus	51-55
26829988-6	2016	The presence of PcpA was associated with increased IL-6 levels, suppressed production of TRAIL, and reduced infiltration of polymorphonuclear cells.	Fenclonine	16-20	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	89-94
26051791-10	2015	Both PCPA administration and active immunization against chicken VIP significantly increased testis weight, semen volume, sperm concentration, ejaculation grade, plasma testosterone level, and GnRH-I, FSH and LH gene expression compared with controls (P <= 0.05).	Fenclonine	5-9	gonadotropin releasing hormone 1	Gallus gallus	193-199
26816599-5	2016	RESULTS: Dexamethasone-induced whole-body IR, liver and intraabdominal adipose IR were accompanied by upregulated expressions of tryptophan hydroxylase-1 and aromatic amino acid decarboxylase with increased 5-HT level in both tissues, which were attenuated significantly by pCPA, inhibiting tryptophan hydroxylase-1, or carbidopa, inhibiting aromatic amino acid decarboxylase.	Fenclonine	274-278	tryptophan hydroxylase 1	Rattus norvegicus	129-153
26154191-4	2015	Serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2 isoform.	Fenclonine	107-128	tryptophan hydroxylase 1	Mus musculus	72-94
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	Fenclonine	158-162	ATP binding cassette subfamily B member 4	Rattus norvegicus	235-239
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	Fenclonine	158-162	phosphoglycolate phosphatase	Rattus norvegicus	244-248
26154191-4	2015	Serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2 isoform.	Fenclonine	107-128	tryptophan hydroxylase 1	Mus musculus	96-99
26154191-4	2015	Serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2 isoform.	Fenclonine	130-134	tryptophan hydroxylase 1	Mus musculus	72-94
26154191-4	2015	Serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2 isoform.	Fenclonine	130-134	tryptophan hydroxylase 1	Mus musculus	96-99
25716782-5	2015	Supporting these differences to be important for the behavioral differences, serotonin depletion obtained by the tryptophan hydroxylase-2 inhibitor p-chlorophenylalanine eliminated them by reducing anxiety in "anxious" but not "non-anxious" rats.	Fenclonine	148-169	tryptophan hydroxylase 2	Rattus norvegicus	113-137
25917396-3	2015	Western blot analysis showed GPR39 up-regulation following 3-day administration of alphaMT and NMDA in the frontal cortex, and GPR39 down-regulation following 10-day administration of pCPA, alphaMT, and NMDA in the hippocampus of CD-1 mice.	Fenclonine	184-188	G protein-coupled receptor 39	Mus musculus	127-132
24757500-0	2014	Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.	Fenclonine	85-89	lysine demethylase 1A	Homo sapiens	41-45
25000567-1	2014	The Fourier transform infrared (4000-400cm(-1)) and Fourier transform Raman (3500-50cm(-1)) spectra of 4-Chloro-dl-phenylalanine (4CLPA) were recorded and analyzed.	Fenclonine	103-128	T-box transcription factor 22	Homo sapiens	131-135
25281790-1	2014	The role of the serotonergic system in regulating the expression of estrogen receptor (ER) alpha in the hypothalamus was investigated in ovariectomized rats by injecting a serotonin synthesis inhibitor, parachlorophenylalanine (PCPA), or by destroying the dorsal raphe nucleus (DR).	Fenclonine	228-232	estrogen receptor 1	Rattus norvegicus	68-96
24271033-6	2014	The systemic administration of the 5-HT(1A) agonist, 8-OH-DPAT, decreased the firing rate and increased the coefficient of variation of STN neurons in pCPA-treated rats but not in control animals.	Fenclonine	151-155	5-hydroxytryptamine receptor 1A	Rattus norvegicus	35-42
25447484-4	2015	The anti-immobility effect of PA01 in the TST was significantly prevented by the pretreatment of mice with DL-p-chlorophenylalanine (pCPA, 300mg/kg, an inhibitor of serotonin synthesis), SCH23390 (0.05mg/kg, s.c., dopamine D1 receptor antagonist), and sulpiride (50mg/kg, i.p., dopamine D2 receptor antagonist).	Fenclonine	107-131	dopamine receptor D2	Mus musculus	278-298
25447484-4	2015	The anti-immobility effect of PA01 in the TST was significantly prevented by the pretreatment of mice with DL-p-chlorophenylalanine (pCPA, 300mg/kg, an inhibitor of serotonin synthesis), SCH23390 (0.05mg/kg, s.c., dopamine D1 receptor antagonist), and sulpiride (50mg/kg, i.p., dopamine D2 receptor antagonist).	Fenclonine	133-137	dopamine receptor D2	Mus musculus	278-298
25035531-12	2014	Reversal of this potentiation with p-chlorophenylalanine suggests a pharmacodynamic interaction through involvement of presynaptic 5-HT1A receptors.	Fenclonine	35-56	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	131-137
24162946-4	2014	After PCPA treatment, POMC and CART did not decrease despite food deprivation.	Fenclonine	6-10	proopiomelanocortin	Rattus norvegicus	22-26
24162946-4	2014	After PCPA treatment, POMC and CART did not decrease despite food deprivation.	Fenclonine	6-10	CART prepropeptide	Rattus norvegicus	31-35
24162946-5	2014	NPY was significantly increased by food deprivation with PCPA, but was attenuated compared to food deprivation without PCPA.	Fenclonine	57-61	neuropeptide Y	Rattus norvegicus	0-3
24162946-5	2014	NPY was significantly increased by food deprivation with PCPA, but was attenuated compared to food deprivation without PCPA.	Fenclonine	119-123	neuropeptide Y	Rattus norvegicus	0-3
24337018-1	2014	The present study was performed to investigate the effects of 4-chloro-DL-phenylalanine (PCPA), a tryptophan hydroxylase (Tph) inhibitor (TphI), on pulmonary vascular remodeling and lung inflammation in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats.	Fenclonine	62-87	tryptophan hydroxylase 1	Rattus norvegicus	98-120
24337018-1	2014	The present study was performed to investigate the effects of 4-chloro-DL-phenylalanine (PCPA), a tryptophan hydroxylase (Tph) inhibitor (TphI), on pulmonary vascular remodeling and lung inflammation in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats.	Fenclonine	62-87	tryptophan hydroxylase 1	Rattus norvegicus	122-125
24337018-1	2014	The present study was performed to investigate the effects of 4-chloro-DL-phenylalanine (PCPA), a tryptophan hydroxylase (Tph) inhibitor (TphI), on pulmonary vascular remodeling and lung inflammation in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats.	Fenclonine	89-93	tryptophan hydroxylase 1	Rattus norvegicus	98-120
24337018-1	2014	The present study was performed to investigate the effects of 4-chloro-DL-phenylalanine (PCPA), a tryptophan hydroxylase (Tph) inhibitor (TphI), on pulmonary vascular remodeling and lung inflammation in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats.	Fenclonine	89-93	tryptophan hydroxylase 1	Rattus norvegicus	122-125
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	tryptophan hydroxylase 1	Rattus norvegicus	118-123
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	solute carrier family 6 member 4	Rattus norvegicus	128-132
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	matrix metallopeptidase 2	Rattus norvegicus	166-174
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	176-185
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	interleukin 1 beta	Rattus norvegicus	187-204
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	interleukin 1 beta	Rattus norvegicus	206-214
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	tumor necrosis factor	Rattus norvegicus	217-244
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	tumor necrosis factor	Rattus norvegicus	246-255
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	intercellular adhesion molecule 1	Rattus norvegicus	261-294
24337018-9	2014	PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1).	Fenclonine	0-4	intercellular adhesion molecule 1	Rattus norvegicus	296-302
24337018-10	2014	These findings suggest that the amelioration of MCT-induced pulmonary vascular remodeling and lung inflammation by PCPA is associated with the downregulation of Tph-1, SERT, MMP/TIMP and inflammatory cytokine expression in rats.	Fenclonine	115-119	tryptophan hydroxylase 1	Rattus norvegicus	161-166
24337018-10	2014	These findings suggest that the amelioration of MCT-induced pulmonary vascular remodeling and lung inflammation by PCPA is associated with the downregulation of Tph-1, SERT, MMP/TIMP and inflammatory cytokine expression in rats.	Fenclonine	115-119	solute carrier family 6 member 4	Rattus norvegicus	168-172
24337018-10	2014	These findings suggest that the amelioration of MCT-induced pulmonary vascular remodeling and lung inflammation by PCPA is associated with the downregulation of Tph-1, SERT, MMP/TIMP and inflammatory cytokine expression in rats.	Fenclonine	115-119	matrix metallopeptidase 2	Rattus norvegicus	174-177
24337018-10	2014	These findings suggest that the amelioration of MCT-induced pulmonary vascular remodeling and lung inflammation by PCPA is associated with the downregulation of Tph-1, SERT, MMP/TIMP and inflammatory cytokine expression in rats.	Fenclonine	115-119	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	178-182
23916504-8	2014	Vortioxetine reversed PCPA-induced memory deficits dose-dependently with a minimal effective dose (MED) <=0.1mg/kg (~80% 5-HT3 receptor occupancy; OR) and <=3.0mg/kg (5-HT1A, 5-HT1B, 5-HT3 receptor occupancy: ~15%, 60%, 95%) in SA.	Fenclonine	22-26	5-hydroxytryptamine receptor 1A	Rattus norvegicus	173-179
23916504-8	2014	Vortioxetine reversed PCPA-induced memory deficits dose-dependently with a minimal effective dose (MED) <=0.1mg/kg (~80% 5-HT3 receptor occupancy; OR) and <=3.0mg/kg (5-HT1A, 5-HT1B, 5-HT3 receptor occupancy: ~15%, 60%, 95%) in SA.	Fenclonine	22-26	5-hydroxytryptamine receptor 1B	Rattus norvegicus	181-187
23916504-8	2014	Vortioxetine reversed PCPA-induced memory deficits dose-dependently with a minimal effective dose (MED) <=0.1mg/kg (~80% 5-HT3 receptor occupancy; OR) and <=3.0mg/kg (5-HT1A, 5-HT1B, 5-HT3 receptor occupancy: ~15%, 60%, 95%) in SA.	Fenclonine	22-26	5-hydroxytryptamine receptor 3A	Rattus norvegicus	189-203
24492464-3	2014	The 5-HT synthesis inhibitor, p-chlorophenylalanine, attenuated the daily rhythm of Per1 and Per2 gene expression in the intestine.	Fenclonine	30-51	period circadian clock 2	Mus musculus	93-97
23871843-8	2013	Conversely, pCPA-treated MAO-A KO mice did not exhibit significant changes in anxiety-like behaviors in a novel open-field and elevated plus-maze; furthermore, this regimen did not modify their social deficits, aggressive behaviors and impairments in tactile sensitivity.	Fenclonine	12-16	monoamine oxidase A	Mus musculus	25-30
23841816-7	2013	Furthermore, a 1-week administration of the 5-HT1A receptor agonist 8-OH-DPAT in Pet1(-/-) and PCPA-treated mice normalised hippocampal cell survival.	Fenclonine	95-99	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	44-59
24029579-0	2013	[Expression of cation-chloride cotransporters KCC2 and NKCC1 in brainstem of para- chlorophenylalanine-induced acute insomnia rats].	Fenclonine	77-102	solute carrier family 12 member 5	Rattus norvegicus	46-50
23360216-10	2013	PCPA also prevented the effect of fluoxetine on ERK1/2 phosphorylation without affecting p38 MAPK phosphorylation.	Fenclonine	0-4	mitogen activated protein kinase 3	Rattus norvegicus	48-54
24029579-0	2013	[Expression of cation-chloride cotransporters KCC2 and NKCC1 in brainstem of para- chlorophenylalanine-induced acute insomnia rats].	Fenclonine	77-102	solute carrier family 12 member 2	Rattus norvegicus	55-60
23325814-8	2013	Parachlorophenylalanine treatment increased reproductive performance and mRNA expression of GnRH-I, LH-beta and FSH-beta (P < 0.05) in the Green group to levels which did not differ from those of the White (control) group.	Fenclonine	0-23	gonadotropin releasing hormone 1	Gallus gallus	92-98
23325814-8	2013	Parachlorophenylalanine treatment increased reproductive performance and mRNA expression of GnRH-I, LH-beta and FSH-beta (P < 0.05) in the Green group to levels which did not differ from those of the White (control) group.	Fenclonine	0-23	follicle stimulating hormone beta subunit	Gallus gallus	112-120
21846421-5	2012	The 5-HT synthesis inhibitor p-chlorophenylalanine (250 mg/kg twice daily for 3 d) abolished the difference in 5-HT4 binding between 5-HTT-/- and 5-HTT+/+ mice in all brain regions.	Fenclonine	29-50	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	133-138
22996046-4	2013	The antidepressant-like effect of hesperidin (0.3 mg/kg) on the TST was prevented by the pretreatment of mice with p-chlorophenylalanine methyl ester (pCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis) and WAY100635 (0.1 mg/kg, subcutaneous, s.c., a selective 5-HT(1A) receptor antagonist).	Fenclonine	151-155	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	269-286
21846421-5	2012	The 5-HT synthesis inhibitor p-chlorophenylalanine (250 mg/kg twice daily for 3 d) abolished the difference in 5-HT4 binding between 5-HTT-/- and 5-HTT+/+ mice in all brain regions.	Fenclonine	29-50	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	146-151
21876464-0	2011	P-chlorophenylalanine increases glutamate receptor 1 transcription in rat amygdala.	Fenclonine	0-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-52
22561036-6	2012	And vice versa, administration of TPH2 inhibitor p-chlorophenylalanine (pCPA) (300 mg/kg, i.p., for 3 consecutive days) to B6 mice dramatically reduced the 5-HT and 5-HIAA contents in brain structures and attenuated the frequency and the duration of aggressive attacks.	Fenclonine	49-70	tryptophan hydroxylase 2	Mus musculus	34-38
22561036-6	2012	And vice versa, administration of TPH2 inhibitor p-chlorophenylalanine (pCPA) (300 mg/kg, i.p., for 3 consecutive days) to B6 mice dramatically reduced the 5-HT and 5-HIAA contents in brain structures and attenuated the frequency and the duration of aggressive attacks.	Fenclonine	72-76	tryptophan hydroxylase 2	Mus musculus	34-38
21876464-5	2011	Using quantitative reverse transcriptase-polymerase chain reaction, we found that rats treated with P-chlorophenylalanine, an inhibitor of tyrosine-5-hydroxylase, resulted in a 21-fold increase in glutamate receptor 1 (GluR1) mRNA expression in the amygdala.	Fenclonine	100-121	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	197-217
21876464-5	2011	Using quantitative reverse transcriptase-polymerase chain reaction, we found that rats treated with P-chlorophenylalanine, an inhibitor of tyrosine-5-hydroxylase, resulted in a 21-fold increase in glutamate receptor 1 (GluR1) mRNA expression in the amygdala.	Fenclonine	100-121	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	219-224
21872219-7	2011	In addition, DL-p-chlorophenylalanine (PCPA)-induced depletion of serotonin (5-HT) and intraperitoneal and intrathecal injection of the 5-HT(1A) receptor antagonist WAY-100635 blocked the effect of taltirelin on allodynia.	Fenclonine	13-37	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	136-153
21872219-7	2011	In addition, DL-p-chlorophenylalanine (PCPA)-induced depletion of serotonin (5-HT) and intraperitoneal and intrathecal injection of the 5-HT(1A) receptor antagonist WAY-100635 blocked the effect of taltirelin on allodynia.	Fenclonine	39-43	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	136-153
20184120-2	2010	The neurons producing GnRH were detected immunocytochemically on days 18 and 21 of embryonic development and on day 15 of postnatal development of rats with normal serotonin metabolism and rats in which the synthesis of serotonin was inhibited by p-chlorophenylalanine.	Fenclonine	247-268	gonadotropin releasing hormone 1	Rattus norvegicus	22-26
20128812-5	2010	In SERT -/- mice, inhibition of 5-HT synthesis with p-chlorophenylalanine (PCPA) markedly depleted tissue 5-HT in all five brain areas examined and abolished WAY 100635 induced head twitches.	Fenclonine	52-73	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	3-7
20128812-5	2010	In SERT -/- mice, inhibition of 5-HT synthesis with p-chlorophenylalanine (PCPA) markedly depleted tissue 5-HT in all five brain areas examined and abolished WAY 100635 induced head twitches.	Fenclonine	75-79	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	3-7
19735478-9	2010	The 5-HT synthesis inhibitor PCPA decreased the anti-CD3 antibody-induced muscle hypercontractility in recovery phase.	Fenclonine	29-33	CD3 antigen, epsilon polypeptide	Mus musculus	53-56
21156177-10	2011	Changes in tph2 mRNA expression, 5-HTP, and 5-HT levels in the POA-HYP+OCT region of brains of methyltestosterone and para-chlorophenylalanine treated fishes during development further endorse our results.	Fenclonine	118-142	tryptophan 5-hydroxylase 2	Cricetulus griseus	11-15
20713044-7	2010	We also found that EE leads to a reduced intracortical GABAergic inhibition and an increased BDNF expression and that the modulation of these molecular factors is neutralized by cortical infusion of the 5-HT synthesis inhibitor pCPA.	Fenclonine	228-232	brain-derived neurotrophic factor	Rattus norvegicus	93-97
20010549-5	2010	Blocking TPH function by para-chlorophenylalanine (PCPA) reduced ANSC proliferation, which was rescued by exogenous 5-HT.	Fenclonine	25-49	tryptophan hydroxylase 1	Mus musculus	9-12
20010549-5	2010	Blocking TPH function by para-chlorophenylalanine (PCPA) reduced ANSC proliferation, which was rescued by exogenous 5-HT.	Fenclonine	51-55	tryptophan hydroxylase 1	Mus musculus	9-12
19410636-4	2009	Whole mount in situ hybridization showed that sox1a and huc expressions were downregulated in PCPA-treated embryos, which indicated a decrease in the number of nerve cells.	Fenclonine	94-98	SRY-box transcription factor 1a	Danio rerio	46-51
19410636-6	2009	Moreover, lysine-specific demethylase 1 morpholino injection (LSD1 MO) also induced increased cellular apoptosis in embryos just as PCPA.	Fenclonine	132-136	lysine (K)-specific demethylase 1a	Danio rerio	10-39
19410636-6	2009	Moreover, lysine-specific demethylase 1 morpholino injection (LSD1 MO) also induced increased cellular apoptosis in embryos just as PCPA.	Fenclonine	132-136	lysine (K)-specific demethylase 1a	Danio rerio	62-66
19410636-8	2009	These findings demonstrate for the first time that PCPA-induced apoptosis through inhibition of LSD1 demethylase activity and p53-dependent signaling pathway might be required for the maintenance of nerve cell apoptosis.	Fenclonine	51-55	lysine (K)-specific demethylase 1a	Danio rerio	96-100
19410636-8	2009	These findings demonstrate for the first time that PCPA-induced apoptosis through inhibition of LSD1 demethylase activity and p53-dependent signaling pathway might be required for the maintenance of nerve cell apoptosis.	Fenclonine	51-55	tumor protein p53	Danio rerio	126-129
19429033-3	2009	Combined depletion of both serotonin and norepinephrine with para-chlorophenylalanine (PCPA) resulted in a significant decrease in Smo and Ptc mRNA within the dentate gyrus subfield of the hippocampus.	Fenclonine	61-85	smoothened, frizzled class receptor	Rattus norvegicus	131-134
19497357-6	2009	The antinociception caused by the dichloromethane fraction was significantly attenuated by pre-treatment of mice with p-chlorophenylalanine methyl ester (PCPA, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days) and WAY-100635 (a 5-HT(1A) receptor antagonist, 0.3 mg/kg).	Fenclonine	154-158	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	260-277
19145225-10	2009	Pretreatment with para-chlorophenylalanine, a 5-HT synthesis inhibitor, restored head twitches in 5-HTT(-/-) mice to levels in 5-HTT(+/+) mice.	Fenclonine	18-42	huntingtin	Mus musculus	100-103
19145225-10	2009	Pretreatment with para-chlorophenylalanine, a 5-HT synthesis inhibitor, restored head twitches in 5-HTT(-/-) mice to levels in 5-HTT(+/+) mice.	Fenclonine	18-42	huntingtin	Mus musculus	129-132
19429033-3	2009	Combined depletion of both serotonin and norepinephrine with para-chlorophenylalanine (PCPA) resulted in a significant decrease in Smo and Ptc mRNA within the dentate gyrus subfield of the hippocampus.	Fenclonine	87-91	smoothened, frizzled class receptor	Rattus norvegicus	131-134
18420614-4	2008	Furthermore, inhibiting 5-HT synthesis with p-chlorophenylalanine or blocking the 5-HT receptor with methysergide (METH) increased milk protein gene expression.	Fenclonine	44-65	casein beta	Bos taurus	131-143
18784307-8	2008	Indeed, prolonged pretreatment of En1(cre/+); Otx2(flox/flox) mice with the 5-HT synthesis inhibitor para-chlorophenylalanine (pCPA) restored brain 5-HT content to control levels, fully reestablishing KA seizure susceptibility.	Fenclonine	101-125	engrailed 1	Mus musculus	34-37
18784307-8	2008	Indeed, prolonged pretreatment of En1(cre/+); Otx2(flox/flox) mice with the 5-HT synthesis inhibitor para-chlorophenylalanine (pCPA) restored brain 5-HT content to control levels, fully reestablishing KA seizure susceptibility.	Fenclonine	101-125	orthodenticle homeobox 2	Mus musculus	46-50
18784307-8	2008	Indeed, prolonged pretreatment of En1(cre/+); Otx2(flox/flox) mice with the 5-HT synthesis inhibitor para-chlorophenylalanine (pCPA) restored brain 5-HT content to control levels, fully reestablishing KA seizure susceptibility.	Fenclonine	127-131	engrailed 1	Mus musculus	34-37
18784307-8	2008	Indeed, prolonged pretreatment of En1(cre/+); Otx2(flox/flox) mice with the 5-HT synthesis inhibitor para-chlorophenylalanine (pCPA) restored brain 5-HT content to control levels, fully reestablishing KA seizure susceptibility.	Fenclonine	127-131	orthodenticle homeobox 2	Mus musculus	46-50
17692431-4	2008	We defined that the most potent peptide on Bcl-x(L), which presents a 4.6-fold increase as compared to the parent peptide affinity, was obtained when Ile85 was mutated with a 4-chlorophenylalanine.	Fenclonine	175-196	BCL2 like 1	Homo sapiens	43-51
19077321-11	2008	The number of Fos-ir neurons in the OVX-CT-pcpa-group was significantly more than that of the OVX-CT-group (p = 0.0283), which means pcpa inhibits calcitonin induced reduction of c-Fos production.	Fenclonine	43-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
18675266-8	2008	Depletion of serotonin, by the tryptophan hydroxylase inhibitor para-chlorophenylalanine, blocked the antidepressant-like effects of IGF-I.	Fenclonine	64-88	insulin-like growth factor 1	Rattus norvegicus	133-138
17870193-7	2008	Relaxin 3 gene expression in the NI significantly increased after 5-HT depletion by p-chlorophenylalanine (PCPA) administration.	Fenclonine	84-105	relaxin 3	Rattus norvegicus	0-9
17653110-6	2008	Block of serotonin transporter (SERT) with citalopram or 5-HT depletion with (+/-)-p-chlorophenylalanine pretreatment partially inhibited the ESP MDMA.	Fenclonine	77-104	solute carrier family 6 member 4	Rattus norvegicus	9-30
17653110-6	2008	Block of serotonin transporter (SERT) with citalopram or 5-HT depletion with (+/-)-p-chlorophenylalanine pretreatment partially inhibited the ESP MDMA.	Fenclonine	77-104	solute carrier family 6 member 4	Rattus norvegicus	32-36
18241894-8	2008	This depletion of 5-HT may underpin the increase in 5-HT(2A) receptor function because in wildtype mice 5-HT depletion using the 5-HT synthesis inhibitor, p-chlorophenylalanine, enhanced the head twitch response to DOI.	Fenclonine	155-176	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	52-69
17870193-7	2008	Relaxin 3 gene expression in the NI significantly increased after 5-HT depletion by p-chlorophenylalanine (PCPA) administration.	Fenclonine	107-111	relaxin 3	Rattus norvegicus	0-9
17675372-6	2007	The Tph inhibitor p-chlorophenylalanine (100 mgxkg(-1)xday(-1)) further improved these parameters.	Fenclonine	18-39	tryptophan hydroxylase 1	Mus musculus	4-7