PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29203642-6	2018	These results strongly indicate that PIPKIalpha interaction and Star-PAP S6 phosphorylation are required for Star-PAP-mediated regulation of cancer cell invasion and give specificity to target anti-invasive gene expression.	pipkialpha	37-47	terminal uridylyl transferase 1, U6 snRNA-specific	Homo sapiens	109-117
31235839-8	2019	Functionally, deleting or blocking the IQ3 motif inhibits cell proliferation, invasion, and migration in a non-additive manner to a PIPKIalpha inhibitor, establishing the functional specificity of IQ3 motif towards the PI3K-Akt pathway.	pipkialpha	132-142	AKT serine/threonine kinase 1	Homo sapiens	224-227
22244330-4	2012	PKCdelta binds the PI4,5P(2)-generating enzyme PIPKIalpha, which is essential for PKCdelta interaction with the Star-PAP complex, and PKCdelta activity is directly stimulated by PI4,5P(2).	pipkialpha	47-57	protein kinase C delta	Homo sapiens	0-8
27870828-3	2016	In this pathway, class I phosphatidylinositol-3-OH kinase (PI(3)K) is assembled by IQGAP1 with PI(4)KIIIalpha and PIPKIalpha, which sequentially generate PtdIns(3,4,5)P3 from phosphatidylinositol.	pipkialpha	114-124	IQ motif containing GTPase activating protein 1	Homo sapiens	83-89
22244330-4	2012	PKCdelta binds the PI4,5P(2)-generating enzyme PIPKIalpha, which is essential for PKCdelta interaction with the Star-PAP complex, and PKCdelta activity is directly stimulated by PI4,5P(2).	pipkialpha	47-57	protein kinase C delta	Homo sapiens	82-90
22244330-4	2012	PKCdelta binds the PI4,5P(2)-generating enzyme PIPKIalpha, which is essential for PKCdelta interaction with the Star-PAP complex, and PKCdelta activity is directly stimulated by PI4,5P(2).	pipkialpha	47-57	terminal uridylyl transferase 1, U6 snRNA-specific	Homo sapiens	112-120
22244330-4	2012	PKCdelta binds the PI4,5P(2)-generating enzyme PIPKIalpha, which is essential for PKCdelta interaction with the Star-PAP complex, and PKCdelta activity is directly stimulated by PI4,5P(2).	pipkialpha	47-57	protein kinase C delta	Homo sapiens	82-90
15870270-6	2005	Localization of PI(4,5)P2 synthesis and PIPKIalpha in the leading lamellipodia and membrane ruffles, respectively, of migrating Ajuba(-/-) MEFs was impaired.	pipkialpha	40-50	ajuba LIM protein	Mus musculus	128-133
16499229-8	2006	PIPKIalpha is thus a negative regulator of Fc(epsilon)RI-mediated cellular responses and anaphylaxis which functions by controlling the actin cytoskeleton and dynamics of Fc(epsilon)RI signaling.	pipkialpha	0-10	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	43-56
16499229-8	2006	PIPKIalpha is thus a negative regulator of Fc(epsilon)RI-mediated cellular responses and anaphylaxis which functions by controlling the actin cytoskeleton and dynamics of Fc(epsilon)RI signaling.	pipkialpha	0-10	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	171-184
18305108-2	2008	Star-PAP activity is directly modulated by the PIPKIalpha product phosphatidylinositol 4,5-bisphosphate (PI-4,5-P(2)), linking nuclear phosphoinositide signaling to gene expression.	pipkialpha	47-57	terminal uridylyl transferase 1, U6 snRNA-specific	Homo sapiens	0-8
15870270-7	2005	In vitro, Ajuba dramatically activated the enzymatic activity of PIPKIalpha while inhibiting the activity of PIPKIIbeta.	pipkialpha	65-75	ajuba LIM protein	Mus musculus	10-15
12682053-8	2003	PIPKIalpha-mediated formation of actin foci was independent of both Rac1 and phosphatidylinositol 3-kinase activities.	pipkialpha	0-10	Rac family small GTPase 1	Homo sapiens	68-72
12682053-9	2003	Significantly, coexpression of dominant active Rac1 with PIPKIalpha in PDGF-stimulated cells resulted in membrane ruffling.	pipkialpha	57-67	Rac family small GTPase 1	Homo sapiens	47-51
12682053-10	2003	The PDGF- and Rac1-stimulated ruffling was inhibited by expression of kinase-dead PIPKIalpha.	pipkialpha	82-92	Rac family small GTPase 1	Homo sapiens	14-18
11087761-6	2001	Activation of PIPKIalpha was induced by dephosphorylation, which was catalyzed by an okadaic acid-sensitive phosphatase, protein phosphatase 1 (PP1).	pipkialpha	14-24	protein phosphatase 1 catalytic subunit gamma	Mus musculus	121-142
11087761-6	2001	Activation of PIPKIalpha was induced by dephosphorylation, which was catalyzed by an okadaic acid-sensitive phosphatase, protein phosphatase 1 (PP1).	pipkialpha	14-24	protein phosphatase 1 catalytic subunit gamma	Mus musculus	144-147
11087761-8	2001	These results strongly suggest that activity of PIPKIalpha in NIH 3T3 cells is regulated by the reversible balance between PKA-dependent phosphorylation and PP1-dependent dephosphorylation.	pipkialpha	48-58	protein phosphatase 1 catalytic subunit gamma	Mus musculus	157-160