PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11427024-1	2001	In this study, bovine serum albumin (BSA) was covalently immobilized onto the surfaces of methyl methacrylate/methyl acrylic acid core-shell latex particles by the carbodiimide method, and the variation of the zeta potential of the BSA-latex complex as a function of the amount of BSA immobilized was measured.	Carbodiimides	164-176	albumin	Homo sapiens	22-35
11581214-4	2001	METHODS: The mitomycin C (MMC)-dextran (MMCD) conjugate was synthesized with a carbodiimide-catalyzed reaction.	Carbodiimides	79-91	ethylmalonyl-CoA decarboxylase 1	Rattus norvegicus	40-44
11511035-1	2001	We have conjugated bovine serum albumin (BSA) to poly(N-isopropylacrylamide-co-acrylic acid) (poly(NIPAAm-AA)) by using water-soluble carbodiimide, and the effects of the bulk mass ratio of protein to polymer (r) on the formation of polymer-protein conjugates have been studied.	Carbodiimides	134-146	albumin	Mus musculus	26-39
11412105-1	2001	Carboxyl groups of bovine RNase A were amidated with ethylenediamine (to convert negative charges of carboxylate anions to positive ones), 2-aminoethanol (to eliminate negative charges), and taurine (to keep negative charges), respectively, by a carbodiimide reaction.	Carbodiimides	246-258	ribonuclease pancreatic	Bos taurus	26-33
10985729-1	2000	Spectral and time-resolved fluorescence properties as well as relative fluorescence quantum yields of carbodiimide derivatives of 2.5-diphenyloxazole (PPO) (prepared by H2S elimination from the corresponding thioureas), of some intermediates in the preparation, and of several other PPO derivatives were investigated in solution and in the solid state to test their suitability as solid scintillators.	Carbodiimides	102-114	protoporphyrinogen oxidase	Homo sapiens	151-154
11348704-6	2001	Both carbodiimide-mediated coupling and reductive amination were used to conjugate PRP to dissociated fimbriae.	Carbodiimides	5-17	major prion protein	Oryctolagus cuniculus	83-86
11289434-6	2001	In an on-line procedure in the flow, a specific antibody (MD-2) against IFN-gamma is covalently attached following carbodiimide/succinimide activation of the SAM.	Carbodiimides	115-127	interferon gamma	Homo sapiens	72-81
10987917-0	2000	Room temperature ring-opening cyclization reactions of 2-vinylaziridines with isocyanates, carbodiimides, and isothiocyanates catalyzed by 2-Vinylaziridines undergo cycloaddition reactions with various heterocumulenes, in the presence of [Pd(OAc)(2)] and PPh(3), at room temperature and 1 atm pressure, regioselectively affording five-membered ring products in moderate to high yields.	Carbodiimides	91-104	caveolin 1	Homo sapiens	255-261
10978155-7	2000	To characterize the binding interface between E. coli flavodoxin and methionine synthase, we have employed site-directed mutagenesis and chemical cross-linking using carbodiimide and N-hydroxysuccinimide.	Carbodiimides	166-178	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	69-88
10995272-1	2000	Bovine beta-lactoglobulin-carboxymethyl cyclodextrin (beta-LG-CMCyD) conjugate was prepared using water-soluble carbodiimide, in an effort to improve the functional properties of the protein.	Carbodiimides	112-124	beta-lactoglobulin	Bos taurus	7-25
10995272-1	2000	Bovine beta-lactoglobulin-carboxymethyl cyclodextrin (beta-LG-CMCyD) conjugate was prepared using water-soluble carbodiimide, in an effort to improve the functional properties of the protein.	Carbodiimides	112-124	beta-lactoglobulin	Bos taurus	54-61
10563790-2	1999	Carbodiimide-induced cross-linking between filamentous actin and myosin loop 3 took place only with the motor domain of skeletal muscle myosin and not with those of smooth muscle or D. discoideum myosin II.	Carbodiimides	0-12	myosin heavy chain 14	Homo sapiens	65-71
10888497-1	2000	Bovine beta-lactoglobulin (beta-LG) was conjugated to each of three cationic saccharides [glucosamine (GlcN), chitopentaose (CPO), and chitosan (CHS)] by means of a water-soluble carbodiimide or by the Maillard reaction in an effort to improve the functional properties of beta-LG.	Carbodiimides	179-191	beta-lactoglobulin	Bos taurus	7-25
10888497-1	2000	Bovine beta-lactoglobulin (beta-LG) was conjugated to each of three cationic saccharides [glucosamine (GlcN), chitopentaose (CPO), and chitosan (CHS)] by means of a water-soluble carbodiimide or by the Maillard reaction in an effort to improve the functional properties of beta-LG.	Carbodiimides	179-191	beta-lactoglobulin	Bos taurus	27-34
10714438-4	2000	The TMP was linked to bovine serum albumin (BSA) by carbodiimide reaction, and then modified with the OH.	Carbodiimides	52-64	albumin	Oryctolagus cuniculus	29-42
10563790-2	1999	Carbodiimide-induced cross-linking between filamentous actin and myosin loop 3 took place only with the motor domain of skeletal muscle myosin and not with those of smooth muscle or D. discoideum myosin II.	Carbodiimides	0-12	myosin heavy chain 14	Homo sapiens	136-142
10343396-3	1999	In the former case, OGCHI was bound to N,N"-disuccinimidyl carbonate-activated aminopropyl-silica gels, while in the latter case OGCHI activated by a water-soluble carbodiimide and N-hydroxysulfosuccinimide was bound to aminopropyl-silica gels.	Carbodiimides	164-176	orosomucoid 1 (ovoglycoprotein)	Gallus gallus	20-25
9799717-8	1998	(2) In some cases, such as beta-glucosidase and beta-galactosidase, it might be necessary to remove excess carbodi-imide before the addition of the enzyme to the activated matrix.	Carbodiimides	107-120	galactosidase beta 1	Homo sapiens	48-66
10343396-3	1999	In the former case, OGCHI was bound to N,N"-disuccinimidyl carbonate-activated aminopropyl-silica gels, while in the latter case OGCHI activated by a water-soluble carbodiimide and N-hydroxysulfosuccinimide was bound to aminopropyl-silica gels.	Carbodiimides	164-176	orosomucoid 1 (ovoglycoprotein)	Gallus gallus	129-134
9864467-4	1998	In the presence of soluble carbodiimide and N-hydroxysuccinimide, rabbit liver Hsp90 can be cross-linked with calmodulin, troponin C, troponin I, and calponin.	Carbodiimides	27-39	calmodulin	Oryctolagus cuniculus	110-120
9753439-8	1998	Both the mono- and pentaglutamate derivatives of 5-CHO-H4PteGlun were cross-linked to SHMT by a carbodiimide reaction to Lys-450 which resides in a stretch of Lys, His, and Arg residues.	Carbodiimides	96-108	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	86-90
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Carbodiimides	165-177	superoxide dismutase 1	Homo sapiens	12-15
9774539-2	1998	Rotary-shadowed images of acto-HMM molecules crosslinked using MBS or water-soluble carbodiimide showed that MBS-G-actin binds to the distal half of a myosin head (the region 14-15 nm away from the head-rod junction).	Carbodiimides	84-96	myosin heavy chain 14	Homo sapiens	151-157
9720886-6	1998	Covalent immobilization of bovine serum albumin (BSA), gamma-globulin (gamma-Gl) and alkaline phosphatase (APh) was achieved by coupling with a water soluble carbodiimide.	Carbodiimides	158-170	albumin	Homo sapiens	34-47
9502583-4	1997	This ELISA used an IgG fraction of a rabbit polyclonal anti-IgE antibody coupled to the carboxylated surface, which prior to coupling had been preactivated with a water soluble carbodiimide.	Carbodiimides	177-189	immunoglobulin heavy constant epsilon	Homo sapiens	60-63
9367166-1	1997	Immobilized metal ion affinity gel electrophoresis (IMAGE) has been applied to study the change of the surface histidines topography of RNase A when chemically glycosylated on exposed carboxylic groups with glucosamine using carbodiimide as cross-linker, under mild conditions.	Carbodiimides	225-237	ribonuclease A family member 1, pancreatic	Homo sapiens	136-143
9279893-3	1997	METHODS: PEG molecules with terminal hydrazide (Hz) moieties of molecular weight 2,000 (PEG2000-Hz) or 5,000 (PEG5000-Hz) Daltons were coupled to BDNF carboxyls using carbodiimide.	Carbodiimides	167-179	brain derived neurotrophic factor	Homo sapiens	146-150
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Carbodiimides	165-177	superoxide dismutase 1	Homo sapiens	43-46
8703976-9	1996	This carbodiimide labels both a F0-component of the inner membrane ATPase and outer membrane porin in a similar way as N,N"-dicyclohexylcarbodiimide (DCCD).	Carbodiimides	5-17	porin	Drosophila melanogaster	93-98
8815749-2	1996	A highly substituted G6PDH-folate conjugate was prepared by employing an N-hydroxysuccinimide/carbodiimide method.	Carbodiimides	94-106	glucose-6-phosphate dehydrogenase	Homo sapiens	21-26
7578092-1	1995	The interaction of heavy-chain isoforms of myosin subfragment-1 with actin was examined by cross-linking with carbodiimide (EDC).	Carbodiimides	110-122	myosin heavy chain 14	Homo sapiens	43-49
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Carbodiimides	199-211	cytochrome b5	Oryctolagus cuniculus	235-248
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Carbodiimides	199-211	cytochrome P450 2B4	Oryctolagus cuniculus	253-259
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Carbodiimides	199-211	cytochrome b5	Oryctolagus cuniculus	313-326
8561506-1	1996	We have been able to demonstrate that cytochrome b4 interacts closely with cytochrome P450 in the microsomal membrane, and that substrates can serve to order the interaction: Using the water-soluble carbodiimide EDC we could crosslink cytochrome b5 and CYP2B4 in microsomes from phenobarbital-treated rabbits and cytochrome b5 and CYP1A2 in microsomes from beta-naphthoflavone-treated animals.	Carbodiimides	199-211	cytochrome P450 1A2	Oryctolagus cuniculus	331-337
7811729-5	1995	Covalent crosslinking experiments using a water-soluble carbodiimide show that adrenodoxin crosslinks exclusively to the 30.6 kDa fragment, thus implicating the N-terminal region of adrenodoxin reductase in binding to the iron-sulfur protein.	Carbodiimides	56-68	ferredoxin reductase	Bos taurus	182-203
18623363-3	1995	Soybean trypsin inhibitor (STI) was easily immobilized on the PLS by a one-step carbodiimide reaction.	Carbodiimides	80-92	kunitz trypsin protease inhibitor	Glycine max	8-25
7765412-3	1994	Glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49) from Bakers" yeast was immobilized with the highest activity on polyacrylamide beads possessing carboxylic functional groups activated by a water-soluble carbodiimide.	Carbodiimides	249-261	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
8010953-9	1994	Treatment with glycine ethyl ester in the presence of carbodi-imide modified 86% of the carboxylate groups in osteopontin and reduced its inhibitory activity by 6-fold.	Carbodiimides	54-67	secreted phosphoprotein 1	Homo sapiens	110-121
8055932-0	1994	Carbodiimide modification enhances activity of pig pancreatic phospholipase A2.	Carbodiimides	0-12	LOC104974671	Bos taurus	62-78
8206242-0	1994	The thiourea insecticide diafenthiuron inhibits mitochondrial ATPase in vitro and in vivo by its carbodiimide product.	Carbodiimides	97-109	ATP synthase F1 subunit epsilon	Homo sapiens	48-68
7764637-6	1994	Bovine serum albumin (BSA) was covalently immobilized onto the magnetic P(St/NIPAM/MAA) latex particles with high efficiency by the carbodiimide method.	Carbodiimides	132-144	albumin	Homo sapiens	7-20
9346868-2	1994	Two syntheses of rat cpn10 were performed, the first using a classical carbodiimide-mediated double coupling protocol (Method A) and the second a more efficient HBTU/HOBT/single coupling procedure (Method B).	Carbodiimides	71-83	heat shock protein family E (Hsp10) member 1	Rattus norvegicus	21-26
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	44-63
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	65-69
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	181-185
8486648-1	1993	The mouse 90-kDa heat shock protein (HSP90) and Ca(2+)-calmodulin were cross-linked at an equimolar ratio using a carbodiimide zero-length cross-linker.	Carbodiimides	114-126	heat shock protein 86, pseudogene 1	Mus musculus	37-42
8098372-1	1993	A recombinant human tumour necrosis factor alpha (TNF) was conjugated to gelatin by means of carbodiimide to improve the in-vivo stability of TNF.	Carbodiimides	93-105	tumor necrosis factor	Homo sapiens	50-53
7679494-7	1993	Two other angiogenic molecules, basic fibroblast growth factor and tumor necrosis factor alpha, bind to 125I-labeled actin and can be crosslinked by a water-soluble carbodiimide.	Carbodiimides	165-177	actin epsilon 1	Bos taurus	117-122
8098372-1	1993	A recombinant human tumour necrosis factor alpha (TNF) was conjugated to gelatin by means of carbodiimide to improve the in-vivo stability of TNF.	Carbodiimides	93-105	tumor necrosis factor	Homo sapiens	142-145
1466764-0	1992	Chemical modification of interleukin-1 beta: biochemical characterization of a carbodiimide-catalyzed intramolecular cross-linked protein.	Carbodiimides	79-91	interleukin 1 beta	Homo sapiens	25-43
1416971-11	1992	Complex formation between the NADPH-cytochrome P450 reductase and cytochrome P450 LM2 monomers was not detected by recording the difference binding spectra of the reductase monomers with LM2 monomers or by treatment the mixture of the monomers of the proteins with the crosslinking reagent, water-soluble carbodiimide.	Carbodiimides	305-317	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	30-61
1416971-11	1992	Complex formation between the NADPH-cytochrome P450 reductase and cytochrome P450 LM2 monomers was not detected by recording the difference binding spectra of the reductase monomers with LM2 monomers or by treatment the mixture of the monomers of the proteins with the crosslinking reagent, water-soluble carbodiimide.	Carbodiimides	305-317	cytochrome P450 2B4	Oryctolagus cuniculus	66-85
1329987-1	1992	Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide.	Carbodiimides	180-192	thrombomodulin	Homo sapiens	6-20
1329987-1	1992	Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide.	Carbodiimides	180-192	thrombomodulin	Homo sapiens	22-24
1324717-2	1992	A carbodiimide promotes noninvasive cross-linking between amino groups surrounding the exposed heme edge in zinc cytochrome c and carboxylic groups in the acidic patch in plastocyanin.	Carbodiimides	2-14	cytochrome c, somatic	Homo sapiens	113-125
1327167-1	1992	Carbodiimide-activated coupling chemistry has been used to covalently attach 1,1"-dicarboxyferrocene (dcFc) to the epsilon-amine of surface lysine residues of horse heart cytochrome c.	Carbodiimides	0-12	cytochrome c, somatic	Equus caballus	171-183
1457864-4	1992	RGD ALB was prepared via a coupling reaction of albumin with pentapeptide (GRGDS; Gly-RGD-Ser) by water soluble carbodiimide.	Carbodiimides	112-124	albumin	Bos taurus	4-7
1428521-5	1992	The effectiveness of this new procedure using the two carbodiimide additives in the synthesis of biologically active peptides was assessed by the preparation of a protected Leu-enkephalin.	Carbodiimides	54-66	prodynorphin	Homo sapiens	173-187
1373153-3	1992	Intravenous injection of GPMBP coupled to syngeneic splenocytes using the chemical cross-linker carbodiimide was effective in completely abrogating the expression of clinical EAE in rats that received MBP-specific T cells 2 days previously.	Carbodiimides	96-108	myelin basic protein	Rattus norvegicus	27-30
1833052-1	1991	A recombinant human alpha-interferon A/D (IFN), also known to be effective in mice, was conjugated to gelatin with a water-soluble carbodiimide.	Carbodiimides	131-143	interferon alpha 1	Homo sapiens	20-46
1757114-1	1991	We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method.	Carbodiimides	121-133	taste 2 receptor member 18 pseudogene	Homo sapiens	68-71
1645525-0	1991	Some reactions of carbon monoxide and oxygen with carbodi-imide-modified cytochrome c.	Carbodiimides	50-63	cytochrome c, somatic	Equus caballus	73-85
1654092-2	1991	Cytochrome c and plastocyanin form an electrostatic complex, which can be reinforced by amide bonds in the presence of a carbodiimide.	Carbodiimides	121-133	cytochrome c, somatic	Homo sapiens	0-12
1907919-6	1991	It is shown that fixation of the AC with carbodiimide or treatment of the AC with UV light greatly reduces their capacity to induce (in combination with IL2) the synthesis of IFN-gamma by T cells.	Carbodiimides	41-53	interleukin 2	Mus musculus	153-156
1907919-6	1991	It is shown that fixation of the AC with carbodiimide or treatment of the AC with UV light greatly reduces their capacity to induce (in combination with IL2) the synthesis of IFN-gamma by T cells.	Carbodiimides	41-53	interferon gamma	Mus musculus	175-184
2035536-0	1991	A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.	Carbodiimides	182-194	collagen type I alpha 2 chain	Homo sapiens	26-44
2035536-0	1991	A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.	Carbodiimides	182-194	collagen type I alpha 1 chain	Homo sapiens	46-52
1672519-8	1991	Aminopeptidase N was rapidly inactivated by 2,3-butanedione and diethylpyrocarbonate and partially inactivated by N-acetylimidazole, diazoacetamide and a soluble carbodiimide, suggesting the presence of functional arginyl, histidyl, tyrosyl and aspartyl/glutamyl residues.	Carbodiimides	162-174	alanyl aminopeptidase, membrane	Homo sapiens	0-16
2006162-3	1991	125I-Ang can be crosslinked efficiently to AngBP by a water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbo-diimide.	Carbodiimides	68-80	ANG	Bos taurus	5-8
1826080-11	1991	Inhibition experiments with phenylmethanesulphonyl fluoride, carbodi-imide, dichloroisocoumarin and competitive peptide inhibitors demonstrated that Lp(a) has enzyme activity that closely resembles that of serine proteinases.	Carbodiimides	61-74	lipoprotein(a)	Homo sapiens	149-154
2148693-0	1990	Reaction of a carbodiimide adduct of ATP at the active site of sarcoplasmic reticulum calcium ATPase.	Carbodiimides	14-26	dynein axonemal heavy chain 8	Homo sapiens	94-100
1997319-0	1991	Conformational change of turkey-gizzard caldesmon induced by specific chemical modification with carbodiimide.	Carbodiimides	97-109	caldesmon 1	Gallus gallus	40-49
2123873-1	1990	Preparations of amidinated cytochrome b5 and cytochrome b5 reductase, cross-linked by using a soluble carbodiimide to promote the formation of covalent bonds between carboxyl groups of the hemeprotein and nucleophilic residues of the flavoprotein at the surfaces involved in protein-protein contacts during electron transfer, have been used to characterize the charge pair interactions that occur during electron transfer between the free proteins.	Carbodiimides	102-114	cytochrome b5 type A	Homo sapiens	27-40
2123873-1	1990	Preparations of amidinated cytochrome b5 and cytochrome b5 reductase, cross-linked by using a soluble carbodiimide to promote the formation of covalent bonds between carboxyl groups of the hemeprotein and nucleophilic residues of the flavoprotein at the surfaces involved in protein-protein contacts during electron transfer, have been used to characterize the charge pair interactions that occur during electron transfer between the free proteins.	Carbodiimides	102-114	cytochrome b5 type A	Homo sapiens	45-58
2151408-1	1990	Plasmin was immobilized on collageno-elastic tubes (CET) using carbodiimide as the cross-linking agent.	Carbodiimides	63-75	plasminogen	Homo sapiens	0-7
1705147-3	1990	The binding of trisgalactosylglycine residues to bovine serum albumin and ovalbumin was performed by the carbodiimide method; amyloglucosidase galactosylation was performed by using the reductive amination method.	Carbodiimides	105-117	albumin	Homo sapiens	56-69
2115458-2	1990	The immunogen is TRH-BSA, the production of which is based on the formation of an amide bond using carbodiimide (EDC).	Carbodiimides	99-111	thyrotropin releasing hormone	Rattus norvegicus	17-20
2165402-3	1990	Serum albumin was treated with the water-soluble carbodiimide N-ethyl-N"-(3-dimethylaminopropyl) carbodiimide hydrochloride and the resultant positively charged N-acylurea albumin covalently conjugated to insulin by glutaraldehyde cross-linkage.	Carbodiimides	49-61	albumin	Homo sapiens	0-13
2224891-3	1990	Ester groups were removed from the carbohydrate moieties with methanolic hydrazine, to give the TN and T antigen glycopeptides which were coupled to bovine serum albumin (BSA) via a carbodi-imide procedure and without any spacer groups.	Carbodiimides	182-195	albumin	Homo sapiens	156-169
2374709-2	1990	The solution structure of human U1 snRNA was investigated by using base-specific chemical probes (dimethylsulfate, carbodiimide, diethylpyrocarbonate) and RNase V1.	Carbodiimides	115-127	RNA, U1 small nuclear 1	Homo sapiens	32-40
1702692-2	1990	UC-dextran conjugates (UC-D) synthesized by four methods, periodate oxidation, cyanogen bromide, carbodiimide and cyanuric chloride largely retained the UC enzymatic activity depending on the extent to which they modified amino groups.	Carbodiimides	97-109	urate oxidase	Rattus norvegicus	0-2
1702692-2	1990	UC-dextran conjugates (UC-D) synthesized by four methods, periodate oxidation, cyanogen bromide, carbodiimide and cyanuric chloride largely retained the UC enzymatic activity depending on the extent to which they modified amino groups.	Carbodiimides	97-109	urate oxidase	Rattus norvegicus	23-25
1702692-2	1990	UC-dextran conjugates (UC-D) synthesized by four methods, periodate oxidation, cyanogen bromide, carbodiimide and cyanuric chloride largely retained the UC enzymatic activity depending on the extent to which they modified amino groups.	Carbodiimides	97-109	urate oxidase	Rattus norvegicus	23-25
33793235-0	2021	Catalytic Carbodiimide Guanylation by a Nucleophilic, High Spin Iron(II) Imido Complex.	Carbodiimides	10-22	spindlin 1	Homo sapiens	59-63
2177851-2	1990	The procedure involves specific labeling of NGF receptors by covalent crosslinking to 125I-NGF with a carbodiimide reagent, and subsequent immunoprecipitation of the detergent-extracted 125I-NGF-receptor complexes with the 20.4 IgG.	Carbodiimides	102-114	nerve growth factor	Homo sapiens	44-47
2342486-0	1990	Carbodiimide crosslinking of human C1q and rabbit IgG.	Carbodiimides	0-12	complement C1q A chain	Homo sapiens	35-38
2298747-6	1990	This region is also known to serve for the carbodiimide-mediated cross-linking of the myosin subfragment-1 heavy chain (Sutoh, K. (1982) Biochemistry 21, 3654-3661).	Carbodiimides	43-55	myosin heavy chain 14	Homo sapiens	86-92
34424718-3	2021	Furthermore, we have identified two carbodiimides, TBEC and EDC HCl, whose reaction with OxymaPure is exempt from HCN formation.	Carbodiimides	36-49	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	114-117
33807529-2	2021	In this study, chitosan (CS) was functionalized with three kinds of hydroxycinnamic acids (p-coumaric acid, caffeic acid and ferulic acid) through the carbodiimide-mediated grafting method.	Carbodiimides	151-163	citrate synthase	Homo sapiens	25-27
34802226-3	2021	The resulting hybrid architecture (N-GQD@SWCNHs) functioned as an exceptional base for the immobilization of antibody (Anti-AFP) through carbodiimide reaction with good stability and bioactivity.	Carbodiimides	137-149	alpha fetoprotein	Homo sapiens	124-127
34252797-4	2021	Carbodiimide-activated amidation reactions were used for the functionalization of graphene quantum dot with Bovine Serum Albumin.	Carbodiimides	0-12	albumin	Homo sapiens	115-128
34712292-2	2021	Methods: PLGA nanoparticles were prepared by a double emulsification method, and the MUC1 aptamer was connected to the PLGA nanoparticles by the carbodiimide method to obtain an "aptamer-PLGA nanoparticle" targeted phase change contrast agent.	Carbodiimides	145-157	mucin 1, cell surface associated	Homo sapiens	85-89
2480980-2	1989	For antibody production, the O-phosphorylated derivative of tyrosine, threonine, or serine was covalently linked to succinylated bovine albumin via the carbodiimide reaction.	Carbodiimides	152-164	albumin	Bos taurus	136-143
35414378-5	2022	The fast electron transfer, excellent redox property, and high surface-to-volume ratio of NiO Nps/CeCuOx based sensing electrode facilitate the successful immobilization of anti-LCN2 by carbodiimide coupling.	Carbodiimides	186-198	lipocalin 2	Homo sapiens	178-182
2558010-0	1989	Crosslinking of cytochrome c and cytochrome b5 with a water-soluble carbodiimide.	Carbodiimides	68-80	LOC104968582	Bos taurus	16-28
2558010-0	1989	Crosslinking of cytochrome c and cytochrome b5 with a water-soluble carbodiimide.	Carbodiimides	68-80	cytochrome b5 type A	Bos taurus	33-46
2558010-2	1989	A water soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), has been used to crosslink horse heart cytochrome c and trypsin-solubilized bovine liver microsomal cytochrome b5.	Carbodiimides	16-28	cytochrome c, somatic	Equus caballus	122-134
2558010-2	1989	A water soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), has been used to crosslink horse heart cytochrome c and trypsin-solubilized bovine liver microsomal cytochrome b5.	Carbodiimides	16-28	cytochrome b5 type A	Bos taurus	183-196
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Carbodiimides	18-30	pancreatic lipase	Equus caballus	164-170
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Carbodiimides	18-30	pancreatic lipase	Equus caballus	174-180
2583289-1	1989	The water soluble carbodiimide N-cyclohexyl-N"-2-morpholinoethyl-carbodiimide-methyl-p-toluolsulfona te was found to effectively covalently cross-link pancreatic colipase to lipase as evidenced by Western blotting experiments using antibodies directed either against lipase or colipase.	Carbodiimides	18-30	colipase	Equus caballus	162-170
2583289-4	1989	The specificity of the lipase-colipase binding was further supported by the very low amount of cross-linked products when lipase or colipase alone were incubated in the presence of carbodiimide.	Carbodiimides	181-193	pancreatic lipase	Equus caballus	23-29
2583289-4	1989	The specificity of the lipase-colipase binding was further supported by the very low amount of cross-linked products when lipase or colipase alone were incubated in the presence of carbodiimide.	Carbodiimides	181-193	colipase	Equus caballus	30-38
2583289-4	1989	The specificity of the lipase-colipase binding was further supported by the very low amount of cross-linked products when lipase or colipase alone were incubated in the presence of carbodiimide.	Carbodiimides	181-193	pancreatic lipase	Equus caballus	32-38
2583289-4	1989	The specificity of the lipase-colipase binding was further supported by the very low amount of cross-linked products when lipase or colipase alone were incubated in the presence of carbodiimide.	Carbodiimides	181-193	colipase	Equus caballus	132-140
2583289-5	1989	The formation of a covalent lipase-colipase complex in the presence of carbodiimide clearly demonstrates that the binding between both proteins involves ion pairing.	Carbodiimides	71-83	pancreatic lipase	Equus caballus	28-34
2552917-1	1989	Pig pancreas carboxypeptidase B has been immobilized by covalent attachment to a polyacrylamide-type bead support possessing carboxylic functional groups activated by water-soluble carbodiimide.	Carbodiimides	181-193	carboxypeptidase B1	Sus scrofa	13-31
2792382-0	1989	Inactivation of human thrombin by water-soluble carbodiimides.	Carbodiimides	48-61	coagulation factor II, thrombin	Homo sapiens	22-30
2777275-3	1989	A colchicine bovine serum albumin (Col-BSA) conjugate, prepared using a water soluble carbodiimide coupling technique, formed the basis of an enzyme linked immunosorbent assay used for screening hybridomas for colchicine specific antibody secretion and for determining the relative affinity and specificity profile of the monoclonal antibodies.	Carbodiimides	86-98	albumin	Mus musculus	20-33
2472293-1	1989	Negatively charged carboxyl groups of mitochondrial porin have been converted into positively charged ones by means of reaction with water-soluble carbodiimide in the presence of ethylenediamine.	Carbodiimides	147-159	voltage dependent anion channel 1	Homo sapiens	52-57
2795424-0	1989	[Reaction of carbodiimide for the introduction of p-bis(2-chloroethyl)amino-L-phenylalanine to lysozyme].	Carbodiimides	13-25	lysozyme	Homo sapiens	95-104
2568459-1	1989	Physiochemical parameters have been determined for a series of methotrexate-bovine serum albumin conjugates produced using a water-soluble carbodiimide.	Carbodiimides	139-151	albumin	Homo sapiens	83-96
2583289-5	1989	The formation of a covalent lipase-colipase complex in the presence of carbodiimide clearly demonstrates that the binding between both proteins involves ion pairing.	Carbodiimides	71-83	colipase	Equus caballus	35-43
2752065-4	1989	The cytochrome P-450scc-cytochrome b5 complex may be cross-linked with water-soluble carbodiimide.	Carbodiimides	85-97	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	4-23
2752065-4	1989	The cytochrome P-450scc-cytochrome b5 complex may be cross-linked with water-soluble carbodiimide.	Carbodiimides	85-97	cytochrome b5 type A	Homo sapiens	24-37
2541766-1	1989	Horse heart cytochrome c and French bean plastocyanin are cross-linked one-to-one by a carbodiimide [Geren, L. M., Stonehuerner, J., Davis, D. J., & Millett, F. (1983) Biochim.	Carbodiimides	87-99	cytochrome c, somatic	Equus caballus	12-24
2733028-5	1989	These modified polymers were then covalently linked either to monoclonal antimyosin antibody or to its Fab fragment by means of a water soluble carbodiimide.	Carbodiimides	144-156	FA complementation group B	Homo sapiens	103-106
11537376-5	1989	The reaction of the 5"-AMP with water soluble  carbodiimide in the presence of Na(+)-montmorillonite results in the formation of 2",5"-pApA (18.9%), 3",5"-pApA (11%), and AppA (4.8%).	Carbodiimides	47-59	pappalysin 1	Homo sapiens	135-139
11537376-5	1989	The reaction of the 5"-AMP with water soluble  carbodiimide in the presence of Na(+)-montmorillonite results in the formation of 2",5"-pApA (18.9%), 3",5"-pApA (11%), and AppA (4.8%).	Carbodiimides	47-59	pappalysin 1	Homo sapiens	155-159
2972318-0	1988	The effect of calmodulin on the interaction of carbodiimides with the purified human erythrocyte (Ca2+ + Mg2+)-ATPase.	Carbodiimides	47-60	calmodulin 1	Homo sapiens	14-24
2972318-5	1988	In the absence of calmodulin, 6.7 molecules of N,N"-dicyclohexyl[14C]carbodiimide covalently bound to each molecule of Ca2+-ATPase; in the presence of calmodulin, the number of molecules of carbodiimide bound was 13.1.	Carbodiimides	69-81	calmodulin 1	Homo sapiens	151-161
2845796-1	1988	Angiotensin II (ANG II) was conjugated to polystyrene Latex fluorescent microspheres (0.5 or 0.05 micron diam) with carbodiimide.	Carbodiimides	116-128	angiotensinogen	Homo sapiens	0-14
2845796-1	1988	Angiotensin II (ANG II) was conjugated to polystyrene Latex fluorescent microspheres (0.5 or 0.05 micron diam) with carbodiimide.	Carbodiimides	116-128	angiotensinogen	Homo sapiens	16-22
3167185-2	1988	Thrombin was modified by carbodiimide and 1, 12-dodecamethylenediamine.	Carbodiimides	25-37	coagulation factor II, thrombin	Homo sapiens	0-8
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Carbodiimides	150-162	cytochrome p450 oxidoreductase	Homo sapiens	41-73
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Carbodiimides	150-162	cytochrome b5 type A	Homo sapiens	85-98
2847775-1	1988	Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed.	Carbodiimides	150-162	cytochrome c, somatic	Homo sapiens	102-114
3182767-0	1988	The sites on calmodulin cross-linked to myosin light chain kinase and troponin I with water-soluble carbodiimide.	Carbodiimides	100-112	CaM5	Triticum aestivum	13-23
3375071-2	1988	Condensation on a tetradecanucleotide template of hexa(penta)- and undecanucleotides differing only in the terminal nucleoside residue have been performed using water-soluble carbodiimide as a condensing agent.	Carbodiimides	175-187	hexosaminidase subunit alpha	Homo sapiens	50-54
3435944-0	1987	Reactivities of various amines in the modifications of acetic acid and aspartic acid-101 of lysozyme in the carbodiimide reaction.	Carbodiimides	108-120	lysozyme	Homo sapiens	92-100
3348805-0	1988	Inactivation of bovine thrombin by water-soluble carbodiimides: the essential carboxyl group has a pKa of 5.51.	Carbodiimides	49-62	coagulation factor II, thrombin	Bos taurus	23-31
2440893-1	1987	Plasmin was immobilized on collagenous substrates using carbodiimide as a linking agent.	Carbodiimides	56-68	plasminogen	Homo sapiens	0-7
2820477-0	1987	Proton NMR and electrophoretic studies of the covalent complex formed by cross-linking yeast cytochrome c peroxidase and horse cytochrome c with a water-soluble carbodiimide.	Carbodiimides	161-173	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	93-116
2820477-0	1987	Proton NMR and electrophoretic studies of the covalent complex formed by cross-linking yeast cytochrome c peroxidase and horse cytochrome c with a water-soluble carbodiimide.	Carbodiimides	161-173	cytochrome c, somatic	Equus caballus	93-105
2841939-1	1987	Carboxyl groups of NADPH-cytochrome P-450 reductase have been modified with the water-soluble carbodiimide EDC.	Carbodiimides	94-106	cytochrome p450 oxidoreductase	Homo sapiens	19-51
3110049-2	1987	These polymers were then reacted with the amino groups on myosin-specific monoclonal antibody or its Fab using a water soluble carbodiimide.	Carbodiimides	127-139	FA complementation group B	Homo sapiens	101-104
3507704-0	1987	Highly controlled carbodiimide reaction for the modification of lysozyme.	Carbodiimides	18-30	lysozyme	Homo sapiens	64-72
3569402-3	1987	IgA, isolated from normal human serum, was aggregated by either N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP), glutaraldehyde, carbodiimide or heating.	Carbodiimides	133-145	IGA	Ovis aries	0-3
2820377-0	1987	Some electron-transfer reactions involving carbodi-imide-modified cytochrome c.	Carbodiimides	43-56	cytochrome c, somatic	Equus caballus	66-78
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Carbodiimides	142-154	nerve growth factor	Rattus norvegicus	187-190
3587924-5	1987	DHG was reacted with cysteine and subsequently coupled to serum albumin using the carbodiimide reaction.	Carbodiimides	82-94	albumin	Oryctolagus cuniculus	58-71
3801648-1	1987	Successive thrombin modification by carbodiimide and aliphatic diamines decreases esterase and fibrin-coagulating activity of the enzyme.	Carbodiimides	36-48	coagulation factor II, thrombin	Homo sapiens	11-19
3541934-1	1986	4"-Aminomethyl-4,5",8-trimethylpsoralen has been chemically conjugated to insulin using a carbodiimide derivative.	Carbodiimides	90-102	insulin	Homo sapiens	74-81
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Carbodiimides	142-154	nerve growth factor	Rattus norvegicus	194-197
3021771-2	1986	To specifically characterize the molecular identity of the high affinity site and to compare it with the low affinity site, the water-soluble carbodiimide EDC was used to cross-link 125I-NGF to NGF receptors on: rat PC12 cells, PC12nnr5 cells (PC12 mutants that have only low affinity NGF binding), SH-SY5Y human neuroblastoma cells (which have only high affinity binding sites), and cultured rat sympathetic ganglion cells.	Carbodiimides	142-154	nerve growth factor	Rattus norvegicus	194-197
3781744-2	1986	Modification of approximately one fifth of the carboxylate groups in bovine somatotropin with a water soluble carbodiimide caused loss of growth promoting potency pointing to the existence of residues related to the hormonal activity among those belonging to a fast reacting set.	Carbodiimides	110-122	somatotropin	Bos taurus	76-88
3524679-1	1986	Ferredoxin which had been modified with glycine ethylester in the presence of a water-soluble carbodiimide to the extent of one carboxyl-group modified per ferredoxin was subjected to peptide mapping in an attempt to locate the site(s) of modification.	Carbodiimides	94-106	ferredoxin reductase	Homo sapiens	0-10
3526340-2	1986	We used water-soluble carbodiimides to covalently attach the RNase S-peptide (residues 1-20) to [3H]RNase S-protein (residues 21-124) at unspecified locations.	Carbodiimides	22-35	vitronectin	Homo sapiens	106-115
2874801-1	1986	Hemin, having two carboxyl groups, was coupled with monomethoxypolyethylene glycol, PEG, through the ester bond formed with carbodiimide.	Carbodiimides	124-136	progestagen associated endometrial protein	Homo sapiens	84-87
3093409-5	1986	Also, the immunoperoxidase method of Factor VIII identification was applied to unfixed, acetone-fixed, and carbodiimide-fixed endothelial cell seeded vascular grafts.	Carbodiimides	107-119	coagulation factor VIII	Canis lupus familiaris	37-48
3002455-0	1986	The use of a water-soluble carbodiimide to study the interaction between Chromatium vinosum flavocytochrome c-552 and cytochrome c.	Carbodiimides	27-39	cytochrome c, somatic	Equus caballus	97-109
3964300-0	1986	Binding of DNA to albumin and transferrin modified by treatment with water-soluble carbodiimides.	Carbodiimides	83-96	serotransferrin	Bos taurus	30-41
3964300-1	1986	N-Acylurea derivatives of albumin and transferrin prepared with the water-soluble carbodiimides N-ethyl-N"-(3-dimethylaminopropyl)carbodiimide and N-ethyl-N"-(3-trimethylpropylammonium)carbodiimide iodide have been found to bind different types of DNA.	Carbodiimides	82-95	serotransferrin	Bos taurus	38-49
3964300-3	1986	In the case of iron-loaded transferrin, reactions with carbodiimides were in phosphate-buffered saline (pH 7.5) to prevent loss of iron from the protein.	Carbodiimides	55-68	serotransferrin	Bos taurus	27-38
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Carbodiimides	14-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-79
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Carbodiimides	14-26	cytochrome b5 type A	Homo sapiens	85-98
3080992-1	1986	Water-soluble carbodiimide-catalyzed cross-linking of purified cytochrome P-450 LM2, cytochrome b5, and NADPH-cytochrome P-450 reductase was used to identify stable complexes formed between these proteins.	Carbodiimides	14-26	cytochrome p450 oxidoreductase	Homo sapiens	104-136
2867817-3	1986	Carbodiimide-fixed glutamate-like, GLNase-like and AATase-like immunoreactivities were observed in neurons of the lateral, posterior interpositus, anterior interpositus and medial deep cerebellar nuclei.	Carbodiimides	0-12	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	51-57
2884084-1	1986	Synthetic cyclic somatostatin-14 (SRIF-14) was conjugated with carbodiimide onto hemocyanin to immunize rabbits, and anti-sera with high titers (1:5,000-100,000) and good sensitivity and specificity were obtained.	Carbodiimides	63-75	somatostatin	Homo sapiens	17-32
4074749-3	1985	Substantial cross-linking of adrenodoxin reductase with adrenodoxin was observed when water-soluble carbodiimide was used as cross-linking reagent.	Carbodiimides	100-112	ferredoxin reductase	Bos taurus	29-50
3836843-1	1985	The specific efficient anti-MTX antibody was obtained from the rabbits immunized with an artificial antigen produced by condensing MTX and bovine serum albumin in water-soluble carbodi-imide.	Carbodiimides	177-190	albumin	Oryctolagus cuniculus	146-159
2985577-3	1985	Essentially quantitative cross-linking of cytochrome c and flavodoxin was observed at low ionic strengths with the carbodiimide cross-linking reagent.	Carbodiimides	115-127	cytochrome c, somatic	Equus caballus	42-54
3929686-0	1985	NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.	Carbodiimides	141-153	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	0-32
3929686-0	1985	NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.	Carbodiimides	141-153	cytochrome b5	Oryctolagus cuniculus	33-46
4038319-1	1985	Modification of the polypeptide anthopleurin-A with a carbodiimide and glycine ethyl ester leads to the addition of nearly two Gly to AP-A.	Carbodiimides	54-66	glutamyl aminopeptidase	Homo sapiens	134-138
6432777-2	1984	Modification of the three carboxyl groups on adrenodoxin using a water-soluble carbodiimide (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) caused a weakening of the binding of this iron-sulfur protein to both its electron donor protein, adrenodoxin reductase, and its electron acceptor protein, cytochrome P-450scc.	Carbodiimides	79-91	ferredoxin reductase	Homo sapiens	238-259
3973461-4	1985	Antithrombin (AT) binding by heparinized PMA materials (compared with PMA control beads) ranged from no AT binding for the material heparinized with carbodiimide (PMA-Alb-Hep(EDC] to 3.6 micrograms/ml packed beads for the material heparinized by radical polymerization (PMA-MA-Hep).	Carbodiimides	149-161	serpin family C member 1	Homo sapiens	0-12
3900138-1	1985	Synthetic oxytocin (OT) conjugated to bovine thyroglobulin by the carbodiimide reaction was injected into rabbits to raise a high titre, specific OT antiserum which was then coupled to microcrystalline cellulose activated by cyanogen bromide.	Carbodiimides	66-78	oxytocin/neurophysin I prepropeptide	Homo sapiens	10-18
6097223-2	1984	Bovine somatotropin with an increasing number of its carboxylate groups modified by reaction with glycine methyl ester in the presence of a water-soluble carbodi-imide was tested for its activity in different bioassays.	Carbodiimides	154-167	somatotropin	Bos taurus	7-19
6432777-2	1984	Modification of the three carboxyl groups on adrenodoxin using a water-soluble carbodiimide (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) caused a weakening of the binding of this iron-sulfur protein to both its electron donor protein, adrenodoxin reductase, and its electron acceptor protein, cytochrome P-450scc.	Carbodiimides	79-91	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	296-315
6426521-1	1984	Human liver acid alpha-glucosidase (1,4-alpha-D-glucan glucohydrolase, EC 3.2.1.3) was modified with water soluble carbodiimide in the presence of p-aminophenyl-beta-D-galactopyranoside.	Carbodiimides	115-127	alpha-glucosidase	Ricinus communis	17-34
6733083-1	1984	The interaction of actin and rabbit subfragment 1 has been reexamined by using a carbodiimide cross-linking reagent.	Carbodiimides	81-93	actin	Oryctolagus cuniculus	19-24
6729936-6	1984	On the basis of an increased inhibition by sialoglycoproteins after periodate oxidation and carbodiimide treatment, respectively, three anti- Pr2 and five anti-Pr3 were found.	Carbodiimides	92-104	proteinase 3	Homo sapiens	160-163
6699018-1	1984	A water-soluble carbodiimide has been used to promote the formation of amide bonds between carboxyl residues on cytochrome b5 and lysyl residues on cytochrome b5 reductase.	Carbodiimides	16-28	cytochrome b5 type A	Homo sapiens	112-125
6699018-1	1984	A water-soluble carbodiimide has been used to promote the formation of amide bonds between carboxyl residues on cytochrome b5 and lysyl residues on cytochrome b5 reductase.	Carbodiimides	16-28	cytochrome b5 type A	Homo sapiens	148-161
16663354-3	1983	In contrast, trimethyltin chloride strongly inhibited the activity of Hevea tonoplast ATPase.Among the different carbodiimides tested, which strongly inhibit the Hevea tonoplast ATPase, N,N"-dicyclohexylcarbodiimide was the most inhibitory.	Carbodiimides	113-126	dynein axonemal heavy chain 8	Homo sapiens	86-92
6725248-1	1984	The water-soluble carbodiimide, N-ethyl-3-(3-dimethylaminopropyl)carbodiimide was found to effectively cross-link ferredoxin to ferredoxin-NADP+ reductase.	Carbodiimides	18-30	ferredoxin reductase	Homo sapiens	128-154
16663354-3	1983	In contrast, trimethyltin chloride strongly inhibited the activity of Hevea tonoplast ATPase.Among the different carbodiimides tested, which strongly inhibit the Hevea tonoplast ATPase, N,N"-dicyclohexylcarbodiimide was the most inhibitory.	Carbodiimides	113-126	dynein axonemal heavy chain 8	Homo sapiens	178-184
6196413-1	1983	Horse anti-alpha-fetoprotein was coupled to CM-cellulose discs by a modified carbodiimide reaction.	Carbodiimides	77-89	alpha fetoprotein	Homo sapiens	11-28
6315005-0	1983	Interaction between cytochrome c and ubiquinone-cytochrome c oxidoreductase: a study with water-soluble carbodiimides.	Carbodiimides	104-117	cytochrome c, somatic	Homo sapiens	20-32
6315005-0	1983	Interaction between cytochrome c and ubiquinone-cytochrome c oxidoreductase: a study with water-soluble carbodiimides.	Carbodiimides	104-117	cytochrome c, somatic	Homo sapiens	48-60
6315005-1	1983	The role of carboxyl groups on the interaction between ubiquinone-cytochrome c oxidoreductase (Complex III) and cytochrome c has been probed using the two water-soluble carbodiimides EDC (1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide) and CMC (1-cyclohexyl-3-(2-morpholinyl-4-ethyl) carbodiimide metho-p-toluensulphonate).	Carbodiimides	169-182	cytochrome c, somatic	Homo sapiens	66-78
6315005-1	1983	The role of carboxyl groups on the interaction between ubiquinone-cytochrome c oxidoreductase (Complex III) and cytochrome c has been probed using the two water-soluble carbodiimides EDC (1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide) and CMC (1-cyclohexyl-3-(2-morpholinyl-4-ethyl) carbodiimide metho-p-toluensulphonate).	Carbodiimides	169-182	cytochrome c, somatic	Homo sapiens	112-124
6315005-4	1983	2) The enzyme activity decreases during the carbodiimide treatment and the extent of inhibition is larger in the presence of cytochrome c.	Carbodiimides	44-56	cytochrome c, somatic	Homo sapiens	125-137
6315005-5	1983	3) Cytochrome c, equimolar with the enzyme, cross-links to cytochrome c1 and subunit VIII via the carbodiimide-activated carboxyl groups.	Carbodiimides	98-110	cytochrome c, somatic	Homo sapiens	3-15
6307354-0	1983	The use of a water-soluble carbodiimide to cross-link cytochrome c to plastocyanin.	Carbodiimides	27-39	LOC104968582	Bos taurus	54-66
6307354-1	1983	A water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, has been used to cross-link horse heart cytochrome c to spinach chloroplast plastocyanin.	Carbodiimides	16-28	cytochrome c, somatic	Equus caballus	117-129
6307354-5	1983	We propose that the carbodiimide promoted the formation of amide cross-links between lysine amino groups surrounding the heme crevice of cytochrome c and complementary carboxyl groups on plastocyanin.	Carbodiimides	20-32	LOC104968582	Bos taurus	137-149
6874113-1	1983	Desferrioxamine-human serum albumin conjugate was prepared at pH 4.7 using a water-soluble carbodiimide and at pH 7.8 using glutaraldehyde.	Carbodiimides	91-103	albumin	Homo sapiens	22-35
6601061-1	1983	Conjugates were prepared by carbodiimide-mediated coupling of adipic acid hydrazide derivatives of Haemophilus influenzae type b (Hib), Escherichia coli K100, and pneumococcal 6A (Pn6A) polysaccharides with tetanus toxoid (TT), as an example of a "useful" carrier, and horseshoe crab hemocyanin (HCH), as an example of a "nonsense" carrier.	Carbodiimides	28-40	C1q-like 3	Mus musculus	153-157
6434797-0	1983	Production of new type of antisera to thyrotropin releasing hormone (TRH) using carbodiimide coupling and an application to immunohistochemistry.	Carbodiimides	80-92	thyrotropin releasing hormone	Homo sapiens	38-67
6340090-3	1983	The NAD-insulin conjugate was obtained by covalent binding of the C(6)-aminogroup modified cofactor with insulin by means of soluble carbodiimide.	Carbodiimides	133-145	INS	Equus caballus	8-15
6297972-1	1982	Two water-soluble carbodiimides, differing in molecular dimensions, have been used to characterize the cytochrome c binding site of bovine heart cytochrome c oxidase.	Carbodiimides	18-31	LOC104968582	Bos taurus	103-115
6297972-1	1982	Two water-soluble carbodiimides, differing in molecular dimensions, have been used to characterize the cytochrome c binding site of bovine heart cytochrome c oxidase.	Carbodiimides	18-31	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	145-165
6183733-2	1982	Haemagglutination inhibition studies disclosed the subspecificity anti-Pr3, since the cold agglutinin was strongly inhibited by carbodiimide-treated erythrocyte glycoproteins.	Carbodiimides	128-140	proteinase 3	Homo sapiens	71-74
6297972-3	1982	Carboxyl groups present in subunit II, VII and polypeptide c, are protected from modification when cytochrome c, equimolar to oxidase, is added and they can cross-link to the substrate once activated by the carbodiimide.	Carbodiimides	207-219	LOC104968582	Bos taurus	99-111
7153522-1	1982	The efficiency of conjugation of mycotoxin derivatives containing a carboxylic group or other related functional groups to bovine serum albumin (BSA) by water soluble carbodiimide method, mixed anhydride method and reductive alkylation technique, improved considerably when a modified BSA was used in which the carboxylic groups in the protein were blocked by ethylenediamine (EDA).	Carbodiimides	167-179	albumin	Oryctolagus cuniculus	130-143
6959823-0	1982	The interaction of acetylcholinesterase with carbodiimides.	Carbodiimides	45-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-39
6291584-0	1982	Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide.	Carbodiimides	86-98	cytochrome c, somatic	Homo sapiens	0-12
6291584-0	1982	Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide.	Carbodiimides	86-98	cytochrome c, somatic	Homo sapiens	46-58
6291584-4	1982	This new species was the major site of radiolabeling when cytochrome c oxidase was treated with [14C]CH3EDC, indicating covalent incorporation of the carbodiimide.	Carbodiimides	150-162	cytochrome c, somatic	Homo sapiens	58-70
6291584-5	1982	Equimolar concentrations of cytochrome c dramatically protected cytochrome c oxidase from inhibition by the carbodiimide and in approximately the same proportion shielded subunit II from modification to the labeled II" species.	Carbodiimides	108-120	cytochrome c, somatic	Homo sapiens	28-40
7138504-1	1982	Treatment of human immunoglobulin G, albumin and fibronectin with water-soluble carbodi-imide at pH4.75 in the presence of glycine ethyl ester resulted in an avid binding of (125)I-labelled native fibrinectin to the modified proteins.	Carbodiimides	80-93	fibronectin 1	Homo sapiens	49-60
7138504-3	1982	In affinity chromatography under physiological conditions, serum was depleted of fibronectin when run through columns of the carbodi-imide-treated proteins coupled to agarose.	Carbodiimides	125-138	fibronectin 1	Homo sapiens	81-92
7138504-5	1982	The binding of radiolabelled fibronectin to the carbodi-imide-treated proteins was inhibited by unlabelled fibronectin in relatively low concentrations, but also by albumin in higher concentrations.	Carbodiimides	48-61	fibronectin 1	Homo sapiens	29-40
7138504-5	1982	The binding of radiolabelled fibronectin to the carbodi-imide-treated proteins was inhibited by unlabelled fibronectin in relatively low concentrations, but also by albumin in higher concentrations.	Carbodiimides	48-61	fibronectin 1	Homo sapiens	107-118
6281255-6	1982	In a first attempt to test this model, carboxyl groups of cytochrome c peroxidase have been modified with a water-soluble carbodiimide, either alone or in combination with a nucleophile.	Carbodiimides	122-134	cytochrome c, somatic	Homo sapiens	58-70
6281255-10	1982	In the presence of the carbodiimide, cytochrome c and peroxidase were cross-linked to form a covalent 1:1 complex and the linkage sites were preliminarily characterized.	Carbodiimides	23-35	cytochrome c, somatic	Homo sapiens	37-49
6212060-0	1982	Cardiac myosin subfragment 1 modification by carbodiimide in the presence of a nucleophile.	Carbodiimides	45-57	myosin heavy chain 14	Homo sapiens	8-14
6952210-1	1982	Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits.	Carbodiimides	127-139	complement C1q A chain	Homo sapiens	173-176
6114435-1	1981	The topography of the rigor complex between F-actin and myosin heads (S1) has been investigated by carbodiimide zero-length cross-linking.	Carbodiimides	99-111	myosin heavy chain 14	Homo sapiens	56-62
6270851-2	1981	Cortisol-21-hemisuccinate was conjugated with beta-galactosidase using a water-soluble carbodiimide.	Carbodiimides	87-99	galactosidase beta 1	Bos taurus	46-64
7462218-3	1981	Chemical modification of the four carboxyl groups of the nonpolar peptide of cytochrome b5 with carbodiimide and methylamine to produce a derivative with no anionic charged residues also resulted in a loss of this type of stable membrane interaction.	Carbodiimides	96-108	cytochrome b5 type A	Homo sapiens	77-90
6114744-0	1981	Modification of myosin subfragment 1 by carbodiimide in the presence of a nucleophile.	Carbodiimides	40-52	myosin heavy chain 14	Homo sapiens	16-22
7202411-2	1981	Carboxylase groups in bovine pancreatic phospholipase A2 were modified using a water-soluble carbodiimide and semicarbazide.	Carbodiimides	93-105	LOC104974671	Bos taurus	40-56
7317155-1	1981	To work out methods of synthesis of stabilized enzymatic preparations for clinical application, subunit enzyme glyceraldehyde-3-phosphatedehydrogenase was treated with bifunctional reagents--aliphatic diacids, activated by water-soluble carbodiimide.	Carbodiimides	237-249	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-150
6787001-0	1981	The use of a carbodiimide-containing fixative for the immunohistochemical demonstration of coagulation factor VIII in rat vascular tissue.	Carbodiimides	13-25	coagulation factor VIII	Rattus norvegicus	91-114
6444384-0	1980	The proteolipid of a mutant ATPase from Escherichia coli defective in H+-conduction contains a glycine instead of the carbodiimide-reactive aspartyl residue.	Carbodiimides	118-130	ATPase	Escherichia coli	28-34
6928607-4	1980	The results demonstrate that the major histone H1-core histone dimer generated upon carbodiimide crosslinking of intact nuclei, chromatin, or mononucleosomes consists of the segment of histone H1 containing amino acids 74-106 crosslinked to the segment of histone H2A containing amino acids 58-129.	Carbodiimides	84-96	LOC100299831	Bos taurus	256-267
518912-4	1979	Fibronectin remained functionally intact after partial or complete reduction and alkylation, oxidation of 59% of the carbohydrates with sodium periodate, citraconylation, carbodiimide-catalyzed amide formation, and oxidation of 35.2 residues of tryptophan/molecule with N-bromosuccinimide.	Carbodiimides	171-183	fibronectin 1	Homo sapiens	0-11
546446-2	1979	Modification of pancreatic trypsin inhibitor by carboxymethyl dextran with the aid of carboxyl groups of the carrier activated by water-soluble carbodiimide has been carried out.	Carbodiimides	144-156	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	27-44
287057-1	1979	Water-soluble carbodiimide crosslinks histones 1A and 1B to histone 2A and to semi-histone A24 in chromatin from mouse cells.	Carbodiimides	14-26	CD164 antigen	Mus musculus	91-94
35543-4	1979	Binding of human serum albumin was reduced when two chemical coupling agents, glutaraldehyde and carbodiimide were included in the human serum albumin solution, the elution of adsorbed HSA from the resins under severe flow conditions was reduced, and the amount eluted was minimal in all instances.	Carbodiimides	97-109	albumin	Homo sapiens	17-30
35543-4	1979	Binding of human serum albumin was reduced when two chemical coupling agents, glutaraldehyde and carbodiimide were included in the human serum albumin solution, the elution of adsorbed HSA from the resins under severe flow conditions was reduced, and the amount eluted was minimal in all instances.	Carbodiimides	97-109	albumin	Homo sapiens	137-150
153770-0	1978	[Inhibition of mitochondrial ATPase by water-soluble carbodiimide].	Carbodiimides	53-65	ATP synthase F1 subunit epsilon	Homo sapiens	15-35
479609-0	1979	Binding of ovalbumin to mouse spleen cells with and without carbodiimide.	Carbodiimides	60-72	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	11-20
479609-2	1979	In the presence or absence of carbodiimide (ECDI), uptake increased with greater cell numbers, increasing OVA concentration and increasing time up to 60 min.	Carbodiimides	30-42	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	106-109
351326-0	1978	Carbohydrate antigens: coupling melibionic acid to bovine serum albumin using water-soluble carbodiimide.	Carbodiimides	92-104	albumin	Homo sapiens	58-71
654384-1	1978	Gastrin antisera were raised by immunization of rabbits or guinea pigs with synthetic human gastrin I conjugated to bovine serum albumin by carbodiimide.	Carbodiimides	140-152	gastrin	Oryctolagus cuniculus	0-7
859025-0	1977	Radioactive labeling of protein carboxyl groups on factor VIII: use of carbodiimides for nuclear medicine.	Carbodiimides	71-84	cytochrome c oxidase subunit 8A	Homo sapiens	58-62
14830-8	1977	Protection against inactivation of the enzyme by carbodiimide was provided also by the presence of alkali and alkaline earth metal ions, which are non-essential activators of sucrase-isomaltase.	Carbodiimides	49-61	sucrase-isomaltase, intestinal	Oryctolagus cuniculus	175-193
14830-13	1977	A possible role for the carbodiimide-reactive carboxyl groups at the active centers of sucrase-isomaltase is discussed.	Carbodiimides	24-36	sucrase-isomaltase, intestinal	Oryctolagus cuniculus	87-105
557070-3	1977	The indirect derivative, insulin carboxyhexyl sepharose, was prepared in two ways: by a carbodiimide procedure and by an N-hydroxysuccinimide ester method.	Carbodiimides	88-100	insulin	Homo sapiens	25-32
194233-2	1977	To overcome this problem we have extended peptides at the carboxy terminus by attachment to equine cytochrome c by a water soluble carbodiimide, relying on the acetylated N-terminus of the cytochrome to minimize its direct contribution to recovery of PTH-amino acids.	Carbodiimides	131-143	cytochrome c, somatic	Equus caballus	99-111
822668-2	1976	Antibodies were successfully produced following the coupling of synthetic arginine vasopressin with bovine serum albumin carried out with carbodiimide.	Carbodiimides	138-150	arginine vasopressin	Homo sapiens	83-94
134890-4	1976	The activity of this ATPase is inhibited in vitro by various carbodiimides, phloridzin and sodium azide.	Carbodiimides	61-74	dynein axonemal heavy chain 8	Homo sapiens	21-27
1064879-1	1976	A peptide corresponding to the 11 amino acid residues of the NH2-terminal portion in the sequence of carcinoembryonic antigen(CNTHETIC CEA(1-11) peptide was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL-alanine( as well as to bovine serum albumin.	Carbodiimides	194-206	CEA cell adhesion molecule 3	Homo sapiens	135-138
1269623-0	1976	Host immune rejection of TA3 ascites carcinoma cells following administration of a water soluble carbodiimide.	Carbodiimides	97-109	RIKEN cDNA 2700049A03 gene	Mus musculus	25-28
1251575-3	1976	By carbodiimide treatment of human erythrocyte glycoproteins, which causes intramolecular coupling of N-acetylneuraminic acid carboxyl groups and nucleophilic centers of the glycoprotein backbone, Pr3 antigen activity is strongly increased, while Pr1 and Pr2 determinants are inactivated.	Carbodiimides	3-15	proteinase 3	Homo sapiens	197-200
1251575-3	1976	By carbodiimide treatment of human erythrocyte glycoproteins, which causes intramolecular coupling of N-acetylneuraminic acid carboxyl groups and nucleophilic centers of the glycoprotein backbone, Pr3 antigen activity is strongly increased, while Pr1 and Pr2 determinants are inactivated.	Carbodiimides	3-15	transmembrane protein 37	Homo sapiens	247-250
4435733-0	1974	Coupling of glutamine by the carbodiimide method in the solid-phase synthesis of two C-terminal peptides of secretin.	Carbodiimides	29-41	secretin	Homo sapiens	108-116
11947105-0	1973	A spin-label carbodiimide as a probe for mitochondrial ATPase.	Carbodiimides	13-25	ATP synthase F1 subunit epsilon	Homo sapiens	41-61
1141804-1	1975	Thyroxine (T-4) and tri-iodothyronine (T-3) were coupled to human serum albumin (HSA) with carbodi-imide.	Carbodiimides	91-104	albumin	Oryctolagus cuniculus	66-79
11946256-0	1968	- No Title - The blockage of the carboxyl groups of a pancreatic trypsin inhibitor (inhibitor of Kunitz) has been performed with a water-soluble carbodiimide and glycine ethyl ester.	Carbodiimides	145-157	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	65-103
11946659-0	1972	Spin-exchange interaction in polyuridilyc acid modified with a spin-labelled carbodiimide.	Carbodiimides	77-89	spindlin 1	Homo sapiens	0-4
11946659-0	1972	Spin-exchange interaction in polyuridilyc acid modified with a spin-labelled carbodiimide.	Carbodiimides	77-89	spindlin 1	Homo sapiens	63-67
18668825-1	1971	The endocrine polypeptide (APUD) cells responsible for the production and storage of secretin have been demonstrated, in canine duodenum, by the application of an indirect immunofluorescence technique, using anti-pure porcine secretin, to carbodiimide-fixed cryostat sections.	Carbodiimides	239-251	SCT	Canis lupus familiaris	85-93
33740318-0	2021	B-B- vs. B-H-Bond Activation in a (mu-Hydrido)diborane(4) Anion upon Cycloaddition with CO2, Isocyanates, or Carbodiimides.	Carbodiimides	109-122	bleomycin hydrolase	Homo sapiens	9-12
33389237-3	2021	Then, GOD and monoclonal anti-CRP antibody with a high molar ratio were covalently conjugated onto carboxylated dendrimers via typical carbodiimide coupling.	Carbodiimides	135-147	C-reactive protein	Homo sapiens	30-33
33579470-3	2021	The liposomes prepared by thin film hydration technique were later conjugated with VEGF antibody on liposomal surface by standard carbodiimide chemistry and using DSPE-PEG-COOH as linker.	Carbodiimides	130-142	vascular endothelial growth factor A	Homo sapiens	83-87
32536398-5	2020	The carbodiimide coupling in dimethyl sulfoxide was effective to introduce the highest amounts of beta-CD (0.17 mmol/g sample) to the CNC in this study.	Carbodiimides	4-16	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	98-105
32979454-9	2020	FGF2 was conjugated to superparamagnetic iron-oxide nanoparticles (SPIONs) using carbodiimide chemistry, and the resulting FGF2-SPIONs were confirmed by dynamic light scattering (DLS), zeta potential, dot-blot analysis and Prussian Blue iron-staining.	Carbodiimides	81-93	fibroblast growth factor 2	Homo sapiens	0-4
32667728-1	2020	Rhodium PC carbene P complexes 1-L {L = PPh 3 , PPh 2 (C 6 F 5 )} react with iso -thiocyanate, carbodiimide and disulphide to enable C-S, C-N and S-S bond cleavage.	Carbodiimides	95-107	protein phosphatase 4 catalytic subunit	Homo sapiens	40-45
32334289-4	2020	Carbodiimide-assisted zwitterionic modification was verified by ATR-IR and XPS analyses and was found to not affect membrane pore size but significantly enhance membrane"s permeation and anti-dye-deposition performances.	Carbodiimides	0-12	ATR serine/threonine kinase	Homo sapiens	64-67
32930214-3	2020	Thereafter, rabbit polyclonal antibodies to cTnI were covalently conjugated to the bis-MPA-COOH dendrimers through typical carbodiimide coupling.	Carbodiimides	123-135	troponin I3, cardiac type	Homo sapiens	44-48
32436550-4	2020	When compared to conventional carbodiimide chemistry, this conjugation approach leads to the generation of nanoparticles with a higher surface loading of cetuximab F(ab) and with markedly improved ability to bind to the target epidermal growth factor receptor.	Carbodiimides	30-42	epidermal growth factor receptor	Homo sapiens	227-259
32043888-4	2020	Removal of the Boc and allyl protecting groups, followed by carbodiimide-mediated cyclization, led to the 13-membered ring with the aminovinylcysteine moiety embedded.	Carbodiimides	60-72	BOC cell adhesion associated, oncogene regulated	Homo sapiens	15-18
32125865-3	2020	Carbon dots were synthesized by the hydrothermal method and, subsequently, conjugated with VEGF using carbodiimide coupling.	Carbodiimides	102-114	vascular endothelial growth factor A	Homo sapiens	91-95
32003557-7	2020	In-channel immobilization of glucose oxidase (GOx) at the DLC surface was realized through carbodiimide covalent linkages.	Carbodiimides	91-103	hydroxyacid oxidase 1	Homo sapiens	29-44
32003557-7	2020	In-channel immobilization of glucose oxidase (GOx) at the DLC surface was realized through carbodiimide covalent linkages.	Carbodiimides	91-103	hydroxyacid oxidase 1	Homo sapiens	46-49
31689595-2	2020	These nanomaterials were sequentially deposited on to the screen-printed carbon electrode (SPCE) and antibodies against ALP (anti-ALP) were immobilized using carbodiimide bioconjugation process.	Carbodiimides	158-170	alkaline phosphatase, placental	Homo sapiens	120-123
31821805-4	2020	The aim of this project was twofold: to chemically modify l-asparaginase with carboxymethyl dextran via carbodiimide cross linker, and to evaluate and compare the biochemical and structural properties of the native and modified enzymes.	Carbodiimides	104-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	58-72
31689595-2	2020	These nanomaterials were sequentially deposited on to the screen-printed carbon electrode (SPCE) and antibodies against ALP (anti-ALP) were immobilized using carbodiimide bioconjugation process.	Carbodiimides	158-170	alkaline phosphatase, placental	Homo sapiens	130-133
31673811-2	2019	The polyclonal CRP-antibody-conjugated fullerene NPs were simply prepared by 1-ethyl-3-(3-dimethyllaminopropyl)-carbodiimide hydrochloride coupling after carboxylation of fluorescent fullerene NPs.	Carbodiimides	77-138	C-reactive protein	Homo sapiens	15-18
31758063-5	2019	The carbodiimide conjugation between the N-H group of cTnI and the functionalized COOH group on GQDs enabled the detection of cTnI biomarker.	Carbodiimides	4-16	troponin I3, cardiac type	Homo sapiens	54-58
31758063-5	2019	The carbodiimide conjugation between the N-H group of cTnI and the functionalized COOH group on GQDs enabled the detection of cTnI biomarker.	Carbodiimides	4-16	troponin I3, cardiac type	Homo sapiens	126-130
31647224-1	2019	The formation of the new compound Sn9O5Cl4(CN2)2 is reported and placed in the context of several other recently discovered tin carbodiimide compounds (Sn(CN2), Sn2O(CN2), and Sn4Cl2(CN2)3), all of which contain divalent tin.	Carbodiimides	124-140	carnosine dipeptidase 2	Homo sapiens	43-46
31357373-9	2019	Then, the surface was further modified and functionalized by binding notch-4 receptor antibody using carbodiimide.	Carbodiimides	101-113	notch receptor 4	Homo sapiens	69-76
31632027-4	2019	The submicron-flower-shaped nanocomposites were further functionalized with ginsenoside Rh2 by a cleavable ester bond via carbodiimide chemistry to form Rh2HAZnO.	Carbodiimides	122-134	Rh associated glycoprotein	Homo sapiens	88-91
31218479-8	2019	The isotropic and anisotropic polarizabilities of carbodiimide have been calculated from relevant tensor components for both reaction mechanisms with the help of data obtained by DFT/B3LYP and MP2 methods using aug-cc-pVTZ basis sets in gaseous phase as well as in PCM.	Carbodiimides	50-62	tryptase pseudogene 1	Homo sapiens	193-196
31176112-5	2019	GNS were coupled with uPAR-Ab via carbodiimide activation chemistry with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) as a heterobifunctional crosslinker.	Carbodiimides	34-46	plasminogen activator, urokinase receptor	Homo sapiens	22-26
31257386-0	2019	Synthesis and characterization of 2-t-butylimino-functionalized indolyl rare-earth metal amido complexes for the catalytic addition of terminal alkynes to carbodiimides: the dimeric complexes with the alkynide species in the mu-eta1:eta2 bonding modes.	Carbodiimides	155-168	DNA polymerase iota	Homo sapiens	233-237
30264501-4	2018	Further, anti-EGFR antibody (Cetuximab, C225) was covalently linked to the Cys-AuNP by carbodiimide-mediated amidation protocol to yield the C225-AuNP immunoprobe.	Carbodiimides	87-99	epidermal growth factor receptor	Homo sapiens	14-18
30941391-2	2019	Direct synthesis of magnesium amidinates of the general formula [RNC(R1)NR]MgR2 has been performed from appropriate carbodimide and Grignard reagents (R = iPr, Cy, pTol; R1 = Me, nBu; R2 = nBu, Cl, I).	Carbodiimides	116-127	MGR2	Homo sapiens	75-79
30385376-3	2019	The chemokine SDF-1, a specific antibody, was conjugated to NPs by the carbodiimide method.	Carbodiimides	71-83	C-X-C motif chemokine ligand 12	Homo sapiens	14-19
29658365-3	2018	The active NP cell-targeting biomarker CDH2 antibody (AbCDH2) was further conjugated to the NBs using a carbodiimide method.	Carbodiimides	104-116	cadherin-2	Oryctolagus cuniculus	39-43
30124284-3	2018	Here, we report the use of mass spectrometry-based, carbodiimide-mediated protein carboxyl group (aspartic and glutamic acid) footprinting to map solvent accessible amino acids of the ectodomain of FER (ectoFER), including those involved in RALF1 binding and/or allosteric changes.	Carbodiimides	52-64	rapid alkalinization factor 1	Arabidopsis thaliana	241-246
29555471-4	2018	After these steps, a monoclonal antibody (YPSMA-1) to prostate-specific membrane antigen (PSMA) was conjugated with carboxyl-modified Gd@SiO2 (Gd@SiO2-COOH) nanoparticles (NPs) by the carbodiimide method.	Carbodiimides	184-196	folate hydrolase 1	Homo sapiens	54-88
29555471-4	2018	After these steps, a monoclonal antibody (YPSMA-1) to prostate-specific membrane antigen (PSMA) was conjugated with carboxyl-modified Gd@SiO2 (Gd@SiO2-COOH) nanoparticles (NPs) by the carbodiimide method.	Carbodiimides	184-196	folate hydrolase 1	Homo sapiens	43-47
29687337-8	2018	Graphical abstract Monodisperse magnetic poly(glycidyl methacrylate) microspheres were synthesized, conjugated with 46 kDa form of unconventional Myo1C protein (p46/Myo1C) via carbodiimide (DIC) chemistry, and specific autoantibodies isolated from blood of multiple sclerosis (MS) patients; immunoglobulin M (IgM) level increased in MS patients.	Carbodiimides	176-188	myosin IC	Homo sapiens	146-151
29687337-8	2018	Graphical abstract Monodisperse magnetic poly(glycidyl methacrylate) microspheres were synthesized, conjugated with 46 kDa form of unconventional Myo1C protein (p46/Myo1C) via carbodiimide (DIC) chemistry, and specific autoantibodies isolated from blood of multiple sclerosis (MS) patients; immunoglobulin M (IgM) level increased in MS patients.	Carbodiimides	176-188	myosin IC	Homo sapiens	165-170
29141539-3	2018	MATERIALS AND METHODS: Monophosphate analogs of fludarabine, gemcitabine, and dexamethasone were combined with a carbodiimide reagent in the presence of imidazole to produce reactive intermediates that were subsequently covalently bound to monoclonal anti-IGF-1R or anti-EGFR IgG-immunoglobulin.	Carbodiimides	113-125	insulin like growth factor 1 receptor	Homo sapiens	256-262
29141539-3	2018	MATERIALS AND METHODS: Monophosphate analogs of fludarabine, gemcitabine, and dexamethasone were combined with a carbodiimide reagent in the presence of imidazole to produce reactive intermediates that were subsequently covalently bound to monoclonal anti-IGF-1R or anti-EGFR IgG-immunoglobulin.	Carbodiimides	113-125	epidermal growth factor receptor	Homo sapiens	271-275
28872298-7	2017	The selectivity of the SPME method toward mRNA was enhanced by functionalizing the PA sorbent with oligo dT20 using carbodiimide-based amide linker chemistry.	Carbodiimides	116-128	thioredoxin peroxidase 1	Drosophila melanogaster	105-109
30920532-8	2017	Furthermore, VEGF-loading and release were dependent on the carbodiimide concentration and loading conditions for both biopolymers.	Carbodiimides	60-72	vascular endothelial growth factor A	Homo sapiens	13-17
28671603-5	2017	Silver nanoparticles capped with a carboxylated PVP were produced and further covalently conjugated with IL-10 protein by carbodiimide crosslinker chemistry.	Carbodiimides	122-134	interleukin 10	Homo sapiens	105-110
29019478-2	2017	Highly swellable, dual-responsive bovine serum albumin (BSA)-based injectable hydrogels are prepared here by the chemical conjugation of pH- and temperature-responsive oligo(sulfamethazine acrylate-co-N-isopropylacrylamide) (oligo(SMA-co-NIPAM)) copolymers on the surface of BSA through carbodiimide-mediated chemistry.	Carbodiimides	287-299	albumin	Rattus norvegicus	41-54
28667386-6	2017	Then, tubulin (TUB), as a receptor, was covalently immobilized at the AuNPs/GCE surface via carbodiimide coupling reaction using N-(3 dimethylaminopropyl)-N"-ethyl carbodiimide (EDC) and N-hydroxy succinimide (NHS).	Carbodiimides	92-104	TUB bipartite transcription factor	Homo sapiens	6-13
28667386-6	2017	Then, tubulin (TUB), as a receptor, was covalently immobilized at the AuNPs/GCE surface via carbodiimide coupling reaction using N-(3 dimethylaminopropyl)-N"-ethyl carbodiimide (EDC) and N-hydroxy succinimide (NHS).	Carbodiimides	92-104	TUB bipartite transcription factor	Homo sapiens	15-18
28837060-3	2017	Different concentrations of active tPA were immobilized on carboxylated nanoparticles through carbodiimide-mediated amide bond formation.	Carbodiimides	94-106	chromosome 20 open reading frame 181	Homo sapiens	35-38
28766623-3	2017	Addition of methanol to the compounds derived from addition of Ph2PBpin to carbodiimides, isocyanates, and isothiocyanates resulted in traditional hydrophosphination products.	Carbodiimides	75-88	polyhomeotic homolog 2	Homo sapiens	63-66
28351640-3	2017	To decrease the background signal, monoclonal anti-human PSA capture antibody was covalently conjugated onto an activated glassy carbon electrode via typical carbodiimide coupling.	Carbodiimides	158-170	kallikrein related peptidase 3	Homo sapiens	57-60
28218731-8	2017	A carbodiimide conjugation approach using N-(3-dimethylaminopropyl)-N"-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) cross-linked anti-T-Tau to the carboxylic groups on one end of the MPA.	Carbodiimides	2-14	microtubule associated protein tau	Homo sapiens	160-163
28240872-4	2017	After preparation of PCDH/PCDH-COOH (9/1, m/m) mixed micelles, Annexin V was coupled with the micelles using carbodiimide chemistry.	Carbodiimides	109-121	annexin A5	Homo sapiens	63-72
27561602-3	2017	The covalent immunopharmaceutical, gemcitabine-(5"-phosphoramidate)-[anti-IGF-1R] was synthesized by reacting gemcitabine with a carbodiimide reagent to form a gemcitabine carbodiimide phosphate ester intermediate which was subsequently reacted with imidazole to create amine-reactive gemcitabine-(5"-phosphorylimidazolide) intermediate.	Carbodiimides	129-141	insulin like growth factor 1 receptor	Homo sapiens	74-80
27287127-1	2016	The aim of this study was to develop multi-walled carbon nanotubes (MWCNT) which were covalently conjugated with transferrin by carbodiimide chemistry and loaded with docetaxel as a model drug for effective treatment of lung cancer in comparison with the commercial docetaxel injection (Docel ).	Carbodiimides	128-140	transferrin	Homo sapiens	113-124
27612703-3	2016	To this end, ALP is covalently immobilized by carbodiimide-mediated chemoligation on two highly bioinert ceramics, alpha-alumina (Al2O3) and yttria-stabilized zirconia (Y-TZP) that are well-established for load-bearing applications.	Carbodiimides	46-58	alkaline phosphatase, placental	Homo sapiens	13-16
27574398-3	2016	MATERIALS AND METHODS: The covalent immunopharmaceutical, dexamethasone-(C21-phosphoramide)-[anti-EGFR] was synthesized by reacting dexamethasone-21-monophosphate with a carbodiimide reagent to form a dexamethasone phosphate carbodiimide ester that was subsequently reacted with imidazole to create an amine-reactive dexamethasone-(C21-phosphorylimidazolide) intermediate.	Carbodiimides	170-182	epidermal growth factor receptor	Homo sapiens	98-102
27122297-2	2016	This study was designed to compare the properties of collagen-chitosan porous scaffolds cross-linked with gamma-irradiation and carbodiimide (CAR) for the first time.	Carbodiimides	128-140	CXADR pseudogene 1	Homo sapiens	142-145
26748366-2	2016	The anti-cTnI was covalently conjugated to afGQDs through carbodiimide coupling reaction.	Carbodiimides	58-70	troponin I3, cardiac type	Homo sapiens	9-13
26177854-1	2016	The purpose of the study was to test a novel treatment that carbodiimide-derivatized-hyaluronic acid-lubricin (cd-HA-lubricin) combined cell-based therapy in an immobilized flexor tendon repair in a canine model.	Carbodiimides	60-72	proteoglycan 4	Canis lupus familiaris	101-109
26877175-2	2016	The CYP2C9 was attached to magnetic SiMAG-carboxyl microparticles using the carbodiimide method.	Carbodiimides	76-88	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	4-10
26686901-1	2016	Azide-methylenecyclopropanes (azide-MCPs) underwent an intermolecular cyclization with isonitriles catalyzed by a Rh(II) complex to produce a series of pyrrolo[2,3-b]quinolines in moderate to good yields via carbodiimide intermediates.	Carbodiimides	208-220	Rh blood group D antigen	Homo sapiens	114-120
26177854-1	2016	The purpose of the study was to test a novel treatment that carbodiimide-derivatized-hyaluronic acid-lubricin (cd-HA-lubricin) combined cell-based therapy in an immobilized flexor tendon repair in a canine model.	Carbodiimides	60-72	proteoglycan 4	Canis lupus familiaris	117-125
26433365-4	2015	S-S and Se-Se were immobilized on the PDAM/HD surface via carbodiimide coupling chemistry.	Carbodiimides	58-70	TP73 antisense RNA 1	Homo sapiens	38-42
26013660-0	2015	Synthesis and Mechanistic Study of Cyclic Oxoguanidines via Zn(OTf)2 -Catalyzed Guanylation/Amidation from Readily Available Amino Acid Esters and Carbodiimides.	Carbodiimides	147-160	POU class 2 homeobox 2	Homo sapiens	63-68
26264645-2	2015	In the present study, elastin-like recombinamers hydrogels were produced by means of carbodiimide-catalyzed crosslinking with citric acid, a molecule suggested to be essential for bone nanostructure.	Carbodiimides	85-97	elastin	Homo sapiens	22-29
27097407-6	2015	Here, the conjugates of luteoloside-bovine (LG-BSA) and luteoloside-ovalbumin (LG-OVA) were produced as the immunogen and coating antigen by the carbodiimide ( CDI) method, respectively.	Carbodiimides	145-157	ovalbumin	Bos taurus	68-77
26013660-1	2015	The Zn(OTf)2 -catalyzed guanylation/amidation from readily available amino acid esters and carbodiimides is achieved to provide efficiently various cyclic oxoguanidines, including 2-amino-1H-imidazol-5(4H)-ones and 2-aminoquinazolin-4(3H)-ones in medium-to-high yields.	Carbodiimides	91-104	POU class 2 homeobox 2	Homo sapiens	7-12
25988279-4	2015	PA was coupled to SLN via amide linkage using carbodiimide chemistry and coupling was confirmed by comparative infrared spectroscopic analysis.	Carbodiimides	46-58	sarcolipin	Homo sapiens	18-21
25943251-6	2015	Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry.	Carbodiimides	307-319	interferon gamma	Homo sapiens	13-29
26157796-13	2015	A maximum of MMP3 was observed in the CDI group at day 30.	Carbodiimides	38-41	matrix metallopeptidase 3	Rattus norvegicus	13-17
25943251-6	2015	Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry.	Carbodiimides	307-319	interferon gamma	Homo sapiens	31-39
25283448-7	2015	There was a 10 fold increase on the dynamic range of the detection of NS1 comparing copper free click coupling to carbodiimide coupling, one of the most common approaches for nanoparticle functionalization.	Carbodiimides	114-126	influenza virus NS1A binding protein	Homo sapiens	70-73
25046001-1	2014	Several key properties of catalase such as thermal stability, resistance to protease degradation, and resistance to ascorbate inhibition were improved, while retaining its structure and activity, by conjugation to poly(acrylic acid) (PAA, Mw 8000) via carbodiimide chemistry where the amine groups on the protein are appended to the carboxyl groups of the polymer.	Carbodiimides	252-264	catalase	Homo sapiens	26-34
25826468-0	2015	Synthesis of carbodiimides by I2/CHP-mediated cross-coupling reaction of isocyanides with amines under metal-free conditions.	Carbodiimides	13-26	ras homolog family member V	Homo sapiens	33-36
25826468-1	2015	An I2/CHP-mediated cross-coupling reaction of isocyanides with readily accessible amines via C-N formation is described for carbodiimide synthesis in moderate to excellent yields.	Carbodiimides	124-136	ras homolog family member V	Homo sapiens	6-9
25785370-5	2015	The developed synthetic carbon nanotube/bispecific tandem antibody conjugates (denoted as SNAs) show an effective binding affinity against HER2 that is three orders of magnitude higher than that of the carbon nanotubes bearing a randomly conjugated tandem antibody prepared by carbodiimide chemistry.	Carbodiimides	277-289	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
25462843-2	2015	The mineralizing enzyme alkaline phosphatase (ALP) is covalently immobilized by a carbodiimide-mediated chemoligation method.	Carbodiimides	82-94	alkaline phosphatase, placental	Homo sapiens	24-44
25462843-2	2015	The mineralizing enzyme alkaline phosphatase (ALP) is covalently immobilized by a carbodiimide-mediated chemoligation method.	Carbodiimides	82-94	alkaline phosphatase, placental	Homo sapiens	46-49
26613088-4	2015	MATERIALS AND METHODS: The fludarabine-(C2- methylhydroxyphosphoramide)-[anti-IGF-1R] was synthesized by initially reacting fludarabine with a carbodiimide to form a fludarabine carbodiimide phosphate ester intermediate that was subsequently reacted with imidazole to create an amine-reactive fludarabine- (C2-phosphorylimidazolide) intermediate.	Carbodiimides	143-155	insulin like growth factor 1 receptor	Homo sapiens	78-84
24497431-4	2014	Results demonstrated that a resilient, hydrophilic hydrogel which displays a unique "shape-memory" sponge characteristic could be formed from a blend of soluble elastin aggregates, chondroitin-6-sulfate, hyaluronic acid and collagen following freeze-drying, stabilization with a carbodiimide and penta-galloyl glucose-based fixative, and subsequent partial degradation with glycosaminoglycan degrading enzymes.	Carbodiimides	279-291	elastin	Homo sapiens	161-168
25133390-3	2014	To address this issue, we synthesized a new nano-carrier system comprising of cholic acid-polyethylenimine (CA-PEI) copolymer micelles, via carbodiimide-mediated coupling for the efficient delivery of small interfering ribonucleic acid (siRNA) and bovine serum albumin (BSA) as model protein.	Carbodiimides	140-152	albumin	Homo sapiens	255-268
24657702-5	2014	METHODS: Recombinant human vimentin was conjugated to MagPlex  beads using standard carbodiimide/NHS chemistry and coupling efficiency tested and assay parameters determined using a commercial anti-vimentin polyclonal antibody.	Carbodiimides	84-96	vimentin	Homo sapiens	27-35
24859437-4	2014	These nanoparticles were further surface decorated with antibodies against Human Epithelial Receptor-2 (HER-2) using carbodiimide chemistry.	Carbodiimides	117-129	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-109
24445876-7	2014	RESULTS: Allograft tendons treated with carbodiimide-derivatized hyaluronic acid-lubricin had decreased adhesions at the proximal tendon/graft repair and within the flexor sheath, improved digit function, and increased graft gliding ability.	Carbodiimides	40-52	proteoglycan 4	Canis lupus familiaris	81-89
24445876-10	2014	CONCLUSIONS: Carbodiimide-derivatized hyaluronic acid-lubricin treatment of tendon allograft improves digit functional outcomes after flexor tendon reconstruction.	Carbodiimides	13-25	proteoglycan 4	Canis lupus familiaris	54-62
24790428-6	2014	The surface of NPs was further decorated with solubilizing agent polyethylene glycol (PEG) and tumor endothelial marker 1 (TEM1)/endosialin-targeting antibody (Ab) through carbodiimide/N-hydroxysuccinimide chemistry.	Carbodiimides	172-184	CD248 molecule	Homo sapiens	95-121
24790428-6	2014	The surface of NPs was further decorated with solubilizing agent polyethylene glycol (PEG) and tumor endothelial marker 1 (TEM1)/endosialin-targeting antibody (Ab) through carbodiimide/N-hydroxysuccinimide chemistry.	Carbodiimides	172-184	CD248 molecule	Homo sapiens	123-127
24790428-6	2014	The surface of NPs was further decorated with solubilizing agent polyethylene glycol (PEG) and tumor endothelial marker 1 (TEM1)/endosialin-targeting antibody (Ab) through carbodiimide/N-hydroxysuccinimide chemistry.	Carbodiimides	172-184	CD248 molecule	Homo sapiens	129-139
24334409-0	2014	Carbodiimide inactivation of MMPs and effect on dentin bonding.	Carbodiimides	0-12	matrix metallopeptidase 2	Homo sapiens	29-33
32261331-3	2013	To enable the glucose detection, we functionalized the 3-mercaptopropanoic acid (MPA) capped CdTe QDs with glucose oxidase (GOx), the enzyme specific to beta-d-glucose, using carbodiimide chemistry.	Carbodiimides	175-187	hydroxyacid oxidase 1	Homo sapiens	107-122
23786610-3	2014	Therefore, this study aimed to evaluate the inactivation of matrix-bound MMPs by two different cross-linking agents, carbodiimide (EDC) or proanthocyanidin (PA), or the MMP-inhibitor, chlorhexidine (CHX), on acid-etched dentin using a simplified MMP assay method.	Carbodiimides	117-129	matrix metallopeptidase 9	Homo sapiens	73-77
23786610-3	2014	Therefore, this study aimed to evaluate the inactivation of matrix-bound MMPs by two different cross-linking agents, carbodiimide (EDC) or proanthocyanidin (PA), or the MMP-inhibitor, chlorhexidine (CHX), on acid-etched dentin using a simplified MMP assay method.	Carbodiimides	117-129	matrix metallopeptidase 9	Homo sapiens	73-76
32261323-6	2014	Herein, OPH conjugation to the CNTs is carried out by carbodiimide chemistry during the microfiltration process.	Carbodiimides	54-66	acylaminoacyl-peptide hydrolase	Homo sapiens	8-11
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Carbodiimides	164-176	bone morphogenetic protein 2	Mus musculus	18-46
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Carbodiimides	164-176	bone morphogenetic protein 2	Mus musculus	48-53
32261331-3	2013	To enable the glucose detection, we functionalized the 3-mercaptopropanoic acid (MPA) capped CdTe QDs with glucose oxidase (GOx), the enzyme specific to beta-d-glucose, using carbodiimide chemistry.	Carbodiimides	175-187	hydroxyacid oxidase 1	Homo sapiens	124-127
24063264-2	2013	Herein, deferasirox, a high affinity iron chelator, was conjugated to lactoferrin molecules by carbodiimide mediated coupling reaction to create a novel drug delivery system with higher brain permeability through receptor mediated transcytosis.	Carbodiimides	95-107	lactotransferrin	Rattus norvegicus	70-81
23335124-1	2013	We assessed surface coating with carbodiimide derivatized hyaluronic acid combined with lubricin (cd-HA-Lubricin) as a way to improve extrasynovial tendon surface quality and, consequently, the functional results in flexor tendon reconstruction, using a canine in vivo model.	Carbodiimides	33-45	proteoglycan 4	Canis lupus familiaris	104-112
32261106-6	2013	Subsequently, a known mitochondriotropic ligand, triphenylphosphonium (TPP), is conjugated with SAG via a carbodiimide reaction, which is evaluated by NMR and absorption spectra, respectively.	Carbodiimides	106-118	S-antigen visual arrestin	Homo sapiens	96-99
23307958-2	2013	METHODS: GNRs were synthesized and covalently attached to anti-glucose transporter-1 (GLUT-1) antibodies via carbodiimide chemistry.	Carbodiimides	109-121	solute carrier family 2 member 1	Homo sapiens	58-84
23307958-2	2013	METHODS: GNRs were synthesized and covalently attached to anti-glucose transporter-1 (GLUT-1) antibodies via carbodiimide chemistry.	Carbodiimides	109-121	solute carrier family 2 member 1	Homo sapiens	86-92
24124363-5	2013	To synthesize the Gd-PLGA/chitosan (CS)-RGDS particles, carbodiimide-mediated amide bond formation was used to graft the RGDS peptide to CS to form a CS-RGDS film that coated the surface of the PLGA particles.	Carbodiimides	56-68	ral guanine nucleotide dissociation stimulator	Homo sapiens	40-44
24459666-8	2013	BMP2 was immobilized on the treated surfaces via a coupling reaction using carbodiimide.	Carbodiimides	75-87	bone morphogenetic protein 2	Homo sapiens	0-4
24124363-5	2013	To synthesize the Gd-PLGA/chitosan (CS)-RGDS particles, carbodiimide-mediated amide bond formation was used to graft the RGDS peptide to CS to form a CS-RGDS film that coated the surface of the PLGA particles.	Carbodiimides	56-68	ral guanine nucleotide dissociation stimulator	Homo sapiens	121-125
24124363-5	2013	To synthesize the Gd-PLGA/chitosan (CS)-RGDS particles, carbodiimide-mediated amide bond formation was used to graft the RGDS peptide to CS to form a CS-RGDS film that coated the surface of the PLGA particles.	Carbodiimides	56-68	ral guanine nucleotide dissociation stimulator	Homo sapiens	121-125
22767416-5	2013	Antibodies of epithelial cell adhesion molecule (anti-EpCAM) were then immobilized on the albumin-coated magnetic microspheres using the carbodiimide method.	Carbodiimides	137-149	albumin	Homo sapiens	90-97
23565907-2	2013	Bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2) was covalently bonded to chitosan films using carbodiimide chemistry.	Carbodiimides	121-133	bone morphogenetic protein 2	Homo sapiens	0-28
23565907-2	2013	Bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2) was covalently bonded to chitosan films using carbodiimide chemistry.	Carbodiimides	121-133	bone morphogenetic protein 2	Homo sapiens	30-35
23565907-2	2013	Bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2) was covalently bonded to chitosan films using carbodiimide chemistry.	Carbodiimides	121-133	fibroblast growth factor 2	Homo sapiens	40-66
23565907-2	2013	Bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2) was covalently bonded to chitosan films using carbodiimide chemistry.	Carbodiimides	121-133	fibroblast growth factor 2	Homo sapiens	68-73
23012484-4	2012	MATERIAL AND METHODS: The CXCR4 monoclonal antibody and bovine serum albumin (BSA) were bioconjugated with USPIO using carbodiimide.	Carbodiimides	119-131	C-X-C motif chemokine receptor 4	Homo sapiens	26-31
23099427-11	2012	A lower limit of detection (5.6 ng ml(-1)) of BaP was achieved after the activation of the mixture of carbodiimide and succinimide with the alkanethiol SAM on the gold electrode in comparison to that obtained for the unmodified electrode (14.2 ng ml(-1)).	Carbodiimides	102-114	prohibitin 2	Homo sapiens	46-49
23012484-4	2012	MATERIAL AND METHODS: The CXCR4 monoclonal antibody and bovine serum albumin (BSA) were bioconjugated with USPIO using carbodiimide.	Carbodiimides	119-131	albumin	Homo sapiens	63-76
22766469-2	2012	In this strategy, the Au electrode was first modified by consecutive SI-ATRP of ferrocenylmethyl methacrylate (FMMA) and glycidyl methacrylate (GMA), and TNF-alpha antibody was coupled to the copolymer segment of GMA (PGMA) by aqueous carbodiimide coupling reaction.	Carbodiimides	235-247	tumor necrosis factor	Homo sapiens	154-163
22206944-3	2012	The albumin was coupled to DLNE-7 globules (DLNE-8) by water soluble carbodiimide (EDC) method, purified, and quantified by modified Bradford method.	Carbodiimides	69-81	albumin	Rattus norvegicus	4-11
22607555-5	2012	CD7-specific single-chain antibody (scFvCD7) was chemically conjugated to chitosan by carbodiimide chemistry, and nanoparticles were prepared by a complex coacervation method in the presence of siRNA.	Carbodiimides	86-98	CD7 molecule	Homo sapiens	0-3
22421993-2	2012	The MUC1 aptamer was covalently combined with Ru1 (Ru1-aptamer) using aqueous carbodiimide coupling chemistry.	Carbodiimides	78-90	mucin 1, cell surface associated	Homo sapiens	4-8
22607220-6	2012	The functionalized polymer dots were conjugated to streptavidin (SA) by carbodiimide-catalyzed coupling and the Pdot-SA probes effectively and specifically labeled the cancer cell-surface marker Her2 in human breast cancer cells.	Carbodiimides	72-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	195-199
22421993-2	2012	The MUC1 aptamer was covalently combined with Ru1 (Ru1-aptamer) using aqueous carbodiimide coupling chemistry.	Carbodiimides	78-90	Scm like with four mbt domains 1	Homo sapiens	46-49
22421993-2	2012	The MUC1 aptamer was covalently combined with Ru1 (Ru1-aptamer) using aqueous carbodiimide coupling chemistry.	Carbodiimides	78-90	Scm like with four mbt domains 1	Homo sapiens	51-62
23353842-3	2012	METHODS: The chemical cross-linking by soluble carbodiimide (EDC) in combination with the liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) has been employed to characterize the contact surface regions involved in the transient interaction between two catalytic domains of P450 2B4 and cytochrome b5.	Carbodiimides	47-59	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	302-306
22058118-0	2012	Carbodiimide cross-linking inactivates soluble and matrix-bound MMPs, in vitro.	Carbodiimides	0-12	matrix metallopeptidase 9	Homo sapiens	64-68
23353842-3	2012	METHODS: The chemical cross-linking by soluble carbodiimide (EDC) in combination with the liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) has been employed to characterize the contact surface regions involved in the transient interaction between two catalytic domains of P450 2B4 and cytochrome b5.	Carbodiimides	47-59	cytochrome b5 type A	Homo sapiens	315-328
22029414-4	2011	Carbodiimides and isothiocyanate can also insert into the Y-C(alkynyl) sigma bond of 2 to yield complexes (Tp(Me2))CpY[(RN)(2)CC CPh] (R = (i)Pr(7a), Cy(7b)) and (Tp(Me2))CpY[SC(C CPh)NPh] (9).	Carbodiimides	0-13	malic enzyme 2	Homo sapiens	110-113
21944543-1	2012	Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160 ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns.	Carbodiimides	113-125	chorionic gonadotropin subunit beta 5	Homo sapiens	21-50
21944543-1	2012	Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160 ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns.	Carbodiimides	113-125	chorionic gonadotropin subunit beta 5	Homo sapiens	52-55
22029414-4	2011	Carbodiimides and isothiocyanate can also insert into the Y-C(alkynyl) sigma bond of 2 to yield complexes (Tp(Me2))CpY[(RN)(2)CC CPh] (R = (i)Pr(7a), Cy(7b)) and (Tp(Me2))CpY[SC(C CPh)NPh] (9).	Carbodiimides	0-13	malic enzyme 2	Homo sapiens	166-169
22035507-8	2011	Anti-Her2 antibody was then conjugated to superparamagnetic iron oxide nanoparticles using the carbodiimide method.	Carbodiimides	95-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	5-9
21710990-3	2011	By virtue of its poly(ethylene glycol) shell, this polymer naturally forms spherical nanoparticles that minimize nonspecific interaction with biomolecules in aqueous solution, consequently allowing for efficient bioconjugation with anti-HER2 affibody via carbodiimide-activated coupling reaction.	Carbodiimides	255-267	erb-b2 receptor tyrosine kinase 2	Homo sapiens	237-241
21232642-0	2011	Catalase-coupled gold nanoparticles: comparison between the carbodiimide and biotin-streptavidin methods.	Carbodiimides	60-72	catalase	Homo sapiens	0-8
21726466-2	2011	ROS was coupled to keyhole limpt hemocyanin (KLH) and bovine serum albumin (BSA) using carbodiimide reagent.	Carbodiimides	87-99	albumin	Oryctolagus cuniculus	61-74
21232642-6	2011	In the second protocol the formation of an amide bond between carboxylic acid-coated gold nanoparticles and free surface amines of catalase using carbodiimide chemistry was performed.	Carbodiimides	146-158	catalase	Homo sapiens	131-139
21232642-9	2011	Although the carbodiimide chemistry-based bioconjugation approach exhibited a decrease in catalase activity, the carbodiimide chemistry-based bioconjugation approach resulted in more active catalase per gold nanoparticle compared with that of mercapto-undecanoic acid-stabilized biotinylated gold nanoparticles.	Carbodiimides	113-125	catalase	Homo sapiens	190-198
21586817-4	2011	CAT enzyme was linked covalently to the surface of iron oxide using carbodiimide in phosphate buffer (pH 7.4) at 4  C. The enzyme-iron oxide link was confirmed by FT-IR spectroscopy.	Carbodiimides	68-80	catalase	Homo sapiens	0-3
21315682-1	2011	An amperometric uric acid biosensor was fabricated by immobilizing uricase (EC 1.7.3.3) onto gold nanoparticle (AuNP)/multiwalled carbon nanotube (MWCNT) layer deposited on Au electrode via carbodiimide linkage.	Carbodiimides	190-202	urate oxidase (pseudogene)	Homo sapiens	67-74
21770094-3	2011	The enzyme, uricase was covalently immobilized to the carboxyl groups of the mixed SAM of MUA/MPA through carbodiimide coupling reaction.	Carbodiimides	106-118	urate oxidase (pseudogene)	Homo sapiens	12-19
21415521-2	2011	PGA film was prepared on a cellulose acetate-coated Pt-Ir wire electrode, and GOx was covalently immobilized on its surface using water-soluble carbodiimide.	Carbodiimides	144-156	hydroxyacid oxidase 1	Homo sapiens	78-81
21185167-4	2011	Amino (NH(2))-terminated IgE aptamers were covalently attached to carboxyl (COOH)-modified NCD surfaces using carbodiimide chemistry.	Carbodiimides	110-122	immunoglobulin heavy constant epsilon	Homo sapiens	25-28
21446962-3	2011	The key component of this assay system, an estradiol-reporter enzyme conjugate, was prepared by covalently binding beta-estradiol-6-(O-carboxymethyl)oxime to glucose-6-phosphate dehydrogenase (G6PDH) by an N-hydroxysuccinimide-enhanced, carbodiimide-mediated coupling reaction.	Carbodiimides	237-249	glucose-6-phosphate dehydrogenase	Homo sapiens	158-191
21446962-3	2011	The key component of this assay system, an estradiol-reporter enzyme conjugate, was prepared by covalently binding beta-estradiol-6-(O-carboxymethyl)oxime to glucose-6-phosphate dehydrogenase (G6PDH) by an N-hydroxysuccinimide-enhanced, carbodiimide-mediated coupling reaction.	Carbodiimides	237-249	glucose-6-phosphate dehydrogenase	Homo sapiens	193-198
21090730-1	2010	An efficient synthesis of 2-amino-oxazolo[4,5-c]quinoline TRPV1 antagonists is described via a thiourea formation/carbodiimide cyclization sequence.	Carbodiimides	114-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
19778179-0	2010	Carbodiimide conjugation of fibronectin on collagen basal lamina analogs enhances cellular binding domains and epithelialization.	Carbodiimides	0-12	fibronectin 1	Homo sapiens	28-39
21137981-1	2010	This is most probably the first time that covalently binding of Human serum paraoxonase 1 (PON1) to superparamagnetic magnetite nanoparticles via carbodiimide activation was investigated and presented in this study.	Carbodiimides	146-158	paraoxonase 1	Homo sapiens	76-89
21137981-1	2010	This is most probably the first time that covalently binding of Human serum paraoxonase 1 (PON1) to superparamagnetic magnetite nanoparticles via carbodiimide activation was investigated and presented in this study.	Carbodiimides	146-158	paraoxonase 1	Homo sapiens	91-95
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	Carbodiimides	300-312	galactosidase beta 1	Homo sapiens	128-146
20441961-3	2010	The alpha-Lac immobilization was achieved through the covalent binding between MCSNP amino groups and alpha-Lac carboxylic moieties using the well-known tandem carbodiimide (EDC) and hydroxysulfosuccinimide (NHS).	Carbodiimides	160-172	lactalbumin alpha	Bos taurus	4-13
20441961-3	2010	The alpha-Lac immobilization was achieved through the covalent binding between MCSNP amino groups and alpha-Lac carboxylic moieties using the well-known tandem carbodiimide (EDC) and hydroxysulfosuccinimide (NHS).	Carbodiimides	160-172	lactalbumin alpha	Bos taurus	102-111
20516321-1	2010	BACKGROUND: Tendon surface modification with a synthetic biopolymer, carbodiimide-derivatized hyaluronic acid and gelatin with the addition of lubricin (CHL), has been shown to reduce gliding resistance after tendon repair in an in vitro model.	Carbodiimides	69-81	proteoglycan 4	Canis lupus familiaris	143-151
21186538-2	2010	METHODS: A rapid test kit was developed by conjugation of the HIV antigen gp41 and gp36 to 200nm super paramagnetic particles by carbodiimide (EDC) and coating of the HIV antigen gp41 and gp36 to nitrocellulose membrane.	Carbodiimides	129-141	podoplanin	Homo sapiens	83-87
20175539-6	2010	Carboxylic acid functionalized SPNs were also synthesized and conjugated to bovine serum albumin (BSA) by carbodiimide-mediated chemistry, a key step in the realization of targeted imaging using conjugated polymers.	Carbodiimides	106-118	albumin	Homo sapiens	83-96
20467129-2	2010	Two types of PGA, gamma-polyglutamic acid (PGAH) and gamma-polyglutamic acid sodium salt (PGANa), were employed to prepare GOx immobilized film by the covalent attachment of GOx using water-soluble carbodiimide (EDC).	Carbodiimides	198-210	hydroxyacid oxidase 1	Homo sapiens	123-126
19635387-2	2009	PRV was coupled to keyhole limpt hemocyanin (KLH) and bovine serum albumin (BSA) via its terminal carboxylic acid group by carbodiimide reagent.	Carbodiimides	123-135	albumin	Homo sapiens	61-74
19388090-2	2009	RGDS peptides were further immobilized under the catalyzation of water soluble carbodiimide (EDAC).	Carbodiimides	79-91	ral guanine nucleotide dissociation stimulator	Homo sapiens	0-4
19877530-2	2009	METHODS: DA was coupled to bovine serum albumin (BSA) and ovalbumin (OVA) by carbodiimide reaction.	Carbodiimides	77-89	albumin	Mus musculus	34-53
19606852-0	2009	Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.	Carbodiimides	0-12	ribonuclease A family member 1, pancreatic	Homo sapiens	52-59
17647223-4	2008	As the following stage, adhesive peptides Arg-Gly-Asp-Ser (RGDS) were grafted into the backbone of DL-PLA by using carbodiimide as a coupling agent, in order to endow DL-PLA with bioactivity and biospecificity.	Carbodiimides	115-127	ral guanine nucleotide dissociation stimulator	Homo sapiens	59-63
18948378-3	2009	The metabolites generated, the sulfenic acid, sulfinic acid, and carbodiimide derivatives, are the same as those produced by EtaA and human FMO1 and FMO3.	Carbodiimides	65-77	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	140-144
18948378-3	2009	The metabolites generated, the sulfenic acid, sulfinic acid, and carbodiimide derivatives, are the same as those produced by EtaA and human FMO1 and FMO3.	Carbodiimides	65-77	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	149-153
18507410-3	2008	The approach immobilizes the fibronectin-derived cell adhesion ligand Arg-Gly-Asp-Ser-Pro (RGDSP) using carbodiimide activation chemistry and immobilizes DNA strands on the same surface via cDNA-DNA interactions.	Carbodiimides	104-116	fibronectin 1	Mus musculus	29-40
18006054-3	2008	The ELP (VPGVG)40 was produced in Escherichia coli and conjugated with polyacrylic acid (PAA) and polyethyleneimine (PEI) using carbodiimide activation chemistry.	Carbodiimides	128-140	diazepam binding inhibitor-like 5	Rattus norvegicus	4-7
17706825-1	2007	Direct binding of alkaline phosphatase (ALP) on magnetic nanoparticles (Fe(3)O(4)) in the presence of carbodiimide (CDI) using two different methods is described.	Carbodiimides	102-114	alkaline phosphatase, placental	Homo sapiens	18-38
17680668-2	2008	Here, we describe a new biomaterial, Haptide-coated Collagen, in which the carbodiimide reagent, EDC, was used to covalently couple a Haptide (preC gamma), equivalent to the carboxy terminus of the fibrinogen gamma chain, to a cross-linked sponge composed of bovine collagen type I.	Carbodiimides	75-87	fibrinogen gamma chain	Bos taurus	198-220
17706825-1	2007	Direct binding of alkaline phosphatase (ALP) on magnetic nanoparticles (Fe(3)O(4)) in the presence of carbodiimide (CDI) using two different methods is described.	Carbodiimides	102-114	alkaline phosphatase, placental	Homo sapiens	40-43
17706825-1	2007	Direct binding of alkaline phosphatase (ALP) on magnetic nanoparticles (Fe(3)O(4)) in the presence of carbodiimide (CDI) using two different methods is described.	Carbodiimides	116-119	alkaline phosphatase, placental	Homo sapiens	18-38
17706825-1	2007	Direct binding of alkaline phosphatase (ALP) on magnetic nanoparticles (Fe(3)O(4)) in the presence of carbodiimide (CDI) using two different methods is described.	Carbodiimides	116-119	alkaline phosphatase, placental	Homo sapiens	40-43
17461603-1	2007	With the advantage of carbodiimide coupling chemistry, horse heart cytochrome c (cyt c) has been covalently immobilized onto self-assembled monolayers (SAMs) from 11-mercaptoundecanoic acid (MUDA) developed on single-crystal or polycrystalline gold substrate surfaces.	Carbodiimides	22-34	cytochrome c, somatic	Equus caballus	67-79
17243152-4	2007	NWPF discs were partially hydrolyzed, and then the carboxyl groups were coupled with leukemia inhibitory factor (LIF) in the presence of water-soluble carbodiimide.	Carbodiimides	151-163	leukemia inhibitory factor	Mus musculus	85-111
17243152-4	2007	NWPF discs were partially hydrolyzed, and then the carboxyl groups were coupled with leukemia inhibitory factor (LIF) in the presence of water-soluble carbodiimide.	Carbodiimides	151-163	leukemia inhibitory factor	Mus musculus	113-116
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Carbodiimides	137-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Carbodiimides	137-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
17461603-1	2007	With the advantage of carbodiimide coupling chemistry, horse heart cytochrome c (cyt c) has been covalently immobilized onto self-assembled monolayers (SAMs) from 11-mercaptoundecanoic acid (MUDA) developed on single-crystal or polycrystalline gold substrate surfaces.	Carbodiimides	22-34	cytochrome c, somatic	Equus caballus	81-86
16832341-4	2007	A carbodiimide crosslinker was used for crosslinking radio-labeled gastrins to membrane proteins from gastrin/PG responsive cell lines.	Carbodiimides	2-14	gastrin	Homo sapiens	67-74
16621510-3	2007	Then the tyrosinase was immobilized onto the ABDD surface by carbodiimide coupling reaction.	Carbodiimides	61-73	tyrosinase	Homo sapiens	9-19
16969466-2	2006	Organo alkali metal compounds such as (n)BuLi and (Me3Si)2NK act as excellent catalyst precursors for the addition of phosphine P-H bonds to carbodiimides, offering a general and atom-economical route to substituted phosphaguanidines, with excellent tolerability to aromatic C-Br and C-Cl bonds.	Carbodiimides	141-154	carbonyl reductase 1	Homo sapiens	275-279
16886221-1	2006	In the present study, NGF, BNDF from the neurotrophin family and IGF-1 were covalently immobilized on gelatin-tricalcium phosphate (GTG) membrane using carbodiimide.	Carbodiimides	152-164	nerve growth factor	Rattus norvegicus	22-25
16886221-1	2006	In the present study, NGF, BNDF from the neurotrophin family and IGF-1 were covalently immobilized on gelatin-tricalcium phosphate (GTG) membrane using carbodiimide.	Carbodiimides	152-164	insulin-like growth factor 1	Rattus norvegicus	65-70
16423566-3	2006	As the polymer contains pendant carboxylic groups one-step carbodiimide method was used to immobilize tyrosinase on the polymer matrix.	Carbodiimides	59-71	tyrosinase	Homo sapiens	102-112
16443618-0	2006	Fibronectin immobilization using water-soluble carbodiimide on poly-L-lactic acid for enhancing initial fibroblast attachment.	Carbodiimides	47-59	fibronectin 1	Homo sapiens	0-11
16443618-5	2006	Fibronectin is immobilized onto the hydrolyzed PLA surface through a condensation reaction between the carboxylic acid groups on the hydrolyzed PLA surface and the amino groups of fibronectin using water-soluble carbodiimide.	Carbodiimides	212-224	fibronectin 1	Homo sapiens	0-11
16443618-5	2006	Fibronectin is immobilized onto the hydrolyzed PLA surface through a condensation reaction between the carboxylic acid groups on the hydrolyzed PLA surface and the amino groups of fibronectin using water-soluble carbodiimide.	Carbodiimides	212-224	fibronectin 1	Homo sapiens	180-191
16636453-1	2006	Soluble egg shell membrane protein (SEP) prepared from the egg shell membrane by performic acid oxidation and pepsin digestion was applied to prepare a membrane conjugated with pepsin-solubilized collagen (PSC) by cross-linking with water-soluble carbodiimide.	Carbodiimides	247-259	membrane metalloendopeptidase like 1	Homo sapiens	36-39
15892146-10	2005	For sake of comparison, the reactions of [AlH3(NMe3)] and [GaH3(quin)] with the bulky carbodiimide ArN=C=NAr and the thiourea Ar(H)NC(=S)N(H)Ar were examined.	Carbodiimides	86-98	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	47-51
15784328-3	2005	Succinylation and carbodiimide modification was used to shift the isoelectric point of lysozyme to lower and higher pH values, respectively.	Carbodiimides	18-30	lysozyme	Homo sapiens	87-95
14585696-7	2004	Carbodiimide-cross-linked matrices were found to have a higher cross-link density, a higher compressive stiffness and a greater resistance to collagenase and chondroitinase, compared to non-cross-linked controls and matrices that were cross-linked by the dehydrothermal process.	Carbodiimides	0-12	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	158-172
15681200-4	2005	The sensor elements have been prepared by coating the sensor surface with tumor marker EDB-fibronectin by means of SAM technique and carbodiimide chemistry.	Carbodiimides	133-145	fibronectin 1	Homo sapiens	87-90
15478212-3	2004	Using carbodiimide chemistry, BMP-2 was directly immobilized on silk fibroin films.	Carbodiimides	6-18	bone morphogenetic protein 2	Homo sapiens	30-35
12713918-2	2003	Glucose oxidase (Gox) was immobilised onto preformed self-assembled monolayers (SAMs) (mercaptoethylamine or mercaptopropionic acid) on electroless gold via cross-linking with glutaraldehyde or covalent attachment by carbodiimide coupling.	Carbodiimides	217-229	hydroxyacid oxidase 1	Homo sapiens	0-15
12713918-2	2003	Glucose oxidase (Gox) was immobilised onto preformed self-assembled monolayers (SAMs) (mercaptoethylamine or mercaptopropionic acid) on electroless gold via cross-linking with glutaraldehyde or covalent attachment by carbodiimide coupling.	Carbodiimides	217-229	hydroxyacid oxidase 1	Homo sapiens	17-20
12944143-3	2003	[125I]-labeled carbodiimide-modified LDL ([125I])-labeled ECDI-LDL) appeared to recognize the LDL receptor on normal human skin fibroblasts, although some nonspecific binding also was detected.	Carbodiimides	15-27	low density lipoprotein receptor	Homo sapiens	94-106
12162325-3	2002	At first these matrices were partially hydrolyzed and then the carboxyl groups were coupled with RGD or insulin in the presence of water-soluble carbodiimide.	Carbodiimides	145-157	insulin	Homo sapiens	104-111
12523861-2	2003	Galactosylated surfaces were then obtained by coupling a galactose derivative (1-O-(6"-aminohexyl)-D-galactopyranoside) to the AAc graft chains with the aid of a water-soluble carbodiimide (WSC) and N-hydroxysulfosuccinimide (sulfo-NHS).	Carbodiimides	176-188	glycine-N-acyltransferase	Homo sapiens	127-130
12607772-2	2002	PROBLEM: We previously immunoneutralized gonadotrophin releasing hormone (GnRH), using an analogue of GnRH (des-1 GnRH-I), conjugated to tetanus toxoid via a carbodiimide reaction.	Carbodiimides	158-170	gonadotropin releasing hormone 1	Homo sapiens	74-78
12607772-2	2002	PROBLEM: We previously immunoneutralized gonadotrophin releasing hormone (GnRH), using an analogue of GnRH (des-1 GnRH-I), conjugated to tetanus toxoid via a carbodiimide reaction.	Carbodiimides	158-170	gonadotropin releasing hormone 1	Homo sapiens	102-106
12607772-2	2002	PROBLEM: We previously immunoneutralized gonadotrophin releasing hormone (GnRH), using an analogue of GnRH (des-1 GnRH-I), conjugated to tetanus toxoid via a carbodiimide reaction.	Carbodiimides	158-170	delta 4-desaturase, sphingolipid 1	Homo sapiens	108-113
12607772-2	2002	PROBLEM: We previously immunoneutralized gonadotrophin releasing hormone (GnRH), using an analogue of GnRH (des-1 GnRH-I), conjugated to tetanus toxoid via a carbodiimide reaction.	Carbodiimides	158-170	gonadotropin releasing hormone 1	Homo sapiens	114-120
12097281-2	2002	Analogs of syndecan-1 were produced by carbodiimide (EDAC) conjugation of glycosaminoglycan (GAG) chains to a protein scaffold, thereby generating synthetic proteoglycans that were evaluated for anticancer properties.	Carbodiimides	39-51	syndecan 1	Mus musculus	11-21
11679578-1	2001	Human cofilin possesses the tendency for self-association, as indicated by the rapid formation of dimers and oligomers when reacted with water-soluble carbodiimide, Ellman"s reagent, or glutathione disulfide.	Carbodiimides	151-163	cofilin 1	Homo sapiens	6-13
11996050-5	2002	One- and two-step carbodiimide schemes were used to immobilize lysozyme, a model biomolecule, and bone morphogenetic protein-4 (BMP-4) on the aminated surfaces.	Carbodiimides	18-30	bone morphogenetic protein 4	Mus musculus	98-126