PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28810190-2 2017 In this study, a series of 11alpha-substituted 2-methoxyestradiol analogs have been designed and synthesized targeting dual ERalpha and microtubulin. 11alpha 27-34 estrogen receptor 1 Homo sapiens 124-131 31039398-4 2019 In the same model system, novel 11alphaOHP4 metabolites were detected in its conversion by steroid-5alpha-reductase (SRD5A) types 1 and 2 yielding 11alpha-hydroxydihydroprogesterone and its conversion by cytochrome P450 17A1 (CYP17A1) yielding the hydroxylase product, 11alpha,17alpha-dihydroxyprogesterone, and the 17,20 lyase product, 11alpha-hydroxyandrostenedione. 11alpha 32-39 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 204-224 31039398-4 2019 In the same model system, novel 11alphaOHP4 metabolites were detected in its conversion by steroid-5alpha-reductase (SRD5A) types 1 and 2 yielding 11alpha-hydroxydihydroprogesterone and its conversion by cytochrome P450 17A1 (CYP17A1) yielding the hydroxylase product, 11alpha,17alpha-dihydroxyprogesterone, and the 17,20 lyase product, 11alpha-hydroxyandrostenedione. 11alpha 32-39 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 226-233