PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31032922-0	2019	Methyl 3,4-dihydroxybenzoate protects against d-galN/LPS-induced acute liver injury by inhibiting inflammation and apoptosis in mice.	methyl 3,4-dihydroxybenzoate	0-28	galanin and GMAP prepropeptide	Mus musculus	48-52
31032922-1	2019	OBJECTIVES: Aimed to investigate the effect and mechanism of methyl 3,4-dihydroxybenzoate (MDHB) on d-galactosamine/lipopolysaccharide (d-galN/LPS)-induced acute liver failure (ALF).	methyl 3,4-dihydroxybenzoate	61-89	galanin and GMAP prepropeptide	Mus musculus	138-142
31032922-1	2019	OBJECTIVES: Aimed to investigate the effect and mechanism of methyl 3,4-dihydroxybenzoate (MDHB) on d-galactosamine/lipopolysaccharide (d-galN/LPS)-induced acute liver failure (ALF).	methyl 3,4-dihydroxybenzoate	91-95	galanin and GMAP prepropeptide	Mus musculus	138-142
31032922-4	2019	CONCLUSIONS: Methyl 3,4-dihydroxybenzoate can effectively resist d-galN/LPS-induced acute liver failure, which is related to the inhibition of inflammation and apoptosis.	methyl 3,4-dihydroxybenzoate	13-41	galanin and GMAP prepropeptide	Mus musculus	67-71
29874838-0	2018	Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16.	methyl 3,4-dihydroxybenzoate	0-28	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	113-118
30633922-10	2019	Thus our results suggest that MDHB protects retina against AOH injury by inhibiting oxidative stress, activating the BDNF/AKT signaling and inhibiting inflammatory pathways.	methyl 3,4-dihydroxybenzoate	30-34	brain derived neurotrophic factor	Mus musculus	117-121
30633922-10	2019	Thus our results suggest that MDHB protects retina against AOH injury by inhibiting oxidative stress, activating the BDNF/AKT signaling and inhibiting inflammatory pathways.	methyl 3,4-dihydroxybenzoate	30-34	thymoma viral proto-oncogene 1	Mus musculus	122-125
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	60-88	synapsin I	Homo sapiens	202-212
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	60-88	synapsin I	Homo sapiens	214-218
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	60-88	discs large MAGUK scaffold protein 4	Homo sapiens	224-255
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	60-88	discs large MAGUK scaffold protein 4	Homo sapiens	257-263
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	90-94	synapsin I	Homo sapiens	202-212
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	90-94	synapsin I	Homo sapiens	214-218
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	90-94	discs large MAGUK scaffold protein 4	Homo sapiens	224-255
30581378-4	2018	Here, we reported the characterization of a small molecule (Methyl 3,4-dihydroxybenzoate; MDHB) that selectively induces hippocampal NSCs to differentiate into cholinergic motor neurons which expressed synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD-95).	methyl 3,4-dihydroxybenzoate	90-94	discs large MAGUK scaffold protein 4	Homo sapiens	257-263
30581378-5	2018	Studies on the mechanisms revealed that MDHB induced the hippocampal NSCs differentiation into cholinergic motor neurons by inhibiting AKT phosphorylation and activating autophosphorylation of GSK3beta at tyrosine 216.	methyl 3,4-dihydroxybenzoate	40-44	glycogen synthase kinase 3 beta	Homo sapiens	193-201
30581378-6	2018	Furthermore, we found that MDHB enhanced beta-catenin degradation and abolished its entering into the nucleus.	methyl 3,4-dihydroxybenzoate	27-31	catenin beta 1	Homo sapiens	41-53
29874838-0	2018	Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16.	methyl 3,4-dihydroxybenzoate	0-28	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	119-125
29874838-6	2018	Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans.	methyl 3,4-dihydroxybenzoate	50-54	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	82-87
29874838-6	2018	Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans.	methyl 3,4-dihydroxybenzoate	50-54	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	127-132
29874838-6	2018	Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans.	methyl 3,4-dihydroxybenzoate	150-154	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	127-132
29874838-7	2018	Moreover, MDHB enhances the nuclear localization of daf-16/FoxO, and then modulates the expressions of genes that positively correlate with defenses against stress and longevity in C. elegans.	methyl 3,4-dihydroxybenzoate	10-14	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	52-58
29874838-8	2018	Therefore, our results indicate that MDHB at least partially acts as a modulator of the daf-2/daf-16 pathway to extend the lifespan of C. elegans, and MDHB might be a promising therapeutic agent for age-related diseases.	methyl 3,4-dihydroxybenzoate	37-41	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	88-93
29874838-8	2018	Therefore, our results indicate that MDHB at least partially acts as a modulator of the daf-2/daf-16 pathway to extend the lifespan of C. elegans, and MDHB might be a promising therapeutic agent for age-related diseases.	methyl 3,4-dihydroxybenzoate	37-41	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	94-100
25807175-0	2015	Methyl 3,4-dihydroxybenzoate promote rat cortical neurons survival and neurite outgrowth through the adenosine A2a receptor/PI3K/Akt signaling pathway.	methyl 3,4-dihydroxybenzoate	0-28	adenosine A2a receptor	Rattus norvegicus	101-123
28709891-4	2017	MDHB or an equal volume of vehicle was intraperitoneally injected in rd10 mice daily from postnatal day 12 (P12) to P26.	methyl 3,4-dihydroxybenzoate	0-4	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	69-73
28709891-8	2017	The visual behavior and ERG responses were also greatly enhanced in MDHB-treated rd10 mice.	methyl 3,4-dihydroxybenzoate	68-72	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	81-85
28709891-9	2017	Mechanistically, following MDHB treatment, the number of TUNEL-positive cells was decreased in rd10 retina, and the expression of brain-derived neurotrophic factor (BDNF) protein and phosphorylated tropomyosin-related kinase B (TrkB) receptor were increased.	methyl 3,4-dihydroxybenzoate	27-31	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	95-99
28709891-9	2017	Mechanistically, following MDHB treatment, the number of TUNEL-positive cells was decreased in rd10 retina, and the expression of brain-derived neurotrophic factor (BDNF) protein and phosphorylated tropomyosin-related kinase B (TrkB) receptor were increased.	methyl 3,4-dihydroxybenzoate	27-31	brain derived neurotrophic factor	Mus musculus	130-163
28709891-9	2017	Mechanistically, following MDHB treatment, the number of TUNEL-positive cells was decreased in rd10 retina, and the expression of brain-derived neurotrophic factor (BDNF) protein and phosphorylated tropomyosin-related kinase B (TrkB) receptor were increased.	methyl 3,4-dihydroxybenzoate	27-31	brain derived neurotrophic factor	Mus musculus	165-169
28709891-9	2017	Mechanistically, following MDHB treatment, the number of TUNEL-positive cells was decreased in rd10 retina, and the expression of brain-derived neurotrophic factor (BDNF) protein and phosphorylated tropomyosin-related kinase B (TrkB) receptor were increased.	methyl 3,4-dihydroxybenzoate	27-31	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	198-226
28709891-9	2017	Mechanistically, following MDHB treatment, the number of TUNEL-positive cells was decreased in rd10 retina, and the expression of brain-derived neurotrophic factor (BDNF) protein and phosphorylated tropomyosin-related kinase B (TrkB) receptor were increased.	methyl 3,4-dihydroxybenzoate	27-31	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	228-232
28709891-10	2017	Furthermore, blocking TrkB using the antagonist ANA-12 prevented the protective effect of MDHB on photoreceptor survival and structure.	methyl 3,4-dihydroxybenzoate	90-94	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	22-26
28709891-11	2017	MDHB treatment also inhibited microglial activation and Muller cell gliosis in rd10 retina.	methyl 3,4-dihydroxybenzoate	0-4	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	79-83
28709891-12	2017	In conclusion, MDHB treatment delays retinal degeneration in rd10 mice and preserves retinal structure and functions.	methyl 3,4-dihydroxybenzoate	15-19	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	61-65
25807175-0	2015	Methyl 3,4-dihydroxybenzoate promote rat cortical neurons survival and neurite outgrowth through the adenosine A2a receptor/PI3K/Akt signaling pathway.	methyl 3,4-dihydroxybenzoate	0-28	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
25807175-3	2015	In the present study, we focused on the mechanism of its neurotrophic effect; the results showed that MDHB-induced upregulation of neuronal survival and neurite outgrowth in cultured primary cortical neurons could be blocked by the adenosine A2a receptor inhibitor (ZM241385) and the phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	methyl 3,4-dihydroxybenzoate	102-106	adenosine A2a receptor	Rattus norvegicus	232-254
25807175-3	2015	In the present study, we focused on the mechanism of its neurotrophic effect; the results showed that MDHB-induced upregulation of neuronal survival and neurite outgrowth in cultured primary cortical neurons could be blocked by the adenosine A2a receptor inhibitor (ZM241385) and the phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	methyl 3,4-dihydroxybenzoate	102-106	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	284-309
25807175-4	2015	Subsequently, we found that the upregulation of Akt phosphorylation by MDHB could be suppressed by A2a-R and PI3K-specific inhibitor, but not the Trk-R inhibitor.	methyl 3,4-dihydroxybenzoate	71-75	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
25807175-5	2015	Furthermore, MDHB could activate Akt in a concentration-dependent manner.	methyl 3,4-dihydroxybenzoate	13-17	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
25807175-6	2015	These results suggested that activation of the PI3K/Akt signaling pathway may be involved in the MDHB-induced neurotrophic effects and MDHB could be a candidate compound to develop drugs for neurodegenerative disease.	methyl 3,4-dihydroxybenzoate	97-101	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
24849190-6	2014	MDHB also obstructed H2O2-induced apoptosis by regulating the expression of Bcl-2 and Bax, as well as suppressing the activation of caspase 9 and caspase 3.	methyl 3,4-dihydroxybenzoate	0-4	B cell leukemia/lymphoma 2	Mus musculus	76-81
25456844-0	2014	Methyl 3,4-dihydroxybenzoate extends the lifespan of Caenorhabditis elegans, partly via W06A7.4 gene.	methyl 3,4-dihydroxybenzoate	0-28	Uncharacterized protein	Caenorhabditis elegans	88-95
25456844-6	2014	Our findings demonstrate that W06A7.4 is a potentially positive determinant of the MDHB induced C. elegans" lifespan extension effect.	methyl 3,4-dihydroxybenzoate	83-87	Uncharacterized protein	Caenorhabditis elegans	30-37
24849190-6	2014	MDHB also obstructed H2O2-induced apoptosis by regulating the expression of Bcl-2 and Bax, as well as suppressing the activation of caspase 9 and caspase 3.	methyl 3,4-dihydroxybenzoate	0-4	BCL2-associated X protein	Mus musculus	86-89
24849190-6	2014	MDHB also obstructed H2O2-induced apoptosis by regulating the expression of Bcl-2 and Bax, as well as suppressing the activation of caspase 9 and caspase 3.	methyl 3,4-dihydroxybenzoate	0-4	caspase 9	Mus musculus	132-141
24849190-6	2014	MDHB also obstructed H2O2-induced apoptosis by regulating the expression of Bcl-2 and Bax, as well as suppressing the activation of caspase 9 and caspase 3.	methyl 3,4-dihydroxybenzoate	0-4	caspase 3	Mus musculus	146-155
23861072-8	2013	In addition, MDHB could increase the level of Bcl-2, decrease the level of Bax, and inhibit the activation of caspase-9 and caspase-3 in Abeta25-35 -treated primary cortical neurons.	methyl 3,4-dihydroxybenzoate	13-17	BCL2, apoptosis regulator	Rattus norvegicus	46-51
23861072-8	2013	In addition, MDHB could increase the level of Bcl-2, decrease the level of Bax, and inhibit the activation of caspase-9 and caspase-3 in Abeta25-35 -treated primary cortical neurons.	methyl 3,4-dihydroxybenzoate	13-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	75-78
23861072-8	2013	In addition, MDHB could increase the level of Bcl-2, decrease the level of Bax, and inhibit the activation of caspase-9 and caspase-3 in Abeta25-35 -treated primary cortical neurons.	methyl 3,4-dihydroxybenzoate	13-17	caspase 9	Rattus norvegicus	110-119
23861072-8	2013	In addition, MDHB could increase the level of Bcl-2, decrease the level of Bax, and inhibit the activation of caspase-9 and caspase-3 in Abeta25-35 -treated primary cortical neurons.	methyl 3,4-dihydroxybenzoate	13-17	caspase 3	Rattus norvegicus	124-133
21509397-7	2011	We have successfully employed MDHB to detect the relative expression levels of four colorectal cancer (CRC)-related genes (c-myc, COX-2, MMP7, and DPEP1) in 8 tissue samples and 9 stool samples from CRC patients, giving the detection rates of 100% and 77%, respectively.	methyl 3,4-dihydroxybenzoate	30-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	123-128
21509397-7	2011	We have successfully employed MDHB to detect the relative expression levels of four colorectal cancer (CRC)-related genes (c-myc, COX-2, MMP7, and DPEP1) in 8 tissue samples and 9 stool samples from CRC patients, giving the detection rates of 100% and 77%, respectively.	methyl 3,4-dihydroxybenzoate	30-34	matrix metallopeptidase 7	Homo sapiens	137-141
25722684-3	2012	Moreover, MDHB induced brain-derived neurotrophic factor expression.	methyl 3,4-dihydroxybenzoate	10-14	brain-derived neurotrophic factor	Rattus norvegicus	23-56
25722684-4	2012	These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression.	methyl 3,4-dihydroxybenzoate	28-32	brain-derived neurotrophic factor	Rattus norvegicus	104-137