PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21693180-5	2011	A significant dose dependent induction in the levels of mRNA expression of genes of steroidogenic acute regulatory protein (STAR), cytochrome P45011A1, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), and other steroidogenic proteins were observed in cells exposed to ATZ.	Atrazine	267-270	steroidogenic acute regulatory protein	Rattus norvegicus	84-122
22655377-6	2012	Superoxide dismutase, peroxidase and catalase in roots were up-regulated by atrazine exposure at 1 mg/L compared to the control and malondialdehyde content in roots was enhanced when atrazine exposure concentration reached 10 mg/L.	Atrazine	76-84	superoxide dismutase	Zea mays	0-20
22655377-6	2012	Superoxide dismutase, peroxidase and catalase in roots were up-regulated by atrazine exposure at 1 mg/L compared to the control and malondialdehyde content in roots was enhanced when atrazine exposure concentration reached 10 mg/L.	Atrazine	76-84	peroxidase 1	Zea mays	22-32
22655377-6	2012	Superoxide dismutase, peroxidase and catalase in roots were up-regulated by atrazine exposure at 1 mg/L compared to the control and malondialdehyde content in roots was enhanced when atrazine exposure concentration reached 10 mg/L.	Atrazine	183-191	superoxide dismutase	Zea mays	0-20
22792398-2	2012	The induction by four herbicides (2,4-D, atrazine, metolachlor and primisulfuron) and a herbicide safener (dichlormid) on the expression of three genes, ZmGST27, ZmGT1 and ZmMRP1, encoding respectively a glutathione-S-transferase, a glutathione transporter and an ATP-binding cassette (ABC) transporter was studied in maize.	Atrazine	41-49	glutathione S-transferase 4	Zea mays	153-160
22792398-2	2012	The induction by four herbicides (2,4-D, atrazine, metolachlor and primisulfuron) and a herbicide safener (dichlormid) on the expression of three genes, ZmGST27, ZmGT1 and ZmMRP1, encoding respectively a glutathione-S-transferase, a glutathione transporter and an ATP-binding cassette (ABC) transporter was studied in maize.	Atrazine	41-49	oligopeptide transporter 3	Zea mays	162-167
22792398-4	2012	The expression of ZmGST27 and ZmMRP1 was up-regulated by all five compounds, whereas that of ZmGT1 was increased by atrazine, metolachlor, primisulfuron and dichlormid, but not by 2,4-D.	Atrazine	116-124	oligopeptide transporter 3	Zea mays	93-98
22310298-11	2012	The urea herbicide diuron and the triazine herbicide atrazine induced CYP2B6 mRNA more than 10-fold, but did not activate CAR indicating that some pesticides may induce CYP2B6 via CAR-independent mechanisms.	Atrazine	53-61	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	70-76
22310298-11	2012	The urea herbicide diuron and the triazine herbicide atrazine induced CYP2B6 mRNA more than 10-fold, but did not activate CAR indicating that some pesticides may induce CYP2B6 via CAR-independent mechanisms.	Atrazine	53-61	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	169-175
22310298-11	2012	The urea herbicide diuron and the triazine herbicide atrazine induced CYP2B6 mRNA more than 10-fold, but did not activate CAR indicating that some pesticides may induce CYP2B6 via CAR-independent mechanisms.	Atrazine	53-61	nuclear receptor subfamily 1 group I member 3	Homo sapiens	180-183
21693180-5	2011	A significant dose dependent induction in the levels of mRNA expression of genes of steroidogenic acute regulatory protein (STAR), cytochrome P45011A1, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), and other steroidogenic proteins were observed in cells exposed to ATZ.	Atrazine	267-270	steroidogenic acute regulatory protein	Rattus norvegicus	124-128
22032520-1	2011	BACKGROUND: Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world.	Atrazine	12-20	ataxia telangiectasia and Rad3 related	Mus musculus	78-81
22000761-8	2011	Estimated "dose" of atrazine and chlorotriazine from tap water was inversely related to mean mid-luteal estradiol metabolite.	Atrazine	20-28	nuclear RNA export factor 1	Homo sapiens	53-56
21707270-7	2011	Atrazine was the predominant triazine, detectable in many spring water locations, tap and bottled water, ranging (mean) from 0-57 (9), 0-44 (4), and 0-4 (1) ng l(-1), respectively.	Atrazine	0-8	nuclear RNA export factor 1	Homo sapiens	82-85
21768606-6	2011	Atrazine induces mammary tumors in aging female SD rats by suppressing the luteinizing hormone surge, thereby supporting a state of persistent estrus and prolonged exposure to endogenous estrogen and prolactin.	Atrazine	0-8	prolactin	Rattus norvegicus	200-209
21404018-9	2011	Also, significant increase in the activities of SOD, CAT, GPx, and GST were observed in atrazine treated group compared to controls (P < 0.05).	Atrazine	88-96	catalase	Rattus norvegicus	53-56
21404018-9	2011	Also, significant increase in the activities of SOD, CAT, GPx, and GST were observed in atrazine treated group compared to controls (P < 0.05).	Atrazine	88-96	hematopoietic prostaglandin D synthase	Rattus norvegicus	67-70
21404018-11	2011	Administration of atrazine significantly inhibits the activities of G-6-PD and membrane ATPases such as Na(+)/K(+)-ATPase, Mg(2+)-ATPase, and Ca(2+)-ATPase (P < 0.05).	Atrazine	18-26	glucose-6-phosphate dehydrogenase	Rattus norvegicus	68-74
21404018-13	2011	Furthermore, supplementation of melatonin significantly modulates the atrazine-induced changes in LPO level, total lipids, total ATPases, GSH, and antioxidant enzymes in erythrocytes.	Atrazine	70-78	lactoperoxidase	Rattus norvegicus	98-101
21645916-1	2011	The energy consumptions of conventional ozonation and the AOPs O(3)/H(2)O(2) and UV/H(2)O(2) for transformation of organic micropollutants, namely atrazine (ATR), sulfamethoxazole (SMX) and N-nitrosodimethylamine (NDMA) were compared.	Atrazine	147-155	ATR serine/threonine kinase	Homo sapiens	157-160
21660819-11	2011	Atrazine does not appear to interact strongly with estrogen receptors alpha or beta but may interact with putative estrogen receptor GPR30 (G-protein-coupled receptor).	Atrazine	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	133-138
21428399-3	2011	The TiO(2)/CNTs composite samples were characterized by TGA-DSC, TEM, UV-vis DRS, XRD and BET, to explain the reason for efficient degradation and adsorption process of atrazine.	Atrazine	169-177	T-box transcription factor 1	Homo sapiens	56-59
21428399-3	2011	The TiO(2)/CNTs composite samples were characterized by TGA-DSC, TEM, UV-vis DRS, XRD and BET, to explain the reason for efficient degradation and adsorption process of atrazine.	Atrazine	169-177	MFT2	Homo sapiens	65-68
21428399-3	2011	The TiO(2)/CNTs composite samples were characterized by TGA-DSC, TEM, UV-vis DRS, XRD and BET, to explain the reason for efficient degradation and adsorption process of atrazine.	Atrazine	169-177	delta/notch like EGF repeat containing	Homo sapiens	90-93
21192674-3	2011	For sensing, we prepared two different sets of microparticles: one modified with atrazine-conjugated bovine serum albumin (BSA-2d) and ssDNA-J1(up) and the other with bromopropylate-conjugated aminodextran (AD-155) and ssDNA-J2(up).	Atrazine	81-89	albumin	Homo sapiens	108-121
20083397-2	2011	Atrazine administered to rats orally at a dose of 120 mg/kg caused an inhibition in the activity of glutathione-S-transferase and an increase in malondialdehyde formation in the liver, testis and epididymis.	Atrazine	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	100-125
20083397-4	2011	Furthermore, hepatic glutathione and lactate dehydrogenase activity increased while epididymal catalase, ascorbate content, hepatic aspartate aminotransferase and glutathione peroxidase activities in all the tissues decreased in the atrazine-treated animals.	Atrazine	233-241	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	132-158
20138743-6	2011	The activities of antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly increased following atrazine administration and vitamin E treatment could restore these activities.	Atrazine	163-171	catalase	Rattus norvegicus	61-69
20138743-6	2011	The activities of antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly increased following atrazine administration and vitamin E treatment could restore these activities.	Atrazine	163-171	hematopoietic prostaglandin D synthase	Rattus norvegicus	98-123
21126571-5	2011	Atrazine (10 muM), but not its metabolite, 2-chloro-4,6-diamino-1,2,5-triazine (DACT), significantly increased estradiol production and aromatase activity in granulosa cell cultures only when measured for 1-h following 24h of exposure.	Atrazine	0-8	latexin	Homo sapiens	13-16
21109350-0	2011	Experimental design methodology applied to electrochemical oxidation of the herbicide atrazine using Ti/IrO(2) and Ti/SnO(2) circular anode electrodes.	Atrazine	86-94	strawberry notch homolog 2	Homo sapiens	118-121
21109350-1	2011	The degradation of the herbicide atrazine in aqueous medium (initial concentration of 100 mug l(-1)) has been studied by electrooxidation process using Ti/IrO(2) and Ti/SnO(2) circular anode electrodes.	Atrazine	33-41	strawberry notch homolog 2	Homo sapiens	169-172
20624442-0	2011	Early exposure to low doses of atrazine affects behavior in juvenile and adult CD1 mice.	Atrazine	31-39	CD1 antigen complex	Mus musculus	79-82
22073207-2	2011	This enhanced atrazine tolerance mutant was shown to be affected in the promoter structure and in the regulation of expression of the APL4 isoform of ADP-glucose pyrophosphorylase, a key enzyme of the starch biosynthesis pathway, thus resulting in decrease of APL4 mRNA levels.	Atrazine	14-22	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	134-138
21488492-9	2011	If producers know their atrazine use history, soil pH, and OM content, they should be able to identify fields exhibiting enhanced atrazine degradation using our CART Model.	Atrazine	130-138	CART prepropeptide	Homo sapiens	161-165
22073207-2	2011	This enhanced atrazine tolerance mutant was shown to be affected in the promoter structure and in the regulation of expression of the APL4 isoform of ADP-glucose pyrophosphorylase, a key enzyme of the starch biosynthesis pathway, thus resulting in decrease of APL4 mRNA levels.	Atrazine	14-22	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	260-264
22073207-5	2011	Given the effects of exogenous sugar treatments and of endogenous sugar levels on atrazine tolerance in wild-type Arabidopsis plantlets, atrazine tolerance of this apl4 mutant is discussed in terms of perception of carbon status and of investment of sugar allocation in xenobiotic and oxidative stress responses.	Atrazine	137-145	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	164-168
21114466-1	2011	The effect of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1, 3, 5-triazine) on the activity of some antioxidative enzymes (superoxide dismutase, SOD; catalase, CAT; and guaiacol peroxidase, POD) and DNA damage induced by atrazine were investigated in zebra fish (Danio rerio).	Atrazine	14-22	catalase	Danio rerio	165-168
21126571-6	2011	In H295R cells, atrazine (10 muM) increased estradiol and estrone production.	Atrazine	16-24	latexin	Homo sapiens	29-32
21126571-7	2011	Importantly, atrazine (10 muM) increased progesterone production from both cell types suggesting a broader effect of atrazine on steroidogenesis.	Atrazine	13-21	latexin	Homo sapiens	26-29
21126571-7	2011	Importantly, atrazine (10 muM) increased progesterone production from both cell types suggesting a broader effect of atrazine on steroidogenesis.	Atrazine	117-125	latexin	Homo sapiens	26-29
20855138-3	2010	The single-point organic carbon (OC)-normalized distribution coefficients (K(OC)) of atrazine for the isolated HA1, NHC1 and BC1 from sediment 1 (ST1) were 36, 550, and 1470 times greater than that of ST1, respectively, indicating the importance of sediment organic matter, particularly the condensed fractions (NHC and BC).	Atrazine	85-93	Rho GTPase activating protein 45	Homo sapiens	111-114
20529762-0	2010	Atrazine binds to the growth hormone-releasing hormone receptor and affects growth hormone gene expression.	Atrazine	0-8	growth hormone releasing hormone receptor	Homo sapiens	22-63
20667998-5	2010	Atrazine also stimulated the expression of mRNA transcripts for steroidogenic factor-1, steroidogenic acute regulatory protein, cytochrome P450 (CYP)17A1, and 17beta-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17betaHSD.	Atrazine	0-8	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	64-86
20667998-5	2010	Atrazine also stimulated the expression of mRNA transcripts for steroidogenic factor-1, steroidogenic acute regulatory protein, cytochrome P450 (CYP)17A1, and 17beta-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17betaHSD.	Atrazine	0-8	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	128-153
20667998-5	2010	Atrazine also stimulated the expression of mRNA transcripts for steroidogenic factor-1, steroidogenic acute regulatory protein, cytochrome P450 (CYP)17A1, and 17beta-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17betaHSD.	Atrazine	0-8	aldo-keto reductase family 1, member C12	Rattus norvegicus	159-194
20667998-5	2010	Atrazine also stimulated the expression of mRNA transcripts for steroidogenic factor-1, steroidogenic acute regulatory protein, cytochrome P450 (CYP)17A1, and 17beta-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17betaHSD.	Atrazine	0-8	aldo-keto reductase family 1, member C12	Rattus norvegicus	196-199
20667998-5	2010	Atrazine also stimulated the expression of mRNA transcripts for steroidogenic factor-1, steroidogenic acute regulatory protein, cytochrome P450 (CYP)17A1, and 17beta-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17betaHSD.	Atrazine	0-8	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	229-236
20529762-0	2010	Atrazine binds to the growth hormone-releasing hormone receptor and affects growth hormone gene expression.	Atrazine	0-8	growth hormone 1	Homo sapiens	22-36
20529762-5	2010	14C-ATR was used to determine its specific binding to the growth hormone-releasing hormone receptor (GHRHR).	Atrazine	4-7	growth hormone releasing hormone receptor	Rattus norvegicus	58-99
20529762-5	2010	14C-ATR was used to determine its specific binding to the growth hormone-releasing hormone receptor (GHRHR).	Atrazine	4-7	growth hormone releasing hormone receptor	Rattus norvegicus	101-106
20809547-6	2010	Additionally, transcript levels of matrix metalloproteinases (MMPs), specifically both MMP9TH and MMP18, increased in atrazine-exposed tadpoles in a dose-response test, and MMP18 increased as early as 6 h after exposure began.	Atrazine	118-126	matrix metallopeptidase 9 gene 2 L homeolog	Xenopus laevis	87-93
20809547-6	2010	Additionally, transcript levels of matrix metalloproteinases (MMPs), specifically both MMP9TH and MMP18, increased in atrazine-exposed tadpoles in a dose-response test, and MMP18 increased as early as 6 h after exposure began.	Atrazine	118-126	matrix metallopeptidase 19 L homeolog	Xenopus laevis	98-103
20809547-6	2010	Additionally, transcript levels of matrix metalloproteinases (MMPs), specifically both MMP9TH and MMP18, increased in atrazine-exposed tadpoles in a dose-response test, and MMP18 increased as early as 6 h after exposure began.	Atrazine	118-126	matrix metallopeptidase 19 L homeolog	Xenopus laevis	173-178
20809547-8	2010	Furthermore, transcript levels of the enzyme Xcyp26, an enzyme in the retinoic acid signaling pathway, significantly decreased in the intestines of tadpoles exposed to 10 or 35 mg l(-1) atrazine for 48 h. Our results suggest two mechanisms by which atrazine can disrupt tissue morphogenesis: through misregulation of MMPs that are critical in extracellular matrix remodeling throughout development and the disruption of retinoic acid signaling.	Atrazine	186-194	cytochrome P450 family 26 subfamily A member 1 S homeolog	Xenopus laevis	45-51
20809547-8	2010	Furthermore, transcript levels of the enzyme Xcyp26, an enzyme in the retinoic acid signaling pathway, significantly decreased in the intestines of tadpoles exposed to 10 or 35 mg l(-1) atrazine for 48 h. Our results suggest two mechanisms by which atrazine can disrupt tissue morphogenesis: through misregulation of MMPs that are critical in extracellular matrix remodeling throughout development and the disruption of retinoic acid signaling.	Atrazine	249-257	cytochrome P450 family 26 subfamily A member 1 S homeolog	Xenopus laevis	45-51
20045047-3	2010	We evaluated the effects of Atrazine (50 mg/kg, 200 mg/kg and 300 mg/kg) in the 3beta-hydroxysteroid dehydrogenase (3beta-HSD) expression, plasmatic and testicular estrogen and testosterone levels, androgen receptor expression and morphological changes in adult rat testes.	Atrazine	28-36	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	116-125
20830925-4	2010	Atrazine half-life (T1/2) values pooled over nonadapted soils and depths approximated historic estimates (T1/2 = 60 d).	Atrazine	0-8	interleukin 1 receptor like 1	Homo sapiens	106-117
20045047-7	2010	The results suggest that 3beta-HSD inhibition may represent an alternative mechanism through which Atrazine affects the testicular androgenesis, leading to changes in spermatogenesis.	Atrazine	99-107	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	25-34
21462711-6	2010	For the initial concentration-dependent desorption isotherms, as initial atrazine concentration increased, the values of hysteretic coefficients omega and lamda decreased, and eta values increased.	Atrazine	73-81	endothelin receptor type A	Homo sapiens	176-179
20036412-3	2010	Antioxidant enzyme activities (SOD and CAT), in addition to the GSH and MDA content, in the liver altered significantly; the mRNA levels for the genes encoding these antioxidant proteins, such as Cu/Zn-Sod, Mn-Sod, Cat, and Gpx, were up-regulated significantly in the liver when zebrafish were exposed to various concentrations of ATZ for 14d.	Atrazine	331-334	superoxide dismutase 1, soluble	Danio rerio	196-205
20036412-5	2010	Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Ucp-2 and Bcl-2, were altered significantly in high ATZ treatment groups.	Atrazine	166-169	uncoupling protein 2	Danio rerio	114-119
20036412-5	2010	Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Ucp-2 and Bcl-2, were altered significantly in high ATZ treatment groups.	Atrazine	166-169	BCL2 apoptosis regulator a	Danio rerio	124-129
21462711-8	2010	For the time-dependent desorption isotherms, lamda and eta values increased as the atrazine desorption step proceeded.	Atrazine	83-91	endothelin receptor type A	Homo sapiens	55-58
19808863-0	2010	P19 neuronal differentiation and retinoic acid metabolism as criteria to investigate atrazine, nitrite, and nitrate developmental toxicity.	Atrazine	85-93	interleukin 23 subunit alpha	Homo sapiens	0-3
19605789-7	2009	Results of these studies show that 4-day treatment with atrazine resulted in a significant reduction in the magnitude of the LH and FSH surges, and this corresponds to a decrease in GnRH neurons expressing FOS immunoreactivity.	Atrazine	56-64	gonadotropin releasing hormone 1	Rattus norvegicus	182-186
19605789-10	2009	These data indicate that atrazine affects neuroendocrine function in the female rat by actions at the level of the GnRH neuron and that the acute effects of high doses of atrazine can be reversed within 4 days after withdrawal of treatment.	Atrazine	25-33	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
19605789-10	2009	These data indicate that atrazine affects neuroendocrine function in the female rat by actions at the level of the GnRH neuron and that the acute effects of high doses of atrazine can be reversed within 4 days after withdrawal of treatment.	Atrazine	171-179	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
19874020-7	2009	The variation of OC soil sorption coefficients, Koc, was also larger for atrazine (mean Koc of 126.9 L kg(-1)) than for imazethapyr (mean Koc of 13.2 L kg(-1)).	Atrazine	73-81	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	48-51
19874020-7	2009	The variation of OC soil sorption coefficients, Koc, was also larger for atrazine (mean Koc of 126.9 L kg(-1)) than for imazethapyr (mean Koc of 13.2 L kg(-1)).	Atrazine	73-81	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	88-91
19874020-7	2009	The variation of OC soil sorption coefficients, Koc, was also larger for atrazine (mean Koc of 126.9 L kg(-1)) than for imazethapyr (mean Koc of 13.2 L kg(-1)).	Atrazine	73-81	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	88-91
19525047-5	2009	The mechanisms involved in atrazine tolerance such as mutation in psbA gene, enzymatic detoxification via P(450) or chemical hydrolysis through benzoxazinones were evaluated.	Atrazine	27-35	psbA	Lolium multiflorum	66-70
19299313-10	2009	Taken together, these findings demonstrate that high doses of atrazine affect the GnRH pulse generator in the brain and not at the level of gonadotrophs in the pituitary.	Atrazine	62-70	gonadotropin releasing hormone 1	Rattus norvegicus	82-86
19541795-4	2009	The transcription of LHR gene in Leydig cells of atrazine-treated rats was downregulated in a dose-dependent manner, which could be the reason for reduction in cAMP level and expression of cAMP-dependent genes.	Atrazine	49-57	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	21-24
19690231-1	2009	Previously, we reported that atrazine (ATR) alters steroidogenesis in male Wistar rats resulting in elevated serum corticosterone (CORT), progesterone, and estrogens.	Atrazine	29-37	cortistatin	Rattus norvegicus	131-135
19690231-1	2009	Previously, we reported that atrazine (ATR) alters steroidogenesis in male Wistar rats resulting in elevated serum corticosterone (CORT), progesterone, and estrogens.	Atrazine	39-42	cortistatin	Rattus norvegicus	131-135
19079715-0	2008	G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	111-119	G protein-coupled estrogen receptor 1	Homo sapiens	0-29
19116264-1	2009	2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (atrazine, ATR) is a toxicologically important and widely used herbicide.	Atrazine	0-53	ataxia telangiectasia and Rad3 related	Mus musculus	65-68
19116264-1	2009	2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (atrazine, ATR) is a toxicologically important and widely used herbicide.	Atrazine	55-63	ataxia telangiectasia and Rad3 related	Mus musculus	65-68
19079715-0	2008	G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	111-119	estrogen receptor 1	Homo sapiens	34-57
19079715-3	2008	OBJECTIVES: Given the ability of atrazine to exert estrogen-like activity in cancer cells, we evaluated the potential of atrazine to signal through GPR30 in stimulating biological responses in cancer cells.	Atrazine	121-129	G protein-coupled estrogen receptor 1	Homo sapiens	148-153
19079715-6	2008	Interestingly, atrazine induced extracellular signal-regulated kinase (ERK) phosphorylation and the expression of estrogen target genes.	Atrazine	15-23	mitogen-activated protein kinase 1	Homo sapiens	32-69
19079715-6	2008	Interestingly, atrazine induced extracellular signal-regulated kinase (ERK) phosphorylation and the expression of estrogen target genes.	Atrazine	15-23	mitogen-activated protein kinase 1	Homo sapiens	71-74
19079715-7	2008	Using specific signaling inhibitors and gene silencing, we demonstrated that atrazine stimulated the proliferation of ovarian cancer cells through the GPR30-epidermal growth factor receptor transduction pathway and the involvement of ERalpha.	Atrazine	77-85	G protein-coupled estrogen receptor 1	Homo sapiens	151-156
19079715-7	2008	Using specific signaling inhibitors and gene silencing, we demonstrated that atrazine stimulated the proliferation of ovarian cancer cells through the GPR30-epidermal growth factor receptor transduction pathway and the involvement of ERalpha.	Atrazine	77-85	epidermal growth factor receptor	Homo sapiens	157-189
19079715-7	2008	Using specific signaling inhibitors and gene silencing, we demonstrated that atrazine stimulated the proliferation of ovarian cancer cells through the GPR30-epidermal growth factor receptor transduction pathway and the involvement of ERalpha.	Atrazine	77-85	estrogen receptor 1	Homo sapiens	234-241
19079715-9	2008	On the basis of the present data, atrazine should be included among the environmental contaminants potentially able to signal via GPR30 in eliciting estrogenic action.	Atrazine	34-42	G protein-coupled estrogen receptor 1	Homo sapiens	130-135
18972401-6	2008	Results indicate that atrazine exposure caused a significant inhibition of AChE activity and induction of oxidative stress in terms of increased malondialdehyde (MDA) levels.	Atrazine	22-30	acetylcholinesterase	Rattus norvegicus	75-79
17692527-5	2008	The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90.	Atrazine	27-35	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	104-109
19069660-0	2008	[Effect of Atrazine on the content of calcium and expression of calmodulin in splenocytes of mice].	Atrazine	11-19	calmodulin 2	Mus musculus	64-74
19069660-9	2008	CONCLUSION: Atrazine could induced the increase of calcium concentration and the depression of the expression of CaM in splenocytes of mice.	Atrazine	12-20	calmodulin 2	Mus musculus	113-116
17692527-5	2008	The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90.	Atrazine	27-35	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	340-345
17692527-5	2008	The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90.	Atrazine	216-224	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	104-109
17692527-5	2008	The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90.	Atrazine	216-224	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	340-345
21825795-3	2008	We report the label-free detection of highly specific atrazine antibody-antigen interactions at the nanometer scale on microcantilevers, with 1 ppt (past per trillion) sensitivity.	Atrazine	54-62	tachykinin precursor 1	Homo sapiens	144-147
18055106-6	2008	NF90 maintained above 90% of atrazine rejection and approximately 80% of dimethoate rejection regardless of the changes in solution"s pH.	Atrazine	29-37	interleukin enhancer binding factor 3	Homo sapiens	0-4
18055106-7	2008	Thus, NF90 is deemed the more suitable nanofiltration membrane for atrazine and dimethoate retention from aqueous solution compared to NF200, NF270 and DK.	Atrazine	67-75	interleukin enhancer binding factor 3	Homo sapiens	6-10
19226843-3	2008	Frequent use of atrazine in maize monoculture did select for plants having a Ser-264-Gly mutation on the psbA gene resulting in atrazine-resistance and cross-resistance to other Photosystem (PS) II-inhibitors.	Atrazine	16-24	photosystem II protein D1	Zea mays	105-109
18237303-5	2008	Plasmid profiles and Southern blot analyses revealed that the evolved strain, unlike the ancestral strain, presented a tandem duplication of the atzB gene encoding the second enzyme of the atrazine catabolic pathway responsible for the transformation of hydroxyatrazine to N-isopropylammelide.	Atrazine	189-197	atzB	Pseudomonas sp. ADP	145-149
17587496-10	2008	Of all four membranes, NF90 showed the best performance in retention of dimethoate and atrazine in water.	Atrazine	87-95	interleukin enhancer binding factor 3	Homo sapiens	23-27
19016562-4	2008	The interconnected macropores are favorable for the rapid transport of atrazine in polymer films, whereas the inherent high affinity of nanocavites distributed in thin polymer walls allows MIPP to recognize atrazine with high specificity.	Atrazine	207-215	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	189-193
19016562-5	2008	More importantly, the atrazine recognition events of the created nanocavities can be directly transferred (label-free) into a readable optical signal through a change in Bragg diffraction of the ordered macropores array of MIPP and thereby induce color changes that can be detected by the naked eye.	Atrazine	22-30	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	223-227
19226843-3	2008	Frequent use of atrazine in maize monoculture did select for plants having a Ser-264-Gly mutation on the psbA gene resulting in atrazine-resistance and cross-resistance to other Photosystem (PS) II-inhibitors.	Atrazine	128-136	photosystem II protein D1	Zea mays	105-109
17407313-1	2007	Intercalation of vermiculite with Fe(III) polyhydroxy cations at 1:1 and 2:1 [OH-]/[Fe(III)] molar ratios increases the affinity of the clay mineral toward atrazine in comparison with potassium saturated vermiculite.	Atrazine	156-164	angiotensin II receptor type 1	Homo sapiens	62-76
17662328-7	2007	In addition, atrazine exposure decreased the expression of the costimulatory molecule CD86 and it downregulated the expression of the CD11b and CD11c accessory molecules and the myeloid developmental marker CD14.	Atrazine	13-21	CD86 antigen	Mus musculus	86-90
17662328-7	2007	In addition, atrazine exposure decreased the expression of the costimulatory molecule CD86 and it downregulated the expression of the CD11b and CD11c accessory molecules and the myeloid developmental marker CD14.	Atrazine	13-21	integrin alpha M	Mus musculus	134-139
17662328-7	2007	In addition, atrazine exposure decreased the expression of the costimulatory molecule CD86 and it downregulated the expression of the CD11b and CD11c accessory molecules and the myeloid developmental marker CD14.	Atrazine	13-21	integrin alpha X	Mus musculus	144-149
17662328-7	2007	In addition, atrazine exposure decreased the expression of the costimulatory molecule CD86 and it downregulated the expression of the CD11b and CD11c accessory molecules and the myeloid developmental marker CD14.	Atrazine	13-21	CD14 antigen	Mus musculus	207-211
17293001-7	2007	Sugar-induced atrazine tolerance thus seemed to involve activation by sugar and atrazine of hexokinase-independent sugar signalling pathways and of ethylene signalling pathways, resulting in derepression of hexokinase-mediated Glc repression and in induction of protection mechanisms against atrazine injury.	Atrazine	14-22	hexokinase	Arabidopsis thaliana	92-102
17293001-7	2007	Sugar-induced atrazine tolerance thus seemed to involve activation by sugar and atrazine of hexokinase-independent sugar signalling pathways and of ethylene signalling pathways, resulting in derepression of hexokinase-mediated Glc repression and in induction of protection mechanisms against atrazine injury.	Atrazine	14-22	hexokinase	Arabidopsis thaliana	207-217
17293001-7	2007	Sugar-induced atrazine tolerance thus seemed to involve activation by sugar and atrazine of hexokinase-independent sugar signalling pathways and of ethylene signalling pathways, resulting in derepression of hexokinase-mediated Glc repression and in induction of protection mechanisms against atrazine injury.	Atrazine	80-88	hexokinase	Arabidopsis thaliana	92-102
17520059-8	2007	RESULTS: Atrazine-responsive adrenal carcinoma cells (H295R) expressed 54 times more SF-1 than nonresponsive ovarian granulosa KGN cells.	Atrazine	9-17	splicing factor 1	Homo sapiens	85-89
17331471-0	2007	Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II.	Atrazine	10-18	splicing factor 1	Homo sapiens	29-33
17331471-2	2007	We recently reported that atrazine induces human aromatase gene expression via promoter II (ArPII) in a steroidogenic factor 1 (SF-1)-dependent manner.	Atrazine	26-34	splicing factor 1	Homo sapiens	104-132
17331471-3	2007	Here, we show that knockdown of SF-1 abolishes ArPII induction by atrazine in H295R cells, which harbor high SF-1 expression and are originally atrazine-responsive.	Atrazine	66-74	splicing factor 1	Homo sapiens	32-36
17331471-3	2007	Here, we show that knockdown of SF-1 abolishes ArPII induction by atrazine in H295R cells, which harbor high SF-1 expression and are originally atrazine-responsive.	Atrazine	144-152	splicing factor 1	Homo sapiens	32-36
17331471-4	2007	Conversely, exogenous SF-1 enables atrazine to induce ArPII in the otherwise non-responsive KGN cells.	Atrazine	35-43	splicing factor 1	Homo sapiens	22-26
17331471-5	2007	Atrazine"s effect is independent from protein kinase A and LRH-1, a close relative of SF-1.	Atrazine	0-8	splicing factor 1	Homo sapiens	86-90
17331471-7	2007	Intriguingly, LBD mutations do not alter SF-1"s ability to mediate atrazine stimulation, suggesting that atrazine interacts with SF-1 via a region(s) other than the ligand binding pocket.	Atrazine	105-113	splicing factor 1	Homo sapiens	129-133
17331471-8	2007	These data suggest that atrazine binds to and activates SF-1 to induce ArPII.	Atrazine	24-32	splicing factor 1	Homo sapiens	56-60
18607078-5	2007	The hGSTP1-1 showed very high specific activity toward atrazine.	Atrazine	55-63	glutathione S-transferase pi 1	Homo sapiens	4-12
17520059-10	2007	Atrazine induced binding of SF-1 to chromatin and mutation of the SF-1 binding site in ArPII eliminated SF-1 binding and atrazine-responsiveness in H295R cells.	Atrazine	121-129	splicing factor 1	Homo sapiens	66-70
17520059-12	2007	Atrazine bound directly to SF-1, showing that atrazine is a ligand for this "orphan" receptor.	Atrazine	0-8	splicing factor 1	Homo sapiens	27-31
17520059-12	2007	Atrazine bound directly to SF-1, showing that atrazine is a ligand for this "orphan" receptor.	Atrazine	46-54	splicing factor 1	Homo sapiens	27-31
17520059-0	2007	Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.	Atrazine	0-8	splicing factor 1	Homo sapiens	41-45
17520059-3	2007	METHODS: We compared steroidogenic factor 1 (SF-1) expression in atrazine responsive and non-responsive cell lines and transfected SF-1 into nonresponsive cell lines to assess SF-1"s role in atrazine-induced aromatase.	Atrazine	65-73	splicing factor 1	Homo sapiens	45-49
17520059-4	2007	We used a luciferase reporter driven by the SF-1-dependent aromatase promoter (ArPII) to examine activation of this promoter by atrazine and the related simazine.	Atrazine	128-136	splicing factor 1	Homo sapiens	44-48
17520059-7	2007	Finally, we examined the ability of atrazine and simazine to bind to SF-1 and enhance SF-1 binding to ArPII.	Atrazine	36-44	splicing factor 1	Homo sapiens	69-73
17520059-7	2007	Finally, we examined the ability of atrazine and simazine to bind to SF-1 and enhance SF-1 binding to ArPII.	Atrazine	36-44	splicing factor 1	Homo sapiens	86-90
17520059-9	2007	Exogenous SF-1 conveyed atrazine-responsiveness to otherwise nonresponsive KGN and NIH/3T3 cells.	Atrazine	24-32	splicing factor 1	Homo sapiens	10-14
17520059-10	2007	Atrazine induced binding of SF-1 to chromatin and mutation of the SF-1 binding site in ArPII eliminated SF-1 binding and atrazine-responsiveness in H295R cells.	Atrazine	0-8	splicing factor 1	Homo sapiens	28-32
17520059-10	2007	Atrazine induced binding of SF-1 to chromatin and mutation of the SF-1 binding site in ArPII eliminated SF-1 binding and atrazine-responsiveness in H295R cells.	Atrazine	121-129	splicing factor 1	Homo sapiens	66-70
17213623-6	2007	The binding amount of CAT to CAT-MIP was 24% more than atrazine and 72% more than propazine.	Atrazine	55-63	catalase	Homo sapiens	22-25
17213623-6	2007	The binding amount of CAT to CAT-MIP was 24% more than atrazine and 72% more than propazine.	Atrazine	55-63	catalase	Homo sapiens	29-32
17115404-5	2007	Field dissipation of atrazine followed first-order kinetics, and calculated half-life values for atrazine combined over 2003 and 2005 increased in the order of CC (9 d) = CCR (10 d) < NAH (17 d).	Atrazine	97-105	cinnamoyl CoA reductase 1	Zea mays	171-174
17115404-6	2007	Greenhouse studies confirmed that the persistence of atrazine was approximately twofold greater in NAH soil than in CC or CCR soil.	Atrazine	53-61	cinnamoyl CoA reductase 1	Zea mays	122-125
18958706-0	2006	Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine.	Atrazine	99-107	toll like receptor 3	Homo sapiens	37-41
17177535-0	2006	Metalloporphyrins as biomimetic models for cytochrome p-450 in the oxidation of atrazine.	Atrazine	80-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
17177535-1	2006	The aim of this work was to evaluate whether metalloporphyrin models could mimic the action of cytochrome P-450 in the oxidation of atrazine, a herbicide.	Atrazine	132-140	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-111
18958706-0	2006	Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine.	Atrazine	99-107	interleukin 6	Homo sapiens	50-54
18958706-6	2006	Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected.	Atrazine	73-81	interleukin 6	Homo sapiens	145-149
18958706-6	2006	Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected.	Atrazine	73-81	interleukin 10	Homo sapiens	217-222
18958706-8	2006	However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1).	Atrazine	76-84	interleukin 6	Homo sapiens	207-211
18958706-8	2006	However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1).	Atrazine	76-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	359-364
18958706-8	2006	However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1).	Atrazine	76-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	407-411
18958706-11	2006	Dieldrin and atrazine administered orally (as opposed to subcutaneously as in the other experiments) also effectively suppressed IL-6 production.	Atrazine	13-21	interleukin 6	Homo sapiens	129-133
16616295-5	2006	The sum of PCB congeners (mean 8.9 ng l(-1)) showed the highest concentrations among the organochlorine compounds and atrazine (mean 82 ng l(-1)) among the polar pesticides.	Atrazine	118-126	pyruvate carboxylase	Homo sapiens	11-14
16381660-5	2006	The atrazine-induced beta-hexosaminidase release was characterized by various inhibitors including antisense-oligodeoxynucleotide for Galpha(q/11), pertussis toxin, phospholipase C inhibitor U-73122, inositol 1,4,5-triphosphate receptor inhibitor xestospongin C and Ca(2+) channel blocker lanthanum chloride.	Atrazine	4-12	O-GlcNAcase	Rattus norvegicus	21-40
16397785-5	2006	Moreover, acquisition of sucrose protection was shown to unmask atrazine-induced gene expression, such as that of a cytosolic glutathione-S-transferase, which remained otherwise cryptic because of the lethal effects of atrazine in the absence of soluble sugars.	Atrazine	64-72	glutathione S-transferase F11	Arabidopsis thaliana	126-151
16397785-5	2006	Moreover, acquisition of sucrose protection was shown to unmask atrazine-induced gene expression, such as that of a cytosolic glutathione-S-transferase, which remained otherwise cryptic because of the lethal effects of atrazine in the absence of soluble sugars.	Atrazine	219-227	glutathione S-transferase F11	Arabidopsis thaliana	126-151
16608219-0	2006	Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19.	Atrazine	35-43	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	103-109
16608219-0	2006	Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19.	Atrazine	35-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-117
16608219-0	2006	Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19.	Atrazine	35-43	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	123-130
16876710-1	2006	The effect of xenobiotics (phenobarbital and atrazine) on the expression of Drosophila melanogaster CYP genes encoding cytochromes P450, a gene family generally associated with detoxification, was analyzed by DNA microarray hybridization and verified by real-time RT-PCR in adults of both sexes.	Atrazine	45-53	disembodied	Drosophila melanogaster	100-103
16876710-1	2006	The effect of xenobiotics (phenobarbital and atrazine) on the expression of Drosophila melanogaster CYP genes encoding cytochromes P450, a gene family generally associated with detoxification, was analyzed by DNA microarray hybridization and verified by real-time RT-PCR in adults of both sexes.	Atrazine	45-53	Cytochrome P450-6a8	Drosophila melanogaster	131-135
16876710-3	2006	Eleven CYP genes and three glutathione S-transferases (GST) genes were significantly induced by phenobarbital, seven CYP and one GST gene were induced by atrazine.	Atrazine	154-162	disembodied	Drosophila melanogaster	7-10
16876710-3	2006	Eleven CYP genes and three glutathione S-transferases (GST) genes were significantly induced by phenobarbital, seven CYP and one GST gene were induced by atrazine.	Atrazine	154-162	disembodied	Drosophila melanogaster	117-120
16248553-0	2005	Transgenic rice plants expressing human CYP1A1 remediate the triazine herbicides atrazine and simazine.	Atrazine	81-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-46
16428846-1	2006	In atrazine-tolerant tobacco cells with Ser to Thr mutation at the 264th amino acid of PsbA polypeptide in photosystem II (PSII), electron trannsport around the secondary quinone acceptor (Q(B)) site was inhibited to a greater extent by barbatic acid than in wild-type cells.	Atrazine	3-11	psbA	Nicotiana tabacum	87-91
16125751-7	2006	A secondary metabolite, methylated atrazine (M-ATR) not previously documented to be derived from atrazine, was chemically produced, detected in all sediments and time points, and concentrations were an order of magnitude higher than DEA.	Atrazine	35-43	ATR serine/threonine kinase	Homo sapiens	47-50
16125751-7	2006	A secondary metabolite, methylated atrazine (M-ATR) not previously documented to be derived from atrazine, was chemically produced, detected in all sediments and time points, and concentrations were an order of magnitude higher than DEA.	Atrazine	97-105	ATR serine/threonine kinase	Homo sapiens	47-50
16221967-5	2006	At the neuronal level, the neuropeptide somatostatin, specific for the secretion of growth hormone, seemed to be a major target of atrazine effects, as demonstrated by evident subtype2,3,5 receptor mRNA differences of this neuropeptide, at least for the first two subtypes.	Atrazine	131-139	growth hormone	Mus musculus	84-98
16332129-12	2005	NaSA increased atrazine activity on npr1-2, an Arabidopsis mutant compromised in SA-induced disease resistance.	Atrazine	15-23	regulatory protein (NPR1)	Arabidopsis thaliana	36-42
16248553-3	2005	One-month-old CYP1A1 plants grown in soil clearly showed a healthy growth and tolerance to 8.8 microM atrazine and 50 microM simazine, but nontransgenic plants were completely killed by the herbicides.	Atrazine	102-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
16248553-4	2005	Although transgenic and nontransgenic plants metabolized the two herbicides into the same sets of compounds, CYP1A1 plants metabolized atrazine and simazine more rapidly than did control plants.	Atrazine	135-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	109-115
16248553-5	2005	In small-scale experiments, residual amounts of atrazine and simazine in the culture medium of CYP1A1 plants were 43.4 and 12.3% of those in control medium; those of nontransgenic Nipponbare were 68.3 and 57.2%, respectively.	Atrazine	48-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
16248553-6	2005	When cultivated in soil with 2.95 microM atrazine and 3.15 microM simazine for 25 days, CYP1A1 plants eliminated 1.3 times more atrazine and 1.4 times more simazine from the soil than did control plants.	Atrazine	41-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
16248553-6	2005	When cultivated in soil with 2.95 microM atrazine and 3.15 microM simazine for 25 days, CYP1A1 plants eliminated 1.3 times more atrazine and 1.4 times more simazine from the soil than did control plants.	Atrazine	128-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
16248553-7	2005	Thus, CYP1A1 rice plants make it possible to remove atrazine and simazine more rapidly from the culture medium and soil than can nontransgenic Nipponbare.	Atrazine	52-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-12
15901915-0	2005	Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African clawed frogs (Xenopus laevis).	Atrazine	11-19	cytochrome P450 family 19 subfamily A member 1 L homeolog	Xenopus laevis	23-28
15926565-6	2005	Both air-dried-rehydrated and never-dried Ca-PC expanded to approximately 2.0 nm in 10 mM CaCl2 and both samples had similar affinities for atrazine that were slightly lower than that of never-dried K-PC.	Atrazine	140-148	structural maintenance of chromosomes 4	Homo sapiens	42-47
15910738-2	2005	This paper demonstrates a concentration-dependent relationship of C. elegans CYP35A1, A2, A5, and C1 gene expression in response to four organic xenobiotics, namely atrazine, PCB52, fluoranthene, and lansoprazole.	Atrazine	165-173	CYtochrome P450 family	Caenorhabditis elegans	77-84
15851416-7	2005	Definite proof that Ely is atrazine-resistant was obtained by sequencing the psbA gene, encoding the D1 protein of photosystem II, revealing a point mutation causing the same amino acid change as found in other atrazine-resistant species.	Atrazine	27-35	photosystem II protein D1	Arabidopsis thaliana	77-81
15851416-7	2005	Definite proof that Ely is atrazine-resistant was obtained by sequencing the psbA gene, encoding the D1 protein of photosystem II, revealing a point mutation causing the same amino acid change as found in other atrazine-resistant species.	Atrazine	211-219	photosystem II protein D1	Arabidopsis thaliana	77-81
15913015-6	2005	Growth of bacteria on the surface of WAC was observed during column study and bacterial activity enhanced the effectiveness of adsorbent on atrazine removal from wastewater.	Atrazine	140-148	WW domain containing adaptor with coiled-coil	Homo sapiens	37-40
15698646-5	2005	The parameter K10 obtained from this equation (adsorption capacity at an equilibrium solution concentration of atrazine equal to 10 mg l-1) shows clearly that the presence of 0.1 M KCl in the medium tends to increase the adsorption of atrazine in the range of temperature studied.	Atrazine	111-119	keratin 10	Homo sapiens	14-17
15698646-5	2005	The parameter K10 obtained from this equation (adsorption capacity at an equilibrium solution concentration of atrazine equal to 10 mg l-1) shows clearly that the presence of 0.1 M KCl in the medium tends to increase the adsorption of atrazine in the range of temperature studied.	Atrazine	235-243	keratin 10	Homo sapiens	14-17
15115887-5	2004	Using recombinant alpha, mu, pi and theta class human GSTs, we demonstrated that only hGSTP1-1 displays significant activity toward atrazine (7.1 nmol/min/mg protein).	Atrazine	132-140	glutathione S-transferase pi 1	Homo sapiens	86-94
15115887-6	2004	We also confirmed that mouse GST Pi (pi) protein is responsible for the GSH-dependent biotransformation of atrazine in mouse liver; recombinant mGSTP1-1 had a specific activity of 7.3-nmol/min/mg protein.	Atrazine	107-115	glutathione S-transferase, pi 1	Mus musculus	144-152
15115887-8	2004	Docking studies of the atrazine-GST conjugate in the hGSTP1-1 substrate-binding site were used to elucidate a basis for the dramatic difference in activity between mouse GSTP1-1 and GSTP2-2 (7.14 versus 0.02 nmol/min/mg protein, respectively).	Atrazine	23-31	glutathione S-transferase pi 1	Homo sapiens	53-59
15115887-8	2004	Docking studies of the atrazine-GST conjugate in the hGSTP1-1 substrate-binding site were used to elucidate a basis for the dramatic difference in activity between mouse GSTP1-1 and GSTP2-2 (7.14 versus 0.02 nmol/min/mg protein, respectively).	Atrazine	23-31	glutathione S-transferase, pi 1	Mus musculus	54-61
15115887-8	2004	Docking studies of the atrazine-GST conjugate in the hGSTP1-1 substrate-binding site were used to elucidate a basis for the dramatic difference in activity between mouse GSTP1-1 and GSTP2-2 (7.14 versus 0.02 nmol/min/mg protein, respectively).	Atrazine	23-31	glutathione S-transferase, pi 2	Mus musculus	182-189
15115887-12	2004	Overall, this work supports a physiological role for GSTs in atrazine biotransformation and indicates a novel diagnostic substrate for human and mouse GSTP1-1 proteins.	Atrazine	61-69	glutathione S-transferase kappa 1	Homo sapiens	53-57
18969441-0	2004	Conductometric tyrosinase biosensor for the detection of diuron, atrazine and its main metabolites.	Atrazine	65-73	tyrosinase	Homo sapiens	15-25
15056801-10	2004	Using an in vitro receptor binding assay, ATRA, but not DACT, inhibited binding of [(3)H]-estradiol to ER.	Atrazine	42-46	estrogen receptor 1	Rattus norvegicus	103-105
15056801-12	2004	Collectively, these results indicate that although ATRA is capable of binding ER in vitro, the suppression of LH after treatment with high doses of ATRA is not due to alterations of hypothalamic ER function.	Atrazine	51-55	estrogen receptor 1	Rattus norvegicus	78-80
15081833-11	2004	The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta.	Atrazine	174-182	estrogen receptor beta	Ictalurus punctatus	251-257
12875406-9	2003	The surface diffusion coefficients of atrazine and p-DCB were modeled as a function of the surface concentration of the pore-blocking compound, PSS-1.8k.	Atrazine	38-46	corneodesmosin	Homo sapiens	144-149
14962502-1	2004	Our studies suggested that prenatal exposure to the herbicide atrazine (ATR) could delay vaginal opening (VO) and mammary development in the offspring of Long-Evans (LE) rats.	Atrazine	62-70	ATR serine/threonine kinase	Rattus norvegicus	72-75
15137633-1	2004	The main effects of pollutions including acid rain, Cu2+, atrazine and their combined products on the activities of urease, invertin, acid phosphatase and catalase were studied by means of orthogonal test.	Atrazine	58-66	catalase	Homo sapiens	155-163
14727741-0	2004	Biotransformation of atrazine in transgenic tobacco cell culture expressing human P450.	Atrazine	21-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-86
14727741-6	2004	The results showed that both foreign enzymes CYP1A1 and CYP1A2 catalyse N-dealkylation of atrazine.	Atrazine	90-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
14727741-6	2004	The results showed that both foreign enzymes CYP1A1 and CYP1A2 catalyse N-dealkylation of atrazine.	Atrazine	90-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62
15139204-3	2004	Interaction analysis revealed that Cu x atrazine exhibited synergism on soil acid phosphatase activity, Cu x H had antagonism on soil invertase and urease, but atrazine x H had no interaction within the investigated concentration range.	Atrazine	40-48	cut like homeobox 1	Homo sapiens	35-39
19709256-8	2002	The atzA gene encodes the enzyme which catalyzes the first step of atrazine mineralization by the strain.	Atrazine	67-75	atzA	Pseudomonas sp. ADP	4-8
12531259-3	2003	The model compounds were found to affect atrazine adsorption through two different mechanisms due to their size difference: direct competition for sites by p-DCB and pore constriction/blockage by PSS-1.8k.	Atrazine	41-49	corneodesmosin	Homo sapiens	196-201
12531259-5	2003	In contrast, the effect of PSS-1.8k on atrazine adsorption capacity was very small.	Atrazine	39-47	corneodesmosin	Homo sapiens	27-32
12531259-7	2003	However, preloading PAC with PSS-1.8k lowered the atrazine surface diffusion coefficient, D(s), by more than three orders of magnitude; D(s) decreased with increasing solid phase PSS-1.8k concentration.	Atrazine	50-58	corneodesmosin	Homo sapiens	29-34
21782617-0	2002	Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine.	Atrazine	91-99	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	13-27
12146633-3	2002	The adsorption constant related soil organic carbon content (Koc) calculated from Freundlich equation were 314 for acetochlor, 133 for atrazine, 2805 for carbendazim, 1589 for diazinon, 210 for imidacloprid and 174 for isoproturon.	Atrazine	135-143	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	61-64
21782617-0	2002	Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine.	Atrazine	91-99	hematopoietic prostaglandin D synthase	Rattus norvegicus	29-54
21782617-0	2002	Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine.	Atrazine	91-99	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-74
21782617-2	2002	The P-gp content was increased after 24 h of atrazine administration at 50 mg/kg, and maximum P-gp induction was observed at 300 mg/kg for 3 days.	Atrazine	45-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	4-8
21782617-4	2002	Among the CYP families, CYP1A2 was highly and CYP2B was slightly induced by atrazine while the CYP3A content remained unchanged.	Atrazine	76-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	10-13
21782617-4	2002	Among the CYP families, CYP1A2 was highly and CYP2B was slightly induced by atrazine while the CYP3A content remained unchanged.	Atrazine	76-84	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	24-30
21782617-6	2002	The inductions of P-gp, GST-P and CYP1A2 observed may explain some of the reported tumor-promoting properties and toxicity of atrazine in vivo.	Atrazine	126-134	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	18-22
21782617-6	2002	The inductions of P-gp, GST-P and CYP1A2 observed may explain some of the reported tumor-promoting properties and toxicity of atrazine in vivo.	Atrazine	126-134	glutathione S-transferase pi 1	Rattus norvegicus	24-29
21782617-6	2002	The inductions of P-gp, GST-P and CYP1A2 observed may explain some of the reported tumor-promoting properties and toxicity of atrazine in vivo.	Atrazine	126-134	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	34-40
11695606-7	2001	Addition of C-18 resin as an "alternate sorbent" upon cooling increased recovery of PAHs but not of pesticides, however, it increased the stability of atrazine and propazine at higher temperatures.	Atrazine	151-159	Bardet-Biedl syndrome 9	Homo sapiens	12-16
11932494-1	2002	A three-dimensional model of the variable domain of the atrazine-specific Fab fragment K411B was constructed by molecular modeling using known structures of highly homologous immunoglobulins as templates.	Atrazine	56-64	FA complementation group B	Homo sapiens	74-77
11053540-1	2000	Since atrazine (ATR), a chlorotriazine herbicide, has been shown previously to alter the secretion of luteinizing hormone (LH) and prolactin (PRL) through a direct effect on the central nervous system (CNS), we hypothesized that exposure to ATR in the EDSTAC male pubertal protocol (juvenile to peripubertal) would alter the development of the male rat reproductive system.	Atrazine	6-14	prolactin	Rattus norvegicus	131-140
11453766-1	2001	The effect of surfactants on the biodegradation of trifluralin and atrazine (by Streptomyces PS1/5) and coumaphos (by degrading consortia from a contaminated cattle dip) in liquid cultures and soil slurries was tested at different concentrations of a rhamnolipid mixture (Rh-mix) and Triton X-100 (TX-100).	Atrazine	67-75	presenilin 1	Bos taurus	93-98
11590728-5	2001	substances in aqueous solution can facilitate atrazine hydrolysis; rate constants of atrazine hydrolysis with humic acid and NH4NO3 were 2.431 x 10(-3)/d and 1.498 x 10(-3)/d respectively which were 2.3 and 1.42 times of control (1.055 x 10(-3)/d); anion NO3- can inhibit catalysis of humic acid to atrazine hydrolysis.	Atrazine	46-54	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
11590728-5	2001	substances in aqueous solution can facilitate atrazine hydrolysis; rate constants of atrazine hydrolysis with humic acid and NH4NO3 were 2.431 x 10(-3)/d and 1.498 x 10(-3)/d respectively which were 2.3 and 1.42 times of control (1.055 x 10(-3)/d); anion NO3- can inhibit catalysis of humic acid to atrazine hydrolysis.	Atrazine	85-93	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
11590728-5	2001	substances in aqueous solution can facilitate atrazine hydrolysis; rate constants of atrazine hydrolysis with humic acid and NH4NO3 were 2.431 x 10(-3)/d and 1.498 x 10(-3)/d respectively which were 2.3 and 1.42 times of control (1.055 x 10(-3)/d); anion NO3- can inhibit catalysis of humic acid to atrazine hydrolysis.	Atrazine	85-93	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
11053540-1	2000	Since atrazine (ATR), a chlorotriazine herbicide, has been shown previously to alter the secretion of luteinizing hormone (LH) and prolactin (PRL) through a direct effect on the central nervous system (CNS), we hypothesized that exposure to ATR in the EDSTAC male pubertal protocol (juvenile to peripubertal) would alter the development of the male rat reproductive system.	Atrazine	16-19	prolactin	Rattus norvegicus	131-140
9920461-8	1998	Anti-rat CYP2B1 and CYP2E1 antibodies effectively inhibited DeiPr-ATZ, DeEt-ATZ and iPrOH-ATZ formations in both sexes.	Atrazine	66-69	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	9-15
10805241-11	2000	At the background site, dacthal (100%), atrazine (35%), cyanazine (22%), and the (primarily atrazine) triazine transformation products CIAT (35%) and CEAT (17%) were detected most frequently, suggesting their potential for long-range atmospheric transport.	Atrazine	92-100	sodium voltage-gated channel alpha subunit 8	Homo sapiens	135-139
11010866-1	2000	Bacterial atrazine catabolism is initiated by the enzyme atrazine chlorohydrolase (AtzA) in Pseudomonas sp.	Atrazine	10-18	atzA	Pseudomonas sp. ADP	57-81
11010866-1	2000	Bacterial atrazine catabolism is initiated by the enzyme atrazine chlorohydrolase (AtzA) in Pseudomonas sp.	Atrazine	10-18	atzA	Pseudomonas sp. ADP	83-87
11010866-7	2000	AtzA did not catalyze the hydrolysis of atrazine analogs containing the pseudohalide azido, methoxy, and cyano groups or thiomethyl and amino groups.	Atrazine	40-48	atzA	Pseudomonas sp. ADP	0-4
11010866-8	2000	Atrazine analogs with a chlorine substituent at carbon 2 and N-alkyl groups, ranging in size from methyl to t-butyl, all underwent dechlorination by AtzA.	Atrazine	0-8	atzA	Pseudomonas sp. ADP	149-153
11010866-14	2000	Cell extracts from Clavibacter michiganensis ATZ1, which also contains a gene homologous to atzA, were able to transform atrazine analogs containing pseudohalide and thiomethyl groups, in addition to the substrates used by AtzA from Pseudomonas sp.	Atrazine	121-129	atzA	Pseudomonas sp. ADP	92-96
11010866-14	2000	Cell extracts from Clavibacter michiganensis ATZ1, which also contains a gene homologous to atzA, were able to transform atrazine analogs containing pseudohalide and thiomethyl groups, in addition to the substrates used by AtzA from Pseudomonas sp.	Atrazine	121-129	atzA	Pseudomonas sp. ADP	223-227
11129571-1	2000	Among 11 isoforms of the human cytochrome P450 enzymes metabolizing xenobiotics, CYP 1A1 and CYP 1A2 were major P450 species in the metabolism of the herbicides chlortoluron and atrazine in a yeast expression system.	Atrazine	178-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-88
11129571-1	2000	Among 11 isoforms of the human cytochrome P450 enzymes metabolizing xenobiotics, CYP 1A1 and CYP 1A2 were major P450 species in the metabolism of the herbicides chlortoluron and atrazine in a yeast expression system.	Atrazine	178-186	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-100
10910990-6	2000	53, 297-307) that atrazine disrupts ovarian function by altering hypothalamic catecholamine concentrations and subsequently the regulation of luteinizing hormone (LH) and prolactin (PRL) secretion by the pituitary.	Atrazine	18-26	prolactin	Rattus norvegicus	171-180
10910990-16	2000	These data indicate that both atrazine and simazine inhibit the cellular synthesis of DA mediated by the tyrosine hydroxylase (TH), and NE mediated by dopamine beta-hydroxylase (DbetaH), and, as a result, there is a partial or significant inhibition of NE release.	Atrazine	30-38	dopamine beta-hydroxylase	Rattus norvegicus	151-176
10665386-3	2000	14C Ring-labelled atrazine was applied in a mixture with the commercial product Gesaprim 500 (Novartis) at a rate of 3 kg ha-1.	Atrazine	18-26	Rho GTPase activating protein 45	Homo sapiens	122-126
10746939-5	2000	In this report we demonstrated that the commonly used 2-chloro-s-triazine herbicides atrazine, simazine, and propazine dose-dependently (0-30 microM) induced aromatase (CYP19) activity to an apparent maximum of about 2.5-fold in H295R cells.	Atrazine	85-93	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	169-174
10568700-0	1999	Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring.	Atrazine	21-29	prolactin	Rattus norvegicus	75-84
10568700-4	1999	To test this hypothesis, suckling-induced PRL release was measured in Wistar dams treated twice daily with the herbicide atrazine (ATR, by gavage, on PND 1-4 at 0, 6.25, 12.5, 25, and 50 mg/kg body weight), or twice daily with the dopamine receptor agonist bromocriptine (BROM, sc, at 0.052, 0.104, 0.208, and 0.417 mg/kg); BROM is known to suppress PRL release.	Atrazine	121-129	ATR serine/threonine kinase	Rattus norvegicus	131-134
10568700-5	1999	Similarly, atrazine has also been reported to suppress PRL in adult females.	Atrazine	11-19	prolactin	Rattus norvegicus	55-58
10347888-1	1999	A peptidoglycan-associated lipoprotein (PAL) fused to an antibody fragment (scFv) specific to the herbicide and environmental pollutant atrazine, has been successfully targeted to the cell surface of Escherichia coli.	Atrazine	136-144	immunglobulin heavy chain variable region	Homo sapiens	76-80
9920461-8	1998	Anti-rat CYP2B1 and CYP2E1 antibodies effectively inhibited DeiPr-ATZ, DeEt-ATZ and iPrOH-ATZ formations in both sexes.	Atrazine	66-69	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	20-26
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	64-67	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	28-34
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	64-67	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	45-51
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	162-165	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	28-34
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	162-165	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	45-51
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	162-165	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	83-89
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	162-165	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	108-114
9920461-13	1998	These results may mean that CYP2B2, CYP2C11, CYP2D1 (only iPrOH-ATZ formation) and CYP2E1 in male rats, and CYP2B2, CYP2D1 and CYP2E1 in female rats are involved ATZ metabolism in liver, and that the substrate specificity of P450 isoforms for ATZ is broad.	Atrazine	162-165	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	127-133
9711812-0	1998	Changes in rat liver cytochrome P450 enzymes by atrazine and simazine treatment.	Atrazine	48-56	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-36
9711812-2	1998	We examined the effect of two chloro-s-triazines (atrazine and simazine) on hepatic microsomal cytochrome P450 enzymes in rat.	Atrazine	50-58	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	95-110
9711812-5	1998	Among the P450-dependent monooxygenase activities, testosterone 2 alpha-hydroxylase (T2AH) activity in rat, which is associated with CYP2C11, was significantly decreased at all doses of atrazine and simazine.	Atrazine	186-194	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	133-140
9537398-2	1998	Here, we show that five geographically distinct atrazine-degrading bacteria contain genes homologous to atzA, -B, and -C. The sequence identities of the atz genes from different atrazine-degrading bacteria were greater than 99% in all pairwise comparisons.	Atrazine	48-56	atzA	Pseudomonas sp. ADP	104-108
9537398-2	1998	Here, we show that five geographically distinct atrazine-degrading bacteria contain genes homologous to atzA, -B, and -C. The sequence identities of the atz genes from different atrazine-degrading bacteria were greater than 99% in all pairwise comparisons.	Atrazine	178-186	atzA	Pseudomonas sp. ADP	104-108
9486943-0	1997	p53 protein expression in peripheral lymphocytes from atrazine chronically intoxicated rats.	Atrazine	54-62	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
9422605-0	1998	AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes.	Atrazine	90-98	AtzC	Pseudomonas sp. ADP	0-4
9422605-2	1998	strain ADP metabolizes atrazine to cyanuric acid via three plasmid-encoded enzymes, AtzA, AtzB, and AtzC.	Atrazine	23-31	AtzC	Pseudomonas sp. ADP	100-104
9422605-5	1998	In this study, the third gene in the atrazine catabolic pathway, atzC, was cloned from a Pseudomonas sp.	Atrazine	37-45	AtzC	Pseudomonas sp. ADP	65-69
9422605-15	1998	Overall, the data suggest that AtzA, AtzB, and AtzC diverged from a common ancestor and, by random events, have been reconstituted onto an atrazine catabolic plasmid.	Atrazine	139-147	AtzC	Pseudomonas sp. ADP	47-51
10076835-8	1998	The resulting detection limits for atrazine in plasma and water samples using this clean-up and trace enrichment procedure were found to be 2 ng ml-1 and 20 pg ml-1 respectively.	Atrazine	35-43	interleukin 17F	Homo sapiens	145-156
9486943-1	1997	The p53 expression in peripheral lymphocytes of rats chronically exposed to atrazine was investigated.	Atrazine	76-84	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
9486943-5	1997	The results indicate that in the atrazine long-term administration, the serum level of atrazine is associated with: (i) Significantly increased percentage of lymphocytes expressing p53 protein for all treated animals; (ii) different p53 intracellular compartmentalization (nucleus and cytoplasm), depending on dose and time of atrazine administration.	Atrazine	33-41	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	233-236
9486943-5	1997	The results indicate that in the atrazine long-term administration, the serum level of atrazine is associated with: (i) Significantly increased percentage of lymphocytes expressing p53 protein for all treated animals; (ii) different p53 intracellular compartmentalization (nucleus and cytoplasm), depending on dose and time of atrazine administration.	Atrazine	87-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	181-184
9486943-5	1997	The results indicate that in the atrazine long-term administration, the serum level of atrazine is associated with: (i) Significantly increased percentage of lymphocytes expressing p53 protein for all treated animals; (ii) different p53 intracellular compartmentalization (nucleus and cytoplasm), depending on dose and time of atrazine administration.	Atrazine	87-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	233-236
9486943-5	1997	The results indicate that in the atrazine long-term administration, the serum level of atrazine is associated with: (i) Significantly increased percentage of lymphocytes expressing p53 protein for all treated animals; (ii) different p53 intracellular compartmentalization (nucleus and cytoplasm), depending on dose and time of atrazine administration.	Atrazine	87-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	181-184
9486943-5	1997	The results indicate that in the atrazine long-term administration, the serum level of atrazine is associated with: (i) Significantly increased percentage of lymphocytes expressing p53 protein for all treated animals; (ii) different p53 intracellular compartmentalization (nucleus and cytoplasm), depending on dose and time of atrazine administration.	Atrazine	87-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	233-236
9486943-6	1997	The present study suggests that atrazine modifies the p53 expression, which could confirm the clastogenicity of this herbicide, and that the detection of the p53 protein may serve as a biomarker for the long-term exposure to atrazine.	Atrazine	32-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	54-57
9486943-6	1997	The present study suggests that atrazine modifies the p53 expression, which could confirm the clastogenicity of this herbicide, and that the detection of the p53 protein may serve as a biomarker for the long-term exposure to atrazine.	Atrazine	225-233	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	158-161
8759853-17	1996	Our results indicate that AtzA is a novel atrazine-dechlorinating enzyme with fairly restricted substrate specificity and contributes to the microbial hydrolysis of atrazine to hydroxyatrazine in soils and groundwater.	Atrazine	42-50	atzA	Pseudomonas sp. ADP	26-30
9171990-7	1997	Methoxychlor, p,p"-DDT, atrazine, and nonylphenol reduced [3H]5 alpha-DHT binding to ABP by approximately 40%.	Atrazine	24-32	sex hormone binding globulin	Homo sapiens	85-88
8921635-0	1996	Partial molecular analysis of the psbA gene in Euglena gracilis mutants exhibiting resistance to DCMU and atrazine.	Atrazine	106-114	psbA	Euglena gracilis	34-38
8759853-8	1996	In this study, sequence analysis of the 1.9-kb AvaI fragment indicated that a single open reading frame, atzA, encoded an activity transforming atrazine to hydroxyatrazine.	Atrazine	144-152	atzA	Pseudomonas sp. ADP	105-109
8759853-16	1996	AtzA catalyzes the dechlorination of atrazine, simazine, and desethylatrazine but is not active with melamine, terbutylazine, or desethyldesisopropylatrazine.	Atrazine	37-45	atzA	Pseudomonas sp. ADP	0-4
9055410-7	1997	In this study, we show that this fragment also contained the second gene of the atrazine metabolic pathway, atzB.	Atrazine	80-88	atzB	Pseudomonas sp. ADP	108-112
9055410-16	1997	The atzA and atzB genes catalyze the first two steps of the metabolic pathway in a bacterium that rapidly metabolizes atrazine to carbon dioxide, ammonia, and chloride.	Atrazine	118-126	atzB	Pseudomonas sp. ADP	13-17
8759853-17	1996	Our results indicate that AtzA is a novel atrazine-dechlorinating enzyme with fairly restricted substrate specificity and contributes to the microbial hydrolysis of atrazine to hydroxyatrazine in soils and groundwater.	Atrazine	165-173	atzA	Pseudomonas sp. ADP	26-30
8812239-2	1996	Animals that were dosed with 50, 150, or 300 mg/kg of atrazine or simazine alone for 3 consecutive days did not exhibit any significant increases in uterine wet weight while decreases in cytosolic progesterone receptor (PR) binding levels and uterine peroxidase activity were observed.	Atrazine	54-62	progesterone receptor	Homo sapiens	197-218
8882805-5	1996	An experiment was also conducted to assess the ability of Streptomyces (strain PS1/5) to metabolize atrazine contaminated soil.	Atrazine	100-108	presenilin 1	Homo sapiens	79-84
33766575-3	2021	Here we reported that adult BalB/c mice exposed to atrazine (50 mg kg-1 body weight) by gavage for three consecutive days have reduced numbers of 3beta-hydroxysteroid dehydrogenase positive Leydig cells (LCs), associated with increased in situ cell death fluorescence and caspase-3 immuno-expression in the testes.	Atrazine	51-59	caspase 3	Mus musculus	272-281
7749601-1	1995	The hepatic cytosolic glutathione S-transferase (GST) activity in four strains of the mouse and one strain of the rat was studied with the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethachrynic acid (ETHA), cumene hydroperoxide (CU) and atrazine as the in vitro substrates.	Atrazine	277-285	hematopoietic prostaglandin D synthase	Mus musculus	22-47
7749601-1	1995	The hepatic cytosolic glutathione S-transferase (GST) activity in four strains of the mouse and one strain of the rat was studied with the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethachrynic acid (ETHA), cumene hydroperoxide (CU) and atrazine as the in vitro substrates.	Atrazine	277-285	hematopoietic prostaglandin D synthase	Mus musculus	49-52
7749601-2	1995	In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate.	Atrazine	106-114	hematopoietic prostaglandin D synthase	Mus musculus	76-79
7749601-2	1995	In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate.	Atrazine	106-114	CD1 antigen complex	Mus musculus	190-194
7749601-2	1995	In the mouse, significant gender, strain and age-related differences in the GST activity towards CDNB and atrazine were found between adolescent and sexually mature males and females of the CD-1, C57BL/6, DBA/2 and Swiss-Webster strains, and the differences were larger with atrazine as the substrate.	Atrazine	275-283	hematopoietic prostaglandin D synthase	Mus musculus	76-79
7749601-5	1995	The herbicide atrazine seems to be a useful substrate in the study of strain and age-related differences in the mouse GST class Pi.	Atrazine	14-22	hematopoietic prostaglandin D synthase	Mus musculus	118-121
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	Atrazine	27-35	progesterone receptor	Rattus norvegicus	91-112
8022941-1	1993	A mutation of the psbA gene was identified in photoautotrophic potato (Solanum tuberosum L. cv Superior x U.S. Department of Agriculture line 66-142) cells selected for resistance to 6-chloro-N-ethyl-N"-(1-methylethyl)-1,3,5-triazine-2,4-diamine (atrazine).	Atrazine	183-245	photosystem II protein D1	Solanum tuberosum	18-22
8022941-1	1993	A mutation of the psbA gene was identified in photoautotrophic potato (Solanum tuberosum L. cv Superior x U.S. Department of Agriculture line 66-142) cells selected for resistance to 6-chloro-N-ethyl-N"-(1-methylethyl)-1,3,5-triazine-2,4-diamine (atrazine).	Atrazine	247-255	photosystem II protein D1	Solanum tuberosum	18-22
8022941-4	1993	Atrazine resistance in selected cells was attributable to a mutation from AGT (serine) to ACT (threonine) in codon 264 of the psbA gene that encodes the QB protein.	Atrazine	0-8	photosystem II protein D1	Solanum tuberosum	126-130
8212068-3	1993	The administration of carbon tetrachloride (CCl4) to atrazine pretreated rats did not substantially augment the impairment of drug metabolizing enzymes brought about by CCl4 alone.	Atrazine	53-61	C-C motif chemokine ligand 4	Rattus norvegicus	44-48
8212068-4	1993	Results suggest that atrazine behaves like a relatively weak inducer of phenobarbital-inducible families of cytochrome P-450.	Atrazine	21-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	108-124
24196736-4	1990	The best results were observed with the atrazine analogue ametryn sulfoxide, which was coupled to bovine serum albumin for immunization and to Sepharose for immunoaffinity chromatography.	Atrazine	40-48	albumin	Oryctolagus cuniculus	105-118
33766575-6	2021	Similarly, LCs isolated from the testes of BalB/c mice that were exposed to atrazine (0.5, 25, 50 mg kg-1 body weight) in the same manner as in the first experiment presented dose-dependent increased caspase-3 activity, decreased cell viability, intratesticular and serum testosterone concentrations and LCs testosterone secretion.	Atrazine	76-84	caspase 3	Mus musculus	200-209
34791862-0	2021	Atrazine Inhalation Worsen Pulmonary Fibrosis Regulating the Nuclear Factor-Erythroid 2-Related Factor (Nrf2) Pathways Inducing Brain Comorbidities.	Atrazine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-102
34624533-0	2021	The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation.	Atrazine	52-60	Kelch-like ECH-associated protein 1	Rattus norvegicus	4-9
34624533-0	2021	The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation.	Atrazine	52-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	10-14
18092879-7	2008	The determined smallest transcript levels of psaB, psbC, and rbcL, which occurred at the highest atrazine concentration tested (400 mug/L), were only 34.6, 34.6, and 8.1%, respectively, of the control sample value.	Atrazine	97-105	photosystem I P700 chlorophyll a apoprotein A2	Chlorella vulgaris	45-49
18092879-7	2008	The determined smallest transcript levels of psaB, psbC, and rbcL, which occurred at the highest atrazine concentration tested (400 mug/L), were only 34.6, 34.6, and 8.1%, respectively, of the control sample value.	Atrazine	97-105	photosystem II 44 kDa protein	Chlorella vulgaris	51-55
18092879-7	2008	The determined smallest transcript levels of psaB, psbC, and rbcL, which occurred at the highest atrazine concentration tested (400 mug/L), were only 34.6, 34.6, and 8.1%, respectively, of the control sample value.	Atrazine	97-105	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlorella vulgaris	61-65
34791862-0	2021	Atrazine Inhalation Worsen Pulmonary Fibrosis Regulating the Nuclear Factor-Erythroid 2-Related Factor (Nrf2) Pathways Inducing Brain Comorbidities.	Atrazine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
34069982-11	2021	The SOD, CAT, GPx, cortisol, and glucose levels were increased in ATZ-exposed fish and reduced by fucoidan (p < 0.05).	Atrazine	66-69	catalase	Oreochromis niloticus	9-12
34119736-1	2021	The oxidative degradation of atrazine (ATR) using bimetallic Bi/Fe0 nanoparticles cooperated with citric acid (CA) and sodium citrate (NaCA) without extra addition of H2O2 or another oxidant was conducted.	Atrazine	29-37	nascent polypeptide associated complex subunit alpha	Homo sapiens	135-139
34589629-3	2021	Atrazine with the highest LD50 (4.23 mug mL-1) was less toxic than the other tested triazine herbicides Chloroacetanilides tested were more toxic than tested triazines, with LD50 0.08-1.42 mug mL-1 vs 1.44-4.23 mug mL-1, respectively.	Atrazine	0-8	L1 cell adhesion molecule	Mus musculus	41-45
34589629-3	2021	Atrazine with the highest LD50 (4.23 mug mL-1) was less toxic than the other tested triazine herbicides Chloroacetanilides tested were more toxic than tested triazines, with LD50 0.08-1.42 mug mL-1 vs 1.44-4.23 mug mL-1, respectively.	Atrazine	0-8	L1 cell adhesion molecule	Mus musculus	193-197
34589629-3	2021	Atrazine with the highest LD50 (4.23 mug mL-1) was less toxic than the other tested triazine herbicides Chloroacetanilides tested were more toxic than tested triazines, with LD50 0.08-1.42 mug mL-1 vs 1.44-4.23 mug mL-1, respectively.	Atrazine	0-8	L1 cell adhesion molecule	Mus musculus	215-219
34369487-5	2021	The method was also used for an internal standard calibration for the analysis of atrazine, which resulted in a LOD of 0.74 ng mL-1.	Atrazine	82-90	L1 cell adhesion molecule	Mus musculus	127-131
34146662-7	2021	Also, atrazine blocked the NSC cell cycle G1 phase via down-regulating CCND1, CDK2, and CDK4, with no obvious effect on apoptosis.	Atrazine	6-14	cyclin D1	Homo sapiens	71-76
34146662-7	2021	Also, atrazine blocked the NSC cell cycle G1 phase via down-regulating CCND1, CDK2, and CDK4, with no obvious effect on apoptosis.	Atrazine	6-14	cyclin dependent kinase 2	Homo sapiens	78-82
34146662-7	2021	Also, atrazine blocked the NSC cell cycle G1 phase via down-regulating CCND1, CDK2, and CDK4, with no obvious effect on apoptosis.	Atrazine	6-14	cyclin dependent kinase 4	Homo sapiens	88-92
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	paired box 6	Homo sapiens	44-48
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	tubulin beta 3 class III	Homo sapiens	50-55
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	neural cell adhesion molecule 1	Homo sapiens	57-62
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	glial fibrillary acidic protein	Homo sapiens	64-68
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	nuclear receptor subfamily 4 group A member 1	Homo sapiens	74-79
34146662-9	2021	Atrazine altered genes expression levels of PAX6, TUBB3, NCAM1, GFAP, TH, NR4A1, and GRIA1.	Atrazine	0-8	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	85-90
34547448-7	2021	While atrazine and ibuprofen increased ERK1/2 activity by ~2-fold in HepG2, they did not initiate an appreciable response in RTL-W1.	Atrazine	6-14	mitogen-activated protein kinase 3	Homo sapiens	39-45
34335472-0	2021	The Herbicide Atrazine Potentiates Angiotensin II-Induced Aldosterone Synthesis and Release From Adrenal Cells.	Atrazine	14-22	angiotensinogen	Homo sapiens	35-49
34335472-5	2021	Both atrazine and stressed animals displayed reduced adrenocortical zona glomerulosa thickness and aldosterone synthase (CYP11B2) expression, indicative of repeated adrenal stimulation by adrenocorticotropic hormone.	Atrazine	5-13	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	99-119
34335472-5	2021	Both atrazine and stressed animals displayed reduced adrenocortical zona glomerulosa thickness and aldosterone synthase (CYP11B2) expression, indicative of repeated adrenal stimulation by adrenocorticotropic hormone.	Atrazine	5-13	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	121-128
34435054-8	2021	To further illustrate the underlying mechanisms governing the effect of ATZ on EOC, real-time PCR and Western blotting were employed to assess the transcription and the expression level of Stat3 signaling pathway-related genes in Skov3 and MC3T3-E1 cells.	Atrazine	72-75	signal transducer and activator of transcription 3	Homo sapiens	189-194
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	signal transducer and activator of transcription 3	Homo sapiens	249-254
34435054-15	2021	Conclusions: The results of this study suggest that ATZ effectively promotes the proliferation and metastasis of EOC cells through the Stat3 signaling pathway by inducing low levels of ROS.	Atrazine	52-55	signal transducer and activator of transcription 3	Mus musculus	135-140
35334325-3	2022	Under the opted conditions, the linearity was in the range of 1.0-1000.0 ng mL-1 for atrazine and ametryn, 3.0-1500.0 ng mL-1 for tribenuron-methyl, metribuzin, profenofos and chlorpyrifos, 5.0 to 1500.0 ng mL-1 for phosalone, and 5.0-2000.0 ng mL-1 for malation with coefficient of determination (r2) >= 0.9943.	Atrazine	85-93	L1 cell adhesion molecule	Mus musculus	76-80
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	tumor protein p53	Homo sapiens	41-44
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	H3 histone pseudogene 16	Homo sapiens	49-52
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	vascular endothelial growth factor A	Homo sapiens	98-132
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	vascular endothelial growth factor A	Homo sapiens	134-138
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	matrix metallopeptidase 2	Homo sapiens	141-166
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	matrix metallopeptidase 2	Homo sapiens	168-172
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	matrix metallopeptidase 9	Homo sapiens	175-179
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	signal transducer and activator of transcription 3	Homo sapiens	181-233
34435054-11	2021	In Skov3 cells, the expression levels of p53 and p21 were downregulated, while those of Cyclin E, vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2), MMP9, signal transducers and activators of transcription 3 (Stat3), and p-Stat3 were upregulated by ATZ treatment.	Atrazine	275-278	signal transducer and activator of transcription 3	Homo sapiens	235-240
35437774-2	2022	ATZ challenge diminished luteinizing hormone, follicular stimulating hormone, testosterone and myeloperoxidase enzyme activity, but these effects were attenuated on co-treatment with CUR and QUE.	Atrazine	0-3	myeloperoxidase	Rattus norvegicus	95-110
34994930-8	2022	Moreover, degeneration of cells, cytoplasmic vacuolation, congestion of blood vessels, a strong immune reaction to caspase 3, and negligible immune expression of a glial fibrillary acidic protein (GFAP) were also noticed in the ATZ-treated group.	Atrazine	228-231	glial fibrillary acidic protein	Rattus norvegicus	164-195
35260874-4	2022	Herein, this study found that atrazine could induce oxidative stress and the expression of Nfkb and IRF1 in spleen, promoting the ox-mtDNA formation.	Atrazine	30-38	interferon regulatory factor 1	Homo sapiens	100-104
35260874-6	2022	Lastly, atrazine induced pyroptosis in spleen, mediating the activation of Nlrp3 inflammasome.	Atrazine	8-16	NLR family pyrin domain containing 3	Homo sapiens	75-80
35119268-6	2022	However, in the absence of ATZ, H2O2 and O2 - are key intermediates and precursors for 1O2, whereas in the presence of ATZ, a different pathway was followed to produce O2 - and 1O2.	Atrazine	119-122	immunoglobulin kappa variable 1D-39	Homo sapiens	168-180
35204751-3	2022	To document the role of the ATM-dependent DSB repair and signaling after pesticide exposure, we applied six current pesticides of domestic and environmental interest (lindane, atrazine, glyphosate, permethrin, pentachlorophenol and thiabendazole) to human skin fibroblast and brain cells.	Atrazine	176-184	ATM serine/threonine kinase	Homo sapiens	28-31
3429762-7	1987	Activity of serum ALT and SAP increased approximately 60% and 200% respectively in rats given 600 mg atrazine/kg bw for 7 days.	Atrazine	101-109	amyloid P component, serum	Rattus norvegicus	26-29
3237212-0	1988	Selection of an atrazine-resistant tobacco cell line having a mutant psbA gene.	Atrazine	16-24	psbA	Nicotiana tabacum	69-73
35002408-12	2022	Meanwhile, fish exposed with ATZ had the worst SOD, CAT, GPx, and the highest MDA level compared to the other groups (p < 0.05).	Atrazine	29-32	catalase	Oreochromis niloticus	52-55
2485638-0	1989	[The nucleotide sequence of the chloroplast psbA gene from Solanum nigrum atrazine resistant biotype and its relevant analysis].	Atrazine	74-82	psbA	Solanum nigrum	44-48
2485638-1	1989	The psbA gene cloned in pSB135 from Solanum nigrum atrazine-resistant biotype was sequenced.	Atrazine	51-59	psbA	Solanum nigrum	4-8
2485638-3	1989	On the basis of the deduced amino acid sequences the secondary structure of the 32kD proteins encoded by the psbA genes were compared between atrazine-resistant and susceptible biotypes, and some indications from the protein structure comparison were discussed.	Atrazine	142-150	psbA	Solanum nigrum	109-113
16593905-1	1988	The chloroplast gene psbA codes for the photosynthetic quinone-binding membrane protein Q(B), which is the target of the herbicide atrazine.	Atrazine	131-139	psbA	Nicotiana tabacum	21-25
16593905-3	1988	The psbA gene from an atrazine-resistant biotype of Amaranthus hybridus has been modified by fusing its coding region to transcription-regulation and transit-peptide-encoding sequences of a bona fide nuclear gene.	Atrazine	22-30	psbA	Nicotiana tabacum	4-8
33960999-0	2021	AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance.	Atrazine	46-54	aquaporin 2	Mus musculus	0-4
6514581-0	1984	Chloroplast-coded atrazine resistance in Solanum nigrum: psbA loci from susceptible and resistant biotypes are isogenic except for a single codon change.	Atrazine	18-26	psbA	Solanum nigrum	57-61
6514581-2	1984	The psbA gene coding for this protein was cloned from Solanum nigrum atrazine-susceptible ("S") and atrazine-resistant ("R") biotypes.	Atrazine	69-77	psbA	Solanum nigrum	4-8
6514581-2	1984	The psbA gene coding for this protein was cloned from Solanum nigrum atrazine-susceptible ("S") and atrazine-resistant ("R") biotypes.	Atrazine	100-108	psbA	Solanum nigrum	4-8
6588393-0	1984	Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2.	Atrazine	50-58	carboxylesterase 1C	Rattus norvegicus	97-118
5543779-2	1971	The primary factor for atrazine selectivity in corn (Zea mays) is the activity of a soluble enzyme, glutathione S-transferase, which detoxifies atrazine by catalyzing the formation of an atrazine-glutathione conjugate (GS-atrazine).	Atrazine	23-31	glutathione S-transferase	Zea mays	100-125
5543779-2	1971	The primary factor for atrazine selectivity in corn (Zea mays) is the activity of a soluble enzyme, glutathione S-transferase, which detoxifies atrazine by catalyzing the formation of an atrazine-glutathione conjugate (GS-atrazine).	Atrazine	144-152	glutathione S-transferase	Zea mays	100-125
33979940-4	2021	Moreover, atrazine (0.001-0.1 mg/L) upregulated the expression levels of hsp-6::GFP and hsp-6/60 in nematodes, indicating the activation of mitochondrial unfolded protein response (mtUPR).	Atrazine	10-18	Heat shock protein hsp-6	Caenorhabditis elegans	73-78
33979940-4	2021	Moreover, atrazine (0.001-0.1 mg/L) upregulated the expression levels of hsp-6::GFP and hsp-6/60 in nematodes, indicating the activation of mitochondrial unfolded protein response (mtUPR).	Atrazine	10-18	Heat shock protein hsp-6	Caenorhabditis elegans	88-96
33979940-5	2021	On the contrary, atrazine (1-10 mg/L) downregulated the expression levels of hsp-6::GFP and hsp-6/60 in nematodes.	Atrazine	17-25	Heat shock protein hsp-6	Caenorhabditis elegans	77-82
33979940-5	2021	On the contrary, atrazine (1-10 mg/L) downregulated the expression levels of hsp-6::GFP and hsp-6/60 in nematodes.	Atrazine	17-25	Heat shock protein hsp-6	Caenorhabditis elegans	92-100
33979940-6	2021	Furthermore, mtUPR induction governed by the RNAi knockdown of atfs-1 could increase the vulnerability of nematodes against atrazine toxicity.	Atrazine	124-132	Stress activated transcription factor atfs-1	Caenorhabditis elegans	63-69
6382165-1	1984	The psbA gene from higher plants, which codes for the atrazine herbicide binding protein of photosystem II (QB protein), has been recently sequenced by various laboratories.	Atrazine	54-62	photosystem II protein D1	Zea mays	4-8
7232106-2	1980	Atrazine levels ranged from 0.06 microgram/liter to 3.12 microgram/liter and were correlated to NO3--N concentrations with a coefficient of r = +0.55.	Atrazine	0-8	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
594626-3	1977	The RIA of Tgl was applied as a screening test for the in vitro secretory activity of human thyroid cells under the influence of two herbicides of the heterocyclic group (Amitrol and Atrazin).	Atrazine	183-190	thyroglobulin	Homo sapiens	11-14
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Atrazine	12-20	acetylcholinesterase	Danio rerio	109-129
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Atrazine	12-20	acetylcholinesterase	Danio rerio	131-135
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Atrazine	22-25	acetylcholinesterase	Danio rerio	109-129
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Atrazine	22-25	acetylcholinesterase	Danio rerio	131-135
33960999-11	2021	These results suggested that AQP2 was a target of LYC and protected against ATR-induced renal ionic homeostasis disturbance.	Atrazine	76-79	aquaporin 2	Mus musculus	29-33
33463082-6	2021	The comparative study with an androgen receptor (AR) antagonist vinclozolin suggested that these effects of atrazine on male genital development may not be through antagonism of AR.	Atrazine	108-116	androgen receptor	Mus musculus	30-47
33247401-2	2021	It was found that Cd2+ caused a significant decrease in ATZ degradation and increased its half-life from 17-34 days to 30-57 days (p < 0.0001).	Atrazine	56-59	CD2 molecule	Homo sapiens	18-21
33848901-9	2021	The ratio of DEA to atrazine (DEA/ATR) increased from January to August, which indicated the progressive degradation process in the bay.	Atrazine	20-28	ATR serine/threonine kinase	Homo sapiens	34-37
33463082-7	2021	The results also revealed that atrazine exposure significantly reduced maternal serum testosterone levels, decreased AR nuclear translocation, and altered the expression levels of developmental gene networks in developing penis of mice.	Atrazine	31-39	androgen receptor	Mus musculus	117-119
33463082-8	2021	Atrazine exposure also affected the expression of insulin-like 3 (Insl3) and steroidogenic gene expression in developing reproductive tract.	Atrazine	0-8	insulin-like 3	Mus musculus	50-64
33463082-8	2021	Atrazine exposure also affected the expression of insulin-like 3 (Insl3) and steroidogenic gene expression in developing reproductive tract.	Atrazine	0-8	insulin-like 3	Mus musculus	66-71
33463082-10	2021	Our data also suggest that prenatal atrazine exposure can induce cryptorchidism in F1 mice, possibly through down regulation of Insl3.	Atrazine	36-44	insulin-like 3	Mus musculus	128-133
33728608-4	2021	An increase in the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and cholesterol (CHO) in the high-dose ATZ group was observed.	Atrazine	160-163	glutamic pyruvic transaminase, soluble	Mus musculus	28-52
33728608-4	2021	An increase in the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and cholesterol (CHO) in the high-dose ATZ group was observed.	Atrazine	160-163	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	60-86
33728608-6	2021	The serum interleukin-5(IL-5) level of mice and the number of plaque-forming cell (PFC) in spleen cells in the high-dose ATZ group decreased significantly while there was a significant increase of the serum immunoglobulin G (IgG) in the high-dose ATZ group when compared to the negative control group.	Atrazine	121-124	interleukin 5	Mus musculus	10-23
33728608-6	2021	The serum interleukin-5(IL-5) level of mice and the number of plaque-forming cell (PFC) in spleen cells in the high-dose ATZ group decreased significantly while there was a significant increase of the serum immunoglobulin G (IgG) in the high-dose ATZ group when compared to the negative control group.	Atrazine	121-124	interleukin 5	Mus musculus	24-28
33264997-3	2021	Herein, an ATR-SEIRAS platform has been successfully developed to in situ monitor the selective adsorption mechanism of small pollutant molecule atrazine (ATZ) on the aptasensor interface by characteristic N-H peak of ATZ for the first time.	Atrazine	145-153	ATR serine/threonine kinase	Homo sapiens	11-14
33264997-3	2021	Herein, an ATR-SEIRAS platform has been successfully developed to in situ monitor the selective adsorption mechanism of small pollutant molecule atrazine (ATZ) on the aptasensor interface by characteristic N-H peak of ATZ for the first time.	Atrazine	155-158	ATR serine/threonine kinase	Homo sapiens	11-14
33264997-4	2021	Based on the constructed ATR-SEIRAS platform, a thermodynamics model is established for the selective adsorption of ATZ on the aptasensor interface, described with Langmuir adsorption with a dissociation constant of 1.1 nM.	Atrazine	116-119	ATR serine/threonine kinase	Homo sapiens	25-28
33388526-0	2021	Identification and characterization of serum albumin covalent adduct formed with atrazine by liquid chromatography mass spectrometry.	Atrazine	81-89	albumin	Homo sapiens	39-52
33207434-4	2021	The synthesized adsorbent was tested by XRD, SEM, EDX, FT-IR and BET to confirm the successful synthesis as well as effectiveness for the adsorption of AZN.	Atrazine	152-155	delta/notch like EGF repeat containing	Homo sapiens	65-68
33388526-1	2021	The present study developed an analytical technique to investigate the possible covalent adduct formation of albumin with the herbicide atrazine, and to characterize the protein modifications in vitro using liquid chromatography separation coupled with high resolution time-of-flight mass spectrometry (LC-TOF-MS).	Atrazine	136-144	albumin	Homo sapiens	109-116
33388526-2	2021	Tandem mass spectrum analysis (MS/MS) with collision induced dissociation (CID) revealed the specific sites of rat, human and bovine serum albumin adduct with atrazine.	Atrazine	159-167	albumin	Bos taurus	133-146
33388526-6	2021	Our results confirmed that atrazine can directly react with Cys-34 of serum albumin and form covalent adducts without prior metabolism.	Atrazine	27-35	albumin	Bos taurus	76-83
32389187-8	2020	This leads to high sensitivity in our immunoassay with a limit of detection of 0.5 ng mL-1 defined by selecting an IC10 concentration, i.e., the analyte concentration at which 10% of the available Pd@Pt nanoparticle-labeled antibody is inhibited from binding to a plate coated with a bovine serum albumin-atrazine conjugate.	Atrazine	305-313	L1 cell adhesion molecule	Mus musculus	86-90
32217410-0	2020	A nationwide study of the occurrence and distribution of atrazine and its degradates in tap water and groundwater in China: Assessment of human exposure potential.	Atrazine	57-65	nuclear RNA export factor 1	Homo sapiens	88-91
32217410-5	2020	The predominant compounds of ATZs in tap water were ATZ and DEA, with a detection frequency of 99.5% and 98.0%, respectively, followed by ATZ-OH (87.3%), DACT (84.0%), and DIA (78.1%).	Atrazine	29-32	nuclear RNA export factor 1	Homo sapiens	37-40
32216303-8	2020	Two examples are chosen to demonstrate the synergy advantage in elucidation of metabolic mechanism of triphenyl phosphate and atrazine catalyzed by CYP, respectively, which shows the interplay between experiments and computations allows gaining greater insight than the isolated methods.	Atrazine	126-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-151
32389187-10	2020	Our tests at 5, 10, and 20 ng mL-1 yielded recoveries of 99 - 115%, offering strong supporting evidence that atrazine and other low molecular weight herbicides and pesticides can be detected using this immunoassay approach.	Atrazine	109-117	L1 cell adhesion molecule	Mus musculus	30-34
31874286-11	2020	AZ significantly increased cortisol response and reduced levels of immunoglobulin, lysozyme and complement activities in females and their offspring.	Atrazine	0-2	lysozyme	Danio rerio	83-91
32018111-4	2020	In silico modeling analysis revealed that the active ingredients of Spectracide  (atrazine, diquat dibromide, fluazifop-p-butyl, and dicamba) have significant binding affinity to the active site of CR enzyme, with atrazine having comparatively greater affinity.	Atrazine	82-90	Carbonyl reductase	Drosophila melanogaster	198-200
32018111-4	2020	In silico modeling analysis revealed that the active ingredients of Spectracide  (atrazine, diquat dibromide, fluazifop-p-butyl, and dicamba) have significant binding affinity to the active site of CR enzyme, with atrazine having comparatively greater affinity.	Atrazine	214-222	Carbonyl reductase	Drosophila melanogaster	198-200
32275662-8	2020	slc6a4a and htr1Aa mRNA transcript levels were found to correlate positively with anxiety levels in controls, but we found that this relationship was disrupted in the 0.3 ppb atrazine treatment group.	Atrazine	175-183	solute carrier family 6 member 4a	Danio rerio	0-7
32275662-8	2020	slc6a4a and htr1Aa mRNA transcript levels were found to correlate positively with anxiety levels in controls, but we found that this relationship was disrupted in the 0.3 ppb atrazine treatment group.	Atrazine	175-183	5-hydroxytryptamine (serotonin) receptor 1A a	Danio rerio	12-18
31869719-7	2020	SI attenuate ATR-induced oxidative stress (indicated by MDA accumulation and GSH depletion) and inflammatory damage (as evidenced by TNF-alpha and IL-6 elevation) in the substantia nigra.	Atrazine	13-16	tumor necrosis factor	Rattus norvegicus	133-142
31869719-7	2020	SI attenuate ATR-induced oxidative stress (indicated by MDA accumulation and GSH depletion) and inflammatory damage (as evidenced by TNF-alpha and IL-6 elevation) in the substantia nigra.	Atrazine	13-16	interleukin 6	Rattus norvegicus	147-151
31869719-8	2020	ATR increased expression of the pro-apoptotic factor Bax and reduced expression levels of the DA synthesis enzyme tyrosine hydroxylase (TH) and the anti-apoptotic factor Bcl-2 in the substantia nigra and striatum.	Atrazine	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	53-56
31869719-8	2020	ATR increased expression of the pro-apoptotic factor Bax and reduced expression levels of the DA synthesis enzyme tyrosine hydroxylase (TH) and the anti-apoptotic factor Bcl-2 in the substantia nigra and striatum.	Atrazine	0-3	BCL2, apoptosis regulator	Rattus norvegicus	170-175
31869719-10	2020	ATR also inhibited autophagy in the substantial nigra as evidenced by LC3-II and Beclin-1 downregulation and increased expression of p62, whereas SI pretreatment reversed these effects, indicating autophagy induction.	Atrazine	0-3	beclin 1	Rattus norvegicus	81-89
31869719-10	2020	ATR also inhibited autophagy in the substantial nigra as evidenced by LC3-II and Beclin-1 downregulation and increased expression of p62, whereas SI pretreatment reversed these effects, indicating autophagy induction.	Atrazine	0-3	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	133-136
31869719-11	2020	Furthermore, ATR increased the expression of mTOR and reduced the expression of phosphorylated S6 (p-S6) and BEX2 in the substantia nigra.	Atrazine	13-16	mechanistic target of rapamycin kinase	Rattus norvegicus	45-49
31869719-11	2020	Furthermore, ATR increased the expression of mTOR and reduced the expression of phosphorylated S6 (p-S6) and BEX2 in the substantia nigra.	Atrazine	13-16	brain expressed X-linked 2	Rattus norvegicus	109-113
31869719-12	2020	Collectively, these findings suggest that SI can prevent ATR-mediated degeneration of DAergic neurons by inducing autophagy through an mTOR-dependent signaling pathway.	Atrazine	57-60	mechanistic target of rapamycin kinase	Rattus norvegicus	135-139
31689476-1	2020	Atrazine (ATZ), a widely used agricultural pesticide and benzo[a]pyrene (BaP), a ubiquitous environmental human carcinogen can induce alterations of spermatogenesis.	Atrazine	0-8	prohibitin 2	Homo sapiens	73-76
31689476-1	2020	Atrazine (ATZ), a widely used agricultural pesticide and benzo[a]pyrene (BaP), a ubiquitous environmental human carcinogen can induce alterations of spermatogenesis.	Atrazine	10-13	prohibitin 2	Homo sapiens	73-76
31659708-8	2019	Moreover, upregulation of spleen Fas and caspase-III genes was recorded in ATR-exposed rabbits.	Atrazine	75-78	tumor necrosis factor receptor superfamily member 6	Oryctolagus cuniculus	33-36
31816757-8	2020	Atrazine, atrazine-desethyl and diuron were the main pollutants found with a maximum time-weighted concentration of 61 +- 3, 62 +- 24 and 127 +- 49 ng L-1 respectively.	Atrazine	0-8	immunoglobulin kappa variable 1-16	Homo sapiens	151-154
31816757-8	2020	Atrazine, atrazine-desethyl and diuron were the main pollutants found with a maximum time-weighted concentration of 61 +- 3, 62 +- 24 and 127 +- 49 ng L-1 respectively.	Atrazine	10-27	immunoglobulin kappa variable 1-16	Homo sapiens	151-154
31717666-7	2019	In contrast, combined exposure to atrazine and paraquat had detrimental synergistic effects on female longevity.	Atrazine	34-42	longevity	Drosophila melanogaster	102-111
31137533-5	2019	Inorganic anion experiments revealed that Cl-, HCO3-, and NO3- showed inhibitory effects on the degradation of ATZ by US/PMS, with Cl- contributing the strongest inhibitory effect while NO3- showed the weakest suppression effect.	Atrazine	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
31717666-0	2019	Effects of Dual Exposure to the Herbicides Atrazine and Paraquat on Adult Climbing Ability and Longevity in Drosophila melanogaster.	Atrazine	43-51	longevity	Drosophila melanogaster	95-104
31717666-3	2019	Atrazine and paraquat are two of the most widely used herbicides in the United States, and are individually known to increase oxidative damage, affect dopaminergic functioning, reduce longevity, and alter motor ability in non-target organisms.	Atrazine	0-8	longevity	Drosophila melanogaster	184-193
31717666-4	2019	We measured the effects of individual and combined exposure to low doses of atrazine and paraquat on climbing ability and longevity of Drosophila melanogaster.	Atrazine	76-84	longevity	Drosophila melanogaster	122-131
31717666-5	2019	Atrazine and paraquat interact to affect D. melanogaster climbing ability and longevity in different ways.	Atrazine	0-8	longevity	Drosophila melanogaster	78-87
31229795-6	2019	Using a label-free transduction, we have detected atrazine in fairly low concentrations, with the limit of detection being 0.9 zM and the sensitivity being 4.11 (muA/muM)/cm2, in a wide dynamic detection range varying from 1 zM to 1 muM.	Atrazine	50-58	latexin	Homo sapiens	166-169
31229795-6	2019	Using a label-free transduction, we have detected atrazine in fairly low concentrations, with the limit of detection being 0.9 zM and the sensitivity being 4.11 (muA/muM)/cm2, in a wide dynamic detection range varying from 1 zM to 1 muM.	Atrazine	50-58	latexin	Homo sapiens	233-236
31319158-6	2019	We show that oxidative stress-mediated c-Jun N-terminal kinase (JNK) signaling activation underlies insulin resistance in flies exposed to atrazine during their development while DDVP-mediated T1D involves activation of caspase-mediated cell death pathway.	Atrazine	139-147	basket	Drosophila melanogaster	39-62
31319158-6	2019	We show that oxidative stress-mediated c-Jun N-terminal kinase (JNK) signaling activation underlies insulin resistance in flies exposed to atrazine during their development while DDVP-mediated T1D involves activation of caspase-mediated cell death pathway.	Atrazine	139-147	basket	Drosophila melanogaster	64-67
31319158-6	2019	We show that oxidative stress-mediated c-Jun N-terminal kinase (JNK) signaling activation underlies insulin resistance in flies exposed to atrazine during their development while DDVP-mediated T1D involves activation of caspase-mediated cell death pathway.	Atrazine	139-147	Insulin-like receptor	Drosophila melanogaster	100-107
31319158-7	2019	Mitigation of oxidative stress through over-expression of SOD2 in atrazine (20mug/ml) exposed flies, revealed significantly decreased oxidative stress levels and reduced phosphorylation of JNK.	Atrazine	66-74	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	58-62
31319158-7	2019	Mitigation of oxidative stress through over-expression of SOD2 in atrazine (20mug/ml) exposed flies, revealed significantly decreased oxidative stress levels and reduced phosphorylation of JNK.	Atrazine	66-74	basket	Drosophila melanogaster	189-192
31319158-8	2019	Moreover, glucose and Akt phosphorylation levels in SOD2 over-expression flies exposed to atrazine were comparable to those in controls, suggesting restoration in insulin sensitivity.	Atrazine	90-98	Akt1	Drosophila melanogaster	22-25
31319158-8	2019	Moreover, glucose and Akt phosphorylation levels in SOD2 over-expression flies exposed to atrazine were comparable to those in controls, suggesting restoration in insulin sensitivity.	Atrazine	90-98	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	52-56
31319158-8	2019	Moreover, glucose and Akt phosphorylation levels in SOD2 over-expression flies exposed to atrazine were comparable to those in controls, suggesting restoration in insulin sensitivity.	Atrazine	90-98	Insulin-like receptor	Drosophila melanogaster	163-170
31077389-7	2019	Under the experimental conditions used, atrazine showed a linear dynamic range of 0.5 to 5.0 mug mL-1 , and from 5.0 to 70.00 mug mL-1 with relative standard deviations (RSD) from 1.91% to 9.41%.	Atrazine	40-48	L1 cell adhesion molecule	Mus musculus	97-101
31077389-7	2019	Under the experimental conditions used, atrazine showed a linear dynamic range of 0.5 to 5.0 mug mL-1 , and from 5.0 to 70.00 mug mL-1 with relative standard deviations (RSD) from 1.91% to 9.41%.	Atrazine	40-48	L1 cell adhesion molecule	Mus musculus	130-134
31121522-6	2019	ARGININE DECARBOXYLASE ADC1 and ADC2 paralogues, which encode the rate-limiting enzyme (EC 4.1.1.19) of the first step of polyamine biosynthesis, were strongly upregulated by sucrose treatment in the presence of atrazine.	Atrazine	212-220	arginine decarboxylase 1	Arabidopsis thaliana	23-27
31121522-6	2019	ARGININE DECARBOXYLASE ADC1 and ADC2 paralogues, which encode the rate-limiting enzyme (EC 4.1.1.19) of the first step of polyamine biosynthesis, were strongly upregulated by sucrose treatment in the presence of atrazine.	Atrazine	212-220	arginine decarboxylase 2	Arabidopsis thaliana	32-36
31686234-12	2019	The observed effects of atrazine in maize seedlings can be attributed to oxidative stress as revealed by an increase in H2O2 content and higher activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) enzymes in atrazine-treated seedlings.	Atrazine	24-32	peroxidase 1	Zea mays	158-168
31686234-12	2019	The observed effects of atrazine in maize seedlings can be attributed to oxidative stress as revealed by an increase in H2O2 content and higher activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) enzymes in atrazine-treated seedlings.	Atrazine	24-32	peroxidase 1	Zea mays	170-173
31273423-0	2019	Cytochrome P450 and Glutathione-S-Transferase Activity are Altered Following Environmentally Relevant Atrazine Exposures in Crayfish (Faxoniusvirilis).	Atrazine	102-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-45
31273423-3	2019	We examined sublethal effects of atrazine on the expression and activity of the detoxification enzymes cytochrome P450 (CYP450) and glutathione-S-transferase (GST) in crayfish.	Atrazine	33-41	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-118
31273423-3	2019	We examined sublethal effects of atrazine on the expression and activity of the detoxification enzymes cytochrome P450 (CYP450) and glutathione-S-transferase (GST) in crayfish.	Atrazine	33-41	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-126
31273423-3	2019	We examined sublethal effects of atrazine on the expression and activity of the detoxification enzymes cytochrome P450 (CYP450) and glutathione-S-transferase (GST) in crayfish.	Atrazine	33-41	glutathione S-transferase kappa 1	Homo sapiens	132-157
31273423-3	2019	We examined sublethal effects of atrazine on the expression and activity of the detoxification enzymes cytochrome P450 (CYP450) and glutathione-S-transferase (GST) in crayfish.	Atrazine	33-41	glutathione S-transferase kappa 1	Homo sapiens	159-162
31273423-6	2019	Atrazine exposure caused differential expression and activity of CYP450 and GST.	Atrazine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-71
31273423-6	2019	Atrazine exposure caused differential expression and activity of CYP450 and GST.	Atrazine	0-8	glutathione S-transferase kappa 1	Homo sapiens	76-79
31273423-8	2019	Further, GST activity significantly increased following a 2 day, 10 ppb exposure to atrazine and a 300 ppb atrazine exposure for all days tested.	Atrazine	84-92	glutathione S-transferase kappa 1	Homo sapiens	9-12
31273423-8	2019	Further, GST activity significantly increased following a 2 day, 10 ppb exposure to atrazine and a 300 ppb atrazine exposure for all days tested.	Atrazine	107-115	glutathione S-transferase kappa 1	Homo sapiens	9-12
31185338-0	2019	Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/alpha-synuclein axis in atrazine-induced Parkinson"s disease by peripheral blood and brain microRNA profiling.	Atrazine	102-110	brain-derived neurotrophic factor	Rattus norvegicus	44-77
31185338-0	2019	Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/alpha-synuclein axis in atrazine-induced Parkinson"s disease by peripheral blood and brain microRNA profiling.	Atrazine	102-110	synuclein alpha	Rattus norvegicus	78-93
31185338-1	2019	Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine; ATR) is widely used as an herbicide, and its accumulation in the environment is a health risk to humans; for instance, it has been shown to cause dopaminergic neurotoxicity.	Atrazine	0-8	ATR serine/threonine kinase	Homo sapiens	61-64
31185338-1	2019	Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine; ATR) is widely used as an herbicide, and its accumulation in the environment is a health risk to humans; for instance, it has been shown to cause dopaminergic neurotoxicity.	Atrazine	10-59	ATR serine/threonine kinase	Homo sapiens	61-64
31187311-0	2019	The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway.	Atrazine	24-32	discs large MAGUK scaffold protein 4	Rattus norvegicus	145-150
31187311-0	2019	The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway.	Atrazine	24-32	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	151-155
31297616-0	2019	Fluorometric atrazine assay based on the use of nitrogen-doped graphene quantum dots and on inhibition of the activity of tyrosinase.	Atrazine	13-21	tyrosinase	Homo sapiens	122-132
31297616-6	2019	On addition of atrazine, the catalytic activity of tyrosinase is inhibited.	Atrazine	15-23	tyrosinase	Homo sapiens	51-61
31297616-8	2019	The assay has a linear response in the 2.5-100 ng mL-1 atrazine concentration range, and the detection limit is 1.2 ng mL-1.	Atrazine	55-63	L1 cell adhesion molecule	Mus musculus	50-54
31297616-8	2019	The assay has a linear response in the 2.5-100 ng mL-1 atrazine concentration range, and the detection limit is 1.2 ng mL-1.	Atrazine	55-63	L1 cell adhesion molecule	Mus musculus	119-123
31297616-10	2019	Graphical abstract Schematic presentation of the fluorometric assay of atrazine detection based on tyrosinase-induced fluorescence (FL) quenching effect on the nitrogen-doped graphene quantum dots (N-GQDs) and inhibitory effect of atrazine on tyrosinase.	Atrazine	71-79	tyrosinase	Homo sapiens	99-109
31297616-10	2019	Graphical abstract Schematic presentation of the fluorometric assay of atrazine detection based on tyrosinase-induced fluorescence (FL) quenching effect on the nitrogen-doped graphene quantum dots (N-GQDs) and inhibitory effect of atrazine on tyrosinase.	Atrazine	71-79	tyrosinase	Homo sapiens	243-253
31297616-10	2019	Graphical abstract Schematic presentation of the fluorometric assay of atrazine detection based on tyrosinase-induced fluorescence (FL) quenching effect on the nitrogen-doped graphene quantum dots (N-GQDs) and inhibitory effect of atrazine on tyrosinase.	Atrazine	231-239	tyrosinase	Homo sapiens	99-109
30933813-5	2019	ATZ was systematically detected (100%), with a concentration range of 30-195 ng L-1 (median: 49 ng L-1) while DEA was in the range of 10-187 ng L-1 (median: 36 ng L-1).	Atrazine	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	80-83
30933813-5	2019	ATZ was systematically detected (100%), with a concentration range of 30-195 ng L-1 (median: 49 ng L-1) while DEA was in the range of 10-187 ng L-1 (median: 36 ng L-1).	Atrazine	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
30933813-5	2019	ATZ was systematically detected (100%), with a concentration range of 30-195 ng L-1 (median: 49 ng L-1) while DEA was in the range of 10-187 ng L-1 (median: 36 ng L-1).	Atrazine	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
30933813-5	2019	ATZ was systematically detected (100%), with a concentration range of 30-195 ng L-1 (median: 49 ng L-1) while DEA was in the range of 10-187 ng L-1 (median: 36 ng L-1).	Atrazine	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
30877919-0	2019	Atrazine or bisphenol A mediated negative modulation of mismatch repair gene, mlh1 leads to defective oogenesis and reduced female fertility in Drosophila melanogaster.	Atrazine	0-8	Mlh1	Drosophila melanogaster	78-82
30877919-1	2019	The study reports the effects of an herbicide (atrazine) and a plasticizer (Bisphenol A, BPA) on the transcriptional modulation of a mismatch repair gene (mlh1) and its adverse consequences on female fertility using Drosophila as a model.	Atrazine	47-55	Mlh1	Drosophila melanogaster	155-159
30877919-2	2019	Through a chemical screen, we show that exposure to atrazine or BPA significantly downregulates mlh1 and the exposed flies had reduced fertility with smaller ovaries having reduced number of mature oocytes and abnormal distribution of ovarian follicles with increased apoptosis in them.	Atrazine	52-60	Mlh1	Drosophila melanogaster	96-100
30877919-6	2019	Further, exposure of females having reduced Mlh1 levels (mlh1e00130/CyO) to atrazine or BPA caused severe defective phenotypes at a higher proportion than normal flies.	Atrazine	76-84	Mlh1	Drosophila melanogaster	44-48
30877919-6	2019	Further, exposure of females having reduced Mlh1 levels (mlh1e00130/CyO) to atrazine or BPA caused severe defective phenotypes at a higher proportion than normal flies.	Atrazine	76-84	Sulfonylurea receptor	Drosophila melanogaster	68-71
30877919-7	2019	Our findings reveal the critical role of mlh1 in atrazine and BPA mediated female reproductive toxicity, and opens up a possibility of toxicants affecting female fertility by modulating the MMR genes.	Atrazine	49-57	Mlh1	Drosophila melanogaster	41-45
31137533-5	2019	Inorganic anion experiments revealed that Cl-, HCO3-, and NO3- showed inhibitory effects on the degradation of ATZ by US/PMS, with Cl- contributing the strongest inhibitory effect while NO3- showed the weakest suppression effect.	Atrazine	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
30629250-5	2019	ELISpot analysis showed only a small, insignificant reduction in PspA-specific IgG producing splenocytes in atrazine-treated male offspring.	Atrazine	108-116	surfactant associated protein A1	Mus musculus	65-69
31097751-7	2019	Due to the high BET surface area and low band gap, the nanoparticles with 2.0 wt.% of Ag@Mg4Ta2O9 display the best photocatalyst efficiency for atrazine degradation.	Atrazine	144-152	delta/notch like EGF repeat containing	Homo sapiens	16-19
30580161-0	2019	The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats.	Atrazine	50-58	Eph receptor B1	Rattus norvegicus	8-11
30580161-0	2019	The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats.	Atrazine	50-58	cAMP responsive element binding protein 1	Rattus norvegicus	12-16
30629250-6	2019	Interestingly, upon ex vivo stimulation with anti-CD3 and anti-CD28 antibodies, significant decreases in interleukin (IL)-2, tumor necrosis factor-alpha, interferon-gamma, and IL-17A and a decreasing trend in IL-10 were observed in splenocytes from atrazine-exposed male, but not female mice.	Atrazine	249-257	CD28 antigen	Mus musculus	63-67
30707840-4	2019	Here, the mechanism governing atrazine adsorption in Zr6-based metal-organic frameworks (MOFs) has been thoroughly investigated by studying the effects of MOF linkers and topology on atrazine uptake capacity and uptake kinetics.	Atrazine	30-38	lysine acetyltransferase 8	Homo sapiens	89-92
30899828-10	2019	Ordinance No 2914/2011 from the Brazilian Ministry of Health establishes the acceptable limits for atrazine and methyl parathion as 9 mug L-1 and 2 mug L-1.	Atrazine	99-107	L1 cell adhesion molecule	Homo sapiens	138-147
30899828-10	2019	Ordinance No 2914/2011 from the Brazilian Ministry of Health establishes the acceptable limits for atrazine and methyl parathion as 9 mug L-1 and 2 mug L-1.	Atrazine	99-107	L1 cell adhesion molecule	Homo sapiens	138-141
30707840-4	2019	Here, the mechanism governing atrazine adsorption in Zr6-based metal-organic frameworks (MOFs) has been thoroughly investigated by studying the effects of MOF linkers and topology on atrazine uptake capacity and uptake kinetics.	Atrazine	183-191	lysine acetyltransferase 8	Homo sapiens	89-92
30707840-6	2019	Without the presence of a pyrene-based linker, NU-1008, a MOF similar to NU-1000 with respect to surface area and pore size, removed &lt;20% of the exposed atrazine.	Atrazine	156-164	lysine acetyltransferase 8	Homo sapiens	58-61
30707840-7	2019	These results suggest that the atrazine uptake capacity demonstrated by NU-1000 stems from the presence of a pyrene core in the MOF linker, affirming that pi-pi stacking is responsible for driving atrazine adsorption.	Atrazine	31-39	lysine acetyltransferase 8	Homo sapiens	128-131
29710542-10	2018	Testicular DNA laddering % and CYP17A1 mRNA expression were significantly reduced in ATZ group.	Atrazine	85-88	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	31-38
30466052-4	2019	The paper-based platform was employed to detect paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine by exploiting the capability of these different types of pesticides (i.e. organophosphorus insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhibit butyrylcholinesterase, alkaline phosphatase, and tyrosinase, respectively.	Atrazine	94-102	butyrylcholinesterase	Homo sapiens	268-289
30466052-4	2019	The paper-based platform was employed to detect paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine by exploiting the capability of these different types of pesticides (i.e. organophosphorus insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhibit butyrylcholinesterase, alkaline phosphatase, and tyrosinase, respectively.	Atrazine	94-102	tyrosinase	Homo sapiens	317-327
30584651-7	2018	The resonance frequency shift is inversely and linearly proportional to the logarithm of atrazine concentrations ranging from 1 ng/mL to 100 mug/mL, with the sensitivity of 3.43 Hz/mug mL-1 and the detection limit of 1 ng/mL, which is significantly lower than the standard established by US Environmental Protection Agency (EPA).	Atrazine	89-97	L1 cell adhesion molecule	Mus musculus	185-189
30743826-5	2018	The already banned priority pesticide atrazine was detected in Ave, Antua, and Leca (up to 41 ng L-1) and simazine in Certima and Leca (up to 26 ng L-1).	Atrazine	38-46	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
30555326-7	2018	However, atrazine down-regulated Scarb1 and Cyp17a1 in the fetal Leydig cell per se and Hsd17b3 and Dhh in the Sertoli cell per se.	Atrazine	9-17	scavenger receptor class B, member 1	Rattus norvegicus	33-39
30555326-7	2018	However, atrazine down-regulated Scarb1 and Cyp17a1 in the fetal Leydig cell per se and Hsd17b3 and Dhh in the Sertoli cell per se.	Atrazine	9-17	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	44-51
30360616-0	2018	Lycopene Triggers Nrf2-AMPK Cross Talk to Alleviate Atrazine-Induced Nephrotoxicity in Mice.	Atrazine	52-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
30084861-1	2018	Atrazine (2-chloro-4-ethylamino-6-isopropylamine-1,3,5-triazine; ATR) has been demonstrated to regulate autophagy- and apoptosis-related proteins in doparminergic neuronal damage.	Atrazine	0-8	ATR serine/threonine kinase	Rattus norvegicus	65-68
30439577-4	2019	The introduction of L-GQS was found to exhibit enhanced catalytic ozonation of atrazine, with the increase in degradation rate and the dissolved organic carbon (DOC) removal being more than 2-fold for the catalytic process (L-GQS dosage = 5 g L-1, [atrazine]0 = 50 muM, [O3] = 25 mg L-1, gas flow = 0.2 L min-1, at pH 7.0 and 293 K).	Atrazine	79-87	immunoglobulin kappa variable 1-16	Homo sapiens	243-246
30439577-4	2019	The introduction of L-GQS was found to exhibit enhanced catalytic ozonation of atrazine, with the increase in degradation rate and the dissolved organic carbon (DOC) removal being more than 2-fold for the catalytic process (L-GQS dosage = 5 g L-1, [atrazine]0 = 50 muM, [O3] = 25 mg L-1, gas flow = 0.2 L min-1, at pH 7.0 and 293 K).	Atrazine	79-87	immunoglobulin kappa variable 1-16	Homo sapiens	283-286
30010721-0	2019	Reduction of Kiss1 expression in the anteroventral periventricular nucleus is associated with atrazine-induced attenuation of the luteinizing hormone surge in female rats.	Atrazine	94-102	KiSS-1 metastasis-suppressor	Rattus norvegicus	13-18
30010721-8	2019	However, Kiss1 mRNA expression levels in the AVPV were significantly reduced in the atrazine-treated animals.	Atrazine	84-92	KiSS-1 metastasis-suppressor	Rattus norvegicus	9-14
30010721-9	2019	Given the normal response of GnRH neurons to exogenously administered kisspeptin, the suppressive effect of atrazine may be explained by suppression of Kiss1 expression in the AVPV leading to the attenuation of kisspeptin release from kisspeptin neurons in the AVPV.	Atrazine	108-116	KiSS-1 metastasis-suppressor	Rattus norvegicus	152-157
30010721-10	2019	Further studies are warranted to elucidate more precisely the mechanism of atrazine"s involvement in the suppression of Kiss1 mRNA expression in the AVPV.	Atrazine	75-83	KiSS-1 metastasis-suppressor	Rattus norvegicus	120-125
30007155-13	2018	Atrazine had an immunomodulatory effect on the spleen, observed by the alteration in the percentage of red and white pulp, alteration of the MMC area, changes in the melanomacrophage pigment content, slight iNOS suppression, decrease in splenocyte proliferation under 1 ppm atrazine, and increased caspase 3 activity under 2 ppm atrazine after 7 and 15 d. Such effects could compromise oxygenation and the immune response and, ultimately, the survival and fitness of the fish.	Atrazine	0-8	caspase 3, apoptosis-related cysteine peptidase a	Oreochromis niloticus	298-307
30200244-8	2018	The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides.	Atrazine	24-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-9
29319411-0	2018	Cantilever nanobiosensor using tyrosinase to detect atrazine in liquid medium.	Atrazine	52-60	tyrosinase	Homo sapiens	31-41
29319411-1	2018	The aim of this study was to develop a cantilever nanobiosensor for atrazine detection in liquid medium by immobilising the biological recognition element (tyrosinase vegetal extract) on its surface with self-assembled monolayers using gold, 16-mercaptohexadecanoic acid, 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride/n-hydroxysuccinimide.	Atrazine	68-76	tyrosinase	Homo sapiens	156-166
29319411-5	2018	Thus, the cantilever nanobiosensor developed for this study using low cost tyrosinase vegetal extract was adequate for atrazine detection, a potential tool in the environmental field.	Atrazine	119-127	tyrosinase	Homo sapiens	75-85
29407820-6	2018	The newly synthesized Fe(III)-ATTP-PANI composite exhibited superior reactivity as indicated by the efficient dissipation of atrazine in the presence of hydrogen peroxide (H2O2), and the degradation rate increased up to almost 150 times compared to Fe(III)-ATTP.	Atrazine	125-133	UEV and lactate/malate dehyrogenase domains	Homo sapiens	30-34
29407820-7	2018	The higher reactivity of Fe(III)-ATTP-PANI/H2O2 system was attributed to the accelerated electron transfer, the formation of ferrous ions, and the enhanced adsorption of atrazine onto attapulgite.	Atrazine	170-178	UEV and lactate/malate dehyrogenase domains	Homo sapiens	33-37
29329451-7	2018	Chlordane, trans-nonachlor, PCB-126, PCB-153, and atrazine were the most potent EGFR inhibitors tested.	Atrazine	50-58	epidermal growth factor receptor	Homo sapiens	80-84
29329451-9	2018	However, atrazine acted through a different mechanism and could be an EGFR tyrosine kinase inhibitor.	Atrazine	9-17	epidermal growth factor receptor	Homo sapiens	70-74
28640859-5	2017	Atrazine exposure not only triggered a DNA damage response but also decreased MPF levels in porcine oocytes.	Atrazine	0-8	mesothelin	Homo sapiens	78-81
28741978-3	2017	Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased.	Atrazine	171-174	catalase	Rattus norvegicus	43-51
28847621-4	2017	Exposition of rats to 200mg/kg of atrazine resulted in transient increase in testicular weight, seminiferous tubules dilation and atrophy, and reduction in Leydig cell 3beta-HSD.	Atrazine	34-42	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	168-177
28918279-10	2018	With atrazine herbicide groundwater concentrations being &gt;130ngL-1 for all seasons and groundwater  triazine herbicide concentrations ranging between 527 and 367ngL-1, triazine compounds in the Hartbeespoort Dam catchment may pose a risk to humans and wildlife in light findings of endocrine and immune disrupting atrazine effects by various researchers.	Atrazine	5-13	leucine rich repeat containing 4C	Homo sapiens	64-69
29324720-0	2018	Biointeractions of Herbicide Atrazine with Human Serum Albumin: UV-Vis, Fluorescence and Circular Dichroism Approaches.	Atrazine	29-37	albumin	Homo sapiens	49-62
28859886-0	2017	Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression.	Atrazine	0-8	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2	Danio rerio	86-90
28859886-4	2017	In this study, the effects of atrazine exposure on DNA methyltransferase (DNMT) activity and kinetics were evaluated.	Atrazine	30-38	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2	Danio rerio	51-72
28859886-4	2017	In this study, the effects of atrazine exposure on DNA methyltransferase (DNMT) activity and kinetics were evaluated.	Atrazine	30-38	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2	Danio rerio	74-78
28859886-7	2017	Furthermore, results show that an embryonic atrazine exposure decreases global methylation levels and the expression of dnmt4 and dnmt5.	Atrazine	44-52	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1	Danio rerio	120-125
28859886-7	2017	Furthermore, results show that an embryonic atrazine exposure decreases global methylation levels and the expression of dnmt4 and dnmt5.	Atrazine	44-52	DNA (cytosine-5-)-methyltransferase beta, duplicate b.3	Danio rerio	130-135
28640859-6	2017	Our results also revealed that atrazine worsened porcine oocyte quality by causing excessive accumulation of superoxide radicals, increasing cathepsin B activity, and decreasing the GSH level and mitochondrial membrane potential.	Atrazine	31-39	cathepsin B	Homo sapiens	141-152
28640859-8	2017	Collectively, our results indicate that porcine oocyte maturation is defective after atrazine treatment at least through disruption of spindle morphology, MPF activity, and mitochondrial function and via induction of DNA damage, which probably reduces developmental competence.	Atrazine	85-93	mesothelin	Homo sapiens	155-158
27494660-10	2016	For atrazine, concentrations were found in the range from 2.0 to 6.0ngL-1 in drinking water and at concentrations of up to 15ngL-1 in source water.	Atrazine	4-12	leucine rich repeat containing 4C	Homo sapiens	68-73
28240863-4	2017	Adsorptive performances for the removal of organic contaminants, atrazine (ATZ), diuron, and diclofenac, were remarkably enhanced with the modification/conversion of MOFs to MDC and IMDC.	Atrazine	65-73	C-C motif chemokine ligand 22	Homo sapiens	174-177
28240863-4	2017	Adsorptive performances for the removal of organic contaminants, atrazine (ATZ), diuron, and diclofenac, were remarkably enhanced with the modification/conversion of MOFs to MDC and IMDC.	Atrazine	75-78	C-C motif chemokine ligand 22	Homo sapiens	174-177
28240863-5	2017	For example, in the case of ATZ adsorption, the maximum adsorption capacity of IMDC (Q0 = 208 m2/g) was much higher than that of activated carbon (AC, Q0 = 60 m2/g) and MDC (Q0 = 168 m2/g) and was found to be the highest among the reported results so far.	Atrazine	28-31	C-C motif chemokine ligand 22	Homo sapiens	80-83
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	thioredoxin reductase 2	Drosophila melanogaster	139-145
28469190-4	2017	The degradation of atrazine follows a second-order kinetic model with constant values of K2 = 1.7957 g mg-1 min-1 for MK10_PEI_Cu NPs and K2 = 0.8133 g mg-1 min-1 for sand_PEI_Cu NPs.	Atrazine	19-27	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
28469190-4	2017	The degradation of atrazine follows a second-order kinetic model with constant values of K2 = 1.7957 g mg-1 min-1 for MK10_PEI_Cu NPs and K2 = 0.8133 g mg-1 min-1 for sand_PEI_Cu NPs.	Atrazine	19-27	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	103-113
27335015-3	2017	Atrazine was the most frequently detected herbicide in drinking (84 % of samples) and ground (61 % of samples) waters in mass concentrations of 5 to 68 ng L-1.	Atrazine	0-8	immunoglobulin kappa variable 1-16	Homo sapiens	155-158
27697710-3	2017	It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfalpha, Il-1beta, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish.	Atrazine	21-24	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	120-128
27697710-3	2017	It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfalpha, Il-1beta, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish.	Atrazine	21-24	interleukin 1, beta	Danio rerio	130-138
27697710-3	2017	It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfalpha, Il-1beta, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish.	Atrazine	21-24	interleukin 6 (interferon, beta 2)	Danio rerio	140-144
27697710-3	2017	It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfalpha, Il-1beta, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish.	Atrazine	21-24	chemokine (C-X-C motif) ligand 8a	Danio rerio	146-150
27697710-3	2017	It was observed that ATZ, DACT, DIP and DE selectively induced the transcription of immunotoxic related genes including Tnfalpha, Il-1beta, Il-6, Il-8, Cxcl-clc and Cc-chem in larval zebrafish.	Atrazine	21-24	chemokine (C-X-C motif) ligand 18b	Danio rerio	152-160
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Keap1	Drosophila melanogaster	77-82
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Superoxide dismutase 1	Drosophila melanogaster	84-87
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	89-93
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Immune-regulated catalase	Drosophila melanogaster	100-103
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Glutathione synthetase 1	Drosophila melanogaster	105-108
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Glutamate-cysteine ligase modifier subunit	Drosophila melanogaster	110-114
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Glutamate-cysteine ligase catalytic subunit	Drosophila melanogaster	116-120
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Thioredoxin T	Drosophila melanogaster	122-126
27687474-9	2017	Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2).	Atrazine	9-17	Thioredoxin reductase-1	Drosophila melanogaster	128-134
27437951-7	2016	Furthermore, Synechococcus PCC 7002 expressing CYP1A1 degraded the herbicide atrazine, which is a widespread environmental pollutant.	Atrazine	77-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53
27494660-10	2016	For atrazine, concentrations were found in the range from 2.0 to 6.0ngL-1 in drinking water and at concentrations of up to 15ngL-1 in source water.	Atrazine	4-12	leucine rich repeat containing 4C	Homo sapiens	125-130
27391035-4	2016	Atrazine toxicity increased ROS production and enzyme activities (ascorbate peroxidase APX, peroxidase POD, Superoxide dismutase SOD, glutathione-S-transferase GST); but decreased antioxidants (APX, POD, and Cu/Zn SOD) and psbA gene transcripts.	Atrazine	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	87-90
27391035-4	2016	Atrazine toxicity increased ROS production and enzyme activities (ascorbate peroxidase APX, peroxidase POD, Superoxide dismutase SOD, glutathione-S-transferase GST); but decreased antioxidants (APX, POD, and Cu/Zn SOD) and psbA gene transcripts.	Atrazine	0-8	superoxide dismutase 1	Homo sapiens	129-132
27391035-4	2016	Atrazine toxicity increased ROS production and enzyme activities (ascorbate peroxidase APX, peroxidase POD, Superoxide dismutase SOD, glutathione-S-transferase GST); but decreased antioxidants (APX, POD, and Cu/Zn SOD) and psbA gene transcripts.	Atrazine	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	194-197
27391035-4	2016	Atrazine toxicity increased ROS production and enzyme activities (ascorbate peroxidase APX, peroxidase POD, Superoxide dismutase SOD, glutathione-S-transferase GST); but decreased antioxidants (APX, POD, and Cu/Zn SOD) and psbA gene transcripts.	Atrazine	0-8	superoxide dismutase 1	Homo sapiens	214-217
25640594-0	2016	Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway.	Atrazine	0-8	caspase 8	Homo sapiens	90-99
27391035-7	2016	Ca-protected seedlings in the presence of atrazine manifested reduced APX and POD activity, whereas SOD and GST activity was further increased with Ca application.	Atrazine	42-50	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	70-73
27371663-7	2016	RESULTS: Atrazine was detected in water samples from 69 cities where 4155 women (32%) lived and levels were moderately correlated with NO3-N (rho=0.35) and TTHM (rho=0.24).	Atrazine	9-17	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
27554787-0	2016	Atrazine activates multiple signaling pathways enhancing the rapid hCG-induced androgenesis in rat Leydig cells.	Atrazine	0-8	hypertrichosis 2 (generalised, congenital)	Homo sapiens	67-70
27554787-9	2016	Co-treatment with ATR for 120min further enhanced the hCG-induced androgen production, which was prevented by inhibition of the calcium, PKC and EGFR signaling cascades.	Atrazine	18-21	hypertrichosis 2 (generalised, congenital)	Homo sapiens	54-57
27554787-9	2016	Co-treatment with ATR for 120min further enhanced the hCG-induced androgen production, which was prevented by inhibition of the calcium, PKC and EGFR signaling cascades.	Atrazine	18-21	epidermal growth factor receptor	Rattus norvegicus	145-149
27102619-0	2016	Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway.	Atrazine	21-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
25427686-4	2016	The rats given ATZ alone also had significantly decreased 3beta-hydroxtsteroid dehydrogenase (HSD) and 17beta-HSD activities than the control rats.	Atrazine	15-18	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	103-113
27102619-0	2016	Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway.	Atrazine	21-29	heme oxygenase 1	Rattus norvegicus	112-116
26841231-6	2016	The superiority of the novel ZnO/CdS/TiO2 hybrid over the traditional CdS/TiO2 hybrid in both photocatalytic activity and anti-photocorrosion capacity was demonstrated in the degradation of Atrazine and Rhodamine B, two typical refractory organic pollutants, and the treatment of real textile wastewater under solar light irradiation.	Atrazine	190-198	CDP-diacylglycerol synthase 1	Homo sapiens	33-36
26984284-0	2016	Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.	Atrazine	0-8	signal transducer and activator of transcription 3	Mus musculus	71-76
26984284-8	2016	Interestingly, RM1 cell proliferation was increased after treatment with atrazine, concomitantly with STAT3 signaling activation.	Atrazine	73-81	signal transducer and activator of transcription 3	Mus musculus	102-107
26984284-9	2016	These results suggest that atrazine promotes RM1 cell growth in vitro and in vivo by activating STAT3 signaling.	Atrazine	27-35	signal transducer and activator of transcription 3	Mus musculus	96-101
26762862-0	2016	Atrazine reduces the transmission of an amphibian trematode by altering snail and ostracod host-parasite interactions.	Atrazine	0-8	snail family transcriptional repressor 1	Homo sapiens	72-77
26762862-3	2016	Here, we test the effects of environmentally relevant concentrations of the herbicide atrazine (0, 3, 30 mug/L) on the establishment and development of an amphibian trematode (Halipegus eccentricus) in a first-intermediate snail host (Physa acuta) and in a second-intermediate ostracod host (Cypridopsis sp.).	Atrazine	86-94	snail family transcriptional repressor 1	Homo sapiens	223-228
26762862-5	2016	Our results indicate that atrazine negatively affects trematode transmission by altering snail and ostracod host-parasite interactions.	Atrazine	26-34	snail family transcriptional repressor 1	Homo sapiens	89-94
26686575-7	2016	We found that both atrazine and malathion shortened the frog oocyte maturation process and resulted in reduced Emi2 levels at cytostatic factor-mediated metaphase arrest, and a high level of Emi2 is critically important for oocyte maturation.	Atrazine	19-27	F-box protein 43 L homeolog	Xenopus laevis	111-115
26686575-7	2016	We found that both atrazine and malathion shortened the frog oocyte maturation process and resulted in reduced Emi2 levels at cytostatic factor-mediated metaphase arrest, and a high level of Emi2 is critically important for oocyte maturation.	Atrazine	19-27	F-box protein 43 L homeolog	Xenopus laevis	191-195
26923738-0	2016	Atrazine blocks ovulation via suppression of Lhr and Cyp19a1 mRNA and estradiol secretion in immature gonadotropin-treated rats.	Atrazine	0-8	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	45-48
26923738-0	2016	Atrazine blocks ovulation via suppression of Lhr and Cyp19a1 mRNA and estradiol secretion in immature gonadotropin-treated rats.	Atrazine	0-8	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	53-60
26841231-6	2016	The superiority of the novel ZnO/CdS/TiO2 hybrid over the traditional CdS/TiO2 hybrid in both photocatalytic activity and anti-photocorrosion capacity was demonstrated in the degradation of Atrazine and Rhodamine B, two typical refractory organic pollutants, and the treatment of real textile wastewater under solar light irradiation.	Atrazine	190-198	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
26724435-8	2016	The different trend of them formed in UV/chlorine system (DEA:DIA 4) compared to that formed in UV/H2O2 system (DEA:DIA 1) could be ascribed to the different reaction reactivities and mechanisms between HO  and Cl  with atrazine.	Atrazine	220-228	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-67
27114639-10	2016	CONCLUSION: Results suggest that TFAM and SIRT1 could be involved in atrazine-induced mitochondrial dysfunction, and further studies can be taken up to understand the mechanism of mitochondrial toxicity.	Atrazine	69-77	transcription factor A, mitochondrial	Homo sapiens	33-37
27114639-10	2016	CONCLUSION: Results suggest that TFAM and SIRT1 could be involved in atrazine-induced mitochondrial dysfunction, and further studies can be taken up to understand the mechanism of mitochondrial toxicity.	Atrazine	69-77	sirtuin 1	Homo sapiens	42-47
26724435-8	2016	The different trend of them formed in UV/chlorine system (DEA:DIA 4) compared to that formed in UV/H2O2 system (DEA:DIA 1) could be ascribed to the different reaction reactivities and mechanisms between HO  and Cl  with atrazine.	Atrazine	220-228	diaphanous related formin 1	Homo sapiens	116-121
25158112-8	2016	Acute (48 and 72 h) exposure of 24 h-old embryos to atrazine, from environmentally relevant (0.005 mg/L) to high (40 mg/L) concentrations, caused a variety of transient, albeit minor changes (&lt;2.5-fold) in the GST isoforms, ahr2 and AOE genes response.	Atrazine	52-60	aryl hydrocarbon receptor 2	Danio rerio	227-231
25158112-9	2016	However, expression of cyp1a and cyp3a65 mRNA was markedly and consistently induced by high doses of atrazine (5 and 40 mg/L).	Atrazine	101-109	cytochrome P450, family 1, subfamily A	Danio rerio	23-28
25158112-9	2016	However, expression of cyp1a and cyp3a65 mRNA was markedly and consistently induced by high doses of atrazine (5 and 40 mg/L).	Atrazine	101-109	cytochrome P450, family 3, subfamily A, polypeptide 65	Danio rerio	33-40
26581813-4	2015	Despite a longstanding EU-wide ban we were able to detect atrazine in the Mediterranean and the Baltic Sea.	Atrazine	58-66	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	103-106
26955487-2	2016	GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized chlorotriazines in agricultural practices in the United States.	Atrazine	134-142	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
25989523-6	2015	However, when Pb(II)/Cr(VI) metal ions coexist in solution, they substantially suppress atrazine adsorption, probably because the inner complex between the hydroxyl groups on SDBCs and Pb(II)/Cr(III) ions intrude the weak H-bond with atrazine.	Atrazine	88-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	14-20
26464060-7	2016	In H295R cells, atrazine concentration-dependently increased PII- and I.3-mediated CYP19 expression and aromatase catalytic activity.	Atrazine	16-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	83-88
26464060-7	2016	In H295R cells, atrazine concentration-dependently increased PII- and I.3-mediated CYP19 expression and aromatase catalytic activity.	Atrazine	16-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	104-113
26464060-9	2016	In HUVEC cells, atrazine slightly induced overall (promoter-indistinct) CYP19 expression (30 microM) and aromatase activity (&gt;= 3 microM), without increasing I.1 promoter activity.	Atrazine	16-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	72-77
26464060-9	2016	In HUVEC cells, atrazine slightly induced overall (promoter-indistinct) CYP19 expression (30 microM) and aromatase activity (&gt;= 3 microM), without increasing I.1 promoter activity.	Atrazine	16-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	105-114
26390431-2	2015	strain ADP, AtzC, provides the third hydrolytic step in the mineralization of s-triazine herbicides, such as atrazine.	Atrazine	109-117	AtzC	Pseudomonas sp. ADP	12-16
26464060-5	2016	Exposure to certain pesticides, such as atrazine, is associated with increased CYP19 expression, but little is known about the effects of neonicotinoid insecticides on CYP19.	Atrazine	40-48	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	79-84
26464060-6	2016	We developed sensitive and robust RT-qPCR methods to detect the promoter-specific expression of CYP19 in human adrenocortical carcinoma (H295R) and primary umbilical vein endothelial (HUVEC) cells, and determined the potential promoter-specific disruption of CYP19 expression by atrazine and the commonly used neonicotinoids imidacloprid, thiacloprid, and thiamethoxam.	Atrazine	279-287	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	96-101
26256823-1	2015	Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR) is a broad-spectrum herbicide with a wide range of applications worldwide.	Atrazine	0-8	ATR serine/threonine kinase	Homo sapiens	66-69
25989523-6	2015	However, when Pb(II)/Cr(VI) metal ions coexist in solution, they substantially suppress atrazine adsorption, probably because the inner complex between the hydroxyl groups on SDBCs and Pb(II)/Cr(III) ions intrude the weak H-bond with atrazine.	Atrazine	88-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	185-191
25989523-6	2015	However, when Pb(II)/Cr(VI) metal ions coexist in solution, they substantially suppress atrazine adsorption, probably because the inner complex between the hydroxyl groups on SDBCs and Pb(II)/Cr(III) ions intrude the weak H-bond with atrazine.	Atrazine	234-242	submaxillary gland androgen regulated protein 3B	Homo sapiens	14-20
25989523-6	2015	However, when Pb(II)/Cr(VI) metal ions coexist in solution, they substantially suppress atrazine adsorption, probably because the inner complex between the hydroxyl groups on SDBCs and Pb(II)/Cr(III) ions intrude the weak H-bond with atrazine.	Atrazine	234-242	submaxillary gland androgen regulated protein 3B	Homo sapiens	185-191
25752436-0	2015	Atrazine induces apoptosis of SH-SY5Y human neuroblastoma cells via the regulation of Bax/Bcl-2 ratio and caspase-3-dependent pathway.	Atrazine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	86-89
25991912-5	2015	The kinetics and thermodynamics studies also further elucidated the detailed adsorption characteristics of atrazine removal by PA6/PPy NFM.	Atrazine	107-115	neurofilament medium chain	Homo sapiens	135-138
25991912-10	2015	These results suggest that PA6/PPy NFM could be employed as an efficient adsorbent for removing atrazine from contaminated water sources.	Atrazine	96-104	neurofilament medium chain	Homo sapiens	35-38
25616260-0	2015	Effects of atrazine on estrogen receptor alpha- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.	Atrazine	11-19	estrogen receptor 1	Homo sapiens	23-40
25616260-1	2015	BACKGROUND: The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells.	Atrazine	26-34	estrogen receptor 1	Homo sapiens	78-95
25616260-1	2015	BACKGROUND: The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells.	Atrazine	26-34	estrogen receptor 1	Homo sapiens	97-99
25616260-3	2015	OBJECTIVES: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts (CAFs).	Atrazine	50-58	G protein-coupled estrogen receptor 1	Homo sapiens	70-74
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	mitogen-activated protein kinase 1	Homo sapiens	56-59
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	163-167
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	estrogen receptor 1	Homo sapiens	172-179
25616260-6	2015	As a biological counterpart, atrazine stimulated the proliferation of ovarian cancer cells that depend on GPER and ERalpha, as evidenced by gene silencing experiments and the use of specific signaling inhibitors.	Atrazine	29-37	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
25616260-6	2015	As a biological counterpart, atrazine stimulated the proliferation of ovarian cancer cells that depend on GPER and ERalpha, as evidenced by gene silencing experiments and the use of specific signaling inhibitors.	Atrazine	29-37	estrogen receptor 1	Homo sapiens	115-122
25616260-7	2015	Of note, through GPER, atrazine elicited ERK phosphorylation, gene expression, and migration in CAFs, thus extending its stimulatory role to these main players of the tumor microenvironment.	Atrazine	23-31	G protein-coupled estrogen receptor 1	Homo sapiens	17-21
25616260-7	2015	Of note, through GPER, atrazine elicited ERK phosphorylation, gene expression, and migration in CAFs, thus extending its stimulatory role to these main players of the tumor microenvironment.	Atrazine	23-31	mitogen-activated protein kinase 1	Homo sapiens	41-44
25616260-9	2015	On the basis of our data, atrazine should be included among the environmental contaminants that may elicit estrogenic activity through GPER-mediated signaling.	Atrazine	26-34	G protein-coupled estrogen receptor 1	Homo sapiens	135-139
25343875-5	2015	As pollen donor an Arabidopsis accession (Ler-Ely) was used, which carried a plastid-localized atrazine resistance due to a point mutation in the psbA gene.	Atrazine	95-103	photosystem II protein D1	Arabidopsis thaliana	146-150
26114388-4	2015	Our results indicate that a short-term exposure of MCF-10A to an environmentally-detectable concentration of atrazine (0.1 microg/mL) significantly increased the expression of tumor necrosis factor receptor-1 (TNFR1) and phosphorylated Rad17 in the cells.	Atrazine	109-117	TNF receptor superfamily member 1A	Homo sapiens	176-208
26114388-4	2015	Our results indicate that a short-term exposure of MCF-10A to an environmentally-detectable concentration of atrazine (0.1 microg/mL) significantly increased the expression of tumor necrosis factor receptor-1 (TNFR1) and phosphorylated Rad17 in the cells.	Atrazine	109-117	TNF receptor superfamily member 1A	Homo sapiens	210-215
26114388-4	2015	Our results indicate that a short-term exposure of MCF-10A to an environmentally-detectable concentration of atrazine (0.1 microg/mL) significantly increased the expression of tumor necrosis factor receptor-1 (TNFR1) and phosphorylated Rad17 in the cells.	Atrazine	109-117	RAD17 checkpoint clamp loader component	Homo sapiens	236-241
26114388-5	2015	Atrazine treatment increased H2AX phosphorylation (gammaH2AX) and the formation of gammaH2AX foci in the nuclei of MCF-10A cells.	Atrazine	0-8	H2A.X variant histone	Homo sapiens	29-33
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	0-8	ATR serine/threonine kinase	Homo sapiens	93-96
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	0-8	ATR interacting protein	Homo sapiens	99-104
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	0-8	checkpoint kinase 1	Homo sapiens	117-121
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	0-8	ATR serine/threonine kinase	Homo sapiens	99-102
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	0-8	checkpoint kinase 1	Homo sapiens	226-230
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	139-147	ATR serine/threonine kinase	Homo sapiens	93-96
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	139-147	ATR interacting protein	Homo sapiens	99-104
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	139-147	checkpoint kinase 1	Homo sapiens	117-121
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	139-147	ATR serine/threonine kinase	Homo sapiens	99-102
26114388-6	2015	Atrazine also sequentially elevated DNA damage checkpoint proteins of ATM- and RAD3-related (ATR), ATRIP and phospho-Chk1, suggesting that atrazine could induce DNA double-strand breaks and trigger the DNA damage response ATR-Chk1 pathway in MCF-10A cells.	Atrazine	139-147	checkpoint kinase 1	Homo sapiens	226-230
26075868-1	2015	Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR) is widely used as a broad-spectrum herbicide.	Atrazine	0-8	ATR serine/threonine kinase	Rattus norvegicus	66-69
25860072-2	2015	Herein, the use for the detection of SM2 of a portable optofluidics-based biosensing platform, which was used for the accurate detection of bisphenol A, atrazine and melamine, is reported for the first time.	Atrazine	153-161	SM2	Homo sapiens	37-40
25544494-2	2015	In this study, we investigated the underlying mechanisms and transformation pathways of atrazine degradation by cobalt catalyzed peroxymonosulfate (Co(II)/PMS).	Atrazine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25544494-2	2015	In this study, we investigated the underlying mechanisms and transformation pathways of atrazine degradation by cobalt catalyzed peroxymonosulfate (Co(II)/PMS).	Atrazine	88-96	proline rich protein BstNI subfamily 1	Homo sapiens	155-158
25273519-9	2015	The product of Freundlich adsorption constants, K f(1/n) in HDTMA-, TOMA-, and SK-I-bentonites was 239.2, 302.4, and 256.6, respectively, while increasing the SK cation loading in the clay (SK-II) decreased atrazine adsorption [K f(1/n) - 196.4].	Atrazine	207-215	SKI proto-oncogene	Homo sapiens	79-83
25273519-10	2015	Desorption of atrazine from organoclays showed hysteresis and TOMA- and SK-I-bentonites were the best organoclays to retain the adsorbed atrazine.	Atrazine	137-145	SKI proto-oncogene	Homo sapiens	72-76
25752436-0	2015	Atrazine induces apoptosis of SH-SY5Y human neuroblastoma cells via the regulation of Bax/Bcl-2 ratio and caspase-3-dependent pathway.	Atrazine	0-8	BCL2 apoptosis regulator	Homo sapiens	90-95
25752436-0	2015	Atrazine induces apoptosis of SH-SY5Y human neuroblastoma cells via the regulation of Bax/Bcl-2 ratio and caspase-3-dependent pathway.	Atrazine	0-8	caspase 3	Homo sapiens	106-115
25433234-0	2015	In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.	Atrazine	35-43	forkhead box P3	Mus musculus	156-161
25433234-4	2015	In this study we have examined the impact of in vitro atrazine exposure on the activation, proliferation, and effector cytokine production by primary murine CD4(+) T lymphocytes.	Atrazine	54-62	CD4 antigen	Mus musculus	157-160
25433234-5	2015	We found that atrazine exposure significantly inhibited CD4(+) T cell proliferation and accumulation as well as the expression of the activation markers CD25 and CD69 in a dose-dependent manner.	Atrazine	14-22	CD4 antigen	Mus musculus	56-59
25433234-5	2015	We found that atrazine exposure significantly inhibited CD4(+) T cell proliferation and accumulation as well as the expression of the activation markers CD25 and CD69 in a dose-dependent manner.	Atrazine	14-22	interleukin 2 receptor, alpha chain	Mus musculus	153-157
25433234-5	2015	We found that atrazine exposure significantly inhibited CD4(+) T cell proliferation and accumulation as well as the expression of the activation markers CD25 and CD69 in a dose-dependent manner.	Atrazine	14-22	CD69 antigen	Mus musculus	162-166
25433234-8	2015	Consistent with these findings, atrazine exposure during T cell activation resulted in a 2- to 5-fold increase in the frequency of Foxp3(+) CD4(+) T cells.	Atrazine	32-40	forkhead box P3	Mus musculus	131-136
25433234-8	2015	Consistent with these findings, atrazine exposure during T cell activation resulted in a 2- to 5-fold increase in the frequency of Foxp3(+) CD4(+) T cells.	Atrazine	32-40	CD4 antigen	Mus musculus	140-143
25138046-1	2014	This study determines the effect of atrazine and fenitrothion no-observed-effect-levels (NOEL) on the binding of corticosterone (B) to corticosterone-binding-globulin (CBG) in an amphibian and a mammal.	Atrazine	36-44	serpin family A member 6	Homo sapiens	135-166
25362066-2	2015	strain ADP, AtzF, provides the final hydrolytic step for the mineralization of s-triazines, such as atrazine and cyanuric acid.	Atrazine	100-108	atzF	Pseudomonas sp. ADP	12-16
25996812-8	2015	In the case of atrazine, K(i) were found to be 8.99 x 10(-3), 3.55 x 10(-2) and 1.36 x 10(-2) mM for plant ACP, earthworms ALP and cotton leafworm ALP, respectively.	Atrazine	15-23	acid phosphatase 1	Solanum lycopersicum	107-110
25138046-4	2014	Competition studies showed that both atrazine and fenitrothion at NOEL are able to compete with B for CBG binding sites in toad and rat plasma.	Atrazine	37-45	serpin family A member 6	Rattus norvegicus	102-105
25138046-9	2014	This is the first time that the potential disruptive effect of atrazine and fenitrothion on B-CBG interaction at the NOELs has been demonstrated in amphibian and mammalian models.	Atrazine	63-71	serpin family A member 6	Homo sapiens	94-97
24984115-8	2014	In contrast, acute atrazine exposure of mature adult frogs did not induce detectable effects on anti-FV3 immunity, but adults that were exposed to atrazine during metamorphosis exhibited pronounced defects in FV3-induced TNF-alpha gene expression responses and slight diminution in type I IFN gene induction.	Atrazine	147-155	tumor necrosis factor L homeolog	Xenopus laevis	221-230
25419354-2	2014	In this experiment, 4 weeks old female Wister rats were treated by 0, 5, 25 and 125 mg/kg atrazine respectively for 28 days, and the oxidative stress responses as well as the activations of Nrf2 signaling pathway in kidney tissues induced by atrazine were observed.	Atrazine	242-250	NFE2 like bZIP transcription factor 2	Rattus norvegicus	190-194
25253736-9	2014	Atrazine intensified AKT and CEBPB signaling and caused Star overexpression in forskolin-stimulated GC but not in epidermal growth factor (EGF)-stimulated GC.	Atrazine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	21-24
25253736-9	2014	Atrazine intensified AKT and CEBPB signaling and caused Star overexpression in forskolin-stimulated GC but not in epidermal growth factor (EGF)-stimulated GC.	Atrazine	0-8	CCAAT/enhancer binding protein beta	Rattus norvegicus	29-34
24863870-8	2014	From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.	Atrazine	86-94	caspase 3	Homo sapiens	193-202
25275554-9	2014	Our results indicate that transgenic atzA rice plants show tolerance to atrazine, and may be used as parental lines in future hybrid seed production.	Atrazine	72-80	atzA	Pseudomonas sp. ADP	37-41
25275270-7	2014	The most up-regulated phosphoprotein by atrazine treatment, ANP32A, was further analyzed for its expression, distribution and cellular localization using Western blot and immunocytochemical approaches.	Atrazine	40-48	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	60-66
24211529-0	2014	Atrazine represses S100A4 gene expression and TPA-induced motility in HepG2 cells.	Atrazine	0-8	S100 calcium binding protein A4	Homo sapiens	19-25
25031697-0	2014	Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.	Atrazine	46-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	10-14
25031697-2	2014	In this experiment, Wistar rats were treated by 5, 25 and 125 mg kg(-1) atrazine respectively for 28 days, and the oxidative stress responses as well as the activations of Nrf2 signaling pathway in ovarian tissues induced by atrazine were observed.	Atrazine	225-233	NFE2 like bZIP transcription factor 2	Rattus norvegicus	172-176
25031697-3	2014	The results showed that after be treated by atrazine, the proportion of atretic follicles in the rat ovary were increased, the contents of NO and MDA in the tissue homogenates were increased, the over-expressed Nrf2 transferred into the nuclei and played an antioxidant role by up-regulated the expression of II phase detoxifying enzymes such as HO1 and NQO1 and the expression of antioxidant enzymes such as CAT, SOD and GSH-PX.	Atrazine	44-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	211-215
25031697-3	2014	The results showed that after be treated by atrazine, the proportion of atretic follicles in the rat ovary were increased, the contents of NO and MDA in the tissue homogenates were increased, the over-expressed Nrf2 transferred into the nuclei and played an antioxidant role by up-regulated the expression of II phase detoxifying enzymes such as HO1 and NQO1 and the expression of antioxidant enzymes such as CAT, SOD and GSH-PX.	Atrazine	44-52	heme oxygenase 1	Rattus norvegicus	346-349
25031697-3	2014	The results showed that after be treated by atrazine, the proportion of atretic follicles in the rat ovary were increased, the contents of NO and MDA in the tissue homogenates were increased, the over-expressed Nrf2 transferred into the nuclei and played an antioxidant role by up-regulated the expression of II phase detoxifying enzymes such as HO1 and NQO1 and the expression of antioxidant enzymes such as CAT, SOD and GSH-PX.	Atrazine	44-52	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	354-358
25031697-3	2014	The results showed that after be treated by atrazine, the proportion of atretic follicles in the rat ovary were increased, the contents of NO and MDA in the tissue homogenates were increased, the over-expressed Nrf2 transferred into the nuclei and played an antioxidant role by up-regulated the expression of II phase detoxifying enzymes such as HO1 and NQO1 and the expression of antioxidant enzymes such as CAT, SOD and GSH-PX.	Atrazine	44-52	glutathione peroxidase 1	Rattus norvegicus	422-428
24561379-7	2014	Exposure of juvenile rats to the high dose of atrazine led to reduced levels of DA and mRNA of Nurr1 in one-year-old animals.	Atrazine	46-54	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	95-100
24893294-0	2014	Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish.	Atrazine	11-19	acetylcholinesterase	Danio rerio	84-104
24893294-12	2014	Although ATZ did not affect muscular AChE, it significantly reduced AChE activity in brain.	Atrazine	9-12	acetylcholinesterase	Danio rerio	68-72
24486430-6	2014	Atrazine and prochloraz had cell-type specific effects on CYP19 activity and estrogen production in co-culture.	Atrazine	0-8	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	58-63
24486430-7	2014	Atrazine induced CYP19 activity and estrogen production in H295R cells only, but did not affect overall estrogen production in co-culture, whereas prochloraz inhibited CYP19 activity exclusively in BeWo cells and reduced estrogen production in co-culture by almost 90%.	Atrazine	0-8	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	17-22
24211529-3	2014	Our investigations on the role of pesticides in liver dysfunctions have led us to detect an inhibition of FSP1 expression of 70% at 50mum and around 95% at 500muM of ATZ (p&lt;0.01).	Atrazine	166-169	S100 calcium binding protein A4	Homo sapiens	106-110
24211529-6	2014	ATZ decreases Fak pathway activation but has no effect on the Erk1/2 pathway known to be involved in metastasis in this cell line.	Atrazine	0-3	protein tyrosine kinase 2	Homo sapiens	14-17
24211529-7	2014	These results suggest that ATZ could be involved in cell homeostasis perturbation, potentially through a S100a4-dependant mechanism.	Atrazine	27-30	S100 calcium binding protein A4	Homo sapiens	105-111
24246238-10	2014	Urinary metabolites of both atrazine and dealkylated triazine were correlated with tap water consumption (OR=2.94, 1.09-7.90, and OR=1.82, 1.10-3.03, respectively); hydroxylated triazine metabolites were correlated with fish intake (OR=1.48, 1.09-1.99).	Atrazine	28-36	nuclear RNA export factor 1	Homo sapiens	83-86
24632104-6	2014	Moreover, the administration of ATZ and DACT decreased the transcription levels of key genes related to cholesterol transport and testosterone (T) synthesis including scavenger receptor class B type 1 (SR-B1), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17alpha-hydroxysteroid dehydrogenase (P450 17alpha) in testes.	Atrazine	32-35	scavenger receptor class B, member 1	Mus musculus	167-200
24632104-6	2014	Moreover, the administration of ATZ and DACT decreased the transcription levels of key genes related to cholesterol transport and testosterone (T) synthesis including scavenger receptor class B type 1 (SR-B1), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17alpha-hydroxysteroid dehydrogenase (P450 17alpha) in testes.	Atrazine	32-35	scavenger receptor class B, member 1	Mus musculus	202-207
24632104-6	2014	Moreover, the administration of ATZ and DACT decreased the transcription levels of key genes related to cholesterol transport and testosterone (T) synthesis including scavenger receptor class B type 1 (SR-B1), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17alpha-hydroxysteroid dehydrogenase (P450 17alpha) in testes.	Atrazine	32-35	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	266-273
24552878-0	2014	Exposure to atrazine during gestation and lactation periods: toxicity effects on dopaminergic neurons in offspring by downregulation of Nurr1 and VMAT2.	Atrazine	12-20	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	136-141
24552878-0	2014	Exposure to atrazine during gestation and lactation periods: toxicity effects on dopaminergic neurons in offspring by downregulation of Nurr1 and VMAT2.	Atrazine	12-20	solute carrier family 18 member A2	Rattus norvegicus	146-151
24552878-1	2014	High atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR) contents in the environment threaten the health conditions of organisms.	Atrazine	5-13	ATR serine/threonine kinase	Rattus norvegicus	71-74
24486480-0	2014	Retraction: G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	123-131	G protein-coupled estrogen receptor 1	Homo sapiens	12-41
24486480-0	2014	Retraction: G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	123-131	estrogen receptor 1	Homo sapiens	46-69
24246781-6	2014	High values of CLR increased removal of estradiol and carbamazepine but lowered that of testosterone and atrazine.	Atrazine	105-113	doublecortin like kinase 3	Homo sapiens	15-18
25349608-3	2014	Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats.	Atrazine	0-8	catalase	Rattus norvegicus	104-107
24218149-11	2014	Dex, PFOS, and atrazine offspring had elevated renal GR gene expression.	Atrazine	15-23	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	53-55
25349608-3	2014	Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats.	Atrazine	145-153	catalase	Rattus norvegicus	104-107
25349608-3	2014	Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats.	Atrazine	166-174	catalase	Rattus norvegicus	104-107
25349608-5	2014	Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats.	Atrazine	0-8	PDZ and LIM domain 3	Rattus norvegicus	101-104
24285376-0	2013	Synthesis of C-13-labeled atrazine.	Atrazine	26-34	homeobox C13	Homo sapiens	13-17
22897171-6	2013	A potentiating response on glutathione-S-transferase and aspartate aminotransferase activities in the testis and on lactate dehydrogenase activity and glutathione level in the epididymis was observed in the QT + ATZ animals.	Atrazine	212-215	hematopoietic prostaglandin D synthase	Rattus norvegicus	27-52
22897171-6	2013	A potentiating response on glutathione-S-transferase and aspartate aminotransferase activities in the testis and on lactate dehydrogenase activity and glutathione level in the epididymis was observed in the QT + ATZ animals.	Atrazine	212-215	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	57-83
23443944-0	2013	Acetylcholinesterase in honey bees (Apis mellifera) exposed to neonicotinoids, atrazine and glyphosate: laboratory and field experiments.	Atrazine	79-87	acetylcholinesterase	Apis mellifera	0-20
23583632-0	2013	Involvement of ERK1/2 signaling pathway in atrazine action on FSH-stimulated LHR and CYP19A1 expression in rat granulosa cells.	Atrazine	43-51	mitogen activated protein kinase 3	Rattus norvegicus	15-21
23583632-0	2013	Involvement of ERK1/2 signaling pathway in atrazine action on FSH-stimulated LHR and CYP19A1 expression in rat granulosa cells.	Atrazine	43-51	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	77-80
23583632-0	2013	Involvement of ERK1/2 signaling pathway in atrazine action on FSH-stimulated LHR and CYP19A1 expression in rat granulosa cells.	Atrazine	43-51	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	85-92
23583632-4	2013	We report that 48h after atrazine exposure the FSH-stimulated LHR and CYP19A1 mRNA expression and estradiol synthesis were decreased, with LHR mRNA being more sensitive to atrazine than CYP19A1 mRNA.	Atrazine	25-33	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	62-65
23583632-4	2013	We report that 48h after atrazine exposure the FSH-stimulated LHR and CYP19A1 mRNA expression and estradiol synthesis were decreased, with LHR mRNA being more sensitive to atrazine than CYP19A1 mRNA.	Atrazine	25-33	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	70-77
23583632-4	2013	We report that 48h after atrazine exposure the FSH-stimulated LHR and CYP19A1 mRNA expression and estradiol synthesis were decreased, with LHR mRNA being more sensitive to atrazine than CYP19A1 mRNA.	Atrazine	25-33	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	139-142
23583632-4	2013	We report that 48h after atrazine exposure the FSH-stimulated LHR and CYP19A1 mRNA expression and estradiol synthesis were decreased, with LHR mRNA being more sensitive to atrazine than CYP19A1 mRNA.	Atrazine	25-33	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	186-193
23583632-6	2013	To dissect the signaling cascade involved in atrazine action in granulosa cells, we used U0126, a pharmacological inhibitor of ERK1/2.	Atrazine	45-53	mitogen activated protein kinase 3	Rattus norvegicus	127-133
23583632-7	2013	U0126 prevents atrazine-induced decrease in LHR and CYP19A1 mRNA levels and estradiol production in the FSH-stimulated granulosa cells.	Atrazine	15-23	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	44-47
23583632-7	2013	U0126 prevents atrazine-induced decrease in LHR and CYP19A1 mRNA levels and estradiol production in the FSH-stimulated granulosa cells.	Atrazine	15-23	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	52-59
23583632-8	2013	ERK1/2 inactivation restores the ability of hCG to induce expression of the ovulatory genes in atrazine-exposed granulosa cells.	Atrazine	95-103	mitogen activated protein kinase 3	Rattus norvegicus	0-6
23583632-8	2013	ERK1/2 inactivation restores the ability of hCG to induce expression of the ovulatory genes in atrazine-exposed granulosa cells.	Atrazine	95-103	hypertrichosis 2 (generalised, congenital)	Homo sapiens	44-47
23583632-10	2013	The results from this study reveal that atrazine does not affect but requires ERK1/2 phosphorylation to cause decrease in the FSH-induced LHR and CYP19A1 mRNA levels and estradiol production in immature granulosa cells, thus compromising ovulation and female fertility.	Atrazine	40-48	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	138-141
23583632-10	2013	The results from this study reveal that atrazine does not affect but requires ERK1/2 phosphorylation to cause decrease in the FSH-induced LHR and CYP19A1 mRNA levels and estradiol production in immature granulosa cells, thus compromising ovulation and female fertility.	Atrazine	40-48	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	146-153
23705103-6	2013	Well-characterized hapten-protein conjugates enabled obtaining highly sensitive anti-atrazine and anti-2,4-D antibodies with IC50 values equal to 12 and 70 ng mL-1 for atrazine and 2,4-D respectively.	Atrazine	85-93	L1 cell adhesion molecule	Mus musculus	159-163
23705103-6	2013	Well-characterized hapten-protein conjugates enabled obtaining highly sensitive anti-atrazine and anti-2,4-D antibodies with IC50 values equal to 12 and 70 ng mL-1 for atrazine and 2,4-D respectively.	Atrazine	168-176	L1 cell adhesion molecule	Mus musculus	159-163
23705103-7	2013	These antibodies were used for developing a fluorescence-based immunoassays format demonstrating a detection limit of atrazine and 2,4-D in standard water samples 2 and 7 ng mL-1, respectively.	Atrazine	118-126	L1 cell adhesion molecule	Mus musculus	174-178
23872617-1	2013	Previous research reported the first case of resistance to mesotrione and other 4-hydroxyphenylpyruvate dioxygenase (HPPD) herbicides in a waterhemp (Amaranthus tuberculatus) population designated MCR (for McLean County mesotrione- and atrazine-resistant).	Atrazine	236-244	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	117-121
24285376-2	2013	Using the C-13 labeled atrazine to detect its residue is effective and essential.	Atrazine	23-31	homeobox C13	Homo sapiens	10-14
24285376-3	2013	This study presents three steps for the synthesis of [(13) C3 ]atrazine, which starts from [(13) C]urea, and results in the incorporation of C-13 atoms at the 1, 3 and 5 positions of the S-triazine ring of atrazine.	Atrazine	63-71	homeobox C13	Homo sapiens	141-145
23638890-4	2013	Results showed that cell-mediated, humoral immunity, and non-specific immune function in the high-dose ATZ group were suppressed; NO release and interferon-gamma(IFN-gamma)/interleukin-4 (IL-4) were also significantly decreased in the high-dose group.	Atrazine	103-106	interferon gamma	Mus musculus	145-171
23376530-6	2013	We also found that the transcript levels of the steroidogenic enzyme genes p450scc, p450 17alpha1 and 17beta-HSD were significantly reduced in the testes of mice exposed to 100 and 200 mg/kg ATZ for 3weeks.	Atrazine	191-194	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	75-82
23376530-7	2013	Given the results of the present study and previous reports, it is possible that ATZ reduces the T concentration in peripubertal male mice by affecting the transcription of steroidogenic genes, such as p450scc, p450 17a1 and 17beta-HSD.	Atrazine	81-84	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	202-209
23358194-10	2013	There was a significant overlap (42 genes) between the 3 and 30 ppb differentially expressed gene lists, with two of these genes (CYP17A1 and SAMHD1) present in all three atrazine treatments.	Atrazine	171-179	cytochrome P450, family 17, subfamily A, polypeptide 1	Danio rerio	130-137
23358194-10	2013	There was a significant overlap (42 genes) between the 3 and 30 ppb differentially expressed gene lists, with two of these genes (CYP17A1 and SAMHD1) present in all three atrazine treatments.	Atrazine	171-179	SAM domain and HD domain 1	Danio rerio	142-148
23197165-0	2013	Atrazine inhibits pulsatile gonadotropin-releasing hormone (GnRH) release without altering GnRH messenger RNA or protein levels in the female rat.	Atrazine	0-8	gonadotropin releasing hormone 1	Rattus norvegicus	28-58
23197165-0	2013	Atrazine inhibits pulsatile gonadotropin-releasing hormone (GnRH) release without altering GnRH messenger RNA or protein levels in the female rat.	Atrazine	0-8	gonadotropin releasing hormone 1	Rattus norvegicus	60-64
23638890-4	2013	Results showed that cell-mediated, humoral immunity, and non-specific immune function in the high-dose ATZ group were suppressed; NO release and interferon-gamma(IFN-gamma)/interleukin-4 (IL-4) were also significantly decreased in the high-dose group.	Atrazine	103-106	interleukin 4	Mus musculus	173-186
23638890-4	2013	Results showed that cell-mediated, humoral immunity, and non-specific immune function in the high-dose ATZ group were suppressed; NO release and interferon-gamma(IFN-gamma)/interleukin-4 (IL-4) were also significantly decreased in the high-dose group.	Atrazine	103-106	interleukin 4	Mus musculus	188-192
22372587-5	2012	The stimulatory action of follicle stimulating hormone (10 ng/mL) on ATZ-induced StAR and CYP11A1 mRNA levels were also prevented by QT.	Atrazine	69-72	steroidogenic acute regulatory protein	Rattus norvegicus	81-85
22858105-2	2012	Interesting increases of bioluminescence signals are recorded for E. coli TV1061 bacteria in the presence of 10 mug/mL atrazine concentration named "high-toxicity bacteria alert" when compared with 1 mug/mL -10 fg/mL atrazine termed "low-toxicity bacteria alert".	Atrazine	119-127	skull morphology 14	Mus musculus	204-210
23022511-6	2012	Rolipram abolished the stimulatory effect of atrazine on cAMP release in both cell types, suggesting that it acts as an inhibitor of PDE4s, isoforms whose mRNA transcripts dominate in pituitary and Leydig cells together with mRNA for PDE8A.	Atrazine	45-53	phosphodiesterase 8A	Rattus norvegicus	234-239
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Atrazine	15-23	latexin	Homo sapiens	186-189
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Atrazine	15-23	latexin	Homo sapiens	186-189
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Atrazine	15-23	latexin	Homo sapiens	186-189
22999709-0	2012	Atrazine disrupts steroidogenesis, VEGF and NO production in swine granulosa cells.	Atrazine	0-8	vascular endothelial growth factor A	Sus scrofa	35-39
22372587-5	2012	The stimulatory action of follicle stimulating hormone (10 ng/mL) on ATZ-induced StAR and CYP11A1 mRNA levels were also prevented by QT.	Atrazine	69-72	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	90-97
22372587-6	2012	Furthermore, ATZ-stimulatory action on AR mRNA was opposed in a dose-dependent manner in the presence of increasing concentrations of QT (10-50 mum).The dislodgement of germ cells from the Sertoli cells monolayer and decrease in SGCs viability was prevented by QT.	Atrazine	13-16	androgen receptor	Rattus norvegicus	39-41
22797327-6	2012	In liver, atrazine increased the activity of GSH-Px, GST, and CYP1A1/2 enzyme, but not lipid peroxidation.	Atrazine	10-18	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-56
22797327-6	2012	In liver, atrazine increased the activity of GSH-Px, GST, and CYP1A1/2 enzyme, but not lipid peroxidation.	Atrazine	10-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-68
22466357-7	2012	Several environmental toxicants activate HR96 including estradiol, pyriproxyfen, chlorpyrifos, atrazine, and methane arsonate.	Atrazine	95-103	Hormone receptor-like in 96	Drosophila melanogaster	41-45
22988636-3	2012	The required delivered O3 dose to achieve 90% removal of atrazine in the tap water from the DTU campus was 3.5 mg/L, which produced 130-170 microg/L BrO3(-).	Atrazine	57-65	SEC14 like lipid binding 2	Homo sapiens	73-76
22674924-4	2012	Additionally, the ATZ-induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) were shifted toward the control values by Kol.	Atrazine	18-21	steroidogenic acute regulatory protein	Rattus norvegicus	104-142
22674924-4	2012	Additionally, the ATZ-induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) were shifted toward the control values by Kol.	Atrazine	18-21	steroidogenic acute regulatory protein	Rattus norvegicus	144-148
22674924-4	2012	Additionally, the ATZ-induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) were shifted toward the control values by Kol.	Atrazine	18-21	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	195-202
22674924-4	2012	Additionally, the ATZ-induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) were shifted toward the control values by Kol.	Atrazine	18-21	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	209-243
22674924-4	2012	Additionally, the ATZ-induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) were shifted toward the control values by Kol.	Atrazine	18-21	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	245-254