PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20798279-0	2010	The effects of single nucleotide polymorphisms in CYP2A13 on metabolism of 5-methoxypsoralen.	5-Methoxypsoralen	75-92	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	50-57
20798279-3	2010	In this study, we examined the effect on 5-MOP metabolism of single nucleotide polymorphisms (SNPs) in CYP2A13.	5-Methoxypsoralen	41-46	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	103-110
20798279-5	2010	In high-performance liquid chromatography analyses of 5-MOP metabolic products, CYP2A13*1 converted 5-MOP into 5-MOP dihydrodiol; K(m) and V(max) values of the reaction were 1.44 +- 0.17 muM and 4.23 +- 0.36 nmol/(min   nmol P450), respectively.	5-Methoxypsoralen	54-59	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	80-87
16277023-0	2005	Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines.	5-Methoxypsoralen	11-28	N-acetyltransferase 1	Rattus norvegicus	50-69
19720161-0	2009	Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen.	5-Methoxypsoralen	71-88	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19720161-7	2009	On the contrary, 5-methoxypsoralen resulted in IL-8 inhibition at 10 microM concentration, without effects on cell proliferation.	5-Methoxypsoralen	17-34	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
16762476-6	2006	The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor.	5-Methoxypsoralen	37-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	130-137
16762476-6	2006	The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor.	5-Methoxypsoralen	37-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	213-220
16762476-6	2006	The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor.	5-Methoxypsoralen	56-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	130-137
16762476-6	2006	The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor.	5-Methoxypsoralen	56-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	213-220
16277023-4	2005	A number of studies have demonstrated that 5-MOP is inhibitory towards mouse and human CYP isoforms, but investigations on the direct effects on NAT activity in laboratory animals and human cancer cells are limited.	5-Methoxypsoralen	43-48	peptidylprolyl isomerase G	Homo sapiens	87-90
8752840-6	1996	We demonstrate that UVA upregulates tyrosinase activity and melanin content with 5-methoxypsoralen at 1 microM.	5-Methoxypsoralen	81-98	tyrosinase	Mus musculus	36-46
15623335-3	2004	A synergistic effect of 5-MOP on the phototoxicity of PPIX, PP(Arg)2 and PP(Phe)2 has been observed.	5-Methoxypsoralen	24-29	arginase 2	Homo sapiens	60-68
15623335-4	2004	The combination of PPIX, PP(Arg)2 and PP(Phe)2 with 0.1-0.5 microM 5-MOP significantly potentiates the phototoxicity of the three porphyrins.	5-Methoxypsoralen	67-72	arginase 2	Homo sapiens	25-33
10868344-7	2000	Both the combined diet and bergapten at 250 ppm caused a weak induction of CYP1A1.	5-Methoxypsoralen	27-36	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	75-81
9039977-1	1997	8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP) and 4,5",8-trimethylpsoralen (TMP) are commonly used in PUVA therapy [psoralen (P) + ultraviolet light A (UVA) irradiation] to treat skin diseases such as psoriasis and vitiligo.	5-Methoxypsoralen	27-44	opioid receptor mu 1	Homo sapiens	48-51
12510833-3	2002	Among the isolates, bergapten showed cyclooxygenase-2 inhibitory activity with an IC50 value of 6.2 microg/ml.	5-Methoxypsoralen	20-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-53
11737987-5	2001	RESULTS: The results showed that the inhibition of quinine 3-hydroxylation (CYP3A4 activity) by bergapten (67%), and quercetin (55%) was greater than naringenin (39%) and naringin (6%), at the same inhibitor concentration of 100 M. The results also demonstrated that the furan ring in the furanocoumarins enhanced the inhibitory effect on CYP3A4 activity.	5-Methoxypsoralen	96-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-82
11737987-5	2001	RESULTS: The results showed that the inhibition of quinine 3-hydroxylation (CYP3A4 activity) by bergapten (67%), and quercetin (55%) was greater than naringenin (39%) and naringin (6%), at the same inhibitor concentration of 100 M. The results also demonstrated that the furan ring in the furanocoumarins enhanced the inhibitory effect on CYP3A4 activity.	5-Methoxypsoralen	96-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	339-345
11737987-7	2001	Of all the chemicals studied, bergapten (5-methoxypsoralen) with the lowest IC50 value (19-36 microM) was the most potent CYP3A4 inhibitor.	5-Methoxypsoralen	30-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	122-128
11737987-7	2001	Of all the chemicals studied, bergapten (5-methoxypsoralen) with the lowest IC50 value (19-36 microM) was the most potent CYP3A4 inhibitor.	5-Methoxypsoralen	41-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	122-128
11737987-9	2001	Bergapten appears to be a potent inhibitor of CYP3A4, and may therefore be primarily responsible for the effect of grapefruit juice on CYP3A4 activity.	5-Methoxypsoralen	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-52
11737987-9	2001	Bergapten appears to be a potent inhibitor of CYP3A4, and may therefore be primarily responsible for the effect of grapefruit juice on CYP3A4 activity.	5-Methoxypsoralen	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-141
9115691-12	1997	The coumarins 5-methoxypsoralen and 4,4"-di-O-methyl scandenin are poor cAK inhibitors (IC50 values 240 and 248 microM, respectively).	5-Methoxypsoralen	14-31	cyclin-dependent kinase 7	Rattus norvegicus	72-75
8379689-1	1993	Human serum albumin is known to be the main carrier of 5-methoxypsoralen (5-MOP) in serum.	5-Methoxypsoralen	55-72	albumin	Homo sapiens	12-19
7855073-4	1994	High concentration of 5-MOP (5 x 10(-5) M) induced a time-dependent increase of tyrosinase activity and melanin content, which was correlated to an increase of both mRNA and protein levels of tyrosinase.	5-Methoxypsoralen	22-27	tyrosinase	Mus musculus	80-90
7855073-4	1994	High concentration of 5-MOP (5 x 10(-5) M) induced a time-dependent increase of tyrosinase activity and melanin content, which was correlated to an increase of both mRNA and protein levels of tyrosinase.	5-Methoxypsoralen	22-27	tyrosinase	Mus musculus	192-202
7855073-6	1994	In addition, 5-MOP stimulated TRP-1 synthesis and induced a dose-dependent decrease of DCT activity without any modification in the expression of the protein.	5-Methoxypsoralen	13-18	tyrosinase-related protein 1	Mus musculus	30-35
7855073-6	1994	In addition, 5-MOP stimulated TRP-1 synthesis and induced a dose-dependent decrease of DCT activity without any modification in the expression of the protein.	5-Methoxypsoralen	13-18	dopachrome tautomerase	Mus musculus	87-90
7544830-0	1994	Induction of cytochrome P-450 by 5-methoxypsoralen in the yeast Saccharomyces cerevisiae.	5-Methoxypsoralen	33-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	13-29
7544830-1	1994	Yeast cells (D7 strain) incubated in the presence of 5-methoxypsoralen (5-MOP) increase the activity of the monooxygenase system cytochrome P-450 dependent (cytochrome P-450 level and 7-ethoxycoumarin-O-diethylase activity).	5-Methoxypsoralen	53-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	129-145
7544830-1	1994	Yeast cells (D7 strain) incubated in the presence of 5-methoxypsoralen (5-MOP) increase the activity of the monooxygenase system cytochrome P-450 dependent (cytochrome P-450 level and 7-ethoxycoumarin-O-diethylase activity).	5-Methoxypsoralen	53-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-173
7544830-1	1994	Yeast cells (D7 strain) incubated in the presence of 5-methoxypsoralen (5-MOP) increase the activity of the monooxygenase system cytochrome P-450 dependent (cytochrome P-450 level and 7-ethoxycoumarin-O-diethylase activity).	5-Methoxypsoralen	72-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	129-145
7544830-1	1994	Yeast cells (D7 strain) incubated in the presence of 5-methoxypsoralen (5-MOP) increase the activity of the monooxygenase system cytochrome P-450 dependent (cytochrome P-450 level and 7-ethoxycoumarin-O-diethylase activity).	5-Methoxypsoralen	72-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-173
7544830-4	1994	The capacity of 5-MOP to induce the cytochrome P-450 system in eukaryotic cells, in which it is known to be involved in the metabolism of the psoralen, may decrease the availability of the compound for photo-induced genotoxic reactions, which may explain the good tolerance in patients.	5-Methoxypsoralen	16-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-52
8461033-5	1993	The furanocoumarins bergapten (5-methoxypsoralen), isopimpinellin (5,8-dimethoxypsoralen), imperatorin and sphondin also effectively inhibited mouse COH activity (IC50 values 19-40 microM).	5-Methoxypsoralen	20-29	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	149-152
8461033-5	1993	The furanocoumarins bergapten (5-methoxypsoralen), isopimpinellin (5,8-dimethoxypsoralen), imperatorin and sphondin also effectively inhibited mouse COH activity (IC50 values 19-40 microM).	5-Methoxypsoralen	31-48	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	149-152
8379689-1	1993	Human serum albumin is known to be the main carrier of 5-methoxypsoralen (5-MOP) in serum.	5-Methoxypsoralen	74-79	albumin	Homo sapiens	12-19
6531023-3	1984	Oral 5-methoxypsoralen (5-MOP) has been evaluated as an alternative drug because it is less erythemogenic and thus reduces the danger of accidental over-exposure.	5-Methoxypsoralen	5-22	opioid receptor mu 1	Homo sapiens	26-29
34970434-10	2021	Bergapten inhibited protein denaturation with IC50 values of 5.34 +- 0.30 mug/ml and 12.18 +- 0.20 mug/ml in the heat-treated egg albumin and bovine serum albumin denaturation experiments, respectively.	5-Methoxypsoralen	0-9	albumin	Homo sapiens	149-162
34428446-0	2021	Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer"s disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/beta-catenin, AMPK/mTOR signaling pathways.	5-Methoxypsoralen	14-23	thymoma viral proto-oncogene 1	Mus musculus	132-135
34428446-0	2021	Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer"s disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/beta-catenin, AMPK/mTOR signaling pathways.	5-Methoxypsoralen	14-23	wingless-type MMTV integration site family, member 3A	Mus musculus	137-140
34428446-0	2021	Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer"s disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/beta-catenin, AMPK/mTOR signaling pathways.	5-Methoxypsoralen	14-23	catenin (cadherin associated protein), beta 1	Mus musculus	141-153
34428446-0	2021	Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer"s disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/beta-catenin, AMPK/mTOR signaling pathways.	5-Methoxypsoralen	14-23	mechanistic target of rapamycin kinase	Mus musculus	160-164
34428446-5	2021	Administration of TAD or BG at doses of 20 and 25 mg/kg, respectively, for 21 consecutive days attenuated STZ-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the Morris water maze and object recognition tests paralleled by reduction in Abeta expression by 79 and 89% and tau hyperphosphorylation by 60 and 61%, respectively.	5-Methoxypsoralen	25-27	amyloid beta (A4) precursor protein	Mus musculus	281-286
34428446-7	2021	Furthermore, TAD and BG boosted hippocampal levels of cGMP, PKG, Wnt3a, and AMPK and reduced expression of beta-catenin and mTOR by 74% and 51%, respectively.	5-Methoxypsoralen	21-23	wingless-type MMTV integration site family, member 3A	Mus musculus	65-70
34428446-7	2021	Furthermore, TAD and BG boosted hippocampal levels of cGMP, PKG, Wnt3a, and AMPK and reduced expression of beta-catenin and mTOR by 74% and 51%, respectively.	5-Methoxypsoralen	21-23	catenin (cadherin associated protein), beta 1	Mus musculus	107-119
34428446-7	2021	Furthermore, TAD and BG boosted hippocampal levels of cGMP, PKG, Wnt3a, and AMPK and reduced expression of beta-catenin and mTOR by 74% and 51%, respectively.	5-Methoxypsoralen	21-23	mechanistic target of rapamycin kinase	Mus musculus	124-128
34428446-8	2021	TAD and BG also halted neuroinflammation by reducing IL-23 and IL-27 levels, as well as protein expression of NF-kappaB by 62% & 61%, respectively.	5-Methoxypsoralen	8-10	interleukin 23, alpha subunit p19	Mus musculus	53-58
34428446-8	2021	TAD and BG also halted neuroinflammation by reducing IL-23 and IL-27 levels, as well as protein expression of NF-kappaB by 62% & 61%, respectively.	5-Methoxypsoralen	8-10	interleukin 27	Mus musculus	63-68
35565964-4	2022	The results also showed that bergapten promotes the phosphorylation of Akt at Ser 473 and glycogen synthase kinase-3beta at Ser 9.	5-Methoxypsoralen	29-38	thymoma viral proto-oncogene 1	Mus musculus	71-74
35565964-4	2022	The results also showed that bergapten promotes the phosphorylation of Akt at Ser 473 and glycogen synthase kinase-3beta at Ser 9.	5-Methoxypsoralen	29-38	glycogen synthase kinase 3 beta	Mus musculus	90-120
2127639-1	1990	Psoralens (8-methoxypsoralen, 5-methoxypsoralen and 4,5,8-trimethylpsoralen) stimulate mouse melanoma cell (S91 and B16/F10) tyrosinase activity in vitro in a dose-related manner.	5-Methoxypsoralen	30-47	tyrosinase	Mus musculus	125-135
34455773-9	2021	Furthermore, bergapten decreased the expression of inflammatory markers, such as nuclear factor kappa B (NF-Kb) and tumor necrosis factor-alpha (TNF-alpha), as evidenced by immunohistochemistry and ELISA.	5-Methoxypsoralen	13-22	nuclear factor kappa B subunit 1	Rattus norvegicus	81-103
34455773-9	2021	Furthermore, bergapten decreased the expression of inflammatory markers, such as nuclear factor kappa B (NF-Kb) and tumor necrosis factor-alpha (TNF-alpha), as evidenced by immunohistochemistry and ELISA.	5-Methoxypsoralen	13-22	nuclear factor kappa B subunit 1	Rattus norvegicus	105-110
34455773-9	2021	Furthermore, bergapten decreased the expression of inflammatory markers, such as nuclear factor kappa B (NF-Kb) and tumor necrosis factor-alpha (TNF-alpha), as evidenced by immunohistochemistry and ELISA.	5-Methoxypsoralen	13-22	tumor necrosis factor	Rattus norvegicus	116-143
34455773-9	2021	Furthermore, bergapten decreased the expression of inflammatory markers, such as nuclear factor kappa B (NF-Kb) and tumor necrosis factor-alpha (TNF-alpha), as evidenced by immunohistochemistry and ELISA.	5-Methoxypsoralen	13-22	tumor necrosis factor	Rattus norvegicus	145-154
35565964-5	2022	Moreover, bergapten increased the content of beta-catenin in the cell cytoplasm and nucleus by reducing the phosphorylated beta-catenin (p-beta-catenin) content.	5-Methoxypsoralen	10-19	catenin (cadherin associated protein), beta 1	Mus musculus	45-57
35565964-5	2022	Moreover, bergapten increased the content of beta-catenin in the cell cytoplasm and nucleus by reducing the phosphorylated beta-catenin (p-beta-catenin) content.	5-Methoxypsoralen	10-19	catenin (cadherin associated protein), beta 1	Mus musculus	123-135
35565964-5	2022	Moreover, bergapten increased the content of beta-catenin in the cell cytoplasm and nucleus by reducing the phosphorylated beta-catenin (p-beta-catenin) content.	5-Methoxypsoralen	10-19	catenin (cadherin associated protein), beta 1	Mus musculus	139-151
35565964-6	2022	The results also indicated that bergapten regulates melanogenesis by upregulating the phosphorylation of p38 and JNK-mitogen-activated protein kinase.	5-Methoxypsoralen	32-41	mitogen-activated protein kinase 14	Mus musculus	105-108
35565964-6	2022	The results also indicated that bergapten regulates melanogenesis by upregulating the phosphorylation of p38 and JNK-mitogen-activated protein kinase.	5-Methoxypsoralen	32-41	mitogen-activated protein kinase 8	Mus musculus	113-116
35565964-7	2022	Taken together, these findings suggest that the regulation of melanogenesis by bergapten may be mediated by the beta-catenin and MAPK signaling pathways and that bergapten might provide new insights into the pathogenesis of pigmented diseases.	5-Methoxypsoralen	79-88	catenin (cadherin associated protein), beta 1	Mus musculus	112-124
3150000-1	1988	The relative affinity of 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) towards beta-cyclodextrin, a good model for the study of lipophilic interactions in biological systems and a potential drug carrier, has been investigated using spectroscopic and chromatographic methods.	5-Methoxypsoralen	25-42	opioid receptor mu 1	Homo sapiens	46-49
3735138-3	1986	CO-binding cytochrome P-450 decreased when hepatic microsomes were incubated for 10 min with an NADPH-generating system and 8-methoxypsoralen, 5-methoxypsoralen or psoralen (400 microM), but remained unchanged with trioxsalen (400 microM).	5-Methoxypsoralen	143-160	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	11-27
6849820-1	1983	Hairless albino mice have been treated with topically applied 8-methoxypsoralen and 5-methoxypsoralen at two concentrations and exposed to solar simulated radiation.	5-Methoxypsoralen	84-101	lysine demethylase and nuclear receptor corepressor	Mus musculus	0-8
32676972-8	2021	Therefore, it may be suggested that heraclin exerts beneficial effects against reserpine-induced musculoskeletal pain disorder possibly through the attenuation of NGFR-mediated pain and inflammatory signaling.	5-Methoxypsoralen	36-44	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	163-167
32637779-1	2020	The current investigation was aimed at in vivo MAOA inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots of Angelica archangelica.	5-Methoxypsoralen	96-105	monoamine oxidase A	Mus musculus	47-51
32862473-2	2021	Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling.	5-Methoxypsoralen	67-84	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	258-263
32862473-2	2021	Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling.	5-Methoxypsoralen	67-84	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	265-308
32862473-2	2021	Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling.	5-Methoxypsoralen	67-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	314-319
32862473-2	2021	Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling.	5-Methoxypsoralen	67-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	321-366
33283118-6	2020	The gut microbial conversion of xanthotoxin (1) and bergapten (2) with the MRG-PMF1 strain resulted in the production of xanthotoxol (7) and bergaptol (8), respectively, due to the methyl aryl ether cleavage by O-methyltransferase.	5-Methoxypsoralen	52-61	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	75-78
33283118-6	2020	The gut microbial conversion of xanthotoxin (1) and bergapten (2) with the MRG-PMF1 strain resulted in the production of xanthotoxol (7) and bergaptol (8), respectively, due to the methyl aryl ether cleavage by O-methyltransferase.	5-Methoxypsoralen	52-61	polyamine modulated factor 1	Homo sapiens	79-83
32885074-3	2020	Previous studies on bergapten have explored mainly its in vitro anti-inflammatory activities which include suppression of the expression and release of pro-inflammatory cytokines such as TNF-alpha and interleukins as well as prostaglandins.	5-Methoxypsoralen	20-29	tumor necrosis factor	Rattus norvegicus	187-196
32637779-3	2020	The molecular docking results displayed that bergapten has a maximum affinity for MAOA, followed by angelicin and scopoletin.	5-Methoxypsoralen	45-54	monoamine oxidase A	Mus musculus	82-86
32637779-7	2020	Biochemical examination of the brain tissue indicated that bergapten has maximum MAOA inhibitory activity while scopoletin fails to inhibit brain MAOA.	5-Methoxypsoralen	59-68	monoamine oxidase A	Mus musculus	81-85
30875838-3	2019	Bone mineral density (BMD) and microarchitecture quality were significantly reduced in the diabetic control group; however, both bergapten and methoxsalen reversed serum osteocalcin, bone-alkaline phosphatase and femur BMD.	5-Methoxypsoralen	129-138	bone gamma-carboxyglutamate protein 2	Mus musculus	170-181
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	heat shock protein 5	Mus musculus	147-152
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	activating transcription factor 4	Mus musculus	154-158
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	DNA-damage inducible transcript 3	Mus musculus	160-164
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	168-172
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	173-177
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	eukaryotic translation initiation factor 2A	Mus musculus	184-193
32239867-6	2019	Compared with TCP group, the damages of MLO-Y4 and cell apoptosis in bergapten treated groups were decrease obviously (P<0.05), the expressions of GRP78, AFT4, CHOP, p-PERK/PERK and p-eIF2alpha/eIF2alpha were down-regulated remarkably (P<0.05).	5-Methoxypsoralen	69-78	eukaryotic translation initiation factor 2A	Mus musculus	194-203
30953227-0	2019	Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.	5-Methoxypsoralen	0-9	poly (ADP-ribose) polymerase family, member 1	Mus musculus	123-127
30953227-0	2019	Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.	5-Methoxypsoralen	0-9	nitric oxide synthase 2, inducible	Mus musculus	129-133
30953227-0	2019	Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.	5-Methoxypsoralen	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	135-140
30953227-7	2019	Bergapten also significantly decreased the levels of TNF-alpha and IL-6 and the expression of PARP, COX-2 and iNOS in the spine.	5-Methoxypsoralen	0-9	tumor necrosis factor	Mus musculus	53-62
30953227-7	2019	Bergapten also significantly decreased the levels of TNF-alpha and IL-6 and the expression of PARP, COX-2 and iNOS in the spine.	5-Methoxypsoralen	0-9	interleukin 6	Mus musculus	67-71
30953227-7	2019	Bergapten also significantly decreased the levels of TNF-alpha and IL-6 and the expression of PARP, COX-2 and iNOS in the spine.	5-Methoxypsoralen	0-9	poly (ADP-ribose) polymerase family, member 1	Mus musculus	94-98
30953227-7	2019	Bergapten also significantly decreased the levels of TNF-alpha and IL-6 and the expression of PARP, COX-2 and iNOS in the spine.	5-Methoxypsoralen	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	100-105
30953227-7	2019	Bergapten also significantly decreased the levels of TNF-alpha and IL-6 and the expression of PARP, COX-2 and iNOS in the spine.	5-Methoxypsoralen	0-9	nitric oxide synthase 2, inducible	Mus musculus	110-114
31064179-13	2019	Bergapten also attenuated pro-inflammatory cytokines (TNFalpha and IL-1beta), oxidative stress, and expression of NFkB, COX-2, and iNOS.	5-Methoxypsoralen	0-9	tumor necrosis factor	Rattus norvegicus	54-62
31064179-13	2019	Bergapten also attenuated pro-inflammatory cytokines (TNFalpha and IL-1beta), oxidative stress, and expression of NFkB, COX-2, and iNOS.	5-Methoxypsoralen	0-9	interleukin 1 alpha	Rattus norvegicus	67-75
31064179-13	2019	Bergapten also attenuated pro-inflammatory cytokines (TNFalpha and IL-1beta), oxidative stress, and expression of NFkB, COX-2, and iNOS.	5-Methoxypsoralen	0-9	nuclear factor kappa B subunit 1	Rattus norvegicus	114-118
31064179-13	2019	Bergapten also attenuated pro-inflammatory cytokines (TNFalpha and IL-1beta), oxidative stress, and expression of NFkB, COX-2, and iNOS.	5-Methoxypsoralen	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	120-125
31064179-13	2019	Bergapten also attenuated pro-inflammatory cytokines (TNFalpha and IL-1beta), oxidative stress, and expression of NFkB, COX-2, and iNOS.	5-Methoxypsoralen	0-9	nitric oxide synthase 2	Rattus norvegicus	131-135
31037830-0	2019	Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway.	5-Methoxypsoralen	0-9	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	54-60
31037830-0	2019	Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway.	5-Methoxypsoralen	0-9	ATM serine/threonine kinase	Homo sapiens	61-64
30628674-0	2019	Bergapten induces G1 arrest of non-small cell lung cancer cells, associated with the p53-mediated cascade.	5-Methoxypsoralen	0-9	tumor protein p53	Homo sapiens	85-88
30628674-11	2019	Overall, these results suggested that bergapten may inhibit cell viability and trigger G1 arrest and apoptosis in A549 and NCI-H460 cells, which may be attributed to the activation of p53-mediated cascades.	5-Methoxypsoralen	38-47	tumor protein p53	Homo sapiens	184-187
28101244-10	2016	The coumarin derivative 5-methoxypsoralen present in celery extract did not solely to the inhibition of CYP2A5/6 activity.	5-Methoxypsoralen	24-41	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	104-110
30579598-0	2019	Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-kappaB and JNK signaling pathways.	5-Methoxypsoralen	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	21-26
30579598-6	2019	Additionally, BP specifically inhibited RANKL-induced NF-kappaB and JNK signaling,but did not suppress p38 and ERK.	5-Methoxypsoralen	14-16	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	40-45
30579598-7	2019	At the mRNA level, BP inhibits the OC-associated transcription factor NFATc1 and c-fos, thereby affecting the expression of OC differentiation-related genes.	5-Methoxypsoralen	19-21	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	70-76
30579598-7	2019	At the mRNA level, BP inhibits the OC-associated transcription factor NFATc1 and c-fos, thereby affecting the expression of OC differentiation-related genes.	5-Methoxypsoralen	19-21	FBJ osteosarcoma oncogene	Mus musculus	81-86
30227322-0	2018	Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.	5-Methoxypsoralen	0-9	AKT serine/threonine kinase 1	Homo sapiens	63-66
30227322-0	2018	Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.	5-Methoxypsoralen	0-9	myosin regulatory light chain interacting protein	Homo sapiens	71-75
30227322-0	2018	Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.	5-Methoxypsoralen	0-9	low density lipoprotein receptor	Homo sapiens	76-80
29079042-0	2017	ABC-transporter blockage mediated by xanthotoxin and bergapten is the major pathway for chemosensitization of multidrug-resistant cancer cells.	5-Methoxypsoralen	53-62	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-15
21496221-10	2011	CONCLUSIONS: These obtained results clearly indicate that bergapten and citropten are strong inhibitors of IL-8 expression and could be proposed for further studies to verify possible anti-inflammatory properties to reduce lung inflammation in CF patients.	5-Methoxypsoralen	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
26188800-8	2015	Furthermore, WNT/beta-catenin signaling was activated in the presence of BP in BMSCs in osteogenic culture.	5-Methoxypsoralen	73-75	catenin (cadherin associated protein), beta 1	Mus musculus	17-29
26188800-9	2015	Finally, BP promoted differentiation of BMSCs into osteoblasts by up-regulation of the WNT/beta-catenin pathway.	5-Methoxypsoralen	9-11	catenin (cadherin associated protein), beta 1	Mus musculus	91-103
24732412-4	2014	Of the drugs screened, only the potent CYP1A2 inhibitor 5-methoxypsoralen impaired the 6-melatonin hydroxylation at pharmacologically relevant concentrations, and is likely to lead to clinical interactions; diazepam, tamoxifen and acetaminophen (paracetamol) did not impair the metabolic conversion of melatonin to 6-sulphatoxymelatonin at concentrations attained following therapeutic administration.	5-Methoxypsoralen	56-73	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
27656241-0	2016	Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-alpha/PI3K/Akt-Signaling Pathways in HepG2 Cells.	5-Methoxypsoralen	14-31	insulin	Homo sapiens	43-50
27656241-0	2016	Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-alpha/PI3K/Akt-Signaling Pathways in HepG2 Cells.	5-Methoxypsoralen	14-31	estrogen receptor 1	Homo sapiens	70-78
27656241-0	2016	Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-alpha/PI3K/Akt-Signaling Pathways in HepG2 Cells.	5-Methoxypsoralen	14-31	AKT serine/threonine kinase 1	Homo sapiens	84-87
23053665-0	2012	Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination.	5-Methoxypsoralen	0-9	SMAD family member 4	Homo sapiens	62-67
23053665-5	2012	Taking into account our previous published data we wanted to study the effect of 5-Methoxypsoralen (bergapten) on ERalpha and on TGF-beta pathway.	5-Methoxypsoralen	81-98	estrogen receptor 1	Homo sapiens	114-121
23053665-5	2012	Taking into account our previous published data we wanted to study the effect of 5-Methoxypsoralen (bergapten) on ERalpha and on TGF-beta pathway.	5-Methoxypsoralen	81-98	transforming growth factor beta 1	Homo sapiens	129-137
23053665-6	2012	We reported that bergapten, a coumarin containing compound, effectively depletes ERalpha in MCF-7 breast cancer sensitive cells and in tamoxifen-resistant clone.	5-Methoxypsoralen	17-26	estrogen receptor 1	Homo sapiens	81-88