PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
13567236-0	1958	[Effect of vitamin B12 on coproporphyrin in lead poisoning].	Coproporphyrins	26-40	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
1164515-1	1975	Rabbit hemopexin forms equimolar complexes in vitro with the I and III isomers of both coproporphyrin and uroporphyrin.	Coproporphyrins	87-101	hemopexin	Oryctolagus cuniculus	7-16
1164515-3	1975	Results of competitive binding experiments suggest that all four porphyrins bind at the heme-binding site of hemopexin, and that the relative affinity of rabbit hemopexin for these porphyrins is: deuteroheme greater than coproporphyrin I or III greater than uroporphyrin I or III.	Coproporphyrins	221-235	hemopexin	Oryctolagus cuniculus	161-170
1164515-4	1975	These findings provide further evidence that hemopexin may function as a transport protein for circulating coproporphyrins as well as for heme.	Coproporphyrins	107-122	hemopexin	Oryctolagus cuniculus	45-54
3126696-4	1987	The protoporphyrin:coproporphyrin ratio observed was found to correlate with ferrochelatase-inhibitory activity.	Coproporphyrins	19-33	ferrochelatase	Gallus gallus	77-91
6883207-5	1983	Coproporphyrin was the major porphyrin to accumulate in response to allylisopropylacetamide, aromatic amides, and steroids, a result suggesting inhibition of coproporphyrinogen oxidase.	Coproporphyrins	0-14	coproporphyrinogen oxidase	Gallus gallus	158-184
661926-2	1978	The mean uroporphyrinogen decarboxylase activity was lower in liver from seven male patients (9.0 pmol of coproporphyrin per minute per milligram of protein) than in 12 controls, including seven with alcoholic liver disease (22.3 pmol per minute per milligram; P less than 0.05).	Coproporphyrins	106-120	uroporphyrinogen decarboxylase	Homo sapiens	9-39
833440-1	1977	Concentrations of hemopexin, a porphyrin-binding serum protein synthesized exclusively in the liver, increased significantly and concomitantly with levels of erythrocyte and liver protoporphyrin and coproporphyrin in mice made porphyric with 1% griseofulvin in the feed.	Coproporphyrins	199-213	hemopexin	Mus musculus	18-27
29747517-0	2018	A fully automated and validated human plasma LC-MS/MS assay for endogenous OATP biomarkers coproporphyrin-I and coproporphyrin-III.	Coproporphyrins	91-105	solute carrier organic anion transporter family member 1A2	Homo sapiens	75-79
33048456-4	2021	This work investigated the utility of OATP1B1/1B3 endogenous biomarkers, coproporphyrin (CP)-I and CP-III, to assess clinical inhibition of OATP1B1/1B3 and potentially eliminate the need for prospective clinical drug-drug interaction (DDI) studies.	Coproporphyrins	73-87	solute carrier organic anion transporter family member 1B1	Homo sapiens	38-49
32407928-5	2020	OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins.	Coproporphyrins	133-148	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
32407928-5	2020	OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins.	Coproporphyrins	133-148	solute carrier organic anion transporter family member 1B3	Homo sapiens	12-19
29317194-6	2018	PBGD activity was measured in erythrocytes by quantifying formation of coproporphyrin or uroporphyrin by the enzyme using porphobilinogen (PBG) as a substrate and fluorimetry for detection.	Coproporphyrins	71-85	hydroxymethylbilane synthase	Homo sapiens	0-4
29786857-0	2018	Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.	Coproporphyrins	84-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	10-21
29786857-10	2018	Retrospectively, the endogenous biomarkers of OATP1B1/1B3, coproporphyrin I and III, were also measured and showed changes comparable to those of pravastatin, indicating their utility in detecting weak inhibition of OATP1B1/1B3 in the clinical setting.	Coproporphyrins	59-73	solute carrier organic anion transporter family member 1B1	Homo sapiens	46-57
28864672-2	2017	However, for the recently discovered coproporphyrin-dependent pathway, ferrochelatase catalyses the penultimate reaction where ferrous iron is inserted into coproporphyrin III.	Coproporphyrins	37-51	AT695_RS08245	Staphylococcus aureus	71-85
29241088-1	2018	Coproporphyrins are proposed as endogenous biomarkers of hepatic Organic Anion Transporting Polypeptide (OATP)1B functional activity.	Coproporphyrins	0-15	solute carrier organic anion transporter family member 1A2	Homo sapiens	105-109
28864672-3	2017	Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylococcus aureus are known to be inhibited by elevated iron concentrations.	Coproporphyrins	125-139	AT695_RS08245	Staphylococcus aureus	0-14
28532626-7	2017	Interestingly, coproporphyrin isomer I, a prototypical substrate of MRP2, also belonged to our final list although it was not significantly discriminant on its own.	Coproporphyrins	15-29	ATP binding cassette subfamily C member 2	Homo sapiens	68-72
9674964-8	1998	The dose-response increase of coproporphyrin secretion accompanied by the depression of CO activity supports the suggestion that lead causes CO inhibition, as observed in this cellular model.	Coproporphyrins	30-44	coproporphyrinogen oxidase	Homo sapiens	141-143
28576766-0	2017	Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.	Coproporphyrins	122-137	solute carrier organic anion transporter family member 1A2	Homo sapiens	162-166
28576766-2	2017	Previously, we demonstrated that coproporphyrins (CPs) I and III are appropriate clinical markers to evaluate OATP inhibition and recapitulate clinical drug-drug interactions (DDIs).	Coproporphyrins	33-48	solute carrier organic anion transporter family member 1A2	Homo sapiens	110-114
28576766-2	2017	Previously, we demonstrated that coproporphyrins (CPs) I and III are appropriate clinical markers to evaluate OATP inhibition and recapitulate clinical drug-drug interactions (DDIs).	Coproporphyrins	50-53	solute carrier organic anion transporter family member 1A2	Homo sapiens	110-114
28576766-11	2017	Since these endogenous markers can be monitored in conjunction with pharmacokinetics analysis, the CPs and fatty acid dicarboxylates, either alone or in combination, offer promise of earlier diagnosis and risk stratification for OATP-mediated DDIs.	Coproporphyrins	99-102	solute carrier organic anion transporter family member 1A2	Homo sapiens	229-233
28196047-1	2017	BACKGROUND: Multidrug resistance protein-2 encoded by the ABCC2 gene (MRP2/ABCC2), an efflux transporter expressed at the proximal renal tubule, is rate-limiting for urine excretion of coproporphyrin (UCP) isomers I and III, translating in high UCP [I/(I + III)] ratio in MRP2-deficient patients presenting with the Dubin-Johnson Syndrome.	Coproporphyrins	185-199	ATP binding cassette subfamily C member 2	Homo sapiens	58-63
28196047-1	2017	BACKGROUND: Multidrug resistance protein-2 encoded by the ABCC2 gene (MRP2/ABCC2), an efflux transporter expressed at the proximal renal tubule, is rate-limiting for urine excretion of coproporphyrin (UCP) isomers I and III, translating in high UCP [I/(I + III)] ratio in MRP2-deficient patients presenting with the Dubin-Johnson Syndrome.	Coproporphyrins	185-199	ATP binding cassette subfamily C member 2	Homo sapiens	70-74
28196047-1	2017	BACKGROUND: Multidrug resistance protein-2 encoded by the ABCC2 gene (MRP2/ABCC2), an efflux transporter expressed at the proximal renal tubule, is rate-limiting for urine excretion of coproporphyrin (UCP) isomers I and III, translating in high UCP [I/(I + III)] ratio in MRP2-deficient patients presenting with the Dubin-Johnson Syndrome.	Coproporphyrins	185-199	ATP binding cassette subfamily C member 2	Homo sapiens	75-80
26907622-0	2016	Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.	Coproporphyrins	0-15	ornithine aminotransferase pseudogene 1	Homo sapiens	51-56
26907622-4	2016	Active uptake of CPs I and III was observed in human embryonic kidney (HEK) 293 cells singly expressing human OATP1B1 (hOATP1B1), hOATP1B3, cynomolgus monkey OATP1B1 (cOATP1B1), or cOATP1B3, as well as human and monkey hepatocytes.	Coproporphyrins	17-20	solute carrier organic anion transporter family member 1B1	Homo sapiens	110-117
26907622-4	2016	Active uptake of CPs I and III was observed in human embryonic kidney (HEK) 293 cells singly expressing human OATP1B1 (hOATP1B1), hOATP1B3, cynomolgus monkey OATP1B1 (cOATP1B1), or cOATP1B3, as well as human and monkey hepatocytes.	Coproporphyrins	17-20	solute carrier organic anion transporter family member 1B1	Homo sapiens	119-127
26907622-4	2016	Active uptake of CPs I and III was observed in human embryonic kidney (HEK) 293 cells singly expressing human OATP1B1 (hOATP1B1), hOATP1B3, cynomolgus monkey OATP1B1 (cOATP1B1), or cOATP1B3, as well as human and monkey hepatocytes.	Coproporphyrins	17-20	solute carrier organic anion transporter family member 1B3	Homo sapiens	130-138
26907622-4	2016	Active uptake of CPs I and III was observed in human embryonic kidney (HEK) 293 cells singly expressing human OATP1B1 (hOATP1B1), hOATP1B3, cynomolgus monkey OATP1B1 (cOATP1B1), or cOATP1B3, as well as human and monkey hepatocytes.	Coproporphyrins	17-20	solute carrier organic anion transporter family member 1B1	Homo sapiens	120-127
26907622-8	2016	In Oatp1a/1b gene cluster knockout mice (Oatp1a/1b(-/-)), CPs in plasma and urine were significantly increased compared with wild-type animals (7.1- to 18.4-fold; P < 0.001), which were also in agreement with the changes in plasma RSV exposure (14.6-fold increase).	Coproporphyrins	58-61	solute carrier organic anion transporter family, member 1a1	Mus musculus	3-11
24433481-1	2014	AIMS: The urinary coproporphyrin I/(I + III) ratio may be a surrogate for MRP2 activity.	Coproporphyrins	18-32	ATP binding cassette subfamily C member 2	Homo sapiens	74-78
21541183-0	2011	Urinary elimination of coproporphyrins is dependent on ABCC2 polymorphisms and represents a potential biomarker of MRP2 activity in humans.	Coproporphyrins	23-38	ATP binding cassette subfamily C member 2	Homo sapiens	55-60
21541183-0	2011	Urinary elimination of coproporphyrins is dependent on ABCC2 polymorphisms and represents a potential biomarker of MRP2 activity in humans.	Coproporphyrins	23-38	ATP binding cassette subfamily C member 2	Homo sapiens	115-119
21541183-2	2011	Patients with Dubin-Johnson syndrome due to mutation in ABCC2 gene have elevated urinary coproporphyrin ratio (UCP I/(I + III)).	Coproporphyrins	89-103	ATP binding cassette subfamily C member 2	Homo sapiens	56-61
19836315-1	2009	We describe here the development of a high-performance liquid chromatography (HPLC) method for quantitative determination of the ratio of isomers I and III of urinary coproporphyrin [the UCP I/(I+III) ratio], which is used for the diagnosis of Dubin-Johnson syndrome (DJS).	Coproporphyrins	167-181	uncoupling protein 1	Homo sapiens	187-190
15946643-4	2005	Treatment with both insulin and glucagon resulted in additive increases in uroporphyrin, but not coproporphyrin.	Coproporphyrins	97-111	insulin	Gallus gallus	20-27
12770916-0	2003	Conformational dynamics and temperature dependence of photoinduced electron transfer within self-assembled coproporphyrin:cytochrome c complexes.	Coproporphyrins	107-121	cytochrome c, somatic	Equus caballus	122-134
12770916-1	2003	The focus of the present study is to better understand the complex factors influencing intermolecular electron transfer (ET) in biological molecules using a model system involving free-base coproporphyrin (COP) complexed with horse heart cytochrome c (Cc).	Coproporphyrins	190-204	cytochrome c, somatic	Equus caballus	238-250
12770916-1	2003	The focus of the present study is to better understand the complex factors influencing intermolecular electron transfer (ET) in biological molecules using a model system involving free-base coproporphyrin (COP) complexed with horse heart cytochrome c (Cc).	Coproporphyrins	206-209	cytochrome c, somatic	Equus caballus	238-250
11939554-3	2002	Using the published data on the interaction between human serum albumin (HSA) and three kinds of porphyrin (coproporphyrin (CP), uroporphyrin I (UP) and protoporphyrin (PP)), a further study on their binding was carried out.	Coproporphyrins	108-122	albumin	Homo sapiens	58-71
10350189-6	1999	The direct relationships between enzyme activities and urinary porphyrins, suggest that the increased porphyrin excretion was related to PBG-D, whereas the increased URO-D activity would enhance coproporphyrin synthesis and excretion at the expense of uroporphyrin.	Coproporphyrins	195-209	uroporphyrinogen decarboxylase	Homo sapiens	166-171
10211628-1	1999	OBJECTIVES: Investigation of the metabolism of the four urinary coproporphyrin isomers I-IV in the extremely rare 5-aminolevulinic acid dehydratase (ALAD) deficiency porphyria (syn.	Coproporphyrins	64-78	synemin	Homo sapiens	177-180
26920082-1	2016	BACKGROUND: The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I + III)]] serves as a biomarker of the ATP-binding cassette, sub-family C, member 2 (ABCC2) function.	Coproporphyrins	33-47	ATP binding cassette subfamily C member 2	Homo sapiens	147-191
26920082-1	2016	BACKGROUND: The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I + III)]] serves as a biomarker of the ATP-binding cassette, sub-family C, member 2 (ABCC2) function.	Coproporphyrins	33-47	ATP binding cassette subfamily C member 2	Homo sapiens	193-198
26920082-1	2016	BACKGROUND: The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I + III)]] serves as a biomarker of the ATP-binding cassette, sub-family C, member 2 (ABCC2) function.	Coproporphyrins	73-87	ATP binding cassette subfamily C member 2	Homo sapiens	147-191
26920082-1	2016	BACKGROUND: The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I + III)]] serves as a biomarker of the ATP-binding cassette, sub-family C, member 2 (ABCC2) function.	Coproporphyrins	73-87	ATP binding cassette subfamily C member 2	Homo sapiens	193-198
26383540-0	2016	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	Coproporphyrins	68-83	solute carrier organic anion transporter family member 1A2	Homo sapiens	0-38
26383540-0	2016	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	Coproporphyrins	68-83	solute carrier organic anion transporter family member 1A2	Homo sapiens	40-44
26383540-3	2016	Inactivating mutations of both OATP1B1 and OATP1B3 alleles lead to Rotor syndrome, a disease characterized by coproporphyrinuria, an elevated urinary excretion of coproporphyrins I and III.	Coproporphyrins	163-178	solute carrier organic anion transporter family member 1B1	Homo sapiens	31-38
26383540-3	2016	Inactivating mutations of both OATP1B1 and OATP1B3 alleles lead to Rotor syndrome, a disease characterized by coproporphyrinuria, an elevated urinary excretion of coproporphyrins I and III.	Coproporphyrins	163-178	solute carrier organic anion transporter family member 1B3	Homo sapiens	43-50
26383540-4	2016	It was hypothesized that transport of coproporphyrins I and III was mediated by OATP1B1 and OATP1B3.	Coproporphyrins	38-53	solute carrier organic anion transporter family member 1B1	Homo sapiens	80-87
26383540-4	2016	It was hypothesized that transport of coproporphyrins I and III was mediated by OATP1B1 and OATP1B3.	Coproporphyrins	38-53	solute carrier organic anion transporter family member 1B3	Homo sapiens	92-99
26383540-8	2016	OATP1B1-mediated transport of coproporphyrins I and III (Km = 0.13 and 0.22 microM, respectively), as did OATP1B3 (Km = 3.25 and 4.61 microM, respectively).	Coproporphyrins	30-45	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
26383540-11	2016	The specificity of coproporphyrin transport was also investigated where OATP2B1 demonstrated meaningful transport of coproporphyrin III (Km = 0.31 microM), while OCT1, OCT2, OAT1, OAT3 and NTCP were negative for coproporphyrin transport.	Coproporphyrins	19-33	solute carrier organic anion transporter family member 2B1	Homo sapiens	72-79
26383540-11	2016	The specificity of coproporphyrin transport was also investigated where OATP2B1 demonstrated meaningful transport of coproporphyrin III (Km = 0.31 microM), while OCT1, OCT2, OAT1, OAT3 and NTCP were negative for coproporphyrin transport.	Coproporphyrins	117-131	solute carrier organic anion transporter family member 2B1	Homo sapiens	72-79
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	22-37	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-45
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	22-37	solute carrier organic anion transporter family member 1A2	Homo sapiens	99-103
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	155-170	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-45
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	155-170	solute carrier organic anion transporter family member 1A2	Homo sapiens	99-103
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	155-170	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-45
26383540-13	2016	The identification of coproporphyrins as OATP substrates in vitro more clearly defines the role of OATPs in the hepatic disposition and renal excretion of coproporphyrins I and III and provides compelling evidence for future in vivo exploration of coproporphyrins as biomarkers of OATP activity.	Coproporphyrins	155-170	solute carrier organic anion transporter family member 1A2	Homo sapiens	99-103
21103937-6	2011	He was homoallelic for the CPOX missense mutation, c.980A>G (p.H327R), and had massively increased urinary uroporphyrins I and III (9,250 and 2,910 muM, respectively) and coproporphyrins I and III (895 and 19,400 muM, respectively).	Coproporphyrins	174-189	coproporphyrinogen oxidase	Homo sapiens	27-31
20610401-5	2010	Besides heme, FLVCR could export other cyclic planar porphyrins, such as protoporphyrin IX and coproporphyrin.	Coproporphyrins	95-109	FLVCR heme transporter 1	Homo sapiens	14-19
19656454-0	2009	Role of Multidrug-Resistance Protein 2 in coproporphyrin transport: results from experimental studies in bile fistula rat models.	Coproporphyrins	42-56	ATP binding cassette subfamily B member 4	Rattus norvegicus	8-38
12726999-6	2003	Binding affinities (K(D) values) of the GST isoforms are between 0.3 and 0.8 microM for coproporphyrin and about 2 microM for mesoporphyrin.Zm GST III-III prevents the nonenzymatic autoxidation of protoporphyrinogen to the phytotoxic PPIX.	Coproporphyrins	88-102	glutathione S-transferase 3	Zea mays	143-150
12509968-4	2003	Protoporphyrin and coproporphyrin were identified as the fluorescent substance in the SCC samples, and the elution patterns on HPLC revealed some porphyrin compounds as specific to oral cancer.	Coproporphyrins	19-33	serpin family B member 3	Homo sapiens	86-89
9462661-13	1998	A small increase in hepatic coproporphyrin in nonporphyric patients could reflect hepatic injury/iron/alcohol-induced oxidative stress oxidizing the accumulated heme precursors rather than a direct effect on hepatic URO-D enzyme.	Coproporphyrins	28-42	uroporphyrinogen decarboxylase	Homo sapiens	216-221
9164531-2	1997	However, after completion of interferon-beta administration for 6 weeks, urinary excretion of uroporphyrin and coproporphyrin, serum enzymes and ferritin were significantly decreased correspondent with diminished hepatitis C virus RNA titer.	Coproporphyrins	111-125	interferon beta 1	Homo sapiens	29-44
8778203-11	1996	In mice homozygous for a disruption of the mdr2 P-glycoprotein gene, resulting in complete absence of phospholipids in bile and strongly reduced cholesterol output, secretion of protoporphyrin was reduced by 90%, whereas that of coproporphyrin I and III was affected to a much lesser extent.	Coproporphyrins	229-243	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	43-47
9156565-6	1997	Although urinary porphyrin excretions of relatives were in the physiological range, the proportion of coproporphyrin isomer I showed a relative increase, which can serve as a biochemical indicator for heterozygous uroporphyrinogen III synthase gene carriers.	Coproporphyrins	102-116	uroporphyrinogen III synthase	Homo sapiens	214-243
8778203-11	1996	In mice homozygous for a disruption of the mdr2 P-glycoprotein gene, resulting in complete absence of phospholipids in bile and strongly reduced cholesterol output, secretion of protoporphyrin was reduced by 90%, whereas that of coproporphyrin I and III was affected to a much lesser extent.	Coproporphyrins	229-243	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	48-62
7682572-3	1993	Decreased protoporphyrinogen oxidase activity results in accumulation of protoporphyrin (ogen) IX and coproporphyrin (ogen) III.	Coproporphyrins	102-116	protoporphyrinogen oxidase	Homo sapiens	10-36
8519522-11	1995	The decrease in renal URO-D activity may help to explain the inversion in the coproporphyrin/uroporphyrin ratio previously reported in humans chronically exposed to As; however, there were differences between the urinary porphyrin profiles found in both species.	Coproporphyrins	78-92	uroporphyrinogen decarboxylase	Homo sapiens	22-27
1282871-4	1992	The activities of delta-aminolevulinic acid dehydratase (ALA-D) in the whole blood, free erythrocyte propoporhyrins, urine delta-aminolevulinic acid, and coproporphyrins (CP-U) were determined.	Coproporphyrins	154-169	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	57-62
34117512-3	2021	Here, we prospectively examined the effects of OATP1B1 function on the area under the plasma total or unbound concentration-time curve (tAUC or uAUC) of SN-38 by assessing OATP1B1 521T>C and the plasma levels of endogenous OATP1B1 substrates, coproporphyrin (CP)-I and III, in cancer patients treated with irinotecan.	Coproporphyrins	243-257	solute carrier organic anion transporter family member 1B1	Homo sapiens	47-54