PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2879704-1 1986 The present investigation revealed the effect of the organochlorine insecticide dieldrin at the dose level 0.25 LD50 at different time intervals on the concentration of 11 rat brain amino acids, on the activities of glutamic oxyacetic transaminase (GOT), glutamic pyruvic transaminase (GpT) and cholinesterase. Dieldrin 80-88 glutamic--pyruvic transaminase Rattus norvegicus 286-289 2444176-4 1987 Fall in the activity potential of AChE may account for the interference of dieldrin or its metabolites with the acetylcholine (ACh)--AChE system and deserve consideration in contributing to the neurotoxicity. Dieldrin 75-83 acetylcholinesterase Mus musculus 34-38 2444176-4 1987 Fall in the activity potential of AChE may account for the interference of dieldrin or its metabolites with the acetylcholine (ACh)--AChE system and deserve consideration in contributing to the neurotoxicity. Dieldrin 75-83 acetylcholinesterase Mus musculus 133-137 3809724-1 1986 The pretreatment of calves with a single dose of 10 mg kg-1 dieldrin or 21 daily doses of 10 mg kg-1 phenobarbitone increased the toxicity of diazinon as reflected by the development of more severe clinical signs and greater depression in whole blood cholinesterase activity in the pretreated calves. Dieldrin 60-68 butyrylcholinesterase Bos taurus 251-265 3756618-7 1986 Hepatic FDP activity was elevated in the 5-day-old rat at 1 h (17%) and was decreased (10%) in the 10-day-old rat at 3 h. Hepatic PEPCK activity was increased in adult animals by 30% 1 h after dieldrin. Dieldrin 193-201 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 130-135 3756618-10 1986 Thus only the activity of hepatic PEPCK is consistently elevated by dieldrin exposure. Dieldrin 68-76 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 34-39 3756618-11 1986 However, this enhanced PEPCK activity is associated with dieldrin-induced hyperglycemia only in the adult rat. Dieldrin 57-65 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 23-28 2974087-0 1988 Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain. Dieldrin 21-29 calmodulin 1 Rattus norvegicus 43-53 2974087-2 1988 Dieldrin inhibited both CaM-dependent and -independent Ca2+-ATPase activity and the enzyme activity decreased to 36% (CaM-dependent)--and 18% (basal) respectively after 60 d of intoxication. Dieldrin 0-8 calmodulin 1 Rattus norvegicus 24-27 2974087-2 1988 Dieldrin inhibited both CaM-dependent and -independent Ca2+-ATPase activity and the enzyme activity decreased to 36% (CaM-dependent)--and 18% (basal) respectively after 60 d of intoxication. Dieldrin 0-8 calmodulin 1 Rattus norvegicus 118-121 2974087-3 1988 Reduction in brain CaM levels and a subsequent inhibition of Ca2+-ATPase activity suggests that chronic intoxication of dieldrin at very low doses alters calmodulin and its regulation of Ca2+-ATPase activity. Dieldrin 120-128 calmodulin 1 Rattus norvegicus 19-22 2974087-3 1988 Reduction in brain CaM levels and a subsequent inhibition of Ca2+-ATPase activity suggests that chronic intoxication of dieldrin at very low doses alters calmodulin and its regulation of Ca2+-ATPase activity. Dieldrin 120-128 calmodulin 1 Rattus norvegicus 154-164 3606656-3 1987 A novel aldrin metabolite, endo-dieldrin, was formed by cytochrome P-450UT-F in a 6-fold excess over dieldrin, which is the exo-isomer. Dieldrin 32-40 cytochrome P450, family 2, subfamily a, polypeptide 1 Rattus norvegicus 56-76 3493551-2 1987 injection of dieldrin on the primary antibody response to thymodependent (sheep red blood cells, SRBC) and T-cell-independent (lipopolysaccharide, LPS) antigens were investigated in inbred C57Bl/6 mice. Dieldrin 13-21 caveolae associated 3 Mus musculus 97-101 3493551-3 1987 Time-course studies showed significant suppression of the anti-SRBC IgM and anti-LPS IgM response at 7-24 days and at 4-14 days, respectively, after exposure to 0.6 LD50 of dieldrin. Dieldrin 173-181 caveolae associated 3 Mus musculus 63-67 3493551-4 1987 The anti-SRBC IgG response was also suppressed by dieldrin exposure, however, maximal suppressory effect was found at 48 days after the pesticide exposure. Dieldrin 50-58 caveolae associated 3 Mus musculus 9-13 2879704-1 1986 The present investigation revealed the effect of the organochlorine insecticide dieldrin at the dose level 0.25 LD50 at different time intervals on the concentration of 11 rat brain amino acids, on the activities of glutamic oxyacetic transaminase (GOT), glutamic pyruvic transaminase (GpT) and cholinesterase. Dieldrin 80-88 butyrylcholinesterase Rattus norvegicus 295-309 7149987-2 1982 Dieldrin treated rats showed high levels of liver ascorbic acid and increased activities of inorganic pyrophosphatase in brain and glucose-6-phosphatase in liver. Dieldrin 0-8 inorganic pyrophosphatase 1 Rattus norvegicus 92-117 4049384-4 1985 It also prevented the increases that dieldrin causes in hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity. Dieldrin 37-45 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 64-97 4049384-4 1985 It also prevented the increases that dieldrin causes in hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity. Dieldrin 37-45 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 99-104 4049384-12 1985 L-alpha-Methyldopa also reduced (49%) the dieldrin-effected increase in hepatic PEPCK activity. Dieldrin 42-50 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 80-85 3920978-0 1985 Cholinesterase activities in developing amphibian embryos following exposure to the insecticides dieldrin and malathion. Dieldrin 97-105 butyrylcholinesterase Homo sapiens 0-14 7149987-2 1982 Dieldrin treated rats showed high levels of liver ascorbic acid and increased activities of inorganic pyrophosphatase in brain and glucose-6-phosphatase in liver. Dieldrin 0-8 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 131-152 288335-3 1979 mAHH and nAHH were slightly induced with dieldrin (130% and 120%), but the binding remained unchanged. Dieldrin 41-49 aryl-hydrocarbon receptor Mus musculus 0-4 6124057-1 1982 Dieldrin, an organochlorine insecticide, when administered orally to male albino rats at a dose of 5 mg/kg body weight/day for 15 days inhibits the enzyme Mg2+ -ATPase and stimulates the activity of 5"-nucleotidase and NADH-dehydrogenase in liver plasma membrane. Dieldrin 0-8 5' nucleotidase, ecto Rattus norvegicus 199-214 7265927-1 1981 Reduced quantitative recovery of dieldrin (1, 2, 3, 4, 10, -10-hexachloro-6, 7-epoxy-1, 4, 4a, 5, 6, 7, 8, 8a-octahydro-1, 4-endo, exo-5, 8-dimethanoaphthalene) while using concentrated sulfuric acid for the cleanup of the extracted samples, has been investigated by gas-liquid chromatography and infrared (IR) spectroscopy. Dieldrin 33-41 exonuclease 5 Homo sapiens 131-136 7389007-1 1980 The induction of rat liver microsomal monooxygenase by pretreatment of rats with dieldrin affords a 10-fold protection against the acute toxic effects of the organophosphorus insecticide, chlorfenvinphos. Dieldrin 81-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 27-51 6780342-3 1980 Cytochrome P-450, purified from hepatic microsomes of phenobarbital-treated rats, exhibited a high rate of dieldrin formation. Dieldrin 107-115 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 728164-0 1978 Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers. Dieldrin 174-182 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 32-60 817422-0 1976 Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Dieldrin 97-105 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 15-39 1098224-0 1975 Interaction of endrin and dieldrin with hepatic microsomal cytochrome P-450 from the rat, mouse, and endrin-susceptible and resistant pine voles. Dieldrin 26-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 59-75 1215658-0 1975 The effect of dieldrin-contaminated feed on rat hepatic microsomal epoxide hydrase and aryl hydrocarbon hydroxylase. Dieldrin 14-22 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 87-115 34051100-5 2021 Dieldrin exterted a similar effect in inhibiting IFIT2 and MX1 gene expression in human human SH-SY5Y neuronal cells induced by an RNA viral mimic, polyinosinic:polycytidylic acid (poly I:C) and IFIT2/3 gene expression in human pulmonary epithelial cells exposed to human influenza H1N1 virus. Dieldrin 0-8 interferon induced protein with tetratricopeptide repeats 2 Homo sapiens 49-54 13972395-0 1962 Mass poisoning on a ship caused by the insecticide dieldrin. Dieldrin 51-59 inositol polyphosphate-5-phosphatase D Homo sapiens 20-24 13281931-0 1955 An experiment in mosquito control using dieldrin dispersed as a dry fog. Dieldrin 40-48 zinc finger protein, FOG family member 1 Homo sapiens 68-71 4854687-0 1974 The comparative metabolism and excretion of HCE, a biodegradable analogue of dieldrin, by vertebrate species. Dieldrin 77-85 RNA guanylyltransferase and 5'-phosphatase Homo sapiens 44-47 34051100-5 2021 Dieldrin exterted a similar effect in inhibiting IFIT2 and MX1 gene expression in human human SH-SY5Y neuronal cells induced by an RNA viral mimic, polyinosinic:polycytidylic acid (poly I:C) and IFIT2/3 gene expression in human pulmonary epithelial cells exposed to human influenza H1N1 virus. Dieldrin 0-8 MX dynamin like GTPase 1 Homo sapiens 59-62 34051100-5 2021 Dieldrin exterted a similar effect in inhibiting IFIT2 and MX1 gene expression in human human SH-SY5Y neuronal cells induced by an RNA viral mimic, polyinosinic:polycytidylic acid (poly I:C) and IFIT2/3 gene expression in human pulmonary epithelial cells exposed to human influenza H1N1 virus. Dieldrin 0-8 interferon induced protein with tetratricopeptide repeats 2 Homo sapiens 195-202 32435917-0 2020 Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. Dieldrin 48-56 nuclear receptor subfamily 1, group I, member 3 Mus musculus 0-32 33440917-6 2021 Insulin resistance showed to be significantly positive correlation with beta-HCH and dieldrin. Dieldrin 85-93 insulin Homo sapiens 0-7 32980057-2 2020 Since the substitution of a single amino acid (Ala to Ser/Gly at position 302) of the Drosophila melanogaster Rdl gene was first identified to confer high level resistance to dieldrin, mutations at the equivalent positions have been reported to confer resistance to dieldrin and/or fipronil in a wide range of different insects. Dieldrin 175-183 Resistant to dieldrin Drosophila melanogaster 110-113 32435917-0 2020 Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. Dieldrin 48-56 nuclear receptor subfamily 1, group I, member 3 Mus musculus 34-37 32435917-7 2020 Analysis of the expression of the nuclear receptor responsive genes revealed that dieldrin induced a significant increase in the expression of genes specific to CAR activation (Cyp2b10, up to 400- to 2700-fold) and PXR activation (Cyp3a11, up to 5- to 11-fold) over untreated controls. Dieldrin 82-90 nuclear receptor subfamily 1, group I, member 3 Mus musculus 161-164 32435917-7 2020 Analysis of the expression of the nuclear receptor responsive genes revealed that dieldrin induced a significant increase in the expression of genes specific to CAR activation (Cyp2b10, up to 400- to 2700-fold) and PXR activation (Cyp3a11, up to 5- to 11-fold) over untreated controls. Dieldrin 82-90 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 177-184 32435917-7 2020 Analysis of the expression of the nuclear receptor responsive genes revealed that dieldrin induced a significant increase in the expression of genes specific to CAR activation (Cyp2b10, up to 400- to 2700-fold) and PXR activation (Cyp3a11, up to 5- to 11-fold) over untreated controls. Dieldrin 82-90 nuclear receptor subfamily 1, group I, member 2 Mus musculus 215-218 32435917-7 2020 Analysis of the expression of the nuclear receptor responsive genes revealed that dieldrin induced a significant increase in the expression of genes specific to CAR activation (Cyp2b10, up to 400- to 2700-fold) and PXR activation (Cyp3a11, up to 5- to 11-fold) over untreated controls. Dieldrin 82-90 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 231-238 32435917-9 2020 PPARalpha activation was not seen in the liver following dieldrin treatment. Dieldrin 57-65 peroxisome proliferator activated receptor alpha Mus musculus 0-9 32435917-11 2020 In a subsequent study using CAR, PXR, and CAR/PXR knockout mice, we confirmed that the dieldrin-induced liver effects in mouse were only mediated by the activation of CAR receptor. Dieldrin 87-95 nuclear receptor subfamily 1, group I, member 3 Mus musculus 28-31 32435917-11 2020 In a subsequent study using CAR, PXR, and CAR/PXR knockout mice, we confirmed that the dieldrin-induced liver effects in mouse were only mediated by the activation of CAR receptor. Dieldrin 87-95 nuclear receptor subfamily 1, group I, member 2 Mus musculus 33-36 32435917-11 2020 In a subsequent study using CAR, PXR, and CAR/PXR knockout mice, we confirmed that the dieldrin-induced liver effects in mouse were only mediated by the activation of CAR receptor. Dieldrin 87-95 nuclear receptor subfamily 1, group I, member 3 Mus musculus 42-45 32435917-11 2020 In a subsequent study using CAR, PXR, and CAR/PXR knockout mice, we confirmed that the dieldrin-induced liver effects in mouse were only mediated by the activation of CAR receptor. Dieldrin 87-95 nuclear receptor subfamily 1, group I, member 2 Mus musculus 46-49 32435917-12 2020 Based on these findings, we propose that dieldrin induced liver tumors in mice through a nuclear receptor CAR-mediated mode of action. Dieldrin 41-49 nuclear receptor subfamily 1, group I, member 3 Mus musculus 106-109 32435917-13 2020 The previously observed oxidative stress/damage may be an associated or modifying factor in the process of dieldrin-induced liver tumor formation subsequent to the CAR activation. Dieldrin 107-115 nuclear receptor subfamily 1, group I, member 3 Mus musculus 164-167 32143025-13 2020 In rats, we observed highest enrichment (p < 0.001) for cadmium (PRR = 8.7), carbon tetrachloride (PRR = 8.3), and dieldrin (PRR = 5.3). Dieldrin 115-123 proline rich 5 Rattus norvegicus 125-132 32421776-6 2020 Additionally, disruption of regulatory components of the mTOR pathway which integrates cellular responses to both intracellular and extracellular signals and is a central regulator for cell metabolism, growth, proliferation and survival, led to increased sensitivity to dieldrin-induced cellular toxicity. Dieldrin 270-278 mechanistic target of rapamycin kinase Homo sapiens 57-61 32083470-0 2020 Biotransformation Mechanism of Pesticides by Cytochrome P450: A DFT Study on Dieldrin. Dieldrin 77-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-60 32422283-0 2020 Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits. Dieldrin 55-63 synuclein, alpha Mus musculus 101-116 32422283-4 2020 We therefore studied dieldrin-induced neurotoxicity in the alpha-synuclein (alpha-syn)-preformed fibril (PFF) model, which better reflects the alpha-syn pathology and toxicity observed in PD pathogenesis. Dieldrin 21-29 synuclein, alpha Mus musculus 59-74 32422283-4 2020 We therefore studied dieldrin-induced neurotoxicity in the alpha-synuclein (alpha-syn)-preformed fibril (PFF) model, which better reflects the alpha-syn pathology and toxicity observed in PD pathogenesis. Dieldrin 21-29 synuclein, alpha Mus musculus 59-68 32422283-5 2020 Specifically, we used a "two-hit" model to determine whether developmental dieldrin exposure increases susceptibility to alpha-syn PFF-induced synucleinopathy. Dieldrin 75-83 synuclein, alpha Mus musculus 121-130 31812410-4 2020 Results showed that all chemical"s HC5 decreased with time, but their decreasing rates of HC5 (k) are significantly different: for some chemicals the k are lower than 0.001 (e.g., methoxychlor and dieldrin), while for some chemicals the k are higher than 0.05 (e.g., PCP and aldicarb). Dieldrin 197-205 CYCS pseudogene 1 Homo sapiens 35-38 31812410-4 2020 Results showed that all chemical"s HC5 decreased with time, but their decreasing rates of HC5 (k) are significantly different: for some chemicals the k are lower than 0.001 (e.g., methoxychlor and dieldrin), while for some chemicals the k are higher than 0.05 (e.g., PCP and aldicarb). Dieldrin 197-205 CYCS pseudogene 1 Homo sapiens 90-93 30820175-9 2019 [3H]EBOB binding data showed that gamma-BHC, its analogs, dieldrin, and other cyclodiene insecticides interact with the same site on GABA receptor as picrotoxinin. Dieldrin 58-66 GABA type A receptor-associated protein Homo sapiens 133-146 31081291-3 2019 Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50 ) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively. Dieldrin 11-19 gamma-aminobutyric acid receptor subunit beta Apis mellifera 134-137 31081291-3 2019 Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50 ) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively. Dieldrin 11-19 gamma-aminobutyric acid receptor subunit beta Apis mellifera 139-144 28385489-7 2017 Strong and dose- dependent inhibition of neurite outgrowth was induced by azamethiphos and chlorpyrifos, and dieldrin and heptachlor, which was correlated with up-regulation of gap-43. Dieldrin 109-117 growth associated protein 43 Rattus norvegicus 177-183 30240590-5 2018 Furthermore, treatment with dieldrin and lindane upregulated the cellular expression of Nox1 but not p67phox protein. Dieldrin 28-36 NADPH oxidase 1 Rattus norvegicus 88-92 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Dieldrin 15-23 NADPH oxidase 1 Rattus norvegicus 86-90 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Dieldrin 15-23 NADPH oxidase 1 Rattus norvegicus 158-162 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Dieldrin 174-182 NADPH oxidase 1 Rattus norvegicus 86-90 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Dieldrin 174-182 NADPH oxidase 1 Rattus norvegicus 158-162 29109678-3 2017 To gain insight into processes that might regulate sleep and buffer neuronal circuits during sleep loss, we manipulated three genes, fat facet (faf), highwire (hiw) and the GABA receptor Resistance to dieldrin (Rdl), that were differentially modulated in a Drosophila model of insomnia. Dieldrin 201-209 Resistant to dieldrin Drosophila melanogaster 211-214 30559597-1 2018 Recently, Taylor-Wells et al published evidence that the gamma-aminobutyric acid (GABA) receptor, resistance to dieldrin (RDL), from mosquitoes undergoes RNA A-to-I editing to generate an extraordinarily large range of isoforms. Dieldrin 112-120 GABA type A receptor-associated protein Homo sapiens 57-96 27744694-5 2016 MAb DrA-04 showed high reactivity toward dieldrin with ca. Dieldrin 41-49 olfactory receptor C family, g2 Danio rerio 4-10 28385952-0 2017 Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). Dieldrin 0-8 mechanistic target of rapamycin kinase Danio rerio 18-22 28385952-7 2017 To verify these findings, proteins in these pathways were examined with immunoblotting, and our results demonstrate that dieldrin constitutively activates Akt/mTOR signaling and downregulates lysosomal genes, participating in autophagy. Dieldrin 121-129 mechanistic target of rapamycin kinase Danio rerio 159-163 28163252-0 2017 The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Dieldrin 21-29 solute carrier family 6 member 3 Danio rerio 79-99 27744694-7 2016 MAb DrC-02 displayed a similar reactivity toward dieldrin and heptachlors. Dieldrin 49-57 olfactory receptor C family, x2 Danio rerio 4-10 27744694-10 2016 Concentrations of dieldrin and heptachlors in standard mixtures, calculated on the basis of an immunoassay with MAbs DrA-04 and DrC-02, were 88.1-125 and 96.2-115% of the theoretical values, respectively, revealing excellent sensitivity and specificity of this assay. Dieldrin 18-26 olfactory receptor C family, g2 Danio rerio 117-123 27744694-10 2016 Concentrations of dieldrin and heptachlors in standard mixtures, calculated on the basis of an immunoassay with MAbs DrA-04 and DrC-02, were 88.1-125 and 96.2-115% of the theoretical values, respectively, revealing excellent sensitivity and specificity of this assay. Dieldrin 18-26 olfactory receptor C family, x2 Danio rerio 128-134 26361738-2 2016 It has been suggested that broflanilide is metabolized to desmethyl-broflanilide and that it acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist. Dieldrin 131-139 Resistant to dieldrin Drosophila melanogaster 141-144 27513201-5 2016 Pretreatment for 1 h with quercetin before dieldrin application could significantly suppress dieldrin-induced apoptotic characteristics, including nuclear condensation, DNA fragmentation, and caspase-3/7 activation. Dieldrin 93-101 caspase 3 Mus musculus 192-201 27513201-6 2016 Results showed that dieldrin-induced markers of endoplasmic reticulum (ER) stress response such as chaperone GRP78, heme oxygenase-1, and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Dieldrin 20-28 heat shock protein 5 Mus musculus 109-114 27513201-6 2016 Results showed that dieldrin-induced markers of endoplasmic reticulum (ER) stress response such as chaperone GRP78, heme oxygenase-1, and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Dieldrin 20-28 heme oxygenase 1 Mus musculus 116-132 27513201-7 2016 In addition, dieldrin reduced antiapoptotic Bcl-2 expression, but significantly elevated a proapoptotic transcription factor CHOP. Dieldrin 13-21 B cell leukemia/lymphoma 2 Mus musculus 44-49 27513201-7 2016 In addition, dieldrin reduced antiapoptotic Bcl-2 expression, but significantly elevated a proapoptotic transcription factor CHOP. Dieldrin 13-21 DNA-damage inducible transcript 3 Mus musculus 125-129 27513201-8 2016 Furthermore, RNA interference to CHOP almost completely repressed dieldrin-induced apoptotic cell death. Dieldrin 66-74 DNA-damage inducible transcript 3 Mus musculus 33-37 26361738-2 2016 It has been suggested that broflanilide is metabolized to desmethyl-broflanilide and that it acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist. Dieldrin 131-139 Resistant to dieldrin Drosophila melanogaster 146-185 24584466-10 2014 It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD, the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD. Dieldrin 141-149 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 81-87 25771128-7 2015 Moreover, aldrin and dieldrin stimulated secretion of E2 and T from the granulosa cells, while only dieldrin increased (P<0.05) the secretion of P4 from luteal cells. Dieldrin 21-29 dihydrolipoamide branched chain transacylase E2 Bos taurus 54-62 25633958-7 2015 Human THP-1 monocytes treated with either trans-nonachlor or dieldrin (0.1-10 muM in the culture medium) exhibited elevated levels of intracellular ROS, as evidenced by complementary methods, including flow cytometry analysis using the probe DCFH-DA and hydroethidine-based fluorometric and UPLC-MS assays. Dieldrin 61-69 GLI family zinc finger 2 Homo sapiens 6-11 25633958-12 2015 Dieldrin and trans-nonachlor treatments of monocytes also resulted in marked increases in arachidonic acid (AA) and eicosanoid production, which could be abrogated by the phospholipase A2 (PLA2) inhibitor arachidonoyltrifluoromethyl ketone (ATK) but not by calcium-independent PLA2 inhibitor bromoenol lactone. Dieldrin 0-8 phospholipase A2 group IB Homo sapiens 171-187 25633958-12 2015 Dieldrin and trans-nonachlor treatments of monocytes also resulted in marked increases in arachidonic acid (AA) and eicosanoid production, which could be abrogated by the phospholipase A2 (PLA2) inhibitor arachidonoyltrifluoromethyl ketone (ATK) but not by calcium-independent PLA2 inhibitor bromoenol lactone. Dieldrin 0-8 phospholipase A2 group IB Homo sapiens 189-193 25633958-12 2015 Dieldrin and trans-nonachlor treatments of monocytes also resulted in marked increases in arachidonic acid (AA) and eicosanoid production, which could be abrogated by the phospholipase A2 (PLA2) inhibitor arachidonoyltrifluoromethyl ketone (ATK) but not by calcium-independent PLA2 inhibitor bromoenol lactone. Dieldrin 0-8 phospholipase A2 group IB Homo sapiens 277-281 24584466-10 2014 It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD, the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD. Dieldrin 141-149 glutathione S-transferase pi 1 Homo sapiens 94-99 24615737-0 2014 The effect of in vitro dieldrin exposure on the rat paraoxonase 1 (pon1) promoter. Dieldrin 23-31 paraoxonase 1 Rattus norvegicus 52-65 24615737-0 2014 The effect of in vitro dieldrin exposure on the rat paraoxonase 1 (pon1) promoter. Dieldrin 23-31 paraoxonase 1 Rattus norvegicus 67-71 24615737-3 2014 Putative binding sites for pregnane X receptor (PXR) exist in the paraoxonase promoter, and studies have indicated that dieldrin can activate PXR-regulated gene expression. Dieldrin 120-128 nuclear receptor subfamily 1, group I, member 2 Rattus norvegicus 27-46 24615737-3 2014 Putative binding sites for pregnane X receptor (PXR) exist in the paraoxonase promoter, and studies have indicated that dieldrin can activate PXR-regulated gene expression. Dieldrin 120-128 nuclear receptor subfamily 1, group I, member 2 Rattus norvegicus 48-51 24615737-3 2014 Putative binding sites for pregnane X receptor (PXR) exist in the paraoxonase promoter, and studies have indicated that dieldrin can activate PXR-regulated gene expression. Dieldrin 120-128 nuclear receptor subfamily 1, group I, member 2 Rattus norvegicus 142-145 24615737-5 2014 In vitro dieldrin concentrations from 10 to 100 microM significantly increased (p < 0.05) promoter activity in the presence of Pxr or Rxralpha alone and when Pxr plus Rxralpha were on the same vector, indicating that dieldrin can increase paraoxonase promoter activity in the presence of NRs. Dieldrin 9-17 nuclear receptor subfamily 1, group I, member 2 Rattus norvegicus 130-133 24615737-5 2014 In vitro dieldrin concentrations from 10 to 100 microM significantly increased (p < 0.05) promoter activity in the presence of Pxr or Rxralpha alone and when Pxr plus Rxralpha were on the same vector, indicating that dieldrin can increase paraoxonase promoter activity in the presence of NRs. Dieldrin 9-17 retinoid X receptor alpha Rattus norvegicus 137-145 24615737-5 2014 In vitro dieldrin concentrations from 10 to 100 microM significantly increased (p < 0.05) promoter activity in the presence of Pxr or Rxralpha alone and when Pxr plus Rxralpha were on the same vector, indicating that dieldrin can increase paraoxonase promoter activity in the presence of NRs. Dieldrin 9-17 nuclear receptor subfamily 1, group I, member 2 Rattus norvegicus 161-164 24615737-5 2014 In vitro dieldrin concentrations from 10 to 100 microM significantly increased (p < 0.05) promoter activity in the presence of Pxr or Rxralpha alone and when Pxr plus Rxralpha were on the same vector, indicating that dieldrin can increase paraoxonase promoter activity in the presence of NRs. Dieldrin 9-17 retinoid X receptor alpha Rattus norvegicus 170-178 25101650-9 2014 We found significantly high levels of beta-HCH, dieldrin and pp"-DDE in the CYP2D6*4 mt allelic variants, beta-HCH and pp"-DDE in the GSTP1*B allelic variants and dieldrin in the GSTP1*C allelic variants when comparing CYP2D6*4 non-mt, GSTP1 non-*B and GSTP1 non-*C allelic variants in patients of PD respectively. Dieldrin 48-56 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 76-82 24631345-6 2014 WAKE interacts with the GABAA receptor Resistant to Dieldrin (RDL), upregulating its levels and promoting its localization to the plasma membrane. Dieldrin 52-60 wide awake Drosophila melanogaster 0-4 24631345-6 2014 WAKE interacts with the GABAA receptor Resistant to Dieldrin (RDL), upregulating its levels and promoting its localization to the plasma membrane. Dieldrin 52-60 Resistant to dieldrin Drosophila melanogaster 62-65 23726008-8 2013 Dieldrin accelerated H2O2-induced cell death, which was estimated with the help of annexin V-FITC and propidium iodide. Dieldrin 0-8 annexin A5 Rattus norvegicus 83-92 25101650-10 2014 CONCLUSION: This study demonstrates that the CYP2D6*4 and GSTP1 genes may be considered as candidate genes for PD and they may also interact with beta- HCH, dieldrin and pp"-DDE to influence the risk for PD. Dieldrin 157-165 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 45-51 25101650-10 2014 CONCLUSION: This study demonstrates that the CYP2D6*4 and GSTP1 genes may be considered as candidate genes for PD and they may also interact with beta- HCH, dieldrin and pp"-DDE to influence the risk for PD. Dieldrin 157-165 glutathione S-transferase pi 1 Homo sapiens 58-63 20513056-1 2010 The Resistance to dieldrin (Rdl) gene encodes a subunit of the insect gamma-aminobutyric acid (GABA) receptor. Dieldrin 18-26 Resistant to dieldrin Drosophila melanogaster 28-31 22801081-6 2012 RESULTS: The postnatal exposure to dieldrin could reduce the level of growth associated protein (GAP43) of striatum in lactation in a dose-dependent manner. Dieldrin 35-43 growth associated protein 43 Mus musculus 97-102 22801081-10 2012 CONCLUSION: Early postnatal exposure to dieldrin could affect the expression level of GAP43 protein in striatum. Dieldrin 40-48 growth associated protein 43 Mus musculus 86-91 22679891-2 2012 In this study, using proteomic and immunoblotting analysis, we detected elevated levels of cystatin C in conditioned media (CM) from 1-methyl-4-phenylpyridinium and dieldrin-injured rat DA neuronal cells. Dieldrin 165-173 cystatin C Rattus norvegicus 91-101 22166974-7 2012 We also found that exposure to 60 nM dieldrin for 6 d in vitro caused the internalization of NR1 and NR2B but not NR2A. Dieldrin 37-45 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 93-96 22166974-7 2012 We also found that exposure to 60 nM dieldrin for 6 d in vitro caused the internalization of NR1 and NR2B but not NR2A. Dieldrin 37-45 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 101-105 22166974-8 2012 Treatment with either 1 nM E2 or 10 muM allopregnanolone prevented the dieldrin-induced reduction in membrane levels of the NR1/NR2B receptors. Dieldrin 71-79 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 124-127 22166974-8 2012 Treatment with either 1 nM E2 or 10 muM allopregnanolone prevented the dieldrin-induced reduction in membrane levels of the NR1/NR2B receptors. Dieldrin 71-79 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 128-132 22166974-9 2012 Furthermore, prolonged exposure to 200 nM dieldrin down-regulated the expression of NR2A; this was inhibited only by allopregnanolone. Dieldrin 42-50 glutamate ionotropic receptor NMDA type subunit 2A Homo sapiens 84-88 21278053-7 2011 Dieldrin and endosulfan increased Akt phosphorylation in CN, which was inhibited by the ERbeta antagonist 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol. Dieldrin 0-8 AKT serine/threonine kinase 1 Homo sapiens 34-37 21278053-7 2011 Dieldrin and endosulfan increased Akt phosphorylation in CN, which was inhibited by the ERbeta antagonist 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol. Dieldrin 0-8 estrogen receptor 2 Homo sapiens 88-94 21278053-8 2011 Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30. Dieldrin 51-59 AKT serine/threonine kinase 1 Homo sapiens 9-12 21278053-8 2011 Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30. Dieldrin 51-59 mitogen-activated protein kinase 3 Homo sapiens 17-23 21278053-8 2011 Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30. Dieldrin 51-59 estrogen receptor 1 Homo sapiens 106-113 21278053-8 2011 Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30. Dieldrin 51-59 estrogen receptor 2 Homo sapiens 115-121 21278053-8 2011 Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30. Dieldrin 51-59 G protein-coupled estrogen receptor 1 Homo sapiens 127-156 20584760-7 2010 Several proteins altered by dieldrin are known to be associated with human neurodegenerative diseases, including apolipoprotein E, microtubule-associated tau protein, enolase 1, stathmin 1a, myelin basic protein, and parvalbumin. Dieldrin 28-36 apolipoprotein E Homo sapiens 113-129 20584760-7 2010 Several proteins altered by dieldrin are known to be associated with human neurodegenerative diseases, including apolipoprotein E, microtubule-associated tau protein, enolase 1, stathmin 1a, myelin basic protein, and parvalbumin. Dieldrin 28-36 enolase 1 Homo sapiens 167-176 20584760-7 2010 Several proteins altered by dieldrin are known to be associated with human neurodegenerative diseases, including apolipoprotein E, microtubule-associated tau protein, enolase 1, stathmin 1a, myelin basic protein, and parvalbumin. Dieldrin 28-36 myelin basic protein Homo sapiens 191-211 20584760-7 2010 Several proteins altered by dieldrin are known to be associated with human neurodegenerative diseases, including apolipoprotein E, microtubule-associated tau protein, enolase 1, stathmin 1a, myelin basic protein, and parvalbumin. Dieldrin 28-36 parvalbumin Homo sapiens 217-228 20036686-6 2010 Mechanistically, dieldrin and lindane combination induced a rapid increase in the levels of intracellular reactive oxygen species, a decrease in mitochondrial membrane potential and activation of caspase 3/7. Dieldrin 17-25 caspase 3 Rattus norvegicus 196-205 19173004-0 2009 Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice. Dieldrin 42-50 erb-b2 receptor tyrosine kinase 2 Mus musculus 83-87 19906878-5 2010 Molecular analysis of the GABA-responding cells revealed that both subunits RDL and LCCH3 were expressed out of the three orthologs of Drosophila melanogaster GABA-receptor subunits encoded within the honeybee genome (RDL, resistant to dieldrin; GRD, GABA/glycine-like receptor of Drosophila; LCCH3, ligand-gated chloride channel homologue 3), opening the door to possible homo- and/or heteromeric associations. Dieldrin 236-244 Resistant to dieldrin Drosophila melanogaster 76-79 19906878-5 2010 Molecular analysis of the GABA-responding cells revealed that both subunits RDL and LCCH3 were expressed out of the three orthologs of Drosophila melanogaster GABA-receptor subunits encoded within the honeybee genome (RDL, resistant to dieldrin; GRD, GABA/glycine-like receptor of Drosophila; LCCH3, ligand-gated chloride channel homologue 3), opening the door to possible homo- and/or heteromeric associations. Dieldrin 236-244 Ligand-gated chloride channel homolog 3 Drosophila melanogaster 84-89 19906878-6 2010 The resulting receptors were activated by insect GABA-receptor agonists muscimol and CACA and blocked by antagonists fipronil, dieldrin, and picrotoxin, but not bicuculline, displaying a typical RDL-like pharmacology. Dieldrin 127-135 gamma-aminobutyric acid receptor subunit beta Apis mellifera 195-198 19812363-0 2010 Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation. Dieldrin 70-78 glutamate metabotropic receptor 5 Homo sapiens 122-155 19812363-7 2010 Exposure to dieldrin for 6 DIV induced N-methyl-D-aspartate receptor (NMDAR) internalization and reduced metabotropic glutamate receptor 5 (mGLUR5) levels. Dieldrin 12-20 glutamate metabotropic receptor 5 Homo sapiens 105-138 19812363-7 2010 Exposure to dieldrin for 6 DIV induced N-methyl-D-aspartate receptor (NMDAR) internalization and reduced metabotropic glutamate receptor 5 (mGLUR5) levels. Dieldrin 12-20 glutamate receptor, ionotropic, kainate 1 Mus musculus 140-146 19812363-8 2010 Double immunostaining for NMDAR and mGLUR5 showed that these receptors lose colocalization on the cell membrane in neurons treated with dieldrin. Dieldrin 136-144 glutamate receptor, ionotropic, kainate 1 Mus musculus 36-42 19422813-7 2009 Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p"-DDD plus p,p"-DDE plus o,p"-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Dieldrin 182-190 activin A receptor like type 1 Homo sapiens 273-279 19422813-7 2009 Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p"-DDD plus p,p"-DDE plus o,p"-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Dieldrin 182-190 activin A receptor like type 1 Homo sapiens 281-286 19422813-7 2009 Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p"-DDD plus p,p"-DDE plus o,p"-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Dieldrin 182-190 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 288-291 19422813-7 2009 Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p"-DDD plus p,p"-DDE plus o,p"-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Dieldrin 182-190 erb-b2 receptor tyrosine kinase 3 Homo sapiens 293-298 19422813-7 2009 Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p"-DDD plus p,p"-DDE plus o,p"-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Dieldrin 182-190 activin A receptor like type 1 Homo sapiens 304-309 19173004-0 2009 Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice. Dieldrin 42-50 erb-b2 receptor tyrosine kinase 2 Mus musculus 88-91 19173004-8 2009 Increased mRNA and protein expression of the neurotrophin BDNF and its receptor TrkB was increased in tumors from the offspring of dieldrin treated dams. Dieldrin 131-139 brain derived neurotrophic factor Homo sapiens 58-62 19173004-8 2009 Increased mRNA and protein expression of the neurotrophin BDNF and its receptor TrkB was increased in tumors from the offspring of dieldrin treated dams. Dieldrin 131-139 neurotrophic receptor tyrosine kinase 2 Homo sapiens 80-84 19173004-10 2009 Dieldrin exposure also altered the expression of BNDF and TrkB, novel modulators of cancer pathogenesis. Dieldrin 0-8 neurotrophic receptor tyrosine kinase 2 Homo sapiens 58-62 19133471-3 2008 The subunit gene encoded a 483-amino acid polypeptide that showed 84% sequence identity with DmRdl subunit (U02042) (Drosophila melanogaster resistant to dieldrin). Dieldrin 154-162 Resistant to dieldrin Drosophila melanogaster 93-98 18252963-11 2008 Our in vitro results show for the first time that genistein and xenoestrogens (BPA, OP, dieldrin, BBP, and DEHP at high concentrations) up-regulate VEGF expression in MELN cells by an ER-dependent mechanism. Dieldrin 88-96 vascular endothelial growth factor A Homo sapiens 148-152 18452993-5 2008 In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation. Dieldrin 63-71 heme oxygenase 1 Homo sapiens 80-96 18452993-6 2008 Both rotenone- and dieldrin-induced down-regulation of extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation was significantly blocked by pretreatment with L-theanine. Dieldrin 19-27 mitogen-activated protein kinase 1 Homo sapiens 55-95 18452993-6 2008 Both rotenone- and dieldrin-induced down-regulation of extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation was significantly blocked by pretreatment with L-theanine. Dieldrin 19-27 mitogen-activated protein kinase 3 Homo sapiens 97-103 18945348-0 2008 Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson"s disease. Dieldrin 25-33 caspase 3 Rattus norvegicus 56-65 18945348-0 2008 Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson"s disease. Dieldrin 25-33 protein kinase C, delta Rattus norvegicus 102-124 18945348-0 2008 Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson"s disease. Dieldrin 25-33 protein kinase C, delta Rattus norvegicus 126-134 18945348-5 2008 The cytosolic cytochrome c activated caspase-dependent apoptotic pathway and the increased caspase-3 activity was observed following a 3 hr dieldrin exposure in a dose-dependent manner. Dieldrin 140-148 caspase 3 Rattus norvegicus 91-100 18945348-7 2008 PKCdelta plays a critical role in executing the apoptotic process in dieldrin-treated dopaminergic neuronal cells because pretreatment with the PKCdelta inhibitor rottlerin, or transfection and over-expression of catalytically inactive PKCdelta(K)376(R), significantly attenuates dieldrin-induced DNA fragmentation and chromatin condensation. Dieldrin 69-77 protein kinase C, delta Rattus norvegicus 0-8 18945348-7 2008 PKCdelta plays a critical role in executing the apoptotic process in dieldrin-treated dopaminergic neuronal cells because pretreatment with the PKCdelta inhibitor rottlerin, or transfection and over-expression of catalytically inactive PKCdelta(K)376(R), significantly attenuates dieldrin-induced DNA fragmentation and chromatin condensation. Dieldrin 69-77 protein kinase C, delta Rattus norvegicus 144-152 18945348-7 2008 PKCdelta plays a critical role in executing the apoptotic process in dieldrin-treated dopaminergic neuronal cells because pretreatment with the PKCdelta inhibitor rottlerin, or transfection and over-expression of catalytically inactive PKCdelta(K)376(R), significantly attenuates dieldrin-induced DNA fragmentation and chromatin condensation. Dieldrin 69-77 protein kinase C, delta Rattus norvegicus 144-152 18945348-7 2008 PKCdelta plays a critical role in executing the apoptotic process in dieldrin-treated dopaminergic neuronal cells because pretreatment with the PKCdelta inhibitor rottlerin, or transfection and over-expression of catalytically inactive PKCdelta(K)376(R), significantly attenuates dieldrin-induced DNA fragmentation and chromatin condensation. Dieldrin 280-288 protein kinase C, delta Rattus norvegicus 0-8 18945348-8 2008 CONCLUSION: Together, we conclude that caspase-3-dependent proteolytic activation of PKCdelta is a critical event in dieldrin-induced apoptotic cell death in dopaminergic neuronal cells. Dieldrin 117-125 caspase 3 Rattus norvegicus 39-48 18945348-8 2008 CONCLUSION: Together, we conclude that caspase-3-dependent proteolytic activation of PKCdelta is a critical event in dieldrin-induced apoptotic cell death in dopaminergic neuronal cells. Dieldrin 117-125 protein kinase C, delta Rattus norvegicus 85-93 18040759-5 2008 Using phosphorylation site-specific antibodies, we demonstrated that lindane, dieldrin, and ChK all activated p44/42 ERK, but only ChK activated Akt kinase. Dieldrin 78-86 mitogen activated protein kinase 3 Rattus norvegicus 110-113 18040759-5 2008 Using phosphorylation site-specific antibodies, we demonstrated that lindane, dieldrin, and ChK all activated p44/42 ERK, but only ChK activated Akt kinase. Dieldrin 78-86 Eph receptor B1 Rattus norvegicus 117-120 17848404-7 2007 RESULTS: Exposure to dieldrin reduced LH-induced testosterone secretion (P < 0.05) and tissue protein concentrations of LH receptor and steroid acute regulatory protein (P < 0.05). Dieldrin 21-29 luteinizing hormone/choriogonadotropin receptor Homo sapiens 123-134 18242054-6 2008 Dieldrin increased resistance to anoikis and TrkB expression. Dieldrin 0-8 neurotrophic receptor tyrosine kinase 2 Homo sapiens 45-49 18242054-8 2008 Our results demonstrate that dieldrin increases resistance to anoikis and expression of TrkB and show for the first time TrkB protein expression in human breast cancer. Dieldrin 29-37 neurotrophic receptor tyrosine kinase 2 Homo sapiens 88-92 18242054-8 2008 Our results demonstrate that dieldrin increases resistance to anoikis and expression of TrkB and show for the first time TrkB protein expression in human breast cancer. Dieldrin 29-37 neurotrophic receptor tyrosine kinase 2 Homo sapiens 121-125 17848404-7 2007 RESULTS: Exposure to dieldrin reduced LH-induced testosterone secretion (P < 0.05) and tissue protein concentrations of LH receptor and steroid acute regulatory protein (P < 0.05). Dieldrin 21-29 steroidogenic acute regulatory protein Homo sapiens 139-171 15033812-3 2003 In the present study, we report that the proapoptotic function of PKCdelta can be regulated by overexpression of the mitochondrial anti-apoptotic protein Bcl2 in dieldrin-treated dopaminergic cells. Dieldrin 162-170 protein kinase C, delta Rattus norvegicus 66-74 16626760-6 2006 Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. Dieldrin 208-216 estrogen receptor 1 Homo sapiens 31-51 16809432-3 2006 At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. Dieldrin 149-157 solute carrier family 6 member 3 Homo sapiens 48-68 16809432-3 2006 At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. Dieldrin 149-157 solute carrier family 6 member 3 Homo sapiens 70-73 16809432-3 2006 At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. Dieldrin 149-157 solute carrier family 18 member A2 Homo sapiens 79-112 16809432-3 2006 At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. Dieldrin 149-157 solute carrier family 18 member A2 Homo sapiens 114-119 16809432-4 2006 We then administered MPTP (2 x 10 mg/kg s.c) at 12 wk of age and observed a greater reduction of striatal dopamine in dieldrin-exposed offspring, which was associated with a greater DAT:VMAT2 ratio. Dieldrin 118-126 solute carrier family 6 member 3 Homo sapiens 182-185 16809432-4 2006 We then administered MPTP (2 x 10 mg/kg s.c) at 12 wk of age and observed a greater reduction of striatal dopamine in dieldrin-exposed offspring, which was associated with a greater DAT:VMAT2 ratio. Dieldrin 118-126 solute carrier family 18 member A2 Homo sapiens 186-191 16809432-5 2006 Additionally, dieldrin exposure during development potentiated the increase in GFAP and alpha-synuclein levels induced by MPTP, indicating increased neurotoxicity. Dieldrin 14-22 glial fibrillary acidic protein Homo sapiens 79-83 16809432-5 2006 Additionally, dieldrin exposure during development potentiated the increase in GFAP and alpha-synuclein levels induced by MPTP, indicating increased neurotoxicity. Dieldrin 14-22 synuclein alpha Homo sapiens 88-103 15987830-0 2005 Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. Dieldrin 0-8 synuclein alpha Homo sapiens 53-68 15987830-5 2005 Dieldrin exposure dose-dependently (0-70 microM) decreased proteasomal activity, and 30 microM dieldrin inhibited activity by more than 60% in alpha-synuclein cells. Dieldrin 95-103 synuclein alpha Homo sapiens 143-158 15987830-6 2005 Confocal microscopic analysis of dieldrin-treated alpha-synuclein cells revealed that alpha-synuclein-positive protein aggregates colocalized with ubiquitin protein. Dieldrin 33-41 synuclein alpha Homo sapiens 50-65 15987830-6 2005 Confocal microscopic analysis of dieldrin-treated alpha-synuclein cells revealed that alpha-synuclein-positive protein aggregates colocalized with ubiquitin protein. Dieldrin 33-41 synuclein alpha Homo sapiens 86-101 15987830-8 2005 The dieldrin-induced proteasomal dysfunction in alpha-synuclein cells was also confirmed by significant accumulation of ubiquitin protein conjugates in the detergent-insoluble fraction. Dieldrin 4-12 synuclein alpha Homo sapiens 48-63 15987830-10 2005 Furthermore, measurement of caspase-3 and DNA fragmentation confirmed the enhanced sensitivity of alpha-synuclein cells to dieldrin-induced apoptosis. Dieldrin 123-131 caspase 3 Homo sapiens 28-37 15987830-10 2005 Furthermore, measurement of caspase-3 and DNA fragmentation confirmed the enhanced sensitivity of alpha-synuclein cells to dieldrin-induced apoptosis. Dieldrin 123-131 synuclein alpha Homo sapiens 98-113 15987830-11 2005 Together, our results suggest that increased expression of alpha-synuclein predisposes dopaminergic cells to proteasomal dysfunction, which can be further exacerbated by environmental exposure to certain neurotoxic compounds, such as dieldrin. Dieldrin 234-242 synuclein alpha Homo sapiens 59-74 16027231-2 2005 A GABA-gated chloride channel subunit from Drosophila melanogaster [Resistant to Dieldrin (RDL)] has been cloned, functionally expressed, and found to exhibit many aspects of the pharmacology of native, bicuculline-insensitive insect GABA receptors. Dieldrin 81-89 Resistant to dieldrin Drosophila melanogaster 91-94 16054614-7 2005 Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. Dieldrin 74-82 nuclear receptor subfamily 1 group I member 2 Homo sapiens 137-140 16054614-7 2005 Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. Dieldrin 74-82 nuclear receptor subfamily 1 group I member 2 Homo sapiens 149-152 16054614-7 2005 Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. Dieldrin 74-82 nuclear receptor subfamily 1 group I member 3 Homo sapiens 157-160 15888667-2 2005 The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. Dieldrin 66-74 mitogen-activated protein kinase 3 Homo sapiens 150-154 15770161-0 2005 Heme oxygenase-1 induction by dieldrin in dopaminergic cells. Dieldrin 30-38 heme oxygenase 1 Homo sapiens 0-16 15770161-1 2005 We investigated the transcriptional events and signaling pathways involved in the induction of heme oxygenase-1 (HO-1) by dieldrin, an environmental risk factor of Parkinson"s disease, in a dopaminergic neuronal cells (SN4741). Dieldrin 122-130 heme oxygenase 1 Homo sapiens 95-111 15770161-1 2005 We investigated the transcriptional events and signaling pathways involved in the induction of heme oxygenase-1 (HO-1) by dieldrin, an environmental risk factor of Parkinson"s disease, in a dopaminergic neuronal cells (SN4741). Dieldrin 122-130 heme oxygenase 1 Homo sapiens 113-117 15770161-2 2005 Dieldrin exposure caused dose-dependent and time-dependent induction of heme oxygenase activity and HO-1 protein expression. Dieldrin 0-8 heme oxygenase 1 Homo sapiens 100-104 15770161-3 2005 Deletional and mutational analyses showed that the 5" distal enhancers, E1 and E2, mediate dieldrin-induced HO-1 gene transcription, and the AP-1 DNA binding sites in the E2 enhancer are critical for E2-mediated HO-1 gene activation. Dieldrin 91-99 small nucleolar RNA, H/ACA box 73A Homo sapiens 72-81 15770161-3 2005 Deletional and mutational analyses showed that the 5" distal enhancers, E1 and E2, mediate dieldrin-induced HO-1 gene transcription, and the AP-1 DNA binding sites in the E2 enhancer are critical for E2-mediated HO-1 gene activation. Dieldrin 91-99 heme oxygenase 1 Homo sapiens 108-112 15770161-3 2005 Deletional and mutational analyses showed that the 5" distal enhancers, E1 and E2, mediate dieldrin-induced HO-1 gene transcription, and the AP-1 DNA binding sites in the E2 enhancer are critical for E2-mediated HO-1 gene activation. Dieldrin 91-99 heme oxygenase 1 Homo sapiens 212-216 15770161-4 2005 Furthermore, both the p38 and JNK mitogen-activated protein kinase pathways are utilized for HO-1 transcriptional activation by dieldrin. Dieldrin 128-136 mitogen-activated protein kinase 14 Homo sapiens 22-25 15770161-4 2005 Furthermore, both the p38 and JNK mitogen-activated protein kinase pathways are utilized for HO-1 transcriptional activation by dieldrin. Dieldrin 128-136 mitogen-activated protein kinase 8 Homo sapiens 30-33 15770161-4 2005 Furthermore, both the p38 and JNK mitogen-activated protein kinase pathways are utilized for HO-1 transcriptional activation by dieldrin. Dieldrin 128-136 heme oxygenase 1 Homo sapiens 93-97 15770161-5 2005 HO-1 inhibitor, ZnPP IX reduced the expression of HO-1 but enhanced the cytotoxicity induced by dieldrin. Dieldrin 96-104 heme oxygenase 1 Homo sapiens 0-4 15261991-7 2004 Co-exposure with E2 elicited a significant increased ERbeta mRNA level by prochloraz, fenarimol, endosulfan, dieldrin, and tolchlofos-methyl, whereas no significant effect of the carbamate pesticides on the ERbeta mRNA level was observed. Dieldrin 109-117 estrogen receptor 2 Homo sapiens 53-59 15183012-0 2004 Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Dieldrin 0-8 poly (ADP-ribose) polymerase 1 Rattus norvegicus 42-69 15183012-0 2004 Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Dieldrin 0-8 BCL2, apoptosis regulator Rattus norvegicus 165-170 15183012-1 2004 Previously, we demonstrated that the organochlorine pesticide dieldrin induces mitochondrial depolarization, caspase-3 activation and apoptosis in dopaminergic PC12 cells. Dieldrin 62-70 caspase 3 Rattus norvegicus 109-118 15183012-3 2004 In the present study, we have further characterized the protective effect of the major mitochondrial anti-apoptotic protein Bcl-2 against dieldrin-induced apoptotic events in dopaminergic cells. Dieldrin 138-146 BCL2, apoptosis regulator Rattus norvegicus 124-129 15183012-4 2004 Exposure to dieldrin (30-100 microM) produced significant cytotoxicity and caspase-3 activation within 3h in vector-transfected PC12 cells, whereas human Bcl-2-transfected PC12 cells were almost completely resistant to dieldrin-induced cytotoxicity and caspase-3 activation. Dieldrin 12-20 caspase 3 Rattus norvegicus 75-84 15183012-4 2004 Exposure to dieldrin (30-100 microM) produced significant cytotoxicity and caspase-3 activation within 3h in vector-transfected PC12 cells, whereas human Bcl-2-transfected PC12 cells were almost completely resistant to dieldrin-induced cytotoxicity and caspase-3 activation. Dieldrin 12-20 caspase 3 Rattus norvegicus 253-262 15183012-4 2004 Exposure to dieldrin (30-100 microM) produced significant cytotoxicity and caspase-3 activation within 3h in vector-transfected PC12 cells, whereas human Bcl-2-transfected PC12 cells were almost completely resistant to dieldrin-induced cytotoxicity and caspase-3 activation. Dieldrin 219-227 BCL2 apoptosis regulator Homo sapiens 154-159 15183012-5 2004 Also, dieldrin (30-300 microM) treatment induced proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), which was blocked by pretreatment with caspase-3 inhibitors Z-DEVD-FMK and Z-VAD-FMK. Dieldrin 6-14 poly (ADP-ribose) polymerase 1 Rattus norvegicus 73-100 15183012-5 2004 Also, dieldrin (30-300 microM) treatment induced proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), which was blocked by pretreatment with caspase-3 inhibitors Z-DEVD-FMK and Z-VAD-FMK. Dieldrin 6-14 poly (ADP-ribose) polymerase 1 Rattus norvegicus 102-106 15183012-5 2004 Also, dieldrin (30-300 microM) treatment induced proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), which was blocked by pretreatment with caspase-3 inhibitors Z-DEVD-FMK and Z-VAD-FMK. Dieldrin 6-14 caspase 3 Rattus norvegicus 148-157 15183012-6 2004 Additionally, dieldrin-induced chromatin condensation and DNA fragmentation were completely blocked in Bcl-2-overexpressed PC12 cells as compared to vector control cells. Dieldrin 14-22 BCL2, apoptosis regulator Rattus norvegicus 103-108 14636698-3 2003 We have used the AhR-CALUX assay to investigate the AhR-mediated activity of the persistent organochlorine insecticide dieldrin and twenty-two pesticides currently used in Denmark by employing the rat H4IIE and the human TV101L hepatoma cell lines. Dieldrin 119-127 aryl hydrocarbon receptor Rattus norvegicus 17-20 14636698-3 2003 We have used the AhR-CALUX assay to investigate the AhR-mediated activity of the persistent organochlorine insecticide dieldrin and twenty-two pesticides currently used in Denmark by employing the rat H4IIE and the human TV101L hepatoma cell lines. Dieldrin 119-127 aryl hydrocarbon receptor Rattus norvegicus 52-55 17517822-0 2007 Spatial distribution of CYP2B1/2 messenger RNA within the rat liver acinus following exposure to the inducers phenobarbital and dieldrin. Dieldrin 128-136 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 24-30 17517822-8 2007 Whole liver mRNA samples exhibited significant induction in CYP2B1/2 transcript levels: sixfold for PB and 2200-fold for dieldrin. Dieldrin 121-129 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 60-66 17517822-10 2007 Dieldrin caused marked increases in CYP2B1/2 mRNA levels in the direction of blood flow through the acinus: periportal, 300-fold; midzonal, 600-fold; and centrilobular, 1700-fold. Dieldrin 0-8 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 36-42 18958706-0 2006 Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine. Dieldrin 86-94 toll like receptor 3 Homo sapiens 37-41 18958706-0 2006 Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine. Dieldrin 86-94 interleukin 6 Homo sapiens 50-54 18958706-6 2006 Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected. Dieldrin 31-39 interleukin 6 Homo sapiens 145-149 18958706-6 2006 Subcutaneous administration of dieldrin (10-20 mg/kg, daily for 7 d) and atrazine (one dose on Day 7, 100-200 mg/kg) inhibited the production of IL-6 and IL-12 in the peritoneal cavity in a dose-dependent manner, but IL-10 was either increased or not affected. Dieldrin 31-39 interleukin 10 Homo sapiens 217-222 18958706-8 2006 However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1). Dieldrin 195-203 interleukin 6 Homo sapiens 207-211 18958706-11 2006 Dieldrin and atrazine administered orally (as opposed to subcutaneously as in the other experiments) also effectively suppressed IL-6 production. Dieldrin 0-8 interleukin 6 Homo sapiens 129-133 15589975-1 2005 Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE). Dieldrin 51-59 retinoic acid receptor alpha Homo sapiens 108-130 15589975-1 2005 Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE). Dieldrin 51-59 retinoic acid receptor alpha Homo sapiens 132-135 15033812-3 2003 In the present study, we report that the proapoptotic function of PKCdelta can be regulated by overexpression of the mitochondrial anti-apoptotic protein Bcl2 in dieldrin-treated dopaminergic cells. Dieldrin 162-170 BCL2, apoptosis regulator Rattus norvegicus 154-158 15033812-4 2003 Exposure to dieldrin (30 or 100 micro M) for 3 h produced a dose-dependent increase in caspase-3 activation and DNA fragmentation in vector-transfected PC12 cells. Dieldrin 12-20 caspase 3 Rattus norvegicus 87-96 15033812-5 2003 Overexpression of human Bcl-2 in PC12 cells completely suppressed dieldrin-induced caspase-3 activation and DNA fragmentation. Dieldrin 66-74 BCL2 apoptosis regulator Homo sapiens 24-29 15033812-5 2003 Overexpression of human Bcl-2 in PC12 cells completely suppressed dieldrin-induced caspase-3 activation and DNA fragmentation. Dieldrin 66-74 caspase 3 Rattus norvegicus 83-92 15033812-6 2003 Furthermore, dieldrin-induced proteolytic activation of PKCdelta was also remarkably reduced in Bcl-2-overexpressed cells. Dieldrin 13-21 protein kinase C, delta Rattus norvegicus 56-64 15033812-6 2003 Furthermore, dieldrin-induced proteolytic activation of PKCdelta was also remarkably reduced in Bcl-2-overexpressed cells. Dieldrin 13-21 BCL2, apoptosis regulator Rattus norvegicus 96-101 12167306-8 2002 If these compounds are classified according to the level of Vtg secreted, we observed the following decreasing order: 17beta-estradiol (E(2))>o,p"-DDT>dieldrin>aldrin>DDT. Dieldrin 157-165 LOC100136735 Oncorhynchus mykiss 60-63 12621067-1 2003 The involvement of the antioxidant enzymes catalase and glutathione peroxidase (both at 0.1 mg/ml) in defence against the genotoxicity of phosphamidon (80 microg/ml) and dieldrin (25 microM) was investigated in order to demonstrate that the two pesticides damage DNA through the generation of reactive oxygen species and therefore of oxidative stress. Dieldrin 170-178 catalase Mus musculus 43-51 12831855-0 2003 Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Dieldrin 0-8 caspase 3 Rattus norvegicus 40-49 12831855-0 2003 Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Dieldrin 0-8 protein kinase C, delta Rattus norvegicus 84-105 12831855-2 2003 Here, we demonstrate that the caspase-3-dependent proteolytic activation of protein kinase Cdelta (PKCdelta) mediates as well as regulates the dieldrin-induced apoptotic cascade in dopaminergic cells. Dieldrin 143-151 caspase 3 Rattus norvegicus 30-39 12831855-2 2003 Here, we demonstrate that the caspase-3-dependent proteolytic activation of protein kinase Cdelta (PKCdelta) mediates as well as regulates the dieldrin-induced apoptotic cascade in dopaminergic cells. Dieldrin 143-151 protein kinase C, delta Rattus norvegicus 76-97 12831855-2 2003 Here, we demonstrate that the caspase-3-dependent proteolytic activation of protein kinase Cdelta (PKCdelta) mediates as well as regulates the dieldrin-induced apoptotic cascade in dopaminergic cells. Dieldrin 143-151 protein kinase C, delta Rattus norvegicus 99-107 12831855-3 2003 Exposure of PC12 cells to dieldrin (100-300 microM) results in the rapid release of cytochrome C, followed by the activation of caspase-9 and caspase-3 in a time- and dose-dependent manner. Dieldrin 26-34 caspase 9 Rattus norvegicus 128-137 12831855-3 2003 Exposure of PC12 cells to dieldrin (100-300 microM) results in the rapid release of cytochrome C, followed by the activation of caspase-9 and caspase-3 in a time- and dose-dependent manner. Dieldrin 26-34 caspase 3 Rattus norvegicus 142-151 12831855-5 2003 Interestingly, dieldrin proteolytically cleaves native PKCdelta into a 41 kDa catalytic subunit and a 38 kDa regulatory subunit to activate the kinase. Dieldrin 15-23 protein kinase C, delta Rattus norvegicus 55-63 12831855-7 2003 Additionally, Z-VAD-FMK, Z-DEVD-FMK or the PKCdelta specific inhibitor rottlerin almost completely block dieldrin-induced DNA fragmentation. Dieldrin 105-113 protein kinase C, delta Rattus norvegicus 43-51 12831855-8 2003 Because dieldrin dramatically increases (40-80-fold) caspase-3 activity, we examined whether proteolytically activated PKCdelta amplifies caspase-3 via positive feedback activation. Dieldrin 8-16 caspase 3 Rattus norvegicus 53-62 12831855-9 2003 The PKCdelta inhibitor rottlerin (3-20 microM) dose-dependently attenuates dieldrin-induced caspase-3 activity, suggesting positive feedback activation of caspase-3 by PKCdelta. Dieldrin 75-83 protein kinase C, delta Rattus norvegicus 4-12 12831855-9 2003 The PKCdelta inhibitor rottlerin (3-20 microM) dose-dependently attenuates dieldrin-induced caspase-3 activity, suggesting positive feedback activation of caspase-3 by PKCdelta. Dieldrin 75-83 caspase 3 Rattus norvegicus 92-101 12831855-9 2003 The PKCdelta inhibitor rottlerin (3-20 microM) dose-dependently attenuates dieldrin-induced caspase-3 activity, suggesting positive feedback activation of caspase-3 by PKCdelta. Dieldrin 75-83 caspase 3 Rattus norvegicus 155-164 12831855-9 2003 The PKCdelta inhibitor rottlerin (3-20 microM) dose-dependently attenuates dieldrin-induced caspase-3 activity, suggesting positive feedback activation of caspase-3 by PKCdelta. Dieldrin 75-83 protein kinase C, delta Rattus norvegicus 168-176 12831855-11 2003 Finally, overexpression of the kinase-inactive PKCdelta(K376R) mutant in rat mesencephalic dopaminergic neuronal cells attenuates dieldrin-induced caspase-3 activity and DNA fragmentation, further confirming the pro-apoptotic function of PKCdelta in dopaminergic cells. Dieldrin 130-138 protein kinase C, delta Rattus norvegicus 47-55 12831855-11 2003 Finally, overexpression of the kinase-inactive PKCdelta(K376R) mutant in rat mesencephalic dopaminergic neuronal cells attenuates dieldrin-induced caspase-3 activity and DNA fragmentation, further confirming the pro-apoptotic function of PKCdelta in dopaminergic cells. Dieldrin 130-138 caspase 3 Rattus norvegicus 147-156 12831855-11 2003 Finally, overexpression of the kinase-inactive PKCdelta(K376R) mutant in rat mesencephalic dopaminergic neuronal cells attenuates dieldrin-induced caspase-3 activity and DNA fragmentation, further confirming the pro-apoptotic function of PKCdelta in dopaminergic cells. Dieldrin 130-138 protein kinase C, delta Rattus norvegicus 238-246 12831855-12 2003 Together, we conclude that caspase-3-dependent proteolytic activation of PKCdelta is a critical event in dieldrin-induced apoptotic cell death in dopaminergic cells. Dieldrin 105-113 caspase 3 Rattus norvegicus 27-36 12831855-12 2003 Together, we conclude that caspase-3-dependent proteolytic activation of PKCdelta is a critical event in dieldrin-induced apoptotic cell death in dopaminergic cells. Dieldrin 105-113 protein kinase C, delta Rattus norvegicus 73-81 11859874-10 2002 A non-significant increased risk of breast cancer was observed in the highest exposure level of dieldrin and polychlorinated biphenyls among women who developed a tumor with mutant p53 (odds ratio (OR) = 3.53, 95% confidence interval (CI) = 0.79-15.79 and OR = 3.00, 95% CI = 0.66-13.62). Dieldrin 96-104 tumor protein p53 Homo sapiens 181-184 11859874-11 2002 There was no clear difference in overall survival between breast cancer cases with "wild-type" and mutant p53, although a significant dose-response relationship appeared for dieldrin exposure in tumors with "wild-type" p53. Dieldrin 174-182 tumor protein p53 Homo sapiens 219-222 12049174-8 2002 CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, clotrimazole and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. Dieldrin 135-143 nuclear receptor subfamily 1, group I, member 3 Mus musculus 0-3 12049174-8 2002 CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, clotrimazole and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. Dieldrin 135-143 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 41-48 12049174-8 2002 CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, clotrimazole and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. Dieldrin 135-143 nuclear receptor subfamily 1, group I, member 2 Mus musculus 212-215 12049174-8 2002 CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, clotrimazole and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. Dieldrin 135-143 nuclear receptor subfamily 1, group I, member 2 Mus musculus 217-242 12049174-8 2002 CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, clotrimazole and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. Dieldrin 135-143 nuclear receptor subfamily 3, group C, member 1 Mus musculus 252-275 11527985-4 2001 However, dieldrin was found to increase human neutrophil superoxide production, RNA synthesis, and proinflammatory cytokine interleukin-8 production. Dieldrin 9-17 C-X-C motif chemokine ligand 8 Homo sapiens 124-137 11719704-10 2001 Adolescent exposure to dieldrin also increased DAT binding. Dieldrin 23-31 solute carrier family 6 member 3 Rattus norvegicus 47-50 11705706-6 2001 The objective of this study was to determine the effects of dieldrin exposure on the activity of the enzyme responsible for removing 8-oxodGuo, OGG1, from undifferentiated (untreated with NGF) and differentiated (NGF-treated) PC 12 cells. Dieldrin 60-68 8-oxoguanine DNA glycosylase Rattus norvegicus 144-148 11445065-3 2001 Here we show that several pesticides, including rotenone, dieldrin and paraquat, induce a conformational change in alpha-synuclein and significantly accelerate the rate of formation of alpha-synuclein fibrils in vitro. Dieldrin 58-66 synuclein alpha Homo sapiens 115-130 11445065-3 2001 Here we show that several pesticides, including rotenone, dieldrin and paraquat, induce a conformational change in alpha-synuclein and significantly accelerate the rate of formation of alpha-synuclein fibrils in vitro. Dieldrin 58-66 synuclein alpha Homo sapiens 185-200 11787861-3 2001 In this study, the organochlorine xenobiotics dieldrin and endosulfan, at micromolar concentrations, were found to inhibit gap junction-mediated intercellular communication and induce hypophosphorylation of connexin 43 in cultured rat astrocytes, the predominant cell type in the brain coupled through gap junctions. Dieldrin 46-54 gap junction protein, alpha 1 Rattus norvegicus 207-218 11238185-8 2001 TGFbeta-induced apoptosis of FTO-2B cells was inhibited by dexamethasone, insulin, phenobarbital and dieldrin. Dieldrin 101-109 transforming growth factor, beta 1 Rattus norvegicus 0-7 11238185-8 2001 TGFbeta-induced apoptosis of FTO-2B cells was inhibited by dexamethasone, insulin, phenobarbital and dieldrin. Dieldrin 101-109 FTO, alpha-ketoglutarate dependent dioxygenase Rattus norvegicus 29-32 11787861-5 2001 Chaetoglobosin K also prevented dieldrin and endosulfan-induced hypophosphorylation of connexin 43 and prevented dieldrin-induced connexin 43 plaque dissolution in both astrocytes and cultured liver epithelial cells. Dieldrin 113-121 gap junction protein alpha 1 Homo sapiens 130-141 10653519-3 2000 Therefore, studies were performed to determine if the organochlorine pesticides, lindane and dieldrin, activate neutrophils to produce O2- by a mechanism that requires PLA2. Dieldrin 93-101 phospholipase A2 group IB Homo sapiens 168-172 10847166-2 2000 Weekly sampling of four of these rivers revealed two classes of dieldrin contamination: the Aire and Calder (the rivers which support very high concentrations of wool processing industries) had higher concentrations (averaging approximately 3 ng/l) than the Don and Trent (approximately 1 ng/l). Dieldrin 64-72 autoimmune regulator Ovis aries 92-96 10653519-5 2000 Significant release of 3H-AA was seen in neutrophils stimulated with dieldrin or lindane in calcium-free medium and in the presence of the intracellular calcium chelator BAPTA-AM, suggesting that these agents stimulate a PLA2 that does not require calcium for activation. Dieldrin 69-77 phospholipase A2 group IB Homo sapiens 221-225 10653519-7 2000 These data suggest that dieldrin and lindane stimulate O2- production by a mechanism that involves PLA2. Dieldrin 24-32 phospholipase A2 group IB Homo sapiens 99-103 10653519-9 2000 This suggests that more than one isoform of PLA2 is activated by dieldrin and by lindane, and that one isoform is calcium-dependent. Dieldrin 65-73 phospholipase A2 group IB Homo sapiens 44-48 10200566-1 1999 The effects of the liver tumor promoters phenobarbital, clofibrate, dieldrin, and DDT on transforming growth factor-beta1 (TGFbeta)-induced apoptosis were studied in FTO-2B hepatoma cells. Dieldrin 68-76 transforming growth factor, beta 1 Rattus norvegicus 89-121 10455279-0 1999 Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. Dieldrin 22-30 Resistant to dieldrin Drosophila melanogaster 62-75 10200566-1 1999 The effects of the liver tumor promoters phenobarbital, clofibrate, dieldrin, and DDT on transforming growth factor-beta1 (TGFbeta)-induced apoptosis were studied in FTO-2B hepatoma cells. Dieldrin 68-76 transforming growth factor, beta 1 Rattus norvegicus 123-130 9014156-2 1996 Here, we report the generation of a Drosophila melanogaster cell line (S2-RDLA302S) stably expressing a mutated, dieldrin-resistant (A302S) form of RDL. Dieldrin 113-121 Resistant to dieldrin Drosophila melanogaster 74-77 8625394-1 1996 An antibody raised against a peptide based on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster. Dieldrin 163-171 Resistant to dieldrin Drosophila melanogaster 145-148 9302086-11 1997 Levels of beta3 subunit transcripts were significantly increased (by 300%) by dieldrin, whereas expression of gamma2S and gamma2L transcripts were decreased (by 50% and 40%, respectively). Dieldrin 78-86 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 10-15 9302086-13 1997 Dieldrin appeared to increase expression of alpha1 subunit transcripts, but this effect was not statistically significant. Dieldrin 0-8 adrenoceptor alpha 1D Homo sapiens 44-50 9014156-4 1996 Using these stable lines, a striking reduction in sensitivity to both picrotoxinin and dieldrin was observed for responses to GABA of S2-RDLA302S compared to S2-RDL. Dieldrin 87-95 Resistant to dieldrin Drosophila melanogaster 137-140 7473857-5 1995 In contrast, the chlorinated hydrocarbon pesticides, such as DDT, dieldrin, chlordane, and mirex, cause almost exclusively the induction of isoforms of the CYP2B (and to a lesser extent the CYP3A) subfamilies. Dieldrin 66-74 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 190-195 7582519-7 1995 Mutant RDL GABA-receptors, which have a naturally occurring amino acid substitution (A302-->S) in the putative ion-channel lining region, conferring resistance to dieldrin and picrotoxinin, were markedly less sensitive to fipronil than the wild-type receptors. Dieldrin 166-174 Resistant to dieldrin Drosophila melanogaster 7-10 1904046-1 1991 Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen). Dieldrin 41-49 Resistant to dieldrin Drosophila melanogaster 73-76 8389005-6 1993 Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor. Dieldrin 73-81 Resistant to dieldrin Drosophila melanogaster 55-58 8389005-6 1993 Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor. Dieldrin 73-81 Resistant to dieldrin Drosophila melanogaster 138-151 8062082-4 1994 When co-applied with GABA, dieldrin exerted a dual effect, enhancement and suppression, on the GABA-induced chloride currents in the alpha 1 beta 2 gamma 2s and alpha 6 beta 2 gamma 2s combinations. Dieldrin 27-35 adrenoceptor alpha 1D Homo sapiens 133-140 8062082-5 1994 However, only suppression was observed in the alpha 1 beta 2 combination, indicating that the gamma subunit is necessary for dieldrin"s enhancing effect. Dieldrin 125-133 adrenoceptor alpha 1D Homo sapiens 46-53 8062082-7 1994 Dieldrin suppressed the GABA-induced current in a non-competitive manner, with an EC50 value of 2.1 microM for alpha 1 beta 2 gamma 2s, 2.8 microM for alpha 1 beta 2 and 1.0 microM for alpha 6 beta 2 gamma 2s combination. Dieldrin 0-8 adrenoceptor alpha 1D Homo sapiens 111-118 8062082-7 1994 Dieldrin suppressed the GABA-induced current in a non-competitive manner, with an EC50 value of 2.1 microM for alpha 1 beta 2 gamma 2s, 2.8 microM for alpha 1 beta 2 and 1.0 microM for alpha 6 beta 2 gamma 2s combination. Dieldrin 0-8 adrenoceptor alpha 1D Homo sapiens 151-171 1312398-0 1992 The tumour promoters dieldrin and phenobarbital increase the frequency of c-Ha-ras wild-type, but not of c-Ha-ras mutated focal liver lesions in male C3H/He mice. Dieldrin 21-29 Harvey rat sarcoma virus oncogene Mus musculus 74-82 1904046-1 1991 Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen). Dieldrin 41-49 l(2)46Cc Drosophila melanogaster 108-111 34688840-5 2021 In the present study, the attempt has been made to elucidate the effect of dieldrin on the promoter-specific CYP19A1 gene expression and estrogen hormone production in buffalo granulosa cells. Dieldrin 75-83 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 109-116 34688840-7 2021 Results showed that dieldrin significantly increased the expression of the CYP19A1 gene after 6 and 12 h while its expression was decreased after 24 h. To understand the upregulation of CYP19A1 gene, promoters" specific CYP19A1 transcript analysis was done. Dieldrin 20-28 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 75-82 34688840-7 2021 Results showed that dieldrin significantly increased the expression of the CYP19A1 gene after 6 and 12 h while its expression was decreased after 24 h. To understand the upregulation of CYP19A1 gene, promoters" specific CYP19A1 transcript analysis was done. Dieldrin 20-28 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 186-193 34688840-12 2021 Overall, the present study demonstrated the stimulatory effect of dieldrin on the CYP19A1 gene and will help to understand the toxicological role of dieldrin on the reproductive system. Dieldrin 66-74 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 82-89 34688840-12 2021 Overall, the present study demonstrated the stimulatory effect of dieldrin on the CYP19A1 gene and will help to understand the toxicological role of dieldrin on the reproductive system. Dieldrin 149-157 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 82-89 34688840-0 2021 Organochlorine pesticide dieldrin upregulate proximal promoter (PII) driven CYP19A1 gene expression and increases estrogen production in granulosa cells. Dieldrin 25-33 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 76-83