PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8226633-0	1993	SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors.	beta-Glucans	69-80	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	0-4
8126442-13	1993	CelA hydrolysed barley beta-glucan, lichenan, carboxymethylcellulose and xylan.	beta-Glucans	23-34	kil protein	Escherichia coli	0-4
7505123-3	1993	We have investigated the effect of beta-glucans on the production of interleukin-1 (IL-1) and its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1Ra).	beta-Glucans	35-47	interleukin 1 alpha	Homo sapiens	69-82
7505123-3	1993	We have investigated the effect of beta-glucans on the production of interleukin-1 (IL-1) and its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1Ra).	beta-Glucans	35-47	interleukin 1 alpha	Homo sapiens	84-88
7505123-4	1993	Particulate beta-glucan induced IL-1Ra production from human peripheral blood mononuclear cells (PBMC) but did not stimulate IL-1 beta synthesis or gene expression in these same cells.	beta-Glucans	12-23	interleukin 1 receptor antagonist	Homo sapiens	32-38
7505123-6	1993	However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra.	beta-Glucans	48-59	interleukin 1 receptor antagonist	Homo sapiens	132-138
7505123-6	1993	However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra.	beta-Glucans	48-59	interleukin 1 receptor antagonist	Homo sapiens	230-236
7505123-6	1993	However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra.	beta-Glucans	107-118	interleukin 1 receptor antagonist	Homo sapiens	132-138
7505123-7	1993	In support of this, monomeric beta-glucan immobilized on plastic surfaces stimulated IL-1Ra production.	beta-Glucans	30-41	interleukin 1 receptor antagonist	Homo sapiens	85-91
7505123-8	1993	Vitamin D3, which increases the functional capacity of beta-glucan receptors, increased IL-1Ra production induced by particulate beta-glucan, whereas dexamethasone suppressed IL-1Ra synthesis.	beta-Glucans	55-66	interleukin 1 receptor antagonist	Homo sapiens	88-94
7505123-9	1993	Because of their differential effects on cytokine production, beta-glucans may be used to therapeutic advantage in the diseases in which IL-1 is implicated.	beta-Glucans	62-74	interleukin 1 alpha	Homo sapiens	137-141
8348743-4	1993	The beta-glucan, purified from both strains, increased serum TNF levels in an identical dose-dependent manner, whereas purified chitin did not induce serum TNF levels.	beta-Glucans	4-15	tumor necrosis factor	Mus musculus	61-64
8220493-10	1993	GRP gene expression has previously been associated with disease resistance in plants, but it remains to be determined whether beta-glucan activation of the tobacco GRP gene results in the observed resistance to virus.	beta-Glucans	126-137	glycine-rich protein	Nicotiana tabacum	164-167
8413233-0	1993	The yeast KRE9 gene encodes an O glycoprotein involved in cell surface beta-glucan assembly.	beta-Glucans	71-82	Kre9p	Saccharomyces cerevisiae S288C	10-14
8413233-1	1993	The yeast KRE9 gene encodes a 30-kDa secretory pathway protein involved in the synthesis of cell wall (1-->6)-beta-glucan.	beta-Glucans	113-124	Kre9p	Saccharomyces cerevisiae S288C	10-14
8348743-5	1993	P. brasiliensis, the F1 fractions and beta-glucan induced macrophages to secrete TNF in vitro.	beta-Glucans	38-49	tumor necrosis factor	Mus musculus	81-84
8348743-6	1993	The differences in TNF levels, induced by the different fungal strains, were correlated with the beta-glucan concentrations in the cell walls of both the avirulent and virulent strains of P. brasiliensis.	beta-Glucans	97-108	tumor necrosis factor	Mus musculus	19-22
8485905-5	1993	Soluble beta-glucan derived from the yeast Saccharomyces cerevisiae is a particularly potent stimulator of CR3, and produces an activated state of the receptor that permits neutrophil phagocytosis of iC3b-coated erythrocytes or NK, cell cytotoxicity of iC3b-coated tumour cells, that are normally resistant to NK cells.	beta-Glucans	8-19	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	107-110
8225403-0	1993	Fungal beta-glucans modulate macrophage release of tumor necrosis factor-alpha in response to bacterial lipopolysaccharide.	beta-Glucans	7-19	tumor necrosis factor	Rattus norvegicus	51-78
8225403-2	1993	Treatment of animals with beta-glucan prior to bacterial challenge reduces TNF alpha release and prevents death.	beta-Glucans	26-37	tumor necrosis factor	Rattus norvegicus	75-84
8225403-3	1993	We therefore hypothesized that beta-glucan might regulate TNF alpha secretion from macrophages in response to lipopolysaccharide (LPS).	beta-Glucans	31-42	tumor necrosis factor	Rattus norvegicus	58-67
8225403-5	1993	Concentrations of beta-glucan less than 500 micrograms/ml were found to stimulate TNF alpha release from macrophages.	beta-Glucans	18-29	tumor necrosis factor	Rattus norvegicus	82-91
8225403-6	1993	However, concentrations of beta-glucan greater than 500 micrograms/ml resulted in suppression of the TNF alpha activity released.	beta-Glucans	27-38	tumor necrosis factor	Rattus norvegicus	101-110
8225403-8	1993	We further observed that the incubation of macrophages with large concentrations of beta-glucan (500 micrograms/ml) also inhibited the secretion of TNF alpha induced by bacterial LPS.	beta-Glucans	84-95	tumor necrosis factor	Rattus norvegicus	148-157
8225403-10	1993	These data suggest an immunomodulatory role for beta-glucan which may explain both the TNF alpha-stimulating and -inhibiting effects of fungal beta-glucans during infection.	beta-Glucans	48-59	tumor necrosis factor	Rattus norvegicus	87-96
8225403-10	1993	These data suggest an immunomodulatory role for beta-glucan which may explain both the TNF alpha-stimulating and -inhibiting effects of fungal beta-glucans during infection.	beta-Glucans	143-155	tumor necrosis factor	Rattus norvegicus	87-96
8321211-0	1993	SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis.	beta-Glucans	99-110	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	0-4
8321211-0	1993	SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis.	beta-Glucans	99-110	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	9-13
8321211-1	1993	KRE6 encodes a predicted type II membrane protein which, when disrupted, results in a slowly growing, killer toxin-resistant mutant possessing half the normal level of a structurally wild-type cell wall (1-->6)-beta-glucan (T. Roemer and H. Bussey, Proc.	beta-Glucans	214-225	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	0-4
8321211-6	1993	The mutant phenotype and structure of the KRE6 gene product, Kre6p, suggest that it may be a beta-glucan synthase component, implying that (1-->6)-beta-glucan synthesis in Saccharomyces cerevisiae is functionally redundant.	beta-Glucans	93-104	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	42-46
8321211-6	1993	The mutant phenotype and structure of the KRE6 gene product, Kre6p, suggest that it may be a beta-glucan synthase component, implying that (1-->6)-beta-glucan synthesis in Saccharomyces cerevisiae is functionally redundant.	beta-Glucans	93-104	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	61-66
8321211-9	1993	skn1 kre6 double disruptants, however, showed a dramatic reduction in both (1-->6)-beta-glucan levels and growth rate compared with either single disruptant.	beta-Glucans	86-97	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	0-4
8321211-9	1993	skn1 kre6 double disruptants, however, showed a dramatic reduction in both (1-->6)-beta-glucan levels and growth rate compared with either single disruptant.	beta-Glucans	86-97	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	5-9
8321211-11	1993	Since single disruptions of these genes lead to structurally wild-type (1-->6)-beta-glucan polymers, Kre6p and Skn1p appear to function independently, possibly in parallel, in (1-->6)-beta-glucan biosynthesis.	beta-Glucans	82-93	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	114-119
8321211-11	1993	Since single disruptions of these genes lead to structurally wild-type (1-->6)-beta-glucan polymers, Kre6p and Skn1p appear to function independently, possibly in parallel, in (1-->6)-beta-glucan biosynthesis.	beta-Glucans	190-201	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	104-109
8321211-11	1993	Since single disruptions of these genes lead to structurally wild-type (1-->6)-beta-glucan polymers, Kre6p and Skn1p appear to function independently, possibly in parallel, in (1-->6)-beta-glucan biosynthesis.	beta-Glucans	190-201	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	114-119
8100571-9	1993	When PBMC were incubated with rIFN-alpha, rIL-2, beta-glucan, or high concentrations of LPS, expression of CR3 on NK cells increased significantly, but > or = 4 hr of stimulation was required.	beta-Glucans	49-60	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	107-110
8364464-6	1993	In addition, the administration of beta-glucan in vivo elevated the concentration of FN in serum by acute phase response and enhanced GIZUP, suggesting the positive contribution of acute phase responses on beta-glucan mediated immunopharmacological activities.	beta-Glucans	35-46	fibronectin 1	Mus musculus	85-87
8462845-4	1993	Structural analysis of the (1-->6)-beta-glucan remaining in a kre11 mutant indicates a polymer smaller in size than wild type, but containing a similar proportion of (1-->6)- and (1-->3)-linkages.	beta-Glucans	38-49	Trs65p	Saccharomyces cerevisiae S288C	65-70
8364464-6	1993	In addition, the administration of beta-glucan in vivo elevated the concentration of FN in serum by acute phase response and enhanced GIZUP, suggesting the positive contribution of acute phase responses on beta-glucan mediated immunopharmacological activities.	beta-Glucans	206-217	fibronectin 1	Mus musculus	85-87
1481998-3	1992	The results of the specific actions of alpha- and beta-glucosidases showed that the non-dialysable urinary glucoconjugates contain a branched alpha-glucan fraction with 1,4- and 1,6-glucosidic bonds, and a beta-glucan fraction containing 1,4-glucosidic bonds.	beta-Glucans	206-217	sucrase-isomaltase	Homo sapiens	39-67
1938890-0	1991	Isolation from Candida albicans of a functional homolog of the Saccharomyces cerevisiae KRE1 gene, which is involved in cell wall beta-glucan synthesis.	beta-Glucans	130-141	Kre1p	Saccharomyces cerevisiae S288C	88-92
1837148-0	1991	Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro.	beta-Glucans	6-17	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	29-33
1837148-1	1991	The KRE6 gene product is required for synthesis of the major beta-glucans of the yeast cell wall, as mutations in this gene confer reduced levels of both the (1----6)- and (1----3)-beta-D-glucan polymers.	beta-Glucans	61-73	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	4-8
1837148-9	1991	Use of KRE6 should permit a genetic analysis of eukaryotic (1----3)-beta-glucan synthesis.	beta-Glucans	68-79	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	7-11
1839761-4	1991	In contrast, acr1, acr3, and acr4 mutants were resistant to papulacandin B (an antibiotic containing a disaccharide linked to two fatty acid chains that also inhibits beta-glucan synthesis), but acr2 mutants were susceptible to this antibiotic.	beta-Glucans	167-178	Arr1p	Saccharomyces cerevisiae S288C	13-17
1839761-4	1991	In contrast, acr1, acr3, and acr4 mutants were resistant to papulacandin B (an antibiotic containing a disaccharide linked to two fatty acid chains that also inhibits beta-glucan synthesis), but acr2 mutants were susceptible to this antibiotic.	beta-Glucans	167-178	Arr3p	Saccharomyces cerevisiae S288C	19-23
1938890-1	1991	The KRE1 gene of Saccharomyces cerevisiae, sacKRE1, appears to be involved in the synthesis of cell wall beta-glucan.	beta-Glucans	105-116	Kre1p	Saccharomyces cerevisiae S288C	4-8
2005733-9	1991	A dose-dependent reduction in LDL-C levels with oat cereals supports the independent hypocholesterolemic effects of beta-glucan.	beta-Glucans	116-127	component of oligomeric golgi complex 2	Homo sapiens	30-35
2060581-0	1991	The function of human NK cells is enhanced by beta-glucan, a ligand of CR3 (CD11b/CD18).	beta-Glucans	46-57	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	71-74
2060581-0	1991	The function of human NK cells is enhanced by beta-glucan, a ligand of CR3 (CD11b/CD18).	beta-Glucans	46-57	integrin subunit alpha M	Homo sapiens	76-81
2060581-0	1991	The function of human NK cells is enhanced by beta-glucan, a ligand of CR3 (CD11b/CD18).	beta-Glucans	46-57	integrin subunit beta 2	Homo sapiens	82-86
2060581-2	1991	In addition to the iC3b binding site the CR3 molecules possess an epitope which binds beta-glucan.	beta-Glucans	86-97	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	41-44
2060581-6	1991	The monoclonal antibody OKM-1, directed to the beta-glucan-binding site of CR3, abrogated this effect.	beta-Glucans	47-58	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	75-78
2155276-7	1990	Cytochalasin B, which enhances degranulation and fMLP-stimulated superoxide production, was found to inhibit beta-glucan particle-stimulated superoxide production.	beta-Glucans	109-120	formyl peptide receptor 1	Homo sapiens	49-53
2356188-3	1990	In this work, it is shown that beta-glucan and several pectin derivatives are able to stimulate prolactin secretion from hypophysis fragments incubated for 2 hr in a synthetic medium.	beta-Glucans	31-42	prolactin	Homo sapiens	96-105
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	beta-Glucans	34-45	angiotensin converting enzyme 2	Homo sapiens	93-97
33794269-3	2021	Specifically, murine colorectal cancer cells MC38 lysate and Toll-like receptor 9 agonist CpG are loaded into yeast derived beta-glucan particles (GPs).	beta-Glucans	124-135	toll-like receptor 9	Mus musculus	61-81
33233118-3	2020	Using RT-qPCR and rhythmicity analysis, our study revealed that beta-glucan (0.2 g/day) and inulin (0.2 g/day) modulated the expression and phase of circadian-clock genes, explicitly reversed the phase delay of Period 1 and Period 3 in the hypothalamus, and reversed the phase delay of Period 2 in the liver of the mice.	beta-Glucans	64-75	period circadian clock 2	Mus musculus	286-294
34896749-2	2022	Dectin-1, one of the major receptors for beta-glucans, is known to be expressed on antigen presenting cells (APCs) such as macrophages and dendritic cells.	beta-Glucans	41-53	C-type lectin domain family 7, member a	Mus musculus	0-8
33771629-15	2021	The data suggest that exposure to molecules from P. brasiliensis, as beta-glucans, is needed to induce IL-32 production since only heat-killed and sonicated P. brasiliensis yeasts were able to increase IL-32, which was blocked by anti-Dectin-1 antibodies.	beta-Glucans	69-81	interleukin 32	Homo sapiens	103-108
33771629-15	2021	The data suggest that exposure to molecules from P. brasiliensis, as beta-glucans, is needed to induce IL-32 production since only heat-killed and sonicated P. brasiliensis yeasts were able to increase IL-32, which was blocked by anti-Dectin-1 antibodies.	beta-Glucans	69-81	interleukin 32	Homo sapiens	202-207
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	beta-Glucans	47-58	angiotensin converting enzyme 2	Homo sapiens	93-97
34798183-0	2021	Barley beta-glucan resist oxidative stress of Caenorhabditis elegans via daf-2/daf-16 pathway.	beta-Glucans	7-18	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	73-78
34817219-8	2021	These support the twisted conformation of the beta-glucan backbone imposed by the beta1,3 linkages and explain the dependency on the oligosaccharide chain length.	beta-Glucans	46-57	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	82-89
34798183-0	2021	Barley beta-glucan resist oxidative stress of Caenorhabditis elegans via daf-2/daf-16 pathway.	beta-Glucans	7-18	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	79-85
34798183-7	2021	The CB1370 and CF1038 mutants further confirmed that daf-2 and daf-16 were necessary for FBG or RBG to participate in anti-oxidative stress, and the RT-PCR results also evidenced that beta-glucans resist oxidative stress in C. elegans partially through the daf-2/daf-16 pathway.	beta-Glucans	184-196	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	257-262
34798183-7	2021	The CB1370 and CF1038 mutants further confirmed that daf-2 and daf-16 were necessary for FBG or RBG to participate in anti-oxidative stress, and the RT-PCR results also evidenced that beta-glucans resist oxidative stress in C. elegans partially through the daf-2/daf-16 pathway.	beta-Glucans	184-196	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	263-269
34850023-6	2022	In comparison to controls, patients with CPA had significantly reduced production of IFNgamma in response to stimulation with beta-glucan+IL-12 (312 vs 988 pg/ml), LPS+IL-12 (252 vs 1033 pg/ml), ZYM+IL-12 (996 vs 2347 pg/ml), and IL-18+IL-12 (7193 vs 12330 pg/ml).	beta-Glucans	126-137	interferon gamma	Homo sapiens	85-93
34944886-1	2021	Beta glucans, complex polysaccharides, prime leukocyte dectin-1 and CR3-receptors and enhance anti-tumor cytotoxicity of complement-activating monoclonal antibodies.	beta-Glucans	0-12	C-type lectin domain containing 7A	Homo sapiens	55-63
34897972-7	2022	OatN is taken up by microglial cells via beta-glucan mediated binding to microglial hippocalcin (HPCA) whereas oatN digalactosyldiacylglycerol (DGDG) prevents assess of oatN beta-glucan to dectin-1.	beta-Glucans	41-52	hippocalcin	Mus musculus	84-95
34897972-7	2022	OatN is taken up by microglial cells via beta-glucan mediated binding to microglial hippocalcin (HPCA) whereas oatN digalactosyldiacylglycerol (DGDG) prevents assess of oatN beta-glucan to dectin-1.	beta-Glucans	174-185	C-type lectin domain family 7, member a	Mus musculus	189-197
34897972-8	2022	Subsequently endocytosed beta-glucan/HPCA is recruited in an endosomal recycling compartment (ERC) via interaction with Rab11a.	beta-Glucans	25-36	RAB11A, member RAS oncogene family	Mus musculus	120-126
34897972-9	2022	This complex then sequesters the dectin-1 in the ERC in an oatN beta-glucan dependent manner and alters the location of dectin-1 from Golgi to early endosomes and lysosomes and increases exportation of dectin-1 into exosomes in an Rab11a dependent manner.	beta-Glucans	64-75	C-type lectin domain family 7, member a	Mus musculus	33-41
34894475-4	2021	Gclc deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of c-Myc transcription factors, abrogating the energy utilization and the metabolic reprogramming that allows beta-glucan-trained macrophages to switch to glycolysis and glutaminolysis.	beta-Glucans	210-221	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-108
34786507-6	2021	Compared with the control group, beta-glucan tended to increase the occludin mRNA expression in the jejunum (0.05 < P < 0.10).	beta-Glucans	33-44	occludin	Sus scrofa	68-76
34166798-7	2021	Translocation of mycobiotal antigens like curdlan (beta-glucan), which plays a major role in the pathogenesis of SpA in the SGK mice, has been observed in humans.	beta-Glucans	51-62	surfactant associated protein A1	Mus musculus	113-116
34166798-7	2021	Translocation of mycobiotal antigens like curdlan (beta-glucan), which plays a major role in the pathogenesis of SpA in the SGK mice, has been observed in humans.	beta-Glucans	51-62	serum/glucocorticoid regulated kinase 1	Mus musculus	124-127
33779504-7	2021	Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis.	beta-Glucans	135-146	lectin, galactose binding, soluble 3	Mus musculus	50-55
34894475-3	2021	Here, we report that beta-glucan-trained macrophages from mice harboring a myeloid-specific deletion of the catalytic subunit of glutamate-cysteine ligase (Gclc) showed impaired GSH synthesis and decreased proinflammatory cytokine production in response to lipopolysaccharide challenge.	beta-Glucans	21-32	glutamate-cysteine ligase, catalytic subunit	Mus musculus	156-160
34894475-4	2021	Gclc deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of c-Myc transcription factors, abrogating the energy utilization and the metabolic reprogramming that allows beta-glucan-trained macrophages to switch to glycolysis and glutaminolysis.	beta-Glucans	210-221	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-4
34894475-4	2021	Gclc deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of c-Myc transcription factors, abrogating the energy utilization and the metabolic reprogramming that allows beta-glucan-trained macrophages to switch to glycolysis and glutaminolysis.	beta-Glucans	210-221	mechanistic target of rapamycin kinase	Homo sapiens	46-77
34894475-4	2021	Gclc deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of c-Myc transcription factors, abrogating the energy utilization and the metabolic reprogramming that allows beta-glucan-trained macrophages to switch to glycolysis and glutaminolysis.	beta-Glucans	210-221	mechanistic target of rapamycin kinase	Homo sapiens	79-83
34850023-7	2022	Age >60 (p=0.05, HR 1.71, 95%CI 1.00-2.91) and COPD (p=0.039, HR 1.69, 95%CI 1.03-2.78) were associated with worse survival, whereas high IFNgamma production in response to beta-glucan+IL-12 stimulation (p=0.026, HR 0.48, 95%CI 0.25-0.92) was associated with reduced mortality.	beta-Glucans	173-184	interferon gamma	Homo sapiens	138-146
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	beta-Glucans	18-29	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	247-255
34837152-2	2022	The formation of covalent links between chitin and beta-glucans is catalyzed by the enzymes Crh1 and Crh2, acting as transglycosylases.	beta-Glucans	51-63	transglycosylase	Saccharomyces cerevisiae S288C	92-96
34837152-2	2022	The formation of covalent links between chitin and beta-glucans is catalyzed by the enzymes Crh1 and Crh2, acting as transglycosylases.	beta-Glucans	51-63	Utr2p	Saccharomyces cerevisiae S288C	101-105
34837152-5	2022	Inhibition of Crh1 and Crh2 in vivo with oligosaccharides derived from chitin leads to an increase of alkali-soluble chitin and a decrease in the amount of chitin linked to beta-glucans.	beta-Glucans	173-185	transglycosylase	Saccharomyces cerevisiae S288C	14-18
34837152-5	2022	Inhibition of Crh1 and Crh2 in vivo with oligosaccharides derived from chitin leads to an increase of alkali-soluble chitin and a decrease in the amount of chitin linked to beta-glucans.	beta-Glucans	173-185	Utr2p	Saccharomyces cerevisiae S288C	23-27
34601443-7	2021	Both the LPS and beta-glucan maternal treatments resulted in transgenerational effects on blood-derived monocytes by showing a tendency of decreased IL1beta mRNA levels after ex vivo LPS stimulation.	beta-Glucans	17-28	interleukin 1, beta	Gallus gallus	149-156
34443340-0	2021	Effect of Oat beta-Glucan on the Rheological Characteristics and Microstructure of Set-Type Yogurt.	beta-Glucans	14-25	ornithine aminotransferase	Homo sapiens	10-13
34828792-0	2021	Appetite and Satiety Effects of the Acute and Regular Consumption of Green Coffee Phenols and Green Coffee Phenol/Oat beta-Glucan Nutraceuticals in Subjects with Overweight and Obesity.	beta-Glucans	118-129	ornithine aminotransferase	Homo sapiens	114-117
34828792-2	2021	Therefore, the influence on appetite/satiety of acute and regular consumption of two nutraceuticals, a decaffeinated green coffee phenolic extract (GC) alone or combined with oat beta-glucans (GC/BG), with known satiating properties, has been analysed subjectively using visual analog scales (VAS) and objectively measuring actual food intake and postprandial appetite and satiety hormones.	beta-Glucans	179-191	ornithine aminotransferase	Homo sapiens	175-178
34392134-1	2021	Bottom-up synthesis of beta-glucans such as callose, fungal beta-(1,3)(1,6)-glucan and cellulose, can create the defined compounds that are needed to perform fundamental studies on glucan properties and develop applications.	beta-Glucans	23-35	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	60-69
34489167-2	2021	Dectin-1 recognizes beta-glucans and elicits antifungal proinflammatory immune responses.	beta-Glucans	20-32	C-type lectin domain containing 7A	Homo sapiens	0-8
34579130-5	2021	Compared with water-soluble beta-glucan, water-insoluble beta-glucan had higher DP3:DP4 molar ratio (2.12 and 1.67, respectively) and molecular weight (123,800 and 119,200 g/mol, respectively).	beta-Glucans	28-39	transcription factor Dp 2	Mus musculus	80-83
34579130-5	2021	Compared with water-soluble beta-glucan, water-insoluble beta-glucan had higher DP3:DP4 molar ratio (2.12 and 1.67, respectively) and molecular weight (123,800 and 119,200 g/mol, respectively).	beta-Glucans	57-68	transcription factor Dp 2	Mus musculus	80-83
34237364-0	2021	Oat beta-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.	beta-Glucans	4-15	C-type lectin domain containing 7A	Homo sapiens	104-112
34237364-0	2021	Oat beta-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.	beta-Glucans	4-15	mitogen-activated protein kinase 1	Homo sapiens	122-125
34237364-0	2021	Oat beta-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.	beta-Glucans	4-15	mitogen-activated protein kinase 14	Homo sapiens	130-133
34828872-3	2021	Beta-glucan is an important component of dietary fiber found in oat grains.	beta-Glucans	0-11	ornithine aminotransferase	Homo sapiens	64-67
34391940-5	2021	This demonstrates the trade-off presented by the head kidney and spleen after immunostimulation in order to produce acquired immunity, as well as an increase in HSP70 expression in vaccinated + beta-glucan fish.	beta-Glucans	194-205	heat shock cognate 71 kDa protein	Oreochromis niloticus	161-166
34119170-4	2021	Oat beta-glucan reversed the increase in body weight, liver weight-to-body weight ratio and plasma leptin concentration as well as restored glucose tolerance.	beta-Glucans	4-15	leptin	Mus musculus	99-105
34213612-8	2021	beta-Glucan extracted from I-6 also induced higher levels of IL-10 production in BMDCs than beta-glucan from Sc.	beta-Glucans	0-11	interleukin 10	Mus musculus	61-66
34237364-0	2021	Oat beta-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.	beta-Glucans	4-15	calcium sensing receptor	Homo sapiens	91-95
34443340-1	2021	The oat beta-glucan (OG) was added into set-type yogurt as a functional ingredient, in order to evaluate effects on the rheological characteristics and microstructure of set-type yogurt.	beta-Glucans	8-19	ornithine aminotransferase	Homo sapiens	4-7
34295335-0	2021	GAS1: A New beta-Glucan Immunostimulant Candidate to Increase Rainbow Trout (Oncorhynchus mykiss) Resistance to Bacterial Infections With Aeromonas salmonicida achromogenes.	beta-Glucans	12-23	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	0-4
34196548-0	2021	Seeking Aggregation-Induced Emission Materials in Food: Oat beta-Glucan and Its Diverse Applications.	beta-Glucans	60-71	ornithine aminotransferase	Homo sapiens	56-59
34196548-2	2021	Here, we report a non-conjugated biomass material, oat beta-glucan (oat-beta-Glu), which actually does not emit light in a dilute solution but emits significantly when forming aggregates.	beta-Glucans	55-66	ornithine aminotransferase	Homo sapiens	51-54
34196548-2	2021	Here, we report a non-conjugated biomass material, oat beta-glucan (oat-beta-Glu), which actually does not emit light in a dilute solution but emits significantly when forming aggregates.	beta-Glucans	55-66	ornithine aminotransferase	Homo sapiens	68-71
34295335-3	2021	In this study, the immunostimulant effects of two beta-glucan types extracted from wild-type baker"s yeast (Saccharomyces cerevisiae) and its null-mutant Gas1 were investigated.	beta-Glucans	50-61	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	154-158
34208433-3	2021	In the present study, the effects of four dietary fibers (fructose-oligosaccharides, pectin, beta-glucan and arabinoxylan) on the modulation of C3G fermentation patterns were investigated through in vitro fermentation inoculated with human feces.	beta-Glucans	93-104	Rap guanine nucleotide exchange factor 1	Homo sapiens	144-147
34215291-8	2021	Growth characterization of 40 CAZyme-rich yeasts revealed no cellulolytic yeasts, but several species from the Trichomonascaceae and CUG-Ser1 clades were able to grow on xylan, mixed-linkage beta-glucan and xyloglucan.	beta-Glucans	191-202	O-phospho-L-serine:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	137-141
35578615-9	2022	Fasting PYY increased with both medium and high beta-glucan meal compared to the low beta-glucan meal.	beta-Glucans	48-59	peptide YY	Homo sapiens	8-11
34200882-5	2021	Some beta-glucans have been shown to improve gut health, to increase the flow of new immunocytes, increase macrophage function, stimulate phagocytosis, affect intestinal morphology, enhance goblet cell number and mucin-2 production, induce the increased expression of intestinal tight-junctions, and function as effective anti-inflammatory immunomodulators in poultry.	beta-Glucans	5-17	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	213-220
34149707-0	2021	Continuous Exposure to Non-Soluble beta-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages.	beta-Glucans	35-47	colony stimulating factor 1	Homo sapiens	76-81
34149707-5	2021	In addition, trained immunity effects were related to pattern recognition receptor usage, to which end, we analyzed beta-glucan-mediated Dectin-1 activation.	beta-Glucans	116-127	C-type lectin domain containing 7A	Homo sapiens	137-145
34069081-1	2021	Our aim was to determine whether polyphosphazene (PCEP), Curdlan (beta-glucan, a dectin-1 agonist), and Leptin could act as adjuvants to promote a Th17-type adaptive immune response in mice.	beta-Glucans	66-77	C-type lectin domain family 7, member a	Mus musculus	81-89
34062937-0	2021	Effect of Oat beta-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains.	beta-Glucans	14-25	ornithine aminotransferase	Homo sapiens	10-13
34062937-2	2021	We assessed non-GI symptoms in a trial of the LDL-cholesterol lowering effect of oat beta-glucan (OBG).	beta-Glucans	85-96	ornithine aminotransferase	Homo sapiens	81-84
35486318-8	2022	Furthermore, administration of BRD5529 prior to the intratracheal inoculation of fungal beta-glucans, which are known proinflammatory mediators via the Dectin-1-CARD9 pathway, resulted in significant reductions in lung tissue interleukin-6 and tumor necrosis factor-alpha, suggesting the exciting possibility of the use of this CARD9 inhibitor as an additional therapeutic tool in fungal infections.	beta-Glucans	88-100	C-type lectin domain family 7, member a	Mus musculus	152-160
35486318-8	2022	Furthermore, administration of BRD5529 prior to the intratracheal inoculation of fungal beta-glucans, which are known proinflammatory mediators via the Dectin-1-CARD9 pathway, resulted in significant reductions in lung tissue interleukin-6 and tumor necrosis factor-alpha, suggesting the exciting possibility of the use of this CARD9 inhibitor as an additional therapeutic tool in fungal infections.	beta-Glucans	88-100	caspase recruitment domain family, member 9	Mus musculus	161-166
35486318-8	2022	Furthermore, administration of BRD5529 prior to the intratracheal inoculation of fungal beta-glucans, which are known proinflammatory mediators via the Dectin-1-CARD9 pathway, resulted in significant reductions in lung tissue interleukin-6 and tumor necrosis factor-alpha, suggesting the exciting possibility of the use of this CARD9 inhibitor as an additional therapeutic tool in fungal infections.	beta-Glucans	88-100	interleukin 6	Mus musculus	226-239
35486318-8	2022	Furthermore, administration of BRD5529 prior to the intratracheal inoculation of fungal beta-glucans, which are known proinflammatory mediators via the Dectin-1-CARD9 pathway, resulted in significant reductions in lung tissue interleukin-6 and tumor necrosis factor-alpha, suggesting the exciting possibility of the use of this CARD9 inhibitor as an additional therapeutic tool in fungal infections.	beta-Glucans	88-100	tumor necrosis factor	Mus musculus	244-271
35486318-8	2022	Furthermore, administration of BRD5529 prior to the intratracheal inoculation of fungal beta-glucans, which are known proinflammatory mediators via the Dectin-1-CARD9 pathway, resulted in significant reductions in lung tissue interleukin-6 and tumor necrosis factor-alpha, suggesting the exciting possibility of the use of this CARD9 inhibitor as an additional therapeutic tool in fungal infections.	beta-Glucans	88-100	caspase recruitment domain family, member 9	Mus musculus	328-333
35225131-0	2022	Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in beta-glucan induced airway inflammation.	beta-Glucans	81-92	caspase 1	Mus musculus	0-9
35225131-0	2022	Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in beta-glucan induced airway inflammation.	beta-Glucans	81-92	interleukin 17A	Mus musculus	54-59
35225131-0	2022	Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in beta-glucan induced airway inflammation.	beta-Glucans	81-92	interleukin 22	Mus musculus	63-68
35225131-7	2022	Caspase-1 inhibited bone marrow derived dendritic cells (BMDCs), co-cultured with T cells showed decreased T-cell proliferation and direct them to secrete high TGF-beta and IL-10 compared to the T cells co-cultured with beta-glucan primed dendritic cells.	beta-Glucans	220-231	caspase 1	Mus musculus	0-9
35225131-9	2022	Caspase-1 inhibition in intranasal beta-glucan administered mice showed decreased tissue damage, immune cell infiltration and IgA secretion compared to control mice.	beta-Glucans	35-46	caspase 1	Mus musculus	0-9
35225131-10	2022	Further, splenocytes challenged with beta-glucan show high IL-10 secretion and increased FOXp3 and Ahr indicating an increase in regulatory T cells on caspase-1 inhibition.	beta-Glucans	37-48	interleukin 10	Mus musculus	59-64
35225131-10	2022	Further, splenocytes challenged with beta-glucan show high IL-10 secretion and increased FOXp3 and Ahr indicating an increase in regulatory T cells on caspase-1 inhibition.	beta-Glucans	37-48	forkhead box P3	Mus musculus	89-94
35225131-10	2022	Further, splenocytes challenged with beta-glucan show high IL-10 secretion and increased FOXp3 and Ahr indicating an increase in regulatory T cells on caspase-1 inhibition.	beta-Glucans	37-48	aryl-hydrocarbon receptor	Mus musculus	99-102
35225131-10	2022	Further, splenocytes challenged with beta-glucan show high IL-10 secretion and increased FOXp3 and Ahr indicating an increase in regulatory T cells on caspase-1 inhibition.	beta-Glucans	37-48	caspase 1	Mus musculus	151-160
35225131-11	2022	CONCLUSION: Caspase-1 inhibition can thus be an attractive target to prevent inflammation mediated tissue damage during Aspergillus fumigatus mouse model and can be explored as an attractive therapeutic strategy.HIGHLIGHTSCaspase-1 inhibition protects lung damage from inflammation during beta-glucan exposureCaspase-1 inhibition in dendritic cells decreases IL-1beta production resulting in decreased pathogenic Th17Caspase-1 inhibition promotes regulatory T cells thereby inhibiting lung inflammation.	beta-Glucans	289-300	caspase 1	Mus musculus	12-21
34122455-0	2021	Dectin-1-Mediated Production of Pro-Inflammatory Cytokines Induced by Yeast beta-Glucans in Bovine Monocytes.	beta-Glucans	76-88	C-type lectin domain containing 7A	Bos taurus	0-8
34122455-2	2021	beta-glucans are mainly recognized by the cell surface receptor CLEC7A, also designated Dectin-1.	beta-Glucans	0-12	C-type lectin domain containing 7A	Bos taurus	64-70
34122455-2	2021	beta-glucans are mainly recognized by the cell surface receptor CLEC7A, also designated Dectin-1.	beta-Glucans	0-12	C-type lectin domain containing 7A	Bos taurus	88-96
34122455-8	2021	Overall, we demonstrated here that bovine monocytes respond to particulate beta-glucans, through Dectin-1, by increasing the expression of pro-inflammatory cytokines.	beta-Glucans	75-87	C-type lectin domain containing 7A	Bos taurus	97-105
35367515-4	2022	We also show that larvae injected with beta-glucan, the well-known trigger of trained immunity, demonstrate enhanced survival to similar live bacterial infections, a phenotype supported by increased cxcl8 expression and neutrophil recruitment to the infection site.	beta-Glucans	39-50	chemokine (C-X-C motif) ligand 8a	Danio rerio	199-204
35569678-0	2022	Yeast beta-glucan mediates histone deacetylase 5-induced angiogenesis in vascular endothelial cells.	beta-Glucans	6-17	histone deacetylase 5	Homo sapiens	27-48
35569678-2	2022	Therefore, this study investigated the correlation between beta-glucan and histone deacetylase 5 (HDAC5) in human umbilical vein endothelial cells (HUVECs), revealing the role of beta-glucan in angiogenesis.	beta-Glucans	59-70	histone deacetylase 5	Homo sapiens	98-103
35569678-3	2022	We confirmed that HDAC5 was phosphorylated by beta-glucan stimulation and released from the nucleus to the cytoplasm.	beta-Glucans	46-57	histone deacetylase 5	Homo sapiens	18-23
35569678-4	2022	Furthermore, we found that beta-glucan-stimulated HDAC5 translocation mediates the transcriptional activation of MEF2.	beta-Glucans	27-38	histone deacetylase 5	Homo sapiens	50-55
35569678-4	2022	Furthermore, we found that beta-glucan-stimulated HDAC5 translocation mediates the transcriptional activation of MEF2.	beta-Glucans	27-38	Mef2p	Saccharomyces cerevisiae S288C	113-117
35569678-8	2022	HDAC5 inhibitor LMK235 inhibited the proangiogenic activity of beta-glucan, suggesting that beta-glucan induces angiogenesis through HDAC5.	beta-Glucans	63-74	histone deacetylase 5	Homo sapiens	0-5
35569678-8	2022	HDAC5 inhibitor LMK235 inhibited the proangiogenic activity of beta-glucan, suggesting that beta-glucan induces angiogenesis through HDAC5.	beta-Glucans	63-74	histone deacetylase 5	Homo sapiens	133-138
35569678-8	2022	HDAC5 inhibitor LMK235 inhibited the proangiogenic activity of beta-glucan, suggesting that beta-glucan induces angiogenesis through HDAC5.	beta-Glucans	92-103	histone deacetylase 5	Homo sapiens	0-5
35569678-8	2022	HDAC5 inhibitor LMK235 inhibited the proangiogenic activity of beta-glucan, suggesting that beta-glucan induces angiogenesis through HDAC5.	beta-Glucans	92-103	histone deacetylase 5	Homo sapiens	133-138
35569678-10	2022	In conclusion, this study demonstrates that beta-glucan induces angiogenesis through HDAC5.	beta-Glucans	44-55	histone deacetylase 5	Homo sapiens	85-90
35388002-3	2022	Dectin-1 is a PRR for fungal beta-glucans on immune cells that is rapidly internalised after ligand-binding.	beta-Glucans	29-41	C-type lectin domain containing 7A	Homo sapiens	0-8
35403253-3	2022	Through this article, we wish to emphasize that beta-glucans not only enhance the innate immunity but also possess the capability to modulate all the arms of the immunity viz., innate, adaptive, TRIM at different sites including those postulated to be the entry site of the SARS-CoV2.	beta-Glucans	48-60	T cell receptor associated transmembrane adaptor 1	Homo sapiens	195-199
35548349-7	2022	These findings suggest that beta-glucan could be used as an immune adjuvant to reverse anti-PD-1/PD-L1 resistance by regulating the immune system.	beta-Glucans	28-39	programmed cell death 1	Homo sapiens	92-96
35548349-7	2022	These findings suggest that beta-glucan could be used as an immune adjuvant to reverse anti-PD-1/PD-L1 resistance by regulating the immune system.	beta-Glucans	28-39	CD274 molecule	Homo sapiens	97-102
35453270-7	2022	Interestingly, BGL significantly increased the duodenal, jejunal and ileal villus height, and increased the jejunal ratio of villus height to crypt depth (V/C) upon ETEC challenge (p < 0.05).	beta-Glucans	15-18	ETEC	Sus scrofa	165-169
35330235-2	2022	The GPH1 gene is a putative glycogen phosphorylase because its Saccharomyces cerevisiae homolog participates in glycogen catabolism, which involves the synthesis of beta-glucan of the fungal cell wall.	beta-Glucans	165-176	glycogen phosphorylase	Saccharomyces cerevisiae S288C	28-50
35330265-8	2022	Blood samples of 14 and 10 patients in the beta-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-gamma cytokines.	beta-Glucans	43-54	interleukin 4	Homo sapiens	241-245
35330265-8	2022	Blood samples of 14 and 10 patients in the beta-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-gamma cytokines.	beta-Glucans	43-54	interleukin 17A	Homo sapiens	247-252
35330265-12	2022	There was a significant difference in IL-4 secretion between the beta-glucan and control groups after adjusting for potential confounders/covariates (MD = 77.27; 95% CI: 44.73 to 109.82; Cohen"s d = 2.21; 95% CI: 1.16 to 3.24; p = 0.0001).	beta-Glucans	65-76	interleukin 4	Homo sapiens	38-42
35330265-13	2022	The results indicate that 5% (m/m) of beta-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving beta-glucan.	beta-Glucans	38-49	interleukin 4	Homo sapiens	141-145
35330265-13	2022	The results indicate that 5% (m/m) of beta-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving beta-glucan.	beta-Glucans	162-173	interleukin 4	Homo sapiens	141-145
35309341-6	2022	IL-32 also determines the transcriptional profile in the bone marrow progenitor cells to mediate the trained immunity induced by beta-glucan and BCG, thereby contributing to the resistance against Leishmania.	beta-Glucans	129-140	interleukin 32	Homo sapiens	0-5
35215555-6	2022	beta-glucan also increases the activity of antioxidant enzymes GSH-PX and SOD, and reduces the level of MDA in the serum.	beta-Glucans	0-11	superoxide dismutase 1	Homo sapiens	74-77
34289046-4	2022	Ephrin type-A receptor (EphA2), has been previously identified as a lung epithelial pattern recognition receptor (PRR) that binds to fungal beta-glucans.	beta-Glucans	140-152	EPH receptor A2	Homo sapiens	24-29
34998984-6	2022	However, beta-glucan might participate in immunomodulation through C-type lectin receptor (CLR) and complement receptor 3 (CR3) to suppress pro-inflammatory responses, thereby revered all the copper induced aforementioned adverse effects in MO/MPhi.	beta-Glucans	9-20	C-type lectin domain family 17, member A	Oreochromis niloticus	67-89
34998984-6	2022	However, beta-glucan might participate in immunomodulation through C-type lectin receptor (CLR) and complement receptor 3 (CR3) to suppress pro-inflammatory responses, thereby revered all the copper induced aforementioned adverse effects in MO/MPhi.	beta-Glucans	9-20	C-type lectin domain family 17, member A	Oreochromis niloticus	91-94
35115604-6	2022	Among the 181 compounds tested, one compound showed suppressive effects, while 2 compounds showed promoting effects on BG-trained TNFalpha production.	beta-Glucans	119-121	tumor necrosis factor	Homo sapiens	130-138
35115604-10	2022	In trained immunity, the histone lysine methyltransferase SETD7 was identified, and its expression was increased during BG treatment.	beta-Glucans	120-122	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	58-63
34289046-5	2022	Herein, we also report that EphA2 can also bind Pneumocystis beta-glucans, both in isolated forms and also on exposed surfaces of the organism.	beta-Glucans	61-73	EPH receptor A2	Homo sapiens	28-33
34289046-7	2022	Indeed, we also show that IL-6 cytokine is significantly increased when lung epithelial cells are exposed to Pneumocystis beta-glucans, and that this response could be blocked with preincubation with a specific antibody to EphA2.	beta-Glucans	122-134	interleukin 6	Homo sapiens	26-30
34289046-7	2022	Indeed, we also show that IL-6 cytokine is significantly increased when lung epithelial cells are exposed to Pneumocystis beta-glucans, and that this response could be blocked with preincubation with a specific antibody to EphA2.	beta-Glucans	122-134	EPH receptor A2	Homo sapiens	223-228
3040332-0	1987	Specificity of membrane complement receptor type three (CR3) for beta-glucans.	beta-Glucans	65-77	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	56-59
35073792-8	2022	SOD, CAT, GPx activities and GSH levels were increased in the TCDD + beta-glucan group.	beta-Glucans	69-80	catalase	Rattus norvegicus	5-8
35054804-2	2022	Submerged cultures and extracts of C. lacerata mycelia (CLM) have been reported to contain various active ingredients, including beta-glucan and extracellular polysaccharides, and to exert anti-diabetogenic properties in mice and cell lines.	beta-Glucans	129-140	CD300C molecule 2	Mus musculus	56-59
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	C-type lectin domain family 7, member a	Mus musculus	61-69
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	CD80 antigen	Mus musculus	96-103
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	interleukin 6	Mus musculus	119-123
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	interleukin 1 alpha	Mus musculus	125-133
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	interferon alpha	Mus musculus	135-143
35215831-5	2022	The results show that beta-glucans induced the expression of Dectin-1, costimulatory molecules (CD80/86) and cytokines IL-6, IL-1beta, IFN-beta and IL-10 in murine bone marrow dendritic cells (BMDCs).	beta-Glucans	22-34	interleukin 10	Mus musculus	148-153
35163449-5	2022	The XTT tests revealed that all beta-glucans were non-toxic for both cell lines and activated PMA-THP-1 cells" metabolisms.	beta-Glucans	32-44	GLI family zinc finger 2	Homo sapiens	98-103
35128402-0	2022	Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomised, parallel-group pilot clinical study.	beta-Glucans	113-124	synuclein alpha	Homo sapiens	39-54
35128402-3	2022	We have evaluated the Childhood Autism Rating Scale (CARS) and alpha-synuclein levels in this parallel-group, multiple-arm pilot clinical study after supplementation with a biological response modifier beta-glucan food supplement (Nichi Glucan).	beta-Glucans	202-213	synuclein alpha	Homo sapiens	63-78
34995333-0	2022	Control of beta-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence.	beta-Glucans	11-22	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	58-62
34995333-4	2022	Dectin-1 is a major C-type lectin receptor that recognizes beta-glucan in the fungal cell wall.	beta-Glucans	59-70	C-type lectin domain family 7, member a	Mus musculus	0-8
34995333-7	2022	Here we show that the endo-1,3-glucanase Eng1 is differentially expressed in yeast, and together with Yeast Wall Protein 1 (Ywp1), regulates beta-glucan exposure and Dectin-1-dependent immune activation of macrophage by yeast cells.	beta-Glucans	141-152	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	41-45
34995333-10	2022	ENG1 expression and Eng1-mediated beta-glucan trimming are also regulated by antifungal drugs, lactate and N-acetylglucosamine.	beta-Glucans	34-45	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	20-24
34995333-13	2022	Thus, Eng1-regulated beta-glucan exposure in yeast cells modulates the balance between immune protection and immunopathogenesis during disseminated candidiasis.	beta-Glucans	21-32	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	6-10
3040332-1	1987	The binding of the iC3b receptor (CR3) to unopsonized zymosan was shown to result from CR3 attachment to cell wall beta-glucans.	beta-Glucans	115-127	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	34-37
3040332-7	1987	First, neutrophil ingestion of either yeast or yeast-derived beta-glucan particles was blocked by monoclonal anti-CR3, fluid-phase iC3b, or soluble beta-glucan from barley.	beta-Glucans	61-72	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	114-117
3040332-8	1987	Monocyte ingestion of beta-glucan particles was also blocked by anti-CR3, but not by anti-CR1 or anti-C3.	beta-Glucans	22-33	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	69-72
3040332-9	1987	Second, the neutrophil superoxide burst response to either zymosan or beta-glucan particles was blocked by anti-CR3 or fluid-phase iC3b, and was completely absent with neutrophils from 3 patients with an inherited deficiency of CR3.	beta-Glucans	70-81	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	112-115
3040332-9	1987	Second, the neutrophil superoxide burst response to either zymosan or beta-glucan particles was blocked by anti-CR3 or fluid-phase iC3b, and was completely absent with neutrophils from 3 patients with an inherited deficiency of CR3.	beta-Glucans	70-81	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	228-231
3040332-10	1987	Third, CR3 was isolated from solubilized neutrophils by affinity chromatography on beta-glucan-Sepharose.	beta-Glucans	83-94	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	7-10
3040333-1	1987	Previous studies have suggested that neutrophil complement receptor type three (CR3) has two binding sites: (1) a site for fixed iC3b that does not trigger ingestion or a superoxide (O2-) burst, and (2) a function-triggering site for the beta-glucan component of yeast (Saccharomyces cerevisiae) cell walls.	beta-Glucans	238-249	integrin alpha M	Mus musculus	80-83
3040333-10	1987	Thus, fixed C3b or iC3b on Y mediate avid binding of Y to neutrophils via CR1 or the iC3b-binding site of CR3, respectively, but ingestion and an O2- burst response are only triggered when glucans in the Y cell wall secondarily bind to neutrophils via the beta-glucan binding site of CR3.	beta-Glucans	256-267	integrin alpha M	Mus musculus	106-109
2579146-6	1985	Enzymatic hydrolysis of beta-glucan and alpha-mannan with beta-glucosidase or beta-glucanase before their incubation with monocytes abrogated their inhibitory capacity, whereas hydrolysis with alpha-mannosidase or alpha-glucosidase did not.	beta-Glucans	24-35	sucrase-isomaltase	Homo sapiens	214-231
2986134-7	1985	That both phagocytosis and leukotriene generation are inhibited by soluble beta-glucan but not by mannan at a rate compatible with the phagocytic process of monocyte monolayers indicates ligand specificity for a beta-glucan receptor.	beta-Glucans	75-86	C-type lectin domain containing 7A	Homo sapiens	212-232
33978739-6	2021	Our results provide new knowledge on unique glycan-binding specificities for the immune-receptor Dectin-1 towards beta-glucans and the interaction of rotavirus P[19] adhesive protein with mucin O-glycan cores.	beta-Glucans	114-126	C-type lectin domain containing 7A	Homo sapiens	97-105
34010642-4	2021	beta-glucan reduces the effective 2D affinity of FcgammaRIIA for IgG via Lyn and SHP-1 and, in vivo, inhibits FcgammaRIIA-mediated neutrophil recruitment to intravascular IgG deposited in the kidney glomeruli in a glycosphingolipid- and Lyn-dependent manner.	beta-Glucans	0-11	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
34010642-4	2021	beta-glucan reduces the effective 2D affinity of FcgammaRIIA for IgG via Lyn and SHP-1 and, in vivo, inhibits FcgammaRIIA-mediated neutrophil recruitment to intravascular IgG deposited in the kidney glomeruli in a glycosphingolipid- and Lyn-dependent manner.	beta-Glucans	0-11	nuclear receptor subfamily 0 group B member 2	Homo sapiens	81-86
34010642-4	2021	beta-glucan reduces the effective 2D affinity of FcgammaRIIA for IgG via Lyn and SHP-1 and, in vivo, inhibits FcgammaRIIA-mediated neutrophil recruitment to intravascular IgG deposited in the kidney glomeruli in a glycosphingolipid- and Lyn-dependent manner.	beta-Glucans	0-11	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	237-240
34010642-6	2021	In summary, we have identified a pathway for modulating the 2D affinity of FcgammaRIIA for ligand that relies on LacCer-Lyn-SHP-1-mediated inhibitory signaling triggered by beta-glucan, a previously described activator of innate immunity.	beta-Glucans	173-184	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
34010642-6	2021	In summary, we have identified a pathway for modulating the 2D affinity of FcgammaRIIA for ligand that relies on LacCer-Lyn-SHP-1-mediated inhibitory signaling triggered by beta-glucan, a previously described activator of innate immunity.	beta-Glucans	173-184	nuclear receptor subfamily 0 group B member 2	Homo sapiens	124-129
33986196-0	2021	miR-9-5p regulates immunometabolic and epigenetic pathways in beta-glucan-trained immunity via IDH3alpha.	beta-Glucans	62-73	microRNA 95	Homo sapiens	0-8
33986196-0	2021	miR-9-5p regulates immunometabolic and epigenetic pathways in beta-glucan-trained immunity via IDH3alpha.	beta-Glucans	62-73	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	Homo sapiens	95-104
33986196-3	2021	We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation.	beta-Glucans	14-25	microRNA 95	Homo sapiens	34-42
33986196-3	2021	We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation.	beta-Glucans	14-25	interleukin 1 alpha	Homo sapiens	73-81
33986196-3	2021	We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation.	beta-Glucans	14-25	interleukin 6	Homo sapiens	83-87
33986196-3	2021	We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation.	beta-Glucans	14-25	tumor necrosis factor	Homo sapiens	93-102
33986196-7	2021	beta-Glucan-trained monocytes exhibited low IDH3alpha levels, and IDH3alpha overexpression blocked the induction of trained immunity by monocytes.	beta-Glucans	0-11	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	Homo sapiens	44-53
33910729-6	2021	Activation of the human beta-glucan receptor dectin-1 correlated with the amount of beta-glucan in each fraction.	beta-Glucans	24-35	C-type lectin domain containing 7A	Homo sapiens	45-53
33305824-2	2021	Dectin-1 is a lectin receptor of beta-glucan and is specifically expressed in osteoclast precursor cells.	beta-Glucans	33-44	C-type lectin domain family 7, member a	Mus musculus	0-8
33305824-3	2021	In this study, we evaluated the bioactivity of beta-glucan on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and observed that glucan from baker"s yeast inhibited this process in mouse bone marrow cells and dectin-1-overexpressing RAW264.7 (d-RAW) cells.	beta-Glucans	47-58	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	115-120
33305824-3	2021	In this study, we evaluated the bioactivity of beta-glucan on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and observed that glucan from baker"s yeast inhibited this process in mouse bone marrow cells and dectin-1-overexpressing RAW264.7 (d-RAW) cells.	beta-Glucans	47-58	C-type lectin domain family 7, member a	Mus musculus	247-255
33727110-10	2021	Furthermore, mucosal wound healing studies showed that the treatment of IEC-6 with a beta-glucan concentration of 200 mug/mL promoted cell migration and proliferation, and it enhanced the protein expression of cell division control protein 42, Rac-1, RhoA, and Par-3.	beta-Glucans	85-96	Rac family small GTPase 1	Rattus norvegicus	244-249
33727110-10	2021	Furthermore, mucosal wound healing studies showed that the treatment of IEC-6 with a beta-glucan concentration of 200 mug/mL promoted cell migration and proliferation, and it enhanced the protein expression of cell division control protein 42, Rac-1, RhoA, and Par-3.	beta-Glucans	85-96	ras homolog family member A	Rattus norvegicus	251-255
33727110-10	2021	Furthermore, mucosal wound healing studies showed that the treatment of IEC-6 with a beta-glucan concentration of 200 mug/mL promoted cell migration and proliferation, and it enhanced the protein expression of cell division control protein 42, Rac-1, RhoA, and Par-3.	beta-Glucans	85-96	par-3 family cell polarity regulator	Rattus norvegicus	261-266
32250189-5	2021	for activation of desired inflammatory response using non-agonistic beta-glucan particles; a well-known ligand for Dectin-1 receptors.	beta-Glucans	68-79	C-type lectin domain containing 7A	Rattus norvegicus	115-123
34022361-0	2021	Gene expression profile and long noncoding RNA analysis in Candida albicans insoluble beta-glucan-stimulated CD14+ monocytes and THP-1 cells.	beta-Glucans	86-97	CD14 molecule	Homo sapiens	109-113
34022361-3	2021	Our study aimed to investigate and characterize the mRNA and lncRNA transcriptomes of CD14+ monocytes and THP-1 cells stimulated with insoluble beta-glucan by RNA-seq.	beta-Glucans	144-155	CD14 molecule	Homo sapiens	86-90
33877384-4	2021	Furthermore, antitumor effects of SV were also mediated by innate myeloid cell function, which requires both TLR and beta-glucan signaling in a MyD88/TRIF and Dectin-1-dependent manner, respectively.	beta-Glucans	117-128	MYD88 innate immune signal transduction adaptor	Homo sapiens	144-149
33946381-3	2021	Analysis of dectin-1 knockout mice has clarified the downstream signaling pathways and adaptive effector responses triggered by beta-glucan in anti-fungal immunity.	beta-Glucans	128-139	C-type lectin domain family 7, member a	Mus musculus	12-20
33946381-4	2021	On the other hand, assessment of CR3-deficient mice has elucidated the compelling action of beta-glucans in neutrophil-mediated fungal clearance, and the investigation of EphA2-deficient mice has highlighted its novel involvement in host sensing and defense to oral mucosal fungal infection.	beta-Glucans	92-104	integrin alpha M	Mus musculus	33-36
33880723-0	2021	beta-Glucan from Saccharomyces cerevisiae alleviates oxidative stress in LPS-stimulated RAW264.7 cells via Dectin-1/Nrf2/HO-1 signaling pathway.	beta-Glucans	0-11	C-type lectin domain family 7, member a	Mus musculus	107-115
33880723-0	2021	beta-Glucan from Saccharomyces cerevisiae alleviates oxidative stress in LPS-stimulated RAW264.7 cells via Dectin-1/Nrf2/HO-1 signaling pathway.	beta-Glucans	0-11	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
33880723-0	2021	beta-Glucan from Saccharomyces cerevisiae alleviates oxidative stress in LPS-stimulated RAW264.7 cells via Dectin-1/Nrf2/HO-1 signaling pathway.	beta-Glucans	0-11	heme oxygenase 1	Mus musculus	121-125
33880723-2	2021	The objectives of this research were to determine whether the beta-glucan from Saccharomyces cerevisiae could regulate oxidative stress through the Dectin-1/Nrf2/HO-1 signaling pathway in lipopolysaccharides (LPS)-stimulated RAW264.7 cells.	beta-Glucans	62-73	C-type lectin domain family 7, member a	Mus musculus	148-156
33880723-2	2021	The objectives of this research were to determine whether the beta-glucan from Saccharomyces cerevisiae could regulate oxidative stress through the Dectin-1/Nrf2/HO-1 signaling pathway in lipopolysaccharides (LPS)-stimulated RAW264.7 cells.	beta-Glucans	62-73	nuclear factor, erythroid derived 2, like 2	Mus musculus	157-161
33880723-2	2021	The objectives of this research were to determine whether the beta-glucan from Saccharomyces cerevisiae could regulate oxidative stress through the Dectin-1/Nrf2/HO-1 signaling pathway in lipopolysaccharides (LPS)-stimulated RAW264.7 cells.	beta-Glucans	62-73	heme oxygenase 1	Mus musculus	162-166
33880723-3	2021	In this study, we examined the effects of beta-glucan on the enzyme activity or production of oxidative stress indicators in LPS-stimulated RAW264.7 cells by biochemical analysis and the protein expression of key factors of Dectin-1/Nrf2/HO-1 signaling pathway by immunofluorescence and western blot.	beta-Glucans	42-53	C-type lectin domain family 7, member a	Mus musculus	224-232
33880723-4	2021	The biochemical analysis results showed that beta-glucan increased the LPS-induced downregulation of enzyme activity of intracellular heme oxygenase (HO), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) while decreasing the production of reactive oxygen species (ROS) and malondialdehyde (MDA).	beta-Glucans	45-56	catalase	Mus musculus	183-191
33880723-4	2021	The biochemical analysis results showed that beta-glucan increased the LPS-induced downregulation of enzyme activity of intracellular heme oxygenase (HO), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) while decreasing the production of reactive oxygen species (ROS) and malondialdehyde (MDA).	beta-Glucans	45-56	catalase	Mus musculus	193-196
33880723-5	2021	Furthermore, immunofluorescence results showed that beta-glucan can activate the nuclear factor erythroid 2-related factor 2 (Nrf2).	beta-Glucans	52-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-124
33880723-5	2021	Furthermore, immunofluorescence results showed that beta-glucan can activate the nuclear factor erythroid 2-related factor 2 (Nrf2).	beta-Glucans	52-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	126-130
33880723-6	2021	The antioxidant mechanism study indicated that beta-glucan activated dendritic-cell-associated C-type lectin 1 (Dectin-1) receptors mediated Nrf2/HO-1 signaling pathway, thereby downregulating the production of ROS and thus produced the antioxidant effects in LPS-stimulated RAW 264.7 cells.	beta-Glucans	47-58	C-type lectin domain family 7, member a	Mus musculus	112-120
33880723-6	2021	The antioxidant mechanism study indicated that beta-glucan activated dendritic-cell-associated C-type lectin 1 (Dectin-1) receptors mediated Nrf2/HO-1 signaling pathway, thereby downregulating the production of ROS and thus produced the antioxidant effects in LPS-stimulated RAW 264.7 cells.	beta-Glucans	47-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
33880723-6	2021	The antioxidant mechanism study indicated that beta-glucan activated dendritic-cell-associated C-type lectin 1 (Dectin-1) receptors mediated Nrf2/HO-1 signaling pathway, thereby downregulating the production of ROS and thus produced the antioxidant effects in LPS-stimulated RAW 264.7 cells.	beta-Glucans	47-58	heme oxygenase 1	Mus musculus	146-150
33880723-7	2021	In conclusion, these results indicate that beta-glucan potently alleviated oxidative stress via Dectin-1/Nrf2/HO-1 in LPS-stimulated RAW 264.7 cells.	beta-Glucans	43-54	C-type lectin domain family 7, member a	Mus musculus	96-104
33880723-7	2021	In conclusion, these results indicate that beta-glucan potently alleviated oxidative stress via Dectin-1/Nrf2/HO-1 in LPS-stimulated RAW 264.7 cells.	beta-Glucans	43-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-109
33880723-7	2021	In conclusion, these results indicate that beta-glucan potently alleviated oxidative stress via Dectin-1/Nrf2/HO-1 in LPS-stimulated RAW 264.7 cells.	beta-Glucans	43-54	heme oxygenase 1	Mus musculus	110-114
33175182-9	2021	Significantly, beta-glucan worked synergistically with IFN-gamma to reverse the risk signature by repolarizing the MPE-Mphi toward the M1 pattern, enhancing anti-cancer activity.	beta-Glucans	15-26	interferon gamma	Homo sapiens	55-64
33477077-0	2021	Ameliorating Effects of beta-glucan on Epigastric Artery Island Flap Ischemia-Reperfusion Injury.	beta-Glucans	24-35	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	64-68
33477077-4	2021	In this study, we present the ameliorating effects of beta-glucan on ischemia-reperfusion injury using the epigastric artery island-flap in rats.	beta-Glucans	54-65	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	132-136
33477077-14	2021	RESULTS: Topographic flap survival was significantly better in the beta-glucan administered group.	beta-Glucans	67-78	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	21-25
33877384-4	2021	Furthermore, antitumor effects of SV were also mediated by innate myeloid cell function, which requires both TLR and beta-glucan signaling in a MyD88/TRIF and Dectin-1-dependent manner, respectively.	beta-Glucans	117-128	TIR domain containing adaptor molecule 1	Homo sapiens	150-154
33616974-2	2021	We previously reported that beta-glucans, major fungal cell-wall glycans, induced chemokine secretion by IEC lines in a Dectin-1- and Syk-dependent manner.	beta-Glucans	28-40	C-type lectin domain containing 7A	Homo sapiens	120-128
33616974-2	2021	We previously reported that beta-glucans, major fungal cell-wall glycans, induced chemokine secretion by IEC lines in a Dectin-1- and Syk-dependent manner.	beta-Glucans	28-40	spleen associated tyrosine kinase	Homo sapiens	134-137
33616974-4	2021	Commensal fungi and beta-glucans activated Syk and ERK in IEC lines.	beta-Glucans	20-32	spleen associated tyrosine kinase	Homo sapiens	43-46
33616974-5	2021	However, only beta-glucans activated p38, JNK, and the transcription factors NF-kappaB p65 and c-JUN, which were necessary for cytokine secretion.	beta-Glucans	14-26	mitogen-activated protein kinase 14	Homo sapiens	37-40
33616974-5	2021	However, only beta-glucans activated p38, JNK, and the transcription factors NF-kappaB p65 and c-JUN, which were necessary for cytokine secretion.	beta-Glucans	14-26	mitogen-activated protein kinase 8	Homo sapiens	42-45
33616974-5	2021	However, only beta-glucans activated p38, JNK, and the transcription factors NF-kappaB p65 and c-JUN, which were necessary for cytokine secretion.	beta-Glucans	14-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	77-90
33616974-5	2021	However, only beta-glucans activated p38, JNK, and the transcription factors NF-kappaB p65 and c-JUN, which were necessary for cytokine secretion.	beta-Glucans	14-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
33936850-4	2021	beta-Glucan was demonstrated to synergistically enhance the VS-stimulated immune response, including the production of interleukin-6, tumor necrosis factor-alpha, and nitric oxide, mainly through the mitogen-activated protein kinase pathway in macrophages.	beta-Glucans	0-11	interleukin 6	Homo sapiens	119-132
33685996-3	2021	In this article, we show that the tyrosine kinase receptor EPH receptor B2 (EPHB2), together with dectin-1, recognizes beta-glucan and activates downstream signaling pathways.	beta-Glucans	119-130	EPH receptor B2	Homo sapiens	59-74
33685996-3	2021	In this article, we show that the tyrosine kinase receptor EPH receptor B2 (EPHB2), together with dectin-1, recognizes beta-glucan and activates downstream signaling pathways.	beta-Glucans	119-130	EPH receptor B2	Homo sapiens	76-81
33685996-3	2021	In this article, we show that the tyrosine kinase receptor EPH receptor B2 (EPHB2), together with dectin-1, recognizes beta-glucan and activates downstream signaling pathways.	beta-Glucans	119-130	C-type lectin domain containing 7A	Homo sapiens	98-106
33936850-4	2021	beta-Glucan was demonstrated to synergistically enhance the VS-stimulated immune response, including the production of interleukin-6, tumor necrosis factor-alpha, and nitric oxide, mainly through the mitogen-activated protein kinase pathway in macrophages.	beta-Glucans	0-11	tumor necrosis factor	Homo sapiens	134-161
33689587-5	2021	B-cell stimulation by CpG and beta-glucan via PRR resulted in activation of mTOR-dependent and independent pathways.	beta-Glucans	30-41	mechanistic target of rapamycin kinase	Homo sapiens	76-80
33557290-1	2021	beta-Glucan is widely distributed in various plants and microorganisms and is composed of beta-1,3-linked d-glucose units.	beta-Glucans	0-11	immunoglobulin kappa variable 2D-30	Homo sapiens	90-96
33428957-2	2021	Dectin-1 is a cell-surface immune receptor, which plays an important role in immunological defense against fungal pathogens and beta-glucan-mediated immune modulation.	beta-Glucans	128-139	C-type lectin domain containing 7A	Homo sapiens	0-8
33428957-8	2021	In summary, our work provided insights into lentinan"s advanced structure and beta-glucan recognition by dectin-1.	beta-Glucans	78-89	C-type lectin domain containing 7A	Homo sapiens	105-113
33679785-0	2021	beta-Glucan-Induced IL-10 Secretion by Monocytes Triggers Porcine NK Cell Cytotoxicity.	beta-Glucans	0-11	interleukin 10	Homo sapiens	20-25
33679785-8	2021	This effect depended on factors secreted by CD14+ monocytes upon beta-glucan priming.	beta-Glucans	65-76	CD14 molecule	Homo sapiens	44-48
33679785-9	2021	Further analysis showed that monocytes secrete TNF-alpha, IL-6, and IL-10 upon beta-glucan addition.	beta-Glucans	79-90	tumor necrosis factor	Homo sapiens	47-56
33679785-9	2021	Further analysis showed that monocytes secrete TNF-alpha, IL-6, and IL-10 upon beta-glucan addition.	beta-Glucans	79-90	interleukin 6	Homo sapiens	58-62
33679785-9	2021	Further analysis showed that monocytes secrete TNF-alpha, IL-6, and IL-10 upon beta-glucan addition.	beta-Glucans	79-90	interleukin 10	Homo sapiens	68-73
33679785-10	2021	Of these, IL-10 turned out to play a critical role in beta-glucan-triggered NK cell cytotoxicity, since depletion of IL-10 completely abrogated the beta-glucan-induced increase in cytotoxicity.	beta-Glucans	54-65	interleukin 10	Homo sapiens	10-15
33679785-10	2021	Of these, IL-10 turned out to play a critical role in beta-glucan-triggered NK cell cytotoxicity, since depletion of IL-10 completely abrogated the beta-glucan-induced increase in cytotoxicity.	beta-Glucans	54-65	interleukin 10	Homo sapiens	117-122
33679785-10	2021	Of these, IL-10 turned out to play a critical role in beta-glucan-triggered NK cell cytotoxicity, since depletion of IL-10 completely abrogated the beta-glucan-induced increase in cytotoxicity.	beta-Glucans	148-159	interleukin 10	Homo sapiens	10-15
33679785-10	2021	Of these, IL-10 turned out to play a critical role in beta-glucan-triggered NK cell cytotoxicity, since depletion of IL-10 completely abrogated the beta-glucan-induced increase in cytotoxicity.	beta-Glucans	148-159	interleukin 10	Homo sapiens	117-122
33679785-12	2021	In conclusion, we show that beta-glucans trigger IL-10 secretion by porcine monocytes, which in turn leads to increased NK cell cytotoxicity, and thereby identify IL-10 as a potent stimulus of porcine NK cell cytotoxicity.	beta-Glucans	28-40	interleukin 10	Homo sapiens	49-54
33679785-12	2021	In conclusion, we show that beta-glucans trigger IL-10 secretion by porcine monocytes, which in turn leads to increased NK cell cytotoxicity, and thereby identify IL-10 as a potent stimulus of porcine NK cell cytotoxicity.	beta-Glucans	28-40	interleukin 10	Homo sapiens	163-168
33550415-5	2021	Here, we sought to evaluate if Zymosan, a beta-glucan-containing ligand of the PRRs Dectin-1/TLR-2, would enhance phagocyte function and the immune response of mice challenged with P. brasiliensis.	beta-Glucans	42-53	C-type lectin domain family 7, member a	Mus musculus	84-92
33550415-5	2021	Here, we sought to evaluate if Zymosan, a beta-glucan-containing ligand of the PRRs Dectin-1/TLR-2, would enhance phagocyte function and the immune response of mice challenged with P. brasiliensis.	beta-Glucans	42-53	toll-like receptor 2	Mus musculus	93-98
33561965-0	2021	High beta-Glucan Barley Supplementation Improves Glucose Tolerance by Increasing GLP-1 Secretion in Diet-Induced Obesity Mice.	beta-Glucans	5-16	glucagon	Mus musculus	81-86
33677586-12	2021	Our data show that yeast beta-glucan ingestion prevented oxidative stress, pro-inflammatory markers synthesis, and prevented eNOS reduction induced by periodontal disease in middle-aged rats.	beta-Glucans	25-36	nitric oxide synthase 3	Rattus norvegicus	125-129
33620105-5	2021	In healthy subjects, the IL1F10 associated single nucleotide polymorphism rs58965312 correlated with higher plasma IL-38 concentrations and reduced induction of trained immunity by beta-glucan ex vivo.	beta-Glucans	181-192	interleukin 1 family, member 10	Mus musculus	25-31
33608654-0	2021	The effect of oat beta-glucan on postprandial blood glucose and insulin responses: a systematic review and meta-analysis.	beta-Glucans	18-29	insulin	Homo sapiens	64-71
33557290-4	2021	To understand the structure-function relationship of beta-glucan, we constructed a split-luciferase complementation assay for the structural analysis of long-chain beta-1,6-branched beta-1,3-glucan.	beta-Glucans	53-64	immunoglobulin kappa variable 2D-30	Homo sapiens	182-188
33557290-7	2021	To test the applicability of this assay, beta-glucan and two beta-glucan recognition proteins were mixed, resulting in an increase in the luminescence intensity in a beta-1,3-glucan with a long polymer of beta-1,6-glucan in a dose-dependent manner.	beta-Glucans	41-52	immunoglobulin kappa variable 2D-30	Homo sapiens	166-172
33557290-7	2021	To test the applicability of this assay, beta-glucan and two beta-glucan recognition proteins were mixed, resulting in an increase in the luminescence intensity in a beta-1,3-glucan with a long polymer of beta-1,6-glucan in a dose-dependent manner.	beta-Glucans	41-52	immunoglobulin kappa variable 2D-30	Homo sapiens	205-211
33557290-7	2021	To test the applicability of this assay, beta-glucan and two beta-glucan recognition proteins were mixed, resulting in an increase in the luminescence intensity in a beta-1,3-glucan with a long polymer of beta-1,6-glucan in a dose-dependent manner.	beta-Glucans	61-72	immunoglobulin kappa variable 2D-30	Homo sapiens	166-172
33557290-7	2021	To test the applicability of this assay, beta-glucan and two beta-glucan recognition proteins were mixed, resulting in an increase in the luminescence intensity in a beta-1,3-glucan with a long polymer of beta-1,6-glucan in a dose-dependent manner.	beta-Glucans	61-72	immunoglobulin kappa variable 2D-30	Homo sapiens	205-211
33557290-8	2021	This simple test also allows the monitoring of real-time changes in the side chain structure and serves as a convenient method to distinguish between beta-1,3-glucan and long-chain beta-1,6-branched beta-1,3-glucan in various soluble and insoluble beta-glucans.	beta-Glucans	248-260	immunoglobulin kappa variable 2D-30	Homo sapiens	150-156
33326254-13	2021	Serum anti-GD2 (immunoglobulin G1 [IgG1] and IgM) and anti-GD3 (IgG1) titers showed notable increases following the initiation of beta-glucan at week 6.	beta-Glucans	130-141	GRDX	Homo sapiens	59-62
33278951-2	2021	In this study, we investigated the biological effect of beta-glucan from Schizophyllum commune, called Schizophyllan (SPG) on Interleukin-10 (IL-10) expression induced by a lipopolysaccharide (LPS) from Aggregatibacter actinomycetemcomitans in murine macrophages (J774.1).	beta-Glucans	56-67	interleukin 10	Mus musculus	142-147
32385687-0	2021	Enrichment of bread with beta-glucans or resistant starch induces similar glucose, insulin and appetite hormone responses in healthy adults.	beta-Glucans	25-37	insulin	Homo sapiens	83-90
32385687-1	2021	PURPOSE: beta-Glucans (betaG) and resistant starch (RS) are known for their effects on the improvement of glucose tolerance and enhancement of insulin sensitivity.	beta-Glucans	9-21	insulin	Homo sapiens	143-150
32385687-1	2021	PURPOSE: beta-Glucans (betaG) and resistant starch (RS) are known for their effects on the improvement of glucose tolerance and enhancement of insulin sensitivity.	beta-Glucans	23-28	insulin	Homo sapiens	143-150
33499397-6	2021	Beta-glucan supplementation caused an increase in the expression of TLR 5 and Dectin-1 with no changes in the expression of Caspase-3 and LC3B.	beta-Glucans	0-11	toll-like receptor 5	Rattus norvegicus	68-73
33499397-6	2021	Beta-glucan supplementation caused an increase in the expression of TLR 5 and Dectin-1 with no changes in the expression of Caspase-3 and LC3B.	beta-Glucans	0-11	C-type lectin domain containing 7A	Rattus norvegicus	78-86
33339585-0	2021	Binding assay of human Dectin-1 variants to DNA/beta-glucan complex for active-targeting delivery of antisense DNA.	beta-Glucans	48-59	C-type lectin domain containing 7A	Homo sapiens	23-31
33339585-1	2021	The lectin Dectin-1 is a good target for beta-glucan-mediated drug delivery.	beta-Glucans	41-52	C-type lectin domain containing 7A	Homo sapiens	11-19
33339585-4	2021	When we transfected the Dectin-1 gene into a non-Dectin-1-expressing cell line and examined cellular uptake of the antisense DNA/beta-glucan complex, we confirmed that expression of the target gene was effectively suppressed through beta-glucan/Dectin-1-mediated uptake.	beta-Glucans	129-140	C-type lectin domain family 7, member a	Mus musculus	24-32
33339585-4	2021	When we transfected the Dectin-1 gene into a non-Dectin-1-expressing cell line and examined cellular uptake of the antisense DNA/beta-glucan complex, we confirmed that expression of the target gene was effectively suppressed through beta-glucan/Dectin-1-mediated uptake.	beta-Glucans	233-244	C-type lectin domain family 7, member a	Mus musculus	24-32
33339585-5	2021	The present results suggest that the beta-glucan complex would be an effective tool to deliver antisense oligonucleotide (AS-ODN) to Dectin-1-expressing cells not only for mice but also for humans.	beta-Glucans	37-48	C-type lectin domain family 7, member a	Mus musculus	133-141
32748397-3	2020	The binding affinity of barley beta-glucan and zymosan with Dectin-1 and TLR2 were studied in silico.	beta-Glucans	31-42	C-type lectin domain family 7, member a	Mus musculus	60-68
32511980-2	2021	The CLRs Dectin-1 and Dectin-2, which are triggered by beta-glucan and alpha-mannan, respectively, contribute to up-regulation of the inflammatory response.	beta-Glucans	55-66	C-type lectin domain family 7, member a	Mus musculus	9-17
32511980-2	2021	The CLRs Dectin-1 and Dectin-2, which are triggered by beta-glucan and alpha-mannan, respectively, contribute to up-regulation of the inflammatory response.	beta-Glucans	55-66	C-type lectin domain family 4, member n	Mus musculus	22-30
33245358-0	2020	beta-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1alpha axis.	beta-Glucans	0-11	nuclear receptor subfamily 4 group A member 1	Homo sapiens	76-81
33245358-0	2020	beta-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1alpha axis.	beta-Glucans	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
33046489-3	2020	Thus, we explored the therapeutic potential of the lymphocyte class I scavenger receptor CD5, a non-redundant component of the antifungal host immune response that binds to fungal beta-glucans.Methods: antifungal properties of the soluble ectodomain of human CD5 (shCD5) were assessed in vivo in experimental models of systemic fungal infection induced by pathogenic species (Candida albicans and Cryptococcus neoformans).	beta-Glucans	180-192	CD5 molecule	Homo sapiens	89-92
32748397-0	2020	Barley beta-Glucan and zymosan induce Dectin-1 and Toll-like receptor2 co-localization and anti-leishmanial immune response in Leishmania donovani infected BALB/c mice.	beta-Glucans	7-18	C-type lectin domain family 7, member a	Mus musculus	38-46
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	epidermal growth factor receptor	Homo sapiens	119-151
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	AKT serine/threonine kinase 1	Homo sapiens	152-155
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	mitogen-activated protein kinase 1	Homo sapiens	156-197
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	forkhead box A2	Homo sapiens	248-253
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	mucin-5B	Canis lupus familiaris	286-292
33069717-8	2021	Mechanistic studies reveal that B. dermatitidis infection, as well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extracellular signal-regulated kinase 1/2 signaling pathway that inhibits the expression of FOXA2, resulting in overexpression of MUC5AC and MUC5B in canine airway cells.	beta-Glucans	70-81	mucin 5B, oligomeric mucus/gel-forming	Canis lupus familiaris	297-302
33613105-10	2021	Furthermore, in macrophage cell lines and primary bone marrow- derived macrophages (BMDMs), beta-glucan-induced trained immunity can increase ROS production by activating NOX2 to promote macrophage LAP.	beta-Glucans	92-103	cytochrome b-245, beta polypeptide	Mus musculus	171-175
32748397-3	2020	The binding affinity of barley beta-glucan and zymosan with Dectin-1 and TLR2 were studied in silico.	beta-Glucans	31-42	toll-like receptor 2	Mus musculus	73-77
32748397-10	2020	These results establish a novel modus operandi of beta-glucans through Dectin-1 and TLR2 and suggest an immuno-modulatory potential against infectious diseases.	beta-Glucans	50-62	C-type lectin domain family 7, member a	Mus musculus	71-79
32748397-10	2020	These results establish a novel modus operandi of beta-glucans through Dectin-1 and TLR2 and suggest an immuno-modulatory potential against infectious diseases.	beta-Glucans	50-62	toll-like receptor 2	Mus musculus	84-88
33008466-6	2020	In the hippocampus, beta-glucan countered the HFFD-induced microglia activation and its engulfment of synaptic puncta, and upregulation of proinflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) mRNA expression.	beta-Glucans	20-31	tumor necrosis factor	Mus musculus	165-174
33364534-8	2020	Meanwhile, 4 mg/L of BG gave negative cytotoxic effects on normal gingival cell line (hGF) but induced antiproliferation (IC50 = 0.23 mg/mL) against cancerous oral Asian cellosaurus cell line (ORL-48).	beta-Glucans	21-23	hepatocyte growth factor	Homo sapiens	86-89
33123097-1	2020	Dectin-1 and ephrin type-A receptor 2 (EphA2) receptors recognize beta-glucan present in the fungal cell wall.	beta-Glucans	66-77	C-type lectin domain containing 7A	Homo sapiens	0-8
33008466-6	2020	In the hippocampus, beta-glucan countered the HFFD-induced microglia activation and its engulfment of synaptic puncta, and upregulation of proinflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) mRNA expression.	beta-Glucans	20-31	interleukin 1 alpha	Mus musculus	176-184
33008466-6	2020	In the hippocampus, beta-glucan countered the HFFD-induced microglia activation and its engulfment of synaptic puncta, and upregulation of proinflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) mRNA expression.	beta-Glucans	20-31	interleukin 6	Mus musculus	190-194
33008466-7	2020	Also, in the hippocampus, beta-glucan significantly promoted PTP1B-IRS-pAKT-pGSK3beta-pTau signaling for synaptogenesis, improved the synaptic ultrastructure examined by transmission electron microscopy, and increased both pre- and postsynaptic protein levels compared to the HFFD-treated group.	beta-Glucans	26-37	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	61-66
33008466-7	2020	Also, in the hippocampus, beta-glucan significantly promoted PTP1B-IRS-pAKT-pGSK3beta-pTau signaling for synaptogenesis, improved the synaptic ultrastructure examined by transmission electron microscopy, and increased both pre- and postsynaptic protein levels compared to the HFFD-treated group.	beta-Glucans	26-37	isoleucine-tRNA synthetase	Mus musculus	67-70
33008466-8	2020	In the colon, beta-glucan reversed HFFD-induced gut barrier dysfunction increased the thickness of colonic mucus (Alcian blue and mucin-2 glycoprotein immunofluorescence staining), increased the levels of tight junction proteins occludin and zonula occludens-1, and attenuated bacterial endotoxin translocation.	beta-Glucans	14-25	mucin 2	Mus musculus	130-137
33008466-8	2020	In the colon, beta-glucan reversed HFFD-induced gut barrier dysfunction increased the thickness of colonic mucus (Alcian blue and mucin-2 glycoprotein immunofluorescence staining), increased the levels of tight junction proteins occludin and zonula occludens-1, and attenuated bacterial endotoxin translocation.	beta-Glucans	14-25	occludin	Mus musculus	229-237
33177919-0	2020	Novel Antihypertension Mechanism of beta-Glucan by Corin and ANP-Mediated Natriuresis in Mice.	beta-Glucans	36-47	corin, serine peptidase	Mus musculus	51-56
32953945-1	2020	Introduction: Recognition of fungal surface beta-glucan by pattern recognition receptor Dectin-1 is a critical process for fungal clearance in the lung.	beta-Glucans	44-55	C-type lectin domain family 7, member a	Mus musculus	88-96
32953945-15	2020	The functional significance of GSNO treatment of macrophages is shown by reduced beta-glucan-mediated signaling in terms of NF-kappaB function and IL-6 expression.	beta-Glucans	81-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
32953945-15	2020	The functional significance of GSNO treatment of macrophages is shown by reduced beta-glucan-mediated signaling in terms of NF-kappaB function and IL-6 expression.	beta-Glucans	81-92	interleukin 6	Mus musculus	147-151
32962826-0	2020	Fungal beta-glucans and mannan stimulate peripheral blood mononuclear cells to cytokine production in Syk-dependent manner.	beta-Glucans	7-19	spleen associated tyrosine kinase	Homo sapiens	102-105
32716363-4	2020	We found that NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1beta production were reduced in beta-glucan-reprogrammed macrophages.	beta-Glucans	114-125	interleukin 1 alpha	Homo sapiens	78-86
32716363-5	2020	beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation.	beta-Glucans	0-11	NLR family pyrin domain containing 3	Homo sapiens	34-39
32716363-5	2020	beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation.	beta-Glucans	0-11	PYD and CARD domain containing	Homo sapiens	145-202
32716363-5	2020	beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation.	beta-Glucans	0-11	PYD and CARD domain containing	Homo sapiens	204-207
32716363-6	2020	Importantly, beta-glucan-induced memory in macrophages resulted in a remarkable attenuation of IL-1beta secretion and caspase-1 activation in patients with an NLRP3-associated autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS).	beta-Glucans	13-24	interleukin 1 alpha	Homo sapiens	95-103
32716363-6	2020	Importantly, beta-glucan-induced memory in macrophages resulted in a remarkable attenuation of IL-1beta secretion and caspase-1 activation in patients with an NLRP3-associated autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS).	beta-Glucans	13-24	caspase 1	Homo sapiens	118-127
32716363-6	2020	Importantly, beta-glucan-induced memory in macrophages resulted in a remarkable attenuation of IL-1beta secretion and caspase-1 activation in patients with an NLRP3-associated autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS).	beta-Glucans	13-24	NLR family pyrin domain containing 3	Homo sapiens	159-164
32716363-7	2020	Our findings demonstrate that beta-glucan-induced innate immune memory represses IL-1beta-mediated inflammation and support its potential clinical use in NLRP3-driven diseases.	beta-Glucans	30-41	interleukin 1 alpha	Homo sapiens	81-89
32716363-7	2020	Our findings demonstrate that beta-glucan-induced innate immune memory represses IL-1beta-mediated inflammation and support its potential clinical use in NLRP3-driven diseases.	beta-Glucans	30-41	NLR family pyrin domain containing 3	Homo sapiens	154-159
33012977-6	2020	qPCR and ELISA revealed that the gene and protein expression levels of SBD-1, IL-6, and IL-10 in the OREs significantly increased (P < 0.05) after treatment with beta-glucan compared with controls.	beta-Glucans	162-173	interleukin-10	Ovis aries	88-93
33012977-7	2020	This study identified the feasibility and optimal conditions of ORE culture and demonstrated that beta-glucan activates SBD-1, IL-6, and IL-10 secretion in OREs to promote mucosal immunity.	beta-Glucans	98-109	interleukin-10	Ovis aries	137-142
32716363-0	2020	beta-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies.	beta-Glucans	0-11	NLR family pyrin domain containing 3	Homo sapiens	64-69
32716363-4	2020	We found that NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1beta production were reduced in beta-glucan-reprogrammed macrophages.	beta-Glucans	114-125	NLR family pyrin domain containing 3	Homo sapiens	14-19
32716363-4	2020	We found that NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1beta production were reduced in beta-glucan-reprogrammed macrophages.	beta-Glucans	114-125	caspase 1	Homo sapiens	42-51
33177919-4	2020	Here, we reported a novel antihypertensive mechanism of beta-glucans, involved with corin and ANP in mice.	beta-Glucans	56-68	corin, serine peptidase	Mus musculus	84-89
33177919-5	2020	We showed that multiple oral administrations of beta-glucan induced the expression of corin and ANP, and also increased natriuresis in mice.	beta-Glucans	48-59	corin, serine peptidase	Mus musculus	86-91
33177919-6	2020	Microarray analysis showed that corin gene expression was only upregulated in mice liver by multiple, not single, oral administrations of the beta-glucan fraction of Phellinus baumii (BGF).	beta-Glucans	142-153	corin, serine peptidase	Mus musculus	32-37
33177919-7	2020	Corin was induced in liver and kidney tissues by the beta-glucans from zymosan and barley, as well as by BGF.	beta-Glucans	53-65	corin, serine peptidase	Mus musculus	0-5
33177919-8	2020	In addition to P. baumii, beta-glucans from two other mushrooms, Phellinus linteus and Ganoderma lucidum, also induced corin mRNA expression in mouse liver.	beta-Glucans	26-38	corin, serine peptidase	Mus musculus	119-124
33177919-11	2020	In conclusion, we found that the oral administration of beta-glucans could induce corin expression, ANP production, and sodium excretion in mice.	beta-Glucans	56-68	corin, serine peptidase	Mus musculus	82-87
33177919-12	2020	Our findings will be helpful for investigations of beta-glucans in corin and ANP-related fields, including blood pressure, salt-water balance, and circulation.	beta-Glucans	51-63	corin, serine peptidase	Mus musculus	67-72
33364531-6	2020	In contrast, TNFalpha production induced by och1Delta was increased, relative to wild type, due to increased beta-glucan exposure, when mouse or human macrophages were used.	beta-Glucans	109-120	tumor necrosis factor	Mus musculus	13-21
32793229-15	2020	This study is the first to indicate the role of E2 in the trained immunity induced by beta-glucan to protect against E. coli-induced sepsis via the non-canonical NFkappaB pathway.	beta-Glucans	86-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-170
32170601-4	2020	Primed with oat beta-glucan, the mRNA expression and production of TNF-alpha and IL-6 significantly increased in response to re-stimulation of TLR-4/2 ligands.	beta-Glucans	16-27	tumor necrosis factor	Homo sapiens	67-76
32170601-4	2020	Primed with oat beta-glucan, the mRNA expression and production of TNF-alpha and IL-6 significantly increased in response to re-stimulation of TLR-4/2 ligands.	beta-Glucans	16-27	interleukin 6	Homo sapiens	81-85
32170601-4	2020	Primed with oat beta-glucan, the mRNA expression and production of TNF-alpha and IL-6 significantly increased in response to re-stimulation of TLR-4/2 ligands.	beta-Glucans	16-27	toll like receptor 4	Homo sapiens	143-150
32170601-6	2020	In addition, inhibiting these enzymes decreased the production of TNF-alpha and IL-6 boosted by oat beta-glucan.	beta-Glucans	100-111	tumor necrosis factor	Homo sapiens	66-75
32170601-6	2020	In addition, inhibiting these enzymes decreased the production of TNF-alpha and IL-6 boosted by oat beta-glucan.	beta-Glucans	100-111	interleukin 6	Homo sapiens	80-84
32713066-4	2020	After 8 weeks of beta-glucan treatments, results showed that beta-glucan effectively decreased the serum ALT and AST levels compared with the MCD model.	beta-Glucans	17-28	glutamic pyruvic transaminase, soluble	Mus musculus	105-108
32713066-4	2020	After 8 weeks of beta-glucan treatments, results showed that beta-glucan effectively decreased the serum ALT and AST levels compared with the MCD model.	beta-Glucans	61-72	glutamic pyruvic transaminase, soluble	Mus musculus	105-108
32713066-4	2020	After 8 weeks of beta-glucan treatments, results showed that beta-glucan effectively decreased the serum ALT and AST levels compared with the MCD model.	beta-Glucans	61-72	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	113-116
32713066-6	2020	Furthermore, the ER stress-responsive proteins, including GRP78, p-eiF-2alpha, and p-JNK, were markedly restrained by beta-glucan, while ERp57, p-MAPK, and p-Akt were significantly increased after beta-glucan treatment.	beta-Glucans	118-129	heat shock protein 5	Mus musculus	58-63
32713066-6	2020	Furthermore, the ER stress-responsive proteins, including GRP78, p-eiF-2alpha, and p-JNK, were markedly restrained by beta-glucan, while ERp57, p-MAPK, and p-Akt were significantly increased after beta-glucan treatment.	beta-Glucans	118-129	eukaryotic translation initiation factor 2A	Mus musculus	67-77
32713066-6	2020	Furthermore, the ER stress-responsive proteins, including GRP78, p-eiF-2alpha, and p-JNK, were markedly restrained by beta-glucan, while ERp57, p-MAPK, and p-Akt were significantly increased after beta-glucan treatment.	beta-Glucans	118-129	mitogen-activated protein kinase 8	Mus musculus	85-88
32713066-6	2020	Furthermore, the ER stress-responsive proteins, including GRP78, p-eiF-2alpha, and p-JNK, were markedly restrained by beta-glucan, while ERp57, p-MAPK, and p-Akt were significantly increased after beta-glucan treatment.	beta-Glucans	118-129	thymoma viral proto-oncogene 1	Mus musculus	158-161
32764938-8	2020	Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma).	beta-Glucans	9-20	interleukin 1 alpha	Homo sapiens	99-107
32764938-8	2020	Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma).	beta-Glucans	9-20	interleukin 6	Homo sapiens	109-113
32764938-8	2020	Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma).	beta-Glucans	9-20	tumor necrosis factor	Homo sapiens	115-124
32764938-8	2020	Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma).	beta-Glucans	9-20	interferon gamma	Homo sapiens	126-135
32576672-8	2020	Soluble factors produced following exposure of HSPCs to dectin-1 agonists acted in a paracrine manner to induce myeloid differentiation and to influence the function of macrophages derived from dectin-1-unresponsive or beta-glucan-unexposed HSPCs.	beta-Glucans	219-230	C-type lectin domain family 7, member a	Mus musculus	56-64
32733815-6	2020	In the current study, we demonstrate that dectin-1-mediated recognition of beta-glucan on the cell wall of the clinically relevant fungal pathogen Aspergillus fumigatus promotes the activation of a protective cascade of type I and III interferon expression.	beta-Glucans	75-86	C-type lectin domain family 7, member a	Mus musculus	42-50
32579151-2	2020	Throughout his career, Siamon has focused on macrophages, and his work led to the identification of the pan-macrophage marker F4/80 and the description of a role for Dectin-1 in the innate recognition of beta-glucans.	beta-Glucans	204-216	C-type lectin domain containing 7A	Homo sapiens	166-174
32129526-4	2020	Furthermore, we found that after the treatment of Paeonol, the fungal dysbiosis is improved, and the fungal abundance is reduced, and the translocation of beta-glucan to the liver and its mediated Dectin-1/IL-1beta signaling pathway is blocked.	beta-Glucans	155-166	C-type lectin domain family 7, member a	Mus musculus	197-205
32129526-4	2020	Furthermore, we found that after the treatment of Paeonol, the fungal dysbiosis is improved, and the fungal abundance is reduced, and the translocation of beta-glucan to the liver and its mediated Dectin-1/IL-1beta signaling pathway is blocked.	beta-Glucans	155-166	interleukin 1 alpha	Mus musculus	206-214
32224209-0	2020	beta-glucan augments IL-1beta production by activating the JAK2/STAT3 pathway in cultured rabbit keratinocytes.	beta-Glucans	0-11	interleukin-1 alpha	Oryctolagus cuniculus	21-29
32224209-0	2020	beta-glucan augments IL-1beta production by activating the JAK2/STAT3 pathway in cultured rabbit keratinocytes.	beta-Glucans	0-11	tyrosine-protein kinase JAK2	Oryctolagus cuniculus	59-63
32224209-0	2020	beta-glucan augments IL-1beta production by activating the JAK2/STAT3 pathway in cultured rabbit keratinocytes.	beta-Glucans	0-11	signal transducer and activator of transcription 3	Oryctolagus cuniculus	64-69
32596527-10	2020	Exo1 was predicted to reside at the cell membrane and hydrolyze cell wall beta-glucan during cell growth.	beta-Glucans	74-85	exonuclease 1	Homo sapiens	0-4
32203766-5	2020	Also, both L-137 and BG helped Nile tilapia to have high phagocytosis activity and relative expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) and interferon-gamma (INF-gamma) genes.	beta-Glucans	21-23	tumor necrosis factor b (TNF superfamily, member 2)	Oreochromis niloticus	106-133
32520965-11	2020	Expression of intestinal interleukin-18 (IL-18) in NZW rabbits treated with 0.25 and 0.5 doses of beta-glucan was significantly upregulated and enhanced the immune response.	beta-Glucans	98-109	interleukin-18	Oryctolagus cuniculus	25-39
32520965-11	2020	Expression of intestinal interleukin-18 (IL-18) in NZW rabbits treated with 0.25 and 0.5 doses of beta-glucan was significantly upregulated and enhanced the immune response.	beta-Glucans	98-109	interleukin-18	Oryctolagus cuniculus	41-46
32520965-12	2020	beta-glucan upregulated the expression of intestinal occludin mRNA particularly at dose 0.5 beta-glucan as well as upregulated intestinal superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPx1), which modulates anti-inflammatory and antioxidant properties.	beta-Glucans	0-11	occludin	Oryctolagus cuniculus	53-61
32520965-12	2020	beta-glucan upregulated the expression of intestinal occludin mRNA particularly at dose 0.5 beta-glucan as well as upregulated intestinal superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPx1), which modulates anti-inflammatory and antioxidant properties.	beta-Glucans	0-11	superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	162-166
32520965-12	2020	beta-glucan upregulated the expression of intestinal occludin mRNA particularly at dose 0.5 beta-glucan as well as upregulated intestinal superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPx1), which modulates anti-inflammatory and antioxidant properties.	beta-Glucans	0-11	glutathione peroxidase 1	Oryctolagus cuniculus	172-196
32520965-12	2020	beta-glucan upregulated the expression of intestinal occludin mRNA particularly at dose 0.5 beta-glucan as well as upregulated intestinal superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPx1), which modulates anti-inflammatory and antioxidant properties.	beta-Glucans	0-11	glutathione peroxidase 1	Oryctolagus cuniculus	198-202
32520965-12	2020	beta-glucan upregulated the expression of intestinal occludin mRNA particularly at dose 0.5 beta-glucan as well as upregulated intestinal superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPx1), which modulates anti-inflammatory and antioxidant properties.	beta-Glucans	92-103	occludin	Oryctolagus cuniculus	53-61
32523023-3	2020	Previously, adipocytes were shown to produce toll-like receptor 2 (TLR2), a beta-glucan receptor, suggesting that they could respond to beta-glucan on the fungal cell wall.	beta-Glucans	76-87	toll-like receptor 2	Mus musculus	45-65
32523023-3	2020	Previously, adipocytes were shown to produce toll-like receptor 2 (TLR2), a beta-glucan receptor, suggesting that they could respond to beta-glucan on the fungal cell wall.	beta-Glucans	76-87	toll-like receptor 2	Mus musculus	67-71
32503178-0	2020	Endo-1,3(4)-beta-Glucanase-Treatment of Oat beta-Glucan Enhances Fermentability by Infant Fecal Microbiota, Stimulates Dectin-1 Activation and Attenuates Inflammatory Responses in Immature Dendritic Cells.	beta-Glucans	12-23	C-type lectin domain containing 7A	Homo sapiens	119-127
32503178-6	2020	Fermentation of media supplemented with native and enzyme-treated oat beta-glucans increased the relative abundance of Enterococcus and attenuated pro-inflammatory cytokine production (IL-1beta, IL-6, TNFalpha) in immature dendritic cells.	beta-Glucans	70-82	interleukin 1 alpha	Homo sapiens	185-193
32503178-6	2020	Fermentation of media supplemented with native and enzyme-treated oat beta-glucans increased the relative abundance of Enterococcus and attenuated pro-inflammatory cytokine production (IL-1beta, IL-6, TNFalpha) in immature dendritic cells.	beta-Glucans	70-82	interleukin 6	Homo sapiens	195-199
32503178-6	2020	Fermentation of media supplemented with native and enzyme-treated oat beta-glucans increased the relative abundance of Enterococcus and attenuated pro-inflammatory cytokine production (IL-1beta, IL-6, TNFalpha) in immature dendritic cells.	beta-Glucans	70-82	tumor necrosis factor	Homo sapiens	201-209
32503178-8	2020	This attenuation might result from the enhanced ability of fermented oat beta-glucan to stimulate Dectin-1 receptors.	beta-Glucans	73-84	C-type lectin domain containing 7A	Homo sapiens	98-106
32203766-5	2020	Also, both L-137 and BG helped Nile tilapia to have high phagocytosis activity and relative expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) and interferon-gamma (INF-gamma) genes.	beta-Glucans	21-23	interleukin-1 beta	Oreochromis niloticus	150-168
32203766-5	2020	Also, both L-137 and BG helped Nile tilapia to have high phagocytosis activity and relative expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) and interferon-gamma (INF-gamma) genes.	beta-Glucans	21-23	interleukin-1 beta	Oreochromis niloticus	170-178
32203766-10	2020	TNF-alpha, IL-1beta, and INF-gamma expressions were upregulated by L-137 and/or BG.	beta-Glucans	80-82	interleukin-1 beta	Oreochromis niloticus	11-19
32433977-0	2020	beta-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.	beta-Glucans	0-11	interleukin 1 complex	Mus musculus	109-113
32528505-5	2020	fugu5-1 showed cuticle defects, cell swelling, reduced beta-glucan levels, and vein malformation in the leaves, suggesting cell wall weakening and cell lethality.	beta-Glucans	55-66	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	0-5
32433977-5	2020	The protective signature of beta-glucan is mediated via IL-1 signaling, as beta-glucan shows no protection in mice lacking a functional IL-1 receptor (IL1R-/-).	beta-Glucans	28-39	interleukin 1 complex	Mus musculus	56-60
32391005-1	2020	beta-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of beta-(1,3) and/or beta-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.	beta-Glucans	0-12	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	110-119
32393780-3	2020	Soluble beta-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monocytes and induces the release of TGF-beta1-transporting vesicles.	beta-Glucans	8-19	integrin alpha M	Mus musculus	69-72
32393780-3	2020	Soluble beta-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monocytes and induces the release of TGF-beta1-transporting vesicles.	beta-Glucans	8-19	integrin alpha M	Mus musculus	88-93
32393780-3	2020	Soluble beta-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monocytes and induces the release of TGF-beta1-transporting vesicles.	beta-Glucans	8-19	transforming growth factor beta 1	Homo sapiens	140-149
32323263-6	2020	Real-time PCR analysis revealed a decreased expression of Oct4 and Sox2 genes in treatment of cells with beta-glucan compared with control group.	beta-Glucans	105-116	POU domain, class 5, transcription factor 1	Mus musculus	58-62
32323263-6	2020	Real-time PCR analysis revealed a decreased expression of Oct4 and Sox2 genes in treatment of cells with beta-glucan compared with control group.	beta-Glucans	105-116	SRY (sex determining region Y)-box 2	Mus musculus	67-71
32323263-7	2020	Since the extracted beta-glucan showed an inhibitory effect on the expression of Oct4 and Sox2 genes involved in LL/2 metastasis, therefore, beta-glucan can be considered as an anti-tumor agent because of its anti-metastatic properties, however, more in vitro and in vivo studies are needed to provide further evidence on this topic in the future.	beta-Glucans	20-31	POU domain, class 5, transcription factor 1	Mus musculus	81-85
32323263-7	2020	Since the extracted beta-glucan showed an inhibitory effect on the expression of Oct4 and Sox2 genes involved in LL/2 metastasis, therefore, beta-glucan can be considered as an anti-tumor agent because of its anti-metastatic properties, however, more in vitro and in vivo studies are needed to provide further evidence on this topic in the future.	beta-Glucans	20-31	SRY (sex determining region Y)-box 2	Mus musculus	90-94
32323263-7	2020	Since the extracted beta-glucan showed an inhibitory effect on the expression of Oct4 and Sox2 genes involved in LL/2 metastasis, therefore, beta-glucan can be considered as an anti-tumor agent because of its anti-metastatic properties, however, more in vitro and in vivo studies are needed to provide further evidence on this topic in the future.	beta-Glucans	141-152	POU domain, class 5, transcription factor 1	Mus musculus	81-85
32323263-7	2020	Since the extracted beta-glucan showed an inhibitory effect on the expression of Oct4 and Sox2 genes involved in LL/2 metastasis, therefore, beta-glucan can be considered as an anti-tumor agent because of its anti-metastatic properties, however, more in vitro and in vivo studies are needed to provide further evidence on this topic in the future.	beta-Glucans	141-152	SRY (sex determining region Y)-box 2	Mus musculus	90-94
32391005-1	2020	beta-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of beta-(1,3) and/or beta-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.	beta-Glucans	0-12	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	128-137
32320649-4	2020	Recapitulation of beta-glucan training in vivo additionally identifies Set7-dependent changes in gene expression previously associated with the modulation of myelopoiesis progenitors in trained immunity.	beta-Glucans	18-29	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	71-75
32316136-8	2020	The effects of beta-glucans are mediated by Toll-like receptors, by dectin-1, and possibly by other receptors.	beta-Glucans	15-27	C-type lectin domain containing 7A	Homo sapiens	68-76
32138344-3	2020	Beta-glucans reduced mean LDL-Cholesterol (LDL-C) levels from baseline by 12.2% (95%CI: -15.4 to -3.8) after 4 weeks of supplementation and by 15.1% (95%CI: -17.8 to -5.9) after 8 weeks of supplementation (p < 0.01 for both comparison and versus placebo).	beta-Glucans	0-12	component of oligomeric golgi complex 2	Homo sapiens	26-41
32175921-7	2020	Importantly, beta-glucan treatment reduced c-MAF expression in macrophages and monocytes from patients with non-small cell lung cancer (NSCLC) where c-MAF is overexpressed.	beta-Glucans	13-24	MAF bZIP transcription factor	Homo sapiens	43-48
32175921-7	2020	Importantly, beta-glucan treatment reduced c-MAF expression in macrophages and monocytes from patients with non-small cell lung cancer (NSCLC) where c-MAF is overexpressed.	beta-Glucans	13-24	MAF bZIP transcription factor	Homo sapiens	149-154
32138344-3	2020	Beta-glucans reduced mean LDL-Cholesterol (LDL-C) levels from baseline by 12.2% (95%CI: -15.4 to -3.8) after 4 weeks of supplementation and by 15.1% (95%CI: -17.8 to -5.9) after 8 weeks of supplementation (p < 0.01 for both comparison and versus placebo).	beta-Glucans	0-12	component of oligomeric golgi complex 2	Homo sapiens	26-31
31509298-0	2019	Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1beta production to beta-glucan ligands in a TLR-independent manner.	beta-Glucans	91-102	spleen associated tyrosine kinase	Homo sapiens	0-3
32098265-7	2020	In the ileum, beta-glucan supplementation showed lower relative mRNA expression of toll-like receptor 5 (TLR-5) (p = 0.0387) compared to anthocyanin treatment.	beta-Glucans	14-25	toll like receptor 5	Gallus gallus	83-103
32098265-7	2020	In the ileum, beta-glucan supplementation showed lower relative mRNA expression of toll-like receptor 5 (TLR-5) (p = 0.0387) compared to anthocyanin treatment.	beta-Glucans	14-25	toll like receptor 5	Gallus gallus	105-110
31968666-0	2020	Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel beta-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation.	beta-Glucans	71-82	tumor necrosis factor	Mus musculus	31-58
32089236-4	2020	Most of the antitumor polysaccharides belong to conserved beta-glucans, with a linear beta-(1 3)-glucan backbone and attached beta-(1 6) branch.	beta-Glucans	58-70	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	86-95
32089236-4	2020	Most of the antitumor polysaccharides belong to conserved beta-glucans, with a linear beta-(1 3)-glucan backbone and attached beta-(1 6) branch.	beta-Glucans	58-70	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	126-135
32089236-7	2020	beta-Glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6, then trigger both innate and adaptive response and enhance opsonic and nonopsonic phagocytosis.	beta-Glucans	0-12	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	86-89
32089236-7	2020	beta-Glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6, then trigger both innate and adaptive response and enhance opsonic and nonopsonic phagocytosis.	beta-Glucans	0-12	toll like receptor 2	Homo sapiens	95-102
31509298-0	2019	Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1beta production to beta-glucan ligands in a TLR-independent manner.	beta-Glucans	91-102	interleukin 1 alpha	Homo sapiens	68-76
31509298-3	2019	Here, we show that activation of DCs with fungal-associated beta-glucan ligands induces acute glycolytic reprogramming that supports the production of IL-1beta and its secretion subsequent to NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.	beta-Glucans	60-71	interleukin 1 alpha	Homo sapiens	151-159
31509298-3	2019	Here, we show that activation of DCs with fungal-associated beta-glucan ligands induces acute glycolytic reprogramming that supports the production of IL-1beta and its secretion subsequent to NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.	beta-Glucans	60-71	NLR family pyrin domain containing 3	Homo sapiens	192-240
31509298-3	2019	Here, we show that activation of DCs with fungal-associated beta-glucan ligands induces acute glycolytic reprogramming that supports the production of IL-1beta and its secretion subsequent to NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.	beta-Glucans	60-71	NLR family pyrin domain containing 3	Homo sapiens	242-247
30430579-2	2019	These enzymes hydrolyze beta-glucans containing beta-1,3 and beta-1,4 linkages, such as cereal beta-glucans and lichenan.	beta-Glucans	24-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	48-56
31394148-9	2019	Consumption of soy pectin and oat beta-glucan enriched foods to produce targeted SCFAs in vivo could be a potential strategy to lower fat mass accumulation and a potential tool to manage obesity.	beta-Glucans	34-45	FAT atypical cadherin 1	Rattus norvegicus	134-137
31320072-0	2019	Structural studies of a water insoluble beta-glucan from Pleurotus djamor and its cytotoxic effect against PA1, ovarian carcinoma cells.	beta-Glucans	40-51	PAXIP1 associated glutamate rich protein 1	Homo sapiens	107-110
31320072-4	2019	The water insoluble beta-glucan showed cytotoxic effect against PA1 cells, where~50% population was destroyed at 100 mug/mL concentration, and almost all cells at 250 mug/mL concentration.	beta-Glucans	20-31	PAXIP1 associated glutamate rich protein 1	Homo sapiens	64-67
31343168-1	2019	In this study, an immunologically active novel microparticulate mushroom beta-glucan (PRA-1p) was prepared using an alkali-soluble glucan PRA-1 by an emulsification and cross-linking method.	beta-Glucans	73-84	Rab acceptor 1 (prenylated)	Mus musculus	86-92
31343168-1	2019	In this study, an immunologically active novel microparticulate mushroom beta-glucan (PRA-1p) was prepared using an alkali-soluble glucan PRA-1 by an emulsification and cross-linking method.	beta-Glucans	73-84	Rab acceptor 1 (prenylated)	Mus musculus	86-91
30418569-4	2019	Dectin-1 recognizes beta-glucan and plays an important role against fungal cells.	beta-Glucans	20-31	C-type lectin domain containing 7A	Homo sapiens	0-8
31357461-2	2019	Cereal beta-glucans have a specific combination of beta-(1 4) and beta-(1 3) linkages into linear long-chain polysaccharides of high molecular weight.	beta-Glucans	7-19	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	51-60
31357461-2	2019	Cereal beta-glucans have a specific combination of beta-(1 4) and beta-(1 3) linkages into linear long-chain polysaccharides of high molecular weight.	beta-Glucans	7-19	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	66-75
31291578-8	2019	Thus, in neutrophils, EphA2 serves as a receptor for beta-glucans that augments Fcgamma receptor-mediated antifungal activity and controls early fungal proliferation during OPC.	beta-Glucans	53-65	Eph receptor A2	Mus musculus	22-27
30879681-0	2019	Inhibition of tumor growth by beta-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice.	beta-Glucans	30-42	CD4 antigen	Mus musculus	61-64
30879681-4	2019	It was found that beta-glucans up-regulated CD4+ T cell level in lymphoid organs decreased by tumor-burden, indicating promotion of immunomodulation.	beta-Glucans	18-30	CD4 antigen	Mus musculus	44-47
30879681-6	2019	Furthermore, beta-glucans not only targeted to lymphoid organs and increased CD4+ T cells number, but also enhanced CD4+ T cells and neutrophils populations in tumors.	beta-Glucans	13-25	CD4 antigen	Mus musculus	77-80
30879681-6	2019	Furthermore, beta-glucans not only targeted to lymphoid organs and increased CD4+ T cells number, but also enhanced CD4+ T cells and neutrophils populations in tumors.	beta-Glucans	13-25	CD4 antigen	Mus musculus	116-119
30879681-7	2019	It was proposed that beta-glucans promoted CD4+ T cell immunomodulation and neutrophils infiltration into tumors, leading to tumor growth inhibition.	beta-Glucans	21-33	CD4 antigen	Mus musculus	43-46
30955255-6	2019	We found that overexpression of Pgm2 (phosphoglucomutase) and Rho1 (a GTPase for activating glucan synthesis) significantly increased beta-glucan accumulation.	beta-Glucans	134-145	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	32-57
30955255-6	2019	We found that overexpression of Pgm2 (phosphoglucomutase) and Rho1 (a GTPase for activating glucan synthesis) significantly increased beta-glucan accumulation.	beta-Glucans	134-145	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	62-66
31037071-5	2019	Results: beta-Glucan-, oS100A4-, HMBG1-, and HSP90-pretreated monocytes showed increased IL-6 responses to LPS re-stimulation.	beta-Glucans	9-20	interleukin 6	Homo sapiens	89-93
31037071-6	2019	beta-Glucan, oS100A and tenascin C induced training of monocytes to release more TNFalpha.	beta-Glucans	0-11	tumor necrosis factor	Homo sapiens	81-89
31535163-1	2019	KEY MESSAGE: Wheat-barley group-7 recombinant chromosomes were selected using molecular cytogenetics and SNP markers; increased grain beta-glucan content was observed in wheat plants with two and four copies of HvCslF6.	beta-Glucans	134-145	CslF6	Hordeum vulgare	211-218
31535163-9	2019	Plants, comprising barley cellulose synthase-like F6 gene (HvCslF6), responsible for beta-glucan synthesis, had a higher grain beta-glucan content than the wheat control.	beta-Glucans	85-96	CslF6	Hordeum vulgare	59-66
31535163-9	2019	Plants, comprising barley cellulose synthase-like F6 gene (HvCslF6), responsible for beta-glucan synthesis, had a higher grain beta-glucan content than the wheat control.	beta-Glucans	127-138	CslF6	Hordeum vulgare	59-66
31535163-11	2019	It is hypothesized that further increases in the beta-glucan content in wheat grain can be obtained by increasing the number of HvCslF6 copies through combining several recombinant chromosomes in one line.	beta-Glucans	49-60	CslF6	Hordeum vulgare	128-135
31535163-12	2019	The wheat lines with four copies of HvCslF6 exceeded the beta-glucan content of the lines with two copies.	beta-Glucans	57-68	CslF6	Hordeum vulgare	36-43
30284595-10	2019	Several differentially expressed genes in the beta-glucan-supplemented groups encoded proteins belonging to TLR and NLR signaling pathways, as well as prostaglandin synthesis and regulation pathways.	beta-Glucans	46-57	C-X-C motif chemokine receptor 5	Rattus norvegicus	116-119
30284595-11	2019	Both beta-glucans up-regulated the expression of Atg10, which belongs to the family of autophagy-related genes, suggesting a possible link between autophagy induction and beta-glucan supplementation.	beta-Glucans	5-17	autophagy related 10	Rattus norvegicus	49-54
30284595-11	2019	Both beta-glucans up-regulated the expression of Atg10, which belongs to the family of autophagy-related genes, suggesting a possible link between autophagy induction and beta-glucan supplementation.	beta-Glucans	5-16	autophagy related 10	Rattus norvegicus	49-54
31170489-8	2019	Furthermore, orally administered beta-glucan significantly induced the expression of IFN-gamma and IL-2 in splenocytes of gemcitabine-treated mice.	beta-Glucans	33-44	interferon gamma	Mus musculus	85-94
31170489-8	2019	Furthermore, orally administered beta-glucan significantly induced the expression of IFN-gamma and IL-2 in splenocytes of gemcitabine-treated mice.	beta-Glucans	33-44	interleukin 2	Mus musculus	99-103
31229067-5	2019	Furthermore, beta-glucan treatment alleviated the gastric oxidative stress injury in vehicle rats through increasing the activity of superoxide dismutase and catalase, decreasing the level of malondialdehyde.	beta-Glucans	13-24	catalase	Rattus norvegicus	158-166
31229067-6	2019	In addition, beta-glucan treatment also could decrease the level of interleukin-6 and tumor necrosis factor alpha and increased level of prostaglandin E2, nitric oxide.	beta-Glucans	13-24	interleukin 6	Mus musculus	68-113
31178861-5	2019	In contrast, macrophages trained with beta-glucan or Bacillus Calmette-Guerin had enhanced TNF production upon re-stimulation with Pam3cys or LPS.	beta-Glucans	38-49	tumor necrosis factor	Mus musculus	91-94
31098636-4	2019	Exposure to curdlan, a type of beta-glucan, suppressed cell death and led to the accumulation of a sub-G1-phase population upon A. actinomycetemcomitans invasion under conditions of constitutive expression of dectin-1.	beta-Glucans	31-42	C-type lectin domain family 7, member a	Mus musculus	209-217
30430579-2	2019	These enzymes hydrolyze beta-glucans containing beta-1,3 and beta-1,4 linkages, such as cereal beta-glucans and lichenan.	beta-Glucans	24-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69
30430579-2	2019	These enzymes hydrolyze beta-glucans containing beta-1,3 and beta-1,4 linkages, such as cereal beta-glucans and lichenan.	beta-Glucans	95-107	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	48-56
30430579-2	2019	These enzymes hydrolyze beta-glucans containing beta-1,3 and beta-1,4 linkages, such as cereal beta-glucans and lichenan.	beta-Glucans	95-107	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69
30557642-3	2019	beta-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results of RT-PCT.	beta-Glucans	0-11	peroxisome proliferator-activated receptor gamma	Danio rerio	68-74
30557642-3	2019	beta-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results of RT-PCT.	beta-Glucans	0-11	microsomal triglyceride transfer protein	Danio rerio	76-79
30557642-3	2019	beta-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results of RT-PCT.	beta-Glucans	0-11	fatty acid binding protein 10a, liver basic	Danio rerio	81-87
30557642-3	2019	beta-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results of RT-PCT.	beta-Glucans	0-11	fatty acid binding protein 2, intestinal	Danio rerio	89-94
30557642-4	2019	beta-Glucan lowered the level of C/EBP alpha, c SREBP1, LXR alpha, PPAR gamma by WB analysis, which were accompanied by an increase level in LC3 II/LC3 I and a decline level in p62 in dose-dependent manner.	beta-Glucans	0-11	CCAAT enhancer binding protein alpha	Danio rerio	33-44
30557642-4	2019	beta-Glucan lowered the level of C/EBP alpha, c SREBP1, LXR alpha, PPAR gamma by WB analysis, which were accompanied by an increase level in LC3 II/LC3 I and a decline level in p62 in dose-dependent manner.	beta-Glucans	0-11	sterol regulatory element binding transcription factor 1	Danio rerio	48-54
30557642-4	2019	beta-Glucan lowered the level of C/EBP alpha, c SREBP1, LXR alpha, PPAR gamma by WB analysis, which were accompanied by an increase level in LC3 II/LC3 I and a decline level in p62 in dose-dependent manner.	beta-Glucans	0-11	nuclear receptor subfamily 1, group H, member 3	Danio rerio	56-65
30557642-4	2019	beta-Glucan lowered the level of C/EBP alpha, c SREBP1, LXR alpha, PPAR gamma by WB analysis, which were accompanied by an increase level in LC3 II/LC3 I and a decline level in p62 in dose-dependent manner.	beta-Glucans	0-11	KH domain containing, RNA binding, signal transduction associated 1a	Danio rerio	177-180
30863400-3	2019	In mammals, Dectin-1 is a member of the C-type lectin receptor (CLR) family and the best-described receptor for beta-glucans.	beta-Glucans	112-124	C-type lectin domain containing 7A	Homo sapiens	12-20
29970897-0	2019	Complex consisting of antisense DNA and beta-glucan promotes internalization into cell through Dectin-1 and hybridizes with target mRNA in cytosol.	beta-Glucans	40-51	C-type lectin domain containing 7A	Homo sapiens	95-103
30792715-10	2019	Induced levels of il1b and il8 were also observed after treatment with nucleotides and beta-glucans.	beta-Glucans	87-99	interleukin-1 beta	Oncorhynchus mykiss	18-22
30792715-10	2019	Induced levels of il1b and il8 were also observed after treatment with nucleotides and beta-glucans.	beta-Glucans	87-99	putative cxc chemokine	Oncorhynchus mykiss	27-30
30760610-8	2019	Dectin-1 is a mammalian innate immune receptor in the membrane of some leukocytes that binds as a dimer to beta-glucans found in fungal cell walls, signaling fungal infection.	beta-Glucans	107-119	C-type lectin domain containing 7A	Homo sapiens	0-8
30760610-9	2019	Using a novel protocol, we coated AmB-LLs with Dectin-1"s beta-glucan binding domain to make DEC-AmB-LLs.	beta-Glucans	58-69	C-type lectin domain containing 7A	Homo sapiens	47-55
30718974-13	2019	The feed additive substances inhibited the expression of proinflammatory mediators HSP70 and TNF-alpha; however, beta-glucan and fulvic acid elevated the production of the chemokine IL-8 mRNA in endotoxin-treated enterocytes.	beta-Glucans	113-124	C-X-C motif chemokine ligand 8	Sus scrofa	182-186
30088084-1	2019	beta-Glucan has been reported to activate dendritic cells (DCs), and activated DCs, subsequently, promote Th1 and cytotoxic T-lymphocyte priming and differentiation in vitro.	beta-Glucans	0-11	negative elongation factor complex member C/D	Homo sapiens	106-109
30088084-7	2019	Further examination demonstrated that blockade of autophagy in beta-glucan-induced DCs significantly attenuated IFN-gamma production by co-cultured CD4 + T cells and inhibited the proliferation and differentiation of CD4 + T cells.	beta-Glucans	63-74	interferon gamma	Homo sapiens	112-121
30293776-3	2019	In contrast, induction of trained immunity by beta-glucan counteracted tolerance induced in a model of human endotoxemia by inhibiting the expression of immune-responsive gene 1 (IRG1), the enzyme that controls itaconate synthesis.	beta-Glucans	46-57	aconitate decarboxylase 1	Homo sapiens	153-177
30293776-3	2019	In contrast, induction of trained immunity by beta-glucan counteracted tolerance induced in a model of human endotoxemia by inhibiting the expression of immune-responsive gene 1 (IRG1), the enzyme that controls itaconate synthesis.	beta-Glucans	46-57	aconitate decarboxylase 1	Homo sapiens	179-183
30293776-4	2019	beta-Glucan also increased the expression of succinate dehydrogenase (SDH), contributing to the integrity of the TCA cycle and leading to an enhanced innate immune response after secondary stimulation.	beta-Glucans	0-11	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	45-68
30293776-4	2019	beta-Glucan also increased the expression of succinate dehydrogenase (SDH), contributing to the integrity of the TCA cycle and leading to an enhanced innate immune response after secondary stimulation.	beta-Glucans	0-11	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	70-73
30104216-3	2018	The purified rCpa1 was encapsulated into four types of yeast cell wall particles containing beta-glucan, mannan, and chitin in various proportions or was mixed with an oligonucleotide (ODN) containing two methylated dinucleotide CpG motifs.	beta-Glucans	92-103	carboxypeptidase A1	Rattus norvegicus	13-18
30193167-3	2018	In the anterior intestine, beta-glucan increased MTs levels, activities of Cu/Zn-SOD, CAT and iNOS, mRNA levels of MTs, CAT, iNOS, ATP7A and ATP7B, and reduced Cu content and CTR1 gene expression to inhibite Cu-induced MDA.	beta-Glucans	27-38	catalase	Larimichthys crocea	86-89
30193167-3	2018	In the anterior intestine, beta-glucan increased MTs levels, activities of Cu/Zn-SOD, CAT and iNOS, mRNA levels of MTs, CAT, iNOS, ATP7A and ATP7B, and reduced Cu content and CTR1 gene expression to inhibite Cu-induced MDA.	beta-Glucans	27-38	catalase	Larimichthys crocea	120-123
30193167-3	2018	In the anterior intestine, beta-glucan increased MTs levels, activities of Cu/Zn-SOD, CAT and iNOS, mRNA levels of MTs, CAT, iNOS, ATP7A and ATP7B, and reduced Cu content and CTR1 gene expression to inhibite Cu-induced MDA.	beta-Glucans	27-38	copper-transporting ATPase 1	Larimichthys crocea	131-136
30193167-5	2018	In the mid intestine, beta-glucan increased activities of Cu/Zn-SOD and iNOS, mRNA levels of Cu/Zn-SOD, CAT and iNOS to maintain MDA content.	beta-Glucans	22-33	catalase	Larimichthys crocea	104-107
30524506-11	2018	Oral administration of beta-glucans to mice decreased the overgrowth of aerobic bacteria and IL-1beta expression while L. johnsonii and B. thetaiotaomicron populations increased significantly.	beta-Glucans	23-35	interleukin 1 beta	Mus musculus	93-101
30420978-1	2018	We present the preparation, morphological analysis, and rheological characterization of ultra-low solid content gels prepared by physically cross-linking TEMPO-oxidized cellulose nanofibrils (TEMPO-CNF) with the soluble plant-cell-wall polysaccharide, mixed-linkage beta-glucan (MLG).	beta-Glucans	266-277	NPHS1 adhesion molecule, nephrin	Homo sapiens	198-201
30431070-0	2019	beta-glucan, a dectin-1 ligand, promotes macrophage M1 polarization via NF-kappaB/autophagy pathway.	beta-Glucans	0-11	C-type lectin domain family 7, member a	Mus musculus	15-23
30431070-4	2019	Additionally, dectin-1 small interfering RNA (siRNA), autophagy inducer rapamycin and NF-kappaB inhibitor SN50 reversed the effects of beta-glucan on autophagy level and macrophage M1 polarization, suggesting that dectin-1 and NF-kappaB are upstream of autophagy in beta-glucan-induced macrophage M1 polarization.	beta-Glucans	135-146	C-type lectin domain family 7, member a	Mus musculus	14-22
30431070-4	2019	Additionally, dectin-1 small interfering RNA (siRNA), autophagy inducer rapamycin and NF-kappaB inhibitor SN50 reversed the effects of beta-glucan on autophagy level and macrophage M1 polarization, suggesting that dectin-1 and NF-kappaB are upstream of autophagy in beta-glucan-induced macrophage M1 polarization.	beta-Glucans	135-146	C-type lectin domain family 7, member a	Mus musculus	214-222
30431070-4	2019	Additionally, dectin-1 small interfering RNA (siRNA), autophagy inducer rapamycin and NF-kappaB inhibitor SN50 reversed the effects of beta-glucan on autophagy level and macrophage M1 polarization, suggesting that dectin-1 and NF-kappaB are upstream of autophagy in beta-glucan-induced macrophage M1 polarization.	beta-Glucans	266-277	C-type lectin domain family 7, member a	Mus musculus	14-22
30431070-4	2019	Additionally, dectin-1 small interfering RNA (siRNA), autophagy inducer rapamycin and NF-kappaB inhibitor SN50 reversed the effects of beta-glucan on autophagy level and macrophage M1 polarization, suggesting that dectin-1 and NF-kappaB are upstream of autophagy in beta-glucan-induced macrophage M1 polarization.	beta-Glucans	266-277	C-type lectin domain family 7, member a	Mus musculus	214-222
30431070-5	2019	Notably, simultaneous treatment with dectin-1 siRNA and SN50 exhibited similar effects on beta-glucan-reduced autophagy compared with dectin-1 siRNA treatment alone.	beta-Glucans	90-101	C-type lectin domain family 7, member a	Mus musculus	37-45
30431070-6	2019	These findings demonstrate that dectin-1 may mediate beta-glucan-reduced autophagy through NF-kappaB in macrophages.	beta-Glucans	53-64	C-type lectin domain family 7, member a	Mus musculus	32-40
30431070-7	2019	Accordingly, results from hematoxylin and eosin staining, western blotting and immunofluorescence staining demonstrated that beta-glucan accelerated the progress of atherosclerosis in apolipoprotein E-deficient mice and modulated expression of dectin-1, beclin-1 and light chain 3II/I in aortas similarly to that observed in macrophages.	beta-Glucans	125-136	C-type lectin domain family 7, member a	Mus musculus	244-252
30431070-7	2019	Accordingly, results from hematoxylin and eosin staining, western blotting and immunofluorescence staining demonstrated that beta-glucan accelerated the progress of atherosclerosis in apolipoprotein E-deficient mice and modulated expression of dectin-1, beclin-1 and light chain 3II/I in aortas similarly to that observed in macrophages.	beta-Glucans	125-136	beclin 1, autophagy related	Mus musculus	254-262
30431070-8	2019	These results indicate that dectin-1 activation by beta-glucan exerts atherogenic effects via converting macrophages into M1 phenotype in an NF-kappaB-autophagy-dependent pathway.	beta-Glucans	51-62	C-type lectin domain family 7, member a	Mus musculus	28-36
29920123-8	2019	Significant changes in levels of CRP were observed in the beta-glucan-supplemented group; levels of SAA and IL-6 were not changed.	beta-Glucans	58-69	C-reactive protein	Homo sapiens	33-36
29920123-9	2019	Leptin levels were significantly lowered in the beta-glucan-supplemented group and increased in the other groups.	beta-Glucans	48-59	leptin	Homo sapiens	0-6
30534737-0	2018	beta-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine.	beta-Glucans	0-11	mucin 1, cell surface associated	Homo sapiens	84-88
29953750-3	2018	MIF promoter, CATT-length-dependent gene expression in response to beta-glucan was assessed by gene reporter assays.	beta-Glucans	67-78	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	0-3
30380404-3	2018	We found that beta-glucan-trained macrophages from mice with a myeloid-specific deletion of the phosphatase SHIP-1 (LysMDeltaSHIP-1) showed enhanced proinflammatory cytokine production in response to lipopolysaccharide.	beta-Glucans	14-25	inositol polyphosphate-5-phosphatase D	Mus musculus	108-114
30380404-4	2018	Following beta-glucan training, SHIP-1-deficient macrophages exhibited increased phosphorylation of Akt and mTOR targets, correlating with augmented glycolytic metabolism.	beta-Glucans	10-21	thymoma viral proto-oncogene 1	Mus musculus	100-103
30380404-4	2018	Following beta-glucan training, SHIP-1-deficient macrophages exhibited increased phosphorylation of Akt and mTOR targets, correlating with augmented glycolytic metabolism.	beta-Glucans	10-21	mechanistic target of rapamycin kinase	Mus musculus	108-112
30104216-5	2018	Among the adjuvants tested, both GCPs and beta-glucan particles (GPs) were capable of stimulating a mixed Th1 and Th17 response.	beta-Glucans	42-53	negative elongation factor complex member C/D, Th1l	Mus musculus	106-109
30150283-2	2018	SKG mice have a point mutation in ZAP-70 that results in attenuated TCR signaling, altered thymic selection, and spontaneous production of autoreactive T cells that cause arthritis following exposure to microbial beta-glucans.	beta-Glucans	213-225	zeta-chain (TCR) associated protein kinase	Mus musculus	34-40
30185519-6	2018	In this study, we show that CD23 can recognize both alpha-mannan and beta-glucan from the cell wall of C. albicans or A. fumigatus but cannot recognize glucuronoxylomannan from Cryptococcus Through forming a complex with FcRgamma, CD23 can induce NF-kappaB activation.	beta-Glucans	69-80	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	28-32
29897456-0	2018	beta-Glucan-induced cooperative oligomerization of Dectin-1 C-type lectin-like domain.	beta-Glucans	0-11	C-type lectin domain family 7, member a	Mus musculus	51-59
30262772-6	2018	Training with beta-glucan resulted in higher cytokine production after TLR1/2, TLR4, and TLR7/8 stimulation.	beta-Glucans	14-25	toll-like receptor 1	Bos taurus	71-77
30262772-6	2018	Training with beta-glucan resulted in higher cytokine production after TLR1/2, TLR4, and TLR7/8 stimulation.	beta-Glucans	14-25	toll like receptor 4	Bos taurus	79-83
30262772-6	2018	Training with beta-glucan resulted in higher cytokine production after TLR1/2, TLR4, and TLR7/8 stimulation.	beta-Glucans	14-25	toll like receptor 7	Bos taurus	89-93
30049632-4	2018	When beta-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize beta-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on.	beta-Glucans	5-17	C-type lectin domain containing 7A	Homo sapiens	131-139
30049632-4	2018	When beta-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize beta-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on.	beta-Glucans	5-17	CD5 molecule	Homo sapiens	170-173
30049632-4	2018	When beta-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize beta-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on.	beta-Glucans	107-119	C-type lectin domain containing 7A	Homo sapiens	131-139
29920323-7	2018	GLP-1 was significantly reduced at 90 min (p = 0.021), blood glucose at 30 min (p = 0.008) and plasma insulin at 30 and 60 min (p = 0.002 and 0.017, respectively) following the oat beta-glucan breakfast when compared with the control breakfast.	beta-Glucans	181-192	glucagon like peptide 1 receptor	Homo sapiens	0-5
29895959-0	2018	Author Correction: EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans.	beta-Glucans	87-99	EPH receptor A2	Homo sapiens	19-24
29897456-12	2018	We suggest that the ligand-induced cooperative oligomer formation of Dectin-1 is physiologically relevant in sensing exogenous beta-glucan and triggering intracellular signaling.	beta-Glucans	127-138	C-type lectin domain family 7, member a	Mus musculus	69-77
29074300-6	2018	In mice cells, we also observed a Th17 pathway induction, with an increase on the IL-17A levels in lymphocytes cultured with beta-glucan pulsed DCs.	beta-Glucans	125-136	interleukin 17A	Mus musculus	82-88
29524446-5	2018	Additionally, up-regulation of the expression of a set of genes involved in innate immune response was detected in zebrafish intraperitoneally injected of beta-glucan: il1b, il6, il8, il10 and tnfa transcripts showed increased expression that appear to be rapid (2 days) but not long-lived (less than 2 weeks).	beta-Glucans	155-166	interleukin 1, beta	Danio rerio	168-172
29524446-5	2018	Additionally, up-regulation of the expression of a set of genes involved in innate immune response was detected in zebrafish intraperitoneally injected of beta-glucan: il1b, il6, il8, il10 and tnfa transcripts showed increased expression that appear to be rapid (2 days) but not long-lived (less than 2 weeks).	beta-Glucans	155-166	interleukin 6 (interferon, beta 2)	Danio rerio	174-177
29524446-5	2018	Additionally, up-regulation of the expression of a set of genes involved in innate immune response was detected in zebrafish intraperitoneally injected of beta-glucan: il1b, il6, il8, il10 and tnfa transcripts showed increased expression that appear to be rapid (2 days) but not long-lived (less than 2 weeks).	beta-Glucans	155-166	chemokine (C-X-C motif) ligand 8a	Danio rerio	179-182
29524446-5	2018	Additionally, up-regulation of the expression of a set of genes involved in innate immune response was detected in zebrafish intraperitoneally injected of beta-glucan: il1b, il6, il8, il10 and tnfa transcripts showed increased expression that appear to be rapid (2 days) but not long-lived (less than 2 weeks).	beta-Glucans	155-166	interleukin 10	Danio rerio	184-188
29236232-9	2018	Murine peritoneal macrophages cultivated with beta-glucan for 6 and 48 h showed an increase in TNF-alpha, IL-6 and nitric oxide release with increased polysaccharide concentrations.	beta-Glucans	46-57	tumor necrosis factor	Mus musculus	95-104
29236232-9	2018	Murine peritoneal macrophages cultivated with beta-glucan for 6 and 48 h showed an increase in TNF-alpha, IL-6 and nitric oxide release with increased polysaccharide concentrations.	beta-Glucans	46-57	interleukin 6	Mus musculus	106-110
29313961-7	2018	Sustained monocyte activation, induced by fungal beta-glucan particles upon actin cytoskeleton disruption, relies on Dectin-1 and results in the classical caspase-1 inflammasome formation through NLRP3, generation of an oxidative burst, NF-kappaB activation, and increased inflammatory cytokine release.	beta-Glucans	49-60	C-type lectin domain containing 7A	Homo sapiens	117-125
29313961-7	2018	Sustained monocyte activation, induced by fungal beta-glucan particles upon actin cytoskeleton disruption, relies on Dectin-1 and results in the classical caspase-1 inflammasome formation through NLRP3, generation of an oxidative burst, NF-kappaB activation, and increased inflammatory cytokine release.	beta-Glucans	49-60	caspase 1	Homo sapiens	155-164
29313961-7	2018	Sustained monocyte activation, induced by fungal beta-glucan particles upon actin cytoskeleton disruption, relies on Dectin-1 and results in the classical caspase-1 inflammasome formation through NLRP3, generation of an oxidative burst, NF-kappaB activation, and increased inflammatory cytokine release.	beta-Glucans	49-60	NLR family pyrin domain containing 3	Homo sapiens	196-201
29068000-0	2018	beta-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.	beta-Glucans	0-12	C-type lectin domain family 7, member a	Mus musculus	101-109
29068000-0	2018	beta-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.	beta-Glucans	0-12	interleukin 17F	Mus musculus	118-124
29068000-1	2018	Dectin-1 (gene symbol: Clec7a) is a receptor for beta-glucans that play an important role for the host defense against fungi.	beta-Glucans	49-61	C-type lectin domain family 7, member a	Mus musculus	0-8
29068000-1	2018	Dectin-1 (gene symbol: Clec7a) is a receptor for beta-glucans that play an important role for the host defense against fungi.	beta-Glucans	49-61	C-type lectin domain family 7, member a	Mus musculus	23-29
29068000-8	2018	These observations suggest that food-derived beta-glucans control the specific commensal microbiota via the Dectin-1-IL-17F-calprotectin axis to maintain the intestinal homeostasis.	beta-Glucans	45-57	C-type lectin domain family 7, member a	Mus musculus	108-116
29068000-8	2018	These observations suggest that food-derived beta-glucans control the specific commensal microbiota via the Dectin-1-IL-17F-calprotectin axis to maintain the intestinal homeostasis.	beta-Glucans	45-57	interleukin 17F	Mus musculus	117-123
29763881-0	2018	Orally administered brown seaweed-derived beta-glucan effectively restrained development of gastric dysplasia in A4gnt KO mice that spontaneously develop gastric adenocarcinoma.	beta-Glucans	42-53	alpha-1,4-N-acetylglucosaminyltransferase	Mus musculus	113-118
29763881-1	2018	beta-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing beta-(1,3)-d-linked glucose polymers with branches connected by either beta-(1,4) or beta-(1,6) glycosidic linkage.	beta-Glucans	0-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	172-181
29763881-1	2018	beta-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing beta-(1,3)-d-linked glucose polymers with branches connected by either beta-(1,4) or beta-(1,6) glycosidic linkage.	beta-Glucans	0-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	186-195
29763881-5	2018	Here we investigated the putative gastro-protective activity of brown seaweed-derived beta-glucan (Laminaran) against development of gastric dysplasia, precancerous lesion for gastric cancer in A4gnt KO mice.	beta-Glucans	86-97	alpha-1,4-N-acetylglucosaminyltransferase	Mus musculus	194-199
29896200-6	2018	Using an antibody to citrullinated histone 3 (H3Cit) as an indicator of PAD4 activity, we show that beta-glucan stimulated NETosis occurs in neutrophils from C57BL/6, but not PAD4-/- mice.	beta-Glucans	100-111	MMTV LTR integration site 4	Mus musculus	72-76
29440749-0	2018	Publisher Correction: EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans.	beta-Glucans	90-102	EPH receptor A2	Homo sapiens	22-27
29358941-10	2017	Therefore, we designed a CAR that targets beta-glucan, a sugar molecule found in most of the fungal cell walls, using the extracellular domain of Dectin-1, which binds to beta-glucan.	beta-Glucans	42-53	C-type lectin domain containing 7A	Homo sapiens	146-154
29124282-8	2018	Implicated in this increase, the barley cellulose synthase-like F6 gene (CslF6) responsible for beta-glucan synthesis was physically mapped near the centromere in the long arm of barley chromosome 7H.	beta-Glucans	96-107	CslF6	Hordeum vulgare	73-78
29063476-0	2018	Fungal beta-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production.	beta-Glucans	7-18	NLR family pyrin domain containing 3	Homo sapiens	33-38
29063476-3	2018	Also, the relationship between fungal beta-glucan and NLRP3 inflammasome is not clear yet.	beta-Glucans	38-49	NLR family pyrin domain containing 3	Homo sapiens	54-59
29063476-4	2018	In this study, we first identified that curdlan, a large particulate beta-glucan, could activate the NLRP3 inflammasome in LPS-primed human bronchial epithelial cells (HBECs).	beta-Glucans	69-80	NLR family pyrin domain containing 3	Homo sapiens	101-106
29358941-10	2017	Therefore, we designed a CAR that targets beta-glucan, a sugar molecule found in most of the fungal cell walls, using the extracellular domain of Dectin-1, which binds to beta-glucan.	beta-Glucans	171-182	C-type lectin domain containing 7A	Homo sapiens	146-154
29133884-0	2018	EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans.	beta-Glucans	68-80	Eph receptor A2	Mus musculus	0-5
29328910-3	2018	Administration of beta-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1beta and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis.	beta-Glucans	18-29	interleukin 1 beta	Mus musculus	225-233
29328910-3	2018	Administration of beta-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1beta and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis.	beta-Glucans	18-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	238-286
29328910-3	2018	Administration of beta-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1beta and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis.	beta-Glucans	18-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	288-294
29202301-2	2018	beta-Glucan-induced dectin-1 signalling activates the NLRP3 inflammasome, which in turn rapidly produces IL-1beta, a master regulator of inflammation.	beta-Glucans	0-11	C-type lectin domain family 7, member a	Mus musculus	20-28
29202301-2	2018	beta-Glucan-induced dectin-1 signalling activates the NLRP3 inflammasome, which in turn rapidly produces IL-1beta, a master regulator of inflammation.	beta-Glucans	0-11	NLR family, pyrin domain containing 3	Mus musculus	54-59
29202301-2	2018	beta-Glucan-induced dectin-1 signalling activates the NLRP3 inflammasome, which in turn rapidly produces IL-1beta, a master regulator of inflammation.	beta-Glucans	0-11	interleukin 1 beta	Mus musculus	105-113
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	spleen tyrosine kinase	Mus musculus	13-16
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	interleukin 1 beta	Mus musculus	67-75
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	spleen tyrosine kinase	Mus musculus	104-107
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	NLR family, pyrin domain containing 3	Mus musculus	129-134
29133884-3	2018	Here, we demonstrate that the ephrin type-A receptor 2 (EphA2) is an oral epithelial cell PRR that binds to exposed beta-glucans on the surface of the fungal pathogen Candida albicans.	beta-Glucans	116-128	Eph receptor A2	Mus musculus	56-61
29133884-6	2018	Our study reveals that EphA2 functions as a PRR for beta-glucans that senses epithelial cell fungal burden and is required for the maximal mucosal inflammatory response to C. albicans.	beta-Glucans	52-64	Eph receptor A2	Mus musculus	23-28
28757372-7	2017	Fucoidan and beta-glucans were observed to inhibit C3b-C5 interaction, and dextran sulfate was similarly active; however, rosmarinic acid had no measurable effect.	beta-Glucans	13-25	complement C3	Homo sapiens	51-54
29550680-8	2018	Interestingly, both XYL and GLU group showed higher expression levels of genes associated with intestinal barrier functions (zonulaoccludens 1 and claudin 1) and nutrient transportation (Na+-glucose co-transporter 1 and facilitated glucose transporter 2).	beta-Glucans	28-31	claudin 1	Sus scrofa	147-156
29550680-8	2018	Interestingly, both XYL and GLU group showed higher expression levels of genes associated with intestinal barrier functions (zonulaoccludens 1 and claudin 1) and nutrient transportation (Na+-glucose co-transporter 1 and facilitated glucose transporter 2).	beta-Glucans	28-31	solute carrier family 5 member 1	Sus scrofa	187-253
29249921-5	2017	Blood derived macrophages from rabbits administered in vivo with the beta-glucan supplemented diet showed higher IL-4, IFN-gamma and RAGE together with lower IL-10 relative expression, indicative of an ongoing immune response.	beta-Glucans	69-80	interleukin-4	Oryctolagus cuniculus	113-117
29249921-5	2017	Blood derived macrophages from rabbits administered in vivo with the beta-glucan supplemented diet showed higher IL-4, IFN-gamma and RAGE together with lower IL-10 relative expression, indicative of an ongoing immune response.	beta-Glucans	69-80	interferon gamma	Oryctolagus cuniculus	119-128
29249921-5	2017	Blood derived macrophages from rabbits administered in vivo with the beta-glucan supplemented diet showed higher IL-4, IFN-gamma and RAGE together with lower IL-10 relative expression, indicative of an ongoing immune response.	beta-Glucans	69-80	interleukin-10	Oryctolagus cuniculus	158-163
29170665-14	2017	In conclusion, this study describes a differential response of NLRP3 to beta-glucan and CpG antigens and identifies the NLRP3 inflammasome of human circulating B-lymphocytes as a modulator of the innate and adaptive immune systems.	beta-Glucans	72-83	NLR family pyrin domain containing 3	Homo sapiens	63-68
28882806-5	2017	In non-challenged group, variable effects of the two doses of beta-Glucans on the expression of the studied genes were observed; 0.1% induced higher expression of HSP70, CXC chemokine, MHC-IIbeta and MX genes.	beta-Glucans	62-74	heat shock cognate 71 kDa protein	Oreochromis niloticus	163-168
28882806-5	2017	In non-challenged group, variable effects of the two doses of beta-Glucans on the expression of the studied genes were observed; 0.1% induced higher expression of HSP70, CXC chemokine, MHC-IIbeta and MX genes.	beta-Glucans	62-74	MHC class II beta chain	Oreochromis niloticus	185-195
28882806-7	2017	However, with the challenged group, 0.2% beta-Glucans showed better effect than 0.1% at day one post challenge through significant up-regulation of GST, HSP, IL8, TNF-alpha, CXC, and MHC-IIbeta, meanwhile, the effect of 0.1% was only on the expression of HSP70, MHC-IIbeta, and TLR7 at day 3 post challenge.	beta-Glucans	41-53	interleukin-8	Oreochromis niloticus	158-161
28882806-7	2017	However, with the challenged group, 0.2% beta-Glucans showed better effect than 0.1% at day one post challenge through significant up-regulation of GST, HSP, IL8, TNF-alpha, CXC, and MHC-IIbeta, meanwhile, the effect of 0.1% was only on the expression of HSP70, MHC-IIbeta, and TLR7 at day 3 post challenge.	beta-Glucans	41-53	MHC class II beta chain	Oreochromis niloticus	183-193
28882806-7	2017	However, with the challenged group, 0.2% beta-Glucans showed better effect than 0.1% at day one post challenge through significant up-regulation of GST, HSP, IL8, TNF-alpha, CXC, and MHC-IIbeta, meanwhile, the effect of 0.1% was only on the expression of HSP70, MHC-IIbeta, and TLR7 at day 3 post challenge.	beta-Glucans	41-53	heat shock cognate 71 kDa protein	Oreochromis niloticus	255-260
28882806-7	2017	However, with the challenged group, 0.2% beta-Glucans showed better effect than 0.1% at day one post challenge through significant up-regulation of GST, HSP, IL8, TNF-alpha, CXC, and MHC-IIbeta, meanwhile, the effect of 0.1% was only on the expression of HSP70, MHC-IIbeta, and TLR7 at day 3 post challenge.	beta-Glucans	41-53	MHC class II beta chain	Oreochromis niloticus	262-272
28882806-7	2017	However, with the challenged group, 0.2% beta-Glucans showed better effect than 0.1% at day one post challenge through significant up-regulation of GST, HSP, IL8, TNF-alpha, CXC, and MHC-IIbeta, meanwhile, the effect of 0.1% was only on the expression of HSP70, MHC-IIbeta, and TLR7 at day 3 post challenge.	beta-Glucans	41-53	toll-like receptor 8	Oreochromis niloticus	278-282
29170665-8	2017	Our results show that the beta-glucan fungal cell wall carbohydrate stimulated B-lymphocytes to secrete IL-1beta in a process partially mediated by Dectin-1 activation via SYK and the transcription factors NF-kappaB and AP-1.	beta-Glucans	26-37	interleukin 1 beta	Homo sapiens	104-112
29170665-8	2017	Our results show that the beta-glucan fungal cell wall carbohydrate stimulated B-lymphocytes to secrete IL-1beta in a process partially mediated by Dectin-1 activation via SYK and the transcription factors NF-kappaB and AP-1.	beta-Glucans	26-37	C-type lectin domain containing 7A	Homo sapiens	148-156
28848046-3	2017	Dectin-1 is a well-characterized CLR that recognizes beta-glucan.	beta-Glucans	53-64	C-type lectin domain containing 7A	Homo sapiens	0-8
28848046-8	2017	Rather, we found that its intracellular domain renders human Dectin-1 reactive to low-valency beta-glucan ligand.	beta-Glucans	94-105	C-type lectin domain containing 7A	Homo sapiens	61-69
28848046-9	2017	Substitution with two amino acids, Glu2 and Pro5, located in the human Dectin-1 intracellular domain was sufficient to confer sensitivity to low-valency beta-glucan in mouse Dectin-1.	beta-Glucans	153-164	C-type lectin domain containing 7A	Homo sapiens	71-79
28848046-9	2017	Substitution with two amino acids, Glu2 and Pro5, located in the human Dectin-1 intracellular domain was sufficient to confer sensitivity to low-valency beta-glucan in mouse Dectin-1.	beta-Glucans	153-164	C-type lectin domain family 7, member a	Mus musculus	174-182
28848046-10	2017	Conversely, the introduction of mouse-specific amino acids, Lys2 and Ser5, to human Dectin-1 reduced the reactivity to low-valency beta-glucan.	beta-Glucans	131-142	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Mus musculus	60-64
28848046-10	2017	Conversely, the introduction of mouse-specific amino acids, Lys2 and Ser5, to human Dectin-1 reduced the reactivity to low-valency beta-glucan.	beta-Glucans	131-142	C-type lectin domain containing 7A	Homo sapiens	84-92
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	C-type lectin domain containing 7A	Rattus norvegicus	97-135
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	C-type lectin domain containing 7A	Rattus norvegicus	137-143
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	C-type lectin domain containing 7A	Rattus norvegicus	147-154
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	spleen associated tyrosine kinase	Rattus norvegicus	170-203
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	spleen associated tyrosine kinase	Rattus norvegicus	205-208
28624575-8	2017	Other rats subjected to water avoidance stress were given soluble beta-glucans, which antagonize C-type lectin domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a SYK inhibitor to reduce visceral hypersensitivity, or vehicle (control).	beta-Glucans	66-78	spleen associated tyrosine kinase	Rattus norvegicus	213-216
28624575-15	2017	Particulate beta-glucan (a DECTIN-1 agonist) induced mast cell degranulation in mesenteric windows and HMC-1 cells responded to fungal antigens by release of histamine.	beta-Glucans	12-23	C-type lectin domain containing 7A	Homo sapiens	27-35
28906456-1	2017	This study aimed to evaluate the effects of beta-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic beta-cell function (HOMA-BF) in diabetic rats with periodontal disease (PD).	beta-Glucans	44-55	tumor necrosis factor	Rattus norvegicus	149-158
28906456-1	2017	This study aimed to evaluate the effects of beta-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic beta-cell function (HOMA-BF) in diabetic rats with periodontal disease (PD).	beta-Glucans	44-55	interleukin 10	Rattus norvegicus	180-185
28906456-8	2017	beta-glucan reduced plasmatic levels of TNF-alpha in diabetic animals with PD and of IL-10 in animals with PD (p &lt; 0.05).	beta-Glucans	0-11	tumor necrosis factor	Rattus norvegicus	40-49
28906456-8	2017	beta-glucan reduced plasmatic levels of TNF-alpha in diabetic animals with PD and of IL-10 in animals with PD (p &lt; 0.05).	beta-Glucans	0-11	interleukin 10	Rattus norvegicus	85-90
28910320-7	2017	Expression levels of mx, tnfalpha, ifngamma, t-bet and nitr9 demonstrated dynamic changes in response to intra-coelomically administered beta glucan (a TLR2/6 ligand), Poly I:C (a TLR3 ligand) and resiquimod (R848) (a TLR7/8 ligand).	beta-Glucans	137-148	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	25-33
28910320-7	2017	Expression levels of mx, tnfalpha, ifngamma, t-bet and nitr9 demonstrated dynamic changes in response to intra-coelomically administered beta glucan (a TLR2/6 ligand), Poly I:C (a TLR3 ligand) and resiquimod (R848) (a TLR7/8 ligand).	beta-Glucans	137-148	T-box transcription factor 21	Danio rerio	45-50
28910320-7	2017	Expression levels of mx, tnfalpha, ifngamma, t-bet and nitr9 demonstrated dynamic changes in response to intra-coelomically administered beta glucan (a TLR2/6 ligand), Poly I:C (a TLR3 ligand) and resiquimod (R848) (a TLR7/8 ligand).	beta-Glucans	137-148	novel immune-type receptor 9	Danio rerio	55-60
28910320-7	2017	Expression levels of mx, tnfalpha, ifngamma, t-bet and nitr9 demonstrated dynamic changes in response to intra-coelomically administered beta glucan (a TLR2/6 ligand), Poly I:C (a TLR3 ligand) and resiquimod (R848) (a TLR7/8 ligand).	beta-Glucans	137-148	toll-like receptor 3	Danio rerio	180-184
28736555-0	2017	beta-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1beta Production.	beta-Glucans	0-11	C-type lectin domain containing 7A	Homo sapiens	26-34
28955331-0	2017	Molecular Analysis of a Short-term Model of beta-Glucans-Trained Immunity Highlights the Accessory Contribution of GM-CSF in Priming Mouse Macrophages Response.	beta-Glucans	44-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	115-121
28955331-1	2017	beta-Glucans (BGs) are glucose polymers present in the fungal cell wall (CW) and, as such, are recognized by innate immune cells as microbial-associated pattern through Dectin-1 receptor.	beta-Glucans	0-12	C-type lectin domain family 7, member a	Mus musculus	169-177
28408333-0	2017	Trans-generational enhancement of C-type lysozyme level in eggs of zebrafish by dietary beta-glucan.	beta-Glucans	88-99	lysozyme	Danio rerio	41-49
28408333-3	2017	Here we clearly showe that beta-glucan enhanced the level of C-type lysozyme in eggs of zebrafish, and the embryos derived from beta-glucan-treated zebrafish were more resistant to bacterial challenge than control embryos.	beta-Glucans	27-38	lysozyme	Danio rerio	68-76
28408333-3	2017	Here we clearly showe that beta-glucan enhanced the level of C-type lysozyme in eggs of zebrafish, and the embryos derived from beta-glucan-treated zebrafish were more resistant to bacterial challenge than control embryos.	beta-Glucans	128-139	lysozyme	Danio rerio	68-76
28408333-5	2017	In addition, we also showed that beta-glucan induced a significant increase in the synthesis of C-type lysozyme in previtellogenetic oocytes.	beta-Glucans	33-44	lysozyme	Danio rerio	103-111
28408333-6	2017	Therefore, we show for the first time that beta-glucan can enhance the lysozyme level in offspring via both inducing the transfer of the molecule from mothers to eggs and stimulating its endogenous production in oocytes.	beta-Glucans	43-54	lysozyme	Danio rerio	71-79
28228641-1	2017	The beta-1, 3 (d)-glucan (beta-glucan) present in the cell wall of Candida albicans induces epigenetic changes in human monocytes resulting in primed macrophages exhibiting increased cytokine responsiveness to reinfection.	beta-Glucans	26-37	hemoglobin, beta adult major chain	Mus musculus	4-13
28228641-7	2017	In vivo, 4 days after systemic administration of beta-glucan, mice were more responsive to LPS challenge as shown by the increased serum levels of TNFalpha, IL-6 and IL-10, an effect shown to be short lived as enhanced cytokine production was lost by day 20.	beta-Glucans	49-60	tumor necrosis factor	Mus musculus	147-155
28228641-7	2017	In vivo, 4 days after systemic administration of beta-glucan, mice were more responsive to LPS challenge as shown by the increased serum levels of TNFalpha, IL-6 and IL-10, an effect shown to be short lived as enhanced cytokine production was lost by day 20.	beta-Glucans	49-60	interleukin 6	Mus musculus	157-161
28228641-7	2017	In vivo, 4 days after systemic administration of beta-glucan, mice were more responsive to LPS challenge as shown by the increased serum levels of TNFalpha, IL-6 and IL-10, an effect shown to be short lived as enhanced cytokine production was lost by day 20.	beta-Glucans	49-60	interleukin 10	Mus musculus	166-171
28754958-6	2017	It also down-regulated reactive oxygen production and neutrophil extracellular trap formation by human PMNs stimulated with yeast-derived beta-glucans in the presence of TNFalpha, IFNgamma or GM-CSF.	beta-Glucans	138-150	tumor necrosis factor	Homo sapiens	170-178
28754958-6	2017	It also down-regulated reactive oxygen production and neutrophil extracellular trap formation by human PMNs stimulated with yeast-derived beta-glucans in the presence of TNFalpha, IFNgamma or GM-CSF.	beta-Glucans	138-150	interferon gamma	Homo sapiens	180-188
28754958-6	2017	It also down-regulated reactive oxygen production and neutrophil extracellular trap formation by human PMNs stimulated with yeast-derived beta-glucans in the presence of TNFalpha, IFNgamma or GM-CSF.	beta-Glucans	138-150	colony stimulating factor 2	Homo sapiens	192-198
28736555-5	2017	Furthermore, we show that the capacity to induce phagocytosis, and the relative IL-1beta production determined by beta-glucan size, regulates the composition of the cytokine milieu generated from DC.	beta-Glucans	114-125	interleukin 1 beta	Homo sapiens	80-88
28936221-8	2017	On the other hand, XZ147 had the most reduction of beta-glucan content under water stress than the other genotypes, which could be explained by the faster grain filling process and the less expression of beta-glucan synthase gene GSL7.	beta-Glucans	51-62	GSL7	Hordeum vulgare	230-234
29089068-0	2017	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by beta-glucan].	beta-Glucans	90-101	guanylate binding protein 2	Mus musculus	1-28
29089068-1	2017	Objective To investigate the effect of guanylate-binding protein 2 (GBP2) on beta-glucan-induced maturation and immune response of dendritic cells (DCs).	beta-Glucans	77-88	guanylate binding protein 2	Mus musculus	39-66
29089068-1	2017	Objective To investigate the effect of guanylate-binding protein 2 (GBP2) on beta-glucan-induced maturation and immune response of dendritic cells (DCs).	beta-Glucans	77-88	guanylate binding protein 2	Mus musculus	68-72
29089068-9	2017	Conclusion GBP2 can effectively regulate beta-glucan-induced maturation of DCs, thus suppressing the proliferation of T cells.	beta-Glucans	41-52	guanylate binding protein 2	Mus musculus	11-15
28810822-11	2017	In conclusion, irradiated beta-glucan modulated signal growth factors, vascular endothelial growth factor A, extracellular signal-regulated kinase 1, and phosphatidylinositol-3-kinase, which contributed to experimental hepatocarcinogenesis.	beta-Glucans	26-37	vascular endothelial growth factor A	Rattus norvegicus	71-107
28810822-11	2017	In conclusion, irradiated beta-glucan modulated signal growth factors, vascular endothelial growth factor A, extracellular signal-regulated kinase 1, and phosphatidylinositol-3-kinase, which contributed to experimental hepatocarcinogenesis.	beta-Glucans	26-37	mitogen activated protein kinase 3	Rattus norvegicus	109-148
28736555-0	2017	beta-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1beta Production.	beta-Glucans	0-11	interleukin 1 beta	Homo sapiens	100-108
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	13-24	interleukin 1 beta	Homo sapiens	178-186
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	13-24	interleukin 6	Homo sapiens	188-192
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	13-24	interleukin 23 subunit alpha	Homo sapiens	198-203
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	124-135	interleukin 1 beta	Homo sapiens	178-186
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	124-135	interleukin 6	Homo sapiens	188-192
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	124-135	interleukin 23 subunit alpha	Homo sapiens	198-203
28634370-4	2017	We demonstrate that B-lymphocytes activated by un-methylated CpG motifs, found in bacterial DNA, and beta-glucans, found in the cell wall of fungi, both induced MMP-7.	beta-Glucans	101-113	matrix metallopeptidase 7	Homo sapiens	161-166
28674449-2	2017	Dectin-1 is a member of the C-type lectin receptor superfamily and was shown to be one of the major receptors for fungal beta-glucans.	beta-Glucans	121-133	C-type lectin domain containing 7A	Homo sapiens	0-8
28674449-5	2017	Stimulation of Dex-DC with beta-glucans induced a strong upregulation of Syk phosphorylation and increased secretion of IL-10, while the production of IL-12, IL-23 and TNF-alpha was reduced.	beta-Glucans	27-39	spleen associated tyrosine kinase	Homo sapiens	73-76
28674449-5	2017	Stimulation of Dex-DC with beta-glucans induced a strong upregulation of Syk phosphorylation and increased secretion of IL-10, while the production of IL-12, IL-23 and TNF-alpha was reduced.	beta-Glucans	27-39	interleukin 10	Homo sapiens	120-125
28674449-5	2017	Stimulation of Dex-DC with beta-glucans induced a strong upregulation of Syk phosphorylation and increased secretion of IL-10, while the production of IL-12, IL-23 and TNF-alpha was reduced.	beta-Glucans	27-39	interleukin 23 subunit alpha	Homo sapiens	158-163
28674449-5	2017	Stimulation of Dex-DC with beta-glucans induced a strong upregulation of Syk phosphorylation and increased secretion of IL-10, while the production of IL-12, IL-23 and TNF-alpha was reduced.	beta-Glucans	27-39	tumor necrosis factor	Homo sapiens	168-177
28530644-5	2017	Using bone marrow chimeric mice, we found that beta-glucan induces liver inflammation via the C-type lectin-like receptor CLEC7A on Kupffer cells and possibly other bone marrow-derived cells.	beta-Glucans	47-58	C-type lectin domain family 7, member a	Mus musculus	122-128
28634370-5	2017	Interestingly, while CpG-stimulated cells activated the mTOR pathway via TLR9 receptor to induced MMP-7, beta-glucan-stimulated cells were mTOR-independent and used Dectin-1 receptor.	beta-Glucans	105-116	mechanistic target of rapamycin kinase	Homo sapiens	139-143
28475968-0	2017	The effect of beta-glucan and its potential analog on the structure of Dectin-1 receptor.	beta-Glucans	14-25	C-type lectin domain containing 7A	Homo sapiens	71-79
28454101-1	2017	Dectin-1 is the critical sensor for beta-glucan from Candida which is the most common human fungal pathogen and cause superficial and system infection.	beta-Glucans	36-47	C-type lectin domain containing 7A	Homo sapiens	0-8
28454101-4	2017	In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway.	beta-Glucans	41-52	interleukin 6	Homo sapiens	141-145
28454101-4	2017	In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway.	beta-Glucans	41-52	tumor necrosis factor	Homo sapiens	150-158
28454101-4	2017	In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway.	beta-Glucans	41-52	C-type lectin domain containing 7A	Homo sapiens	167-175
28454101-4	2017	In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway.	beta-Glucans	41-52	spleen associated tyrosine kinase	Homo sapiens	176-179
28454101-4	2017	In the present study, we found insoluble beta-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFalpha through Dectin-1-Syk-NF-kappaB and p38MAPK pathway.	beta-Glucans	41-52	nuclear factor kappa B subunit 1	Homo sapiens	180-189
28475968-2	2017	The present study, aimed at clarifying effect of BG and a new analog, maltotriose (MT) on Dectin-1 receptor.	beta-Glucans	49-51	C-type lectin domain containing 7A	Homo sapiens	90-98
28279790-10	2017	The In vitro study by using primary spleen cells stimulated with polyI:C revealed a similar expression pattern to that in vivo studies, while the stimulation with beta-glucan or LPS, which normally induced expression of il17d mRNA in target cells in vitro in other animals, did not show apparent changes in the expression of il17d mRNA.	beta-Glucans	163-174	interleukin 17D	Homo sapiens	220-225
28279790-10	2017	The In vitro study by using primary spleen cells stimulated with polyI:C revealed a similar expression pattern to that in vivo studies, while the stimulation with beta-glucan or LPS, which normally induced expression of il17d mRNA in target cells in vitro in other animals, did not show apparent changes in the expression of il17d mRNA.	beta-Glucans	163-174	interleukin 17D	Homo sapiens	325-330
28286256-8	2017	The peak of heat shock protein 70 (HSP70) expression in the 0.2% beta-glucan group was higher and occurred earlier than in other groups (P &lt;= 0.05).	beta-Glucans	65-76	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	12-33
28286256-8	2017	The peak of heat shock protein 70 (HSP70) expression in the 0.2% beta-glucan group was higher and occurred earlier than in other groups (P &lt;= 0.05).	beta-Glucans	65-76	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	35-40
28347513-10	2017	Results are sensitive to oat beta-glucan cost but insensitive to changes in other parameters.	beta-Glucans	29-40	ornithine aminotransferase	Homo sapiens	25-28
28295265-1	2017	Activation of the C-type lectin receptor Dectin-1 by beta-glucans triggers multiple signals within DCs that result in activation of innate immunity.	beta-Glucans	53-65	C-type lectin domain family 7, member a	Mus musculus	41-49
28347513-0	2017	Cost-effectiveness of Maintaining Daily Intake of Oat beta-Glucan for Coronary Heart Disease Primary Prevention.	beta-Glucans	54-65	ornithine aminotransferase	Homo sapiens	50-53
28347513-1	2017	PURPOSE: Oat beta-glucan reduces cholesterol levels and thus reduces the risk for coronary heart disease (CHD).	beta-Glucans	13-24	ornithine aminotransferase	Homo sapiens	9-12
28347513-11	2017	Maintaining &gt;=3 g of oat beta-glucan daily remains cost-effective within plausible range of values.	beta-Glucans	28-39	ornithine aminotransferase	Homo sapiens	24-27
28347513-3	2017	We examined the economic impact of daily intake of &gt;=3 g of oat beta-glucan in primary prevention of CHD in patients receiving statins or no pharmacologic treatment.	beta-Glucans	67-78	ornithine aminotransferase	Homo sapiens	63-66
28154008-2	2017	The fungal pathogen Histoplasma capsulatum minimizes detection of beta-glucan by host cells through at least two mechanisms: concealment of beta-glucans beneath alpha-glucans and enzymatic removal of any exposed beta-glucan polysaccharides by the secreted glucanase Eng1.	beta-Glucans	66-77	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	266-270
27989425-5	2017	In the present study, we investigated mast cell responses to Curdlan, a beta-glucan that acts as an agonist for the fungi receptor Dectin-1, and found a unique response pattern with induced degranulation, but surprisingly without synthesis of Leukotriene C4, IL-6 or CCL2.	beta-Glucans	72-83	C-type lectin domain containing 7A	Homo sapiens	131-139
28154008-3	2017	Histoplasma yeasts also secrete the putative glucanase Exg8, which may serve a similar role as Eng1 in removing exposed beta-glucans from the yeast cell surface.	beta-Glucans	120-132	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	95-99
28154008-10	2017	These results show that Histoplasma yeasts secrete two beta1,3-glucanases and that Eng1 endoglucanase activity is the predominant factor responsible for removal of exposed cell wall beta-glucans to minimize host detection of Histoplasma yeasts.	beta-Glucans	182-194	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	83-87
27987983-7	2017	BALB/c mice that were subcutaneously pre-immunized with three doses of 0.5, 2.5 and 5.0mg of beta-glucan/mouse, showed a significant increase in IL-2, IL-6, IL-10, TNF-alpha and IL-17A production compared to non-immunized mice.	beta-Glucans	93-104	interleukin 2	Mus musculus	145-149
28185642-7	2017	An integrative experimental/theoretical approach allows us to estimate the c/j0-threshold at which human neutrophils first detect nearby beta-glucan surfaces as c/j0   0.0044 s/mum.	beta-Glucans	137-148	latexin	Homo sapiens	177-180
27987983-7	2017	BALB/c mice that were subcutaneously pre-immunized with three doses of 0.5, 2.5 and 5.0mg of beta-glucan/mouse, showed a significant increase in IL-2, IL-6, IL-10, TNF-alpha and IL-17A production compared to non-immunized mice.	beta-Glucans	93-104	interleukin 6	Mus musculus	151-155
27987983-7	2017	BALB/c mice that were subcutaneously pre-immunized with three doses of 0.5, 2.5 and 5.0mg of beta-glucan/mouse, showed a significant increase in IL-2, IL-6, IL-10, TNF-alpha and IL-17A production compared to non-immunized mice.	beta-Glucans	93-104	interleukin 10	Mus musculus	157-162
27987983-7	2017	BALB/c mice that were subcutaneously pre-immunized with three doses of 0.5, 2.5 and 5.0mg of beta-glucan/mouse, showed a significant increase in IL-2, IL-6, IL-10, TNF-alpha and IL-17A production compared to non-immunized mice.	beta-Glucans	93-104	tumor necrosis factor	Mus musculus	164-173
27987983-7	2017	BALB/c mice that were subcutaneously pre-immunized with three doses of 0.5, 2.5 and 5.0mg of beta-glucan/mouse, showed a significant increase in IL-2, IL-6, IL-10, TNF-alpha and IL-17A production compared to non-immunized mice.	beta-Glucans	93-104	interleukin 17A	Mus musculus	178-184
27852745-2	2017	Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component beta-glucan, as well as some component(s) in house dust mite (HDM) extract.	beta-Glucans	99-110	C-type lectin domain family 7, member a	Mus musculus	0-8
28194264-6	2017	RESULTS: NK cell activity and the serum levels of IL-10 were significantly higher from baseline to week 8 in the beta-glucan group compared with the placebo group (P = 0.048, P = 0.029).	beta-Glucans	113-124	interleukin 10	Homo sapiens	50-55
27814595-3	2017	Particulate beta-glucan has been specifically shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS).	beta-Glucans	12-23	cytochrome b-245, beta polypeptide	Mus musculus	130-183
27814595-3	2017	Particulate beta-glucan has been specifically shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS).	beta-Glucans	12-23	cytochrome b-245, beta polypeptide	Mus musculus	185-190
27852745-2	2017	Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component beta-glucan, as well as some component(s) in house dust mite (HDM) extract.	beta-Glucans	99-110	C-type lectin domain family 7, member a	Mus musculus	22-28
27872213-0	2017	Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal beta-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation.	beta-Glucans	73-85	CD8a molecule	Homo sapiens	117-120
27872213-3	2017	A recent study demonstrated that bacterial and fungal beta-glucans stimulate IFN-beta production by dendritic cells (DCs) following detection by the Dectin-1 receptor, but the effects of beta-glucan-induced type I IFNs have not been defined.	beta-Glucans	54-66	interferon beta 1	Homo sapiens	77-85
27872213-3	2017	A recent study demonstrated that bacterial and fungal beta-glucans stimulate IFN-beta production by dendritic cells (DCs) following detection by the Dectin-1 receptor, but the effects of beta-glucan-induced type I IFNs have not been defined.	beta-Glucans	54-65	interferon beta 1	Homo sapiens	77-85
27872213-4	2017	We investigated whether type I IFNs regulate CD8 T cell activation by fungal beta-glucan particle-stimulated DCs.	beta-Glucans	77-88	CD8a molecule	Homo sapiens	45-48
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	CD8a molecule	Homo sapiens	54-57
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	CD44 molecule (Indian blood group)	Homo sapiens	99-103
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	CD69 molecule	Homo sapiens	108-112
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	interferon gamma	Homo sapiens	144-153
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	interleukin 2	Homo sapiens	155-159
27872213-5	2017	We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B.	beta-Glucans	20-31	granzyme B	Homo sapiens	165-175
27872213-6	2017	Moreover, we show that type I IFNs support robust CD8 T cell activation (proliferation and IFN-gamma and granzyme B production) by beta-glucan-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs.	beta-Glucans	131-142	CD8a molecule	Homo sapiens	50-53
27872213-6	2017	Moreover, we show that type I IFNs support robust CD8 T cell activation (proliferation and IFN-gamma and granzyme B production) by beta-glucan-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs.	beta-Glucans	131-142	interferon gamma	Homo sapiens	91-100
29345558-4	2017	beta-glucans from mushrooms modulate the immune system by binding with the dectin-1 receptor on macrophages.	beta-Glucans	0-12	C-type lectin domain family 7, member a	Mus musculus	75-83
27872213-6	2017	Moreover, we show that type I IFNs support robust CD8 T cell activation (proliferation and IFN-gamma and granzyme B production) by beta-glucan-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs.	beta-Glucans	131-142	granzyme B	Homo sapiens	105-115
27872213-7	2017	Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs.	beta-Glucans	158-169	CD86 molecule	Homo sapiens	70-74
29345558-5	2017	Dectin-1 functions as a pattern recognition receptor that recognizes the pathogen-associated molecular pattern of beta-glucans.	beta-Glucans	114-126	C-type lectin domain family 7, member a	Mus musculus	0-8
27872213-7	2017	Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs.	beta-Glucans	158-169	CD40 molecule	Homo sapiens	79-83
27872213-7	2017	Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs.	beta-Glucans	158-169	interleukin 2	Homo sapiens	129-133
27872213-7	2017	Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs.	beta-Glucans	158-169	interleukin 6	Homo sapiens	135-139
27872213-7	2017	Specifically, type I IFNs promote Ag presentation on MHC I molecules, CD86 and CD40 expression, and the production of IL-12 p70, IL-2, IL-6, and TNF-alpha by beta-glucan-stimulated DCs.	beta-Glucans	158-169	tumor necrosis factor	Homo sapiens	145-154
27180103-0	2016	beta-glucan attenuated scopolamine induced cognitive impairment via hippocampal acetylcholinesterase inhibition in rats.	beta-Glucans	0-11	acetylcholinesterase	Rattus norvegicus	80-100
27375187-0	2016	Dietary beta-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish.	beta-Glucans	8-19	complement C3a, tandem duplicate 1	Danio rerio	45-80
27375187-2	2016	Here we clearly demonstrated that beta-glucan enhanced the contents of immune-relevant molecules C3 and Bf in eggs of zebrafish, and the embryos derived from beta-1,3 glucan-treated zebrafish were more resistant to bacterial challenge than control embryos.	beta-Glucans	34-45	integrin, beta 1b.1	Danio rerio	158-166
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	myeloperoxidase	Mus musculus	106-121
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	myeloperoxidase	Mus musculus	123-126
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	nitric oxide synthase 2, inducible	Mus musculus	159-163
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	tumor necrosis factor	Mus musculus	198-207
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	interleukin 1 beta	Mus musculus	209-217
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	interleukin 6	Mus musculus	222-226
27358258-0	2016	Particulate beta-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells.	beta-Glucans	12-24	toll like receptor 4	Homo sapiens	50-54
27358258-0	2016	Particulate beta-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells.	beta-Glucans	12-24	C-type lectin domain containing 7A	Homo sapiens	59-67
27358258-2	2016	Particulate beta-glucans induce stronger immune responses than soluble beta-glucans by clustering of Dectin-1 receptors.	beta-Glucans	12-24	C-type lectin domain containing 7A	Homo sapiens	101-109
27358258-2	2016	Particulate beta-glucans induce stronger immune responses than soluble beta-glucans by clustering of Dectin-1 receptors.	beta-Glucans	71-83	C-type lectin domain containing 7A	Homo sapiens	101-109
27358258-3	2016	Here, it was hypothesized that activation of other pattern recognition receptors such as Toll-like receptor 4 (TLR4) can also contribute to enhanced activity of immune cells after exposure to particulate beta-glucans.	beta-Glucans	204-216	toll like receptor 4	Homo sapiens	89-109
27358258-3	2016	Here, it was hypothesized that activation of other pattern recognition receptors such as Toll-like receptor 4 (TLR4) can also contribute to enhanced activity of immune cells after exposure to particulate beta-glucans.	beta-Glucans	204-216	toll like receptor 4	Homo sapiens	111-115
27358258-5	2016	Enhanced NF-kappaB activation was observed after stimulation with particulate beta-glucans in both Dectin-1A-TLR4 and the Dectin-1B-TLR4 cell lines.	beta-Glucans	78-90	toll like receptor 4	Homo sapiens	99-113
27358258-5	2016	Enhanced NF-kappaB activation was observed after stimulation with particulate beta-glucans in both Dectin-1A-TLR4 and the Dectin-1B-TLR4 cell lines.	beta-Glucans	78-90	toll like receptor 4	Homo sapiens	109-113
27358258-6	2016	This was different with soluble beta-glucans, which enhanced activation in Dectin-1A-TLR4 cell lines but not in Dectin-1B-TLR4 cells.	beta-Glucans	32-44	toll like receptor 4	Homo sapiens	75-89
27358258-6	2016	This was different with soluble beta-glucans, which enhanced activation in Dectin-1A-TLR4 cell lines but not in Dectin-1B-TLR4 cells.	beta-Glucans	32-44	toll like receptor 4	Homo sapiens	85-89
27358258-7	2016	The synergistic activation of TLR4 and Dectin-1 by particulate beta-glucans was confirmed in human dendritic cells.	beta-Glucans	63-75	toll like receptor 4	Homo sapiens	30-34
27358258-7	2016	The synergistic activation of TLR4 and Dectin-1 by particulate beta-glucans was confirmed in human dendritic cells.	beta-Glucans	63-75	C-type lectin domain containing 7A	Homo sapiens	39-47
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	toll like receptor 4	Homo sapiens	47-51
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	toll like receptor 4	Homo sapiens	88-92
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	interleukin 23 subunit alpha	Homo sapiens	128-133
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	interleukin 4	Homo sapiens	135-139
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	interleukin 6	Homo sapiens	141-145
27358258-8	2016	The effects of particulate beta-glucan induced TLR4 binding were regulatory as blocking TLR4 enhanced pro-inflammatory cytokine IL-23, IL-4, IL-6, and TNF-alpha production.	beta-Glucans	27-38	tumor necrosis factor	Homo sapiens	151-160
27358258-9	2016	CONCLUSION: These results suggest that TLR4 and Dectin-1 are synergistically activated by particulate beta-glucans, wherein TLR4 activates an immune regulatory pathway in human dendritic cells.	beta-Glucans	102-114	toll like receptor 4	Homo sapiens	39-43
27358258-9	2016	CONCLUSION: These results suggest that TLR4 and Dectin-1 are synergistically activated by particulate beta-glucans, wherein TLR4 activates an immune regulatory pathway in human dendritic cells.	beta-Glucans	102-114	C-type lectin domain containing 7A	Homo sapiens	48-56
27358258-10	2016	Our data suggest that beta-glucan is an immune regulatory ligand for TLR4.	beta-Glucans	22-33	toll like receptor 4	Homo sapiens	69-73
27853145-4	2016	Two MARCO heterozygous (AG) genotypes (single-nucleotide polymorphisms rs2278589 and rs6751745) were associated with impaired phagocytosis of M. tuberculosis trehalose 6,6"-dimycolate-cord factor and beta-glucan-coated beads in macrophages.	beta-Glucans	200-211	macrophage receptor with collagenous structure	Homo sapiens	4-9
27747357-0	2016	Oral administration of Lentinus edodes beta-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARgamma pathways.	beta-Glucans	39-51	ELK1, member of ETS oncogene family	Mus musculus	112-117
27747357-0	2016	Oral administration of Lentinus edodes beta-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARgamma pathways.	beta-Glucans	39-51	peroxisome proliferator activated receptor gamma	Mus musculus	127-136
27766108-3	2016	In the present study, the exacerbating effect of the combined exposure to zymosan A (ZymA) containing yeast beta-glucan and heat-inactivated ASD on ovalbumin (OVA)-induced murine lung eosinophilia was investigated.	beta-Glucans	108-119	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	148-157
27052424-5	2016	In conclusion, beta-glucan could alleviate cute hypoxia-induced oxidative stress in large yellow croker by enhancing anaerobic glycolysis capacity, emphasizing a central role of transcription factor HIF-1alpha in the process.	beta-Glucans	15-26	hypoxia-inducible factor 1-alpha	Larimichthys crocea	199-209
27180103-3	2016	Briefly, in-silico analysis revealed promising interactions of beta-glucan with the catalytic residues of acetylcholinesterase (AChE) enzyme.	beta-Glucans	63-74	acetylcholinesterase	Rattus norvegicus	106-126
27180103-3	2016	Briefly, in-silico analysis revealed promising interactions of beta-glucan with the catalytic residues of acetylcholinesterase (AChE) enzyme.	beta-Glucans	63-74	acetylcholinesterase	Rattus norvegicus	128-132
27180103-4	2016	In line with this outcome, the in vitro assay (Ellman"s method) also exhibited inhibition of AChE by beta-glucan (IC50=0.68+-0.08mug/microl).	beta-Glucans	101-112	acetylcholinesterase	Rattus norvegicus	93-97
27180103-8	2016	Hence, it can be deduced that beta-glucan possesses potential to enhance central cholinergic tone via inhibiting AChE enzyme.	beta-Glucans	30-41	acetylcholinesterase	Rattus norvegicus	113-117
26988468-5	2016	Apo-transferrin increased the formation of hydroxyl radicals and this related with a faster degradation of beta-glucan.	beta-Glucans	107-118	transferrin	Homo sapiens	4-15
27822248-10	2016	The five spots that were down-regulated with dietary beta-glucan supplementation were identified as different forms of myosin: myosin light polypeptide 3-2 (spot 3), myosin light chain 1 (spots 4 and 5), fast myosin light chain 2 (spot 6) and myosin heavy chain (spot 7).	beta-Glucans	53-64	myosin light chain 1, skeletal muscle isoform	Oncorhynchus mykiss	166-186
26948614-4	2016	Copper ions induced viscosity increase of the AX-solutions and form stronger thermoreversible gels with increasing ion-concentration; optimal gelation was at 15  C. For added beta-glucan at levels &gt;1%, the lower the concentration and the higher the molecular weight of beta-glucan, the weaker the gelling ability of the mixed AX/BG system treated with peroxidase/H2O2.	beta-Glucans	175-186	peroxidase-like	Triticum aestivum	355-365
27822248-10	2016	The five spots that were down-regulated with dietary beta-glucan supplementation were identified as different forms of myosin: myosin light polypeptide 3-2 (spot 3), myosin light chain 1 (spots 4 and 5), fast myosin light chain 2 (spot 6) and myosin heavy chain (spot 7).	beta-Glucans	53-64	fast myosin light chain 2	Oncorhynchus mykiss	204-229
27822248-10	2016	The five spots that were down-regulated with dietary beta-glucan supplementation were identified as different forms of myosin: myosin light polypeptide 3-2 (spot 3), myosin light chain 1 (spots 4 and 5), fast myosin light chain 2 (spot 6) and myosin heavy chain (spot 7).	beta-Glucans	53-64	myosin-6	Oncorhynchus mykiss	243-261
27306059-2	2016	Dectin-1 recognizes beta-glucans and mediates innate immune responses to Aspergillus fumigatus.	beta-Glucans	20-32	C-type lectin domain containing 7A	Homo sapiens	0-8
27390655-0	2016	Orally administered beta-glucan attenuates the Th2 response in a model of airway hypersensitivity.	beta-Glucans	20-31	heart and neural crest derivatives expressed 2	Mus musculus	47-50
26773960-4	2016	Treatment with beta-glucan drastically decreased the levels of regulatory T (Treg) cells but increased the infiltration of macrophages, granulocytes and DCs in tumor masses, thus elicited Th1 differentiation and cytotoxic T-lymphocyte responses and led to a delay in tumor progression.	beta-Glucans	15-26	negative elongation factor complex member C/D	Homo sapiens	188-191
26773960-6	2016	beta-Glucan directly abrogated tumor-educated dendritic cells-associated immune suppression, promoted Th1 differentiation and cytotoxic T-lymphocyte priming and improved antitumor responses.	beta-Glucans	0-11	negative elongation factor complex member C/D	Homo sapiens	102-105
27121946-0	2016	Tetrandrine suppresses beta-glucan-induced macrophage activation via inhibiting NF-kappaB, ERK and STAT3 signaling pathways.	beta-Glucans	23-34	mitogen-activated protein kinase 1	Homo sapiens	91-94
27094334-0	2016	The Eng1 beta-Glucanase Enhances Histoplasma Virulence by Reducing beta-Glucan Exposure.	beta-Glucans	9-20	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	4-8
27188900-0	2016	Oat beta-glucan depresses SGLT1- and GLUT2-mediated glucose transport in intestinal epithelial cells (IEC-6).	beta-Glucans	4-15	solute carrier family 5 member 1	Homo sapiens	26-31
27188900-0	2016	Oat beta-glucan depresses SGLT1- and GLUT2-mediated glucose transport in intestinal epithelial cells (IEC-6).	beta-Glucans	4-15	solute carrier family 2 member 2	Homo sapiens	37-42
27188900-7	2016	The suppression of glucose uptake and SGLT1 and GLUT2 expression by increasing concentrations (4-8 mg/mL) of oat beta-glucan demonstrated a direct effect of the physical properties of oat beta-glucan on glucose transport.	beta-Glucans	113-124	solute carrier family 5 member 1	Homo sapiens	38-43
27188900-7	2016	The suppression of glucose uptake and SGLT1 and GLUT2 expression by increasing concentrations (4-8 mg/mL) of oat beta-glucan demonstrated a direct effect of the physical properties of oat beta-glucan on glucose transport.	beta-Glucans	113-124	solute carrier family 2 member 2	Homo sapiens	48-53
27188900-7	2016	The suppression of glucose uptake and SGLT1 and GLUT2 expression by increasing concentrations (4-8 mg/mL) of oat beta-glucan demonstrated a direct effect of the physical properties of oat beta-glucan on glucose transport.	beta-Glucans	188-199	solute carrier family 5 member 1	Homo sapiens	38-43
27188900-7	2016	The suppression of glucose uptake and SGLT1 and GLUT2 expression by increasing concentrations (4-8 mg/mL) of oat beta-glucan demonstrated a direct effect of the physical properties of oat beta-glucan on glucose transport.	beta-Glucans	188-199	solute carrier family 2 member 2	Homo sapiens	48-53
27121946-0	2016	Tetrandrine suppresses beta-glucan-induced macrophage activation via inhibiting NF-kappaB, ERK and STAT3 signaling pathways.	beta-Glucans	23-34	signal transducer and activator of transcription 3	Homo sapiens	99-104
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	tumor necrosis factor	Homo sapiens	127-154
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	tumor necrosis factor	Homo sapiens	156-165
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	interleukin 1 beta	Homo sapiens	171-189
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	interleukin 1 beta	Homo sapiens	191-199
27183653-0	2016	Correction: Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.	beta-Glucans	53-64	C-type lectin domain containing 7A	Homo sapiens	12-20
27118584-3	2016	One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye"s group presented data showing that yeasts of this organism secrete a beta-glucanase, Eng1, which acts to prune beta-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15].	beta-Glucans	199-211	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	173-177
27094334-6	2016	Histoplasma yeasts deficient for Eng1 show increased exposure of cell wall beta-glucans, which results in enhanced binding to the Dectin-1 beta-glucan receptor.	beta-Glucans	75-87	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	33-37
27094334-8	2016	While not responsible for large-scale cell wall structure and function, the secreted Eng1 reduces levels of exposed beta-glucans at the yeast cell wall, thereby diminishing potential recognition by Dectin-1 and proinflammatory cytokine production by phagocytes.	beta-Glucans	116-128	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	85-89
27094334-9	2016	In alpha-glucan-producing Histoplasma strains, Eng1 acts in concert with alpha-glucan to minimize beta-glucan exposure: alpha-glucan provides a masking function by covering the beta-glucan-rich cell wall, while Eng1 removes any remaining exposed beta-glucans.	beta-Glucans	98-109	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	47-51
27094334-9	2016	In alpha-glucan-producing Histoplasma strains, Eng1 acts in concert with alpha-glucan to minimize beta-glucan exposure: alpha-glucan provides a masking function by covering the beta-glucan-rich cell wall, while Eng1 removes any remaining exposed beta-glucans.	beta-Glucans	177-188	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	47-51
27094334-9	2016	In alpha-glucan-producing Histoplasma strains, Eng1 acts in concert with alpha-glucan to minimize beta-glucan exposure: alpha-glucan provides a masking function by covering the beta-glucan-rich cell wall, while Eng1 removes any remaining exposed beta-glucans.	beta-Glucans	246-258	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	47-51
27094334-10	2016	Thus, Histoplasma Eng1 has evolved a specialized pathogenesis function to remove exposed beta-glucans, thereby enhancing the ability of yeasts to escape detection by host phagocytes.	beta-Glucans	89-101	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	18-22
27094334-12	2016	In this study, we showed that Histoplasma pathogenic yeast cells, but not avirulent mycelia, secrete a beta-glucanase, Eng1, which reduces recognition of fungal cell wall beta-glucans.	beta-Glucans	171-183	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	119-123
27094334-13	2016	We demonstrated that the Eng1 beta-glucanase promotes Histoplasma virulence by reducing levels of surface-exposed beta-glucans on yeast cells, thereby enabling Histoplasma yeasts to escape detection by the host beta-glucan receptor, Dectin-1.	beta-Glucans	114-126	endo-1,3(4)-beta-glucanase	Saccharomyces cerevisiae S288C	25-29
26882889-10	2016	Also, the TLR4 ligand LPS and TLR2 ligand like beta-glucan may be strong candidates for exacerbation of lung eosinophilia.	beta-Glucans	47-58	toll-like receptor 4	Mus musculus	10-14
27057204-0	2016	beta-glucans: ex vivo inflammatory and oxidative stress results after pasta intake.	beta-Glucans	0-12	solute carrier family 45 member 1	Homo sapiens	70-75
27057204-3	2016	Thus, in our study, we considered fibers like beta-glucans that have been added to pasta with a percentage of 6 %.	beta-Glucans	46-58	solute carrier family 45 member 1	Homo sapiens	83-88
26762386-1	2016	Dectin-1, a C-type lectin receptor that recognizes fungal beta-glucans, is involved in antifungal immunity and the regulation of intestinal immune homeostasis.	beta-Glucans	58-70	C-type lectin domain containing 7A	Sus scrofa	0-8
26936139-0	2016	High-Molecular-Weight beta-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults.	beta-Glucans	22-33	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	90-96
26936139-9	2016	This effect of HMW beta-glucan was associated with gene-diet interaction, whereby individuals with the single nucleotide polymorphism (SNP) rs3808607-G allele (GG or GT) of the cytochrome P450 family 7 subfamily A member 1 gene (CYP7A1) had greater responses to 3 g HMW beta-glucan/d in lowering TC than TT carriers (P= 0.0006).	beta-Glucans	19-30	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	177-222
26936139-9	2016	This effect of HMW beta-glucan was associated with gene-diet interaction, whereby individuals with the single nucleotide polymorphism (SNP) rs3808607-G allele (GG or GT) of the cytochrome P450 family 7 subfamily A member 1 gene (CYP7A1) had greater responses to 3 g HMW beta-glucan/d in lowering TC than TT carriers (P= 0.0006).	beta-Glucans	19-30	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	229-235
26936139-9	2016	This effect of HMW beta-glucan was associated with gene-diet interaction, whereby individuals with the single nucleotide polymorphism (SNP) rs3808607-G allele (GG or GT) of the cytochrome P450 family 7 subfamily A member 1 gene (CYP7A1) had greater responses to 3 g HMW beta-glucan/d in lowering TC than TT carriers (P= 0.0006).	beta-Glucans	270-281	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	177-222
26938503-8	2016	FH alone did not trigger the cells to produce neutrophil extracellular traps (NETs), but NET formation induced by PMA and by fibronectin plus fungal beta-glucan were inhibited by immobilized, but not by soluble, FH.	beta-Glucans	149-160	complement factor H	Homo sapiens	0-2
26938503-9	2016	Moreover, in parallel with NET formation, immobilized FH also inhibited the production of reactive oxygen species induced by PMA and by fibronectin plus beta-glucan.	beta-Glucans	153-164	complement factor H	Homo sapiens	54-56
26882889-10	2016	Also, the TLR4 ligand LPS and TLR2 ligand like beta-glucan may be strong candidates for exacerbation of lung eosinophilia.	beta-Glucans	47-58	toll-like receptor 2	Mus musculus	30-34
26573878-3	2016	We show that human monocyte derived DC (mDC) secretion of TSLP in response to Candida albicans and beta-glucans requires dectin-1, Syk, NF-kappaB, and p38 MAPK signaling.	beta-Glucans	99-111	chemokine (C-C motif) ligand 22	Mus musculus	36-38
27624963-3	2016	beta-Glucans have a conserved beta-1,3-glucan backbone with sporadic beta-1,3- or beta-1,6-linked short glucans as branches at the 6-O-positions, and the branches may play a critical role in their immunologic functions.	beta-Glucans	0-12	hemoglobin, beta adult major chain	Mus musculus	30-38
27624963-3	2016	beta-Glucans have a conserved beta-1,3-glucan backbone with sporadic beta-1,3- or beta-1,6-linked short glucans as branches at the 6-O-positions, and the branches may play a critical role in their immunologic functions.	beta-Glucans	0-12	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	69-77
26828762-2	2016	Dectin-1 is essential for antifungal immune responses, recognizing the fungal cellular component beta-glucan, and its role as a PRR has been of increasing interest.	beta-Glucans	97-108	C-type lectin domain containing 7A	Homo sapiens	0-8
26810222-3	2016	Yeast-derived whole beta-glucan particles (WGP; a ligand to engage and activate dectin-1, oral treatment in vivo) significantly decreased tumor weight and splenomegaly in tumor-bearing mice with reduced accumulation of polymorphonuclear MDSC but not monocytic MDSC (M-MDSC), and decreased polymorphonuclear MDSC suppression in vitro through the induction of respiratory burst and apoptosis.	beta-Glucans	20-31	C-type lectin domain containing 7A	Homo sapiens	80-88
26573878-3	2016	We show that human monocyte derived DC (mDC) secretion of TSLP in response to Candida albicans and beta-glucans requires dectin-1, Syk, NF-kappaB, and p38 MAPK signaling.	beta-Glucans	99-111	chemokine (C-C motif) ligand 22	Mus musculus	40-43
26573878-3	2016	We show that human monocyte derived DC (mDC) secretion of TSLP in response to Candida albicans and beta-glucans requires dectin-1, Syk, NF-kappaB, and p38 MAPK signaling.	beta-Glucans	99-111	thymic stromal lymphopoietin	Homo sapiens	58-62
26573878-3	2016	We show that human monocyte derived DC (mDC) secretion of TSLP in response to Candida albicans and beta-glucans requires dectin-1, Syk, NF-kappaB, and p38 MAPK signaling.	beta-Glucans	99-111	C-type lectin domain containing 7A	Homo sapiens	121-129
26485047-0	2015	beta-glucan microparticles targeted to epithelial APN as oral antigen delivery system.	beta-Glucans	0-11	alanyl aminopeptidase, membrane	Homo sapiens	50-53
26749442-3	2016	Accordingly, beta-glucan surface exposure during Aspergillus fumigatus germination activates an Atg5-dependent autophagy pathway termed LC3-associated phagocytosis (LAP), which promotes fungal killing.	beta-Glucans	13-24	autophagy related 5	Mus musculus	96-100
26708010-0	2016	Arabinogalactan:beta-glucan as novel biodegradable carriers for recombinant human thrombin.	beta-Glucans	16-27	coagulation factor II, thrombin	Homo sapiens	82-90
26728370-7	2016	RESULTS: Compared with the control group, the expressions of co-stimulation molecules (MHC II, CD40, CD80, CD86) on BMDCs were up-regulated in the presence of beta-glucan.	beta-Glucans	159-170	histocompatibility-2, MHC	Mus musculus	87-93
26728370-7	2016	RESULTS: Compared with the control group, the expressions of co-stimulation molecules (MHC II, CD40, CD80, CD86) on BMDCs were up-regulated in the presence of beta-glucan.	beta-Glucans	159-170	CD40 antigen	Mus musculus	95-99
26728370-7	2016	RESULTS: Compared with the control group, the expressions of co-stimulation molecules (MHC II, CD40, CD80, CD86) on BMDCs were up-regulated in the presence of beta-glucan.	beta-Glucans	159-170	CD80 antigen	Mus musculus	101-105
26728370-7	2016	RESULTS: Compared with the control group, the expressions of co-stimulation molecules (MHC II, CD40, CD80, CD86) on BMDCs were up-regulated in the presence of beta-glucan.	beta-Glucans	159-170	CD86 antigen	Mus musculus	107-111
26728370-8	2016	Furthermore, beta-glucan could prompt BMDCs to secret high levels of IL-6, TNF-alpha, IL-12 p40 and increase the production of CCR7 mRNA.	beta-Glucans	13-24	interleukin 6	Mus musculus	69-73
26728370-8	2016	Furthermore, beta-glucan could prompt BMDCs to secret high levels of IL-6, TNF-alpha, IL-12 p40 and increase the production of CCR7 mRNA.	beta-Glucans	13-24	tumor necrosis factor	Mus musculus	75-84
26728370-8	2016	Furthermore, beta-glucan could prompt BMDCs to secret high levels of IL-6, TNF-alpha, IL-12 p40 and increase the production of CCR7 mRNA.	beta-Glucans	13-24	interleukin 12b	Mus musculus	86-95
26728370-8	2016	Furthermore, beta-glucan could prompt BMDCs to secret high levels of IL-6, TNF-alpha, IL-12 p40 and increase the production of CCR7 mRNA.	beta-Glucans	13-24	chemokine (C-C motif) receptor 7	Mus musculus	127-131
26728370-9	2016	After beta-glucan treatment, BMDCs were more sensitive to CCL19/CCL21.	beta-Glucans	6-17	chemokine (C-C motif) ligand 19	Mus musculus	58-63
26394716-0	2016	Arabinoxylan activates Dectin-1 and modulates particulate beta-glucan-induced Dectin-1 activation.	beta-Glucans	58-69	C-type lectin domain containing 7A	Homo sapiens	78-86
26394716-5	2016	Soluble beta-glucans are known to inhibit the particulate beta-glucan-induced activation of Dectin-1.	beta-Glucans	8-20	C-type lectin domain containing 7A	Homo sapiens	92-100
26394716-5	2016	Soluble beta-glucans are known to inhibit the particulate beta-glucan-induced activation of Dectin-1.	beta-Glucans	8-19	C-type lectin domain containing 7A	Homo sapiens	92-100
26394716-9	2016	The production of the antifungal cytokines IL-4 and IL-23 were increased in dendritic cells stimulated with arabinoxylan and particulate beta-glucan.	beta-Glucans	137-148	interleukin 4	Homo sapiens	43-47
26394716-9	2016	The production of the antifungal cytokines IL-4 and IL-23 were increased in dendritic cells stimulated with arabinoxylan and particulate beta-glucan.	beta-Glucans	137-148	interleukin 23 subunit alpha	Homo sapiens	52-57
26432866-3	2015	beta-Glucans are a diverse group of polysaccharides previously suggested to serve as fungal ligands for SP-D.	beta-Glucans	0-12	surfactant associated protein D	Mus musculus	104-108
25461401-10	2015	Interestingly, the IL-1Ra synthesis induced by beta-glucan was blocked by inhibitors of the Akt/PI3K pathway.	beta-Glucans	47-58	interleukin 1 receptor antagonist	Homo sapiens	19-25
26497456-3	2016	Although Rim15p is required for the synthesis of trehalose and glycogen from UDPG upon entry of cells into the quiescent state, we found that Rim15p is also essential for the accumulation of cell wall beta-glucans, which are also anabolic products of UDPG.	beta-Glucans	201-213	protein kinase RIM15	Saccharomyces cerevisiae S288C	142-148
26497456-7	2016	Consistent with this, sake yeast strains with defective Rim15p exhibited impaired expression of PGM2 and UGP1 and decreased levels of beta-glucans, trehalose, and glycogen during sake fermentation.	beta-Glucans	134-146	protein kinase RIM15	Saccharomyces cerevisiae S288C	56-62
26129870-4	2015	Carboxymethylated beta-glucan administration to hyperlipidemic mice significantly (p&lt;0.05) increased the serum concentration of cystatin C, but significantly (p&lt;0.01) decreased chitotriosidase activity, when each was compared to mice treated with poloxamer 407 only.	beta-Glucans	18-29	cystatin C	Mus musculus	131-141
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	beta-Glucans	188-200	C-type lectin domain family 18 member A	Homo sapiens	14-21
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	beta-Glucans	188-200	C-type lectin domain family 18 member A	Homo sapiens	35-42
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	beta-Glucans	188-200	C-type lectin domain family 18 member A	Homo sapiens	35-42
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	beta-Glucans	188-200	C-type lectin domain family 18 member A	Homo sapiens	14-20
26291983-7	2015	Furthermore, treatment with beta-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p &lt; 0.05).	beta-Glucans	28-40	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	67-139
26291983-7	2015	Furthermore, treatment with beta-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p &lt; 0.05).	beta-Glucans	28-40	TNF receptor superfamily member 11B	Rattus norvegicus	154-169
26123355-6	2015	Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to beta-glucan.	beta-Glucans	171-182	TNF superfamily member 4	Homo sapiens	139-144
26405609-0	2015	Particulate beta-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression.	beta-Glucans	12-23	nuclear factor I/A	Mus musculus	119-123
25875639-0	2015	Stimulation of macrophages with the beta-glucan produced by aureobasidium pullulans promotes the secretion of tumor necrosis factor-related apoptosis inducing ligand (TRAIL).	beta-Glucans	36-47	TNF superfamily member 10	Homo sapiens	167-172
25875639-7	2015	The induction activity of TRAIL by curdlan, a bacterial beta-glucan, was very similar to that by AP-PG in RAW264.7 cells, but weaker in macrophage-differentiated THP-1 cells.	beta-Glucans	56-67	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	26-31
25636576-0	2015	beta-Glucan enhances cytotoxic T lymphocyte responses by activation of human monocyte-derived dendritic cells via the PI3K/AKT pathway.	beta-Glucans	0-11	AKT serine/threonine kinase 1	Homo sapiens	123-126
25461401-5	2015	RESULTS: C. albicans induced a strong IL-1Ra response, and this induction was primarily induced by the cell-wall component beta-glucan.	beta-Glucans	123-134	interleukin 1 receptor antagonist	Homo sapiens	38-44
26453753-0	2015	Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.	beta-Glucans	41-52	C-type lectin domain family 7, member a	Mus musculus	0-8
26453753-4	2015	In addition, particulate beta-glucan converts immunosuppressive TAM via the C-type lectin receptor dectin-1-induced spleen tyrosine kinase-Card9-Erk pathway.	beta-Glucans	25-36	C-type lectin domain family 7, member a	Mus musculus	99-107
26453753-4	2015	In addition, particulate beta-glucan converts immunosuppressive TAM via the C-type lectin receptor dectin-1-induced spleen tyrosine kinase-Card9-Erk pathway.	beta-Glucans	25-36	caspase recruitment domain family, member 9	Mus musculus	139-144
26453753-4	2015	In addition, particulate beta-glucan converts immunosuppressive TAM via the C-type lectin receptor dectin-1-induced spleen tyrosine kinase-Card9-Erk pathway.	beta-Glucans	25-36	Eph receptor B2	Mus musculus	145-148
26562838-3	2015	Time lapse confocal imaging indicated that Dectin-1, the C-type lectin receptor that recognizes Candida albicans cell wall-associated beta-glucan, is recruited to lipid rafts upon Candida albicans uptake by monocytes, supporting the notion that lipid rafts act as an entry platform.	beta-Glucans	134-145	C-type lectin domain containing 7A	Homo sapiens	43-51
26549577-0	2015	Microparticulate beta-glucan vaccine conjugates phagocytized by dendritic cells activate both naive CD4 and CD8 T cells in vitro.	beta-Glucans	17-28	CD4 molecule	Homo sapiens	100-103
26549577-0	2015	Microparticulate beta-glucan vaccine conjugates phagocytized by dendritic cells activate both naive CD4 and CD8 T cells in vitro.	beta-Glucans	17-28	CD8a molecule	Homo sapiens	108-111
26597205-8	2015	We have discovered that both BCG (via NOD2 signalling) and beta-glucan (via dectin-1) induce epigenetic reprogramming, in particular stable changes in histone trimethylation at H3K4.	beta-Glucans	59-70	C-type lectin domain containing 7A	Homo sapiens	76-84
26255117-0	2015	Antiproliferative and pro-apoptotic effects of three fungal exocellular beta-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a.	beta-Glucans	72-84	forkhead box O3	Homo sapiens	222-228
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	tumor protein p53	Homo sapiens	93-96
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	interferon alpha inducible protein 27	Homo sapiens	98-101
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	forkhead box O3	Homo sapiens	187-193
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	BCL2 associated X, apoptosis regulator	Homo sapiens	195-198
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	caspase 3	Homo sapiens	203-212
26255117-7	2015	Exposure to beta-glucans increased apoptosis, necrosis, oxidative stress, mRNA expression of p53, p27 and Bax; the activity of AMP-activated protein-kinase, Forkhead transcription factor FOXO3a, Bax and caspase-3; and decreased the activity of p70S6K in MCF-7 cells.	beta-Glucans	12-24	ribosomal protein S6 kinase B1	Homo sapiens	244-250
26255117-10	2015	This study demonstrated for the first time that the apoptosis induced by beta-glucans was mediated by AMP-activated protein-kinase and Forkhead transcription factor, FOXO3a.	beta-Glucans	73-85	forkhead box O3	Homo sapiens	166-172
26388856-1	2015	Dectin-1 is a pattern recognition receptor (PRR) that recognizes beta-glucans and plays a major role in the immunity against fungal pathogens.	beta-Glucans	65-77	C-type lectin domain family 7, member a	Mus musculus	0-8
25297926-1	2015	The protein product of Saccharomyces cerevisiae DFG5 gene is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane protein and a putative glycosidase/glycosyltransferase that links other GPI-anchored proteins to beta-glucans in the cell wall.	beta-Glucans	220-232	putative mannan endo-1,6-alpha-mannosidase	Saccharomyces cerevisiae S288C	48-52
26010124-0	2015	Effect of beta-glucan on MUC4 and MUC5B expression in human airway epithelial cells.	beta-Glucans	10-21	mucin 4, cell surface associated	Homo sapiens	25-29
26010124-0	2015	Effect of beta-glucan on MUC4 and MUC5B expression in human airway epithelial cells.	beta-Glucans	10-21	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	34-39
26010124-4	2015	Therefore, in this study, the effect and signaling pathway of beta-glucan on mucins MUC4 and MUC5B were investigated in human airway epithelial cells.	beta-Glucans	62-73	mucin 4, cell surface associated	Homo sapiens	84-88
26010124-4	2015	Therefore, in this study, the effect and signaling pathway of beta-glucan on mucins MUC4 and MUC5B were investigated in human airway epithelial cells.	beta-Glucans	62-73	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	93-98
26010124-5	2015	METHODS: In NCI-H292 cells and human normal nasal epithelial cells, the effect and signaling pathway of beta-glucan on MUC4 and MUC5B expression were investigated using reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, enzyme immunoassay, and immunoblot analysis with specific inhibitors and small interfering RNA (siRNA).	beta-Glucans	104-115	mucin 4, cell surface associated	Homo sapiens	119-123
26010124-5	2015	METHODS: In NCI-H292 cells and human normal nasal epithelial cells, the effect and signaling pathway of beta-glucan on MUC4 and MUC5B expression were investigated using reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, enzyme immunoassay, and immunoblot analysis with specific inhibitors and small interfering RNA (siRNA).	beta-Glucans	104-115	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	128-133
26010124-6	2015	RESULTS: beta-Glucan increased MUC4 and MUC5B expression and activated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	beta-Glucans	9-20	mucin 4, cell surface associated	Homo sapiens	31-35
26010124-6	2015	RESULTS: beta-Glucan increased MUC4 and MUC5B expression and activated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	beta-Glucans	9-20	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	40-45
26010124-6	2015	RESULTS: beta-Glucan increased MUC4 and MUC5B expression and activated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	beta-Glucans	9-20	mitogen-activated protein kinase 14	Homo sapiens	94-130
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	beta-Glucans	104-115	mucin 4, cell surface associated	Homo sapiens	124-128
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	beta-Glucans	104-115	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	133-138
25977381-0	2015	beta-Glucan from Saccharomyces cerevisiae Induces IFN-gamma Production In Vivo in BALB/c Mice.	beta-Glucans	0-11	interferon gamma	Mus musculus	50-59
25977381-5	2015	The aim of the experiments was to investigate how different Saccharomyces cerevisiae beta-glucan preparations with different molecular size affect interferon-gamma (IFN-gamma) production in BALB/c mice.	beta-Glucans	85-96	interferon gamma	Mus musculus	147-163
25977381-5	2015	The aim of the experiments was to investigate how different Saccharomyces cerevisiae beta-glucan preparations with different molecular size affect interferon-gamma (IFN-gamma) production in BALB/c mice.	beta-Glucans	85-96	interferon gamma	Mus musculus	165-174
25977381-9	2015	RESULTS: The results showed that orally-administered beta-glucan from S. cerevisiae enhanced IFN-gamma production in BALB/c mice in the in vivo model, but not by mouse leukocytes in vitro.	beta-Glucans	53-64	interferon gamma	Mus musculus	93-102
25977381-10	2015	Moreover, water-soluble beta-glucan enhanced IFN-gamma production more effectively than did particulate beta-glucan.	beta-Glucans	24-35	interferon gamma	Mus musculus	45-54
25977381-12	2015	Our experiments have shown that beta-glucan preparations enhance IFN-gamma production in BALB/c mice and can be potentially used for immune system stimulation in mammals.	beta-Glucans	32-43	interferon gamma	Mus musculus	65-74
25510899-0	2015	The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound beta-glucan.	beta-Glucans	120-131	toll-like receptor 2	Mus musculus	4-8
25510899-6	2015	Rapid centrifugation of PSK can separate the fraction with TLR2 agonist activity from the soluble beta-glucan fraction.	beta-Glucans	98-109	TAO kinase 2	Mus musculus	24-27
25510899-8	2015	Uptake of the labeled beta-glucan by J774A macrophages and JAWSII dendritic cells was inhibited by anti-Dectin-1 antibody but not by anti-TLR2 antibody, confirming that Dectin-1 is the receptor for beta-glucan.	beta-Glucans	22-33	C-type lectin domain family 7, member a	Mus musculus	104-112
25510899-8	2015	Uptake of the labeled beta-glucan by J774A macrophages and JAWSII dendritic cells was inhibited by anti-Dectin-1 antibody but not by anti-TLR2 antibody, confirming that Dectin-1 is the receptor for beta-glucan.	beta-Glucans	22-33	C-type lectin domain family 7, member a	Mus musculus	169-177
25510899-8	2015	Uptake of the labeled beta-glucan by J774A macrophages and JAWSII dendritic cells was inhibited by anti-Dectin-1 antibody but not by anti-TLR2 antibody, confirming that Dectin-1 is the receptor for beta-glucan.	beta-Glucans	198-209	C-type lectin domain family 7, member a	Mus musculus	169-177
25510899-9	2015	Interestingly, pre-treatment of JAWSII cells with the TLR2-active lipid fraction significantly enhanced the uptake of the soluble beta-glucan, indicating the synergy between the TLR2 agonist component and the beta-glucan component.	beta-Glucans	130-141	toll-like receptor 2	Mus musculus	54-58
25510899-9	2015	Interestingly, pre-treatment of JAWSII cells with the TLR2-active lipid fraction significantly enhanced the uptake of the soluble beta-glucan, indicating the synergy between the TLR2 agonist component and the beta-glucan component.	beta-Glucans	130-141	toll-like receptor 2	Mus musculus	178-182
25510899-9	2015	Interestingly, pre-treatment of JAWSII cells with the TLR2-active lipid fraction significantly enhanced the uptake of the soluble beta-glucan, indicating the synergy between the TLR2 agonist component and the beta-glucan component.	beta-Glucans	209-220	toll-like receptor 2	Mus musculus	54-58
25510899-10	2015	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound beta-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.	beta-Glucans	115-126	TAO kinase 2	Mus musculus	48-51
25510899-10	2015	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound beta-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.	beta-Glucans	115-126	C-type lectin domain family 7, member a	Mus musculus	196-204
25510899-10	2015	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound beta-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.	beta-Glucans	115-126	toll-like receptor 2	Mus musculus	209-213
25461401-11	2015	CONCLUSIONS: beta-glucan of C. albicans induces a strong IL-1Ra response, which is independent of the beta-glucan receptors dectin-1 and CR3.	beta-Glucans	13-24	interleukin 1 receptor antagonist	Homo sapiens	57-63
25277753-3	2015	PP2 and PRT-060318 also inhibited beta-glucan-induced NET formation and reactive oxygen species (ROS) generation, suggesting that both responses are triggered by a Src/Syk-regulated signaling pathway.	beta-Glucans	34-45	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	0-3
25453580-2	2015	The role of the beta-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards beta-glucans is still unresolved.	beta-Glucans	119-131	C-type lectin domain containing 7A	Homo sapiens	38-46
25453580-3	2015	Dectin-1 is considered as the main beta-glucan receptor in mice, while recent studies in man show that CR3 is more important in beta-glucan-mediated responses.	beta-Glucans	35-46	C-type lectin domain family 7, member a	Mus musculus	0-8
25453580-7	2015	However, recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 are involved in the beta-glucan-mediated responses in pig macrophages.	beta-Glucans	24-36	C-type lectin domain containing 7A	Sus scrofa	73-81
25453580-7	2015	However, recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 are involved in the beta-glucan-mediated responses in pig macrophages.	beta-Glucans	24-35	C-type lectin domain containing 7A	Sus scrofa	73-81
25453580-8	2015	Moreover, CR3 signalling through focal adhesion kinase (FAK) was indispensable for beta-glucan-mediated ROS production and cytokine production in neutrophils and macrophages, while the Syk-dependent pathway was only partly involved in these responses.	beta-Glucans	83-94	protein tyrosine kinase 2	Homo sapiens	33-54
25453580-8	2015	Moreover, CR3 signalling through focal adhesion kinase (FAK) was indispensable for beta-glucan-mediated ROS production and cytokine production in neutrophils and macrophages, while the Syk-dependent pathway was only partly involved in these responses.	beta-Glucans	83-94	protein tyrosine kinase 2	Homo sapiens	56-59
25453580-10	2015	Nonetheless, FAK acts as a master switch that regulates beta-glucan-mediated responses in neutrophils as well as macrophages.	beta-Glucans	56-67	protein tyrosine kinase 2	Homo sapiens	13-16
25439872-1	2015	beta-Glucans from cereals are beta(1-3)(1-4)-mixed linkage linear homopolysaccharides of D-glucopyranosyl residues, recently recognised as functional components of foods with benefits in maintaining the health of the digestive tract not least through a prebiotic effect.	beta-Glucans	0-12	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	30-38
25277753-0	2015	Src family kinases and Syk are required for neutrophil extracellular trap formation in response to beta-glucan particles.	beta-Glucans	99-110	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
25277753-0	2015	Src family kinases and Syk are required for neutrophil extracellular trap formation in response to beta-glucan particles.	beta-Glucans	99-110	spleen associated tyrosine kinase	Homo sapiens	23-26
25277753-2	2015	beta-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively.	beta-Glucans	0-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	53-56
25277753-3	2015	PP2 and PRT-060318 also inhibited beta-glucan-induced NET formation and reactive oxygen species (ROS) generation, suggesting that both responses are triggered by a Src/Syk-regulated signaling pathway.	beta-Glucans	34-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	164-167
25277753-2	2015	beta-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively.	beta-Glucans	0-11	spleen associated tyrosine kinase	Homo sapiens	76-79
25277753-2	2015	beta-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively.	beta-Glucans	0-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-111
25277753-3	2015	PP2 and PRT-060318 also inhibited beta-glucan-induced NET formation and reactive oxygen species (ROS) generation, suggesting that both responses are triggered by a Src/Syk-regulated signaling pathway.	beta-Glucans	34-45	spleen associated tyrosine kinase	Homo sapiens	168-171
25277753-2	2015	beta-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively.	beta-Glucans	0-11	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	196-199
25277753-2	2015	beta-Glucan triggered a prolonged phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively.	beta-Glucans	0-11	spleen associated tyrosine kinase	Homo sapiens	213-216
25277753-7	2015	These findings were substantiated by the evidence that neutrophils from mice with the conditional deletion of Syk were defective in formation of NETs in response to beta-glucan.	beta-Glucans	165-176	spleen tyrosine kinase	Mus musculus	110-113
27118332-6	2015	We also show that oral administration of beta-glucan enhance intestinal and systemic immune response in dectin-1-dependent manner.	beta-Glucans	41-52	C-type lectin domain containing 7A	Homo sapiens	104-112
25620877-1	2015	The cellulose synthase-like gene HvCslF6, which is essential for (1,3;1,4)-beta-glucan biosynthesis in barley, collocates with quantitative trait loci (QTL) for grain (1,3;1,4)-beta-glucan concentration in several populations, including CDC Bold x TR251.	beta-Glucans	75-86	CslF6	Hordeum vulgare	33-40
25620877-1	2015	The cellulose synthase-like gene HvCslF6, which is essential for (1,3;1,4)-beta-glucan biosynthesis in barley, collocates with quantitative trait loci (QTL) for grain (1,3;1,4)-beta-glucan concentration in several populations, including CDC Bold x TR251.	beta-Glucans	177-188	CslF6	Hordeum vulgare	33-40
25620877-3	2015	Consistent with this, transient expression of full-length HvCslF6 cDNAs from CDC Bold and TR251 in Nicotianabenthamiana led to accumulation of similar amounts of (1,3;1,4)-beta-glucan accumulation.	beta-Glucans	172-183	CslF6	Hordeum vulgare	58-65
25620877-7	2015	While the results of this work indicate that naturally occurring quantitative differences in (1,3;1,4)-beta-glucan accumulation may be due to cis-regulated differences in HvCslF6 expression, these could not be attributed to any specific DNA sequence polymorphism.	beta-Glucans	103-114	CslF6	Hordeum vulgare	171-178
26084113-7	2015	RESULTS: Serum levels of CRP in the LPS group at 12 h were significantly higher than in the other groups, whereas serum IL-6 levels in the LPS and LPS + beta-glucan groups at 12 h were significantly decreased.	beta-Glucans	153-164	interleukin 6	Rattus norvegicus	120-124
26373179-4	2015	In TNF-alpha bioassay, the supernatant of macrophages stimulated with beta-Glucan had a significant cytotoxic effect on WEHI-164 cells (P = 0.023).	beta-Glucans	70-81	tumor necrosis factor	Mus musculus	3-12
25490199-0	2014	A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking beta-glucans.	beta-Glucans	127-139	C-type lectin domain family 7, member a	Mus musculus	74-82
25490199-7	2014	Our analysis of beta-glucans-masking components revealed that it is a chitin-like component, but not the mannose moiety on the sclerotic cells, that interferes with the binding of beta-glucans by human or murine Dectin-1.	beta-Glucans	16-28	C-type lectin domain family 7, member a	Mus musculus	212-220
25490199-7	2014	Our analysis of beta-glucans-masking components revealed that it is a chitin-like component, but not the mannose moiety on the sclerotic cells, that interferes with the binding of beta-glucans by human or murine Dectin-1.	beta-Glucans	180-192	C-type lectin domain family 7, member a	Mus musculus	212-220
25239812-3	2014	In the present study, we have demonstrated that beta-glucan up-regulates Dectin1 and LPS up-regulates TLR4 directly, as confirmed by generation of siDectin1 and siTLR4 in rat MECs.	beta-Glucans	48-59	C-type lectin domain containing 7A	Rattus norvegicus	73-80
25474109-5	2014	We report that in addition to its known ability to directly prime T cells toward the Th17 lineage, IL-1 by promoting the transcriptional cofactor inhibitor of kappaB-zeta (IkappaB-zeta) also programs beta-glucan-exposed DCs to express cell adhesion and migration mediators, antimicrobial molecules, and Th17-polarizing factors.	beta-Glucans	200-211	NFKB inhibitor zeta	Homo sapiens	172-184
25474109-7	2014	Thus, our results identify IL-1 and IFN-gamma as regulators of DC programming by beta-glucan.	beta-Glucans	81-92	interferon gamma	Homo sapiens	36-45
25239812-3	2014	In the present study, we have demonstrated that beta-glucan up-regulates Dectin1 and LPS up-regulates TLR4 directly, as confirmed by generation of siDectin1 and siTLR4 in rat MECs.	beta-Glucans	48-59	toll-like receptor 4	Rattus norvegicus	102-106
25239812-4	2014	Then our results have described that either beta-glucan or LPS can activate RelB and/or p65 in rat MECs.	beta-Glucans	44-55	RELB proto-oncogene, NF-kB subunit	Rattus norvegicus	76-80
25239812-4	2014	Then our results have described that either beta-glucan or LPS can activate RelB and/or p65 in rat MECs.	beta-Glucans	44-55	synaptotagmin 1	Rattus norvegicus	88-91
25239812-5	2014	Furthermore, the association of p65 and RelB has been analyzed that collaboration of beta-glucan and LPS promotes p65/RelB heterodimers, producing inflammatory responses in rat MECs.	beta-Glucans	85-96	synaptotagmin 1	Rattus norvegicus	32-35
25239812-5	2014	Furthermore, the association of p65 and RelB has been analyzed that collaboration of beta-glucan and LPS promotes p65/RelB heterodimers, producing inflammatory responses in rat MECs.	beta-Glucans	85-96	RELB proto-oncogene, NF-kB subunit	Rattus norvegicus	40-44
25239812-5	2014	Furthermore, the association of p65 and RelB has been analyzed that collaboration of beta-glucan and LPS promotes p65/RelB heterodimers, producing inflammatory responses in rat MECs.	beta-Glucans	85-96	synaptotagmin 1	Rattus norvegicus	114-117
25239812-5	2014	Furthermore, the association of p65 and RelB has been analyzed that collaboration of beta-glucan and LPS promotes p65/RelB heterodimers, producing inflammatory responses in rat MECs.	beta-Glucans	85-96	RELB proto-oncogene, NF-kB subunit	Rattus norvegicus	118-122
25239812-6	2014	In conclusion, summary of our present results suggests that beta-glucan can be considered as a potential immuno-modulator, which s with TLR4 via NF-kappaB subunits to initiate and regulate the innate immunity in rat MECs.	beta-Glucans	60-71	toll-like receptor 4	Rattus norvegicus	136-140
25246527-1	2014	Dectin-1 recognizes beta-glucan and plays important roles for the antifungal immunity through the activation of spleen tyrosine kinase (Syk) in dendritic cells or macrophages.	beta-Glucans	20-31	C-type lectin domain containing 7A	Rattus norvegicus	0-8
25251945-0	2014	Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk.	beta-Glucans	45-57	C-type lectin domain containing 7A	Homo sapiens	62-70
25251945-0	2014	Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk.	beta-Glucans	45-57	spleen associated tyrosine kinase	Homo sapiens	75-78
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	beta-Glucans	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	beta-Glucans	4-15	C-C motif chemokine ligand 2	Homo sapiens	75-79
25251945-9	2014	beta-glucans and Candida albicans induced Syk phosphorylation, and Syk inhibition significantly decreased beta-glucan-induced chemokine secretion from IECs.	beta-Glucans	0-12	spleen associated tyrosine kinase	Homo sapiens	42-45
25251945-9	2014	beta-glucans and Candida albicans induced Syk phosphorylation, and Syk inhibition significantly decreased beta-glucan-induced chemokine secretion from IECs.	beta-Glucans	0-11	spleen associated tyrosine kinase	Homo sapiens	42-45
25251945-10	2014	Thus, IECs may respond to beta-glucans by the secretion of pro-inflammatory chemokines in a Dectin-1- and Syk-dependent pathway, via receptors and a signaling pathway described to date only for myeloid cells.	beta-Glucans	26-38	C-type lectin domain containing 7A	Homo sapiens	92-100
25251945-10	2014	Thus, IECs may respond to beta-glucans by the secretion of pro-inflammatory chemokines in a Dectin-1- and Syk-dependent pathway, via receptors and a signaling pathway described to date only for myeloid cells.	beta-Glucans	26-38	spleen associated tyrosine kinase	Homo sapiens	106-109
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	beta-Glucans	17-29	interleukin 6	Homo sapiens	112-116
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	beta-Glucans	17-29	interleukin 23 subunit alpha	Homo sapiens	118-123
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	beta-Glucans	17-29	interleukin 10	Homo sapiens	125-130
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	beta-Glucans	17-29	tumor necrosis factor	Homo sapiens	136-163
24748716-6	2014	The lys5 mutation conditioned low grain weight and starch content, but exceptionally high beta-glucan contents.	beta-Glucans	90-101	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	4-8
24982422-0	2014	The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by beta-glucans.	beta-Glucans	146-158	interleukin 23 subunit alpha	Homo sapiens	119-124
24821724-2	2014	Dectin 1, a lectin receptor for beta-glucan, is found predominantly on cells of the myeloid lineage.	beta-Glucans	32-43	C-type lectin domain family 7, member a	Mus musculus	0-8
24732035-2	2014	This complex can be used as a Dectin-1 targeting delivery for therapeutic oligonucleotides (ODN), where Dectin-1 is a membrane receptor of immunocyte cell that can recognize beta-glucans.	beta-Glucans	174-186	C-type lectin domain family 7, member a	Mus musculus	30-38
24732035-2	2014	This complex can be used as a Dectin-1 targeting delivery for therapeutic oligonucleotides (ODN), where Dectin-1 is a membrane receptor of immunocyte cell that can recognize beta-glucans.	beta-Glucans	174-186	C-type lectin domain family 7, member a	Mus musculus	104-112
24721111-2	2014	Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs).	beta-Glucans	49-60	C-type lectin domain containing 7A	Homo sapiens	128-136
24604295-0	2014	beta-glucan reduces exercise-induced stress through downregulation of c-Fos and c-Jun expression in the brains of exhausted rats.	beta-Glucans	0-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-75
24604295-4	2014	In the present study, the effects of beta-glucan on the expression of the oncogenes c-Fos and c-Jun in the hypothalamus, dentate gyrus and dorsal raphe in rats following exhaustive treadmill running were investigated.	beta-Glucans	37-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
24604295-10	2014	Administration of beta-glucan resulted in an increase in the time to exhaustion and the suppression of the exercise-induced increment in c-Fos and c-Jun expression.	beta-Glucans	18-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	137-142
24604295-11	2014	In conclusion, beta-glucan may exert an alleviating effect on exercise-induced stress through the suppression of c-Fos and c-Jun expression in the brains of exhausted rats.	beta-Glucans	15-26	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	113-118
24669944-0	2014	Textural and Rheological Properties of Oat Beta-Glucan Gels with Varying Molecular Weight Composition.	beta-Glucans	43-54	ornithine aminotransferase	Homo sapiens	39-42
24293021-9	2014	Insights into the interaction of the short beta(1-3)-glucans with Dectin-1 CTLD provide a basis to understand the molecular mechanisms of beta-glucan recognition and cellular activation by Dectin-1.	beta-Glucans	138-149	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	43-51
24293021-9	2014	Insights into the interaction of the short beta(1-3)-glucans with Dectin-1 CTLD provide a basis to understand the molecular mechanisms of beta-glucan recognition and cellular activation by Dectin-1.	beta-Glucans	138-149	C-type lectin domain containing 7A	Homo sapiens	66-74
24293021-9	2014	Insights into the interaction of the short beta(1-3)-glucans with Dectin-1 CTLD provide a basis to understand the molecular mechanisms of beta-glucan recognition and cellular activation by Dectin-1.	beta-Glucans	138-149	C-type lectin domain containing 7A	Homo sapiens	189-197
25143443-0	2014	Fungal beta-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response.	beta-Glucans	7-18	C-type lectin domain family 7, member a	Mus musculus	22-30
25143443-2	2014	Immune cells recognize these beta-glucans through a cell surface pathogen recognition receptor called Dectin-1.	beta-Glucans	29-41	C-type lectin domain family 7, member a	Mus musculus	102-110
25143443-6	2014	Treatment of prediabetic NOD mice with low-dose beta-glucan resulted in a profound delay in hyperglycemia, and this protection was associated with increase in the frequencies of Foxp3(+), LAP(+), and GARP(+) T cells.	beta-Glucans	48-59	forkhead box P3	Mus musculus	178-183
25143443-6	2014	Treatment of prediabetic NOD mice with low-dose beta-glucan resulted in a profound delay in hyperglycemia, and this protection was associated with increase in the frequencies of Foxp3(+), LAP(+), and GARP(+) T cells.	beta-Glucans	48-59	eye lens aplasia	Mus musculus	188-191
25143443-6	2014	Treatment of prediabetic NOD mice with low-dose beta-glucan resulted in a profound delay in hyperglycemia, and this protection was associated with increase in the frequencies of Foxp3(+), LAP(+), and GARP(+) T cells.	beta-Glucans	48-59	CD109 antigen	Mus musculus	200-204
25143443-7	2014	Upon Ag presentation, beta-glucan-exposed dendritic cells induced a significant increase in Foxp3(+) and LAP(+) T cells in in vitro cultures.	beta-Glucans	22-33	forkhead box P3	Mus musculus	92-97
25143443-7	2014	Upon Ag presentation, beta-glucan-exposed dendritic cells induced a significant increase in Foxp3(+) and LAP(+) T cells in in vitro cultures.	beta-Glucans	22-33	eye lens aplasia	Mus musculus	105-108
24808366-1	2014	Dectin-1 is a membrane-bound pattern recognition receptor for beta-glucans, which are the main constituents of fungal cell walls.	beta-Glucans	62-74	C-type lectin domain containing 7A	Homo sapiens	0-8
24808366-2	2014	Detection of beta-glucans by dectin-1 triggers an effective innate immune response.	beta-Glucans	13-25	C-type lectin domain containing 7A	Homo sapiens	29-37
24860587-3	2014	Besides HvCslF6, amo1 and AGPL2, sex6, and waxy were identified among the major genes responsible for beta-glucan, amylose and amylopectin content, respectively.	beta-Glucans	102-113	CslF6	Hordeum vulgare	8-15
24795361-2	2014	Here, we show that intratumoral delivery of the beta-glucan curdlan, a ligand of dectin-1, blocks the generation of iTh2 cells and prevents breast cancer progression in vivo.	beta-Glucans	48-59	C-type lectin domain family 7, member a	Mus musculus	81-89
25229859-2	2014	Recombinant dectin-1 specifically bound to some beta-glucans, and the neck domain and N-linked oligosaccharide chains of human dectin-1 did not affect the ligand binding activity and specificity of the receptor.	beta-Glucans	48-60	C-type lectin domain containing 7A	Homo sapiens	12-20
25081694-0	2014	Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.	beta-Glucans	10-21	interleukin 4	Homo sapiens	69-73
25081694-9	2014	At the end of the study, the change in the serum level of IL-4 in the beta glucan group in comparison with the placebo group was statistically significant (p=0.001).	beta-Glucans	70-81	interleukin 4	Homo sapiens	58-62
24118943-3	2014	Previously, we found that in S. cerevisiae the deletion of MCD4 gene causes exposure of beta-glucans on the cell surface and that the mcd4 deletion mutant strongly enhances immunity in vitro and in vivo.	beta-Glucans	88-100	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	59-63
24418375-0	2014	beta-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway.	beta-Glucans	0-11	GLI family zinc finger 2	Homo sapiens	70-75
24418375-0	2014	beta-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway.	beta-Glucans	0-11	mitogen-activated protein kinase 1	Homo sapiens	90-93
24418375-0	2014	beta-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway.	beta-Glucans	0-11	mitogen-activated protein kinase 3	Homo sapiens	94-98
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	CD86 molecule	Homo sapiens	23-27
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	CD80 molecule	Homo sapiens	32-36
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	interleukin 2	Homo sapiens	115-119
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	tumor necrosis factor	Homo sapiens	134-143
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	interferon gamma	Homo sapiens	148-157
24418375-5	2014	However, beta-glucan inhibited p38 MAPK activation.	beta-Glucans	9-20	mitogen-activated protein kinase 1	Homo sapiens	31-34
24418375-5	2014	However, beta-glucan inhibited p38 MAPK activation.	beta-Glucans	9-20	mitogen-activated protein kinase 3	Homo sapiens	35-39
24418375-6	2014	In experiments with monocytes derived from healthy donors, beta-glucan inhibited IL-8, IL-12 and TNF-alpha production.	beta-Glucans	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
24418375-6	2014	In experiments with monocytes derived from healthy donors, beta-glucan inhibited IL-8, IL-12 and TNF-alpha production.	beta-Glucans	59-70	tumor necrosis factor	Homo sapiens	97-106
24418375-8	2014	CONCLUSIONS: beta-glucan inhibited oxLDL-induced pro-inflammatory effects in macrophages via regulation of p38 MAPK phosphorylation.	beta-Glucans	13-24	mitogen-activated protein kinase 1	Homo sapiens	107-110
24418375-8	2014	CONCLUSIONS: beta-glucan inhibited oxLDL-induced pro-inflammatory effects in macrophages via regulation of p38 MAPK phosphorylation.	beta-Glucans	13-24	mitogen-activated protein kinase 3	Homo sapiens	111-115
23768398-7	2013	In the present study, we hypothesise the mechanism of the inhibition of beta-glucan degradation by superoxide dismutase.	beta-Glucans	72-83	superoxide dismutase 1	Homo sapiens	99-119
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	beta-Glucans	109-120	catalase	Homo sapiens	16-24
24723960-2	2014	Using ovalbumin (OVA) as a hypersensitivity inducer, we evaluated the ability of mushroom beta-glucan (MBG) in modulating Th1/Th2 cell responses in B6 mice.	beta-Glucans	90-101	negative elongation factor complex member C/D, Th1l	Mus musculus	122-125
25180094-3	2014	The aim of the study was to further investigate the serum levels of IL-10 in patients with sarcoidosis and relate them to fungal exposure in terms of the amount of fungi in the air of their homes and beta-glucan in bronchoalveolar lavage (BAL) fluid.	beta-Glucans	200-211	interleukin 10	Homo sapiens	68-73
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	beta-Glucans	109-120	superoxide dismutase 1	Homo sapiens	29-49
23851679-6	2013	Dietary supplementation of oat beta-glucan prevented most of the LPS-induced metabolic disorders, and improved hepatic steatosis and inflammation, although a dose-dependent effect was not observed.	beta-Glucans	31-42	toll-like receptor 4	Mus musculus	65-68
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	beta-Glucans	109-120	superoxide dismutase 1	Homo sapiens	51-54
23916470-5	2013	We demonstrate that intracellular galectin-3 negatively regulates Th17 polarization in response to the dectin-1 agonist curdlan (a beta-glucan present on the cell wall of fungal species) and lipopolysaccharide, agents that prime DCs for Th17 differentiation.	beta-Glucans	131-142	lectin, galactose binding, soluble 3	Mus musculus	34-44
23916470-5	2013	We demonstrate that intracellular galectin-3 negatively regulates Th17 polarization in response to the dectin-1 agonist curdlan (a beta-glucan present on the cell wall of fungal species) and lipopolysaccharide, agents that prime DCs for Th17 differentiation.	beta-Glucans	131-142	C-type lectin domain family 7, member a	Mus musculus	103-111
23831551-2	2013	In mammals, myeloid cells express several receptors capable of recognizing beta-glucans, with the C-type lectin receptor dectin-1 in conjunction with Toll-like receptor 2 (TLR2), considered key receptors for recognition of beta-glucan.	beta-Glucans	75-87	toll like receptor 2	Homo sapiens	172-176
23831551-2	2013	In mammals, myeloid cells express several receptors capable of recognizing beta-glucans, with the C-type lectin receptor dectin-1 in conjunction with Toll-like receptor 2 (TLR2), considered key receptors for recognition of beta-glucan.	beta-Glucans	75-86	toll like receptor 2	Homo sapiens	172-176
24198746-8	2013	Taken together, these results suggest that, during fungal infection, beta-glucan-stimulated Dectin-1 may cooperate with TLR4 to specifically enhance IgG1 production by mouse B cells.	beta-Glucans	69-80	C-type lectin domain family 7, member a	Mus musculus	92-100
24198746-8	2013	Taken together, these results suggest that, during fungal infection, beta-glucan-stimulated Dectin-1 may cooperate with TLR4 to specifically enhance IgG1 production by mouse B cells.	beta-Glucans	69-80	toll-like receptor 4	Mus musculus	120-124
24198746-8	2013	Taken together, these results suggest that, during fungal infection, beta-glucan-stimulated Dectin-1 may cooperate with TLR4 to specifically enhance IgG1 production by mouse B cells.	beta-Glucans	69-80	LOC105243590	Mus musculus	149-153
23851679-7	2013	In conclusion, oat beta-glucan could inhibit LPS-induced NASH in mice.	beta-Glucans	19-30	toll-like receptor 4	Mus musculus	45-48
23424205-0	2013	Effects of beta-glucan extracted from Agaricus blazei on the expression of ERCC5, CASP9, and CYP1A1 genes and metabolic profile in HepG2 cells.	beta-Glucans	11-22	ERCC excision repair 5, endonuclease	Homo sapiens	75-80
23749474-2	2013	Fungal beta-glucan recognition by the receptor Dectin-1 triggers inflammatory immune responses in macrophages and dendritic cells that are appropriate for defense against fungal pathogens.	beta-Glucans	7-18	C-type lectin domain containing 7A	Homo sapiens	47-55
23749474-4	2013	Studies documenting LC3"s recruitment to phagosomes containing beta-glucan and other nonsugar particles suggest that LC3 plays a role in regulating phagocytosis and its related immunological responses.	beta-Glucans	63-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	20-23
23749474-4	2013	Studies documenting LC3"s recruitment to phagosomes containing beta-glucan and other nonsugar particles suggest that LC3 plays a role in regulating phagocytosis and its related immunological responses.	beta-Glucans	63-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	117-120
23787127-6	2013	TLR2 expression seemed to affect the Dectin-1-dependent production of CXCL8 to beta-glucan containing zymosan as well as Listeria monocytogenes.	beta-Glucans	79-90	toll like receptor 2	Homo sapiens	0-4
23787127-6	2013	TLR2 expression seemed to affect the Dectin-1-dependent production of CXCL8 to beta-glucan containing zymosan as well as Listeria monocytogenes.	beta-Glucans	79-90	C-type lectin domain containing 7A	Homo sapiens	37-45
23786444-5	2013	The culture supernatant of Aureobasidium pullulans (A. pullulans, which contains predominantly soluble beta-glucan), which binds to cell membrane-localized TLR, and to C-type lectin receptor Dectin-1, was treated together with R-848 to THP-1 macrophages.	beta-Glucans	103-114	GLI family zinc finger 2	Homo sapiens	236-241
23424205-8	2013	However, the CYP1A1 gene expression was also induced by HepG2 cells exposed to B[a]P only or in association with beta-glucan, showing its effective protector against damage caused by B[a]P, while HepG2 cells exposed to only beta-glucan did not show CYP1A1 modulation.	beta-Glucans	113-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	249-255
23424205-8	2013	However, the CYP1A1 gene expression was also induced by HepG2 cells exposed to B[a]P only or in association with beta-glucan, showing its effective protector against damage caused by B[a]P, while HepG2 cells exposed to only beta-glucan did not show CYP1A1 modulation.	beta-Glucans	224-235	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
23424205-0	2013	Effects of beta-glucan extracted from Agaricus blazei on the expression of ERCC5, CASP9, and CYP1A1 genes and metabolic profile in HepG2 cells.	beta-Glucans	11-22	caspase 9	Homo sapiens	82-87
23424205-0	2013	Effects of beta-glucan extracted from Agaricus blazei on the expression of ERCC5, CASP9, and CYP1A1 genes and metabolic profile in HepG2 cells.	beta-Glucans	11-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
23424205-4	2013	The objective of the present study was to verify the protective effect of beta-glucan on the expression of the genes ERCC5 (involved in excision repair of DNA damage), CASP9 (involved in apoptosis), and CYP1A1 (involved in the metabolism of xenobiotics) using real-time polymerase chain reaction and perform metabolic profile measurements on the HepG2 cells.	beta-Glucans	74-85	ERCC excision repair 5, endonuclease	Homo sapiens	117-122
23424205-4	2013	The objective of the present study was to verify the protective effect of beta-glucan on the expression of the genes ERCC5 (involved in excision repair of DNA damage), CASP9 (involved in apoptosis), and CYP1A1 (involved in the metabolism of xenobiotics) using real-time polymerase chain reaction and perform metabolic profile measurements on the HepG2 cells.	beta-Glucans	74-85	caspase 9	Homo sapiens	168-173
23424205-4	2013	The objective of the present study was to verify the protective effect of beta-glucan on the expression of the genes ERCC5 (involved in excision repair of DNA damage), CASP9 (involved in apoptosis), and CYP1A1 (involved in the metabolism of xenobiotics) using real-time polymerase chain reaction and perform metabolic profile measurements on the HepG2 cells.	beta-Glucans	74-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	203-209
23424205-6	2013	The results demonstrated that 50 microg/mL beta-glucan significantly repressed the expression of the ERCC5 gene when compared with the untreated control cells in these conditions.	beta-Glucans	43-54	ERCC excision repair 5, endonuclease	Homo sapiens	101-106
23424205-8	2013	However, the CYP1A1 gene expression was also induced by HepG2 cells exposed to B[a]P only or in association with beta-glucan, showing its effective protector against damage caused by B[a]P, while HepG2 cells exposed to only beta-glucan did not show CYP1A1 modulation.	beta-Glucans	113-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
23424024-4	2013	Treatment of orally administered yeast-derived particulate beta-glucan drastically downregulated MDSCs but increased the infiltrated DCs and macrophages in tumor-bearing mice, thus eliciting CTL and Th1 responses, inhibiting the suppressive activity of regulatory T cells, thereby leading to the delayed tumor progression.	beta-Glucans	59-70	negative elongation factor complex member C/D, Th1l	Mus musculus	199-202
23518266-2	2013	Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands.	beta-Glucans	38-49	C-type lectin domain family 7, member a	Mus musculus	59-67
23518266-3	2013	In the first model, we explored the role of Dectin-1 in the ability of soluble purified beta-glucans to mediate protection against systemic Staphylococcus aureus infection in mice.	beta-Glucans	88-100	C-type lectin domain family 7, member a	Mus musculus	44-52
23514738-4	2013	A macrophage cell line expressing Dectin-1 was employed to show binding and activation of Dectin-1 signal transduction pathway by the beta-glucan-containing vaccine.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	34-42
23637950-1	2013	BACKGROUND: beta-glucans are fungal cell wall components that bind to the C-type lectin-like receptor dectin-1.	beta-Glucans	12-24	C-type lectin domain containing 7A	Homo sapiens	102-110
23637950-3	2013	The purpose of this study has been addressing the response of human macrophages to beta-glucans under different conditions mimicking the composition of the inflammatory milieu in view of the wide plasticity and large range of phenotypical changes showed by these cells, and the relevant role of dectin-1 in several pathophysiological conditions.	beta-Glucans	83-95	C-type lectin domain containing 7A	Homo sapiens	295-303
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	tumor necrosis factor	Homo sapiens	109-117
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	interleukin 1 beta	Homo sapiens	122-130
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	interleukin 6	Homo sapiens	153-157
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	interleukin 23 subunit alpha	Homo sapiens	162-167
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	196-212
23544515-5	2013	The beta-glucans were incubated with THP-1 derived macrophages, for 3 h and 6 h to evaluate their effects on the expression of pro-inflammatory genes.	beta-Glucans	4-16	GLI family zinc finger 2	Homo sapiens	37-42
23514738-4	2013	A macrophage cell line expressing Dectin-1 was employed to show binding and activation of Dectin-1 signal transduction pathway by the beta-glucan-containing vaccine.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	90-98
23187951-6	2013	The present study indicates that 8 weeks daily intake of 3 g of beta-glucans significantly reduces total cholesterol, LDL, ApoA1 and ApoB in MG patients.	beta-Glucans	64-76	apolipoprotein A1	Homo sapiens	123-128
23187951-6	2013	The present study indicates that 8 weeks daily intake of 3 g of beta-glucans significantly reduces total cholesterol, LDL, ApoA1 and ApoB in MG patients.	beta-Glucans	64-76	apolipoprotein B	Homo sapiens	133-137
22878139-0	2012	Agaricus brasiliensis-derived beta-glucans exert immunoenhancing effects via a dectin-1-dependent pathway.	beta-Glucans	30-42	C-type lectin domain family 7, member a	Mus musculus	79-87
23261364-2	2013	The beta-glucan binding of dectin-1 can induce its own intracellular signaling and can mediate a variety of cellular responses.	beta-Glucans	4-15	C-type lectin domain containing 7A	Rattus norvegicus	27-35
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	C-type lectin domain containing 7A	Rattus norvegicus	73-80
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	spleen associated tyrosine kinase	Rattus norvegicus	81-84
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	toll-like receptor 4	Rattus norvegicus	116-120
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	122-127
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	tumor necrosis factor	Rattus norvegicus	157-166
23261364-8	2013	Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion.	beta-Glucans	43-54	interleukin 1 beta	Rattus norvegicus	171-179
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	33-44	C-type lectin domain containing 7A	Rattus norvegicus	59-66
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	33-44	spleen associated tyrosine kinase	Rattus norvegicus	67-70
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	33-44	toll-like receptor 4	Rattus norvegicus	99-103
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	33-44	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	104-109
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	250-261	C-type lectin domain containing 7A	Rattus norvegicus	59-66
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	250-261	spleen associated tyrosine kinase	Rattus norvegicus	67-70
23261364-12	2013	These findings demonstrated that beta-glucan activation of Dectin1/Syk attenuated LPS induction of TLR4/MyD88/NF-kappaB and inhibited the LPS-induced inflammation factors in mammary epithelial cells, thereby providing a possibly protective effect of beta-glucan in the prevention of LPS-induced dysfunction in mammary epithelial cells.	beta-Glucans	250-261	toll-like receptor 4	Rattus norvegicus	99-103
22847544-6	2012	The level of beta-glucan induced interferon (IFN)-gamma in her blood cells was significantly low.	beta-Glucans	13-24	interferon gamma	Homo sapiens	33-55
23036747-5	2013	RESULTS: HDM-derived beta-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than beta-glucans/TLR2, was critical to HDM-induced AA.	beta-Glucans	21-33	toll-like receptor 2	Mus musculus	167-187
23036747-5	2013	RESULTS: HDM-derived beta-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than beta-glucans/TLR2, was critical to HDM-induced AA.	beta-Glucans	21-33	toll-like receptor 2	Mus musculus	189-193
23036747-5	2013	RESULTS: HDM-derived beta-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than beta-glucans/TLR2, was critical to HDM-induced AA.	beta-Glucans	21-33	toll-like receptor 4	Mus musculus	207-211
23036747-5	2013	RESULTS: HDM-derived beta-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than beta-glucans/TLR2, was critical to HDM-induced AA.	beta-Glucans	21-33	toll-like receptor 4	Mus musculus	230-234
23036747-5	2013	RESULTS: HDM-derived beta-glucans, rather than LPS, were proven to be essential to activating innate immunity in the nasal mucosa and triggering AR, which depended on Toll-like receptor 2 (TLR2), but not on TLR4; however, the LPS/TLR4 signaling axis, rather than beta-glucans/TLR2, was critical to HDM-induced AA.	beta-Glucans	21-33	toll-like receptor 2	Mus musculus	276-280
23036747-6	2013	These differences were attributed to the specific role of beta-glucans and LPS in inducing the surface expression of TLR2 and TLR4 and their translocation to lipid rafts in nasal and bronchial epithelial cells, respectively.	beta-Glucans	58-70	toll-like receptor 2	Mus musculus	117-121
23036747-6	2013	These differences were attributed to the specific role of beta-glucans and LPS in inducing the surface expression of TLR2 and TLR4 and their translocation to lipid rafts in nasal and bronchial epithelial cells, respectively.	beta-Glucans	58-70	toll-like receptor 4	Mus musculus	126-130
23036747-7	2013	We also showed that dual oxidase 2-generated reactive oxygen species mediate both beta-glucan-induced TLR2 activation and LPS-induced TLR4 activation.	beta-Glucans	82-93	dual oxidase 2	Mus musculus	20-34
23036747-7	2013	We also showed that dual oxidase 2-generated reactive oxygen species mediate both beta-glucan-induced TLR2 activation and LPS-induced TLR4 activation.	beta-Glucans	82-93	toll-like receptor 2	Mus musculus	102-106
23218290-9	2013	Remarkably, the beta-glucan induced a 16.9% increase in activated CD19+ B lymphocytes compared with the control sample.	beta-Glucans	16-27	CD19 antigen	Mus musculus	66-70
22902620-2	2012	Dectin-1 binds to beta-glucans in fungal cell walls and triggers phagocytosis, production of reactive oxygen by the NADPH oxidase, and inflammatory cytokine production which all contribute to host immune responses against fungi.	beta-Glucans	18-30	C-type lectin domain containing 7A	Homo sapiens	0-8
22750202-3	2012	However, the effects of beta-glucans on LPS-induced inflammatory responses are poorly understood.	beta-Glucans	24-36	toll-like receptor 4	Mus musculus	40-43
22744837-0	2012	Structure of a beta-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-kappaB signaling.	beta-Glucans	15-26	C-type lectin domain family 7, member a	Mus musculus	88-96
21725986-2	2012	The aim of the present study was to evaluate the potential protective effects of a novel soluble beta-glucan salecan on acute liver injury induced by CCl4 in mice and to further explore the underlying mechanisms.	beta-Glucans	97-108	chemokine (C-C motif) ligand 4	Mus musculus	150-154
22962686-0	2012	Dectin-1 and IL-17A suppress murine asthma induced by Aspergillus versicolor but not Cladosporium cladosporioides due to differences in beta-glucan surface exposure.	beta-Glucans	136-147	C-type lectin domain family 7, member a	Mus musculus	0-8
22962686-0	2012	Dectin-1 and IL-17A suppress murine asthma induced by Aspergillus versicolor but not Cladosporium cladosporioides due to differences in beta-glucan surface exposure.	beta-Glucans	136-147	interleukin 17A	Mus musculus	13-19
22237725-9	2012	beta-glucan treatment also slightly enhanced the activity of CAT and prevented the depletion of GSH-Px activity caused by EMR, but not statistically significantly.	beta-Glucans	0-11	catalase	Rattus norvegicus	61-64
24009832-0	2012	Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.	beta-Glucans	27-38	C-type lectin domain containing 7A	Homo sapiens	68-76
24009832-3	2012	beta-Glucans are glucose polymers of a linear beta(1,3)-glucan backbone with beta(1,6)-linked side chains.	beta-Glucans	0-12	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	46-54
24009832-3	2012	beta-Glucans are glucose polymers of a linear beta(1,3)-glucan backbone with beta(1,6)-linked side chains.	beta-Glucans	0-12	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-85
24009832-7	2012	Dectin-1 receptor systems have been incorporated as the PRRs of beta-glucans in the innate immune cells of higher animal systems, which function on the front line against fungal infection, and have been exploited in cancer treatments to enhance systemic immune function.	beta-Glucans	64-76	C-type lectin domain containing 7A	Homo sapiens	0-8
24009832-8	2012	Dectin-1 on macrophages and DCs performs dual functions: internalization of beta-glucan-containing particles and transmittance of its signals into the nucleus.	beta-Glucans	76-87	C-type lectin domain containing 7A	Homo sapiens	0-8
24009832-9	2012	This review will depict in detail how the physicochemical nature of beta-glucan contributes to its immunostimulating effect in hosts and the potential uses of beta-glucan by elucidating the dectin-1 signal transduction pathway.	beta-Glucans	68-79	C-type lectin domain containing 7A	Homo sapiens	190-198
22744837-0	2012	Structure of a beta-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-kappaB signaling.	beta-Glucans	15-26	spleen tyrosine kinase	Mus musculus	97-100
22744837-0	2012	Structure of a beta-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-kappaB signaling.	beta-Glucans	15-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
22817337-7	2012	In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection.	beta-Glucans	19-30	interleukin 1 beta	Homo sapiens	100-108
22393029-9	2012	The beta-glucans content of the diet altered blood concentrations of erythrocytes and leukocytes, CD4, CD45RA, and CD8 blood cells (P &lt; 0.05).	beta-Glucans	4-16	CD4 molecule	Sus scrofa	98-101
22343219-0	2012	Glycosphingolipids mediate pneumocystis cell wall beta-glucan activation of the IL-23/IL-17 axis in human dendritic cells.	beta-Glucans	50-61	interleukin 23 subunit alpha	Homo sapiens	80-85
22817337-7	2012	In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection.	beta-Glucans	19-30	interleukin 6	Homo sapiens	110-114
22817337-7	2012	In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection.	beta-Glucans	19-30	tumor necrosis factor	Homo sapiens	120-129
22624959-4	2012	In this review, we will describe and compare the molecular mechanisms that regulate phagocytosis triggered by Fcgamma receptors, which mediate the uptake of immunoglobulin G-opsonized targets, and Dectin-1, which is responsible for internalization of fungi with exposed cell wall beta-glucan.	beta-Glucans	280-291	C-type lectin domain containing 7A	Homo sapiens	197-205
22343219-0	2012	Glycosphingolipids mediate pneumocystis cell wall beta-glucan activation of the IL-23/IL-17 axis in human dendritic cells.	beta-Glucans	50-61	interleukin 17A	Homo sapiens	86-91
22343219-3	2012	In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6.	beta-Glucans	55-66	interleukin 23 subunit alpha	Homo sapiens	150-155
22343219-3	2012	In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6.	beta-Glucans	55-66	interleukin 6	Homo sapiens	160-164
22343219-8	2012	These data strongly support the idea that the beta-glucan surface components of Pneumocystis drive the activation of the IL-23/IL-17 axis during this infection, through a glycosphingolipid-initiated mechanism.	beta-Glucans	46-57	interleukin 23 subunit alpha	Homo sapiens	121-126
22343219-8	2012	These data strongly support the idea that the beta-glucan surface components of Pneumocystis drive the activation of the IL-23/IL-17 axis during this infection, through a glycosphingolipid-initiated mechanism.	beta-Glucans	46-57	interleukin 17A	Homo sapiens	127-132
22503982-0	2012	Discharge of solubilized and Dectin-1-reactive beta-glucan from macrophage cells phagocytizing insoluble beta-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.	beta-Glucans	47-58	C-type lectin domain family 7, member a	Mus musculus	29-37
22649195-0	2012	Relative contributions of dectin-1 and complement to immune responses to particulate beta-glucans.	beta-Glucans	85-97	C-type lectin domain family 7, member a	Mus musculus	26-34
22489616-8	2012	The most evident effects of beta-glucan were the overexpression of the genes TNFalpha, MPO, TRF, and LYZ.	beta-Glucans	28-39	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	77-85
22489616-8	2012	The most evident effects of beta-glucan were the overexpression of the genes TNFalpha, MPO, TRF, and LYZ.	beta-Glucans	28-39	myeloid-specific peroxidase	Danio rerio	87-90
22489616-8	2012	The most evident effects of beta-glucan were the overexpression of the genes TNFalpha, MPO, TRF, and LYZ.	beta-Glucans	28-39	TBP-like 1	Danio rerio	92-95
22489616-8	2012	The most evident effects of beta-glucan were the overexpression of the genes TNFalpha, MPO, TRF, and LYZ.	beta-Glucans	28-39	lysozyme	Danio rerio	101-104
22951656-15	2012	There was no difference in IL-12 levels between the groups, while there was a certain decrease in TNF-alpha level in beta-glucan, spiramycin, BG-S group in comparison to the control group.	beta-Glucans	117-128	tumor necrosis factor	Mus musculus	98-107
22620860-4	2012	Oat slurries treated with lichenase or lichenase combined with alpha-amylase and/or proteinase reduced the molecular weight of beta-glucan.	beta-Glucans	127-138	endogenous retrovirus group K member 10	Homo sapiens	84-94
22620860-7	2012	Heated oat slurries treated with lichenase or lichenase combined with alpha-amylase and/or proteinase bound the least amount of bile acid, indicating the contribution of beta-glucan to binding.	beta-Glucans	170-181	endogenous retrovirus group K member 10	Homo sapiens	91-101
22503982-0	2012	Discharge of solubilized and Dectin-1-reactive beta-glucan from macrophage cells phagocytizing insoluble beta-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.	beta-Glucans	105-116	C-type lectin domain family 7, member a	Mus musculus	29-37
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	46-57	C-type lectin domain family 7, member a	Mus musculus	34-42
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	46-57	C-type lectin domain family 7, member a	Mus musculus	116-124
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	46-57	GLI family zinc finger 2	Homo sapiens	188-193
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	34-42
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	116-124
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	GLI family zinc finger 2	Homo sapiens	188-193
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	34-42
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	C-type lectin domain family 7, member a	Mus musculus	116-124
22503982-3	2012	Using the extracellular domain of Dectin-1 as beta-glucan-specific probes, we succeeded in detection of soluble and Dectin-1-reactive beta-glucan discharged from mouse RAW 264.7 and human THP-1 macrophage cell lines as well as mouse peritoneal macrophages, which had phagocytized insoluble beta-glucan particles.	beta-Glucans	134-145	GLI family zinc finger 2	Homo sapiens	188-193
22503982-6	2012	Moreover, reactive oxygen species (ROS) produced by a Cu(2+)/ascorbic acid system solubilized insoluble beta-glucan particles in vitro, and a part of the solubilized beta-glucan was Dectin-1 reactive and biologically active in macrophage activation.	beta-Glucans	166-177	C-type lectin domain family 7, member a	Mus musculus	182-190
22503982-8	2012	These results suggest that degraded but Dectin-1-reactive beta-glucan is discharged from macrophage cells phagocytizing insoluble beta-glucan particles and stimulates not only themselves again but also the other naive phagocytes, leading to the effective elimination of infecting microbes and the ultimate breakdown and inactivation of metabolically resistant beta-glucan.	beta-Glucans	58-69	C-type lectin domain family 7, member a	Mus musculus	40-48
22503982-8	2012	These results suggest that degraded but Dectin-1-reactive beta-glucan is discharged from macrophage cells phagocytizing insoluble beta-glucan particles and stimulates not only themselves again but also the other naive phagocytes, leading to the effective elimination of infecting microbes and the ultimate breakdown and inactivation of metabolically resistant beta-glucan.	beta-Glucans	130-141	C-type lectin domain family 7, member a	Mus musculus	40-48
22503982-8	2012	These results suggest that degraded but Dectin-1-reactive beta-glucan is discharged from macrophage cells phagocytizing insoluble beta-glucan particles and stimulates not only themselves again but also the other naive phagocytes, leading to the effective elimination of infecting microbes and the ultimate breakdown and inactivation of metabolically resistant beta-glucan.	beta-Glucans	130-141	C-type lectin domain family 7, member a	Mus musculus	40-48
22543832-1	2012	The recognition of beta-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses.	beta-Glucans	19-31	C-type lectin domain family 7, member a	Mus musculus	35-43
22023339-5	2012	Our previous study indicated that LL37 might interact with the cell-wall beta-1,3-exoglucanase Xog1p, which is involved in cell-wall beta-glucan metabolism, and consequently the binding of LL37 or hBD-3 to Xog1p might cause the decrease in adhesion.	beta-Glucans	133-144	cathelicidin antimicrobial peptide	Homo sapiens	34-38
22430139-3	2012	beta-(1,3)-D-glucan with beta-(1,6) branches (beta-glucan) has been used as a nutritional supplement for many years.	beta-Glucans	46-57	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	25-34
22357741-0	2012	Oat beta-glucan and dietary calcium and phosphorus differentially modify intestinal expression of proinflammatory cytokines and monocarboxylate transporter 1 and cecal morphology in weaned pigs.	beta-Glucans	4-15	MCT1	Sus scrofa	128-157
22357741-4	2012	Dietary beta-glucan upregulated the expression of cecal MCT1 (P &lt; 0.05) by 40% and that of colonic IL-6 (P &lt; 0.05) by 142% compared with the control diet.	beta-Glucans	8-19	MCT1	Sus scrofa	56-60
22357741-4	2012	Dietary beta-glucan upregulated the expression of cecal MCT1 (P &lt; 0.05) by 40% and that of colonic IL-6 (P &lt; 0.05) by 142% compared with the control diet.	beta-Glucans	8-19	interleukin 6	Sus scrofa	102-106
22357741-5	2012	Correlation analysis indicated that cecal MCT1 (r = 0.99, P &lt; 0.001) and colonic IL-6 (r = 0.84, P &lt; 0.05) expression was positively related to luminal butyrate and total SCFA, respectively, indicating that beta-glucan may partly modify gene expression via increased SCFA generation.	beta-Glucans	213-224	MCT1	Sus scrofa	42-46
22357741-5	2012	Correlation analysis indicated that cecal MCT1 (r = 0.99, P &lt; 0.001) and colonic IL-6 (r = 0.84, P &lt; 0.05) expression was positively related to luminal butyrate and total SCFA, respectively, indicating that beta-glucan may partly modify gene expression via increased SCFA generation.	beta-Glucans	213-224	interleukin 6	Sus scrofa	84-88
22467677-0	2012	Editorial: beta-glucans: going through GM-CSF to get to dectin.	beta-Glucans	11-23	colony stimulating factor 2	Homo sapiens	39-45
22023339-5	2012	Our previous study indicated that LL37 might interact with the cell-wall beta-1,3-exoglucanase Xog1p, which is involved in cell-wall beta-glucan metabolism, and consequently the binding of LL37 or hBD-3 to Xog1p might cause the decrease in adhesion.	beta-Glucans	133-144	cathelicidin antimicrobial peptide	Homo sapiens	189-193
22023339-5	2012	Our previous study indicated that LL37 might interact with the cell-wall beta-1,3-exoglucanase Xog1p, which is involved in cell-wall beta-glucan metabolism, and consequently the binding of LL37 or hBD-3 to Xog1p might cause the decrease in adhesion.	beta-Glucans	133-144	defensin beta 103B	Homo sapiens	197-202
22015804-2	2012	Dectin-1 has the ability to recognize fungal beta-glucans, which are carbohydrate PAMPs found predominantly in fungal cell walls.	beta-Glucans	45-57	C-type lectin domain family 7 member A	Bubalus bubalis	0-8
22015804-3	2012	The recognition of fungal beta-glucans by Dectin-1 helps in a variety of cellular responses, like host protection, such as fungal uptake and killing, and the production of inflammatory cytokines and chemokines.	beta-Glucans	26-38	C-type lectin domain family 7 member A	Bubalus bubalis	42-50
22015804-7	2012	The docking investigation of Dectin-1 receptor with beta-glucan suggests that ASP150, ASP113, GLY106, and GLU196 amino acids are the catalytic residues which form a shallow groove in the protein surface and bind to ligand beta-glucan.	beta-Glucans	52-63	C-type lectin domain family 7 member A	Bubalus bubalis	29-37
22015804-7	2012	The docking investigation of Dectin-1 receptor with beta-glucan suggests that ASP150, ASP113, GLY106, and GLU196 amino acids are the catalytic residues which form a shallow groove in the protein surface and bind to ligand beta-glucan.	beta-Glucans	222-233	C-type lectin domain family 7 member A	Bubalus bubalis	29-37
21962774-4	2012	OBJECTIVE: To determine whether AIRE could function in anticandidal innate immune signaling, we investigated an extrathymic role for AIRE in the immune recognition of beta-glucan through the Dectin-1 pathway, which is required for defense against Candida species.	beta-Glucans	167-178	autoimmune regulator	Homo sapiens	133-137
21962774-4	2012	OBJECTIVE: To determine whether AIRE could function in anticandidal innate immune signaling, we investigated an extrathymic role for AIRE in the immune recognition of beta-glucan through the Dectin-1 pathway, which is required for defense against Candida species.	beta-Glucans	167-178	C-type lectin domain containing 7A	Homo sapiens	191-199
22200052-8	2012	TNF-alpha was also measured by stimulating bone-marrow derived macrophages with the beta-1,3-glucan beads, and showed a dose dependent response compared to soluble beta-glucan, insoluble beta-1,3-glucan, uncoated beads, and soluble beta-1,3-glucan mixed with uncoated beads.	beta-Glucans	164-175	tumor necrosis factor	Homo sapiens	0-9
22158618-7	2012	Using FRET reporters, we interrogated the effects of soluble beta-glucan on intracellular and extracellular CR3 structure.	beta-Glucans	61-72	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	108-111
21998275-2	2012	Currently available information indicates that CD5 participates not only in cell-to-cell immune interactions through still poorly defined endogenous ligands expressed on hemopoietic and nonhemopoietic cells but also in recognition of exogenous and highly conserved microbial structures such as fungal beta-glucans.	beta-Glucans	301-313	CD5 molecule	Homo sapiens	47-50
22158618-9	2012	A set of phosphopeptides differentially regulated by beta-glucan in a CR3-dependent manner were identified using functional proteomics and found to be enriched for signaling molecules and proteins involved in transcriptional regulation, mRNA processing, and alternative splicing.	beta-Glucans	53-64	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	70-73
22158618-10	2012	These data confirm that CR3 is a signaling pattern recognition receptor for beta-glucan and represent the first direct evidence of soluble beta-glucan binding and affecting a signaling-competent intermediate CR3 conformation on living cells.	beta-Glucans	76-87	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	24-27
23077535-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that whole beta-glucan particles (WGPs) could activate dendritic cells (DCs) via dectin-1 receptor, and increase the expression of GITRL on DCs in vitro and in vivo.	beta-Glucans	67-78	tumor necrosis factor (ligand) superfamily, member 18	Mus musculus	187-192
21912179-3	2012	Although other beta-glucan structures exist, like beta-(1,6)-glucans, little is known about their antigenic or pro-inflammatory properties.	beta-Glucans	15-26	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	50-59
22057536-0	2012	Neoglycolipid-based "designer" oligosaccharide microarrays to define beta-glucan ligands for Dectin-1.	beta-Glucans	69-80	C-type lectin domain containing 7A	Homo sapiens	93-101
21827290-3	2012	In this study, the effects of the carboxymethylated form of beta-glucan (CM-G) on the lymphocyte population of CCR5 genotype patients with prostate cancer (PCa), undergoing androgen deprivation therapy (ADT) was assessed.	beta-Glucans	60-71	C-C motif chemokine receptor 5	Homo sapiens	111-115
23300776-1	2012	Dectin-1 (CLEC7A) is a C-type lectin receptor that binds to beta-glucans found in fungal cell walls to act as a major pattern recognition receptor (PRR).	beta-Glucans	60-72	C-type lectin domain containing 7A	Homo sapiens	0-8
23300776-1	2012	Dectin-1 (CLEC7A) is a C-type lectin receptor that binds to beta-glucans found in fungal cell walls to act as a major pattern recognition receptor (PRR).	beta-Glucans	60-72	C-type lectin domain containing 7A	Homo sapiens	10-16
23300776-1	2012	Dectin-1 (CLEC7A) is a C-type lectin receptor that binds to beta-glucans found in fungal cell walls to act as a major pattern recognition receptor (PRR).	beta-Glucans	60-72	C-type lectin domain family 4 member D	Homo sapiens	23-45
23077535-7	2012	CONCLUSIONS/SIGNIFICANCE: These findings suggest that particulate beta-glucans can be used as an immunomodulator to stimulate potent T cell-mediated adaptive immunity while down-regulate suppressive immune activity via GITR/GITRL interaction, leading to a more efficient defense mechanism against tumor development.	beta-Glucans	66-78	tumor necrosis factor receptor superfamily, member 18	Mus musculus	219-223
23077535-7	2012	CONCLUSIONS/SIGNIFICANCE: These findings suggest that particulate beta-glucans can be used as an immunomodulator to stimulate potent T cell-mediated adaptive immunity while down-regulate suppressive immune activity via GITR/GITRL interaction, leading to a more efficient defense mechanism against tumor development.	beta-Glucans	66-78	tumor necrosis factor (ligand) superfamily, member 18	Mus musculus	224-229
21672632-5	2011	The results showed that dietary beta-glucan, MOS and their combinations significantly increased TCC, phagocytosis, superoxide anion production and SOD activity of sea cucumbers (P &lt; 0.05).	beta-Glucans	32-43	superoxide dismutase [Mn], mitochondrial	Cucumis sativus	147-150
22952831-5	2012	This leads to an increased activation of beta-glucan-induced pSyk, CARD9 and pIkB-alpha, and an increase in the production of pro-inflammatory cytokines such as IL-6, IL-12, IL-1beta and TNF-alpha.	beta-Glucans	41-52	caspase recruitment domain family member 9	Homo sapiens	67-72
22952831-5	2012	This leads to an increased activation of beta-glucan-induced pSyk, CARD9 and pIkB-alpha, and an increase in the production of pro-inflammatory cytokines such as IL-6, IL-12, IL-1beta and TNF-alpha.	beta-Glucans	41-52	tumor necrosis factor	Homo sapiens	187-196
21642586-0	2011	Fungal allergen beta-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells.	beta-Glucans	16-28	interleukin 6	Homo sapiens	83-87
21642586-4	2011	However, upon exposure of the lungs to fungal allergens, the direct contact of beta-glucans present in the fungus cell wall with lung epithelial cells is sufficient to trigger the rapid synthesis and secretion of IL-6 protein.	beta-Glucans	79-91	interleukin 6	Homo sapiens	213-217
21612412-2	2011	Variation in the extended exon 4-6 region of the yak dectin-1 gene (CLEC7A), which encodes the beta-glucan recognition domain, was investigated using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP).	beta-Glucans	95-106	C-type lectin domain containing 7A	Homo sapiens	53-61
21612412-2	2011	Variation in the extended exon 4-6 region of the yak dectin-1 gene (CLEC7A), which encodes the beta-glucan recognition domain, was investigated using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP).	beta-Glucans	95-106	C-type lectin domain containing 7A	Homo sapiens	68-74
21796149-3	2011	beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs.	beta-Glucans	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
21796149-3	2011	beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs.	beta-Glucans	0-11	interleukin 6	Homo sapiens	54-58
21796149-3	2011	beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs.	beta-Glucans	0-11	interleukin 1 alpha	Homo sapiens	64-73
21796149-4	2011	Well-differentiated NHEKs produced elevated IL-8 levels, whereas ATP, a danger signal, significantly increased IL-8 and IL-6 production, and the pathogen-associated compound, poly(I:C), augmented IL-1alpha production by beta-glucan-stimulated NHEKs.	beta-Glucans	220-231	interleukin 1 alpha	Homo sapiens	196-205
21796149-9	2011	Immunoblotting showed that beta-glucan induced dual phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinase (ERK)1/2), and p38 MAPK in NHEKs; these signaling pathways are known to be associated with dectin-1.	beta-Glucans	27-38	interferon induced protein 44	Homo sapiens	71-74
21796149-9	2011	Immunoblotting showed that beta-glucan induced dual phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinase (ERK)1/2), and p38 MAPK in NHEKs; these signaling pathways are known to be associated with dectin-1.	beta-Glucans	27-38	mitogen-activated protein kinase 3	Homo sapiens	112-116
21796149-9	2011	Immunoblotting showed that beta-glucan induced dual phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinase (ERK)1/2), and p38 MAPK in NHEKs; these signaling pathways are known to be associated with dectin-1.	beta-Glucans	27-38	mitogen-activated protein kinase 1	Homo sapiens	119-165
21796149-9	2011	Immunoblotting showed that beta-glucan induced dual phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinase (ERK)1/2), and p38 MAPK in NHEKs; these signaling pathways are known to be associated with dectin-1.	beta-Glucans	27-38	C-type lectin domain containing 7A	Homo sapiens	248-256
21796149-10	2011	Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs.	beta-Glucans	107-118	mitogen-activated protein kinase 1	Homo sapiens	19-22
21796149-10	2011	Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs.	beta-Glucans	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21796149-12	2011	Dectin-1 is present on NHEKs and may have an important role in cell response to beta-glucan.	beta-Glucans	80-91	C-type lectin domain containing 7A	Homo sapiens	0-8
21628003-2	2011	In the present investigation we report that Toll-like receptor (TLR)/MyD88 signaling pathway was responsible in IS2 beta-glucan-mediated cellular response in RAW264.7 murine macrophages.	beta-Glucans	116-127	toll-like receptor 2	Mus musculus	64-67
21628003-2	2011	In the present investigation we report that Toll-like receptor (TLR)/MyD88 signaling pathway was responsible in IS2 beta-glucan-mediated cellular response in RAW264.7 murine macrophages.	beta-Glucans	116-127	myeloid differentiation primary response gene 88	Mus musculus	69-74
21628003-3	2011	Data revealed that IS2 beta-glucan significantly up-regulated the TLR2/TLR4 expression.	beta-Glucans	23-34	toll-like receptor 2	Mus musculus	66-70
21628003-3	2011	Data revealed that IS2 beta-glucan significantly up-regulated the TLR2/TLR4 expression.	beta-Glucans	23-34	toll-like receptor 4	Mus musculus	71-75
21628003-8	2011	Further examination with MyD88-deficient mice revealed that the MyD88 pathway might play an important role for IS2 beta-glucan-mediated activation of macrophages.	beta-Glucans	115-126	myeloid differentiation primary response gene 88	Mus musculus	25-30
21546004-2	2011	These biophysical data extend the current knowledge of beta-glucans/Dectin-1 interactions and suggest different biological mechanisms in close relation with the size of the saccharidic chain.	beta-Glucans	55-67	C-type lectin domain containing 7A	Homo sapiens	68-76
21443814-6	2011	Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE(2) were increased by the administration of beta-glucan.	beta-Glucans	141-152	heat shock protein 1B	Mus musculus	48-75
21443814-7	2011	beta-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro.	beta-Glucans	0-11	heat shock protein 1B	Mus musculus	53-58
21443814-8	2011	The results of the present study suggest that beta-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin.	beta-Glucans	46-57	heat shock protein 1B	Mus musculus	188-193
21691936-6	2011	beta-glucan administration could enhance dectin1 mRNA and protein expression while downregulating the expression of TLR4.	beta-Glucans	0-11	C-type lectin domain containing 7A	Rattus norvegicus	41-48
21691936-6	2011	beta-glucan administration could enhance dectin1 mRNA and protein expression while downregulating the expression of TLR4.	beta-Glucans	0-11	toll-like receptor 4	Rattus norvegicus	116-120
21691936-7	2011	Level of TNF-alpha, IL-1beta in mammary tissues and serum, MPO, NAGase and iNOs activity in mammary tissues was decreased, but the level of IL-2 in serum was increased by beta-glucan.	beta-Glucans	171-182	interleukin 2	Rattus norvegicus	140-144
21518092-0	2011	Particulate beta-glucan induces TNF-alpha production in wound macrophages via a redox-sensitive NF-kappabeta-dependent pathway.	beta-Glucans	12-23	tumor necrosis factor	Homo sapiens	32-41
21803640-1	2011	Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind beta-glucans, is involved in the recognition of several pathogenic fungi.	beta-Glucans	98-110	C-type lectin domain containing 7A	Homo sapiens	0-8
21803640-1	2011	Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind beta-glucans, is involved in the recognition of several pathogenic fungi.	beta-Glucans	98-110	nectin cell adhesion molecule 1	Homo sapiens	59-62
21688388-0	2011	Diet high in oat beta-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice.	beta-Glucans	17-28	neuropeptide Y	Mus musculus	69-72
21688388-4	2011	The average energy intake (-13%, p&lt;0.05) and body weight gain was lower with increasing beta-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest beta-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.	beta-Glucans	175-186	neuropeptide Y	Mus musculus	256-259
21637907-4	2011	Zymosan, a beta-glucan of yeast cell wall, is a ligand for TLR-2 and dectin-1 and stimulates macrophages to produce proinflammatory mediators such as NO and TNF-alpha.	beta-Glucans	11-22	toll-like receptor 2	Mus musculus	59-64
21402701-7	2011	These results indicate that the selective induction of IL-23 by beta-glucans is explained by the activation of c-Rel associated with Ser-10-histone H3 phosphorylation in the il23a promoter mediated by mitogen- and stress-activated kinase and/or protein kinase A and inhibition of il12a transcription by a mechanism involving activation of several corepressors with the ability to bind TLE and to promote histone deacetylation.	beta-Glucans	64-76	interleukin 23 subunit alpha	Homo sapiens	55-60
21402701-7	2011	These results indicate that the selective induction of IL-23 by beta-glucans is explained by the activation of c-Rel associated with Ser-10-histone H3 phosphorylation in the il23a promoter mediated by mitogen- and stress-activated kinase and/or protein kinase A and inhibition of il12a transcription by a mechanism involving activation of several corepressors with the ability to bind TLE and to promote histone deacetylation.	beta-Glucans	64-76	REL proto-oncogene, NF-kB subunit	Homo sapiens	111-116
21402701-7	2011	These results indicate that the selective induction of IL-23 by beta-glucans is explained by the activation of c-Rel associated with Ser-10-histone H3 phosphorylation in the il23a promoter mediated by mitogen- and stress-activated kinase and/or protein kinase A and inhibition of il12a transcription by a mechanism involving activation of several corepressors with the ability to bind TLE and to promote histone deacetylation.	beta-Glucans	64-76	interleukin 23 subunit alpha	Homo sapiens	174-179
21402701-7	2011	These results indicate that the selective induction of IL-23 by beta-glucans is explained by the activation of c-Rel associated with Ser-10-histone H3 phosphorylation in the il23a promoter mediated by mitogen- and stress-activated kinase and/or protein kinase A and inhibition of il12a transcription by a mechanism involving activation of several corepressors with the ability to bind TLE and to promote histone deacetylation.	beta-Glucans	64-76	interleukin 12A	Homo sapiens	280-285
21434779-0	2011	Dietary beta-glucan regulates the levels of inflammatory factors, inflammatory cytokines, and immunoglobulins in interleukin-10 knockout mice.	beta-Glucans	8-19	interleukin 10	Mus musculus	113-127
21434779-5	2011	IL-10(-/-) mice treated with dietary beta-glucan exhibited less inflammation within the colon.	beta-Glucans	37-48	interleukin 10	Mus musculus	0-5
21434779-7	2011	Also, the expression of pro-inflammatory cytokines was lower in the IL-10(-/-) + beta-glucan mice compared with the IL-10(-/-) mice.	beta-Glucans	81-92	interleukin 10	Mus musculus	68-73
21434779-8	2011	Histological analysis also revealed that administration of dietary beta-glucan in IL-10(-/-) mice reduced colonic tissue damage.	beta-Glucans	67-78	interleukin 10	Mus musculus	82-87
21434779-9	2011	Finally, the expression of the pro-inflammatory cytokine tissue necrosis factor-alpha was significantly lower with dietary beta-glucan treatment in IL-10(-/-) mice.	beta-Glucans	123-134	interleukin 10	Mus musculus	148-153
21434779-10	2011	In conclusion, dietary beta-glucan reduces the inflammation associated with IBD caused by IL-10 deficiency.	beta-Glucans	23-34	interleukin 10	Mus musculus	90-95
21518092-0	2011	Particulate beta-glucan induces TNF-alpha production in wound macrophages via a redox-sensitive NF-kappabeta-dependent pathway.	beta-Glucans	12-23	nuclear factor kappa B subunit 1	Homo sapiens	96-108
21525931-2	2011	Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects beta-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS).	beta-Glucans	158-170	C-type lectin domain containing 7A	Homo sapiens	0-8
21525931-2	2011	Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects beta-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS).	beta-Glucans	158-170	C-type lectin domain containing 7A	Homo sapiens	24-30
21525931-4	2011	In this study we show that, despite its ability to bind both soluble and particulate beta-glucan polymers, Dectin-1 signalling is only activated by particulate beta-glucans, which cluster the receptor in synapse-like structures from which regulatory tyrosine phosphatases CD45 and CD148 (also known as PTPRC and PTPRJ, respectively) are excluded (Supplementary Fig.	beta-Glucans	160-172	C-type lectin domain containing 7A	Homo sapiens	107-115
21147161-7	2011	When head kidney cells were exposed to zymosan or beta-glucan, genes encoding IL-1beta, TNF-alpha, IL-6 and IL-10 became up-regulated.	beta-Glucans	50-61	interleukin-1 beta	Oncorhynchus mykiss	78-86
21147161-7	2011	When head kidney cells were exposed to zymosan or beta-glucan, genes encoding IL-1beta, TNF-alpha, IL-6 and IL-10 became up-regulated.	beta-Glucans	50-61	putative tumour necrosis factor alpha	Oncorhynchus mykiss	88-97
21147161-7	2011	When head kidney cells were exposed to zymosan or beta-glucan, genes encoding IL-1beta, TNF-alpha, IL-6 and IL-10 became up-regulated.	beta-Glucans	50-61	interleukin-6	Oncorhynchus mykiss	99-103
21147161-7	2011	When head kidney cells were exposed to zymosan or beta-glucan, genes encoding IL-1beta, TNF-alpha, IL-6 and IL-10 became up-regulated.	beta-Glucans	50-61	interleukin-10	Oncorhynchus mykiss	108-113
21147161-9	2011	In particular, TNF-alpha induction was considerably slower when stimulated with zymosan or beta-glucan.	beta-Glucans	91-102	putative tumour necrosis factor alpha	Oncorhynchus mykiss	15-24
21296999-1	2011	Dectin-1 is the major receptor for fungal beta-glucans.	beta-Glucans	42-54	C-type lectin domain containing 7A	Homo sapiens	0-8
21310257-0	2011	The role of PI3K/Akt pathway in beta-glucan-induced dendritic cell maturation.	beta-Glucans	32-43	AKT serine/threonine kinase 1	Homo sapiens	17-20
20522489-4	2011	Our results showed that quite similar to silymarin, which is a known antioxidant and radical scavenger, tiny concentration of beta-glucan (138 nM) very successfully protected the hepatocytes against cell lysis and all oxidative stress cytotoxicity endpoints caused by depleted uranium including ROS formation, glutathione depletion, decreased mitochondrial membrane potential, lysosomal membrane rupture and caspase 3 activity increase.	beta-Glucans	126-137	caspase 3	Rattus norvegicus	408-417
21636079-0	2011	Increased expression of mGITRL on D2SC/1 cells by particulate beta-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation.	beta-Glucans	62-73	tumor necrosis factor (ligand) superfamily, member 18	Mus musculus	24-30
21471533-5	2011	RESULTS: The early, but not the later, administration of beta-glucan showed a tendency to induce interleukin (IL)-12 in the ascites, whereas both treatment schedules demonstrated a clear tendency to reduce production of interferon-gamma in the abdominal fluid and had no notable impact on the level of tumor necrosis factor-alpha.	beta-Glucans	57-68	tumor necrosis factor	Mus musculus	302-329
21112338-3	2011	Crystal structures of the carbohydrate-recognition domain from human langerin bound to a series of oligomannose compounds, the blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose residues by Ca(2+) coordination of vicinal hydroxyl groups with similar stereochemistry.	beta-Glucans	168-179	CD207 molecule	Homo sapiens	69-77
21112338-6	2011	Likewise, a beta-glucan fragment, Glcbeta1-3Glcbeta1-3Glc, binds to langerin through the interaction of a single glucose residue with the Ca(2+) site.	beta-Glucans	12-23	CD207 molecule	Homo sapiens	68-76
21636079-0	2011	Increased expression of mGITRL on D2SC/1 cells by particulate beta-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation.	beta-Glucans	62-73	CD4 antigen	Mus musculus	108-111
21636079-5	2011	In this study, we found that particulate yeast-derived beta-glucans could induce the maturation of murine dendritic cell line D2SC/1 cells and increase the expression of mGITRL on D2SC/1 cells via Dectin-1/Syk pathway in a dose dependent manner.	beta-Glucans	55-67	tumor necrosis factor (ligand) superfamily, member 18	Mus musculus	170-176
21636079-5	2011	In this study, we found that particulate yeast-derived beta-glucans could induce the maturation of murine dendritic cell line D2SC/1 cells and increase the expression of mGITRL on D2SC/1 cells via Dectin-1/Syk pathway in a dose dependent manner.	beta-Glucans	55-67	C-type lectin domain family 7, member a	Mus musculus	197-205
21636079-5	2011	In this study, we found that particulate yeast-derived beta-glucans could induce the maturation of murine dendritic cell line D2SC/1 cells and increase the expression of mGITRL on D2SC/1 cells via Dectin-1/Syk pathway in a dose dependent manner.	beta-Glucans	55-67	spleen tyrosine kinase	Mus musculus	206-209
20807707-5	2010	Moreover beta-glucan promotes the expansion of Th17 cells, which is strongly decreased by EP2 and EP4 receptor blockade on DCs.	beta-Glucans	9-20	prostaglandin E receptor 2	Homo sapiens	90-93
20807707-2	2010	Here, we report that beta-glucan, a major fungal PAMP purified from Candida albicans, stimulates human DCs to secrete a pro-Th17 cytokine pattern.	beta-Glucans	21-32	adrenomedullin	Homo sapiens	49-53
21776821-6	2011	Melatonin and melatonin + beta-glucan treatments elevated glutathione (GSH) levels and superoxide dismutase, glutathione peroxidase, and glutathione transferase activities in tumor tissues.	beta-Glucans	26-37	glutathione S-transferase alpha 4	Rattus norvegicus	137-160
24688156-15	2010	In the ASA+beta-glucan group, MDA and NO levels and CAT and GSH-Px activities were found to be significantly lower, while SOD activity was found to be significantly higher, in comparison with the ASA-treated group (all, P &lt; 0.001).	beta-Glucans	11-22	catalase	Rattus norvegicus	52-55
20807707-5	2010	Moreover beta-glucan promotes the expansion of Th17 cells, which is strongly decreased by EP2 and EP4 receptor blockade on DCs.	beta-Glucans	9-20	prostaglandin E receptor 4	Homo sapiens	98-101
20807707-6	2010	Our results highlight a novel role for PGE2 in the regulation of innate and adaptive immune response triggered by recognition of a prominent, highly conserved fungal PAMP such as beta-glucan.	beta-Glucans	179-190	adrenomedullin	Homo sapiens	166-170
20809622-2	2010	The method is composed of swelling the sample with KOH and initial digestion with a lyticase, which is followed by treatment with a mixture of exo-1,3-beta-d-glucanase and beta-glucosidase that converts the beta-glucan to glucose.	beta-Glucans	207-218	exonuclease 1	Homo sapiens	143-148
20816244-7	2010	The only effect of the beta-glucan treatment we observed was a significantly higher IL-1 alpha mRNA expression in the spleen.	beta-Glucans	23-34	interleukin 1 alpha	Sus scrofa	84-94
21036709-3	2010	MATERIALS AND METHODS: The capacity of IL-1 Ra anakinra to reduce IL-1-induced production of IL-6 in order to improve the efficacy of a subsequent booster vaccination with survivin-derived peptides and soluble beta-glucan as adjuvant was tested in colon-26 adenocarcinoma-bearing Balb/c-mice.	beta-Glucans	210-221	interleukin 1 receptor antagonist	Mus musculus	39-46
21036709-3	2010	MATERIALS AND METHODS: The capacity of IL-1 Ra anakinra to reduce IL-1-induced production of IL-6 in order to improve the efficacy of a subsequent booster vaccination with survivin-derived peptides and soluble beta-glucan as adjuvant was tested in colon-26 adenocarcinoma-bearing Balb/c-mice.	beta-Glucans	210-221	interleukin 1 complex	Mus musculus	39-43
21036709-3	2010	MATERIALS AND METHODS: The capacity of IL-1 Ra anakinra to reduce IL-1-induced production of IL-6 in order to improve the efficacy of a subsequent booster vaccination with survivin-derived peptides and soluble beta-glucan as adjuvant was tested in colon-26 adenocarcinoma-bearing Balb/c-mice.	beta-Glucans	210-221	interleukin 6	Mus musculus	93-97
20418177-11	2010	Our findings show that GL inhibits acute and neuropathic pain in mice through mechanisms that involve the inhibition of ionotropic glutamate receptors and the interleukin -1beta pathway.	beta-Glucans	23-25	interleukin 1 beta	Mus musculus	159-177
20418177-12	2010	PERSPECTIVE: This article presents the antinociceptive activity of GL in acute and neuropathic pain with participation of ionotropic glutamate receptors and pro-inflammatory cytokines (interleukin-1beta).	beta-Glucans	67-69	interleukin 1 beta	Mus musculus	185-202
20945493-0	2010	Investigation of beta-glucans binding to human/mouse dectin-1 and associated immunomodulatory effects on two monocyte/macrophage cell lines.	beta-Glucans	17-29	C-type lectin domain family 7, member a	Mus musculus	53-61
20417609-0	2010	Detection of beta-glucans using an amperometric biosensor based on high-affinity interaction between Dectin-1 and beta-glucans.	beta-Glucans	13-25	C-type lectin domain family 7, member a	Mus musculus	101-109
20417609-0	2010	Detection of beta-glucans using an amperometric biosensor based on high-affinity interaction between Dectin-1 and beta-glucans.	beta-Glucans	114-126	C-type lectin domain family 7, member a	Mus musculus	101-109
20417609-2	2010	A sensitive amperometric biosensor for beta-glucans was fabricated by immobilizing Dectin-1 onto Nafion-thionine-gold nanoparticle-chitosan multilayer films to trap its corresponding ligand from sample solution.	beta-Glucans	39-51	C-type lectin domain family 7, member a	Mus musculus	83-91
20626862-0	2010	Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells.	beta-Glucans	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20634518-13	2010	Splenic expression of IL-6 was higher in Leghorns fed the basal or ascorbic acid diets, rather than the beta-glucan or corticosterone diets, whereas the opposite relationship was observed in the Fayoumi line.	beta-Glucans	104-115	interleukin 6	Gallus gallus	22-26
20602335-3	2010	While all mutants investigated showed some alteration in cell surface topography, this alteration was particularly salient in mutants defective in beta-glucan elongation (gas1), chitin synthesis (chs3) and cross-linkages between chitin and beta-glucan (crh1crh2).	beta-Glucans	147-158	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	171-175
20660287-0	2010	Dietary oat beta-glucan reduces peak net glucose flux and insulin production and modulates plasma incretin in portal-vein catheterized grower pigs.	beta-Glucans	12-23	insulin	Sus scrofa	58-65
20660287-10	2010	In conclusion, dietary supplementation of 6% oat beta-glucan concentrate decreased net glucose flux, increased net SCFA flux, and decreased peak apparent insulin production, changes that were associated with GIP and GLP-1 mediation.	beta-Glucans	49-60	insulin	Sus scrofa	154-161
20660287-10	2010	In conclusion, dietary supplementation of 6% oat beta-glucan concentrate decreased net glucose flux, increased net SCFA flux, and decreased peak apparent insulin production, changes that were associated with GIP and GLP-1 mediation.	beta-Glucans	49-60	GIP	Sus scrofa	208-211
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	beta-Glucans	211-223	C-X-C motif chemokine ligand 2	Homo sapiens	112-117
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	beta-Glucans	211-223	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
20617171-4	2010	We found that beta-glucan was highly expressed on germinating conidia and hyphae in the cornea stroma, and that both Dectin-1 and phospho-Syk were up-regulated in infected corneas.	beta-Glucans	14-25	C-type lectin domain family 7, member a	Mus musculus	117-141
19998418-3	2010	The components of PBR are ergosterol peroxide, gamma-aminobutyric acid (GABA) and Beta-glucan.	beta-Glucans	82-93	translocator protein	Homo sapiens	18-21
20617171-5	2010	Additionally, we show that infected Dectin-1(-/-) corneas have impaired IL-1beta and CXCL1/KC production, resulting in diminished cellular infiltration and fungal clearance compared with control mice, especially during infection with clinical isolates expressing high beta-glucan.	beta-Glucans	268-279	C-type lectin domain family 7, member a	Mus musculus	36-44
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	C-type lectin domain family 7, member a	Mus musculus	120-128
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	interleukin 1 beta	Mus musculus	163-171
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	chemokine (C-X-C motif) ligand 1	Mus musculus	177-182
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	interleukin 1 receptor, type I	Mus musculus	204-210
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	myeloid differentiation primary response gene 88	Mus musculus	211-216
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	toll-like receptor 4	Mus musculus	303-307
20140432-3	2010	We previously found that a beta-glucan extract from maitake mushroom Grifola frondosa (MBG) enhanced colony forming unit-granulocyte monocyte (CFU-GM) activity of mouse bone marrow and human hematopoietic progenitor cells (HPC), stimulated G-CSF production and spared HPC from doxorubicin toxicity in vitro.	beta-Glucans	27-38	colony stimulating factor 3	Homo sapiens	240-245
20457757-5	2010	In vivo, C5a receptor (C5aR) deficiency in SKG mice inhibited the differentiation/expansion of Th17 cells after mannan or beta-glucan treatment, and consequently suppressed the development of arthritis.	beta-Glucans	122-133	complement component 5a receptor 1	Mus musculus	9-21
20457757-5	2010	In vivo, C5a receptor (C5aR) deficiency in SKG mice inhibited the differentiation/expansion of Th17 cells after mannan or beta-glucan treatment, and consequently suppressed the development of arthritis.	beta-Glucans	122-133	complement component 5a receptor 1	Mus musculus	23-27
20421639-2	2010	Recognition of beta-glucans is mediated through a membrane-bound pattern recognition receptor called dectin-1, and gene knock-out studies have shown that dectin-1 plays an important role in antifungal immune response in vivo.	beta-Glucans	15-27	C-type lectin domain containing 7A	Homo sapiens	101-109
20421639-10	2010	Furthermore, our results suggest that the lysosomal cathepsin B protease, the formation of reactive oxygen species, and the efflux of potassium are needed for beta-glucan-induced NLRP3 inflammasome activation.	beta-Glucans	159-170	NLR family pyrin domain containing 3	Homo sapiens	179-184
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	C-type lectin domain containing 7A	Homo sapiens	88-96
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	NLR family pyrin domain containing 3	Homo sapiens	113-118
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	interleukin 1 beta	Homo sapiens	145-153
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	interleukin 1 beta	Homo sapiens	177-185
20421639-2	2010	Recognition of beta-glucans is mediated through a membrane-bound pattern recognition receptor called dectin-1, and gene knock-out studies have shown that dectin-1 plays an important role in antifungal immune response in vivo.	beta-Glucans	15-27	C-type lectin domain containing 7A	Homo sapiens	154-162
20421639-4	2010	We show that beta-glucans activate the transcription of the proinflammatory cytokine IL-1beta through a dectin-1-dependent pathway in human macrophages.	beta-Glucans	13-25	interleukin 1 beta	Homo sapiens	85-93
20421639-4	2010	We show that beta-glucans activate the transcription of the proinflammatory cytokine IL-1beta through a dectin-1-dependent pathway in human macrophages.	beta-Glucans	13-25	C-type lectin domain containing 7A	Homo sapiens	104-112
20421639-5	2010	Moreover, dectin-1 receptor associated Syk tyrosine kinase was essential for beta-glucan induced IL-1beta mRNA expression.	beta-Glucans	77-88	C-type lectin domain containing 7A	Homo sapiens	10-18
20421639-5	2010	Moreover, dectin-1 receptor associated Syk tyrosine kinase was essential for beta-glucan induced IL-1beta mRNA expression.	beta-Glucans	77-88	spleen associated tyrosine kinase	Homo sapiens	39-42
20421639-5	2010	Moreover, dectin-1 receptor associated Syk tyrosine kinase was essential for beta-glucan induced IL-1beta mRNA expression.	beta-Glucans	77-88	interleukin 1 beta	Homo sapiens	97-105
20421639-6	2010	In contrast to LPS, beta-glucans also strongly activated the secretion of IL-1beta.	beta-Glucans	20-32	interleukin 1 beta	Homo sapiens	74-82
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	5-16	interleukin 1 beta	Homo sapiens	27-35
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	5-16	interleukin 1 beta	Homo sapiens	180-188
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	151-163	interleukin 1 beta	Homo sapiens	27-35
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	151-163	interleukin 1 beta	Homo sapiens	180-188
20421639-8	2010	RNA interference-mediated gene knockdown experiments demonstrated that cytoplasmic NLRP3 inflammasome is essential for beta-glucan-induced IL-1beta secretion.	beta-Glucans	119-130	NLR family pyrin domain containing 3	Homo sapiens	83-88
20421639-8	2010	RNA interference-mediated gene knockdown experiments demonstrated that cytoplasmic NLRP3 inflammasome is essential for beta-glucan-induced IL-1beta secretion.	beta-Glucans	119-130	interleukin 1 beta	Homo sapiens	139-147
20421639-9	2010	Moreover, our results suggest that beta-glucan-induced NLRP3 inflammasome activation is dependent on the dectin-1/Syk signaling pathway.	beta-Glucans	35-46	NLR family pyrin domain containing 3	Homo sapiens	55-60
20421639-9	2010	Moreover, our results suggest that beta-glucan-induced NLRP3 inflammasome activation is dependent on the dectin-1/Syk signaling pathway.	beta-Glucans	35-46	C-type lectin domain containing 7A	Homo sapiens	105-113
20421639-9	2010	Moreover, our results suggest that beta-glucan-induced NLRP3 inflammasome activation is dependent on the dectin-1/Syk signaling pathway.	beta-Glucans	35-46	spleen associated tyrosine kinase	Homo sapiens	114-117
20410681-9	2010	PDT in combination with each beta-glucan significantly reduced tumor growth (P &lt; 0.05, n = 10) and expression of PCNA (P &lt; 0.001, n = 9), and increased necrosis in tumor tissues (P &lt; 0.001, n = 9).	beta-Glucans	29-40	proliferating cell nuclear antigen	Mus musculus	116-120
20100861-4	2010	In this study we demonstrate that a disruption of the C. albicans extracellular signal-regulated kinase (ERK)-like 1 (CEK1)-mediated MAPK pathway causes enhanced cell wall beta-glucan exposure, triggering immune responses more efficiently than the wild type, as measured by dectin-1-mediated specific binding and human dendritic cell (hDC)- and macrophage-mediated phagocytosis, killing, and activation of intracellular signaling pathways.	beta-Glucans	172-183	histidine decarboxylase	Homo sapiens	335-338
23956643-2	2010	The C-type lectin dectin-1, a beta-glucan receptor, is found on the macrophage and can recognize various beta-glucans.	beta-Glucans	105-117	C-type lectin domain family 7, member a	Mus musculus	18-26
23956643-2	2010	The C-type lectin dectin-1, a beta-glucan receptor, is found on the macrophage and can recognize various beta-glucans.	beta-Glucans	105-117	C-type lectin domain family 7, member a	Mus musculus	30-50
23956643-7	2010	When stimulated with beta-glucans, the macrophage cells increased TNF-alpha expression.	beta-Glucans	21-33	tumor necrosis factor	Mus musculus	66-75
23956643-8	2010	When co-stimulation of the cells with beta-glucan and lipopolysaccharide (LPS), a synergy effect was observed by increased TNF-alpha expression.	beta-Glucans	38-49	tumor necrosis factor	Mus musculus	123-132
23956643-10	2010	However, when co-stimulation occurred with beta-glucan and LPS, the cells showed strong synergistic effects by increased IL-6 expression.	beta-Glucans	43-54	interleukin 6	Mus musculus	121-125
23956643-12	2010	Induction of TNF receptor expression by FACS analysis was synergized only when co-stimulated with beta-glucan and LPS, not with beta-glucan alone.	beta-Glucans	98-109	acyl-CoA synthetase long-chain family member 1	Mus musculus	40-44
20091776-3	2010	Complement receptor-3 (CR3) has initially been implicated in mediating the phagocytosis of both C3bi-op and non-opsonized (nop) zymosan by MO through C3bi and beta-glucan binding sites, respectively.	beta-Glucans	159-170	integrin alpha M	Mus musculus	23-26
20097424-8	2010	Langerin recognizes both mannose and beta-glucans present on fungal cell walls and our data demonstrate that Langerin is the major fungal pathogen receptor on human LCs that recognizes pathogenic and commensal fungi.	beta-Glucans	37-49	CD207 molecule	Homo sapiens	109-117
20065023-1	2010	Dectin-1 is an important macrophage phagocytic receptor recognizing fungal beta-glucans.	beta-Glucans	75-87	C-type lectin domain family 7, member a	Mus musculus	0-8
20097424-5	2010	Our data show that Langerin interacts with both mannan and beta-glucan structures, common cell-wall carbohydrate structures of fungi.	beta-Glucans	59-70	CD207 molecule	Homo sapiens	19-27
20097424-8	2010	Langerin recognizes both mannose and beta-glucans present on fungal cell walls and our data demonstrate that Langerin is the major fungal pathogen receptor on human LCs that recognizes pathogenic and commensal fungi.	beta-Glucans	37-49	CD207 molecule	Homo sapiens	0-8
20684476-6	2010	It is concluded that, beta-glucan can induce Th1 as well asTh2 driven immune responses.	beta-Glucans	22-33	negative elongation factor complex member C/D	Homo sapiens	45-48
19949959-0	2010	TGF-beta and CD23 are involved in nitric oxide production by pulmonary macrophages activated by beta-glucan from Paracoccidioides brasiliensis.	beta-Glucans	96-107	transforming growth factor, beta 1	Mus musculus	0-8
19949959-0	2010	TGF-beta and CD23 are involved in nitric oxide production by pulmonary macrophages activated by beta-glucan from Paracoccidioides brasiliensis.	beta-Glucans	96-107	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	13-17
20026063-3	2010	In the present study, the beta-glucan significantly increased luciferase activity in cells transfected with NFkappaB or AP1, but not STAT1, reporter vector DNA, which contain their binding promoter site.	beta-Glucans	26-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-116
20026063-4	2010	All specific NFkappaB and MAPKs pathway inhibitors (pyrrolidine dithiocarbamate, AG490, U0126, SB203580 and SP600125) remarkably attenuated NO production induced by the beta-glucan.	beta-Glucans	169-180	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-21
20026063-5	2010	Furthermore, Western blot analysis revealed that the stimulation of Raw264.7 cells by beta-glucan induced phosphorylation of IkappaB and the consequent translocation of NFkappaB into the nucleus.	beta-Glucans	86-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-177
20026063-7	2010	All these results indicated that beta-glucan from P. polymyxa JB115 activates macrophages through MAPKs and NFkappaB signaling pathway.	beta-Glucans	33-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-116
19730386-3	2010	We hypothesized that our observation of immune stimulating effects by oat beta-glucan in enterocytes was mediated through the beta-glucan receptor dectin-1.	beta-Glucans	74-85	C-type lectin domain containing 7A	Homo sapiens	147-155
19967081-2	2009	In this study, Aureobasidium-derived soluble branched (1,3-1,6) beta-glucan (Sophy beta-glucan) was checked for natural killer (NK) activity and for the production of IFN-gamma and IL-4 in Leishmania amazonensis infection.	beta-Glucans	64-75	interferon gamma	Mus musculus	167-176
19780951-7	2009	CONCLUSIONS: The novel endoglucanase-producing brewer"s yeast strains with inserted endoglucanase gene and deficient MET10 gene led to reduced content of barley beta-glucans, enhanced filterability and increased sulfur dioxide in fermenting wort.	beta-Glucans	161-173	sulfite reductase subunit alpha	Saccharomyces cerevisiae S288C	117-122
20116659-5	2010	We hypothesized that oat beta-glucan activates the central immune transcription factor NF-kappaB and increased cytokine secretion, as we previously reported immune stimulating effects by oat beta-glucan.	beta-Glucans	25-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
20116659-5	2010	We hypothesized that oat beta-glucan activates the central immune transcription factor NF-kappaB and increased cytokine secretion, as we previously reported immune stimulating effects by oat beta-glucan.	beta-Glucans	191-202	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
20116659-6	2010	We found that mice that were administered oat beta-glucans (n = 8) showed an increased intestinal NF-kappaB transactivation in leukocytes (P = .021) and enterocytes (P = .012), particularly in the proximal part of the small intestine (ileum), as compared to placebo mice (n = 8).	beta-Glucans	46-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
19967081-2	2009	In this study, Aureobasidium-derived soluble branched (1,3-1,6) beta-glucan (Sophy beta-glucan) was checked for natural killer (NK) activity and for the production of IFN-gamma and IL-4 in Leishmania amazonensis infection.	beta-Glucans	64-75	interleukin 4	Mus musculus	181-185
19864674-3	2009	The mutated form of dectin-1 was poorly expressed, did not mediate beta-glucan binding, and led to defective production of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with beta-glucan or Candida albicans.	beta-Glucans	215-226	C-type lectin domain containing 7A	Homo sapiens	20-28
19811837-1	2009	We investigated the role of the beta-glucan receptor, Dectin-1, in the response of human neutrophils to unopsonized Saccharomyces cerevisiae and its major beta-glucan-containing capsular constituent, zymosan.	beta-Glucans	32-43	C-type lectin domain containing 7A	Homo sapiens	54-62
19811837-7	2009	In summary, our data show that Dectin-1, although indispensable for recognition of beta-glucan-bearing particles in mice, is not the major receptor for yeast particles in human neutrophils.	beta-Glucans	83-94	C-type lectin domain family 7, member a	Mus musculus	31-39
19733344-2	2009	The (13)C NMR spectra of the sulfated beta-glucans indicated that the C-6 position was preferentially substituted by the sulfate groups.	beta-Glucans	38-50	complement component 6	Mus musculus	70-73
19716422-11	2009	The involvement of IL-17D during proinflammatory responses was demonstrated by investigating the time-dependent expression profile of IL-17D in head kidney and spleen following intraperitoneal injection of live Aeromonas salmonicida, LPS, and beta-glucan.	beta-Glucans	243-254	interleukin 17d	Danio rerio	19-25
19716422-11	2009	The involvement of IL-17D during proinflammatory responses was demonstrated by investigating the time-dependent expression profile of IL-17D in head kidney and spleen following intraperitoneal injection of live Aeromonas salmonicida, LPS, and beta-glucan.	beta-Glucans	243-254	interleukin 17d	Danio rerio	134-140
19753601-0	2009	Oat beta-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects.	beta-Glucans	4-15	cholecystokinin	Homo sapiens	39-54
19410299-1	2009	The immunopharmacological activities of beta-glucans with a backbone of beta-1,3/beta-1,6-linkages associated with anti-tumor, anti-viral, bacterial and fungal infections have been well documented.	beta-Glucans	40-52	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	72-80
19410299-1	2009	The immunopharmacological activities of beta-glucans with a backbone of beta-1,3/beta-1,6-linkages associated with anti-tumor, anti-viral, bacterial and fungal infections have been well documented.	beta-Glucans	40-52	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	81-89
19410299-3	2009	In this study, the encoding nucleotide for the carbohydrate-recognition domain (CRD) of porcine dectin-1 was sequenced for the first time, and the immunomodulatory functions of a synthetic particulate beta-glucan (p-beta-glucan) were examined.	beta-Glucans	201-212	C-type lectin domain containing 7A	Homo sapiens	96-104
20090882-3	2009	In addition, beta-glucan (100 microg/mL) decreased the expression of Bcl-2 by 0.6 times, whereas the expression of Bax and Caspase-3 were increased by 3.1 and 2.3 times, respectively, compared to untreated control group.	beta-Glucans	13-24	BCL2 apoptosis regulator	Homo sapiens	69-74
20090882-3	2009	In addition, beta-glucan (100 microg/mL) decreased the expression of Bcl-2 by 0.6 times, whereas the expression of Bax and Caspase-3 were increased by 3.1 and 2.3 times, respectively, compared to untreated control group.	beta-Glucans	13-24	caspase 3	Homo sapiens	123-132
20090882-4	2009	Furthermore, the caspase-3 activity in the beta-glucan-treated group was significantly increased compared to those in control group (P &lt; 0.05).	beta-Glucans	43-54	caspase 3	Homo sapiens	17-26
19917449-0	2009	Increases in peptide Y-Y levels following oat beta-glucan ingestion are dose-dependent in overweight adults.	beta-Glucans	46-57	peptide YY	Homo sapiens	13-24
19917449-2	2009	We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of beta-glucan.	beta-Glucans	111-122	peptide YY	Homo sapiens	28-31
19917449-6	2009	An increasing dose of beta-glucan resulted in higher levels of plasma PYY, with significant differences between groups from 2 to 4 hours post test-meal.	beta-Glucans	22-33	peptide YY	Homo sapiens	70-73
19917449-9	2009	There was a significant dose response, with a positive correlation between the grams of beta-glucan and PYY area under the curve (r(2) = 0.994, P = .003).	beta-Glucans	88-99	peptide YY	Homo sapiens	104-107
19917449-10	2009	The optimal dose of beta-glucan appears to lie between 4 and 6 g, with the effects on PYY mediated by viscosity and concentration.	beta-Glucans	20-31	peptide YY	Homo sapiens	86-89
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	DNA nucleotidylexotransferase	Homo sapiens	111-148
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	DNA nucleotidylexotransferase	Homo sapiens	150-153
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	BCL2 apoptosis regulator	Homo sapiens	274-279
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	BCL2 associated X, apoptosis regulator	Homo sapiens	281-284
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	caspase 3	Homo sapiens	290-299
20090882-1	2009	The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity.	beta-Glucans	41-52	caspase 3	Homo sapiens	320-329
19753601-6	2009	beta-Glucan was found to decrease insulin secretion over 2 h (RMANOVA, p = 0.011) in a dose responsive manner from 2.16 to 5.68 g per serving (p = 0.007).	beta-Glucans	0-11	insulin	Homo sapiens	34-41
19753601-7	2009	Cholecystokinin levels increased linearly over the same range of beta-glucan concentrations (p = 0.002) in women.	beta-Glucans	65-76	cholecystokinin	Homo sapiens	0-15
19753601-10	2009	beta-Glucan improves satiety and release of cholecystokinin is likely to be part of the mechanism.	beta-Glucans	0-11	cholecystokinin	Homo sapiens	44-59
19573626-0	2009	Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression.	beta-Glucans	8-19	colony stimulating factor 3 (granulocyte)	Mus musculus	91-96
19573626-9	2009	These results reveal a novel function of Maitake beta-glucan that enhances the granulopoiesis and mobilization of granulocytes and their progenitors by stimulating G-CSF production.	beta-Glucans	49-60	colony stimulating factor 3 (granulocyte)	Mus musculus	164-169
19561538-14	2009	Thus, our data suggest that beta-glucan enhances bevacizumab-mediated efficacy and may provide therapeutic benefits for lung cancers with membrane-bound VEGF expression.	beta-Glucans	28-39	vascular endothelial growth factor A	Homo sapiens	153-157
19576635-4	2009	Moreover, the involvement of GATA-3 in Atlantic salmon immune response was demonstrated by investigating the early time dependent expression profile of GATA-3 in spleen and head kidney following intraperitoneal injection of live Aeromonas salmonicida, LPS, and beta-glucan.	beta-Glucans	261-272	transcription factor GATA-3	Salmo salar	29-35
19576635-4	2009	Moreover, the involvement of GATA-3 in Atlantic salmon immune response was demonstrated by investigating the early time dependent expression profile of GATA-3 in spleen and head kidney following intraperitoneal injection of live Aeromonas salmonicida, LPS, and beta-glucan.	beta-Glucans	261-272	transcription factor GATA-3	Salmo salar	152-158
19393720-0	2009	beta-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia.	beta-Glucans	0-11	toll like receptor 2	Homo sapiens	23-27
20360893-1	2009	Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as beta-glucan.	beta-Glucans	199-210	peptide deformylase, mitochondrial	Homo sapiens	22-25
19393720-0	2009	beta-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia.	beta-Glucans	0-11	toll like receptor 4	Homo sapiens	33-37
19393720-4	2009	We previously reported that beta-glucans activate microglia through Dectin-1 without inducing significant amount of cytokines and chemokines.	beta-Glucans	28-40	C-type lectin domain containing 7A	Homo sapiens	68-76
19393720-5	2009	Here, we show that particulate beta-glucans attenuate cytokine production in response to TLR stimulation; this inhibitory activity of beta-glucan is mediated by Dectin-1 and does not require particle internalization.	beta-Glucans	31-43	C-type lectin domain containing 7A	Homo sapiens	161-169
19393720-5	2009	Here, we show that particulate beta-glucans attenuate cytokine production in response to TLR stimulation; this inhibitory activity of beta-glucan is mediated by Dectin-1 and does not require particle internalization.	beta-Glucans	31-42	C-type lectin domain containing 7A	Homo sapiens	161-169
19594491-6	2009	We found that LPS (100 ng/ml) and the used beta-glucan (up to 1000 microg/ml) significantly interacted with each other to reduce TNF-alpha production.	beta-Glucans	43-54	tumor necrosis factor	Homo sapiens	129-138
19619338-0	2009	Candida soluble cell wall beta-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells.	beta-Glucans	26-37	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	50-59
19246104-3	2009	Although a number of receptors are thought to play a role in mediating the biological response to beta-glucans, dectin-1, a C-type lectin, was described as the most important receptor.	beta-Glucans	98-110	C-type lectin domain containing 7A	Homo sapiens	112-120
19515245-6	2009	Based on in vitro studies, beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells.	beta-Glucans	27-39	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	113-116
19563398-0	2009	Effect of GM-CSF on cytokine induction by soluble beta-glucan SCG in vitro in beta-glucan-treated mice.	beta-Glucans	50-61	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	10-16
19563398-0	2009	Effect of GM-CSF on cytokine induction by soluble beta-glucan SCG in vitro in beta-glucan-treated mice.	beta-Glucans	78-89	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	10-16
19563398-13	2009	These results suggested that GM-CSF was closely related with the reactivity of beta-glucan.	beta-Glucans	79-90	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	29-35
19515245-6	2009	Based on in vitro studies, beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells.	beta-Glucans	27-39	toll like receptor 2	Homo sapiens	122-129
19404984-3	2009	Dectin-1 is a PRR that recognizes beta-glucan, a major constituent of many fungi"s outer cell wall.	beta-Glucans	34-45	C-type lectin domain containing 7A	Homo sapiens	0-8
19404984-5	2009	PLCgamma2-deficient DC were unable to expand antigen-specific T cells and induce T(H)1 and T(H)17 differentiation in response to beta-glucan.	beta-Glucans	129-140	phospholipase C gamma 2	Homo sapiens	0-9
19404984-9	2009	We conclude that PLCgamma2 is a crucial signaling mediator that modifies DC gene expression program to activate DC responses to beta-glucan-containing pathogens.	beta-Glucans	128-139	phospholipase C gamma 2	Homo sapiens	17-26
19273561-6	2009	Costimulation of wild-type BMDCs with beta-glucans and specific Toll-like receptor (TLR) ligands resulted in greatly enhanced TNF-alpha production but decreased IL-12p70 production compared with TLR agonists alone.	beta-Glucans	38-50	tumor necrosis factor	Mus musculus	126-135
21291810-7	2009	Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and could therefore provide an additive effect in suppressing hepatocyte cholesterol to that produced by enhancing its depletion with beta-glucans.	beta-Glucans	198-210	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-63
19232731-0	2009	Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.	beta-Glucans	47-58	vav guanine nucleotide exchange factor 1	Homo sapiens	0-4
19232731-3	2009	beta-glucans, the major PAMP present within fungal cell walls, are recognized by Dectin-1, which mediates numerous intracellular events invoked by beta-glucans in various immune cells.	beta-Glucans	0-12	adrenomedullin	Homo sapiens	24-28
19232731-3	2009	beta-glucans, the major PAMP present within fungal cell walls, are recognized by Dectin-1, which mediates numerous intracellular events invoked by beta-glucans in various immune cells.	beta-Glucans	0-12	C-type lectin domain containing 7A	Homo sapiens	81-89
19232731-3	2009	beta-glucans, the major PAMP present within fungal cell walls, are recognized by Dectin-1, which mediates numerous intracellular events invoked by beta-glucans in various immune cells.	beta-Glucans	147-159	adrenomedullin	Homo sapiens	24-28
19232731-3	2009	beta-glucans, the major PAMP present within fungal cell walls, are recognized by Dectin-1, which mediates numerous intracellular events invoked by beta-glucans in various immune cells.	beta-Glucans	147-159	C-type lectin domain containing 7A	Homo sapiens	81-89
19232731-4	2009	Previously, we showed that Dectin-1 mediates phagocytosis of beta-glucan and subsequent superoxide production in microglia.	beta-Glucans	61-72	C-type lectin domain containing 7A	Homo sapiens	27-35
19232731-6	2009	Both Vav1 and PI3K are activated upon stimulation of microglia with beta-glucans, and the two proteins are required for phagocytosis of the glucan particles and for subsequent superoxide production.	beta-Glucans	68-80	vav guanine nucleotide exchange factor 1	Homo sapiens	5-9
19299700-0	2009	Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection.	beta-Glucans	33-46	integrin beta 2	Mus musculus	84-88
19230737-0	2009	The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes.	beta-Glucans	39-49	insulin	Homo sapiens	87-94
19230737-5	2009	CONCLUSIONS: Betaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D.	beta-Glucans	13-23	insulin	Homo sapiens	98-105
19222370-8	2009	N-mannan-linked residues, chitin, and beta-glucan from C. albicans are important for IL-1beta stimulation.	beta-Glucans	38-49	interleukin 1 beta	Homo sapiens	85-93
19205780-7	2009	However, peak and area under the curve of insulin responses were significantly affected by the beta-glucan amount in an inverse linear relationship.	beta-Glucans	95-106	insulin	Homo sapiens	42-49
19205780-8	2009	CONCLUSION: These data suggest that acute consumption of 10 g of beta-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.	beta-Glucans	65-76	insulin	Homo sapiens	146-153
19205780-8	2009	CONCLUSION: These data suggest that acute consumption of 10 g of beta-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.	beta-Glucans	65-76	insulin	Homo sapiens	191-198
19279651-7	2009	Following stimulation with a panel of microbial agents, differences in induced mRNA and protein levels were shown for interleukin (IL)-6 and IL-10 following stimulation with lipopolysaccharide, mannan and beta-glucan.	beta-Glucans	205-216	interleukin 6	Rattus norvegicus	118-136
19279651-7	2009	Following stimulation with a panel of microbial agents, differences in induced mRNA and protein levels were shown for interleukin (IL)-6 and IL-10 following stimulation with lipopolysaccharide, mannan and beta-glucan.	beta-Glucans	205-216	interleukin 10	Rattus norvegicus	141-146
19299700-10	2009	In agreement with this hypothesis, beta-glucan-elicited LB formation was inhibited in leukocytes from 5-LO(-/-), CD18(low) and TLR2(-/-) mice, as well as in leukocytes pretreated with anti-Dectin-1 Ab.	beta-Glucans	35-46	integrin beta 2	Mus musculus	113-117
19299700-10	2009	In agreement with this hypothesis, beta-glucan-elicited LB formation was inhibited in leukocytes from 5-LO(-/-), CD18(low) and TLR2(-/-) mice, as well as in leukocytes pretreated with anti-Dectin-1 Ab.	beta-Glucans	35-46	toll-like receptor 2	Mus musculus	127-131
19299700-0	2009	Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection.	beta-Glucans	33-46	toll-like receptor 2	Mus musculus	90-94
19046775-0	2009	Effect of beta-glucans on an ETEC infection in piglets.	beta-Glucans	10-22	ETEC	Sus scrofa	29-33
19158080-9	2009	Pneumocystis organisms and zymosan A were found to induce AZI overexpression in alveolar macrophages, suggesting that beta-glucan, which is the major component of the Pneumocystis cell wall, induces AZI overexpression.	beta-Glucans	118-129	ornithine decarboxylase antizyme 1	Homo sapiens	58-61
19158080-9	2009	Pneumocystis organisms and zymosan A were found to induce AZI overexpression in alveolar macrophages, suggesting that beta-glucan, which is the major component of the Pneumocystis cell wall, induces AZI overexpression.	beta-Glucans	118-129	ornithine decarboxylase antizyme 1	Homo sapiens	199-202
19046775-1	2009	The effect of orally administered beta-glucans in protecting pigs against an ETEC infection after weaning was analysed in this study.	beta-Glucans	34-46	ETEC	Sus scrofa	77-81
19136564-1	2009	Dectin-1 is a C-type lectin that recognizes beta-glucan in the cell walls of fungi and plays an important role in anti-fungal immunity.	beta-Glucans	44-55	C-type lectin domain containing 7A	Homo sapiens	0-8
19046775-7	2009	This study showed that beta-glucans can protect against an ETEC infection.	beta-Glucans	23-35	ETEC	Sus scrofa	59-63
19046775-9	2009	To our knowledge, this is the first in vivo study, in which the use of beta-glucans as feed ingredient for just-weaned piglets was tested for their protective effects against ETEC infection.	beta-Glucans	71-83	ETEC	Sus scrofa	175-179
19176745-9	2009	In conclusion, viscosity differences in oat beta-glucan in a liquid meal with identical chemical composition strongly influenced not only glucose and insulin responses, but also short-term gut hormone responses, implying the importance of food structure in the modulation of postprandial satiety-related physiology.	beta-Glucans	44-55	insulin	Homo sapiens	150-157
19519162-5	2009	In the ICR mice, CYP3A11 expression was decreased by beta-glucan or IND.	beta-Glucans	53-64	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	17-24
19519162-6	2009	In the early stage of beta-glucan + IND-treatment, 3A11 expression decreased more significantly; when shock was induced, CYP was dramatically decreased.	beta-Glucans	22-33	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	121-124
19519162-8	2009	In contrast, in both strains, CYP2E1 expression did not vary due to beta-glucan or IND, but decreased during sepsis.	beta-Glucans	68-79	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	30-36
19519162-11	2009	The findings here suggest that the beta-glucan + IND combination influenced hepatic cytochrome P450 expression, particularly in the late stage of sepsis.	beta-Glucans	35-46	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	84-99
19323897-0	2009	Insoluble beta-glucan from the cell wall of Candida albicans induces immune responses of human THP-1 monocytes through Dectin-1.	beta-Glucans	10-21	GLI family zinc finger 2	Homo sapiens	95-100
19323897-0	2009	Insoluble beta-glucan from the cell wall of Candida albicans induces immune responses of human THP-1 monocytes through Dectin-1.	beta-Glucans	10-21	C-type lectin domain containing 7A	Homo sapiens	119-127
19323897-2	2009	It has been demonstrated that Dectin-1 as the principal C-type lectin pattern-recognition receptor (PRR) can recognize fungal beta-glucan and induce immune responses.	beta-Glucans	126-137	C-type lectin domain containing 7A	Homo sapiens	30-38
19323897-3	2009	In this study, we sought to clarify whether insoluble beta-glucan from the cell wall of C. albicans (CaIG) could induce immune responses in human THP-1 monocytes (a human acute monocytic leukemia cell line) and to determine the underlying mechanisms.	beta-Glucans	54-65	GLI family zinc finger 2	Homo sapiens	146-151
19178937-7	2009	Induction of CCL20 secretion is not protease or Toll-like receptor 2/4 dependent but, interestingly, relies on beta-glucan moieties within the HDM extract, as evidenced by the ability of other beta-glucans to competitively inhibit its secretion and by the fact that disruption of these structures by treatment of HDM with beta-glucanase significantly reduces subsequent chemokine secretion.	beta-Glucans	111-122	C-C motif chemokine ligand 20	Homo sapiens	13-18
19178937-7	2009	Induction of CCL20 secretion is not protease or Toll-like receptor 2/4 dependent but, interestingly, relies on beta-glucan moieties within the HDM extract, as evidenced by the ability of other beta-glucans to competitively inhibit its secretion and by the fact that disruption of these structures by treatment of HDM with beta-glucanase significantly reduces subsequent chemokine secretion.	beta-Glucans	193-205	C-C motif chemokine ligand 20	Homo sapiens	13-18
19122653-3	2009	Dectin-1, when stimulated by the beta-glucan curdlan or by Candida albicans, induced a second signaling pathway mediated by the serine-threonine kinase Raf-1, which integrated with the Syk pathway at the point of NF-kappaB activation.	beta-Glucans	33-44	C-type lectin domain containing 7A	Homo sapiens	0-8
18837470-0	2009	Modulation of the postprandial phase by beta-glucan in overweight subjects: effects on glucose and insulin kinetics.	beta-Glucans	40-51	insulin	Homo sapiens	99-106
19141631-5	2009	Accordingly, the CD5 ectodomain binds to zymosan but not to purified bacterial cell wall constituents (LPS, lipotheicoic acid, or peptidoglycan), and such binding is specifically competed by beta-glucan but not by mannan.	beta-Glucans	191-202	CD5 antigen	Mus musculus	17-20
19016710-9	2009	RESULTS: At the mRNA level, TLR2 was enhanced by PGN but not by its ligand MALP-2 or by beta-glucan; NOD2 was easily induced by all three ligands; and dectin-1 was enhanced by its ligand beta-glucan.	beta-Glucans	187-198	toll like receptor 2	Homo sapiens	28-32
19016710-9	2009	RESULTS: At the mRNA level, TLR2 was enhanced by PGN but not by its ligand MALP-2 or by beta-glucan; NOD2 was easily induced by all three ligands; and dectin-1 was enhanced by its ligand beta-glucan.	beta-Glucans	187-198	nucleotide binding oligomerization domain containing 2	Homo sapiens	101-105
19016710-9	2009	RESULTS: At the mRNA level, TLR2 was enhanced by PGN but not by its ligand MALP-2 or by beta-glucan; NOD2 was easily induced by all three ligands; and dectin-1 was enhanced by its ligand beta-glucan.	beta-Glucans	187-198	C-type lectin domain containing 7A	Homo sapiens	151-159
18651170-4	2008	NP24 is known to bind beta-glucans and so a linear beta-1,3-glucan molecule has been docked in the interdomain cleft of NP24-I.	beta-Glucans	22-34	protein NP24	Solanum lycopersicum	0-4
19129647-2	2009	Recombinant dectin-1 specifically bound to some beta-glucans, but not to other carbohydrates.	beta-Glucans	48-60	C-type lectin domain containing 7A	Homo sapiens	12-20
19129647-3	2009	The beta-glucan binding of recombinant dectin-1 was inhibited by laminarin, a soluble beta-glucan, and by laminarioligosaccharides, but not by other carbohydrates.	beta-Glucans	4-15	C-type lectin domain containing 7A	Homo sapiens	39-47
19129647-3	2009	The beta-glucan binding of recombinant dectin-1 was inhibited by laminarin, a soluble beta-glucan, and by laminarioligosaccharides, but not by other carbohydrates.	beta-Glucans	86-97	C-type lectin domain containing 7A	Homo sapiens	39-47
19243740-1	2009	Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth.	beta-Glucans	83-94	glial cell line derived neurotrophic factor	Mus musculus	134-137
19347307-5	2009	As discussed in this chapter, this technique based on function has been successfully applied for the identification of dectin-1, the major macrophage receptor involved in the binding and recognition of beta-glucans (Nature 413:36-37, 2001).	beta-Glucans	202-214	C-type lectin domain containing 7A	Homo sapiens	119-127
19399183-0	2009	Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence.	beta-Glucans	19-30	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1	Homo sapiens	72-80
18818389-1	2008	The C-type lectin receptor dectin-1 functions as a pattern recognition receptor for beta-glucans and signals via Syk kinase but independently of the Toll-like receptor (TLR) pathway to regulate expression of innate response genes.	beta-Glucans	84-96	C-type lectin domain family 7, member a	Mus musculus	27-35
18818389-7	2008	The dectin-1/Syk pathway is thus able to couple innate immune recognition of beta-glucans to all branches of the adaptive immune system, including CD4(+) T-helper cells, B cells, and CD8(+) cytotoxic T cells.	beta-Glucans	77-89	C-type lectin domain family 7, member a	Mus musculus	4-12
18818389-7	2008	The dectin-1/Syk pathway is thus able to couple innate immune recognition of beta-glucans to all branches of the adaptive immune system, including CD4(+) T-helper cells, B cells, and CD8(+) cytotoxic T cells.	beta-Glucans	77-89	spleen tyrosine kinase	Mus musculus	13-16
19076344-3	2008	The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease.	beta-Glucans	96-107	C-type lectin domain containing 7A	Homo sapiens	24-32
19076344-3	2008	The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease.	beta-Glucans	225-237	C-type lectin domain containing 7A	Homo sapiens	24-32
19076344-4	2008	Here we review both beta-glucans and their receptor, dectin-1.	beta-Glucans	20-32	C-type lectin domain containing 7A	Homo sapiens	53-61
18802048-5	2008	This sequence of events was replicated by beta-glucan, another substance known to induce IL-23 production.	beta-Glucans	42-53	interleukin 23 subunit alpha	Homo sapiens	89-94
18802048-6	2008	Our results suggest that gliadin and beta-glucan stimulate IL-23 secretion through induction of the IL-1 signaling pathway and reveal for the first time that the IL-1 system regulates IL-23 production.	beta-Glucans	37-48	interleukin 23 subunit alpha	Homo sapiens	59-64
18802048-6	2008	Our results suggest that gliadin and beta-glucan stimulate IL-23 secretion through induction of the IL-1 signaling pathway and reveal for the first time that the IL-1 system regulates IL-23 production.	beta-Glucans	37-48	interleukin 1 beta	Homo sapiens	100-104
18608924-3	2008	One such molecule is Dectin-1, a C-type lectin-like receptor which induces numerous cellular responses upon recognition of fungal beta-glucans.	beta-Glucans	130-142	C-type lectin domain containing 7A	Homo sapiens	21-29
18651170-4	2008	NP24 is known to bind beta-glucans and so a linear beta-1,3-glucan molecule has been docked in the interdomain cleft of NP24-I.	beta-Glucans	22-34	protein NP24	Solanum lycopersicum	120-124
19160131-9	2008	IL-10 levels were significantly increased in the beta GLU group (p &lt; .05).	beta-Glucans	49-57	interleukin 10	Rattus norvegicus	0-5
19160131-10	2008	Superoxide dismutase and catalase levels in the liver tissue were significantly increased in the NAC and beta GLU groups, whereas superoxide dismutase levels were higher in the beta GLU pretreatment group than the NAC pretreatment group (p &lt; 0.05).	beta-Glucans	105-113	catalase	Rattus norvegicus	25-33
18684982-7	2008	Eosinophils use their versatile beta(2) integrin molecule, CD11b, to adhere to a major cell wall component, beta-glucan, but eosinophils do not express other common fungal receptors, such as dectin-1 and lactosylceramide.	beta-Glucans	108-119	integrin subunit alpha M	Homo sapiens	59-64
18684982-8	2008	The I-domain of CD11b is distinctively involved in the eosinophils" interaction with beta-glucan.	beta-Glucans	85-96	integrin subunit alpha M	Homo sapiens	16-21
18729738-0	2008	Highly expressed dectin-1 on bone marrow-derived dendritic cells regulates the sensitivity to beta-glucan in DBA/2 mice.	beta-Glucans	94-105	C-type lectin domain family 7, member a	Mus musculus	17-25
18667041-1	2008	Dectin-1 is a small C-type lectin receptor for fungal cell wall beta-glucan.	beta-Glucans	64-75	C-type lectin domain containing 7A	Rattus norvegicus	0-8
18667041-9	2008	It was also demonstrated that rat dectin-1 is capable of binding fungal beta-glucan and activating nuclear factor-kappa B via Syk and the CARD9/Bcl10-mediated pathway.	beta-Glucans	72-83	C-type lectin domain containing 7A	Rattus norvegicus	34-42
18328447-0	2008	Contribution of dectin-1 and granulocyte macrophage-colony stimulating factor (GM-CSF) to immunomodulating actions of beta-glucan.	beta-Glucans	118-129	C-type lectin domain family 7, member a	Mus musculus	16-24
18490488-3	2008	IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 ligand beta-glucan alone or in combination with TLR2 ligands, mimicking induction by zymosan.	beta-Glucans	226-237	interleukin 23 subunit alpha	Homo sapiens	0-5
18490488-3	2008	IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 ligand beta-glucan alone or in combination with TLR2 ligands, mimicking induction by zymosan.	beta-Glucans	226-237	C-type lectin domain containing 7A	Homo sapiens	210-218
18490488-5	2008	DC priming with interferon (IFN) gamma strongly increased IL-12 production, but was not required for IL-23 production and inhibited IL-23 production induced by beta-glucan.	beta-Glucans	160-171	interleukin 23 subunit alpha	Homo sapiens	132-137
17426742-0	2008	Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects.	beta-Glucans	20-32	insulin	Homo sapiens	52-59
17426742-11	2008	In contrast, muesli with 4 g of beta-glucans significantly (P&lt;0.05) lowered the glucose and insulin responses compared to the reference meal.	beta-Glucans	32-44	insulin	Homo sapiens	95-102
17426742-12	2008	CONCLUSIONS: Muesli enriched with 4 g of beta-glucans reduces postprandial glucose and insulin levels to a breakfast based on high glycaemic index products.	beta-Glucans	41-53	insulin	Homo sapiens	87-94
17426742-13	2008	A total of 4 g of beta-glucans from oats seems to be a critical level for a significant decrease in glucose and insulin responses in healthy people.	beta-Glucans	18-30	insulin	Homo sapiens	112-119
18339771-0	2008	Mobilization of hematopoietic progenitor cells by yeast-derived beta-glucan requires activation of matrix metalloproteinase-9.	beta-Glucans	64-75	matrix metallopeptidase 9	Mus musculus	99-125
18339771-7	2008	However, bone marrow cells from PGG beta-glucan-treated mice secreted abundant matrix metalloproteinase-9 (MMP-9), and PGG beta-glucan-induced HPC mobilization was abrogated in MMP-9 knockout mice.	beta-Glucans	36-47	matrix metallopeptidase 9	Mus musculus	79-105
18339771-7	2008	However, bone marrow cells from PGG beta-glucan-treated mice secreted abundant matrix metalloproteinase-9 (MMP-9), and PGG beta-glucan-induced HPC mobilization was abrogated in MMP-9 knockout mice.	beta-Glucans	36-47	matrix metallopeptidase 9	Mus musculus	107-112
18339771-7	2008	However, bone marrow cells from PGG beta-glucan-treated mice secreted abundant matrix metalloproteinase-9 (MMP-9), and PGG beta-glucan-induced HPC mobilization was abrogated in MMP-9 knockout mice.	beta-Glucans	123-134	matrix metallopeptidase 9	Mus musculus	177-182
18339771-8	2008	Moreover, we demonstrated that both hematopoietic and nonhematopoietic cells contributed to MMP-9 secretion upon PGG beta-glucan treatment.	beta-Glucans	117-128	matrix metallopeptidase 9	Mus musculus	92-97
17698636-1	2008	Human Dectin-1 (hDectin-1) is a member of the C-type lectin-like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates.	beta-Glucans	132-144	C-type lectin domain containing 7A	Homo sapiens	6-14
17698636-1	2008	Human Dectin-1 (hDectin-1) is a member of the C-type lectin-like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates.	beta-Glucans	132-144	C-type lectin domain containing 7A	Homo sapiens	16-25
18328447-0	2008	Contribution of dectin-1 and granulocyte macrophage-colony stimulating factor (GM-CSF) to immunomodulating actions of beta-glucan.	beta-Glucans	118-129	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	29-77
18328447-0	2008	Contribution of dectin-1 and granulocyte macrophage-colony stimulating factor (GM-CSF) to immunomodulating actions of beta-glucan.	beta-Glucans	118-129	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	79-85
18328447-9	2008	On the other hand, controlling the level of endogenous GM-CSF production and/or dectin-1 expression could regulate the reactivity to beta-glucan.	beta-Glucans	133-144	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	55-61
18328447-9	2008	On the other hand, controlling the level of endogenous GM-CSF production and/or dectin-1 expression could regulate the reactivity to beta-glucan.	beta-Glucans	133-144	C-type lectin domain family 7, member a	Mus musculus	80-88
18328447-10	2008	These results indicate that the key factors in the responsiveness to beta-glucan are GM-CSF production and dectin-1 expression.	beta-Glucans	69-80	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	85-91
18328447-10	2008	These results indicate that the key factors in the responsiveness to beta-glucan are GM-CSF production and dectin-1 expression.	beta-Glucans	69-80	C-type lectin domain family 7, member a	Mus musculus	107-115
18301937-8	2008	Different physiological effects of beta-glucan are related to its viscosity, attenuation of postprandial plasma glucose and insulin responses, high transport of bile acids towards lower parts of the intestinal tract and high excretion of bile acids thereby lowering of serum cholesterol levels.	beta-Glucans	35-46	insulin	Homo sapiens	124-131
17785780-1	2007	Dectin-1 is a fungal pattern recognition receptor that binds to beta-glucans and triggers cytokine production by facilitating interaction with TLR2 or by directly activating spleen tyrosine kinase (Syk).	beta-Glucans	64-76	C-type lectin domain family 7, member a	Mus musculus	0-8
18292498-5	2008	In this study, we report that Dectin-1 is indeed expressed on the surface of murine primary microglia, and engagement of the receptor with particulate beta-glucan resulted in an increase in tyrosine phosphorylation of spleen tyrosine kinase, a hallmark feature of the Dectin-1 signaling pathway.	beta-Glucans	151-162	C-type lectin domain family 7, member a	Mus musculus	30-38
18292498-5	2008	In this study, we report that Dectin-1 is indeed expressed on the surface of murine primary microglia, and engagement of the receptor with particulate beta-glucan resulted in an increase in tyrosine phosphorylation of spleen tyrosine kinase, a hallmark feature of the Dectin-1 signaling pathway.	beta-Glucans	151-162	C-type lectin domain family 7, member a	Mus musculus	268-276
18292498-6	2008	Moreover, phagocytosis of beta-glucan particles and subsequent intracellular production of reactive oxygen species were also mediated by Dectin-1.	beta-Glucans	26-37	C-type lectin domain family 7, member a	Mus musculus	137-145
18292498-7	2008	However, unlike in macrophages and dendritic cells, beta-glucan-mediated microglial activation did not result in significant production of cytokines or chemokines; thus, the interaction of microglial Dectin-1 with glucan elicits a unique response.	beta-Glucans	52-63	C-type lectin domain family 7, member a	Mus musculus	200-208
18281559-0	2008	Yeast-derived beta-glucan augments the therapeutic efficacy mediated by anti-vascular endothelial growth factor monoclonal antibody in human carcinoma xenograft models.	beta-Glucans	14-25	vascular endothelial growth factor A	Homo sapiens	77-111
18281559-16	2008	CONCLUSIONS: Yeast-derived beta-glucan can synergize with anti-VEGF monoclonal antibody bevacizumab for the treatment of cancer with membrane-bound VEGF expression.	beta-Glucans	27-38	vascular endothelial growth factor A	Homo sapiens	148-152
18055569-2	2008	Although CD11b/CD18 binds a wide range of ligands, including C3bi and beta-glucan, and transmits outside-in signaling, the mechanism of this signaling responsible for phagocytosis remains obscure.	beta-Glucans	70-81	integrin subunit alpha M	Homo sapiens	9-14
18055569-2	2008	Although CD11b/CD18 binds a wide range of ligands, including C3bi and beta-glucan, and transmits outside-in signaling, the mechanism of this signaling responsible for phagocytosis remains obscure.	beta-Glucans	70-81	integrin subunit beta 2	Homo sapiens	15-19
18175935-8	2008	The results suggest that the beta-glucan-dependent characteristics of Zymosan were not affected by the washing with chloroform/methanol or ethanol, and that TLR2-mediated activity was easily eliminated with these organic solvents.	beta-Glucans	29-40	toll like receptor 2	Homo sapiens	157-161
18008237-0	2007	Immune recognition of Candida albicans beta-glucan by dectin-1.	beta-Glucans	39-50	C-type lectin domain family 7, member a	Mus musculus	54-62
18008237-4	2007	In this study we demonstrate that cytokine production by both human peripheral blood mononuclear cells and murine macrophages is dependent on the recognition of beta-glucans by dectin-1.	beta-Glucans	161-173	C-type lectin domain family 7, member a	Mus musculus	177-185
17761435-5	2007	Stimulation with the proteinases did not alter the PGE2 levels in supernatants from 24-h cultures of PL, however, beta-glucans (100 microg ml(-1)) provoked a large increase in PGE2 levels, which were inhibited after addition of 10 microg ml(-1) of indomethacin, a non-selective inhibitor of COX2 enzymatic activity.	beta-Glucans	114-126	cytochrome c oxidase subunit II	Scophthalmus maximus	291-295
18005717-3	2007	Fungal walls have two kinds of beta-glucan: beta-1,3-glucan and beta-1,6-glucan.	beta-Glucans	31-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	44-52
17671212-0	2007	Combined yeast {beta}-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55.	beta-Glucans	15-28	complement C5a receptor 1	Homo sapiens	80-83
17671212-0	2007	Combined yeast {beta}-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55.	beta-Glucans	15-28	CD55 molecule (Cromer blood group)	Homo sapiens	159-163
17671212-9	2007	We conclude that CD55 suppresses tumor killing by antitumor mAb plus beta-glucan therapy (and, perhaps, in other circumstances).	beta-Glucans	69-80	CD55 molecule (Cromer blood group)	Homo sapiens	17-21
17725857-6	2007	Furthermore, the water-soluble low-molecular-weight beta-glucan (100 mg kg(-1)) prevented the reduction of IL-6 and IL-12 production by splenocytes caused by restraint stress.	beta-Glucans	52-63	interleukin 6	Mus musculus	107-111
17725857-7	2007	These findings suggest that the inhibitory actions of water-soluble low-molecular-weight beta-glucan on the increase in corticosterone level and reduction of NK activity induced by restraint stress may be associated with the abrogation of the IL-6 and IL-12 reduction caused by the stress.	beta-Glucans	89-100	interleukin 6	Mus musculus	243-247
18027205-3	2007	Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.	beta-Glucans	15-26	C-type lectin domain containing 7A	Homo sapiens	30-38
18005717-3	2007	Fungal walls have two kinds of beta-glucan: beta-1,3-glucan and beta-1,6-glucan.	beta-Glucans	31-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	64-72
18005717-5	2007	Examining various beta-glucans for their ability to stimulate human neutrophils, we find that the minor cell wall component beta-1,6-glucan mediates neutrophil activity more efficiently than beta-1,3-glucan, as measured by engulfment, production of reactive oxygen species, and expression of heat shock proteins.	beta-Glucans	18-30	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	124-132
18005717-5	2007	Examining various beta-glucans for their ability to stimulate human neutrophils, we find that the minor cell wall component beta-1,6-glucan mediates neutrophil activity more efficiently than beta-1,3-glucan, as measured by engulfment, production of reactive oxygen species, and expression of heat shock proteins.	beta-Glucans	18-30	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	191-199
17499199-1	2007	There have been a number of reports showing that the crude beta-glucan fraction prepared from various kinds of Basidiomycetes mushrooms acts as anti-cancer and anti-allergic reagent through stimulation of IFN-gamma production.	beta-Glucans	59-70	interferon gamma	Mus musculus	205-214
17485824-0	2007	The suppressive effect of beta-glucan on the production of tumor necrosis factor-alpha in BV2 microglial cells.	beta-Glucans	26-37	tumor necrosis factor	Mus musculus	59-86
17449114-5	2007	The aim of this study was to assess the effects of LPS and beta-glucan on the expression of interleukins (IL-1beta1, IL-1beta2 and IL-6) and the modulated expression of C3 subtypes (C3-1, C3-3 and C3-4) in the rainbow trout (Oncorhynchus mykiss) using real-time RT-PCR.	beta-Glucans	59-70	c3-1	Oncorhynchus mykiss	182-201
17151592-6	2007	RESULTS: Changes from baseline to week 12 in mean peak insulin and incremental area under the insulin curve differed significantly between groups (P=0.037 and 0.034, respectively), with the beta-glucan group showing declines and the control group remaining essentially unchanged.	beta-Glucans	190-201	insulin	Homo sapiens	55-62
17151592-6	2007	RESULTS: Changes from baseline to week 12 in mean peak insulin and incremental area under the insulin curve differed significantly between groups (P=0.037 and 0.034, respectively), with the beta-glucan group showing declines and the control group remaining essentially unchanged.	beta-Glucans	190-201	insulin	Homo sapiens	94-101
17151593-0	2007	The effect of beta-glucan on the glycemic and insulin index.	beta-Glucans	14-25	insulin	Homo sapiens	46-53
17513777-7	2007	Plasma membrane-associated respiratory burst was measured by reduction of ferricytochrome C. Results show that the human PMN oxidative burst response to immobilized beta-glucan is suppressed by addition of beta(1) integrin ligands to the beta-glucan matrix.	beta-Glucans	165-176	integrin subunit beta 1	Homo sapiens	206-222
17513777-7	2007	Plasma membrane-associated respiratory burst was measured by reduction of ferricytochrome C. Results show that the human PMN oxidative burst response to immobilized beta-glucan is suppressed by addition of beta(1) integrin ligands to the beta-glucan matrix.	beta-Glucans	238-249	integrin subunit beta 1	Homo sapiens	206-222
17513777-10	2007	Furthermore, in the absence of matrix, Ab activation of VLA3 or VLA5, but not other beta(1) integrins, also prevented beta-glucan-induced respiratory burst.	beta-Glucans	118-129	integrin subunit alpha 5	Homo sapiens	64-68
17473009-2	2007	Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans.	beta-Glucans	164-176	C-type lectin domain containing 7A	Homo sapiens	41-49
17473009-3	2007	We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice.	beta-Glucans	158-169	C-type lectin domain containing 7A	Homo sapiens	18-26
17473009-4	2007	In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans.	beta-Glucans	138-150	C-type lectin domain containing 7A	Homo sapiens	29-37
17473009-4	2007	In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans.	beta-Glucans	138-150	C-type lectin domain containing 7A	Homo sapiens	125-133
17485824-3	2007	beta-Glucan decreased the production and expression of TNF-alpha.	beta-Glucans	0-11	tumor necrosis factor	Mus musculus	55-64
17485824-5	2007	Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells.	beta-Glucans	6-17	tumor necrosis factor	Mus musculus	48-57
17485824-5	2007	Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells.	beta-Glucans	6-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
17449114-5	2007	The aim of this study was to assess the effects of LPS and beta-glucan on the expression of interleukins (IL-1beta1, IL-1beta2 and IL-6) and the modulated expression of C3 subtypes (C3-1, C3-3 and C3-4) in the rainbow trout (Oncorhynchus mykiss) using real-time RT-PCR.	beta-Glucans	59-70	interleukin-6	Oncorhynchus mykiss	131-135
17485824-2	2007	We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells.	beta-Glucans	30-41	tumor necrosis factor	Mus musculus	63-90
17485824-2	2007	We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells.	beta-Glucans	30-41	tumor necrosis factor	Mus musculus	92-101
17313520-1	2007	Many fungi produce exocellular beta-glucan-degrading enzymes, the beta-glucanases including the noncellulolytic beta-(1,3)- and beta-(1,6)-glucanases, degrading beta-(1,3)- and beta-(1,6)-glucans.	beta-Glucans	31-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	128-137
17414422-12	2007	When beta-glucan was administered, it completely blocked the elevation of TNF-alpha, IL-1beta, and IL-6.	beta-Glucans	5-16	tumor necrosis factor	Rattus norvegicus	74-83
17414422-12	2007	When beta-glucan was administered, it completely blocked the elevation of TNF-alpha, IL-1beta, and IL-6.	beta-Glucans	5-16	interleukin 1 beta	Rattus norvegicus	85-93
17414422-12	2007	When beta-glucan was administered, it completely blocked the elevation of TNF-alpha, IL-1beta, and IL-6.	beta-Glucans	5-16	interleukin 6	Rattus norvegicus	99-103
17414422-14	2007	Animals treated with beta-glucan showed a significant reduction in lung injury score, a marked decrease in ICAM-1 expression, and a significant decrease in MPO levels.	beta-Glucans	21-32	intercellular adhesion molecule 1	Rattus norvegicus	107-113
17414422-14	2007	Animals treated with beta-glucan showed a significant reduction in lung injury score, a marked decrease in ICAM-1 expression, and a significant decrease in MPO levels.	beta-Glucans	21-32	myeloperoxidase	Rattus norvegicus	156-159
17313520-1	2007	Many fungi produce exocellular beta-glucan-degrading enzymes, the beta-glucanases including the noncellulolytic beta-(1,3)- and beta-(1,6)-glucanases, degrading beta-(1,3)- and beta-(1,6)-glucans.	beta-Glucans	31-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	177-186
17230442-7	2007	Soluble beta-glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30 min, p&lt;0.001), and blocked reactive oxygen species production.	beta-Glucans	8-19	C-type lectin domain containing 7A	Homo sapiens	38-46
17368399-1	2007	The deletion of MCD4 leads to an increase in beta-1,6-glucan level and a decrease in glycosylphosphatidylinositol-anchored protein and mannan levels in the cell wall of Saccharomyces cerevisiae, suggesting that mcd4 deletion mutant (mcd4Delta) displays beta-glucans on the cell surface without a mannan cover.	beta-Glucans	253-265	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	16-20
17046204-8	2007	Although no ligand of DCIR has yet been identified, dectin-1 recognizes fungal beta-glucan and its critical role in the biological effects of beta-glucan has been vigorously investigated.	beta-Glucans	142-153	C-type lectin domain containing 7A	Homo sapiens	52-60
17046204-8	2007	Although no ligand of DCIR has yet been identified, dectin-1 recognizes fungal beta-glucan and its critical role in the biological effects of beta-glucan has been vigorously investigated.	beta-Glucans	79-90	C-type lectin domain containing 7A	Homo sapiens	52-60
17208252-3	2007	Neutrophils from zebrafish kidneys released neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) upon stimulation with calcium ionophore, phorbol myristate acetate, and beta-glucan.	beta-Glucans	180-191	myeloid-specific peroxidase	Danio rerio	86-101
17230585-5	2007	As compared to placebo fecal water, beta-glucan enriched fecal water significantly increased IL-8 production in HT29 (5.0%; p = 0.046) and INT407 cells (22.0%; p = 0.028).	beta-Glucans	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17208252-3	2007	Neutrophils from zebrafish kidneys released neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) upon stimulation with calcium ionophore, phorbol myristate acetate, and beta-glucan.	beta-Glucans	180-191	myeloid-specific peroxidase	Danio rerio	103-106
17597024-0	2007	Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice.	beta-Glucans	5-16	heart and neural crest derivatives expressed 2	Mus musculus	57-60
17093103-0	2007	Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production.	beta-Glucans	66-77	colony stimulating factor 3	Homo sapiens	93-130
21783733-10	2007	Furthermore, beta-glucan restored the reduced GSH levels, while it significantly decreased MDA levels and MPO activity.	beta-Glucans	13-24	myeloperoxidase	Rattus norvegicus	106-109
21783733-11	2007	Renal function tests, LDH and TNF-alpha levels, which were increased significantly due to nicotine administration, were decreased with beta-glucan treatment.	beta-Glucans	135-146	tumor necrosis factor	Rattus norvegicus	30-39
17597024-0	2007	Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice.	beta-Glucans	5-16	negative elongation factor complex member C/D, Th1l	Mus musculus	84-87
17597024-2	2007	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3), or to, more recently described dectin-1 a beta-glucan specific receptor, acting mainly on phagocytic cells.	beta-Glucans	33-45	integrin alpha M	Mus musculus	77-103
17597024-2	2007	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3), or to, more recently described dectin-1 a beta-glucan specific receptor, acting mainly on phagocytic cells.	beta-Glucans	33-45	integrin alpha M	Mus musculus	105-108
17597024-7	2007	Conversely, T cells from mice undergoing beta-glucan-enhanced therapy showed increased production of the Th1 cytokine IFNgamma.	beta-Glucans	41-52	negative elongation factor complex member C/D, Th1l	Mus musculus	105-108
17597024-7	2007	Conversely, T cells from mice undergoing beta-glucan-enhanced therapy showed increased production of the Th1 cytokine IFNgamma.	beta-Glucans	41-52	interferon gamma	Mus musculus	118-126
16984120-6	2006	When OVA-SPG was added to macrophages (J774.A1), the amount of the ingested OVA-SPG was increased compared with that of OVA itself, suggesting that Dectin-1 (proinflammatory nonopsonic receptor for beta-glucans) is involved to ingest OVA-SPG.	beta-Glucans	198-210	C-type lectin domain containing 7A	Homo sapiens	148-193
17895603-7	2007	Furthermore, a mAb to the beta-glucan receptor, Dectin-1, significantly (P&lt;0.05) blocked the Sophy beta-glucan induced DNA synthesis in the PBMCs, and Sophy beta-glucan-induced production of IL-8 in the U937 cells.	beta-Glucans	26-37	C-type lectin domain containing 7A	Homo sapiens	48-56
17895603-7	2007	Furthermore, a mAb to the beta-glucan receptor, Dectin-1, significantly (P&lt;0.05) blocked the Sophy beta-glucan induced DNA synthesis in the PBMCs, and Sophy beta-glucan-induced production of IL-8 in the U937 cells.	beta-Glucans	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
17895603-7	2007	Furthermore, a mAb to the beta-glucan receptor, Dectin-1, significantly (P&lt;0.05) blocked the Sophy beta-glucan induced DNA synthesis in the PBMCs, and Sophy beta-glucan-induced production of IL-8 in the U937 cells.	beta-Glucans	102-113	C-type lectin domain containing 7A	Homo sapiens	26-46
17895603-7	2007	Furthermore, a mAb to the beta-glucan receptor, Dectin-1, significantly (P&lt;0.05) blocked the Sophy beta-glucan induced DNA synthesis in the PBMCs, and Sophy beta-glucan-induced production of IL-8 in the U937 cells.	beta-Glucans	102-113	C-type lectin domain containing 7A	Homo sapiens	48-56
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	beta-Glucans	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-10	2007	Studies employing reverse transcriptase-polymerase chain reaction (RT-PCR) showed that Sophy beta-glucan stimulated the expression of IL-8 mRNA in the U937 cells, and that this induction was inhibited by Rottlerin.	beta-Glucans	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
17895603-11	2007	Sophy beta-glucan also blocked the stimulator cell induction of DNA synthesis and IFN-gamma production in the responder cells in a one-way mixed lymphocyte reaction (MLR) using allogenic PBMCs.	beta-Glucans	6-17	interferon gamma	Homo sapiens	82-91
17159982-1	2007	Dectin-1 is a C-type lectin involved in the recognition of beta-glucans found in the cell walls of fungi.	beta-Glucans	59-71	C-type lectin domain family 7, member a	Mus musculus	0-8
17159982-3	2007	In vitro, beta-glucan-induced cytokine production from wild-type dendritic cells and macrophages was abolished in cells homozygous for dectin-1 deficiency ("dectin-1-knockout" cells).	beta-Glucans	10-21	C-type lectin domain family 7, member a	Mus musculus	135-143
17159982-3	2007	In vitro, beta-glucan-induced cytokine production from wild-type dendritic cells and macrophages was abolished in cells homozygous for dectin-1 deficiency ("dectin-1-knockout" cells).	beta-Glucans	10-21	C-type lectin domain family 7, member a	Mus musculus	157-165
17159984-0	2007	Dectin-1 is required for beta-glucan recognition and control of fungal infection.	beta-Glucans	25-36	C-type lectin domain family 7, member a	Mus musculus	0-8
17159984-2	2007	Here we show that deficiency of dectin-1, the myeloid receptor for beta-glucan, rendered mice susceptible to infection with Candida albicans.	beta-Glucans	67-78	C-type lectin domain family 7, member a	Mus musculus	32-40
17159984-5	2007	Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses.	beta-Glucans	49-60	C-type lectin domain family 7, member a	Mus musculus	76-84
16854786-9	2006	The reduced eosinophil infiltration in the SD-1-treated mice could be due to suppression of Th-2 cytokine and eotaxin via interferon-gamma induced by microbial materials, such as beta-glucan.	beta-Glucans	179-190	interferon gamma	Mus musculus	122-138
16908637-9	2006	Intestinal expression of tumor-necrosis factor (TNF)-alpha mRNA was greatest for vitamin C and beta-glucan compared with control and combination, and liver TNF-alpha mRNA expression showed a main effect (P &lt; 0.01) of beta-glucan.	beta-Glucans	95-106	tumor necrosis factor	Sus scrofa	25-58
16908637-12	2006	Intestinal expression of IL-1Ra mRNA was greater (P &lt; 0.05) for vitamin C and beta-glucan treatments compared with the control and combination pigs.	beta-Glucans	81-92	interleukin-1 receptor antagonist protein	Sus scrofa	25-31
16908640-6	2006	The ADG of pigs between d 14 to 28 and d 0 to 28 responded to dietary beta-glucan in a quadratic fashion (P &lt; 0.05), whereas beta-glucan had no effect on ADFI and G:F in any period.	beta-Glucans	70-81	ADG	Sus scrofa	4-7
16908640-10	2006	Pigs treated with beta-glucan had greater ADG in the 14- to 28-d (P = 0.05) and 0-to 28-d (P = 0.035) periods.	beta-Glucans	18-29	ADG	Sus scrofa	42-45
16912650-6	2006	Zymosan particles are rich in beta-glucans and lectin structures that are known to trigger H2O2 production via two major non-toll-like receptor pathogen recognition receptors, comprising the lectin-binding site in the alpha-chain (CD11b) of the complement receptor type 3 and the more recently identified nonclassical C-type lectin, dectin-1.	beta-Glucans	30-42	Fc gamma receptor and transporter	Homo sapiens	218-229
16912650-6	2006	Zymosan particles are rich in beta-glucans and lectin structures that are known to trigger H2O2 production via two major non-toll-like receptor pathogen recognition receptors, comprising the lectin-binding site in the alpha-chain (CD11b) of the complement receptor type 3 and the more recently identified nonclassical C-type lectin, dectin-1.	beta-Glucans	30-42	integrin subunit alpha M	Homo sapiens	231-236
16912650-6	2006	Zymosan particles are rich in beta-glucans and lectin structures that are known to trigger H2O2 production via two major non-toll-like receptor pathogen recognition receptors, comprising the lectin-binding site in the alpha-chain (CD11b) of the complement receptor type 3 and the more recently identified nonclassical C-type lectin, dectin-1.	beta-Glucans	30-42	C-type lectin domain containing 7A	Homo sapiens	333-341
16880608-1	2006	Dectin-1 is a C-type lectin receptor that recognizes fungal beta-glucan, and mediates the production of reactive oxygen species and inflammatory cytokines.	beta-Glucans	60-71	C-type lectin domain family 7, member a	Mus musculus	0-8
16880608-9	2006	These results suggest that N-linked glycosylation on Dectin-1 is essential for the recognition of fungal beta-glucan and subsequent activation of NF-kappaB.	beta-Glucans	105-116	C-type lectin domain family 7, member a	Mus musculus	53-61
16880608-9	2006	These results suggest that N-linked glycosylation on Dectin-1 is essential for the recognition of fungal beta-glucan and subsequent activation of NF-kappaB.	beta-Glucans	105-116	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
16793036-7	2006	On the other hand, administration of beta-glucan following methotrexate abolished the depletion of GSH and inhibited the increases in MDA, MPO activity and collagen content, while the histological analysis revealed that beta-glucan attenuated the tissue damage.	beta-Glucans	37-48	myeloperoxidase	Rattus norvegicus	139-142
16802105-7	2006	To investigate the prevention of Trp-P-2-induced DNA damage, a binding assay was carried out to determine whether BG inactivates the amine via direct binding.	beta-Glucans	114-116	polycystin 2, transient receptor potential cation channel	Homo sapiens	33-40
16844139-0	2006	Soluble Dectin-1 as a tool to detect beta-glucans.	beta-Glucans	37-49	C-type lectin domain containing 7A	Homo sapiens	8-16
16844139-2	2006	Here we have developed a soluble chimeric form of the major mammalian beta-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.	beta-Glucans	198-210	C-type lectin domain containing 7A	Homo sapiens	70-90
16844139-2	2006	Here we have developed a soluble chimeric form of the major mammalian beta-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.	beta-Glucans	198-210	C-type lectin domain containing 7A	Homo sapiens	92-100
16632639-0	2006	Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.	beta-Glucans	79-90	C-type lectin domain family 7, member a	Mus musculus	53-61
16644623-1	2006	OBJECTIVE: Consumption of a meal high in resistant starch or soluble fiber (beta-glucan) decreases peak insulin and glucose concentrations and areas under the curve (AUCs).	beta-Glucans	76-87	insulin	Homo sapiens	104-111
16320779-10	2005	In vitro, the increases of IL-6 and TNF-alpha in culture medium were partially dampened in pigs supplemented with beta-glucan when their lymphocytes were incubated with LPS, whereas the increase of IL-10 was potentiated.	beta-Glucans	114-125	interleukin-6	Sus scrofa	27-31
16622020-9	2006	These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans.	beta-Glucans	193-205	C-type lectin domain family 7, member a	Mus musculus	42-50
16525993-4	2006	Apart from C-dependent cytotoxicity, C activation can lead to complement receptor 3 (CR3)-dependent cellular cytotoxicity (CR3-DCC) by CR3-positive effector cells in the presence of beta-glucan.	beta-Glucans	182-193	DCC netrin 1 receptor	Homo sapiens	127-130
16525993-6	2006	This CR3-DCC was dependent on the binding of the anti-CD55 arm of tumor-bound anti-Ep-CAM*anti-CD55 bi-mAb to effector cell CD55, CR3 priming by beta-glucan and the presence of iC3b on the target cell.	beta-Glucans	145-156	DCC netrin 1 receptor	Homo sapiens	9-12
16525993-6	2006	This CR3-DCC was dependent on the binding of the anti-CD55 arm of tumor-bound anti-Ep-CAM*anti-CD55 bi-mAb to effector cell CD55, CR3 priming by beta-glucan and the presence of iC3b on the target cell.	beta-Glucans	145-156	CD55 molecule (Cromer blood group)	Homo sapiens	54-58
16525993-6	2006	This CR3-DCC was dependent on the binding of the anti-CD55 arm of tumor-bound anti-Ep-CAM*anti-CD55 bi-mAb to effector cell CD55, CR3 priming by beta-glucan and the presence of iC3b on the target cell.	beta-Glucans	145-156	epithelial cell adhesion molecule	Homo sapiens	83-89
16525993-6	2006	This CR3-DCC was dependent on the binding of the anti-CD55 arm of tumor-bound anti-Ep-CAM*anti-CD55 bi-mAb to effector cell CD55, CR3 priming by beta-glucan and the presence of iC3b on the target cell.	beta-Glucans	145-156	CD55 molecule (Cromer blood group)	Homo sapiens	95-99
16525993-6	2006	This CR3-DCC was dependent on the binding of the anti-CD55 arm of tumor-bound anti-Ep-CAM*anti-CD55 bi-mAb to effector cell CD55, CR3 priming by beta-glucan and the presence of iC3b on the target cell.	beta-Glucans	145-156	CD55 molecule (Cromer blood group)	Homo sapiens	95-99
16525993-9	2006	These data imply that the effectiveness of mAb immunotherapy can be improved using anti-tumor antigen*anti-CD55 bi-mAb and beta-glucan, thereby initiating CR3-DCC as an additional effector mechanism that is efficient for eradication of tumor cells with lower antigen expression.	beta-Glucans	123-134	DCC netrin 1 receptor	Homo sapiens	159-162
16407295-9	2006	The results suggest that cytosolic phospholipase A(2) activation triggered by the beta-glucan component of yeast is dependent on the immunoreceptor tyrosine-based activation motif-like domain of dectin-1 and activation of Syk kinase, whereas both TLR2 and Syk kinase regulate COX2 expression.	beta-Glucans	82-93	C-type lectin domain family 7, member a	Mus musculus	195-203
16546702-13	2006	Local treatment with beta-glucan inhibited the increase in MDA and MPO levels and the decrease in GSH in the skin induced by PU, but was less efficient in preventing the damage in visceral organs.	beta-Glucans	21-32	myeloperoxidase	Rattus norvegicus	67-70
16320779-10	2005	In vitro, the increases of IL-6 and TNF-alpha in culture medium were partially dampened in pigs supplemented with beta-glucan when their lymphocytes were incubated with LPS, whereas the increase of IL-10 was potentiated.	beta-Glucans	114-125	tumor necrosis factor	Sus scrofa	36-45
16320779-11	2005	In vivo, dietary beta-glucan attenuated the increase of plasma IL-6 and TNF-alpha, and enhanced the increase of plasma IL-10 when pigs were challenged with LPS.	beta-Glucans	17-28	interleukin-6	Sus scrofa	63-67
16320779-11	2005	In vivo, dietary beta-glucan attenuated the increase of plasma IL-6 and TNF-alpha, and enhanced the increase of plasma IL-10 when pigs were challenged with LPS.	beta-Glucans	17-28	tumor necrosis factor	Sus scrofa	72-81
16320779-11	2005	In vivo, dietary beta-glucan attenuated the increase of plasma IL-6 and TNF-alpha, and enhanced the increase of plasma IL-10 when pigs were challenged with LPS.	beta-Glucans	17-28	interleukin 10	Sus scrofa	119-124
15905548-1	2005	Intravenous and orally administered beta-glucans promote tumor regression and survival by priming granulocyte and macrophage C receptor 3 (CR3, iC3bR and CD11b/CD18) to trigger the cytotoxicity of tumor cells opsonized with iC3b via anti-tumor Abs.	beta-Glucans	36-48	integrin alpha M	Mus musculus	125-137
16244462-0	2005	Promoting protein, a silkworm hemolymph protein promoting in vitro replication of nucleopolyhedrovirus, binds to beta-glucans.	beta-Glucans	113-125	promoting protein	Bombyx mori	0-17
16147975-3	2005	Protection probably was mediated by anti-beta-glucan antibodies as demonstrated by passive transfer of protection to naive mice by the whole immune serum, the immune vaginal fluid, and the affinity-purified anti-beta-glucan IgG fractions, as well as by administration of a beta-glucan-directed IgG2b mAb.	beta-Glucans	41-52	immunoglobulin heavy constant gamma 2B	Mus musculus	294-299
15953565-10	2005	Elevated plasma TNF-alpha levels in septic rats significantly reduced to control levels in beta-glucan treated rats.	beta-Glucans	91-102	tumor necrosis factor	Rattus norvegicus	16-25
15818502-7	2005	MEASUREMENTS AND RESULTS: Rats treated with beta-glucan had fewer circulating neutrophils, more blood monocytes, and higher serum interleukin 6 levels than septic animals.	beta-Glucans	44-55	interleukin 6	Rattus norvegicus	130-143
21783567-12	2005	The increased amounts of MlP-lalpha and TNF-alpha at 0.2mg dose corresponded to the amount of beta-glucan in each particle.	beta-Glucans	94-105	tumor necrosis factor	Mus musculus	40-49
15973050-3	2005	The purified recombinant 6G1 apolipoprotein specifically bound to beta-glucan, but not to chitin, mannan, peptidoglycan, or oligosaccharide chains on glycoproteins.	beta-Glucans	66-77	low molecular mass lipoprotein PBMHP-6	Bombyx mori	25-28
15973050-4	2005	The beta-glucan binding of the recombinant 6G1 was inhibited by laminaribiose and laminarin, a soluble glucan, but not by lipopolysaccharide or insect blood sugar, trehalose at physiological concentration.	beta-Glucans	4-15	low molecular mass lipoprotein PBMHP-6	Bombyx mori	43-46
15905548-1	2005	Intravenous and orally administered beta-glucans promote tumor regression and survival by priming granulocyte and macrophage C receptor 3 (CR3, iC3bR and CD11b/CD18) to trigger the cytotoxicity of tumor cells opsonized with iC3b via anti-tumor Abs.	beta-Glucans	36-48	integrin alpha M	Mus musculus	139-142
15905548-1	2005	Intravenous and orally administered beta-glucans promote tumor regression and survival by priming granulocyte and macrophage C receptor 3 (CR3, iC3bR and CD11b/CD18) to trigger the cytotoxicity of tumor cells opsonized with iC3b via anti-tumor Abs.	beta-Glucans	36-48	integrin alpha M	Mus musculus	154-159
15905548-1	2005	Intravenous and orally administered beta-glucans promote tumor regression and survival by priming granulocyte and macrophage C receptor 3 (CR3, iC3bR and CD11b/CD18) to trigger the cytotoxicity of tumor cells opsonized with iC3b via anti-tumor Abs.	beta-Glucans	36-48	integrin beta 2	Mus musculus	160-164
15863209-2	2005	beta-glucans, naturally occurring glucose polymers, bind to the lectin domain of the leukocyte receptor CR3, prime it for binding to iC3b, and trigger cytotoxicity of iC3b-coated tumor cells.	beta-Glucans	0-12	integrin alpha M	Mus musculus	104-107
15781585-4	2005	Blockade of Dectin-1, a major beta-glucan receptor, can prevent SKG arthritis triggered by beta-glucans, which strongly activate dendritic cells in vitro in a Dectin-1-dependent but Toll-like receptor-independent manner.	beta-Glucans	91-103	C-type lectin domain family 7, member a	Mus musculus	12-20
15816015-1	2005	We identified the C-type-lectin-like receptor, Dectin-1, as the major receptor for fungal beta-glucans on murine macrophages and have demonstrated that it plays a significant role in the cellular response to these carbohydrates.	beta-Glucans	90-102	C-type lectin domain family 7, member a	Mus musculus	47-55
15790516-0	2005	IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucan.	beta-Glucans	138-149	interferon gamma	Mus musculus	0-9
15790516-0	2005	IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucan.	beta-Glucans	138-149	tumor necrosis factor	Mus musculus	42-51
15480753-0	2005	Catalase and alternative oxidase cooperatively regulate programmed cell death induced by beta-glucan elicitor in potato suspension cultures.	beta-Glucans	89-100	LOC102577773	Solanum tuberosum	0-8
15480753-0	2005	Catalase and alternative oxidase cooperatively regulate programmed cell death induced by beta-glucan elicitor in potato suspension cultures.	beta-Glucans	89-100	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	13-32
15480753-1	2005	In potato (Solanum tuberosum L.) suspension cells, the expression of the gene encoding alternative oxidase (AOX) and H2O2 accumulation were induced by treatment with beta-glucan elicitor.	beta-Glucans	166-177	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	87-106
15480753-1	2005	In potato (Solanum tuberosum L.) suspension cells, the expression of the gene encoding alternative oxidase (AOX) and H2O2 accumulation were induced by treatment with beta-glucan elicitor.	beta-Glucans	166-177	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	108-111
15480753-4	2005	The results demonstrate, for the first time, that not only AOX but also catalase plays a central role in the suppression of mitochondrial deltapsi(m) breakdown and PCD induced by beta-glucan elicitor.	beta-Glucans	179-190	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	59-62
15480753-4	2005	The results demonstrate, for the first time, that not only AOX but also catalase plays a central role in the suppression of mitochondrial deltapsi(m) breakdown and PCD induced by beta-glucan elicitor.	beta-Glucans	179-190	LOC102577773	Solanum tuberosum	72-80
15781585-4	2005	Blockade of Dectin-1, a major beta-glucan receptor, can prevent SKG arthritis triggered by beta-glucans, which strongly activate dendritic cells in vitro in a Dectin-1-dependent but Toll-like receptor-independent manner.	beta-Glucans	91-103	C-type lectin domain family 7, member a	Mus musculus	30-50
15781585-4	2005	Blockade of Dectin-1, a major beta-glucan receptor, can prevent SKG arthritis triggered by beta-glucans, which strongly activate dendritic cells in vitro in a Dectin-1-dependent but Toll-like receptor-independent manner.	beta-Glucans	91-103	C-type lectin domain family 7, member a	Mus musculus	159-167
15784984-4	2005	NMR analysis indicated that the beta-glucan oligomer (DP&gt;/=8) has an average DP value of 13, and its ratio of beta-1,3- to beta-1,6-linkages in glucopyranose units was estimated to be 1.3:1.	beta-Glucans	32-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	113-121
15784984-4	2005	NMR analysis indicated that the beta-glucan oligomer (DP&gt;/=8) has an average DP value of 13, and its ratio of beta-1,3- to beta-1,6-linkages in glucopyranose units was estimated to be 1.3:1.	beta-Glucans	32-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	126-134
15320961-8	2004	We conclude that GM-CSF is a key molecule for cytokine induction by beta-glucan, and GM-CSF induction by SCG is the specific step in DBA/2 mice in vitro.	beta-Glucans	68-79	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	17-23
15731053-8	2005	RAW 264.7 macrophages overexpressing Dectin-1 produced more cytokines in respond to FKS, live spherules, and purified beta-glucan than did control RAW cells.	beta-Glucans	118-129	C-type lectin domain family 7, member a	Mus musculus	37-45
15507314-0	2004	Beta-glucan enhancement of T cell IFNgamma response in swine.	beta-Glucans	0-11	interferon gamma	Sus scrofa	34-42
15507314-3	2004	We found that soluble high molecular weight beta-glucan could increase IFNgamma-producing cell frequency in a dose-dependent manner in the enzyme-linked immunospot assay (ELISPOT) in the absence of antigenic restimulation.	beta-Glucans	44-55	interferon gamma	Homo sapiens	71-79
15507314-5	2004	In PRRSV-specific IFNgamma ELISPOT, soluble beta-glucan elicited increased PRRSV-specific responses at concentrations from 3.2 to 50 microg/ml, but not at 100 microg/ml, whereas insoluble beta-glucan had no effect.	beta-Glucans	44-55	interferon gamma	Homo sapiens	18-26
15349034-6	2004	Beta-glucan, a common fungal cell wall component, signals through the newly discovered receptor, dectin-1.	beta-Glucans	0-11	C-type lectin domain containing 7A	Homo sapiens	97-105
15316665-0	2004	Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan.	beta-Glucans	116-127	chemokine (C-C motif) ligand 3	Mus musculus	24-34
15316665-0	2004	Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan.	beta-Glucans	116-127	chemokine (C-C motif) ligand 11	Mus musculus	39-46
15316665-8	2004	In contrast, the beta-glucan induced a little MIP-1alpha but considerably higher concentrations of eotaxin within the first four hours; however, the level of neither chemokine was sustained (Fig.	beta-Glucans	17-28	chemokine (C-C motif) ligand 3	Mus musculus	46-56
15316665-8	2004	In contrast, the beta-glucan induced a little MIP-1alpha but considerably higher concentrations of eotaxin within the first four hours; however, the level of neither chemokine was sustained (Fig.	beta-Glucans	17-28	chemokine (C-C motif) ligand 11	Mus musculus	99-106
15300205-9	2004	RESULTS: beta-glucan significantly enhanced chemotaxis toward C5a and suppressed that toward IL-8 in a CR3-dependent fashion.	beta-Glucans	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15300205-10	2004	In the competing chemotactic gradient assays (C5a vs IL-8), beta-glucan further enhanced migration toward C5a while not affecting that toward IL-8.	beta-Glucans	60-71	complement C5a receptor 1	Homo sapiens	46-49
15300205-3	2004	This laboratory previously reported an increase in the chemotactic capacity of PMNs toward fMLP upon ligation of the CR3 LLD with beta-glucan, a CR3 agonist.	beta-Glucans	130-141	formyl peptide receptor 1	Homo sapiens	91-95
15300205-10	2004	In the competing chemotactic gradient assays (C5a vs IL-8), beta-glucan further enhanced migration toward C5a while not affecting that toward IL-8.	beta-Glucans	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15300205-9	2004	RESULTS: beta-glucan significantly enhanced chemotaxis toward C5a and suppressed that toward IL-8 in a CR3-dependent fashion.	beta-Glucans	9-20	complement C5a receptor 1	Homo sapiens	62-65
15300205-10	2004	In the competing chemotactic gradient assays (C5a vs IL-8), beta-glucan further enhanced migration toward C5a while not affecting that toward IL-8.	beta-Glucans	60-71	complement C5a receptor 1	Homo sapiens	106-109
15300205-11	2004	CONCLUSIONS: beta-glucan selectively upregulates PMN chemotaxis toward C5a while suppressing chemotaxis toward IL-8.	beta-Glucans	13-24	complement C5a receptor 1	Homo sapiens	71-74
15300205-11	2004	CONCLUSIONS: beta-glucan selectively upregulates PMN chemotaxis toward C5a while suppressing chemotaxis toward IL-8.	beta-Glucans	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15027124-10	2004	For CACC the presence of CR3-priming beta-glucan seems to be obligatory.	beta-Glucans	37-48	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	25-28
15213161-0	2004	Characterization of beta-glucan recognition site on C-type lectin, dectin 1.	beta-Glucans	20-31	C-type lectin domain containing 7A	Homo sapiens	67-75
15213161-3	2004	In this study we tried to deduce the amino acid residues in dectin 1 responsible for beta-glucan recognition.	beta-Glucans	85-96	C-type lectin domain containing 7A	Homo sapiens	60-68
15213161-5	2004	The binding of SPG to a dectin 1 transfectant was inhibited by pretreatment with other beta-glucans having a (1--&gt;3)-beta-d-glucosyl linkage but not by pretreatment with alpha-glucans.	beta-Glucans	87-99	C-type lectin domain containing 7A	Homo sapiens	24-32
15213161-12	2004	These results suggest that the amino acid sequence W221-I222-H223 is critical for formation of a beta-glucan binding site in the CRD of dectin 1.	beta-Glucans	97-108	C-type lectin domain containing 7A	Homo sapiens	136-144
15134902-0	2004	Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages.	beta-Glucans	17-28	CD80 antigen	Mus musculus	59-63
15134902-0	2004	Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages.	beta-Glucans	17-28	CD86 antigen	Mus musculus	65-69
15134902-0	2004	Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages.	beta-Glucans	17-28	CD274 antigen	Mus musculus	71-76
15134902-8	2004	This study has demonstrated that a microparticulate form of beta-glucan can enhance B7 co-stimulatory molecule expression on macrophages, thereby enabling these antigen-presenting cells to deliver the second signal to T-lymphocytes that express CD28.	beta-Glucans	60-71	CD28 antigen	Mus musculus	245-249
15030604-7	2004	The concentrations of interferon-gamma (IFN-gamma) and nitric oxide (NO) in bronchoalveolar lavage fluid from pigs pre-administered beta-glucan and infected with SIV (group 3) were significantly higher than for any other group at 7 and 10 dpi for IFN-gamma, and at 5, 7 and 10 dpi for NO (P &lt; 0.05).	beta-Glucans	132-143	interferon gamma	Sus scrofa	22-38
14707091-8	2004	Treatment of RAW 264.7 Mphi expressing SIGNR1, which express low levels of betaGR, with beta-glucans had little effect on binding or TNF-alpha production, indicating that there was no absolute requirement for betaGR in this process.	beta-Glucans	88-100	CD209b antigen	Mus musculus	39-45
14742262-0	2004	Effect of osteopontin alleles on beta-glucan-induced granuloma formation in the mouse liver.	beta-Glucans	33-44	secreted phosphoprotein 1	Mus musculus	10-21
14698225-0	2004	Dectin-1 and its role in the recognition of beta-glucans by macrophages.	beta-Glucans	44-56	C-type lectin domain family 7, member a	Mus musculus	0-8
14978021-0	2004	Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms.	beta-Glucans	39-50	secreted phosphoprotein 1	Homo sapiens	0-11
14578352-6	2004	Furthermore, we show that the GBP is composed of two different carbohydrateactive protein domains, one containing the beta-glucan-binding site, and the other related to glucan endoglucosidases of fungal origin.	beta-Glucans	118-129	probable endo-1,3(4)-beta-glucanase ARB_01444	Glycine max	30-33
15482254-3	2004	Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to beta-glucan, through unique mechanisms.	beta-Glucans	146-157	C-type lectin domain containing 7A	Homo sapiens	0-8
14695221-4	2003	beta- Glucan had been shown to function via the iC3b-receptor complement receptor 3 (CR3; CD11b/CD18) thereby enhancing leukocyte killing of tumor cells coated with iC3b via naturally occurring antitumor antibodies.	beta-Glucans	0-12	integrin alpha M	Mus musculus	85-88
14532278-6	2003	These findings show that cooperative engagement of CR3 on both the lectin-like site involved in beta-glucan binding and the I-domain involved in C3bi binding, as it can be observed in the innate immune response, produces AA release, whereas the unique interaction of C3bi-bound IC with the I-domain of CR3, as it may occur in the adaptive immune response, diverts the IC lattice from a productive interaction with FcgammaR linked to AA release.	beta-Glucans	96-107	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	51-54
14695221-4	2003	beta- Glucan had been shown to function via the iC3b-receptor complement receptor 3 (CR3; CD11b/CD18) thereby enhancing leukocyte killing of tumor cells coated with iC3b via naturally occurring antitumor antibodies.	beta-Glucans	0-12	integrin alpha M	Mus musculus	90-95
14695221-4	2003	beta- Glucan had been shown to function via the iC3b-receptor complement receptor 3 (CR3; CD11b/CD18) thereby enhancing leukocyte killing of tumor cells coated with iC3b via naturally occurring antitumor antibodies.	beta-Glucans	0-12	integrin beta 2	Mus musculus	96-100
14695221-10	2003	beta-Glucan enhancement of the mAb tumoricidal response did not occur in mice deficient in either leukocyte CR3 (CD11b(-/-)) or serum C3, confirming the requirement for CR3 on leukocytes and iC3b on tumors.	beta-Glucans	0-11	integrin alpha M	Mus musculus	169-172
14974727-0	2003	Barley beta-glucan lowers serum cholesterol based on the up-regulation of cholesterol 7alpha-hydroxylase activity and mRNA abundance in cholesterol-fed rats.	beta-Glucans	7-18	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	74-104
15049094-2	2003	This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and interferon-gamma (IFN-gamma) production by splenic cells from C57BL/6 female mice.	beta-Glucans	56-67	Fas (TNF receptor superfamily member 6)	Mus musculus	71-90
15049094-5	2003	administration of particulate beta-glucan (20 or 100 micrograms/animal) and in vitro stimulation of splenic cells (20 or 100 micrograms/ml of culture) decreased lymphoproliferation and IFN-gamma production induced by concanavalin A.	beta-Glucans	30-41	Fas (TNF receptor superfamily member 6)	Mus musculus	161-180
15049094-0	2003	Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae.	beta-Glucans	74-85	Fas (TNF receptor superfamily member 6)	Mus musculus	19-38
15049094-5	2003	administration of particulate beta-glucan (20 or 100 micrograms/animal) and in vitro stimulation of splenic cells (20 or 100 micrograms/ml of culture) decreased lymphoproliferation and IFN-gamma production induced by concanavalin A.	beta-Glucans	30-41	interferon gamma	Mus musculus	185-194
15049094-0	2003	Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae.	beta-Glucans	74-85	interferon gamma	Mus musculus	43-59
14568930-1	2003	Dectin-1 is the major macrophage receptor for beta-glucans and generates a proinflammatory response through the recognition of these carbohydrates on fungal pathogens.	beta-Glucans	46-58	C-type lectin domain family 7, member a	Mus musculus	0-8
12444150-1	2002	A lectin function within CD11b mediates both cytotoxic priming of Mac-1/complement receptor type 3 (CR3) by beta-glucan and the formation of transmembrane signaling complexes with GPI-anchored glycoproteins such as CD16b (FcgammaRIIIb).	beta-Glucans	108-119	integrin subunit alpha M	Homo sapiens	25-30
12716885-8	2003	Macrophages from Toll-like receptor 4-deficient and wild type mice produced equivalent amounts of tumor necrosis factor alpha when stimulated with P. carinii beta-glucan.	beta-Glucans	158-169	toll-like receptor 4	Mus musculus	17-37
12716885-8	2003	Macrophages from Toll-like receptor 4-deficient and wild type mice produced equivalent amounts of tumor necrosis factor alpha when stimulated with P. carinii beta-glucan.	beta-Glucans	158-169	tumor necrosis factor	Mus musculus	98-125
12719478-0	2003	Dectin-1 mediates the biological effects of beta-glucans.	beta-Glucans	44-56	C-type lectin domain containing 7A	Homo sapiens	0-8
12719478-1	2003	The ability of fungal-derived beta-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-alpha, is a well characterized phenomenon.	beta-Glucans	30-41	tumor necrosis factor	Homo sapiens	137-170
12719479-3	2003	In this report we have examined how dectin-1, a lectin family receptor for beta-glucans, collaborates with TLRs in recognizing microbes.	beta-Glucans	75-87	C-type lectin domain containing 7A	Homo sapiens	36-44
12719479-6	2003	Dectin-1 expression enhances TLR-mediated activation of nuclear factor kappa B by beta-glucan-containing particles, and in macrophages and dendritic cells dectin-1 and TLRs are synergistic in mediating production of cytokines such as interleukin 12 and tumor necrosis factor alpha.	beta-Glucans	82-93	C-type lectin domain containing 7A	Homo sapiens	0-8
14511144-5	2003	After 4 weeks, average daily gains (ADG) of beta-glucan treated pigs were not different from the controls.	beta-Glucans	44-55	ADG	Sus scrofa	36-39
12567280-6	2003	All three beta-glucans (0.1-1.0 mg/mL) activated the complement system via the alternative pathway, and could cleave human complement C3 under Ca 2+-free gelatin veronal buffered saline.	beta-Glucans	10-22	complement C3	Homo sapiens	123-136
12444150-8	2002	Moreover, treatment with phosphatidylinositol-specific phospholipase C that removed GPI-anchored proteins increased CD11b-specific binding of (125)I-labeled beta-glucan by 3-fold and this was reversed with soluble recombinant uPAR.	beta-Glucans	157-168	integrin subunit alpha M	Homo sapiens	116-121
12444150-8	2002	Moreover, treatment with phosphatidylinositol-specific phospholipase C that removed GPI-anchored proteins increased CD11b-specific binding of (125)I-labeled beta-glucan by 3-fold and this was reversed with soluble recombinant uPAR.	beta-Glucans	157-168	plasminogen activator, urokinase receptor	Homo sapiens	226-230
12444150-9	2002	Conversely, neutrophil activation for generation of Mac-1/CR3/uPAR complexes inhibited CD11b-dependent binding of (125)I-labeled beta-glucan by 75%.	beta-Glucans	129-140	integrin subunit alpha M	Homo sapiens	52-57
12444150-9	2002	Conversely, neutrophil activation for generation of Mac-1/CR3/uPAR complexes inhibited CD11b-dependent binding of (125)I-labeled beta-glucan by 75%.	beta-Glucans	129-140	plasminogen activator, urokinase receptor	Homo sapiens	62-66
12444150-1	2002	A lectin function within CD11b mediates both cytotoxic priming of Mac-1/complement receptor type 3 (CR3) by beta-glucan and the formation of transmembrane signaling complexes with GPI-anchored glycoproteins such as CD16b (FcgammaRIIIb).	beta-Glucans	108-119	integrin subunit alpha M	Homo sapiens	66-98
12444150-9	2002	Conversely, neutrophil activation for generation of Mac-1/CR3/uPAR complexes inhibited CD11b-dependent binding of (125)I-labeled beta-glucan by 75%.	beta-Glucans	129-140	integrin subunit alpha M	Homo sapiens	87-92
12444150-1	2002	A lectin function within CD11b mediates both cytotoxic priming of Mac-1/complement receptor type 3 (CR3) by beta-glucan and the formation of transmembrane signaling complexes with GPI-anchored glycoproteins such as CD16b (FcgammaRIIIb).	beta-Glucans	108-119	Fc gamma receptor IIIb	Homo sapiens	215-220
12444150-4	2002	A role for the Mac-1/CR3 lectin domain and uPAR in mediating H-AFN or L-AFN adhesion was suggested by the inhibition of Mac-1/CR3-dependent adhesion to ICAM-1 or fibrinogen by beta-glucan or anti-uPAR.	beta-Glucans	176-187	integrin subunit alpha M	Homo sapiens	15-20
12444150-4	2002	A role for the Mac-1/CR3 lectin domain and uPAR in mediating H-AFN or L-AFN adhesion was suggested by the inhibition of Mac-1/CR3-dependent adhesion to ICAM-1 or fibrinogen by beta-glucan or anti-uPAR.	beta-Glucans	176-187	plasminogen activator, urokinase receptor	Homo sapiens	43-47
12444150-4	2002	A role for the Mac-1/CR3 lectin domain and uPAR in mediating H-AFN or L-AFN adhesion was suggested by the inhibition of Mac-1/CR3-dependent adhesion to ICAM-1 or fibrinogen by beta-glucan or anti-uPAR.	beta-Glucans	176-187	integrin subunit alpha M	Homo sapiens	120-125
12444150-6	2002	Conversely, Jurkat cell LFA-1 H-AFN-adhesion to ICAM-1 was not associated with uPAR/LFA-1 complexes, any requirement for GPI-anchored glycoproteins, or inhibition by beta-glucan.	beta-Glucans	166-177	integrin subunit beta 2	Homo sapiens	24-29
12444150-7	2002	A single CD11b lectin site for beta-glucan and uPAR was suggested because the binding of either beta-glucan or uPAR to Mac-1/CR3 selectively masked two CD11b epitopes adjacent to the transmembrane domain.	beta-Glucans	31-42	integrin subunit alpha M	Homo sapiens	9-14
12444150-7	2002	A single CD11b lectin site for beta-glucan and uPAR was suggested because the binding of either beta-glucan or uPAR to Mac-1/CR3 selectively masked two CD11b epitopes adjacent to the transmembrane domain.	beta-Glucans	31-42	integrin subunit alpha M	Homo sapiens	119-124
12444150-7	2002	A single CD11b lectin site for beta-glucan and uPAR was suggested because the binding of either beta-glucan or uPAR to Mac-1/CR3 selectively masked two CD11b epitopes adjacent to the transmembrane domain.	beta-Glucans	31-42	integrin subunit alpha M	Homo sapiens	152-157
12433059-4	2002	As expected, LPS induced the secretion of substantial amounts of all measured parameters, whereas only minor amounts of TNFalpha, IL-6, and IL-10 were induced by beta-glucan itself.	beta-Glucans	162-173	tumor necrosis factor	Homo sapiens	120-128
12384807-1	2002	beta-Glucan primes leukocyte CR3 for enhanced cytotoxicity and synergizes with anti-tumor monoclonal antibodies (mAb).	beta-Glucans	0-11	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	29-32
12384807-9	2002	We observed this beta-glucan effect irrespective of antigen (GD2, GD3, CD20, epidermal growth factor-receptor, HER-2), human tumor type (neuroblastoma, melanoma, lymphoma, epidermoid carcinoma and breast carcinoma) or tumor sites (s.c. versus systemic).	beta-Glucans	17-28	GRDX	Homo sapiens	66-69
12384807-9	2002	We observed this beta-glucan effect irrespective of antigen (GD2, GD3, CD20, epidermal growth factor-receptor, HER-2), human tumor type (neuroblastoma, melanoma, lymphoma, epidermoid carcinoma and breast carcinoma) or tumor sites (s.c. versus systemic).	beta-Glucans	17-28	keratin 20	Homo sapiens	71-75
12384807-9	2002	We observed this beta-glucan effect irrespective of antigen (GD2, GD3, CD20, epidermal growth factor-receptor, HER-2), human tumor type (neuroblastoma, melanoma, lymphoma, epidermoid carcinoma and breast carcinoma) or tumor sites (s.c. versus systemic).	beta-Glucans	17-28	epidermal growth factor receptor	Homo sapiens	77-109
12384807-9	2002	We observed this beta-glucan effect irrespective of antigen (GD2, GD3, CD20, epidermal growth factor-receptor, HER-2), human tumor type (neuroblastoma, melanoma, lymphoma, epidermoid carcinoma and breast carcinoma) or tumor sites (s.c. versus systemic).	beta-Glucans	17-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-116
12433059-4	2002	As expected, LPS induced the secretion of substantial amounts of all measured parameters, whereas only minor amounts of TNFalpha, IL-6, and IL-10 were induced by beta-glucan itself.	beta-Glucans	162-173	interleukin 6	Homo sapiens	130-134
12433059-4	2002	As expected, LPS induced the secretion of substantial amounts of all measured parameters, whereas only minor amounts of TNFalpha, IL-6, and IL-10 were induced by beta-glucan itself.	beta-Glucans	162-173	interleukin 10	Homo sapiens	140-145
12433059-5	2002	However, beta-glucan itself induced the production of significant amounts of IL-8 and TF.	beta-Glucans	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	77-88
12470438-7	2002	CONCLUSION: This study demonstrates a sensitized cytotoxic effect of BCNU with beta-glucan in PC-3 cells, which was associated with a drastic (approximately 80%) inactivation of Gly-I.	beta-Glucans	79-90	glyoxalase I	Homo sapiens	178-183
12433059-7	2002	On the other hand, soluble beta-glucan strongly primed LPS stimulation of all parameters, including TNFalpha and IL-6.	beta-Glucans	27-38	tumor necrosis factor	Homo sapiens	100-108
12470438-8	2002	Therefore, the BCNU/beta-glucan combination may help to improve current treatment efficacy by targeting Gly-I, which appears to be critically involved in prostate cancer viability.	beta-Glucans	20-31	glyoxalase I	Homo sapiens	104-109
12433059-7	2002	On the other hand, soluble beta-glucan strongly primed LPS stimulation of all parameters, including TNFalpha and IL-6.	beta-Glucans	27-38	interleukin 6	Homo sapiens	113-117
12006541-2	2002	We tested if (1--&gt;3),(1--&gt;4)-beta-D-glucan (beta-glucan) can synergize with anti-GD2 monoclonal antibody (MoAb) 3F8 (mouse IgG3) in therapy of human neuroblastoma xenografts.	beta-Glucans	50-61	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	129-133
12349948-4	2002	Beta-glucan activated leukocytes significantly more effectively in a particulate than solubilized form in terms of TNF-alpha production by RAW 264.7 cells, hydrogen peroxide production by murine PEC and IL-8 production by human PBMC.	beta-Glucans	0-11	tumor necrosis factor	Mus musculus	115-124
12349948-4	2002	Beta-glucan activated leukocytes significantly more effectively in a particulate than solubilized form in terms of TNF-alpha production by RAW 264.7 cells, hydrogen peroxide production by murine PEC and IL-8 production by human PBMC.	beta-Glucans	0-11	chemokine (C-X-C motif) ligand 15	Mus musculus	203-207
12185837-5	2002	In addition, eight out of 12 fks1ts fks2 delta mutants had altered beta-glucan levels at the permissive temperature: the partial killer resistant FKS1F1258Y N1520D allele was severely affected in both polymers and displayed a 55% reduction in beta-1,6-glucan, while the in vitro hyperactive allele FKS1T605I M761T increased both beta-glucan levels.	beta-Glucans	67-78	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	36-40
12244185-1	2002	We recently identified dectin-1 (betaGR) as a major beta-glucan receptor on leukocytes and demonstrated that it played a significant role in the non-opsonic recognition of soluble and particulate beta-glucans.	beta-Glucans	196-208	C-type lectin domain containing 7A	Homo sapiens	23-40
11456123-11	2001	In conclusion, our study showed that beta-glucans have various effects on the Th1 or Th2-dependent antibody subclasses, in particular, SSG induces the development of Th1 cells via the IL-12 pathway.	beta-Glucans	37-49	negative elongation factor complex member C/D, Th1l	Mus musculus	78-81
11856365-8	2002	Surprisingly, the activity levels of the four isoenzymes and steady-state levels of their transcripts were differently affected after elicitor treatment of soybean cell cultures with a beta-glucan elicitor of Phytophthora sojae, revealing the down-regulation of 4CL1 vs. up-regulation of 4CL3/4.	beta-Glucans	185-196	4-coumarate:coenzyme A ligase	Glycine max	262-266
11856365-8	2002	Surprisingly, the activity levels of the four isoenzymes and steady-state levels of their transcripts were differently affected after elicitor treatment of soybean cell cultures with a beta-glucan elicitor of Phytophthora sojae, revealing the down-regulation of 4CL1 vs. up-regulation of 4CL3/4.	beta-Glucans	185-196	4-coumarate:CoA ligase isoenzyme 3	Glycine max	288-292
11824547-0	2002	Synergistic action of beta-glucan and platelets on interleukin-8 production by human peripheral blood leukocytes.	beta-Glucans	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
11770038-2	2001	Promotion of polymorphonuclear leukocyte (PMN) chemotaxis by beta-glucan towards fMLP or IL-8 gradients demonstrates a fundamental effect on host defenses by pathogenic fungi.	beta-Glucans	61-72	formyl peptide receptor 1	Homo sapiens	81-85
11770038-4	2001	Present findings demonstrate a profound increase in PMN motility by beta-glucan supplementation of a fibronectin substratum in an underagarose migration assay.	beta-Glucans	68-79	fibronectin 1	Homo sapiens	101-112
11770038-9	2001	Migration on beta-glucan-supplemented fibronectin, but not on fibronectin alone, was negatively regulated by protein kinase C (PKC) or cAMP activation.	beta-Glucans	13-24	fibronectin 1	Homo sapiens	38-49
11683960-5	2001	Upon activation with interferon-gamma/lipopolysaccharide (IFN-gamma/LPS), wound macrophages selectively suppressed beta-glucan ingestion, while phagocytosis of zymosan particles was unaffected.	beta-Glucans	115-126	interferon gamma	Rattus norvegicus	21-56
11683960-5	2001	Upon activation with interferon-gamma/lipopolysaccharide (IFN-gamma/LPS), wound macrophages selectively suppressed beta-glucan ingestion, while phagocytosis of zymosan particles was unaffected.	beta-Glucans	115-126	interferon gamma	Rattus norvegicus	58-67
12018461-3	2002	The extensively glycosylated uPAR binds to the same C-terminal lectin domain of CD11b that had previously been shown to prime Mac-1/CR3 for cytotoxic degranulation in response to beta-glucan.	beta-Glucans	179-190	plasminogen activator, urokinase receptor	Homo sapiens	29-33
12018461-3	2002	The extensively glycosylated uPAR binds to the same C-terminal lectin domain of CD11b that had previously been shown to prime Mac-1/CR3 for cytotoxic degranulation in response to beta-glucan.	beta-Glucans	179-190	integrin subunit alpha M	Homo sapiens	80-85
12018461-3	2002	The extensively glycosylated uPAR binds to the same C-terminal lectin domain of CD11b that had previously been shown to prime Mac-1/CR3 for cytotoxic degranulation in response to beta-glucan.	beta-Glucans	179-190	integrin subunit alpha M	Homo sapiens	126-131
12018461-3	2002	The extensively glycosylated uPAR binds to the same C-terminal lectin domain of CD11b that had previously been shown to prime Mac-1/CR3 for cytotoxic degranulation in response to beta-glucan.	beta-Glucans	179-190	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	132-135
12018461-4	2002	uPAR and beta-glucan compete for a lectin site that is near to the CBRM1/23 epitope (residues 943-1047) at the C-terminus of CD11b, and thus the lectin domain is critical to both the adhesion and cytotoxic functions of Mac-1/CR3.	beta-Glucans	9-20	integrin subunit alpha M	Homo sapiens	125-130
12018461-4	2002	uPAR and beta-glucan compete for a lectin site that is near to the CBRM1/23 epitope (residues 943-1047) at the C-terminus of CD11b, and thus the lectin domain is critical to both the adhesion and cytotoxic functions of Mac-1/CR3.	beta-Glucans	9-20	integrin subunit alpha M	Homo sapiens	219-224
12018461-4	2002	uPAR and beta-glucan compete for a lectin site that is near to the CBRM1/23 epitope (residues 943-1047) at the C-terminus of CD11b, and thus the lectin domain is critical to both the adhesion and cytotoxic functions of Mac-1/CR3.	beta-Glucans	9-20	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	225-228
11676011-1	2001	Grifolan, GRN, is a fungal antitumor beta-glucan isolated from Grifola frondosa.	beta-Glucans	37-48	granulin	Mus musculus	10-13
11456123-11	2001	In conclusion, our study showed that beta-glucans have various effects on the Th1 or Th2-dependent antibody subclasses, in particular, SSG induces the development of Th1 cells via the IL-12 pathway.	beta-Glucans	37-49	heart and neural crest derivatives expressed 2	Mus musculus	85-88
11456123-11	2001	In conclusion, our study showed that beta-glucans have various effects on the Th1 or Th2-dependent antibody subclasses, in particular, SSG induces the development of Th1 cells via the IL-12 pathway.	beta-Glucans	37-49	negative elongation factor complex member C/D, Th1l	Mus musculus	166-169
10477568-0	1999	Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).	beta-Glucans	0-11	integrin alpha M	Mus musculus	130-156
11378805-8	2001	Plasma insulin concentrations were, however, 26% lower with beta-glucan during the last 2 h of the 9 h meal ingestion.	beta-Glucans	60-71	insulin	Homo sapiens	7-14
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	70-82	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	206-214
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	140-152	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	94-102
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	140-152	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	107-115
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	140-152	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	206-214
10665778-0	2000	Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonized erythrocytes or soluble beta-glucan.	beta-Glucans	105-116	integrin alpha M	Mus musculus	30-33
10665778-0	2000	Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonized erythrocytes or soluble beta-glucan.	beta-Glucans	105-116	integrin alpha M	Mus musculus	35-40
10665778-0	2000	Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonized erythrocytes or soluble beta-glucan.	beta-Glucans	105-116	integrin beta 2	Mus musculus	41-45
10665778-3	2000	Studies of isolated macrophages have suggested that CR3 is the major receptor mediating capture of either C3-opsonized erythrocytes (E) or beta-glucans.	beta-Glucans	139-151	integrin alpha M	Mus musculus	52-55
11271600-0	2001	Enhanced lysozyme production in Atlantic salmon (Salmo salar L.) macrophages treated with yeast beta-glucan and bacterial lipopolysaccharide.	beta-Glucans	96-107	lyz	Salmo salar	9-17
11271600-1	2001	Atlantic salmon head kidney macrophages grown in the presence of particulate yeast beta-glucan and bacterial lipopolysaccharide (LPS) showed increased production of lysozyme in the culture supernatants compared to non-treated controls.	beta-Glucans	83-94	lyz	Salmo salar	165-173
11271600-6	2001	Macrophages isolated from fish suffering from a non-lethal Ichthyobodo necator infection displayed a highly increased ability to produce lysozyme in response to both beta-glucan and LPS.	beta-Glucans	166-177	lyz	Salmo salar	137-145
11271600-8	2001	The rather late increase in lysozyme production induced by beta-glucan and LPS may thus be explained by stimulation of differentiation of the macrophages in culture eventually combined with direct activation of transcription of the lysozyme gene.	beta-Glucans	59-70	lyz	Salmo salar	28-36
11271600-8	2001	The rather late increase in lysozyme production induced by beta-glucan and LPS may thus be explained by stimulation of differentiation of the macrophages in culture eventually combined with direct activation of transcription of the lysozyme gene.	beta-Glucans	59-70	lyz	Salmo salar	232-240
11906040-0	2001	Pneumocystis carinii beta-glucan induces release of macrophage inflammatory protein-2 from primary rat alveolar epithelial cells via a receptor distinct from CD11b/CD18.	beta-Glucans	21-32	C-X-C motif chemokine ligand 2	Rattus norvegicus	52-85
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	70-82	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	94-102
11150614-1	2000	1,3-1,4-beta-Glucanases (or lichenases, EC 3.2.1.73) hydrolyse linear beta-glucans containing beta-1,3 and beta-1,4 linkages such as cereal beta-glucans and lichenan, with a strict cleavage specificity for beta-1,4 glycosidic bonds on 3-O-substituted glucosyl residues.	beta-Glucans	70-82	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	107-115
10665778-10	2000	In conclusion, Kupffer cell CR3 plays a crucial role in the clearance of both IgM-opsonized E and beta-glucans.	beta-Glucans	98-110	integrin alpha M	Mus musculus	28-31
10477568-0	1999	Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).	beta-Glucans	0-11	integrin alpha M	Mus musculus	158-163
10477568-0	1999	Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).	beta-Glucans	0-11	integrin beta 2	Mus musculus	164-168
10477568-2	1999	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells.	beta-Glucans	33-45	integrin alpha M	Mus musculus	77-108
10477568-2	1999	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells.	beta-Glucans	33-45	integrin alpha M	Mus musculus	124-129
10477568-2	1999	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells.	beta-Glucans	33-45	integrin alpha M	Mus musculus	131-136
10477568-2	1999	In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells.	beta-Glucans	33-45	integrin beta 2	Mus musculus	137-141
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	beta-Glucans	70-81	integrin alpha M	Mus musculus	34-37
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	beta-Glucans	70-81	integrin alpha M	Mus musculus	257-260
10408367-8	1999	This review discusses a novel type of immunotherapy for cancer that uses soluble yeast beta-glucan to override the normal resistance of iC3b-opsonized tumor cells to the cytotoxic activation of phagocyte and NK cell CR3, allowing this important effector mechanism of the C system to function against tumor cells in the same way that it normally functions against bacteria and yeast.	beta-Glucans	87-98	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	216-219
10457157-7	1999	Co-incubation of MSG with mannan or beta-glucan decreased IL-8 release by 48% and 42% respectively, suggesting that MSG stimulates A549 cells in part through carbohydrate moieties.	beta-Glucans	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10358177-0	1999	Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18).	beta-Glucans	71-82	integrin subunit alpha M	Rattus norvegicus	39-44
10358177-0	1999	Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18).	beta-Glucans	71-82	integrin subunit alpha M	Rattus norvegicus	111-116
10358177-8	1999	Lectin activity of rCD11b proteins was evaluated by both flow cytometry with beta-glucan-FITC and radioactive binding assays with [125I]beta-glucan.	beta-Glucans	77-88	integrin subunit alpha M	Rattus norvegicus	19-25
10358177-9	1999	Sf21 cells expressing rCD11b that included the C-terminal region, with or without the I-domain, exhibited lectin activity that was inhibited by unlabeled beta-glucan or anti-CR3 mAbs.	beta-Glucans	154-165	integrin subunit alpha M	Rattus norvegicus	22-28
10352300-3	1999	Neutrophil migration in response to fMLP was assessed using an agarose overlay method with slides precoated with fibronectin (Fn) +/- beta-glucan.	beta-Glucans	134-145	formyl peptide receptor 1	Homo sapiens	36-40
10352300-8	1999	mAb inhibition studies demonstrate that beta-glucan effects this shift toward directed migration through suppression of migration mediated by Mac-1 and very late Ag 5 and enhancement of very late Ag 3-mediated migration.	beta-Glucans	40-51	integrin subunit beta 2	Homo sapiens	142-147
10352300-10	1999	In summary, these data support a novel role for beta-glucan in regulation of beta 1- and beta 2-mediated neutrophil migration on Fn.	beta-Glucans	48-59	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	77-83
10352300-10	1999	In summary, these data support a novel role for beta-glucan in regulation of beta 1- and beta 2-mediated neutrophil migration on Fn.	beta-Glucans	48-59	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
9844058-8	1998	The size of the CR3-dependent respiratory burst stimulated by particulate beta-glucan correlated directly with the expression of CR3 by individual neutrophils.	beta-Glucans	74-85	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	16-19
9933447-4	1999	Previous studies showed that NK cells could be induced to kill iC3b-opsonized tumours with small soluble beta-glucans that bound with high affinity to CR3, bypassing the absence of similar polysaccharides on tumour membranes.	beta-Glucans	105-117	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	151-154
9933447-7	1999	Soluble beta-glucan primed CR3 for killing of iC3b-coated B cells, but autologous class I-bearing targets were 84% more resistant than class I-deficient Daudi cells.	beta-Glucans	8-19	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	27-30
9973505-1	1999	Mouse leukocyte CR3 (Mac-1, alphaMbeta2 integrin) was shown to function as a receptor for beta-glucans in the same way as human CR3.	beta-Glucans	90-102	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	16-19
9973505-1	1999	Mouse leukocyte CR3 (Mac-1, alphaMbeta2 integrin) was shown to function as a receptor for beta-glucans in the same way as human CR3.	beta-Glucans	90-102	integrin subunit beta 2	Homo sapiens	21-26
9973505-8	1999	SZP or beta-glucans primed CR3 of neutrophils, macrophages, and NK cells for cytotoxicity of iC3b-opsonized tumor cells that otherwise did not trigger killing.	beta-Glucans	7-19	integrin alpha M	Mus musculus	27-30
9973505-9	1999	beta-Glucan priming for cytotoxicity was inhibited by anti-CR3 and did not occur with leukocytes from CR3-/- mice.	beta-Glucans	0-11	integrin alpha M	Mus musculus	59-62
9973505-10	1999	The primed state of macrophage and NK cell CR3 remained detectable for 18 to 24 h after pulsing with beta-glucans.	beta-Glucans	101-113	integrin alpha M	Mus musculus	43-46
9973505-11	1999	The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans.	beta-Glucans	53-65	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	34-37
9973505-11	1999	The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans.	beta-Glucans	142-154	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	34-37
9925123-0	1999	Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan.	beta-Glucans	106-117	cholecystokinin	Homo sapiens	0-57
9864222-2	1999	In the present studies, we analyzed the effects of in vivo administration of a soluble immunomodulator, beta-(1,6)-branched beta-(1,3)-glucan (soluble beta-glucan), on toxin-stimulated cytokine production in monocytes and lymphocytes isolated from treated mice.	beta-Glucans	151-162	hemoglobin, beta adult major chain	Mus musculus	104-113
9864222-4	1999	In vitro stimulation of monocytes isolated from soluble beta-glucan-treated mice with LPS also resulted in suppressed TNF-alpha production, while stimulation of these cells with SEB or TSST-1 resulted in suppressed IL-6 and TNF-alpha production compared to that in cells isolated from untreated mice.	beta-Glucans	56-67	tumor necrosis factor	Mus musculus	118-127
9864222-4	1999	In vitro stimulation of monocytes isolated from soluble beta-glucan-treated mice with LPS also resulted in suppressed TNF-alpha production, while stimulation of these cells with SEB or TSST-1 resulted in suppressed IL-6 and TNF-alpha production compared to that in cells isolated from untreated mice.	beta-Glucans	56-67	tumor necrosis factor	Mus musculus	224-233
9864222-5	1999	Thus, the overall cytokine pattern of leukocytes from soluble beta-glucan-treated mice reflects suppressed production of proinflammatory cytokines, especially TNF-alpha.	beta-Glucans	62-73	tumor necrosis factor	Mus musculus	159-168
9844058-8	1998	The size of the CR3-dependent respiratory burst stimulated by particulate beta-glucan correlated directly with the expression of CR3 by individual neutrophils.	beta-Glucans	74-85	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	129-132
9718206-10	1998	Interferon-gamma, interleukin-6 and colony stimulating factor concentrations in sera of indomethacin/beta-glucan-treated mice were significantly elevated.	beta-Glucans	101-112	interferon gamma	Mus musculus	0-16
9718206-10	1998	Interferon-gamma, interleukin-6 and colony stimulating factor concentrations in sera of indomethacin/beta-glucan-treated mice were significantly elevated.	beta-Glucans	101-112	interleukin 6	Mus musculus	18-31
9718206-10	1998	Interferon-gamma, interleukin-6 and colony stimulating factor concentrations in sera of indomethacin/beta-glucan-treated mice were significantly elevated.	beta-Glucans	101-112	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	36-61
9718212-0	1998	Soluble mannan and beta-glucan inhibit the uptake of Malassezia furfur by human monocytic cell line, THP-1.	beta-Glucans	19-30	GLI family zinc finger 2	Homo sapiens	101-106
9718212-5	1998	Yeast mannan and beta-1,3-glucan, random coiled conformer, inhibited the uptake of live and heat-killed M. furfur by THP-1, though dextran T-250, that is alpha-glucan, and schizophyllan (SPG), triple helix conformer of beta-glucan, did not.	beta-Glucans	219-230	GLI family zinc finger 2	Homo sapiens	117-122
21781874-4	1998	The mRNA expression of a number of other inflammatory mediators such as interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and cyclooxygenase-2 was also increased by the exposure to beta-glucan.	beta-Glucans	193-204	interleukin 1 beta	Rattus norvegicus	72-89
21781874-4	1998	The mRNA expression of a number of other inflammatory mediators such as interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and cyclooxygenase-2 was also increased by the exposure to beta-glucan.	beta-Glucans	193-204	interleukin 6	Rattus norvegicus	91-133
21781874-4	1998	The mRNA expression of a number of other inflammatory mediators such as interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and cyclooxygenase-2 was also increased by the exposure to beta-glucan.	beta-Glucans	193-204	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	138-154
9395058-0	1997	Enhanced production of inducible nitric oxide synthase by beta-glucans in mice.	beta-Glucans	58-70	nitric oxide synthase 2, inducible	Mus musculus	23-54
9514898-7	1998	Further, NO production induced by anti-CR3 mAb was also inhibited by zymocel, beta-glucan with a high affinity to CR3.	beta-Glucans	78-89	integrin alpha M	Mus musculus	39-42
9514898-7	1998	Further, NO production induced by anti-CR3 mAb was also inhibited by zymocel, beta-glucan with a high affinity to CR3.	beta-Glucans	78-89	integrin alpha M	Mus musculus	114-117
9515908-1	1998	Deletion of GAS1/GGP1/CWH52 results in a lower beta-glucan content of the cell wall and swollen, more spherical cells (L. Popolo, M. Vai, E. Gatti, S. Porello, P. Bonfante, R. Balestrini, and L. Alberghina, J. Bacteriol.	beta-Glucans	47-58	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	12-16
9515908-1	1998	Deletion of GAS1/GGP1/CWH52 results in a lower beta-glucan content of the cell wall and swollen, more spherical cells (L. Popolo, M. Vai, E. Gatti, S. Porello, P. Bonfante, R. Balestrini, and L. Alberghina, J. Bacteriol.	beta-Glucans	47-58	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	17-21
9395058-3	1997	In this study, we analyzed production of inducible nitric oxide synthase (iNOS) induced by beta-glucans in vitro and in vivo.	beta-Glucans	91-103	nitric oxide synthase 2, inducible	Mus musculus	41-72
9395058-3	1997	In this study, we analyzed production of inducible nitric oxide synthase (iNOS) induced by beta-glucans in vitro and in vivo.	beta-Glucans	91-103	nitric oxide synthase 2, inducible	Mus musculus	74-78
9395058-6	1997	These findings suggest that a single helical conformer is essential for iNOS production, and that NO synthesis by beta-glucans is closely related to iNOS production.	beta-Glucans	114-126	nitric oxide synthase 2, inducible	Mus musculus	149-153
9138036-6	1997	Total IgG, IgG1, IgG2a, IgM and IgA immunoglobulins in the serum of beta-glucan-treated groups were overall higher than those in the non-treated group.	beta-Glucans	68-79	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	11-15
9331986-5	1997	Of beta-glucans tested, only SPG-OH and GRN produced high concentrations of IL-6 in the culture supernatants.	beta-Glucans	3-15	interleukin 6	Mus musculus	76-80
9209021-6	1997	Although we could not establish the null mutation of C. albicans GSC1, disruption of two of the three GSC1 alleles decreased both GSC1 mRNA and cell wall beta-glucan levels by about 50%.	beta-Glucans	154-165	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	102-106
9209021-6	1997	Although we could not establish the null mutation of C. albicans GSC1, disruption of two of the three GSC1 alleles decreased both GSC1 mRNA and cell wall beta-glucan levels by about 50%.	beta-Glucans	154-165	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	102-106
9138036-6	1997	Total IgG, IgG1, IgG2a, IgM and IgA immunoglobulins in the serum of beta-glucan-treated groups were overall higher than those in the non-treated group.	beta-Glucans	68-79	immunoglobulin heavy variable V1-9	Mus musculus	17-22
9138036-9	1997	IFN-gamma- and IL-4-secreting cells, in response to sporozoite antigen, were detected in the spleen and mesenteric lymph nodes of the beta-glucan-treated groups only.	beta-Glucans	134-145	interferon gamma	Mus musculus	0-9
9138036-9	1997	IFN-gamma- and IL-4-secreting cells, in response to sporozoite antigen, were detected in the spleen and mesenteric lymph nodes of the beta-glucan-treated groups only.	beta-Glucans	134-145	interleukin 4	Mus musculus	15-19
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	15-26	interferon gamma	Mus musculus	186-195
8751898-0	1996	Fungal beta-glucan interacts with vitronectin and stimulates tumor necrosis factor alpha release from macrophages.	beta-Glucans	7-18	vitronectin	Homo sapiens	34-45
8751898-0	1996	Fungal beta-glucan interacts with vitronectin and stimulates tumor necrosis factor alpha release from macrophages.	beta-Glucans	7-18	tumor necrosis factor	Homo sapiens	61-88
8751898-4	1996	Since vitronectin contains a carbohydrate-binding region, we postulated that vitronectin binds fungal beta-glucans and subsequently augments macrophage TNF-alpha release in response to this fungal component.	beta-Glucans	102-114	vitronectin	Homo sapiens	6-17
8751898-4	1996	Since vitronectin contains a carbohydrate-binding region, we postulated that vitronectin binds fungal beta-glucans and subsequently augments macrophage TNF-alpha release in response to this fungal component.	beta-Glucans	102-114	vitronectin	Homo sapiens	77-88
8751898-5	1996	To study this, we first determined the release of TNF-alpha from alveolar macrophages stimulated with fungal beta-glucan.	beta-Glucans	109-120	tumor necrosis factor	Homo sapiens	50-59
8751898-6	1996	Maximal TNF-alpha release occurred with moderate concentrations of beta-glucan (100 to 200 micrograms/ml), whereas higher concentrations of beta-glucan (&gt; or = 500 micrograms/ml) caused apparent suppression of the TNF-alpha activity released.	beta-Glucans	67-78	tumor necrosis factor	Homo sapiens	8-17
8751898-6	1996	Maximal TNF-alpha release occurred with moderate concentrations of beta-glucan (100 to 200 micrograms/ml), whereas higher concentrations of beta-glucan (&gt; or = 500 micrograms/ml) caused apparent suppression of the TNF-alpha activity released.	beta-Glucans	140-151	tumor necrosis factor	Homo sapiens	217-226
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	65-76	tumor necrosis factor	Homo sapiens	20-29
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	65-76	tumor necrosis factor	Homo sapiens	137-146
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	65-76	tumor necrosis factor	Homo sapiens	137-146
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	109-120	tumor necrosis factor	Homo sapiens	20-29
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	109-120	tumor necrosis factor	Homo sapiens	137-146
8751898-7	1996	This suppression of TNF-alpha activity by high concentrations of beta-glucan was mediated by the particulate beta-glucan binding soluble TNF-alpha, through the lectin-binding domain of the cytokine, rendering the TNF-alpha less available for measurement.	beta-Glucans	109-120	tumor necrosis factor	Homo sapiens	137-146
8751898-8	1996	Next, we assessed the interaction of vitronectin with beta-glucan.	beta-Glucans	54-65	vitronectin	Homo sapiens	37-48
8751898-9	1996	Binding of 125I-vitronectin to particulate fungal beta-glucan was dose dependent and specifically inhibitable by unlabeled vitronectin.	beta-Glucans	50-61	vitronectin	Homo sapiens	16-27
8751898-9	1996	Binding of 125I-vitronectin to particulate fungal beta-glucan was dose dependent and specifically inhibitable by unlabeled vitronectin.	beta-Glucans	50-61	vitronectin	Homo sapiens	123-134
8751898-10	1996	Furthermore, treatment of beta-glucan with vitronectin substantially augmented macrophage TNF-alpha release in response to this fungal component.	beta-Glucans	26-37	vitronectin	Homo sapiens	43-54
8751898-10	1996	Furthermore, treatment of beta-glucan with vitronectin substantially augmented macrophage TNF-alpha release in response to this fungal component.	beta-Glucans	26-37	tumor necrosis factor	Homo sapiens	90-99
8751898-11	1996	These findings demonstrate that fungal beta-glucan can directly modulate TNF-alpha release from macrophages.	beta-Glucans	39-50	tumor necrosis factor	Homo sapiens	73-82
8751898-12	1996	Further, these studies indicate that the host adhesive glycoprotein vitronectin specifically binds beta-glucan and augments macrophage cytokine release in response to this fungal element.	beta-Glucans	99-110	vitronectin	Homo sapiens	68-79
9492185-3	1997	The ability of oat beta-glucan (ObetaG) to stimulate IL-1 and TNF-alpha release from murine peritoneal macrophages and the murine macrophage cell line P338D1, was assessed.	beta-Glucans	19-30	interleukin 1 complex	Mus musculus	53-57
9492185-3	1997	The ability of oat beta-glucan (ObetaG) to stimulate IL-1 and TNF-alpha release from murine peritoneal macrophages and the murine macrophage cell line P338D1, was assessed.	beta-Glucans	19-30	tumor necrosis factor	Mus musculus	62-71
8922278-2	1996	The enzymes specifically hydrolyze beta-1,4 glycosyl bonds that are adjacent to beta-1,3 linkages in beta-glucan, a linear polysaccharide containing these bonds in an approximate ratio of 2.5:1.	beta-Glucans	101-112	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	35-43
8922278-2	1996	The enzymes specifically hydrolyze beta-1,4 glycosyl bonds that are adjacent to beta-1,3 linkages in beta-glucan, a linear polysaccharide containing these bonds in an approximate ratio of 2.5:1.	beta-Glucans	101-112	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	80-88
8922278-5	1996	In addition, the shape of the active site channel, the known binding mode of a cellobioside epoxyalkyl inhibitor and the energy profile of the beta-glucan substrate explain the specificity of the enzymes for beta-glucan and the requirement for a beta-1,3 glycosyl bond next to the scissile bond.	beta-Glucans	143-154	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	246-254
8922278-5	1996	In addition, the shape of the active site channel, the known binding mode of a cellobioside epoxyalkyl inhibitor and the energy profile of the beta-glucan substrate explain the specificity of the enzymes for beta-glucan and the requirement for a beta-1,3 glycosyl bond next to the scissile bond.	beta-Glucans	208-219	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	246-254
8699115-4	1996	We also found that preincubation of AMs with IFN-gamma enhanced the binding of fluorescein-labeled beta-glucan on the AM surface, and this increased binding was abrogated to the control level by the addition of three species of soluble unlabeled (1--&gt;3)-beta-D-glucans but not by soluble alpha-glucan.	beta-Glucans	99-110	interferon gamma	Mus musculus	45-54
8699115-5	1996	These data imply that the priming effect of IFN-gamma on the AM response to beta-glucan was dependent, at least in part, on the enhancement of beta-glucan specific binding sites on the AM surface.	beta-Glucans	76-87	interferon gamma	Mus musculus	44-53
8699115-5	1996	These data imply that the priming effect of IFN-gamma on the AM response to beta-glucan was dependent, at least in part, on the enhancement of beta-glucan specific binding sites on the AM surface.	beta-Glucans	143-154	interferon gamma	Mus musculus	44-53
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	15-26	interleukin 6	Mus musculus	296-300
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	15-26	tumor necrosis factor	Mus musculus	306-333
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	15-26	tumor necrosis factor	Mus musculus	335-344
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	interferon gamma	Mus musculus	46-62
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	interferon gamma	Mus musculus	64-73
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	interferon gamma	Mus musculus	186-195
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	interleukin 6	Mus musculus	296-300
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	tumor necrosis factor	Mus musculus	306-333
8699115-2	1996	Stimulation by beta-glucan (500 microg/mL) or interferon-gamma (IFN-gamma; 100 U/mL) alone had a slight effect on AM functions, but when AMs were incubated together with beta-glucan and IFN-gamma, the production and secretion of some immune mediators, such as nitric oxide, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were markedly augmented.	beta-Glucans	170-181	tumor necrosis factor	Mus musculus	335-344
8699115-3	1996	This combined effect of beta-glucan and IFN-gamma was based on a priming effect of IFN-gamma, because prestimulation with IFN-gamma followed by beta-glucan induced high nitric oxide production of AMs, but reversal of the sequence of treatments had only a slight effect.	beta-Glucans	24-35	interferon gamma	Mus musculus	83-92
8699115-3	1996	This combined effect of beta-glucan and IFN-gamma was based on a priming effect of IFN-gamma, because prestimulation with IFN-gamma followed by beta-glucan induced high nitric oxide production of AMs, but reversal of the sequence of treatments had only a slight effect.	beta-Glucans	24-35	interferon gamma	Mus musculus	83-92
8699115-3	1996	This combined effect of beta-glucan and IFN-gamma was based on a priming effect of IFN-gamma, because prestimulation with IFN-gamma followed by beta-glucan induced high nitric oxide production of AMs, but reversal of the sequence of treatments had only a slight effect.	beta-Glucans	144-155	interferon gamma	Mus musculus	40-49
8699115-3	1996	This combined effect of beta-glucan and IFN-gamma was based on a priming effect of IFN-gamma, because prestimulation with IFN-gamma followed by beta-glucan induced high nitric oxide production of AMs, but reversal of the sequence of treatments had only a slight effect.	beta-Glucans	144-155	interferon gamma	Mus musculus	83-92
8699115-3	1996	This combined effect of beta-glucan and IFN-gamma was based on a priming effect of IFN-gamma, because prestimulation with IFN-gamma followed by beta-glucan induced high nitric oxide production of AMs, but reversal of the sequence of treatments had only a slight effect.	beta-Glucans	144-155	interferon gamma	Mus musculus	83-92
7499871-3	1995	We provide evidence that both platelet-activating factor (PAF) and TGF-beta are involved in beta-glucan induction of PS recognition.	beta-Glucans	92-103	patchy fur	Mus musculus	30-56
8860968-15	1996	These facts strongly suggested that beta-glucan has capacity to enhance NO synthesis of PM in vivo through IFN gamma mediated mechanism.	beta-Glucans	36-47	interferon gamma	Mus musculus	107-116
8820904-8	1996	The results suggested that genistein-sensitive tyrosine kinase and bromophenacyl bromide-sensitive phospholipase A2 participated in the particulate beta-glucans-triggered H2O2 production, although the phagocytosis of particulate beta-glucans was not inhibited by either reagents.	beta-Glucans	148-160	phospholipase A2, group IB, pancreas	Mus musculus	99-115
8550469-0	1996	HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern in the yeast Saccharomyces cerevisiae.	beta-Glucans	66-77	Hkr1p	Saccharomyces cerevisiae S288C	0-4
8550469-9	1996	These results demonstrate that HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern and suggest that bud site assembly is somehow related to beta-glucan synthesis in S. cerevisiae.	beta-Glucans	97-108	Hkr1p	Saccharomyces cerevisiae S288C	31-35
8550469-9	1996	These results demonstrate that HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern and suggest that bud site assembly is somehow related to beta-glucan synthesis in S. cerevisiae.	beta-Glucans	196-207	Hkr1p	Saccharomyces cerevisiae S288C	31-35
7499871-3	1995	We provide evidence that both platelet-activating factor (PAF) and TGF-beta are involved in beta-glucan induction of PS recognition.	beta-Glucans	92-103	patchy fur	Mus musculus	58-61
7499871-3	1995	We provide evidence that both platelet-activating factor (PAF) and TGF-beta are involved in beta-glucan induction of PS recognition.	beta-Glucans	92-103	transforming growth factor, beta 1	Mus musculus	67-75
7499871-4	1995	This is based on the observations that the PAF receptor antagonist WEB 2086 and Ab against TGF-beta each could partially inhibit beta-glucan-induced PS recognition when used alone and could completely inhibit induction when used in combination.	beta-Glucans	129-140	patchy fur	Mus musculus	43-46
7499871-4	1995	This is based on the observations that the PAF receptor antagonist WEB 2086 and Ab against TGF-beta each could partially inhibit beta-glucan-induced PS recognition when used alone and could completely inhibit induction when used in combination.	beta-Glucans	129-140	transforming growth factor, beta 1	Mus musculus	91-99
8586593-4	1995	Pigs fed beta-glucan from d 7 to 14 after weaning had lower ADFI (P &lt; .01) and, although not significant, ADG was lower for pigs fed beta-glucan than for pigs fed control diets.	beta-Glucans	9-20	ADG	Sus scrofa	109-112
7500943-1	1995	The Saccharomyces cerevisiae KRE1 gene encodes a secretory protein required for the production of the cell wall polymer (1--&gt;6)-beta-glucan.	beta-Glucans	131-142	Kre1p	Saccharomyces cerevisiae S288C	29-33
7500943-7	1995	Such a localization of Kre1p seems to parallel the CAL1/CSD2-dependent cell wall deposition of chitin found in S. cerevisiae, and is consistent with evidence from Schizophyllum commune that (1--&gt;6)-beta-glucan accumulates during maturation of the subapical region of the wall distal to the hyphal tip.	beta-Glucans	201-212	Kre1p	Saccharomyces cerevisiae S288C	23-28
8586593-4	1995	Pigs fed beta-glucan from d 7 to 14 after weaning had lower ADFI (P &lt; .01) and, although not significant, ADG was lower for pigs fed beta-glucan than for pigs fed control diets.	beta-Glucans	136-147	ADG	Sus scrofa	109-112
8586593-14	1995	However, pigs fed diets containing .025% beta-glucan had increased (P &lt; .05) ADG and ADFI and were heavier (P &lt; .05) on d 28 after weaning than pigs fed the control diet.	beta-Glucans	41-52	ADG	Sus scrofa	80-83
8586593-16	1995	Pigs fed beta-glucan had decreased (P &lt; .10) plasma haptoglobin on d 14, 21, and 28 after weaning.	beta-Glucans	9-20	haptoglobin	Sus scrofa	55-66
7565587-0	1995	Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription.	beta-Glucans	24-35	type 2C protein phosphatase PTC1	Saccharomyces cerevisiae S288C	46-50
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	beta-Glucans	90-101	granulin	Mus musculus	0-3
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	beta-Glucans	90-101	tumor necrosis factor	Mus musculus	14-23
8593430-12	1995	In conclusion, TNF alpha release by macrophages is induced only by beta-glucans with high molecular weights and lower branching ratios, and the mechanism for the recognition of beta-glucans is multiple and assumed to be divided into several parts involving various cellular functions.	beta-Glucans	67-79	tumor necrosis factor	Mus musculus	15-24
8593430-12	1995	In conclusion, TNF alpha release by macrophages is induced only by beta-glucans with high molecular weights and lower branching ratios, and the mechanism for the recognition of beta-glucans is multiple and assumed to be divided into several parts involving various cellular functions.	beta-Glucans	177-189	tumor necrosis factor	Mus musculus	15-24
7588797-14	1995	However, the 10-fold reduction of UGPase activity induced a multi-budding pattern, a higher resistance to zymolyase, a slight increase in the calcofluor sensitivity and a decrease in the cell-wall beta-glucan content.	beta-Glucans	197-208	UTP--glucose-1-phosphate uridylyltransferase	Solanum tuberosum	34-40
7565587-0	1995	Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription.	beta-Glucans	24-35	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	70-74
7565587-0	1995	Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription.	beta-Glucans	24-35	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	123-127
7565587-1	1995	Analysis of genes involved in yeast cell wall beta-glucan assembly has led to the isolation of EXG1, PBS2 and PTC1.	beta-Glucans	46-57	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	95-99
7565587-1	1995	Analysis of genes involved in yeast cell wall beta-glucan assembly has led to the isolation of EXG1, PBS2 and PTC1.	beta-Glucans	46-57	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	101-105
7565587-1	1995	Analysis of genes involved in yeast cell wall beta-glucan assembly has led to the isolation of EXG1, PBS2 and PTC1.	beta-Glucans	46-57	type 2C protein phosphatase PTC1	Saccharomyces cerevisiae S288C	110-114
7565587-6	1995	Disruption of PTC1/CWH47 and overexpression of PBS2 gave rise to similar beta-glucan related phenotypes, with higher levels of EXG1 transcription, increased exo-beta-glucanase activity, reduced beta 1,6-glucan levels, and resistance to killer toxin.	beta-Glucans	73-84	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	47-51
7642509-3	1995	revealed induction of transcription of the celA gene when barley beta-glucan was used as carbon source, while no celA mRNA was detected after growth on cellobiose.	beta-Glucans	65-76	kil protein	Escherichia coli	43-47
7828729-4	1995	The transcription of CWH53 was cell cycle-dependent and, similar to GAS1/CWH52, increased in late G1, indicating that the formation of beta-glucan is cell cycle-regulated.	beta-Glucans	135-146	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	21-26
7828729-4	1995	The transcription of CWH53 was cell cycle-dependent and, similar to GAS1/CWH52, increased in late G1, indicating that the formation of beta-glucan is cell cycle-regulated.	beta-Glucans	135-146	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	68-72
7828729-4	1995	The transcription of CWH53 was cell cycle-dependent and, similar to GAS1/CWH52, increased in late G1, indicating that the formation of beta-glucan is cell cycle-regulated.	beta-Glucans	135-146	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	73-78
8031863-0	1994	A role for reactive oxygen species in zymosan and beta-glucan induced protein tyrosine phosphorylation and phospholipase A2 activation in murine macrophages.	beta-Glucans	50-61	phospholipase A2, group IB, pancreas	Mus musculus	107-123
8031863-2	1994	Here we show that the interaction of beta-glucan particles (glucanp) or zymosan with complement receptor type 3 (CR3) leads, when associated with vanadate, to a cascade of reactions culminating in PLA2 activation.	beta-Glucans	37-48	integrin alpha M	Mus musculus	85-111
8031863-2	1994	Here we show that the interaction of beta-glucan particles (glucanp) or zymosan with complement receptor type 3 (CR3) leads, when associated with vanadate, to a cascade of reactions culminating in PLA2 activation.	beta-Glucans	37-48	integrin alpha M	Mus musculus	113-116
8031863-2	1994	Here we show that the interaction of beta-glucan particles (glucanp) or zymosan with complement receptor type 3 (CR3) leads, when associated with vanadate, to a cascade of reactions culminating in PLA2 activation.	beta-Glucans	37-48	phospholipase A2, group IB, pancreas	Mus musculus	197-201
7929594-1	1994	A characterization of the S. cerevisiae KRE6 and SKN1 gene products extends previous genetic studies on their role in (1--&gt;6)-beta-glucan biosynthesis (Roemer, T., and H. Bussey.	beta-Glucans	129-140	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	40-44
7929594-1	1994	A characterization of the S. cerevisiae KRE6 and SKN1 gene products extends previous genetic studies on their role in (1--&gt;6)-beta-glucan biosynthesis (Roemer, T., and H. Bussey.	beta-Glucans	129-140	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	49-53
7929594-3	1994	Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro.	beta-Glucans	6-17	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	29-33
7929594-11	1994	SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis.	beta-Glucans	99-110	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	0-4
7929594-11	1994	SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis.	beta-Glucans	99-110	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	9-13
7929594-16	1994	KRE6 and SKN1 are predicted to encode homologous proteins that participate in assembly of the cell wall polymer (1--&gt;6)-beta-glucan.	beta-Glucans	123-134	beta-glucan synthesis-associated protein KRE6	Saccharomyces cerevisiae S288C	0-4
7929594-16	1994	KRE6 and SKN1 are predicted to encode homologous proteins that participate in assembly of the cell wall polymer (1--&gt;6)-beta-glucan.	beta-Glucans	123-134	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	9-13
8113191-10	1994	Furthermore, overexpression of HKR1 increased the beta-glucan content in the cell wall without affecting in vitro beta-glucan synthase activity, suggesting that HKR1 regulates beta-glucan synthesis in vivo.	beta-Glucans	50-61	Hkr1p	Saccharomyces cerevisiae S288C	31-35