PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset
2594778-1 1989 Urate oxidase, or uricase (EC 1.7.3.3), is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals. Uric Acid 96-105 urate oxidase Sus scrofa 0-13
2594778-1 1989 Urate oxidase, or uricase (EC 1.7.3.3), is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals. Uric Acid 96-105 urate oxidase (pseudogene) Homo sapiens 18-25
2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 36-52 interleukin 6 Homo sapiens 171-175
2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 54-57 interleukin 6 Homo sapiens 171-175
2527676-2 1989 In the diabetic patients, uric acid clearance/creatinine clearance (Clurate/Clcr) was higher and the serum level of uric acid was lower than in the normal subjects (Clurate/Clcr: 10.9 +/- 5.8 vs 8.1 +/- 2.6%, p less than 0.001; serum uric acid: 3.4 +/- 86 vs 357 +/- 89 mumol l-1, p less than 0.001). Uric Acid 26-35 chymotrypsin C Homo sapiens 76-80
2585836-6 1989 On the other hand, the patients whose CUA levels lower than 6.0 ml/min in the distribution of CUA that suggested a decrease of uric acid excretion registered 47.4% in IgAN and 63.0% in MGN, respectively, which equally appeared to be a type of lowered excretion in a majority of patients whose hyperuricemia was recognized in IgAN and MGN. Uric Acid 127-136 IGAN1 Homo sapiens 167-171
2585836-6 1989 On the other hand, the patients whose CUA levels lower than 6.0 ml/min in the distribution of CUA that suggested a decrease of uric acid excretion registered 47.4% in IgAN and 63.0% in MGN, respectively, which equally appeared to be a type of lowered excretion in a majority of patients whose hyperuricemia was recognized in IgAN and MGN. Uric Acid 127-136 IGAN1 Homo sapiens 325-329
2567208-3 1989 Allopurinol was also given to inhibit xanthine oxidase activity to decrease uric acid excretion and to elevate the serum concentration of hypoxanthine, which should competitively inhibit the activity of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8), the salvage enzyme of guanylate synthesis. Uric Acid 76-85 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 203-249
2482345-4 1989 This study showed a significant correlation between the levels of serum IL-2R and disease activities, i.e., levels of urinary protein, blood urea nitrogen (BUN) and uric acid, in patients with IgA nephropathy. Uric Acid 165-174 interleukin 2 receptor subunit alpha Homo sapiens 72-77
2795662-5 1989 Urate is the end product of the reaction catalysed by xanthine oxidoreductase. Uric Acid 0-5 xanthine dehydrogenase Homo sapiens 54-77
2795662-8 1989 We conclude that xanthine oxidoreductase is probably present in the heart of patients, suffering from ischemic heart disease, and responsible for the increase in urate production during transient myocardial ischemia. Uric Acid 162-167 xanthine dehydrogenase Homo sapiens 17-40
2810861-4 1989 By t-tests of all before-and-after data, it was shown that mean values of body weight, systolic blood pressure, high-density-lipoprotein cholesterol, triglyceride, phospholipid and gamma-GTP were improved, but fasting blood sugar, uric acid and GOT were not improved. Uric Acid 231-240 inactive glutathione hydrolase 2 Homo sapiens 181-190
2539367-7 1989 Reduction of these enzymes by xanthine was limited at a rate comparable to that for the release of urate from native XDH. Uric Acid 99-104 xanthine dehydrogenase Gallus gallus 117-120
2915120-4 1989 The transplantable murine fibrosarcoma, Meth A, a TNF-sensitive line in vivo, was less sensitive to rhTNF and host toxicity was reduced when the hosts were pretreated with uric acid, a major reactive oxygen scavenger in humans and certain other primates. Uric Acid 172-181 tumor necrosis factor Rattus norvegicus 50-53
2692881-2 1989 In comparison with normal pregnant women and normal non-pregnant women, women with PIH showed an increase in heart rate, suggesting an increased peripheral sympathetic tone, and an initial derangement in renal function as shown by the increase in serum uric acid and reduction in sodium excretion and total and fractional calcium excretion at any given level of sodium excretion. Uric Acid 253-262 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 83-86
2698352-0 1989 The insulin response to oral glucose, concentrations of total cholesterol, triglycerides and uric acid in women with idiopathic hirsutism. Uric Acid 93-102 insulin Homo sapiens 4-11
2744787-7 1989 The MAb has been used to demonstrate that a leukotactic protein is released from polymorphonuclear leukocytes (PMN) and promyelocytic HL-60 cells in response to a phagocytic or degranulating stimuli such as monosodium urate crystals or N-formyl-Met-Leu-Phe (FMLP), respectively. Uric Acid 207-223 formyl peptide receptor 1 Homo sapiens 236-256
2744787-7 1989 The MAb has been used to demonstrate that a leukotactic protein is released from polymorphonuclear leukocytes (PMN) and promyelocytic HL-60 cells in response to a phagocytic or degranulating stimuli such as monosodium urate crystals or N-formyl-Met-Leu-Phe (FMLP), respectively. Uric Acid 207-223 formyl peptide receptor 1 Homo sapiens 258-262
2803824-3 1989 Allopurinol, a xanthine oxidoreductase inhibitor, has been found to markedly suppress the uric acid production in the same experimental settings. Uric Acid 90-99 xanthine dehydrogenase Rattus norvegicus 15-38
2538353-4 1989 We propose that radicals formed by attack of .OH on uric acid are themselves able to inactivate alpha 1-antiproteinase, but that these uric acid radicals can be "repaired" by ascorbic acid. Uric Acid 52-61 serpin family A member 1 Homo sapiens 96-118
2800538-6 1989 The suitable medium for uricase formation was consisted of sucrose 5%, corn steep liquor 3%, uric acid 0.1%, proteose-peptone 0.1%, biotin 0.05%, KCl 0.1%, NaCl 0.1% at pH 6.2. Uric Acid 93-102 uricase Zea mays 24-31
2624206-4 1989 On the other hand, all of these drugs increased the (Tua/Pua)/(Tin/Pin) value in the tubules in PZO-treated rats, which suggested that they also inhibited the reabsorptive flux of urate. Uric Acid 180-185 dynein light chain LC8-type 1 Rattus norvegicus 67-70
2670218-3 1989 Angiotensin-converting enzyme (ACE) inhibitors are lipid neutral and associated with few metabolic side effects, and may be considered over agents that cause adverse effects on such parameters as serum cholesterol, glucose, potassium, and uric acid levels. Uric Acid 239-248 angiotensin I converting enzyme Homo sapiens 0-29
2670218-3 1989 Angiotensin-converting enzyme (ACE) inhibitors are lipid neutral and associated with few metabolic side effects, and may be considered over agents that cause adverse effects on such parameters as serum cholesterol, glucose, potassium, and uric acid levels. Uric Acid 239-248 angiotensin I converting enzyme Homo sapiens 31-34
3192041-1 1988 Uricase is a peroxisomal liver enzyme that catalyzes the oxidation of uric acid to allantoin during purine catabolism. Uric Acid 70-79 urate oxidase (pseudogene) Homo sapiens 0-7
2614025-8 1989 There was a relationship between plasma fibronectin (greater than 0.4 g/l) and uric acid rise (greater than 50 mg/l) (chi 2 test: p less than 0.01). Uric Acid 79-88 fibronectin 1 Homo sapiens 40-51
3199797-1 1988 The ability of specific low molecular weight sulfhydryl compounds to inhibit the myoglobin-H2O2 peroxidation of uric acid and arachidonic acid was investigated. Uric Acid 112-121 myoglobin Homo sapiens 81-90
3194410-1 1988 Urate oxidase (UOxase; urate:oxygen oxidoreductase, EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but is absent in humans and certain primates. Uric Acid 98-107 urate oxidase Rattus norvegicus 0-13
3186090-2 1988 The purpose of this study was to evaluate the relationship between plasma antithrombin III activity and both clotting parameters (platelet count and fibrinopeptide A) and renal parameters (serum creatinine and uric acid concentration). Uric Acid 210-219 serpin family C member 1 Homo sapiens 74-90
2844196-8 1988 AHSG also bound in vitro to the related BCP crystal, octacalcium phosphate, but only minimally to calcium pyrophosphate dihydrate crystals and monosodium urate crystals. Uric Acid 143-159 alpha 2-HS glycoprotein Homo sapiens 0-4
2907144-1 1988 Gout: the possible role of albumin in sodium urate crystallization. Uric Acid 38-50 albumin Homo sapiens 27-34
2907144-2 1988 The interactions between sodium urate monohydrate (MSU) crystals and human serum albumin (HSA) were investigated in vitro in relation to the disease of gout. Uric Acid 25-49 albumin Homo sapiens 75-88
3166459-0 1988 Rapid reaction studies on the reduction and oxidation of chicken liver xanthine dehydrogenase by the xanthine/urate and NAD/NADH couples. Uric Acid 110-115 xanthine dehydrogenase Gallus gallus 71-93
3166459-5 1988 Oxidation of fully (6-electron) reduced xanthine dehydrogenase by either urate or NAD is monophasic and dependent on the oxidant concentration. Uric Acid 73-78 xanthine dehydrogenase Gallus gallus 40-62
2843048-1 1988 PURPOSE: Superactivity of 5-phosphoribosyl 1-pyrophosphate (PP-Rib-P) synthetase, inherited as an X chromosome-linked trait, has been reported in nearly 20 families in which overproduction of uric acid is invariably present in hemizygous affected males. Uric Acid 192-201 phosphoribosyl pyrophosphate synthetase 2 Homo sapiens 60-80
2843048-4 1988 We herein document the association of PP-Rib-P synthetase superactivity, gout with excessive uric acid synthesis, and sensorineural deafness in an additional family. Uric Acid 93-102 phosphoribosyl pyrophosphate synthetase 2 Homo sapiens 38-57
3409526-1 1988 We describe a simple, kinetic method for the determination of serum guanase activity that involves enzymatic coupling to xanthine oxidase and measurement of the rate of uric acid formation by spectrophotometric monitoring of the absorption at 300 nm. Uric Acid 169-178 guanine deaminase Homo sapiens 68-75
3263237-4 1988 The median nadir urinary uric acid to urinary creatinine ratio during IL-2 therapy was 0.2. Uric Acid 25-34 interleukin 2 Homo sapiens 70-74
3266876-0 1988 Interleukin-1 production from monocyte induced by urate crystals. Uric Acid 50-55 interleukin 1 alpha Homo sapiens 0-13
3177093-1 1988 We have investigated the effect of tunicamycin-C2, which specifically inhibits glycosylation of proteins but not their synthesis, in the induction of crystal-induced chemotactic factor (CCF) in human neutrophils by monosodium urate crystals. Uric Acid 215-231 paired like homeodomain 1 Homo sapiens 150-184
3177093-1 1988 We have investigated the effect of tunicamycin-C2, which specifically inhibits glycosylation of proteins but not their synthesis, in the induction of crystal-induced chemotactic factor (CCF) in human neutrophils by monosodium urate crystals. Uric Acid 215-231 paired like homeodomain 1 Homo sapiens 186-189
3411123-6 1988 Angiotensin II evoked a dose-dependent pressor response, a graded increase in PAC and a reduction in sodium and urate excretion in both pregnant and non-pregnant women. Uric Acid 112-117 angiotensinogen Homo sapiens 0-14
3169035-3 1988 These hepatocytes contain two liver-specific proteins: carbamyl phosphate synthetase I, a mitochondrial matrix protein that participates in the conversion of ammonia to carbamyl phosphate; and urate oxidase, an enzyme that catalyzes the oxidation of uric acid to allantoin. Uric Acid 250-259 urate oxidase Rattus norvegicus 193-206
3378319-5 1988 Concentrations of the classical markers urea, uric acid, creatinine, and phosphate were closely related to PC2 in these patients. Uric Acid 46-55 chromobox 4 Homo sapiens 107-110
3411123-7 1988 The administration of Ang II had a proportionately greater effect on sodium and urate excretion in non-pregnant than in pregnant women; the pressor response to Ang II was also decreased in the pregnant women. Uric Acid 80-85 angiotensinogen Homo sapiens 22-28
3422556-8 1988 It was concluded that xanthine dehydrogenase requires a minimum mechanism of degree 1:1 for xanthine, 2:2 for NAD+, 1:1 for uric acid and 1:2 for NADH in the xanthine/NAD+ oxidoreductase reaction. Uric Acid 124-133 xanthine dehydrogenase Gallus gallus 22-44
3132023-2 1988 We reported a modified procedure for histochemical demonstration of guanase in human tissues involving hydrolytic deamination of the substrate guanine to xanthine via guanase, and then oxidation of xanthine to uric acid, with concomitant reduction of nitrotetrazolium blue (NBT). Uric Acid 210-219 guanine deaminase Homo sapiens 68-75
2970708-5 1988 The urokinase/plasmin system was inhibited up to 94.4% with 0.5 mM urate. Uric Acid 67-72 plasminogen Homo sapiens 14-21
3661720-2 1987 Urate uptake was only evident in proteoliposomes that contained active uricase. Uric Acid 0-5 urate oxidase Sus scrofa 71-78
3325394-4 1987 The antihypertensive effect of ACE inhibitors is characterized by some particularly favorable features: ACE inhibitors attenuate the fall in serum potassium and the rise in plasma uric acid induced by diuretics, they do not cause any salt retention nor orthostatic hypotension, they do not raise pulse rate when they reduce blood pressure, and they certainly do not reduce the perfusion rate of the brain, the heart or the kidneys. Uric Acid 180-189 angiotensin I converting enzyme Homo sapiens 31-34
3325394-4 1987 The antihypertensive effect of ACE inhibitors is characterized by some particularly favorable features: ACE inhibitors attenuate the fall in serum potassium and the rise in plasma uric acid induced by diuretics, they do not cause any salt retention nor orthostatic hypotension, they do not raise pulse rate when they reduce blood pressure, and they certainly do not reduce the perfusion rate of the brain, the heart or the kidneys. Uric Acid 180-189 angiotensin I converting enzyme Homo sapiens 104-107
3428293-0 1987 Impaired kinetic properties of hypoxanthine-guanine phosphoribosyl transferase as a cause of uric acid nephropathy in early infancy. Uric Acid 93-102 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 31-78
3428293-5 1987 It seems therefore, that in cases of uric acid over-production, screening tests of HGPRT activity may be insufficient and additional kinetic properties of the enzyme should be tested. Uric Acid 37-46 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 83-88
2960987-2 1987 Previous research suggests that in caudate peak 1 (P1) monitors ascorbic acid and peak 2 (P2) monitors uric acid. Uric Acid 103-112 PEAK1 related, kinase-activating pseudokinase 1 Homo sapiens 82-88
3661720-6 1987 Finally, the kinetics of urate uptake and oxidation were virtually identical, implying that the transporter is uricase. Uric Acid 25-30 urate oxidase Sus scrofa 111-118
3661720-7 1987 Thus, these studies provide evidence that uricase can function as a transport protein for urate when inserted in a lipid bilayer: transport via uricase is neither cation dependent (not a cotransporter) nor dependent on an exchangeable anion (not a urate/anion exchanger). Uric Acid 90-95 urate oxidase Sus scrofa 42-49
3661720-7 1987 Thus, these studies provide evidence that uricase can function as a transport protein for urate when inserted in a lipid bilayer: transport via uricase is neither cation dependent (not a cotransporter) nor dependent on an exchangeable anion (not a urate/anion exchanger). Uric Acid 90-95 urate oxidase Sus scrofa 144-151
3028263-0 1987 Generation of allantoin from the oxidation of urate by cytochrome c and its possible role in Reye"s syndrome. Uric Acid 46-51 cytochrome c, somatic Homo sapiens 55-67
3426527-1 1987 We isolated and purified xanthine oxidase by Sephadex gel filtration and assayed the activity of the enzyme by urate production which we measured by HPLC and UV absorption at 290 nm. Uric Acid 111-116 xanthine dehydrogenase Sus scrofa 25-41
3426528-1 1987 Xanthine oxidase activities of pig myocardium and blood during and following myocardial ischemia were measured using HPLC, and electrochemical detection of hypoxanthine, xanthine and uric acid. Uric Acid 183-192 xanthine dehydrogenase Sus scrofa 0-16
3426528-6 1987 In contrast, significant amounts of xanthine and/or urate were produced, following addition of xanthine oxidase to the reaction mixtures. Uric Acid 52-57 xanthine dehydrogenase Sus scrofa 95-111
3114436-6 1987 Within the lymphoma group, the soluble IL-2R level was found to be the most significant prognostic indicator of disease-free interval and survival when compared with other previously recognized factors such as histology, stage, bone marrow involvement at presentation, lactic dehydrogenase (LDH), uric acid (UA), and age. Uric Acid 297-306 interleukin 2 receptor subunit alpha Homo sapiens 39-44
3114436-6 1987 Within the lymphoma group, the soluble IL-2R level was found to be the most significant prognostic indicator of disease-free interval and survival when compared with other previously recognized factors such as histology, stage, bone marrow involvement at presentation, lactic dehydrogenase (LDH), uric acid (UA), and age. Uric Acid 308-310 interleukin 2 receptor subunit alpha Homo sapiens 39-44
2959232-13 1987 The simultaneous changes in FeAU and in ACE activity indicate that the effect on uric acid excretion is presumably due to the fall in angiotensin concentration. Uric Acid 81-90 angiotensin I converting enzyme Homo sapiens 40-43
3033070-7 1987 As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release. Uric Acid 324-329 interleukin 1 alpha Homo sapiens 84-88
3033070-7 1987 As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release. Uric Acid 324-329 interleukin 1 alpha Homo sapiens 222-226
3033070-7 1987 As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release. Uric Acid 324-329 interleukin 1 alpha Homo sapiens 222-226
3565579-5 1987 alpha-Lactalbumin and beta-lactoglobulin, derived from milk, also inhibited urate and PAH transport, but to a lesser extent than albumin and gamma-globulin. Uric Acid 76-81 alpha-lactalbumin Oryctolagus cuniculus 0-17
3548194-7 1987 As the insulin infusion progressed, the urea nitrogen, uric acid and bicarbonate levels fell as well. Uric Acid 55-64 insulin Homo sapiens 7-14
3322912-1 1987 In a representative sample of the adult Jewish population in Israel (n = 1016) excluding known diabetic patients and individuals on antihypertensive medications, serum uric acid showed a positive association with plasma insulin response (sum of 1- and 2-hour post glucose load levels) in both males (r = 0.316, p less than 0.001) and females (r = 0.236, p less than 0.001). Uric Acid 168-177 insulin Homo sapiens 220-227
3322912-3 1987 The net portion of the variance of serum uric acid attributable to insulin response was 12% in males and 8% in females, the total variance accountable by all these variables being 17% and 19% respectively. Uric Acid 41-50 insulin Homo sapiens 67-74
3555347-3 1987 Urate (1 mM) which stimulates H2O2 production in living systems, increased ethanol oxidation fourfold in control but not in cells from aminotriazole-treated animals, documenting effective inhibition of catalase-mediated ethanol peroxidation by aminotriazole. Uric Acid 0-5 catalase Homo sapiens 202-210
3469021-1 1987 Both xanthine dehydrogenase (XD) and xanthine oxidase (XO) catalyze the conversion of hypoxanthine to xanthine, and xanthine to uric acid. Uric Acid 128-137 xanthine dehydrogenase Mus musculus 5-27
3469021-1 1987 Both xanthine dehydrogenase (XD) and xanthine oxidase (XO) catalyze the conversion of hypoxanthine to xanthine, and xanthine to uric acid. Uric Acid 128-137 xanthine dehydrogenase Mus musculus 37-53
3100598-5 1987 Plasma t-PA inhibitor levels also correlated significantly with serum triglyceride levels (r - 0.60, p less than 0.001), but not with coronary risk factors such as serum cholesterol, diabetes, hypertension, serum uric acid levels or body weight. Uric Acid 213-222 plasminogen activator, tissue type Homo sapiens 7-11
3038429-7 1987 The "metabolic-profile" with ACE inhibitors appears favourable, since they can increase uric acid excretion and lower plasma urate levels, carbohydrate tolerance is unaltered or improved, and lipid levels are unchanged. Uric Acid 88-97 angiotensin I converting enzyme Homo sapiens 29-32
3038429-7 1987 The "metabolic-profile" with ACE inhibitors appears favourable, since they can increase uric acid excretion and lower plasma urate levels, carbohydrate tolerance is unaltered or improved, and lipid levels are unchanged. Uric Acid 125-130 angiotensin I converting enzyme Homo sapiens 29-32
3311606-6 1987 Insulin decreased the incorporation of the infused glutamine amide-15N into urinary uric acid as well as the excretion of other N-derived urinary uric acid (P less than 0.05), which resulted in a significant decrease in total urinary uric acid (P less than 0.05). Uric Acid 84-93 insulin Gallus gallus 0-7
3311606-6 1987 Insulin decreased the incorporation of the infused glutamine amide-15N into urinary uric acid as well as the excretion of other N-derived urinary uric acid (P less than 0.05), which resulted in a significant decrease in total urinary uric acid (P less than 0.05). Uric Acid 146-155 insulin Gallus gallus 0-7
3311606-6 1987 Insulin decreased the incorporation of the infused glutamine amide-15N into urinary uric acid as well as the excretion of other N-derived urinary uric acid (P less than 0.05), which resulted in a significant decrease in total urinary uric acid (P less than 0.05). Uric Acid 146-155 insulin Gallus gallus 0-7
3028263-3 1987 Urate is a strong reducing agent which can reduce cytochrome c nonenzymatically, with the concomitant production of CO2 and H+. Uric Acid 0-5 cytochrome c, somatic Homo sapiens 50-62
3028263-5 1987 The initial reaction rate depended on the concentrations of both urate and cytochrome c, with reaction kinetics that were first order with respect to urate and second order with respect to cytochrome c. Uric Acid 65-70 cytochrome c, somatic Homo sapiens 189-201
3028263-5 1987 The initial reaction rate depended on the concentrations of both urate and cytochrome c, with reaction kinetics that were first order with respect to urate and second order with respect to cytochrome c. Uric Acid 150-155 cytochrome c, somatic Homo sapiens 75-87
3583299-3 1987 SAHH activity has been assayed in 50 healthy individuals and the mean activity was 0.043 +/- 0.017 mumol uric acid/min/g Hb at 37 degrees C. Five heterozygotes for adenosine deaminase deficiency and three heterozygotes for purine nucleoside phosphorylase deficiency showed SAHH within the range of the normal distribution. Uric Acid 105-114 adenosylhomocysteinase Homo sapiens 0-4
3028263-9 1987 We propose that allantoin can be generated from the oxidation of urate by cytochrome c+3, and that this is a potential source of allantoin in human tissues. Uric Acid 65-70 cytochrome c, somatic Homo sapiens 74-86
3096995-5 1986 However, incorporation of apoB-100 into liposomes via cholate dialysis rendered them nearly as inhibitory for urate-induced neutrophil CL as LDL on a protein weight basis. Uric Acid 110-115 apolipoprotein B Homo sapiens 26-34
3784914-5 1986 The maximum uricosuric response promoted by probenecid at high serum urate levels was (mean +/- SD) 3,707 +/- 443 micrograms/min/1.73 m2 in controls and 2,215 +/- 738 micrograms/min/1.73 m2 in patients with gout (P less than 0.01). Uric Acid 69-74 CD59 molecule (CD59 blood group) Homo sapiens 125-130
3096995-7 1986 Modifications of the lysine residues of apoB (e.g. acetylation) reduced both the capacity of LDL to inhibit urate crystal-induced CL and to bind to urate crystals. Uric Acid 108-113 apolipoprotein B Homo sapiens 40-44
3096995-7 1986 Modifications of the lysine residues of apoB (e.g. acetylation) reduced both the capacity of LDL to inhibit urate crystal-induced CL and to bind to urate crystals. Uric Acid 148-153 apolipoprotein B Homo sapiens 40-44
3028048-8 1986 From these results the principal physiological function of the cytosol 5"-nucleotidase is assumed to be dephosphorylation of IMP as the first step in the pathway of uric acid formation from IMP, which is important in the elimination of nitrogen of amino acids and proteins in a uricotelic animal. Uric Acid 165-174 5'-nucleotidase ecto Gallus gallus 71-86
3568913-0 1986 [Observations on the effect of PZA, EB and RFP on uric acid metabolism]. Uric Acid 50-59 tripartite motif containing 27 Homo sapiens 43-46
3963371-0 1986 Immobilization of uricase on protamine bound to glass beads and its application to determination of uric acid. Uric Acid 100-109 urate oxidase (pseudogene) Homo sapiens 18-25
3963371-5 1986 Automated analysis of uric acid was facilitated using the immobilized uricase. Uric Acid 22-31 urate oxidase (pseudogene) Homo sapiens 70-77
2869452-5 1986 The effect of adenosine deaminase on the urate signal provides preliminary evidence that changes in this signal may reflect variations in the release of adenosine. Uric Acid 41-46 adenosine deaminase Rattus norvegicus 14-33
3025938-1 1986 Monosodium urate (MSU)-induced synovitis in the dog"s stifle (knee joint) is similar to an acute gouty attack in man in which a loss of function of the joint correlates with massive influx of neutrophils and the release of an assortment of inflammatory mediators (e.g. histamine, bradykinin, lysosomal enzymes, complement and eicosanoids) into the synovial space. Uric Acid 0-16 kininogen 1 Homo sapiens 280-290
3025938-1 1986 Monosodium urate (MSU)-induced synovitis in the dog"s stifle (knee joint) is similar to an acute gouty attack in man in which a loss of function of the joint correlates with massive influx of neutrophils and the release of an assortment of inflammatory mediators (e.g. histamine, bradykinin, lysosomal enzymes, complement and eicosanoids) into the synovial space. Uric Acid 18-21 kininogen 1 Homo sapiens 280-290
2423135-1 1986 Phosphoribosyl pyrophosphate (PPRibP) synthetase activity was studied in cultured fibroblasts and lymphoblasts from a male child (patient 2-A) in whom inherited purine nucleotide and uric acid overproduction are accompanied by neurological deficits. Uric Acid 183-192 phosphoribosyl pyrophosphate synthetase 2 Homo sapiens 0-48
3524096-0 1986 Serum uric acid correlates with beta 2-microglobulin in pre-eclampsia. Uric Acid 6-15 beta-2-microglobulin Homo sapiens 32-52
3524096-3 1986 A positive linear correlation between serum uric acid and beta 2-microglobulin was observed both in the pre-eclamptic group (r = 0.79, p less than 0.001) and in the normal pregnant group (r = 0.58, p less than 0.05). Uric Acid 44-53 beta-2-microglobulin Homo sapiens 58-78
4062456-1 1985 Three patients with the syndrome of inappropriate secretion of antidiuretic hormone had elevated uric acid clearances. Uric Acid 97-106 arginine vasopressin Homo sapiens 63-83
3524980-2 1986 Insulin pretreatment eliminated the stimulatory effect of glutamine infusion on urinary uric acid excretion in the chicken fed a 5% protein diet, which resulted in no increase in urinary total nitrogen excretion by the infusion. Uric Acid 88-97 insulin Gallus gallus 0-7
3935101-8 1985 In endothelial cells of microvascular origin uric acid predominates by far as the final purine degradative because of the presence of xanthine dehydrogenase in these cells; in the macrovascular endothelium purine breakdown proceeds only to hypoxanthine, since xanthine dehydrogenase is lacking. Uric Acid 45-54 xanthine dehydrogenase Homo sapiens 134-156
2994686-2 1985 We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation. Uric Acid 37-49 interleukin 1 alpha Homo sapiens 147-166
3935101-8 1985 In endothelial cells of microvascular origin uric acid predominates by far as the final purine degradative because of the presence of xanthine dehydrogenase in these cells; in the macrovascular endothelium purine breakdown proceeds only to hypoxanthine, since xanthine dehydrogenase is lacking. Uric Acid 45-54 xanthine dehydrogenase Homo sapiens 260-282
4015200-4 1985 One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumatoid factor (RF). Uric Acid 58-74 myelin regulatory factor Mus musculus 123-125
4047319-3 1985 The results were as follows; The CSF uric acid level was markedly increased in direct proportion to neutrophilia in the CSF in the acute stage of postoperative meningitis. Uric Acid 37-46 colony stimulating factor 2 Homo sapiens 33-36
4047319-3 1985 The results were as follows; The CSF uric acid level was markedly increased in direct proportion to neutrophilia in the CSF in the acute stage of postoperative meningitis. Uric Acid 37-46 colony stimulating factor 2 Homo sapiens 120-123
4047319-4 1985 Some cases with postoperative meningitis had biphasic increasing pattern of the CSF uric acid level. Uric Acid 84-93 colony stimulating factor 2 Homo sapiens 80-83
4047319-5 1985 In 12 cases without postoperative meningitis the CSF uric acid level had been progressively reduced and then normalized until the fourth day after operation. Uric Acid 53-62 colony stimulating factor 2 Homo sapiens 49-52
4047319-6 1985 The factors contributing to the increase of the uric acid in CSF under the condition of postoperative meningitis were thought to be 1) increased permeability of the blood-CSF barrier, 2) neutrophilia in the CSF and increase of the nucleic acid due to it, 3) increase of hypoxanthine, xanthine or xanthine oxidase activity in the central nervous system and 4) dysfunction of the CSF dynamics. Uric Acid 48-57 colony stimulating factor 2 Homo sapiens 61-64
4047319-6 1985 The factors contributing to the increase of the uric acid in CSF under the condition of postoperative meningitis were thought to be 1) increased permeability of the blood-CSF barrier, 2) neutrophilia in the CSF and increase of the nucleic acid due to it, 3) increase of hypoxanthine, xanthine or xanthine oxidase activity in the central nervous system and 4) dysfunction of the CSF dynamics. Uric Acid 48-57 colony stimulating factor 2 Homo sapiens 171-174
4047319-6 1985 The factors contributing to the increase of the uric acid in CSF under the condition of postoperative meningitis were thought to be 1) increased permeability of the blood-CSF barrier, 2) neutrophilia in the CSF and increase of the nucleic acid due to it, 3) increase of hypoxanthine, xanthine or xanthine oxidase activity in the central nervous system and 4) dysfunction of the CSF dynamics. Uric Acid 48-57 colony stimulating factor 2 Homo sapiens 171-174
4047319-6 1985 The factors contributing to the increase of the uric acid in CSF under the condition of postoperative meningitis were thought to be 1) increased permeability of the blood-CSF barrier, 2) neutrophilia in the CSF and increase of the nucleic acid due to it, 3) increase of hypoxanthine, xanthine or xanthine oxidase activity in the central nervous system and 4) dysfunction of the CSF dynamics. Uric Acid 48-57 colony stimulating factor 2 Homo sapiens 171-174
4047319-0 1985 [Clinical value of the sequential study of the uric acid level in the CSF in patients with postoperative meningitis]. Uric Acid 47-56 colony stimulating factor 2 Homo sapiens 70-73
4047319-1 1985 In this study we discuss the clinical value of the sequential measurement of the CSF uric acid and CSF cells in patients with postoperative acute meningitis. Uric Acid 85-94 colony stimulating factor 2 Homo sapiens 81-84
4047319-2 1985 CSF was investigated for uric acid and cells in 10 cases with postoperative meningitis and 12 cases without it for the control group. Uric Acid 25-34 colony stimulating factor 2 Homo sapiens 0-3
2986713-1 1985 The reactivities of myeloperoxidase-H2O2-Cl- and sodium hypochlorite with amino acids, uric acid, NADH, ascorbic acid, ADP, albumin, haemoglobin, alpha 1-antitrypsin and some hydroxyl radical scavengers have been compared. Uric Acid 87-96 myeloperoxidase Homo sapiens 20-35
4005552-2 1985 This peak is increased by microinfusion of uric acid or xanthine oxidase (which enhances conversion of hypoxanthine and xanthine to uric acid) and is decreased or eliminated by microinfusion of uricase. Uric Acid 132-141 urate oxidase Rattus norvegicus 194-201
3838707-2 1985 Simultaneously, xanthine dehydrogenase is converted to xanthine oxidase, an enzyme that converts hypoxanthine to xanthine, and xanthine to uric acid, producing a superoxide anion for each molecule of hypoxanthine or xanthine oxidized. Uric Acid 139-148 xanthine dehydrogenase Canis lupus familiaris 16-38
4071531-3 1985 Therefore, uricase which is present in normal activities is supplied only to a limited extent with uric acid for the transformation into the easily soluble allantoin. Uric Acid 99-108 urate oxidase Canis lupus familiaris 11-18
3899461-5 1985 The correlation of initial pressure with plasma insulin remained significant even when allowing for age, surface area, BMI, and plasma concentrations of glucose, urea, creatinine, sodium and urate. Uric Acid 191-196 insulin Homo sapiens 48-55
6083820-2 1984 The separation between DOPAC and 5HIAA oxidation is improved and the size of the 5HIAA peak decreased by the removal of uric acid using the enzyme uricase indicating that uric acid oxidation may contribute to the oxidation peak at + 300 mV. Uric Acid 120-129 urate oxidase Rattus norvegicus 147-154
6509051-1 1984 Using mouse small intestine brush-border membrane vesicles virtually free of xanthine oxidase (EC 1.2.3.2) and free of uricase (EC 1.7.3.3) the uptake of the purines uric acid, xanthine and hypoxanthine have been studied. Uric Acid 166-175 xanthine dehydrogenase Mus musculus 77-93
6509051-1 1984 Using mouse small intestine brush-border membrane vesicles virtually free of xanthine oxidase (EC 1.2.3.2) and free of uricase (EC 1.7.3.3) the uptake of the purines uric acid, xanthine and hypoxanthine have been studied. Uric Acid 166-175 urate oxidase Mus musculus 119-126
6083820-2 1984 The separation between DOPAC and 5HIAA oxidation is improved and the size of the 5HIAA peak decreased by the removal of uric acid using the enzyme uricase indicating that uric acid oxidation may contribute to the oxidation peak at + 300 mV. Uric Acid 171-180 urate oxidase Rattus norvegicus 147-154
6321074-2 1984 It has recently been proposed that an important source of superoxide anion during the respiratory burst that stimulates murine macrophages is the sequential metabolism of adenosine via adenosine deaminase and xanthine oxidase to uric acid. Uric Acid 229-238 xanthine dehydrogenase Mus musculus 209-225
6517491-1 1984 A spectrophotometric method for the determination of serum uric acid based on the oxidation of 2,2"-azino-di(3-ethylbenzthiazoline-6-sulphonate) by use of uricase and peroxidase has already been reported. Uric Acid 59-68 urate oxidase (pseudogene) Homo sapiens 155-162
6210015-1 1984 We describe evidence that serum samples from patients with chronic renal failure possess a constituent that interferes with the measurement of uric acid when using a method employing uricase with peroxidase-assisted detection of the hydrogen peroxide generated. Uric Acid 143-152 urate oxidase (pseudogene) Homo sapiens 183-190
6733923-0 1984 Technicon SMAC methods for uric acid: uricase and phosphotungstate compared. Uric Acid 27-36 diablo IAP-binding mitochondrial protein Homo sapiens 10-14
6685457-8 1983 Uricase activity was inhibited strongly by xanthine, which was competitive with respect to uric acid (Ki = 10 microM). Uric Acid 91-100 uricase-2 isozyme 1 Glycine max 0-7
6367368-0 1984 Increased plasma vasopressin and serum uric acid in the low renin type of essential hypertension. Uric Acid 39-48 renin Homo sapiens 60-65
6367368-4 1984 In addition, the hypertensives had highly significantly increased serum uric acid (p less than 0.001) that correlated positively with venous vasopressin concentrations (p less than 0.05). Uric Acid 72-81 arginine vasopressin Homo sapiens 141-152
6367368-6 1984 The data also indicate that increased plasma vasopressin correlates with serum uric acid, most probably through increased tubular reabsorption of this acid. Uric Acid 79-88 arginine vasopressin Homo sapiens 45-56
6667755-8 1983 In IHP, the administration of PTH induced a small but significant decrease in serum uric acid levels with a coincidental increase in urinary uric acid excretion. Uric Acid 84-93 parathyroid hormone Homo sapiens 30-33
6667755-8 1983 In IHP, the administration of PTH induced a small but significant decrease in serum uric acid levels with a coincidental increase in urinary uric acid excretion. Uric Acid 141-150 parathyroid hormone Homo sapiens 30-33
6200805-3 1983 Additionally, by microinfusing uric acid or its metabolizing enzyme uricase, it is shown that uric acid oxidation contributes to about 30% of the height of peak 3 measured in the rat striatum in vivo. Uric Acid 94-103 urate oxidase Rattus norvegicus 68-75
6614081-5 1983 The group of patients with mild PIH had significantly higher mean arterial blood pressures and uric acid levels (p less than 0.001). Uric Acid 95-104 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 32-35
6414723-3 1983 Using hepatocyte suspension and homogenized liver, it has been shown that prenatal activation of xanthine dehydrogenase results in increased rate of uric acid formation from nucleic acids and purine derivatives, but not from amino acids. Uric Acid 149-158 xanthine dehydrogenase Homo sapiens 97-119
6887165-0 1983 Effect of IgG and C-reactive protein on complement depletion by monosodium urate crystals. Uric Acid 64-80 C-reactive protein Homo sapiens 18-36
6309197-5 1983 These data confirm consensual relation between urinary uric acid and cAMP excretion, but the exact mechanism of this relation remains unexplained. Uric Acid 55-64 cathelicidin antimicrobial peptide Homo sapiens 69-73
6187611-4 1983 Compared with the controls, the entire PIH group was found to have significantly lower AT III values (P less than 0.05), more positive protamine sulphate tests (P less than 0.025), and higher plasma urate concentrations (P less than 0.01), but increased BTG values were more often observed than abnormal coagulation tests. Uric Acid 199-204 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 39-42
6407025-1 1983 The activity of hypoxanthine/guanine phosphoribosyltransferase (HGPRT) was examined in the livers and kidneys of two genetic lines of chickens selected for different plasma uric acid levels. Uric Acid 173-182 hypoxanthine phosphoribosyltransferase 1 Gallus gallus 16-62
6407025-1 1983 The activity of hypoxanthine/guanine phosphoribosyltransferase (HGPRT) was examined in the livers and kidneys of two genetic lines of chickens selected for different plasma uric acid levels. Uric Acid 173-182 hypoxanthine phosphoribosyltransferase 1 Gallus gallus 64-69
6869816-3 1983 Xanthine formed from guanine by guanase is oxidized to uric acid and hydrogen peroxide by xanthine oxidase, and the hydrogen peroxide produced is determined by an oxidative-coupling reaction with 3-methyl-2-benzothiazolinone hydrazone and N,N-diethylaniline mediated by peroxidase. Uric Acid 55-64 guanine deaminase Homo sapiens 32-39
16662921-9 1983 These data suggest that peroxisomes, containing uricase and catalase for conversion of uric acid to allantoin, are present only in the uninfected cells of soybean nodules. Uric Acid 87-96 catalase-3 Glycine max 60-68
6137054-2 1983 The alcohol non-user groups and the individuals with low GGT had significantly lower mean values of relative body weight, pulse, systolic and diastolic blood pressure, haematocrit, serum urate, triglyceride, cholesterol, and zero and 120 min blood glucose than individuals with elevated GGT and alcohol overconsumption. Uric Acid 187-192 gamma-glutamyltransferase light chain family member 3 Homo sapiens 57-60
6130890-2 1983 A single intraportal injection of insulin remarkably stimulated uric acid production in the chicken infused with ammonium acetate and significantly depressed the increase in plasma glutamine concentration by the infusion of ammonia (P less than 0.01 at 20 min, P less than 0.05 at 40 min after the start of infusion). Uric Acid 64-73 insulin Gallus gallus 34-41
6130890-6 1983 The depressive effect of insulin on the increase in plasma glutamine concentration by ammonia may be due to the acceleration by insulin of incorporation of glutamine into biosynthetic pathway of uric acid in the chicken. Uric Acid 195-204 insulin Gallus gallus 25-32
6130890-6 1983 The depressive effect of insulin on the increase in plasma glutamine concentration by ammonia may be due to the acceleration by insulin of incorporation of glutamine into biosynthetic pathway of uric acid in the chicken. Uric Acid 195-204 insulin Gallus gallus 128-135
6751647-9 1982 Uric acid excretion rate rose remarkably after nifedipine and the magnitude of the changes seemed intimately related to the basal level of RVR. Uric Acid 0-9 nuclear receptor subfamily 1 group D member 2 Homo sapiens 139-142
6983877-4 1982 Fasting plasma concentrations of LDL-C were most strongly and consistently associated in each gender with age, the Quetelet Index of body mass, the number of cigarettes smoked per day, systolic blood pressure, and the levels of plasma glucose and uric acid (all positive associations); and with height and bilirubin levels (both negative associations). Uric Acid 247-256 component of oligomeric golgi complex 2 Homo sapiens 33-38
6217925-3 1982 In all subjects studied there was a positive correlation between the erythrocyte adenosine deaminase activity and plasma urate concentration (r = 0.488, p less than 0.005). Uric Acid 121-126 adenosine deaminase Homo sapiens 81-100
6217925-5 1982 The results suggest that the increase of plasma urate concentrations is a consequence of the increase in adenosine deaminase activity in Down"s syndrome patients. Uric Acid 48-53 adenosine deaminase Homo sapiens 105-124
7085543-2 1982 In the method, uricase is used to decompose the uric acid; the reaction is monitored with an oxygen-sensitive electrode. Uric Acid 48-57 urate oxidase (pseudogene) Homo sapiens 15-22
6749358-0 1982 Activation of the fifth component of human complement (C5) induced by monosodium urate crystals: C5 convertase assembly on the crystal surface. Uric Acid 70-86 complement C5 Homo sapiens 43-57
7107209-0 1982 Abnormality in renal urate handling in the syndrome of inappropriate secretion of antidiuretic hormone. Uric Acid 21-26 arginine vasopressin Homo sapiens 82-102
7186433-1 1982 The uric acid peak among the compounds in aqueous humor separated by high pressure liquid chromatography was identified by its retention time, the UV absorbance characteristics, and the effect of uricase. Uric Acid 4-13 urate oxidase (pseudogene) Homo sapiens 196-203
7061920-4 1982 The effect of Tri and its metabolites on crystal formation has been measured in the calcium oxalate monohydrate, hydroxyapatite, and uric acid crystal systems. Uric Acid 133-142 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 14-17
6762265-5 1982 In the PIH group there was a negative correlation between PRA and blood uric acid. Uric Acid 72-81 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 7-10
18927832-0 1982 Two-point kinetic determination of uric acid in serum with uricase, catalase and aldehyde dehydrogenase on the KONE CD analyser. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 59-66
7128110-7 1982 Enzymes directly involved in urate synthesis from these amino acids increase up to 12-fold on the high-protein diet; only amidophosphoribosyltransferase activity appears to be rate-limiting for urate synthesis. Uric Acid 194-199 phosphoribosyl pyrophosphate amidotransferase Gallus gallus 122-152
18927832-0 1982 Two-point kinetic determination of uric acid in serum with uricase, catalase and aldehyde dehydrogenase on the KONE CD analyser. Uric Acid 35-44 catalase Homo sapiens 68-76
24233654-1 1981 The evaluation of a method for the estimation of serum urate using immobilized uricase is described, the resultant hydrogen peroxide produced being measured by the oxidative coupling of 3,5-dichloro-2-hydroxybenzenesulfonate and 4-aminophenazone in the presence of peroxidase.A continuous-flow analysis system incorporating the uricase tube was established, and the results obtained were correlated with an automated phosphotungstate method and with a manual uricase method employing an LKB 8600 Rate Reaction Analyser. Uric Acid 55-60 urate oxidase (pseudogene) Homo sapiens 328-335
6952874-1 1981 The course of the reaction sequence hypoxanthine leads to xanthine leads to uric acid, catalysed by the NAD+-dependent activity of xanthine oxidoreductase, was investigated under conditions either of immediate oxidation of the NADH formed or of NADH accumulation. Uric Acid 76-85 xanthine dehydrogenase Rattus norvegicus 131-154
7304984-0 1981 Uricase immobilized onto nylon tube for use in automated analysis of serum urate. Uric Acid 75-80 urate oxidase (pseudogene) Homo sapiens 0-7
7325230-8 1981 In inhibitor studies urate significantly depressed the uptake of [3H]PAH, and unlabeled PAH depressed the uptake of [14C]urate. Uric Acid 21-26 phenylalanine hydroxylase Sus scrofa 69-72
6945488-5 1981 For these patients the frequency of raised hypoxanthine and uric acid values in the CSF was twice as high as in Group A. Uric Acid 60-69 colony stimulating factor 2 Homo sapiens 84-87
6945488-11 1981 All these deceased patients showed extremely high hypoxanthine + xanthine and uric acid concentrations in their CSF. Uric Acid 78-87 colony stimulating factor 2 Homo sapiens 112-115
24233654-1 1981 The evaluation of a method for the estimation of serum urate using immobilized uricase is described, the resultant hydrogen peroxide produced being measured by the oxidative coupling of 3,5-dichloro-2-hydroxybenzenesulfonate and 4-aminophenazone in the presence of peroxidase.A continuous-flow analysis system incorporating the uricase tube was established, and the results obtained were correlated with an automated phosphotungstate method and with a manual uricase method employing an LKB 8600 Rate Reaction Analyser. Uric Acid 55-60 urate oxidase (pseudogene) Homo sapiens 79-86
24233654-1 1981 The evaluation of a method for the estimation of serum urate using immobilized uricase is described, the resultant hydrogen peroxide produced being measured by the oxidative coupling of 3,5-dichloro-2-hydroxybenzenesulfonate and 4-aminophenazone in the presence of peroxidase.A continuous-flow analysis system incorporating the uricase tube was established, and the results obtained were correlated with an automated phosphotungstate method and with a manual uricase method employing an LKB 8600 Rate Reaction Analyser. Uric Acid 55-60 urate oxidase (pseudogene) Homo sapiens 328-335
7457604-4 1981 The equation suggests that under normal conditions approximately 50% of the renal clearance of PAH or uric acid comes from the renal venous portal circulation, with the remaining 50% coming from the arterial circulation. Uric Acid 102-111 phenylalanine hydroxylase Gallus gallus 95-98
7214610-0 1980 A new method for the determination of serum uric acid by measuring allantoid produced by the action of uricase. Uric Acid 44-53 urate oxidase (pseudogene) Homo sapiens 103-110
6783754-1 1981 The effect of gold sodium thiomalate on C3 and factor B activation by monosodium urate monohydrate (MSUM) and zymosan was studied using a quantitative immunoelectrophoretic assay for complement activation. Uric Acid 70-98 complement C3 Homo sapiens 40-55
6783754-1 1981 The effect of gold sodium thiomalate on C3 and factor B activation by monosodium urate monohydrate (MSUM) and zymosan was studied using a quantitative immunoelectrophoretic assay for complement activation. Uric Acid 100-104 complement C3 Homo sapiens 40-55
7446528-4 1980 The TIC-1 variant is activated by adenine and inhibited by folic acid to the same extent as the type-A enzyme, while the stimulation of the activity of the TIC-1 enzyme by hypoxanthine and the inhibition of it by uric acid is similar to that for the B enzyme. Uric Acid 213-222 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Homo sapiens 4-9
7446528-4 1980 The TIC-1 variant is activated by adenine and inhibited by folic acid to the same extent as the type-A enzyme, while the stimulation of the activity of the TIC-1 enzyme by hypoxanthine and the inhibition of it by uric acid is similar to that for the B enzyme. Uric Acid 213-222 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Homo sapiens 156-161
7357749-0 1980 Determination of uric acid with uricase and peroxidase. Uric Acid 17-26 urate oxidase (pseudogene) Homo sapiens 32-39
7404061-0 1980 Primary overproduction of urate caused by a partial deficiency of hypoxanthine-guanine phosphoribosyl transferase. Uric Acid 26-31 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 66-113
6255057-2 1980 In combination with the enzymes nucleoside phosphorylase and xanthine oxidase, inosine, formed by hydrolysis of 5"-IMP by 5"-nucleotidase, is cleaved phosphorolytically to hypoxanthine, which is oxidized to uric acid. Uric Acid 207-216 5'-nucleotidase ecto Homo sapiens 122-137
573284-0 1979 Effect of acute administration of salmon and human calcitonin on blood urate and renal excretion of uric acid in patients with Paget"s disease of bone. Uric Acid 71-76 calcitonin related polypeptide alpha Homo sapiens 51-61
6252672-4 1980 Reversely, PTH injection significantly increases uricosuria suggesting interrelated secretion of uric acid and cAMP of the proximal tubules. Uric Acid 97-106 parathyroid hormone Homo sapiens 11-14
7353268-1 1980 A new direct colorimetric procedure for uric acid assay in serum or urine is described, utilizing a 3,5-dichloro-2-hydroxybenzene sulfonic acid/4-aminophenazone chromogenic system in the presence of horseradish peroxidase and uricase from Aspergillus flavus. Uric Acid 40-49 urate oxidase (pseudogene) Homo sapiens 226-233
573284-0 1979 Effect of acute administration of salmon and human calcitonin on blood urate and renal excretion of uric acid in patients with Paget"s disease of bone. Uric Acid 100-109 calcitonin related polypeptide alpha Homo sapiens 51-61
573284-3 1979 Our results suggest that the hypouricemia observed during CT treatment is related, at least in part to a direct action on the renal handling of uric acid. Uric Acid 144-153 calcitonin related polypeptide alpha Homo sapiens 58-60
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 117-122 calcitonin related polypeptide alpha Homo sapiens 27-37
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 117-122 calcitonin related polypeptide alpha Homo sapiens 39-41
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 117-122 calcitonin related polypeptide alpha Homo sapiens 64-66
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 174-183 calcitonin related polypeptide alpha Homo sapiens 27-37
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 174-183 calcitonin related polypeptide alpha Homo sapiens 39-41
573284-1 1979 The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. Uric Acid 174-183 calcitonin related polypeptide alpha Homo sapiens 64-66
455692-0 1979 Hyperxanthinemia interferes with serum uric acid determinations by the uricase method. Uric Acid 39-48 urate oxidase (pseudogene) Homo sapiens 71-78
455692-2 1979 These markedly above-normal values for xanthine led to spuriously low values for serum uric acid as measured by the uricase method. Uric Acid 87-96 urate oxidase (pseudogene) Homo sapiens 116-123
455692-3 1979 Rapid tumor lysis in patients who are receiving allopurinol may lead to marked hyperxanthinemia, which in turn may obscure hyperuricemia in such patients when the uricase method is used for uric acid analysis. Uric Acid 190-199 urate oxidase (pseudogene) Homo sapiens 163-170
454500-0 1979 Urate binding to serum albumin: lack of influence on renal clearance of uric acid. Uric Acid 0-5 albumin Homo sapiens 23-30
583329-2 1979 The developed method was constructed mainly from the following successive steps: (1) conversion of the oxypurines to uric acid and hydrogen peroxidase by xanthine oxidase; (2) decomposition of the hydrogen peroxide by catalase and subsequent inactivation of this enzyme; (3) fluorometric measurement of the uric acid based on the coupled enzyme reaction of uricase and peroxidase. Uric Acid 117-126 urate oxidase Rattus norvegicus 357-364
583329-3 1979 In applying this method to a sample containing uric acid, preliminary removal of this uric acid was necessary and this was carried out by treating the sample with uricase, followed by subsequent inactivation of this enzyme. Uric Acid 47-56 urate oxidase Rattus norvegicus 163-170
583329-3 1979 In applying this method to a sample containing uric acid, preliminary removal of this uric acid was necessary and this was carried out by treating the sample with uricase, followed by subsequent inactivation of this enzyme. Uric Acid 86-95 urate oxidase Rattus norvegicus 163-170
454500-4 1979 We conclude from this study that urate binding to serum albumin is not an important determinant of the renal clearance of uric acid, and by inference there is no significant binding of urate to serum albumin in vivo. Uric Acid 33-38 albumin Homo sapiens 56-63
466770-0 1979 Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase. Uric Acid 44-53 urate oxidase (pseudogene) Homo sapiens 73-80
36100-2 1979 Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and nucleoside concentrations in plasma and urine reflect the severity of the enzymatic deficiency and b) structural alterations of the mutant enzymes result from structural gene mutations and demonstrate genetic heterogeneity in the disease purine nucleoside phosphorylase deficiency. Uric Acid 170-179 purine nucleoside phosphorylase Homo sapiens 87-118
36153-1 1979 Uricase (urate:oxygen oxidoreductase, EC 1.7.3.3) exposes a positional and steric specificity in the enzymic conversion of urate to allantoin. Uric Acid 9-14 urate oxidase (pseudogene) Homo sapiens 0-7
466770-0 1979 Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase. Uric Acid 44-53 catalase Homo sapiens 81-89
466770-1 1979 The enzymatic determination of serum uric acid by use of uricase, catalase, and aldehyde dehydrogenase according to Haeckel [J. Clin. Uric Acid 37-46 urate oxidase (pseudogene) Homo sapiens 57-64
488056-7 1979 The sensitivity of the method with xanthine as substrate can be doubled by the addition of uricase, which oxidizes uric acid to allantoin. Uric Acid 115-124 urate oxidase (pseudogene) Homo sapiens 91-98
759034-0 1979 Thymol is a suitable preservative for uric acid standards in the uricase technique. Uric Acid 38-47 urate oxidase (pseudogene) Homo sapiens 65-72
488057-4 1979 Xanthine, the product of the guanase reaction, is oxidized by xanthine oxidase, forming uric acid and hydrogen peroxide. Uric Acid 88-97 guanine deaminase Homo sapiens 29-36
699291-2 1978 Results of these uric acid analyses by use of immobilized uricase, in conjunction with peroxidase (EC 1.11.1.7) and aminophenazone-dichlorophenol in solution, are compared with those obtained with the same enzyme in solution by use of the uricase-PAP (peroxidase, 4-aminophenazone, dichlorophenol) method. Uric Acid 17-26 urate oxidase (pseudogene) Homo sapiens 58-65
709818-2 1978 In the assay mixture (0.10 ml of sample and 3.00 ml of reagent) the hydrogen peroxide produced from uric acid by uricase is coupled with p-hydroxybenzoate and 4-aminoantipyrine in the presence of peroxidase to form a colored complex, which is measured. Uric Acid 100-109 urate oxidase (pseudogene) Homo sapiens 113-120
641455-0 1978 [Adaptation of the SMAC for the determination of uric acid with an uricase/perioxidase procedure (author"s transl)]. Uric Acid 49-58 diablo IAP-binding mitochondrial protein Homo sapiens 19-23
659766-1 1978 To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA). Uric Acid 118-127 renin Homo sapiens 21-26
659766-5 1978 The serum uric acid level in high-renin essential hypertension was higher than in either the normal-renin or the low-renin type. Uric Acid 10-19 renin Homo sapiens 34-39
659766-5 1978 The serum uric acid level in high-renin essential hypertension was higher than in either the normal-renin or the low-renin type. Uric Acid 10-19 renin Homo sapiens 100-105
659766-5 1978 The serum uric acid level in high-renin essential hypertension was higher than in either the normal-renin or the low-renin type. Uric Acid 10-19 renin Homo sapiens 100-105
659766-7 1978 Apparently the close correlation between the renin-angiotensin system and the concentration of serum uric acid is related to changes in extracellular fluid volume, although an intrarenal effect of angiotensin II cannot be excluded. Uric Acid 101-110 renin Homo sapiens 45-50
656160-4 1978 This effect of aggregates on urate solubility was abolished by digestion of the aggregates with hyaluronic acid beta1 leads to 3 hydrolase. Uric Acid 29-34 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 112-117
580986-1 1978 A major limitation to single-cell protein (SCP) as a human food is its high nucleic acid content, the purine moiety of which is metabolised to uric acid. Uric Acid 143-152 solute carrier family 50 member 1 Homo sapiens 43-46
580986-2 1978 Rats given a Fusarium mould as a source of SCP in diets containing oxonate, a uricase inhibitor, showed elevated plasma and kidney uric acid concentrations after 21 d, which were related to the level of dietary mould. Uric Acid 131-140 cysteine-rich secretory protein 3 Rattus norvegicus 43-46
724059-0 1978 [Diagnostic value of the CSF uric acid level (author"s transl)]. Uric Acid 29-38 colony stimulating factor 2 Homo sapiens 25-28
724059-2 1978 The CSF uric acid level is thought to be the index of the turnover of the nucleic acid and the degree of the cellular destruction in the brain. Uric Acid 8-17 colony stimulating factor 2 Homo sapiens 4-7
724059-3 1978 CSF uric acid levels were investigated in normal controls (30 cases) and in patients with brain tumor (20 cases), microcephalus (8 cases) and craniostenosis (4 cases). Uric Acid 4-13 colony stimulating factor 2 Homo sapiens 0-3
724059-4 1978 The mean values and standard deviations of CSF uric acid levels in normal controls were as follows; Newborn--9 yrs 0.34 +/- 0.09 mg/dl; 10 yrs--19 yrs 0.50 +/- 0.18 mg/dl; 20 yrs--29 yrs 0.46 +/- 0.05 mg/dl; 30 yrs--39 yrs 0.35 +/- 0.10 mg/dl; 40 yrs--49 yrs 0.35 +/- 0.23 mg/dl. Uric Acid 47-56 colony stimulating factor 2 Homo sapiens 43-46
724059-6 1978 The increased CSF uric acid levels after the age of 50 is thought to be due to the cellular destruction in the brain. Uric Acid 18-27 colony stimulating factor 2 Homo sapiens 14-17
724059-7 1978 CSF uric acid levels increased in patients with highly malignant brain tumor such as grade 3 or 4 astrocytoma and sarcomatous meningioma, but were normal in patients with grade 2 astrocytoma and meningiomas of meingothelial or fibroblastic type. Uric Acid 4-13 colony stimulating factor 2 Homo sapiens 0-3
724059-8 1978 CSF uric acid levels decreased in patients with microcephalus, but were almost normal in patients with craniostenosis. Uric Acid 4-13 colony stimulating factor 2 Homo sapiens 0-3
724059-9 1978 There is a significant correlation between CSF uric acid levels and the degree of brain atrophy in infants. Uric Acid 47-56 colony stimulating factor 2 Homo sapiens 43-46
641455-1 1978 We describe the enzymatic determination of uric acid (uricase/peroxidase) with the SMAC system. Uric Acid 43-52 diablo IAP-binding mitochondrial protein Homo sapiens 83-87
367691-2 1978 A number of authors have tried to develop such a model by administering high doses of uric acid to various animal species (dog, rabbit, rat) but the potent liver uricase in these species prevented development of sustained hyperuricemia. Uric Acid 86-95 urate oxidase Rattus norvegicus 162-169
682521-6 1978 Further, we consider the application of the tracer urate uptake by erythrocytes as an aid in the early diagnosis of gout. Uric Acid 51-56 activation induced cytidine deaminase Homo sapiens 86-89
618654-0 1978 Values for uric acid in patients" sera as measured with SMAC (phosphotungstate) and AutoAnalyzer (uricase) Uric Acid 11-20 diablo IAP-binding mitochondrial protein Homo sapiens 56-60
627057-0 1978 Determination of uric acid on continuous-flow (AutoAnalyzer II and SMA) systems with a uricase/phenol/4-aminophenazone color test. Uric Acid 17-26 survival of motor neuron 1, telomeric Homo sapiens 47-70
627057-0 1978 Determination of uric acid on continuous-flow (AutoAnalyzer II and SMA) systems with a uricase/phenol/4-aminophenazone color test. Uric Acid 17-26 urate oxidase (pseudogene) Homo sapiens 87-94
627057-1 1978 This report describes a new specific colorimetric procedure for uric acid assay with AutoAnalyzer II and SMA (Technicon) systems, made specific by the application of uricase. Uric Acid 64-73 survival of motor neuron 1, telomeric Homo sapiens 85-108
627057-1 1978 This report describes a new specific colorimetric procedure for uric acid assay with AutoAnalyzer II and SMA (Technicon) systems, made specific by the application of uricase. Uric Acid 64-73 urate oxidase (pseudogene) Homo sapiens 166-173
115663-2 1978 After each transfusion with PNP-containing erythrocytes a decrease in accumulated nucleosides and their deoxy compounds was observed, whereas uric acid excretion and serum uric acid increased. Uric Acid 142-151 purine nucleoside phosphorylase Homo sapiens 28-31
115663-2 1978 After each transfusion with PNP-containing erythrocytes a decrease in accumulated nucleosides and their deoxy compounds was observed, whereas uric acid excretion and serum uric acid increased. Uric Acid 172-181 purine nucleoside phosphorylase Homo sapiens 28-31
367691-9 1978 The ideal uricase inhibitor for induction of hyperuricemia would be one which is irreversible, noncompetitive, and relatively nontoxic, so that its activity would be independent of high levels of uric acid, and effective inhibition could be attained at low dosage levels. Uric Acid 196-205 urate oxidase Rattus norvegicus 10-17
921826-1 1977 Monosodium urate (MSU) crystals induced prompt release of lysozyme, and slower release of beta-glucuronidase, alpha-mannosidase, and lactic dehydrogenase (LDH) from polymorphonuclear leukocytes. Uric Acid 0-16 glucuronidase beta Homo sapiens 90-108
729538-1 1978 A sensitive and precise assay of guanase was based on the conversion of 14C-guanine to uric acid in the presence of excess xanthine oxidase. Uric Acid 87-96 guanine deaminase Rattus norvegicus 33-40
619042-2 1978 Nucleoside phosphorylase, xanthine dehydrogenase, adenylosuccinate synthetase and adenosine kinase correlated positively with protein intake and uric acid production. Uric Acid 145-154 xanthine dehydrogenase Gallus gallus 26-48
619042-2 1978 Nucleoside phosphorylase, xanthine dehydrogenase, adenylosuccinate synthetase and adenosine kinase correlated positively with protein intake and uric acid production. Uric Acid 145-154 adenosine kinase Gallus gallus 82-98
619042-3 1978 Adenosine deaminase, 5"-nucleotidase (AMP), adenylate deaminase and adenine phosphoribosyltransferase correlated negatively with protein intake and uric acid production. Uric Acid 148-157 adenosine deaminase Gallus gallus 0-19
619042-3 1978 Adenosine deaminase, 5"-nucleotidase (AMP), adenylate deaminase and adenine phosphoribosyltransferase correlated negatively with protein intake and uric acid production. Uric Acid 148-157 adenine phosphoribosyltransferase Gallus gallus 68-101
619042-5 1978 The ratio of adenosine kinase to adenosine deaminase correlated positively with protein intake and uric acid production. Uric Acid 99-108 adenosine kinase Gallus gallus 13-29
619042-5 1978 The ratio of adenosine kinase to adenosine deaminase correlated positively with protein intake and uric acid production. Uric Acid 99-108 adenosine deaminase Gallus gallus 33-52
921826-1 1977 Monosodium urate (MSU) crystals induced prompt release of lysozyme, and slower release of beta-glucuronidase, alpha-mannosidase, and lactic dehydrogenase (LDH) from polymorphonuclear leukocytes. Uric Acid 18-21 glucuronidase beta Homo sapiens 90-108
15103-7 1977 Parathyroid hormone and 10(-4) M adenosine 3":5"-monophosphate increased the uric acid uptake rate when preincubated with the tubules for 130 minutes before the addition of uric acid. Uric Acid 77-86 parathyroid hormone Oryctolagus cuniculus 0-19
16018-9 1977 The high glutamine synthetase activity (40:1) suggests that mitochondrial catabolism of glutamine is minimal, freeing most of the glutamine synthesized for purine (uric acid) biosynthesis. Uric Acid 164-173 glutamate-ammonia ligase Homo sapiens 9-29
613363-0 1977 [Automatic determination of uric acid with Morin and Prox method (author"s transl)]. Uric Acid 28-37 pyruvate dehydrogenase complex component X Homo sapiens 53-57
15103-7 1977 Parathyroid hormone and 10(-4) M adenosine 3":5"-monophosphate increased the uric acid uptake rate when preincubated with the tubules for 130 minutes before the addition of uric acid. Uric Acid 173-182 parathyroid hormone Oryctolagus cuniculus 0-19
837524-0 1977 A precise semi-automated uricase method for determining uric acid in serum or urine. Uric Acid 56-65 urate oxidase (pseudogene) Homo sapiens 25-32
17387-2 1977 The kinetic properties of the 5"-nucleotidase (EC 3.1.3.5) present in the cytosol of rat liver were investigated in relation to the conversion of adenine nucleotides into uric acid, with particular reference to the stimulation of this process by fructose. Uric Acid 171-180 5' nucleotidase, ecto Rattus norvegicus 30-45
844191-1 1977 Xanthine oxidase and guanase activities in normal and psoriatic epidermis were demonstrated and accurately assayed by the new micro-assay methods which rely on the isolation of 14C-labelled end-products, xanthine and uric acid, from the substrates, hypoxanthine and guanine, by electrophoresis on cellulose acetate membrane using 0.1 M borate buffer, pH 9.0. Uric Acid 217-226 guanine deaminase Homo sapiens 21-28
837524-2 1977 A semi-automated uricase method is described for measuring uric acid in serum or urine directly at 292 nm at reduced cost. Uric Acid 59-68 urate oxidase (pseudogene) Homo sapiens 17-24
939064-0 1976 Effect of vasopressin on uric acid excretion: evidence for distal nephron reabsorption of urate in man. Uric Acid 25-34 arginine vasopressin Homo sapiens 10-21
1277525-2 1976 Hydrogen peroxide, formed when uric acid is oxidized in the presence of uricase, oxidatively couples two molecules of p-hydroxyphenylacetic acid in the presence of peroxidase to produce a highly fluorescent compound. Uric Acid 31-40 urate oxidase (pseudogene) Homo sapiens 72-79
559302-6 1977 The specific activity of the purified uricase was 19.8 U/mg using either "urate" adsorbent. Uric Acid 74-79 urate oxidase Bos taurus 38-45
1016916-1 1976 The 5"-phosphomonoesterase activity of 5"-nucleotidase (EC 3.1.3.5) and alkaline phosphatase (EC 3.1.3.5) participates in the catabolism of purine ribonucleotides to uric acid in humans. Uric Acid 166-175 5'-nucleotidase ecto Homo sapiens 39-54
939064-2 1976 When changes in urine flow rate were induced by vasopressin administration in eight subjects, urate excretion decreased by a mean of 14% and was positively correlated with urine flow rate (r = 0.88, P less than 0.01). Uric Acid 94-99 arginine vasopressin Homo sapiens 48-59
939064-8 1976 Urate retention after vasopressin was entirely attributed to a decrease in pyrazinamide-suppressible urate excretion, consistent with either decreased secretion or enhanced post-secretory reabsorption of urate. Uric Acid 101-106 arginine vasopressin Homo sapiens 22-33
938983-3 1976 Reduction in blood pressure in eight low renin patients who showed smaller changes in plasma renin activity and uric acid was not significant at 2 weeks but significant after 12 weeks of treatment. Uric Acid 112-121 renin Homo sapiens 41-46
1253916-0 1976 Effect of fructose administration on serum urate levels in the uricase inhibited rat. Uric Acid 43-48 urate oxidase Rattus norvegicus 63-70
932643-3 1976 The sequence of reactions catalyzed by uricase, catalase and aldehyde dehydrogenase for determination of the uric acid concentration was evaluated for human serum and urine samples. Uric Acid 109-118 urate oxidase (pseudogene) Homo sapiens 39-46
932643-3 1976 The sequence of reactions catalyzed by uricase, catalase and aldehyde dehydrogenase for determination of the uric acid concentration was evaluated for human serum and urine samples. Uric Acid 109-118 catalase Homo sapiens 48-56
1249054-9 1976 These results indicate that the mitochondrial glutamine synthetase present in uricotelic species represents the primary ammonia detoxication reaction in that ammonia released intramitochondrially during amino acid catabolism is converted to glutamine for efflux to the cytosol where it may serve as a substrate for purine (uric acid) biosynthesis. Uric Acid 323-332 glutamate-ammonia ligase Homo sapiens 46-66
7705-0 1976 Vasopressin-stimulated movement of drugs and uric acid across the toad urinary bladder. Uric Acid 45-54 arginine vasopressin Homo sapiens 0-11
1026125-2 1976 The hydrogen peroxide formed when uric acid is oxidised by uricase, condenses by oxidation two molecules of p-hydroxyphenil-acetic acid in the presence of peroxidase. Uric Acid 34-43 urate oxidase (pseudogene) Homo sapiens 59-66
22797-2 1976 An increased supply of endogenous uric acid by reduced transformation of uric acid to allantoin and decreased uricase activity in the liver was assumed. Uric Acid 34-43 urate oxidase Rattus norvegicus 110-117
1211498-3 1975 Appearance and peak excretion of urate in the experimental but not in the contralateral kidney preceded inulin and coincided with PAH, indicating proximal permeability to urate. Uric Acid 33-38 phenylalanine hydroxylase Rattus norvegicus 130-133
1244565-1 1976 In normal persons, a decrease in urine flow following the injection of small amounts of vasopressin was accompanied by a significant decrease in the clearance and excretion of urate. Uric Acid 176-181 arginine vasopressin Homo sapiens 88-99
1201124-5 1975 The results of the flow rate and vasopressin studies are consistent with the hypothesis that urate reabsorption occurs in both the distal and the proximal tubule in man. Uric Acid 93-98 arginine vasopressin Homo sapiens 33-44
4462579-5 1974 Urate synthesis from glycine, glutamine, NH(4)Cl, asparagine, alanine, histidine and a mixture of 21 amino acids was obtained on inclusion of insulin in the perfusion medium. Uric Acid 0-5 insulin Gallus gallus 142-149
171639-7 1975 The uric acid concentration was significantly increased in plasma from chicks fed the high protein diets which suggests that D-3-phosphoglycerate dehydrogenase, phosphoserine phosphatase and serine hydroxymethyltransferase activities were increased because of the high requirement for glycine in uric acid formation. Uric Acid 4-13 phosphoglycerate dehydrogenase Gallus gallus 125-159
1159075-0 1975 Enzymatic degradation of uric acid by uricase-loaded human erythrocytes. Uric Acid 25-34 urate oxidase (pseudogene) Homo sapiens 38-45
1159075-2 1975 Uricase is shown to be active within the erythrocytes and to degrade uric acid as rapidly as it enters the cells when high intracellular enzyme concentrations are employed. Uric Acid 69-78 urate oxidase (pseudogene) Homo sapiens 0-7
167718-4 1975 When H2O2 production was stimulated by urate infusion, almost all of the H2O2 produced by the uricase reaction was decomposed by the catalase reaction. Uric Acid 39-44 catalase Rattus norvegicus 133-141
4814977-0 1974 Urate crystal arthritis in animals lacking Hageman factor. Uric Acid 0-5 coagulation factor XII Homo sapiens 43-57
4408019-0 1974 Displacement by uricosuric agents of sodium urate bound to human serum albumin. Uric Acid 37-49 albumin Homo sapiens 65-78
28603927-1 1971 The urate-binding alpha1-2 globulin has been isolated from human plasma in a highly purified state. Uric Acid 4-9 adrenoceptor alpha 1D Homo sapiens 18-26
4727817-0 1973 Uric acid nephropathy in shocked rats after blocking of uricase activity with triazine compounds. Uric Acid 0-9 urate oxidase Rattus norvegicus 56-63
4663631-0 1972 [Enlarged uric acid level in Erb"s progressive muscular dystrophy]. Uric Acid 10-19 estrogen receptor 2 Homo sapiens 29-32
5425366-0 1970 Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro. Uric Acid 72-81 albumin Homo sapiens 97-104
5451915-10 1970 It is suggested that GSH oxidation by homogenate is linked through glutathione peroxidase to the reaction of endogenous substrate with supernatant xanthine oxidase and of the uric acid formed with peroxisomal urate oxidase. Uric Acid 175-184 urate oxidase Rattus norvegicus 209-222
4674304-1 1972 Alveolar macrophages acquired the capacity to oxidize uric acid after exposure to uricase. Uric Acid 54-63 urate oxidase (pseudogene) Homo sapiens 82-89
5456794-4 1970 A progressive increase in PPL concentration results in a corresponding increase in urate solubility. Uric Acid 83-88 periplakin Homo sapiens 26-29
28603927-3 1971 The urate-binding alpha1-2 globulin is a rod-shaped glycoprotein with a molecular weight of 67000 as determined by dodecyl sulphate polyacrylamide gel electrophoresis and an isoelectric point of pH 4.6. Uric Acid 4-9 adrenoceptor alpha 1D Homo sapiens 18-26
28603927-7 1971 Further work is required in order to determine the number of binding sites for uric acid on the protein molecule.-The urate-binding alpha1-2 globulin does not seem to be identical to any previously characterized protein from human blood. Uric Acid 79-88 adrenoceptor alpha 1D Homo sapiens 132-140
28603927-7 1971 Further work is required in order to determine the number of binding sites for uric acid on the protein molecule.-The urate-binding alpha1-2 globulin does not seem to be identical to any previously characterized protein from human blood. Uric Acid 118-123 adrenoceptor alpha 1D Homo sapiens 132-140
14306889-0 1965 [ANALYSIS OF URIC ACID BY URICASE IN SERUM AND URINE]. Uric Acid 13-22 urate oxidase (pseudogene) Homo sapiens 26-33
5676523-5 1968 These patients have no discernable abnormality in uric acid production despite the finding that patients with a deficiency of a closely related enzyme, hypoxanthine-guanine phosphoribosyltransferase, invariably produce excessive quantities of uric acid. Uric Acid 243-252 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 152-198
6013862-0 1966 [Spa Treatment of increased uric acid and cholesterol levels]. Uric Acid 28-37 surfactant protein A2 Homo sapiens 1-4
5749591-0 1968 Determination of uric acid in avian excreta by the use of uricase and differential spectrophotometry. Uric Acid 17-26 urate oxidase (pseudogene) Homo sapiens 58-65
5948254-0 1966 The effect of small amounts of antidiuretic hormone on sodium and urate excretion in pregnancy. Uric Acid 66-71 arginine vasopressin Homo sapiens 31-51
14239199-0 1964 [DETERMINATION OF BLOOD URIC ACID IN NORMAL SUBJECTS BY THE URICASE METHOD; VARIATIONS AS A FUNCTION OF AGE AND SEX]. Uric Acid 24-33 urate oxidase (pseudogene) Homo sapiens 60-67
14267254-1 1965 I. ACTIVATION OF HAGEMAN FACTOR BY SODIUM URATE CRYSTALS. Uric Acid 35-47 coagulation factor XII Homo sapiens 17-31
13035285-0 1953 A new method for preparing a highly purified uricase suitable for uric acid determination by ultraviolet spectrophotometry. Uric Acid 66-75 urate oxidase (pseudogene) Homo sapiens 45-52
14392141-2 1955 Distribution of C14 in the urinary uric acid molecule. Uric Acid 35-44 galectin 1A Gallus gallus 16-19
13106045-0 1953 [Research on the ACTH-induced variations in blood iron in relation to the uric acid and creatinine content and the eosinophil count of the blood]. Uric Acid 74-83 proopiomelanocortin Homo sapiens 17-21
15436881-0 1950 The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. Uric Acid 84-93 proopiomelanocortin Homo sapiens 30-57
12999780-0 1952 Synthesis of aspartic acid-2, 3-C14-N15 and its conversion to uric acid in the pigeon. Uric Acid 62-71 PTOV1 extended AT-hook containing adaptor protein Homo sapiens 22-28
14889032-0 1951 The effects of ACTH and cortisone on the renal tubular transport of uric acid, phosphorus, and electrolytes in patients with normal renal and adrenal function. Uric Acid 68-77 proopiomelanocortin Homo sapiens 15-19
14799648-0 1950 Mechanism by which ACTH increases the excretion of urate. Uric Acid 51-56 proopiomelanocortin Homo sapiens 19-23
14790813-0 1950 Oxidation of uric acid and of alloxan by cytochrome c. Uric Acid 13-22 cytochrome c, somatic Homo sapiens 41-53
14802751-0 1950 Response of circulating eosinophiles and uric acid excretion to ACTH in geriatric patients. Uric Acid 41-50 proopiomelanocortin Homo sapiens 64-68
33900847-0 2021 High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. Uric Acid 5-14 FAT atypical cadherin 1 Homo sapiens 29-32
18865744-0 1948 Production of temporary diabetes mellitus in man with pituitary adrenocorticotropic hormone; relation to uric acid metabolism. Uric Acid 105-114 proopiomelanocortin Homo sapiens 64-91
33986829-4 2021 Additionally, the RT-qPCR results demonstrated that miR-770-5p expression was significantly increased and BAG5 expression was significantly decreased in uric acid (UA)-treated Min6 cells compared with control cells. Uric Acid 153-162 BCL2-associated athanogene 5 Mus musculus 106-110
33986829-4 2021 Additionally, the RT-qPCR results demonstrated that miR-770-5p expression was significantly increased and BAG5 expression was significantly decreased in uric acid (UA)-treated Min6 cells compared with control cells. Uric Acid 164-166 BCL2-associated athanogene 5 Mus musculus 106-110
33900847-0 2021 High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. Uric Acid 5-14 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-62
20344111-0 1947 Urinary uric acid-creatinine ratio following administration of pituitary adrenocorticotropic hormone (ACTH) as a simple test for adrenal cortical function. Uric Acid 8-17 proopiomelanocortin Homo sapiens 73-100
20344111-0 1947 Urinary uric acid-creatinine ratio following administration of pituitary adrenocorticotropic hormone (ACTH) as a simple test for adrenal cortical function. Uric Acid 8-17 proopiomelanocortin Homo sapiens 102-106
33986829-9 2021 The results demonstrated that UA treatment significantly reduced cell viability, increased cell apoptosis and reduced insulin secretion in Min6 cells compared with the control group. Uric Acid 30-32 insulin Homo sapiens 118-125
33986829-12 2021 In UA-treated pancreatic beta-cells, compared with the inhibitor control group, miR-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting BAG5. Uric Acid 3-5 microRNA 770 Homo sapiens 80-87
33986829-12 2021 In UA-treated pancreatic beta-cells, compared with the inhibitor control group, miR-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting BAG5. Uric Acid 3-5 insulin Homo sapiens 219-226
33986829-12 2021 In UA-treated pancreatic beta-cells, compared with the inhibitor control group, miR-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting BAG5. Uric Acid 3-5 BAG cochaperone 5 Homo sapiens 250-254
33900847-0 2021 High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. Uric Acid 5-14 mitogen-activated protein kinase 8 Homo sapiens 54-57
33677310-0 2021 Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis. Uric Acid 73-78 GLI family zinc finger 2 Homo sapiens 36-41
33677310-0 2021 Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis. Uric Acid 73-78 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 104-110
33677310-2 2021 Here, we explored the underlying mechanism of total glucosides of paeony (TGP) in MSU-induced inflammation of THP-1 macrophages in gouty arthritis. Uric Acid 82-85 GLI family zinc finger 2 Homo sapiens 110-115
33677310-7 2021 RESULTS: MSU-induced damage and inflammatory response in THP-1 macrophages were alleviated by the treatment of TGP in a dose-dependent manner. Uric Acid 9-12 GLI family zinc finger 2 Homo sapiens 57-62
33677310-0 2021 Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis. Uric Acid 73-78 microRNA 876 Homo sapiens 111-118
33677310-8 2021 Overexpression of NLRP3 or MALAT1 reversed the protective effects of TGP in MSU-induced THP-1 macrophages. Uric Acid 76-79 NLR family pyrin domain containing 3 Homo sapiens 18-23
33677310-0 2021 Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis. Uric Acid 73-78 NLR family pyrin domain containing 3 Homo sapiens 122-127
33677310-8 2021 Overexpression of NLRP3 or MALAT1 reversed the protective effects of TGP in MSU-induced THP-1 macrophages. Uric Acid 76-79 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 27-33
33677310-8 2021 Overexpression of NLRP3 or MALAT1 reversed the protective effects of TGP in MSU-induced THP-1 macrophages. Uric Acid 76-79 GLI family zinc finger 2 Homo sapiens 88-93
33677310-11 2021 TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 GLI family zinc finger 2 Homo sapiens 43-48
33930349-3 2021 Studies have shown that endogenous and exogenous pathogenic crystals, such as cholesterol and monosodium urate (MSU), and needle-like nanomaterials, such as multi-wall carbon nanotubes (MWCNT), induce the production of IL-1beta and play a critical role in the development of crystal-associated sterile inflammatory pathologies. Uric Acid 94-110 interleukin 1 alpha Mus musculus 219-227
33677310-11 2021 TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 80-86
33677310-11 2021 TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 microRNA 876 Homo sapiens 87-94
33677310-11 2021 TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 NLR family pyrin domain containing 3 Homo sapiens 98-103
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 toll like receptor 4 Homo sapiens 41-45
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 MYD88 innate immune signal transduction adaptor Homo sapiens 46-51
33930349-6 2021 In addition, IL-1beta production induced by cholesterol crystals and MSU crystals, but not by ATP or nigericin, was diminished. Uric Acid 69-72 interleukin 1 alpha Mus musculus 13-21
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 nuclear factor kappa B subunit 1 Homo sapiens 52-61
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 89-95
34057027-0 2021 Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death. Uric Acid 0-9 caspase 8 Rattus norvegicus 138-145
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 microRNA 876 Homo sapiens 96-103
33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 NLR family pyrin domain containing 3 Homo sapiens 107-112
33677310-13 2021 CONCLUSION: In conclusion, TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis and TLR4/MyD88/NF-kappaB pathway, suggesting that TGP was a promising active ingredient for gouty arthritis treatment. Uric Acid 42-45 GLI family zinc finger 2 Homo sapiens 70-75
33608866-0 2021 MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3. Uric Acid 51-67 NLR family, pyrin domain containing 3 Rattus norvegicus 127-132
33608866-9 2021 MSU increased the paw volume, gait score, inflammation in synovial tissues, increased the levels of IL-1beta, TNF-alpha, and articular elastase in rats. Uric Acid 0-3 interleukin 1 alpha Rattus norvegicus 100-108
33608866-9 2021 MSU increased the paw volume, gait score, inflammation in synovial tissues, increased the levels of IL-1beta, TNF-alpha, and articular elastase in rats. Uric Acid 0-3 tumor necrosis factor Rattus norvegicus 110-119
33608866-10 2021 MSU decreased the viability and increased the pyroptosis of FLSs, up-regulated the expressions of NLRP3, ASC, Cleaved Caspase-1, Cleaved N-terminal GSDMD, and IL-1beta, and down-regulated miR-223-3p expression in synovial tissues of rat joints and FLSs. Uric Acid 0-3 NLR family, pyrin domain containing 3 Rattus norvegicus 98-103
33608866-10 2021 MSU decreased the viability and increased the pyroptosis of FLSs, up-regulated the expressions of NLRP3, ASC, Cleaved Caspase-1, Cleaved N-terminal GSDMD, and IL-1beta, and down-regulated miR-223-3p expression in synovial tissues of rat joints and FLSs. Uric Acid 0-3 PYD and CARD domain containing Rattus norvegicus 105-108
33608866-10 2021 MSU decreased the viability and increased the pyroptosis of FLSs, up-regulated the expressions of NLRP3, ASC, Cleaved Caspase-1, Cleaved N-terminal GSDMD, and IL-1beta, and down-regulated miR-223-3p expression in synovial tissues of rat joints and FLSs. Uric Acid 0-3 gasdermin D Rattus norvegicus 148-153
33608866-10 2021 MSU decreased the viability and increased the pyroptosis of FLSs, up-regulated the expressions of NLRP3, ASC, Cleaved Caspase-1, Cleaved N-terminal GSDMD, and IL-1beta, and down-regulated miR-223-3p expression in synovial tissues of rat joints and FLSs. Uric Acid 0-3 interleukin 1 alpha Rattus norvegicus 159-167
33608866-13 2021 Besides, NLRP3 overexpression reversed the effects of miR-223-3p on MSU-induced FLSs. Uric Acid 68-71 NLR family, pyrin domain containing 3 Rattus norvegicus 9-14
33608866-13 2021 Besides, NLRP3 overexpression reversed the effects of miR-223-3p on MSU-induced FLSs. Uric Acid 68-71 microRNA 223 Rattus norvegicus 54-61
33608866-14 2021 MiR-223-3p inhibited pyroptosis in MSU-induced rats and FLSs by targeting NLRP3. Uric Acid 35-38 NLR family, pyrin domain containing 3 Rattus norvegicus 74-79
34057027-6 2021 Immunoblotting results showed that uric acid treatment elevated the expression level of p-p38 MAPK but did markedly reduce the protein levels of p-p44/42, compared with all the uric acid doses-treated VSMCs, especially at 1 h. Uric acid stimulation increased caspase-3 protein levels and decreased Bcl-xL, but did not alter caspase-8 protein expression at the same dose and time. Uric Acid 35-44 eukaryotic translation initiation factor 2 subunit gamma Rattus norvegicus 145-153
34057027-6 2021 Immunoblotting results showed that uric acid treatment elevated the expression level of p-p38 MAPK but did markedly reduce the protein levels of p-p44/42, compared with all the uric acid doses-treated VSMCs, especially at 1 h. Uric acid stimulation increased caspase-3 protein levels and decreased Bcl-xL, but did not alter caspase-8 protein expression at the same dose and time. Uric Acid 35-44 caspase 3 Rattus norvegicus 259-268
34057027-6 2021 Immunoblotting results showed that uric acid treatment elevated the expression level of p-p38 MAPK but did markedly reduce the protein levels of p-p44/42, compared with all the uric acid doses-treated VSMCs, especially at 1 h. Uric acid stimulation increased caspase-3 protein levels and decreased Bcl-xL, but did not alter caspase-8 protein expression at the same dose and time. Uric Acid 35-44 Bcl2-like 1 Rattus norvegicus 298-304
34053376-4 2021 EXPERT OPINION: Advances in molecular biology reveal that at the base of the inflammatory cascade, stimulated by MSU or CPP crystals, there are many complex cellular mechanisms mainly involving the NLRP3 inflammasome, the hallmark of autoinflammatory syndromes. Uric Acid 113-116 NLR family pyrin domain containing 3 Homo sapiens 198-203
34057027-6 2021 Immunoblotting results showed that uric acid treatment elevated the expression level of p-p38 MAPK but did markedly reduce the protein levels of p-p44/42, compared with all the uric acid doses-treated VSMCs, especially at 1 h. Uric acid stimulation increased caspase-3 protein levels and decreased Bcl-xL, but did not alter caspase-8 protein expression at the same dose and time. Uric Acid 35-44 caspase 8 Rattus norvegicus 324-333
34057027-6 2021 Immunoblotting results showed that uric acid treatment elevated the expression level of p-p38 MAPK but did markedly reduce the protein levels of p-p44/42, compared with all the uric acid doses-treated VSMCs, especially at 1 h. Uric acid stimulation increased caspase-3 protein levels and decreased Bcl-xL, but did not alter caspase-8 protein expression at the same dose and time. Uric Acid 227-236 eukaryotic translation initiation factor 2 subunit gamma Rattus norvegicus 145-153
33749747-2 2021 Allopurinol (AP), an inhibitor of uric acid (UA) synthesis, was reported to prevent liver damage in several liver diseases. Uric Acid 34-43 LIM homeobox protein 2 Mus musculus 13-15
33749747-2 2021 Allopurinol (AP), an inhibitor of uric acid (UA) synthesis, was reported to prevent liver damage in several liver diseases. Uric Acid 45-47 LIM homeobox protein 2 Mus musculus 13-15
34053424-10 2021 The activities of XOD were recovered to the normal level, reducing UA formation; the expression of URAT1, ABCG2, and GLUT9 returned to the normal level, resulting in an increase in renal urate excretion. Uric Acid 187-192 ATP binding cassette subfamily G member 2 Rattus norvegicus 106-111
34029542-4 2021 Our results showed that GAA improved renal damage by decreasing the serum levels of creatinine, urea, uric acid and alleviating kidney fibrosis. Uric Acid 102-111 glucosidase, alpha, acid Mus musculus 24-27
33749747-7 2021 The protective effect of AP on cholestatic liver injury was not attributable to the depletion of UA, because both exogenous and endogenous UA prevented liver injury in ANIT-treated mice via inhibition of NF-kB-mediated inflammation. Uric Acid 139-141 LIM homeobox protein 2 Mus musculus 25-27
34000416-3 2021 Xanthine oxidase is the rate-limiting enzyme that catalyzes the degradation of hypoxanthine and xanthine into uric acid. Uric Acid 110-119 xanthine dehydrogenase Mus musculus 0-16
34002852-0 2021 CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis. Uric Acid 76-79 CD300A molecule Mus musculus 0-6
34002852-4 2021 When compared to WT mice, CD300a-/- mice had persistent neutrophil influx till 24 h after MSU injection. Uric Acid 90-93 CD300A molecule Mus musculus 26-32
34002852-7 2021 This difference was reflected in the decline of efferocytic events in the synovial cavity of CD300a-/- mice 24 h after MSU injection. Uric Acid 119-122 CD300A molecule Mus musculus 93-99
34002852-9 2021 In conclusion, our results reveal an important role of CD300a in the control of leukocyte infiltration, IL-1beta production and caspase-8 cleavage in neutrophils, contributing to the resolution of inflammation triggered by MSU injection. Uric Acid 223-226 CD300a molecule Homo sapiens 55-61
34002852-9 2021 In conclusion, our results reveal an important role of CD300a in the control of leukocyte infiltration, IL-1beta production and caspase-8 cleavage in neutrophils, contributing to the resolution of inflammation triggered by MSU injection. Uric Acid 223-226 interleukin 1 alpha Homo sapiens 104-112
34002852-9 2021 In conclusion, our results reveal an important role of CD300a in the control of leukocyte infiltration, IL-1beta production and caspase-8 cleavage in neutrophils, contributing to the resolution of inflammation triggered by MSU injection. Uric Acid 223-226 caspase 8 Homo sapiens 128-137
33976226-4 2021 YAP deficiency in myeloid cells significantly attenuates LPS-induced systemic inflammation and monosodium urate (MSU) crystals-induced peritonitis. Uric Acid 95-111 Yes1 associated transcriptional regulator Homo sapiens 0-3
34007200-0 2021 microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3. Uric Acid 67-83 microRNA 223 Mus musculus 0-12
34007200-0 2021 microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3. Uric Acid 67-83 NLR family, pyrin domain containing 3 Mus musculus 106-111
34007200-6 2021 Results: MiR-223 was up-regulated in the early phase in BMDMs from WT mice after MSU challenge and decreased rapidly, and this was not observed in miR-223 KO mice in vitro. Uric Acid 81-84 microRNA 223 Mus musculus 9-16
34007200-11 2021 Besides, miR-223 level was down-regulated in gout patients and in HC exposed to MSU in vitro. Uric Acid 80-83 microRNA 223 Homo sapiens 9-16
33976226-4 2021 YAP deficiency in myeloid cells significantly attenuates LPS-induced systemic inflammation and monosodium urate (MSU) crystals-induced peritonitis. Uric Acid 113-116 Yes1 associated transcriptional regulator Homo sapiens 0-3
34010774-7 2021 Fascinatingly, the hybrid nanozyme can inhibit the formation of monosodium urate monohydrate effectively based on the architecture of ARP-PtNCs. Uric Acid 64-92 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 134-137
33933022-7 2021 Treatment with L-ca significantly reduced the serum BUN, creatinine, uric acid and MDA level and increased catalase, GPX and SOD compared to the MSG group. Uric Acid 69-78 protein tyrosine phosphatase, receptor type, C Rattus norvegicus 15-19
34025639-10 2021 Since uric acid is a ligand of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, TFGU was further validated to inhibit the activation of NLRP3 inflammasome by CPT-11. Uric Acid 6-15 NLR family, pyrin domain containing 3 Mus musculus 87-92
34025639-10 2021 Since uric acid is a ligand of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, TFGU was further validated to inhibit the activation of NLRP3 inflammasome by CPT-11. Uric Acid 6-15 NLR family, pyrin domain containing 3 Mus musculus 164-169
33938370-8 2022 Serum catestatin levels had positive correlations with systolic and diastolic blood pressure, urea, uric acid, and creatinine. Uric Acid 100-109 chromogranin A Homo sapiens 6-16
33647713-1 2021 INTRODUCTION: Interleukin-37(IL-37), a natural inhibitor of innate immunity, has been identified to protect against various inflammatory diseases, including monosodium urate (MSU)-induced inflammation. Uric Acid 157-173 interleukin 37 Homo sapiens 14-28
33021021-4 2021 Vasoconstriction was also attenuated in kidneys with URC as angiotensinogen levels were reduced. Uric Acid 53-56 angiotensinogen Homo sapiens 60-75
33931953-2 2021 Using a multifaceted approach, we aimed to characterize the relationship(s) between BCRP p.Q141K, the pharmacokinetics (PK) and pharmacodynamics (PD) of oxypurinol (the active metabolite of allopurinol), and serum uric acid (SUA) levels. Uric Acid 214-223 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 84-88
33931953-9 2021 Real-world data analyses showed that patients prescribed clinical inhibitors of BCRP have higher SUA levels than those that have not been prescribed inhibitors of BCRP, consistent with the idea that BCRP inhibitors phenocopy the effects of p.Q141K on uric acid levels. Uric Acid 251-260 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 80-84
33931953-10 2021 This study identified important covariates of oxypurinol PK/PD that could affect its efficacy for the treatment of gout as well as a potential side effect of BCRP inhibitors on increasing uric acid levels, which has not been described previously. Uric Acid 188-197 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 158-162
33933135-9 2021 Serum asprosin was found to be positively related with disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid, ACR, calcium channel blockers, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy, but negatively related with glomerular filtration rate, metformin, and acarbose therapy. Uric Acid 131-140 fibrillin 1 Homo sapiens 6-14
33647713-1 2021 INTRODUCTION: Interleukin-37(IL-37), a natural inhibitor of innate immunity, has been identified to protect against various inflammatory diseases, including monosodium urate (MSU)-induced inflammation. Uric Acid 157-173 interleukin 37 Homo sapiens 29-34
33647713-1 2021 INTRODUCTION: Interleukin-37(IL-37), a natural inhibitor of innate immunity, has been identified to protect against various inflammatory diseases, including monosodium urate (MSU)-induced inflammation. Uric Acid 175-178 interleukin 37 Homo sapiens 14-28
33647713-1 2021 INTRODUCTION: Interleukin-37(IL-37), a natural inhibitor of innate immunity, has been identified to protect against various inflammatory diseases, including monosodium urate (MSU)-induced inflammation. Uric Acid 175-178 interleukin 37 Homo sapiens 29-34
33094480-7 2021 Correlation analysis demonstrates that SeP is positively associated with NAFLD risk factors including body mass index, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and serum uric acid. Uric Acid 210-219 selenoprotein P Homo sapiens 39-42
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 66-82 NLR family, pyrin domain containing 3 Mus musculus 207-212
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 66-82 caspase 1 Mus musculus 256-265
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 66-82 interleukin 1 alpha Mus musculus 279-287
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 84-87 NLR family, pyrin domain containing 3 Mus musculus 207-212
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 84-87 caspase 1 Mus musculus 256-265
34047713-1 2021 Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages. Uric Acid 84-87 interleukin 1 alpha Mus musculus 279-287
33995019-7 2021 ELISAs kit were used to measure changes in levels of proinflammatory factors in rats with GA induced by MSU to demonstrate the efficacy of ARC in GA treatment. Uric Acid 104-107 nucleolar protein 3 Rattus norvegicus 139-142
31140315-2 2021 Xanthine oxidase (XO) catalyzes the formation of uric acid from xanthine, a critical metabolic pathway related to hyperuricemia and gout. Uric Acid 49-58 xanthine dehydrogenase Mus musculus 0-16
31140315-2 2021 Xanthine oxidase (XO) catalyzes the formation of uric acid from xanthine, a critical metabolic pathway related to hyperuricemia and gout. Uric Acid 49-58 xanthine dehydrogenase Mus musculus 18-20
33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Uric Acid 147-156 xanthine dehydrogenase Homo sapiens 9-12
33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Uric Acid 147-156 xanthine dehydrogenase Homo sapiens 33-55
33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Uric Acid 147-156 xanthine dehydrogenase Homo sapiens 57-60
33578127-4 2021 About XOR products, it should be considered that (i) uric acid is not only a proinflammatory agent, but also a fundamental antioxidant molecule in serum and (ii) XOR-derived ROS are essential to the inflammatory defensive response. Uric Acid 53-62 xanthine dehydrogenase Homo sapiens 6-9
33578127-4 2021 About XOR products, it should be considered that (i) uric acid is not only a proinflammatory agent, but also a fundamental antioxidant molecule in serum and (ii) XOR-derived ROS are essential to the inflammatory defensive response. Uric Acid 53-62 xanthine dehydrogenase Homo sapiens 162-165
33995019-12 2021 In vitro experiments showed that AA in ARC could effectively reduce expression of MAPK14, MMP9, and cyclooxygenase2 (PTGS2) in THP-1 cells stimulated by MSU, whereas it could significantly inhibit the mRNA expression of Caspase-1, spleen tyrosine kinase (SYK), and PTGS2. Uric Acid 153-156 activity regulated cytoskeleton associated protein Homo sapiens 39-42
33995019-12 2021 In vitro experiments showed that AA in ARC could effectively reduce expression of MAPK14, MMP9, and cyclooxygenase2 (PTGS2) in THP-1 cells stimulated by MSU, whereas it could significantly inhibit the mRNA expression of Caspase-1, spleen tyrosine kinase (SYK), and PTGS2. Uric Acid 153-156 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-122
33995019-13 2021 Animal experiments showed that a ARC aqueous extract could significantly reduce expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and intereleukin (IL)-18 in the serum of GA rats stimulated by MSU. Uric Acid 216-219 nucleolar protein 3 Rattus norvegicus 33-36
33995019-13 2021 Animal experiments showed that a ARC aqueous extract could significantly reduce expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and intereleukin (IL)-18 in the serum of GA rats stimulated by MSU. Uric Acid 216-219 tumor necrosis factor Rattus norvegicus 94-127
33995019-13 2021 Animal experiments showed that a ARC aqueous extract could significantly reduce expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and intereleukin (IL)-18 in the serum of GA rats stimulated by MSU. Uric Acid 216-219 interleukin 1 alpha Rattus norvegicus 129-151
33995019-13 2021 Animal experiments showed that a ARC aqueous extract could significantly reduce expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and intereleukin (IL)-18 in the serum of GA rats stimulated by MSU. Uric Acid 216-219 interleukin 18 Rattus norvegicus 157-177
33995019-15 2021 Conclusion: ARC treatment of GA may have the following mechanisms, ARC can reduce MSU crystal-induced joint swelling, reduce synovial tissue damage, and reduce the expression of inflammatory factors in serum. Uric Acid 82-85 nucleolar protein 3 Rattus norvegicus 12-15
33995019-15 2021 Conclusion: ARC treatment of GA may have the following mechanisms, ARC can reduce MSU crystal-induced joint swelling, reduce synovial tissue damage, and reduce the expression of inflammatory factors in serum. Uric Acid 82-85 nucleolar protein 3 Rattus norvegicus 67-70
33925441-0 2021 The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients. Uric Acid 10-19 CD79a molecule Homo sapiens 87-90
33460754-13 2021 CONCLUSION: Our data indicated that MSW protected rats from MSU-induced experimental gouty arthritis and IL-1beta/IL-6/STAT3 pathway played an essential role in the protective effect of MSU against GA. Uric Acid 186-189 interleukin 6 Rattus norvegicus 114-118
33902703-0 2021 Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1beta production. Uric Acid 54-63 cold inducible RNA binding protein Homo sapiens 0-34
33902703-0 2021 Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1beta production. Uric Acid 54-63 cold inducible RNA binding protein Homo sapiens 36-40
33902703-0 2021 Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1beta production. Uric Acid 54-63 interleukin 1 alpha Homo sapiens 72-80
33902703-4 2021 In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils. Uric Acid 49-65 cold inducible RNA binding protein Homo sapiens 41-45
33902703-4 2021 In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils. Uric Acid 49-65 interleukin 1 alpha Homo sapiens 81-89
33902703-4 2021 In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils. Uric Acid 67-70 cold inducible RNA binding protein Homo sapiens 41-45
33902703-4 2021 In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils. Uric Acid 67-70 interleukin 1 alpha Homo sapiens 81-89
33902703-9 2021 However, MSU stimulation induced IL-1beta secretion from CIRP-primed neutrophils in a dose-dependent manner. Uric Acid 9-12 interleukin 1 alpha Homo sapiens 33-41
33902703-9 2021 However, MSU stimulation induced IL-1beta secretion from CIRP-primed neutrophils in a dose-dependent manner. Uric Acid 9-12 cold inducible RNA binding protein Homo sapiens 57-61
33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 interleukin 1 alpha Homo sapiens 17-25
33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 cold inducible RNA binding protein Homo sapiens 41-45
33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 interleukin 1 alpha Homo sapiens 109-117
33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 family with sequence similarity 72 member B Homo sapiens 119-122
33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 NLR family pyrin domain containing 3 Homo sapiens 201-206
33902703-11 2021 Furthermore, cleaved caspase-1 was induced in the cellular lysates of CIRP/MSU-treated neutrophils. Uric Acid 75-78 caspase 1 Homo sapiens 21-30
33902703-11 2021 Furthermore, cleaved caspase-1 was induced in the cellular lysates of CIRP/MSU-treated neutrophils. Uric Acid 75-78 cold inducible RNA binding protein Homo sapiens 70-74
33902703-13 2021 CONCLUSIONS: Our data indicate that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1beta induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. Uric Acid 82-91 cold inducible RNA binding protein Homo sapiens 36-40
33902703-13 2021 CONCLUSIONS: Our data indicate that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1beta induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. Uric Acid 82-91 interleukin 1 alpha Homo sapiens 107-115
33902703-13 2021 CONCLUSIONS: Our data indicate that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1beta induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. Uric Acid 82-91 NLR family pyrin domain containing 3 Homo sapiens 152-157
33902703-14 2021 We propose that CIRP acts as an important proinflammatory stimulant that primes and activates inflammasome and pro-IL-1beta processing in response to uric acid in innate immune cells. Uric Acid 150-159 cold inducible RNA binding protein Homo sapiens 16-20
33902703-14 2021 We propose that CIRP acts as an important proinflammatory stimulant that primes and activates inflammasome and pro-IL-1beta processing in response to uric acid in innate immune cells. Uric Acid 150-159 interleukin 1 beta Homo sapiens 111-123
33460754-7 2021 In addition, AG490 and IL-6 were used in vitro to explore the function of IL-6/STAT3 pathway in the protective effect of MSU. Uric Acid 121-124 interleukin 6 Homo sapiens 74-78
33460754-7 2021 In addition, AG490 and IL-6 were used in vitro to explore the function of IL-6/STAT3 pathway in the protective effect of MSU. Uric Acid 121-124 signal transducer and activator of transcription 3 Homo sapiens 79-84
33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. Uric Acid 84-87 interleukin 1 alpha Homo sapiens 113-121
33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. Uric Acid 84-87 tumor necrosis factor Homo sapiens 123-132
33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. Uric Acid 84-87 interleukin 6 Homo sapiens 138-142
33460754-13 2021 CONCLUSION: Our data indicated that MSW protected rats from MSU-induced experimental gouty arthritis and IL-1beta/IL-6/STAT3 pathway played an essential role in the protective effect of MSU against GA. Uric Acid 186-189 signal transducer and activator of transcription 3 Rattus norvegicus 119-124
33460754-13 2021 CONCLUSION: Our data indicated that MSW protected rats from MSU-induced experimental gouty arthritis and IL-1beta/IL-6/STAT3 pathway played an essential role in the protective effect of MSU against GA. Uric Acid 186-189 interleukin 1 alpha Rattus norvegicus 105-113
33967792-0 2021 beta-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-kappaB Signal Pathway: In Silico and In Vivo. Uric Acid 31-34 NLR family, pyrin domain containing 3 Rattus norvegicus 95-100
33922132-3 2021 Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. Uric Acid 308-317 solute carrier family 5 member 2 Homo sapiens 42-47
33075806-1 2021 CONTEXT: Combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowering. Uric Acid 172-181 solute carrier family 5 member 2 Homo sapiens 21-51
33075806-1 2021 CONTEXT: Combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowering. Uric Acid 172-181 solute carrier family 5 member 2 Homo sapiens 53-58
33075806-1 2021 CONTEXT: Combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowering. Uric Acid 172-181 solute carrier family 22 member 12 Homo sapiens 116-135
33075806-1 2021 CONTEXT: Combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowering. Uric Acid 172-181 solute carrier family 22 member 12 Homo sapiens 137-142
33922132-3 2021 Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. Uric Acid 308-317 solute carrier family 5 member 2 Homo sapiens 10-40
33935726-9 2021 The abundance of the NLRP3 inflammasome and cytokines was significantly increased after RAW264.7 macrophages were treated with MSU (p < 0.01, respectively), while that of miR-223 was significantly reduced (p < 0.01). Uric Acid 127-130 NLR family pyrin domain containing 3 Homo sapiens 21-26
20301530-5 1993 The majority of persons with ADTKD-UMOD have the following laboratory test abnormalities: elevated serum creatinine (decreased estimated glomerular filtration rate), bland urinary sediment, elevated serum urate level, and reduced fractional excretion of uric acid. Uric Acid 205-210 uromodulin Homo sapiens 35-39
33860450-7 2022 The degree of ankle swelling, serum levels of interleukin (IL)-1, and IL-6-related inflammatory factors levels all decreased in the gouty arthritis model established via monosodium urate (MSU) crystals. Uric Acid 170-186 interleukin 6 Rattus norvegicus 70-74
33860450-7 2022 The degree of ankle swelling, serum levels of interleukin (IL)-1, and IL-6-related inflammatory factors levels all decreased in the gouty arthritis model established via monosodium urate (MSU) crystals. Uric Acid 188-191 interleukin 6 Rattus norvegicus 70-74
33618926-0 2021 Age and sex dependent association of uric acid and incident hypertension. Uric Acid 37-46 renin binding protein Homo sapiens 0-3
33618926-2 2021 We aimed to investigate the age and sex dependent association of uric acid (UA) and incident hypertension. Uric Acid 65-74 renin binding protein Homo sapiens 28-31
33618926-2 2021 We aimed to investigate the age and sex dependent association of uric acid (UA) and incident hypertension. Uric Acid 76-78 renin binding protein Homo sapiens 28-31
33618926-10 2021 CONCLUSIONS: The relationship between uric acid and incident hypertension tended to be dependent on age and sex. Uric Acid 38-47 renin binding protein Homo sapiens 100-103
33886461-0 2022 The elevation of serum uric acid depends on insulin resistance but not fasting plasma glucose in hyperuricaemia. Uric Acid 23-32 insulin Homo sapiens 44-51
33996294-2 2021 Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that increases uric acid excretion by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 128-147
33996294-2 2021 Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that increases uric acid excretion by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 149-154
33996294-2 2021 Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that increases uric acid excretion by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 82-91 solute carrier family 22 member 12 Homo sapiens 128-147
33996294-2 2021 Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that increases uric acid excretion by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 82-91 solute carrier family 22 member 12 Homo sapiens 149-154
20301530-5 1993 The majority of persons with ADTKD-UMOD have the following laboratory test abnormalities: elevated serum creatinine (decreased estimated glomerular filtration rate), bland urinary sediment, elevated serum urate level, and reduced fractional excretion of uric acid. Uric Acid 254-263 uromodulin Homo sapiens 35-39
32810934-0 2021 Chicken serum uric acid level is regulated by glucose transporter 9. Uric Acid 14-23 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 46-67
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 96-112 caspase 1 Homo sapiens 14-23
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 96-112 interleukin 1 alpha Mus musculus 39-47
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 96-112 NLR family pyrin domain containing 3 Homo sapiens 62-67
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 114-117 caspase 1 Homo sapiens 14-23
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 114-117 interleukin 1 alpha Mus musculus 39-47
33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 114-117 NLR family pyrin domain containing 3 Homo sapiens 62-67
33359866-11 2021 CONCLUSION: Lychnopholide, eremantholide C, and goyazensolide improved the inflammation induced by MSU crystals by inhibiting the migration of neutrophils to the inflamed area and by blocking the release of the pro-inflammatory cytokine TNF-alpha. Uric Acid 99-102 tumor necrosis factor Mus musculus 237-246
32810934-1 2021 Objective: Glucose transporter 9 (GLUT9) is a uric acid transporter that associated with uric absorption in mice and human; but it is unknown whether GLUT9 involves in chicken uric acid regulation. Uric Acid 46-55 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 11-32
32810934-1 2021 Objective: Glucose transporter 9 (GLUT9) is a uric acid transporter that associated with uric absorption in mice and human; but it is unknown whether GLUT9 involves in chicken uric acid regulation. Uric Acid 46-55 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 34-39
33706058-1 2021 OBJECTIVE: To determine the value of uric acid (UA) as a prognostic biomarker for amyotrophic lateral sclerosis (ALS) using a meta-analysis of hazard ratio-based studies. Uric Acid 37-46 superoxide dismutase 1 Homo sapiens 113-116
33617845-4 2021 We concluded from a comparison of E3S and uric acid transport that SLC22A11 does not translocate E3S into the cytosol, but into the plasma membrane. Uric Acid 42-51 solute carrier family 22 member 11 Homo sapiens 67-75
32901127-8 2021 The depletion of RKIP aggravated inflammasome-related diseases such as monosodium urate (MSU)-induced gouty arthritis and high-fat diet (HFD)-induced metabolic disorders. Uric Acid 71-87 phosphatidylethanolamine binding protein 1 Homo sapiens 17-21
32901127-8 2021 The depletion of RKIP aggravated inflammasome-related diseases such as monosodium urate (MSU)-induced gouty arthritis and high-fat diet (HFD)-induced metabolic disorders. Uric Acid 89-92 phosphatidylethanolamine binding protein 1 Homo sapiens 17-21
33706058-13 2021 CONCLUSION: The present meta-analysis suggests that the serum UA level could be a prognostic biomarker in patients with ALS. Uric Acid 62-64 superoxide dismutase 1 Homo sapiens 120-123
33869182-15 2021 The study demonstrated that triiodothyronine is independently positively correlated with serum urate and liver uric acid production through Period2, providing novel insights into the purine metabolism underlying hyperuricemia/gout pathophysiology. Uric Acid 111-120 period circadian clock 2 Mus musculus 140-147
32875512-8 2021 Additionally, plasma IL-1beta and IL-9 levels were increased along with those of blood uric acid (R2 = 0.4116 and R2 = 0.4150, respectively, P < 0.001). Uric Acid 87-96 interleukin 1 alpha Homo sapiens 21-29
32875512-8 2021 Additionally, plasma IL-1beta and IL-9 levels were increased along with those of blood uric acid (R2 = 0.4116 and R2 = 0.4150, respectively, P < 0.001). Uric Acid 87-96 interleukin 9 Homo sapiens 34-38
33869182-0 2021 Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production. Uric Acid 63-68 period circadian regulator 2 Homo sapiens 40-47
33601190-1 2021 INTRODUCTION: Pegloticase is a recombinant PEGylated uricase that converts relatively insoluble urate to highly water-soluble allantoin, which is readily excreted by the kidneys. Uric Acid 96-101 urate oxidase (pseudogene) Homo sapiens 53-60
33517224-0 2021 Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation. Uric Acid 35-38 cathepsin B Mus musculus 86-97
33517224-0 2021 Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation. Uric Acid 35-38 NLR family, pyrin domain containing 3 Mus musculus 107-112
32683776-10 2021 We found that individuals in the highest category of SSB intake had 0.18 mg dL-1 greater concentrations of serum uric acid compared to those in the lowest category (summary effect size: 0.18 mg dL-1 ; 95% confidence interval = 0.11-0.25). Uric Acid 113-122 l(1)L1 Drosophila melanogaster 76-80
33407049-1 2021 We investigated the impact of estrogen receptor (ER) expression in renal tubular epithelial cells on serum uric acid (UA) levels in premenopausal patients with systemic lupus erythematosus (SLE). Uric Acid 107-116 estrogen receptor 1 Homo sapiens 30-47
33407049-1 2021 We investigated the impact of estrogen receptor (ER) expression in renal tubular epithelial cells on serum uric acid (UA) levels in premenopausal patients with systemic lupus erythematosus (SLE). Uric Acid 107-116 estrogen receptor 1 Homo sapiens 49-51
33407049-10 2021 These findings suggest that the expression of ERbeta in premenopausal female SLE patients may cause hyperuricemia, and may subsequently promote glomerular damage, suggesting that ERbeta may be involved in UA excretion. Uric Acid 205-207 estrogen receptor 1 Homo sapiens 46-52
33407049-10 2021 These findings suggest that the expression of ERbeta in premenopausal female SLE patients may cause hyperuricemia, and may subsequently promote glomerular damage, suggesting that ERbeta may be involved in UA excretion. Uric Acid 205-207 estrogen receptor 1 Homo sapiens 179-185
33218916-0 2021 Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes. Uric Acid 6-15 insulin Homo sapiens 49-56
33854690-6 2021 In the human body, xanthine oxidoreductase (XOR) catalyzes the oxidative hydroxylation of hypoxanthine to xanthine to uric acid, with the accompanying production of ROS. Uric Acid 118-127 xanthine dehydrogenase Homo sapiens 19-42
33854503-4 2021 Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation. Uric Acid 258-274 caspase 1 Mus musculus 138-147
33854503-4 2021 Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation. Uric Acid 258-274 NLR family, pyrin domain containing 3 Mus musculus 206-211
33854503-4 2021 Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation. Uric Acid 276-279 caspase 1 Mus musculus 138-147
33854503-4 2021 Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation. Uric Acid 276-279 NLR family, pyrin domain containing 3 Mus musculus 206-211
33994037-8 2022 Regarding analytical parameters, Ucn-2 correlated positively with log BNP (r = 0.22, P = 0.055) and inversely with uric acid (r = 0.24, P = 0.029) and total (r = -0.30, P = 0.007) and low-density lipoprotein cholesterol (r = -0.23, P = 0.038). Uric Acid 115-124 urocortin 2 Homo sapiens 33-38
33854690-6 2021 In the human body, xanthine oxidoreductase (XOR) catalyzes the oxidative hydroxylation of hypoxanthine to xanthine to uric acid, with the accompanying production of ROS. Uric Acid 118-127 xanthine dehydrogenase Homo sapiens 44-47
33994251-13 2021 Moreover, hyperuricemia-induced secretions of proinflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and monocyte chemoattractant protein-1(MCP-1) in HN mice and uric acid-stimulated TCMK-1 cells were mitigated by fisetin treatment. Uric Acid 203-212 chemokine (C-C motif) ligand 2 Mus musculus 181-186
33648977-3 2021 In comparison to wild-type (WT) rats, serum urate levels spontaneously and persistently increased in UOX-KO rats without a significant decrease in survival rate. Uric Acid 44-49 urate oxidase Rattus norvegicus 101-104
33663556-9 2021 RESULTS: Adherence to dietary recommendations, BMI (< 25 kg/m2), and absence of the SLC2A9 rs12498742 urate-raising allele produced PAFs for HU of 20 to 24%, 59 to 69%, and 57 to 64%, respectively, in the three non-gout cohorts. Uric Acid 102-107 solute carrier family 2 member 9 Homo sapiens 84-90
33741037-6 2021 RESULTS: Synovial fluid CD14+ macrophages significantly engulfed the MSU crystal-induced NETs, as evidenced by the alteration in SYTOX Green intensity or the presence of NE and MPO in the cytoplasm of CD14+ cells. Uric Acid 69-72 CD14 molecule Homo sapiens 24-28
33741037-6 2021 RESULTS: Synovial fluid CD14+ macrophages significantly engulfed the MSU crystal-induced NETs, as evidenced by the alteration in SYTOX Green intensity or the presence of NE and MPO in the cytoplasm of CD14+ cells. Uric Acid 69-72 elastase, neutrophil expressed Homo sapiens 89-91
33704056-10 2021 There was also a significant correlation between serum endocan level and uric acid level in the study group (r = 0.325, p = 0.028). Uric Acid 73-82 endothelial cell specific molecule 1 Homo sapiens 55-62
33728547-1 2021 Verinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Uric Acid 13-22 solute carrier family 22 member 12 Homo sapiens 38-43
33721849-2 2021 It was expected that the resulting glassy carbon electrodes modified by 1D CNTs@NPC (CNTs@NPC/GCE) could express different electrochemical responses to ascorbic acid (AA), dopamine (DA), uric acid (UA), by virtue of the synergistic-improved effect between CNTs and NPC. Uric Acid 187-196 aminomethyltransferase Homo sapiens 85-97
33721849-2 2021 It was expected that the resulting glassy carbon electrodes modified by 1D CNTs@NPC (CNTs@NPC/GCE) could express different electrochemical responses to ascorbic acid (AA), dopamine (DA), uric acid (UA), by virtue of the synergistic-improved effect between CNTs and NPC. Uric Acid 198-200 aminomethyltransferase Homo sapiens 85-97
33721849-3 2021 Under the optimized conditions, there were excellent analytical parameters for CNTs@NPC/GCE to detect AA, DA and UA, i.e., a wide linear range of 40~2100 muM for AA, 0.5~49 muM for DA and 3~50 muM for AA with low detection limits of 0.36 muM, 0.02 mumol/L and 0.57 muM respectively. Uric Acid 113-115 aminomethyltransferase Homo sapiens 79-91
33721849-4 2021 Importantly, the proposed CNTs@NPC/GCE was efficiently applied to determine AA, DA and UA in some real samples with high stability, reproducibility and selectivity. Uric Acid 87-89 aminomethyltransferase Homo sapiens 26-38
33746978-0 2021 Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture. Uric Acid 26-42 Dcr3 Mus musculus 0-16
33746978-0 2021 Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture. Uric Acid 26-42 NLR family, pyrin domain containing 3 Mus musculus 51-56
33746978-10 2021 These findings indicate that HBD of DcR3 can reduce MSU crystal-induced NLRP3 inflammasome activation via modulation of mitochondrial and lysosomal functions. Uric Acid 52-55 Dcr3 Mus musculus 36-40
33746978-10 2021 These findings indicate that HBD of DcR3 can reduce MSU crystal-induced NLRP3 inflammasome activation via modulation of mitochondrial and lysosomal functions. Uric Acid 52-55 NLR family, pyrin domain containing 3 Mus musculus 72-77
33746978-5 2021 In this study, we clarified the actions of DcR3 and its non-decoy action motif heparin sulfate proteoglycan (HSPG) binding domain (HBD) in the MSU crystal-induced NLRP3 inflammasome activation in the macrophages and in mice. Uric Acid 143-146 Dcr3 Mus musculus 43-47
33746978-5 2021 In this study, we clarified the actions of DcR3 and its non-decoy action motif heparin sulfate proteoglycan (HSPG) binding domain (HBD) in the MSU crystal-induced NLRP3 inflammasome activation in the macrophages and in mice. Uric Acid 143-146 exocyst complex component 6 Mus musculus 131-134
33746978-5 2021 In this study, we clarified the actions of DcR3 and its non-decoy action motif heparin sulfate proteoglycan (HSPG) binding domain (HBD) in the MSU crystal-induced NLRP3 inflammasome activation in the macrophages and in mice. Uric Acid 143-146 NLR family, pyrin domain containing 3 Mus musculus 163-168
33746978-6 2021 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid 76-79 interleukin 1 alpha Homo sapiens 109-117
33746978-6 2021 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid 76-79 NLR family pyrin domain containing 3 Homo sapiens 136-141
33746978-6 2021 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid 76-79 TNF receptor superfamily member 6b Homo sapiens 166-170
33746978-6 2021 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid 76-79 exocyst complex component 6 Mus musculus 178-181
33746978-7 2021 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid 23-26 NLR family pyrin domain containing 3 Homo sapiens 35-40
33746978-7 2021 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid 23-26 cathepsin B Mus musculus 225-236
33746978-7 2021 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid 23-26 NLR family pyrin domain containing 3 Homo sapiens 297-302
33746978-8 2021 In the air pouch mice model of gout, MSU induced less amounts of IL-1beta and chemokines secretion, an increased M2/M1 macrophage ratio, and a reduction of neutrophil recruitment in DcR3-transgenic mice, which expresses DcR3 in myeloid cells. Uric Acid 37-40 interleukin 1 alpha Mus musculus 65-73
33746978-8 2021 In the air pouch mice model of gout, MSU induced less amounts of IL-1beta and chemokines secretion, an increased M2/M1 macrophage ratio, and a reduction of neutrophil recruitment in DcR3-transgenic mice, which expresses DcR3 in myeloid cells. Uric Acid 37-40 Dcr3 Mus musculus 182-186
33746978-8 2021 In the air pouch mice model of gout, MSU induced less amounts of IL-1beta and chemokines secretion, an increased M2/M1 macrophage ratio, and a reduction of neutrophil recruitment in DcR3-transgenic mice, which expresses DcR3 in myeloid cells. Uric Acid 37-40 Dcr3 Mus musculus 220-224
33746978-10 2021 These findings indicate that HBD of DcR3 can reduce MSU crystal-induced NLRP3 inflammasome activation via modulation of mitochondrial and lysosomal functions. Uric Acid 52-55 exocyst complex component 6 Mus musculus 29-32
32979053-6 2021 Since ABCG2 is present in all major biological barriers and drug-metabolizing organs, influences the pharmacokinetics of numerous clinically applied drugs, and plays a key role in uric acid extrusion, this information may significantly promote a reliable prediction of clinically important substrate characteristics and drug-drug interactions. Uric Acid 180-189 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 6-11
33058037-14 2021 In multivariate linear regression analysis (variables: MBP, urea, creatinine, eGFR, ferritin, uric acid, CA-IMT) azurocidin was independently associated with urea (t:2.658; p = 0.010) and CA-IMT (t:2.464; p = 0.017). Uric Acid 94-103 azurocidin 1 Homo sapiens 113-123
33454278-10 2021 Lean mass index (LMI) and uric acid levels mediated the relationship between DII and S-Klotho plasma levels. Uric Acid 26-35 klotho Homo sapiens 87-93
33454278-11 2021 CONCLUSION: A pro-inflammatory dietary pattern was inversely associated with S-Klotho plasma levels in young adults, which was partially mediated by LMI and uric acid levels. Uric Acid 157-166 klotho Homo sapiens 79-85
33833974-10 2021 Conclusion: Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels. Uric Acid 188-197 vitrin Homo sapiens 12-15
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 NLR family pyrin domain containing 3 Homo sapiens 0-5
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 atrophin 1 Homo sapiens 7-10
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 PYD and CARD domain containing Homo sapiens 120-154
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 PYD and CARD domain containing Homo sapiens 156-159
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 caspase 1 Homo sapiens 195-224
33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 NLR family pyrin domain containing 3 Homo sapiens 243-248
33508700-0 2021 Serum uric acid level as a putative biomarker in Parkinson"s disease patients carrying GBA1 mutations: 2-Year data from the PPMI study. Uric Acid 6-15 glucosylceramidase beta Homo sapiens 87-91
33508700-3 2021 The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocerebrosidase (GBA1) gene, sporadic PD, and healthy controls followed longitudinally. Uric Acid 66-75 glucosylceramidase beta Homo sapiens 147-151
33508700-6 2021 RESULTS: Following adjustment for age, sex and BMI the GBA-PD cohort exhibited lower 2-year longitudinal uric acid level as compared to the controls (p = 0.016). Uric Acid 105-114 glucosylceramidase beta Homo sapiens 55-58
33508700-7 2021 Baseline uric acid measurements showed only a marginal difference (p = 0.119), but year 2 uric acid levels were lower in the GBA-PD cohort (p < 0.001). Uric Acid 90-99 glucosylceramidase beta Homo sapiens 125-128
33508700-9 2021 CONCLUSIONS: This is the first study to assess serum uric acid in a GBA-PD cohort. Uric Acid 53-62 glucosylceramidase beta Homo sapiens 68-71
33508700-10 2021 Our findings suggest that low serum uric acid might be a progression biomarker in GBA-PD. Uric Acid 36-45 glucosylceramidase beta Homo sapiens 82-85
33508700-11 2021 However, more studies (ideally longitudinal) on the association between low serum uric acid and clinical data in GBA-PD are needed. Uric Acid 82-91 glucosylceramidase beta Homo sapiens 113-116
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 48-53 solute carrier family 2 member 9 Homo sapiens 0-21
33427846-3 2021 Herein, beta-phase anhydrous guanine (beta-AG) microrods were formed in mixed solvents of formamide and water in the presence of small organic molecules such as uric acid, pyrrole (Py), N-methyl-2-pyrrolidone (NMP), N-vinyl-2-pyrrolidone (NVP). Uric Acid 161-170 N-methylpurine DNA glycosylase Homo sapiens 38-45
33669298-5 2021 Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (beta = 0.26, p < 0.001), diabetes (beta = 0.09, p < 0.001), dyslipidemia (beta = 0.08, p = 0.001), and uric acid (beta = 0.13, p < 0.001). Uric Acid 214-223 xanthine dehydrogenase Homo sapiens 47-50
33429196-0 2021 Uric acid inhibits HMGB1-TLR4-NF-kappaB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia. Uric Acid 0-9 high mobility group box 1 Mus musculus 19-24
33429196-0 2021 Uric acid inhibits HMGB1-TLR4-NF-kappaB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia. Uric Acid 0-9 toll-like receptor 4 Mus musculus 25-29
33429196-0 2021 Uric acid inhibits HMGB1-TLR4-NF-kappaB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia. Uric Acid 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 30-39
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 tumor necrosis factor Mus musculus 72-81
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 interleukin 1 alpha Mus musculus 83-90
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 interleukin 6 Mus musculus 96-99
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 high mobility group box 1 Mus musculus 142-147
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 toll-like receptor 4 Mus musculus 148-152
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 9-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 153-162
33643024-13 2021 Meanwhile, our findings indicated that women with high GGT levels had an increased risk of MCI when they were obese, sleep deprived, had high serum uric acid (SUA) levels or underwent menopause. Uric Acid 148-157 gamma-glutamyltransferase 1 Homo sapiens 55-58
33865236-8 2021 Excretion of ammonia in the urine and urine pH levels increased after treatment of DKA, which resulted in the formation of AAU crystals. Uric Acid 123-126 phenylalanine hydroxylase Homo sapiens 44-46
33627489-7 2021 Retrospective study of 247 patients who were diagnosed with kidney damage receiving cyclosporine or cisplatin in combination with the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin showed significant (P < 0.001) improvement of kidney function, as well as reduction in creatinine and uric acid, markers of kidney damage. Uric Acid 299-308 solute carrier family 5 member 2 Homo sapiens 134-164
33627489-7 2021 Retrospective study of 247 patients who were diagnosed with kidney damage receiving cyclosporine or cisplatin in combination with the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin showed significant (P < 0.001) improvement of kidney function, as well as reduction in creatinine and uric acid, markers of kidney damage. Uric Acid 299-308 solute carrier family 5 member 2 Homo sapiens 166-171
33618649-10 2021 The correlation coefficient value of uric acid (r = 0.295, p < 0.008) with BCR-ABL showed that weak correlation which exists between the two test parameter. Uric Acid 37-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 75-82
33618649-14 2021 CONCLUSION AND RECOMMENDATION: The CML LDH value strongly correlated with BCR-ABL transcript level, whereas uric acid was weakly correlated with BCR-ABL. Uric Acid 108-117 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 145-152
33664670-7 2021 Although there were increased serum levels of uric acid and xanthine oxidase, an enzyme that catalyzes production of uric acid, and decreased expression of renal organic anion transporter 1 and 3 that promote urate excretion in the model of HN, and reduced expression levels of urine uric acid, I-BET151 treatment did not affect these responses. Uric Acid 209-214 solute carrier family 22 member 6 Rattus norvegicus 156-195
33429196-9 2021 Finally, uric acid reduced the release of the proinflammatory cytokines TNF-alpha, IL1beta, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-kappaB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Uric Acid 238-247 high mobility group box 1 Mus musculus 142-147
33429196-10 2021 Hence, uric acid halted the release of inflammatory factors and the decreased cell viability induced by ODG/R via inhibiting the microglia HMGB1-TLR4-NF-kappaB signaling, thereby alleviating the damage to microglia. Uric Acid 7-16 high mobility group box 1 Mus musculus 139-144
33429196-10 2021 Hence, uric acid halted the release of inflammatory factors and the decreased cell viability induced by ODG/R via inhibiting the microglia HMGB1-TLR4-NF-kappaB signaling, thereby alleviating the damage to microglia. Uric Acid 7-16 toll-like receptor 4 Mus musculus 145-149
33429196-10 2021 Hence, uric acid halted the release of inflammatory factors and the decreased cell viability induced by ODG/R via inhibiting the microglia HMGB1-TLR4-NF-kappaB signaling, thereby alleviating the damage to microglia. Uric Acid 7-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 150-159
33580173-1 2021 Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. Uric Acid 102-111 xanthine dehydrogenase Homo sapiens 0-23
33580173-1 2021 Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of xanthine to uric acid. Uric Acid 102-111 xanthine dehydrogenase Homo sapiens 25-28
33634117-3 2021 The xanthine oxidase (XO) form of xanthine oxidoreductase (XOR), the key enzyme in xanthine and uric acid metabolism, is a major cellular source of superoxide. Uric Acid 96-105 xanthine dehydrogenase Mus musculus 4-20
33634117-3 2021 The xanthine oxidase (XO) form of xanthine oxidoreductase (XOR), the key enzyme in xanthine and uric acid metabolism, is a major cellular source of superoxide. Uric Acid 96-105 xanthine dehydrogenase Mus musculus 34-57
33634117-3 2021 The xanthine oxidase (XO) form of xanthine oxidoreductase (XOR), the key enzyme in xanthine and uric acid metabolism, is a major cellular source of superoxide. Uric Acid 96-105 xanthine dehydrogenase Mus musculus 59-62
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 48-53 solute carrier family 2 member 9 Homo sapiens 23-28
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 162-171 solute carrier family 2 member 9 Homo sapiens 0-21
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 162-171 solute carrier family 2 member 9 Homo sapiens 23-28
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 172-177 solute carrier family 2 member 9 Homo sapiens 0-21
32844721-1 2021 Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. Uric Acid 172-177 solute carrier family 2 member 9 Homo sapiens 23-28
33356297-4 2021 11 changed metabolites were found in MRL/lpr mice at 9 weeks of age, which were mainly involved in the tricarboxylic acid (TCA) cycle, glycolysis, and butanoate metabolism; with the increase of week age, the TCA cycle was still disturbed, and the biosynthesis of fatty acids was significantly upregulated since 11 weeks of age; in addition, urea, urate, and indole-3-lactate were increased at 13 weeks of age. Uric Acid 347-352 Fas (TNF receptor superfamily member 6) Mus musculus 41-44
33086215-5 2021 Gold nanoparticles at N-doped bovine serum albumin carbon (AuNPs@NBSAC)-modified three-electrode strip-based flexible sensor system has been developed, which displayed effective, sensitive and selective for simultaneous detection of uric acid (UA) and dopamine (DA). Uric Acid 233-242 albumin Homo sapiens 37-50
33086215-5 2021 Gold nanoparticles at N-doped bovine serum albumin carbon (AuNPs@NBSAC)-modified three-electrode strip-based flexible sensor system has been developed, which displayed effective, sensitive and selective for simultaneous detection of uric acid (UA) and dopamine (DA). Uric Acid 244-246 albumin Homo sapiens 37-50
33547278-0 2021 Sensing soluble uric acid by Naip1-Nlrp3 platform. Uric Acid 16-25 NLR family, apoptosis inhibitory protein 1 Mus musculus 29-34
33547278-0 2021 Sensing soluble uric acid by Naip1-Nlrp3 platform. Uric Acid 16-25 NLR family pyrin domain containing 3 Homo sapiens 35-40
33547278-1 2021 Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 164-171
33547278-1 2021 Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Uric Acid 11-13 urate oxidase (pseudogene) Homo sapiens 164-171
33547278-2 2021 Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1beta (IL-1beta) in murine macrophages. Uric Acid 36-38 interleukin 1 beta Homo sapiens 91-108
33547278-2 2021 Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1beta (IL-1beta) in murine macrophages. Uric Acid 36-38 interleukin 1 alpha Homo sapiens 110-118
33487257-3 2021 Furthermore, the association between uric acid levels and insulin resistance indexes was assessed. Uric Acid 37-46 insulin Homo sapiens 58-65
33639683-2 2021 Urate oxidase (UOX) that catalyzes the enzymatic oxidation of uric acid into allantoin, is effective in lowering plasma uric acid levels and controlling hyperuricemia. Uric Acid 62-71 urate oxidase Rattus norvegicus 15-18
33639683-2 2021 Urate oxidase (UOX) that catalyzes the enzymatic oxidation of uric acid into allantoin, is effective in lowering plasma uric acid levels and controlling hyperuricemia. Uric Acid 120-129 urate oxidase Rattus norvegicus 15-18
33639683-13 2021 In summary, the results indicated that PASylated UOX drug is effective at lowering plasma uric acid levels with prolonged plasma half-life and decreased cost.
. Uric Acid 90-99 urate oxidase Rattus norvegicus 49-52
33467979-6 2021 LncRNA HOTAIR and Nlrp3 expression was upregulated, and that of miR-20b was downregulated in synovial fluid mononuclear cells (SFMCs) collected from patients with gouty arthritis and monosodium urate (MSU)-stimulated THP-1 cells. Uric Acid 183-199 microRNA 20b Homo sapiens 64-71
33467979-8 2021 The methylation percentage of HOTAIR was reduced in SFMCs from patients with gouty arthritis and MSU-stimulated THP-1 cells. Uric Acid 97-100 HOX transcript antisense RNA Homo sapiens 30-36
33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 58-65
33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 120-127
33448693-1 2021 Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Uric Acid 76-85 xanthine dehydrogenase Mus musculus 0-23
33448693-1 2021 Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Uric Acid 76-85 xanthine dehydrogenase Mus musculus 25-28
33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 120-127
33487257-11 2021 CONCLUSION: Probiotic yogurt consumption through improvement in insulin sensitivity may exert positive effects on the oxidative stress and uric acid levels. Uric Acid 139-148 insulin Homo sapiens 64-71
33535693-8 2021 In severe OSA patients, there was a positive correlation between LOX-1 levels and uric acid. Uric Acid 82-91 oxidized low density lipoprotein receptor 1 Homo sapiens 65-70
33400348-2 2021 Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects. Uric Acid 55-64 xanthine dehydrogenase Homo sapiens 0-23
32778763-0 2021 Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Uric Acid 30-35 solute carrier family 2 member 9 Homo sapiens 68-74
32778763-0 2021 Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Uric Acid 30-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 79-84
32778763-3 2021 SLC2A9 and ABCG2 are major loci associated with both urate and gout in multiple ancestral groups. Uric Acid 53-58 solute carrier family 2 member 9 Homo sapiens 0-6
32778763-3 2021 SLC2A9 and ABCG2 are major loci associated with both urate and gout in multiple ancestral groups. Uric Acid 53-58 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 11-16
32778763-6 2021 Trans-ancestral meta-analyses of GWAS cohorts of either European (EUR) or East Asian (EAS) ancestry resulted in single-variant resolution mappings for SLC2A9 (rs3775948 for urate and rs4697701 for gout) and ABCG2 (rs2622621 for gout). Uric Acid 173-178 solute carrier family 2 member 9 Homo sapiens 151-157
32778763-7 2021 Tests of colocalization of variants in both urate and gout suggested existence of a shared candidate causal variant for SLC2A9 only in EUR and for ABCG2 only in EAS. Uric Acid 44-49 solute carrier family 2 member 9 Homo sapiens 120-126
32778763-9 2021 Additional primate-specific elements were found near both loci and those adjacent to SLC2A9 overlapped with known statistical epistatic interactions associated with urate as well as multiple super-enhancers identified in urate-relevant tissues. Uric Acid 165-170 solute carrier family 2 member 9 Homo sapiens 85-91
32778763-9 2021 Additional primate-specific elements were found near both loci and those adjacent to SLC2A9 overlapped with known statistical epistatic interactions associated with urate as well as multiple super-enhancers identified in urate-relevant tissues. Uric Acid 221-226 solute carrier family 2 member 9 Homo sapiens 85-91
32778763-10 2021 We conclude that by leveraging ancestral differences trans-ancestral fine mapping has identified ancestral and functional variants for SLC2A9 or ABCG2 with primate-specific regulatory effects on urate and gout. Uric Acid 195-200 solute carrier family 2 member 9 Homo sapiens 135-141
32778763-10 2021 We conclude that by leveraging ancestral differences trans-ancestral fine mapping has identified ancestral and functional variants for SLC2A9 or ABCG2 with primate-specific regulatory effects on urate and gout. Uric Acid 195-200 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 145-150
32901114-0 2021 Correction to: Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Uric Acid 45-50 solute carrier family 2 member 9 Homo sapiens 83-89
32901114-0 2021 Correction to: Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Uric Acid 45-50 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 94-99
33239408-0 2021 Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1beta Production. Uric Acid 97-113 interleukin 1 alpha Homo sapiens 130-138
33239408-2 2021 Phagocytic uptake of MSU crystals by joint-resident macrophages and recruited circulating monocytes results in IL-1beta expression and production. Uric Acid 21-24 interleukin 1 alpha Homo sapiens 111-119
33239408-5 2021 We hypothesized that innate immune danger signals e.g. lipopolysaccharide (LPS) and soluble uric acid (sUA) prime human monocytes towards MSU crystal phagocytosis, and increased IL-1beta production mediated by a reduction in PP2A activity and restoring PP2A activity exerts an anti-inflammatory effect in this setting. Uric Acid 92-101 interleukin 1 alpha Homo sapiens 178-186
33239408-5 2021 We hypothesized that innate immune danger signals e.g. lipopolysaccharide (LPS) and soluble uric acid (sUA) prime human monocytes towards MSU crystal phagocytosis, and increased IL-1beta production mediated by a reduction in PP2A activity and restoring PP2A activity exerts an anti-inflammatory effect in this setting. Uric Acid 92-101 protein phosphatase 2 phosphatase activator Homo sapiens 225-229
33239408-5 2021 We hypothesized that innate immune danger signals e.g. lipopolysaccharide (LPS) and soluble uric acid (sUA) prime human monocytes towards MSU crystal phagocytosis, and increased IL-1beta production mediated by a reduction in PP2A activity and restoring PP2A activity exerts an anti-inflammatory effect in this setting. Uric Acid 92-101 protein phosphatase 2 phosphatase activator Homo sapiens 253-257
33239408-7 2021 A combination of LPS + sUA priming and MSU crystals reduced PP2A activity in monocytes by 60% (p=0.013). Uric Acid 39-42 protein phosphatase 2 phosphatase activator Homo sapiens 60-64
33239408-8 2021 PP2A catalytic subunit gene knockdown reduced PP2A activity and exacerbated MSU crystal induced IL-1beta expression and secretion (p<0.0001). Uric Acid 76-79 protein phosphatase 2 phosphatase activator Homo sapiens 0-4
33239408-8 2021 PP2A catalytic subunit gene knockdown reduced PP2A activity and exacerbated MSU crystal induced IL-1beta expression and secretion (p<0.0001). Uric Acid 76-79 interleukin 1 alpha Homo sapiens 96-104
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 192-201 protein phosphatase 2 phosphatase activator Homo sapiens 47-61
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 192-201 protein phosphatase 2 phosphatase activator Homo sapiens 63-67
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 192-201 interleukin 1 alpha Homo sapiens 128-136
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 242-270 protein phosphatase 2 phosphatase activator Homo sapiens 47-61
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 242-270 protein phosphatase 2 phosphatase activator Homo sapiens 63-67
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 242-270 interleukin 1 alpha Homo sapiens 128-136
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 272-275 protein phosphatase 2 phosphatase activator Homo sapiens 47-61
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 272-275 protein phosphatase 2 phosphatase activator Homo sapiens 63-67
33239408-11 2021 Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals. Uric Acid 272-275 interleukin 1 alpha Homo sapiens 128-136
33615201-5 2021 In addition, Treg-of-B cells inhibited monosodium urate-induced NLRP3 inflammasome activation in vitro via NF-kappaB signaling. Uric Acid 39-55 NLR family, pyrin domain containing 3 Mus musculus 64-69
32767109-1 2021 INTRODUCTION: This cross-sectional study investigates the association between insulin resistance (IR) and serum uric acid (sUA) and relative fat (RFM) and lean mass (RLM) profiles in children with chronic kidney disease (CKD). Uric Acid 112-121 insulin Homo sapiens 78-85
33515125-0 2021 Modulations of Nav1.8 and Nav1.9 Channels in Monosodium Urate-Induced Gouty Arthritis in Mice. Uric Acid 45-61 sodium channel, voltage-gated, type X, alpha Mus musculus 15-21
33515125-0 2021 Modulations of Nav1.8 and Nav1.9 Channels in Monosodium Urate-Induced Gouty Arthritis in Mice. Uric Acid 45-61 sodium channel, voltage-gated, type XI, alpha Mus musculus 26-32
33515125-1 2021 The aim of the present study was to observe the changes of TTX-R, Nav1.8, and Nav1.9 Na+ currents in MSU-induced gouty arthritis mice, and to explore the possibility of Nav1.8 and Nav1.9 channels as potential targets for gout pain treatment. Uric Acid 101-104 sodium channel, voltage-gated, type XI, alpha Mus musculus 78-84
33515125-8 2021 For TTX-R Na+ channel subunits, Nav1.8 current density was significantly increased, but Nav1.9 current density was markedly decreased after MSU treatment. Uric Acid 140-143 sodium channel, voltage-gated, type XI, alpha Mus musculus 88-94
33514836-4 2021 Inducible NO synthase (iNOS) inhibition by dexamethasone promoted an increase in the survival rate of P. berghei-infected mice, and the data suggested the participation of oxidative stress in the brain as a result of plasmodial infection, as well as the inhibition of brain NO synthesis, which promoted the survival rate of almost 90% of the animals until the 15th day of infection, with possible direct interference of ischemia and reperfusion syndrome, as seen by increased levels of uric acid. Uric Acid 486-495 nitric oxide synthase 2, inducible Mus musculus 23-27
33515125-9 2021 MSU treatment shifted the steady-state activation curves of TTX-R Na+ channel, Nav1.8 and Nav1.9 channels, and the inactivation curves of TTX-R Na+ channel and Nav1.8 channels to the depolarizing direction, but did not affect the inactivation curve of Nav1.9 channel. Uric Acid 0-3 sodium channel, voltage-gated, type X, alpha Mus musculus 79-85
33515125-9 2021 MSU treatment shifted the steady-state activation curves of TTX-R Na+ channel, Nav1.8 and Nav1.9 channels, and the inactivation curves of TTX-R Na+ channel and Nav1.8 channels to the depolarizing direction, but did not affect the inactivation curve of Nav1.9 channel. Uric Acid 0-3 sodium channel, voltage-gated, type XI, alpha Mus musculus 90-96
33515125-9 2021 MSU treatment shifted the steady-state activation curves of TTX-R Na+ channel, Nav1.8 and Nav1.9 channels, and the inactivation curves of TTX-R Na+ channel and Nav1.8 channels to the depolarizing direction, but did not affect the inactivation curve of Nav1.9 channel. Uric Acid 0-3 sodium channel, voltage-gated, type X, alpha Mus musculus 160-166
33515125-9 2021 MSU treatment shifted the steady-state activation curves of TTX-R Na+ channel, Nav1.8 and Nav1.9 channels, and the inactivation curves of TTX-R Na+ channel and Nav1.8 channels to the depolarizing direction, but did not affect the inactivation curve of Nav1.9 channel. Uric Acid 0-3 sodium channel, voltage-gated, type XI, alpha Mus musculus 252-258
33515125-13 2021 Nav1.8 channel, not Nav1.9 channel, may be involved in MSU-induced gout pain by increasing nerve excitability. Uric Acid 55-58 sodium channel, voltage-gated, type X, alpha Mus musculus 0-6
33461598-13 2021 Importantly, the binding is strengthened with LPS or alpha-syn overexpression but alleviated by urate, a potential clinical biomarker for PD. Uric Acid 96-101 synuclein, alpha Mus musculus 53-62
33551217-6 2021 RESULTS: HiFruD increased fasting uric acid (p < 0.05) and reduced fasting insulin sensitivity estimated by the homeostasis model assessment (HOMA) for insulin resistance (p < 0.05), in both groups. Uric Acid 34-43 insulin Homo sapiens 152-159
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 tumor necrosis factor Rattus norvegicus 48-75
33127482-0 2021 High uric acid promotes dysfunction in pancreatic beta cells by blocking IRS2/AKT signallingsignalling. Uric Acid 5-14 insulin receptor substrate 2 Rattus norvegicus 73-77
32896590-9 2021 RESULTS: MMP-3 was significantly increased in rat serum, synovial fluid, cartilages and chondrocytes treated with high-level uric acid. Uric Acid 125-134 matrix metallopeptidase 3 Homo sapiens 9-14
32896590-11 2021 Furthermore, high-level uric acid contributed to the degradation of proteoglycan via the activation of MMP-3. Uric Acid 24-33 matrix metallopeptidase 3 Homo sapiens 103-108
32896590-12 2021 IL-6, IL-1beta and TNF-alpha concentrations were increased significantly in 35 C compared to 37 C with MMP-3 and high-level uric acid. Uric Acid 126-135 tumor necrosis factor Homo sapiens 19-28
32896590-13 2021 CONCLUSION: Our study showed that MMP-3 was enhanced by high levels of uric acid, which promoted proteoglycan degradation, and induced MSU crystallization in turn. Uric Acid 71-80 matrix metallopeptidase 3 Homo sapiens 34-39
33413149-5 2021 RESULTS: FGF-23 was positively correlated with fasting blood-glucose, insulin resistance, serum creatinine, serum uric acid, LDL-C, high-sensitivity C-reactive protein, cardiac troponin I and N-terminal-proB-type natriuretic peptide, while was negatively associated with HDL-C and left ventricular ejection fraction (all P < 0.01). Uric Acid 114-123 fibroblast growth factor 23 Homo sapiens 9-15
33505510-0 2021 Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF-kB Signaling Pathway. Uric Acid 26-42 NLR family pyrin domain containing 3 Homo sapiens 85-90
33505510-5 2021 CA treatment markedly inhibited the degradation of IkappaBalpha and the activation of NF-kappaB signaling pathway and reduced the levels of its downstream inflammatory genes such as IL-1beta, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-M cells. Uric Acid 226-229 NFKB inhibitor alpha Homo sapiens 51-63
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 tumor necrosis factor Rattus norvegicus 77-86
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 interleukin 1 beta Rattus norvegicus 89-106
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 interleukin 1 alpha Rattus norvegicus 108-116
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 interleukin 6 Rattus norvegicus 119-123
33505510-6 2021 Therefore, we infer that CA effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, thereby reducing the activation of the NF-kappaB signaling pathway and the NLRP3 inflammasome. Uric Acid 51-54 NFKB inhibitor alpha Homo sapiens 110-122
33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 interleukin 18 Rattus norvegicus 129-134
33505510-6 2021 Therefore, we infer that CA effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, thereby reducing the activation of the NF-kappaB signaling pathway and the NLRP3 inflammasome. Uric Acid 51-54 nuclear factor kappa B subunit 1 Homo sapiens 163-172
33505510-6 2021 Therefore, we infer that CA effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, thereby reducing the activation of the NF-kappaB signaling pathway and the NLRP3 inflammasome. Uric Acid 51-54 NLR family pyrin domain containing 3 Homo sapiens 199-204
33993663-6 2021 The correlation analysis revealed a significant positive correlation between the level of TNF-alpha and uric acid (r<0,000001), between the concentration of TNF-alpha and the content of beta-Cross Laps (degradation products of type I collagen) (r=0,0001), as well as serum creatinine (r=0,002) and urea (p=0,00004) levels. Uric Acid 104-113 tumor necrosis factor Homo sapiens 90-99
32006266-3 2021 Clinical studies have demonstrated that in patients with type 2 diabetes, SGLT2 inhibitors resulted in sustained reductions in glycated hemoglobin (HbA1C), body weight, blood pressure and serum uric acid levels. Uric Acid 194-203 solute carrier family 5 member 2 Homo sapiens 74-79
33545795-0 2021 Analysis of the correlation between plasma coagulation factor VII, PAI-1, and uric acid with insulin resistance and macrovascular complications in elderly patients with type 2 diabetes. Uric Acid 78-87 insulin Homo sapiens 93-100
33232925-0 2021 Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway. Uric Acid 0-9 NLR family, pyrin domain containing 3 Mus musculus 68-73
33232925-2 2021 This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome-mediated pyroptosis. Uric Acid 28-37 NLR family, pyrin domain containing 3 Mus musculus 74-79
33232925-2 2021 This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome-mediated pyroptosis. Uric Acid 39-41 NLR family, pyrin domain containing 3 Mus musculus 74-79
33232925-10 2021 CONCLUSION: UA aggravates MI/R-induced activation of the NLRP3 inflammatory cascade and pyroptosis by promoting ROS generation, while inflammasome inhibitors and ROS scavengers partly reverse the injury. Uric Acid 12-14 NLR family, pyrin domain containing 3 Mus musculus 57-62
33128926-7 2021 In SCW and MSU crystal-induced arthritis, joint swelling, inflammatory cell influx, and synovial levels of IL-1beta, IL-6, and KC were reduced by 50% or greater. Uric Acid 11-14 interleukin 6 Mus musculus 117-121
31511642-0 2021 Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-beta-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system. Uric Acid 15-31 mitogen-activated protein kinase kinase kinase 7 Mus musculus 75-102
31511642-1 2021 Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1beta (IL-1beta) signaling. Uric Acid 0-16 interleukin 1 beta Mus musculus 81-98
31511642-7 2021 Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation, resulting in sustained TAK1 kinase activation. Uric Acid 89-98 mitogen-activated protein kinase kinase kinase 7 Mus musculus 47-51
31511642-7 2021 Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation, resulting in sustained TAK1 kinase activation. Uric Acid 89-98 mitogen-activated protein kinase kinase kinase 7 Mus musculus 134-138
31511642-7 2021 Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation, resulting in sustained TAK1 kinase activation. Uric Acid 89-98 mitogen-activated protein kinase kinase kinase 7 Mus musculus 134-138
33128926-7 2021 In SCW and MSU crystal-induced arthritis, joint swelling, inflammatory cell influx, and synovial levels of IL-1beta, IL-6, and KC were reduced by 50% or greater. Uric Acid 11-14 interleukin 1 alpha Mus musculus 107-115
33128926-9 2021 In MSU crystal-induced peritonitis, IL-38 reduced hypothermia, while plasma IL-6 and KC and peritoneal KC levels were reduced by 65-70%. Uric Acid 3-6 interleukin 1 family member 10 Homo sapiens 36-41
33227361-0 2021 Association between Plasma Uric Acid and Insulin Resistance in Type 2 Diabetes: A Mendelian Randomization Analysis. Uric Acid 27-36 insulin Homo sapiens 41-48
33227361-1 2021 OBJECTIVE: Circulating uric acid levels were associated with insulin resistance, but the causality is unclear. Uric Acid 23-32 insulin Homo sapiens 61-68
33310128-2 2021 Plasma IL-38 was higher in T2DM patients and positively related to waist/hip ratio, HbA1c, uric acid, liver function tests, triglycerides and total proteins. Uric Acid 91-100 interleukin 1 family member 10 Homo sapiens 7-12
33227361-2 2021 We aimed to investigate the association between plasma uric acid and insulin resistance in newly diagnosed type 2 diabetes (T2D). Uric Acid 55-64 insulin Homo sapiens 69-76
33227361-12 2021 CONCLUSIONS: Elevated plasma uric acid was associated with higher risk of insulin resistance, along with observation of gender difference in such association. Uric Acid 29-38 insulin Homo sapiens 74-81
33368618-2 2021 Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. Uric Acid 137-146 insulin Homo sapiens 74-81
33368618-2 2021 Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. Uric Acid 190-199 insulin Homo sapiens 74-81
33368618-7 2021 Our results suggest that in hypercholesterolemic conditions, elevated levels of 27HC derived from cholesterol induce URAT1/SLC22A12 expression to increase uric acid reabsorption, and thereby, could increase serum uric acid levels. Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 117-122
33368618-7 2021 Our results suggest that in hypercholesterolemic conditions, elevated levels of 27HC derived from cholesterol induce URAT1/SLC22A12 expression to increase uric acid reabsorption, and thereby, could increase serum uric acid levels. Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 123-131
33368618-4 2021 Here, we show that cholesterol metabolite 27-hydroxycholesterol (27HC) upregulates the uric acid reabsorption transporter URAT1 encoded by SLC22A12 via estrogen receptors (ER). Uric Acid 87-96 solute carrier family 22 member 12 Homo sapiens 122-127
33368618-4 2021 Here, we show that cholesterol metabolite 27-hydroxycholesterol (27HC) upregulates the uric acid reabsorption transporter URAT1 encoded by SLC22A12 via estrogen receptors (ER). Uric Acid 87-96 solute carrier family 22 member 12 Homo sapiens 139-147
33368618-4 2021 Here, we show that cholesterol metabolite 27-hydroxycholesterol (27HC) upregulates the uric acid reabsorption transporter URAT1 encoded by SLC22A12 via estrogen receptors (ER). Uric Acid 87-96 epiregulin Homo sapiens 152-170
33368618-4 2021 Here, we show that cholesterol metabolite 27-hydroxycholesterol (27HC) upregulates the uric acid reabsorption transporter URAT1 encoded by SLC22A12 via estrogen receptors (ER). Uric Acid 87-96 epiregulin Homo sapiens 172-174
33368618-5 2021 Transcriptional motif analysis showed that the SLC22A12 gene promoter has more estrogen response elements (EREs) than other uric acid reabsorption transporters such as SLC22A11 and SLC22A13, and 27HC-activated SLC22A12 gene promoter via ER through EREs. Uric Acid 124-133 solute carrier family 22 member 12 Homo sapiens 47-55
33091574-8 2021 CONCLUSIONS: We propose that the main mechanism by which quercetin, as quercetin-3"-sulfate, lowers uric acid in vivo is through inhibition of XOR, and not ADA nor PNP. Uric Acid 100-109 xanthine dehydrogenase Bos taurus 143-146
32789757-6 2021 Both, XO and XDH, catalyse the conversion of hypoxanthine via xanthine to uric acid, the former by using oxygen forming superoxide and hydrogen peroxide and the latter NAD+. Uric Acid 74-83 xanthine dehydrogenase Homo sapiens 13-16
33074353-0 2021 Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation. Uric Acid 0-9 translocator protein Mus musculus 56-60
33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 interleukin 1 alpha Homo sapiens 22-30
33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 interleukin 6 Homo sapiens 32-36
33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 C-C motif chemokine ligand 2 Homo sapiens 38-42
33074353-0 2021 Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation. Uric Acid 0-9 NLR family, pyrin domain containing 3 Mus musculus 70-75
33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 C-X-C motif chemokine ligand 8 Homo sapiens 47-51
33074353-14 2021 In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1. Uric Acid 33-42 translocator protein Mus musculus 77-81
33074353-14 2021 In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1. Uric Acid 33-42 NLR family, pyrin domain containing 3 Mus musculus 165-170
33074353-14 2021 In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1. Uric Acid 33-42 occludin Mus musculus 225-233
33074353-14 2021 In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1. Uric Acid 33-42 claudin 1 Mus musculus 238-247
33074353-17 2021 CONCLUSIONS: In conclusion, uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome. Uric Acid 28-37 translocator protein Mus musculus 84-88
33074353-17 2021 CONCLUSIONS: In conclusion, uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome. Uric Acid 28-37 NLR family, pyrin domain containing 3 Mus musculus 98-103
32350824-7 2021 RESULTS: Fetuin-A associated inversely with age (ss - 0.12, p = 0.03) and directly with body mass index (BMI) (ss 0.5, p = 0.048), waist circumference (WC) (ss 0.3, p = 0.027), triglycerides (TG) (ss 0.1, p = 0.001) and uric acid (ss 1.7, p = 0.018), after adjustment for age and sex. Uric Acid 220-229 alpha 2-HS glycoprotein Homo sapiens 9-17
33390768-8 2021 Results: With increasing hepassocin tertiles, patients had higher prevalence of fatty live, an increased waist-to-hip ratio, and neutrophil count, monocyte count, and FIB-4 index, higher levels of uric acid, blood urine nitrogen and higher sensitivity C-reactive protein. Uric Acid 197-206 fibrinogen like 1 Homo sapiens 25-35
32350824-8 2021 In a model including age, BMI, WC, TG and uric acid, age (ss - 0.2, p = 0.002) and TG (ss 0.04, p = 0.02) were independent predictors of fetuin-A. Uric Acid 42-51 alpha 2-HS glycoprotein Homo sapiens 137-145
33270240-3 2021 In vivo experiments in female Wistar rats demonstrated that alterations in urea, creatinine, and uric acid levels promoted (p < .05) by ketoprofen were reversed when AEG was co-administered. Uric Acid 97-106 cysteine-rich secretory protein 3 Rattus norvegicus 166-169
33427619-3 2021 METHODS: Soluble MICA (sMICA) was quantified by ELISA is synovial fluids harvested from patients suffering osteoarthritis, rheumatoid arthritis, psoriatic arthritis, calcium pyrophosphate crystal arthritis, urate crystal arthritis and reactive arthritis. Uric Acid 207-212 MHC class I polypeptide-related sequence A Homo sapiens 17-21
33427619-4 2021 Transcripts encoding murine NKG2DLs were quantified by RT-qPCR in the joints of mouse models of rheumatoid arthritis, urate crystal arthritis and osteoarthritis. Uric Acid 118-123 killer cell lectin like receptor C1 Homo sapiens 28-35
32761488-6 2021 Moreover, the increasing IL-1beta, IL-6, and TNF-alpha levels induced by MSU were decreased via administration of dioscin in mice and human synoviocytes. Uric Acid 73-76 interleukin 1 alpha Mus musculus 25-33
32761488-6 2021 Moreover, the increasing IL-1beta, IL-6, and TNF-alpha levels induced by MSU were decreased via administration of dioscin in mice and human synoviocytes. Uric Acid 73-76 interleukin 6 Mus musculus 35-39
32761488-6 2021 Moreover, the increasing IL-1beta, IL-6, and TNF-alpha levels induced by MSU were decreased via administration of dioscin in mice and human synoviocytes. Uric Acid 73-76 tumor necrosis factor Mus musculus 45-54
32761488-10 2021 Taken together, dioscin had a protective effect against MSU-initiated inflammatory response via repressing the production of inflammatory cytokines and the activation of inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway. Uric Acid 56-59 NLR family, pyrin domain containing 3 Mus musculus 183-188
32761488-10 2021 Taken together, dioscin had a protective effect against MSU-initiated inflammatory response via repressing the production of inflammatory cytokines and the activation of inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway. Uric Acid 56-59 toll-like receptor 4 Mus musculus 193-197
32761488-10 2021 Taken together, dioscin had a protective effect against MSU-initiated inflammatory response via repressing the production of inflammatory cytokines and the activation of inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway. Uric Acid 56-59 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 198-207
33682725-3 2021 OBJECTIVE: The aim of this study was to determine whether there are longitudinal differences in serum uric acid between iPD, LRRK2 + PD and HC and their association with motor and non-motor features. Uric Acid 102-111 leucine rich repeat kinase 2 Homo sapiens 125-130
33682725-6 2021 RESULTS: Longitudinal uric acid measurements were significantly lower in LRRK2 + PD patients compared to HC up to 5 years follow-up. Uric Acid 22-31 leucine rich repeat kinase 2 Homo sapiens 73-78
33682725-0 2021 Serum Uric Acid in LRRK2 Related Parkinson"s Disease: Longitudinal Data from the PPMI Study. Uric Acid 6-15 leucine rich repeat kinase 2 Homo sapiens 19-24
33682725-2 2021 Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK + 2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2 + PD and healthy controls (HC) has not been performed. Uric Acid 54-63 leucine rich repeat kinase 2 Homo sapiens 67-95
33682725-8 2021 CONCLUSION: LRRK2 + PD group had significantly lower uric acid concentrations compared to HC after adjusting for age, sex and baseline BMI up to 5 years follow-up. Uric Acid 53-62 leucine rich repeat kinase 2 Homo sapiens 12-17
33682725-2 2021 Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK + 2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2 + PD and healthy controls (HC) has not been performed. Uric Acid 54-63 leucine rich repeat kinase 2 Homo sapiens 97-105
33682725-10 2021 These findings identify serum uric acid as a marker linked to LRRK2 + PD. Uric Acid 30-39 leucine rich repeat kinase 2 Homo sapiens 62-67
32959172-0 2021 Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. Uric Acid 0-9 interleukin 6 Rattus norvegicus 40-44
32148148-0 2021 Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib. Uric Acid 0-9 interleukin 6 Homo sapiens 46-50
32148148-8 2021 Pretreatment with baricitinib, which blocks IL-6 receptor signalling, prevented MSU-induced cleaved caspase-1 or IL-1beta induction in IL-6-primed neutrophils. Uric Acid 80-83 interleukin 6 Homo sapiens 44-48
32148148-9 2021 Tocilizumab pretreatment also inhibited MSU-mediated IL-1beta production from IL-6-primed neutrophilsConclusions: Priming of human neutrophils with IL-6 promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation. Uric Acid 162-171 interleukin 6 Homo sapiens 148-152
32959172-0 2021 Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke. Uric Acid 0-9 signal transducer and activator of transcription 3 Rattus norvegicus 45-50
32959172-9 2021 In conclusion, the mechanism for morphological and functional neuroprotection by UA in ischemic stroke is multifaceted, since it is associated to activation of the IL-6/STAT3 pathway, attenuation of edematogenic VEGF-A/MMP-9 signaling, and modulation of relevant mediators of oxidative stress, neuroinflammation, and apoptotic cell death. Uric Acid 81-83 interleukin 6 Rattus norvegicus 164-168
32959172-9 2021 In conclusion, the mechanism for morphological and functional neuroprotection by UA in ischemic stroke is multifaceted, since it is associated to activation of the IL-6/STAT3 pathway, attenuation of edematogenic VEGF-A/MMP-9 signaling, and modulation of relevant mediators of oxidative stress, neuroinflammation, and apoptotic cell death. Uric Acid 81-83 signal transducer and activator of transcription 3 Rattus norvegicus 169-174
32959172-9 2021 In conclusion, the mechanism for morphological and functional neuroprotection by UA in ischemic stroke is multifaceted, since it is associated to activation of the IL-6/STAT3 pathway, attenuation of edematogenic VEGF-A/MMP-9 signaling, and modulation of relevant mediators of oxidative stress, neuroinflammation, and apoptotic cell death. Uric Acid 81-83 vascular endothelial growth factor A Rattus norvegicus 212-218
32959172-9 2021 In conclusion, the mechanism for morphological and functional neuroprotection by UA in ischemic stroke is multifaceted, since it is associated to activation of the IL-6/STAT3 pathway, attenuation of edematogenic VEGF-A/MMP-9 signaling, and modulation of relevant mediators of oxidative stress, neuroinflammation, and apoptotic cell death. Uric Acid 81-83 matrix metallopeptidase 9 Rattus norvegicus 219-224
33242555-0 2021 Andrographolide inhibits IL-1beta release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate. Uric Acid 135-151 interleukin 1 alpha Mus musculus 25-33
32734364-6 2021 Findings of this work displayed that the renal contents of the vitamin C, superoxide dismutase (SOD), and catalase (CAT) significantly reduced and the levels of the serum protein carbonyl, creatinine, serum glutamate pyruvate transaminase (sGPT), urea, serum glutamate oxaloacetate transaminase (sGOT), uric acid, MDA, serum IL-1beta, and the kidney IL-1beta gene expression were remarkably increased in the group receiving PRQ only compared with that in the control group. Uric Acid 303-312 catalase Rattus norvegicus 116-119
33121989-8 2021 In the UUO-Gas5+/- group, the serum levels of uric acid, serum creatinine, and the urine levels of albumin-to-creatinine ratio were higher. Uric Acid 46-55 growth arrest specific 5 Mus musculus 11-15
33242555-3 2021 Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome. Uric Acid 0-16 NLR family, pyrin domain containing 3 Mus musculus 67-72
33242555-3 2021 Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome. Uric Acid 0-16 NLR family, pyrin domain containing 3 Mus musculus 74-110
33242555-3 2021 Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome. Uric Acid 18-21 NLR family, pyrin domain containing 3 Mus musculus 67-72
33242555-3 2021 Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome. Uric Acid 18-21 NLR family, pyrin domain containing 3 Mus musculus 74-110
33242555-7 2021 AND suppressed MSU phagocytosis dose-dependently and markedly inhibited LPS- and MSU-induced IL-1beta release in BMDMs. Uric Acid 15-18 interleukin 1 alpha Mus musculus 93-101
33242555-7 2021 AND suppressed MSU phagocytosis dose-dependently and markedly inhibited LPS- and MSU-induced IL-1beta release in BMDMs. Uric Acid 81-84 interleukin 1 alpha Mus musculus 93-101
33242555-9 2021 AND induced HO-1 protein expression in a dose-dependent manner and attenuated MSU-induced ROS generation. Uric Acid 78-81 heme oxygenase 1 Mus musculus 12-16
33242555-10 2021 Silencing HO-1 mitigated AND inhibition of LPS/MSU-induced IL-1beta release in J774A.1 cells. Uric Acid 47-50 heme oxygenase 1 Mus musculus 10-14
33242555-10 2021 Silencing HO-1 mitigated AND inhibition of LPS/MSU-induced IL-1beta release in J774A.1 cells. Uric Acid 47-50 interleukin 1 alpha Mus musculus 59-67
33242555-11 2021 In addition, AND decreased MSU-mediated ASC binding to NLRP3. Uric Acid 27-30 NLR family, pyrin domain containing 3 Mus musculus 55-60
33242555-13 2021 These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release. Uric Acid 78-81 heme oxygenase 1 Mus musculus 122-126
33242555-13 2021 These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release. Uric Acid 78-81 NLR family, pyrin domain containing 3 Mus musculus 169-174
33242555-13 2021 These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release. Uric Acid 78-81 interleukin 1 alpha Mus musculus 212-220
33488933-0 2020 HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-kappaB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function. Uric Acid 16-32 heat shock protein family D (Hsp60) member 1 Homo sapiens 0-5
33728852-7 2021 In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <> antioxidant capacity. Uric Acid 112-121 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42
33728852-7 2021 In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <> antioxidant capacity. Uric Acid 112-121 NFE2 like bZIP transcription factor 2 Homo sapiens 207-211
33728852-9 2021 The absence of a correlation between the total antioxidant capacity and the level of Nrf2 in patients with schizophrenia indicates a disturbance of the activation of the Nrf2 pathway due to, possibly, a part associated with the participation of uric acid. Uric Acid 245-254 NFE2 like bZIP transcription factor 2 Homo sapiens 170-174
33517955-4 2021 The relationship between serum uric acid level and MoCA score was analyzed. Uric Acid 31-40 dedicator of cytokinesis 3 Homo sapiens 51-55
33517955-13 2021 05), and the MoCA score of the subjects in this group was significantly positively correlated with the serum uric acid level(r=0. Uric Acid 109-118 dedicator of cytokinesis 3 Homo sapiens 13-17
33488933-0 2020 HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-kappaB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function. Uric Acid 16-32 MYD88 innate immune signal transduction adaptor Homo sapiens 95-100
33488933-5 2020 The effect and molecular mechanism of HSP60 in gout were studied in MSU crystals treatment macrophages and C57BL/6 mice. Uric Acid 68-71 heat shock protein 1 (chaperonin) Mus musculus 38-43
33488933-0 2020 HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-kappaB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function. Uric Acid 16-32 toll like receptor 4 Homo sapiens 80-84
33488933-8 2020 MSU crystals induced the expression and secretion of HSP60 in the macrophages. Uric Acid 0-3 heat shock protein family D (Hsp60) member 1 Homo sapiens 53-58
33488933-0 2020 HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-kappaB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function. Uric Acid 16-32 nuclear factor kappa B subunit 1 Homo sapiens 85-94
33488933-12 2020 Our study reveals that MSU crystal stimulates the expression of HSP60, which accelerates the TLR4-MyD88-NF-kappaB signaling pathway and exacerbates mitochondrial dysfunction. Uric Acid 23-26 heat shock protein 1 (chaperonin) Mus musculus 64-69
33426022-10 2020 The present result suggests that an adequate level of uric acid is helpful in alleviating the acute oxidative damage that is induced by high glucose, whereas the inhibition of the Nrf2 pathway by a high level of uric acid may render the cardiac myocytes more vulnerable to suffering from oxidative damage. Uric Acid 212-221 nuclear factor, erythroid 2 like 2 Gallus gallus 180-184
33488933-12 2020 Our study reveals that MSU crystal stimulates the expression of HSP60, which accelerates the TLR4-MyD88-NF-kappaB signaling pathway and exacerbates mitochondrial dysfunction. Uric Acid 23-26 toll like receptor 4 Homo sapiens 93-97
33488933-12 2020 Our study reveals that MSU crystal stimulates the expression of HSP60, which accelerates the TLR4-MyD88-NF-kappaB signaling pathway and exacerbates mitochondrial dysfunction. Uric Acid 23-26 MYD88 innate immune signal transduction adaptor Homo sapiens 98-103
33488933-12 2020 Our study reveals that MSU crystal stimulates the expression of HSP60, which accelerates the TLR4-MyD88-NF-kappaB signaling pathway and exacerbates mitochondrial dysfunction. Uric Acid 23-26 nuclear factor kappa B subunit 1 Homo sapiens 104-113
33371241-5 2020 We also examined oedema, pain, and inflammation in MSU-induced mice by measuring affected hind paw swelling, weight-bearing, pro-inflammatory cytokines levels, and myeloperoxidase (MPO) activity. Uric Acid 51-54 myeloperoxidase Mus musculus 164-179
33371241-5 2020 We also examined oedema, pain, and inflammation in MSU-induced mice by measuring affected hind paw swelling, weight-bearing, pro-inflammatory cytokines levels, and myeloperoxidase (MPO) activity. Uric Acid 51-54 myeloperoxidase Mus musculus 181-184
28520356-0 2012 Allopurinol Therapy and HLA-B*58:01 Genotype Allopurinol is a xanthine oxidase inhibitor that decreases the production of uric acid. Uric Acid 122-131 major histocompatibility complex, class I, B Homo sapiens 24-29
33321761-0 2020 Integrated EC-SERS Chip with Uniform Nanostructured EC-SERS Active Working Electrode for Rapid Detection of Uric Acid. Uric Acid 108-117 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 14-18
33321761-14 2020 The EC-SERS chip developed has been further tested for the detection of uric acid in synthetic urine. Uric Acid 72-81 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 7-11
33403304-2 2020 However, the molecular interactions between uric acid and URAT1 are still unknown due to lack of structural details. Uric Acid 44-53 solute carrier family 22 member 12 Homo sapiens 58-63
33403304-3 2020 Methods: In the present study, several methods (homology modeling, sequence alignment, docking, and mutagenesis) were used to explain the atomistic mechanisms of uric acid transport of hURAT1. Uric Acid 162-171 solute carrier family 22 member 12 Homo sapiens 185-191
33403304-4 2020 Results: Residues W357-F365 in the TMD7 and P484-R487 in the TMD11 present in the hURAT1 have unique roles in both binding to the uric acid and causing subsequent structural changes. Uric Acid 130-139 solute carrier family 22 member 12 Homo sapiens 82-88
33321761-15 2020 The results showed that the EC-SERS signal intensity has a highly linear relationship with the logarithm of the uric acid concentration in synthetic urine, which indicates that the developed EC-SERS chip is suitable for the quantitative detection of uric acid in synthetic urine. Uric Acid 112-121 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 31-35
33321761-15 2020 The results showed that the EC-SERS signal intensity has a highly linear relationship with the logarithm of the uric acid concentration in synthetic urine, which indicates that the developed EC-SERS chip is suitable for the quantitative detection of uric acid in synthetic urine. Uric Acid 112-121 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 194-198
33321761-15 2020 The results showed that the EC-SERS signal intensity has a highly linear relationship with the logarithm of the uric acid concentration in synthetic urine, which indicates that the developed EC-SERS chip is suitable for the quantitative detection of uric acid in synthetic urine. Uric Acid 250-259 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 31-35
33321761-15 2020 The results showed that the EC-SERS signal intensity has a highly linear relationship with the logarithm of the uric acid concentration in synthetic urine, which indicates that the developed EC-SERS chip is suitable for the quantitative detection of uric acid in synthetic urine. Uric Acid 250-259 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 194-198
32827538-10 2020 Overall, promoting intestinal elimination of urate by upregulating ABCG2 expression and downregulating GLUT9 expression might be an important mechanism underlying mangiferin lowering serum uric acid levels. Uric Acid 45-50 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 67-72
33363539-6 2020 We show that recombinant versions of both human and mouse MARCO directly bind to unopsonized MSU and several other disease-associated crystals. Uric Acid 93-96 macrophage receptor with collagenous structure Mus musculus 58-63
33363539-12 2020 The inhibition of neutrophil ROS production only partly correlated with the inhibition of IL-1beta production by peripheral blood mononuclear cells (PBMCs): LDL inhibited IL-1beta production in response to large MSU crystals, but not small MSU or silica crystals. Uric Acid 212-215 interleukin 1 alpha Homo sapiens 90-98
33363539-12 2020 The inhibition of neutrophil ROS production only partly correlated with the inhibition of IL-1beta production by peripheral blood mononuclear cells (PBMCs): LDL inhibited IL-1beta production in response to large MSU crystals, but not small MSU or silica crystals. Uric Acid 212-215 interleukin 1 alpha Homo sapiens 171-179
32827538-10 2020 Overall, promoting intestinal elimination of urate by upregulating ABCG2 expression and downregulating GLUT9 expression might be an important mechanism underlying mangiferin lowering serum uric acid levels. Uric Acid 45-50 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 103-108
32827538-10 2020 Overall, promoting intestinal elimination of urate by upregulating ABCG2 expression and downregulating GLUT9 expression might be an important mechanism underlying mangiferin lowering serum uric acid levels. Uric Acid 189-198 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 103-108
32734505-9 2020 After adjusting for gender and age, serum CTRP12 level was negatively correlated with the duration of diabetes, blood urea nitrogen (BUN), uric acid (UA) and 24-h urinary albumin excretion rate (UAE) in T2DM patients. Uric Acid 139-148 C1q and TNF related 12 Homo sapiens 42-48
33437769-0 2020 Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway. Uric Acid 0-9 mitogen-activated protein kinase 8 Mus musculus 57-60
33437769-0 2020 Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway. Uric Acid 0-9 gap junction protein, alpha 3 Mus musculus 76-80
33437769-0 2020 Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway. Uric Acid 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 141-145
33437769-0 2020 Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway. Uric Acid 0-9 protein tyrosine phosphatase, non-receptor type 11 Mus musculus 146-150
33437769-14 2020 Uric acid also effectively alleviated prolongation of the doxorubicin-induced QT interval, slowed heart rate, and reduced the plasma levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) in plasma in mice. Uric Acid 0-9 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 143-169
33437769-14 2020 Uric acid also effectively alleviated prolongation of the doxorubicin-induced QT interval, slowed heart rate, and reduced the plasma levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) in plasma in mice. Uric Acid 0-9 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 171-174
33437769-15 2020 Moreover, uric acid strongly activated AMPK and Src homology 2 domain-containing protein tyrosine phosphatase (SHP2), inhibiting doxorubicin-induced expression phosphorylated-c-Jun N-terminal kinases (JNK) and phosphorylated-connexin 43 (Cx43) in vitro and in vivo and effectively reversing the doxorubicin-induced decreased viability of H9C2 myocardial cells in vitro. Uric Acid 10-19 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 39-43
33437769-15 2020 Moreover, uric acid strongly activated AMPK and Src homology 2 domain-containing protein tyrosine phosphatase (SHP2), inhibiting doxorubicin-induced expression phosphorylated-c-Jun N-terminal kinases (JNK) and phosphorylated-connexin 43 (Cx43) in vitro and in vivo and effectively reversing the doxorubicin-induced decreased viability of H9C2 myocardial cells in vitro. Uric Acid 10-19 protein tyrosine phosphatase, non-receptor type 11 Rattus norvegicus 111-115
33437769-15 2020 Moreover, uric acid strongly activated AMPK and Src homology 2 domain-containing protein tyrosine phosphatase (SHP2), inhibiting doxorubicin-induced expression phosphorylated-c-Jun N-terminal kinases (JNK) and phosphorylated-connexin 43 (Cx43) in vitro and in vivo and effectively reversing the doxorubicin-induced decreased viability of H9C2 myocardial cells in vitro. Uric Acid 10-19 mitogen-activated protein kinase 8 Rattus norvegicus 201-204
33437769-15 2020 Moreover, uric acid strongly activated AMPK and Src homology 2 domain-containing protein tyrosine phosphatase (SHP2), inhibiting doxorubicin-induced expression phosphorylated-c-Jun N-terminal kinases (JNK) and phosphorylated-connexin 43 (Cx43) in vitro and in vivo and effectively reversing the doxorubicin-induced decreased viability of H9C2 myocardial cells in vitro. Uric Acid 10-19 gap junction protein, alpha 1 Rattus norvegicus 225-236
33437769-15 2020 Moreover, uric acid strongly activated AMPK and Src homology 2 domain-containing protein tyrosine phosphatase (SHP2), inhibiting doxorubicin-induced expression phosphorylated-c-Jun N-terminal kinases (JNK) and phosphorylated-connexin 43 (Cx43) in vitro and in vivo and effectively reversing the doxorubicin-induced decreased viability of H9C2 myocardial cells in vitro. Uric Acid 10-19 gap junction protein, alpha 1 Rattus norvegicus 238-242
33437769-16 2020 Conclusions: We demonstrated that uric acid preconditioning alleviated doxorubicin-induced cardiotoxicity through the AMPK-SHP2-JNK-Cx43 signaling pathway. Uric Acid 34-43 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 118-122
33437769-16 2020 Conclusions: We demonstrated that uric acid preconditioning alleviated doxorubicin-induced cardiotoxicity through the AMPK-SHP2-JNK-Cx43 signaling pathway. Uric Acid 34-43 protein tyrosine phosphatase, non-receptor type 11 Rattus norvegicus 123-127
33437769-16 2020 Conclusions: We demonstrated that uric acid preconditioning alleviated doxorubicin-induced cardiotoxicity through the AMPK-SHP2-JNK-Cx43 signaling pathway. Uric Acid 34-43 mitogen-activated protein kinase 8 Rattus norvegicus 128-131
33437769-16 2020 Conclusions: We demonstrated that uric acid preconditioning alleviated doxorubicin-induced cardiotoxicity through the AMPK-SHP2-JNK-Cx43 signaling pathway. Uric Acid 34-43 gap junction protein, alpha 1 Rattus norvegicus 132-136
33120237-18 2020 The molecular mechanism appears to involve the regulation of urate transport-related transporters including renal ABCG2, URAT1, and PDZK1, and intestinal GLUT9 and ABCG2, as well as the inhibition of the LPS/TLR4/NF-kappaB signaling to reduce IL-6, IL-8, and TNF-alpha secretion in hyperuricemic rats. Uric Acid 61-66 ATP binding cassette subfamily G member 2 Rattus norvegicus 114-119
33120237-18 2020 The molecular mechanism appears to involve the regulation of urate transport-related transporters including renal ABCG2, URAT1, and PDZK1, and intestinal GLUT9 and ABCG2, as well as the inhibition of the LPS/TLR4/NF-kappaB signaling to reduce IL-6, IL-8, and TNF-alpha secretion in hyperuricemic rats. Uric Acid 61-66 PDZ domain containing 1 Rattus norvegicus 132-137
33120237-18 2020 The molecular mechanism appears to involve the regulation of urate transport-related transporters including renal ABCG2, URAT1, and PDZK1, and intestinal GLUT9 and ABCG2, as well as the inhibition of the LPS/TLR4/NF-kappaB signaling to reduce IL-6, IL-8, and TNF-alpha secretion in hyperuricemic rats. Uric Acid 61-66 toll-like receptor 4 Rattus norvegicus 208-212
33120237-18 2020 The molecular mechanism appears to involve the regulation of urate transport-related transporters including renal ABCG2, URAT1, and PDZK1, and intestinal GLUT9 and ABCG2, as well as the inhibition of the LPS/TLR4/NF-kappaB signaling to reduce IL-6, IL-8, and TNF-alpha secretion in hyperuricemic rats. Uric Acid 61-66 interleukin 6 Rattus norvegicus 243-247
33120237-18 2020 The molecular mechanism appears to involve the regulation of urate transport-related transporters including renal ABCG2, URAT1, and PDZK1, and intestinal GLUT9 and ABCG2, as well as the inhibition of the LPS/TLR4/NF-kappaB signaling to reduce IL-6, IL-8, and TNF-alpha secretion in hyperuricemic rats. Uric Acid 61-66 tumor necrosis factor Rattus norvegicus 259-268
33096031-5 2020 Xanthine dehydrogenase converted the hypoxanthine to uric acid and yielded two molecules of NADH, which in turn reduced Fe3+ to Fe2+ (mediated by 1-methoxy-5-ethylphenazinium ethylsulfate). Uric Acid 53-62 xanthine dehydrogenase Homo sapiens 0-22
32700178-0 2020 Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1beta Production Through Monosodium Urate-Induced Mitochondrial DNA. Uric Acid 98-114 toll-like receptor 9 Mus musculus 0-20
32700178-0 2020 Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1beta Production Through Monosodium Urate-Induced Mitochondrial DNA. Uric Acid 98-114 NLR family, pyrin domain containing 3 Mus musculus 36-41
32700178-0 2020 Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1beta Production Through Monosodium Urate-Induced Mitochondrial DNA. Uric Acid 98-114 interleukin 1 alpha Mus musculus 70-78
32700178-1 2020 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1beta and is considered a main pathogenic mechanism for uric acid-induced inflammation. Uric Acid 190-199 NLR family, pyrin domain containing 3 Mus musculus 4-40
32700178-1 2020 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1beta and is considered a main pathogenic mechanism for uric acid-induced inflammation. Uric Acid 190-199 NLR family, pyrin domain containing 3 Mus musculus 42-47
32700178-1 2020 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1beta and is considered a main pathogenic mechanism for uric acid-induced inflammation. Uric Acid 190-199 interleukin 1 alpha Mus musculus 117-139
32700178-2 2020 Whether toll-like receptor 9 (TLR9) is responsible for uric acid-induced NLRP3 inflammasome activation remains unclear. Uric Acid 55-64 toll-like receptor 9 Mus musculus 8-28
32700178-2 2020 Whether toll-like receptor 9 (TLR9) is responsible for uric acid-induced NLRP3 inflammasome activation remains unclear. Uric Acid 55-64 toll-like receptor 9 Mus musculus 30-34
32700178-2 2020 Whether toll-like receptor 9 (TLR9) is responsible for uric acid-induced NLRP3 inflammasome activation remains unclear. Uric Acid 55-64 NLR family, pyrin domain containing 3 Mus musculus 73-78
32700178-3 2020 Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA. Uric Acid 102-118 toll-like receptor 9 Mus musculus 56-60
32700178-3 2020 Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA. Uric Acid 102-118 NLR family, pyrin domain containing 3 Mus musculus 64-69
32700178-3 2020 Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA. Uric Acid 120-123 toll-like receptor 9 Mus musculus 56-60
32700178-3 2020 Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA. Uric Acid 120-123 NLR family, pyrin domain containing 3 Mus musculus 64-69
32700178-10 2020 CpG-ODN and MSU crystals augmented the activation of NLRP3 inflammasome components and IL-1beta expression, which was significantly suppressed in RAW 264.7 cells transfected with TLR9 siRNA. Uric Acid 12-15 NLR family, pyrin domain containing 3 Mus musculus 53-58
32700178-10 2020 CpG-ODN and MSU crystals augmented the activation of NLRP3 inflammasome components and IL-1beta expression, which was significantly suppressed in RAW 264.7 cells transfected with TLR9 siRNA. Uric Acid 12-15 interleukin 1 alpha Mus musculus 87-95
32700178-10 2020 CpG-ODN and MSU crystals augmented the activation of NLRP3 inflammasome components and IL-1beta expression, which was significantly suppressed in RAW 264.7 cells transfected with TLR9 siRNA. Uric Acid 12-15 toll-like receptor 9 Mus musculus 179-183
32700178-11 2020 This study suggests that TLR9 activated by MSU crystal-mediated mitochondrial DNA contributes to the activation of NLRP3 inflammasomes and IL-1beta production. Uric Acid 43-46 toll-like receptor 9 Mus musculus 25-29
32700178-11 2020 This study suggests that TLR9 activated by MSU crystal-mediated mitochondrial DNA contributes to the activation of NLRP3 inflammasomes and IL-1beta production. Uric Acid 43-46 NLR family, pyrin domain containing 3 Mus musculus 115-120
32700178-11 2020 This study suggests that TLR9 activated by MSU crystal-mediated mitochondrial DNA contributes to the activation of NLRP3 inflammasomes and IL-1beta production. Uric Acid 43-46 interleukin 1 alpha Mus musculus 139-147
33017103-9 2020 Basic Protocol 4 describes how to induce NLRP3 inflammasome activation and peritonitis by priming mice with LPS and subsequently challenging them with monosodium urate (MSU). Uric Acid 151-167 NLR family, pyrin domain containing 3 Mus musculus 41-46
33017103-9 2020 Basic Protocol 4 describes how to induce NLRP3 inflammasome activation and peritonitis by priming mice with LPS and subsequently challenging them with monosodium urate (MSU). Uric Acid 169-172 NLR family, pyrin domain containing 3 Mus musculus 41-46
33015850-5 2020 Here we also review the clinical importance of altered ABCG2 expression and function in general drug metabolism, cancer multidrug resistance and impaired uric acid excretion, leading to gout. Uric Acid 154-163 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 55-60
32886146-12 2020 In macrophages, IL-33 enhanced the release of IL-1beta and TNF-alpha, and BMDMs from ST2-/- showed reduced levels of these cytokines after stimulus with MSU crystals. Uric Acid 153-156 interleukin 33 Mus musculus 16-21
32886146-12 2020 In macrophages, IL-33 enhanced the release of IL-1beta and TNF-alpha, and BMDMs from ST2-/- showed reduced levels of these cytokines after stimulus with MSU crystals. Uric Acid 153-156 interleukin 1 receptor-like 1 Mus musculus 85-88
32886146-13 2020 CONCLUSION: IL-33 mediates gout pain and inflammation by boosting macrophages production of cytokines upon MSU crystals stimulus. Uric Acid 107-110 interleukin 33 Mus musculus 12-17
32734505-9 2020 After adjusting for gender and age, serum CTRP12 level was negatively correlated with the duration of diabetes, blood urea nitrogen (BUN), uric acid (UA) and 24-h urinary albumin excretion rate (UAE) in T2DM patients. Uric Acid 150-152 C1q and TNF related 12 Homo sapiens 42-48
32737930-1 2020 WHAT IS KNOWN AND OBJECTIVE: There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Uric Acid 167-176 angiotensin I converting enzyme Homo sapiens 106-135
33245573-8 2020 Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1beta in alcohol use disorder patients with ALD and were increased in Camp-/- mice fed alcohol. Uric Acid 16-25 interleukin 1 alpha Homo sapiens 128-136
32346123-2 2020 Preclinical studies demonstrate uric acid increases BP via increased renin-angiotensin system (RAS) expression, especially angiotensin (Ang) II, but the association of uric acid with Ang-(1-7) is unknown. Uric Acid 168-177 angiopoietin 1 Homo sapiens 183-191
32346123-5 2020 We hypothesized uric acid is associated with a higher ratio of Ang II to Ang-(1-7) in plasma, especially in preterm-born adolescents. Uric Acid 16-25 angiopoietin 1 Homo sapiens 73-81
32346123-9 2020 Higher Ang II/Ang-(1-7) was associated with higher uric acid in adolescents. Uric Acid 51-60 angiopoietin 1 Homo sapiens 14-22
33245573-8 2020 Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1beta in alcohol use disorder patients with ALD and were increased in Camp-/- mice fed alcohol. Uric Acid 16-25 cathelicidin antimicrobial peptide Homo sapiens 201-205
33245573-9 2020 In vitro studies showed that CRAMP peptide inhibited LPS binding to macrophages and inflammasome activation stimulated by a combination of LPS and UA. Uric Acid 147-149 cathelicidin antimicrobial peptide Mus musculus 29-34
33245573-11 2020 In summary, CRAMP exhibited a protective role against binge-on-chronic alcohol-induced liver damage via regulation of inflammasome activation by decreasing LPS binding and UA production. Uric Acid 172-174 cathelicidin antimicrobial peptide Mus musculus 12-17
32665641-5 2020 Additional mechanisms of SGLT2 inhibitors that might be beneficial include a reduction in adipose tissue-mediated inflammation and pro-inflammatory cytokine production, a shift towards ketone bodies as the metabolic substrate for the heart and kidneys, reduced oxidative stress, lowered serum uric acid level, reduced glomerular hyperfiltration and albuminuria, and suppression of advanced glycation end-product signalling. Uric Acid 293-302 solute carrier family 5 member 2 Homo sapiens 25-30
32905987-1 2020 Urate anion exchanger 1 (URAT1) expressed in the proximal renal tubules is responsible for about 90% of the reabsorption of uric acid. Uric Acid 124-133 solute carrier family 22 member 12 Homo sapiens 0-23
33251779-11 2020 CONCLUSION: Our data demonstrated a potential role of Hcy and UA on PNP in de novo patients with PD. Uric Acid 62-64 purine nucleoside phosphorylase Homo sapiens 68-71
33131902-2 2020 Many triggers, including microbial pathogens (ie, bacteria and viruses) and other signals (ie, reactive oxygen species, adenosine triphosphate, urate, silicon, and asbestos), can stimulate the NLRP3 inflammasome. Uric Acid 144-149 NLR family pyrin domain containing 3 Homo sapiens 193-198
33254150-3 2021 Furthermore, we characterized the effect of the complexes of UA with ACBs on the expression of inflammatory biomarkers in human hepatoma HepG2 cell lines through C-reactive protein (CRP) western blot. Uric Acid 61-63 C-reactive protein Homo sapiens 162-180
33254150-3 2021 Furthermore, we characterized the effect of the complexes of UA with ACBs on the expression of inflammatory biomarkers in human hepatoma HepG2 cell lines through C-reactive protein (CRP) western blot. Uric Acid 61-63 C-reactive protein Homo sapiens 182-185
33254150-4 2021 The results showed UA molecules can be recognized by three ACBs with different binding constants, and ACBs successfully blocked the inflammatory stimulation of uric acid on HepG2 cell lines and inhibited the expression of the major inflammatory factor CRP by formations of complexes between UA and ACBs. Uric Acid 19-21 C-reactive protein Homo sapiens 252-255
33254150-4 2021 The results showed UA molecules can be recognized by three ACBs with different binding constants, and ACBs successfully blocked the inflammatory stimulation of uric acid on HepG2 cell lines and inhibited the expression of the major inflammatory factor CRP by formations of complexes between UA and ACBs. Uric Acid 291-293 C-reactive protein Homo sapiens 252-255
32905987-1 2020 Urate anion exchanger 1 (URAT1) expressed in the proximal renal tubules is responsible for about 90% of the reabsorption of uric acid. Uric Acid 124-133 solute carrier family 22 member 12 Homo sapiens 25-30
32905987-3 2020 Here we present an LC-MS/MS-based approach, combined with URAT1-transgenic MDCK cells, for the assessment of uric acid. Uric Acid 109-118 solute carrier family 22 member 12 Canis lupus familiaris 58-63
32905987-10 2020 Uric acid uptake showed concentration and time dependency in URAT1-transgenic cells. Uric Acid 0-9 solute carrier family 22 member 12 Canis lupus familiaris 61-66
33330529-3 2020 We targeted intestinal degradation of urate in vivo with ALLN-346, an orally administered, engineered urate oxidase, optimized for proteolytic stability, and activity in the gut. Uric Acid 38-43 urate oxidase Mus musculus 102-115
33817272-5 2020 Results: Logistic regression analysis found that FTO rs1477196 was significantly associated with the susceptibility to NAFLD in recessive genetic models [unadjusted odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.22-5.19, P = 0.012] and the relativity weakened after further adjustment for body mass index (BMI), uric acid, metabolic syndrome, smoking, and drinking (adjusted OR = 2.18, 95% CI: 0.96-4.99, P = 0.06). Uric Acid 321-330 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 49-52
33330529-9 2020 Oral enzyme therapy with engineered urate oxidase (ALLN-346) designed to degrade urate in the intestinal tract has the potential to reduce hyperuricemia and the renal burden of filtered urate in patients with hyperuricemia and gout with and without CKD. Uric Acid 81-86 urate oxidase Mus musculus 36-49
33330592-2 2020 Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD. Uric Acid 132-141 parathyroid hormone Homo sapiens 75-94
32893671-1 2020 Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric Acid 146-155 xanthine dehydrogenase Homo sapiens 0-23
33211396-1 2021 AIMS: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Uric Acid 106-115 xanthine dehydrogenase Homo sapiens 6-29
33211396-1 2021 AIMS: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Uric Acid 106-115 xanthine dehydrogenase Homo sapiens 31-34
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 95-111 NLR family, pyrin domain containing 3 Rattus norvegicus 79-84
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 95-111 interleukin 1 alpha Rattus norvegicus 145-153
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 95-111 tumor necrosis factor Rattus norvegicus 158-167
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 113-116 NLR family, pyrin domain containing 3 Rattus norvegicus 79-84
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 113-116 interleukin 1 alpha Rattus norvegicus 145-153
32876675-7 2020 Treatment with rosiglitazone in vitro reduced the expression of NLRP3, and the NLRP3 activator monosodium urate (MSU) reversed the inhibition of IL-1beta and TNF-alpha by rosiglitazone in macrophages. Uric Acid 113-116 tumor necrosis factor Rattus norvegicus 158-167
32876675-8 2020 MSU reversed the protective effect of rosiglitazone on radiation-induced intestinal injury in rats by reversing the rosiglitazone-induced inhibition of IL-1beta and TNF-alpha. Uric Acid 0-3 interleukin 1 alpha Rattus norvegicus 152-160
32876675-8 2020 MSU reversed the protective effect of rosiglitazone on radiation-induced intestinal injury in rats by reversing the rosiglitazone-induced inhibition of IL-1beta and TNF-alpha. Uric Acid 0-3 tumor necrosis factor Rattus norvegicus 165-174
33055192-2 2020 In this systematic review, we aimed to evaluate the efficacy of urate-lowering therapy on major adverse cardiovascular events, all-cause mortality, kidney failure events, BP, and GFR. Uric Acid 64-69 Rap guanine nucleotide exchange factor 5 Homo sapiens 179-182
33055192-9 2020 Nevertheless, urate-lowering therapy attenuated the decline in the slope of GFR (weighted mean difference, 1.18 ml/min per 1.73 m2 per year; 95% confidence interval, 0.44 to 1.91) and lowered the mean BP (systolic BP: weighted mean difference, -3.45 mm Hg; 95% confidence interval, -6.10 to -0.80; diastolic BP: weighted mean difference, -2.02 mm Hg; 95% confidence interval, -3.25 to -0.78). Uric Acid 14-19 Rap guanine nucleotide exchange factor 5 Homo sapiens 76-79
32893671-1 2020 Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric Acid 146-155 xanthine dehydrogenase Homo sapiens 25-28
32893671-1 2020 Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric Acid 146-155 xanthine dehydrogenase Homo sapiens 63-85
32893671-3 2020 The lack of ascorbic acid, known as vitamin C, in hominoids has been thought to cause a compensatory increase in uric acid as an antioxidant by unfunctional gene mutation of uricase to a pseudogene. Uric Acid 113-122 urate oxidase (pseudogene) Homo sapiens 174-181
32893671-8 2020 Treatment with an XOR inhibitor can decrease uric acid for preventing gout, reduce production of XO-related ROS, and promote reutilization of hypoxanthine and ATP production through the salvage pathway. Uric Acid 45-54 xanthine dehydrogenase Homo sapiens 18-21
33302685-5 2020 We drawed conclusions as follows: TNF antagonists etanercept can alleviate the acute inflammatory response of gouty arthritis and ensure uric acid-lowering therapy. Uric Acid 137-146 tumor necrosis factor Homo sapiens 34-37
32699039-5 2020 RESULTS: We observed that MSU and CPP crystals led to a metabolic rewiring toward the aerobic glycolysis pathway explained by an increase in GLUT1 plasma membrane expression and glucose uptake on macrophages. Uric Acid 26-29 solute carrier family 2 member 1 Homo sapiens 141-146
32699039-8 2020 CONCLUSION: In conclusion, we demonstrated that GLUT1-mediated glucose uptake is instrumental during the inflammatory IL-1beta response induced by MSU and CPP crystals. Uric Acid 147-150 solute carrier family 2 member 1 Homo sapiens 48-53
32699039-8 2020 CONCLUSION: In conclusion, we demonstrated that GLUT1-mediated glucose uptake is instrumental during the inflammatory IL-1beta response induced by MSU and CPP crystals. Uric Acid 147-150 interleukin 1 alpha Homo sapiens 118-126
32699039-1 2020 OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively. Uric Acid 36-52 interleukin 1 alpha Homo sapiens 112-134
32699039-1 2020 OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively. Uric Acid 54-57 interleukin 1 alpha Homo sapiens 112-134
32863294-4 2020 In previous study, we reported that olsalazine sodium significantly reduced the serum urate levels, and the anti-hyperuricemic activity linked with inhibiting urate formation by reducing the activity of xanthine oxidoreductase. Uric Acid 159-164 xanthine dehydrogenase Rattus norvegicus 203-226
33082244-1 2020 OBJECTIVE: Weight loss diets may reduce serum urate (SU) by lowering insulin resistance while providing cardiometabolic benefits, something urate-lowering drugs have not shown in trials. Uric Acid 46-51 insulin Homo sapiens 69-76
32852729-11 2020 Simply linear regression analysis indicated serum myonectin was negatively correlated body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, uric acid, and ACR, and positively correlated with glomerular filtration rate, insulin treatment. Uric Acid 198-207 erythroferrone Homo sapiens 50-59
32086945-0 2020 Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease. Uric Acid 22-31 aldo-keto reductase family 1 member B Homo sapiens 36-52
32946852-9 2020 Simply linear regression analysis indicated a negative association between serum Metrnl and duration of disease, body mass index (BMI), HbA1c, blood urea nitrogen, creatinine, uricacid, ACR, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers treatment. Uric Acid 176-184 meteorin like, glial cell differentiation regulator Homo sapiens 81-87
32952646-9 2020 The concentrations of CD68 and TGF-beta1 in the study group positively correlated with the renal injury indexes, such as blood urea nitrogen (BUN), serum creatinine (SCR), uric acid (UA) and the 24-h urinary protein quantity (P<0.05). Uric Acid 172-181 CD68 molecule Homo sapiens 22-26
32952646-9 2020 The concentrations of CD68 and TGF-beta1 in the study group positively correlated with the renal injury indexes, such as blood urea nitrogen (BUN), serum creatinine (SCR), uric acid (UA) and the 24-h urinary protein quantity (P<0.05). Uric Acid 172-181 transforming growth factor beta 1 Homo sapiens 31-40
32574739-2 2020 Uric acid production can be lowered by xanthine oxidase (XO) inhibitors. Uric Acid 0-9 xanthine dehydrogenase Mus musculus 39-55
32506648-8 2020 Results showed that UA exposure inhibited cell viability and increased IL-1beta and IL-18 generation in a concentration dependent manner. Uric Acid 20-22 interleukin 1 alpha Homo sapiens 71-79
32506648-8 2020 Results showed that UA exposure inhibited cell viability and increased IL-1beta and IL-18 generation in a concentration dependent manner. Uric Acid 20-22 interleukin 18 Homo sapiens 84-89
32086945-6 2020 Lastly, we demonstrated the therapeutic potential of pharmacological AR inhibition against alcohol-induced hepatic injury in experimental ALD CONCLUSIONS: Our data demonstrate that hepatic AR upregulation, and consequent elevation in fructose, sorbitol and/or uric acid, are important factors contributing to alcohol-induced steatosis, ER stress, apoptosis and liver injury in both experimental and human ALD. Uric Acid 260-269 aldo-keto reductase family 1 member B Homo sapiens 69-71
32086945-6 2020 Lastly, we demonstrated the therapeutic potential of pharmacological AR inhibition against alcohol-induced hepatic injury in experimental ALD CONCLUSIONS: Our data demonstrate that hepatic AR upregulation, and consequent elevation in fructose, sorbitol and/or uric acid, are important factors contributing to alcohol-induced steatosis, ER stress, apoptosis and liver injury in both experimental and human ALD. Uric Acid 260-269 aldo-keto reductase family 1 member B Homo sapiens 189-191
33057990-8 2020 After immobilization of uricase, UOx, on PTH/MWCNT/GCE, the biosensor was successfully applied to the determination of uric acid, with fast response ( 7 s), good sensitivity (450 muA cm-2 mM-1, wide linear range (0.48-279 muM) and low detection limit (58.9 nM), better than in the literature and than with PTH prepared in aqueous solution. Uric Acid 119-128 urate oxidase (pseudogene) Homo sapiens 24-31
33678310-6 2020 The nucleotide-binding oligomerization domain leucine-rich repeats and pyrin domain-containing protein 3 inflammasome plays a pivotal role in the inflammatory response to MSU crystals, and interleukin 1beta is the key cytokine mediating the inflammatory cascade. Uric Acid 171-174 interleukin 1 beta Homo sapiens 189-206
33120985-9 2020 Thus, NAD+ is a significant source of adenosine and UA in the airways in mouse models of allergic airway disease, and the capacity for their generation from NAD+ is augmented by CD38, a major NADase with high affinity for NAD+. Uric Acid 52-54 CD38 antigen Mus musculus 178-182
33087043-0 2020 The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis. Uric Acid 70-75 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 49-54
33087043-0 2020 The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis. Uric Acid 70-75 solute carrier family 2 member 9 Homo sapiens 59-65
33087043-1 2020 BACKGROUND: Replication studies showed conflicting effects of ABCG2 and SLC2A9 polymorphisms on gout and serum urate. Uric Acid 111-116 solute carrier family 2 member 9 Homo sapiens 72-78
32861775-5 2020 A database search indicated that this gene is the human cytosolic 5"-nucleotidase II gene (cN-II) homolog in Bombyx, which mediates the conversion of inosine monophosphate (IMP) to inosine, a precursor of uric acid. Uric Acid 205-214 5'-nucleotidase, cytosolic II Homo sapiens 91-96
32861775-7 2020 Moreover, the translucent phenotype of, and decreased uric acid content in the larval integument caused by the mutations in the Bm-cN-II gene were rescued by oral administration of inosine. Uric Acid 54-63 5'-nucleotidase, cytosolic II Homo sapiens 131-136
32890737-0 2020 Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors. Uric Acid 0-9 solute carrier family 5 member 2 Homo sapiens 116-121
32890737-7 2020 Interestingly, sodium-glucose cotransporter 2 (SGLT2) inhibitors induce a state of nutrient deprivation that includes activation of sirtuin-1, suppression of xanthine oxidase and lowering of serum uric acid. Uric Acid 197-206 solute carrier family 5 member 2 Homo sapiens 15-45
32890737-7 2020 Interestingly, sodium-glucose cotransporter 2 (SGLT2) inhibitors induce a state of nutrient deprivation that includes activation of sirtuin-1, suppression of xanthine oxidase and lowering of serum uric acid. Uric Acid 197-206 solute carrier family 5 member 2 Homo sapiens 47-52
32890737-8 2020 The intermediary role of sirtuin-1 in both uric acid-lowering and cardioprotection may explain why, in mediation analyses of large-scale cardiovascular trials, the effect of SGLT2 inhibitors to decrease serum uric acid is a major predictor of the ability of these drugs to reduce serious heart failure events. Uric Acid 43-52 sirtuin 1 Homo sapiens 25-34
32890737-8 2020 The intermediary role of sirtuin-1 in both uric acid-lowering and cardioprotection may explain why, in mediation analyses of large-scale cardiovascular trials, the effect of SGLT2 inhibitors to decrease serum uric acid is a major predictor of the ability of these drugs to reduce serious heart failure events. Uric Acid 43-52 solute carrier family 5 member 2 Homo sapiens 174-179
32890737-8 2020 The intermediary role of sirtuin-1 in both uric acid-lowering and cardioprotection may explain why, in mediation analyses of large-scale cardiovascular trials, the effect of SGLT2 inhibitors to decrease serum uric acid is a major predictor of the ability of these drugs to reduce serious heart failure events. Uric Acid 209-218 sirtuin 1 Homo sapiens 25-34
32890737-8 2020 The intermediary role of sirtuin-1 in both uric acid-lowering and cardioprotection may explain why, in mediation analyses of large-scale cardiovascular trials, the effect of SGLT2 inhibitors to decrease serum uric acid is a major predictor of the ability of these drugs to reduce serious heart failure events. Uric Acid 209-218 solute carrier family 5 member 2 Homo sapiens 174-179
32949793-7 2020 Moreover, severe low serum albumin level (aOR = 2.43, P = 0.046) and abnormal uric acid (aOR = 2.19, P = 0.033) were positively correlated to the incidence of FGR, while pre-pregnancy BMI (aOR = 0.39, P = 0.001) and anemia (aOR = 0.33, P = 0.001) showed negative correlation. Uric Acid 78-87 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 159-162
33350242-12 2020 This study showed that FHT may regulate the renal uric acid transport system through LRRK1 gene, improve the capacity of uric acid excretion, so as to reduce the level of serum uric acid. Uric Acid 50-59 leucine-rich repeat kinase 1 Mus musculus 85-90
32996975-1 2020 In purine metabolism, the xanthine oxidoreductase enzyme converts hypoxanthine (HXN) to xanthine (XN) and XN to uric acid (UA). Uric Acid 112-121 xanthine dehydrogenase Homo sapiens 26-49
32996975-1 2020 In purine metabolism, the xanthine oxidoreductase enzyme converts hypoxanthine (HXN) to xanthine (XN) and XN to uric acid (UA). Uric Acid 123-125 xanthine dehydrogenase Homo sapiens 26-49
33204337-8 2020 Mechanistically, IL-33 was largely released from infiltrated macrophages in inflamed ankle upon MSU stimulation. Uric Acid 96-99 interleukin 33 Mus musculus 17-22
33057990-8 2020 After immobilization of uricase, UOx, on PTH/MWCNT/GCE, the biosensor was successfully applied to the determination of uric acid, with fast response ( 7 s), good sensitivity (450 muA cm-2 mM-1, wide linear range (0.48-279 muM) and low detection limit (58.9 nM), better than in the literature and than with PTH prepared in aqueous solution. Uric Acid 119-128 urate oxidase (pseudogene) Homo sapiens 33-36
33154749-9 2020 Finally, MSU-induced PMN-MDSCs produced higher levels of IL-1beta, which mediated gout inflammatory progression. Uric Acid 9-12 interleukin 1 alpha Homo sapiens 57-65
32780898-7 2020 High-uric acid levels-induced p-STAT3 inhibition and SREBP-1c activation in vivo and in vitro. Uric Acid 5-14 signal transducer and activator of transcription 3 Mus musculus 32-37
32955167-1 2020 OBJECTIVE: To characterize in detail the structural bone changes associated with the deposition of monosodium urate crystals in the first metatarsophalangeal (MTP1) joint in patients with tophaceous gout. Uric Acid 99-115 solute carrier family 40 member 1 Homo sapiens 159-163
32955167-9 2020 The extent of uric acid deposition is positively correlated with the extent of bone loss at the MTP1 joint, highlighting the strong cohesion of inflammation and erosive changes. Uric Acid 14-23 solute carrier family 40 member 1 Homo sapiens 96-100
32794003-0 2020 An electrochemical biosensor based on multi-wall carbon nanotube-modified screen-printed electrode immobilized by uricase for the detection of salivary uric acid. Uric Acid 152-161 urate oxidase (pseudogene) Homo sapiens 114-121
32794003-3 2020 The working electrode was modified with carbon nanotubes followed by uricase for UA detection with excellent selectivity. Uric Acid 81-83 urate oxidase (pseudogene) Homo sapiens 69-76
32794003-7 2020 Graphical abstract A disposable uric acid biosensor modified with carbon nanotubes followed by uricase was fabricated on flexible PET and applied for the monitoring of salivary uric acid in human saliva. Uric Acid 32-41 urate oxidase (pseudogene) Homo sapiens 95-102
32794003-7 2020 Graphical abstract A disposable uric acid biosensor modified with carbon nanotubes followed by uricase was fabricated on flexible PET and applied for the monitoring of salivary uric acid in human saliva. Uric Acid 177-186 urate oxidase (pseudogene) Homo sapiens 95-102
33117389-9 2020 In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury. Uric Acid 22-31 NLR family, pyrin domain containing 3 Mus musculus 65-116
33117389-9 2020 In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury. Uric Acid 22-31 NLR family, pyrin domain containing 3 Mus musculus 118-123
33004785-0 2020 Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients. Uric Acid 69-78 solute carrier family 5 member 2 Homo sapiens 0-30
33004785-2 2020 SGLT2 inhibitors ameliorate cardiovascular morbidity and mortality as well as kidney disease progression by reducing body weight (BW), blood pressure (BP), visceral adiposity, albuminuria, and serum uric acid and blood glucose levels. Uric Acid 199-208 solute carrier family 5 member 2 Homo sapiens 0-5
33004785-10 2020 CONCLUSIONS Serum uric acid levels were immediately decreased owing to the administration of SGLT2 inhibitor, but BP, blood glucose, and serum lipid levels were unchanged. Uric Acid 18-27 solute carrier family 5 member 2 Homo sapiens 93-98
32807664-8 2020 Transporter inhibition study highlighted that GLUT9 strongly and MRP4 intermediately contribute to the sinusoidal efflux of UA with minor contribution of NPT1/4. Uric Acid 124-126 solute carrier family 2 member 9 Homo sapiens 46-51
32807664-8 2020 Transporter inhibition study highlighted that GLUT9 strongly and MRP4 intermediately contribute to the sinusoidal efflux of UA with minor contribution of NPT1/4. Uric Acid 124-126 ATP binding cassette subfamily C member 4 Homo sapiens 65-69
32780898-7 2020 High-uric acid levels-induced p-STAT3 inhibition and SREBP-1c activation in vivo and in vitro. Uric Acid 5-14 sterol regulatory element binding transcription factor 1 Mus musculus 53-61
32780898-8 2020 Moreover, LPCAT3-knockdown significantly attenuated uric acid-induced p-STAT3 inhibition, SREBP-1c activation, and lipid metabolic disorders in L02 cells. Uric Acid 52-61 lysophosphatidylcholine acyltransferase 3 Homo sapiens 10-16
32780898-8 2020 Moreover, LPCAT3-knockdown significantly attenuated uric acid-induced p-STAT3 inhibition, SREBP-1c activation, and lipid metabolic disorders in L02 cells. Uric Acid 52-61 signal transducer and activator of transcription 3 Homo sapiens 72-77
32780898-8 2020 Moreover, LPCAT3-knockdown significantly attenuated uric acid-induced p-STAT3 inhibition, SREBP-1c activation, and lipid metabolic disorders in L02 cells. Uric Acid 52-61 sterol regulatory element binding transcription factor 1 Homo sapiens 90-98
32780898-9 2020 In conclusion, uric acid induces lipid metabolic disturbances through LPCAT3-mediated p-STAT3 inhibition and SREBP-1c activation. Uric Acid 15-24 lysophosphatidylcholine acyltransferase 3 Homo sapiens 70-76
32780898-9 2020 In conclusion, uric acid induces lipid metabolic disturbances through LPCAT3-mediated p-STAT3 inhibition and SREBP-1c activation. Uric Acid 15-24 signal transducer and activator of transcription 3 Homo sapiens 88-93
32780898-9 2020 In conclusion, uric acid induces lipid metabolic disturbances through LPCAT3-mediated p-STAT3 inhibition and SREBP-1c activation. Uric Acid 15-24 sterol regulatory element binding transcription factor 1 Homo sapiens 109-117
33000578-7 2020 RESULTS: Compared with the blank group, the expression levels of NF-kappaB, IL-1beta, IL-8, and TNF-alpha were increased significantly at different timepoints in the in vitro model of synovial cell inflammatory responses induced by sodium urate, and in the in vivo model of gouty arthritis. Uric Acid 232-244 tumor necrosis factor Rattus norvegicus 96-105
32772309-1 2020 INTRODUCTION: Hyperuricemia is related to health issues among children and adolescents, once the uric acid concentration is associated with metabolic syndrome, hypertension, insulin resistance, obesity, and dyslipidemia. Uric Acid 97-106 insulin Homo sapiens 174-181
33000578-8 2020 Compared with the model group, the expressions of NF-kappaB, IL-1beta, IL-8, and TNF-alpha in synovial cells induced by sodium urate were decreased in the different Xixiancao (Herba Siegesbeckiae Orientalis) dose groups and the colchicine group. Uric Acid 120-132 interleukin 1 alpha Rattus norvegicus 61-69
33000578-8 2020 Compared with the model group, the expressions of NF-kappaB, IL-1beta, IL-8, and TNF-alpha in synovial cells induced by sodium urate were decreased in the different Xixiancao (Herba Siegesbeckiae Orientalis) dose groups and the colchicine group. Uric Acid 120-132 tumor necrosis factor Rattus norvegicus 81-90
32323149-0 2020 Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. Uric Acid 10-19 elastin Homo sapiens 110-117
33002030-8 2020 RESULTS: Injection of MSU crystals produced a robust inflammatory response with increased ankle swelling, NF-kappaB activity, and synovial infiltration by macrophages and neutrophils. Uric Acid 22-25 nuclear factor kappa B subunit 1 Homo sapiens 106-115
33002030-10 2020 Furthermore, IL-1beta was decreased at the site of MSU crystal injection, TLR2 expression on peripheral neutrophils was downregulated, and expression of CXCL1 in serum was suppressed with low and moderate-intensity exercise. Uric Acid 51-54 interleukin 1 alpha Homo sapiens 13-21
33002030-13 2020 CONCLUSIONS: Regular, moderate physical activity can produce a quantifiable anti-inflammatory effect capable of partially mitigating the pathologic response induced by intra-articular MSU crystals by downregulating TLR2 expression on circulating neutrophils and suppressing systemic CXCL1. Uric Acid 184-187 toll like receptor 2 Homo sapiens 215-219
33002030-13 2020 CONCLUSIONS: Regular, moderate physical activity can produce a quantifiable anti-inflammatory effect capable of partially mitigating the pathologic response induced by intra-articular MSU crystals by downregulating TLR2 expression on circulating neutrophils and suppressing systemic CXCL1. Uric Acid 184-187 C-X-C motif chemokine ligand 1 Homo sapiens 283-288
32623939-6 2020 In parallel, uric acid in addition to its pro-inflammatory effects, aggravates insulin resistance and hyperglycaemia, which worsen the process. Uric Acid 13-22 insulin Homo sapiens 79-86
32323149-0 2020 Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis. Uric Acid 10-19 mitogen-activated protein kinase 3 Homo sapiens 156-162
32595041-7 2020 A kinetic study revealed that the induction of Eps8 expression by MSU crystals occurred before NLRP3, p46/p33 caspase-1, and mature IL-1beta in RAW 264.7 cells. Uric Acid 66-69 epidermal growth factor receptor pathway substrate 8 Mus musculus 47-51
33062074-4 2020 The minor allele (A) of the TGFBR3 rs1805110 polymorphism was associated with increased hemoglobin, hematocrit, reticulocyte counts, total cholesterol, low-density lipoprotein, uric acid, and endothelin levels, as well as decreased platelet distribution width (PDW) and the occurrence of bone alterations. Uric Acid 177-186 transforming growth factor beta receptor 3 Homo sapiens 28-34
33062010-8 2020 Meanwhile, DLE regulated the levels of uric acid transporters mRNA transcripts, including mouse organic anion transporter 1 (mOAT1), organic anion transporter 3 (mOAT3), urate transporter 1 (mURAT1), and glucose transporter 9 (mGLUT9) in the kidney (P < 0.05), suggesting that DLE promoted uric acid metabolism. Uric Acid 39-48 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 96-123
33062010-8 2020 Meanwhile, DLE regulated the levels of uric acid transporters mRNA transcripts, including mouse organic anion transporter 1 (mOAT1), organic anion transporter 3 (mOAT3), urate transporter 1 (mURAT1), and glucose transporter 9 (mGLUT9) in the kidney (P < 0.05), suggesting that DLE promoted uric acid metabolism. Uric Acid 39-48 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 125-130
33062010-8 2020 Meanwhile, DLE regulated the levels of uric acid transporters mRNA transcripts, including mouse organic anion transporter 1 (mOAT1), organic anion transporter 3 (mOAT3), urate transporter 1 (mURAT1), and glucose transporter 9 (mGLUT9) in the kidney (P < 0.05), suggesting that DLE promoted uric acid metabolism. Uric Acid 39-48 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 191-197
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-42
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 44-49
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 66-98
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 100-104
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 0-20
33003314-1 2020 ATP-binding cassette sub-family G member 2 (ABCG2), also known as breast cancer resistance protein (BCRP), is one of the key efflux ATP-binding cassette (ABC) transporters of xenobiotics, their metabolites and endogenous compounds such as urate. Uric Acid 239-244 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 44-47
32595041-0 2020 EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. Uric Acid 81-97 epidermal growth factor receptor pathway substrate 8 Mus musculus 0-4
32595041-0 2020 EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. Uric Acid 81-97 NLR family, pyrin domain containing 3 Mus musculus 18-23
32595041-0 2020 EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. Uric Acid 81-97 caspase 1 Mus musculus 49-58
32595041-9 2020 Silencing Eps8 had no effect on the basal expression of p46/p33 caspase-1 and NLRP3, but nearly abolished MSU crystal-induced NLRP3 expression and caspase-1 activation. Uric Acid 106-109 epidermal growth factor receptor pathway substrate 8 Mus musculus 10-14
32595041-9 2020 Silencing Eps8 had no effect on the basal expression of p46/p33 caspase-1 and NLRP3, but nearly abolished MSU crystal-induced NLRP3 expression and caspase-1 activation. Uric Acid 106-109 NLR family, pyrin domain containing 3 Mus musculus 126-131
32595041-9 2020 Silencing Eps8 had no effect on the basal expression of p46/p33 caspase-1 and NLRP3, but nearly abolished MSU crystal-induced NLRP3 expression and caspase-1 activation. Uric Acid 106-109 caspase 1 Mus musculus 147-156
32595041-10 2020 Furthermore, MSU crystals induced Eps8-pro-caspase-1 complex formation and Eps8 formed a stable complex with p33 caspase-1, but not with NLRP3. Uric Acid 13-16 epidermal growth factor receptor pathway substrate 8 Mus musculus 34-38
32595041-10 2020 Furthermore, MSU crystals induced Eps8-pro-caspase-1 complex formation and Eps8 formed a stable complex with p33 caspase-1, but not with NLRP3. Uric Acid 13-16 caspase 1 Mus musculus 43-52
32595041-10 2020 Furthermore, MSU crystals induced Eps8-pro-caspase-1 complex formation and Eps8 formed a stable complex with p33 caspase-1, but not with NLRP3. Uric Acid 13-16 caspase 1 Mus musculus 113-122
32917279-12 2020 MTP1 joints and patella tendons showed only definite MSU depositions. Uric Acid 53-56 solute carrier family 40 member 1 Homo sapiens 0-4
32957872-9 2021 CONCLUSION: This is the first study that shows uric acid, folic acid, glutathione and ascorbic acid provide protection against the generation of toxic met-myoglobin and might be used therapeutically to modify the blood conditions in order to prevent the progression of human disorders associated with myoglobin dysfuntion. Uric Acid 47-56 myoglobin Homo sapiens 301-310
32559693-7 2020 The recoveries of DA and UA in bovine serum samples at MWCNT-COOH/SWCNT-OH/GCE were in the range 96.18-105.02%, and relative standard deviations (RSDs) were 3.34-7.27%. Uric Acid 25-27 aminomethyltransferase Homo sapiens 66-78
32960786-0 2020 Prothrombotic effects of high uric acid in mice via activation of MEF2C-dependent NF-kappaB pathway by upregulating let-7c. Uric Acid 30-39 myocyte enhancer factor 2C Mus musculus 66-71
32960786-0 2020 Prothrombotic effects of high uric acid in mice via activation of MEF2C-dependent NF-kappaB pathway by upregulating let-7c. Uric Acid 30-39 microRNA let-7c Homo sapiens 116-122
32960786-4 2020 Analysis indicated that let-7c was upregulated in hyperuricemia patients as well as in mice and human umbilical vein endothelial cells treated with high uric acid. Uric Acid 153-162 microRNA let-7c Homo sapiens 24-30
32960786-5 2020 Furthermore, high uric acid inhibited myocyte enhancer factor-2C, but activated nuclear factor-kappa B pathway in human umbilical vein endothelial cells. Uric Acid 18-27 myocyte enhancer factor 2C Homo sapiens 38-64
32960786-10 2020 To sum up, our results uncovered the pro-thrombotic effect of high uric acid in mice by activating myocyte enhancer factor-2C-dependent nuclear factor-kappa B pathway via let-7c upregulation. Uric Acid 67-76 myocyte enhancer factor 2C Mus musculus 99-125
32960786-10 2020 To sum up, our results uncovered the pro-thrombotic effect of high uric acid in mice by activating myocyte enhancer factor-2C-dependent nuclear factor-kappa B pathway via let-7c upregulation. Uric Acid 67-76 microRNA let-7c Homo sapiens 171-177
32957872-0 2021 Protective Potential of Uric Acid, Folic Acid, Glutathione and Ascorbic Acid against the Formation of Toxic Met-Myoglobin. Uric Acid 24-33 myoglobin Homo sapiens 112-121
32957872-6 2021 Spectroscopic analysis was used to identify the protective potential of uric acid, folic acid, glutathione and ascorbic acid against the formation of met-myoglobin. Uric Acid 72-81 myoglobin Homo sapiens 154-163
32957872-7 2021 RESULTS: The novel data of this study showed that H2O2 induced extensive damage of myoglobin but the treatment with uric acid, folic acid, glutathione or ascorbic acid provides protection of myoglobin against H2O2 induced oxidative damaged. Uric Acid 116-125 myoglobin Homo sapiens 191-200
32957872-9 2021 CONCLUSION: This is the first study that shows uric acid, folic acid, glutathione and ascorbic acid provide protection against the generation of toxic met-myoglobin and might be used therapeutically to modify the blood conditions in order to prevent the progression of human disorders associated with myoglobin dysfuntion. Uric Acid 47-56 myoglobin Homo sapiens 155-164
32917279-14 2020 MTP1 joints and patella tendons exclusively showed definite MSU depositions. Uric Acid 60-63 solute carrier family 40 member 1 Homo sapiens 0-4
32885795-10 2020 UA inhibited the PI3K/AKT pathway, an effect reversed by ICA treatment. Uric Acid 0-2 thymoma viral proto-oncogene 1 Mus musculus 22-25
32911634-3 2020 Xanthine oxidoreductase (XOR) activities produce uric acid, as well as reactive oxygen and nitrogen species, which all may be relevant to such equilibrium. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 0-23
32911634-3 2020 Xanthine oxidoreductase (XOR) activities produce uric acid, as well as reactive oxygen and nitrogen species, which all may be relevant to such equilibrium. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 25-28
32885795-11 2020 The specific PI3K/Akt inhibitor LY294002, however, reversed these effects of ICA on UA-treated Min6 cells. Uric Acid 84-86 thymoma viral proto-oncogene 1 Mus musculus 18-21
32885795-9 2020 UA decreased Min6 cell viability, enhanced cell apoptosis and levels of cleaved caspase-3, and reduced pro-caspase3 levels and insulin secretion, with all of these effects reversed by ICA in a dose-dependent manner. Uric Acid 0-2 caspase 3 Mus musculus 80-89
32885795-9 2020 UA decreased Min6 cell viability, enhanced cell apoptosis and levels of cleaved caspase-3, and reduced pro-caspase3 levels and insulin secretion, with all of these effects reversed by ICA in a dose-dependent manner. Uric Acid 0-2 caspase 3 Mus musculus 107-115
32705194-4 2020 In cell models of RAW 264.7 and THP-1-derived macrophages, decreased expression of lncRNA-MM2P was observed in lipopolysaccharide- and MSU-treated macrophages, which was accompanied with obvious inflammatory responses. Uric Acid 135-138 GLI family zinc finger 2 Homo sapiens 32-37
32701600-9 2020 Studies in humans identified a urate-lowering effect by SGLT2 inhibition which is possibly mediated by urate transporter 1 (URAT1) and/or glucose transporter member 9 in the proximal tubule. Uric Acid 31-36 solute carrier family 5 member 2 Homo sapiens 56-61
32701600-9 2020 Studies in humans identified a urate-lowering effect by SGLT2 inhibition which is possibly mediated by urate transporter 1 (URAT1) and/or glucose transporter member 9 in the proximal tubule. Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 103-122
32701600-9 2020 Studies in humans identified a urate-lowering effect by SGLT2 inhibition which is possibly mediated by urate transporter 1 (URAT1) and/or glucose transporter member 9 in the proximal tubule. Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 124-129
32701600-11 2020 SUMMARY: Cardiorenal effects of SGLT2 inhibition might involve, in addition to direct effects on glucose homeostasis, effects on NHE3, phosphate, urate, and magnesium homeostasis. Uric Acid 146-151 solute carrier family 5 member 2 Homo sapiens 32-37
32434129-3 2020 It is well-known that uric acid is an organic compound and the water-soluble final product of purine catabolism, which is catalysed by xanthine oxidoreductase and excreted by kidneys. Uric Acid 22-31 xanthine dehydrogenase Homo sapiens 135-158
32644154-12 2020 Uric acid was higher in participants with an SSB intake >=7 servings/wk, compared with those with an intake <1 serving/wk (P < 0.001). Uric Acid 0-9 small RNA binding exonuclease protection factor La Homo sapiens 45-48
32811191-11 2020 The hypouricemic efficacy of Sco was due to promoting the excretion of uric acid via modulating the alteration of gene expression levels of renal uric acid transporter (URAT1), glucose transporter (GLUT9) and organic anion transporter 1 (OAT1). Uric Acid 146-155 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 169-174
32811191-12 2020 Sco-Ms could not only restore the dysregulation of URAT1, GLUT9 and OAT1 more effectively, but also down-regulate the activity of hepatic xanthine oxidase (XOD) to inhibit the production of uric acid. Uric Acid 190-199 xanthine dehydrogenase Mus musculus 138-154
32705194-5 2020 Using small interfering RNA to knockdown lncRNA-MM2P led to the upregulation of MSU-mediated inflammatory responses, both in RAW 264.7 and THP-1-derived macrophages. Uric Acid 80-83 GLI family zinc finger 2 Homo sapiens 139-144
31998961-13 2020 CONCLUSION: In contrast to other serum urate-raising variants, the ABCG2 rs2231142 T-allele is strongly associated with early-onset gout. Uric Acid 39-44 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 67-72
32628957-10 2020 It can be concluded that reducing uric acid level through xanthine oxidase inhibition and suppression of the inflammatory signaling cascade; IL-6/JAK1/STAT3; by cinnamaldehyde could be a novel and promising therapeutic approach against BPH. Uric Acid 34-43 interleukin 6 Rattus norvegicus 141-145
33229764-5 2020 Only serum SPON2 levels were correlated with serum uric acid and triglyceride levels in patients with glomerular disease. Uric Acid 51-60 spondin 2 Homo sapiens 11-16
32720081-3 2020 Pegloticase, a recombinant uricase, converts uric acid to allantoin, a readily excreted molecule. Uric Acid 45-54 urate oxidase (pseudogene) Homo sapiens 27-34
32628957-10 2020 It can be concluded that reducing uric acid level through xanthine oxidase inhibition and suppression of the inflammatory signaling cascade; IL-6/JAK1/STAT3; by cinnamaldehyde could be a novel and promising therapeutic approach against BPH. Uric Acid 34-43 signal transducer and activator of transcription 3 Rattus norvegicus 151-156
32628957-10 2020 It can be concluded that reducing uric acid level through xanthine oxidase inhibition and suppression of the inflammatory signaling cascade; IL-6/JAK1/STAT3; by cinnamaldehyde could be a novel and promising therapeutic approach against BPH. Uric Acid 34-43 Janus kinase 1 Rattus norvegicus 146-150
32786873-4 2020 Pharmacological investigation of the pure compounds in the cellular model of hyperuricemia indicated that 12 compounds could promote the excretion of uric acid at 10 mug/mL, and compounds 3, 4, 5, and 21 had better effects than that of benzbromarone, a famous uricosuric drug. Uric Acid 150-159 thrombopoietin Mus musculus 170-172
33553022-0 2020 Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Uric Acid 150-159 insulin Homo sapiens 10-19
33553022-5 2020 Results: C-peptide secretors had shorter diabetes duration (5.1 vs. 16 years; p < 0,001), lower resistin (4.53 vs. 4.93 mg/mL p = 0.045), and higher uric acid (259 vs 238 mumol/L, p = 0.048) level than T1DM patients with no detectable C-peptide levels, while no differences in routine anthropometric and laboratory variables, including HbA1c, were observed. Uric Acid 149-158 insulin Homo sapiens 9-18
33553022-7 2020 Conclusion: The results of our study revealed that patients with detectable C-peptide had lower resistin and higher uric acid level compared to patients with undetectable C-peptide. Uric Acid 116-125 insulin Homo sapiens 76-85
32847529-1 2020 BACKGROUND: Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by a pathogenic variant in UMOD (ADTKD-UMOD) is a rare group of diseases characterized by hyperuricaemia with decreased urinary excretion of urate, gout and progressive chronic kidney disease. Uric Acid 221-226 uromodulin Homo sapiens 107-111
32847529-1 2020 BACKGROUND: Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by a pathogenic variant in UMOD (ADTKD-UMOD) is a rare group of diseases characterized by hyperuricaemia with decreased urinary excretion of urate, gout and progressive chronic kidney disease. Uric Acid 221-226 uromodulin Homo sapiens 113-123
32854398-0 2020 Fat-Free Mass Is Better Related to Serum Uric Acid Than Metabolic Homeostasis in Prader-Willi Syndrome. Uric Acid 41-50 FAT atypical cadherin 1 Homo sapiens 0-3
32807060-0 2021 Serum Uric Acid and Progression of Autosomal Dominant Polycystic Kidney Disease: Results from the HALT PKD Trials. Uric Acid 6-15 protein kinase D1 Homo sapiens 103-106
32825165-0 2020 Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance. Uric Acid 0-9 insulin Homo sapiens 65-72
32825165-2 2020 Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Uric Acid 0-9 insulin Homo sapiens 35-42
32825165-2 2020 Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Uric Acid 0-9 insulin Homo sapiens 71-78
32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Uric Acid 75-84 gasdermin D Homo sapiens 168-179
32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Uric Acid 75-84 interleukin 1 beta Homo sapiens 248-265
32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Uric Acid 75-84 interleukin 18 Homo sapiens 267-281
32690690-0 2020 Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Uric Acid 38-43 solute carrier family 2 (facilitated glucose transporter), member 12 Mus musculus 25-32
32850909-0 2020 miR-214 Protects Against Uric Acid-Induced Endothelial Cell Apoptosis. Uric Acid 25-34 microRNA 214 Homo sapiens 0-7
32850909-3 2020 This study was to investigate the role of miR-214 in UA-induced endothelial cell apoptosis and the underlying mechanism. Uric Acid 53-55 microRNA 214 Homo sapiens 42-49
32850909-8 2020 In the MAECs, UA treatment strikingly increased apoptosis as shown by the upregulation of BAX and cleaved Caspase-3 and the increased number of apoptotic cells. Uric Acid 14-16 BCL2 associated X, apoptosis regulator Homo sapiens 90-93
32850909-8 2020 In the MAECs, UA treatment strikingly increased apoptosis as shown by the upregulation of BAX and cleaved Caspase-3 and the increased number of apoptotic cells. Uric Acid 14-16 caspase 3 Homo sapiens 106-115
32850909-11 2020 The inhibition of COX-2 markedly ameliorated UA-induced apoptotic response and PGE2 production in MAECs. Uric Acid 45-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-23
32850909-13 2020 Conclusion: We concluded that miR-214 could alleviate UA-induced MAEC apoptosis possibly by inhibiting the COX-2/PGE2 cascade. Uric Acid 54-56 microRNA 214 Homo sapiens 30-37
32850909-13 2020 Conclusion: We concluded that miR-214 could alleviate UA-induced MAEC apoptosis possibly by inhibiting the COX-2/PGE2 cascade. Uric Acid 54-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 107-112
32759678-6 2020 The synergistic effect of Faradaic redox couple species of Zn-Co-S BHS and unique conductive network of CNTs exhibited excellent electrochemical catalytic ability towards the glucose electro-oxidation, which revealed linear range from 5 to 100 muM with high sensitivity of 2734.4 muA mM-1 cm-2, excellent detection limit of 2.98 muM, and great selectivity in the presence of dopamine, uric acid, ascorbic acid, and fructose. Uric Acid 385-394 Mix1 homeobox-like 1 (Xenopus laevis) Mus musculus 284-293
32454120-10 2020 In the hyperuricemia mouse model, Uox-HSA loaded in PEG-PAEU-ABP hydrogels exhibited a substantially extended period of uric acid-lowering efficacy. Uric Acid 120-129 urate oxidase Mus musculus 34-37
32454120-10 2020 In the hyperuricemia mouse model, Uox-HSA loaded in PEG-PAEU-ABP hydrogels exhibited a substantially extended period of uric acid-lowering efficacy. Uric Acid 120-129 amine oxidase, copper-containing 1 Mus musculus 61-64
32784787-6 2020 The GCE/N-rGO-Au-based sensor operated in a wide linear range of DA (3-100 microM), AA (550-1500 microM), and UA (20-1000 microM) concentrations with a detection limit of 2.4, 58, and 8.7 microM, respectively, and exhibited satisfactory peak potential separation values of 0.34 V (AA-DA), 0.20 V, (DA-UA) and 0.54 V (AA-UA). Uric Acid 110-112 aminomethyltransferase Homo sapiens 4-7
32690690-0 2020 Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Uric Acid 38-43 solute carrier family 2 (facilitated glucose transporter), member 12 Mus musculus 18-24
32690690-4 2020 As GLUT12 belongs to the same protein family as a well-recognized urate transporter GLUT9, we hypothesized that GLUT12 mediates membrane transport of urate. Uric Acid 66-71 solute carrier family 2 (facilitated glucose transporter), member 12 Mus musculus 3-9
32690690-4 2020 As GLUT12 belongs to the same protein family as a well-recognized urate transporter GLUT9, we hypothesized that GLUT12 mediates membrane transport of urate. Uric Acid 66-71 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 84-89
32690690-4 2020 As GLUT12 belongs to the same protein family as a well-recognized urate transporter GLUT9, we hypothesized that GLUT12 mediates membrane transport of urate. Uric Acid 66-71 solute carrier family 2 (facilitated glucose transporter), member 12 Mus musculus 112-118
32690690-6 2020 Our results revealed that GLUT12 acts as a physiological urate transporter and its dysfunction elevates the blood urate concentration. Uric Acid 57-62 solute carrier family 2 (facilitated glucose transporter), member 12 Mus musculus 26-32
32432414-2 2020 Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species. Uric Acid 105-114 xanthine dehydrogenase Homo sapiens 0-23
32424988-8 2020 MPO correlated with uric acid (r = 0.26; P = 0.016). Uric Acid 20-29 myeloperoxidase Homo sapiens 0-3
32601305-3 2020 Upregulation of ACOD1 expression occurs in activated immune cells (e.g., macrophages and monocytes) in response to pathogen infection (e.g., bacteria and viruses), pathogen-associated molecular pattern molecules (e.g., LPS), cytokines (e.g., TNF and IFNs), and damage-associated molecular patterns (e.g., monosodium urate). Uric Acid 316-321 aconitate decarboxylase 1 Homo sapiens 16-21
32107664-12 2020 This might also explain the reported reduced urinary uric acid excretion in Filipinos compared with Caucasians.Key Points The Filipinos have the highest prevalence of the gout-associated risk allele (T) of the rs2231142 G>T in ABCG2. Uric Acid 53-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 228-233
32424988-12 2020 CONCLUSIONS: In HFpEF, MPO-dependent oxidative stress reflected by uric acid and calprotectin is increased, and SDMA is associated with diastolic dysfunction and uric acid with outcome. Uric Acid 67-76 myeloperoxidase Homo sapiens 23-26
32432414-2 2020 Xanthine oxidoreductase (XOR), the rate-limiting enzyme of purine metabolism, plays an important role in uric acid production and generates reactive oxygen species. Uric Acid 105-114 xanthine dehydrogenase Homo sapiens 25-28
32329387-8 2020 A promising strategy for treatment is the use of uricosuric agents that inhibit transporters (e.g. URAT1, URATv1/GLUT9, OAT10) which reabsorb urate from the urine. Uric Acid 142-147 solute carrier family 22 member 12 Homo sapiens 99-104
32329387-8 2020 A promising strategy for treatment is the use of uricosuric agents that inhibit transporters (e.g. URAT1, URATv1/GLUT9, OAT10) which reabsorb urate from the urine. Uric Acid 142-147 solute carrier family 2 member 9 Homo sapiens 106-112
32329387-8 2020 A promising strategy for treatment is the use of uricosuric agents that inhibit transporters (e.g. URAT1, URATv1/GLUT9, OAT10) which reabsorb urate from the urine. Uric Acid 142-147 solute carrier family 2 member 9 Homo sapiens 113-118
32329387-8 2020 A promising strategy for treatment is the use of uricosuric agents that inhibit transporters (e.g. URAT1, URATv1/GLUT9, OAT10) which reabsorb urate from the urine. Uric Acid 142-147 solute carrier family 22 member 13 Homo sapiens 120-125
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 albumin Mus musculus 10-13
32765680-0 2020 Lipoxin A4 attenuates uric acid-activated, NADPH oxidase-dependent oxidative stress by interfering with translocation of p47phox in human umbilical vein endothelial cells. Uric Acid 22-31 neutrophil cytosolic factor 1 Homo sapiens 121-128
32251019-0 2020 X-ray Dark-Field Radiography: Potential for Visualization of Monosodium Urate Deposition. Uric Acid 61-77 dark Mus musculus 6-10
32558367-0 2020 Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome. Uric Acid 8-17 NLR family, pyrin domain containing 3 Rattus norvegicus 67-72
32558367-1 2020 Uric acid crystal is known to activate the NLRP3 inflammasome and to cause tissue damages, which can result in many diseases, such as gout, chronic renal injury and myocardial damage. Uric Acid 0-9 NLR family, pyrin domain containing 3 Rattus norvegicus 43-48
32251019-1 2020 OBJECTIVE: The aim of this study was to evaluate the potential of x-ray dark-field radiography for the noninvasive detection of monosodium urate (MSU) crystals as a novel diagnostic tool for gout. Uric Acid 128-144 dark Mus musculus 72-76
32251019-1 2020 OBJECTIVE: The aim of this study was to evaluate the potential of x-ray dark-field radiography for the noninvasive detection of monosodium urate (MSU) crystals as a novel diagnostic tool for gout. Uric Acid 146-149 dark Mus musculus 72-76
32251019-6 2020 RESULTS: X-ray dark-field radiography provided a strong signal increase for MSU crystals in a physiological buffer solution compared with conventional attenuation radiography with a contrast-to-noise ratio increase from 0.8 to 19.3. Uric Acid 76-79 dark Mus musculus 15-19
32251019-10 2020 CONCLUSIONS: X-ray dark-field radiography enables the detection of MSU crystals in a mouse-based gout model. Uric Acid 67-70 dark Mus musculus 19-23
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 22-27
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 lysyl oxidase Mus musculus 28-31
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 lysyl oxidase Mus musculus 32-35
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 lysyl oxidase Mus musculus 32-35
32561569-7 2020 Moreover, Alb-creERT2;Glut9 lox/lox mice with hyperuricemia (serum UA of 9-11 mg/dl) showed a suppressed inflammatory response to MSU crystals compared with Glut9 lox/lox controls without hyperuricemia. Uric Acid 130-133 lysyl oxidase Mus musculus 32-35
32407847-8 2020 KEY FINDINGS: The results showed that the TR and/or HES treatment significantly suppressed CCl4 induced rise of urea, uric acid, potassium, and follicle-stimulating hormone levels. Uric Acid 118-127 C-C motif chemokine ligand 4 Rattus norvegicus 91-95
32935805-7 2020 Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). Uric Acid 73-82 hepcidin antimicrobial peptide Homo sapiens 0-8
32935532-3 2020 RESULTS: For metabolically related biomarkers, a 1-SD increase in body fat mass (BFM) was robustly associated with increased fasting insulin, systolic blood pressure, diastolic blood pressure, and urate and decreased high-density lipoprotein cholesterol levels. Uric Acid 197-202 FAT atypical cadherin 1 Homo sapiens 71-74
32935532-5 2020 The effects of body fat on diseases were mediated by extensive intermediate biomarkers, including blood pressure, lipids, glycemic traits, and urate. Uric Acid 143-148 FAT atypical cadherin 1 Homo sapiens 20-23
32345632-5 2020 Biochemical evaluation of numerous ligand candidates revealed that NMT1 motif RNA constructs most tightly bind 8-azaxanthine, xanthine, and uric acid, whereas most other closely related compounds are strongly rejected. Uric Acid 140-149 N-myristoyltransferase 1 Homo sapiens 67-71
32413846-5 2020 The downregulation of Hprt1, a key purine metabolism regulation gene, in the liver was responsible for the elevation of an important purine metabolite, uric acid, in the serum, causing abnormalities in kidney morphology and function and leading to death of neonatal cloned pigs. Uric Acid 152-161 hypoxanthine phosphoribosyltransferase 1 Sus scrofa 22-27
32774151-7 2020 Cyr61 was highly expressed in synovial tissues of gout models, and the expression of Cyr61 protein was also significantly increased in MSU-stimulated FLS cells. Uric Acid 135-138 cellular communication network factor 1 Rattus norvegicus 85-90
32735550-0 2021 Plasma xanthine oxidoreductase activity change over 12 months independently associated with change in serum uric acid level: MedCity21 health examination registry. Uric Acid 108-117 xanthine dehydrogenase Homo sapiens 7-30
32716977-9 2020 In the subgroup analysis of female participants and participants with diabetes and CKD, a significant association was observed between +1 mg/dL of uric acid and NOBP. Uric Acid 147-156 EBNA1 binding protein 2 Homo sapiens 161-165
32716977-10 2020 Higher uric acid concentration at baseline was significantly associated with NOBP on the first use of antihypertensive drug(s). Uric Acid 7-16 EBNA1 binding protein 2 Homo sapiens 77-81
32774151-8 2020 Cyr61 promoted MSU-induced acute inflammation via the NF-kappaB signaling pathway. Uric Acid 15-18 cellular communication network factor 1 Rattus norvegicus 0-5
32452918-2 2020 In the evolutionary process, humans lost uricase, an enzyme that converts uric acid into allantoin, resulting in increased serum uric acid levels that may vary according to dietary ingestion, pathological conditions, and other factors. Uric Acid 74-83 urate oxidase (pseudogene) Homo sapiens 41-48
32677916-1 2020 BACKGROUND: Renal hypouricemia (RHUC) is a genetic disorder caused by mutations in the SLC22A12 gene, which encodes the major uric acid (UA) transporter, URAT1. Uric Acid 126-135 solute carrier family 22 member 12 Homo sapiens 87-95
32677916-1 2020 BACKGROUND: Renal hypouricemia (RHUC) is a genetic disorder caused by mutations in the SLC22A12 gene, which encodes the major uric acid (UA) transporter, URAT1. Uric Acid 126-135 solute carrier family 22 member 12 Homo sapiens 154-159
32677916-1 2020 BACKGROUND: Renal hypouricemia (RHUC) is a genetic disorder caused by mutations in the SLC22A12 gene, which encodes the major uric acid (UA) transporter, URAT1. Uric Acid 137-139 solute carrier family 22 member 12 Homo sapiens 87-95
32677916-1 2020 BACKGROUND: Renal hypouricemia (RHUC) is a genetic disorder caused by mutations in the SLC22A12 gene, which encodes the major uric acid (UA) transporter, URAT1. Uric Acid 137-139 solute carrier family 22 member 12 Homo sapiens 154-159
32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 NLR family pyrin domain containing 3 Homo sapiens 143-148
32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 interleukin 1 alpha Homo sapiens 178-186
32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 interleukin 18 Homo sapiens 188-193
32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 gasdermin D Homo sapiens 199-210
30318954-0 2020 Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid. Uric Acid 121-130 nuclear receptor subfamily 3, group C, member 2 Rattus norvegicus 12-38
32658422-8 2020 Baseline GA, age, and uric acid (p < 0.05) were identified as risk factors for renal dysfunction with a 30% or more decrease of eGFR. Uric Acid 22-31 epidermal growth factor receptor Homo sapiens 128-132
33062187-3 2020 The selected compound 11 (dotinurad, FYU-981) demonstrated remarkable inhibitory activity on uric acid uptake by primary human renal proximal tubule epithelial cells (RPTECs) and URAT1-mediated uric acid transport, with weak inhibitory activity against mitochondrial respiration. Uric Acid 194-203 solute carrier family 22 member 12 Homo sapiens 179-184
33693264-0 2020 Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock. Uric Acid 13-18 solute carrier family 16 member 9 Homo sapiens 34-63
33693264-1 2020 Background: Monocarboxylate transporter 9 (MCT9), an orphan transporter member of the solute carrier family 16 (SLC16), possibly reabsorbs uric acid in the renal tubule and has been suggested by genome-wide association studies to be involved in the development of hyperuricemia and gout. Uric Acid 139-148 solute carrier family 16 member 9 Homo sapiens 12-41
33693264-1 2020 Background: Monocarboxylate transporter 9 (MCT9), an orphan transporter member of the solute carrier family 16 (SLC16), possibly reabsorbs uric acid in the renal tubule and has been suggested by genome-wide association studies to be involved in the development of hyperuricemia and gout. Uric Acid 139-148 solute carrier family 16 member 9 Homo sapiens 43-47
33693264-3 2020 Methods and Results: hMCT9-FLAG was stably expressed in HEK293 cells and its degradation, intracellular localization, and urate uptake activities were assessed by pulse-chase analysis, immunofluorescence, and [14C]-urate uptake experiments, respectively. Uric Acid 122-127 solute carrier family 16 member 9 Homo sapiens 21-26
33693264-3 2020 Methods and Results: hMCT9-FLAG was stably expressed in HEK293 cells and its degradation, intracellular localization, and urate uptake activities were assessed by pulse-chase analysis, immunofluorescence, and [14C]-urate uptake experiments, respectively. Uric Acid 215-220 solute carrier family 16 member 9 Homo sapiens 21-26
33693264-5 2020 The proteasome inhibitors MG132 and lactacystine increased levels of hMCT9-FLAG protein expression with enhanced ubiquitination, prolonged their half-life, and decreased [14C]-urate uptake. Uric Acid 176-181 solute carrier family 16 member 9 Homo sapiens 69-79
33693264-8 2020 Conclusions: hMCT9 does transport urate and is degraded by a proteasome, inhibition of which reduces hMCT9 expression on the cell membrane and urate uptake. Uric Acid 34-39 solute carrier family 16 member 9 Homo sapiens 13-18
33693264-8 2020 Conclusions: hMCT9 does transport urate and is degraded by a proteasome, inhibition of which reduces hMCT9 expression on the cell membrane and urate uptake. Uric Acid 34-39 solute carrier family 16 member 9 Homo sapiens 101-106
33693264-8 2020 Conclusions: hMCT9 does transport urate and is degraded by a proteasome, inhibition of which reduces hMCT9 expression on the cell membrane and urate uptake. Uric Acid 143-148 solute carrier family 16 member 9 Homo sapiens 13-18
33693264-9 2020 HS enhanced urate uptake through hMCT9. Uric Acid 12-17 solute carrier family 16 member 9 Homo sapiens 33-38
32452918-2 2020 In the evolutionary process, humans lost uricase, an enzyme that converts uric acid into allantoin, resulting in increased serum uric acid levels that may vary according to dietary ingestion, pathological conditions, and other factors. Uric Acid 129-138 urate oxidase (pseudogene) Homo sapiens 41-48
32452918-3 2020 Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Uric Acid 54-63 NLR family pyrin domain containing 3 Homo sapiens 132-137
32452918-3 2020 Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Uric Acid 97-106 NLR family pyrin domain containing 3 Homo sapiens 132-137
32567553-9 2020 PCA of biomarkers revealed a pattern on PC1 from favourable lipid markers (HDL-cholesterol, adiponectin) towards unfavourable markers (triglycerides, LDL-cholesterol, apo-B, uric acid). Uric Acid 174-183 proprotein convertase subtilisin/kexin type 1 Homo sapiens 40-43
32452918-8 2020 Despite these conflicting views, several studies support the idea that hyperuricemia is indeed a cause of progression of kidney disease, with a putative role for soluble uric acid in activating renal NLRP3 inflammasome, in reprograming renal and immune cell metabolism and, therefore, in promoting kidney inflammation/injury. Uric Acid 170-179 NLR family pyrin domain containing 3 Homo sapiens 200-205
32452918-9 2020 SUMMARY: Therapies aiming to decrease uric acid levels prevent renal NLRP3 inflammasome activation and exert renoprotective effects in experimental kidney diseases. Uric Acid 38-47 NLR family pyrin domain containing 3 Homo sapiens 69-74
32380019-2 2020 The enzymatic complex of xanthine oxidoreductase (XOR) is involved in the generation of reactive oxygen species (ROS) and uric acid that, in the end, can cause reperfusion injuries, irritation and pathological conditions. Uric Acid 122-131 xanthine dehydrogenase Homo sapiens 25-48
32380019-2 2020 The enzymatic complex of xanthine oxidoreductase (XOR) is involved in the generation of reactive oxygen species (ROS) and uric acid that, in the end, can cause reperfusion injuries, irritation and pathological conditions. Uric Acid 122-131 xanthine dehydrogenase Homo sapiens 50-53
32387086-7 2020 It was found that CL/F increases with serum creatinine and uric acid levels and V1/F is modified by blood urea nitrogen and the UGT1A9 genotype. Uric Acid 59-68 cytokine receptor like factor 1 Homo sapiens 18-22
32599713-2 2020 In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age. Uric Acid 114-123 insulin Homo sapiens 146-153
33511070-15 2020 In addition, insulin resistance was observed more frequently in these patients compared to the general population, and insulin resistance was found to be associated with high BMI, hepatosteatosis rate, VLDL, TG, GGT, total protein, uric acid, TG/HDL ratio, and low HDL. Uric Acid 232-241 insulin Homo sapiens 119-126
32606291-0 2020 A highly sensitive uric acid electrochemical biosensor based on a nano-cube cuprous oxide/ferrocene/uricase modified glassy carbon electrode. Uric Acid 19-28 urate oxidase (pseudogene) Homo sapiens 100-107
32606291-1 2020 A uric acid (UA) electrochemical biosensor was constructed using ferrocene (Fc) decorated cuprous oxide (Cu2O) enhanced electro-active characteristics and covalently immobilized with uricase (UOx) on glassy carbon electrode (GCE). Uric Acid 2-11 urate oxidase (pseudogene) Homo sapiens 183-190
32606291-1 2020 A uric acid (UA) electrochemical biosensor was constructed using ferrocene (Fc) decorated cuprous oxide (Cu2O) enhanced electro-active characteristics and covalently immobilized with uricase (UOx) on glassy carbon electrode (GCE). Uric Acid 2-11 urate oxidase (pseudogene) Homo sapiens 192-195
32606291-1 2020 A uric acid (UA) electrochemical biosensor was constructed using ferrocene (Fc) decorated cuprous oxide (Cu2O) enhanced electro-active characteristics and covalently immobilized with uricase (UOx) on glassy carbon electrode (GCE). Uric Acid 13-15 urate oxidase (pseudogene) Homo sapiens 183-190
32606291-1 2020 A uric acid (UA) electrochemical biosensor was constructed using ferrocene (Fc) decorated cuprous oxide (Cu2O) enhanced electro-active characteristics and covalently immobilized with uricase (UOx) on glassy carbon electrode (GCE). Uric Acid 13-15 urate oxidase (pseudogene) Homo sapiens 192-195
32606291-3 2020 DPV studies revealed rapid response of fabricated electrode UOx/Fc/Cu2O/GCE towards UA in a wide concentration range of 0.1-1,000 muM with a sensitivity of 1.900 muA mM-1 cm-2 and very low detection limit of 0.0596 muM. Uric Acid 84-86 urate oxidase (pseudogene) Homo sapiens 60-63
32536991-1 2020 Crystalized deposits of monosodium urate activate the Nod-like receptor protein 3 (NLRP3) inflammasome, resulting in kidney damage. Uric Acid 24-40 NLR family pyrin domain containing 3 Homo sapiens 54-81
32536991-1 2020 Crystalized deposits of monosodium urate activate the Nod-like receptor protein 3 (NLRP3) inflammasome, resulting in kidney damage. Uric Acid 24-40 NLR family pyrin domain containing 3 Homo sapiens 83-88
32180207-0 2020 Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients. Uric Acid 65-74 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 14-19
32180207-3 2020 This prospective cohort study of 1214 hemodialysis patients investigated the association between serum uric acid levels and ABCG2 genotype and mortality. Uric Acid 103-112 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 124-129
32180207-7 2020 ABCG2 dysfunction, estimated by genetic variants, had a significant positive association with serum uric acid levels (full function: 7.4 +- 1.2 mg/dl, 3/4 function: 7.9 +- 1.3 mg/dl, 1/2 function: 8.2 +- 1.4 mg/dl, <= 1/4 function: 8.7 +- 1.3 mg/dl, P <= 0.001). Uric Acid 100-109 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
32180207-10 2020 These results showed that ABCG2 plays a physiologically important role in uric acid excretion, and that ABCG2 dysfunction is a risk factor for mortality in hemodialysis patients. Uric Acid 74-83 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 26-31
31916414-1 2020 AIMS: Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species. Uric Acid 6-15 xanthine dehydrogenase Homo sapiens 100-123
31916414-1 2020 AIMS: Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species. Uric Acid 6-15 xanthine dehydrogenase Homo sapiens 125-128
32272047-0 2020 Re: Targeted Renal Knockdown of Na+/H+ Exchanger Regulatory Factor Sip1 Produces Uric Acid Nephrolithiasis in Drosophila. Uric Acid 81-90 septin interacting protein 1 Drosophila melanogaster 67-71
32533118-6 2020 Genetic approaches, studying both monogenic and polygenic factors in nephrolithiasis, have revealed that the following have important roles in the aetiology of kidney stones: transporters and channels; ions, protons and amino acids; the calcium-sensing receptor (a G protein-coupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, purines and uric acid. Uric Acid 386-395 calcium sensing receptor Homo sapiens 237-261
32488095-0 2020 The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. Uric Acid 94-99 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 4-9
32488095-2 2020 Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. Uric Acid 196-201 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 111-116
32488095-2 2020 Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. Uric Acid 196-201 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 159-164
32488095-2 2020 Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. Uric Acid 267-272 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 111-116
32488095-2 2020 Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. Uric Acid 267-272 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 159-164
32488095-3 2020 We explore mechanisms by generating a mouse model of the orthologous Q140K Abcg2 variant and find male mice have significant hyperuricemia and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 abundance. Uric Acid 203-208 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 75-80
32488095-5 2020 These results suggest a tissue specific pathobiology of the Q141K variant, support an important role for ABCG2 in urate excretion in both the human kidney and intestinal tract, and provide insight into the importance of intestinal urate excretion for serum urate homeostasis. Uric Acid 114-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 105-110
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 29-34 solute carrier family 22 member 12 Homo sapiens 135-154
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 29-34 solute carrier family 22 member 12 Homo sapiens 156-161
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 126-131 solute carrier family 22 member 12 Homo sapiens 135-154
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 126-131 solute carrier family 22 member 12 Homo sapiens 156-161
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 126-131 solute carrier family 22 member 12 Homo sapiens 163-197
32327267-1 2020 Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. Uric Acid 126-131 solute carrier family 22 member 12 Homo sapiens 199-207
32695290-0 2020 Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells. Uric Acid 8-17 toll like receptor 4 Homo sapiens 43-47
32695290-0 2020 Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 48-53
32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 translocator protein Homo sapiens 135-139
32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 toll like receptor 4 Homo sapiens 169-173
32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 NLR family pyrin domain containing 3 Homo sapiens 178-183
32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 NLR family pyrin domain containing 3 Homo sapiens 204-209
32695290-13 2020 Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Uric Acid 94-103 interleukin 1 alpha Homo sapiens 26-34
32695290-13 2020 Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Uric Acid 94-103 toll like receptor 4 Homo sapiens 69-73
32695290-13 2020 Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Uric Acid 94-103 toll like receptor 4 Homo sapiens 133-137
32695290-13 2020 Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Uric Acid 94-103 NLR family pyrin domain containing 3 Homo sapiens 138-143
32695290-14 2020 Conclusion: Soluble uric acid exerted detrimental effect on intestinal epithelial cells through the TLR4/NLRP3 pathway. Uric Acid 20-29 toll like receptor 4 Homo sapiens 100-104
32695290-14 2020 Conclusion: Soluble uric acid exerted detrimental effect on intestinal epithelial cells through the TLR4/NLRP3 pathway. Uric Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 105-110
32340426-11 2020 After adjustment for age, sex, fasting plasma glucose and creatinine, cystatin C was positively correlated with the duration of diabetes, systolic blood pressure (SBP), total cholesterol, triglycerides, uric acid and low-density lipoprotein cholesterol (P=0.004, P=0.022, P=0.013, P=0.035, P=0.006, P=0.012, respectively) and negatively correlated with hemoglobin (P<0.001). Uric Acid 203-212 cystatin C Homo sapiens 70-80
32469177-0 2020 Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. Uric Acid 17-33 NLR family pyrin domain containing 3 Homo sapiens 42-47
31925474-10 2020 Treatment with SPL however attenuated the elevated testosterone in the LET-induced PCOS model accompanied with a reversal in the observed ovarian and hepatic UA, TG accumulation, and altered histomorphological changes. Uric Acid 158-160 sphingosine-1-phosphate lyase 1 Homo sapiens 15-18
32620198-6 2020 Renal elimination of urate depends substantially on specific transporters, including URAT1, GLUT9 and BCRP. Uric Acid 21-26 solute carrier family 22 member 12 Homo sapiens 85-90
32620198-6 2020 Renal elimination of urate depends substantially on specific transporters, including URAT1, GLUT9 and BCRP. Uric Acid 21-26 solute carrier family 2 member 9 Homo sapiens 92-97
32620198-6 2020 Renal elimination of urate depends substantially on specific transporters, including URAT1, GLUT9 and BCRP. Uric Acid 21-26 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 102-106
32536670-6 2020 Favipiravir and M1 act as moderate inhibitors of organic anion transporter 1 and 3 (OAT1 and OAT3), which are involved in uric acid excretion in the kidney. Uric Acid 122-131 solute carrier family 22 member 6 Homo sapiens 49-82
32536670-6 2020 Favipiravir and M1 act as moderate inhibitors of organic anion transporter 1 and 3 (OAT1 and OAT3), which are involved in uric acid excretion in the kidney. Uric Acid 122-131 solute carrier family 22 member 6 Homo sapiens 84-88
32536670-6 2020 Favipiravir and M1 act as moderate inhibitors of organic anion transporter 1 and 3 (OAT1 and OAT3), which are involved in uric acid excretion in the kidney. Uric Acid 122-131 solute carrier family 22 member 8 Homo sapiens 93-97
32536670-7 2020 In addition, M1 enhances uric acid reuptake via urate transporter 1 (URAT1) in the renal proximal tubules. Uric Acid 25-34 solute carrier family 22 member 12 Homo sapiens 48-67
32536670-7 2020 In addition, M1 enhances uric acid reuptake via urate transporter 1 (URAT1) in the renal proximal tubules. Uric Acid 25-34 solute carrier family 22 member 12 Homo sapiens 69-74
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 NLR family pyrin domain containing 3 Homo sapiens 95-131
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 NLR family pyrin domain containing 3 Homo sapiens 133-138
32469177-0 2020 Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. Uric Acid 17-33 aryl hydrocarbon receptor Homo sapiens 90-93
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 aryl hydrocarbon receptor Homo sapiens 181-206
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 aryl hydrocarbon receptor Homo sapiens 208-211
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 thioredoxin interacting protein Homo sapiens 217-248
32469177-0 2020 Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. Uric Acid 17-33 thioredoxin interacting protein Homo sapiens 98-103
32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 thioredoxin interacting protein Homo sapiens 250-255
32469177-3 2020 MATERIALS AND METHODS: Human myeloid leukemia cells (U937 cells) were used to assess the role of ethanol in NLRP3 inflammasome activation induced by monosodium urate (MSU) crystals. Uric Acid 149-165 NLR family pyrin domain containing 3 Homo sapiens 108-113
32446261-7 2021 The area under the curve (AUC) of sFlt-1/PlGF ratio was 0.82 (95% confidence interval [CI]: 0.73-0.88) for the risk of AMFO and the difference between the AUCs was significant for each separate standard parameter (p = 0.018 for initial diastolic blood pressure, p = 0.013 for alanine aminotransferase, p < 0.001 for uric acid). Uric Acid 316-325 placental growth factor Homo sapiens 41-45
32469177-3 2020 MATERIALS AND METHODS: Human myeloid leukemia cells (U937 cells) were used to assess the role of ethanol in NLRP3 inflammasome activation induced by monosodium urate (MSU) crystals. Uric Acid 167-170 NLR family pyrin domain containing 3 Homo sapiens 108-113
32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 118-121 NLR family pyrin domain containing 3 Homo sapiens 33-38
32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 118-121 interleukin 1 alpha Homo sapiens 43-51
32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 118-121 thioredoxin interacting protein Homo sapiens 141-146
32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 224-227 thioredoxin interacting protein Homo sapiens 141-146
32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 224-227 thioredoxin interacting protein Homo sapiens 141-146
32469177-11 2020 CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. Uric Acid 31-40 NLR family pyrin domain containing 3 Homo sapiens 49-54
32469177-11 2020 CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. Uric Acid 31-40 aryl hydrocarbon receptor Homo sapiens 101-104
32469177-11 2020 CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. Uric Acid 31-40 thioredoxin interacting protein Homo sapiens 125-130
32486008-0 2020 Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber. Uric Acid 81-86 solute carrier family 22 member 12 Homo sapiens 66-71
32486008-4 2020 In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. Uric Acid 11-16 solute carrier family 22 member 12 Homo sapiens 123-142
32486008-4 2020 In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. Uric Acid 11-16 solute carrier family 22 member 12 Homo sapiens 144-149
32486008-5 2020 URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Uric Acid 56-61 solute carrier family 22 member 12 Homo sapiens 0-5
32486008-5 2020 URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Uric Acid 100-105 solute carrier family 22 member 12 Homo sapiens 0-5
32404047-9 2020 XDH could affect purine metabolism by suppressing the expression of hypoxanthine and xanthine leading to low serum levels of uric acid in OTLF, which could be a focal point in developing new therapeutic methods for OTLF. Uric Acid 125-134 xanthine dehydrogenase Homo sapiens 0-3
32509185-8 2020 Uric acid increased the gene expression of Nppa, Nppb, and Myh5, which are involved in myocardial hypertrophy, and the relative cell surface area of cardiomyocytes in a dose-dependent manner. Uric Acid 0-9 natriuretic peptide A Homo sapiens 43-47
32509185-8 2020 Uric acid increased the gene expression of Nppa, Nppb, and Myh5, which are involved in myocardial hypertrophy, and the relative cell surface area of cardiomyocytes in a dose-dependent manner. Uric Acid 0-9 natriuretic peptide B Homo sapiens 49-53
32509185-8 2020 Uric acid increased the gene expression of Nppa, Nppb, and Myh5, which are involved in myocardial hypertrophy, and the relative cell surface area of cardiomyocytes in a dose-dependent manner. Uric Acid 0-9 myosin heavy chain 16 pseudogene Homo sapiens 59-63
32509185-11 2020 Treatment with uric acid increased the level of phosphorylated adenosine monophosphate kinase (AMPK), as well as its downstream effector unc-51-like kinase (ULK1). Uric Acid 15-24 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 63-93
32509185-11 2020 Treatment with uric acid increased the level of phosphorylated adenosine monophosphate kinase (AMPK), as well as its downstream effector unc-51-like kinase (ULK1). Uric Acid 15-24 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 95-99
32509185-11 2020 Treatment with uric acid increased the level of phosphorylated adenosine monophosphate kinase (AMPK), as well as its downstream effector unc-51-like kinase (ULK1). Uric Acid 15-24 unc-51 like autophagy activating kinase 1 Homo sapiens 157-161
32509185-12 2020 Pharmacological inhibition of AMPK by Compound C attenuated the uric acid-induced activation of autophagy and myocardial hypertrophy. Uric Acid 64-73 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34
32509185-13 2020 CONCLUSIONS: Uric acid induces myocardial hypertrophy by activating autophagy via the AMPK-ULK1 signaling pathway. Uric Acid 13-22 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 86-90
32509185-13 2020 CONCLUSIONS: Uric acid induces myocardial hypertrophy by activating autophagy via the AMPK-ULK1 signaling pathway. Uric Acid 13-22 unc-51 like autophagy activating kinase 1 Homo sapiens 91-95
32404204-9 2020 Preferential SIRT1 activation may also explain the ability of SGLT2 inhibitors to stimulate erythropoiesis and reduce uric acid (a biomarker of oxidative stress)-effects that are not seen with metformin. Uric Acid 118-127 sirtuin 1 Homo sapiens 13-18
32404204-9 2020 Preferential SIRT1 activation may also explain the ability of SGLT2 inhibitors to stimulate erythropoiesis and reduce uric acid (a biomarker of oxidative stress)-effects that are not seen with metformin. Uric Acid 118-127 solute carrier family 5 member 2 Homo sapiens 62-67
32454796-7 2020 Furthermore, in LLIs, we found a positive correlation of MMP-2 with the antioxidant catabolite uric acid and a negative correlation with the inflammatory marker C-reactive protein. Uric Acid 95-104 matrix metallopeptidase 2 Homo sapiens 57-62
32404204-10 2020 Changes in both hematocrit and serum urate are the most important predictors of the ability of SGLT2 inhibitors to reduce the risk of cardiovascular death and hospitalization for heart failure in large-scale trials. Uric Acid 37-42 solute carrier family 5 member 2 Homo sapiens 95-100
32384273-10 2020 Subjects in the OPLL-P group were significantly younger (p = 0.031), had higher prevalence of multilevel OPLL involvement (p = 0.041) and continuous type of OPLL (p = 0.015), and had higher uric acid (UA) levels (p = 0.004) at the time of initial CT examination compared to the OPLL-NP group. Uric Acid 190-199 OPLL Homo sapiens 16-20
32375679-2 2020 These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Uric Acid 51-57 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 143-148
32375679-2 2020 These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Uric Acid 51-57 solute carrier family 17 member 1 Homo sapiens 153-160
32375679-2 2020 These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Uric Acid 126-132 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 143-148
32375679-2 2020 These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Uric Acid 126-132 solute carrier family 17 member 1 Homo sapiens 153-160
32375679-12 2020 CONCLUSION: We found a case of RHUC1 carrying mutations in SLC22A12 gene accompanied with compensatory mutations associated with hyperuricemia, representing the first report showing coexistence of the mutations with opposed potential to regulate urate concentrations. Uric Acid 246-251 solute carrier family 22 member 12 Homo sapiens 59-67
32006589-0 2020 Intramolecular distance in the conjugate of urate oxidase and fatty acid governs FcRn binding and serum half-life in vivo. Uric Acid 44-49 Fc gamma receptor and transporter Homo sapiens 81-85
31883118-10 2020 Eucalyptol attenuated MSU-induced upregulation of TRPV1 expression in ankle tissues and dorsal root ganglion neurons innervating the ankle. Uric Acid 22-25 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 50-55
31883118-11 2020 The in vivo effects of eucalyptol on ankle edema, mechanical allodynia, NLRP3 inflammasome, IL-1beta and TRPV1 expression were mimicked by treating MSU-injected mice with anti-oxidants. Uric Acid 148-151 interleukin 1 beta Mus musculus 92-100
31883118-11 2020 The in vivo effects of eucalyptol on ankle edema, mechanical allodynia, NLRP3 inflammasome, IL-1beta and TRPV1 expression were mimicked by treating MSU-injected mice with anti-oxidants. Uric Acid 148-151 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 105-110
32067994-1 2020 Xanthinuria is a rare genetic metabolic disorder, the biochemical mechanism of xanthinuria is the disturbance of purine to uric acid metabolism due to the deficiency of xanthine dehydrogenase/xanthine oxidase (XDH/XO) and aldehyde oxidase 1 (AOX1). Uric Acid 123-132 xanthine dehydrogenase Homo sapiens 210-216
32092293-9 2020 Plasma miR-518b was significantly higher in the group of preeclampsia patients with proteinuria above the 75th percentile for the group (P = 0.033), in women who smoked (P = 0.039), and was positively related to uric acid in preeclampsia (P = 0.018, r = 0.536). Uric Acid 212-221 microRNA 518b Homo sapiens 7-15
31691260-0 2020 Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. Uric Acid 44-53 leptin Homo sapiens 12-18
31994785-7 2020 In addition, serum UA levels were significantly associated with DAT availability in the posterior putamen on both the more affected (r = 0.312, p = 0.005) and less affected side (r = 0.312, p = 0.005) only in male PD patients. Uric Acid 19-21 solute carrier family 6 member 3 Homo sapiens 64-67
31994785-8 2020 CONCLUSIONS: The present study demonstrated the potentially close sex-specific relationship between the serum UA levels and the anterior-posterior gradient of DAT patterns, suggesting a sex-specific protective effect of UA on nigrostriatal dopaminergic neurons in de novo PD. Uric Acid 110-112 solute carrier family 6 member 3 Homo sapiens 159-162
31994785-8 2020 CONCLUSIONS: The present study demonstrated the potentially close sex-specific relationship between the serum UA levels and the anterior-posterior gradient of DAT patterns, suggesting a sex-specific protective effect of UA on nigrostriatal dopaminergic neurons in de novo PD. Uric Acid 220-222 solute carrier family 6 member 3 Homo sapiens 159-162
31691260-3 2020 However, there are few observational data on the relationship between leptin and uric acid in the general population. Uric Acid 81-90 leptin Homo sapiens 70-76
31691260-2 2020 Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. Uric Acid 59-68 leptin Homo sapiens 33-39
31691260-2 2020 Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. Uric Acid 91-100 leptin Homo sapiens 33-39
31691260-4 2020 Therefore, the aim of the present study was to evaluate the relationship between leptin and uric acid and its excretion in a large middle-aged male general population. Uric Acid 92-101 leptin Homo sapiens 81-87
32204055-9 2020 The resulting catalytic current at the surfaces showed a linear dependence to the concentrations of UA, XA and CA for up to 225, 225 and 1500 muM, respectively. Uric Acid 100-102 latexin Homo sapiens 142-145
31691260-6 2020 RESULTS: Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). Uric Acid 9-18 insulin Homo sapiens 110-117
31691260-6 2020 RESULTS: Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). Uric Acid 9-18 C-reactive protein Homo sapiens 130-148
31691260-6 2020 RESULTS: Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). Uric Acid 9-18 leptin Homo sapiens 153-159
31691260-7 2020 The multivariate analysis confirmed the association between leptin and uric acid after adjustment for potential confounders (p < 0.01). Uric Acid 71-80 leptin Homo sapiens 60-66
31691260-9 2020 Moreover, leptin was inversely associated with excretion of uric acid (p < 0.01), also in multivariate analysis (p = 0.03). Uric Acid 60-69 leptin Homo sapiens 10-16
31691260-10 2020 CONCLUSION: The results of this study indicate a positive association between circulating leptin levels and uric acid, independently of potential confounders, both in normal and excess body weight men. Uric Acid 108-117 leptin Homo sapiens 90-96
31691260-11 2020 Furthermore, an inverse association between leptin and uric acid excretion was detected. Uric Acid 55-64 leptin Homo sapiens 44-50
30926902-6 2020 MMP-14 expression correlated with BMI-SDS (p = 0.001; r = 0.371), waist circumference-SDS (p = 0.016; r = 0.290), hsCRP (p = 0.003; r = 0.350), serum HDL-cholesterol (p = 0.008; r = -0.304), and serum uric acid (p = 0.0001; r = 0.394). Uric Acid 201-210 matrix metallopeptidase 14 Homo sapiens 0-6
32150484-1 2020 Aster glehni extracts (AGE) reduced serum uric acid levels in hyperuricemia rats in several previous studies. Uric Acid 42-51 renin binding protein Rattus norvegicus 23-26
32150484-3 2020 This study aimed at investigating the efficacy and safety of AGE on the anti-hyperuricemia effect in subjects with slightly high serum uric acid. Uric Acid 135-144 renin binding protein Homo sapiens 61-64
32150484-9 2020 Six weeks of AGE supplementation significantly reduced serum uric acid level from baseline (P = .0468) but at the end of the intervention the participants did not show the beneficial effect of AGE supplementation. Uric Acid 61-70 renin binding protein Homo sapiens 13-16
32297137-4 2020 The NLRP3 inflammasome triggers include ATP, nigericin, aluminum crystals, and monosodium urate crystals, and NLRP3 activation induces IL-1beta secretion in a dose-dependent manner. Uric Acid 79-95 NLR family pyrin domain containing 3 Equus caballus 4-9
31760563-10 2020 Uric acid concentration was lower (P < 0.05) in FBP-10 and FBP-15 than in CONT. Uric Acid 0-9 fructose-1,6-bisphosphatase, chloroplastic Glycine max 59-65
32419834-0 2020 Huzhang Tongfeng Granule Improves Monosodium Urate-Induced Inflammation of Gouty Arthritis Rat Model by Downregulation of Cyr61 and Related Cytokines. Uric Acid 34-50 cellular communication network factor 1 Rattus norvegicus 122-127
32239172-6 2020 Though the expression of xanthine oxidase, which generates UA, was not different in liver and intestine between wild type and Hfe-/- mice, the enzymatic activity was higher in Hfe-/- mice. Uric Acid 59-61 xanthine dehydrogenase Mus musculus 25-41
31085741-0 2020 Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography/triple quadrupole mass spectrometry: MedCity21 health examination registry. Uric Acid 78-87 xanthine dehydrogenase Homo sapiens 34-57
31085741-7 2020 Multivariable linear regression analysis showed a significant and positive association of serum uric acid level (coefficient: 26.503; 95% confidence interval: 2.06, 50.945; p = 0.035) with plasma XOR activity independent of VFA and HOMA-IR, and also age, gender, alcohol drinking habit, systolic blood pressure, estimated glomerular filtration rate (eGFR), glycated hemoglobin A1c, triglyceride, and adiponectin levels. Uric Acid 96-105 xanthine dehydrogenase Homo sapiens 196-199
31085741-7 2020 Multivariable linear regression analysis showed a significant and positive association of serum uric acid level (coefficient: 26.503; 95% confidence interval: 2.06, 50.945; p = 0.035) with plasma XOR activity independent of VFA and HOMA-IR, and also age, gender, alcohol drinking habit, systolic blood pressure, estimated glomerular filtration rate (eGFR), glycated hemoglobin A1c, triglyceride, and adiponectin levels. Uric Acid 96-105 adiponectin, C1Q and collagen domain containing Homo sapiens 400-411
31085741-9 2020 Conclusions Plasma XOR activity was found to be positively associated with serum uric acid level independent of other known confounding factors affecting that level, including gender difference, eGFR, adiponectin level, VFA, and HOMA-IR. Uric Acid 81-90 xanthine dehydrogenase Homo sapiens 19-22
32317707-5 2020 (2) The serum urea level in Silky chickens was twice of broilers; exogenous insulin significantly up-regulated serum uric acid level in Silky fowls in a time-dependent manner and increased serum cholesterol content at 120 min. Uric Acid 117-126 insulin Gallus gallus 76-83
32325916-0 2020 The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment. Uric Acid 52-61 methylenetetrahydrofolate reductase Homo sapiens 89-94
31985003-7 2020 We demonstrate that OAT7 is a very weak urate-butyrate exchanger. Uric Acid 40-54 solute carrier family 22 member 9 Homo sapiens 20-24
32271837-0 2020 A population-specific low-frequency variant of SLC22A12 (p.W258*) explains nearby genome-wide association signals for serum uric acid concentrations among Koreans. Uric Acid 124-133 solute carrier family 22 member 12 Homo sapiens 47-55
32271837-2 2020 Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly confirmed genetic loci including those encoding uric acid transporters such as ABCG2 and SLC9A2. Uric Acid 50-59 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 176-181
32271837-2 2020 Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly confirmed genetic loci including those encoding uric acid transporters such as ABCG2 and SLC9A2. Uric Acid 50-59 solute carrier family 9 member A2 Homo sapiens 186-192
32271837-2 2020 Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly confirmed genetic loci including those encoding uric acid transporters such as ABCG2 and SLC9A2. Uric Acid 145-154 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 176-181
32271837-2 2020 Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly confirmed genetic loci including those encoding uric acid transporters such as ABCG2 and SLC9A2. Uric Acid 145-154 solute carrier family 9 member A2 Homo sapiens 186-192
31985003-8 2020 Newly implicated genes identified in the eQTL analysis include those encoding proteins that make up the dystrophin complex, a scaffold for signaling proteins and transporters at the cell membrane; MLXIP that, with the previously identified MLXIPL, is a transcription factor that may regulate serum urate via the pentose-phosphate pathway; and MRPS7 and IDH2 that encode proteins necessary for mitochondrial function. Uric Acid 298-303 MLX interacting protein Homo sapiens 197-202
31985003-8 2020 Newly implicated genes identified in the eQTL analysis include those encoding proteins that make up the dystrophin complex, a scaffold for signaling proteins and transporters at the cell membrane; MLXIP that, with the previously identified MLXIPL, is a transcription factor that may regulate serum urate via the pentose-phosphate pathway; and MRPS7 and IDH2 that encode proteins necessary for mitochondrial function. Uric Acid 298-303 MLX interacting protein like Homo sapiens 240-246
32318576-7 2020 HLA-B27-negative patients showed higher levels of uric acid (UA) than those who were HLA-B27-positive. Uric Acid 50-59 major histocompatibility complex, class I, B Homo sapiens 0-7
32318576-7 2020 HLA-B27-negative patients showed higher levels of uric acid (UA) than those who were HLA-B27-positive. Uric Acid 61-63 major histocompatibility complex, class I, B Homo sapiens 0-7
32114511-1 2020 OBJECTIVE: Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals. Uric Acid 101-117 interleukin 1 alpha Homo sapiens 43-61
32215662-8 2020 Loss-of-function guanine deaminase mutants reduced the metabolic end-product uric acid, which was increased by exposure to exogenous xanthine. Uric Acid 77-86 guanine deaminase Homo sapiens 17-34
32215662-11 2020 Overall, guanine deaminase upregulation increased UV-induced keratinocyte senescence in SK, via uric acid mediated by reactive oxygen species followed by DNA damage. Uric Acid 96-105 guanine deaminase Homo sapiens 9-26
31926987-8 2020 Further, PPT inhibited IL-1beta secretion in both LPS-induced septic shock and MSU-induced mouse peritonitis models. Uric Acid 79-82 interleukin 1 alpha Mus musculus 23-31
32215662-4 2020 The guanine deaminase gene, which is involved in purine metabolism, was upregulated with uric acid levels and p21 in SK. Uric Acid 89-98 guanine deaminase Homo sapiens 4-21
31834126-7 2020 The causal mediation analysis found that UACR partially mediated the association of baseline uric acid with follow-up SBP (mediate proportion: 9.14%, 95% CI: 1.58-23.00%) and DBP (mediate proportion: 7.38%, 95% CI: 1.05-19.00%). Uric Acid 93-102 selenium binding protein 1 Homo sapiens 118-121
32005656-5 2020 By using genomic sequences of the ToMMo cohort, we identified rare variants of the SLC22A12 gene that affect the urate transport activity of URAT1. Uric Acid 113-118 solute carrier family 22 member 12 Homo sapiens 83-91
32005656-5 2020 By using genomic sequences of the ToMMo cohort, we identified rare variants of the SLC22A12 gene that affect the urate transport activity of URAT1. Uric Acid 113-118 solute carrier family 22 member 12 Homo sapiens 141-146
32005656-7 2020 We grouped the participants with variants affecting urate uptake by URAT1 and analyzed the variance of serum urate levels. Uric Acid 52-57 solute carrier family 22 member 12 Homo sapiens 68-73
32005656-8 2020 The results showed that the heritability explained by the SLC22A12 variants of men and women exceeds 10%, suggesting that rare variants underlie a substantial portion of the "missing heritability" of serum urate levels. Uric Acid 206-211 solute carrier family 22 member 12 Homo sapiens 58-66
31831430-7 2020 Thereafter, sensor probe was functionalized with the specific enzyme i.e. uricase for the UA detection. Uric Acid 90-92 urate oxidase (pseudogene) Homo sapiens 74-81
31831430-8 2020 The linearity response of uricase/GO/AuNPs-coated micro-ball optical fiber sensor is reported in the range of 10 muM - 1 mM UA concentrations. Uric Acid 124-126 urate oxidase (pseudogene) Homo sapiens 26-33
31406054-8 2020 Multivariable regression demonstrated that age, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein cholesterol, and serum uric acid were independent determinants of soluble endoglin. Uric Acid 166-175 endoglin Homo sapiens 217-225
32005544-8 2020 The resistin/uric acid index was positively correlated with BMI z-score change (r = 0.27, P < .01). Uric Acid 13-22 resistin Homo sapiens 4-12
32005544-9 2020 In the linear regression analysis, the resistin/uric acid index was significantly associated with BMI z-score modification at the 12-month follow-up (beta = 0.17; 95% CI 0.08-0.26; P < .01). Uric Acid 48-57 resistin Homo sapiens 39-47
32005544-10 2020 CONCLUSIONS: The resistin/uric acid index can be considered a prognostic factor for identifying adolescents with overweight or obesity with a greater probability of improving their BMI. Uric Acid 26-35 resistin Homo sapiens 17-25
32164582-12 2020 Uric acid was the only independent variable for predicting MMP-9 levels (p-value = 0.001). Uric Acid 0-9 matrix metallopeptidase 9 Homo sapiens 59-64
32095984-10 2020 Uric acid and HMGB1 siRNA inhibited HMGB1 acetylation to prevent its transport from the nucleus to the cytoplasm. Uric Acid 0-9 high mobility group box 1 Homo sapiens 36-41
32095984-12 2020 These data indicated that uric acid may prevent cell injury mainly by inhibiting HMGB1 acetylation to regulate TLR4/NF-kappaB pathways and reduce the levels of inflammatory factors. Uric Acid 26-35 high mobility group box 1 Homo sapiens 81-86
32095984-12 2020 These data indicated that uric acid may prevent cell injury mainly by inhibiting HMGB1 acetylation to regulate TLR4/NF-kappaB pathways and reduce the levels of inflammatory factors. Uric Acid 26-35 toll like receptor 4 Homo sapiens 111-115
32095984-12 2020 These data indicated that uric acid may prevent cell injury mainly by inhibiting HMGB1 acetylation to regulate TLR4/NF-kappaB pathways and reduce the levels of inflammatory factors. Uric Acid 26-35 nuclear factor kappa B subunit 1 Homo sapiens 116-125
32221804-2 2020 Uricase is for lowering the level of uric acid but unfortunately, it is not produced in humans due to evolutionary changes. Uric Acid 37-46 urate oxidase (pseudogene) Homo sapiens 0-7
32256360-16 2020 In vitro anti-inflammatory assay showed that extract of MPP roots inhibited MSU crystals-induced secretion of IL-1alpha, IL-1beta, IL-8, TNF-alpha, and PGE2 with IC50 values of 36, 25, 38, 18, and 46 mug/mL, respectively. Uric Acid 76-79 interleukin 1 alpha Rattus norvegicus 110-119
32256360-16 2020 In vitro anti-inflammatory assay showed that extract of MPP roots inhibited MSU crystals-induced secretion of IL-1alpha, IL-1beta, IL-8, TNF-alpha, and PGE2 with IC50 values of 36, 25, 38, 18, and 46 mug/mL, respectively. Uric Acid 76-79 interleukin 1 alpha Rattus norvegicus 121-129
32256360-16 2020 In vitro anti-inflammatory assay showed that extract of MPP roots inhibited MSU crystals-induced secretion of IL-1alpha, IL-1beta, IL-8, TNF-alpha, and PGE2 with IC50 values of 36, 25, 38, 18, and 46 mug/mL, respectively. Uric Acid 76-79 C-X-C motif chemokine ligand 8 Homo sapiens 131-135
32256360-16 2020 In vitro anti-inflammatory assay showed that extract of MPP roots inhibited MSU crystals-induced secretion of IL-1alpha, IL-1beta, IL-8, TNF-alpha, and PGE2 with IC50 values of 36, 25, 38, 18, and 46 mug/mL, respectively. Uric Acid 76-79 tumor necrosis factor Rattus norvegicus 137-146
32164793-0 2020 Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout. Uric Acid 67-72 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 26-31
32164793-2 2020 The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. Uric Acid 38-43 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 19-24
32095984-0 2020 The protective effect of uric acid in reducing TLR4/NF-kappaB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro. Uric Acid 25-34 toll like receptor 4 Homo sapiens 47-51
32095984-0 2020 The protective effect of uric acid in reducing TLR4/NF-kappaB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro. Uric Acid 25-34 nuclear factor kappa B subunit 1 Homo sapiens 52-61
32095984-0 2020 The protective effect of uric acid in reducing TLR4/NF-kappaB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro. Uric Acid 25-34 high mobility group box 1 Homo sapiens 99-104
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 interleukin 1 alpha Homo sapiens 132-154
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 interleukin 6 Homo sapiens 166-170
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 C-X-C motif chemokine ligand 8 Homo sapiens 172-176
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 tumor necrosis factor Homo sapiens 182-215
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 interleukin 1 alpha Homo sapiens 132-154
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 interleukin 6 Homo sapiens 166-170
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 C-X-C motif chemokine ligand 8 Homo sapiens 172-176
32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 tumor necrosis factor Homo sapiens 182-215
32355825-6 2020 Results: The plasma CXCL16 levels in IgAN patients were strongly correlated with the uric acid, estimated glomerular filtration rate and tubular atrophy/interstitial fibrosis score in multivariate analysis. Uric Acid 85-94 C-X-C motif chemokine ligand 16 Homo sapiens 20-26
32157204-1 2020 Xanthine oxidoreductase (XOR) inhibitor administration reduces uric acid and reactive oxygen species (ROS) production, and also lowers blood pressure (BP). Uric Acid 63-72 xanthine dehydrogenase Homo sapiens 0-23
32157204-1 2020 Xanthine oxidoreductase (XOR) inhibitor administration reduces uric acid and reactive oxygen species (ROS) production, and also lowers blood pressure (BP). Uric Acid 63-72 xanthine dehydrogenase Homo sapiens 25-28
31996020-0 2020 Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Uric Acid 8-17 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 53-81
31970593-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by selective inhibition of the urate transporter 1. Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 142-161
31996020-2 2020 Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Uric Acid 0-9 interleukin 1 alpha Homo sapiens 116-134
31996020-2 2020 Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Uric Acid 49-54 interleukin 1 alpha Homo sapiens 116-134
31996020-5 2020 Approach and Results: The secretion of IL-1beta from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid. Uric Acid 221-230 interleukin 1 alpha Homo sapiens 39-47
31996020-5 2020 Approach and Results: The secretion of IL-1beta from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid. Uric Acid 221-230 NLR family pyrin domain containing 3 Homo sapiens 106-111
31996020-7 2020 In both of uricase transgenic and xanthine oxidase inhibitor-treated mice, decreased levels of uric acid resulted in the activation of AMPK and attenuation of the development of atherosclerotic plaques. Uric Acid 95-104 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 135-139
31996020-8 2020 Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18-an inflammasome-dependent cytokine. Uric Acid 15-24 interleukin 18 Homo sapiens 135-140
31996020-10 2020 Moreover, the lowering of uric acid levels attenuated inflammation via the activation of the AMPK pathway. Uric Acid 26-35 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 93-97
32373197-0 2020 Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis. Uric Acid 30-39 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 49-54
32373197-7 2020 The ATP-Binding Cassette exporter ABCG2 is important in uric acid excretion at all three sites: kidney (urine), liver (bile), and intestine (feces). Uric Acid 56-65 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 34-39
31754882-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI) that has a future potential for the treatment of hyperuricemia, reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 41-46 solute carrier family 22 member 12 Homo sapiens 198-217
31754882-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI) that has a future potential for the treatment of hyperuricemia, reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 41-46 solute carrier family 22 member 12 Homo sapiens 219-224
31734460-3 2020 In this study, we investigated PDI oxidation by urate hydroperoxide, a newly-described oxidant that is generated through uric acid oxidation by peroxidases, with a putative role in vascular inflammation. Uric Acid 48-67 prolyl 4-hydroxylase subunit beta Homo sapiens 31-34
31734460-3 2020 In this study, we investigated PDI oxidation by urate hydroperoxide, a newly-described oxidant that is generated through uric acid oxidation by peroxidases, with a putative role in vascular inflammation. Uric Acid 121-130 prolyl 4-hydroxylase subunit beta Homo sapiens 31-34
31734460-4 2020 METHODS: Amino acids specificity and kinetics of PDI oxidation by urate hydroperoxide was evaluated by LC-MS/MS and by stopped-flow. Uric Acid 66-85 prolyl 4-hydroxylase subunit beta Homo sapiens 49-52
31734460-8 2020 RESULTS: Urate hydroperoxide specifically oxidized cysteine residues from catalytic sites of recombinant PDI with a rate constant of 6 x 103 M-1 s-1. Uric Acid 9-28 prolyl 4-hydroxylase subunit beta Homo sapiens 105-108
31734460-9 2020 Incubation of HUVECs with urate hydroperoxide led to oxidation of cell surface PDI and other unidentified cell surface thiol-proteins. Uric Acid 26-45 prolyl 4-hydroxylase subunit beta Homo sapiens 79-82
31734460-10 2020 Cell adherence to fibronectin coated plates was impaired by urate hydroperoxide, as well as by other oxidants, thiol alkylating agents and PDI inhibitors. Uric Acid 60-79 fibronectin 1 Homo sapiens 18-29
31734460-12 2020 CONCLUSIONS: Our results demonstrated that urate hydroperoxide affects thiol-oxidation of PDI and other cell surface proteins, impairing cellular adherence. Uric Acid 43-62 prolyl 4-hydroxylase subunit beta Homo sapiens 90-93
31823130-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. Uric Acid 86-95 solute carrier family 22 member 12 Homo sapiens 138-157
31823130-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. Uric Acid 86-95 solute carrier family 22 member 12 Homo sapiens 159-164
31875931-1 2020 BACKGROUND: Dotinurad is a novel selective urate reabsorption inhibitor (SURI) which reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 43-48 solute carrier family 22 member 12 Homo sapiens 142-161
31875931-1 2020 BACKGROUND: Dotinurad is a novel selective urate reabsorption inhibitor (SURI) which reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 43-48 solute carrier family 22 member 12 Homo sapiens 163-168
31754882-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI) that has a future potential for the treatment of hyperuricemia, reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 198-217
31754882-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI) that has a future potential for the treatment of hyperuricemia, reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 219-224
31754883-9 2020 Dotinurad is indicated for patients with hyperuricemia/gout as most patients with hyperuricemia are classified into "underexcretion type", which requires the inhibition of URAT-1 to excrete excess UA via the kidney. Uric Acid 197-199 solute carrier family 22 member 12 Homo sapiens 172-178
31875931-1 2020 BACKGROUND: Dotinurad is a novel selective urate reabsorption inhibitor (SURI) which reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 99-108 solute carrier family 22 member 12 Homo sapiens 142-161
31970593-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by selective inhibition of the urate transporter 1. Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 142-161
31875931-1 2020 BACKGROUND: Dotinurad is a novel selective urate reabsorption inhibitor (SURI) which reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1). Uric Acid 99-108 solute carrier family 22 member 12 Homo sapiens 163-168
32076889-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1. Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 129-148
31760530-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 129-148
31760530-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 150-155
32067130-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 149-168
32067130-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 170-175
31792640-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI), reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1) for the treatment of hyperuricemia with or without gout. Uric Acid 92-101 solute carrier family 22 member 12 Homo sapiens 135-154
31792640-1 2020 BACKGROUND: Dotinurad, a novel selective urate reabsorption inhibitor (SURI), reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1) for the treatment of hyperuricemia with or without gout. Uric Acid 92-101 solute carrier family 22 member 12 Homo sapiens 156-161
32067130-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). Uric Acid 101-110 solute carrier family 22 member 12 Homo sapiens 149-168
32067130-1 2020 BACKGROUND: Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). Uric Acid 101-110 solute carrier family 22 member 12 Homo sapiens 170-175
32044349-9 2020 Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Uric Acid 254-263 meteorin like, glial cell differentiation regulator Homo sapiens 6-12
31918161-4 2020 In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice. Uric Acid 113-129 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Mus musculus 17-23
31918161-4 2020 In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice. Uric Acid 113-129 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Mus musculus 31-37
31918161-4 2020 In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice. Uric Acid 113-129 interleukin 1 beta Mus musculus 77-85
31918161-4 2020 In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice. Uric Acid 113-129 NLR family, pyrin domain containing 3 Mus musculus 143-148
31918161-4 2020 In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice. Uric Acid 113-129 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Mus musculus 31-37
32044349-9 2020 Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Uric Acid 254-263 albumin Homo sapiens 157-160
32044349-9 2020 Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Uric Acid 265-267 meteorin like, glial cell differentiation regulator Homo sapiens 6-12
32044349-9 2020 Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Uric Acid 265-267 albumin Homo sapiens 157-160
32258131-6 2020 Mendelian randomization analysis was performed to estimate the causal effect using variation at rs11722228 (SLC2A9) as an instrument for uric acid. Uric Acid 137-146 solute carrier family 2 member 9 Homo sapiens 108-114
31748705-9 2020 Patients whose UA level increased more than 1 mg/dl showed significantly higher baseline office SBP and plasma glucose and showed greater decline in renal function compared with those who showed less UA increase (<1 mg/dl). Uric Acid 15-17 selenium binding protein 1 Homo sapiens 96-99
31927504-0 2020 Uric acid increases IL-1beta secretion and Caspase-1 activation in PBMCs of Behcet"s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol. Uric Acid 0-9 interleukin 1 beta Homo sapiens 20-28
31927504-0 2020 Uric acid increases IL-1beta secretion and Caspase-1 activation in PBMCs of Behcet"s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol. Uric Acid 0-9 caspase 1 Homo sapiens 43-52
31927504-9 2020 Additionally, while UA has markedly increased NO, IL-1beta, and Caspase-1 activity levels in PBMCs of BD patients, Allopurinol has exerted an immunomodulatory effect resulting in reduced NO, IL-1beta and Caspase-1 levels in PBMCs of BD patients particularly during the active stages. Uric Acid 20-22 interleukin 1 beta Homo sapiens 50-58
31927504-9 2020 Additionally, while UA has markedly increased NO, IL-1beta, and Caspase-1 activity levels in PBMCs of BD patients, Allopurinol has exerted an immunomodulatory effect resulting in reduced NO, IL-1beta and Caspase-1 levels in PBMCs of BD patients particularly during the active stages. Uric Acid 20-22 caspase 1 Homo sapiens 64-73
31720687-0 2020 Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia. Uric Acid 21-30 insulin Homo sapiens 57-64
31720687-3 2020 OBJECTIVE: To evaluate the impact of changes in uric acid over 2 years on changes in insulin sensitivity, beta-cell function, and glycemia in women with and without recent gestational diabetes (GDM), a model of the early natural history of T2DM. Uric Acid 48-57 insulin Homo sapiens 85-92
31923993-8 2020 The SnS2/GR-beta-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Uric Acid 147-156 ACD, shelterin complex subunit and telomerase recruitment factor Rattus norvegicus 12-19
32087742-3 2020 The aim of this study was to investigate in a population-based cohort (age range, 50-64 years) stratified by sex the association between the serum urate (SU) concentration and subclinical atherosclerosis, as reflected in the coronary artery calcification (CAC) score, common carotid intima-media thickness (CIMT), and carotid plaque score. Uric Acid 147-152 CIMT Homo sapiens 307-311
31841133-15 2020 CONCLUSIONS: This first GWAS of serum uric acid in continental Africans identified three associations at two loci, SLC2A9 and SLC22A12. Uric Acid 38-47 solute carrier family 2 member 9 Homo sapiens 115-121
32133013-12 2020 Finally, CLEC12A that recognizes monosodium urate crystals formed during cell death, inhibits activating signals to prevent detrimental inflammation. Uric Acid 33-49 C-type lectin domain family 12 member A Homo sapiens 9-16
31924495-3 2020 Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition receptors can be activated by uric acid crystallization, triggering immune inflammation and causing acute gouty arthritis symptoms. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 24-51
31924495-3 2020 Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition receptors can be activated by uric acid crystallization, triggering immune inflammation and causing acute gouty arthritis symptoms. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 53-58
32116724-11 2020 Therefore, our results reveal a novel mechanism whereby mangiferin can reduce serum uric acid levels by promoting AQP2-related urinary uric acid excretion. Uric Acid 84-93 aquaporin 2 Mus musculus 114-118
32116724-11 2020 Therefore, our results reveal a novel mechanism whereby mangiferin can reduce serum uric acid levels by promoting AQP2-related urinary uric acid excretion. Uric Acid 135-144 aquaporin 2 Mus musculus 114-118
31784090-2 2020 One such transporter, hMCT9, has been shown to be related to serum uric acid levels and the risk of renal overload gout. Uric Acid 67-76 solute carrier family 16 member 9 Homo sapiens 22-27
32047858-0 2020 Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate. Uric Acid 83-88 solute carrier family 22 member 12 Homo sapiens 104-109
32047858-0 2020 Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate. Uric Acid 83-88 solute carrier family 22 member 12 Homo sapiens 110-118
32047858-2 2020 Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. Uric Acid 118-123 solute carrier family 22 member 12 Homo sapiens 79-84
32047858-3 2020 We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases. Uric Acid 158-163 solute carrier family 22 member 12 Homo sapiens 58-63
32070295-0 2020 Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis. Uric Acid 0-9 microRNA 149 Mus musculus 71-78
32070295-0 2020 Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis. Uric Acid 0-9 fibroblast growth factor 21 Mus musculus 82-87
32070295-8 2020 Over-expression of miR-149-5p significantly aggregated uric acid-induced triglyceride accumulation in hepatocytes, while inhibiting miR-149-5p ameliorated the triglyceride accumulation. Uric Acid 55-64 microRNA 149 Mus musculus 19-26
32070295-10 2020 Silencing FGF21 abolished the ameliorative effects of miR-149-5p inhibitor on uric acid-induced hepatocytes lipid accumulation, while overexpression of FGF21 prevented the lipid accumulation induced by miR-149-5p mimics. Uric Acid 78-87 fibroblast growth factor 21 Mus musculus 10-15
32070295-10 2020 Silencing FGF21 abolished the ameliorative effects of miR-149-5p inhibitor on uric acid-induced hepatocytes lipid accumulation, while overexpression of FGF21 prevented the lipid accumulation induced by miR-149-5p mimics. Uric Acid 78-87 microRNA 149 Mus musculus 54-61
32070295-11 2020 CONCLUSIONS: Uric acid significantly up-regulated the expression of miR-149-5p in hepatocytes and induced hepatocytes lipid accumulation via regulation of miR-149-5p/FGF21 axis. Uric Acid 13-22 microRNA 149 Mus musculus 68-75
32070295-11 2020 CONCLUSIONS: Uric acid significantly up-regulated the expression of miR-149-5p in hepatocytes and induced hepatocytes lipid accumulation via regulation of miR-149-5p/FGF21 axis. Uric Acid 13-22 microRNA 149 Mus musculus 155-162
32070295-11 2020 CONCLUSIONS: Uric acid significantly up-regulated the expression of miR-149-5p in hepatocytes and induced hepatocytes lipid accumulation via regulation of miR-149-5p/FGF21 axis. Uric Acid 13-22 fibroblast growth factor 21 Mus musculus 166-171
32074508-0 2020 Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2. Uric Acid 0-9 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 108-114
32074508-0 2020 Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2. Uric Acid 0-9 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 124-129
32074508-6 2020 We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. Uric Acid 125-134 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 39-45
32074508-6 2020 We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. Uric Acid 125-134 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 52-57
32074508-6 2020 We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. Uric Acid 125-134 Heat shock transcription factor hsf-1 Caenorhabditis elegans 67-72
32074508-9 2020 Taken together, these data suggest that uric acid prolongs the life span of C. elegans, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1. Uric Acid 40-49 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 270-276
32074508-9 2020 Taken together, these data suggest that uric acid prolongs the life span of C. elegans, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1. Uric Acid 40-49 Heat shock transcription factor hsf-1 Caenorhabditis elegans 278-283
32074508-9 2020 Taken together, these data suggest that uric acid prolongs the life span of C. elegans, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1. Uric Acid 40-49 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 288-293
32041665-9 2020 Both partially reversed oxonate-induced alterations in renal mURAT-1, mGLUT-9, mOAT-1 and mOAT-3 expressions, as well as alterations in the immunoreactivity of TGF- beta1, resulting in the increase of renal uric acid secretion and excretion. Uric Acid 207-216 transforming growth factor, beta 1 Mus musculus 160-170
31931526-2 2020 Sodium-glucose cotransporter-2 (SGLT2) inhibitors prevent glucose reabsorption and lower serum uric acid levels. Uric Acid 95-104 solute carrier family 5 member 2 Homo sapiens 0-30
31931526-2 2020 Sodium-glucose cotransporter-2 (SGLT2) inhibitors prevent glucose reabsorption and lower serum uric acid levels. Uric Acid 95-104 solute carrier family 5 member 2 Homo sapiens 32-37
31836385-0 2020 Electrochemical determination of uric acid in urine and serum with uricase/carbon nanotube /carboxymethylcellulose electrode. Uric Acid 33-42 urate oxidase (pseudogene) Homo sapiens 67-74
31841133-15 2020 CONCLUSIONS: This first GWAS of serum uric acid in continental Africans identified three associations at two loci, SLC2A9 and SLC22A12. Uric Acid 38-47 solute carrier family 22 member 12 Homo sapiens 126-134
29657028-0 2020 Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy. Uric Acid 0-16 intercellular adhesion molecule 1 Homo sapiens 34-40
29657028-2 2020 MSU crystals can induce inflammatory events, we investigated the MSU-induced expression of intercellular adhesion molecule (ICAM)-1 on human renal mesangial cells (HRMCs) and the involved signal transduction mechanisms. Uric Acid 65-68 intercellular adhesion molecule 1 Homo sapiens 91-131
29657028-8 2020 RESULTS: MSU stimulation increased expression of ICAM-1 and adhesion between HRMCs and human monocytic THP-1 cells. Uric Acid 9-12 intercellular adhesion molecule 1 Homo sapiens 49-55
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 mitogen-activated protein kinase 8 Homo sapiens 83-106
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 mitogen-activated protein kinase 8 Homo sapiens 108-111
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 114-117
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 123-160
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 162-165
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 0-3 intercellular adhesion molecule 1 Homo sapiens 227-233
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 201-204 mitogen-activated protein kinase 1 Homo sapiens 123-160
29657028-10 2020 MSU stimulation induced activation of mitogen-activated protein kinases, including c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), but only p38 was responsible for MSU-induced expression of ICAM-1 and cell-cell adhesion. Uric Acid 201-204 intercellular adhesion molecule 1 Homo sapiens 227-233
29657028-11 2020 ASC also play a role in MSU-induced effects. Uric Acid 24-27 PYD and CARD domain containing Homo sapiens 0-3
29657028-12 2020 Pretreatment with monoclonal antibodies against toll-like receptor (TLR)2 or TLR4 reduced MSU-induced ICAM-1 expression, cell-cell adhesion, p38 phosphorylation but the reduction of ASC activation is insignificant. Uric Acid 90-93 toll like receptor 2 Homo sapiens 48-73
29657028-12 2020 Pretreatment with monoclonal antibodies against toll-like receptor (TLR)2 or TLR4 reduced MSU-induced ICAM-1 expression, cell-cell adhesion, p38 phosphorylation but the reduction of ASC activation is insignificant. Uric Acid 90-93 toll like receptor 4 Homo sapiens 77-81
29657028-12 2020 Pretreatment with monoclonal antibodies against toll-like receptor (TLR)2 or TLR4 reduced MSU-induced ICAM-1 expression, cell-cell adhesion, p38 phosphorylation but the reduction of ASC activation is insignificant. Uric Acid 90-93 intercellular adhesion molecule 1 Homo sapiens 102-108
29657028-12 2020 Pretreatment with monoclonal antibodies against toll-like receptor (TLR)2 or TLR4 reduced MSU-induced ICAM-1 expression, cell-cell adhesion, p38 phosphorylation but the reduction of ASC activation is insignificant. Uric Acid 90-93 mitogen-activated protein kinase 1 Homo sapiens 141-144
29657028-12 2020 Pretreatment with monoclonal antibodies against toll-like receptor (TLR)2 or TLR4 reduced MSU-induced ICAM-1 expression, cell-cell adhesion, p38 phosphorylation but the reduction of ASC activation is insignificant. Uric Acid 90-93 PYD and CARD domain containing Homo sapiens 182-185
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 intercellular adhesion molecule 1 Homo sapiens 28-34
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 toll like receptor 2 Homo sapiens 87-93
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 mitogen-activated protein kinase 1 Homo sapiens 94-97
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 intercellular adhesion molecule 1 Homo sapiens 98-103
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 toll like receptor 2 Homo sapiens 116-122
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 PYD and CARD domain containing Homo sapiens 135-138
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 mitogen-activated protein kinase 1 Homo sapiens 139-142
29657028-13 2020 CONCLUSION: The MSU induced ICAM-1 expression on HRMCs and cell-cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. Uric Acid 16-19 intercellular adhesion molecule 1 Homo sapiens 143-148
32083126-13 2020 This may be related to increased uric acid excretion and decreased uric acid production, mediated by renal OAT1, URAT1, liver XOD, and serum ADA. Uric Acid 67-76 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 107-111
32082152-10 2019 The results of cellular and molecular experiments showed that JSCBR can effectively reduce the protein expression of ASC, caspase-1, IL-1beta, and NRLP3 in monosodium urate-induced THP-1 cells, which indicated that JSCBR mediated inflammation in gouty arthritis by inhibiting the activation of NOD-like receptor signaling pathway. Uric Acid 156-172 PYD and CARD domain containing Homo sapiens 117-120
32082152-10 2019 The results of cellular and molecular experiments showed that JSCBR can effectively reduce the protein expression of ASC, caspase-1, IL-1beta, and NRLP3 in monosodium urate-induced THP-1 cells, which indicated that JSCBR mediated inflammation in gouty arthritis by inhibiting the activation of NOD-like receptor signaling pathway. Uric Acid 156-172 caspase 1 Homo sapiens 122-131
32082152-10 2019 The results of cellular and molecular experiments showed that JSCBR can effectively reduce the protein expression of ASC, caspase-1, IL-1beta, and NRLP3 in monosodium urate-induced THP-1 cells, which indicated that JSCBR mediated inflammation in gouty arthritis by inhibiting the activation of NOD-like receptor signaling pathway. Uric Acid 156-172 interleukin 1 alpha Homo sapiens 133-141
31873873-10 2020 Participants with a high serum E-selectin level had higher levels of hs-CRP, FBG, TG, uric acid, BMI and lower levels of serum HDL-C (p < 0.05). Uric Acid 86-95 selectin E Homo sapiens 31-41
32090094-9 2020 A few studies supported our results of the association between SLC16A9 and gout and serum urate levels. Uric Acid 90-95 solute carrier family 16 member 9 Homo sapiens 63-70
31994917-5 2020 Serum NGAL was also significantly related to serum ferritin, TIBC, uric acid, creatinine and blood sugar whereas, an inverse relationship with albumin, total cholesterol and LDL. Uric Acid 67-76 lipocalin 2 Homo sapiens 6-10
32000861-1 2020 BACKGROUND: Genetic background affects serum urate concentration and gout risk, especially regarding these variants in the urate-transporter gene ABCG2. Uric Acid 45-50 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 146-151
32000861-11 2020 CONCLUSION: Our findings indicate epistasis between PKD2 and ABCG2 influence serum urate concentrations, hyperuricemia and gout risk, thus providing insight into the pathogenesis of gout. Uric Acid 83-88 polycystin 2, transient receptor potential cation channel Homo sapiens 52-56
32000861-11 2020 CONCLUSION: Our findings indicate epistasis between PKD2 and ABCG2 influence serum urate concentrations, hyperuricemia and gout risk, thus providing insight into the pathogenesis of gout. Uric Acid 83-88 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 61-66
32021362-4 2020 The beneficial effects of SGLT2 inhibition extend beyond glycaemic control, and include improvement in blood pressure, body weight, uric acid concentrations, liver steatosis, oxidative stress, and inflammation. Uric Acid 132-141 solute carrier family 5 member 2 Homo sapiens 26-31
31979265-2 2020 These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis. Uric Acid 6-15 NLR family, pyrin domain containing 3 Mus musculus 38-85
31979265-2 2020 These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis. Uric Acid 6-15 NLR family, pyrin domain containing 3 Mus musculus 87-92
31979265-3 2020 This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo. Uric Acid 134-143 NLR family, pyrin domain containing 3 Mus musculus 180-185
31979265-4 2020 4-HAB dose-dependently reduced the release of interleukin (IL)-1beta, IL-18, active caspase-1 and apoptosis-associated speck-like protein (ASC) in uric acid crystals-activated macrophages. Uric Acid 147-156 caspase 1 Mus musculus 84-93
31979265-4 2020 4-HAB dose-dependently reduced the release of interleukin (IL)-1beta, IL-18, active caspase-1 and apoptosis-associated speck-like protein (ASC) in uric acid crystals-activated macrophages. Uric Acid 147-156 PYD and CARD domain containing Mus musculus 139-142
31594597-6 2020 Acceptable linear response of AA, DA, UA and AC respectively have been ranged 0.01-900.0 muM, 0.01-700.0 muM, 0.01-900.0 muM, and 0.01-900.0 muM with determination limits (S/N = 3) of 3.1 nM, 2.6 nM, 2.4 nM and 4.4 nM. Uric Acid 38-40 latexin Homo sapiens 89-92
31819009-9 2020 5 days post-administration, PAS800-IL-1Ra significantly reduced leukocyte influx and inflammatory markers in MSU-induced peritonitis, whereas equimolar anakinra administered 24 hours before MSU challenge was ineffective. Uric Acid 109-112 interleukin 1 receptor antagonist Mus musculus 35-41
31819009-10 2020 6-hour pretreatment with equimolar anakinra or PAS800-IL-1Ra before MSU challenge similarly reduced inflammatory markers. Uric Acid 68-71 interleukin 1 receptor antagonist Mus musculus 54-60
31965018-2 2020 Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. Uric Acid 80-89 xanthine dehydrogenase Mus musculus 30-46
31965018-2 2020 Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. Uric Acid 80-89 xanthine dehydrogenase Mus musculus 48-50
31965018-2 2020 Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. Uric Acid 91-93 xanthine dehydrogenase Mus musculus 30-46
31965018-2 2020 Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. Uric Acid 91-93 xanthine dehydrogenase Mus musculus 48-50
32010124-0 2019 Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk. Uric Acid 41-57 mitogen-activated protein kinase kinase kinase 7 Homo sapiens 140-144
32010124-0 2019 Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk. Uric Acid 41-57 spleen associated tyrosine kinase Homo sapiens 149-152
32010124-6 2019 We report for the first time that neutrophils can secrete the monocyte chemoattractant, CCL4, in response to MSU. Uric Acid 109-112 C-C motif chemokine ligand 4 Homo sapiens 88-92
32010124-7 2019 Accordingly, we found that transcription factors NF-kappaB, CREB, and C/EBP are belatedly activated by MSU crystals, and at least the former is involved in chemokine generation. Uric Acid 103-106 nuclear factor kappa B subunit 1 Homo sapiens 49-58
32010124-7 2019 Accordingly, we found that transcription factors NF-kappaB, CREB, and C/EBP are belatedly activated by MSU crystals, and at least the former is involved in chemokine generation. Uric Acid 103-106 cAMP responsive element binding protein 1 Homo sapiens 60-64
32010124-7 2019 Accordingly, we found that transcription factors NF-kappaB, CREB, and C/EBP are belatedly activated by MSU crystals, and at least the former is involved in chemokine generation. Uric Acid 103-106 CCAAT enhancer binding protein alpha Homo sapiens 70-75
31594597-6 2020 Acceptable linear response of AA, DA, UA and AC respectively have been ranged 0.01-900.0 muM, 0.01-700.0 muM, 0.01-900.0 muM, and 0.01-900.0 muM with determination limits (S/N = 3) of 3.1 nM, 2.6 nM, 2.4 nM and 4.4 nM. Uric Acid 38-40 latexin Homo sapiens 105-108
31594597-6 2020 Acceptable linear response of AA, DA, UA and AC respectively have been ranged 0.01-900.0 muM, 0.01-700.0 muM, 0.01-900.0 muM, and 0.01-900.0 muM with determination limits (S/N = 3) of 3.1 nM, 2.6 nM, 2.4 nM and 4.4 nM. Uric Acid 38-40 latexin Homo sapiens 105-108
31594597-6 2020 Acceptable linear response of AA, DA, UA and AC respectively have been ranged 0.01-900.0 muM, 0.01-700.0 muM, 0.01-900.0 muM, and 0.01-900.0 muM with determination limits (S/N = 3) of 3.1 nM, 2.6 nM, 2.4 nM and 4.4 nM. Uric Acid 38-40 latexin Homo sapiens 105-108
32933312-0 2020 Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways. Uric Acid 81-90 ATPase, class II, type 9A Mus musculus 34-37
31927516-9 2020 Also, urate increased the expression of c-Myc, an essential transcription factor for BCR-induced B-cell proliferation. Uric Acid 6-11 MYC proto-oncogene, bHLH transcription factor Homo sapiens 40-45
31941118-7 2020 To evaluate the possibility of using such a polymer coating in electroanalysis, HMT-PMBI-modified electrodes were utilized for the voltammetric detection of uric acid in artificial urine, Surine and ascorbic acid in Vitamin C samples. Uric Acid 157-166 histamine N-methyltransferase Homo sapiens 80-83
31941118-8 2020 The results showed that HMT-PMBI-coated electrodes can detect uric acid in Surine with a limit of detection (LoD) of 7.7 microM, sensitivity of 0.14 microA microM-1 cm-2, and linear range between 5 muM and 200 muM, whereas for Vitamin C tablets, the LoD is 41.4 microM, the sensitivity is 0.08 microA microM-1 cm-2, and the linear range is between 25 muM and 450 muM. Uric Acid 62-71 histamine N-methyltransferase Homo sapiens 24-27
31936416-2 2020 This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. Uric Acid 50-59 IGAN1 Homo sapiens 63-67
31936416-4 2020 We assessed the association of serum uric acid on IgAN progression using Kaplan-Meier survival analyses and Cox proportional hazards models. Uric Acid 37-46 IGAN1 Homo sapiens 50-54
31936416-7 2020 In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. Uric Acid 180-189 IGAN1 Homo sapiens 95-99
31936416-8 2020 The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (pinteraction < 0.001). Uric Acid 10-19 IGAN1 Homo sapiens 61-65
31936416-10 2020 In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men. Uric Acid 25-34 IGAN1 Homo sapiens 76-80
31093763-1 2020 AIMS: Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and generation of reactive oxygen species. Uric Acid 60-69 xanthine dehydrogenase Homo sapiens 6-29
31093763-1 2020 AIMS: Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and generation of reactive oxygen species. Uric Acid 60-69 xanthine dehydrogenase Homo sapiens 31-34
32933312-4 2020 Both EASM and Tan-IIA significantly decreased serum uric acid (SUA), serum creatinine (SCR), urine uric acid (UUA), and increased urine creatinine (UCR), and blood urea nitrogen (BUN) levels in experimental UAN mice. Uric Acid 52-61 ATPase, class II, type 9A Mus musculus 18-21
32933312-4 2020 Both EASM and Tan-IIA significantly decreased serum uric acid (SUA), serum creatinine (SCR), urine uric acid (UUA), and increased urine creatinine (UCR), and blood urea nitrogen (BUN) levels in experimental UAN mice. Uric Acid 99-108 ATPase, class II, type 9A Mus musculus 18-21
31676289-0 2020 MSU Crystals induce sterile IL-1beta secretion via P2X7 receptor activation and HMGB1 release. Uric Acid 0-3 interleukin 1 alpha Homo sapiens 28-36
31780526-0 2020 Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Uric Acid 79-88 solute carrier family 22 member 13 Homo sapiens 34-39
31780526-0 2020 Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Uric Acid 79-88 solute carrier family 22 member 13 Homo sapiens 40-48
31955613-0 2020 Association Between Electronic Cigarette Use and Levels of High-Sensitivity C-Reactive Protein and Uric Acid. Uric Acid 99-108 C-reactive protein Homo sapiens 76-94
31955613-5 2020 After adjusting for confounding factors, electronic cigarette use was significantly associated with elevated serum high-sensitivity C-reactive protein levels (beta = 1.326, P = .002), uric acid levels (beta = 0.400, P = .042), and hyperuricemia (uric acid level of >7 mg/mL; odds ratio = 2.67, 95% confidence interval = 1.27-5.58). Uric Acid 246-255 C-reactive protein Homo sapiens 132-150
31676289-0 2020 MSU Crystals induce sterile IL-1beta secretion via P2X7 receptor activation and HMGB1 release. Uric Acid 0-3 purinergic receptor P2X 7 Homo sapiens 51-64
31676289-0 2020 MSU Crystals induce sterile IL-1beta secretion via P2X7 receptor activation and HMGB1 release. Uric Acid 0-3 high mobility group box 1 Homo sapiens 80-85
31676289-2 2020 Few studies have shown that MSU is capable of stimulating the release of IL-1beta in the absence of LPS treatment. Uric Acid 28-31 interleukin 1 alpha Homo sapiens 73-81
31676289-4 2020 METHODS: We investigated the role of P2X7 receptor in sterile MSU-induced inflammation by evaluating peritonitis and paw edema. Uric Acid 62-65 purinergic receptor P2X 7 Homo sapiens 37-50
31676289-9 2020 In the in vitro model, we observed that MSU induced dye uptake by the P2X7 receptor. Uric Acid 40-43 purinergic receptor P2X 7 Homo sapiens 70-83
32378557-2 2020 Because uric acid and electrolytes are physiologically similar to blood glucose in renal excretion, we assessed predictors for the hypoglycemic effect of SGLT2 inhibitor treatment by focusing on serum uric acid and serum electrolytes. Uric Acid 201-210 solute carrier family 5 member 2 Homo sapiens 154-159
31676289-10 2020 In the absence of the receptor, or when it was blocked, MSU crystals induced less IL-1beta release and this effect corresponded to the concentration of extracellular ATP. Uric Acid 56-59 interleukin 1 alpha Homo sapiens 82-90
32378557-8 2020 Multiple linear regression analysis revealed that predictors of early response to SGLT2 inhibitors were serum uric acid values (p = 0.014) and baseline HbA1c (p < 0.001). Uric Acid 110-119 solute carrier family 5 member 2 Homo sapiens 82-87
32378557-9 2020 Furthermore, late response to SGLT2 inhibitors was associated with serum uric acid value (p = 0.047) and baseline HbA1c (p < 0.001). Uric Acid 73-82 solute carrier family 5 member 2 Homo sapiens 30-35
32378557-12 2020 Thus, this study showed that serum uric acid value is associated with the control of diabetes mellitus during SGLT2 inhibitor treatment. Uric Acid 35-44 solute carrier family 5 member 2 Homo sapiens 110-115
31676289-11 2020 Moreover, MSU treatment induced HMGB1 release; pre-treatment with P2X7 antagonist reduced the amount of HMGB1 in cell supernatants. Uric Acid 10-13 high mobility group box 1 Homo sapiens 32-37
31676289-11 2020 Moreover, MSU treatment induced HMGB1 release; pre-treatment with P2X7 antagonist reduced the amount of HMGB1 in cell supernatants. Uric Acid 10-13 high mobility group box 1 Homo sapiens 104-109
31676289-12 2020 CONCLUSIONS: IL-1beta secretion induced by MSU depends on P2X7 receptor activation and involves HMGB1 release. Uric Acid 43-46 interleukin 1 alpha Homo sapiens 13-21
31676289-12 2020 CONCLUSIONS: IL-1beta secretion induced by MSU depends on P2X7 receptor activation and involves HMGB1 release. Uric Acid 43-46 purinergic receptor P2X 7 Homo sapiens 58-71
33132325-1 2020 Xanthine and hypoxanthine are intermediate metabolites of uric acid and a source of reactive oxidative species (ROS) by xanthine oxidoreductase (XOR), suggesting that facilitating their elimination is beneficial. Uric Acid 58-67 xanthine dehydrogenase Rattus norvegicus 145-148
31676289-12 2020 CONCLUSIONS: IL-1beta secretion induced by MSU depends on P2X7 receptor activation and involves HMGB1 release. Uric Acid 43-46 high mobility group box 1 Homo sapiens 96-101
31676289-13 2020 GENERAL SIGNIFICANCE: We propose that cell activation caused by MSU crystals induces peritoneal macrophages and THP-1 cells to release ATP and HMGB1, causing IL-1beta secretion via P2X7 receptor activation. Uric Acid 64-67 high mobility group box 1 Homo sapiens 143-148
33132325-9 2020 It was suggested that xanthine is reabsorbed in the same manner as uric acid through URAT1 and GLUT9, while hypoxanthine is not. Uric Acid 67-76 solute carrier family 22 member 12 Canis lupus familiaris 85-90
31676289-13 2020 GENERAL SIGNIFICANCE: We propose that cell activation caused by MSU crystals induces peritoneal macrophages and THP-1 cells to release ATP and HMGB1, causing IL-1beta secretion via P2X7 receptor activation. Uric Acid 64-67 interleukin 1 alpha Homo sapiens 158-166
31676289-13 2020 GENERAL SIGNIFICANCE: We propose that cell activation caused by MSU crystals induces peritoneal macrophages and THP-1 cells to release ATP and HMGB1, causing IL-1beta secretion via P2X7 receptor activation. Uric Acid 64-67 purinergic receptor P2X 7 Homo sapiens 181-194
33132325-9 2020 It was suggested that xanthine is reabsorbed in the same manner as uric acid through URAT1 and GLUT9, while hypoxanthine is not. Uric Acid 67-76 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 95-100
33132325-0 2020 Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9. Uric Acid 32-41 solute carrier family 22 member 12 Canis lupus familiaris 64-69
30562825-5 2020 RESULTS: Multiple regression analyses adjusted for age, duration of diabetes, hemoglobin A1c, body mass index and log (serum creatinine) showed that serum UA level was significantly and negatively associated with uNTX in postmenopausal women with T2DM, whereas it was not associated with osteocalcin or BMD at each site. Uric Acid 155-157 bone gamma-carboxyglutamate protein Homo sapiens 288-299
33132325-0 2020 Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9. Uric Acid 32-41 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 74-79
32425684-3 2020 CXCR2 gene knocked out can avoid the acute neutrophilic inflammation stimulated by monosodium urate (MSU) crystals in mice. Uric Acid 83-99 chemokine (C-X-C motif) receptor 2 Mus musculus 0-5
32425684-3 2020 CXCR2 gene knocked out can avoid the acute neutrophilic inflammation stimulated by monosodium urate (MSU) crystals in mice. Uric Acid 101-104 chemokine (C-X-C motif) receptor 2 Mus musculus 0-5
32015688-7 2020 Furthermore, in both kidney and ileum, empagliflozin obviously promoted protein expression of uric acid (UA) transporter ABCG2, p-AMPK, p-AKT and p-CREB. Uric Acid 94-103 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 121-126
31221534-12 2020 The relationship of the Hp2-2 phenotype with the presence of plaques in the carotid was independent of age, gender, presence of risk factors (dyslipidaemia, hypertension and diabetes), the concentration of LDL-cholesterol, C-reactive protein and uric acid, blood pressure, and treatment with statins, and hypertensive drugs (OR: 1.31, 95%CI 1.01-1.70, P=.044). Uric Acid 246-255 ADP ribosylation factor like GTPase 6 interacting protein 5 Homo sapiens 24-29
32015688-7 2020 Furthermore, in both kidney and ileum, empagliflozin obviously promoted protein expression of uric acid (UA) transporter ABCG2, p-AMPK, p-AKT and p-CREB. Uric Acid 105-107 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 121-126
32176655-0 2020 Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson"s Disease: Data from the PPMI Study. Uric Acid 6-15 synuclein alpha Homo sapiens 71-86
32832488-6 2020 Molecular docking results showed that the highest binding affinity to uric acid belonged to uricase-PAS1-100 by the formation of six hydrogen and four non-hydrogen bonds. Uric Acid 70-79 urate oxidase (pseudogene) Homo sapiens 92-99
30868444-0 2020 Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. Uric Acid 26-35 insulin Homo sapiens 117-124
32176655-3 2020 OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. Uric Acid 75-84 synuclein alpha Homo sapiens 146-161
32176655-5 2020 Furthermore, we assessed baseline serum uric acid measurements of 24 p.A53T alpha-synuclein PD patients enrolled in PPMI and followed in our site as compared to 24 age-, gender- and disease duration-matched sporadic PD patients and 24 healthy controls. Uric Acid 40-49 synuclein alpha Homo sapiens 76-91
32176655-8 2020 The p.A53T SNCA mutation carrier PD group exhibited lower baseline serum uric acid level as compared to their matched healthy controls (p = 0.025). Uric Acid 73-82 synuclein alpha Homo sapiens 11-15
31745884-3 2020 Uric acid crystals activate synoviocytes culminating in the release of IL-1beta and neutrophil recruitment, key inflammatory elements in gouty arthritis. Uric Acid 0-9 interleukin 1 alpha Mus musculus 71-79
31790902-13 2020 CONCLUSIONS: Phloretin could effectively attenuate UA-induced renal injury via co-inhibiting NLRP3 and UA reabsorption, and thus it might be a potential therapy to hyperuricemia-related renal diseases. Uric Acid 51-53 NLR family, pyrin domain containing 3 Mus musculus 93-98
32552358-2 2020 The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1beta. Uric Acid 4-20 NLR family pyrin domain containing 3 Homo sapiens 86-91
32552358-2 2020 The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1beta. Uric Acid 4-20 interleukin 1 beta Homo sapiens 126-143
33132262-3 2020 In transporter-overexpressing cells, dotinurad potently inhibited URAT1 which is localized in the renal proximal tubules and functions as a urate reabsorption. Uric Acid 140-145 solute carrier family 22 member 12 Homo sapiens 66-71
32126884-7 2020 Moreover, urinary excretion of urate in high-HPRT/Uox-KO/Xor-KO mice means urate derived from gut microbiota is absorbed by the intestine. Uric Acid 31-36 hypoxanthine guanine phosphoribosyl transferase Mus musculus 45-49
32126884-7 2020 Moreover, urinary excretion of urate in high-HPRT/Uox-KO/Xor-KO mice means urate derived from gut microbiota is absorbed by the intestine. Uric Acid 31-36 urate oxidase Mus musculus 50-53
32646363-9 2020 Also, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1beta, as well as between Serum urate levels and hypertension severity. Uric Acid 53-58 C-reactive protein Homo sapiens 70-88
31705795-3 2020 The IL-1beta response to excess glucose was mediated by uric acid-induced activation of the NLRP3 inflammasome. Uric Acid 56-65 interleukin 1 alpha Homo sapiens 4-12
31705795-3 2020 The IL-1beta response to excess glucose was mediated by uric acid-induced activation of the NLRP3 inflammasome. Uric Acid 56-65 NLR family pyrin domain containing 3 Homo sapiens 92-97
31298290-0 2020 Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation. Uric Acid 0-16 interleukin 1 beta Mus musculus 25-42
31298290-0 2020 Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation. Uric Acid 0-16 toll-like receptor 4 Mus musculus 67-87
32646363-9 2020 Also, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1beta, as well as between Serum urate levels and hypertension severity. Uric Acid 53-58 interleukin 1 beta Homo sapiens 93-110
31504930-0 2020 Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation. Uric Acid 0-16 interleukin 1 beta Homo sapiens 25-42
31504930-0 2020 Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation. Uric Acid 0-16 toll like receptor 4 Homo sapiens 67-123
32082372-9 2019 Conclusions: Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. Uric Acid 335-344 insulin Homo sapiens 39-46
32386373-6 2020 Serum uric acid level was observed by the reaction with uricase. Uric Acid 6-15 urate oxidase (pseudogene) Homo sapiens 56-63
32120465-0 2019 Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka Introduction: Gamma-glutamyltransferase (GGT) and serum uric acid (UA) are known to be associated with cardiovascular disease in obese children Objectives: To determine the association of serum UA and GGT with components of metabolic syndrome (MetS) in a group of obese children and determine the validity of UA and GGT in predicting MetS. Uric Acid 21-30 sorcin Homo sapiens 145-148
32120465-0 2019 Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka Introduction: Gamma-glutamyltransferase (GGT) and serum uric acid (UA) are known to be associated with cardiovascular disease in obese children Objectives: To determine the association of serum UA and GGT with components of metabolic syndrome (MetS) in a group of obese children and determine the validity of UA and GGT in predicting MetS. Uric Acid 211-220 gamma-glutamyltransferase light chain family member 3 Homo sapiens 196-199
32082372-9 2019 Conclusions: Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. Uric Acid 335-344 insulin Homo sapiens 214-221
32082372-9 2019 Conclusions: Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. Uric Acid 335-344 xanthine dehydrogenase Homo sapiens 84-87
31877739-13 2019 The P6 peptide (10 and 25 muM) reduced ROS generation and IL-8 secretion mediated by a reduction in MSU phagocytosis by macrophages. Uric Acid 100-103 latexin Homo sapiens 26-29
31882798-4 2019 Dendritic cells and macrophages derived from murine bone marrow and human peripheral blood mononucleated cells stimulated with calcium-oxalate crystals, monosodium urate crystals, or ATP lead to the robust release of interleukin-1beta (IL-1ss). Uric Acid 153-169 interleukin 1 beta Homo sapiens 217-234
31949468-9 2019 The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde. Uric Acid 327-336 C-C motif chemokine ligand 4 Rattus norvegicus 17-21
31877739-10 2019 Cytotoxic effects of P6 peptide, colchicine, and colchicine-P6 peptide on macrophages were compared and the inhibition of ROS generation and interleukin-8 (IL-8) secretion in MSU-stimulated macrophages treated with P6 peptide, colchicine, or colchicine-P6 peptide was studied. Uric Acid 175-178 C-X-C motif chemokine ligand 8 Homo sapiens 141-154
31885496-6 2019 In addition, an increased level of TREM-1 was observed in THP-1 treated with monosodium urate (MSU) in vitro, along with upregulation of proinflammatory cytokines. Uric Acid 77-93 triggering receptor expressed on myeloid cells 1 Homo sapiens 35-41
31861421-9 2019 In addition, the CFH rs1065489G>T polymorphism is associated with homocysteine and prolactin level and CFH rs1061170 TC genotype is related to uric acid and triglycerides level in RPL patients. Uric Acid 143-152 complement factor H Homo sapiens 103-106
31920654-12 2019 The quassinoids isolated from EL showed inhibitory effects on urate uptake in hURAT1-expressing HEK293T cells, and the effect of eurycomanol was further confirmed in vivo. Uric Acid 62-67 solute carrier family 22 member 12 Homo sapiens 78-84
31818021-12 2019 We showed a significant reduction of serum uric acid (SUA) and C-reactive protein (CRP) in patients treated with LPD and inulin (p = 0.018 and p = 0.003, respectively), an improvement in SF-36 (physical role functioning and general health perceptions; p = 0.03 and p = 0.01, respectively), and a significant increase of serum bicarbonate both in patients treated with LPD (p = 0.026) or with LPD and inulin (p = 0.01). Uric Acid 43-52 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Homo sapiens 113-116
31885496-6 2019 In addition, an increased level of TREM-1 was observed in THP-1 treated with monosodium urate (MSU) in vitro, along with upregulation of proinflammatory cytokines. Uric Acid 95-98 triggering receptor expressed on myeloid cells 1 Homo sapiens 35-41
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 triggering receptor expressed on myeloid cells 1 Homo sapiens 38-44
31839921-1 2019 Background: Adenosine deaminase (ADA) regulates purine metabolism through the conversion of adenosine to uric acid (UA). Uric Acid 105-114 adenosine deaminase Homo sapiens 12-31
31839921-1 2019 Background: Adenosine deaminase (ADA) regulates purine metabolism through the conversion of adenosine to uric acid (UA). Uric Acid 105-114 adenosine deaminase Homo sapiens 33-36
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 toll like receptor 4 Homo sapiens 46-66
31839921-1 2019 Background: Adenosine deaminase (ADA) regulates purine metabolism through the conversion of adenosine to uric acid (UA). Uric Acid 116-118 adenosine deaminase Homo sapiens 12-31
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 toll like receptor 4 Homo sapiens 68-73
31839921-1 2019 Background: Adenosine deaminase (ADA) regulates purine metabolism through the conversion of adenosine to uric acid (UA). Uric Acid 116-118 adenosine deaminase Homo sapiens 33-36
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 MYD88 innate immune signal transduction adaptor Homo sapiens 80-113
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 MYD88 innate immune signal transduction adaptor Homo sapiens 115-120
31885496-7 2019 Moreover, upon specific inhibition of TREM-1, Toll-like receptor 4 (TLR-4), and myeloid differentiation factor 88 (MyD88), the levels of MyD88 and proinflammatory cytokines were decreased after MSU challenge in THP-1 cells. Uric Acid 194-197 MYD88 innate immune signal transduction adaptor Homo sapiens 137-142
31885496-8 2019 Interestingly, inhibition of TLR-4 could enhance the effect of TREM-1 inhibitor in MSU-induced inflammation. Uric Acid 83-86 toll like receptor 4 Homo sapiens 29-34
31885496-8 2019 Interestingly, inhibition of TLR-4 could enhance the effect of TREM-1 inhibitor in MSU-induced inflammation. Uric Acid 83-86 triggering receptor expressed on myeloid cells 1 Homo sapiens 63-69
31885496-9 2019 Taken together, our findings suggested that TREM-1 could accelerate MSU-induced acute inflammation. Uric Acid 68-71 triggering receptor expressed on myeloid cells 1 Homo sapiens 44-50
31297987-10 2019 Addition of either type II collagen or albumin also led to the formation of shorter MSU crystals. Uric Acid 84-87 albumin Homo sapiens 39-46
31297987-11 2019 In THP-1 cell assays, MSU crystals grown with healthy cartilage homogenate increased the release of interleukin-8, whereas MSU crystals grown with type II collagen or albumin had no effect on inflammatory cytokine release. Uric Acid 22-25 C-X-C motif chemokine ligand 8 Homo sapiens 100-113
30835642-8 2019 Serum uric acid level was positively correlated with glycan peaks (GP)1, GP2, GP4, GP6, GP10, and GP11, whereas it was negatively correlated with GP12, GP13, GP14, GP15, GP18, and GP20. Uric Acid 6-15 glycoprotein 2 Homo sapiens 73-76
31478104-1 2019 BACKGROUND: The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1. Uric Acid 103-112 solute carrier family 22 member 12 Homo sapiens 16-35
31478104-1 2019 BACKGROUND: The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1. Uric Acid 103-112 solute carrier family 22 member 12 Homo sapiens 37-42
31478104-1 2019 BACKGROUND: The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1. Uric Acid 103-112 solute carrier family 22 member 12 Homo sapiens 218-226
31478104-1 2019 BACKGROUND: The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1. Uric Acid 103-112 solute carrier family 22 member 12 Homo sapiens 241-246
31559872-0 2019 Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis. Uric Acid 0-9 maternally expressed 3 Homo sapiens 99-103
31559872-0 2019 Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis. Uric Acid 0-9 microRNA 7-3 Homo sapiens 104-112
31559872-0 2019 Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis. Uric Acid 0-9 epidermal growth factor receptor Homo sapiens 113-117
31559872-6 2019 The combination of UA and SM treatment could promote autophagy and inhibit EGFR and AKT3 expressions. Uric Acid 19-21 epidermal growth factor receptor Homo sapiens 75-79
31559872-6 2019 The combination of UA and SM treatment could promote autophagy and inhibit EGFR and AKT3 expressions. Uric Acid 19-21 AKT serine/threonine kinase 3 Homo sapiens 84-88
31559872-7 2019 Overexpression of EGFR and AKT3 suppressed autophagy in UA and SM-treated cardiomyocytes, respectively. Uric Acid 56-58 epidermal growth factor receptor Homo sapiens 18-22
31559872-7 2019 Overexpression of EGFR and AKT3 suppressed autophagy in UA and SM-treated cardiomyocytes, respectively. Uric Acid 56-58 AKT serine/threonine kinase 3 Homo sapiens 27-31
31559872-8 2019 Also, lncRNA MEG3 knockdown and overexpression could enhance and inhibit autophagy in UA and SM-treated cardiomyocytes, respectively, through targeting miR-7-5p. Uric Acid 86-88 maternally expressed 3 Homo sapiens 13-17
31559872-9 2019 Moreover, miR-7-5p mimics and inhibitors promoted and inhibited autophagy in UA and SM-treated cardiomyocytes, respectively, via target EGFR. Uric Acid 77-79 microRNA 7-3 Homo sapiens 10-18
31559872-9 2019 Moreover, miR-7-5p mimics and inhibitors promoted and inhibited autophagy in UA and SM-treated cardiomyocytes, respectively, via target EGFR. Uric Acid 77-79 epidermal growth factor receptor Homo sapiens 136-140
31559872-10 2019 In VSD rat model, upregulation of MEG3 could reverse high level of autophagy and decrease serum UA and SM. Uric Acid 96-98 similar to GTL2, imprinted maternally expressed untranslated Rattus norvegicus 34-38
30835642-8 2019 Serum uric acid level was positively correlated with glycan peaks (GP)1, GP2, GP4, GP6, GP10, and GP11, whereas it was negatively correlated with GP12, GP13, GP14, GP15, GP18, and GP20. Uric Acid 6-15 CD36 molecule Homo sapiens 78-81
30835642-8 2019 Serum uric acid level was positively correlated with glycan peaks (GP)1, GP2, GP4, GP6, GP10, and GP11, whereas it was negatively correlated with GP12, GP13, GP14, GP15, GP18, and GP20. Uric Acid 6-15 glycoprotein VI platelet Homo sapiens 83-86
30835642-8 2019 Serum uric acid level was positively correlated with glycan peaks (GP)1, GP2, GP4, GP6, GP10, and GP11, whereas it was negatively correlated with GP12, GP13, GP14, GP15, GP18, and GP20. Uric Acid 6-15 S100 calcium binding protein A10 Homo sapiens 98-102
31819864-8 2019 Results: CPPD and MSU activate caspase-1 in urothelial cells in a dose-dependent manner, reaching ~50% and ~25% of the ATP response, respectively. Uric Acid 18-21 caspase 1 Homo sapiens 31-40
31819864-0 2019 Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP. Uric Acid 26-42 NLR family pyrin domain containing 3 Homo sapiens 56-61
31819864-0 2019 Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP. Uric Acid 26-42 thioredoxin interacting protein Homo sapiens 133-138
31819864-11 2019 Conclusion: The stone components CPPD and MSU activate NLRP3 in an ROS and TXNIP-dependent manner in bladder urothelium. Uric Acid 42-45 NLR family pyrin domain containing 3 Homo sapiens 55-60
31819864-11 2019 Conclusion: The stone components CPPD and MSU activate NLRP3 in an ROS and TXNIP-dependent manner in bladder urothelium. Uric Acid 42-45 thioredoxin interacting protein Homo sapiens 75-80
31675031-0 2019 Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum. Uric Acid 108-117 urate oxidase (pseudogene) Homo sapiens 0-7
31819564-4 2019 Results: AST/ALT was negatively correlated with waist circumference (WC), waist-to-hip ratio, body mass index (BMI), diastolic blood pressure, triglycerides, low-density lipoprotein, uric acid, fasting insulin, and insulin resistance. Uric Acid 183-192 solute carrier family 17 member 5 Homo sapiens 9-12
31803174-3 2019 MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Uric Acid 0-3 NLR family, pyrin domain containing 3 Mus musculus 24-29
31803174-3 2019 MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Uric Acid 0-3 caspase 1 Mus musculus 73-82
31803174-3 2019 MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Uric Acid 0-3 interleukin 1 beta Mus musculus 101-109
31803174-3 2019 MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Uric Acid 0-3 interleukin 18 Mus musculus 114-119
31675031-1 2019 Based on the unique property of preferential sequestration of guest molecules, coacervate microdroplets are proposed as enzyme active membrane-free protocells, in which uricase is loaded for efficient detoxification of uric acid in serum. Uric Acid 219-228 urate oxidase (pseudogene) Homo sapiens 169-176
31707403-0 2019 Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. Uric Acid 9-18 NLR family pyrin domain containing 3 Homo sapiens 120-125
31707403-2 2019 Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC). Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 40-67
31707403-0 2019 Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. Uric Acid 9-18 NLR family pyrin domain containing 3 Homo sapiens 91-118
31707403-2 2019 Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC). Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 69-74
31707403-8 2019 RESULTS The results showed that uric acid increases the proliferation of VSMC and induces alpha-SMA accumulation. Uric Acid 32-41 actin alpha 1, skeletal muscle Homo sapiens 90-99
31707403-9 2019 We also found that uric acid increases the level of NLRP3 and induces NLRP3-inflammasome activation. Uric Acid 19-28 NLR family pyrin domain containing 3 Homo sapiens 52-57
31707403-9 2019 We also found that uric acid increases the level of NLRP3 and induces NLRP3-inflammasome activation. Uric Acid 19-28 NLR family pyrin domain containing 3 Homo sapiens 70-75
31707403-10 2019 The expressions of uric acid-induced inflammatory markers IL-1ss and IL-18 were decreased by the inhibitor MCC950. Uric Acid 19-28 interleukin 18 Homo sapiens 69-74
31707403-11 2019 CONCLUSIONS Our findings revealed that uric acid induces inflammation through NLRP3-inflammasome-mediated VSMC proliferation. Uric Acid 39-48 NLR family pyrin domain containing 3 Homo sapiens 78-83
31367941-7 2019 RESULTS: Sirt1 agonist significantly suppressed the onset of gouty arthritis induced by MSU and reduced the infiltration of inflammatory cells in the joints. Uric Acid 88-91 sirtuin 1 Mus musculus 9-14
31703439-0 2019 Polydatin and Resveratrol Inhibit the Inflammatory Process Induced by Urate and Pyrophosphate Crystals in THP-1 Cells. Uric Acid 70-75 GLI family zinc finger 2 Homo sapiens 106-111
33693087-5 2019 Soluble UA accumulates intracellularly through UA transporters (UAT), shortening the atrial action potential via enhanced expression and activity of Kv1.5 channel proteins. Uric Acid 8-10 potassium voltage-gated channel subfamily A member 5 Homo sapiens 149-154
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 dual oxidase 2 Homo sapiens 78-129
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 mitogen-activated protein kinase 1 Homo sapiens 152-155
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 AKT serine/threonine kinase 1 Homo sapiens 156-159
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 heat shock transcription factor 1 Homo sapiens 164-183
31882426-3 2019 Urate transporter 1 (URAT1) is a major urate transporter involved in renal uric acid reabsorption and excretion, making it an important anti-HUA drug target. Uric Acid 75-84 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 0-19
31882426-3 2019 Urate transporter 1 (URAT1) is a major urate transporter involved in renal uric acid reabsorption and excretion, making it an important anti-HUA drug target. Uric Acid 75-84 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 21-26
31882426-8 2019 Based on these in vivo findings, we propose that extracellular uric acid levels in the proximal tubule epithelial cells positively regulated URAT1 expression. Uric Acid 63-72 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 141-146
31882426-9 2019 In high uric acid cell models, URAT1 expression increased within 2 h of uric acid stimulation in a dose-dependent manner that supported our hypothesis. Uric Acid 8-17 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 31-36
31882426-9 2019 In high uric acid cell models, URAT1 expression increased within 2 h of uric acid stimulation in a dose-dependent manner that supported our hypothesis. Uric Acid 72-81 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 31-36
31882426-10 2019 Therefore, our results suggest that URAT1 expression is positively regulated by the distinct extracellular uric acid levels in different HUA models. Uric Acid 107-116 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 36-41
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 heat shock transcription factor 1 Homo sapiens 185-189
33693087-6 2019 Intracellular accumulation of soluble UA generates ROS in atrial myocytes via nicotinamide adenine dinucleotide phosphate oxidase, which phosphorylates ERK/Akt and heat shock factor 1 (HSF1), thereby increasing transcription and translation of Hsp70, which stabilizes Kv1.5. Uric Acid 38-40 potassium voltage-gated channel subfamily A member 5 Homo sapiens 268-273
33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 NLR family pyrin domain containing 3 Homo sapiens 34-39
33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 caspase 1 Homo sapiens 92-101
33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 interleukin 1 alpha Homo sapiens 116-138
33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 interleukin 18 Homo sapiens 143-148
31542837-13 2019 This study demonstrated that IgAN patients with NS had higher serum creatine, lower eGFR, lower uric acid, more acute lesions and poor prognosis. Uric Acid 96-105 IGAN1 Homo sapiens 29-33
31367941-8 2019 Sirt1 agonist significantly promoted the expression of PPARgamma, while decreased the expression of interleukin (IL)-1beta, IL-1alpha, IL-6, interferon-gamma (IFN-gamma), monocyte chemotactic protein 1(MCP-1), tumor necrosis factor a (TNF-alpha), and chemokines (CXCL-1, CXCL-5, CCL-22) induced by MSU in joint tissues. Uric Acid 298-301 sirtuin 1 Mus musculus 0-5
31367941-12 2019 Sirt1 inhibits the infiltration of inflammatory cells and the secretion of pro-inflammatory molecules in MSU-induced arthritis. Uric Acid 105-108 sirtuin 1 Mus musculus 0-5
31519697-0 2019 Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1. Uric Acid 44-49 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 77-96
31556223-1 2019 Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol and febuxostat, inhibit the catalysis of serum uric acid (SUA) synthesis. Uric Acid 109-118 xanthine dehydrogenase Homo sapiens 0-23
31593642-1 2019 Introduction: Human urate transporter 1 (URAT1), which is an influx transporter protein, is located at the apical surface of renal tubular cells and presumed to be the major transporter responsible for the reabsorption of urate from blood. Uric Acid 20-25 solute carrier family 22 member 12 Homo sapiens 41-46
31593642-2 2019 About 90% of patients develop hyperuricemia due to insufficient urate excretion; thus, it is important to develop URAT1 inhibitors that could enhance renal urate excretion by blocking the reabsorption of urate anion. Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 114-119
31593642-2 2019 About 90% of patients develop hyperuricemia due to insufficient urate excretion; thus, it is important to develop URAT1 inhibitors that could enhance renal urate excretion by blocking the reabsorption of urate anion. Uric Acid 156-161 solute carrier family 22 member 12 Homo sapiens 114-119
31496508-2 2019 Xanthine oxidoreductase (XOR) inhibitors inhibit uric acid (UA) production and may be treatment options for hyperuricemia patients. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 0-23
31496508-2 2019 Xanthine oxidoreductase (XOR) inhibitors inhibit uric acid (UA) production and may be treatment options for hyperuricemia patients. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 25-28
31496508-2 2019 Xanthine oxidoreductase (XOR) inhibitors inhibit uric acid (UA) production and may be treatment options for hyperuricemia patients. Uric Acid 60-62 xanthine dehydrogenase Homo sapiens 0-23
31496508-2 2019 Xanthine oxidoreductase (XOR) inhibitors inhibit uric acid (UA) production and may be treatment options for hyperuricemia patients. Uric Acid 60-62 xanthine dehydrogenase Homo sapiens 25-28
31165340-2 2019 Catechol-O-methyltransferase (COMT) regulates dopamine activity and metabolism, thereby participating in the uric acid metabolism, which in turn affects the occurrence of gout. Uric Acid 109-118 catechol-O-methyltransferase Homo sapiens 0-28
33575564-7 2020 A remarkable example is the uric acid-degrading enzyme UOX, which we found to be inactivated in elephants and manatees. Uric Acid 28-37 urate oxidase (pseudogene) Homo sapiens 55-58
33575564-8 2020 While UOX loss in hominoids led to high serum uric acid levels and a predisposition for gout, elephants and manatees exhibit low uric acid levels, suggesting alternative ways of metabolizing uric acid. Uric Acid 46-55 urate oxidase (pseudogene) Homo sapiens 6-9
31649546-9 2019 Allopurinol, an inhibitor of uric acid production, has been shown to decrease renal inflammation by limiting activation of the NLRP3 inflammasome. Uric Acid 29-38 NLR family pyrin domain containing 3 Homo sapiens 127-132
31056705-0 2019 URC102, a potent and selective inhibitor of hURAT1, reduced serum uric acid in healthy volunteers. Uric Acid 66-75 solute carrier family 22 member 12 Homo sapiens 44-50
31056705-1 2019 OBJECTIVE: URC102, a novel and potent inhibitor of human uric acid transporter 1 (hURAT1), is currently under clinical development to treat patients with gout. Uric Acid 57-66 solute carrier family 22 member 12 Homo sapiens 82-88
31695625-3 2019 Genetic variation in the SLC2A9 gene, encoding the urate transporter GLUT9, exerts the largest single-gene effect on serum uric acid (SUA). Uric Acid 123-132 solute carrier family 2 member 9 Homo sapiens 25-31
31695625-3 2019 Genetic variation in the SLC2A9 gene, encoding the urate transporter GLUT9, exerts the largest single-gene effect on serum uric acid (SUA). Uric Acid 123-132 solute carrier family 2 member 9 Homo sapiens 69-74
31597297-1 2019 The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Uric Acid 83-92 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 10-15
31607026-14 2019 After one year of uric acid-reducing treatment, the levels of urinary RBP, beta(2)-MG and NAG were lower than that before treatment. Uric Acid 18-27 retinol binding protein 4 Homo sapiens 70-73
31607026-14 2019 After one year of uric acid-reducing treatment, the levels of urinary RBP, beta(2)-MG and NAG were lower than that before treatment. Uric Acid 18-27 NBAS subunit of NRZ tethering complex Homo sapiens 90-93
31607026-16 2019 Compared with group C, the levels of urinary beta(2)-MG and NAG were decreased in group B after uric acid-reducing treatment (all P<0.05). Uric Acid 96-105 NBAS subunit of NRZ tethering complex Homo sapiens 60-63
31364377-0 2019 Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. Uric Acid 77-86 septin interacting protein 1 Drosophila melanogaster 63-67
31364377-9 2019 Knockdown of NHE2 specifically to the stellate cells also increased renal uric acid stone formation, and so a model was developed in which SIP1 normally regulates NHE2 activity and luminal pH, ultimately leading to uric acid stone formation. Uric Acid 74-83 Na[+]/H[+] hydrogen exchanger 2 Drosophila melanogaster 13-17
31364377-9 2019 Knockdown of NHE2 specifically to the stellate cells also increased renal uric acid stone formation, and so a model was developed in which SIP1 normally regulates NHE2 activity and luminal pH, ultimately leading to uric acid stone formation. Uric Acid 215-224 Na[+]/H[+] hydrogen exchanger 2 Drosophila melanogaster 13-17
31364377-9 2019 Knockdown of NHE2 specifically to the stellate cells also increased renal uric acid stone formation, and so a model was developed in which SIP1 normally regulates NHE2 activity and luminal pH, ultimately leading to uric acid stone formation. Uric Acid 215-224 SLC9A3 regulator 2 Homo sapiens 139-143
31289104-8 2019 Comparing ORs for each locus in the present versus the previous GWAS revealed three "gout vs AHUA GWAS"-specific loci (CNTN5, MIR302F and ZNF724) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. Uric Acid 290-299 contactin 5 Homo sapiens 119-124
31289104-8 2019 Comparing ORs for each locus in the present versus the previous GWAS revealed three "gout vs AHUA GWAS"-specific loci (CNTN5, MIR302F and ZNF724) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. Uric Acid 290-299 microRNA 302f Homo sapiens 126-133
31289104-8 2019 Comparing ORs for each locus in the present versus the previous GWAS revealed three "gout vs AHUA GWAS"-specific loci (CNTN5, MIR302F and ZNF724) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. Uric Acid 290-299 zinc finger protein 724 Homo sapiens 138-144
31165340-2 2019 Catechol-O-methyltransferase (COMT) regulates dopamine activity and metabolism, thereby participating in the uric acid metabolism, which in turn affects the occurrence of gout. Uric Acid 109-118 catechol-O-methyltransferase Homo sapiens 30-34
31268920-0 2019 Association of the ESR1 polymorphism with menopause and MLXIPL genetic variant influence serum uric acid levels in Slovak midlife women. Uric Acid 95-104 estrogen receptor 1 Homo sapiens 19-23
30372763-9 2019 Spearman"s correlation analysis showed that serum periostin levels had a positive correlation with body mass index (BMI), uric acid, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitive C reactive protein (hs-CRP), and a negative correlation with insulin sensitivity index (ISI). Uric Acid 122-131 periostin Homo sapiens 50-59
31616405-11 2019 DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum. Uric Acid 138-154 interleukin 1 beta Mus musculus 69-77
31296606-5 2019 RESULTS: Crystals of calcium oxalate, monosodium urate, or calcium pyrophosphate dihydrate, as well as silica microparticles, triggered cell necrosis involving PPIF-dependent mitochondrial permeability transition. Uric Acid 38-54 peptidylprolyl isomerase F (cyclophilin F) Mus musculus 160-164
31302317-9 2019 In mice, obovatol attenuated serum IL-1beta elevation in response to monosodium urate crystals. Uric Acid 69-85 interleukin 1 alpha Mus musculus 35-43
31363829-0 2019 Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors. Uric Acid 6-15 tumor necrosis factor Homo sapiens 115-118
31357262-9 2019 In patients with a GFR < 60 mL/min/1.73 m2, uric acid levels correlated positively with the PRF thickness (P < 0.05). Uric Acid 47-56 CD59 molecule (CD59 blood group) Homo sapiens 34-39
31378369-0 2019 MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells. Uric Acid 44-53 solute carrier family 2 member 9 Homo sapiens 28-33
31378369-1 2019 GLUT9 is generally considered to be associated with the uric acid transport, which plays an important role in the regulation of serum uric acid level. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 0-5
31378369-1 2019 GLUT9 is generally considered to be associated with the uric acid transport, which plays an important role in the regulation of serum uric acid level. Uric Acid 134-143 solute carrier family 2 member 9 Homo sapiens 0-5
31378369-7 2019 In conclusion, miR-143-3p can reduce uric acid reabsorption by inhibiting its downstream target gene GLUT9. Uric Acid 37-46 solute carrier family 2 member 9 Homo sapiens 101-106
31268920-0 2019 Association of the ESR1 polymorphism with menopause and MLXIPL genetic variant influence serum uric acid levels in Slovak midlife women. Uric Acid 95-104 MLX interacting protein like Homo sapiens 56-62
31268920-9 2019 RESULTS: A positive association between MLXIPL and UA level was observed in the total sample of women after control for confounding covariates, including FM, TGs, and creatinine (P = 0.027). Uric Acid 51-53 MLX interacting protein like Homo sapiens 40-46
31130575-1 2019 Xanthine oxidoreductase (XOR), an enzyme of uric acid formation from hypoxanthine and xanthine, is recognized as a source of oxidative stress. Uric Acid 44-53 xanthine dehydrogenase Homo sapiens 0-23
31130575-1 2019 Xanthine oxidoreductase (XOR), an enzyme of uric acid formation from hypoxanthine and xanthine, is recognized as a source of oxidative stress. Uric Acid 44-53 xanthine dehydrogenase Homo sapiens 25-28
31130575-3 2019 We investigated longitudinal change in plasma XOR activity, which was determined by using mass spectrometry and liquid chromatography to detect [13C2, 15N2]-uric acid using [13C2, 15N2]-xanthine as a substrate, in 511 subjects (male/female: 244/267) of the Tanno-Sobetsu Study in the years 2016 and 2017. Uric Acid 157-166 xanthine dehydrogenase Homo sapiens 46-49
31616405-11 2019 DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum. Uric Acid 138-154 interleukin 1 alpha Mus musculus 82-91
31540400-6 2019 Total antioxidant potential was determined spectrophotometrically using the FRAP method (ferric ion reducing antioxidant parameter) by measuring total FRAP and uric acid (UA)-independent FRAP (FRAP-UA). Uric Acid 160-169 mechanistic target of rapamycin kinase Homo sapiens 76-80
31540400-6 2019 Total antioxidant potential was determined spectrophotometrically using the FRAP method (ferric ion reducing antioxidant parameter) by measuring total FRAP and uric acid (UA)-independent FRAP (FRAP-UA). Uric Acid 160-169 mechanistic target of rapamycin kinase Homo sapiens 193-200
31540400-6 2019 Total antioxidant potential was determined spectrophotometrically using the FRAP method (ferric ion reducing antioxidant parameter) by measuring total FRAP and uric acid (UA)-independent FRAP (FRAP-UA). Uric Acid 171-173 mechanistic target of rapamycin kinase Homo sapiens 76-80
31358323-11 2019 Artemisinin (10 and 100 muM) attenuated intracellular K+ efflux in macrophages stimulated with LPS and MSU crystals. Uric Acid 103-106 latexin Homo sapiens 24-27
31358323-0 2019 Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Uric Acid 43-52 NLR family pyrin domain containing 3 Homo sapiens 61-66
31358323-13 2019 CONCLUSION: This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation. Uric Acid 145-154 NLR family pyrin domain containing 3 Homo sapiens 73-78
31358323-0 2019 Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Uric Acid 43-52 NLR family pyrin domain containing 3 Homo sapiens 128-133
31358323-13 2019 CONCLUSION: This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation. Uric Acid 145-154 NIMA related kinase 7 Homo sapiens 127-131
31358323-0 2019 Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Uric Acid 43-52 NIMA related kinase 7 Homo sapiens 138-142
31358323-3 2019 The aim of this study was to clarify the anti-inflammatory effect of artemisinin on activation of uric acid-induced NLRP3 inflammasome through regulation of NEK7. Uric Acid 98-107 NLR family pyrin domain containing 3 Homo sapiens 116-121
31358323-3 2019 The aim of this study was to clarify the anti-inflammatory effect of artemisinin on activation of uric acid-induced NLRP3 inflammasome through regulation of NEK7. Uric Acid 98-107 NIMA related kinase 7 Homo sapiens 157-161
31358323-9 2019 Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM). Uric Acid 111-114 NLR family pyrin domain containing 3 Homo sapiens 23-28
31358323-9 2019 Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM). Uric Acid 111-114 caspase 1 Homo sapiens 30-39
31358323-13 2019 CONCLUSION: This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation. Uric Acid 145-154 NLR family pyrin domain containing 3 Homo sapiens 136-141
31512001-6 2019 This hypothesis was supported by the metabolome analysis which revealed that concentration of histamine and other dermatitis-associated metabolites like urate and serotonin in the dermatitis skin, but not normal skin, of Mdr1a/1b/Bcrp-/- mice was higher than that of wild-type mice. Uric Acid 153-158 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 230-234
31358323-9 2019 Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM). Uric Acid 111-114 interleukin 1 beta Homo sapiens 45-53
31358323-9 2019 Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM). Uric Acid 111-114 latexin Homo sapiens 213-216
31233985-6 2019 The detection of NSE, relied on its obstruction in analytical signal observed for the photo-oxidation of UA after binding to the electrode surface via protein-antibody interaction. Uric Acid 105-107 enolase 2 Homo sapiens 17-20
31489932-10 2019 Therefore, our findings enable the preliminarily conclusion that EDG-50 lowers serum uric acid concentrations, mainly by down-regulating the expression of GLUT9 and URAT1 proteins and up-regulating the expression of OAT1 proteins. Uric Acid 85-94 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 165-170
31356840-4 2019 Urate oxidase (UOX) is a therapeutic enzyme that catalyzes the conversion of uric acid (UA) into a soluble metabolite, and it is used clinically for the treatment of hyperuricemia. Uric Acid 77-86 urate oxidase (pseudogene) Homo sapiens 15-18
31356840-4 2019 Urate oxidase (UOX) is a therapeutic enzyme that catalyzes the conversion of uric acid (UA) into a soluble metabolite, and it is used clinically for the treatment of hyperuricemia. Uric Acid 88-90 urate oxidase (pseudogene) Homo sapiens 0-13
31356840-4 2019 Urate oxidase (UOX) is a therapeutic enzyme that catalyzes the conversion of uric acid (UA) into a soluble metabolite, and it is used clinically for the treatment of hyperuricemia. Uric Acid 88-90 urate oxidase (pseudogene) Homo sapiens 15-18
31356840-5 2019 Since UA degradation by UOX generates H2O2 (a cytotoxic side product), UOX was co-delivered with catalase-mimic nanoparticles (AuNPs) using biocompatible pluronic-based nanocarriers (NCs) to effectively reduce H2O2-associated toxicity in cultured cells and to enhance UA degradation efficiency in vivo. Uric Acid 6-8 urate oxidase (pseudogene) Homo sapiens 24-27
31356840-5 2019 Since UA degradation by UOX generates H2O2 (a cytotoxic side product), UOX was co-delivered with catalase-mimic nanoparticles (AuNPs) using biocompatible pluronic-based nanocarriers (NCs) to effectively reduce H2O2-associated toxicity in cultured cells and to enhance UA degradation efficiency in vivo. Uric Acid 6-8 urate oxidase (pseudogene) Homo sapiens 71-74
31356840-5 2019 Since UA degradation by UOX generates H2O2 (a cytotoxic side product), UOX was co-delivered with catalase-mimic nanoparticles (AuNPs) using biocompatible pluronic-based nanocarriers (NCs) to effectively reduce H2O2-associated toxicity in cultured cells and to enhance UA degradation efficiency in vivo. Uric Acid 268-270 urate oxidase (pseudogene) Homo sapiens 71-74
31356840-5 2019 Since UA degradation by UOX generates H2O2 (a cytotoxic side product), UOX was co-delivered with catalase-mimic nanoparticles (AuNPs) using biocompatible pluronic-based nanocarriers (NCs) to effectively reduce H2O2-associated toxicity in cultured cells and to enhance UA degradation efficiency in vivo. Uric Acid 268-270 catalase Homo sapiens 97-105
31356840-7 2019 Co-localizing UOX and AuNPs in the NCs led to enhanced UA degradation and H2O2 removal in vitro, leading to a great reduction in H2O2-associated cytotoxicity compared with UOX alone or a free mixture of UOX and AuNPs. Uric Acid 55-57 urate oxidase (pseudogene) Homo sapiens 14-17
31356840-4 2019 Urate oxidase (UOX) is a therapeutic enzyme that catalyzes the conversion of uric acid (UA) into a soluble metabolite, and it is used clinically for the treatment of hyperuricemia. Uric Acid 77-86 urate oxidase (pseudogene) Homo sapiens 0-13
31491937-7 2019 UA also inhibits vitamin D production and thereby results in hyper-parathyroidism, which causes less UA excretion in the intestines and renal proximal tubules by inhibiting the urate transporter ATP-binding cassette subfamily G member 2 (ABCG2). Uric Acid 0-2 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 238-243
31392775-6 2019 Injection of MSU crystals induced massive accumulation of neutrophils expressing phosphorylated Akt. Uric Acid 13-16 thymoma viral proto-oncogene 1 Mus musculus 96-99
31451663-4 2019 Clec12A detects uric acid crystals and limits proinflammatory pathways by counteracting the cell-activating spleen tyrosine kinase (Syk). Uric Acid 16-25 C-type lectin domain family 12 member A Homo sapiens 0-7
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 87-103 DExD/H-box helicase 58 Homo sapiens 6-36
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 87-103 DExD/H-box helicase 58 Homo sapiens 38-43
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 87-103 C-type lectin domain family 12 member A Homo sapiens 129-136
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 105-108 DExD/H-box helicase 58 Homo sapiens 6-36
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 105-108 DExD/H-box helicase 58 Homo sapiens 38-43
31451663-6 2019 Using retinoic acid-inducible gene I (RIG-I) signaling as a model, we demonstrate that monosodium urate (MSU) crystal sensing by Clec12A enhances cytosolic RNA-induced IFN-I production and the subsequent induction of IFN-I-stimulated genes. Uric Acid 105-108 C-type lectin domain family 12 member A Homo sapiens 129-136
31392775-11 2019 In addition, in the absence of PI3Kgamma activity, there was reduction of cleaved caspase-1 and IL-1beta production in synovial tissue after injection of MSU crystals and leukotriene B4 . Uric Acid 154-157 caspase 1 Mus musculus 82-91
31392775-11 2019 In addition, in the absence of PI3Kgamma activity, there was reduction of cleaved caspase-1 and IL-1beta production in synovial tissue after injection of MSU crystals and leukotriene B4 . Uric Acid 154-157 interleukin 1 alpha Mus musculus 96-104
31392775-12 2019 Our studies suggest that PI3Kgamma is crucial for MSU crystal-induced acute joint inflammation. Uric Acid 50-53 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 25-34
31181404-7 2019 AE did not inhibit xanthine oxidase in vitro; however, 1, 10, and 100 mug/ml of AE significantly decreased uric acid uptake into oocytes expressing hURAT1. Uric Acid 107-116 solute carrier family 22 member 12 Homo sapiens 148-154
30982743-8 2019 The changes in serum uric acid (UA) and beta2-microglobulin (beta2-MG) level were observed after high-RS, low-protein flour intervention (uric acid [mean +- standard deviation]: -24.7 +- 38.5 mumol/L, P = .001; beta2-MG: 0.5 +- 0.9 mg/L, P = 0.018). Uric Acid 138-147 beta-2-microglobulin Homo sapiens 61-69
31315067-0 2019 IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation. Uric Acid 39-55 interleukin 17A Mus musculus 0-6
30824640-0 2019 Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes. Uric Acid 25-34 NLR family pyrin domain containing 3 Homo sapiens 79-84
30824640-1 2019 OBJECTIVE: To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout. Uric Acid 49-58 NLR family pyrin domain containing 3 Homo sapiens 159-164
30824640-1 2019 OBJECTIVE: To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout. Uric Acid 60-62 NLR family pyrin domain containing 3 Homo sapiens 159-164
30824640-2 2019 METHODS: Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and longterm exposure to UA on activation of the NLRP3 inflammasome and subsequent interleukin 1beta (IL-1beta) secretion by ELISA and cell-based assays. Uric Acid 142-144 NLR family pyrin domain containing 3 Homo sapiens 166-171
30824640-2 2019 METHODS: Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and longterm exposure to UA on activation of the NLRP3 inflammasome and subsequent interleukin 1beta (IL-1beta) secretion by ELISA and cell-based assays. Uric Acid 142-144 interleukin 1 beta Homo sapiens 200-217
30824640-4 2019 RESULTS: Precipitation of UA was required for activation of the NLRP3 inflammasome and subsequent release of IL-1beta in human monocytes. Uric Acid 26-28 NLR family pyrin domain containing 3 Homo sapiens 64-69
30824640-4 2019 RESULTS: Precipitation of UA was required for activation of the NLRP3 inflammasome and subsequent release of IL-1beta in human monocytes. Uric Acid 26-28 interleukin 1 beta Homo sapiens 109-117
30824640-9 2019 CONCLUSION: Despite reports indicating that soluble UA can prime and activate the NLRP3 inflammasome in human peripheral blood mononuclear cells, precipitation of soluble UA into MSU crystals is essential for in vitro NLRP3 signaling in primary human monocytes. Uric Acid 52-54 NLR family pyrin domain containing 3 Homo sapiens 82-87
30824640-9 2019 CONCLUSION: Despite reports indicating that soluble UA can prime and activate the NLRP3 inflammasome in human peripheral blood mononuclear cells, precipitation of soluble UA into MSU crystals is essential for in vitro NLRP3 signaling in primary human monocytes. Uric Acid 171-173 NLR family pyrin domain containing 3 Homo sapiens 218-223
31567942-6 2019 The lower sMg group showed a significantly higher prevalence of diabetes mellitus (DM), uric acid levels, and BNP levels compared with the higher sMg group. Uric Acid 88-97 small nuclear ribonucleoprotein polypeptide G Homo sapiens 10-13
31322227-4 2019 The results revealed that peritoneal mesothelial cells stimulated with UA underwent EMT, as demonstrated by the decreased expression of epithelial markers (E-cadherin) and an increased expression of mesenchymal markers (alpha-smooth muscle actin and vimentin). Uric Acid 71-73 cadherin 1 Homo sapiens 156-166
31322227-4 2019 The results revealed that peritoneal mesothelial cells stimulated with UA underwent EMT, as demonstrated by the decreased expression of epithelial markers (E-cadherin) and an increased expression of mesenchymal markers (alpha-smooth muscle actin and vimentin). Uric Acid 71-73 vimentin Homo sapiens 250-258
31322227-5 2019 Additionally, it was reported that UA could facilitate the progression of EMT of peritoneal mesothelial cells via EMT transcription pathways, including transforming growth factor-beta1/mothers against decapentaplegic homolog 3 and P38/mitogen-activated protein kinase by western-blot and reverse transcription semi-quantitative polymerase chain reaction. Uric Acid 35-37 transforming growth factor beta 1 Homo sapiens 152-184
31322227-5 2019 Additionally, it was reported that UA could facilitate the progression of EMT of peritoneal mesothelial cells via EMT transcription pathways, including transforming growth factor-beta1/mothers against decapentaplegic homolog 3 and P38/mitogen-activated protein kinase by western-blot and reverse transcription semi-quantitative polymerase chain reaction. Uric Acid 35-37 SMAD family member 3 Homo sapiens 185-226
31559922-0 2019 APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population. Uric Acid 59-68 apolipoprotein E Homo sapiens 0-4
31559922-1 2019 Aim: To explore the association of APOE polymorphism (rs7412:526C>T and rs429358:388T>C) with glucose, lipid and serum uric acid (UA) metabolism in patients with hypertension or coronary heart disease (CHD). Uric Acid 119-128 apolipoprotein E Homo sapiens 35-39
31559922-1 2019 Aim: To explore the association of APOE polymorphism (rs7412:526C>T and rs429358:388T>C) with glucose, lipid and serum uric acid (UA) metabolism in patients with hypertension or coronary heart disease (CHD). Uric Acid 130-132 apolipoprotein E Homo sapiens 35-39
31559922-7 2019 Conclusion: APOE polymorphism was associated with blood lipid and serum UA metabolism in patients with hypertension or CHD. Uric Acid 72-74 apolipoprotein E Homo sapiens 12-16
31455356-11 2019 CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome. Uric Acid 59-62 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 118-130
31118347-5 2019 Fasting insulin levels, HOMA-IR values, TPOAb levels, serum TSH levels, and serum uric acid levels in the PTC group were higher than those in the control group (p < 0.05). Uric Acid 82-91 coiled-coil domain containing 6 Homo sapiens 106-109
31106362-0 2019 Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. Uric Acid 18-34 sirtuin 1 Mus musculus 0-5
31106362-0 2019 Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. Uric Acid 18-34 thymoma viral proto-oncogene 1 Mus musculus 113-116
31106362-0 2019 Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. Uric Acid 18-34 signal transducer and activator of transcription 6 Mus musculus 117-122
31455356-11 2019 CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome. Uric Acid 59-62 NLR family, pyrin domain containing 3 Mus musculus 224-229
31412804-0 2019 Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 20-25
31415568-3 2019 In humans, elevated UA levels resulted from the loss of the of the urate oxidase (Uro) gene around 15 million years ago. Uric Acid 20-22 Urate oxidase Drosophila melanogaster 82-85
31415568-5 2019 Reduced Uro expression in Drosophila resulted in elevated UA levels, accumulation of concretions in the excretory system, and shortening of lifespan when reared on diets containing high levels of yeast extract. Uric Acid 58-60 Urate oxidase Drosophila melanogaster 8-11
31415568-9 2019 Further support for the role of the ILS pathway in modulating UA metabolism stems from a human candidate gene study identifying SNPs in the ILS genes AKT2 and FOXO3 being associated with serum UA levels or gout. Uric Acid 62-64 AKT serine/threonine kinase 2 Homo sapiens 150-154
31350176-0 2019 The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair. Uric Acid 72-81 SET domain bifurcated histone lysine methyltransferase 2 Homo sapiens 30-36
31350176-6 2019 Setdb2 regulated the expression of xanthine oxidase and thereby the uric acid (UA) pathway of purine catabolism in macrophages, and pharmacologic targeting of Setdb2 or the UA pathway improved healing. Uric Acid 68-77 SET domain bifurcated histone lysine methyltransferase 2 Homo sapiens 0-6
31350176-6 2019 Setdb2 regulated the expression of xanthine oxidase and thereby the uric acid (UA) pathway of purine catabolism in macrophages, and pharmacologic targeting of Setdb2 or the UA pathway improved healing. Uric Acid 79-81 SET domain bifurcated histone lysine methyltransferase 2 Homo sapiens 0-6
31415568-9 2019 Further support for the role of the ILS pathway in modulating UA metabolism stems from a human candidate gene study identifying SNPs in the ILS genes AKT2 and FOXO3 being associated with serum UA levels or gout. Uric Acid 62-64 forkhead box O3 Homo sapiens 159-164
31412804-0 2019 Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux. Uric Acid 0-9 interleukin 1 alpha Homo sapiens 26-34
31415568-9 2019 Further support for the role of the ILS pathway in modulating UA metabolism stems from a human candidate gene study identifying SNPs in the ILS genes AKT2 and FOXO3 being associated with serum UA levels or gout. Uric Acid 193-195 AKT serine/threonine kinase 2 Homo sapiens 150-154
31415568-9 2019 Further support for the role of the ILS pathway in modulating UA metabolism stems from a human candidate gene study identifying SNPs in the ILS genes AKT2 and FOXO3 being associated with serum UA levels or gout. Uric Acid 193-195 forkhead box O3 Homo sapiens 159-164
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 interleukin 1 alpha Homo sapiens 27-35
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 intercellular adhesion molecule 1 Homo sapiens 37-43
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 45-50
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 80-85
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 80-85
31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 caspase 1 Homo sapiens 195-204
31412804-11 2019 In vivo results showed that UA caused the vascular endothelial injury by activating NLRP3/IL-1beta pathway. Uric Acid 28-30 NLR family pyrin domain containing 3 Homo sapiens 84-89
31412804-11 2019 In vivo results showed that UA caused the vascular endothelial injury by activating NLRP3/IL-1beta pathway. Uric Acid 28-30 interleukin 1 alpha Homo sapiens 90-98
31391099-2 2019 Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Uric Acid 62-67 solute carrier family 22 member 12 Homo sapiens 107-112
31489355-1 2019 The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. Uric Acid 116-132 interleukin 17A Mus musculus 77-83
31391099-2 2019 Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Uric Acid 129-134 solute carrier family 22 member 12 Homo sapiens 107-112
31391099-2 2019 Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Uric Acid 129-134 solute carrier family 22 member 12 Homo sapiens 107-112
30903375-7 2019 Adjusted longitudinal analysis showed that FSGS-CKD had a faster decline in LVMI than NG-CKD, and FSGS-CKD had a faster increase in uric acid compared to both groups. Uric Acid 132-141 actinin alpha 4 Homo sapiens 98-106
31222653-6 2019 The results revealed that the two actinomycete extracts S19 and G30 could significantly (p < 0.01) lower the elevated levels of serum creatinine, urea, and uric acid caused by the CCl4 administration. Uric Acid 156-165 C-C motif chemokine ligand 4 Rattus norvegicus 180-184
31165423-8 2019 Uric acid content was associated directly with age and inversely with eGFR, was higher among males, patients with diabetes and high blood pressure. Uric Acid 0-9 epidermal growth factor receptor Homo sapiens 70-74
31209100-0 2019 The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1beta Release. Uric Acid 79-88 gasdermin D Mus musculus 35-46
31209100-3 2019 In this study, we address whether GSDMD and the recently described GSDMD inhibitor necrosulfonamide (NSA) contribute to monosodium urate (MSU) crystal-induced cell death, IL-1beta release, and autoinflammation. Uric Acid 120-136 gasdermin D Mus musculus 34-39
31209100-3 2019 In this study, we address whether GSDMD and the recently described GSDMD inhibitor necrosulfonamide (NSA) contribute to monosodium urate (MSU) crystal-induced cell death, IL-1beta release, and autoinflammation. Uric Acid 120-136 gasdermin D Mus musculus 67-72
31209100-3 2019 In this study, we address whether GSDMD and the recently described GSDMD inhibitor necrosulfonamide (NSA) contribute to monosodium urate (MSU) crystal-induced cell death, IL-1beta release, and autoinflammation. Uric Acid 138-141 gasdermin D Mus musculus 34-39
31209100-4 2019 We demonstrate that MSU crystals, the etiological agent of gout, rapidly activate GSDMD in murine macrophages. Uric Acid 20-23 gasdermin D Mus musculus 82-87
31209100-10 2019 These findings 1) demonstrate that not all IL-1beta-driven autoinflammatory conditions will benefit from the therapeutic targeting of GSDMD, 2) document a unique mechanism of MSU crystal-induced macrophage cell death not rescued by pan-cathepsin inhibition, and 3) show that NSA inhibits inflammasomes upstream of GSDMD to prevent pyroptotic cell death and IL-1beta release. Uric Acid 175-178 gasdermin D Mus musculus 134-139
31209100-10 2019 These findings 1) demonstrate that not all IL-1beta-driven autoinflammatory conditions will benefit from the therapeutic targeting of GSDMD, 2) document a unique mechanism of MSU crystal-induced macrophage cell death not rescued by pan-cathepsin inhibition, and 3) show that NSA inhibits inflammasomes upstream of GSDMD to prevent pyroptotic cell death and IL-1beta release. Uric Acid 175-178 gasdermin D Mus musculus 314-319
31209100-10 2019 These findings 1) demonstrate that not all IL-1beta-driven autoinflammatory conditions will benefit from the therapeutic targeting of GSDMD, 2) document a unique mechanism of MSU crystal-induced macrophage cell death not rescued by pan-cathepsin inhibition, and 3) show that NSA inhibits inflammasomes upstream of GSDMD to prevent pyroptotic cell death and IL-1beta release. Uric Acid 175-178 interleukin 1 alpha Mus musculus 357-365
31257523-0 2019 Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes. Uric Acid 0-5 solute carrier family 22 member 12 Homo sapiens 28-73
31257523-8 2019 Incubation of chondrocytes with sUA led to a concentration-dependent increase in intracellular urate concentrations, which was inhibited by GLUT9 or URAT1 knockdown, or by benzbromarone pretreatment (27.13+-2.70, 44.22+-2.34 and 58.46+-2.32% reduction, respectively). Uric Acid 95-100 solute carrier family 2 member 9 Homo sapiens 140-145
31257523-8 2019 Incubation of chondrocytes with sUA led to a concentration-dependent increase in intracellular urate concentrations, which was inhibited by GLUT9 or URAT1 knockdown, or by benzbromarone pretreatment (27.13+-2.70, 44.22+-2.34 and 58.46+-2.32% reduction, respectively). Uric Acid 95-100 solute carrier family 22 member 12 Homo sapiens 149-154
31324844-5 2019 Production of TNF-alpha, IL-1ss, IL-1RA, MCP-1 and IL-8 was assessed upon addition of 200 microM UA, 500 microM UA or monosodium urate (MSU) crystals in the presence or absence of 5 ng/ml lipopolysaccharide (LPS). Uric Acid 136-139 C-X-C motif chemokine ligand 8 Homo sapiens 51-55
31132013-4 2019 This review discussed the non-glycemic effects of SGLT-2is in patients with T2D and renal impairment, including reductions in systolic and diastolic blood pressure, decreases in albuminuria and plasma uric acid, changes in estimated glomerular filtration rate, and minimal changes in electrolytes. Uric Acid 201-210 solute carrier family 5 member 2 Homo sapiens 50-56
31330801-6 2019 A significant difference in the mean change in eGFR with respect to serum urate target achievement was shown in individuals with chronic kidney disease stage 3 (-0.35 +- 3.87 mL/min/1.73 m2 vs. 5.33 +- 11.64 mL/min/1.73 m2, p = 0.019). Uric Acid 74-79 CD59 molecule (CD59 blood group) Homo sapiens 178-183
31330801-6 2019 A significant difference in the mean change in eGFR with respect to serum urate target achievement was shown in individuals with chronic kidney disease stage 3 (-0.35 +- 3.87 mL/min/1.73 m2 vs. 5.33 +- 11.64 mL/min/1.73 m2, p = 0.019). Uric Acid 74-79 CD59 molecule (CD59 blood group) Homo sapiens 211-216
30903201-10 2019 This study implies a plausible involvement of GR and MR via defective G6PD-dependent antioxidant barrier and increased activity of ADA/XO/UA pathway in postpartum COC-induced hepatic lipid accumulation. Uric Acid 138-140 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 46-48
30807742-3 2019 The cathepsins B, C, L, S and Z have been implicated in NLRP3 inflammasome activation following their activation with ATP, monosodium urate, silica crystals, or bacterial components, among others. Uric Acid 123-139 NLR family pyrin domain containing 3 Homo sapiens 56-61
30807742-8 2019 Cathepsin Z is non-redundantly required for NLRP3 inflammasome activation following nigericin, ATP and monosodium urate activation. Uric Acid 103-119 cathepsin Z Homo sapiens 0-11
30807742-8 2019 Cathepsin Z is non-redundantly required for NLRP3 inflammasome activation following nigericin, ATP and monosodium urate activation. Uric Acid 103-119 NLR family pyrin domain containing 3 Homo sapiens 44-49
31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 NLR family pyrin domain containing 3 Homo sapiens 113-118
31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 interleukin 1 beta Homo sapiens 242-259
31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 interleukin 18 Homo sapiens 264-278
31002842-0 2019 TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid. Uric Acid 90-99 toll-like receptor 2 Rattus norvegicus 0-4
31315601-9 2019 High BMD, old age, male sex, increased weight and height, diabetes, and high osteocalcin and uric acid levels were observed in patients with high serum sclerostin levels and an inverse relation was noticed between PTH and sclerostin. Uric Acid 93-102 sclerostin Homo sapiens 152-162
31129265-6 2019 Exenatide analogues, urate, nilotinib and lithium have been shown to affect one or more of the above kinases, actions that can decrease the formation and increase the clearance of intraneuronal phosphorylated tau and alpha-synuclein. Uric Acid 21-26 microtubule associated protein tau Homo sapiens 209-212
31129265-6 2019 Exenatide analogues, urate, nilotinib and lithium have been shown to affect one or more of the above kinases, actions that can decrease the formation and increase the clearance of intraneuronal phosphorylated tau and alpha-synuclein. Uric Acid 21-26 synuclein alpha Homo sapiens 217-232
31214670-3 2019 Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Uric Acid 46-49 interleukin 1 beta Homo sapiens 86-103
31214670-3 2019 Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Uric Acid 46-49 interleukin 1 beta Homo sapiens 105-113
31214670-3 2019 Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Uric Acid 46-49 tumor necrosis factor Homo sapiens 119-146
31214670-3 2019 Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Uric Acid 46-49 tumor necrosis factor Homo sapiens 148-157
31017011-2 2019 Urine pH is also of particular interest in stone formers, since it determines the presence of either calcium phosphate or uric acid content in stones. Uric Acid 122-131 phenylalanine hydroxylase Homo sapiens 6-8
31017011-3 2019 Others have noted in epidemiological studies a rise in incidence of low pH-dependent uric acid stones with age, coinciding with a decrease in the incidence of high pH-dependent phosphate stones. Uric Acid 85-94 phenylalanine hydroxylase Homo sapiens 72-74
31002842-0 2019 TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid. Uric Acid 90-99 toll-like receptor 4 Rattus norvegicus 9-13
31002842-8 2019 In vitro study, uric acid caused a dose- and time-dependent increase in the mRNA expression of TLR2 and TLR4 in rat adipocytes. Uric Acid 16-25 toll-like receptor 2 Rattus norvegicus 95-99
31002842-8 2019 In vitro study, uric acid caused a dose- and time-dependent increase in the mRNA expression of TLR2 and TLR4 in rat adipocytes. Uric Acid 16-25 toll-like receptor 4 Rattus norvegicus 104-108
31002842-11 2019 In conclusion, TLR2/4 mediated adipose inflammation plays a key role in RAS activation induced by uric acid in adipose tissue. Uric Acid 98-107 toll-like receptor 2 Rattus norvegicus 15-21
30536556-4 2019 With the aim to evaluate the effect of uric acid (UA) and Ang II on oxidative stress and inflammation mediated by toll-like receptor 4 (TLR4) activation in human PTECs, human kidney 2 (HK2) were incubated for 24 hr with UA (12 mg/dl) and Ang II (10 -7 M). Uric Acid 50-52 toll like receptor 4 Homo sapiens 114-134
30734168-0 2019 Association of serum uric acid levels with the incident of kidney disease and rapid eGFR decline in Chinese individuals with eGFR > 60 mL/min/1.73 m2 and negative proteinuria. Uric Acid 21-30 CD59 molecule (CD59 blood group) Homo sapiens 141-146
30536556-4 2019 With the aim to evaluate the effect of uric acid (UA) and Ang II on oxidative stress and inflammation mediated by toll-like receptor 4 (TLR4) activation in human PTECs, human kidney 2 (HK2) were incubated for 24 hr with UA (12 mg/dl) and Ang II (10 -7 M). Uric Acid 50-52 toll like receptor 4 Homo sapiens 136-140
30536556-0 2019 Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4. Uric Acid 0-9 toll like receptor 4 Homo sapiens 130-150
31487640-2 2019 ATP-binding cassette subfamily G member 2 (ABCG2) has a very strong effect on the serum urate concentrations. Uric Acid 88-93 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-41
30536556-4 2019 With the aim to evaluate the effect of uric acid (UA) and Ang II on oxidative stress and inflammation mediated by toll-like receptor 4 (TLR4) activation in human PTECs, human kidney 2 (HK2) were incubated for 24 hr with UA (12 mg/dl) and Ang II (10 -7 M). Uric Acid 39-48 toll like receptor 4 Homo sapiens 114-134
30536556-4 2019 With the aim to evaluate the effect of uric acid (UA) and Ang II on oxidative stress and inflammation mediated by toll-like receptor 4 (TLR4) activation in human PTECs, human kidney 2 (HK2) were incubated for 24 hr with UA (12 mg/dl) and Ang II (10 -7 M). Uric Acid 39-48 toll like receptor 4 Homo sapiens 136-140
30516339-1 2019 AIMS/INTRODUCTION: Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Uric Acid 90-99 xanthine dehydrogenase Homo sapiens 19-42
31118497-1 2019 Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates, including in humans, because of inactivation of the gene encoding uricase during primate evolution. Uric Acid 32-37 urate oxidase (pseudogene) Homo sapiens 153-160
30516339-1 2019 AIMS/INTRODUCTION: Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Uric Acid 90-99 xanthine dehydrogenase Homo sapiens 44-47
31487640-2 2019 ATP-binding cassette subfamily G member 2 (ABCG2) has a very strong effect on the serum urate concentrations. Uric Acid 88-93 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 43-48
30516339-6 2019 Plasma XOR activity was positively correlated with concentrations of FABP4 (r = 0.192, P < 0.001) and FGF21 (r = 0.208, P < 0.001), homeostasis model assessment of insulin resistance as an index of insulin resistance and uric acid, and was negatively correlated with adiponectin level (r = -0.243, P = 0.001). Uric Acid 227-236 xanthine dehydrogenase Homo sapiens 7-10
30954486-0 2019 Uric acid treatment after stroke modulates the Kruppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. Uric Acid 0-9 Kruppel-like factor 2 Rattus norvegicus 47-68
30516339-7 2019 Multivariate regression analyses showed that levels of adiponectin, FABP4 and FGF21 were independent determinants of plasma XOR activity after adjusting age, sex, uric acid and homeostasis model assessment of insulin resistance. Uric Acid 163-172 adiponectin, C1Q and collagen domain containing Homo sapiens 55-66
30516339-7 2019 Multivariate regression analyses showed that levels of adiponectin, FABP4 and FGF21 were independent determinants of plasma XOR activity after adjusting age, sex, uric acid and homeostasis model assessment of insulin resistance. Uric Acid 163-172 xanthine dehydrogenase Homo sapiens 124-127
30954486-0 2019 Uric acid treatment after stroke modulates the Kruppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension. Uric Acid 0-9 vascular endothelial growth factor A Rattus norvegicus 69-73
30954486-2 2019 High concentrations of UA inhibit angiogenesis of cultured endothelial cells via Kruppel-like factor 2 (KLF)-induced downregulation of vascular endothelial growth factor (VEGF), a pro-angiogenic mediator that is able to increase blood-brain barrier (BBB) permeability in acute stroke. Uric Acid 23-25 Kruppel-like factor 2 Rattus norvegicus 81-102
30954486-2 2019 High concentrations of UA inhibit angiogenesis of cultured endothelial cells via Kruppel-like factor 2 (KLF)-induced downregulation of vascular endothelial growth factor (VEGF), a pro-angiogenic mediator that is able to increase blood-brain barrier (BBB) permeability in acute stroke. Uric Acid 23-25 Kruppel-like factor 2 Rattus norvegicus 104-107
30954486-2 2019 High concentrations of UA inhibit angiogenesis of cultured endothelial cells via Kruppel-like factor 2 (KLF)-induced downregulation of vascular endothelial growth factor (VEGF), a pro-angiogenic mediator that is able to increase blood-brain barrier (BBB) permeability in acute stroke. Uric Acid 23-25 vascular endothelial growth factor A Rattus norvegicus 135-169
30954486-2 2019 High concentrations of UA inhibit angiogenesis of cultured endothelial cells via Kruppel-like factor 2 (KLF)-induced downregulation of vascular endothelial growth factor (VEGF), a pro-angiogenic mediator that is able to increase blood-brain barrier (BBB) permeability in acute stroke. Uric Acid 23-25 vascular endothelial growth factor A Rattus norvegicus 171-175
30954486-3 2019 Here, we investigated whether UA treatment after ischaemic stroke protects brain endothelial cell functions and modulates the KLF2-VEGF-A axis. Uric Acid 30-32 Kruppel-like factor 2 Rattus norvegicus 126-130
30954486-3 2019 Here, we investigated whether UA treatment after ischaemic stroke protects brain endothelial cell functions and modulates the KLF2-VEGF-A axis. Uric Acid 30-32 vascular endothelial growth factor A Rattus norvegicus 131-137
30954486-11 2019 UA treatment reduced infarct volume and Evans blue leakage in both rat strains, improved endothelial cell barrier integrity and KLF2 expression, and lowered VEGF-A levels in SHR rats. Uric Acid 0-2 Kruppel-like factor 2 Rattus norvegicus 128-132
30954486-11 2019 UA treatment reduced infarct volume and Evans blue leakage in both rat strains, improved endothelial cell barrier integrity and KLF2 expression, and lowered VEGF-A levels in SHR rats. Uric Acid 0-2 vascular endothelial growth factor A Rattus norvegicus 157-163
30954486-12 2019 Hypertensive stroke patients treated with UA showed lower levels of VEGF-A than patients receiving vehicle. Uric Acid 42-44 vascular endothelial growth factor A Homo sapiens 68-74
30954486-13 2019 Consistently, UA prevented the enhanced MCA angiogenesis in SHR rats by a mechanism involving KLF2 activation. Uric Acid 14-16 Kruppel-like factor 2 Rattus norvegicus 94-98
30954486-14 2019 We conclude that UA treatment after ischaemic stroke upregulates KLF2, reduces VEGF-A signalling, and attenuates brain endothelial cell dysfunctions leading to neuroprotection. Uric Acid 17-19 Kruppel-like factor 2 Rattus norvegicus 65-69
30954486-14 2019 We conclude that UA treatment after ischaemic stroke upregulates KLF2, reduces VEGF-A signalling, and attenuates brain endothelial cell dysfunctions leading to neuroprotection. Uric Acid 17-19 vascular endothelial growth factor A Rattus norvegicus 79-85
30708071-2 2019 Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. Uric Acid 159-168 solute carrier family 5 member 2 Homo sapiens 0-35
30708071-2 2019 Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. Uric Acid 159-168 solute carrier family 5 member 2 Homo sapiens 37-42
30936145-1 2019 Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Uric Acid 152-161 xanthine dehydrogenase Mus musculus 93-116
30762288-3 2019 This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio-renal risk. Uric Acid 75-84 solute carrier family 5 member 2 Homo sapiens 49-54
30762288-7 2019 Treating type 2 diabetes with an SGLT2 inhibitor increases uric acid excretion, reduces circulating uric acid and improves parameters of CV and renal function. Uric Acid 59-68 solute carrier family 5 member 2 Homo sapiens 33-38
30762288-7 2019 Treating type 2 diabetes with an SGLT2 inhibitor increases uric acid excretion, reduces circulating uric acid and improves parameters of CV and renal function. Uric Acid 100-109 solute carrier family 5 member 2 Homo sapiens 33-38
30762288-8 2019 This raises the possibility that the lowering of uric acid by SGLT2 inhibition may assist in reducing adverse CV events and slowing progression of CKD in type 2 diabetes. Uric Acid 49-58 solute carrier family 5 member 2 Homo sapiens 62-67
30936145-1 2019 Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Uric Acid 152-161 xanthine dehydrogenase Mus musculus 118-121
30936145-1 2019 Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Uric Acid 26-28 xanthine dehydrogenase Mus musculus 93-116
30936145-1 2019 Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Uric Acid 26-28 xanthine dehydrogenase Mus musculus 118-121
30936145-3 2019 Deletion of hepatocyte Xdh substantially lowered liver and plasma UA concentration. Uric Acid 66-68 xanthine dehydrogenase Mus musculus 23-26
30936145-7 2019 These data demonstrate that hepatocyte XOR activity is a critical determinant of systemic UA homeostasis, that deletion of hepatocyte Xdh is sufficient to prevent systemic HyUA of obesity, and that neither prevention nor correction of HyUA improves insulin resistance/dyslipidemia in obesity. Uric Acid 90-92 xanthine dehydrogenase Mus musculus 39-42
30448992-5 2019 RESULTS: Circulating SELENOP levels were associated with 24 out of 572 metabolites after accounting for the number of independent dimensions in the metabolomics data, including inverse associations with alanine, glutamate, leucine, isoleucine and valine, an unknown compound X-12063, urate and the peptides gamma-glutamyl-leucine, and N-acetylcarnosine. Uric Acid 284-289 selenoprotein P Homo sapiens 21-28
29385859-1 2019 OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1beta levels. Uric Acid 157-173 leucine rich repeat containing 3 Homo sapiens 79-119
30592338-2 2019 The performance of the fabricated biosensor was evaluated, and the results indicated that the biosensor exhibited high sensitivity in UA detection, with a linear range from 0.04 to 45 muM and a limit of detection of 0.01 muM. Uric Acid 134-136 latexin Homo sapiens 184-187
30592338-2 2019 The performance of the fabricated biosensor was evaluated, and the results indicated that the biosensor exhibited high sensitivity in UA detection, with a linear range from 0.04 to 45 muM and a limit of detection of 0.01 muM. Uric Acid 134-136 latexin Homo sapiens 221-224
30806957-3 2019 In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1beta production by TDB-stimulated macrophages. Uric Acid 30-46 interleukin 1 beta Mus musculus 90-98
30806957-3 2019 In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1beta production by TDB-stimulated macrophages. Uric Acid 48-51 interleukin 1 beta Mus musculus 90-98
29385859-1 2019 OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1beta levels. Uric Acid 157-173 NLR family pyrin domain containing 3 Homo sapiens 121-126
29385859-1 2019 OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1beta levels. Uric Acid 157-173 interleukin 1 beta Homo sapiens 255-263
31189953-1 2019 The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-beta fibrils and extracellular ATP. Uric Acid 75-84 NLR family pyrin domain containing 3 Homo sapiens 4-9
30880174-3 2019 When a gender-stratified analysis was ran, the miR-146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. Uric Acid 144-153 microRNA 146a Homo sapiens 47-55
30880174-4 2019 In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. Uric Acid 82-91 microRNA 146a Homo sapiens 10-18
31146764-0 2019 Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion. Uric Acid 58-67 ATP binding cassette subfamily C member 4 Homo sapiens 32-36
31146764-1 2019 BACKGROUND: Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Uric Acid 110-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 12-44
31146764-0 2019 Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion. Uric Acid 58-67 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 23-27
31146764-1 2019 BACKGROUND: Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Uric Acid 110-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 46-50
31146764-1 2019 BACKGROUND: Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Uric Acid 110-119 ATP binding cassette subfamily C member 4 Homo sapiens 56-86
31146764-1 2019 BACKGROUND: Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Uric Acid 110-119 ATP binding cassette subfamily C member 4 Homo sapiens 88-92
31281508-7 2019 Results: We found that secreted frizzled-related protein 2 (sFRP2) was the most upregulated gene in dorsal root ganglion (DRG) neurons in response to monosodium urate (MSU) deposition. Uric Acid 150-166 secreted frizzled-related protein 2 Mus musculus 23-58
31146764-12 2019 CONCLUSION: Together, these results demonstrate that BCRP and MRP4 are involved in renal and intestinal uric acid excretion in chickens and that BCRP is positively related to MRP4 expression. Uric Acid 104-113 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 53-57
31281508-7 2019 Results: We found that secreted frizzled-related protein 2 (sFRP2) was the most upregulated gene in dorsal root ganglion (DRG) neurons in response to monosodium urate (MSU) deposition. Uric Acid 150-166 secreted frizzled-related protein 2 Mus musculus 60-65
31281508-7 2019 Results: We found that secreted frizzled-related protein 2 (sFRP2) was the most upregulated gene in dorsal root ganglion (DRG) neurons in response to monosodium urate (MSU) deposition. Uric Acid 168-171 secreted frizzled-related protein 2 Mus musculus 23-58
31281508-7 2019 Results: We found that secreted frizzled-related protein 2 (sFRP2) was the most upregulated gene in dorsal root ganglion (DRG) neurons in response to monosodium urate (MSU) deposition. Uric Acid 168-171 secreted frizzled-related protein 2 Mus musculus 60-65
31146764-12 2019 CONCLUSION: Together, these results demonstrate that BCRP and MRP4 are involved in renal and intestinal uric acid excretion in chickens and that BCRP is positively related to MRP4 expression. Uric Acid 104-113 ATP binding cassette subfamily C member 4 Homo sapiens 62-66
31146764-12 2019 CONCLUSION: Together, these results demonstrate that BCRP and MRP4 are involved in renal and intestinal uric acid excretion in chickens and that BCRP is positively related to MRP4 expression. Uric Acid 104-113 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 145-149
31146764-12 2019 CONCLUSION: Together, these results demonstrate that BCRP and MRP4 are involved in renal and intestinal uric acid excretion in chickens and that BCRP is positively related to MRP4 expression. Uric Acid 104-113 ATP binding cassette subfamily C member 4 Homo sapiens 175-179
31146764-13 2019 Further, impairment of renal function results in an increase in serum uric acid as well as a compensatory increase in BCRP and MRP4 in the ileum; however, under normal renal function, renal BCRP and MRP4 are the main regulators of uric acid excretion. Uric Acid 231-240 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 190-194
31146764-13 2019 Further, impairment of renal function results in an increase in serum uric acid as well as a compensatory increase in BCRP and MRP4 in the ileum; however, under normal renal function, renal BCRP and MRP4 are the main regulators of uric acid excretion. Uric Acid 231-240 ATP binding cassette subfamily C member 4 Homo sapiens 199-203
31193394-9 2019 Uric acid level determination revealed that the ethanolic extract of M. charantia reduced serum uric acid level both in experimental groups (Gr-2 and Gr-3). Uric Acid 96-105 prolactin releasing hormone receptor Mus musculus 150-154
31141540-9 2019 These research findings bring further support to the growing evidence that the mechanism of the liver injury induced by the compounds from urate-lowering Chinese herbs may be associated with the activation of p38alpha. Uric Acid 139-144 mitogen-activated protein kinase 14 Homo sapiens 209-217
31118410-5 2019 We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA alpha1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1beta (IL-1beta) in PTECs. Uric Acid 194-196 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 51-55
31118410-9 2019 Sustained AMPK activation could reduce lysosomal NKA degradation and maintain NKA function, thus alleviating NKA downstream inflammation and protecting tubular cells from high UA-induced renal tubular injury. Uric Acid 176-178 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 10-14
31108534-0 2019 Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels. Uric Acid 72-81 interleukin 1 beta Homo sapiens 16-33
31231373-0 2019 Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation. Uric Acid 73-89 delta/notch-like EGF repeat containing Mus musculus 41-44
31231373-11 2019 In addition, plasma IL-17 and IL-23 levels were elevated in acute gout, whereas protein levels of T-bet were downregulated in PBMCs from acute gout patients and intercritical gout treated with MSU crystals in vitro as well. Uric Acid 193-196 interleukin 17A Homo sapiens 20-25
31231373-11 2019 In addition, plasma IL-17 and IL-23 levels were elevated in acute gout, whereas protein levels of T-bet were downregulated in PBMCs from acute gout patients and intercritical gout treated with MSU crystals in vitro as well. Uric Acid 193-196 interleukin 23 subunit alpha Homo sapiens 30-35
31231373-11 2019 In addition, plasma IL-17 and IL-23 levels were elevated in acute gout, whereas protein levels of T-bet were downregulated in PBMCs from acute gout patients and intercritical gout treated with MSU crystals in vitro as well. Uric Acid 193-196 delta/notch like EGF repeat containing Homo sapiens 100-103
31118410-0 2019 AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules. Uric Acid 21-30 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-4
31118410-0 2019 AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules. Uric Acid 21-30 tachykinin precursor 1 Homo sapiens 39-52
31118410-4 2019 We first detected AMPK activation in high uric acid (UA)-stimulated proximal tubular epithelial cells (PTECs). Uric Acid 42-51 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 18-22
31118410-4 2019 We first detected AMPK activation in high uric acid (UA)-stimulated proximal tubular epithelial cells (PTECs). Uric Acid 53-55 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 18-22
31013064-3 2019 The MOF material showed a fast, selective, sensitive (detection limit 1.4 muM), and ratiometric fluorescence response toward UA in pure aqueous medium. Uric Acid 125-127 latexin Homo sapiens 74-77
31067818-9 2019 Interestingly, amongst the RPL patients, higher levels of homocysteine (P = 0.042) and uric acid (P = 0.046) were associated with MMP-27 rs3809017 T>C. Uric Acid 87-96 matrix metallopeptidase 27 Homo sapiens 130-136
30782366-4 2019 The electrochemical investigation showed that the sensor performed good selectivity and wide linear ranges for the simultaneous detection of dopamine (0.5-150 muM) and uric acid (0.5-600 muM). Uric Acid 168-177 latexin Homo sapiens 187-190
29523220-10 2019 Probenecid inhibits SLC2A9-mediated uric acid transport, which promotes cell proliferation, inhibits cell apoptosis, induces intracellular ROS, and decreases the expression of p53 in HCC cells. Uric Acid 36-45 solute carrier family 2 member 9 Homo sapiens 20-26
31186646-4 2019 Under optimized method and solution parameters, linear dependence of peak current on uric acid concentration in a wide range of 1-120 muM, low detection limit value (0.06 muM), replicate results with low RSD, and excellent recovery results (96.61-103.45%) validated the developed adsorptive anodic stripping square wave voltammetric (AdsASSWV) method for determination of uric acid even in aqueous human urine samples. Uric Acid 85-94 latexin Homo sapiens 134-137
31198782-10 2019 Conclusion: The major potential biomarkers in maternal urine associated with CHD were 4-hydroxybenzeneacetic acid, 5-trimethylsilyloxy-n-valeric acid, propanedioic acid, hydracrylic acid, and uric acid, respectively. Uric Acid 192-201 choline dehydrogenase Homo sapiens 77-80
29563107-0 2019 Response to: "The reference levels of serum urate for clinically evident incident gout" by Chen and Ding. Uric Acid 44-49 ring finger protein 2 Homo sapiens 100-104
30785349-1 2019 The objective of the present study was to theoretically investigate the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors, including Na+, parathyroid hormone, ANG II, and Na+-glucose cotransporter-2 inhibitors. Uric Acid 94-103 angiotensinogen Rattus norvegicus 227-233
30785349-1 2019 The objective of the present study was to theoretically investigate the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors, including Na+, parathyroid hormone, ANG II, and Na+-glucose cotransporter-2 inhibitors. Uric Acid 94-103 solute carrier family 5 member 2 Rattus norvegicus 239-266
30926645-0 2019 Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout. Uric Acid 16-32 leptin Homo sapiens 0-6
30814053-0 2019 mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy? Uric Acid 37-53 mechanistic target of rapamycin kinase Homo sapiens 0-4
30814053-3 2019 Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. Uric Acid 28-31 mechanistic target of rapamycin kinase Homo sapiens 52-83
30814053-3 2019 Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. Uric Acid 28-31 mechanistic target of rapamycin kinase Homo sapiens 85-89
30814053-7 2019 RESULTS: We show that ex vivo immune cells from patients with gout exhibit higher expression of the mTOR pathway, which we can mimic in vitro by stimulating healthy immune cells (B lymphocytes, monocytes, T lymphocytes) with MSU crystals. Uric Acid 225-228 mechanistic target of rapamycin kinase Homo sapiens 100-104
30408836-6 2019 5-Hydroxyisourate (HIU), the oxidation product of UA, was however only formed by KNO2 , PCC, and H2 O2 . Uric Acid 50-52 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 81-85
30885031-1 2019 Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity. Uric Acid 217-226 purine nucleoside phosphorylase Homo sapiens 0-31
30885031-1 2019 Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity. Uric Acid 217-226 purine nucleoside phosphorylase Homo sapiens 33-36
30890227-4 2019 Uricase is an efficient oxidase, which can oxidize uric acid to allantoin and hydrogen peroxide, to reduce the uric acid level. Uric Acid 51-60 urate oxidase (pseudogene) Homo sapiens 0-7
30890227-4 2019 Uricase is an efficient oxidase, which can oxidize uric acid to allantoin and hydrogen peroxide, to reduce the uric acid level. Uric Acid 111-120 urate oxidase (pseudogene) Homo sapiens 0-7
30890227-8 2019 An in vivo study demonstrated that the uricase&HRP-CaHPO4 @HA MN could effectively reduce the uric acid level of blood as intravenous injection without side effects. Uric Acid 98-107 urate oxidase (pseudogene) Homo sapiens 39-46
30926645-5 2019 Leptin facilitates the stimulation of human synoviocytes, mouse peritoneal macrophages, and HL-60 cells induced by monosodium urate, leading to higher levels of acute gout-related proinflammatory factors. Uric Acid 115-131 leptin Homo sapiens 0-6
30926645-6 2019 Leptin obviously exacerbates the inflammation of monosodium urate-induced acute gouty arthritis in wild-type mice, whereas that in leptin-deficient C57BL6/Job/ob mice is markedly alleviated. Uric Acid 49-65 leptin Mus musculus 0-6
30833078-8 2019 CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-kappaB signaling pathway and intracellular TXNIP shifting. Uric Acid 49-52 thioredoxin interacting protein Homo sapiens 89-94
31105747-0 2019 Corrigendum: Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Uric Acid 24-29 long intergenic non-protein coding RNA 1229 Homo sapiens 91-100
31105747-0 2019 Corrigendum: Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Uric Acid 24-29 MAF transcriptional regulator RNA Homo sapiens 105-111
30994184-1 2021 BACKGROUND: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). Uric Acid 204-213 matrix metallopeptidase 3 Homo sapiens 153-157
30994184-2 2021 The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity. Uric Acid 69-71 matrix metallopeptidase 3 Homo sapiens 102-106
30994184-7 2021 Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Uric Acid 90-92 matrix metallopeptidase 3 Homo sapiens 42-47
30994184-8 2021 Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Uric Acid 81-83 matrix metallopeptidase 3 Homo sapiens 102-107
30994184-10 2021 CONCLUSIONS: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT. Uric Acid 85-87 matrix metallopeptidase 3 Homo sapiens 100-104
30833078-0 2019 TXNIP-mediated nuclear factor-kappaB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome. Uric Acid 94-103 thioredoxin interacting protein Homo sapiens 0-5
30833078-0 2019 TXNIP-mediated nuclear factor-kappaB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome. Uric Acid 94-103 nuclear factor kappa B subunit 1 Homo sapiens 15-36
30833078-0 2019 TXNIP-mediated nuclear factor-kappaB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome. Uric Acid 94-103 thioredoxin interacting protein Homo sapiens 85-90
30833078-0 2019 TXNIP-mediated nuclear factor-kappaB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome. Uric Acid 94-103 NLR family pyrin domain containing 3 Homo sapiens 112-117
30833078-8 2019 CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-kappaB signaling pathway and intracellular TXNIP shifting. Uric Acid 49-52 nuclear factor kappa B subunit 1 Homo sapiens 104-113
30833078-8 2019 CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-kappaB signaling pathway and intracellular TXNIP shifting. Uric Acid 49-52 thioredoxin interacting protein Homo sapiens 150-155
31065383-8 2019 Urinary uromodulin levels were significantly lower in CKD cases compared to both controls and first-degree relatives and correlated negatively with age, serum uric acid, serum creatinine, and systolic BP and positively with CKD-EPI eGFR. Uric Acid 159-168 uromodulin Homo sapiens 8-18
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 263-279 thioredoxin interacting protein Homo sapiens 92-97
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 263-279 thioredoxin interacting protein Homo sapiens 174-179
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 263-279 NLR family pyrin domain containing 3 Homo sapiens 184-211
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 281-284 thioredoxin interacting protein Homo sapiens 92-97
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 281-284 thioredoxin interacting protein Homo sapiens 174-179
30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 281-284 NLR family pyrin domain containing 3 Homo sapiens 184-211
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 interleukin 1 alpha Homo sapiens 83-91
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 interleukin 18 Homo sapiens 93-98
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 caspase 1 Homo sapiens 100-109
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 thioredoxin interacting protein Homo sapiens 115-120
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 nuclear factor kappa B subunit 1 Homo sapiens 139-148
30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 thioredoxin interacting protein Homo sapiens 239-244
30833078-5 2019 Intracellular translocation of TXNIP from the nucleus to mitochondria was observed in cells treated with MSU crystals. Uric Acid 105-108 thioredoxin interacting protein Homo sapiens 31-36
30833078-7 2019 Binding between TXNIP and NLRP3 under oxidative stress caused by MSU crystals was observed and was blocked by quercetin or ascorbic acid. Uric Acid 65-68 thioredoxin interacting protein Homo sapiens 16-21
30833078-7 2019 Binding between TXNIP and NLRP3 under oxidative stress caused by MSU crystals was observed and was blocked by quercetin or ascorbic acid. Uric Acid 65-68 NLR family pyrin domain containing 3 Homo sapiens 26-31
30833078-8 2019 CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-kappaB signaling pathway and intracellular TXNIP shifting. Uric Acid 49-52 NLR family pyrin domain containing 3 Homo sapiens 61-66
31031707-6 2019 Results: The obesity-related SNP in MSRA rs545854 significantly affected serum uric acid levels. Uric Acid 79-88 methionine sulfoxide reductase A Homo sapiens 36-40
31110596-3 2019 Therefore, this study investigated the association among high serum uric acid concentrations, renal tubular damage, and renal inflammation assessed via estimation of urinary kidney injury molecule-1 (KIM-1) and inflammatory cytokines in patients with type 2 diabetes (T2D). Uric Acid 68-77 hepatitis A virus cellular receptor 1 Homo sapiens 200-205
31110596-6 2019 Results: Urinary KIM-1, IL-1, IL-6, and TNF-alpha were higher in patients with serum uric acid concentrations >= 6.0 mg/dL. Uric Acid 85-94 hepatitis A virus cellular receptor 1 Homo sapiens 17-22
31110596-6 2019 Results: Urinary KIM-1, IL-1, IL-6, and TNF-alpha were higher in patients with serum uric acid concentrations >= 6.0 mg/dL. Uric Acid 85-94 interleukin 6 Homo sapiens 30-34
31110596-6 2019 Results: Urinary KIM-1, IL-1, IL-6, and TNF-alpha were higher in patients with serum uric acid concentrations >= 6.0 mg/dL. Uric Acid 85-94 tumor necrosis factor Homo sapiens 40-49
31110596-8 2019 Serum uric acid concentrations were significantly associated with urinary KIM-1 (values normalized by urinary creatinine concentration) and urinary TNF-alpha (absolute values and values normalized by urinary creatinine concentration), independent of the body mass index (BMI) and estimated glomerular filtration rate (eGFR). Uric Acid 6-15 hepatitis A virus cellular receptor 1 Homo sapiens 74-79
31110596-8 2019 Serum uric acid concentrations were significantly associated with urinary KIM-1 (values normalized by urinary creatinine concentration) and urinary TNF-alpha (absolute values and values normalized by urinary creatinine concentration), independent of the body mass index (BMI) and estimated glomerular filtration rate (eGFR). Uric Acid 6-15 tumor necrosis factor Homo sapiens 148-157
31110596-9 2019 Conclusions: High serum uric acid concentrations were associated with high urinary KIM-1 levels accompanied by the increase of urinary proinflammatory cytokines in patients with T2D. Uric Acid 24-33 hepatitis A virus cellular receptor 1 Homo sapiens 83-88
30940115-0 2019 Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. Uric Acid 13-22 cystatin C Homo sapiens 85-95
30618054-0 2019 Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers. Uric Acid 59-68 myeloperoxidase Homo sapiens 76-91
30648910-0 2019 Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy. Uric Acid 39-48 mitogen activated protein kinase 3 Rattus norvegicus 12-18
30761591-0 2019 Higher urate in LRRK2 mutation carriers resistant to Parkinson disease. Uric Acid 7-12 leucine rich repeat kinase 2 Homo sapiens 16-21
30761591-2 2019 The present study investigates whether urate, an antioxidant, Nrf2 activator, and inverse risk factor for idiopathic PD, is one such candidate biomarker of PD risk modulation in pathogenic LRRK2 mutation carriers. Uric Acid 39-44 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66
30761591-2 2019 The present study investigates whether urate, an antioxidant, Nrf2 activator, and inverse risk factor for idiopathic PD, is one such candidate biomarker of PD risk modulation in pathogenic LRRK2 mutation carriers. Uric Acid 39-44 leucine rich repeat kinase 2 Homo sapiens 189-194
30761591-5 2019 RESULTS: Nonmanifesting LRRK2 mutation carriers had significantly higher levels of urate than those who developed PD in each of the 3 independent cohorts. Uric Acid 83-88 leucine rich repeat kinase 2 Homo sapiens 24-29
30761591-8 2019 INTERPRETATION: These findings identify and substantiate urate as a biomarker of resistance to PD among LRRK2 mutation carriers. Uric Acid 57-62 leucine rich repeat kinase 2 Homo sapiens 104-109
30373883-0 2019 Urate-lowering therapy (ULT) reduces non-episodic foot pain in patients who fail to meet ACR/EULAR 2015 gout classification criteria: an effect predicted by ultrasound and potential rationale for reclassification. Uric Acid 0-5 acrosin Homo sapiens 89-92
31016517-1 2019 EN: Summary]This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population, the Uygurs in Xinjiang, China. Uric Acid 106-115 solute carrier family 2 member 9 Homo sapiens 96-102
31016517-8 2019 There were significant or marginal correlations between certain single nucleotide polymorphisms in the SLC2A9 region and uric acid concentration in Uygur normouricemia samples. Uric Acid 121-130 solute carrier family 2 member 9 Homo sapiens 103-109
30847808-3 2019 Adjusted and unadjusted geometric means of uric acid increased from GF-1 to GF-3B/4 for males and females. Uric Acid 43-52 GATA binding protein 1 Homo sapiens 68-83
30620450-6 2019 The multivariate logistic regression model showed that serum uric acid (per 1.0 mg/dL increase, odds ratio: 1.280; 95% confidence interval: 1.066-1.536; P = 0.008) and lactate levels (per 1.0 mmol/L increase, odds ratio: 1.239; 95% confidence interval: 1.040-1.475; P = 0.016) were independently associated with high plasma XOR activity (>300 pg/h/mL) during the acute phase of AHF. Uric Acid 61-70 xanthine dehydrogenase Homo sapiens 324-327
30847808-4 2019 Adjusted geometric means for uric acid were higher for males by 1.38, 1.03, and 0.62 mg/dL for GF-1, GF2, and GF-3 respectively but for GF-3B/4, females had higher adjusted geometric means than males by 0.16 mg/dL, revealing narrowing of sex differences in uric acid as glomerular function declines. Uric Acid 29-38 GATA binding protein 1 Homo sapiens 95-114
30847808-5 2019 The direction of association between PFAS and uric acid was positive for GF-1 and GF-2 for males and for every PFAS except PFDA for females. Uric Acid 46-55 GATA binding protein 1 Homo sapiens 73-86
30690853-9 2019 Urate-lowering treatment alleviated atherosclerosis inflammatory response factors and reactive oxygen species (ROS) intensities in both collar placement Uox-KO mice and urate-stimulated human umbilical vein endothelial cells (HUVECs). Uric Acid 0-5 urate oxidase Mus musculus 153-156
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 solute carrier family 2 member 9 Homo sapiens 144-149
31084401-7 2019 Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. Uric Acid 37-40 neutrophil cytosolic factor 1 Mus musculus 49-78
31084401-7 2019 Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. Uric Acid 37-40 caspase 1 Mus musculus 80-89
31084401-7 2019 Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. Uric Acid 37-40 NLR family, pyrin domain containing 3 Mus musculus 94-99
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 potassium two pore domain channel subfamily K member 3 Homo sapiens 119-123
30592318-0 2019 Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling. Uric Acid 21-37 NLR family, pyrin domain containing 3 Rattus norvegicus 70-89
30592318-8 2019 RESULTS: Curcumin could reduce MSU crystals-induced IL-1beta and TNF-alpha in vitro. Uric Acid 31-34 interleukin 1 alpha Rattus norvegicus 52-60
30592318-8 2019 RESULTS: Curcumin could reduce MSU crystals-induced IL-1beta and TNF-alpha in vitro. Uric Acid 31-34 tumor necrosis factor Rattus norvegicus 65-74
30592318-11 2019 Intraperitoneal administration of curcumin could ameliorate symptoms of MSU-induced gouty arthritis, including the joint circumference, infiltration of neutrophils in knee joints, and production of IL-1beta, TNF-alpha, and elastase. Uric Acid 72-75 interleukin 1 alpha Rattus norvegicus 198-206
30592318-11 2019 Intraperitoneal administration of curcumin could ameliorate symptoms of MSU-induced gouty arthritis, including the joint circumference, infiltration of neutrophils in knee joints, and production of IL-1beta, TNF-alpha, and elastase. Uric Acid 72-75 tumor necrosis factor Rattus norvegicus 208-217
30592318-13 2019 CONCLUSIONS: These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-kappaB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis. Uric Acid 80-83 NLR family, pyrin domain containing 3 Rattus norvegicus 124-129
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 solute carrier family 22 member 8 Homo sapiens 125-129
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 solute carrier family 22 member 9 Homo sapiens 131-135
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 solute carrier family 22 member 12 Homo sapiens 137-142
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 BCR pseudogene 1 Homo sapiens 151-155
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 ATP binding cassette subfamily C member 4 Homo sapiens 157-161
30382560-5 2019 The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. Uric Acid 31-40 solute carrier family 17 member 1 Homo sapiens 163-167
30941135-5 2019 Here, we assessed the role of alpha2BAR in the monosodium urate (MSU) crystals-induced peritonitis that mimics human gout by using the alpha2BAR-overexpressing mice (alpha2BAR-Tg). Uric Acid 47-63 adrenoceptor alpha 2B Homo sapiens 30-39
30803894-5 2019 On a HFD however, NT5C2 knockout (NT5C2-/-) mice displayed reduced body/fat weight gain, improved glucose tolerance, reduced plasma insulin, triglyceride and uric acid levels compared with wild-type (WT) mice. Uric Acid 158-167 5'-nucleotidase, cytosolic II Mus musculus 18-23
30787218-0 2019 Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Uric Acid 0-9 potassium voltage-gated channel subfamily A member 5 Homo sapiens 34-39
30787218-0 2019 Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Uric Acid 0-9 AKT serine/threonine kinase 1 Homo sapiens 88-91
30787218-0 2019 Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Uric Acid 0-9 heat shock transcription factor 1 Homo sapiens 92-96
30787218-0 2019 Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Uric Acid 0-9 heat shock protein family A (Hsp70) member 4 Homo sapiens 97-102
30787218-1 2019 BACKGROUND: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced enhancement of Kv1.5 expression remain unclear. Uric Acid 26-35 potassium voltage-gated channel subfamily A member 5 Homo sapiens 105-110
30787218-1 2019 BACKGROUND: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced enhancement of Kv1.5 expression remain unclear. Uric Acid 26-35 potassium voltage-gated channel subfamily A member 5 Homo sapiens 172-177
30787218-1 2019 BACKGROUND: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced enhancement of Kv1.5 expression remain unclear. Uric Acid 139-148 potassium voltage-gated channel subfamily A member 5 Homo sapiens 105-110
30787218-1 2019 BACKGROUND: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced enhancement of Kv1.5 expression remain unclear. Uric Acid 139-148 potassium voltage-gated channel subfamily A member 5 Homo sapiens 172-177
30787218-2 2019 Methods and Results: The effects of uric acid on mRNA and protein levels of Kv1.5, as well as those of Akt, HSF1 and Hsp70, in HL-1 cardiomyocytes were studied by using qRT-PCR and Western blotting. Uric Acid 36-45 potassium voltage-gated channel subfamily A member 5 Homo sapiens 76-81
30787218-5 2019 Uric acid up-taken by HL-1 cells significantly increased the level of Kv1.5 proteins in a concentration-dependent manner, with this increase abolished by an uric acid transporter inhibitor. Uric Acid 0-9 potassium voltage-gated channel subfamily A member 5 Homo sapiens 70-75
30787218-6 2019 Uric acid slowed degradation of Kv1.5 proteins without altering its mRNA level. Uric Acid 0-9 potassium voltage-gated channel subfamily A member 5 Homo sapiens 32-37
30787218-7 2019 Uric acid enhanced phosphorylation of Akt and HSF1, and thereby increased both transcription and translation of Hsp70; these effects were abolished by a PI3K inhibitor. Uric Acid 0-9 AKT serine/threonine kinase 1 Homo sapiens 38-41
30787218-7 2019 Uric acid enhanced phosphorylation of Akt and HSF1, and thereby increased both transcription and translation of Hsp70; these effects were abolished by a PI3K inhibitor. Uric Acid 0-9 heat shock transcription factor 1 Homo sapiens 46-50
30787218-7 2019 Uric acid enhanced phosphorylation of Akt and HSF1, and thereby increased both transcription and translation of Hsp70; these effects were abolished by a PI3K inhibitor. Uric Acid 0-9 heat shock protein family A (Hsp70) member 4 Homo sapiens 112-117
30787218-8 2019 Hsp70 knockdown abolished the uric acid-induced increases of Kv1.5 proteins and channel currents. Uric Acid 30-39 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5
30787218-8 2019 Hsp70 knockdown abolished the uric acid-induced increases of Kv1.5 proteins and channel currents. Uric Acid 30-39 potassium voltage-gated channel subfamily A member 5 Homo sapiens 61-66
30787218-9 2019 CONCLUSIONS: Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70. Uric Acid 27-36 potassium voltage-gated channel subfamily A member 5 Homo sapiens 53-58
30787218-9 2019 CONCLUSIONS: Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70. Uric Acid 27-36 AKT serine/threonine kinase 1 Homo sapiens 95-98
30787218-9 2019 CONCLUSIONS: Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70. Uric Acid 27-36 heat shock transcription factor 1 Homo sapiens 103-107
30787218-9 2019 CONCLUSIONS: Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70. Uric Acid 27-36 heat shock protein family A (Hsp70) member 4 Homo sapiens 142-147
30562604-3 2019 The multidrug resistance protein 4 (MRP4), an organic anion transporter in birds has unique role in unidirectional efflux of urate into proximal renal tubular lumen for excretion and maintenance of homeostasis. Uric Acid 125-130 ATP binding cassette subfamily C member 4 Gallus gallus 4-34
30562604-3 2019 The multidrug resistance protein 4 (MRP4), an organic anion transporter in birds has unique role in unidirectional efflux of urate into proximal renal tubular lumen for excretion and maintenance of homeostasis. Uric Acid 125-130 ATP binding cassette subfamily C member 4 Gallus gallus 36-40
30810330-8 2019 According to the multivariate logistic regression analysis, the top third of uric acid level was independently associated with steatosis (adjusted hazard ratio 1.7; CI 95%: 1.05-2.8) and NASH (adjusted hazard ratio 1.8; CI 95%: 1.08-3.0) but not with advanced fibrosis (F2-F4) (adjusted hazard ratio 1.09; CI 95%: 0.63-1.87). Uric Acid 77-86 SAM domain, SH3 domain and nuclear localization signals 1 Homo sapiens 187-191
30810330-9 2019 CONCLUSION: higher levels of serum uric acid were independently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Uric Acid 35-44 SAM domain, SH3 domain and nuclear localization signals 1 Homo sapiens 109-113
30894219-1 2019 BACKGROUND: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Uric Acid 37-42 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 12-17
30894219-1 2019 BACKGROUND: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Uric Acid 90-95 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 12-17
30941135-5 2019 Here, we assessed the role of alpha2BAR in the monosodium urate (MSU) crystals-induced peritonitis that mimics human gout by using the alpha2BAR-overexpressing mice (alpha2BAR-Tg). Uric Acid 65-68 adrenoceptor alpha 2B Homo sapiens 30-39
30941135-6 2019 We found that the number of recruited neutrophils was significantly increased in the alpha2BAR-Tg mice after MSU treatment, when compared with wild type mice. Uric Acid 109-112 adrenergic receptor, alpha 2b Mus musculus 85-94
30551216-2 2019 First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e., SLC2A9, SLC22A12, ABCG2) on the association between fractional excretion of uric acid (FEUA) and urinary albumin/creatinine ratio (uACR). Uric Acid 172-181 solute carrier family 2 member 9 Homo sapiens 96-102
30651350-0 2019 Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. Uric Acid 0-9 aldo-keto reductase family 1 member B1 Rattus norvegicus 20-36
30769179-4 2019 Commercially, there are three kinds of agents targeting at urate-lowering, xanthine oxidoreductase inhibitor which prevents the production of UA, uricosuric which increases the concentration of UA in urine thus decreasing serum UA level, and uricase which converts UA to allantoin resulting in the dramatic decrement of serum UA. Uric Acid 142-144 xanthine dehydrogenase Homo sapiens 75-98
31592404-7 2019 On the other hand, patients with reduced eGFR significantly increased over time, although the statistical significance disappeared after adjustment for the covariates, including levels of serum uric acid and hemoglobin and use of renin-angiotensin inhibitors. Uric Acid 194-203 epidermal growth factor receptor Homo sapiens 41-45
30651350-5 2019 We evaluated whether soluble uric acid regulates aldose reductase expression both in cultured hepatocytes (HepG2 cells) and in the liver of hyperuricemic rats and whether this stimulation is associated with endogenous fructose production and fat accumulation. Uric Acid 29-38 aldo-keto reductase family 1 member B Homo sapiens 49-65
30651350-6 2019 Uric acid dose-dependently stimulated aldose reductase expression in the HepG2 cells, and this stimulation was associated with endogenous fructose production and triglyceride accumulation. Uric Acid 0-9 aldo-keto reductase family 1 member B Homo sapiens 38-54
30651350-10 2019 These results suggest that uric acid generated during fructose metabolism may act as a positive feedback mechanism that stimulates endogenous fructose production by stimulating aldose reductase in the polyol pathway. Uric Acid 27-36 aldo-keto reductase family 1 member B1 Rattus norvegicus 177-193
30993112-10 2019 In conclusion, telmisartan could ameliorate uric acid-induced EMT in NRK-52E cells likely through inhibition of the NADPH oxidase/ERK1/2/ET-1 pathway. Uric Acid 44-53 mitogen activated protein kinase 3 Rattus norvegicus 130-136
30718300-0 2019 The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals. Uric Acid 99-115 pentraxin related gene Mus musculus 9-20
30993112-10 2019 In conclusion, telmisartan could ameliorate uric acid-induced EMT in NRK-52E cells likely through inhibition of the NADPH oxidase/ERK1/2/ET-1 pathway. Uric Acid 44-53 endothelin 1 Rattus norvegicus 137-141
30993112-3 2019 Treatment with uric acid increased the expression of alpha-SMA, decreased the expression of E-cadherin, and promoted EMT in NRK-52E cells. Uric Acid 15-24 cadherin 1 Rattus norvegicus 92-102
30993112-4 2019 Uric acid treatment also led to increased endothelin-1 (ET-1) production, activation of extracellular-regulated protein kinase 1/2 (ERK1/2), and the upregulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). Uric Acid 0-9 endothelin 1 Rattus norvegicus 42-54
30690059-0 2019 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. Uric Acid 19-24 superoxide dismutase 1 Homo sapiens 39-44
30993112-4 2019 Uric acid treatment also led to increased endothelin-1 (ET-1) production, activation of extracellular-regulated protein kinase 1/2 (ERK1/2), and the upregulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). Uric Acid 0-9 endothelin 1 Rattus norvegicus 56-60
30993112-4 2019 Uric acid treatment also led to increased endothelin-1 (ET-1) production, activation of extracellular-regulated protein kinase 1/2 (ERK1/2), and the upregulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). Uric Acid 0-9 mitogen activated protein kinase 3 Rattus norvegicus 132-138
30993112-4 2019 Uric acid treatment also led to increased endothelin-1 (ET-1) production, activation of extracellular-regulated protein kinase 1/2 (ERK1/2), and the upregulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). Uric Acid 0-9 NADPH oxidase 4 Rattus norvegicus 165-218
30993112-4 2019 Uric acid treatment also led to increased endothelin-1 (ET-1) production, activation of extracellular-regulated protein kinase 1/2 (ERK1/2), and the upregulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). Uric Acid 0-9 NADPH oxidase 4 Rattus norvegicus 220-224
30993112-5 2019 Use of ET-1 receptor inhibitor (BQ123 or BQ788) could inhibit uric acid-induced EMT in NRK-52E cells. Uric Acid 62-71 endothelin 1 Rattus norvegicus 7-11
30993112-6 2019 Pretreatment with the ERK inhibitor (U0126 or PD98059) suppressed the release of ET-1 and EMT induced by uric acid. Uric Acid 105-114 Eph receptor B1 Rattus norvegicus 22-25
30993112-6 2019 Pretreatment with the ERK inhibitor (U0126 or PD98059) suppressed the release of ET-1 and EMT induced by uric acid. Uric Acid 105-114 endothelin 1 Rattus norvegicus 81-85
30993112-8 2019 These findings suggested that uric acid-induced EMT in renal tubular epithelial cells occurs through NADPH oxidase-mediated ERK1/2 activation and the subsequent release of ET-1. Uric Acid 30-39 mitogen activated protein kinase 3 Rattus norvegicus 124-130
30993112-8 2019 These findings suggested that uric acid-induced EMT in renal tubular epithelial cells occurs through NADPH oxidase-mediated ERK1/2 activation and the subsequent release of ET-1. Uric Acid 30-39 endothelin 1 Rattus norvegicus 172-176
32462103-6 2019 Finally, we employed molecular docking and bioinformatics to identify residues likely critical for recognition of myo-inositol by GLUT13 and urate by GLUT9. Uric Acid 141-146 solute carrier family 2 member 9 Homo sapiens 150-155
30566000-2 2019 It remains unknown whether enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 methyltransferase, can regulate metabolism of serum uric acid and progression of renal injury induced by hyperuricemia. Uric Acid 138-147 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 27-54
30566000-2 2019 It remains unknown whether enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 methyltransferase, can regulate metabolism of serum uric acid and progression of renal injury induced by hyperuricemia. Uric Acid 138-147 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 56-60
31028067-0 2019 The Association between Serum Uric Acid Levels and Insulin Resistance and Secretion in Prediabetes Mellitus: A Cross-Sectional Study. Uric Acid 30-39 insulin Homo sapiens 51-58
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 ATP binding cassette subfamily G member 2 Rattus norvegicus 82-117
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 ATP binding cassette subfamily G member 2 Rattus norvegicus 119-124
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 solute carrier family 22 member 6 Rattus norvegicus 127-154
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 solute carrier family 22 member 6 Rattus norvegicus 156-160
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 solute carrier family 22 member 5 Rattus norvegicus 203-242
30579255-18 2019 The mechanism of SGF promoting uric acid excretion was related to its increase of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic anion transporters 2 (OCT2) and organic cation/carnitine transporters 2 (OCTN2) expression. Uric Acid 31-40 solute carrier family 22 member 5 Rattus norvegicus 244-249
30690059-2 2019 The aim of the present study was to investigate the potential neuroprotective effects and mechanisms of urate, an important endogenous antioxidant and a biomarker of favorable ALS progression rates, in the mutant human SOD1-related cellular and Drosophila models of ALS. Uric Acid 104-109 superoxide dismutase 1 Homo sapiens 219-223
30690059-3 2019 Our results showed that urate treatment provided neuroprotective effects as confirmed by enhanced survival, attenuated motor impairments, reduced oxidative damage and increased antioxidant defense in hSOD1-G85R-expressing Drosophila models of ALS. Uric Acid 24-29 superoxide dismutase 1 Homo sapiens 200-205
30690059-4 2019 In vitro studies, we demonstrated that urate protected motor neurons (NSC-34 cells) against hSOD1-G93A-induced cell damage and apoptosis by decreasing reactive oxygen specials (ROS) production and oxidative damage. Uric Acid 39-44 superoxide dismutase 1 Homo sapiens 92-97
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 cap-n-collar Drosophila melanogaster 68-111
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 cap-n-collar Drosophila melanogaster 113-117
30566000-3 2019 In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR), and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Uric Acid 137-146 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 48-52
30566000-3 2019 In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR), and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Uric Acid 137-146 SMAD family member 3 Mus musculus 206-211
30566000-3 2019 In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR), and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Uric Acid 137-146 epidermal growth factor receptor Mus musculus 213-245
30566000-3 2019 In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR), and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Uric Acid 137-146 epidermal growth factor receptor Mus musculus 247-251
30566000-3 2019 In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR), and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Uric Acid 137-146 mitogen-activated protein kinase 3 Mus musculus 314-320
30566000-8 2019 Collectively, EZH2 inhibition can reduce the level of serum uric acid and alleviate renal injury and fibrosis through a mechanism associated with inhibition of multiple signaling pathways. Uric Acid 60-69 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 14-18
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 cap-n-collar Drosophila melanogaster 131-135
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster 162-207
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster 209-213
30632646-2 2019 Several recent studies have demonstrated a significant decrease of serum urate during acute gout attack, which is an aseptic inflammation process focusing on IL-1beta. Uric Acid 73-78 interleukin 1 beta Homo sapiens 158-166
30690059-0 2019 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. Uric Acid 19-24 Akt1 Drosophila melanogaster 163-166
30690059-0 2019 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. Uric Acid 19-24 Pk34A Drosophila melanogaster 167-175
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 Akt1 Drosophila melanogaster 274-277
30690059-0 2019 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. Uric Acid 19-24 cap-n-collar Drosophila melanogaster 176-180
30690059-5 2019 Moreover, urate markedly increased the expression and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), stimulated Nrf2-targeted antioxidant gene glutathione cysteine ligase catalytic subunit (GCLC) expression and glutathione (GSH) synthesis by upregulating Akt/GSK3beta pathway. Uric Acid 10-15 Pk34A Drosophila melanogaster 278-286
30690059-0 2019 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. Uric Acid 19-24 Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster 181-185
30690059-6 2019 Furthermore, the inhibition of Akt pathway with LY294002 abolished urate-mediated elevation of GSH synthesis and neuroprotective effects both in vivo and in vitro. Uric Acid 67-72 Akt1 Drosophila melanogaster 31-34
30664190-0 2019 Adiponectin protects against uric acid-induced renal tubular epithelial inflammatory responses via the AdipoR1/AMPK signaling pathway. Uric Acid 29-38 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
30690059-7 2019 Overall, these results suggested that, in addition to its direct scavenging of ROS, urate markedly enhanced GSH expression by activating Akt/GSK3beta/Nrf2/GCLC pathway, and thus offering neuroprotective effects on motor neurons against oxidative stress. Uric Acid 84-89 Akt1 Drosophila melanogaster 137-140
30690059-7 2019 Overall, these results suggested that, in addition to its direct scavenging of ROS, urate markedly enhanced GSH expression by activating Akt/GSK3beta/Nrf2/GCLC pathway, and thus offering neuroprotective effects on motor neurons against oxidative stress. Uric Acid 84-89 Pk34A Drosophila melanogaster 141-149
30690059-7 2019 Overall, these results suggested that, in addition to its direct scavenging of ROS, urate markedly enhanced GSH expression by activating Akt/GSK3beta/Nrf2/GCLC pathway, and thus offering neuroprotective effects on motor neurons against oxidative stress. Uric Acid 84-89 cap-n-collar Drosophila melanogaster 150-154
30690059-7 2019 Overall, these results suggested that, in addition to its direct scavenging of ROS, urate markedly enhanced GSH expression by activating Akt/GSK3beta/Nrf2/GCLC pathway, and thus offering neuroprotective effects on motor neurons against oxidative stress. Uric Acid 84-89 Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster 155-159
30148447-2 2019 This study determined monosodium urate crystal-induced MIF production and its interaction with interleukin (IL)-8 in gout. Uric Acid 22-38 C-X-C motif chemokine ligand 8 Homo sapiens 95-113
30148447-2 2019 This study determined monosodium urate crystal-induced MIF production and its interaction with interleukin (IL)-8 in gout. Uric Acid 22-38 macrophage migration inhibitory factor Homo sapiens 55-58
30664190-0 2019 Adiponectin protects against uric acid-induced renal tubular epithelial inflammatory responses via the AdipoR1/AMPK signaling pathway. Uric Acid 29-38 adiponectin receptor 1 Homo sapiens 103-110
30664190-0 2019 Adiponectin protects against uric acid-induced renal tubular epithelial inflammatory responses via the AdipoR1/AMPK signaling pathway. Uric Acid 29-38 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 111-115
30664190-4 2019 In the present study, human PTECs were incubated with 100 microg/ml soluble (S) UA in the presence or absence of globular (g) APN, APN receptor 1 (AdipoR1)-short hairpin RNA lentivirus or compound C. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays were performed to assess APN mRNA expression. Uric Acid 80-82 adiponectin receptor 1 Homo sapiens 147-154
30507858-0 2019 Caspase-(8/3) activation and organ inflammation in a rat model of resuscitated hemorrhagic shock: A role for uric acid. Uric Acid 109-118 caspase 8 Rattus norvegicus 0-12
30637441-0 2019 Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes. Uric Acid 54-57 spleen associated tyrosine kinase Homo sapiens 15-18
30637441-2 2019 In humans, the induction of IL-1beta production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. Uric Acid 56-59 interleukin 1 alpha Homo sapiens 28-36
30637441-2 2019 In humans, the induction of IL-1beta production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. Uric Acid 56-59 NLR family pyrin domain containing 3 Homo sapiens 68-73
30637441-5 2019 Here, we show that resveratrol suppresses secretion of active IL-1beta by human primary monocytes stimulated with MSU crystals through suppression of Syk activation. Uric Acid 114-117 interleukin 1 alpha Homo sapiens 62-70
30637441-5 2019 Here, we show that resveratrol suppresses secretion of active IL-1beta by human primary monocytes stimulated with MSU crystals through suppression of Syk activation. Uric Acid 114-117 spleen associated tyrosine kinase Homo sapiens 150-153
30604288-7 2019 These results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney. Uric Acid 121-126 solute carrier family 5 member 8 Homo sapiens 32-37
30604288-7 2019 These results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney. Uric Acid 121-126 PDZ domain containing 1 Homo sapiens 38-43
30103843-8 2019 The results showed that 100-fold of Na+, K+, Mg2+, Ca2+, Cl-, SO42-, sorbitol, sucrose, fructose, citric acid, 40-fold of NO3-, glucose, sucrose, urea, and 10-fold of uric acid had no significant interference. Uric Acid 167-176 NBL1, DAN family BMP antagonist Homo sapiens 122-125
30637441-7 2019 Resveratrol also inhibited NLRP3 inflammasome activation in MSU-stimulated monocytes by suppressing oligomerization of ASC. Uric Acid 60-63 NLR family pyrin domain containing 3 Homo sapiens 27-32
30637441-7 2019 Resveratrol also inhibited NLRP3 inflammasome activation in MSU-stimulated monocytes by suppressing oligomerization of ASC. Uric Acid 60-63 PYD and CARD domain containing Homo sapiens 119-122
30507858-11 2019 In vitro, caspases-(8/3) activity was tested in epithelial cells exposed to UA. Uric Acid 76-78 caspase 8 Rattus norvegicus 10-23
30507858-14 2019 The exogenous UA administration in sham animals reproduced the activation of caspase-8 and MPO in organs, and TNF-alpha in the lung. Uric Acid 14-16 caspase 8 Rattus norvegicus 77-86
30507858-14 2019 The exogenous UA administration in sham animals reproduced the activation of caspase-8 and MPO in organs, and TNF-alpha in the lung. Uric Acid 14-16 myeloperoxidase Rattus norvegicus 91-94
30507858-14 2019 The exogenous UA administration in sham animals reproduced the activation of caspase-8 and MPO in organs, and TNF-alpha in the lung. Uric Acid 14-16 tumor necrosis factor Rattus norvegicus 110-119
30507858-16 2019 In vitro, soluble UA induced caspases-(3/8) activity in epithelial cells. Uric Acid 18-20 caspase 3 Rattus norvegicus 29-42
30630716-1 2019 The xanthine oxidase (XO) plays an important role in producing uric acid, and therefore XO inhibitors are considered as one of the promising therapies for hyperuricemia and gout. Uric Acid 63-72 xanthine dehydrogenase Mus musculus 4-20
30576885-2 2019 Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals. Uric Acid 27-29 urate oxidase (pseudogene) Homo sapiens 61-74
30576885-2 2019 Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals. Uric Acid 27-29 urate oxidase (pseudogene) Homo sapiens 76-79
30576885-3 2019 Here, we show that male and female mice with UOX haploinsufficiency exhibit an age-related elevation of UA levels, and that the life span of female but not male UOX+/- mice is significantly increased compared to wild-type mice. Uric Acid 104-106 urate oxidase Mus musculus 45-48
30576885-4 2019 Serum UA levels are elevated in response to treadmill exercise in UOX+/- mice, but not wild-type mice, and the endurance of the UOX+/- mice is significantly greater than wild-type mice. Uric Acid 6-8 urate oxidase Mus musculus 66-69
30576885-6 2019 Levels of oxidative protein nitration and lipid peroxidation are reduced in muscle and brain tissues of UOX+/- mice under conditions of metabolic and oxidative stress (running in the case of muscle and ischemia in the case of the brain), consistent with prior evidence that UA can scavenge peroxynitrite and hydroxyl radical. Uric Acid 274-276 urate oxidase Mus musculus 104-107
30837873-8 2019 Similarly, beneficial effects have been seen in heart, skeletal muscle, or brain after treatment with allopurinol or febuxostat to inhibit xanthine oxidoreductase, which catalyzes hypoxanthine -> xanthine and xanthine -> urate reactions. Uric Acid 227-232 xanthine dehydrogenase Homo sapiens 139-162
30782217-13 2019 CONCLUSIONS: Blood glucose fluctuation is an independent risk factor associated with CIMT in T2DM patients, in addition to conventional risk factors, such as smoking, high UA level and 2 h C-peptide. Uric Acid 172-174 CIMT Homo sapiens 85-89
30630716-1 2019 The xanthine oxidase (XO) plays an important role in producing uric acid, and therefore XO inhibitors are considered as one of the promising therapies for hyperuricemia and gout. Uric Acid 63-72 xanthine dehydrogenase Mus musculus 22-24
30963140-8 2019 In the whole study population, FGF21 associated positively with irisin and uric acid and negatively with leptin and high-density lipoprotein cholesterol (HDL-C). Uric Acid 75-84 fibroblast growth factor 21 Homo sapiens 31-36
30828314-1 2019 Objective: The objective of the present study was to meta-analyze relevant literature to gain a comprehensive understanding of the potential relationship between serum uric acid levels and risk of benign paroxysmal positional vertigo (BPPV). Uric Acid 168-177 benign paroxysmal positional vertigo Homo sapiens 235-239
30828314-2 2019 Methods: The databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were systematically searched for observational case-control studies of the association between BPPV and serum uric acid levels published up to October 2018. Uric Acid 232-241 benign paroxysmal positional vertigo Homo sapiens 217-221
30828314-5 2019 There was a strong tendency for serum uric acid levels to be associated with risk of BPPV among studies conducted in China (OR 0.69, 95%CI 0.01-1.40, p = 0.053), but not among studies outside China (OR 1.07, 95%CI 1.08-3.22, p = 0.33). Uric Acid 38-47 benign paroxysmal positional vertigo Homo sapiens 85-89
30828314-6 2019 Across all studies, serum uric acid level was significantly higher among individuals with BPPV than among controls (OR 0.78, 95%CI 0.15-1.41, p = 0.015), yet it did not independently predict risk of the disorder (OR 1.003, 95%CI 0.995-1.012, p = 0.471). Uric Acid 26-35 benign paroxysmal positional vertigo Homo sapiens 90-94
30828314-7 2019 Conclusion: The available evidence suggests that BPPV is associated with elevated levels of serum uric acid, but these levels may not be an independent risk factor of BPPV. Uric Acid 98-107 benign paroxysmal positional vertigo Homo sapiens 49-53
30740669-0 2019 Uric acid induced epithelial-mesenchymal transition of renal tubular cells through PI3K/p-Akt signaling pathway. Uric Acid 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 90-93
30740669-2 2019 We hereby intend to investigate whether PI3K/p-Akt signaling plays a role in uric-acid induced epithelial-mesenchymal transition process. Uric Acid 77-86 AKT serine/threonine kinase 1 Rattus norvegicus 47-50
30740669-6 2019 We found that uric acid induced visible morphological alterations in NRK-52E cells accompanied by increased expression of alpha-smooth muscle actin and reduced expression of E-cadherin. Uric Acid 14-23 actin gamma 2, smooth muscle Rattus norvegicus 122-147
30740669-6 2019 We found that uric acid induced visible morphological alterations in NRK-52E cells accompanied by increased expression of alpha-smooth muscle actin and reduced expression of E-cadherin. Uric Acid 14-23 cadherin 1 Rattus norvegicus 174-184
30740669-9 2019 These findings demonstrated that high uric acid could induce phenotypic transition of cultured renal tubular cells, which was probably via activating PI3K/p-Akt signaling pathway. Uric Acid 38-47 AKT serine/threonine kinase 1 Rattus norvegicus 157-160
30710491-4 2019 RESULTS The BPPV group had higher levels of cholesterol and uric acid than in the control group (p<0.05). Uric Acid 60-69 benign paroxysmal positional vertigo Homo sapiens 12-16
30728075-5 2019 METHODS: Peripheral blood mononuclear cells (PBMCs) were cultured with a combination of monosodium urate crystals (MSU) and palmitic acid (C16.0) in order to activate the NLRP3 inflammasome and induce IL-1beta production. Uric Acid 88-104 NLR family pyrin domain containing 3 Homo sapiens 171-176
30710491-5 2019 The cholesterol and uric acid levels were positively correlated with BPPV (p<0.05) [odds ratio (OR)=2.298 (1.252-4.350), 95% confidence interval (95% CI)=1.123 (0.987-1.987)]. Uric Acid 20-29 benign paroxysmal positional vertigo Homo sapiens 69-73
30710491-7 2019 In the BPPV group, cholesterol and uric acid levels of TT genotype were elevated compared with those in GG genotype (p<0.05). Uric Acid 35-44 benign paroxysmal positional vertigo Homo sapiens 7-11
30710491-8 2019 CONCLUSIONS The onset of BPPV is related to the increased levels of cholesterol and uric acid, as well as the dominant homozygous mutation of rs2074880 (T/G) in the CACNA1A gene. Uric Acid 84-93 benign paroxysmal positional vertigo Homo sapiens 25-29
30347231-0 2019 LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. Uric Acid 55-64 CDKN2B antisense RNA 1 Homo sapiens 7-12
30347231-0 2019 LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. Uric Acid 55-64 NLR family pyrin domain containing 3 Homo sapiens 22-27
30347231-9 2019 ANRIL and BRCC3 were highly expressed while miR-122-5p was down-regulated in serum of UAN patients and uric acid-treated tubular epithelial cells. Uric Acid 103-112 CDKN2B antisense RNA 1 Homo sapiens 0-5
30347231-0 2019 LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. Uric Acid 55-64 microRNA 1225 Homo sapiens 85-95
30347231-9 2019 ANRIL and BRCC3 were highly expressed while miR-122-5p was down-regulated in serum of UAN patients and uric acid-treated tubular epithelial cells. Uric Acid 103-112 microRNA 1225 Homo sapiens 44-54
30347231-0 2019 LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. Uric Acid 55-64 BRCA1/BRCA2-containing complex subunit 3 Homo sapiens 96-101
30347231-1 2019 This study is designed to explore the mechanism by which long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) plays a pathogenic role in uric acid nephropathy (UAN). Uric Acid 164-173 cyclin dependent kinase inhibitor 2A Homo sapiens 118-122
30347231-1 2019 This study is designed to explore the mechanism by which long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) plays a pathogenic role in uric acid nephropathy (UAN). Uric Acid 164-173 CDKN2B antisense RNA 1 Homo sapiens 130-135
30557836-0 2019 Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid. Uric Acid 135-144 dipeptidylpeptidase 4 Rattus norvegicus 0-22
30853986-7 2019 Under the optimum conditions, our disposable nonenzymatic screen-printed electrode for the determination of uric acid shows the acceptable analytical performance in a wide range of linearity (2.5-1,000 muM) with a low detection limit of 0.74 muM. Uric Acid 108-117 latexin Homo sapiens 202-205
30853986-7 2019 Under the optimum conditions, our disposable nonenzymatic screen-printed electrode for the determination of uric acid shows the acceptable analytical performance in a wide range of linearity (2.5-1,000 muM) with a low detection limit of 0.74 muM. Uric Acid 108-117 latexin Homo sapiens 242-245
30557836-3 2019 We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Uric Acid 196-205 dipeptidylpeptidase 4 Rattus norvegicus 32-37
30557836-3 2019 We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Uric Acid 196-205 adenosine deaminase Rattus norvegicus 167-170
30557836-9 2019 However, DPP-4 inhibition significantly ameliorated these alterations induced by COC treatment through suppression of uric acid (plasma; 15.1 +- 1.0 mg/dl, hepatic; 75.6 +- 5.0 mg/100 mg tissue), XO (plasma; 4.1 +- 0.9 U/L, hepatic; 8.7 +- 0.4 U/g protein), ADA and DPP-4 activities suggesting their involvement in glucose dysregulation and hepatic TG accumulation induced by COC treatment. Uric Acid 118-127 dipeptidylpeptidase 4 Rattus norvegicus 9-14
30557836-10 2019 Therefore, DPP-4 inhibition would impact positively on cardiometabolic disorders, at least in part, through XO, ADA and uric acid suppression. Uric Acid 120-129 dipeptidylpeptidase 4 Rattus norvegicus 11-16
30415113-7 2019 Additionally, metabolites associated with oxidative stress and mitochondrial dysfunction were greatly elevated in PCB 126 exposed mice with compromised livers (e.g., 4-hydroxy-nonenal glutathione, oxylipids, uric acid, and acylcarnitines). Uric Acid 208-217 pyruvate carboxylase Mus musculus 114-117
30387921-0 2019 LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression. Uric Acid 47-63 nuclear factor of activated T cells 1 Homo sapiens 115-121
30387921-0 2019 LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression. Uric Acid 47-63 Janus kinase 3 Homo sapiens 7-11
30622076-9 2019 Furthermore, exposure to Cadmium, PCB-138, and to PCB-153 was positively associated with uric acid levels. Uric Acid 89-98 pyruvate carboxylase Homo sapiens 34-37
30622076-9 2019 Furthermore, exposure to Cadmium, PCB-138, and to PCB-153 was positively associated with uric acid levels. Uric Acid 89-98 pyruvate carboxylase Homo sapiens 50-53
30622076-11 2019 WQS analyses revealed a major contribution of PCB-153 within the PCB mixture on both the risk of hyperuricemia and uric acid levels. Uric Acid 115-124 pyruvate carboxylase Homo sapiens 46-49
30622076-11 2019 WQS analyses revealed a major contribution of PCB-153 within the PCB mixture on both the risk of hyperuricemia and uric acid levels. Uric Acid 115-124 pyruvate carboxylase Homo sapiens 65-68
30387921-0 2019 LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression. Uric Acid 47-63 Janus kinase 3 Homo sapiens 12-16
30387921-0 2019 LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression. Uric Acid 47-63 cathepsin K Homo sapiens 122-126
30247644-10 2019 This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells from AG patients compared with those of controls, and the uric acid-caused dose-relevant and time-dependent activation of 5-lipoxygenase and CYP4F3 at the transcriptional and molecular levels in vitro. Uric Acid 177-186 arachidonate 5-lipoxygenase Homo sapiens 72-86
30576922-4 2019 The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 72-75
30576922-4 2019 The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Uric Acid 49-58 insulin Homo sapiens 136-143
30205779-11 2019 Similarly, after adjusting for all potential confounders, eGFR, glucose, age and serum uric acid levels, (OR 1.26 (95% CI 1.04 -1.52, p1/40.01), were identified as independent predictors for having a intima to media thickness >=1 mm. Uric Acid 87-96 epidermal growth factor receptor Homo sapiens 58-62
31485187-0 2019 Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus: A systematic review with an indirect comparison meta-analysis. Uric Acid 62-71 solute carrier family 5 member 2 Homo sapiens 11-41
31485187-1 2019 To describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 87-96 solute carrier family 5 member 2 Homo sapiens 27-58
31485187-1 2019 To describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 87-96 solute carrier family 5 member 2 Homo sapiens 60-65
30247644-10 2019 This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells from AG patients compared with those of controls, and the uric acid-caused dose-relevant and time-dependent activation of 5-lipoxygenase and CYP4F3 at the transcriptional and molecular levels in vitro. Uric Acid 177-186 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-97
30247644-10 2019 This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells from AG patients compared with those of controls, and the uric acid-caused dose-relevant and time-dependent activation of 5-lipoxygenase and CYP4F3 at the transcriptional and molecular levels in vitro. Uric Acid 177-186 arachidonate 5-lipoxygenase Homo sapiens 241-255
30247644-10 2019 This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells from AG patients compared with those of controls, and the uric acid-caused dose-relevant and time-dependent activation of 5-lipoxygenase and CYP4F3 at the transcriptional and molecular levels in vitro. Uric Acid 177-186 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 260-266
30626429-11 2019 CONCLUSIONS: In a large population of European ancestry, ABCG2 and PDZK1 gene-sex interactions exist for gout risk, with the serum urate-raising alleles exerting a greater influence on gout risk in men than in women. Uric Acid 131-136 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 57-62
30809550-9 2019 The multivariate logistic regression showed that cyt c was an independent risk factor for the occurrence of CIN (OR, 7.421; 95% CI, 6.471-20.741; P = 0.034) after adjusting for age, history of hypertension and diabetes mellitus, levels of creatinine, uric acid, and glucose. Uric Acid 251-260 cytochrome c, somatic Homo sapiens 49-54
30719032-0 2018 Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Uric Acid 11-16 long intergenic non-protein coding RNA 1229 Homo sapiens 78-87
30719032-0 2018 Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Uric Acid 11-16 MAF transcriptional regulator RNA Homo sapiens 92-98
30719032-3 2018 Here, we investigate the function of two independent serum urate-associated signals (SUA1 and SUA2) in close proximity to lincRNAs and an enhancer that reside ~60 kb and ~300 kb upstream of MAF, respectively. Uric Acid 59-64 SUMO1 activating enzyme subunit 1 Homo sapiens 85-89
30719032-5 2018 We have also identified that variants within SUA1 are trans-eQTL for genes that are active in kidney- and serum urate-relevant pathways. Uric Acid 112-117 SUMO1 activating enzyme subunit 1 Homo sapiens 45-49
30719032-6 2018 Serum urate-associated variants rs4077450 and rs4077451 within SUA2 lie within an enhancer that recruits the transcription factor HNF4alpha and forms long range interactions with LINC01229 and MAFTRR. Uric Acid 6-11 hepatocyte nuclear factor 4 alpha Homo sapiens 130-139
30719032-6 2018 Serum urate-associated variants rs4077450 and rs4077451 within SUA2 lie within an enhancer that recruits the transcription factor HNF4alpha and forms long range interactions with LINC01229 and MAFTRR. Uric Acid 6-11 long intergenic non-protein coding RNA 1229 Homo sapiens 179-188
30719032-6 2018 Serum urate-associated variants rs4077450 and rs4077451 within SUA2 lie within an enhancer that recruits the transcription factor HNF4alpha and forms long range interactions with LINC01229 and MAFTRR. Uric Acid 6-11 MAF transcriptional regulator RNA Homo sapiens 193-199
30719032-7 2018 The urate-raising alleles of rs4077450 and rs4077451 increase enhancer activity and associate with increased expression of LINC01229. Uric Acid 4-9 long intergenic non-protein coding RNA 1229 Homo sapiens 123-132
30719032-10 2018 Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans. Uric Acid 52-57 long intergenic non-protein coding RNA 1229 Homo sapiens 131-140
30719032-10 2018 Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans. Uric Acid 52-57 MAF transcriptional regulator RNA Homo sapiens 145-151
30719032-10 2018 Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans. Uric Acid 52-57 solute carrier family 5 member 8 Homo sapiens 184-190
30719032-10 2018 Collectively, our results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans. Uric Acid 52-57 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 195-201
30675335-0 2019 Long non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats. Uric Acid 102-111 CDKN2B antisense RNA 1 Homo sapiens 20-25
30675335-1 2019 Background: The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats. Uric Acid 180-189 CDKN2B antisense RNA 1 Homo sapiens 140-145
30679647-1 2019 High serum uric acid (UA) has been reported to be associated with left ventricular (LV) dysfunction; however, the relationship between UA and plasma B-type natriuretic peptide (BNP), a sensitive biomarker of heart failure, is still unclear. Uric Acid 11-20 natriuretic peptide B Homo sapiens 149-175
30679647-1 2019 High serum uric acid (UA) has been reported to be associated with left ventricular (LV) dysfunction; however, the relationship between UA and plasma B-type natriuretic peptide (BNP), a sensitive biomarker of heart failure, is still unclear. Uric Acid 135-137 natriuretic peptide B Homo sapiens 149-175
30679647-1 2019 High serum uric acid (UA) has been reported to be associated with left ventricular (LV) dysfunction; however, the relationship between UA and plasma B-type natriuretic peptide (BNP), a sensitive biomarker of heart failure, is still unclear. Uric Acid 135-137 natriuretic peptide B Homo sapiens 177-180
30679647-6 2019 UA was significantly associated with BNP in lean aged females, but not in obese adolescent males, although LVEF was significantly reduced in response to a high UA in both groups. Uric Acid 0-2 natriuretic peptide B Homo sapiens 37-40
30679935-0 2019 Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese. Uric Acid 62-71 solute carrier family 28 member 2 Homo sapiens 23-30
30634585-2 2019 Urate oxidase (UOx) can oxidize uric acid to hydrogen peroxide and allantoin, which provides a good opportunity for electrochemical detection for UA. Uric Acid 32-41 urate oxidase (pseudogene) Homo sapiens 0-13
30634585-2 2019 Urate oxidase (UOx) can oxidize uric acid to hydrogen peroxide and allantoin, which provides a good opportunity for electrochemical detection for UA. Uric Acid 32-41 urate oxidase (pseudogene) Homo sapiens 15-18
30634585-2 2019 Urate oxidase (UOx) can oxidize uric acid to hydrogen peroxide and allantoin, which provides a good opportunity for electrochemical detection for UA. Uric Acid 146-148 urate oxidase (pseudogene) Homo sapiens 0-13
30634585-2 2019 Urate oxidase (UOx) can oxidize uric acid to hydrogen peroxide and allantoin, which provides a good opportunity for electrochemical detection for UA. Uric Acid 146-148 urate oxidase (pseudogene) Homo sapiens 15-18
30634585-3 2019 Under the optimized conditions, the current changes by the UOx/Bull Serum Albumin (BSA)/BLG-MWCNTs-PtNPs/Glassy Carbon (GC) electrode with the electrochemical method was proportional to the concentration of UA. Uric Acid 207-209 urate oxidase (pseudogene) Homo sapiens 59-62
30626429-11 2019 CONCLUSIONS: In a large population of European ancestry, ABCG2 and PDZK1 gene-sex interactions exist for gout risk, with the serum urate-raising alleles exerting a greater influence on gout risk in men than in women. Uric Acid 131-136 PDZ domain containing 1 Homo sapiens 67-72
30488476-2 2019 Metformin is excreted into urine through active secretion mediated by rOCTs and rMATE1.The aim of this study was to identify the effects of high uric acid on the disposition and its mechanism. Uric Acid 145-154 solute carrier family 47 member 1 Rattus norvegicus 80-86
30502082-0 2019 Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling. Uric Acid 68-77 macrophage migration inhibitory factor Homo sapiens 12-50
30502082-0 2019 Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling. Uric Acid 68-77 macrophage migration inhibitory factor Homo sapiens 52-55
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 0-9 macrophage migration inhibitory factor Rattus norvegicus 43-81
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 0-9 macrophage migration inhibitory factor Rattus norvegicus 83-86
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 11-13 macrophage migration inhibitory factor Rattus norvegicus 43-81
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 11-13 macrophage migration inhibitory factor Rattus norvegicus 83-86
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 142-144 macrophage migration inhibitory factor Rattus norvegicus 43-81
30502082-2 2019 Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Uric Acid 142-144 macrophage migration inhibitory factor Rattus norvegicus 83-86
30502082-3 2019 Given that MIF is able to induce vascular smooth muscle cell (VSMC) de-differentiation (from contractile state to a secretory state), we thus hypothesized that UA-induced vascular injury is via up-regulating of MIF in VSMCs, which enhancing vascular inflammation and VSMC transition. Uric Acid 160-162 macrophage migration inhibitory factor Homo sapiens 11-14
30502082-3 2019 Given that MIF is able to induce vascular smooth muscle cell (VSMC) de-differentiation (from contractile state to a secretory state), we thus hypothesized that UA-induced vascular injury is via up-regulating of MIF in VSMCs, which enhancing vascular inflammation and VSMC transition. Uric Acid 160-162 macrophage migration inhibitory factor Homo sapiens 211-214
30502082-5 2019 We tested the efficacy of MIF inhibitor (10 mg/kg, twice/day, 14 days) on UA-induced vascular inflammation and remodeling. Uric Acid 74-76 macrophage migration inhibitory factor Homo sapiens 26-29
30502082-6 2019 High plasma level of UA induced vascular MIF release into the plasma at acute phase. Uric Acid 21-23 macrophage migration inhibitory factor Homo sapiens 41-44
30502082-8 2019 MIF inhibitor suppressed vascular inflammatory responses, repressed VSMC de-differentiation, and attenuated vascular remodeling and dysfunction following UA stimulation. Uric Acid 154-156 macrophage migration inhibitory factor Homo sapiens 0-3
30502082-9 2019 Knockdown of MIF in cultured VSMCs repressed UA-induced de-differentiation. Uric Acid 45-47 macrophage migration inhibitory factor Homo sapiens 13-16
30502082-10 2019 Our results provided a novel mechanism for MIF-mediated vascular injury in response to UA stimulation, and suggested that anti-MIF interventions may be of therapeutic value in hyperuricemic patients. Uric Acid 87-89 macrophage migration inhibitory factor Homo sapiens 43-46
30502082-10 2019 Our results provided a novel mechanism for MIF-mediated vascular injury in response to UA stimulation, and suggested that anti-MIF interventions may be of therapeutic value in hyperuricemic patients. Uric Acid 87-89 macrophage migration inhibitory factor Homo sapiens 127-130
31468393-0 2019 Taurine Inhibited Uric Acid Uptake in HK-2 Renal Tubular Epithelial Cells. Uric Acid 18-27 hexokinase 2 Homo sapiens 38-42
31468393-2 2019 The present study aims to investigate the effects of taurine on uric acid uptake in human renal proximal tubular epithelial cells (HK-2). Uric Acid 64-73 hexokinase 2 Homo sapiens 131-135
30427222-1 2019 Inhibitors of the Na+-glucose cotransporter SGLT2 enhance urinary glucose and urate excretion and lower plasma urate levels. Uric Acid 78-83 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 44-49
31192567-12 2019 High intakes of SSB, coffee or tea was associated with high serum uric acid values and worse dietary quality. Uric Acid 66-75 small RNA binding exonuclease protection factor La Homo sapiens 16-19
30551366-0 2019 Uric acid induced inflammatory responses in endothelial cells via up-regulating(pro)renin receptor. Uric Acid 0-9 ATPase H+ transporting accessory protein 2 Homo sapiens 84-98
30671426-13 2018 Multiple linear regression showed that the US-FLI score was significantly associated with the waist-to-height ratio, uric acid, adiponectin, and M30 levels (all p < 0.05) in children with obesity. Uric Acid 117-126 FLII actin remodeling protein Homo sapiens 46-49
30612459-3 2019 Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 beta in macrophages. Uric Acid 60-65 NLR family pyrin domain containing 3 Homo sapiens 82-87
30612459-3 2019 Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 beta in macrophages. Uric Acid 60-65 caspase 1 Homo sapiens 130-139
30612459-3 2019 Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 beta in macrophages. Uric Acid 60-65 interleukin 1 beta Homo sapiens 153-162
30488476-5 2019 For the in vitro study, HEK293 and HepaRG cells were used to investigate the effect of uric acid (15 mg/dl) on the expression of OCT1, OCT2 and MATE1 and the disposition of metformin, respectively. Uric Acid 87-96 solute carrier family 22 member 1 Homo sapiens 129-133
30488476-5 2019 For the in vitro study, HEK293 and HepaRG cells were used to investigate the effect of uric acid (15 mg/dl) on the expression of OCT1, OCT2 and MATE1 and the disposition of metformin, respectively. Uric Acid 87-96 POU class 2 homeobox 2 Homo sapiens 135-139
30488476-5 2019 For the in vitro study, HEK293 and HepaRG cells were used to investigate the effect of uric acid (15 mg/dl) on the expression of OCT1, OCT2 and MATE1 and the disposition of metformin, respectively. Uric Acid 87-96 solute carrier family 47 member 1 Homo sapiens 144-149
30488476-8 2019 The in vitro study showed that uric acid could upregulate the expression of OCT2 and MATE1 in HEK293 cells and MATE1 in HepaRG cells and increase the intracellular metformin concentration in these two cell lines. Uric Acid 31-40 POU class 2 homeobox 2 Homo sapiens 76-80
30606989-9 2019 We compared claudin expression patterns in urate-permeable and urate-non-permeable Caco-2 cells by LC/MS and found that claudin 12 had a higher expression level in urate-permeable Caco-2 cells. Uric Acid 43-48 claudin 12 Homo sapiens 120-130
30488476-8 2019 The in vitro study showed that uric acid could upregulate the expression of OCT2 and MATE1 in HEK293 cells and MATE1 in HepaRG cells and increase the intracellular metformin concentration in these two cell lines. Uric Acid 31-40 solute carrier family 47 member 1 Homo sapiens 85-90
30606989-9 2019 We compared claudin expression patterns in urate-permeable and urate-non-permeable Caco-2 cells by LC/MS and found that claudin 12 had a higher expression level in urate-permeable Caco-2 cells. Uric Acid 63-68 claudin 12 Homo sapiens 120-130
30606989-9 2019 We compared claudin expression patterns in urate-permeable and urate-non-permeable Caco-2 cells by LC/MS and found that claudin 12 had a higher expression level in urate-permeable Caco-2 cells. Uric Acid 63-68 claudin 12 Homo sapiens 120-130
30488476-8 2019 The in vitro study showed that uric acid could upregulate the expression of OCT2 and MATE1 in HEK293 cells and MATE1 in HepaRG cells and increase the intracellular metformin concentration in these two cell lines. Uric Acid 31-40 solute carrier family 47 member 1 Homo sapiens 111-116
30488476-9 2019 These results demonstrated that a high uric acid level promoted urinary metformin excretion and decreased the plasma metformin concentration; the in vivo and in vitro studies provided a possible explanation being that high uric acid could upregulate the expression of renal metformin transporters OCTs and MATE1. Uric Acid 39-48 solute carrier family 47 member 1 Rattus norvegicus 306-311
30488476-9 2019 These results demonstrated that a high uric acid level promoted urinary metformin excretion and decreased the plasma metformin concentration; the in vivo and in vitro studies provided a possible explanation being that high uric acid could upregulate the expression of renal metformin transporters OCTs and MATE1. Uric Acid 223-232 solute carrier family 47 member 1 Rattus norvegicus 306-311
31502429-1 2019 BACKGROUND/AIMS: Glucose transporter 9 (GLUT9/SLC2A9) is the major regulator of uric acid homeostasis in humans. Uric Acid 80-89 solute carrier family 2 member 9 Homo sapiens 40-45
31502429-1 2019 BACKGROUND/AIMS: Glucose transporter 9 (GLUT9/SLC2A9) is the major regulator of uric acid homeostasis in humans. Uric Acid 80-89 solute carrier family 2 member 9 Homo sapiens 46-52
31502429-7 2019 RESULTS: Functional experiments unveiled that uric acid transport mediated by GLUT9a but not GLUT9b is chloride-dependent: Replacing chloride by different anions resulted in a 3.43+-0.63-fold increase of GLUT9a- but not GLUT9b-mediated currents. Uric Acid 46-55 solute carrier family 2 member 9 Homo sapiens 78-83
30591286-11 2019 Recent demonstration that cholesterol crystals trigger the NLRP3 (nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3) inflammasome and the release of inflammatory cytokines that also drive uric acid crystal-induced inflammation indicates that the multiple actions of colchicine that make it effective in gout may be relevant to preventing inflammation and limiting inflammatory injury in atherosclerosis. Uric Acid 234-243 NLR family pyrin domain containing 3 Homo sapiens 59-64
31871416-5 2019 E-selectin and ICAM-1 correlated (p < 0.05) with BMI Z-score (r = 0.24, r = 0.29), ICAM-1 also with uric acid (r = 0.35), HDL-cholesterol (r = -0.28), platelet-to-lymphocyte ratio (r = 0.26), and systolic and mean blood pressure variability (r = 0.24, r = 0.24); in boys ICAM-1 correlated with mean platelet volume (r = 0.29). Uric Acid 103-112 selectin E Homo sapiens 0-10
31871416-5 2019 E-selectin and ICAM-1 correlated (p < 0.05) with BMI Z-score (r = 0.24, r = 0.29), ICAM-1 also with uric acid (r = 0.35), HDL-cholesterol (r = -0.28), platelet-to-lymphocyte ratio (r = 0.26), and systolic and mean blood pressure variability (r = 0.24, r = 0.24); in boys ICAM-1 correlated with mean platelet volume (r = 0.29). Uric Acid 103-112 intercellular adhesion molecule 1 Homo sapiens 86-92
31871416-5 2019 E-selectin and ICAM-1 correlated (p < 0.05) with BMI Z-score (r = 0.24, r = 0.29), ICAM-1 also with uric acid (r = 0.35), HDL-cholesterol (r = -0.28), platelet-to-lymphocyte ratio (r = 0.26), and systolic and mean blood pressure variability (r = 0.24, r = 0.24); in boys ICAM-1 correlated with mean platelet volume (r = 0.29). Uric Acid 103-112 intercellular adhesion molecule 1 Homo sapiens 86-92
31871416-6 2019 In multivariate analysis the only significant predictor of E-selectin was mean arterial pressure during 24 hours (beta = 0.329, 95% CI: 0.012-0.646) and of ICAM-1 - uric acid (beta = 0.430, 95% CI: 0.040-0.819). Uric Acid 165-174 intercellular adhesion molecule 1 Homo sapiens 156-162
29792136-8 2019 Attenuation of glomerular hyperfiltration and improvement in a number of surrogate risk factors, including associated reduction in systemic blood pressure, body weight, and serum uric acid levels may represent plausible mechanistic explanations for the cardio-renal protection offered by SGLT-2 inhibitors. Uric Acid 179-188 solute carrier family 5 member 2 Homo sapiens 288-294
30095142-5 2019 The 26 selected articles point towards an association between higher levels of uric acid, homocysteine, and interleukin 6 with lower cognitive performance in executive, attentional, and memory domains. Uric Acid 79-88 interleukin 6 Homo sapiens 108-121
31235151-0 2019 Relationship between insulin resistance, metabolic syndrome components and serum uric acid. Uric Acid 81-90 insulin Homo sapiens 21-28
31235151-3 2019 Some research have reported relation between metabolic syndrome mediated by insulin resistance with increasing of serum uric acid level. Uric Acid 120-129 insulin Homo sapiens 76-83
31235151-4 2019 OBJECTIVE: Assess relationship between insulin resistance and metabolic syndrome components with the level of serum uric acid. Uric Acid 116-125 insulin Homo sapiens 39-46
31235151-10 2019 CONCLUSION: Insulin resistance is related to the incidence of MetS and in both of these circumstances an independent tendency is found to increase uric acid levels. Uric Acid 147-156 insulin Homo sapiens 12-19
29936631-2 2019 Xanthine oxidoreductase (XOR) plays a pivotal role in producing both uric acid and ROS. Uric Acid 69-78 xanthine dehydrogenase Homo sapiens 0-23
29936631-2 2019 Xanthine oxidoreductase (XOR) plays a pivotal role in producing both uric acid and ROS. Uric Acid 69-78 xanthine dehydrogenase Homo sapiens 25-28
30499423-0 2019 Sex-Specific Association Between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study. Uric Acid 39-48 glutamic--pyruvic transaminase Homo sapiens 62-86
30499423-1 2019 AIM: The study was conducted in order to examine the sex-specific association of serum uric acid (SUA) levels with elevated serum alanine aminotransferase (ALT) in a Taiwanese military cohort. Uric Acid 87-96 glutamic--pyruvic transaminase Homo sapiens 130-154
29926959-9 2019 RESULTS: Uric acid to creatinine ratio was significantly correlated with Crohn"s disease activity index (rho = 0.184, P = 0.002) and Harvey Bradshaw index (rho = 0.154, P = 0.010) and C-reactive protein (rho = 0.591, P < 0.001) in CD group. Uric Acid 9-18 C-reactive protein Homo sapiens 184-202
31430745-5 2019 Klotho fractional enrichment across the kidney was inversely related to plasma sodium (r = 0.43, p = 0.045) and acid uric acid levels (r = 0.38, p = 0.084) and directly, to renal oxygen extraction (r = 0.56, p = 0.006). Uric Acid 117-126 klotho Homo sapiens 0-6
30740729-2 2019 UA excess, causing renal failure, is commonly decreased by xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, yielding a xanthine and hypoxanthine increase. Uric Acid 0-2 xanthine dehydrogenase Homo sapiens 59-82
30740729-2 2019 UA excess, causing renal failure, is commonly decreased by xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, yielding a xanthine and hypoxanthine increase. Uric Acid 0-2 xanthine dehydrogenase Homo sapiens 84-87
30740729-4 2019 Inhibition of purine nucleoside phosphorylase (PNP) represents a different strategy for lowering urate. Uric Acid 97-102 purine nucleoside phosphorylase Homo sapiens 14-45
30740729-4 2019 Inhibition of purine nucleoside phosphorylase (PNP) represents a different strategy for lowering urate. Uric Acid 97-102 purine nucleoside phosphorylase Homo sapiens 47-50
30740729-5 2019 PNP catalyzes the cleavage of purine ribo- and d-ribo-nucleosides into ribose/deoxyribose phosphate and free bases, starting catabolism to uric acid. Uric Acid 139-148 purine nucleoside phosphorylase Homo sapiens 0-3
30265377-3 2019 Here we demonstrated that reprogramming COX-2, 5-LOX, and CYP4A-mediated AA metabolism in macrophages by salidroside (Sal) ameliorates monosodium urate (MSU) crystal-induced inflammation. Uric Acid 135-151 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45
30265377-3 2019 Here we demonstrated that reprogramming COX-2, 5-LOX, and CYP4A-mediated AA metabolism in macrophages by salidroside (Sal) ameliorates monosodium urate (MSU) crystal-induced inflammation. Uric Acid 153-156 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45
29457379-8 2018 Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings. Uric Acid 14-19 interleukin 6 Homo sapiens 40-44
31574506-8 2019 Patients with high Gd-IgA1 levels had significantly higher levels of uric acid (UA) and IgA. Uric Acid 69-78 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26
31574506-8 2019 Patients with high Gd-IgA1 levels had significantly higher levels of uric acid (UA) and IgA. Uric Acid 80-82 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26
31574506-15 2019 The level of plasma Gd-IgA1 positively correlated with levels of UA, total IgA levels, and complement activation products. Uric Acid 65-67 immunoglobulin heavy constant alpha 1 Homo sapiens 23-27
31860850-10 2019 In the 1st group, correlation between UA and BP was moderate for SBP - r = +0,34 and weak for DBP - r = +0,29; in the 2nd group: SBP - r = +0,49 and r = +0,35 for DBP. Uric Acid 38-40 selenium binding protein 1 Homo sapiens 65-68
31860850-10 2019 In the 1st group, correlation between UA and BP was moderate for SBP - r = +0,34 and weak for DBP - r = +0,29; in the 2nd group: SBP - r = +0,49 and r = +0,35 for DBP. Uric Acid 38-40 D-box binding PAR bZIP transcription factor Homo sapiens 94-97
31860850-10 2019 In the 1st group, correlation between UA and BP was moderate for SBP - r = +0,34 and weak for DBP - r = +0,29; in the 2nd group: SBP - r = +0,49 and r = +0,35 for DBP. Uric Acid 38-40 D-box binding PAR bZIP transcription factor Homo sapiens 163-166
30455459-4 2019 This concept was mechanistically substantiated in acute monosodium-urate-crystal-induced inflammation, where the pro-resolution function of DEL-1 was attributed to effective apoptotic neutrophil clearance (efferocytosis). Uric Acid 56-72 EGF-like repeats and discoidin I-like domains 3 Mus musculus 140-145
29457379-8 2018 Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings. Uric Acid 14-19 C-X-C motif chemokine ligand 8 Homo sapiens 83-87
29457379-8 2018 Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings. Uric Acid 14-19 microRNA 155 Homo sapiens 129-136
29457379-9 2018 CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout. Uric Acid 169-185 interleukin 6 Homo sapiens 251-255
29457379-9 2018 CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout. Uric Acid 169-185 C-X-C motif chemokine ligand 8 Homo sapiens 260-264
29457379-9 2018 CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout. Uric Acid 169-185 microRNA 155 Homo sapiens 313-320
30302962-7 2018 The risk of incident MetS increased as the uric acid category advanced in individuals with lower or higher serum albumin categories with hazard ratios (HRs) of 1.386 (95% confidence interval [CI], 1.236 to 1.554) or 1.314 (95% CI, 1.167 to 1.480). Uric Acid 43-52 albumin Homo sapiens 107-120
30410032-7 2018 From the low to high GGT quartiles, the incidence of each CRF and clustered risk factors increased after adjusting for age, uric acid (UA), ethnicity, drinking, and all other risk factors. Uric Acid 124-133 gamma-glutamyltransferase light chain family member 3 Homo sapiens 21-24
30132721-2 2018 Soy vinegar extracts (SVEs), which contain free isoflavones, ubiquinones, gamma-aminobutyric acid, gallic acid, and acetic acid, reduced the level of uric acid (UA) by decreasing UA production through xanthine oxidase inhibition and increasing UA excretion through uricase activity in hyperuricemic mice (P < .05). Uric Acid 150-159 xanthine dehydrogenase Mus musculus 201-217
30105595-0 2018 SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. Uric Acid 24-29 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-6
30105595-0 2018 SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. Uric Acid 24-29 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 8-13
30105595-4 2018 Mice carrying a deletion of GLUT9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation. Uric Acid 123-132 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 28-33
30105595-12 2018 Overall, these results indicate that GLUT9 is a crucial player in renal handling of urate in vivo and a putative target for uricosuric drugs. Uric Acid 84-89 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 37-42
29088986-11 2018 UA level is comparably dominant in saliva and in plasma according to DPPH, but lower in plasma according to FRAP. Uric Acid 0-2 mechanistic target of rapamycin kinase Homo sapiens 108-112
30581534-0 2018 Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression. Uric Acid 0-9 NFE2 like bZIP transcription factor 2 Rattus norvegicus 103-107
30581534-0 2018 Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression. Uric Acid 0-9 neurotrophin 3 Rattus norvegicus 123-142
30581534-1 2018 The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats. Uric Acid 49-58 NFE2 like bZIP transcription factor 2 Rattus norvegicus 111-154
30581534-1 2018 The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats. Uric Acid 49-58 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-160
30581534-1 2018 The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats. Uric Acid 60-62 NFE2 like bZIP transcription factor 2 Rattus norvegicus 111-154
30581534-1 2018 The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection via activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and regulating neurotrophic factors in the cerebral cortices after transient focal cerebral ischemia/reperfusion (FCI/R) in rats. Uric Acid 60-62 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-160
30581534-10 2018 Interestingly, the aforementioned effects of UA were markedly inhibited by administration of brusatol, an inhibitor of Nrf2. Uric Acid 45-47 NFE2 like bZIP transcription factor 2 Rattus norvegicus 119-123
30581534-11 2018 Taken together, the antioxidant and neuroprotective effects afforded by UA treatment involved the modulation of Nrf2-mediated oxidative stress and regulation of BDNF and NGF expression levels. Uric Acid 72-74 NFE2 like bZIP transcription factor 2 Rattus norvegicus 112-116
30581534-11 2018 Taken together, the antioxidant and neuroprotective effects afforded by UA treatment involved the modulation of Nrf2-mediated oxidative stress and regulation of BDNF and NGF expression levels. Uric Acid 72-74 brain-derived neurotrophic factor Rattus norvegicus 161-165
30124855-0 2018 A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Uric Acid 61-66 hepatocyte nuclear factor 4 alpha Homo sapiens 100-105
30124855-0 2018 A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Uric Acid 61-66 PDZ domain containing 1 Homo sapiens 116-121
30124855-11 2018 Computational prediction of increased motif strength, together with our functional assays, suggests that the urate-increasing T allele of rs1967017 strengthens a binding site for the transcription factor HNF4A. Uric Acid 109-114 hepatocyte nuclear factor 4 alpha Homo sapiens 204-209
30124855-12 2018 Our and other data predict that the urate-raising T allele of rs1967017 enhances HNF4A binding to the PDZK1 promoter, thereby increasing PDZK1 expression. Uric Acid 36-41 hepatocyte nuclear factor 4 alpha Homo sapiens 81-86
30124855-12 2018 Our and other data predict that the urate-raising T allele of rs1967017 enhances HNF4A binding to the PDZK1 promoter, thereby increasing PDZK1 expression. Uric Acid 36-41 PDZ domain containing 1 Homo sapiens 102-107
30124855-12 2018 Our and other data predict that the urate-raising T allele of rs1967017 enhances HNF4A binding to the PDZK1 promoter, thereby increasing PDZK1 expression. Uric Acid 36-41 PDZ domain containing 1 Homo sapiens 137-142
30124855-13 2018 As PDZK1 is a scaffold protein for many ion channel transporters, increased expression can be predicted to increase activity of urate transporters and alter excretion of urate. Uric Acid 128-133 PDZ domain containing 1 Homo sapiens 3-8
30544373-6 2018 As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-alpha increased significantly as the UA level increased. Uric Acid 7-9 superoxide dismutase 1 Homo sapiens 60-63
30544373-6 2018 As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-alpha increased significantly as the UA level increased. Uric Acid 149-151 interleukin 6 Homo sapiens 99-103
30544373-6 2018 As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-alpha increased significantly as the UA level increased. Uric Acid 149-151 tumor necrosis factor Homo sapiens 108-117
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 153-157
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 tumor necrosis factor Homo sapiens 162-171
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 tumor necrosis factor Homo sapiens 298-307
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 tumor necrosis factor Homo sapiens 298-307
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 superoxide dismutase 1 Homo sapiens 378-381
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293
30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 tumor necrosis factor Homo sapiens 298-307
30068899-0 2018 Unexpected high plasma xanthine oxidoreductase activity in female subjects with low levels of uric acid. Uric Acid 94-103 xanthine dehydrogenase Homo sapiens 23-46
30068899-2 2018 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Uric Acid 75-84 xanthine dehydrogenase Homo sapiens 0-23
30068899-2 2018 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Uric Acid 75-84 xanthine dehydrogenase Homo sapiens 25-28
30068899-4 2018 We measured plasma XOR activity by a sensitive and accurate assay using a combination of liquid chromatography and triple quadrupole mass spectrometry in subjects with relatively low levels of uric acid (<=4.0 mg/dL) who were recruited from 627 subjects (male/female: 292/335) in the Tanno-Sobetsu Study, a population-based cohort. Uric Acid 193-202 xanthine dehydrogenase Homo sapiens 19-22
30068899-7 2018 In 12 (17.9%) of the 67 female subjects with uric acid <=4.0 mg/dL, plasma XOR activities were above the upper quartile value of the 335 female subjects. Uric Acid 45-54 xanthine dehydrogenase Homo sapiens 78-81
30068899-8 2018 Eleven of the 12 female subjects with high plasma XOR activity and a low uric acid level had liver dysfunction and/or insulin resistance. Uric Acid 73-82 insulin Homo sapiens 118-125
30068899-9 2018 In conclusion, unexpected high plasma XOR activities were found in some female subjects with relatively low levels of uric acid. Uric Acid 118-127 xanthine dehydrogenase Homo sapiens 38-41
30486413-5 2018 Meanwhile, activities of hepatic ADA and XOD were markedly augmented by adenine, and the expression of URAT1 was promoted, which was conducive to the reabsorption of urate. Uric Acid 166-171 adenosine deaminase Mus musculus 33-36
30486413-5 2018 Meanwhile, activities of hepatic ADA and XOD were markedly augmented by adenine, and the expression of URAT1 was promoted, which was conducive to the reabsorption of urate. Uric Acid 166-171 xanthine dehydrogenase Mus musculus 41-44
30486413-5 2018 Meanwhile, activities of hepatic ADA and XOD were markedly augmented by adenine, and the expression of URAT1 was promoted, which was conducive to the reabsorption of urate. Uric Acid 166-171 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 103-108
30469427-6 2018 UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. Uric Acid 0-2 insulin Homo sapiens 119-126
30410032-7 2018 From the low to high GGT quartiles, the incidence of each CRF and clustered risk factors increased after adjusting for age, uric acid (UA), ethnicity, drinking, and all other risk factors. Uric Acid 135-137 gamma-glutamyltransferase light chain family member 3 Homo sapiens 21-24
30293967-3 2018 In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts. Uric Acid 99-108 transforming growth factor beta 1 Homo sapiens 190-222
30395654-10 2018 There was a significant decreasing trend of serum uric acid levels with the progression of fibrotic stages among male patients (6.21 +- 1.03 mg/dL 5.82 +- 1.16 mg/dL and 5.44 +- 1.28 mg/dL in stages F0-2, F3, and F4, respectively, trend P = 0.01). Uric Acid 50-59 coagulation factor II, thrombin Homo sapiens 199-203
30293967-3 2018 In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts. Uric Acid 99-108 transforming growth factor beta 1 Homo sapiens 224-233
30293967-3 2018 In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts. Uric Acid 99-108 epidermal growth factor receptor Homo sapiens 236-268
30293967-3 2018 In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts. Uric Acid 99-108 epidermal growth factor receptor Homo sapiens 270-274
30173364-6 2018 RESULTS: Using clinical-metabolomics models, we identified associations of decreased eGFR with body mass index (BMI), uric acid and C10:2 levels; albuminuria was associated to years of T2D duration, A1C, uric acid, creatinine, protein intake and serum C0, C10:2 and urinary C12:1 levels. Uric Acid 118-127 epidermal growth factor receptor Homo sapiens 85-89
29626256-11 2018 For UA stones, median VMR was 0.95-0.99 and DER 1.00-1.02. Uric Acid 4-6 derlin 1 Homo sapiens 44-49
30173364-6 2018 RESULTS: Using clinical-metabolomics models, we identified associations of decreased eGFR with body mass index (BMI), uric acid and C10:2 levels; albuminuria was associated to years of T2D duration, A1C, uric acid, creatinine, protein intake and serum C0, C10:2 and urinary C12:1 levels. Uric Acid 204-213 epidermal growth factor receptor Homo sapiens 85-89
29619870-7 2018 Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26-6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine. Uric Acid 56-65 epidermal growth factor receptor Homo sapiens 20-24
30175447-3 2018 The IL-1beta response is mediated via inflammasome activation by the damage-associated molecular pattern (DAMP), uric acid. Uric Acid 113-122 interleukin 1 alpha Homo sapiens 4-12
30257382-9 2018 The data from the present study revealed that testosterone exposure in the late gestation causes elevated cardiac Eng that is accompanied by increased UA production and defective G6PD-dependent anti-oxidant defenses. Uric Acid 151-153 endoglin Rattus norvegicus 114-117
30257382-10 2018 Besides, the findings also suggest that the inhibitory effect of SAc or Flu on endoglin attenuates UA production and enhances the G6PD-dependent anti-oxidant barrier, thereby implying that endoglin may be a potentially novel therapeutic intervention for cardiac dysfunction particularly in pregnancy. Uric Acid 99-101 endoglin Rattus norvegicus 79-87
30257382-10 2018 Besides, the findings also suggest that the inhibitory effect of SAc or Flu on endoglin attenuates UA production and enhances the G6PD-dependent anti-oxidant barrier, thereby implying that endoglin may be a potentially novel therapeutic intervention for cardiac dysfunction particularly in pregnancy. Uric Acid 99-101 endoglin Rattus norvegicus 189-197
30001502-9 2018 The findings imply that VPA would provide protection against the development of cardiometabolic disorder via inhibition of the ADA/XO/UA-mediated pathway. Uric Acid 134-136 adenosine deaminase Rattus norvegicus 127-130
30257327-0 2018 CXCR1/CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy. Uric Acid 67-76 chemokine (C-X-C motif) receptor 1 Mus musculus 0-5
30185927-8 2018 Using Western blot analysis, we observed that uric acid reduced endothelial nitric oxide synthase phosphorylation during hypoxic conditions. Uric Acid 46-55 nitric oxide synthase 3 Homo sapiens 64-97
28764560-8 2018 However, collectrin concentrations were negatively correlated with systolic blood pressure (r = -0.284, p = .011) and diastolic blood pressure (r = -0.275, p = .014) as well as with maternal serum urea (r = -0.269, p = .017) and uric acid (r = -0.219, p = .049) concentrations. Uric Acid 229-238 collectrin, amino acid transport regulator Homo sapiens 9-19
30388753-3 2018 (2) Methods: We prepared the MeOH extracts of 107 different crude drugs, and screened their inhibitory effects on URAT1 by measuring the uptake of uric acid by HEK293/PDZK1 cells transiently transfected with URAT1. Uric Acid 147-156 solute carrier family 22 member 12 Homo sapiens 114-119
30388753-3 2018 (2) Methods: We prepared the MeOH extracts of 107 different crude drugs, and screened their inhibitory effects on URAT1 by measuring the uptake of uric acid by HEK293/PDZK1 cells transiently transfected with URAT1. Uric Acid 147-156 PDZ domain containing 1 Homo sapiens 167-172
30388753-4 2018 (3) Results: We found that the extract of the dried mature fruit of Cnidium monnieri inhibited urate uptake via URAT1. Uric Acid 95-100 solute carrier family 22 member 12 Homo sapiens 112-117
29619870-7 2018 Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26-6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine. Uric Acid 56-65 CD59 molecule (CD59 blood group) Homo sapiens 113-118
29619870-7 2018 Pooled estimate for eGFR was in favor of lowering serum uric acid therapy with a mean difference (MD) of 3.88 ml/min/1.73 m2, 95% CI 1.26-6.49 ml/min/1.73 m2, p = .004 and this was consistent with results for serum creatinine. Uric Acid 56-65 CD59 molecule (CD59 blood group) Homo sapiens 146-151
29958959-13 2018 In vivo, LEP treatment significantly reduced the effects of CCl4 intoxication on serum liver biomarkers (AST, ALT, LDH, and GGT) and the effect of cisplatin on serum renal biomarkers (urea, blood urea nitrogen, creatinine, and uric acid). Uric Acid 227-236 leptin Mus musculus 9-12
30380730-4 2018 Materials and Methods: The relationship between the initial GGT and UA levels and invasive mechanical ventilation (IMV) and noninvasive mechanical ventilation (NIV) support, inotropic drug need, acute renal kidney injury (AKI), continuous renal replacement therapy (CRRT), presence of sepsis, mortality, and hospitalization period were investigated retrospectively. Uric Acid 68-70 gamma-glutamyltransferase 1 Homo sapiens 60-63
29492591-6 2018 Notably, those with uric acid stones had worse eGFR than those with non-uric acid stones. Uric Acid 20-29 epidermal growth factor receptor Homo sapiens 47-51
30666040-11 2018 Decrease in serum uric acid levels reduced GIS, AIS, MCP-1 expression and macrophages M1/M2 ratio (p<0.05). Uric Acid 18-27 mast cell protease 1 Mus musculus 53-58
29958959-13 2018 In vivo, LEP treatment significantly reduced the effects of CCl4 intoxication on serum liver biomarkers (AST, ALT, LDH, and GGT) and the effect of cisplatin on serum renal biomarkers (urea, blood urea nitrogen, creatinine, and uric acid). Uric Acid 227-236 chemokine (C-C motif) ligand 4 Mus musculus 60-64
30356327-2 2018 Uric acid has been shown to associate with vascular calcification and with carotid intima-media thickness (CIMT) and to suppress the 1 alpha-hydroxylase enzyme leading to lower 1,25-dihydroxyvitamin D (1,25(OH)2D) and higher intact parathyroid hormone (iPTH) levels. Uric Acid 0-9 CIMT Homo sapiens 107-111
30356327-3 2018 We hypothesized that lowering serum uric acid would reduce CIMT, calcification propensity, and circulating markers of CKD-MBD in CKD. Uric Acid 36-45 CIMT Homo sapiens 59-63
29894955-6 2018 Hence, a fluorescence quenching method for the determination of uric acid was established in the concentration range from 5.0 to 400 muM with the detection limit (3sigma/S) of 2.26 muM. Uric Acid 64-73 latexin Homo sapiens 133-136
30425593-4 2018 Pegloticase is a recombinant, pegylated uricase used in the treatment of gout patients who fail conventional urate-lowering therapy. Uric Acid 109-114 urate oxidase (pseudogene) Homo sapiens 40-47
30242335-0 2018 Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial. Uric Acid 72-81 interleukin 1 beta Homo sapiens 16-33
30315176-7 2018 In SLC2A9, mapping of rare variants of large effects onto the predicted protein structure reveals new residues that may affect urate binding. Uric Acid 127-132 solute carrier family 2 member 9 Homo sapiens 3-9
30315176-8 2018 These findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout. Uric Acid 75-80 solute carrier family 22 member 12 Homo sapiens 117-125
30315176-8 2018 These findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout. Uric Acid 75-80 solute carrier family 2 member 9 Homo sapiens 130-136
30315176-8 2018 These findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout. Uric Acid 156-161 solute carrier family 22 member 12 Homo sapiens 117-125
30315176-8 2018 These findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout. Uric Acid 156-161 solute carrier family 2 member 9 Homo sapiens 130-136
29894961-5 2018 Under optimized conditions, the fluorescence intensities of Tb-dtpa-bdap solution towards different uric acid concentrations show a linear response in the range from 1.00 x 10-5 mol L-1 to 5.00 x 10-5 mol L-1 with a linear correlation coefficient (R2) of 0.9877. Uric Acid 100-109 L1 cell adhesion molecule Homo sapiens 182-185
29894961-5 2018 Under optimized conditions, the fluorescence intensities of Tb-dtpa-bdap solution towards different uric acid concentrations show a linear response in the range from 1.00 x 10-5 mol L-1 to 5.00 x 10-5 mol L-1 with a linear correlation coefficient (R2) of 0.9877. Uric Acid 100-109 L1 cell adhesion molecule Homo sapiens 205-208
29894961-6 2018 And the obtained limit of detection (LOD) is about 5.80 x 10-6 mol L-1, which is lower than the level of uric acid in actual urine. Uric Acid 105-114 L1 cell adhesion molecule Homo sapiens 67-70
30352070-6 2018 Urate GCM levels (median = 620 ng/g dry wt., range = 0.74-7200 ng/g dry wt., n = 216) significantly increased within 2 hr of the acute handling stressor (p = 0.032, n = 11 condors, one-tailed paired t-test), while feather section CORT concentrations (median = 18 pg/mm, range = 6.3-68 ng/g, n = 37) also varied widely within and between feathers. Uric Acid 0-5 cortistatin Homo sapiens 230-234
30321229-5 2018 Next, to investigate the genetic basis that controls uric acid accumulation in S. ricini larvae, we isolated and characterized the S. ricini homolog of mammalian biogenesis of lysosome-related organelles complex 1, subunit 2 (BLOS2), which is known to play a crucial role in urate granule biosynthesis. Uric Acid 53-62 biogenesis of lysosomal organelles complex 1 subunit 2 Homo sapiens 162-224
29894955-6 2018 Hence, a fluorescence quenching method for the determination of uric acid was established in the concentration range from 5.0 to 400 muM with the detection limit (3sigma/S) of 2.26 muM. Uric Acid 64-73 latexin Homo sapiens 181-184
30641534-0 2018 Articular cartilage of knee and first MTP joint are the preferred sites to find double contour sign as an evidence of urate crystal deposition in asymptomatic hyperuricemic individuals. Uric Acid 118-123 metallothionein 1B Homo sapiens 38-41
29978510-5 2018 In addition to modified chemokines, a GAG-binding peptide consisting of the 30 COOH-terminal residues of CXCL9, that is CXCL9(74-103), inhibited CXCL8- and monosodium urate crystal-induced neutrophil migration. Uric Acid 156-172 melanoma antigen Mus musculus 38-41
29804160-10 2018 The NLRP3 inflammasome activator monosodium urate partly abrogated the effect of melatonin on the expression of osteoblastogenic markers, including Runx2 and OCN. Uric Acid 33-49 NLR family, pyrin domain containing 3 Mus musculus 4-9
29804160-10 2018 The NLRP3 inflammasome activator monosodium urate partly abrogated the effect of melatonin on the expression of osteoblastogenic markers, including Runx2 and OCN. Uric Acid 33-49 runt related transcription factor 2 Mus musculus 148-153
29804160-10 2018 The NLRP3 inflammasome activator monosodium urate partly abrogated the effect of melatonin on the expression of osteoblastogenic markers, including Runx2 and OCN. Uric Acid 33-49 bone gamma-carboxyglutamate protein 2 Mus musculus 158-161
29906649-1 2018 Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism. Uric Acid 64-73 xanthine dehydrogenase Homo sapiens 0-23
30118829-8 2018 Conversely, uric acid significantly decreased the levels of HOCl, probably because of the competition with chloride by the catalysis of myeloperoxidase. Uric Acid 12-21 myeloperoxidase Homo sapiens 136-151
29978510-5 2018 In addition to modified chemokines, a GAG-binding peptide consisting of the 30 COOH-terminal residues of CXCL9, that is CXCL9(74-103), inhibited CXCL8- and monosodium urate crystal-induced neutrophil migration. Uric Acid 156-172 chemokine (C-X-C motif) ligand 9 Mus musculus 105-110
29978510-5 2018 In addition to modified chemokines, a GAG-binding peptide consisting of the 30 COOH-terminal residues of CXCL9, that is CXCL9(74-103), inhibited CXCL8- and monosodium urate crystal-induced neutrophil migration. Uric Acid 156-172 chemokine (C-X-C motif) ligand 9 Mus musculus 120-125
30350810-5 2018 SLC2A9 is a renal urate transporter that controls renal uric acid excretion and genetic variants in SLC2A9 are associated with the risk of gout in several populations. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 0-6
31949578-7 2018 Compared with the control (normal lipid) group, the dyslipidemia group with IgAN had higher blood uric acid, serum creatinine, blood urea nitrogen and urinary protein quantity, higher proportions of mesangial cell proliferation and renal tubular atrophy/interstitial fibrosis (IFTA), and a lower estimated glomerular filtration rate and serum albumin. Uric Acid 98-107 IGAN1 Homo sapiens 76-80
30334984-6 2018 The frequency of urate crystal deposition detected by US at MTP1, knee, and ankle joints regions was 56.7%, 63.3%, and 51.7%, respectively. Uric Acid 17-22 solute carrier family 40 member 1 Homo sapiens 60-64
29939348-5 2018 We measured plasma vitamin C in 9234 individuals and genotyped for the SLC2A9 rs7442295 urate variant in 102 345 individuals. Uric Acid 88-93 solute carrier family 2 member 9 Homo sapiens 71-77
29928993-0 2018 Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice. Uric Acid 0-5 superoxide dismutase 1, soluble Mus musculus 97-101
29928993-6 2018 Our results demonstrate a significant protective effect of urate against motor neuron injury evoked by mutant astrocytes derived from SOD1G93A mice or hydrogen peroxide induced oxidative stress. Uric Acid 59-64 superoxide dismutase 1, soluble Mus musculus 134-138
30104401-3 2018 Using data from The Cancer Genome Atlas (TCGA), we analysed the expression levels of xanthine dehydrogenase (XDH) and adenine phosphoribosyltransferase (APRT), two key enzymes in UA production and the purine salvage pathway, respectively. Uric Acid 179-181 xanthine dehydrogenase Homo sapiens 85-107
30320253-7 2018 The biosensor showed a highly selective H2O2 signal with current sensitivity and detection limit values 0.1303 muA muM-1 and 990 nM, respectively, with tolerable interference from the common biochemicals like dissolved oxygen, cysteine, ascorbic acid, glucose, xanthine, hypoxanthine, uric acid, and hydrazine. Uric Acid 285-294 PWWP domain containing 3A, DNA repair factor Homo sapiens 115-120
30337978-6 2018 A student"s t-test was used to determine if there was an association between Hba1 and uric acid levels. Uric Acid 86-95 hemoglobin subunit alpha 1 Homo sapiens 77-81
30104401-3 2018 Using data from The Cancer Genome Atlas (TCGA), we analysed the expression levels of xanthine dehydrogenase (XDH) and adenine phosphoribosyltransferase (APRT), two key enzymes in UA production and the purine salvage pathway, respectively. Uric Acid 179-181 xanthine dehydrogenase Homo sapiens 109-112
30104401-3 2018 Using data from The Cancer Genome Atlas (TCGA), we analysed the expression levels of xanthine dehydrogenase (XDH) and adenine phosphoribosyltransferase (APRT), two key enzymes in UA production and the purine salvage pathway, respectively. Uric Acid 179-181 adenine phosphoribosyltransferase Homo sapiens 118-151
30104401-3 2018 Using data from The Cancer Genome Atlas (TCGA), we analysed the expression levels of xanthine dehydrogenase (XDH) and adenine phosphoribosyltransferase (APRT), two key enzymes in UA production and the purine salvage pathway, respectively. Uric Acid 179-181 adenine phosphoribosyltransferase Homo sapiens 153-157
30166062-0 2018 High-mobility group box 1 is responsible for monosodium urate crystal-induced inflammation in human U937 macrophages. Uric Acid 45-61 high mobility group box 1 Homo sapiens 0-25
30166062-2 2018 We performed this study to investigate the role of HMGB1 in the pathogenesis of uric acid-induced inflammation in human U937 macrophages. Uric Acid 80-89 high mobility group box 1 Homo sapiens 51-56
30166062-8 2018 Stimulation of U937 cells with MSU crystals induced translocation of HMGB1 from the nucleus to the cytoplasm and its extracellular release. Uric Acid 31-34 high mobility group box 1 Homo sapiens 69-74
30166062-11 2018 In conclusion, HMGB1, regulated by the enzymatic activity of caspase-1, is a crucial mediator in uric acid-induced inflammation. Uric Acid 97-106 high mobility group box 1 Homo sapiens 15-20
30166062-11 2018 In conclusion, HMGB1, regulated by the enzymatic activity of caspase-1, is a crucial mediator in uric acid-induced inflammation. Uric Acid 97-106 caspase 1 Homo sapiens 61-70
30181573-5 2018 Genome-wide significant associations with serum urate and gout were identified for known loci at SLC2A9 and ABCG2, but not for novel loci. Uric Acid 48-53 solute carrier family 2 member 9 Homo sapiens 97-103
30140810-4 2018 Using dual-enzyme inorganic hybrid nanoflowers in the muPAD as nanobiocatalysts, which preserve the activity and enhance the stability of the enzymes, based on the H2O2-mediated catalytic oxidizing chromogenic reaction produced by glucose/uric acid, the developed multiplex paper-based nanobiocatalytic system is demonstrated to enable simultaneous and sensitive detection of glucose and uric acid with a detection limit of 60 and 25 muM, respectively. Uric Acid 239-248 latexin Homo sapiens 434-437
30140810-4 2018 Using dual-enzyme inorganic hybrid nanoflowers in the muPAD as nanobiocatalysts, which preserve the activity and enhance the stability of the enzymes, based on the H2O2-mediated catalytic oxidizing chromogenic reaction produced by glucose/uric acid, the developed multiplex paper-based nanobiocatalytic system is demonstrated to enable simultaneous and sensitive detection of glucose and uric acid with a detection limit of 60 and 25 muM, respectively. Uric Acid 388-397 latexin Homo sapiens 434-437
30189890-0 2018 Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Uric Acid 27-43 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 135-139
29932924-0 2018 The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway. Uric Acid 12-21 notch receptor 1 Rattus norvegicus 75-80
29932924-2 2018 Although Notch signaling was reported to be affected in the presence of high concentrations of uric acid or glucose, the underlying mechanisms of hyperuricemia through the Notch signaling pathway to promote the development of diabetic retinopathy remain unknown. Uric Acid 95-104 notch receptor 1 Rattus norvegicus 9-14
29932924-11 2018 Notch signaling pathway activity was also increased most significantly in high uric acid plus high glucose group. Uric Acid 79-88 notch receptor 1 Rattus norvegicus 0-5
29932924-12 2018 After Notch 1 siRNA transfection in high glucose and high glucose plus uric acid group, the activity of Notch signaling pathway was successfully down-regulated. Uric Acid 71-80 notch receptor 1 Rattus norvegicus 6-13
29932924-12 2018 After Notch 1 siRNA transfection in high glucose and high glucose plus uric acid group, the activity of Notch signaling pathway was successfully down-regulated. Uric Acid 71-80 notch receptor 1 Rattus norvegicus 6-11
29932924-14 2018 CONCLUSION: Our study reported that high uric acid can promote the inflammation of the retina and increase the activity of Notch signaling pathway on the basis of high glucose. Uric Acid 41-50 notch receptor 1 Rattus norvegicus 123-128
29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 192-208 NLR family pyrin domain containing 3 Homo sapiens 28-33
29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 192-208 NLR family pyrin domain containing 3 Homo sapiens 110-115
29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 210-213 NLR family pyrin domain containing 3 Homo sapiens 28-33
29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 210-213 NLR family pyrin domain containing 3 Homo sapiens 110-115
30189835-0 2018 Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children. Uric Acid 75-84 solute carrier family 2 member 9 Homo sapiens 25-31
30189835-0 2018 Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children. Uric Acid 75-84 solute carrier family 22 member 12 Homo sapiens 42-50
30181573-5 2018 Genome-wide significant associations with serum urate and gout were identified for known loci at SLC2A9 and ABCG2, but not for novel loci. Uric Acid 48-53 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-113
30181573-9 2018 Known genetic variants in SLC2A9 and ABCG2 were associated with urate and gout in a CKD cohort, with effect sizes for ABCG2 significantly greater in CKD compared to the general population. Uric Acid 64-69 solute carrier family 2 member 9 Homo sapiens 26-32
30181573-9 2018 Known genetic variants in SLC2A9 and ABCG2 were associated with urate and gout in a CKD cohort, with effect sizes for ABCG2 significantly greater in CKD compared to the general population. Uric Acid 64-69 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 37-42
30181573-9 2018 Known genetic variants in SLC2A9 and ABCG2 were associated with urate and gout in a CKD cohort, with effect sizes for ABCG2 significantly greater in CKD compared to the general population. Uric Acid 64-69 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 118-123
29803897-5 2018 Evidence available also suggests an association between elevated UA and traditional cardiovascular risk factors, metabolic syndrome, insulin resistance, obesity, non-alcoholic fatty liver disease and chronic kidney disease. Uric Acid 65-67 insulin Homo sapiens 133-140
29803897-6 2018 Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance and metabolic dysregulation. Uric Acid 91-93 insulin Homo sapiens 370-377
30334413-9 2018 The negative correlation for the hs-CRP and fasting glucose and DIA were found in low hs-CRP (r= -0.619; p less than 0.05 and r= -0.580; p less than 0.05 respectively) and for the hs-CRP and uric acid (r=-0.850; p less than 0.05) in the moderate hs-CRP risk group. Uric Acid 191-200 C-reactive protein Homo sapiens 36-39
30294580-1 2018 Aims: The aim of this study was to correlate serum uric acid (SUA) levels and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (DM). Uric Acid 51-60 CIMT Homo sapiens 110-114
30294580-8 2018 Results: Uric acid levels were positively associated with CIMT (P = 0.001). Uric Acid 9-18 CIMT Homo sapiens 58-62
30334413-9 2018 The negative correlation for the hs-CRP and fasting glucose and DIA were found in low hs-CRP (r= -0.619; p less than 0.05 and r= -0.580; p less than 0.05 respectively) and for the hs-CRP and uric acid (r=-0.850; p less than 0.05) in the moderate hs-CRP risk group. Uric Acid 191-200 C-reactive protein Homo sapiens 89-92
30334413-9 2018 The negative correlation for the hs-CRP and fasting glucose and DIA were found in low hs-CRP (r= -0.619; p less than 0.05 and r= -0.580; p less than 0.05 respectively) and for the hs-CRP and uric acid (r=-0.850; p less than 0.05) in the moderate hs-CRP risk group. Uric Acid 191-200 C-reactive protein Homo sapiens 89-92
30334413-9 2018 The negative correlation for the hs-CRP and fasting glucose and DIA were found in low hs-CRP (r= -0.619; p less than 0.05 and r= -0.580; p less than 0.05 respectively) and for the hs-CRP and uric acid (r=-0.850; p less than 0.05) in the moderate hs-CRP risk group. Uric Acid 191-200 C-reactive protein Homo sapiens 89-92
29916994-6 2018 A positive significant association between uric acid, and office, daytime and night-time SBP, insulin and triglycerides was observed. Uric Acid 43-52 selenium binding protein 1 Homo sapiens 89-92
29916994-6 2018 A positive significant association between uric acid, and office, daytime and night-time SBP, insulin and triglycerides was observed. Uric Acid 43-52 insulin Homo sapiens 94-101
29916994-7 2018 When boys and girls were grouped by sex-specific uric acid tertiles, a progressive increment was observed in BMI, BMI z-score and waist circumference as well as fasting insulin and HOMA index. Uric Acid 49-58 insulin Homo sapiens 169-176
29916994-10 2018 Moreover, in a multiple regression analysis, uric acid was significantly related with male sex, waist circumference, both office and night-time SBP and birth weight. Uric Acid 45-54 selenium binding protein 1 Homo sapiens 144-147
29916994-11 2018 CONCLUSION: The present study found a positive association between uric acid and blood pressure, insulin and triglycerides. Uric Acid 67-76 insulin Homo sapiens 97-104
30126234-8 2018 Uric acid (1mM) a natural scavenger of OONO prevented the OONO mediated SGLT1 inhibition. Uric Acid 0-9 solute carrier family 5 member 1 Homo sapiens 72-77
30015934-1 2018 Genome-wide association studies identified that a series of genes, including solute carrier family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP-binding cassette sub-family G member 2 (ABCG2) polymorphisms were associated with serum uric acid (SUA) levels in the present study. Uric Acid 250-259 solute carrier family 2 member 9 Homo sapiens 77-115
30015934-1 2018 Genome-wide association studies identified that a series of genes, including solute carrier family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP-binding cassette sub-family G member 2 (ABCG2) polymorphisms were associated with serum uric acid (SUA) levels in the present study. Uric Acid 250-259 solute carrier family 2 member 9 Homo sapiens 117-123
30015934-1 2018 Genome-wide association studies identified that a series of genes, including solute carrier family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP-binding cassette sub-family G member 2 (ABCG2) polymorphisms were associated with serum uric acid (SUA) levels in the present study. Uric Acid 250-259 solute carrier family 22 member 12 Homo sapiens 144-152
30015934-1 2018 Genome-wide association studies identified that a series of genes, including solute carrier family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP-binding cassette sub-family G member 2 (ABCG2) polymorphisms were associated with serum uric acid (SUA) levels in the present study. Uric Acid 250-259 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 158-200
30015934-1 2018 Genome-wide association studies identified that a series of genes, including solute carrier family (SLC) 2 member 9 (SLC2A9), SLC 22 member 12 (SLC22A12) and ATP-binding cassette sub-family G member 2 (ABCG2) polymorphisms were associated with serum uric acid (SUA) levels in the present study. Uric Acid 250-259 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 202-207
30249938-11 2018 Moreover, the effect of low serum albumin on the risk of MCI was further enhanced among the subjects with hypertension, diabetes, hyperlipemia, cardiovascular disease, cerebrovascular disease, high serum levels of C-reactive protein, or relatively low levels of uric acid or total bilirubin. Uric Acid 262-271 albumin Homo sapiens 34-41
30066887-0 2018 Urate crystals induce macrophage PAF-AH secretion which is differentially regulated by TGFbeta1 and hydrocortisone. Uric Acid 0-5 phospholipase A2 group VII Homo sapiens 33-39
30066887-0 2018 Urate crystals induce macrophage PAF-AH secretion which is differentially regulated by TGFbeta1 and hydrocortisone. Uric Acid 0-5 transforming growth factor beta 1 Homo sapiens 87-95
29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 81-90 insulin Homo sapiens 11-18
29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 81-90 insulin Homo sapiens 176-183
29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 153-162 insulin Homo sapiens 11-18
29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 153-162 insulin Homo sapiens 176-183
30115944-0 2018 The polymorphism rs35767 at IGF1 locus is associated with serum urate levels. Uric Acid 64-69 insulin like growth factor 1 Homo sapiens 28-32
30349765-1 2018 Background Plasma uric acid has been shown to be associated with an increased risk of hypertension, cardiovascular disease, chronic kidney disease, insulin resistance, and metabolic syndrome. Uric Acid 18-27 insulin Homo sapiens 148-155
30349765-3 2018 The present study aimed to evaluate plasma uric acid levels in type 2 diabetic patients and to determine the effects of hypoglycemic drugs and pharmacologic insulin on plasma uric acid concentration. Uric Acid 175-184 insulin Homo sapiens 157-164
30115944-1 2018 Previous studies suggested that the IGF-1/IGF-1 receptor signaling pathway may contribute to regulate uric acid levels. Uric Acid 102-111 insulin like growth factor 1 Homo sapiens 36-41
30115944-7 2018 Individuals carrying the IGF-1-raising allele (rs35767 T) exhibited significantly lower levels of serum urate according to both additive and recessive models, after correction for gender, age, BMI, glucose tolerance, glomerular filtration rate, and anti-hypertensive treatment. Uric Acid 104-109 insulin like growth factor 1 Homo sapiens 25-30
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 75-84 insulin like growth factor 1 Homo sapiens 28-33
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 75-84 ATP binding cassette subfamily C member 4 Homo sapiens 130-134
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 75-84 solute carrier family 17 member 1 Homo sapiens 136-140
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 109-118 insulin like growth factor 1 Homo sapiens 28-33
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 109-118 ATP binding cassette subfamily C member 4 Homo sapiens 130-134
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 109-118 insulin like growth factor 1 Homo sapiens 28-33
30115944-9 2018 Exposure of HEK293 cells to IGF-1 resulted in a dose-dependent increase of uric acid transporters deputed to uric acid excretion (MRP4, NPT1 and BCRP), and reduction of GLUT9 expression, the major mediator of uric acid reabsorption, both at mRNA and protein level. Uric Acid 109-118 ATP binding cassette subfamily C member 4 Homo sapiens 130-134
30115944-10 2018 We observed a significant association between the functional polymorphism rs35767 near IGF1 with serum urate concentrations and we provide a mechanistic explanation supporting a causal role for IGF-1 in the regulation of uric acid homeostasis. Uric Acid 103-108 insulin like growth factor 1 Homo sapiens 87-91
30115944-10 2018 We observed a significant association between the functional polymorphism rs35767 near IGF1 with serum urate concentrations and we provide a mechanistic explanation supporting a causal role for IGF-1 in the regulation of uric acid homeostasis. Uric Acid 103-108 insulin like growth factor 1 Homo sapiens 194-199
30115944-10 2018 We observed a significant association between the functional polymorphism rs35767 near IGF1 with serum urate concentrations and we provide a mechanistic explanation supporting a causal role for IGF-1 in the regulation of uric acid homeostasis. Uric Acid 221-230 insulin like growth factor 1 Homo sapiens 87-91
30115944-10 2018 We observed a significant association between the functional polymorphism rs35767 near IGF1 with serum urate concentrations and we provide a mechanistic explanation supporting a causal role for IGF-1 in the regulation of uric acid homeostasis. Uric Acid 221-230 insulin like growth factor 1 Homo sapiens 194-199
30110943-8 2018 Furthermore, NZS decreased the expression levels of adipogenesis-related genes and xanthine oxidoreductase (XOR), which is involved in uric acid production, while increasing that of proteins associated with fatty acid oxidation. Uric Acid 135-144 xanthine dehydrogenase Mus musculus 83-106
30110943-8 2018 Furthermore, NZS decreased the expression levels of adipogenesis-related genes and xanthine oxidoreductase (XOR), which is involved in uric acid production, while increasing that of proteins associated with fatty acid oxidation. Uric Acid 135-144 xanthine dehydrogenase Mus musculus 108-111
29955837-2 2018 Uric acid may contribute to insulin resistance and dyslipidemia in the general population. Uric Acid 0-9 insulin Homo sapiens 28-35
29774469-0 2018 Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals. Uric Acid 23-32 insulin Homo sapiens 63-70
29774469-2 2018 The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. Uric Acid 63-72 insulin Homo sapiens 149-156
29774469-2 2018 The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. Uric Acid 74-76 insulin Homo sapiens 149-156
29774469-6 2018 RESULTS: Subjects with higher levels of UA displayed an unfavorable metabolic phenotype with a worse lipid profile, increased levels of 2-h post-load glucose levels, fasting, and 2-h post-load insulin levels, hsCRP, liver IR index, and lower levels of eGFR and skeletal muscle insulin sensitivity, in comparison to individuals with lower UA levels. Uric Acid 40-42 insulin Homo sapiens 193-200
29774469-6 2018 RESULTS: Subjects with higher levels of UA displayed an unfavorable metabolic phenotype with a worse lipid profile, increased levels of 2-h post-load glucose levels, fasting, and 2-h post-load insulin levels, hsCRP, liver IR index, and lower levels of eGFR and skeletal muscle insulin sensitivity, in comparison to individuals with lower UA levels. Uric Acid 40-42 epidermal growth factor receptor Homo sapiens 252-256
29774469-7 2018 Moreover, subjects with higher UA concentrations exhibited decreased levels of insulin clearance even after adjustment for age, gender, BMI, eGFR, and skeletal muscle insulin sensitivity. Uric Acid 31-33 insulin Homo sapiens 79-86
29774469-7 2018 Moreover, subjects with higher UA concentrations exhibited decreased levels of insulin clearance even after adjustment for age, gender, BMI, eGFR, and skeletal muscle insulin sensitivity. Uric Acid 31-33 epidermal growth factor receptor Homo sapiens 141-145
29749099-1 2018 titled "Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" unsubstantiated". Uric Acid 85-94 solute carrier family 5 member 2 Homo sapiens 145-150
29774469-8 2018 In a multivariate regression analysis model including several confounding factors, UA concentration was an independent predictor of insulin clearance (beta = - 0.145; P = 0.03). Uric Acid 83-85 insulin Homo sapiens 132-139
29774469-9 2018 However, when liver IR index was included in the model, the independent association between UA levels and insulin clearance was not retained. Uric Acid 92-94 insulin Homo sapiens 106-113
29774469-10 2018 Accordingly, in a mediation analysis, liver IR index was a mediator of the negative effects of UA levels on insulin clearance (t = - 2.55, P = 0.01). Uric Acid 95-97 insulin Homo sapiens 108-115
29774469-11 2018 CONCLUSIONS: Higher serum levels of UA may affect insulin clearance by impairing hepatic insulin sensitivity. Uric Acid 36-38 insulin Homo sapiens 50-57
29733945-1 2018 Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid. Uric Acid 199-208 xanthine dehydrogenase Homo sapiens 0-23
29733945-1 2018 Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid. Uric Acid 199-208 xanthine dehydrogenase Homo sapiens 25-28
29372470-11 2018 Topiroxostat provides strict control of the serum uric acid level preventing decline of eGFR in these patients. Uric Acid 50-59 epidermal growth factor receptor Homo sapiens 88-92
29660244-0 2018 Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin" unsubstantiated. Uric Acid 77-86 solute carrier family 5 member 2 Homo sapiens 137-142
29570819-3 2018 (i) Insulin is considered to stimulate uric acid reabsorption via specific transporter and the effect of hyperuricaemia on the new-onset T2DM should be evaluated by considering insulin resistance. Uric Acid 39-48 insulin Homo sapiens 4-11
29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 C-reactive protein Homo sapiens 109-112
29803701-4 2018 Among the genes in this region, we focused on Bombyx homolog of mammalian Gephyrin (BmGphn), which regulates molybdenum cofactor (MoCo) biosynthesis, because MoCo is indispensable for the activity of xanthine dehydrogenase (XDH), a key enzyme in uric acid biosynthesis. Uric Acid 246-255 gephyrin Homo sapiens 74-82
29856171-9 2018 Insulin resistance is thought to alter the renal acid-base metabolism, resulting in a lower urine pH, and increasing the risk of uric acid stone disease. Uric Acid 129-138 insulin Homo sapiens 0-7
29748702-7 2018 Serum renalase was strongly related to serum uric acid levels. Uric Acid 45-54 renalase, FAD dependent amine oxidase Homo sapiens 6-14
29748702-10 2018 Special attention should be drawn to the correlation between renalase and serum uric acid levels not only in hypertensive, but also in normotensive teenagers. Uric Acid 80-89 renalase, FAD dependent amine oxidase Homo sapiens 61-69
29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 interleukin 6 Homo sapiens 114-118
29789205-5 2018 We examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 1451 cases and 3135 matched controls. Uric Acid 110-115 solute carrier family 2 member 9 Homo sapiens 75-81
29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 tumor necrosis factor Homo sapiens 120-129
29789205-7 2018 RESULTS: We found the expected associations between SNPs in SLC2A9 and plasma urate levels among men and women; however, SNPs in other genes tended not to be associated with urate. Uric Acid 78-83 solute carrier family 2 member 9 Homo sapiens 60-66
29789205-8 2018 Each SNP in SLC2A9 explained less than 7% of the variance in plasma urate. Uric Acid 68-73 solute carrier family 2 member 9 Homo sapiens 12-18
29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 cystatin C Homo sapiens 196-206
29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 interleukin 10 Homo sapiens 279-284
29530253-4 2018 Uricase has been selected as model enzyme and several parameters (temperature, pH, reaction time, buffer, and enzyme concentration) have been optimised to demonstrate the versatility of this novel multifunctional material in the development of biosensors with optical oxygen transduction for determining uric acid in serum samples. Uric Acid 304-313 urate oxidase (pseudogene) Homo sapiens 0-7
30032413-8 2018 In addition, the sensitivity for DA and UA is 0.538 and 0.156 muA muM-1 cm-2, respectively. Uric Acid 40-42 PWWP domain containing 3A, DNA repair factor Homo sapiens 66-76
32254405-6 2018 The linear ranges are 0.001-1.5 mM, 0.05-160 muM and 0.001-0.875 mM for AA, DA and UA, and the corresponding detection limits are 0.3 muM, 20 nM and 0.3 muM, respectively. Uric Acid 83-85 latexin Homo sapiens 134-137
32254405-6 2018 The linear ranges are 0.001-1.5 mM, 0.05-160 muM and 0.001-0.875 mM for AA, DA and UA, and the corresponding detection limits are 0.3 muM, 20 nM and 0.3 muM, respectively. Uric Acid 83-85 latexin Homo sapiens 134-137
30830393-9 2018 TAP samples were characterized by increases in reduced glutathione and decreases in urate and cystine, markers of oxidation of purines and cysteine-overall suggesting decreased oxidation during draws. Uric Acid 84-89 nuclear RNA export factor 1 Homo sapiens 0-3
29976226-2 2018 Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). Uric Acid 135-140 glucokinase regulator Homo sapiens 24-28
29976226-2 2018 Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). Uric Acid 135-140 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 30-35
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 glucokinase regulator Homo sapiens 21-25
29976226-2 2018 Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). Uric Acid 135-140 MLX interacting protein like Homo sapiens 37-43
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 MLX interacting protein like Homo sapiens 34-40
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 46-52
29976226-2 2018 Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). Uric Acid 135-140 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 49-55
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 152-158
29717279-6 2018 RESULTS: In combined data of the two cohorts, the cross-lagged path coefficient (beta1 = 0.121; 95% confidence interval (CI): 0.108-0.135) from baseline uric acid to the follow-up BMI was significantly greater than the path coefficient (beta2 = 0.055, 95% CI: 0.038-0.072) from baseline BMI to the follow-up uric acid (P = 8.14e-10 for the difference between beta1 and beta2) with adjustment for covariates. Uric Acid 153-162 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 81-86
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 MLX interacting protein like Homo sapiens 192-198
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 glucokinase regulator Homo sapiens 255-259
29976226-10 2018 The urate-increasing GCKR, ABCG2, MLXIPL, and CYP1A2 alleles were associated with reduced daily coffee consumption, with the strongest associations for CYP1A2 (beta -0.30, P = 8 x 10-40), and MLXIPL (beta -0.17, P = 3 x 10-8), and weaker associations for GCKR (beta -0.07, P = 3 x 10-10) and ABCG2 (beta -0.09, P = 2 x 10-9). Uric Acid 4-9 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 292-297
29976226-11 2018 The urate-increasing GCKR and ABCG2 alleles were associated with gout (multivariate adjusted p < 5 x 10-8 for both), but the urate-increasing MLXIPL and CYP1A2 alleles were not. Uric Acid 4-9 glucokinase regulator Homo sapiens 21-25
29976226-11 2018 The urate-increasing GCKR and ABCG2 alleles were associated with gout (multivariate adjusted p < 5 x 10-8 for both), but the urate-increasing MLXIPL and CYP1A2 alleles were not. Uric Acid 128-133 MLX interacting protein like Homo sapiens 145-151
30342848-8 2018 RESULTS: CCl4 caused a significant elevation of liver enzymes, lactic acid dehydrogenase, blood glucose, uric acid, blood urea and serum creatinine as compared to the control group. Uric Acid 105-114 C-C motif chemokine ligand 4 Rattus norvegicus 9-13
29683202-2 2018 Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1beta and result in vigorous inflammation. Uric Acid 28-37 NLR family pyrin domain containing 3 Homo sapiens 51-88
29683202-2 2018 Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1beta and result in vigorous inflammation. Uric Acid 28-37 interleukin 1 beta Homo sapiens 113-135
29683202-4 2018 We confirmed that serum total cholesterol and uric acid were elevated in pre-eclamptic compared to healthy pregnancies and correlated positively to high sensitivity C-reactive protein (hsCRP) and the pre-eclampsia marker soluble fms-like tyrosine kinase-1 (sFlt-1). Uric Acid 46-55 C-reactive protein Homo sapiens 165-183
29763636-0 2018 Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Uric Acid 78-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-19
29763636-0 2018 Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Uric Acid 78-94 prostaglandin E synthase Mus musculus 20-27
29763636-0 2018 Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Uric Acid 78-94 arachidonate 5-lipoxygenase Homo sapiens 32-37
30377595-9 2018 Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). Uric Acid 42-51 C-C motif chemokine ligand 4 Rattus norvegicus 9-13
29717279-6 2018 RESULTS: In combined data of the two cohorts, the cross-lagged path coefficient (beta1 = 0.121; 95% confidence interval (CI): 0.108-0.135) from baseline uric acid to the follow-up BMI was significantly greater than the path coefficient (beta2 = 0.055, 95% CI: 0.038-0.072) from baseline BMI to the follow-up uric acid (P = 8.14e-10 for the difference between beta1 and beta2) with adjustment for covariates. Uric Acid 308-317 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 81-86
29717279-8 2018 Further, the path coefficient (beta1) from baseline uric acid to follow-up BMI in the group with diabetes was significantly greater than without diabetes (P = 0.003 for the difference of beta1s in the two groups). Uric Acid 52-61 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 31-36
30423175-1 2018 Objectives: Phosphoribosylpyrophosphate synthetase (PRPS1) superactivity is an X-linked disorder characterized by urate overproduction Online Mendelian Inheritance in Man (OMIM) gene reference 300661. Uric Acid 114-119 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 52-57
29720497-7 2018 Intriguingly, transport efficiencies are significantly higher for OAT1 orthologs from apes with high serum uric acid (SUA) levels than for the orthologs from species with low serum uric acid levels. Uric Acid 107-116 solute carrier family 22 member 6 Homo sapiens 66-70
29720497-7 2018 Intriguingly, transport efficiencies are significantly higher for OAT1 orthologs from apes with high serum uric acid (SUA) levels than for the orthologs from species with low serum uric acid levels. Uric Acid 181-190 solute carrier family 22 member 6 Homo sapiens 66-70
29877616-1 2018 OBJECTIVE: The production of uric acid in murine white adipose tissue (mWAT), and that such production was augmented in obese mice, was recently reported. Uric Acid 29-38 WD and tetratricopeptide repeats 1 Mus musculus 55-62
30423175-9 2018 Conclusion: Clinical findings in previously reported females with PRPS1 superactivity showed a high clinical penetrance of this disorder with a mean serum urate level of 8.5 (4.1) mg/dl [506 (247) mumol/l] and a high prevalence of gout. Uric Acid 155-160 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 66-71
29643318-1 2018 BACKGROUND: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Uric Acid 87-96 xanthine dehydrogenase Homo sapiens 12-35
30378301-0 2018 [Soluble Uric Acid Activates NLRP3 Inflammasome in Myocardial Cells Through Down-regulating UCP2]. Uric Acid 9-18 NLR family, pyrin domain containing 3 Rattus norvegicus 29-34
30378301-0 2018 [Soluble Uric Acid Activates NLRP3 Inflammasome in Myocardial Cells Through Down-regulating UCP2]. Uric Acid 9-18 uncoupling protein 2 Rattus norvegicus 92-96
30378301-1 2018 OBJECTIVE: To determine the H9C2 cell damage and NLRP3 inflammasome activation trigged by soluble uric acid (UA). Uric Acid 98-107 NLR family, pyrin domain containing 3 Rattus norvegicus 49-54
30378301-1 2018 OBJECTIVE: To determine the H9C2 cell damage and NLRP3 inflammasome activation trigged by soluble uric acid (UA). Uric Acid 109-111 NLR family, pyrin domain containing 3 Rattus norvegicus 49-54
30378301-10 2018 UA up-regulated the expression of NLRP3 inflammasome-related molecules. Uric Acid 0-2 NLR family, pyrin domain containing 3 Rattus norvegicus 34-39
30378301-13 2018 UA down-regulated the expression of UCP2. Uric Acid 0-2 uncoupling protein 2 Rattus norvegicus 36-40
30378301-14 2018 CONCLUSION: Soluble UA can down-regulate the expression of UCP2, damage the mitochondria and activate NLRP3 inflammasome, resulting in cellular damage of H9C2 cells. Uric Acid 20-22 uncoupling protein 2 Rattus norvegicus 59-63
30378301-14 2018 CONCLUSION: Soluble UA can down-regulate the expression of UCP2, damage the mitochondria and activate NLRP3 inflammasome, resulting in cellular damage of H9C2 cells. Uric Acid 20-22 NLR family, pyrin domain containing 3 Rattus norvegicus 102-107
29643318-1 2018 BACKGROUND: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Uric Acid 87-96 xanthine dehydrogenase Homo sapiens 37-40
29643318-3 2018 We investigated the associations between metabolic parameters and plasma XOR activity measured by a sensitive and accurate assay using a combination of liquid chromatography and triple quadrupole mass spectrometry to detect [13C2,15N2]-uric acid using [13C2,15N2]-xanthine as a substrate.Methods and Results:A total of 627 Japanese subjects (M/F, 292/335) from the Tanno-Sobetsu Study, a population-based cohort, were recruited. Uric Acid 236-245 xanthine dehydrogenase Homo sapiens 73-76
29643318-6 2018 On stepwise and multivariate regression analyses, BMI, smoking and levels of alanine transaminase, uric acid, triglycerides and HOMA-R were independent predictors of plasma XOR activity after adjustment for age and gender. Uric Acid 99-108 xanthine dehydrogenase Homo sapiens 173-176
29357410-7 2018 Finally, the aged THP KO mice had significant upregulation of Na-coupled urate transporters Slc5a8 and Slc22a12 as well as sodium-hydrogen exchanger 3 (NHE3) in the proximal tubule and elevated serum uric acid and allantoin. Uric Acid 200-209 uromodulin Mus musculus 18-21
29159872-4 2018 Besides their role in glucose uptake, GLUT transporters are able to transport other compounds such as dehydroascorbic acid or uric acid. Uric Acid 126-135 solute carrier family 2 member 1 Homo sapiens 38-42
29496260-6 2018 Although several small clinical trials suggest benefits of urate-lowering therapies on kidney function, blood pressure, and insulin resistance, others have been negative, with many trials having design limitations and insufficient power. Uric Acid 59-64 insulin Homo sapiens 124-131
30046344-10 2018 The mechanisms of ShiZhiFang on uric acid metabolism in hyperuricemic rats may be involved in reducing the activity of serum XOD and promoting the transcription and expression of rOAT1 and rOAT3 in the kidney. Uric Acid 32-41 solute carrier family 22 member 6 Rattus norvegicus 179-184
30046344-10 2018 The mechanisms of ShiZhiFang on uric acid metabolism in hyperuricemic rats may be involved in reducing the activity of serum XOD and promoting the transcription and expression of rOAT1 and rOAT3 in the kidney. Uric Acid 32-41 solute carrier family 22 member 8 Rattus norvegicus 189-194
29967582-0 2018 Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate. Uric Acid 64-69 solute carrier family 2 member 9 Homo sapiens 19-25
29967582-0 2018 Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate. Uric Acid 64-69 solute carrier family 2 member 9 Homo sapiens 27-32
29967582-2 2018 Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs) were associated with lower serum urate, further indicating that Glut9 is a major determinant of serum uric acid level. Uric Acid 165-170 solute carrier family 2 member 9 Homo sapiens 196-201
29967582-2 2018 Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs) were associated with lower serum urate, further indicating that Glut9 is a major determinant of serum uric acid level. Uric Acid 234-243 solute carrier family 2 member 9 Homo sapiens 6-11
29967582-2 2018 Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs) were associated with lower serum urate, further indicating that Glut9 is a major determinant of serum uric acid level. Uric Acid 234-243 solute carrier family 2 member 9 Homo sapiens 196-201
29710530-0 2018 Resveratrol improves uric acid-induced pancreatic beta-cells injury and dysfunction through regulation of miR-126. Uric Acid 21-30 microRNA 126a Mus musculus 106-113
29266345-12 2018 Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Uric Acid 136-145 insulin Homo sapiens 164-171
29486147-1 2018 BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in SLC22A12 or SLC2A9. Uric Acid 91-100 solute carrier family 22 member 12 Homo sapiens 169-177
29486147-1 2018 BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in SLC22A12 or SLC2A9. Uric Acid 91-100 solute carrier family 2 member 9 Homo sapiens 181-187
29486147-1 2018 BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in SLC22A12 or SLC2A9. Uric Acid 102-104 solute carrier family 22 member 12 Homo sapiens 169-177
29486147-1 2018 BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in SLC22A12 or SLC2A9. Uric Acid 102-104 solute carrier family 2 member 9 Homo sapiens 181-187
29266345-12 2018 Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Uric Acid 136-145 insulin Homo sapiens 187-194
29382583-1 2018 Xanthine oxidase (XOD) is a key enzyme that catalyzes xanthine to uric acid. Uric Acid 66-75 xanthine dehydrogenase Mus musculus 0-16
29382583-1 2018 Xanthine oxidase (XOD) is a key enzyme that catalyzes xanthine to uric acid. Uric Acid 66-75 xanthine dehydrogenase Mus musculus 18-21
29382583-2 2018 Most of the urate-lowering medicines targeting XOD have a limited effect on alleviating inflammation in spite of significant effects on decreasing serum uric acid level. Uric Acid 12-17 xanthine dehydrogenase Mus musculus 47-50
29382583-9 2018 For the first time, these results showed that the anti-XOD mAb may serve as a promising therapeutic approach for inflammatory response related to uric acid. Uric Acid 146-155 xanthine dehydrogenase Mus musculus 55-58
29879316-0 2018 GLUT9 influences uric acid concentration in patients with Lesch-Nyhan disease. Uric Acid 17-26 solute carrier family 2 member 9 Homo sapiens 0-5
29879316-7 2018 RESULTS: Patients with HPRT deficiency having allele A of rs16890979 in the GLUT9 gene present with a lower serum urate concentration at diagnosis, before allopurinol treatment is instituted, and need lower allopurinol doses to maintain serum urate levels between 268 and 446 mumol/L (4.5 and 7.5 mg/dL). Uric Acid 114-119 solute carrier family 2 member 9 Homo sapiens 76-81
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 207-216 solute carrier family 2 member 9 Homo sapiens 120-125
29879316-7 2018 RESULTS: Patients with HPRT deficiency having allele A of rs16890979 in the GLUT9 gene present with a lower serum urate concentration at diagnosis, before allopurinol treatment is instituted, and need lower allopurinol doses to maintain serum urate levels between 268 and 446 mumol/L (4.5 and 7.5 mg/dL). Uric Acid 243-248 solute carrier family 2 member 9 Homo sapiens 76-81
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 207-216 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 127-132
29879316-9 2018 CONCLUSIONS: GLUT9 SNPs influence the renal handling of uric acid and modulate serum urate levels and the response to treatment in patients with uric acid overproduction due to HPRT deficiency. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 13-18
29879316-9 2018 CONCLUSIONS: GLUT9 SNPs influence the renal handling of uric acid and modulate serum urate levels and the response to treatment in patients with uric acid overproduction due to HPRT deficiency. Uric Acid 85-90 solute carrier family 2 member 9 Homo sapiens 13-18
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 207-216 solute carrier family 22 member 12 Homo sapiens 137-142
29879316-9 2018 CONCLUSIONS: GLUT9 SNPs influence the renal handling of uric acid and modulate serum urate levels and the response to treatment in patients with uric acid overproduction due to HPRT deficiency. Uric Acid 145-154 solute carrier family 2 member 9 Homo sapiens 13-18
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 39-44 solute carrier family 2 member 9 Homo sapiens 120-125
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 39-44 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 127-132
29879316-4 2018 In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels. Uric Acid 39-44 solute carrier family 22 member 12 Homo sapiens 137-142
29879316-5 2018 In the present study, we analyzed whether GLUT9, ABCG2 and URAT1 gene SNPs are able to influence uric acid levels and allopurinol response in patients with HPRT deficiency. Uric Acid 97-106 solute carrier family 2 member 9 Homo sapiens 42-47
29879316-5 2018 In the present study, we analyzed whether GLUT9, ABCG2 and URAT1 gene SNPs are able to influence uric acid levels and allopurinol response in patients with HPRT deficiency. Uric Acid 97-106 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 49-54
29879316-5 2018 In the present study, we analyzed whether GLUT9, ABCG2 and URAT1 gene SNPs are able to influence uric acid levels and allopurinol response in patients with HPRT deficiency. Uric Acid 97-106 solute carrier family 22 member 12 Homo sapiens 59-64
29524120-4 2018 The discovery of the role of interleukin-1beta (IL-1beta) in orchestrating the monosodium urate crystal-induced inflammatory response offered new therapeutic prospects to refractory patients, or to those in whom standard therapies are contraindicated. Uric Acid 79-95 interleukin 1 beta Homo sapiens 29-46
29510342-1 2018 Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Uric Acid 0-9 myeloperoxidase Homo sapiens 110-125
29510342-4 2018 While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha). Uric Acid 76-85 interleukin 1 beta Homo sapiens 168-185
29510342-4 2018 While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha). Uric Acid 76-85 interleukin 1 beta Homo sapiens 187-195
29510342-4 2018 While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha). Uric Acid 76-85 tumor necrosis factor Homo sapiens 201-228
29510342-4 2018 While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha). Uric Acid 76-85 tumor necrosis factor Homo sapiens 230-240
29510342-5 2018 In a myeloperoxidase/Cl-/H2O2 cell-free system, uric acid inhibited the production of HOCl and bacterial killing. Uric Acid 48-57 myeloperoxidase Homo sapiens 5-20
29510342-8 2018 Our data show that uric acid impairs the killing activity of dHL-60 cells likely by competing with chloride by myeloperoxidase catalysis, decreasing HOCl production. Uric Acid 19-28 myeloperoxidase Homo sapiens 111-126
29511302-2 2018 Allopurinol (ALLO) inhibits xanthine oxidase (XOD) activity, and, consequently, reduces the production of uric acid (UA) and reactive oxygen species (ROS), both of which can activate the NLRP3 pathway. Uric Acid 106-115 NLR family, pyrin domain containing 3 Rattus norvegicus 187-192
29511302-2 2018 Allopurinol (ALLO) inhibits xanthine oxidase (XOD) activity, and, consequently, reduces the production of uric acid (UA) and reactive oxygen species (ROS), both of which can activate the NLRP3 pathway. Uric Acid 117-119 NLR family, pyrin domain containing 3 Rattus norvegicus 187-192
29075989-5 2018 Women with UA level >= 4 mg/dL were characterized by larger body mass, triceps skinfold, waist circumference, body fat amount, and serum insulin, glucose, and triglyceride levels. Uric Acid 11-13 insulin Homo sapiens 140-147
29524120-4 2018 The discovery of the role of interleukin-1beta (IL-1beta) in orchestrating the monosodium urate crystal-induced inflammatory response offered new therapeutic prospects to refractory patients, or to those in whom standard therapies are contraindicated. Uric Acid 79-95 interleukin 1 beta Homo sapiens 48-56
29607709-11 2018 In contrast, obesity is associated with an increased risk of uric acid stone formation due to insulin resistance, impaired ammoniagenesis and low urinary pH. Uric Acid 61-70 insulin Homo sapiens 94-101
29950221-6 2018 The RELN high expression group showed higher levels of serum M protein, uric acid and serum calcium, lower hemoglobin, and more abnormal FISH results (including RB1 deletion, 1q21 amplification, IgH recombination, P53 deletion, D13S319 deletion) than those in RELN low expression group. Uric Acid 72-81 reelin Homo sapiens 4-8
29749379-2 2018 ABCG2 is also involved in uric acid elimination and its impaired function is causative in gout. Uric Acid 26-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
29412948-3 2018 Owing to the unique structure and properties originating from the enhanced surface area, nitrogen functional groups and defects introduced on both the basal and edges, N2/Ar/GS/GNR/GCE showed high electrocatalytic activity for the electrochemical oxidations of AA, DA, and UA with the respective lowest detection limits of 5.3, 2.5 and 5.7 nM and peak-to-peak separation potential (DeltaEP) (vs Ag/AgCl) in DPV of 220, 152 and 372 mV for AA/DA, DA/UA and AA/UA respectively. Uric Acid 273-275 guanylate cyclase 2E, pseudogene Homo sapiens 168-184
29567078-10 2018 KEY FINDINGS: The IP administration of BCA significantly decreased serum levels of urea, creatinine, uric acid and MDA and significantly increased serum CAT, GSH and TAC and cutaneous IL-4 and GATA3 concentrations in the fifth and sixth groups compared to OVX-DMSO and OVX-ANA groups, respectively. Uric Acid 101-110 B cell linker Homo sapiens 39-42
29684895-1 2018 Xanthine oxidase, which catalyzes the oxidative reaction of hypoxanthine and xanthine into uric acid, is a key enzyme to the pathogenesis of hyperuricemia and gout. Uric Acid 91-100 xanthine dehydrogenase Mus musculus 0-16
29780394-2 2018 Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 84-89
29546904-2 2018 Based on this strategy, we developed two biosensors for the detection of an antiseptic, p-hydroxybenzoic acid, and a disease marker, uric acid, using bacterial aTF HosA and HucR, respectively, highlighting the great potential of this strategy for the development of small-molecule biosensors. Uric Acid 133-142 glial cell derived neurotrophic factor Homo sapiens 160-163
29780394-2 2018 Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals. Uric Acid 134-143 NLR family pyrin domain containing 3 Homo sapiens 84-89
29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 126-131
29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 PYD and CARD domain containing Homo sapiens 133-136
29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 interleukin 18 Homo sapiens 142-147
29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 caspase 8 Homo sapiens 177-186
29518608-10 2018 Similar results were observed in uric acid-incubated cells with RIP3 knockdown. Uric Acid 33-42 receptor-interacting serine-threonine kinase 3 Mus musculus 64-68
29317200-0 2018 Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells. Uric Acid 37-42 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 97-102
29317200-11 2018 These uric acid-induced changes of BCRP and Akt were reversed in the presence of the antioxidant N-acetylcysteine. Uric Acid 6-15 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 35-39
29317200-11 2018 These uric acid-induced changes of BCRP and Akt were reversed in the presence of the antioxidant N-acetylcysteine. Uric Acid 6-15 AKT serine/threonine kinase 1 Homo sapiens 44-47
29317200-12 2018 These results suggest that in hyperuricemia, uric acid-induced ROS generation inhibits Akt phosphorylation, causing a decrease in plasma membrane localization of BCRP, and the resulting decrease of BCRP-mediated efflux leads to increased uric acid accumulation and dysregulation of endothelial function. Uric Acid 45-54 AKT serine/threonine kinase 1 Homo sapiens 87-90
29720230-11 2018 RESULTS: In cultured BV2 cells and rat primary microglia, urate suppressed proinflammatory cytokine production and inducible cyclooxygenase 2 and nitric oxide synthase expression to protect dopaminergic neurons from the toxic effects of activated microglia. Uric Acid 58-63 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 125-141
29720230-12 2018 The neuroprotective effects of urate may also be associated with the stimulation of anti-inflammatory factors interleukin 10 and transforming growth factor beta1. Uric Acid 31-36 interleukin 10 Rattus norvegicus 110-161
29720230-16 2018 Additionally, increased plasma urate level abolished the reduction of URAT1 expression, the increase in the expression of interleukin-1beta, and the number of ionized calcium-binding adaptor molecule 1-positive microglia along with changes in their morphology. Uric Acid 31-36 interleukin 1 beta Rattus norvegicus 122-139
29317200-12 2018 These results suggest that in hyperuricemia, uric acid-induced ROS generation inhibits Akt phosphorylation, causing a decrease in plasma membrane localization of BCRP, and the resulting decrease of BCRP-mediated efflux leads to increased uric acid accumulation and dysregulation of endothelial function. Uric Acid 45-54 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 162-166
29317200-12 2018 These results suggest that in hyperuricemia, uric acid-induced ROS generation inhibits Akt phosphorylation, causing a decrease in plasma membrane localization of BCRP, and the resulting decrease of BCRP-mediated efflux leads to increased uric acid accumulation and dysregulation of endothelial function. Uric Acid 45-54 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 198-202
29317200-12 2018 These results suggest that in hyperuricemia, uric acid-induced ROS generation inhibits Akt phosphorylation, causing a decrease in plasma membrane localization of BCRP, and the resulting decrease of BCRP-mediated efflux leads to increased uric acid accumulation and dysregulation of endothelial function. Uric Acid 238-247 AKT serine/threonine kinase 1 Homo sapiens 87-90
29317200-12 2018 These results suggest that in hyperuricemia, uric acid-induced ROS generation inhibits Akt phosphorylation, causing a decrease in plasma membrane localization of BCRP, and the resulting decrease of BCRP-mediated efflux leads to increased uric acid accumulation and dysregulation of endothelial function. Uric Acid 238-247 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 198-202
29341461-0 2018 Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and kidney clearance: Post-hoc analyses of four clinical trials. Uric Acid 75-84 glucagon like peptide 1 receptor Homo sapiens 34-48
29292186-0 2018 Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome. Uric Acid 10-19 insulin Homo sapiens 43-50
29292186-11 2018 The interaction between uric acid and insulin was associated with the number of MetS components (PROCESS Model 1, interaction coefficient = -0.009, 95%CI: -0.017 to -0.001, p = .036). Uric Acid 24-33 insulin Homo sapiens 38-45
29341461-1 2018 AIMS: To determine the effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance. Uric Acid 90-99 glucagon like peptide 1 receptor Homo sapiens 34-72
29341461-1 2018 AIMS: To determine the effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance. Uric Acid 101-103 glucagon like peptide 1 receptor Homo sapiens 34-72
28880687-0 2018 TNF-alpha potentiates uric acid-induced interleukin-1beta (IL-1beta) secretion in human neutrophils. Uric Acid 22-31 tumor necrosis factor Homo sapiens 0-9
29718786-12 2018 CA125 level also correlated positively with systolic blood pressure (r = 0.406, P < 0.05), diastolic blood pressure (r = 0.433, P < 0.05), serum uric acid levels (r = 0.407, P = 0.001), platelet levels (r = 0.341, P = 0.001), and urinary protein levels (r = 0.325, P = 0.002). Uric Acid 151-160 mucin 16, cell surface associated Homo sapiens 0-5
28880687-0 2018 TNF-alpha potentiates uric acid-induced interleukin-1beta (IL-1beta) secretion in human neutrophils. Uric Acid 22-31 interleukin 1 beta Homo sapiens 40-57
28880687-0 2018 TNF-alpha potentiates uric acid-induced interleukin-1beta (IL-1beta) secretion in human neutrophils. Uric Acid 22-31 interleukin 1 beta Homo sapiens 59-67
28880687-1 2018 OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive. Uric Acid 11-27 interleukin 1 beta Homo sapiens 60-77
28880687-1 2018 OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive. Uric Acid 11-27 interleukin 1 beta Homo sapiens 79-87
28880687-1 2018 OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive. Uric Acid 11-27 NLR family pyrin domain containing 3 Homo sapiens 199-204
28880687-9 2018 CONCLUSION: Our data demonstrate that priming of human neutrophils with TNF-alpha promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation. Uric Acid 91-100 tumor necrosis factor Homo sapiens 72-81
28880687-9 2018 CONCLUSION: Our data demonstrate that priming of human neutrophils with TNF-alpha promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation. Uric Acid 91-100 interleukin 1 beta Homo sapiens 110-118
29845779-0 2018 Urate transport function of rat sodium-dependent nucleobase transporter 1. Uric Acid 0-5 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 32-73
29845779-2 2018 In an attempt to search for its potential substrates other than nucleobases in this study, we could successfully find urate, a metabolic derivative of purine nucleobases, as a novel substrate, as indicated by its specific Na+ -dependent and saturable transport, with a Michaelis constant of 433 mumol/L, by rat SNBT1 (rSNBT1) stably expressed in Madin-Darby canine kidney II cells. Uric Acid 118-123 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 311-316
29845779-2 2018 In an attempt to search for its potential substrates other than nucleobases in this study, we could successfully find urate, a metabolic derivative of purine nucleobases, as a novel substrate, as indicated by its specific Na+ -dependent and saturable transport, with a Michaelis constant of 433 mumol/L, by rat SNBT1 (rSNBT1) stably expressed in Madin-Darby canine kidney II cells. Uric Acid 118-123 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 318-324
29845779-3 2018 However, urate uptake was observed only barely in the everted tissue sacs of the rat small intestine, in which rSNBT1 operates for nucleobase uptake. Uric Acid 9-14 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 111-117
29845779-5 2018 In subsequent attempts to examine that possibility, such a futile urate cycle was demonstrated in the human embryonic kidney 293 cell line as a model cell system, where urate uptake induced by transiently introduced rSNBT1 was extensively reduced by the co-introduction of rat breast cancer resistance protein (rBCRP), a urate efflux transporter present in the small intestine. Uric Acid 66-71 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 216-222
29845779-5 2018 In subsequent attempts to examine that possibility, such a futile urate cycle was demonstrated in the human embryonic kidney 293 cell line as a model cell system, where urate uptake induced by transiently introduced rSNBT1 was extensively reduced by the co-introduction of rat breast cancer resistance protein (rBCRP), a urate efflux transporter present in the small intestine. Uric Acid 169-174 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 216-222
29845779-7 2018 The newly found urate transport function of SNBT1, together with the suggested futile urate cycle in the small intestine, should be of interest for its evolutional and biological implications, although SNBT1 is genetically deficient in humans. Uric Acid 16-21 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 44-49
29845779-7 2018 The newly found urate transport function of SNBT1, together with the suggested futile urate cycle in the small intestine, should be of interest for its evolutional and biological implications, although SNBT1 is genetically deficient in humans. Uric Acid 16-21 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 202-207
29845779-7 2018 The newly found urate transport function of SNBT1, together with the suggested futile urate cycle in the small intestine, should be of interest for its evolutional and biological implications, although SNBT1 is genetically deficient in humans. Uric Acid 86-91 similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Rattus norvegicus 44-49
29850377-10 2018 Mutations in these genes may prompt disturbances in UA reabsorption, and could lead to the development of hyperuricaemia, insulin resistance, endothelial dysfunction, diabetes and other metabolic diseases. Uric Acid 52-54 insulin Homo sapiens 122-129
29239351-7 2018 In females, serum uric acid level was significantly associated with osteoporosis, with odds ratio (OR) and 95% confidence interval (95% CI) of 0.844 [0.763; 0.933] (P=0.0009) after adjusting for age, body mass index, HbA1c, lean mass, visceral and subcutaneous fat areas, albumin, 25-hydroxyvitamin D3 [25(OH)D3], and parathyroid hormone (PTH). Uric Acid 18-27 parathyroid hormone Homo sapiens 318-337
29171930-0 2018 Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin. Uric Acid 0-9 solute carrier family 5 member 2 Homo sapiens 60-65
29171930-2 2018 Sex differences, baseline haemoglobin A1c (HbA1c) and serum uric acid (UA) levels, and log10 -transformed urinary N-acetyl-beta-D-glucosaminidase ratio were significantly correlated with the reduction in serum UA levels at both 4 and 24 weeks in multivariate analysis (respectively, P < .0001). Uric Acid 210-212 O-GlcNAcase Homo sapiens 114-145
29656005-9 2018 Thus, a novel animal model created with PZA administration was useful as a urate under-excretion animal model that was probably URAT1-mediated, and the uricosuric effects of dihydropyridine CCBs were confirmed in vivo. Uric Acid 75-80 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 128-133
29124443-8 2018 Among the five SNVs, rs55975541 in CDC42BPG was significantly (P < 4.90 x 10- 4) related to the serum concentration of uric acid in the replication cohort. Uric Acid 122-131 CDC42 binding protein kinase gamma Homo sapiens 35-43
29124443-10 2018 Four SNVs in SLC15A2 were significantly associated with the estimated glomerular filtration rate in European ancestry populations, although these SNVs were related to the serum concentration of uric acid with borderline significance in our longitudinal EWASs. Uric Acid 194-203 solute carrier family 15 member 2 Homo sapiens 13-20
29408531-0 2018 The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study. Uric Acid 54-63 aldehyde dehydrogenase 2 family member Homo sapiens 26-31
29735453-0 2018 [Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus]. Uric Acid 49-58 insulin Homo sapiens 29-38
29735453-1 2018 OBJECTIVE: To explore the relationship between fasting C-peptide (F-CP) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 82-91 insulin Homo sapiens 55-64
29409831-0 2018 Serum uric acid in Friedreich Ataxia. Uric Acid 6-15 frataxin Homo sapiens 19-36
29409831-10 2018 Contrarily to other neurodegenerative diseases, in FRDA, we observed an independent increase of serum UA content. Uric Acid 102-104 frataxin Homo sapiens 51-55
29702981-6 2018 LOX-1 levels were correlated with the levels of uric acid (UA) (r = 0.289, P = .007), creatinine (CREA) (r = .316, P = .003), and high-density lipoprotein cholesterol (HDL-C) (r = -0.271, P = .012), whereas no statistically significant correlation was detected with the Gensini score (r = 0.157, P = .141). Uric Acid 48-57 oxidized low density lipoprotein receptor 1 Homo sapiens 0-5
29702981-6 2018 LOX-1 levels were correlated with the levels of uric acid (UA) (r = 0.289, P = .007), creatinine (CREA) (r = .316, P = .003), and high-density lipoprotein cholesterol (HDL-C) (r = -0.271, P = .012), whereas no statistically significant correlation was detected with the Gensini score (r = 0.157, P = .141). Uric Acid 59-61 oxidized low density lipoprotein receptor 1 Homo sapiens 0-5
29619007-0 2018 Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells. Uric Acid 0-9 insulin Homo sapiens 18-25
29619007-0 2018 Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells. Uric Acid 0-9 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 49-54
29588485-7 2018 Study subjects in the highest tertile of serum uric acid level were older, more likely to be male, and had higher systolic blood pressure, body mass index, carotid artery intima-media thickness and serum triglyceride, high-sensitivity C-reactive protein, and low-density lipoprotein cholesterol levels and lower serum high-density lipoprotein cholesterol levels (all p < 0.05). Uric Acid 47-56 C-reactive protein Homo sapiens 235-253
29619007-0 2018 Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells. Uric Acid 0-9 insulin receptor Homo sapiens 66-82
29619007-9 2018 UA inhibited insulin-induced Akt/eNOS axis. Uric Acid 0-2 insulin Homo sapiens 13-20
29619007-9 2018 UA inhibited insulin-induced Akt/eNOS axis. Uric Acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 29-32
29619007-10 2018 Moreover, UA induced ENPP1 binding to IR that resulted in an impairment of insulin signaling cascade. Uric Acid 10-12 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 21-26
29619007-10 2018 Moreover, UA induced ENPP1 binding to IR that resulted in an impairment of insulin signaling cascade. Uric Acid 10-12 insulin receptor Homo sapiens 38-40
29619007-12 2018 In endothelial cells, UA directly interferes with insulin signaling pathway at receptor level, through ENPP1 recruitment. Uric Acid 22-24 insulin Homo sapiens 50-57
29619007-12 2018 In endothelial cells, UA directly interferes with insulin signaling pathway at receptor level, through ENPP1 recruitment. Uric Acid 22-24 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 103-108
29619007-13 2018 This evidence suggests a new molecular model of UA-induced insulin resistance and vascular damage. Uric Acid 48-50 insulin Homo sapiens 59-66
29568712-9 2018 Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. Uric Acid 54-56 insulin Homo sapiens 90-97
29233733-11 2018 Dioscin"s metabolite Tigogenin significantly inhibited uric acid re-absorption via URAT1 from 10 to 100muM. Uric Acid 55-64 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 83-88
29233733-12 2018 Diosgenin and Tigogenin increased uric acid excretion via ATP binding cassette subfamily G member 2 (ABCG2). Uric Acid 34-43 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 58-99
29233733-12 2018 Diosgenin and Tigogenin increased uric acid excretion via ATP binding cassette subfamily G member 2 (ABCG2). Uric Acid 34-43 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 101-106
29031886-2 2018 Here, highly sensitive sensors for simultaneous detection of glucose and uric acid are successfully constructed based on solution-gated graphene transistors (SGGTs) with two separate Au gate electrodes, modified with GOx-CHIT and BSA-CHIT respectively. Uric Acid 73-82 hydroxyacid oxidase 1 Homo sapiens 217-220
29544526-9 2018 RESULTS: Significantly increased paw swelling and index and ankle joint swelling were observed in miR-146a KO mice compared to WT controls after MSU treatment. Uric Acid 145-148 microRNA 146 Mus musculus 98-106
29132945-8 2018 After adjustment for demographic, cardiovascular, and kidney-specific covariates, higher uric acid concentrations were independently associated with risk for kidney failure in participants with estimated glomerular filtration rates (eGFRs) >= 45mL/min/1.73m2 (adjusted HR per 1-standard deviation greater baseline uric acid, 1.40; 95% CI, 1.12-1.75), but not in those with eGFRs<30mL/min/1.73m2. Uric Acid 89-98 CD59 molecule (CD59 blood group) Homo sapiens 251-256
29132945-8 2018 After adjustment for demographic, cardiovascular, and kidney-specific covariates, higher uric acid concentrations were independently associated with risk for kidney failure in participants with estimated glomerular filtration rates (eGFRs) >= 45mL/min/1.73m2 (adjusted HR per 1-standard deviation greater baseline uric acid, 1.40; 95% CI, 1.12-1.75), but not in those with eGFRs<30mL/min/1.73m2. Uric Acid 89-98 CD59 molecule (CD59 blood group) Homo sapiens 390-395
29359786-0 2018 Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells. Uric Acid 0-9 adiponectin, C1Q and collagen domain containing Rattus norvegicus 26-37
29358459-9 2018 Subjects with insulin values >=15 U/L showed significant higher values of office systolic blood pressure, triglycerides, and uric acid and lower values of high-density lipoprotein than did those with normal insulin values. Uric Acid 128-137 insulin Homo sapiens 14-21
29258826-4 2018 We have developed an assay for myeloperoxidase activity that includes its major physiological substrates - chloride, thiocyanate, tyrosine, and urate. Uric Acid 144-149 myeloperoxidase Homo sapiens 31-46
29459295-0 2018 The link between insulin resistance parameters and serum uric acid is mediated by adiposity. Uric Acid 57-66 insulin Homo sapiens 17-24
29094330-10 2018 In a multivariate model adjusted for age, BMI, diabetes, hypertension, alcohol drinking, SBP, total cholesterol, and eGFR, the odds ratio for rapid decline of renal function increased across quartiles of serum uric acid level, reaching a 1.32 (95% CI 1.02-2.97) for the top quartile compared to the lowest quartile (P for trend < 0.001). Uric Acid 210-219 selenium binding protein 1 Homo sapiens 89-92
29359786-0 2018 Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells. Uric Acid 0-9 adiponectin, C1Q and collagen domain containing Rattus norvegicus 38-49
29359786-3 2018 Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. Uric Acid 97-106 adiponectin, C1Q and collagen domain containing Rattus norvegicus 141-144
29359786-3 2018 Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. Uric Acid 97-106 adiponectin, C1Q and collagen domain containing Rattus norvegicus 149-152
29359786-3 2018 Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. Uric Acid 97-106 adiponectin receptor 1 Homo sapiens 165-172
29415757-0 2018 Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 8-17 PDZ domain containing 1 Homo sapiens 28-33
29512627-10 2018 A high UA level was associated with a higher HCM Risk-SCD score, positive fQRS, higher galectin-3 level, greater LAAPD, VT incidence, and the need for ICD implantation and CPR in patients with HCM. Uric Acid 7-9 galectin 3 Homo sapiens 87-97
29482609-4 2018 This study was conducted to evaluate the function of miR-302b on monosodium urate (MSU) crystal-induced inflammation and its mechanism. Uric Acid 65-81 microRNA 302b Homo sapiens 53-61
29482609-4 2018 This study was conducted to evaluate the function of miR-302b on monosodium urate (MSU) crystal-induced inflammation and its mechanism. Uric Acid 83-86 microRNA 302b Homo sapiens 53-61
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 32-48 xanthine dehydrogenase Mus musculus 166-182
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 32-48 xanthine dehydrogenase Mus musculus 184-186
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 50-53 NLR family, pyrin domain containing 3 Mus musculus 78-83
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 50-53 xanthine dehydrogenase Mus musculus 166-182
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 50-53 xanthine dehydrogenase Mus musculus 184-186
29433540-0 2018 Response to: "Monosodium urate crystal deposition associated with the progress of radiographic grade at the sacroiliac joint in axial SpA: a dual-energy CT study". Uric Acid 14-30 surfactant protein A2 Homo sapiens 134-137
29488355-4 2018 The model was qualified for prediction of the effect of patients" GFR and FE on concentration of UA in serum (sUA) and UA excretion in urine and their response to drug treatment, using data from 2 Phase I and 4 Phase III studies of lesinurad. Uric Acid 97-99 Rap guanine nucleotide exchange factor 5 Homo sapiens 66-69
29279328-1 2018 A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Uric Acid 32-48 NLR family, pyrin domain containing 3 Mus musculus 78-83
29415757-0 2018 Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 8-17 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 38-43
29415757-0 2018 Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 8-17 toll like receptor 4 Homo sapiens 94-98
29415757-0 2018 Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 99-104
29415757-10 2018 RESULTS: Soluble uric acid increased the expression of PDZK1 and ABCG2. Uric Acid 17-26 PDZ domain containing 1 Homo sapiens 55-60
29415757-10 2018 RESULTS: Soluble uric acid increased the expression of PDZK1 and ABCG2. Uric Acid 17-26 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 65-70
29415757-11 2018 The stimulation of soluble uric acid also facilitated the translocation of ABCG2 from the intracellular compartment to the plasma membrane and increased its transport activity. Uric Acid 27-36 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 75-80
29415757-12 2018 Moreover, the upregulation of PDZK1 and ABCG2 by soluble uric acid was partially decreased by either TLR4-NLRP3 inflammasome inhibitors or PI3K/Akt signaling inhibitors. Uric Acid 57-66 PDZ domain containing 1 Homo sapiens 30-35
29415757-12 2018 Moreover, the upregulation of PDZK1 and ABCG2 by soluble uric acid was partially decreased by either TLR4-NLRP3 inflammasome inhibitors or PI3K/Akt signaling inhibitors. Uric Acid 57-66 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 40-45
29415757-12 2018 Moreover, the upregulation of PDZK1 and ABCG2 by soluble uric acid was partially decreased by either TLR4-NLRP3 inflammasome inhibitors or PI3K/Akt signaling inhibitors. Uric Acid 57-66 toll like receptor 4 Homo sapiens 101-105
29415757-12 2018 Moreover, the upregulation of PDZK1 and ABCG2 by soluble uric acid was partially decreased by either TLR4-NLRP3 inflammasome inhibitors or PI3K/Akt signaling inhibitors. Uric Acid 57-66 NLR family pyrin domain containing 3 Homo sapiens 106-111
29415757-13 2018 Furthermore, PDZK1 knockdown significantly inhibited the expression and transport activity of ABCG2 regardless of the activation by soluble uric acid, demonstrating a pivotal role for PDZK1 in the regulation of ABCG2. Uric Acid 140-149 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 94-99
29415757-13 2018 Furthermore, PDZK1 knockdown significantly inhibited the expression and transport activity of ABCG2 regardless of the activation by soluble uric acid, demonstrating a pivotal role for PDZK1 in the regulation of ABCG2. Uric Acid 140-149 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 211-216
29285924-6 2018 Experiments demonstrated the 10-8 M level detection sensitivity to H2O2 as well as to glucose or uric acid if presubjected to glucose oxidase or uricase. Uric Acid 97-106 urate oxidase Rattus norvegicus 145-152
29415757-14 2018 CONCLUSIONS: These findings suggest that urate upregulates the expression of PDZK1 and ABCG2 for excretion in intestinal cells via activating the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 41-46 PDZ domain containing 1 Homo sapiens 77-82
29415757-14 2018 CONCLUSIONS: These findings suggest that urate upregulates the expression of PDZK1 and ABCG2 for excretion in intestinal cells via activating the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 41-46 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 87-92
29415757-14 2018 CONCLUSIONS: These findings suggest that urate upregulates the expression of PDZK1 and ABCG2 for excretion in intestinal cells via activating the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 41-46 toll like receptor 4 Homo sapiens 146-150
29415757-14 2018 CONCLUSIONS: These findings suggest that urate upregulates the expression of PDZK1 and ABCG2 for excretion in intestinal cells via activating the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 41-46 NLR family pyrin domain containing 3 Homo sapiens 151-156
29342419-3 2018 A recent genome wide association study suggested that allopurinol, a serum uric acid-lowering drug that inhibits xanthine dehydrogenase, is a potent substrate of ABCG2. Uric Acid 75-84 xanthine dehydrogenase Homo sapiens 113-135
28961526-4 2018 This phenomenon was used to develop a fluorescent method for facile detection of uric acid within a linear range of 0.1-100muM and 100-500muM, with a detection limit of 0.05muM (S/N=3). Uric Acid 81-90 latexin Homo sapiens 123-126
28961526-4 2018 This phenomenon was used to develop a fluorescent method for facile detection of uric acid within a linear range of 0.1-100muM and 100-500muM, with a detection limit of 0.05muM (S/N=3). Uric Acid 81-90 latexin Homo sapiens 138-141
28846182-0 2018 Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials. Uric Acid 71-80 solute carrier family 5 member 2 Homo sapiens 11-42
28846182-0 2018 Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials. Uric Acid 71-80 solute carrier family 5 member 2 Homo sapiens 44-49
28846182-1 2018 The aim of this study was to describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 113-122 solute carrier family 5 member 2 Homo sapiens 53-84
28846182-1 2018 The aim of this study was to describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 113-122 solute carrier family 5 member 2 Homo sapiens 86-91
28928085-1 2018 Genome wide association studies revealed single nucleotide polymorphisms (SNP) located within the promoter of PDZ domain containing protein 1 (PDZK1) to be associated with serum uric acid levels. Uric Acid 178-187 PDZ domain containing 1 Homo sapiens 143-148
28928085-2 2018 Since modulation of transporters and particularly of membrane proteins involved in uric acid handling by PDZK1 has previously been reported, the aim of this study was to analyze the impact of the polymorphisms rs1967017, rs1471633, and rs12129861 on promoter activity and thereby transcription of PDZK1. Uric Acid 83-92 PDZ domain containing 1 Homo sapiens 105-110
28928085-5 2018 Furthermore, our study shows regulation of PDZK1 by thyroid hormones, thereby providing a mechanistic basis for the previously reported associations between thyroid hormone status and uric acid homeostasis. Uric Acid 184-193 PDZ domain containing 1 Homo sapiens 43-48
29342419-3 2018 A recent genome wide association study suggested that allopurinol, a serum uric acid-lowering drug that inhibits xanthine dehydrogenase, is a potent substrate of ABCG2. Uric Acid 75-84 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 162-167
29264928-5 2018 Areas covered: ABCG2 regulates serum uric acid via physiologically important roles in both renal and extra-renal urate excretion. Uric Acid 37-46 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 15-20
29264928-5 2018 Areas covered: ABCG2 regulates serum uric acid via physiologically important roles in both renal and extra-renal urate excretion. Uric Acid 113-118 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 15-20
29264928-10 2018 Manipulation of ABCG2, including controlling the level and location of its expression, has the potential to prevent gout by promoting uric acid excretion as effectively as general uricosuric drugs. Uric Acid 134-143 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 16-21
29507690-9 2018 Results: Incubation with a high-level uric acid medium (10 mg/dL) significantly suppressed EPC proliferation, reduced NO production, and lessened phosphorylation of Akt and eNOS. Uric Acid 38-47 thymoma viral proto-oncogene 1 Mus musculus 165-168
29789791-0 2018 Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study. Uric Acid 53-62 insulin like growth factor 1 Homo sapiens 20-48
29789791-1 2018 Objective: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Uric Acid 120-129 insulin like growth factor 1 Homo sapiens 73-101
29789791-1 2018 Objective: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Uric Acid 120-129 insulin like growth factor 1 Homo sapiens 103-108
29789791-1 2018 Objective: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Uric Acid 131-133 insulin like growth factor 1 Homo sapiens 73-101
29789791-1 2018 Objective: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Uric Acid 131-133 insulin like growth factor 1 Homo sapiens 103-108
29789791-5 2018 Results: A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P = 0.004). Uric Acid 98-100 insulin like growth factor 1 Homo sapiens 84-89
29789791-6 2018 In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 mumol/L and 301 mumol/L (beta 0.010, 95% CI 0.004-0.017; P = 0.002). Uric Acid 101-103 insulin like growth factor 1 Homo sapiens 59-64
29789791-6 2018 In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 mumol/L and 301 mumol/L (beta 0.010, 95% CI 0.004-0.017; P = 0.002). Uric Acid 109-111 insulin like growth factor 1 Homo sapiens 59-64
29789791-7 2018 The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 mumol/L (beta -0.055, 95% CI -0.081--0.028; P < 0.001) or more than 301 mumol/L (beta -0.005, 95% CI -0.013-0.002; P = 0.174). Uric Acid 56-58 insulin like growth factor 1 Homo sapiens 14-19
29789791-7 2018 The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 mumol/L (beta -0.055, 95% CI -0.081--0.028; P < 0.001) or more than 301 mumol/L (beta -0.005, 95% CI -0.013-0.002; P = 0.174). Uric Acid 64-66 insulin like growth factor 1 Homo sapiens 14-19
29789791-8 2018 Conclusions: This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. Uric Acid 80-82 insulin like growth factor 1 Homo sapiens 70-75
29789791-9 2018 This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect. Uric Acid 56-58 insulin like growth factor 1 Homo sapiens 89-94
28808841-12 2018 MEE and MEf have significantly negative correlation with troponin I, BNP, uric acid and positive correlation with epicardial fat thickness. Uric Acid 74-83 E74 like ETS transcription factor 4 Homo sapiens 8-11
29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Uric Acid 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124
29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Uric Acid 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130
29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. Uric Acid 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145
29406992-6 2018 Uric acid has been found to be the most potent inhibitor of AChE, with a binding affinity higher than the known inhibitors of the enzyme. Uric Acid 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64
29434538-0 2018 Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson"s Disease Models. Uric Acid 15-20 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-5
29434538-7 2018 These results suggested that Glut9 was a functional urate transporter, whose up-regulation by activation of p53 resulted in the increased intracellular urate levels in PD models. Uric Acid 52-57 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 29-34
29434538-7 2018 These results suggested that Glut9 was a functional urate transporter, whose up-regulation by activation of p53 resulted in the increased intracellular urate levels in PD models. Uric Acid 52-57 transformation related protein 53, pseudogene Mus musculus 108-111
29434538-8 2018 Our findings suggest that Glut9 could be modified to modulate urate levels in dopaminergic neurons and urate-elevating strategies without increasing systemic levels to avoid side effects might serve as a potential therapeutic target for PD. Uric Acid 62-67 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 26-31
29093325-5 2018 These findings demonstrated that 3,5,2",4"-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism. Uric Acid 75-84 xanthine dehydrogenase Mus musculus 135-138
29149990-7 2018 The limits of detection and the linear ranges, respectively, were 15.7 mg L-1 and 50-600 mg L-1 for CRN and 16.5 mg L-1 and 50-500 mg L-1 for UA. Uric Acid 142-144 immunoglobulin kappa variable 1-16 Homo sapiens 116-137
30110674-1 2018 BACKGROUND: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. Uric Acid 30-39 IGAN1 Homo sapiens 104-108
30110674-5 2018 After adjustment for demographic and IgAN specific covariates and treatments, a higher quartile of uric acid was linearly associated with an increased risk of the primary outcome (highest versus lowest quartile, hazard ratio [HR] 2.39; 95% CI 1.52-3.75) and kidney failure (highest versus lowest quartile, HR 2.55; 95% CI 1.62-4.01) in the Cox proportional hazards regression models. Uric Acid 99-108 IGAN1 Homo sapiens 37-41
30391956-5 2018 In addition, to replicate the human situation, uricase was inhibited (oxonic acid [OA] 750 mg/K/d) to increase uric acid (UA) levels. Uric Acid 111-120 urate oxidase (pseudogene) Homo sapiens 47-54
30391956-5 2018 In addition, to replicate the human situation, uricase was inhibited (oxonic acid [OA] 750 mg/K/d) to increase uric acid (UA) levels. Uric Acid 122-124 urate oxidase (pseudogene) Homo sapiens 47-54
29093325-5 2018 These findings demonstrated that 3,5,2",4"-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism. Uric Acid 75-84 phosphoribosyl pyrophosphate amidotransferase Mus musculus 146-152
29093325-5 2018 These findings demonstrated that 3,5,2",4"-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism. Uric Acid 75-84 hypoxanthine guanine phosphoribosyl transferase Mus musculus 157-162
29924138-3 2018 In this study, we found a significant increase in plasma uric acid (P=0.002) and allantoin (P=0.025) in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) that presented common carotid intima-media thickness (c-IMT) within the 75th percentile (c-IMT>=P75). Uric Acid 57-66 CIMT Homo sapiens 237-242
29924138-3 2018 In this study, we found a significant increase in plasma uric acid (P=0.002) and allantoin (P=0.025) in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) that presented common carotid intima-media thickness (c-IMT) within the 75th percentile (c-IMT>=P75). Uric Acid 57-66 CIMT Homo sapiens 272-277
29924138-4 2018 Multiple linear regression showed an association of c-IMT with uric acid (beta=0.0004, P=0.014) and allantoin (beta=0.018, P=0.008). Uric Acid 63-72 CIMT Homo sapiens 52-57
29393133-6 2018 Pilot studies in humans have reported a potential benefit of lowering serum uric acid on insulin resistance. Uric Acid 76-85 insulin Homo sapiens 89-96
29412122-5 2018 RESULTS: The administration of SGLT-2 inhibitors was observed to exert beneficial effects on a wide cluster of risk factors of chronic kidney disease, such as hyperglycemia, blood pressure, serum uric acid, and body weight. Uric Acid 196-205 solute carrier family 5 member 2 Homo sapiens 31-37
29533935-0 2018 Uric Acid Induces Cardiomyocyte Apoptosis via Activation of Calpain-1 and Endoplasmic Reticulum Stress. Uric Acid 0-9 calpain 1 Rattus norvegicus 60-69
29533935-3 2018 The aim of this current study was to test the effects of uric acid (UA) on cardiomyocyte survival and cardiac function and to investigate the role of calpain-1 in the UA-induced effects in the heart and their underlying mechanisms. Uric Acid 167-169 calpain 1 Rattus norvegicus 150-159
29533935-12 2018 Increased activation of calpain-1 and ER stress was also observed in the groups with high UA levels. Uric Acid 90-92 calpain 1 Rattus norvegicus 24-33
29533935-13 2018 Calpain-1 siRNA and the calpain inhibitor CI-III alleviated UA-induced ER stress and apoptosis, while inhibiting ER stress by tauroursodeoxycholic acid (TUDCA) mitigated UA-induced apoptosis without affecting calpain-1 expression or activity. Uric Acid 60-62 calpain 1 Rattus norvegicus 0-9
29533935-13 2018 Calpain-1 siRNA and the calpain inhibitor CI-III alleviated UA-induced ER stress and apoptosis, while inhibiting ER stress by tauroursodeoxycholic acid (TUDCA) mitigated UA-induced apoptosis without affecting calpain-1 expression or activity. Uric Acid 170-172 calpain 1 Rattus norvegicus 0-9
29533935-14 2018 CONCLUSIONS: These findings suggest that UA induces cardiomyocyte apoptosis through activation of calpain-1 and ER stress. Uric Acid 41-43 calpain 1 Rattus norvegicus 98-107
29843128-11 2018 Activation of Caspase-3 and phosphorylation of AMPK and ERK were enhanced by uric acid, and the enhancements were reversed by Zurampic. Uric Acid 77-86 caspase 3 Rattus norvegicus 14-23
29843128-11 2018 Activation of Caspase-3 and phosphorylation of AMPK and ERK were enhanced by uric acid, and the enhancements were reversed by Zurampic. Uric Acid 77-86 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 47-51
29843128-11 2018 Activation of Caspase-3 and phosphorylation of AMPK and ERK were enhanced by uric acid, and the enhancements were reversed by Zurampic. Uric Acid 77-86 Eph receptor B1 Rattus norvegicus 56-59
29444507-0 2018 High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress. Uric Acid 5-14 mitogen-activated protein kinase 1 Mus musculus 60-63
29444507-0 2018 High Uric Acid Inhibits Cardiomyocyte Viability Through the ERK/P38 Pathway via Oxidative Stress. Uric Acid 5-14 mitogen-activated protein kinase 14 Mus musculus 64-67
29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 70-86 NLR family pyrin domain containing 3 Homo sapiens 4-9
29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 70-86 interleukin 1 beta Homo sapiens 28-35
29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 88-91 NLR family pyrin domain containing 3 Homo sapiens 4-9
29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 88-91 interleukin 1 beta Homo sapiens 28-35
29393109-5 2018 UA increased the expression of snail and slug, the transcriptional repressors of E-cadherin, which resulted in a downregulation of E-cadherin production. Uric Acid 0-2 cadherin 1 Rattus norvegicus 81-91
29393109-5 2018 UA increased the expression of snail and slug, the transcriptional repressors of E-cadherin, which resulted in a downregulation of E-cadherin production. Uric Acid 0-2 cadherin 1 Rattus norvegicus 131-141
29393109-6 2018 UA also increased the degradation of E-cadherin via ubiquitination. Uric Acid 0-2 cadherin 1 Rattus norvegicus 37-47
29645064-6 2018 RESULTS: Adiponectin mRNA in VAT was significantly higher in obese insulin-sensitive patients than in the rest of obese patients (p < 0.05) and negatively correlated with HOMA-IR (r =-0.354, p=0.016) and uric acid (r =-0.304, p=0.045). Uric Acid 207-216 adiponectin, C1Q and collagen domain containing Homo sapiens 9-20
29393121-9 2018 The intestinal ABCG2 may play a compensatory role in light of decreased renal clearance of UA in CKD model rats, the trigger of which is not a uremic toxin but serum UA itself. Uric Acid 91-93 ATP binding cassette subfamily G member 2 Rattus norvegicus 15-20
29393121-9 2018 The intestinal ABCG2 may play a compensatory role in light of decreased renal clearance of UA in CKD model rats, the trigger of which is not a uremic toxin but serum UA itself. Uric Acid 166-168 ATP binding cassette subfamily G member 2 Rattus norvegicus 15-20
29393127-8 2018 Many transport proteins are candidate participants in urate handling, with URAT1 and GLUT9 being the best characterized to date. Uric Acid 54-59 solute carrier family 22 member 12 Homo sapiens 75-80
29393127-8 2018 Many transport proteins are candidate participants in urate handling, with URAT1 and GLUT9 being the best characterized to date. Uric Acid 54-59 solute carrier family 2 member 9 Homo sapiens 85-90
29393133-2 2018 For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome. Uric Acid 113-122 insulin Homo sapiens 63-70
29393133-5 2018 The mechanism for uric acid-induced insulin resistance appears to be mediated by the development of mitochondrial oxidative stress and impairment of insulin-dependent stimulation of nitric oxide in endothelial cells. Uric Acid 18-27 insulin Homo sapiens 36-43
29525370-13 2018 UA was a predictor of cardiovascular mortality in the univariate analysis (HR1mg/dL = 1.30; p=0.002), but not in a multivariate analysis adjusted for urinary albumin excretion and eGFR (HR1mg/dL=1.20; p=0.12). Uric Acid 0-2 epidermal growth factor receptor Homo sapiens 180-184
29651957-1 2018 INTRODUCTION: Chronic serum uric acid elevation (SUA) is known to be induced by dyslipidemia, hypertension, inflammation, and insulin resistance. Uric Acid 28-37 insulin Homo sapiens 126-133
29437024-3 2018 RESULTS: Uric acid levels were positively related to male gender, waist circumference, BMI, systolic and diastolic pressure levels, fasting insulin, fasting glucose, HOMA-IR, triglycerides, total cholesterol, LDL cholesterol, the presence of metabolic syndrome and the number of the components of metabolic syndrome and negatively related to HDL cholesterol levels. Uric Acid 9-18 insulin Gallus gallus 140-147
29645064-8 2018 CONCLUSIONS: In severely obese patients, adiponectin gene expression in VAT is negatively correlated with serum levels of uric acid and is an independent determinant, together with anthropometric parameters of visceral obesity and serum adiponectin levels, of insulin resistance. Uric Acid 122-131 adiponectin, C1Q and collagen domain containing Homo sapiens 41-52
29247992-3 2018 The NLRP3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. Uric Acid 78-87 NLR family pyrin domain containing 3 Homo sapiens 4-9
29080939-2 2018 A recent meta-analysis of genome-wide association studies has newly identified the relationship between serum uric acid (SUA) levels and rs889472, a single nucleotide polymorphism of musculoaponeurotic fibrosarcoma oncogene (MAF/c-MAF). Uric Acid 110-119 MAF bZIP transcription factor Homo sapiens 225-228
29080939-2 2018 A recent meta-analysis of genome-wide association studies has newly identified the relationship between serum uric acid (SUA) levels and rs889472, a single nucleotide polymorphism of musculoaponeurotic fibrosarcoma oncogene (MAF/c-MAF). Uric Acid 110-119 MAF bZIP transcription factor Homo sapiens 229-234
28729031-1 2018 The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. Uric Acid 79-88 urate oxidase Mus musculus 4-17
30076706-2 2018 SGLT2 inhibitors represent a new category of oral antidiabetic agents that can also reduce systolic and diastolic blood pressure, as well as serum uric acid, and improve the glomerular filtration rate. Uric Acid 147-156 solute carrier family 5 member 2 Homo sapiens 0-5
29215084-7 2018 Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout. Uric Acid 67-76 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 93-98
29215084-7 2018 Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout. Uric Acid 67-76 solute carrier family 2 member 9 Homo sapiens 100-106
29215084-7 2018 Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout. Uric Acid 67-76 solute carrier family 22 member 12 Homo sapiens 112-120
29057475-7 2018 The EF may lower the uric acid level through inhibiting the expression of URAT1 mRNA and enhancing the expression of OAT3 mRNA. Uric Acid 21-30 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 74-79
29057475-7 2018 The EF may lower the uric acid level through inhibiting the expression of URAT1 mRNA and enhancing the expression of OAT3 mRNA. Uric Acid 21-30 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 117-121
30244943-7 2018 RESULTS: Using proteomics and selective precipitation methods, we identified major antioxidative contributions for fibrinogen, immunoglobulin G, albumin, and small soluble molecules like uric acid and ascorbate, with albumin being especially dominant in copper-initiated mechanisms. Uric Acid 187-196 albumin Homo sapiens 217-224
28747144-4 2018 The ATP-binding cassette transporter, ABCG2, is a uric acid (UA) transporter that effluxes UA from cells in the CNS and is responsible for systemic UA clearance. Uric Acid 61-63 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 38-43
28747144-4 2018 The ATP-binding cassette transporter, ABCG2, is a uric acid (UA) transporter that effluxes UA from cells in the CNS and is responsible for systemic UA clearance. Uric Acid 91-93 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 38-43
30763014-8 2018 Independent predictors of insulin resistance and premature carotid atherosclerosis in patients with multifocal fatty liver disease were: serum gamma-glutamyl transferase (odds ratio 1.69), high-sensitivity C-reactive protein (odds ratio 1.62), uric acid (odds ratio 1.55), very low-density lipoprotein (odds ratio 1.74), total cholesterol/high-density lipoprotein (odds ratio 1.58) and severity of liver stiffness measured by Fibroscan (odds ratio 1.9). Uric Acid 244-253 insulin Homo sapiens 26-33
30763014-17 2018 Independent predictors of insulin resistance and premature carotid atherosclerosis in patients with multifocal fatty liver disease were: serum gamma-glutamyl transferase (odds ratio 1.69), high-sensitivity C-reactive protein (odds ratio 1.62), uric acid (odds ratio 1.55), very low-density lipoprotein (odds ratio 1.74), total cholesterol/high-density lipoprotein (odds ratio 1.58) and severity of liver stiffness measured by Fibroscan (odds ratio 1.9). Uric Acid 244-253 insulin Homo sapiens 26-33
28729031-1 2018 The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. Uric Acid 79-88 urate oxidase Mus musculus 19-22
28729031-1 2018 The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. Uric Acid 79-88 urate oxidase Mus musculus 37-44
29218516-4 2018 Finally, we also describe how GLUT9-expressing oocytes can be used to measure urate kinetics by radioisotopes as well as two-microelectrode voltage clamping techniques. Uric Acid 78-83 solute carrier family 2 (facilitated glucose transporter), member 6 L homeolog Xenopus laevis 30-35
30099444-15 2018 CONCLUSION: We found that in patients with CKD, urinary sodium and potassium excretion is closely correlated to renal handling of uric acid, which was pronounced in hypertensive patients with low eGFR. Uric Acid 130-139 epidermal growth factor receptor Homo sapiens 196-200
29689561-2 2018 Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, such as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. Uric Acid 81-86 angiotensin I converting enzyme Homo sapiens 267-270
29689561-2 2018 Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, such as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. Uric Acid 182-191 angiotensin I converting enzyme Homo sapiens 267-270
29226668-10 2017 However, it is still able to detect DA down to 1 pM range in the presence of [AA] = 100 muM and 100 pM in the presence of [UA] = 3 muM, these values for AA and UA being the physiological levels in the cerebrospinal fluid and the striatum, respectively. Uric Acid 123-125 latexin Homo sapiens 131-134
29101234-6 2017 This time-dependent suppression of PPARalpha-mediated transactivation by bile acids caused an oscillation in the hepatic expression of XOD, which, in turn, led to circadian alterations in uric acid production. Uric Acid 188-197 peroxisome proliferator activated receptor alpha Mus musculus 35-44
29101234-6 2017 This time-dependent suppression of PPARalpha-mediated transactivation by bile acids caused an oscillation in the hepatic expression of XOD, which, in turn, led to circadian alterations in uric acid production. Uric Acid 188-197 xanthine dehydrogenase Mus musculus 135-138
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 110-115 autophagy related 5 Homo sapiens 37-41
29267361-11 2017 The level of uric acid in the initial intestinal tissue was very high, where XDH and most of the proteins associated with bicarbonate secretion were up-regulated. Uric Acid 13-22 xanthine dehydrogenase Rattus norvegicus 77-80
29101234-0 2017 Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARalpha. Uric Acid 63-72 xanthine dehydrogenase Mus musculus 91-107
29101234-0 2017 Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARalpha. Uric Acid 63-72 peroxisome proliferator activated receptor alpha Mus musculus 139-148
29101234-1 2017 Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric Acid 137-146 xanthine dehydrogenase Mus musculus 0-16
29101234-1 2017 Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric Acid 137-146 xanthine dehydrogenase Mus musculus 18-21
29101234-1 2017 Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric Acid 137-146 xanthine dehydrogenase Mus musculus 38-60
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 110-115 beclin 1 Homo sapiens 46-53
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 110-115 interleukin 1 beta Homo sapiens 90-98
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 110-115 NLR family pyrin domain containing 3 Homo sapiens 160-165
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 115-131 autophagy related 5 Homo sapiens 37-41
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 115-131 beclin 1 Homo sapiens 46-53
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 115-131 interleukin 1 beta Homo sapiens 90-98
29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 115-131 NLR family pyrin domain containing 3 Homo sapiens 160-165
28986252-0 2017 Uric acid demonstrates neuroprotective effect on Parkinson"s disease mice through Nrf2-ARE signaling pathway. Uric Acid 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 82-86
29594655-0 2017 Uricase based fluorometric determination of uric acid based on the use of graphene quantum dot@silver core-shell nanocomposites. Uric Acid 44-53 urate oxidase (pseudogene) Homo sapiens 0-7
29594655-3 2017 However, if the silver shell was removed via etching with H2O2 (which is produced by uricase catalyzed oxidation of UA), the fluorescence of the GQDs is restored. Uric Acid 116-118 urate oxidase (pseudogene) Homo sapiens 85-92
29594655-10 2017 Uricase catalyzes the oxidation of uric acid (UA) to produce allantoin and H2O2 which etches the silver shell. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 0-7
29594655-10 2017 Uricase catalyzes the oxidation of uric acid (UA) to produce allantoin and H2O2 which etches the silver shell. Uric Acid 46-48 urate oxidase (pseudogene) Homo sapiens 0-7
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 interleukin 1 alpha Mus musculus 50-58
28986252-2 2017 Our previous study has shown that uric acid protected dopaminergic cell line damage through inhibiting accumulation of NF-E2-related factor 2 (Nrf2). Uric Acid 34-43 nuclear factor, erythroid derived 2, like 2 Mus musculus 119-141
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 interleukin 1 beta Mus musculus 105-122
28986252-2 2017 Our previous study has shown that uric acid protected dopaminergic cell line damage through inhibiting accumulation of NF-E2-related factor 2 (Nrf2). Uric Acid 34-43 nuclear factor, erythroid derived 2, like 2 Mus musculus 143-147
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 interleukin 1 alpha Mus musculus 124-132
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 interleukin 6 Mus musculus 135-139
28986252-5 2017 Mice were treated with either uric acid (intraperitoneally injection 250 mg/kg) or saline for a total of 13 d. We showed that uric acid improved behavioral performances and cognition of PD mice, increased TH-positive dopaminergic neurons and decreased GFAP-positive astrocytes in substantia nigra (SN). Uric Acid 30-39 glial fibrillary acidic protein Mus musculus 252-256
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 tumor necrosis factor Mus musculus 144-171
28986252-8 2017 Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Uric Acid 0-9 tumor necrosis factor Mus musculus 173-182
28986252-5 2017 Mice were treated with either uric acid (intraperitoneally injection 250 mg/kg) or saline for a total of 13 d. We showed that uric acid improved behavioral performances and cognition of PD mice, increased TH-positive dopaminergic neurons and decreased GFAP-positive astrocytes in substantia nigra (SN). Uric Acid 126-135 glial fibrillary acidic protein Mus musculus 252-256
28986252-6 2017 Uric acid increased mRNA and protein expressions of Nrf2 and three Nrf2-responsive genes, including gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC), heme oxygenase-1 (HO-1) and NQO1. Uric Acid 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 52-56
28986252-6 2017 Uric acid increased mRNA and protein expressions of Nrf2 and three Nrf2-responsive genes, including gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC), heme oxygenase-1 (HO-1) and NQO1. Uric Acid 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 67-71
28986252-6 2017 Uric acid increased mRNA and protein expressions of Nrf2 and three Nrf2-responsive genes, including gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC), heme oxygenase-1 (HO-1) and NQO1. Uric Acid 0-9 heme oxygenase 1 Mus musculus 164-180
28986252-6 2017 Uric acid increased mRNA and protein expressions of Nrf2 and three Nrf2-responsive genes, including gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC), heme oxygenase-1 (HO-1) and NQO1. Uric Acid 0-9 heme oxygenase 1 Mus musculus 182-186
28986252-6 2017 Uric acid increased mRNA and protein expressions of Nrf2 and three Nrf2-responsive genes, including gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC), heme oxygenase-1 (HO-1) and NQO1. Uric Acid 0-9 NAD(P)H dehydrogenase, quinone 1 Mus musculus 192-196
28986252-7 2017 Uric acid significantly increased superoxide dismutase (SOD), CAT, glutathione (GSH) levels and decreased malondialdehyde (MDA) level in SN regions of MPTP-treated mice. Uric Acid 0-9 catalase Mus musculus 62-65
28839105-3 2017 Alcohol consumption increases activity of the enzyme xanthine oxidoreductase (XOR) that contributes to production of both reactive oxygen species (ROS) and uric acid, a damage-associated molecular pattern. Uric Acid 156-165 xanthine dehydrogenase Homo sapiens 53-76
28839105-3 2017 Alcohol consumption increases activity of the enzyme xanthine oxidoreductase (XOR) that contributes to production of both reactive oxygen species (ROS) and uric acid, a damage-associated molecular pattern. Uric Acid 156-165 xanthine dehydrogenase Homo sapiens 78-81
28839105-10 2017 Our data suggest that AUDs augment pulmonary and systemic XOR activity that may contribute to ROS and uric acid generation, promoting inflammation. Uric Acid 102-111 xanthine dehydrogenase Homo sapiens 58-61
28977161-4 2017 A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Uric Acid 244-253 fibronectin type III domain containing 5 Homo sapiens 44-50
29045935-8 2017 More importantly, emodinol reversed dys-expression of organic ion transporters, inhibited NLRP3 inflammsome activation and suppressed TLRs/MyD88/NF-kappaB signaling pathway in the kidneys of urate nephropathy rats. Uric Acid 191-196 MYD88, innate immune signal transduction adaptor Rattus norvegicus 139-144
28805076-12 2017 Serum uric acid and NEFA linearly increased from low to high RFI in females, whereas in males, cholesterol showed the same linear response from low to high RFI. Uric Acid 6-15 RFI Gallus gallus 61-64
28805076-15 2017 Regression analysis showed significant positive relationships between RFI and serum uric acid (R2 = 0.49) and cholesterol (R2 = 0.13). Uric Acid 84-93 RFI Gallus gallus 70-73
28622913-7 2017 Laboratory evidence that urate confers neuroprotection in cellular and animal models of PD, possibly via the Nrf2 antioxidant response pathway, further strengthened its candidacy for rapid clinical translation. Uric Acid 25-30 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113
28853701-9 2017 Low eGFR, high serum uric acid, and small vessel hyalinosis increased risk of abnormal BP rhythm in IgAN patients. Uric Acid 21-30 IGAN1 Homo sapiens 100-104
28622913-8 2017 An early phase trial of the urate precursor inosine demonstrated its capacity to safely produce well tolerated, long-term elevation of plasma and CSF urate in early PD, supporting a phase 3 trial now underway to determine whether oral inosine dosed to elevate urate to concentrations predictive of favorable prognosis in PD slows clinical decline in people with recently diagnosed, dopamine transporter-deficient PD. Uric Acid 28-33 solute carrier family 6 member 3 Homo sapiens 382-402
28078916-9 2017 Acute toxicity studies of HNK-102 and 2-PAM showed sporadic changes in urea, uric acid, aspartate aminotransferase, and so on compared to control group, however, not supported by histopathological investigations. Uric Acid 77-86 peptidylglycine alpha-amidating monooxygenase Mus musculus 40-43
29103339-4 2017 Lesinurad is a URAT1 inhibitor that selectively inhibits urate rebsorption at the proximal renal tubule. Uric Acid 57-62 solute carrier family 22 member 12 Homo sapiens 15-20
28709376-4 2017 Specifically, the DPV showed a linear relationship between peak current and UA concentration in the range of 2.8 to 57.5 muM with the equation of I pa (muA) = 0.0121c UA (muM) + 0.3122 (R 2 = 0.9987). Uric Acid 76-78 latexin Homo sapiens 121-124
28709376-4 2017 Specifically, the DPV showed a linear relationship between peak current and UA concentration in the range of 2.8 to 57.5 muM with the equation of I pa (muA) = 0.0121c UA (muM) + 0.3122 (R 2 = 0.9987). Uric Acid 76-78 latexin Homo sapiens 171-174
29133805-0 2017 Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients. Uric Acid 58-67 xanthine dehydrogenase Homo sapiens 0-23
28819713-5 2017 Elevated plasma GDF-15 levels were positively related to Functional Class, uric acid, N-terminal pro-B-type natriuretic peptide (NT-proBNP), pulmonary artery systolic pressure, mean pulmonary artery pressure, pulmonary blood flow/systemic blood flow and pulmonary vascular resistance, and a lower mixed venous oxygen saturation (Svo2). Uric Acid 75-84 growth differentiation factor 15 Homo sapiens 16-22
29133805-3 2017 Plasma glucose and serum uric acid levels correlated significantly and positively with plasma XOR-a. Uric Acid 25-34 xanthine dehydrogenase Homo sapiens 94-97
29133805-5 2017 While serum uric acid correlated significantly and positively with plasma XOR-a in hemodialysis patients without T2DM, plasma glucose and serum glycated albumin, a new marker of glycemic control in diabetic hemodialysis patients, correlated significantly and positively with plasma XOR-a in those with T2DM. Uric Acid 12-21 xanthine dehydrogenase Homo sapiens 74-77
29133805-6 2017 Multivariate analyses in those with T2DM revealed that plasma glucose and serum glycated albumin were associated significantly and independently with plasma XOR-a, and that serum uric acid was associated significantly and independently with XOR-a in those without T2DM. Uric Acid 179-188 xanthine dehydrogenase Homo sapiens 241-244
29118366-7 2017 Finally, BOT-4-one appeared to be superior to other known NLRP3 alkylators in inhibiting the functionality of the NLRP3 inflammasome and its resulting anti-inflammatory activity was confirmed in vivo using a monosodium urate-induced peritonitis mouse model. Uric Acid 219-224 NLR family, pyrin domain containing 3 Mus musculus 114-119
29095953-9 2017 The mean differences in rate of decline in the estimated glomerular filtration rate (4.10 mL/min/1.73 m2 per year slower in uric acid-lowering therapy recipients, 95% CI, 1.86-6.35) and the standardized mean differences in the change in proteinuria or albuminuria (-0.23 units of standard deviation greater in uric acid-lowering therapy recipients; 95% CI, -0.43 to -0.04) were also statistically significant. Uric Acid 124-133 CD59 molecule (CD59 blood group) Homo sapiens 93-98
28946192-8 2017 In vivo, in the mice studies, CCl4 administration induced hepatotoxicity and nephrotoxicity by a significant rise in the levels of serum liver biomarkers (gamma glutamyl transferase, lactate dehydrogenase, and aminotransferases) and serum renal biomarkers (urea, creatinine, and uric acid). Uric Acid 279-288 chemokine (C-C motif) ligand 4 Mus musculus 30-34
28847893-5 2017 To predict prolongation, PlGF showed the highest incremental value (R2=0.72) on top of traditional predictors (gestational age at inclusion, diastolic blood pressure, proteinuria, creatinine, uric acid, alanine transaminase, lactate dehydrogenase, and platelets) compared with R2=0.53 for the traditional predictors only. Uric Acid 192-201 placental growth factor Homo sapiens 25-29
28332856-0 2017 Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females: A cross-sectional study. Uric Acid 63-72 gamma-glutamyltransferase 1 Homo sapiens 26-52
28332856-1 2017 OBJECTIVE: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females. Uric Acid 106-115 gamma-glutamyltransferase 1 Homo sapiens 56-82
28332856-1 2017 OBJECTIVE: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females. Uric Acid 106-115 gamma-glutamyltransferase 1 Homo sapiens 84-87
28821398-0 2017 Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy. Uric Acid 0-5 synuclein alpha Rattus norvegicus 15-19
28821398-0 2017 Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy. Uric Acid 0-5 synuclein alpha Rattus norvegicus 20-35
28821398-0 2017 Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy. Uric Acid 0-5 mechanistic target of rapamycin kinase Rattus norvegicus 61-65
28821398-6 2017 Co-treatment with 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), an mTOR activator, abolished the UA-induced LC3-II increase. Uric Acid 119-121 mechanistic target of rapamycin kinase Rattus norvegicus 89-93
28821398-8 2017 The in vivo study showed that UA administration was able to modulate the levels of autophagy markers, increase the autophagosome/autolysosome formation, and reduce SNCA accumulation in the midbrain of SNCAA53T transgenic mice. Uric Acid 30-32 synuclein, alpha Mus musculus 164-168
28821398-9 2017 Taken together, our findings suggest that UA could induce autophagy activation via an mTOR-dependent signaling and ameliorate SNCA accumulation. Uric Acid 42-44 mechanistic target of rapamycin kinase Rattus norvegicus 86-90
28821398-9 2017 Taken together, our findings suggest that UA could induce autophagy activation via an mTOR-dependent signaling and ameliorate SNCA accumulation. Uric Acid 42-44 synuclein alpha Rattus norvegicus 126-130
29104632-0 2017 Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy. Uric Acid 106-115 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 86-102
29058512-9 2017 Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Uric Acid 119-128 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 6-15
29132796-2 2017 In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Uric Acid 193-202 xanthine dehydrogenase Mus musculus 48-64
28690177-0 2017 Reply to: "Fructose, uric acid and zonal differences in NASH". Uric Acid 21-30 SAM domain, SH3 domain and nuclear localization signals 1 Homo sapiens 56-61
29132796-2 2017 In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Uric Acid 193-202 xanthine dehydrogenase Mus musculus 66-69
29175793-5 2017 Similarly negative effects of VDR BB genotype (p<0.01) and ALAD 1-2 genotype (p<0.05) were observed in the association of serum uric acid with BLL at the mean age >=30 years. Uric Acid 134-143 vitamin D receptor Homo sapiens 30-33
28901421-0 2017 Uric acid induces the expression of TNF-alpha via the ROS-MAPK-NF-kappaB signaling pathway in rat vascular smooth muscle cells. Uric Acid 0-9 tumor necrosis factor Rattus norvegicus 36-45
28901421-2 2017 In the present study, it was demonstrated that uric acid was capable of inducing the generation of TNF-alpha in vascular smooth muscle cells (VSMCs). Uric Acid 47-56 tumor necrosis factor Rattus norvegicus 99-108
28901421-5 2017 From the results, it was concluded that uric acid induced the expression of TNF-alpha in the VSMCs. Uric Acid 40-49 tumor necrosis factor Rattus norvegicus 76-85
28901421-6 2017 The antioxidant, N-acetylcysteine, eliminated the uric acid-induced expression of TNF-alpha. Uric Acid 50-59 tumor necrosis factor Rattus norvegicus 82-91
28901421-7 2017 In addition, uric acid increased the level of reactive oxygen species (ROS) and activated the phosphorylation of p38. Uric Acid 13-22 mitogen activated protein kinase 14 Rattus norvegicus 113-116
28901421-8 2017 Subsequent experiments confirmed that the p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, and nuclear factor (NF)-kappaB inhibitor, pyrrolidine dithiocarbamate, eliminated the uric acid-induced expression of TNF-alpha. Uric Acid 193-202 mitogen activated protein kinase 14 Rattus norvegicus 42-78
28901421-8 2017 Subsequent experiments confirmed that the p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, and nuclear factor (NF)-kappaB inhibitor, pyrrolidine dithiocarbamate, eliminated the uric acid-induced expression of TNF-alpha. Uric Acid 193-202 tumor necrosis factor Rattus norvegicus 225-234
28901421-9 2017 It was demonstrated that uric acid induced the expression of TNF-alpha via the ROS-MAPK-NF-kappaB signaling pathway in VSMCs, providing novel evidence supporting the pro-inflammatory and pro-atherosclerotic effects of uric acid. Uric Acid 25-34 tumor necrosis factor Rattus norvegicus 61-70
28901421-9 2017 It was demonstrated that uric acid induced the expression of TNF-alpha via the ROS-MAPK-NF-kappaB signaling pathway in VSMCs, providing novel evidence supporting the pro-inflammatory and pro-atherosclerotic effects of uric acid. Uric Acid 218-227 tumor necrosis factor Rattus norvegicus 61-70
29175793-5 2017 Similarly negative effects of VDR BB genotype (p<0.01) and ALAD 1-2 genotype (p<0.05) were observed in the association of serum uric acid with BLL at the mean age >=30 years. Uric Acid 134-143 aminolevulinate dehydratase Homo sapiens 62-66
29089036-0 2017 Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation. Uric Acid 0-9 endothelin 1 Mus musculus 70-82
29035321-3 2017 Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. Uric Acid 78-87 solute carrier family 22 member 12 Homo sapiens 6-25
29084343-12 2017 Kidney function may be improved by uric acid lowering therapy at one year with a reduction in serum creatinine (2 studies, 83 participants: MD -73.35 micromol/L, 95% CI -107.28 to -39.41) and a rise in eGFR (1 study, 113 participants: MD 5.50 mL/min/1.73 m2, 95% CI 0.59 to 10.41). Uric Acid 35-44 epidermal growth factor receptor Homo sapiens 202-206
29035321-3 2017 Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. Uric Acid 78-87 solute carrier family 22 member 12 Homo sapiens 27-32
29035321-6 2017 Immunization with the multi-epitope vaccine in streptozotocin-induced diabetes C57BL/6J mice successfully induced specific anti-URAT1 antibody, which inhibited URAT1 action and uric acid reabsorption, and increased pancreatic insulin level with a lower insulitis incidence. Uric Acid 177-186 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 128-133
29035321-7 2017 Vaccination with U-IA-2(5)-P2-1 (UIP-1) significantly reduced blood glucose and uric acid level, increased Th2 cytokines interleukin (IL)-10 and IL-4, and regulated immune reactions through a balanced Th1/Th2 ratio. Uric Acid 80-89 protein tyrosine phosphatase, receptor type, N Mus musculus 19-23
29056937-10 2017 CD14+ cells with phenotype of M2 macrophages had high phagocytic activity for monosodium urate crystals. Uric Acid 78-94 CD14 molecule Homo sapiens 0-4
29085633-9 2017 In parallel, urate increased the expression of the transcription factor c-Myc and induced T-cell proliferation. Uric Acid 13-18 MYC proto-oncogene, bHLH transcription factor Homo sapiens 72-77
28808071-8 2017 Insulin resistance partially mediated the effect of uric acid on subsequent hypertension, and the mediation effect of peripheral insulin resistance was significantly greater than that of hepatic insulin resistance (31.3% versus 13.2%; P<0.001, for the difference of mediation effects). Uric Acid 52-61 insulin Homo sapiens 0-7
28928970-9 2017 While UA significantly inhibited NO expression with time course- and dose- dependent manner in the cultured ECs, 10 mg/dl UA also increased expression of inflammation cytokine interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha in vitro. Uric Acid 122-124 C-X-C motif chemokine ligand 8 Homo sapiens 196-232
28928970-10 2017 These abnormalities were associated with UA-induced activation of transcription factor NF-kappaB. Uric Acid 41-43 nuclear factor kappa B subunit 1 Homo sapiens 87-96
28254523-2 2017 Recent studies identified an association between a rare missense single nucleotide variant (SNV) in the ALDH16A1 gene and elevated serum uric acid levels and gout. Uric Acid 137-146 aldehyde dehydrogenase 16 family, member A1 Mus musculus 104-112
28254523-3 2017 The present study explores the mechanisms by which ALDH16A1 influences uric acid homeostasis in the kidney. Uric Acid 71-80 aldehyde dehydrogenase 16 family, member A1 Mus musculus 51-59
28254523-7 2017 Three transporters localized in the apical membrane of the proximal convoluted tubule of the kidney known to influence urate/uric acid homeostasis were found to be up-regulated (Abcc4, Slc16a9) or down-regulated (Slc17a3). Uric Acid 119-124 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 178-183
28254523-7 2017 Three transporters localized in the apical membrane of the proximal convoluted tubule of the kidney known to influence urate/uric acid homeostasis were found to be up-regulated (Abcc4, Slc16a9) or down-regulated (Slc17a3). Uric Acid 119-124 solute carrier family 16 (monocarboxylic acid transporters), member 9 Mus musculus 185-192
28254523-7 2017 Three transporters localized in the apical membrane of the proximal convoluted tubule of the kidney known to influence urate/uric acid homeostasis were found to be up-regulated (Abcc4, Slc16a9) or down-regulated (Slc17a3). Uric Acid 125-134 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 178-183
28808071-2 2017 This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Uric Acid 50-59 insulin Homo sapiens 64-71
28808071-5 2017 Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. Uric Acid 97-106 insulin Homo sapiens 111-118
28808071-6 2017 After adjusting for covariates, the cross-lagged path coefficients (beta1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (beta2 values) from baseline insulin resistance indices to follow-up uric acid (beta1=0.110 versus beta2=0.017; P<0.001, for hepatic insulin resistance; beta1=-0.208 versus beta2=-0.021; P<0.001, for peripheral insulin resistance). Uric Acid 96-105 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 68-73
28808071-6 2017 After adjusting for covariates, the cross-lagged path coefficients (beta1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (beta2 values) from baseline insulin resistance indices to follow-up uric acid (beta1=0.110 versus beta2=0.017; P<0.001, for hepatic insulin resistance; beta1=-0.208 versus beta2=-0.021; P<0.001, for peripheral insulin resistance). Uric Acid 96-105 insulin Homo sapiens 119-126
28928970-11 2017 Furthermore, NF-kappaB inhibitor II prevented UA-induced reduction of NO and increased inflammation cytokines. Uric Acid 46-48 nuclear factor kappa B subunit 1 Homo sapiens 13-22
29035437-9 2017 Cox regression analyses indicated that serum uric acid levels were independently and positively associated with the risk of incident obesity. Uric Acid 45-54 cytochrome c oxidase subunit 8A Homo sapiens 0-3
28987249-3 2017 Thus, this study was conducted to assess the serum UA levels in PIH and to evaluate the diagnostic value of serum UA level in PIH. Uric Acid 51-53 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 64-67
28402018-0 2017 Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. Uric Acid 121-130 solute carrier family 2 member 9 Homo sapiens 106-111
28987249-9 2017 RESULTS: Mean serum UA levels was higher in PIH compared to control group (5.46 +- 1.51 vs 4.03 +- 0.69) respectively. Uric Acid 20-22 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 44-47
28987249-3 2017 Thus, this study was conducted to assess the serum UA levels in PIH and to evaluate the diagnostic value of serum UA level in PIH. Uric Acid 114-116 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 126-129
28987249-10 2017 ROC curve demonstrated that serum UA showed a superior diagnostic efficiency (Sensitivity - 79.07%, Specificity - 71.19%) compared to creatinine (Sensitivity - 62.75%, Specificity - 27.45%) in PIH respectively. Uric Acid 34-36 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 193-196
28770648-0 2017 Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. Uric Acid 10-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-41
28987249-11 2017 CONCLUSION: The present study shows that serum UA is significantly raised in PIH compared to the control group. Uric Acid 47-49 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 77-80
28987249-12 2017 Assessment of uric acid is a convenient and cost-effective method for determination of severity in PIH. Uric Acid 14-23 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 99-102
28987249-13 2017 Thus, serum uric acid can still be used as prevalent marker for risk assessment in PIH. Uric Acid 12-21 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 83-86
28770648-7 2017 Uric acid elevated COX-2 levels in a time-dependent manner. Uric Acid 0-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-24
28770648-8 2017 Angiotensin-II receptor blocker, losartan, diminished uric-acid-induced COX-2 elevation. Uric Acid 54-63 prostaglandin-endoperoxide synthase 2 Homo sapiens 72-77
28988709-1 2017 BACKGROUND: Selective inhibitors of human urate transporter 1 (hURAT1) are considered to be effective treatment for hyperuricemia and gout, which can reduce the reabsorption of more than 90% of uric acid in the proximal tubule of the kidney. Uric Acid 194-203 solute carrier family 22 member 12 Homo sapiens 42-61
28770648-10 2017 Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways. Uric Acid 0-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-84
28770648-11 2017 This is the first study demonstrating losartan"s ability to reduce uric-acid-induced COX-2 elevation. Uric Acid 67-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 85-90
28988709-1 2017 BACKGROUND: Selective inhibitors of human urate transporter 1 (hURAT1) are considered to be effective treatment for hyperuricemia and gout, which can reduce the reabsorption of more than 90% of uric acid in the proximal tubule of the kidney. Uric Acid 194-203 solute carrier family 22 member 12 Homo sapiens 63-69
28988709-2 2017 We aimed to design and synthesize a more potent hURAT1 based on the structure of Lesinurad (LU), which was reported to lower uric acid levels with IC50 value of hURAT1 (about 60muM). Uric Acid 125-134 solute carrier family 22 member 12 Homo sapiens 48-54
28988709-7 2017 RESULTS: The [14C] Urate uptake assay using hURAT1 stably transfected MDCK cells indicated that LUM was more potent than LU against hURAT1, with IC50 values of 3.22muM and 65.47muM, respectively. Uric Acid 19-24 lumican Canis lupus familiaris 96-99
28988709-9 2017 In vivo, LUM-Na (40mg/kg) showed more potent activity in reducing serum uric acid levels in potassium oxonate-induced hyperuricemic rats, compared to similar doses of LU-Na. Uric Acid 72-81 lumican Homo sapiens 9-12
28679589-0 2017 Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. Uric Acid 19-28 ATP binding cassette subfamily G member 2 Rattus norvegicus 81-122
28894234-7 2017 UMOD methylation level was shown to be significantly correlated with the serum level of uric acid (UA) (r = -0.208, P = 0.035). Uric Acid 88-97 uromodulin Homo sapiens 0-4
28894234-7 2017 UMOD methylation level was shown to be significantly correlated with the serum level of uric acid (UA) (r = -0.208, P = 0.035). Uric Acid 99-101 uromodulin Homo sapiens 0-4
28705588-9 2017 Moreover, IL-33 was increased in EP patients and IL-33 concentrations correlated with UA and ATP concentrations. Uric Acid 86-88 interleukin 33 Homo sapiens 10-15
28705588-9 2017 Moreover, IL-33 was increased in EP patients and IL-33 concentrations correlated with UA and ATP concentrations. Uric Acid 86-88 interleukin 33 Homo sapiens 49-54
28705588-11 2017 UA concentrations correlated with eosinophil numbers, and with ATP and IL-33 concentrations. Uric Acid 0-2 interleukin 33 Homo sapiens 71-76
28749169-6 2017 Additional beneficial effect of SGLT2 inhibitors on serum uric acid level reduction is investigated. Uric Acid 58-67 solute carrier family 5 member 2 Homo sapiens 32-37
29066486-8 2017 Cox regression analyses indicated that serum uric acid levels were independently and positively associated with the risk of incident hypertriglyceridemia. Uric Acid 45-54 cytochrome c oxidase subunit 8A Homo sapiens 0-3
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 39-48 solute carrier family 5 member 2 Homo sapiens 62-67
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 39-48 solute carrier family 2 member 9 Homo sapiens 246-251
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 145-154 solute carrier family 5 member 2 Homo sapiens 62-67
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 145-154 solute carrier family 2 member 9 Homo sapiens 246-251
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 145-154 solute carrier family 5 member 2 Homo sapiens 62-67
28749169-8 2017 As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Uric Acid 145-154 solute carrier family 2 member 9 Homo sapiens 246-251
28748114-6 2017 However, microorganisms produce group of degrading enzymes uricase, allantoinase, allantoicase and urease, which catalyze the degradation of uric acid to the ammonia. Uric Acid 141-150 urate oxidase (pseudogene) Homo sapiens 59-66
29187338-1 2017 Mice infected with mouse hepatitis virus A59 (MHV-A59) develop hepatitis and autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH), a fact closely related to the release of alarmins such as uric acid and/or high-mobility group box protein 1 (HMGB1). Uric Acid 216-225 fumarylacetoacetate hydrolase Mus musculus 152-155
28605936-11 2017 The receiver operating characteristic curve showed that increasing AAC was associated with low urine pH (area under the curve [AUC] 0.683, p = 0.002) and uric acid stone formation (AUC 0.698, p = 0.045). Uric Acid 154-163 glycine-N-acyltransferase Homo sapiens 67-70
29207693-2 2017 Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive. Uric Acid 38-47 COPD Homo sapiens 56-60
29207693-2 2017 Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive. Uric Acid 49-51 COPD Homo sapiens 56-60
29207693-3 2017 Aim: To measure the serum UA levels among COPD subjects and to correlate with different stages of the disease. Uric Acid 26-28 COPD Homo sapiens 42-46
29207693-8 2017 COPD cases had significantly higher level of UA compared to control subjects (4.85+-1.67 vs. 2.32+-0.93 mg/dl, respectively, p<0.001). Uric Acid 45-47 COPD Homo sapiens 0-4
29207693-9 2017 Female subjects with COPD had higher levels of UA compared to their male counterparts (5.15+-1.89 vs. 4.59+-1.45 mg/dl, respectively, p=0.3). Uric Acid 47-49 COPD Homo sapiens 21-25
28605936-12 2017 CONCLUSIONS: NCCT-based diagnosis of AAC is associated with low urine pH, hypocitraturia, and uric acid stone formation. Uric Acid 94-103 glycine-N-acyltransferase Homo sapiens 37-40
28372155-3 2017 The PPy-GOx/PPy-Cl bilayer biosensor was effective in rejecting 98% of ascorbic acid and 100% of glycine, glutamic acid and uric acid. Uric Acid 124-133 hydroxyacid oxidase 1 Homo sapiens 8-11
28397058-5 2017 RESULTS: Patients with different homozygous G6PC mutations showed important differences in height, BMI, and biochemical parameters (i.e., lactate, uric acid, triglyceride, and cholesterol concentrations). Uric Acid 147-156 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 44-48
28700826-5 2017 Moreover, when the annealed coal/GCE sensor was applied for the determination of ascorbic acid, dopamine, uric acid, guanine, and adenine commonly contained in blood samples and urine samples, it also exhibited excellent detection performance with strong electrocatalytic activity. Uric Acid 106-115 aminomethyltransferase Homo sapiens 33-36
28550118-0 2017 S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals. Uric Acid 83-99 S100 calcium binding protein A9 Homo sapiens 0-6
28456721-2 2017 Significant adenosine triphosphate-dependent uptake by MRP4 was observed for ochratoxin A, pitavastatin, raltitrexed (Km = 43.7 muM), pravastatin, cyclic guanosine monophosphate, 2,4-dichlorophenoxyacetate, and urate. Uric Acid 211-216 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 55-59
28885369-7 2017 Otherwise, serum levels of C-peptide, premixed insulin injection, history of cardiovascular disease, and serum concentration of uric acid were inversely associated with GV parameters.Dysfunction of pancreatic beta-cell and better insulin sensitivity were independent contributors to the fluctuation of blood glucose. Uric Acid 128-137 insulin Homo sapiens 230-237
28863172-11 2017 In HBEC-6KT, production of uric acid was sensitive to the xanthine dehydrogenase (XDH) inhibitor, allopurinol, and the ATP Binding Cassette C4 (ABCC4) inhibitor, MK-571. Uric Acid 27-36 xanthine dehydrogenase Homo sapiens 58-80
28863172-11 2017 In HBEC-6KT, production of uric acid was sensitive to the xanthine dehydrogenase (XDH) inhibitor, allopurinol, and the ATP Binding Cassette C4 (ABCC4) inhibitor, MK-571. Uric Acid 27-36 xanthine dehydrogenase Homo sapiens 82-85
28863172-11 2017 In HBEC-6KT, production of uric acid was sensitive to the xanthine dehydrogenase (XDH) inhibitor, allopurinol, and the ATP Binding Cassette C4 (ABCC4) inhibitor, MK-571. Uric Acid 27-36 ATP binding cassette subfamily C member 4 Homo sapiens 119-142
28863172-11 2017 In HBEC-6KT, production of uric acid was sensitive to the xanthine dehydrogenase (XDH) inhibitor, allopurinol, and the ATP Binding Cassette C4 (ABCC4) inhibitor, MK-571. Uric Acid 27-36 ATP binding cassette subfamily C member 4 Homo sapiens 144-149
28863172-12 2017 Lastly, the pro-inflammatory cytokine combination of TNF-alpha and IFN-gamma elevated extracellular uric acid levels and XDH gene expression in HBEC-6KT cells. Uric Acid 100-109 tumor necrosis factor Homo sapiens 53-62
28863172-12 2017 Lastly, the pro-inflammatory cytokine combination of TNF-alpha and IFN-gamma elevated extracellular uric acid levels and XDH gene expression in HBEC-6KT cells. Uric Acid 100-109 interferon gamma Homo sapiens 67-76
29225919-8 2017 SIFT scores were significantly correlated with the urate transport function, although some ABCG2 variants showed inconsistent scores. Uric Acid 51-56 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 91-96
29056013-6 2017 Baseline level comparison: ALT (t = -4.379, P < 0.01) AST (t = -3.847, P < 0.01) GGT (t = -2.763, P < 0.01) and F (chi(2) = 20.341, P < 0.01), There were significant difference (P < 0.05); There were no significant differences in the levels of blood lipids, blood glucose, uric acid, inflammation and fibrosis. Uric Acid 289-298 solute carrier family 17 member 5 Homo sapiens 57-60
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 214-223 xanthine dehydrogenase Homo sapiens 24-47
28797095-1 2017 BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals. Uric Acid 133-149 interleukin 1 beta Homo sapiens 90-107
28797095-1 2017 BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals. Uric Acid 133-149 interleukin 1 beta Homo sapiens 109-117
28797095-1 2017 BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals. Uric Acid 151-154 interleukin 1 beta Homo sapiens 90-107
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 214-223 xanthine dehydrogenase Homo sapiens 49-52
28797095-1 2017 BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals. Uric Acid 151-154 interleukin 1 beta Homo sapiens 109-117
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 214-223 xanthine dehydrogenase Homo sapiens 122-144
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 225-227 xanthine dehydrogenase Homo sapiens 24-47
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 225-227 xanthine dehydrogenase Homo sapiens 49-52
28797123-1 2017 BACKGROUND AND PURPOSE: Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase, the latter of which produces superoxide during uric acid (UA) synthesis. Uric Acid 225-227 xanthine dehydrogenase Homo sapiens 122-144
28797123-5 2017 Among 270 patients who were not taking UA-lowering drugs, XOR activity was associated with body mass index (BMI), alanine aminotransferase (ALT), HbA1c and renal function. Uric Acid 39-41 xanthine dehydrogenase Homo sapiens 58-61
28797123-6 2017 Although XOR activity was not associated with serum UA overall, patients with chronic kidney disease (CKD), those with higher XOR activity had higher serum UA among patients without CKD. Uric Acid 156-158 xanthine dehydrogenase Homo sapiens 126-129
28789618-11 2017 CONCLUSIONS: Previous studies have found that SNPs in SFMBT1 are associated with blood pressure and serum urate concentration, suggesting that SFMBT1 may have functional implications in some metabolic-related traits. Uric Acid 106-111 Scm like with four mbt domains 1 Homo sapiens 54-60
28789618-11 2017 CONCLUSIONS: Previous studies have found that SNPs in SFMBT1 are associated with blood pressure and serum urate concentration, suggesting that SFMBT1 may have functional implications in some metabolic-related traits. Uric Acid 106-111 Scm like with four mbt domains 1 Homo sapiens 143-149
28701671-0 2017 Is Serum Uric Acid Independently Associated With Left Ventricular Mass Index, Ejection Fraction, and B-Type Natriuretic Peptide Among Female and Male Cardiac Patients? Uric Acid 9-18 natriuretic peptide B Homo sapiens 101-127
28786993-6 2017 Following uric acid administration, there was an accentuated increase in IL-6 during the oral lipid tolerance test (P<0.001). Uric Acid 10-19 interleukin 6 Homo sapiens 73-77
28786993-9 2017 In health individuals, acute increase in uric acid results in an increased IL-6 response when challenged with lipid load. Uric Acid 41-50 interleukin 6 Homo sapiens 75-79
28539355-3 2017 Furthermore, high-fructose diets result in elevated plasma concentrations of uric acid via xanthine oxidase (XO) activation, and uric acid elevation is also associated with increased vascular stiffness. Uric Acid 77-86 xanthine dehydrogenase Mus musculus 91-107
28527616-8 2017 It is concluded that the H2O2 needed for catalase activity is derived from the oxidation of (hypo)xanthine by xanthine oxidase and the oxidation of urate by uricase. Uric Acid 148-153 catalase Rattus norvegicus 41-49
27862937-4 2017 The CL probe was designed for SUA The linear range of the uric acid concentration was 0.6-9 muM and the detection limit was 0.1 muM. Uric Acid 58-67 latexin Homo sapiens 92-95
27688246-6 2017 Conversely, adiponectin levels were significantly negatively (r = -0.310; p < 0.05) associated with serum uric acid concentration. Uric Acid 109-118 adiponectin, C1Q and collagen domain containing Homo sapiens 12-23
28725568-2 2017 He"s a compound heterozygote for the sulfite oxidase gene, presenting low cystine, undetectable homocysteine and normal uric acid blood concentrations and undetectable sulfite oxidase activity in his cultured fibroblasts. Uric Acid 120-129 sulfite oxidase Homo sapiens 37-52
28248530-2 2017 We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. Uric Acid 109-118 insulin Homo sapiens 138-145
28248530-8 2017 Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk. Uric Acid 6-15 insulin Homo sapiens 171-178
28890842-0 2017 Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid. Uric Acid 134-143 urate oxidase (pseudogene) Homo sapiens 89-96
28890842-1 2017 First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages-oxidation followed by hydration. Uric Acid 166-175 urate oxidase (pseudogene) Homo sapiens 125-132
28890842-1 2017 First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages-oxidation followed by hydration. Uric Acid 166-175 urate oxidase (pseudogene) Homo sapiens 238-245
28890842-1 2017 First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages-oxidation followed by hydration. Uric Acid 177-179 urate oxidase (pseudogene) Homo sapiens 125-132
28890842-1 2017 First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages-oxidation followed by hydration. Uric Acid 177-179 urate oxidase (pseudogene) Homo sapiens 238-245
28890842-5 2017 The mechanistic insights not only provide a mechanistic base for future rational design of uricase mutants with improved catalytic activity against uric acid as an improved enzyme therapy, but also are valuable for understanding a variety of other cofactor-free oxidase-catalyzed reactions involving an oxygen molecule. Uric Acid 148-157 urate oxidase (pseudogene) Homo sapiens 91-98
28763896-0 2017 [Association between serum uric acid levels and high sensitive C-reactive protein in patients with type 2 diabetes]. Uric Acid 27-36 C-reactive protein Homo sapiens 63-81
28763896-1 2017 Objective: To investigate the relationship between serum uric acid (SUA) levels and high sensitive C-reactive protein (hs-CRP) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 57-66 C-reactive protein Homo sapiens 99-117
28736373-6 2017 Serum uric acid levels were negatively correlated with eGFR (r=-0.421, P<0.001) and positively correlated with C-reactive protein level (r=0.093, P=0.025). Uric Acid 6-15 epidermal growth factor receptor Homo sapiens 55-59
28410202-6 2017 Among polymorphisms identified in the present study, rs76974938 [C/T (D67N)] of C21orf59 and rs188780113 [G/A (R478C)] of ATG2A may be novel determinants of estimated glomerular filtration rate and chronic kidney disease or of the serum concentration of uric acid, respectively. Uric Acid 254-263 autophagy related 2A Homo sapiens 122-127
28371506-12 2017 A rare population-specific allele (P1036L) with predicted strong functional consequence reduced the uric acid transport activity of ABCC4 by 30%. Uric Acid 100-109 ATP binding cassette subfamily C member 4 Homo sapiens 132-137
28371506-13 2017 CONCLUSION: An association between ABCC4 and gout and fractional excretion of uric acid is consistent with the established role of MRP4 as a unidirectional renal uric acid efflux pump. Uric Acid 78-87 ATP binding cassette subfamily C member 4 Homo sapiens 35-40
28371506-13 2017 CONCLUSION: An association between ABCC4 and gout and fractional excretion of uric acid is consistent with the established role of MRP4 as a unidirectional renal uric acid efflux pump. Uric Acid 78-87 ATP binding cassette subfamily C member 4 Homo sapiens 131-135
28371506-13 2017 CONCLUSION: An association between ABCC4 and gout and fractional excretion of uric acid is consistent with the established role of MRP4 as a unidirectional renal uric acid efflux pump. Uric Acid 162-171 ATP binding cassette subfamily C member 4 Homo sapiens 35-40
28371506-13 2017 CONCLUSION: An association between ABCC4 and gout and fractional excretion of uric acid is consistent with the established role of MRP4 as a unidirectional renal uric acid efflux pump. Uric Acid 162-171 ATP binding cassette subfamily C member 4 Homo sapiens 131-135
28758502-4 2017 UA concentrations within the normal physiological range had no effect, while treatment with a high level of UA, i.e. 1200 muM, increased the malondialdehyde (MDA) and protein carbonyl contents, decreased the superoxide dismutase (SOD) and catalase (CAT) activities, and had no effect on glutathione (GSH) in cardiac muscle cells. Uric Acid 108-110 catalase Gallus gallus 239-247
28758502-5 2017 In addition, the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was stimulated in cells treated with 1200 muM UA. Uric Acid 122-124 nuclear factor, erythroid 2 like 2 Gallus gallus 17-60
28758502-4 2017 UA concentrations within the normal physiological range had no effect, while treatment with a high level of UA, i.e. 1200 muM, increased the malondialdehyde (MDA) and protein carbonyl contents, decreased the superoxide dismutase (SOD) and catalase (CAT) activities, and had no effect on glutathione (GSH) in cardiac muscle cells. Uric Acid 108-110 catalase Gallus gallus 249-252
28758502-5 2017 In addition, the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was stimulated in cells treated with 1200 muM UA. Uric Acid 122-124 nuclear factor, erythroid 2 like 2 Gallus gallus 62-66
28758502-7 2017 Treatment with UA within the normal physiological range reduced the increased MDA and protein carbonyl contents and SOD enzymatic activity induced by H2O2 exposure to some extent and inhibited reactive oxygen species (ROS) formation, presumably as a result of the Nrf2 pathway activation in H2O2-damaged cells. Uric Acid 15-17 nuclear factor, erythroid 2 like 2 Gallus gallus 264-268
28508122-3 2017 To this end, we studied the effect of PEG conjugation on the activity and stability of the enzymatic complement required for conversion of urate into the more soluble (S)-allantoin. Uric Acid 139-144 progestagen associated endometrial protein Homo sapiens 38-41
28758502-8 2017 By contrast, the MDA and protein carbonyl contents were increased, SOD enzymatic activity was depressed, and the Nrf2 pathway was further down-regulated in H2O2-damaged cells treated with 1200 muM UA. Uric Acid 197-199 nuclear factor, erythroid 2 like 2 Gallus gallus 113-117
28911646-1 2017 Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Uric Acid 0-9 xanthine dehydrogenase Mus musculus 68-84
28911646-1 2017 Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Uric Acid 11-13 xanthine dehydrogenase Mus musculus 68-84
27659403-2 2017 From HMGB1, S100A8/A9 and S100A12 proteins, over heat-shock proteins (HSPs) and purine metabolites (e.g. uric acid, ATP) to altered matrix proteins and interleukin-33 (IL-33), a number of alarmins have been determined until now as having a role in rheumatoid arthritis, psoriatic and juvenile idiopathic arthritis, as well as spondyloarthritis and gout. Uric Acid 105-114 interleukin 33 Homo sapiens 152-166
27659403-2 2017 From HMGB1, S100A8/A9 and S100A12 proteins, over heat-shock proteins (HSPs) and purine metabolites (e.g. uric acid, ATP) to altered matrix proteins and interleukin-33 (IL-33), a number of alarmins have been determined until now as having a role in rheumatoid arthritis, psoriatic and juvenile idiopathic arthritis, as well as spondyloarthritis and gout. Uric Acid 105-114 interleukin 33 Homo sapiens 168-173
28611861-6 2017 SGLT2is reduced body weight, systolic and diastolic blood pressures, plasma glucose, hemoglobin A1c, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, uric acid, triglyceride and non-high-density lipoprotein-cholesterol (HDL-C), and elevated HDL-C; however, they did not affect LDL-cholesterol levels. Uric Acid 182-191 solute carrier family 5 member 2 Homo sapiens 0-5
28611861-8 2017 CONCLUSION: The present study demonstrated that SGLT2i ameliorated body weight, blood pressure, liver function, serum lipids and uric acid, in addition to improvement of glucose metabolism in patients with type 2 diabetes. Uric Acid 129-138 solute carrier family 5 member 2 Homo sapiens 48-53
28671562-4 2017 The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 muM (S/N = 3) and 0.01 muA/muM, respectively, in the range of 1-300 muM of UA. Uric Acid 68-70 latexin Homo sapiens 80-83
28671562-4 2017 The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 muM (S/N = 3) and 0.01 muA/muM, respectively, in the range of 1-300 muM of UA. Uric Acid 68-70 latexin Homo sapiens 107-110
28671562-4 2017 The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 muM (S/N = 3) and 0.01 muA/muM, respectively, in the range of 1-300 muM of UA. Uric Acid 68-70 latexin Homo sapiens 107-110
28381705-6 2017 Multiple regression analysis revealed that LVMI, EF, plasma levels of albumin, C-reactive protein, and uric acid were the predictors of BNP levels (P<0.001, P<0.001, P=0.009, P=0.012, and P=0.018, respectively). Uric Acid 103-112 natriuretic peptide B Homo sapiens 136-139
28630638-12 2017 CONCLUSION: These findings indicate that chicory increases uric acid excretion by intestines, which may be related to the stimulation of intestinal uric acid excretion via down-regulating the mRNA and protein expressions of ABCG2. Uric Acid 59-68 ATP binding cassette subfamily G member 2 Rattus norvegicus 224-229
27635596-9 2017 CONCLUSION: Urate deposition, synovitis, and bone erosion are common at the MTP1 joint in people with gout, even in the absence of flare. Uric Acid 12-17 solute carrier family 40 member 1 Homo sapiens 76-80
28428355-8 2017 Each A-allele of the SLC2A9 rs7442295 was associated with 9% higher plasma urate and hazard ratios of 1.07 (1.01-1.14) for cancer incidence and 1.07 (1.02-1.13) for all-cause mortality. Uric Acid 75-80 solute carrier family 2 member 9 Homo sapiens 21-27
28408375-0 2017 Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-kappaB Signaling Pathway in HepG2 Cells. Uric Acid 0-9 nuclear factor kappa B subunit 1 Homo sapiens 97-106
28408375-4 2017 APPROACH AND RESULTS: Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. Uric Acid 78-80 C-reactive protein Homo sapiens 133-151
28408375-4 2017 APPROACH AND RESULTS: Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. Uric Acid 78-80 fibrinogen beta chain Homo sapiens 153-163
28408375-7 2017 We show that UA stimulates the expression of C-reactive protein, fibrinogen, ferritin, and complement C3 in a dose-dependent fashion. Uric Acid 13-15 C-reactive protein Homo sapiens 45-63
28408375-7 2017 We show that UA stimulates the expression of C-reactive protein, fibrinogen, ferritin, and complement C3 in a dose-dependent fashion. Uric Acid 13-15 fibrinogen beta chain Homo sapiens 65-75
28408375-7 2017 We show that UA stimulates the expression of C-reactive protein, fibrinogen, ferritin, and complement C3 in a dose-dependent fashion. Uric Acid 13-15 complement C3 Homo sapiens 91-104
28408375-9 2017 Exposure of cells to UA resulted in activation of the IkappaB kinase/IkappaBalpha/NF-kappaB signaling pathway that was attenuated by benzbromarone. Uric Acid 21-23 NFKB inhibitor alpha Homo sapiens 69-81
28408375-9 2017 Exposure of cells to UA resulted in activation of the IkappaB kinase/IkappaBalpha/NF-kappaB signaling pathway that was attenuated by benzbromarone. Uric Acid 21-23 nuclear factor kappa B subunit 1 Homo sapiens 82-91
28374152-3 2017 Here, we studied the role of the innate imunity receptor NLRP3/ASC in UA induced epithelial-mesenchymal transition (EMT) in kidney. Uric Acid 70-72 NLR family, pyrin domain containing 3 Rattus norvegicus 57-62
28569730-5 2017 This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis. Uric Acid 125-134 NLR family pyrin domain containing 3 Homo sapiens 147-152
28569730-5 2017 This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis. Uric Acid 125-134 caspase 1 Homo sapiens 169-178
28569730-5 2017 This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis. Uric Acid 125-134 interleukin 1 beta Homo sapiens 201-213
28569730-5 2017 This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis. Uric Acid 125-134 interleukin 1 beta Homo sapiens 205-213
29622969-9 2017 Serum osteoprotegerin correlated positively with serum phosphorus, calcium phosphorus product, alkaline phosphatase, iPTH, C-reactive protein, serum uric acid, low-density lipoprotein (LDL) and left ventricular mass index (LVMI) (p < 0.005), and negatively with hemoglobin, ejection fraction (p < 0.005) and HDL (p < 0.05). Uric Acid 149-158 TNF receptor superfamily member 11b Homo sapiens 6-21
28587378-6 2017 LA activated Akt signaling and inhibition of Akt signaling abolished the effects of LA on cell viability, NO production, ROS production and ATP levels in UA-treated endothelial cells. Uric Acid 154-156 AKT serine/threonine kinase 1 Rattus norvegicus 13-16
28587378-6 2017 LA activated Akt signaling and inhibition of Akt signaling abolished the effects of LA on cell viability, NO production, ROS production and ATP levels in UA-treated endothelial cells. Uric Acid 154-156 AKT serine/threonine kinase 1 Rattus norvegicus 45-48
28587378-7 2017 Therefore, the current study demonstrated that LA attenuated oxidant stress and inhibited apoptosis in UA-treated endothelial cells by activating Akt signaling. Uric Acid 103-105 AKT serine/threonine kinase 1 Rattus norvegicus 146-149
28374152-3 2017 Here, we studied the role of the innate imunity receptor NLRP3/ASC in UA induced epithelial-mesenchymal transition (EMT) in kidney. Uric Acid 70-72 PYD and CARD domain containing Rattus norvegicus 63-66
28374152-7 2017 High UA also increased the expression of NLRP3/ASC with activation of both inflammasome related caspase-1 and inflammasome unrelated Smad 2/3 pathways. Uric Acid 5-7 NLR family, pyrin domain containing 3 Rattus norvegicus 41-46
28374152-7 2017 High UA also increased the expression of NLRP3/ASC with activation of both inflammasome related caspase-1 and inflammasome unrelated Smad 2/3 pathways. Uric Acid 5-7 PYD and CARD domain containing Rattus norvegicus 47-50
28374152-7 2017 High UA also increased the expression of NLRP3/ASC with activation of both inflammasome related caspase-1 and inflammasome unrelated Smad 2/3 pathways. Uric Acid 5-7 caspase 1 Rattus norvegicus 96-105
28374152-7 2017 High UA also increased the expression of NLRP3/ASC with activation of both inflammasome related caspase-1 and inflammasome unrelated Smad 2/3 pathways. Uric Acid 5-7 SMAD family member 2 Rattus norvegicus 133-141
28374152-10 2017 In conclusion, kidney epithelial NLRP3/ASC expression was increased in high UA state in rats and both inflammasome related caspase-1 and non-inflammasome related P-Smad 2/3 pathways were associated with the observed EMT, inflammation and fibrosis induced by UA in the kidney. Uric Acid 76-78 NLR family, pyrin domain containing 3 Rattus norvegicus 33-38
28374152-10 2017 In conclusion, kidney epithelial NLRP3/ASC expression was increased in high UA state in rats and both inflammasome related caspase-1 and non-inflammasome related P-Smad 2/3 pathways were associated with the observed EMT, inflammation and fibrosis induced by UA in the kidney. Uric Acid 76-78 PYD and CARD domain containing Rattus norvegicus 39-42
28374152-10 2017 In conclusion, kidney epithelial NLRP3/ASC expression was increased in high UA state in rats and both inflammasome related caspase-1 and non-inflammasome related P-Smad 2/3 pathways were associated with the observed EMT, inflammation and fibrosis induced by UA in the kidney. Uric Acid 258-260 NLR family, pyrin domain containing 3 Rattus norvegicus 33-38
28374152-10 2017 In conclusion, kidney epithelial NLRP3/ASC expression was increased in high UA state in rats and both inflammasome related caspase-1 and non-inflammasome related P-Smad 2/3 pathways were associated with the observed EMT, inflammation and fibrosis induced by UA in the kidney. Uric Acid 258-260 PYD and CARD domain containing Rattus norvegicus 39-42
28566086-2 2017 Key findings include the reporting of 28 urate-associated loci, the discovery that ABCG2 plays a central role on extra-renal uric acid excretion, the identification of genes associated with development of gout in the context of hyperuricaemia, recognition that ABCG2 variants influence allopurinol response, and the impact of HLA-B*5801 testing in reducing the prevalence of allopurinol hypersensitivity in high-risk populations. Uric Acid 125-134 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 83-88
28251464-8 2017 Our study suggests that low serum UA concentration is associated with the occurrence of FOG in PD. Uric Acid 34-36 zinc finger protein, FOG family member 1 Homo sapiens 88-91
28557965-4 2017 Moreover, abnormally elevated levels of uric acid results in the activation of renin-angiotensinaldosterone system and thus it may be associated with disturbances of water and electrolyte balance and the appearance of hypertension. Uric Acid 40-49 renin Homo sapiens 79-84
28484006-0 2017 Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Uric Acid 0-9 AKT serine/threonine kinase 1 Homo sapiens 54-57
28484006-0 2017 Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Uric Acid 0-9 AKT1 substrate 1 Homo sapiens 58-64
28484006-3 2017 In this study, we investigated the mechanisms through which uric acid selectively lowers human blood monocyte production of the natural inhibitor IL-1 receptor antagonist (IL-1Ra) and shifts production toward the highly inflammatory IL-1beta. Uric Acid 60-69 interleukin 1 receptor antagonist Homo sapiens 146-170
28557965-8 2017 A positive correlation between serum creatinine and uric acid (Spearman coefficient 0.426, p<0.0001) and negative correlation between uric acid and eGFR (Spearman coefficient -0.116, p =0.068) were demonstrated in this study. Uric Acid 137-146 epidermal growth factor receptor Homo sapiens 151-155
28484006-3 2017 In this study, we investigated the mechanisms through which uric acid selectively lowers human blood monocyte production of the natural inhibitor IL-1 receptor antagonist (IL-1Ra) and shifts production toward the highly inflammatory IL-1beta. Uric Acid 60-69 interleukin 1 receptor antagonist Homo sapiens 172-178
28539973-2 2017 BACKGROUND: The first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. Uric Acid 115-120 metallothionein 1B Homo sapiens 55-58
28484006-3 2017 In this study, we investigated the mechanisms through which uric acid selectively lowers human blood monocyte production of the natural inhibitor IL-1 receptor antagonist (IL-1Ra) and shifts production toward the highly inflammatory IL-1beta. Uric Acid 60-69 interleukin 1 beta Homo sapiens 233-241
28484006-6 2017 Functional validation did not identify NF-kappaB or AMP-activated protein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in turn activated mTOR. Uric Acid 102-111 AKT serine/threonine kinase 1 Homo sapiens 147-150
28484006-6 2017 Functional validation did not identify NF-kappaB or AMP-activated protein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in turn activated mTOR. Uric Acid 102-111 AKT1 substrate 1 Homo sapiens 155-188
28484006-6 2017 Functional validation did not identify NF-kappaB or AMP-activated protein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in turn activated mTOR. Uric Acid 102-111 AKT1 substrate 1 Homo sapiens 190-197
28484006-6 2017 Functional validation did not identify NF-kappaB or AMP-activated protein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in turn activated mTOR. Uric Acid 102-111 mechanistic target of rapamycin kinase Homo sapiens 224-228
28484006-9 2017 Thus, the Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype. Uric Acid 45-54 AKT serine/threonine kinase 1 Homo sapiens 10-13
28484006-9 2017 Thus, the Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype. Uric Acid 45-54 AKT1 substrate 1 Homo sapiens 14-20
28484006-9 2017 Thus, the Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype. Uric Acid 103-112 AKT serine/threonine kinase 1 Homo sapiens 10-13
28484006-9 2017 Thus, the Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype. Uric Acid 103-112 AKT1 substrate 1 Homo sapiens 14-20
28539294-6 2017 In rats with hyperuricemia, serum uric acid level was positively correlated with the levels of LPS, IL-6 and TNF-alpha, and their serum levels decreased significantly and progressively with time in Benzbromarone group and Clostridium butyricum group. Uric Acid 34-43 interleukin 6 Rattus norvegicus 100-104
28539294-6 2017 In rats with hyperuricemia, serum uric acid level was positively correlated with the levels of LPS, IL-6 and TNF-alpha, and their serum levels decreased significantly and progressively with time in Benzbromarone group and Clostridium butyricum group. Uric Acid 34-43 tumor necrosis factor Rattus norvegicus 109-118
28390941-5 2017 RESULTS: G. affine extract showed expressive results on active in reducing serum uric acid (Sur) through effect renal mGLUT9 and mURAT1 mainly and inhibit XO activity in vivo. Uric Acid 81-90 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 118-124
28442634-7 2017 It also reduced expression of the urate anion exchanger 1, which promotes reabsorption of uric acid, and preserved expression of organic anion transporters 1 and 3, which accelerate uric acid excretion in the kidney of hyperuricemic rats. Uric Acid 182-191 solute carrier family 22 member 6 Rattus norvegicus 129-163
28442634-9 2017 In cultured renal interstitial fibroblasts, inhibition of ERK1/2 activation by siRNA suppressed uric acid-induced activation of renal interstitial fibroblasts. Uric Acid 96-105 mitogen activated protein kinase 3 Rattus norvegicus 58-64
28442634-10 2017 Collectively, pharmacologic targeting of ERK1/2 can alleviate HN by suppressing TGF-beta signaling, reducing inflammation responses, and inhibiting the molecular processes associated with elevation of blood uric acid levels in the body. Uric Acid 207-216 mitogen activated protein kinase 3 Rattus norvegicus 41-47
28539925-4 2017 It was demonstrated that CXCL9(74-103) binds with high affinity to GAGs, competed with active chemokines for GAG binding and thereby inhibited CXCL8- and monosodium urate (MSU) crystal-induced neutrophil migration to joints. Uric Acid 154-170 chemokine (C-X-C motif) ligand 9 Mus musculus 25-30
28539925-4 2017 It was demonstrated that CXCL9(74-103) binds with high affinity to GAGs, competed with active chemokines for GAG binding and thereby inhibited CXCL8- and monosodium urate (MSU) crystal-induced neutrophil migration to joints. Uric Acid 172-175 chemokine (C-X-C motif) ligand 9 Mus musculus 25-30
28390941-5 2017 RESULTS: G. affine extract showed expressive results on active in reducing serum uric acid (Sur) through effect renal mGLUT9 and mURAT1 mainly and inhibit XO activity in vivo. Uric Acid 81-90 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 129-135
27899376-7 2017 Localisation analysis in the human kidney revealed expression of NIPAL1 and FAM35A mainly in the distal tubules, which suggests the involvement of the distal nephron in urate handling in humans. Uric Acid 169-174 NIPA like domain containing 1 Homo sapiens 65-71
27899376-7 2017 Localisation analysis in the human kidney revealed expression of NIPAL1 and FAM35A mainly in the distal tubules, which suggests the involvement of the distal nephron in urate handling in humans. Uric Acid 169-174 shieldin complex subunit 2 Homo sapiens 76-82
28183204-5 2017 Cox regression analysis was used to estimate the association between serum uric acid, renal function-normalized serum uric acid and incident chronic kidney disease. Uric Acid 75-84 cytochrome c oxidase subunit 8A Homo sapiens 0-3
28183204-5 2017 Cox regression analysis was used to estimate the association between serum uric acid, renal function-normalized serum uric acid and incident chronic kidney disease. Uric Acid 118-127 cytochrome c oxidase subunit 8A Homo sapiens 0-3
27677364-10 2017 Plasma aspartate concentration was increased (P<0.05), whereas plasma glutamine, hypoxanthine and uric acid concentrations were decreased (P<0.05) by BCAA supplementation. Uric Acid 101-110 AT-rich interaction domain 4B Homo sapiens 156-160
28425024-1 2017 Lesinurad (Zurampic ) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Uric Acid 75-84 solute carrier family 22 member 11 Homo sapiens 70-74
28425024-1 2017 Lesinurad (Zurampic ) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Uric Acid 86-88 solute carrier family 22 member 11 Homo sapiens 70-74
28425024-1 2017 Lesinurad (Zurampic ) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Uric Acid 140-142 solute carrier family 22 member 12 Homo sapiens 60-65
28425024-1 2017 Lesinurad (Zurampic ) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Uric Acid 140-142 solute carrier family 22 member 11 Homo sapiens 70-74
27356124-7 2017 Myostatin was shown to be positively associated with fasting plasma glucose, HOMA-IR, hepatic enzymes, uric acid, and FINDRISC questionnaire scores in both sexes. Uric Acid 103-112 myostatin Homo sapiens 0-9
27677364-11 2017 CONCLUSIONS: The findings suggest that BCAA supplements not only provided additional substrate to meet the energy demands of the athletes during endurance exercise but also reduced their PNC activity, and subsequently decreased uric acid production and reduced the incidence of gout in a person engaging in endurance exercise. Uric Acid 228-237 AT-rich interaction domain 4B Homo sapiens 39-43
28355168-8 2017 RESULTS: In multivariable analysis, uric acid (per SD of 38 mumol/l) was associated with DBP z-scores [sbeta 0.07; confidence interval (CI), 0.01-1.14], but not with SBP z-scores. Uric Acid 36-45 D-box binding PAR bZIP transcription factor Homo sapiens 89-92
27623174-7 2017 In addition, ORMDL3 mediated uric acid release, another marker of cellular stress. Uric Acid 29-38 ORM1-like 3 (S. cerevisiae) Mus musculus 13-19
28451452-6 2017 Multivariable adjusted Cox proportional hazards models showed that uric acid predicted all-cause mortality in subjects with E/A ratio <0.75 (HR 1.12, 95% confidence interval [CI] 1.00-1.25) or E/A ratio >1.5 (HR 1.51, 95% CI 1.09-2.09, P for interaction between E/A ratio category and uric acid = 0.02). Uric Acid 67-76 cytochrome c oxidase subunit 8A Homo sapiens 23-26
27474828-4 2017 Finally, uric acid enhanced the generation of 4-hydroxynonenal and the expression of PPARbeta/delta promoted by amyloid beta, indicating a prooxidant effects. Uric Acid 9-18 peroxisome proliferator activated receptor delta Homo sapiens 85-93
28355168-8 2017 RESULTS: In multivariable analysis, uric acid (per SD of 38 mumol/l) was associated with DBP z-scores [sbeta 0.07; confidence interval (CI), 0.01-1.14], but not with SBP z-scores. Uric Acid 36-45 selenium binding protein 1 Homo sapiens 166-169
28355168-10 2017 CONCLUSION: In school-age children, uric acid and the ratios of uric acid/xanthine and xanthine/hypoxanthine were significantly associated with DBP z-scores. Uric Acid 36-45 D-box binding PAR bZIP transcription factor Homo sapiens 144-147
28355168-10 2017 CONCLUSION: In school-age children, uric acid and the ratios of uric acid/xanthine and xanthine/hypoxanthine were significantly associated with DBP z-scores. Uric Acid 64-73 D-box binding PAR bZIP transcription factor Homo sapiens 144-147
28403945-1 2017 BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Uric Acid 89-98 xanthine dehydrogenase Homo sapiens 32-55
27659401-4 2017 The aim of this study was to examine the relationship between the serum uric acid and serum ferritin levels in a cohort of hemochromatosis patients who were homozygous for the HFE p.Cys282Tyr mutation. Uric Acid 72-81 homeostatic iron regulator Homo sapiens 176-179
27659401-12 2017 The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid. Uric Acid 16-25 transferrin Homo sapiens 120-131
27659401-12 2017 The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid. Uric Acid 204-213 transferrin Homo sapiens 120-131
28403945-11 2017 CONCLUSIONS: The present study has shown that XOR activity is correlated with serum UA levels in humans. Uric Acid 84-86 xanthine dehydrogenase Homo sapiens 46-49
28489802-8 2017 In men, however, the development of diabetes was not significantly different among the quartiles of UA.GGT and UA levels can synergize in predicting the development of diabetes in Korean women. Uric Acid 100-102 gamma-glutamyltransferase light chain family member 3 Homo sapiens 103-106
28403945-1 2017 BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Uric Acid 89-98 xanthine dehydrogenase Homo sapiens 57-60
28403945-1 2017 BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Uric Acid 100-102 xanthine dehydrogenase Homo sapiens 32-55
28403945-1 2017 BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Uric Acid 100-102 xanthine dehydrogenase Homo sapiens 57-60
28403945-2 2017 Besides the synthesis of UA, basic research has suggested that XOR is involved in the regulation of reactive oxygen species, adipogenesis, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Uric Acid 25-27 xanthine dehydrogenase Homo sapiens 63-66
28403945-2 2017 Besides the synthesis of UA, basic research has suggested that XOR is involved in the regulation of reactive oxygen species, adipogenesis, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Uric Acid 25-27 peroxisome proliferator activated receptor gamma Homo sapiens 143-191
28461764-1 2017 As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid transporter. Uric Acid 137-142 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 82-105
28455534-3 2017 In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Uric Acid 138-147 xanthine dehydrogenase Mus musculus 86-89
28455534-3 2017 In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Uric Acid 149-151 xanthine dehydrogenase Mus musculus 86-89
30603346-5 2017 The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching. Uric Acid 36-45 epidermal growth factor receptor Homo sapiens 169-173
30603346-5 2017 The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching. Uric Acid 36-45 epidermal growth factor receptor Homo sapiens 169-173
28461764-1 2017 As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid transporter. Uric Acid 137-142 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 107-112
28461764-1 2017 As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide association study, it was revealed that ABCG2 is an important uric acid transporter. Uric Acid 137-142 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 214-219
28461764-3 2017 The 141K ABCG2 urate-increasing variant causes instability in the nucleotide-binding domain, leading to decreased surface expression and function. Uric Acid 15-20 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 9-14
27979268-3 2017 The Cu-NGr composite was prepared by one pot synthesis from a mixture of graphene oxide, copper nitrate and uric acid, followed by thermal annealing at 900 C for 1h. Uric Acid 108-117 reticulon 4 receptor Homo sapiens 7-10
28389481-1 2017 OBJECTIVES: Uric acid (UA) is the product of purine or nucleotide metabolism via the pathway of xanthine oxidase or xanthine dehydrogenase. Uric Acid 12-21 xanthine dehydrogenase Homo sapiens 116-138
28951782-2 2017 The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide. Uric Acid 114-123 solute carrier family 2 member 9 Homo sapiens 60-66
28951782-2 2017 The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide. Uric Acid 114-123 solute carrier family 22 member 11 Homo sapiens 70-78
28951782-8 2017 The presence of the urate-lowering and gout-protective alleles for SLC2A9 (rs11942223 and rs13129697) and SLC22A11 (rs207826) did not significantly alter the FEUA following a frusemide load. Uric Acid 20-25 solute carrier family 2 member 9 Homo sapiens 67-73
28951782-8 2017 The presence of the urate-lowering and gout-protective alleles for SLC2A9 (rs11942223 and rs13129697) and SLC22A11 (rs207826) did not significantly alter the FEUA following a frusemide load. Uric Acid 20-25 solute carrier family 22 member 11 Homo sapiens 106-114
28287081-3 2017 By depositing a top layer of glucose oxidase or uricase, we were able to detect glucose or uric acid with limits of detection of 3.4 and 0.27 mumol l-1, respectively. Uric Acid 91-100 urate oxidase (pseudogene) Homo sapiens 48-55
28389481-1 2017 OBJECTIVES: Uric acid (UA) is the product of purine or nucleotide metabolism via the pathway of xanthine oxidase or xanthine dehydrogenase. Uric Acid 23-25 xanthine dehydrogenase Homo sapiens 116-138
27339448-8 2017 One example is that the intestinal ABCG2 may play a compensatory role at face of decreased renal clearance of UA in nephrectomized rats, the trigger of which is not a uremic toxin but SUA itself. Uric Acid 110-112 ATP binding cassette subfamily G member 2 Rattus norvegicus 35-40
28388410-0 2017 Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Uric Acid 59-68 uridine monophosphate synthetase Homo sapiens 99-111
28388410-5 2017 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS) and consequently reduces the sensitivity of cancer cells to the chemotherapeutic agent 5-fluorouracil. Uric Acid 13-22 uridine monophosphate synthetase Homo sapiens 41-71
28388410-5 2017 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS) and consequently reduces the sensitivity of cancer cells to the chemotherapeutic agent 5-fluorouracil. Uric Acid 13-22 uridine monophosphate synthetase Homo sapiens 73-77
28386072-1 2017 Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Uric Acid 33-38 solute carrier family 22 member 12 Homo sapiens 115-120
28386072-4 2017 High affinity inhibition of uric acid transport requires URAT1 residues Cys-32, Ser-35, Phe-365 and Ile-481. Uric Acid 28-37 solute carrier family 22 member 12 Homo sapiens 57-62
28386072-9 2017 Overall, our results suggest that URAT1 inhibitors bind to a common site in the core of the transporter and sterically hinder the transit of uric acid through the substrate channel, albeit with vastly different potencies and with differential interactions with specific URAT1 amino acids. Uric Acid 141-150 solute carrier family 22 member 12 Homo sapiens 34-39
28386072-9 2017 Overall, our results suggest that URAT1 inhibitors bind to a common site in the core of the transporter and sterically hinder the transit of uric acid through the substrate channel, albeit with vastly different potencies and with differential interactions with specific URAT1 amino acids. Uric Acid 141-150 solute carrier family 22 member 12 Homo sapiens 270-275
28376889-3 2017 The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production. Uric Acid 14-30 NLR family, pyrin domain containing 3 Mus musculus 126-131
28376889-3 2017 The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production. Uric Acid 14-30 interleukin 1 beta Mus musculus 165-187
28376889-3 2017 The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production. Uric Acid 32-35 NLR family, pyrin domain containing 3 Mus musculus 126-131
28376889-3 2017 The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production. Uric Acid 32-35 interleukin 1 beta Mus musculus 165-187
28376889-12 2017 Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta. Uric Acid 28-31 NLR family, pyrin domain containing 3 Mus musculus 58-63
28376889-12 2017 Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta. Uric Acid 28-31 interleukin 1 beta Mus musculus 93-101
28597803-11 2017 In addition, the multivariate COX regression model showed that the highest tertile of galectin-3 was associated with an increased risk for MACE (HR =2.13, 95% confidence interval: 1.24-3.68, P = 0.006), compared with the lowest tertile after adjustment for age, NT-proBNP, creatinine, uric acid, albumin, haemoglobin, and estimated glomerular filtration rate (eGFR). Uric Acid 285-294 galectin 3 Homo sapiens 86-96
28444472-5 2017 Metabolic benefits are also attributed to SGLT-2 inhibitors with a modest but consistent body weight decrease recorded along with improvements in lipid profile and uric acid levels. Uric Acid 164-173 solute carrier family 5 member 2 Homo sapiens 42-48
28083649-10 2017 Although urate transport by GLUT9 could be shown, neither fructose nor glucose transport was detectable. Uric Acid 9-14 solute carrier family 2 member 9 Homo sapiens 28-33
28492722-8 2017 The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance. Uric Acid 61-70 insulin Homo sapiens 97-104
27819144-5 2017 SGLT2 inhibitors can decrease blood pressure levels and serum uric acid levels and may also reduce the degree of diabetes-related albuminuria. Uric Acid 62-71 solute carrier family 5 member 2 Homo sapiens 0-5
27400779-0 2017 Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRbeta. Uric Acid 0-9 mitogen activated protein kinase 14 Rattus norvegicus 102-110
28251649-6 2017 The reduction to 1% in oxygen supply (2 h) to cells decreased the levels of released PNP, leading to an increased presence of extracellular nucleosides and to a reduced formation of xanthine and uric acid. Uric Acid 195-204 purine nucleoside phosphorylase Rattus norvegicus 85-88
27400779-0 2017 Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRbeta. Uric Acid 0-9 platelet derived growth factor receptor beta Homo sapiens 128-137
27400779-4 2017 Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Uric Acid 26-35 mitogen activated protein kinase 14 Rattus norvegicus 50-58
27400779-0 2017 Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRbeta. Uric Acid 0-9 interferon induced protein 44 Homo sapiens 112-115
27400779-4 2017 Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Uric Acid 26-35 interferon induced protein 44 Homo sapiens 60-63
27400779-4 2017 Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Uric Acid 26-35 platelet derived growth factor receptor beta Homo sapiens 76-85
28260100-10 2017 However, plasma BAFF levels were positively associated with serum creatinine, proteinuria, uric acid and group A Streptococcus infection index in patients with IgAN. Uric Acid 91-100 TNF superfamily member 13b Homo sapiens 16-20
27400779-5 2017 Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. Uric Acid 147-156 angiotensinogen Homo sapiens 41-55
27400779-5 2017 Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. Uric Acid 147-156 angiotensin II receptor type 1 Homo sapiens 73-77
27400779-5 2017 Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. Uric Acid 147-156 mitogen activated protein kinase 14 Rattus norvegicus 109-117
27400779-5 2017 Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. Uric Acid 147-156 interferon induced protein 44 Homo sapiens 122-125
27400779-6 2017 The stimulatory effect of uric acid on p38 MAPK was higher compared to that of Ang II. Uric Acid 26-35 mitogen activated protein kinase 14 Rattus norvegicus 39-47
27400779-7 2017 The results of this study show for the first time that uric acid-induced PDGFRbeta phosphorylation plays a crucial role in the development of CVDs and that elevated uric acid levels could be a potential therapeutical target in CVD patients. Uric Acid 55-64 platelet derived growth factor receptor beta Homo sapiens 73-82
28790542-7 2017 Uric acid correlated significantly with cTnI, moderate positively in the group A (rho=0.358, p=0.038) and moderate negatively in the group B (r=-0.309, p=0.037) of ACS patients. Uric Acid 0-9 troponin I3, cardiac type Homo sapiens 40-44
28152396-0 2017 Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid. Uric Acid 174-183 insulin Homo sapiens 0-7
28274727-1 2017 BACKGROUND AND AIMS: In experimental investigations conducted in rats, raising serum uric acid (SUA) levels resulted in the stimulation of intrarenal renin expression. Uric Acid 85-94 renin Rattus norvegicus 150-155
28039413-0 2017 URAT1 inhibition by ALPK1 is associated with uric acid homeostasis. Uric Acid 45-54 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 0-5
28039413-0 2017 URAT1 inhibition by ALPK1 is associated with uric acid homeostasis. Uric Acid 45-54 alpha-kinase 1 Mus musculus 20-25
28039413-11 2017 ALPK1 might prevent the impact of urate reuptake via SLC22A12 and appeared to be negatively associated with gout. Uric Acid 34-39 alpha-kinase 1 Mus musculus 0-5
28039413-11 2017 ALPK1 might prevent the impact of urate reuptake via SLC22A12 and appeared to be negatively associated with gout. Uric Acid 34-39 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 53-61
28347282-4 2017 RESULTS: Mean UA level among the 204 patients with an eGFR level >=60 ml/min/1.73 m2 was 6.4 mg/dl compared to 7.9 mg/dl among the 100 patients with eGFR <60 (p < 0.0001). Uric Acid 14-16 epidermal growth factor receptor Homo sapiens 54-58
28358829-8 2017 Furthermore, UA levels significantly correlated with the levels of striatal DAT. Uric Acid 13-15 solute carrier family 6 member 3 Homo sapiens 76-79
28282408-1 2017 Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Uric Acid 10-19 xanthine dehydrogenase Mus musculus 43-59
28027879-0 2017 A novel mode of operation of SLC22A11: Membrane insertion of estrone sulfate versus translocation of uric acid and glutamate. Uric Acid 101-110 solute carrier family 22 member 11 Homo sapiens 29-37
28027879-3 2017 Here we scrutinized the mechanism of transport of E3S by SLC22A11 (alias OAT4), by direct comparison with uric acid (UA), an important physiological substrate. Uric Acid 106-115 solute carrier family 22 member 11 Homo sapiens 57-65
28027879-3 2017 Here we scrutinized the mechanism of transport of E3S by SLC22A11 (alias OAT4), by direct comparison with uric acid (UA), an important physiological substrate. Uric Acid 106-115 solute carrier family 22 member 11 Homo sapiens 73-77
28027879-3 2017 Here we scrutinized the mechanism of transport of E3S by SLC22A11 (alias OAT4), by direct comparison with uric acid (UA), an important physiological substrate. Uric Acid 117-119 solute carrier family 22 member 11 Homo sapiens 57-65
28027879-9 2017 These results establish that SLC22A11 provides entirely different transport mechanisms for E3S and UA. Uric Acid 99-101 solute carrier family 22 member 11 Homo sapiens 29-37
28461885-5 2017 Cox regression analysis was used to evaluate the risk of in-hospital death considering serum uric acid levels and all the comorbidities. Uric Acid 93-102 cytochrome c oxidase subunit 8A Homo sapiens 0-3
28287162-5 2017 UOX degrades hyperuricemia-causing uric acid, but also generates hydrogen peroxide raising several health concerns. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 0-3
28287162-6 2017 We successfully demonstrated that one-pot UOX-AuNP cascade systems degrade uric acid more than five times faster than UOX alone, by eliminating potentially cytotoxic hydrogen peroxide, similar to enzyme-enzyme reactions. Uric Acid 75-84 urate oxidase (pseudogene) Homo sapiens 42-45
28287162-6 2017 We successfully demonstrated that one-pot UOX-AuNP cascade systems degrade uric acid more than five times faster than UOX alone, by eliminating potentially cytotoxic hydrogen peroxide, similar to enzyme-enzyme reactions. Uric Acid 75-84 urate oxidase (pseudogene) Homo sapiens 118-121
28282408-1 2017 Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Uric Acid 10-19 xanthine dehydrogenase Mus musculus 61-63
28282408-1 2017 Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Uric Acid 170-175 xanthine dehydrogenase Mus musculus 43-59
28282408-1 2017 Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Uric Acid 170-175 xanthine dehydrogenase Mus musculus 61-63
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 tripartite motif containing 46 Homo sapiens 24-30
27915157-8 2017 Under the selected optimum conditions, the obtained analytical signals were linear in the ranges of 0.50-5.00 and 0.50-4.00mgL-1 for AA and UA, respectively. Uric Acid 140-142 LLGL scribble cell polarity complex component 1 Homo sapiens 123-128
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 PDZ domain containing 1 Homo sapiens 11-16
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 hepatocyte nuclear factor 4 gamma Homo sapiens 32-37
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 glucokinase regulator Homo sapiens 18-22
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 solute carrier family 17 member 1 Homo sapiens 39-46
28252667-4 2017 Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. Uric Acid 101-106 capping protein regulator and myosin 1 linker 1 Homo sapiens 48-55
27977314-7 2017 In addition, SGLT-2 inhibitors have shown reductions in albuminuria, uric acid, and an increase in magnesium. Uric Acid 69-78 solute carrier family 5 member 2 Homo sapiens 13-19
27614971-10 2017 Additionally, hOATv1 functions as a common renal secretory pathway for both urate and drugs, indicating that hOATv1 may be a leak pathway for excess urate that is reabsorbed via apical URAT1 to control the intracellular urate levels. Uric Acid 76-81 solute carrier family 22 member 12 Homo sapiens 185-190
27614971-10 2017 Additionally, hOATv1 functions as a common renal secretory pathway for both urate and drugs, indicating that hOATv1 may be a leak pathway for excess urate that is reabsorbed via apical URAT1 to control the intracellular urate levels. Uric Acid 149-154 solute carrier family 22 member 12 Homo sapiens 185-190
27614971-10 2017 Additionally, hOATv1 functions as a common renal secretory pathway for both urate and drugs, indicating that hOATv1 may be a leak pathway for excess urate that is reabsorbed via apical URAT1 to control the intracellular urate levels. Uric Acid 149-154 solute carrier family 22 member 12 Homo sapiens 185-190
28270201-11 2017 Proof of principle for use of EHRs was verification of the highly significant association of urate levels with the well-established urate transporter SLC2A9. Uric Acid 93-98 solute carrier family 2 member 9 Homo sapiens 150-156
28270222-12 2017 The ABCG2 associations persisted in the Western Polynesian group after adjusting for serum urate, creatinine, and disease duration, and when including both ABCG2 variants in the regression models. Uric Acid 91-96 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 4-9
28271689-8 2017 MRA demonstrated that serum CysC levels correlated significantly with serum creatinine (Cr), high density lipoprotein (HDL-C), alkaline phosphatase (ALP), albumin (ALB), and uric acid (UA) concentrations, although their relationships were less prominent than those of gender or age. Uric Acid 174-183 cystatin C Homo sapiens 28-32
28271689-8 2017 MRA demonstrated that serum CysC levels correlated significantly with serum creatinine (Cr), high density lipoprotein (HDL-C), alkaline phosphatase (ALP), albumin (ALB), and uric acid (UA) concentrations, although their relationships were less prominent than those of gender or age. Uric Acid 185-187 cystatin C Homo sapiens 28-32
27898524-5 2017 Greater uromodulin excretion is associated with markers of volume overload such as fractional excretion of uric acid, sodium and chloride, indicating a possible role in salt and water retention. Uric Acid 107-116 uromodulin Homo sapiens 8-18
28129213-7 2017 Patients with uric acid values of at least 6 mg/dl (prevalence of 14.6%) had significantly lower levels of high-density lipoprotein cholesterol and increased values of BMI, blood pressure (BP), cholesterol, triglycerides, white blood cells, complement component 3 (C3) and creatinine. Uric Acid 14-23 complement C3 Homo sapiens 265-267
27853847-0 2017 Macrophage-derived IL-1beta enhances monosodium urate crystal-triggered NET formation. Uric Acid 37-53 interleukin 1 beta Homo sapiens 19-27
28176796-7 2017 Observed results about prevention of experimental diabetes in DP pretreated groups may suggest that purine compounds, uric acid and other volatile toxic compounds of commercial milk may suppress oral tolerance, probably via IL-6 and TGF-beta cytokine effects. Uric Acid 118-127 interleukin 6 Rattus norvegicus 224-228
27988213-0 2017 Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Uric Acid 28-33 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 19-24
27988213-0 2017 Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Uric Acid 28-33 parathyroid hormone Homo sapiens 47-66
27988213-2 2017 However, the molecular mechanism by which the serum parathyroid hormone (PTH) affects serum urate levels remains unknown. Uric Acid 92-97 parathyroid hormone Homo sapiens 52-71
27988213-2 2017 However, the molecular mechanism by which the serum parathyroid hormone (PTH) affects serum urate levels remains unknown. Uric Acid 92-97 parathyroid hormone Homo sapiens 73-76
28038936-6 2017 Significant positive correlations were found between circulating nesfatin-1 levels and the following case-mix variables: duration of diabetes, glycated hemoglobin, plasma creatinine, UAE and serum uric acid. Uric Acid 197-206 nucleobindin 2 Homo sapiens 65-75
28394398-9 2017 Expression of PPARGC1B and NLRP3 was induced in urate crystal-activated THP-1, peripheral blood mononuclear cells and synovial cells from gout patients in acute stage. Uric Acid 48-53 PPARG coactivator 1 beta Homo sapiens 14-22
28394398-9 2017 Expression of PPARGC1B and NLRP3 was induced in urate crystal-activated THP-1, peripheral blood mononuclear cells and synovial cells from gout patients in acute stage. Uric Acid 48-53 NLR family pyrin domain containing 3 Homo sapiens 27-32
28394398-9 2017 Expression of PPARGC1B and NLRP3 was induced in urate crystal-activated THP-1, peripheral blood mononuclear cells and synovial cells from gout patients in acute stage. Uric Acid 48-53 GLI family zinc finger 2 Homo sapiens 72-77
28394398-10 2017 siRNA knockdown of PPARGC1B upregulated NLRP3 in urate crystal-activated macrophages. Uric Acid 49-54 PPARG coactivator 1 beta Homo sapiens 19-27
28394398-10 2017 siRNA knockdown of PPARGC1B upregulated NLRP3 in urate crystal-activated macrophages. Uric Acid 49-54 NLR family pyrin domain containing 3 Homo sapiens 40-45
27771328-6 2017 Suppression of DNA degradation by the deletion of DNase2 resulted in aberrantly increased concentrations of residual DNA and decreased amounts of the DNA metabolite uric acid in secreted sebum. Uric Acid 165-174 deoxyribonuclease II alpha Mus musculus 50-56
28762935-9 2017 Correlation analysis also revealed close and moderate correlations between galectin-3 and cystatin-C, glomerular filtration rate, and uric acid. Uric Acid 134-143 galectin 3 Homo sapiens 75-85
28523032-12 2017 We found a significant correlation between uric acid level and BNP (p= <0.001), and use of diuretics (p=<0.001). Uric Acid 43-52 natriuretic peptide B Homo sapiens 63-66
28052039-5 2017 Interestingly, UA-induced cell proliferation was accompanied with the upregulation of COX-2 and mPGES-1 at both mRNA and protein levels. Uric Acid 15-17 prostaglandin E synthase Mus musculus 96-103
28052039-6 2017 Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation. Uric Acid 87-89 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31
28052039-0 2017 COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation. Uric Acid 47-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5
28052039-6 2017 Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation. Uric Acid 87-89 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52
28052039-0 2017 COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation. Uric Acid 47-56 prostaglandin E synthase Mus musculus 6-13
28052039-8 2017 Furthermore, inhibiting mPGES-1 by a siRNA approach in MCs also ameliorated UA-induced MC proliferation in line with a significant blockade of PGE2 secretion. Uric Acid 76-78 prostaglandin E synthase Mus musculus 24-31
28052039-3 2017 The present study was undertaken to examined the role of inflammatory cascade of COX-2/mPGES-1/PGE2 in UA-induced MC proliferation. Uric Acid 103-105 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86
28052039-10 2017 In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation. Uric Acid 90-92 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48
28052039-3 2017 The present study was undertaken to examined the role of inflammatory cascade of COX-2/mPGES-1/PGE2 in UA-induced MC proliferation. Uric Acid 103-105 prostaglandin E synthase Mus musculus 87-94
28052039-10 2017 In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation. Uric Acid 90-92 prostaglandin E synthase Mus musculus 49-56
28052039-4 2017 In the dose- and time-dependent experiments, UA increased cell proliferation shown by the increased total cell number, DNA synthesis rate, and the number of cells in S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1. Uric Acid 45-47 cyclin A2 Homo sapiens 219-228
28357121-8 2017 Notably, while benzbromarone and probenecid inhibited urate as well as nicotinate transport, tranilast inhibited the urate transport function of URAT1, GLUT9, OAT4, OAT10, and NPT1, without significantly affecting nicotinate transport mediated by SMCT1 (IC 50 ~1.1 mmol/L), SMCT2 (IC 50 ~1.0 mmol/L), and URAT1 (IC 50 ~178 mumol/L). Uric Acid 117-122 solute carrier family 22 member 12 Homo sapiens 145-150
28052039-4 2017 In the dose- and time-dependent experiments, UA increased cell proliferation shown by the increased total cell number, DNA synthesis rate, and the number of cells in S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1. Uric Acid 45-47 cyclin D1 Homo sapiens 233-242
28052039-5 2017 Interestingly, UA-induced cell proliferation was accompanied with the upregulation of COX-2 and mPGES-1 at both mRNA and protein levels. Uric Acid 15-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 86-91
28357121-5 2017 We report here that tranilast is a potent inhibitor of [14C]-urate transport mediated by the major reabsorptive urate transporters (URAT1, GLUT9, OAT4, and OAT10) in Xenopus oocytes; this provides an unequivocal molecular mechanism for the drug"s uricosuric effect. Uric Acid 61-66 solute carrier family 22 member 12 Homo sapiens 132-137
28357121-5 2017 We report here that tranilast is a potent inhibitor of [14C]-urate transport mediated by the major reabsorptive urate transporters (URAT1, GLUT9, OAT4, and OAT10) in Xenopus oocytes; this provides an unequivocal molecular mechanism for the drug"s uricosuric effect. Uric Acid 61-66 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 139-144
28357121-5 2017 We report here that tranilast is a potent inhibitor of [14C]-urate transport mediated by the major reabsorptive urate transporters (URAT1, GLUT9, OAT4, and OAT10) in Xenopus oocytes; this provides an unequivocal molecular mechanism for the drug"s uricosuric effect. Uric Acid 61-66 solute carrier family 22 member 11 Homo sapiens 146-150
27866054-9 2017 A significant positive correlation was seen between the cTnI and miR-499 (r~0.53, P<0.01) and between miR-126 and UA (r~0.5, P<0.01). Uric Acid 117-119 microRNA 126 Homo sapiens 105-112
28084571-16 2017 Uric acid formed from xanthine-xanthine oxidase interaction stimulates CD36 expression and triggers foam cell formation independent of NLRP3 activation. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 135-140
28357121-5 2017 We report here that tranilast is a potent inhibitor of [14C]-urate transport mediated by the major reabsorptive urate transporters (URAT1, GLUT9, OAT4, and OAT10) in Xenopus oocytes; this provides an unequivocal molecular mechanism for the drug"s uricosuric effect. Uric Acid 61-66 solute carrier family 22 member 13 S homeolog Xenopus laevis 156-161
28357121-6 2017 Tranilast was found to inhibit urate transport mediated by URAT1 and GLUT9 in a fully reversible and noncompetitive (mixed) manner. Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 59-64
28357121-6 2017 Tranilast was found to inhibit urate transport mediated by URAT1 and GLUT9 in a fully reversible and noncompetitive (mixed) manner. Uric Acid 31-36 solute carrier family 2 member 9 Homo sapiens 69-74
28084571-4 2017 This study was designed to study the role of various scavenger receptors and NLRP3 inflammasome in xanthine oxidase and uric acid-induced foam cell formation. Uric Acid 120-129 NLR family pyrin domain containing 3 Homo sapiens 77-82
28084571-5 2017 METHODS AND RESULTS: Human vascular smooth muscle cells (VSMCs) and THP-1 macrophages were treated with xanthine oxidase or uric acid. Uric Acid 124-133 GLI family zinc finger 2 Homo sapiens 68-73
27993957-7 2017 In cultured human kidney 2 cells, both fructose and uric acid increased protein expression of soluble PRR in a time- and dose-dependent manner; fructose-induced PRR upregulation was inhibited by allopurinol. Uric Acid 52-61 ATPase H+ transporting accessory protein 2 Homo sapiens 102-105
28105870-0 2017 Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women. Uric Acid 21-30 C-reactive protein Homo sapiens 53-71
28105870-1 2017 OBJECTIVES: To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women. Uric Acid 65-74 C-reactive protein Homo sapiens 132-150
27993957-8 2017 Taken together, our data suggest that fructose via uric acid stimulates renal expression of PRR/soluble PRR that stimulate sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter expression and intrarenal renin-angiotensin system to induce salt-sensitive hypertension. Uric Acid 51-60 ATPase H+ transporting accessory protein 2 Homo sapiens 92-95
27993957-7 2017 In cultured human kidney 2 cells, both fructose and uric acid increased protein expression of soluble PRR in a time- and dose-dependent manner; fructose-induced PRR upregulation was inhibited by allopurinol. Uric Acid 52-61 ATPase H+ transporting accessory protein 2 Homo sapiens 161-164
27993957-8 2017 Taken together, our data suggest that fructose via uric acid stimulates renal expression of PRR/soluble PRR that stimulate sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter expression and intrarenal renin-angiotensin system to induce salt-sensitive hypertension. Uric Acid 51-60 ATPase H+ transporting accessory protein 2 Homo sapiens 104-107
28117388-0 2017 Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9). Uric Acid 35-40 solute carrier family 2 member 9 Homo sapiens 92-99
27993957-8 2017 Taken together, our data suggest that fructose via uric acid stimulates renal expression of PRR/soluble PRR that stimulate sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter expression and intrarenal renin-angiotensin system to induce salt-sensitive hypertension. Uric Acid 51-60 renin Homo sapiens 204-209
27987663-7 2017 In addition, the PA/GO/GCE demonstrated high electrochemical selectivity toward DA in the presence of ascorbic acid (AA) and uric acid (UA). Uric Acid 125-134 aminomethyltransferase Homo sapiens 17-26
27987663-7 2017 In addition, the PA/GO/GCE demonstrated high electrochemical selectivity toward DA in the presence of ascorbic acid (AA) and uric acid (UA). Uric Acid 136-138 aminomethyltransferase Homo sapiens 17-26
27865177-2 2017 Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. Uric Acid 103-112 xanthine dehydrogenase Homo sapiens 0-23
27865177-2 2017 Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. Uric Acid 103-112 xanthine dehydrogenase Homo sapiens 25-28
27865177-2 2017 Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. Uric Acid 114-116 xanthine dehydrogenase Homo sapiens 0-23
27865177-2 2017 Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. Uric Acid 114-116 xanthine dehydrogenase Homo sapiens 25-28
28147282-3 2017 Through an extracellular alpha-helix, both mouse and human SR-B1 specifically recognized amorphous and crystalline silica, but not titanium dioxide nanoparticles, latex nanoparticles, or monosodium urate crystals, although all particles exhibited negative surface potentials. Uric Acid 187-203 scavenger receptor class B member 1 Homo sapiens 59-64
27973769-6 2017 The uric acid in human tears was quantitatively detected at physiological levels (25-150 muM) by using SERS. Uric Acid 4-13 latexin Homo sapiens 89-92
28117388-1 2017 Human glucose transporter 9 (hSLC2A9) is critical in human urate homeostasis, for which very small deviations can lead to chronic or acute metabolic disorders. Uric Acid 59-64 solute carrier family 2 member 9 Homo sapiens 29-36
28167912-0 2017 C5a Regulates IL-1beta Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis. Uric Acid 81-97 hemolytic complement Mus musculus 0-3
28117388-2 2017 Human SLC2A9 is unique in that it transports hexoses as well as the organic anion, urate. Uric Acid 83-88 solute carrier family 2 member 9 Homo sapiens 6-12
28117388-4 2017 Our in silico substrate docking study has revealed that urate and fructose bind within the same binding pocket in hSLC2A9, yet with distinct orientations, and allowed us to identify novel residues for urate binding. Uric Acid 56-61 solute carrier family 2 member 9 Homo sapiens 114-121
28117388-4 2017 Our in silico substrate docking study has revealed that urate and fructose bind within the same binding pocket in hSLC2A9, yet with distinct orientations, and allowed us to identify novel residues for urate binding. Uric Acid 201-206 solute carrier family 2 member 9 Homo sapiens 114-121
28117388-6 2017 We have shown that cysteine residues, C181, C301 and C459 in hSLC2A9 are also essential elements for mediating urate transport. Uric Acid 111-116 solute carrier family 2 member 9 Homo sapiens 61-68
28117388-7 2017 Additional data from chimaeric protein analysis illustrated that transmembrane helix 7 of hSLC2A9 is necessary for urate transport but not sufficient to allow urate transport to be induced in glucose transporter 5 (hSLC2A5). Uric Acid 115-120 solute carrier family 2 member 9 Homo sapiens 90-97
28117388-8 2017 These data indicate that urate transport in hSLC2A9 involves several structural elements rather than just a unique substrate binding pocket. Uric Acid 25-30 solute carrier family 2 member 9 Homo sapiens 44-51
28057038-0 2017 Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations. Uric Acid 71-80 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 0-16
28105014-11 2016 Uric acid levels significantly rose with body mass index (BMI), waist circumference (WC), triglyceride (TG) levels, triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), insulin levels, homeostatic model assessment index (HOMA-IR), high-sensitivity CRP (hs-CRP) levels, and leptin levels. Uric Acid 0-9 insulin Homo sapiens 188-195
28095793-8 2017 We observed a strong association (p < 8 x 10-8) of uric acid clearance with a single nucleotide polymorphism (SNP) in zinc finger protein 446 (ZNF446) (rs2033711 (A/G), MAF: 0.30). Uric Acid 54-63 zinc finger protein 446 Homo sapiens 121-144
28095793-8 2017 We observed a strong association (p < 8 x 10-8) of uric acid clearance with a single nucleotide polymorphism (SNP) in zinc finger protein 446 (ZNF446) (rs2033711 (A/G), MAF: 0.30). Uric Acid 54-63 zinc finger protein 446 Homo sapiens 146-152
28095793-8 2017 We observed a strong association (p < 8 x 10-8) of uric acid clearance with a single nucleotide polymorphism (SNP) in zinc finger protein 446 (ZNF446) (rs2033711 (A/G), MAF: 0.30). Uric Acid 54-63 MAF bZIP transcription factor Homo sapiens 172-175
28095793-10 2017 Also, we found suggestive associations of uric acid clearance with SNPs in ZNF324, ZNF584, and ZNF132 (in a 72 kb region of 19q13; p <1 x 10-6, MAFs: 0.28-0.31). Uric Acid 42-51 zinc finger protein 324 Homo sapiens 75-81
28095793-10 2017 Also, we found suggestive associations of uric acid clearance with SNPs in ZNF324, ZNF584, and ZNF132 (in a 72 kb region of 19q13; p <1 x 10-6, MAFs: 0.28-0.31). Uric Acid 42-51 zinc finger protein 584 Homo sapiens 83-89
28095793-10 2017 Also, we found suggestive associations of uric acid clearance with SNPs in ZNF324, ZNF584, and ZNF132 (in a 72 kb region of 19q13; p <1 x 10-6, MAFs: 0.28-0.31). Uric Acid 42-51 zinc finger protein 132 Homo sapiens 95-101
28105014-12 2016 Conversely, the levels of HDL-C and adiponectin were negatively correlated with uric acid levels. Uric Acid 80-89 adiponectin, C1Q and collagen domain containing Homo sapiens 36-47
28105014-13 2016 In multiple regression analysis, there were age, BMI, TG/HDL-C ratio, and adiponectin levels remained significantly associated with uric acid levels. Uric Acid 132-141 adiponectin, C1Q and collagen domain containing Homo sapiens 74-85
28057038-8 2017 RESULTS: Increased AR expression in high UA-treated endothelial cells enhanced ROS production by activating NADPH oxidase. Uric Acid 41-43 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 19-21
28057038-13 2017 CONCLUSIONS: Our findings indicate that inhibiting AR or degrading H2O2 could protect endothelial function and maintain the antioxidant activities of UA. Uric Acid 150-152 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 51-53
28340987-3 2017 More importantly, some of them exhibited proved efficient effects on inhibiting XOD activity and suppressing uptake of uric acid via URAT1 in vitro. Uric Acid 119-128 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 133-138
28116308-0 2017 Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway. Uric Acid 0-9 high mobility group box 1 Homo sapiens 60-65
28116308-0 2017 Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway. Uric Acid 0-9 advanced glycosylation end-product specific receptor Homo sapiens 66-70
29017152-0 2017 High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway. Uric Acid 5-14 toll like receptor 4 Homo sapiens 99-103
29017152-4 2017 However, whether TLR4/NF-kappaB signaling pathway is also involved in EMT of renal tubular cells induced by UA is not clear. Uric Acid 108-110 toll like receptor 4 Homo sapiens 17-21
29017152-6 2017 The activation of the TLR4/NF-kappaB signaling pathway induced by UA was measured by Western blot and its involvement was further confirmed by the inhibition of NF-kappaB activation or knockdown of toll like receptor 4 (TLR4) expression. Uric Acid 66-68 toll like receptor 4 Homo sapiens 22-26
29017152-6 2017 The activation of the TLR4/NF-kappaB signaling pathway induced by UA was measured by Western blot and its involvement was further confirmed by the inhibition of NF-kappaB activation or knockdown of toll like receptor 4 (TLR4) expression. Uric Acid 66-68 toll like receptor 4 Homo sapiens 198-218
29017152-6 2017 The activation of the TLR4/NF-kappaB signaling pathway induced by UA was measured by Western blot and its involvement was further confirmed by the inhibition of NF-kappaB activation or knockdown of toll like receptor 4 (TLR4) expression. Uric Acid 66-68 toll like receptor 4 Homo sapiens 220-224
29017152-7 2017 RESULTS: UA induced obvious morphological changes of HK-2 cell, accompanied with altered molecular markers of EMT including fibronectin, alpha-SMA and E-cadherin. Uric Acid 9-11 fibronectin 1 Homo sapiens 124-135
29017152-7 2017 RESULTS: UA induced obvious morphological changes of HK-2 cell, accompanied with altered molecular markers of EMT including fibronectin, alpha-SMA and E-cadherin. Uric Acid 9-11 cadherin 1 Homo sapiens 151-161
29017152-8 2017 In addition, UA significantly upregulated the gene expression of interleukin-1beta and tumor necrosis factor-alpha in a time- and dose-dependent manner. Uric Acid 13-15 interleukin 1 beta Homo sapiens 65-114
29017152-9 2017 Furthermore, UA significantly activated the TLR4/NF-kappaB signaling pathway in HK-2 cells, while the inhibition of the TLR4 expression by siRNA and NF-kappaB activation by PDTC significantly attenuated EMT induced by UA in HK-2 cells. Uric Acid 13-15 toll like receptor 4 Homo sapiens 44-48
29017152-9 2017 Furthermore, UA significantly activated the TLR4/NF-kappaB signaling pathway in HK-2 cells, while the inhibition of the TLR4 expression by siRNA and NF-kappaB activation by PDTC significantly attenuated EMT induced by UA in HK-2 cells. Uric Acid 218-220 toll like receptor 4 Homo sapiens 120-124
29017152-10 2017 CONCLUSIONS: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF-kappaB signaling pathway, and the targeted intervention of the TLR4/NF-kappaB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT. Uric Acid 13-15 toll like receptor 4 Homo sapiens 90-94
29017152-10 2017 CONCLUSIONS: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF-kappaB signaling pathway, and the targeted intervention of the TLR4/NF-kappaB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT. Uric Acid 13-15 toll like receptor 4 Homo sapiens 161-165
29017152-10 2017 CONCLUSIONS: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF-kappaB signaling pathway, and the targeted intervention of the TLR4/NF-kappaB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT. Uric Acid 220-222 toll like receptor 4 Homo sapiens 161-165
28116308-2 2017 UA increases high mobility group box chromosomal protein 1 (HMGB1) expression and extracellular release in endothelial cells. Uric Acid 0-2 structure specific recognition protein 1 Homo sapiens 13-36
28116308-2 2017 UA increases high mobility group box chromosomal protein 1 (HMGB1) expression and extracellular release in endothelial cells. Uric Acid 0-2 high mobility group box 1 Homo sapiens 60-65
28116308-5 2017 UA inhibited endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in HUVECs, increased intracellular HMGB1 expression and extracellular HMGB1 secretion, and upregulated RAGE expression. Uric Acid 0-2 nitric oxide synthase 3 Homo sapiens 13-46
28116308-5 2017 UA inhibited endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in HUVECs, increased intracellular HMGB1 expression and extracellular HMGB1 secretion, and upregulated RAGE expression. Uric Acid 0-2 high mobility group box 1 Homo sapiens 133-138
28116308-5 2017 UA inhibited endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in HUVECs, increased intracellular HMGB1 expression and extracellular HMGB1 secretion, and upregulated RAGE expression. Uric Acid 0-2 high mobility group box 1 Homo sapiens 168-173
28116308-5 2017 UA inhibited endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in HUVECs, increased intracellular HMGB1 expression and extracellular HMGB1 secretion, and upregulated RAGE expression. Uric Acid 0-2 advanced glycosylation end-product specific receptor Homo sapiens 201-205
28116308-6 2017 UA also activated NF-kappaB and increased the level of inflammatory cytokines. Uric Acid 0-2 nuclear factor kappa B subunit 1 Homo sapiens 18-27
28116308-9 2017 Our results suggest that high concentrations of UA cause endothelial dysfunction via the HMGB1/RAGE signaling pathway. Uric Acid 48-50 high mobility group box 1 Homo sapiens 89-94
26419665-1 2017 Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. Uric Acid 99-108 insulin Homo sapiens 51-58
28116308-9 2017 Our results suggest that high concentrations of UA cause endothelial dysfunction via the HMGB1/RAGE signaling pathway. Uric Acid 48-50 advanced glycosylation end-product specific receptor Homo sapiens 95-99
26419665-1 2017 Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. Uric Acid 146-155 insulin Homo sapiens 51-58
27748201-4 2017 The beneficial effects of SGLT2 inhibitors on the conventional risk factors for kidney disease (such as blood pressure, hyperglycaemia, body weight and serum uric acid levels) may explain, at least in part, the observed renal-protecting properties of these compounds. Uric Acid 158-167 solute carrier family 5 member 2 Homo sapiens 26-31
28413972-4 2017 The xanthine oxidoreductase (XOR) is an essential enzyme for the generation of uric acid. Uric Acid 79-88 xanthine dehydrogenase Homo sapiens 4-27
28413972-4 2017 The xanthine oxidoreductase (XOR) is an essential enzyme for the generation of uric acid. Uric Acid 79-88 xanthine dehydrogenase Homo sapiens 29-32
28413972-5 2017 A typical pharmacological therapy to reduce the uric acid amounts is inhibition of XOR. Uric Acid 48-57 xanthine dehydrogenase Homo sapiens 83-86
28413972-7 2017 The question arises if XOR inhibition might be an attractive target to reduce cardiovascular events in patients with high or even normal uric acid levels. Uric Acid 137-146 xanthine dehydrogenase Homo sapiens 23-26
28088910-4 2017 RESULTS: SGLT2i improve several CV risk factors, including fasting and postprandial plasma glucose levels, lipids, blood pressure, body weight, serum uric acid and arterial stiffness. Uric Acid 150-159 solute carrier family 5 member 2 Homo sapiens 9-14
28847266-0 2017 Independent Relationship between Serum Osteocalcin and Uric Acid in a Cohort of Apparently Healthy Obese Subjects. Uric Acid 55-64 bone gamma-carboxyglutamate protein Homo sapiens 39-50
28847266-7 2017 RESULTS: Serum OC was directly and independently correlated with circulating UA in our population of obese subjects, while neither BMI, age, serum lipids, fasting glycaemia nor gender showed a statistically significant correlation with endogenous plasma levels of OC. Uric Acid 77-79 bone gamma-carboxyglutamate protein Homo sapiens 15-17
28847266-8 2017 CONCLUSION: The positive effect determined by serum OC in bone metabolism of our obese subjects might be partly due to the antioxidant properties that normal plasma UA levels exert at bone tissue level. Uric Acid 165-167 bone gamma-carboxyglutamate protein Homo sapiens 52-54
27807007-1 2017 Glucose transporter (Glut) 9 plays an important role in maintaining the homeostasis of uric acid in the body. Uric Acid 87-96 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-28
29099118-5 2017 Serum uric acid levels were statistically correlated with c-LDL, total bilirubin, albumin, GGT and CRP suggesting hyperuricemia could be associated with a dyslipidemic state, hepatic damage and increase in acute pro-inflammatory phase markers. Uric Acid 6-15 C-reactive protein Homo sapiens 99-102
29099118-6 2017 In addition, a multiple linear regression analysis revealed that GGT and IL-10 were better predictors of the behavior of uric acid in the study population. Uric Acid 121-130 interleukin 10 Homo sapiens 73-78
29099118-7 2017 Conclusion: These results suggest an -interdependent relationship among serum uric acid, CRP and IL-10 levels, which could be related to early hepatic -damage. Uric Acid 78-87 interleukin 10 Homo sapiens 97-102
29337974-11 2017 Owing to high serum uric acid levels, the FRAP assay results in these patients may be overestimated despite the reduced levels of other plasma antioxidants. Uric Acid 20-29 mechanistic target of rapamycin kinase Homo sapiens 42-46
27138369-5 2017 CysC was significantly correlated with serum creatinine (r=0.473, p<0.001), and serum uric acid (SUA) (r=0.546, p<0.001). Uric Acid 89-98 cystatin C Homo sapiens 0-4
26792383-0 2017 Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population. Uric Acid 50-59 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 15-20
26792383-3 2017 Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) levels, and the degree of association between rs2231142 and hyperuricemia is affected by both sex and ethnicity. Uric Acid 159-168 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 61-66
26792383-3 2017 Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) levels, and the degree of association between rs2231142 and hyperuricemia is affected by both sex and ethnicity. Uric Acid 170-172 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 61-66
26792383-4 2017 This investigation aimed to analyze the association between ABCG2 polymorphisms and UA levels, as well as their interactions with sex and obesity in Taiwanese. Uric Acid 84-86 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 60-65
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 11-20 NLR family, pyrin domain containing 3 Rattus norvegicus 40-45
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 11-20 PYD and CARD domain containing Rattus norvegicus 46-49
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 11-20 caspase 1 Rattus norvegicus 50-59
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 22-24 NLR family, pyrin domain containing 3 Rattus norvegicus 40-45
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 22-24 PYD and CARD domain containing Rattus norvegicus 46-49
29358971-1 2017 Objective: Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury. Uric Acid 22-24 caspase 1 Rattus norvegicus 50-59
27895176-4 2017 We demonstrate that alum, as well as other sterile particulates, such as uric acid crystals, induces DCs to produce IL-2 following initiation of actin-mediated phagocytosis that leads to Src and Syk kinase activation, Ca2+ mobilization, and calcineurin-dependent activation of NFAT, the master transcription factor regulating IL-2 expression. Uric Acid 73-82 interleukin 2 Mus musculus 116-120
27895176-4 2017 We demonstrate that alum, as well as other sterile particulates, such as uric acid crystals, induces DCs to produce IL-2 following initiation of actin-mediated phagocytosis that leads to Src and Syk kinase activation, Ca2+ mobilization, and calcineurin-dependent activation of NFAT, the master transcription factor regulating IL-2 expression. Uric Acid 73-82 Rous sarcoma oncogene Mus musculus 187-190
27895176-4 2017 We demonstrate that alum, as well as other sterile particulates, such as uric acid crystals, induces DCs to produce IL-2 following initiation of actin-mediated phagocytosis that leads to Src and Syk kinase activation, Ca2+ mobilization, and calcineurin-dependent activation of NFAT, the master transcription factor regulating IL-2 expression. Uric Acid 73-82 spleen tyrosine kinase Mus musculus 195-198
27895176-4 2017 We demonstrate that alum, as well as other sterile particulates, such as uric acid crystals, induces DCs to produce IL-2 following initiation of actin-mediated phagocytosis that leads to Src and Syk kinase activation, Ca2+ mobilization, and calcineurin-dependent activation of NFAT, the master transcription factor regulating IL-2 expression. Uric Acid 73-82 interleukin 2 Mus musculus 326-330
27903742-0 2017 P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals. Uric Acid 146-162 pyrimidinergic receptor P2Y6 Homo sapiens 0-13
27903743-0 2017 Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction. Uric Acid 0-9 interleukin 1 beta Homo sapiens 87-91
27903743-4 2017 One of these damage-associated molecular patterns, uric acid, is increased in the maternal circulation in pathological pregnancies and is a known agonist of the Nlrp3 inflammasome and inducer of inflammation. Uric Acid 51-60 NLR family pyrin domain containing 3 Homo sapiens 161-166
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 14-23 interleukin 1 beta Homo sapiens 169-177
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 14-23 interleukin 6 Homo sapiens 182-186
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 25-41 interleukin 1 beta Homo sapiens 169-177
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 25-41 interleukin 6 Homo sapiens 182-186
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 43-46 interleukin 1 beta Homo sapiens 169-177
27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 43-46 interleukin 6 Homo sapiens 182-186
27838211-10 2017 SIGNIFICANCE: These results indicate that chronic alcohol administration might enhance the catabolism of purine nucleotides in tissues by inducing gene expression of ADA and XO, leading to elevation of plasma uric acid levels. Uric Acid 209-218 adenosine deaminase Rattus norvegicus 166-169
27720648-2 2016 Therefore, PDZK1 in renal proximal tubules may affect serum uric acid levels through PDZK1-binding renal urate transporters. Uric Acid 60-69 PDZ domain containing 1 Homo sapiens 11-16
27633583-2 2017 Uric acid transporter 1 (URAT1) was the promising therapeutic target for urate-lowering therapy. Uric Acid 73-78 solute carrier family 22 member 12 Homo sapiens 0-23
27633583-2 2017 Uric acid transporter 1 (URAT1) was the promising therapeutic target for urate-lowering therapy. Uric Acid 73-78 solute carrier family 22 member 12 Homo sapiens 25-30
27633583-4 2017 METHODS: The SAR of 1c was systematically explored and the in vitro URAT1 inhibitory activity of synthesized compounds 1a-1t was determined by the inhibition of URAT1-mediated [8-14C]uric acid uptake by human embryonic kidney 293 (HEK293) cells stably expressing human URAT1. Uric Acid 183-192 solute carrier family 22 member 12 Homo sapiens 68-73
27633583-4 2017 METHODS: The SAR of 1c was systematically explored and the in vitro URAT1 inhibitory activity of synthesized compounds 1a-1t was determined by the inhibition of URAT1-mediated [8-14C]uric acid uptake by human embryonic kidney 293 (HEK293) cells stably expressing human URAT1. Uric Acid 183-192 solute carrier family 22 member 12 Homo sapiens 161-166
27633583-4 2017 METHODS: The SAR of 1c was systematically explored and the in vitro URAT1 inhibitory activity of synthesized compounds 1a-1t was determined by the inhibition of URAT1-mediated [8-14C]uric acid uptake by human embryonic kidney 293 (HEK293) cells stably expressing human URAT1. Uric Acid 183-192 solute carrier family 22 member 12 Homo sapiens 161-166
28648203-9 2017 High GGT levels were associated with higher comorbidity burden, and a biochemical profile characterised by higher serum concentration of uric acid, triglycerides, alanine aminotransferase, ferritin, and C-reactive. Uric Acid 137-146 gamma-glutamyltransferase 1 Homo sapiens 5-8
29158942-0 2017 The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson"s Disease. Uric Acid 83-92 solute carrier family 2 member 9 Homo sapiens 52-58
29158942-1 2017 Individuals with Parkinson"s disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9, are associated with lower uric acid levels. Uric Acid 53-62 solute carrier family 2 member 9 Homo sapiens 188-194
29158942-1 2017 Individuals with Parkinson"s disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9, are associated with lower uric acid levels. Uric Acid 222-231 solute carrier family 2 member 9 Homo sapiens 188-194
29158942-8 2017 Thus, SLC2A9 rs1014290 is related to lower uric acid levels in PD patients and can be a risk factor for PD in the Han population. Uric Acid 43-52 solute carrier family 2 member 9 Homo sapiens 6-12
28082903-1 2016 ATP-binding cassette transporter G2 (ABCG2) is a plasma membrane protein that regulates the pharmacokinetics of a variety of drugs and serum uric acid (SUA) levels in humans. Uric Acid 141-150 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-35
28082903-1 2016 ATP-binding cassette transporter G2 (ABCG2) is a plasma membrane protein that regulates the pharmacokinetics of a variety of drugs and serum uric acid (SUA) levels in humans. Uric Acid 141-150 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 37-42
28082903-5 2016 The results of the in vitro screening showed that 10 of 25 drugs investigated strongly inhibited the urate transport activity of ABCG2. Uric Acid 101-106 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 129-134
28002433-1 2016 Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. Uric Acid 97-106 urate oxidase (pseudogene) Homo sapiens 56-63
28002433-4 2016 Treatment for severe gout includes injection of non-human uricase to reduce serum uric acid levels. Uric Acid 82-91 urate oxidase (pseudogene) Homo sapiens 58-65
27816314-7 2016 Plasma XOR activities of 20 healthy volunteers ranged from 32.8 to 227pmol/h/mL (mean+-SD=89.1+-55.1, n=20), which correlated with alanine transaminase (r=0.827), aspartate transaminase (r=0.487), and uric acid (r=0.502). Uric Acid 201-210 xanthine dehydrogenase Homo sapiens 7-10
27934918-1 2016 Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. Uric Acid 47-56 NLR family, pyrin domain containing 3 Mus musculus 150-155
27922051-5 2016 Using a kinetic assay based on the enzymatic suppression of the spectroscopic interference of the Uox reaction product, we found that the F216S mutant has the same turnover number of the wild-type enzyme but a much-reduced affinity for the urate substrate and xanthine inhibitor. Uric Acid 240-245 urate oxidase Danio rerio 98-101
27922051-6 2016 Our results indicate that the last functioning Uox in hominoid evolution had an increased Michaelis constant, possibly near to upper end of the normal range of urate in the human serum (~300 muM). Uric Acid 160-165 urate oxidase Danio rerio 47-50
27798228-1 2016 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism and converts hypoxanthine to xanthine, and xanthine into uric acid. Uric Acid 136-145 xanthine dehydrogenase Homo sapiens 0-23
27798228-1 2016 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism and converts hypoxanthine to xanthine, and xanthine into uric acid. Uric Acid 136-145 xanthine dehydrogenase Homo sapiens 25-28
27798228-3 2016 XOR inhibitors are primarily used in the treatment of gout, reducing the formation of uric acid and thereby, preventing the formation of monosodium urate crystals. Uric Acid 86-95 xanthine dehydrogenase Homo sapiens 0-3
27798228-3 2016 XOR inhibitors are primarily used in the treatment of gout, reducing the formation of uric acid and thereby, preventing the formation of monosodium urate crystals. Uric Acid 137-153 xanthine dehydrogenase Homo sapiens 0-3
30802390-15 2017 The second one - a gene of uricase "minus" blocked synthesis of allantoin but provided a possibility of re-absorbing uric acid from a pool of primary urine and use it in vivo as an acceptor of active forms of oxygen instead of ascorbic acid under realization of biological function of endoecology,biologic reaction of inflammation. Uric Acid 117-126 urate oxidase (pseudogene) Homo sapiens 27-34
29059654-13 2017 A positive correlation between the serum uric acid concentration of serum insulin (r = 0.27, p <0.001), age (r = 0.21, p <0.002) and BMI patients (r = 0.26, p <0.002) has been shown. Uric Acid 41-50 insulin Homo sapiens 74-81
26779905-7 2016 Cox-proportional hazard model analysis with adjustment for possible confounders including age, renal function, and comorbidities revealed that hyperuricemia (uric acid >=7.0 mg/dL) was an independent risk factor for all-cause and cardiovascular mortality, respectively, in female [hazard ratio (HR) 5.92, 95 % confidence interval (CI) 2.10-14.6 for all-cause mortality, and HR 10.7, 95 % CI 1.76-50.2 for cardiovascular mortality], but not male subjects. Uric Acid 158-167 cytochrome c oxidase subunit 8A Homo sapiens 0-3
27720648-2 2016 Therefore, PDZK1 in renal proximal tubules may affect serum uric acid levels through PDZK1-binding renal urate transporters. Uric Acid 60-69 PDZ domain containing 1 Homo sapiens 85-90
27906618-0 2016 Expression of a human NPT1/SLC17A1 missense variant which increases urate export. Uric Acid 68-73 solute carrier family 17 member 1 Homo sapiens 22-26
27641217-2 2016 The control of serum uric acid level (UA) is important for prevention of TLS. Uric Acid 21-30 FUS RNA binding protein Homo sapiens 73-76
28149983-5 2016 Benefits of SGLT-2 inhibitor use in patients with T2D, in addition to improved glycemic control, include modest weight loss, decreased systolic blood pressure, reduced serum uric acid, and reduced risk of cardiovascular events. Uric Acid 174-183 solute carrier family 5 member 2 Homo sapiens 12-18
27906613-1 2016 Although uricase-knockout (Uox KO) mice are reported to develop uric acid (UA) nephropathy, those that mature without severe nephropathy could be useful for research into purine metabolism in humans. Uric Acid 64-73 urate oxidase Mus musculus 9-16
27906613-1 2016 Although uricase-knockout (Uox KO) mice are reported to develop uric acid (UA) nephropathy, those that mature without severe nephropathy could be useful for research into purine metabolism in humans. Uric Acid 64-73 urate oxidase Mus musculus 27-30
27906636-3 2016 However, the plasma urate levels of URAT1 knockout mice are no different from those of wild-type mice. Uric Acid 20-25 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 36-41
27906618-0 2016 Expression of a human NPT1/SLC17A1 missense variant which increases urate export. Uric Acid 68-73 solute carrier family 17 member 1 Homo sapiens 27-34
27906636-6 2016 The urinary excretion of urate in Urat1-Uox-DKO mice was approximately 25 times higher than those of humans. Uric Acid 25-30 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 34-39
27906613-1 2016 Although uricase-knockout (Uox KO) mice are reported to develop uric acid (UA) nephropathy, those that mature without severe nephropathy could be useful for research into purine metabolism in humans. Uric Acid 75-77 urate oxidase Mus musculus 27-30
27906613-7 2016 UA is thought to act as an anti-oxidizing agent in humans; thus, these results show that Uox KO mice are potential animal models for research into human purine metabolism. Uric Acid 0-2 urate oxidase (pseudogene) Homo sapiens 89-92
27906636-6 2016 The urinary excretion of urate in Urat1-Uox-DKO mice was approximately 25 times higher than those of humans. Uric Acid 25-30 urate oxidase Mus musculus 40-43
27906636-7 2016 With allopurinol, the plasma urate levels of Urat1-Uox-DKO mice were lower than those of Uox-KO mice. Uric Acid 29-34 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 45-50
27906636-7 2016 With allopurinol, the plasma urate levels of Urat1-Uox-DKO mice were lower than those of Uox-KO mice. Uric Acid 29-34 urate oxidase Mus musculus 51-54
27906618-3 2016 Moreover, we demonstrated that human NPT1 is localized to the apical membrane of the renal proximal tubule, and that I269T is the gain-of-function variant which increases the NPT1-mediated urate export. Uric Acid 189-194 solute carrier family 17 member 1 Homo sapiens 175-179
27906618-8 2016 Combined with the previous report that I269T variant did not induce Km changes but increased the Vmax of urate transport in a proteoliposome system, our findings suggest that I269T variant increases NPT1-mediated urate export without increase of NPT1 expression levels on the membrane. Uric Acid 213-218 solute carrier family 17 member 1 Homo sapiens 199-203
27906618-9 2016 Thus, I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. Uric Acid 185-190 solute carrier family 17 member 1 Homo sapiens 42-46
27906618-9 2016 Thus, I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. Uric Acid 185-190 solute carrier family 17 member 1 Homo sapiens 92-96
27906623-4 2016 It has recently been established that the amelioration of gout by dairy products arises from the competition of orotate and urate at the hURAT1 transporter. Uric Acid 124-129 solute carrier family 22 member 12 Homo sapiens 137-143
27906625-2 2016 Recently, we reported that intestinal UA excretion might be enhanced via upregulation of the ATP-binding cassette transporter G2 (Abcg2) in a 5/6 nephrectomy (Nx) rat model. Uric Acid 38-40 ATP binding cassette subfamily G member 2 Rattus norvegicus 93-128
27906625-2 2016 Recently, we reported that intestinal UA excretion might be enhanced via upregulation of the ATP-binding cassette transporter G2 (Abcg2) in a 5/6 nephrectomy (Nx) rat model. Uric Acid 38-40 ATP binding cassette subfamily G member 2 Rattus norvegicus 130-135
27906625-11 2016 These results suggest that the upregulation of Abcg2 mRNA in the ileum triggered by an elevation of serum UA may play a compensatory role in increasing intestinal UA excretion. Uric Acid 106-108 ATP binding cassette subfamily G member 2 Rattus norvegicus 47-52
27906625-11 2016 These results suggest that the upregulation of Abcg2 mRNA in the ileum triggered by an elevation of serum UA may play a compensatory role in increasing intestinal UA excretion. Uric Acid 163-165 ATP binding cassette subfamily G member 2 Rattus norvegicus 47-52
27702489-2 2016 Uricase (urate oxidase) converts uric acid to 5-hydroxyisourate, but it is absent in human and other higher apes. Uric Acid 33-42 urate oxidase (pseudogene) Homo sapiens 0-7
27542954-12 2016 Stimulation of soluble sodium urate induced IL-1beta and Alpk1 mRNA production in mice kidney. Uric Acid 23-35 interleukin 1 beta Mus musculus 44-52
27542954-12 2016 Stimulation of soluble sodium urate induced IL-1beta and Alpk1 mRNA production in mice kidney. Uric Acid 23-35 alpha-kinase 1 Mus musculus 57-62
28164660-7 2016 CONCLUSIONS: High serum uric acid may be independently correlated with the development of tubulointerstitial lesions as well as glomerulosclerosis in HSPN. Uric Acid 24-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 150-154
27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Uric Acid 10-19 xanthine dehydrogenase Mus musculus 121-124
27863506-0 2016 Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout. Uric Acid 22-38 interleukin 37 Homo sapiens 0-14
27264724-8 2016 The serum levels of cathepsin D were inversely correlated with uric acid in preeclamptic patients (r = -0.527; p = 0.03). Uric Acid 63-72 cathepsin D Homo sapiens 20-31
26781472-10 2016 The decline of CEA level was related to uric acid level (p < 0.022). Uric Acid 40-49 CEA cell adhesion molecule 3 Homo sapiens 15-18
27702489-3 2016 Yet, the recombinant form of uricase, Rasburicase, is now commercially available to cure tumor lysis syndrome by lowering serum uric acid level. Uric Acid 128-137 urate oxidase (pseudogene) Homo sapiens 29-36
27607461-1 2016 OBJECTIVE: The enzyme xanthine oxidoreductase (XOR) generates uric acid in the terminal steps of the purine metabolism; meanwhile reactive oxygen species are formed. Uric Acid 62-71 xanthine dehydrogenase Homo sapiens 22-45
27607461-1 2016 OBJECTIVE: The enzyme xanthine oxidoreductase (XOR) generates uric acid in the terminal steps of the purine metabolism; meanwhile reactive oxygen species are formed. Uric Acid 62-71 xanthine dehydrogenase Homo sapiens 47-50
27607461-2 2016 We hypothesized that uric acid production, as assessed indirectly from XOR variants, is associated with hypertension. Uric Acid 21-30 xanthine dehydrogenase Homo sapiens 71-74
27607461-9 2016 CONCLUSION: Pending confirmation, our findings suggest that variation in uric acid production, as captured by genetic variation in XOR, might be a predictor of changes in BP and in the risk of hypertension. Uric Acid 73-82 xanthine dehydrogenase Homo sapiens 131-134
27798180-3 2016 Here, we show that a high-UA diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 26-28 toll-like receptor 4 Rattus norvegicus 102-122
27893692-3 2016 There were positive correlations of serum UA with creatinine (Cr), CRP, and CEA (r = 0.281, P = 0.023; r = 0.312, P = 0.001; r = 0.294, P = 0.017) in rectal cancer patients with metastasis. Uric Acid 42-44 C-reactive protein Homo sapiens 67-70
27893692-3 2016 There were positive correlations of serum UA with creatinine (Cr), CRP, and CEA (r = 0.281, P = 0.023; r = 0.312, P = 0.001; r = 0.294, P = 0.017) in rectal cancer patients with metastasis. Uric Acid 42-44 CEA cell adhesion molecule 3 Homo sapiens 76-79
27796369-6 2016 Moreover, the clinical-trial-tested Pyk2/FAK dual inhibitor PF-562271 reduced monosodium urate-mediated peritonitis, a disease model used for studying the consequences of NLRP3 activation. Uric Acid 78-94 protein tyrosine kinase 2 beta Homo sapiens 36-40
27796369-6 2016 Moreover, the clinical-trial-tested Pyk2/FAK dual inhibitor PF-562271 reduced monosodium urate-mediated peritonitis, a disease model used for studying the consequences of NLRP3 activation. Uric Acid 78-94 protein tyrosine kinase 2 Homo sapiens 41-44
27798180-3 2016 Here, we show that a high-UA diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 26-28 toll-like receptor 4 Rattus norvegicus 124-128
27798180-4 2016 We, subsequently, identify a specific inhibitor of NF-kappaB, BAY11-7085, and show that stereotactic injections of the inhibitor markedly ameliorate UA-induced hippocampal inflammation and memory deficits in C57BL/6 mice. Uric Acid 149-151 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 51-60
27798180-5 2016 We also found that NF-kappaB is activated in the primary cultured hippocampal cells after UA administration. Uric Acid 90-92 nuclear factor kappa B subunit 1 Homo sapiens 19-28
27798180-6 2016 Additionally, C57BL/6 mice that lack TLR4 are substantially protected against UA-induced cognitive dysfunction, possibly due to a decrease in inflammatory gene expression in the hippocampus. Uric Acid 78-80 toll-like receptor 4 Mus musculus 37-41
27798180-8 2016 Together, these results suggest that UA can cause hippocampal inflammation via the TLR4/NF-kappaB pathway, resulting in cognitive dysfunction. Uric Acid 37-39 toll like receptor 4 Homo sapiens 83-87
27798180-8 2016 Together, these results suggest that UA can cause hippocampal inflammation via the TLR4/NF-kappaB pathway, resulting in cognitive dysfunction. Uric Acid 37-39 nuclear factor kappa B subunit 1 Homo sapiens 88-97
27798180-10 2016 SIGNIFICANCE STATEMENT: This work demonstrates that a high-uric acid (UA) diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 59-68 toll-like receptor 4 Rattus norvegicus 147-167
27798180-10 2016 SIGNIFICANCE STATEMENT: This work demonstrates that a high-uric acid (UA) diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 59-68 toll-like receptor 4 Rattus norvegicus 169-173
27798180-10 2016 SIGNIFICANCE STATEMENT: This work demonstrates that a high-uric acid (UA) diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 70-72 toll-like receptor 4 Rattus norvegicus 147-167
27798180-10 2016 SIGNIFICANCE STATEMENT: This work demonstrates that a high-uric acid (UA) diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB pathway, and increases gliosis in the hippocampus of Wistar rats. Uric Acid 70-72 toll-like receptor 4 Rattus norvegicus 169-173
27798180-11 2016 Inhibition of the NF-kappaB signaling pathway markedly ameliorates UA-induced hippocampal inflammation and cognitive dysfunction in C57BL/6 mice. Uric Acid 67-69 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-27
27798180-12 2016 TLR4-knock-out mice are substantially protected against UA-induced cognitive dysfunction, possibly due to a decrease in inflammatory gene expression in the hippocampus. Uric Acid 56-58 toll-like receptor 4 Mus musculus 0-4
27716403-2 2016 Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels. Uric Acid 166-175 solute carrier family 22 member 12 Homo sapiens 103-128
27724862-13 2016 Peroxynitrite also enhanced RhoA, ROCK1, and ROCK2 activity; these actions were partially inhibited by 100 muM urate (peroxynitrite scavenger). Uric Acid 111-116 ras homolog family member A Rattus norvegicus 28-32
27724862-13 2016 Peroxynitrite also enhanced RhoA, ROCK1, and ROCK2 activity; these actions were partially inhibited by 100 muM urate (peroxynitrite scavenger). Uric Acid 111-116 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 34-39
27724862-13 2016 Peroxynitrite also enhanced RhoA, ROCK1, and ROCK2 activity; these actions were partially inhibited by 100 muM urate (peroxynitrite scavenger). Uric Acid 111-116 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 45-50
27713539-1 2016 Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Uric Acid 33-38 solute carrier family 22 member 12 Homo sapiens 115-120
27716403-11 2016 CONCLUSION: The pharmacodynamic effects and in vitro activity of lesinurad are consistent with inhibition of URAT1 and OAT4, major apical transporters for uric acid. Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 109-114
27716403-11 2016 CONCLUSION: The pharmacodynamic effects and in vitro activity of lesinurad are consistent with inhibition of URAT1 and OAT4, major apical transporters for uric acid. Uric Acid 155-164 solute carrier family 22 member 11 Homo sapiens 119-123
27867961-6 2016 As well as having a glucose lowering effect, SGLT-2 inhibitors also reduce blood pressure, promote weight loss and reduce uric acid levels. Uric Acid 122-131 solute carrier family 5 member 2 Homo sapiens 45-51
27414413-6 2016 Several compounds have superior inhibitory activity of URAT1 with the availability of urate-lowering treatment. Uric Acid 86-91 solute carrier family 22 member 12 Homo sapiens 55-60
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 1 Homo sapiens 388-416
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 1 Homo sapiens 418-422
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 2 member 9 Homo sapiens 241-262
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 2 member 9 Homo sapiens 264-269
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 12 Homo sapiens 278-297
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 12 Homo sapiens 299-304
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 338-343
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 6 Homo sapiens 345-374
27522260-3 2016 The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). Uric Acid 40-49 solute carrier family 22 member 6 Homo sapiens 376-382
27271513-1 2016 The aim of this study was to clarify the role of p62-dependent mitochondrial apoptosis in the initiation of monosodium urate (MSU) crystal-induced inflammation in macrophages. Uric Acid 108-124 nucleoporin 62 Mus musculus 49-52
27412397-0 2016 Erratum to: Enhanced p62 is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage. Uric Acid 141-157 nucleoporin 62 Mus musculus 21-24
27412397-0 2016 Erratum to: Enhanced p62 is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage. Uric Acid 141-157 interleukin 1 beta Mus musculus 90-107
27271513-1 2016 The aim of this study was to clarify the role of p62-dependent mitochondrial apoptosis in the initiation of monosodium urate (MSU) crystal-induced inflammation in macrophages. Uric Acid 126-129 nucleoporin 62 Mus musculus 49-52
27271513-0 2016 Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage. Uric Acid 129-145 nucleoporin 62 Mus musculus 9-12
27271513-0 2016 Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage. Uric Acid 129-145 interleukin 1 beta Mus musculus 78-95
27271513-5 2016 Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase. Uric Acid 34-37 BCL2-associated X protein Mus musculus 69-72
27271513-5 2016 Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase. Uric Acid 34-37 caspase 3 Mus musculus 74-83
27271513-5 2016 Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase. Uric Acid 34-37 caspase 9 Mus musculus 85-94
27271513-5 2016 Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase. Uric Acid 34-37 poly (ADP-ribose) polymerase family, member 1 Mus musculus 100-105
27271513-5 2016 Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase. Uric Acid 34-37 interleukin 1 beta Mus musculus 151-159
27621185-0 2016 Associations of fibroblast growth factor 23 with urate metabolism in patients with chronic kidney disease. Uric Acid 49-54 fibroblast growth factor 23 Homo sapiens 16-43
28163535-6 2016 URAT1 is responsible for the majority of uric acid absorption from kidneys to the circulation. Uric Acid 41-50 solute carrier family 22 member 12 Homo sapiens 0-5
27621185-1 2016 OBJECTIVE: In patients with preserved kidney function, a positive association of fibroblast growth factor 23 (FGF23) with serum uric acid (SUA) has been reported; however, the relationship in overall chronic kidney disease (CKD) patients has not been investigated. Uric Acid 128-137 fibroblast growth factor 23 Homo sapiens 81-108
27621185-11 2016 CONCLUSIONS: FGF23 was independently associated with urate metabolism in this population of CKD patients. Uric Acid 53-58 fibroblast growth factor 23 Homo sapiens 13-18
27621185-1 2016 OBJECTIVE: In patients with preserved kidney function, a positive association of fibroblast growth factor 23 (FGF23) with serum uric acid (SUA) has been reported; however, the relationship in overall chronic kidney disease (CKD) patients has not been investigated. Uric Acid 128-137 fibroblast growth factor 23 Homo sapiens 110-115
27621185-12 2016 FGF23 might also have a stronger association with urate metabolism in males compared with females. Uric Acid 50-55 fibroblast growth factor 23 Homo sapiens 0-5
27621185-2 2016 No report has examined the relationship between FGF23 and uric acid clearance (CUA). Uric Acid 58-67 fibroblast growth factor 23 Homo sapiens 48-53
27621185-3 2016 The aim of the present study was to determine whether FGF23 is independently associated with urate metabolism in patients with CKD stages 1-5. Uric Acid 93-98 fibroblast growth factor 23 Homo sapiens 54-59
27494876-5 2016 As a rate-limiting enzyme in the purine catabolic pathway, XOR generates two end-products, uric acid and reactive oxygen species (ROS). Uric Acid 91-100 xanthine dehydrogenase Mus musculus 59-62
27939490-3 2016 In the present study we assess whether adenosine deaminase (ADA) activity is altered in women with preeclampsia (PE) and contributes to elevated levels of uric acid and pro-inflammatory cytokine production. Uric Acid 155-164 adenosine deaminase Homo sapiens 39-58
27939490-3 2016 In the present study we assess whether adenosine deaminase (ADA) activity is altered in women with preeclampsia (PE) and contributes to elevated levels of uric acid and pro-inflammatory cytokine production. Uric Acid 155-164 adenosine deaminase Homo sapiens 60-63
27939490-9 2016 A positive correlation between ADA and uric acid levels was identified in women with PE (P<0.001). Uric Acid 39-48 adenosine deaminase Homo sapiens 31-34
27939490-11 2016 CONCLUSION: An elevation in ADA activity in women with PE may contribute to their increased levels of uric acid and pro-inflammatory immune activity. Uric Acid 102-111 adenosine deaminase Homo sapiens 28-31
27206713-0 2016 Synovial fluid proteins are required for the induction of interleukin-1beta production by monosodium urate crystals. Uric Acid 90-106 interleukin 1 beta Homo sapiens 58-75
27206713-1 2016 OBJECTIVES: Monosodium urate (MSU) crystal deposition in gouty joints promotes the release of inflammatory mediators, in particular interleukin (IL)-1beta. Uric Acid 12-28 interleukin 1 beta Homo sapiens 132-154
27206713-8 2016 RESULTS: Exposure of monocytes/macrophages to MSU crystals alone induced the moderate release of IL-8 but not of IL-1beta. Uric Acid 46-49 C-X-C motif chemokine ligand 8 Homo sapiens 97-101
27384400-9 2016 Among patients in the secondary prevention subgroup, those with positive anti-apoA-1 IgG levels had lower HDL (p=0.002) and magnesium (p=0.001) levels, but increased uric acid and high-sensitivity C-reactive protein levels (p=0.022, and p<0.001, respectively) compared to patients with negative anti-apoA-1 IgG levels. Uric Acid 166-175 apolipoprotein A1 Homo sapiens 78-84
27234527-1 2016 Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and IL-1beta secretion. Uric Acid 29-45 interleukin 1 beta Mus musculus 168-176
27234527-1 2016 Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and IL-1beta secretion. Uric Acid 47-50 interleukin 1 beta Mus musculus 168-176
26493023-5 2016 RESULTS: Uric acid was associated with several cardiovascular risk factors, namely higher HOMA-IR, CRP, TG, BMI, waist, SBP, preperitoneal fat and cIMT (all P < 0.001 to P < 0.0001). Uric Acid 9-18 C-reactive protein Homo sapiens 99-102
26493023-5 2016 RESULTS: Uric acid was associated with several cardiovascular risk factors, namely higher HOMA-IR, CRP, TG, BMI, waist, SBP, preperitoneal fat and cIMT (all P < 0.001 to P < 0.0001). Uric Acid 9-18 CIMT Homo sapiens 147-151
26493023-6 2016 Significant BMI and preperitoneal fat interactions were documented in the relationship between uric acid and cIMT (both P < 0.05), as uric acid was preferentially related to cIMT in heavier children (beta = 0.247, P < 0.001, r(2) = 9.1%) and in children with more preperitoneal fat (beta = 0.263, P < 0.0001, r(2) = 11.9%). Uric Acid 95-104 CIMT Homo sapiens 109-113
26493023-7 2016 CONCLUSIONS: Serum uric acid is associated with cIMT in asymptomatic prepubertal children. Uric Acid 19-28 CIMT Homo sapiens 48-52
27217070-1 2016 OBJECTIVES: HLA-B*5801 allele carriage (a strong determinant of allopurinol hypersensitivity syndrome) varies substantially among races, which may lead to racial disparities in the risk of Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) in the context of urate-lowering drug adverse events (ULDAEs). Uric Acid 275-280 major histocompatibility complex, class I, B Homo sapiens 12-17
27667270-11 2016 Higher plasma aldosterone concentration and lower plasma renin activity were associated with lower UA level in PA group. Uric Acid 99-101 renin Homo sapiens 57-62
27667270-13 2016 The reduced UA level in PA patients is possibly due to the high plasma aldosterone concentration and low plasma renin activity. Uric Acid 12-14 renin Homo sapiens 112-117
27288985-2 2016 Transporters for urate are located in the proximal tubule where uric acid is secreted and extensively reabsorbed: secretion is principally ensured by the highly variable ABCG2 gene. Uric Acid 17-22 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 170-175
27285673-5 2016 The aim of this study was to investigate whether the expression of HMGB1differed between early onset and late onset preeclampsia or severe and mild preeclampsia and whether its expression correlated with the levels of uric acid. Uric Acid 218-227 high mobility group box 1 Homo sapiens 67-72
27662452-6 2016 CysC level correlated significantly with age (r=0.494, P<0.001), sex (r=0.150, P=0.011), and serum creatinine level (r=0.377, P<0.001), but not with levels of urea or uric acid (P>0.05). Uric Acid 167-176 cystatin C Homo sapiens 0-4
27285673-8 2016 The expression of HMGB1 in preeclamptic placentae or in first trimester and term placentae that had been treated with uric acid was measured. Uric Acid 118-127 high mobility group box 1 Homo sapiens 18-23
27285673-10 2016 The circulating levels of uric acid were significantly increased in preeclampsia and correlated with the expression of HMGB1. Uric Acid 26-35 high mobility group box 1 Homo sapiens 119-124
27352852-0 2016 Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. Uric Acid 82-87 solute carrier family 22 member 12 Homo sapiens 15-20
27795632-1 2016 Familial juvenile hyperuricemic nephropathy (FJHN), characterized by early-onset hyperuricemia, reduced fractional excretion of uric acid, and chronic renal failure is caused due to mutation in uromodulin (UMOD) gene. Uric Acid 128-137 uromodulin Homo sapiens 194-204
27465529-0 2016 Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. Uric Acid 102-111 urate oxidase Mus musculus 0-7
27465529-3 2016 We found that uric acid was increased in the airways of mice exposed to NO2 and that administration of uricase inhibited the development of OVA-driven allergic airway disease subsequent to OVA challenge, as well as the generation of OVA-specific Abs. Uric Acid 14-23 urate oxidase Mus musculus 103-110
26571141-7 2016 CONCLUSIONS: Serum ceruloplasmin level may have significant role as the markers of oxidative stress in pre-eclampsia especially when used in combination with uric acid levels. Uric Acid 158-167 ceruloplasmin Homo sapiens 19-32
27352852-0 2016 Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. Uric Acid 82-87 urate oxidase (pseudogene) Homo sapiens 25-32
27352852-3 2016 Uric acid is primarily excreted through the kidneys with 90% reabsorbed back into the bloodstream through the uric acid transporter URAT1. Uric Acid 0-9 solute carrier family 22 member 12 Homo sapiens 132-137
27352852-5 2016 We discovered that URAT1 proteins from humans and baboons have higher affinity for uric acid compared with transporters from rats and mice. Uric Acid 83-92 solute carrier family 22 member 12 Homo sapiens 19-24
27352852-7 2016 Ancestral URAT1 sequences were computationally inferred and ancient transporters were resurrected and assayed, revealing that affinity for uric acid was increased during the evolution of primates. Uric Acid 139-148 solute carrier family 22 member 12 Homo sapiens 10-15
27571712-2 2016 ABCG2 dysfunction markedly increased serum uric acid (SUA) levels in 106 hemodialysis patients (P = 1.1 x 10(-4)), which demonstrated the physiological role of ABCG2 for intestinal urate excretion because their urate excretion almost depends on intestinal excretion via ABCG2. Uric Acid 43-52 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
27571712-2 2016 ABCG2 dysfunction markedly increased serum uric acid (SUA) levels in 106 hemodialysis patients (P = 1.1 x 10(-4)), which demonstrated the physiological role of ABCG2 for intestinal urate excretion because their urate excretion almost depends on intestinal excretion via ABCG2. Uric Acid 43-52 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 160-165
27272206-6 2016 The limits of detection (LODs) found for glucose and UA assays were 23 and 37 muM, respectively. Uric Acid 53-55 latexin Homo sapiens 78-81
27563918-0 2016 Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population. Uric Acid 26-35 glutamic--pyruvic transaminase Homo sapiens 49-73
27560997-13 2016 CONCLUSIONS: This study revealed that an elevated uric acid level was an independent risk factor for ESKD in female IgAN patients. Uric Acid 50-59 IGAN1 Homo sapiens 116-120
27560997-14 2016 Therefore, uric acid might be a treatable target in female IgAN patients. Uric Acid 11-20 IGAN1 Homo sapiens 59-63
27423335-2 2016 Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS). Uric Acid 95-104 xanthine dehydrogenase Homo sapiens 0-23
27094945-1 2016 The objective of these clinical studies was to assess the safety and urate lowering activity of a novel urate transporter 1 (URAT1)/ xanthine oxidase (XO) inhibitor PF-06743649 in healthy subjects and gout patients. Uric Acid 69-74 solute carrier family 22 member 12 Homo sapiens 104-123
26947600-2 2016 Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. Uric Acid 16-25 insulin Homo sapiens 138-145
26500098-8 2016 However, urate uptake of GLUT9 variants prepared for both isoforms were not significantly different. Uric Acid 9-14 solute carrier family 2 member 9 Homo sapiens 25-30
26500098-10 2016 Our finding of defects in the SLC2A9 and SLC22A12 genes show the following: renal hypouricemia is not restricted to East Asia populations; urate uptake of GLUT9 variants prepared for both isoforms were not significantly different; renal hypouricemia type 2 has more wide clinical variability than type 1; the phenotypic severity of renal hypouricemia is not correlated with results of functional characterizations of URAT1 and GLUT9 variants. Uric Acid 139-144 solute carrier family 2 member 9 Homo sapiens 30-36
26500098-10 2016 Our finding of defects in the SLC2A9 and SLC22A12 genes show the following: renal hypouricemia is not restricted to East Asia populations; urate uptake of GLUT9 variants prepared for both isoforms were not significantly different; renal hypouricemia type 2 has more wide clinical variability than type 1; the phenotypic severity of renal hypouricemia is not correlated with results of functional characterizations of URAT1 and GLUT9 variants. Uric Acid 139-144 solute carrier family 22 member 12 Homo sapiens 41-49
26500098-10 2016 Our finding of defects in the SLC2A9 and SLC22A12 genes show the following: renal hypouricemia is not restricted to East Asia populations; urate uptake of GLUT9 variants prepared for both isoforms were not significantly different; renal hypouricemia type 2 has more wide clinical variability than type 1; the phenotypic severity of renal hypouricemia is not correlated with results of functional characterizations of URAT1 and GLUT9 variants. Uric Acid 139-144 solute carrier family 2 member 9 Homo sapiens 155-160
27022940-5 2016 SIRT1 suppressed the increased serum uric acid level but up-regulated the expression of urate transporter ATP-binding cassette subfamily G member 2 (ABCG2) in the ileum of hyperuricemic mice. Uric Acid 37-46 sirtuin 1 Mus musculus 0-5
26887821-7 2016 (3) The inhibition of xanthine oxidoreductase leading to modulation of intracellular superoxide and plasma uric acid, a risk factor for developing type 2 diabetes. Uric Acid 107-116 xanthine dehydrogenase Homo sapiens 22-45
27423335-2 2016 Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS). Uric Acid 95-104 xanthine dehydrogenase Homo sapiens 25-28
27423335-5 2016 Accordingly, urate-lowering drugs such as allopurinol, an XOR-inhibitor, are extensively used for the treatment of gout. Uric Acid 13-18 xanthine dehydrogenase Homo sapiens 58-61
26835700-9 2016 These findings provide further evidence for a significant contribution of ABCG2 to extra-renal (gut) clearance of urate. Uric Acid 114-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 74-79
27486328-11 2016 Significant changes in the uric acid level were found for SGLT2 inhibitors versus placebo therapy (P=0.005) or active control (P<0.001). Uric Acid 27-36 solute carrier family 5 member 2 Homo sapiens 58-63
23884077-8 2016 Furthermore, ketotifen significantly decreased proinflammatory mediators, including nitric oxide, interleukin-1beta, and interleukin-6, production in MSU-treated rats. Uric Acid 150-153 interleukin 1 beta Rattus norvegicus 98-115
23884077-8 2016 Furthermore, ketotifen significantly decreased proinflammatory mediators, including nitric oxide, interleukin-1beta, and interleukin-6, production in MSU-treated rats. Uric Acid 150-153 interleukin 6 Rattus norvegicus 121-134
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 hypoxanthine guanine phosphoribosyl transferase Mus musculus 92-131
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 hypoxanthine guanine phosphoribosyl transferase Mus musculus 133-137
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 hypoxanthine guanine phosphoribosyl transferase Mus musculus 242-246
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 urate oxidase Mus musculus 298-311
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 urate oxidase Mus musculus 318-321
27170514-3 2016 We clarified the mechanism of the false in vitro UA elevation using mice with highly active hypoxanthine phosphoribosyl transferase (Hprt) of B6-ChrXC(MSM), a consomic mouse strain with the chromosome portion of Mus musculus morocinus in the Hprt gene site, or mice with a targeted deletion of the urate oxidase gene (Uox) (Uox-knockout (KO)). Uric Acid 49-51 urate oxidase Mus musculus 324-327
27170514-5 2016 The uric acid level of Uox-KO mice was approximately 10 times higher than that of control, did not elevated after incubation in the test tube. Uric Acid 4-13 urate oxidase Mus musculus 23-26
27170514-9 2016 In conclusion, "false in vitro elevation of uric acid level" seems to be caused by low levels of erythrocyte HPRT activity and the low plasma uric acid level of laboratory mice. Uric Acid 44-53 hypoxanthine guanine phosphoribosyl transferase Mus musculus 109-113
27289126-1 2016 The striking and unexpected relative risk reductions in cardiovascular (CV) mortality (38%), hospitalization for heart failure (35%), and death from any cause (32%) observed in the EMPA-REG OUTCOME trial using an inhibitor of sodium-glucose cotransporter 2 (SGLT2) in patients with type 2 diabetes and high CV risk have raised the possibility that mechanisms other than those observed in the trial-modest improvement in glycemic control, small decrease in body weight, and persistent reductions in blood pressure and uric acid level-may be at play. Uric Acid 517-526 solute carrier family 5 member 2 Homo sapiens 226-256
27540517-6 2016 Recently in the field of cancer and ageing, scientists claimed that uric acid can be used to regulate reactive oxygen species (ROS), leading to cancer and ageing prevention; these findings highlight the role of miRNA-based inhibition of the SLC2A9 antioxidant pathway in cancer, as a novel way to kill malignant cells, while a patient is fighting with cancer. Uric Acid 68-77 solute carrier family 2 member 9 Homo sapiens 241-247
27185581-4 2016 Due to the inappropriate high levels of uric acid compared to kidney function, screening of hypoxanthine-guanine phosphoribosyltransferase (HPRT) related diseases was initiated. Uric Acid 40-49 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 92-138
27158916-4 2016 In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown. Uric Acid 134-143 urate oxidase Mus musculus 164-177
27158916-4 2016 In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown. Uric Acid 215-224 urate oxidase Mus musculus 164-177
25535039-7 2016 However, significant low uric acid level (p < 0.05) was noted in MT2 plus vit E-treated rats compared with MT2-treated group. Uric Acid 25-34 metallothionein 2A Rattus norvegicus 68-71
27185581-4 2016 Due to the inappropriate high levels of uric acid compared to kidney function, screening of hypoxanthine-guanine phosphoribosyltransferase (HPRT) related diseases was initiated. Uric Acid 40-49 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 140-144
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 NPR3 like, GATOR1 complex subunit Homo sapiens 144-149
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 caspase 1 Homo sapiens 180-189
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 interleukin 1 beta Homo sapiens 223-231
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 interleukin 18 Homo sapiens 236-241
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 NPR3 like, GATOR1 complex subunit Homo sapiens 144-149
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 caspase 1 Homo sapiens 180-189
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 interleukin 1 beta Homo sapiens 223-231
27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 interleukin 18 Homo sapiens 236-241
26511169-0 2016 Maternal serum uric acid concentration is associated with the expression of tumour necrosis factor-alpha and intercellular adhesion molecule-1 in patients with preeclampsia. Uric Acid 15-24 intercellular adhesion molecule 1 Homo sapiens 109-142
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 42-51 solute carrier family 2 member 9 Homo sapiens 71-77
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 42-51 solute carrier family 2 member 9 Homo sapiens 90-96
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 42-51 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-113
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 181-190 solute carrier family 2 member 9 Homo sapiens 71-77
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 181-190 solute carrier family 2 member 9 Homo sapiens 90-96
26993665-9 2016 CONCLUSIONS: Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes. Uric Acid 181-190 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-113
27420973-9 2016 Cells treated with 30 mg/dL UA for 96 h showed the highest ATP levels, while SDH and CCO activities at 48, 72, and 96 h post-UA treatment were significantly lower than those at 24 h (P < 0.01). Uric Acid 28-30 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 77-80
27420973-10 2016 Moreover, cells treated with 30 mg/dL UA showed a 0.02 +- 0.02 and 0.15 +- 0.01 mmol/ mg/min decrease in SDH and CCO levels after 72 h. Therefore, we concluded that high concentrations of UA may induce oxidative stress in hepatocyte mitochondria, increasing ROS production and ultimately resulting in mitochondrial damage. Uric Acid 38-40 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 105-108
27420973-10 2016 Moreover, cells treated with 30 mg/dL UA showed a 0.02 +- 0.02 and 0.15 +- 0.01 mmol/ mg/min decrease in SDH and CCO levels after 72 h. Therefore, we concluded that high concentrations of UA may induce oxidative stress in hepatocyte mitochondria, increasing ROS production and ultimately resulting in mitochondrial damage. Uric Acid 188-190 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 105-108
26316329-6 2016 All other mammals possess the enzyme uricase that converts uric acid to allantoin that is easily eliminated through urine. Uric Acid 59-68 urate oxidase (pseudogene) Homo sapiens 37-44
26320372-4 2016 Recently, evidence has been accumulated suggesting that chronic urate deposition requires a correct treatment not limited to acute episodes based on the modulation of the activity of key enzymes involved in metabolism and excretion of urate including xanthine oxidoreductase (XO) and URAT1. Uric Acid 64-69 xanthine dehydrogenase Homo sapiens 251-274
26320372-4 2016 Recently, evidence has been accumulated suggesting that chronic urate deposition requires a correct treatment not limited to acute episodes based on the modulation of the activity of key enzymes involved in metabolism and excretion of urate including xanthine oxidoreductase (XO) and URAT1. Uric Acid 64-69 xanthine dehydrogenase Homo sapiens 276-278
26320372-4 2016 Recently, evidence has been accumulated suggesting that chronic urate deposition requires a correct treatment not limited to acute episodes based on the modulation of the activity of key enzymes involved in metabolism and excretion of urate including xanthine oxidoreductase (XO) and URAT1. Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 284-289
26320372-5 2016 The present review article will try to summarize the most recent evidences on the efficacy of XO inhibitors and uricosuric compounds in lowering uric acid levels in both the bloodstream and peripheral tissues. Uric Acid 145-154 xanthine dehydrogenase Homo sapiens 94-96
26320372-6 2016 In particular, we will focus on the effect of novel XO inhibitors in counteracting uric acid overproduction. Uric Acid 83-92 xanthine dehydrogenase Homo sapiens 52-54
26320372-7 2016 On the other hand, the effect of lowering uric acid levels via XO inhibition will be correlated with attenuation oxidative stress which leads to endothelial dysfunction thereby contributing to the pathophysiology of diabetes, hypertension, arteriosclerosis, and chronic heart failure. Uric Acid 42-51 xanthine dehydrogenase Homo sapiens 63-65
26320372-8 2016 Hence, scavenging and prevention of the XO generated oxygen radical accumulation emerge as an intriguing novel treatment option to counteract uric acid-induced tissue damages. Uric Acid 142-151 xanthine dehydrogenase Homo sapiens 40-42
27375492-6 2016 Plasma hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity in dolphins suggests an elevated purine recycling rate, and a mechanism for avoiding accumulation of non-recyclable purines (xanthine and uric acid). Uric Acid 210-219 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 7-54
27375492-6 2016 Plasma hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity in dolphins suggests an elevated purine recycling rate, and a mechanism for avoiding accumulation of non-recyclable purines (xanthine and uric acid). Uric Acid 210-219 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 56-61
27278520-9 2016 The number of CD4(+)CD25(+) cells was negatively related to blood urea nitrogen, serum uric acid, proteinuria, and supernatant IL-4; whereas positively associated with estimated glomerular filtration rate in patients. Uric Acid 87-96 CD4 molecule Homo sapiens 14-17
27041280-3 2016 Xanthine dehydrogenase (XDH) that requires a molybdenum cofactor (MoCo) for its activity is a key enzyme for uric acid synthesis. Uric Acid 109-118 xanthine dehydrogenase 1 Bombyx mori 0-22
27274832-0 2016 Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Uric Acid 50-59 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 12-17
27274832-3 2016 Nat Rev Drug Discov 2015; 14: 29-44) suggests that multispecific solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters in different tissues are part of an inter-organ communication system that maintains levels of urate and other metabolites after organ injury. Uric Acid 229-234 C-C motif chemokine ligand 21 Homo sapiens 81-84
27274832-11 2016 CONCLUSIONS: In patients of EA with CKD (CRIC cohort), we found striking associations between uric acid and SNPs on ABCG2, a key transporter of uric acid by intestine. Uric Acid 94-103 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 116-121
27274832-11 2016 CONCLUSIONS: In patients of EA with CKD (CRIC cohort), we found striking associations between uric acid and SNPs on ABCG2, a key transporter of uric acid by intestine. Uric Acid 144-153 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 116-121
27274832-13 2016 SNPs in other SLC (e.g. SLC22A8 or OAT3) and ABC (e.g. ABCC4 or MRP4) genes appear to make a weak gender-dependent contribution to uric acid homeostasis in CKD. Uric Acid 131-140 C-C motif chemokine ligand 21 Homo sapiens 14-17
27274832-13 2016 SNPs in other SLC (e.g. SLC22A8 or OAT3) and ABC (e.g. ABCC4 or MRP4) genes appear to make a weak gender-dependent contribution to uric acid homeostasis in CKD. Uric Acid 131-140 solute carrier family 22 member 8 Homo sapiens 24-31
27274832-13 2016 SNPs in other SLC (e.g. SLC22A8 or OAT3) and ABC (e.g. ABCC4 or MRP4) genes appear to make a weak gender-dependent contribution to uric acid homeostasis in CKD. Uric Acid 131-140 solute carrier family 22 member 8 Homo sapiens 35-39
27274832-13 2016 SNPs in other SLC (e.g. SLC22A8 or OAT3) and ABC (e.g. ABCC4 or MRP4) genes appear to make a weak gender-dependent contribution to uric acid homeostasis in CKD. Uric Acid 131-140 ATP binding cassette subfamily C member 4 Homo sapiens 55-60
27274832-13 2016 SNPs in other SLC (e.g. SLC22A8 or OAT3) and ABC (e.g. ABCC4 or MRP4) genes appear to make a weak gender-dependent contribution to uric acid homeostasis in CKD. Uric Acid 131-140 ATP binding cassette subfamily C member 4 Homo sapiens 64-68
27274832-14 2016 As renal urate transport is affected in the setting of declining kidney function, extra-renal ABCG2 appears to play a compensatory role-a notion consistent with animal studies and the Remote Sensing and Signaling Hypothesis. Uric Acid 9-14 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 94-99
27274832-16 2016 Therapies focused on enhancing ABCG2 urate handling may be helpful in the setting of CKD and hyperuricemia. Uric Acid 37-42 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 31-36
27273589-0 2016 Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia. Uric Acid 41-46 uncoupling protein 2 Homo sapiens 7-11
27273589-2 2016 This study aimed to investigate the association between UCP2 variants and serum urate as well as hyperuricemia in a Chinese population. Uric Acid 80-85 uncoupling protein 2 Homo sapiens 56-60
27273589-9 2016 This present study identified a novel gene, UCP2, that influences the serum urate concentration and the risk of hyperuricemia, and the degree of association varies with gender and BMI levels. Uric Acid 76-81 uncoupling protein 2 Homo sapiens 44-48
27041280-3 2016 Xanthine dehydrogenase (XDH) that requires a molybdenum cofactor (MoCo) for its activity is a key enzyme for uric acid synthesis. Uric Acid 109-118 xanthine dehydrogenase 1 Bombyx mori 24-27
27006202-2 2016 In this assay, the amount of [(13) C2 ,(15) N2 ]uric acid (UA) produced by XOR was determined by using LC/TQMS. Uric Acid 59-61 xanthine dehydrogenase Homo sapiens 75-78
26868525-1 2016 This study evaluated the role of macrophage migration inhibitory factor in inflammation caused by monosodium urate crystals. Uric Acid 98-114 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 33-71
26868525-3 2016 In mice, the injection of monosodium urate crystals into the knee joint increased the levels of macrophage migration inhibitory factor in macrophages and in inflamed tissue. Uric Acid 26-42 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 96-134
26868525-5 2016 Importantly, the accumulation of neutrophils and the amount IL-1beta in the joints were reduced in macrophage migration inhibitory factor-deficient mice when injected with monosodium urate crystals. Uric Acid 172-188 interleukin 1 beta Mus musculus 60-68
26868525-5 2016 Importantly, the accumulation of neutrophils and the amount IL-1beta in the joints were reduced in macrophage migration inhibitory factor-deficient mice when injected with monosodium urate crystals. Uric Acid 172-188 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 99-137
26872603-0 2016 Monosodium Urate Crystals Induce Functional Expression of P2Y14 Receptor in Human Keratinocytes. Uric Acid 0-16 purinergic receptor P2Y14 Homo sapiens 58-72
27021217-6 2016 Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Uric Acid 90-99 xanthine dehydrogenase Mus musculus 134-150
25829326-3 2016 Urate-induced inflammasome pathway is comprised of urate crystal uptake into intracellular lysosomes and subsequent lysosomal rupture with mitochondrial reactive oxygen species (ROS) production, which activates the NLRP3 inflammasome. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 215-220
25829326-3 2016 Urate-induced inflammasome pathway is comprised of urate crystal uptake into intracellular lysosomes and subsequent lysosomal rupture with mitochondrial reactive oxygen species (ROS) production, which activates the NLRP3 inflammasome. Uric Acid 51-56 NLR family pyrin domain containing 3 Homo sapiens 215-220
26727147-1 2016 INTRODUCTION: Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated. Uric Acid 20-29 insulin Homo sapiens 94-101
26542604-0 2016 Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men. Uric Acid 136-145 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 0-24
26542604-0 2016 Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men. Uric Acid 136-145 aldehyde dehydrogenase 2 family member Homo sapiens 41-65
26542604-7 2016 The ADH1B*2 plus ALDH2*1/*1 combination yielded the highest ORs (2.86 [1.61-5.10] and 6.21 [1.49-25.88] for a UA level of >416 mumol/l and >=535 mumol/l, respectively), compared with the ADH1B*1/*1 plus ALDH2*1/*2 combination. Uric Acid 110-112 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 4-9
26542604-7 2016 The ADH1B*2 plus ALDH2*1/*1 combination yielded the highest ORs (2.86 [1.61-5.10] and 6.21 [1.49-25.88] for a UA level of >416 mumol/l and >=535 mumol/l, respectively), compared with the ADH1B*1/*1 plus ALDH2*1/*2 combination. Uric Acid 110-112 aldehyde dehydrogenase 2 family member Homo sapiens 17-22
26542604-7 2016 The ADH1B*2 plus ALDH2*1/*1 combination yielded the highest ORs (2.86 [1.61-5.10] and 6.21 [1.49-25.88] for a UA level of >416 mumol/l and >=535 mumol/l, respectively), compared with the ADH1B*1/*1 plus ALDH2*1/*2 combination. Uric Acid 110-112 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 193-198
26542604-7 2016 The ADH1B*2 plus ALDH2*1/*1 combination yielded the highest ORs (2.86 [1.61-5.10] and 6.21 [1.49-25.88] for a UA level of >416 mumol/l and >=535 mumol/l, respectively), compared with the ADH1B*1/*1 plus ALDH2*1/*2 combination. Uric Acid 110-112 aldehyde dehydrogenase 2 family member Homo sapiens 209-214
26542604-9 2016 CONCLUSIONS: The faster metabolism of ethanol and acetaldehyde by the ADH1B*2 allele and ALDH2*1/*1 genotype and higher ketosis levels were associated with higher UA levels in alcoholics, while diabetes and the consumption of sake were negative determinants. Uric Acid 163-165 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 70-75
26542604-9 2016 CONCLUSIONS: The faster metabolism of ethanol and acetaldehyde by the ADH1B*2 allele and ALDH2*1/*1 genotype and higher ketosis levels were associated with higher UA levels in alcoholics, while diabetes and the consumption of sake were negative determinants. Uric Acid 163-165 aldehyde dehydrogenase 2 family member Homo sapiens 89-94
27169898-2 2016 Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Uric Acid 55-58 alpha kinase 1 Homo sapiens 0-14
27169898-2 2016 Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Uric Acid 55-58 alpha kinase 1 Homo sapiens 16-21
26727147-0 2016 Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. Uric Acid 44-53 insulin Homo sapiens 88-95
26917248-7 2016 Model 2 with CSF tau showed that higher levels of uric acid alleviated the detrimental effect of tau on cognitive decline in female subjects but not in male subjects. Uric Acid 50-59 microtubule associated protein tau Homo sapiens 17-20
26917248-7 2016 Model 2 with CSF tau showed that higher levels of uric acid alleviated the detrimental effect of tau on cognitive decline in female subjects but not in male subjects. Uric Acid 50-59 microtubule associated protein tau Homo sapiens 97-100
27007871-1 2016 To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary purines, we previously identified adenosine derivative 1 as a potent hCNT2 inhibitor (IC50 = 0.64 muM), but further study was hampered due to its poor solubility. Uric Acid 123-128 solute carrier family 28 member 2 Homo sapiens 48-86
26509876-7 2016 PM10-induced uric acid mediates allergic sensitization and augments antigen-specific T-cell proliferation, which is inhibited by uricase. Uric Acid 13-22 urate oxidase (pseudogene) Homo sapiens 129-136
27052425-7 2016 Of note, inhibition of Nox4 with DPI prevented uric acid-induced cell injury by suppressing ROS generation and P38/ERK activation. Uric Acid 47-56 mitogen-activated protein kinase 1 Homo sapiens 111-114
27052425-7 2016 Of note, inhibition of Nox4 with DPI prevented uric acid-induced cell injury by suppressing ROS generation and P38/ERK activation. Uric Acid 47-56 mitogen-activated protein kinase 1 Homo sapiens 115-118
27152019-6 2016 By contrast, in leaf mesophyll cells, XDH1 carries out xanthine dehydrogenase activity to produce uric acid in local and systemic tissues to scavenge H2O2 from stressed chloroplasts, thereby protecting plants from stress-induced oxidative damage. Uric Acid 98-107 xanthine dehydrogenase 1 Arabidopsis thaliana 38-42
27143182-0 2016 [The correlation between serum uric acid level and early-phase insulin secretion in subjects with normal glucose regulation]. Uric Acid 31-40 insulin Homo sapiens 63-70
27143182-1 2016 OBJECTIVE: To investigate the correlation between serum uric acid (SUA) level and early-phase insulin secretion in subjects with normal glucose regulation (NGR). Uric Acid 56-65 insulin Homo sapiens 94-101
27007871-1 2016 To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary purines, we previously identified adenosine derivative 1 as a potent hCNT2 inhibitor (IC50 = 0.64 muM), but further study was hampered due to its poor solubility. Uric Acid 123-128 solute carrier family 28 member 2 Homo sapiens 88-93
27924211-0 2016 Circulating miR-126 and miR-499 reflect progression of cardiovascular disease; correlations with uric acid and ejection fraction. Uric Acid 97-106 microRNA 126 Homo sapiens 12-19
27924211-6 2016 Interestingly, a strong correlation was observed between both miRNAs and uric acid (UA) levels with ventricular contractility measured as ejection fraction (EF) (miR-499/EF%, r = 0.58, p~0.004; UA/EF%, r = -0.6, p~0.006; UA/miR-499, r = -0.34; UA/miR-126, r = 0.5, p~0.01). Uric Acid 84-86 microRNA 499a Homo sapiens 224-231
27924211-6 2016 Interestingly, a strong correlation was observed between both miRNAs and uric acid (UA) levels with ventricular contractility measured as ejection fraction (EF) (miR-499/EF%, r = 0.58, p~0.004; UA/EF%, r = -0.6, p~0.006; UA/miR-499, r = -0.34; UA/miR-126, r = 0.5, p~0.01). Uric Acid 84-86 microRNA 126 Homo sapiens 247-254
27924211-6 2016 Interestingly, a strong correlation was observed between both miRNAs and uric acid (UA) levels with ventricular contractility measured as ejection fraction (EF) (miR-499/EF%, r = 0.58, p~0.004; UA/EF%, r = -0.6, p~0.006; UA/miR-499, r = -0.34; UA/miR-126, r = 0.5, p~0.01). Uric Acid 73-82 microRNA 499a Homo sapiens 162-169
27098626-6 2016 In the T2DM-CAD group, serum CXCL16 concentrations correlated positively with hs-CRP (r=0.772, P<0.001) and uric acid levels (r=0.476, P<0.01). Uric Acid 111-120 C-X-C motif chemokine ligand 16 Homo sapiens 29-35
27039371-0 2016 GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans. Uric Acid 73-82 inositol 1,4,5-trisphosphate receptor type 1 Homo sapiens 45-50
27039371-0 2016 GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans. Uric Acid 73-82 contactin 4 Homo sapiens 55-60
25649144-0 2016 Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra. Uric Acid 8-17 interleukin 1 receptor antagonist Homo sapiens 114-120
25649144-7 2016 RESULTS: The production of interleukin (IL)-1beta and IL-6 was higher in patients compared with controls and this correlated with serum urate levels. Uric Acid 136-141 interleukin 1 beta Homo sapiens 27-49
25649144-7 2016 RESULTS: The production of interleukin (IL)-1beta and IL-6 was higher in patients compared with controls and this correlated with serum urate levels. Uric Acid 136-141 interleukin 6 Homo sapiens 54-58
25649144-12 2016 CONCLUSIONS: In this study we demonstrate a mechanism through which high concentrations of uric acid (up to 50 mg/dL) influence inflammatory responses by facilitating IL-1beta production in PBMCs. Uric Acid 91-100 interleukin 1 beta Homo sapiens 167-175
27125896-6 2016 In the placenta, fructose induced de novo uric acid synthesis by activating the activities of the enzymes AMP deaminase and xanthine oxidase. Uric Acid 42-51 xanthine dehydrogenase Mus musculus 124-140
27125896-8 2016 Treatment of mothers with the xanthine oxidase inhibitor allopurinol reduced placental uric acid levels, prevented placental inefficiency, and improved fetal weights and serum triglycerides. Uric Acid 87-96 xanthine dehydrogenase Mus musculus 30-46
26979477-5 2016 Meanwhile, the as-made Silk C-IL/GCE presented good selectivity for DA detection from other possible interferences, such as ascorbic acid, glucose and uric acid. Uric Acid 151-160 glycine decarboxylase Homo sapiens 33-36
32263279-4 2016 We then demonstrated the use of this nonenzymatic nanoelectrocatalyst for individual detection, and the linear responses of DA and UA were in the concentration ranges of 100 nM-1 mM and 1 muM-1 mM with detection limits of 1.34 x 10-10 M and 1.8 x 10-6 M (S/N = 3sigma/b), respectively. Uric Acid 131-133 PWWP domain containing 3A, DNA repair factor Homo sapiens 188-193
27160127-9 2016 In men, sVAP-1 was negatively associated with apolipoprotein A (ApoA) (p < 0.01), alcohol intake (p < 0.01) and uric acid (p < 0.05), but positively associated with ApoB/ApoA (p < 0.05). Uric Acid 118-127 synaptosome associated protein 47 Homo sapiens 8-14
26639394-0 2016 Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. Uric Acid 0-9 insulin Homo sapiens 42-49
26639394-0 2016 Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 73-78
26639394-3 2016 This study aimed to investigate the effects and underlying mechanisms of uric acid on development of NAFLD and insulin resistance. Uric Acid 73-82 insulin Homo sapiens 111-118
26639394-5 2016 Subsequently, we studied the role of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in uric acid-induced fat accumulation and insulin signaling impairment. Uric Acid 116-125 NLR family pyrin domain containing 3 Homo sapiens 93-98
26639394-6 2016 RESULTS: We found that uric acid directly induces hepatocyte fat accumulation, insulin resistance, and insulin signaling impairment both in vivo and in vitro. Uric Acid 23-32 insulin Homo sapiens 79-86
26639394-7 2016 We also found that uric acid-induced NLRP3 inflammasome activation, whereas lowering uric acid by allopurinol inhibited NLRP3 inflammasome activation in a high fat diet mouse model of NAFLD. Uric Acid 19-28 NLR family, pyrin domain containing 3 Mus musculus 37-42
26639394-7 2016 We also found that uric acid-induced NLRP3 inflammasome activation, whereas lowering uric acid by allopurinol inhibited NLRP3 inflammasome activation in a high fat diet mouse model of NAFLD. Uric Acid 85-94 NLR family, pyrin domain containing 3 Mus musculus 120-125
26639394-8 2016 Moreover, knocking down NLRP3 expression significantly attenuated uric acid-induced fat accumulation both in HepG2 cells and L02 cells. Uric Acid 66-75 NLR family pyrin domain containing 3 Homo sapiens 24-29
26639394-9 2016 Knocking down NLRP3 expression also rescued uric acid-induced insulin signaling impairment in both cell types. Uric Acid 44-53 NLR family pyrin domain containing 3 Homo sapiens 14-19
26639394-10 2016 CONCLUSIONS: Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome. Uric Acid 13-22 insulin Homo sapiens 55-62
26639394-10 2016 CONCLUSIONS: Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 86-91
26639394-11 2016 Uric acid may be a new therapeutic target for NAFLD and insulin resistance. Uric Acid 0-9 insulin Homo sapiens 56-63
26824485-0 2016 Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. Uric Acid 0-9 parathyroid hormone Homo sapiens 50-69
26907620-0 2016 Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone. Uric Acid 90-95 solute carrier family 22 member 12 Homo sapiens 51-56
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 131-136
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 288-293
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 110-115 solute carrier family 22 member 12 Homo sapiens 131-136
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 110-115 solute carrier family 22 member 12 Homo sapiens 288-293
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 110-115 solute carrier family 22 member 12 Homo sapiens 131-136
26907620-2 2016 Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate transporter 1 (URAT1) and thus lower serum urate levels, they also inhibit other transporters responsible for secretion of urate into urine, which suggests that inhibiting URAT1 selectively would lower serum urate more effectively. Uric Acid 110-115 solute carrier family 22 member 12 Homo sapiens 288-293
28065878-4 2016 Controlling for the level of exercise, inverse correlations were observed for uric acid and glutathione reductase (GR) or susceptibility of red blood cells to peroxidation (RBCPx); plasma adrenaline oxidase activity (AdOx) and carotenoids; TBARS and GR or Vit E; and direct correlations were observed between AdOx and creatine kinase (CK) or TBARS; CK and superoxide dismutase activity; GR and RBCPx. Uric Acid 78-87 glutathione-disulfide reductase Homo sapiens 92-113
26824485-1 2016 BACKGROUND: Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults. Uric Acid 27-36 parathyroid hormone Homo sapiens 125-144
26810206-6 2016 RESULTS: In a 46-year-old female patient with a fractional excretion of uric acid of 3 %, analysis of the UMOD gene revealed a p.W202S missense mutation. Uric Acid 72-81 uromodulin Homo sapiens 106-110
26228073-9 2016 In addition, several clinical studies have also shown that SGLT2 inhibitors could reduce blood pressure, body weight, and serum uric acid levels and ameliorate cardiovascular risk in patients with diabetes. Uric Acid 128-137 solute carrier family 5 member 2 Homo sapiens 59-64
30234279-10 2016 Conclusions: Increased levels of serum uric acid are significantly associated with NAFLD and this association seemed to be mediated by insulin resistance among prediabetic subjects. Uric Acid 39-48 insulin Homo sapiens 135-142
26946251-3 2016 In a number of tissues, uric acid has been shown to stimulate the production of ROS via activation of transforming growth factor beta1 and NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 4. Uric Acid 24-33 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 129-134
26810206-10 2016 Genetic analysis identified a novel p.H250Q UMOD mutation that was also present in her 12-year-old son, who had normal renal function and uric acid levels. Uric Acid 138-147 uromodulin Homo sapiens 44-48
26810206-11 2016 CONCLUSION: In patients suffering from chronic tubulointerstitial nephropathy, hyperuricemia, and a low fractional excretion of uric acid mutation, analysis of the UMOD gene should be performed to diagnose UMOD-associated kidney disease. Uric Acid 128-137 uromodulin Homo sapiens 164-168
26903297-1 2016 A metabolic syndrome (MetS) is accompanied by hyperuricemia, during which xanthine oxidoreductase (XOR) catalyzes the production of uric acid. Uric Acid 132-141 xanthine dehydrogenase Mus musculus 74-97
27103454-4 2016 Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. Uric Acid 153-162 solute carrier family 2 member 9 Homo sapiens 30-36
27103454-4 2016 Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. Uric Acid 153-162 solute carrier family 22 member 11 Homo sapiens 38-46
27103454-4 2016 Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. Uric Acid 153-162 solute carrier family 22 member 12 Homo sapiens 52-60
26903297-1 2016 A metabolic syndrome (MetS) is accompanied by hyperuricemia, during which xanthine oxidoreductase (XOR) catalyzes the production of uric acid. Uric Acid 132-141 xanthine dehydrogenase Mus musculus 99-102
26032849-5 2016 The receiver-operating characteristic (ROC) analysis shows that CRP (area under the curve [AUC]: 0.59; 95% confidence interval [CI]: 0.53-0.66; P = .014) and TB (AUC: 0.58; 95% CI: 0.51-0.65; P = .019) are significantly associated with MACE but not UA (AUC: 0.61; 95% CI: 0.42-0.76; P = .083). Uric Acid 249-251 C-reactive protein Homo sapiens 64-67
26774005-6 2016 Manipulating uric acid levels through administration of allopurinol or knock-out of urate oxidase significantly altered the number of generalized seizures, decreasing and increasing them by a twofold respectively. Uric Acid 13-22 urate oxidase Mus musculus 84-97
25589513-1 2016 OBJECTIVES: Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) crystals, which are potent activators of the NLRP3 inflammasome. Uric Acid 67-83 NLR family pyrin domain containing 3 Homo sapiens 135-140
25589513-1 2016 OBJECTIVES: Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) crystals, which are potent activators of the NLRP3 inflammasome. Uric Acid 85-88 NLR family pyrin domain containing 3 Homo sapiens 135-140
26861027-2 2016 It reduces serum uric acid (sUA) levels by inhibiting the function of the transporter proteins (URAT1 and organic anion transporter 4) involved in uric acid reabsorption in the kidney. Uric Acid 17-26 solute carrier family 22 member 12 Homo sapiens 96-101
26861027-2 2016 It reduces serum uric acid (sUA) levels by inhibiting the function of the transporter proteins (URAT1 and organic anion transporter 4) involved in uric acid reabsorption in the kidney. Uric Acid 17-26 solute carrier family 22 member 11 Homo sapiens 106-133
26861027-2 2016 It reduces serum uric acid (sUA) levels by inhibiting the function of the transporter proteins (URAT1 and organic anion transporter 4) involved in uric acid reabsorption in the kidney. Uric Acid 147-156 solute carrier family 22 member 12 Homo sapiens 96-101
26861027-2 2016 It reduces serum uric acid (sUA) levels by inhibiting the function of the transporter proteins (URAT1 and organic anion transporter 4) involved in uric acid reabsorption in the kidney. Uric Acid 147-156 solute carrier family 22 member 11 Homo sapiens 106-133
26846716-0 2016 Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Uric Acid 20-29 solute carrier family 22 member 6 Rattus norvegicus 54-58
27133319-7 2016 Leptin levels correlated positively with anthropometric measurements, triglyceride, fasting glucose, C-reactive protein, and uric acid levels, and negatively with high-density lipoprotein cholesterol levels. Uric Acid 125-134 leptin Homo sapiens 0-6
27013775-5 2016 Myeloperoxidase uses other endogenous compounds, such as serotonin, urate, and l-tyrosine, as substrates. Uric Acid 68-73 myeloperoxidase Homo sapiens 0-15
26892518-11 2016 UA induced the expression of all three ENaC subunits, SGK1, and GILZ1, and increased Na(+) transport in mCCD cells. Uric Acid 0-2 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 54-58
26892518-12 2016 Phosphorylation of ERK was significantly decreased in both UA-treated mCCD cells and hyperuricemic rat kidney; this effect was prevented by Ben co-treatment. Uric Acid 59-61 Eph receptor B1 Rattus norvegicus 19-22
27119840-4 2016 It has been established that Q141K polymorphism can directly modulate BCRP-mediated allopurinol and oxypurinol efflux, the K allele is associated with a lower reduction in serum uric acid in response to allopurinol treatment. Uric Acid 178-187 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 70-74
27455760-6 2016 These surface modified pin type electrode was applied to detect low concentration of DA and successfully detect various concentration of DA from 100 muM to 1 muM with linear relationship in the presence of ascorbic acid and uric acid. Uric Acid 224-233 latexin Homo sapiens 149-152
27455760-6 2016 These surface modified pin type electrode was applied to detect low concentration of DA and successfully detect various concentration of DA from 100 muM to 1 muM with linear relationship in the presence of ascorbic acid and uric acid. Uric Acid 224-233 latexin Homo sapiens 158-161
26846716-0 2016 Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Uric Acid 20-29 ras homolog family member A Rattus norvegicus 89-93
26846716-0 2016 Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Uric Acid 106-115 solute carrier family 22 member 6 Rattus norvegicus 54-58
26846716-0 2016 Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Uric Acid 106-115 ras homolog family member A Rattus norvegicus 89-93
26846716-1 2016 To investigate how organic anion transporter (OAT)-1 is involved in uric acid nephropathy (UAN), a rat model for UAN was established and the serum uric acid, blood urea nitrogen and serum creatinine levels were all measured, and observed to be increased. Uric Acid 68-77 solute carrier family 22 member 6 Rattus norvegicus 19-52
26910779-13 2016 This study shows for the first time that a change in plasma or intracellular urate levels, possibly involving GLUT9 and a urate efflux transporter, has an impact on prostate cancer cell growth, and that lowering SUA levels in prostate cancer is likely to be therapeutically beneficial. Uric Acid 77-82 solute carrier family 2 member 9 Homo sapiens 110-115
26846716-3 2016 By treating HEK cells with monosodium urate (MSU) crystals, it was observed that the cells exhibited a reduction in OAT1 levels. Uric Acid 27-43 solute carrier family 22 member 6 Rattus norvegicus 116-120
26846716-3 2016 By treating HEK cells with monosodium urate (MSU) crystals, it was observed that the cells exhibited a reduction in OAT1 levels. Uric Acid 45-48 solute carrier family 22 member 6 Rattus norvegicus 116-120
26846716-8 2016 These observations indicated that uric acid crystals were able to reduce the OAT1 membrane distribution through activating RhoA, and that folic acid was capable of preventing MSU-induced OAT1 relocation by inhibiting the RhoA signaling pathway. Uric Acid 34-43 solute carrier family 22 member 6 Rattus norvegicus 77-81
26846716-8 2016 These observations indicated that uric acid crystals were able to reduce the OAT1 membrane distribution through activating RhoA, and that folic acid was capable of preventing MSU-induced OAT1 relocation by inhibiting the RhoA signaling pathway. Uric Acid 34-43 ras homolog family member A Rattus norvegicus 123-127
26510964-0 2016 Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid. Uric Acid 102-111 ATP binding cassette subfamily G member 2 Bos taurus 17-22
26642356-5 2016 NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice. Uric Acid 99-115 NIMA (never in mitosis gene a)-related expressed kinase 7 Mus musculus 0-4
26642356-5 2016 NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice. Uric Acid 99-115 NLR family, pyrin domain containing 3 Mus musculus 18-23
26744988-7 2016 The metabolites of purine metabolism, especially uric acid (P12) and inosine (P13), may denote their potential as targeted biomarkers related to experimental asthma. Uric Acid 49-58 CDK2 (cyclin-dependent kinase 2)-associated protein 1 Mus musculus 60-63
26744988-8 2016 The decreased plasma uric acid (P12) suggested that inflammation responses of allergic asthma inhibited the activity of xanthine oxidase in purine metabolism, and manifested the severity of asthma exacerbation. Uric Acid 21-30 CDK2 (cyclin-dependent kinase 2)-associated protein 1 Mus musculus 32-35
26744988-8 2016 The decreased plasma uric acid (P12) suggested that inflammation responses of allergic asthma inhibited the activity of xanthine oxidase in purine metabolism, and manifested the severity of asthma exacerbation. Uric Acid 21-30 xanthine dehydrogenase Mus musculus 120-136
26842652-7 2016 An increase of 100 mumol/L baseline uric acid level resulted in a decrease of 5.684 ml/min/1.73 m(2) in eGFR [95% confidence interval (CI): 7.735-3.633]. Uric Acid 36-45 CD59 molecule (CD59 blood group) Homo sapiens 87-92
26927097-9 2016 A LAL level of 0.5 was the most sensitive for detecting both histologic and noninvasive markers for disease severity, including lower white blood cell count and calcium, and elevated gamma-glutamyltransferase, creatinine, glucose, glycated hemoglobin, uric acid and coagulation function. Uric Acid 252-261 lipase A, lysosomal acid type Homo sapiens 2-5
26909964-0 2016 PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients. Uric Acid 80-89 pyruvate dehydrogenase kinase 2 Homo sapiens 0-4
26909964-0 2016 PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients. Uric Acid 80-89 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 9-14
26510964-9 2016 Both uric acid and enterolactone were substrates in vitro of the bovine ABCG2 variants and were actively secreted into milk with a two-fold increase in the milk/plasma ratio for Y/S with respect to Y/Y cows. Uric Acid 5-14 ATP binding cassette subfamily G member 2 Bos taurus 72-77
26510964-12 2016 All these findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality. Uric Acid 164-173 ATP binding cassette subfamily G member 2 Bos taurus 54-59
26454448-0 2016 Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1beta Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells. Uric Acid 22-38 interleukin 1 beta Homo sapiens 55-72
26454448-1 2016 This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production. Uric Acid 140-156 interleukin 1 beta Homo sapiens 179-196
26925116-9 2016 Multivariate logistic regression analysis including sLOX-1, MPV, GGT and uric acid levels revealed a significant association between sLOX-1 levels and CSFP (Exp (B)/OR: 1.006, 95% CI: 1.002-1.010, p = 0.001). Uric Acid 73-82 oxidized low density lipoprotein receptor 1 Homo sapiens 133-139
26454448-1 2016 This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production. Uric Acid 140-156 interleukin 1 beta Homo sapiens 198-206
26454448-1 2016 This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production. Uric Acid 158-161 interleukin 1 beta Homo sapiens 179-196
26454448-1 2016 This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production. Uric Acid 158-161 interleukin 1 beta Homo sapiens 198-206
26454448-6 2016 In THP-1 cells, treatment with MSU crystals increased NADP/NADPH ratios and IL-1beta expression, and both of these responses were potently inhibited by addition of rebamipide. Uric Acid 31-34 GLI family zinc finger 2 Homo sapiens 3-8
26454448-0 2016 Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1beta Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells. Uric Acid 22-38 caspase 1 Homo sapiens 127-136
26454448-6 2016 In THP-1 cells, treatment with MSU crystals increased NADP/NADPH ratios and IL-1beta expression, and both of these responses were potently inhibited by addition of rebamipide. Uric Acid 31-34 interleukin 1 beta Homo sapiens 76-84
26454448-0 2016 Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1beta Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells. Uric Acid 22-38 GLI family zinc finger 2 Homo sapiens 140-145
26869107-5 2016 The content of milk metabolites was significantly affected by the change in rations as milk glucose, glucose-6-phosphate, uric acid, and the ratio cholesterol: triacylglycerides increased with higher energy intake while BHBA and TAG decreased. Uric Acid 122-131 Weaning weight-maternal milk Bos taurus 15-19
26869107-6 2016 The content of some of the milk metabolites changed during 24 h day/night periods: BHBA, cholesterol, uric acid and TAG increased whereas free glucose decreased in the night period. Uric Acid 102-111 Weaning weight-maternal milk Bos taurus 27-31
26871804-9 2016 Adiponectin was negatively correlated with white blood cells and hematocrit and positively correlated with platelets, albumin, and uric acid (P < 0.001). Uric Acid 131-140 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
26359174-6 2016 RESULTS: Beyond the factors included in the definition, SLE patients with MetS have a significantly higher serum level of uric acid (6.88 +- 2.20 vs 4.45 +- 1.17, p < 0.001) and some inflammatory biomarkers such as homocysteine, IL-8, sICAM-1 or complement molecules. Uric Acid 122-131 C-X-C motif chemokine ligand 8 Homo sapiens 232-236
26823332-3 2016 The nanosized alkaline enzymosomes containing UCU/(UCU and catalase) (ESU/ESUC) in bicine buffer had better thermal, hypothermal, acid-base and proteolytic stabilities, in vitro and in vivo kinetic characteristics, and uric acid lowering effects. Uric Acid 219-228 catalase Homo sapiens 46-67
26410617-0 2016 Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout. Uric Acid 91-96 adrenoceptor beta 3 Homo sapiens 28-54
26410617-1 2016 The Arg64 allele of variant rs4994 (Trp64Arg) in the beta3-adrenergic receptor gene has been associated with increased serum urate and risk of gout. Uric Acid 125-130 adrenoceptor beta 3 Homo sapiens 53-78
26800211-0 2016 High Uric Acid (UA) Negatively Affects Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) Immunoassay. Uric Acid 5-14 acid phosphatase 5, tartrate resistant Homo sapiens 45-83
26800211-0 2016 High Uric Acid (UA) Negatively Affects Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) Immunoassay. Uric Acid 5-14 acid phosphatase 5, tartrate resistant Homo sapiens 85-93
26800211-0 2016 High Uric Acid (UA) Negatively Affects Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) Immunoassay. Uric Acid 16-18 acid phosphatase 5, tartrate resistant Homo sapiens 45-83
26800211-0 2016 High Uric Acid (UA) Negatively Affects Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) Immunoassay. Uric Acid 16-18 acid phosphatase 5, tartrate resistant Homo sapiens 85-93
26800211-3 2016 Here, we reported that high concentrations of uric acid (UA) lead to decrease of TRACP 5b levels and determined whether TRACP 5b level was associated with UA in interference experiment. Uric Acid 46-55 acid phosphatase 5, tartrate resistant Homo sapiens 81-89
26800211-3 2016 Here, we reported that high concentrations of uric acid (UA) lead to decrease of TRACP 5b levels and determined whether TRACP 5b level was associated with UA in interference experiment. Uric Acid 57-59 acid phosphatase 5, tartrate resistant Homo sapiens 81-89
26800211-3 2016 Here, we reported that high concentrations of uric acid (UA) lead to decrease of TRACP 5b levels and determined whether TRACP 5b level was associated with UA in interference experiment. Uric Acid 155-157 acid phosphatase 5, tartrate resistant Homo sapiens 120-128
26800211-4 2016 METHODS: A total of 77 patients with high concentrations of UA and 77 healthy subjects were tested to evaluate the differences in their TRACP 5b levels. Uric Acid 60-62 acid phosphatase 5, tartrate resistant Homo sapiens 136-144
26800211-6 2016 A correction equation was set to eliminate UA-derived TRACP 5b false-decrease. Uric Acid 43-45 acid phosphatase 5, tartrate resistant Homo sapiens 54-62
26800211-10 2016 Application of the UA correction equation resulted in a statistically non-significant difference in TRACP 5b values between the healthy subjects and high-UA individuals (p = 0.24). Uric Acid 19-21 acid phosphatase 5, tartrate resistant Homo sapiens 100-108
26800211-11 2016 CONCLUSIONS: High UA concentrations can falsely decrease TRACP 5b levels due to a method-related systematic error. Uric Acid 18-20 acid phosphatase 5, tartrate resistant Homo sapiens 57-65
26645868-1 2016 Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Uric Acid 0-9 insulin Homo sapiens 100-107
26821810-0 2016 The effects of URAT1/SLC22A12 nonfunctional variants, R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression. Uric Acid 79-88 solute carrier family 22 member 12 Homo sapiens 15-20
26755550-5 2016 Among Fontan patients, galectin-3 was positively correlated with age, uric acid, and high-sensitivity C-reactive protein and negatively correlated with estimated glomerular filtration rate. Uric Acid 70-79 galectin 3 Homo sapiens 23-33
29736450-7 2016 However, treatment with simvastatin increased the plasma levels of erythropoietin (Epo) (4.2 +- 2.2 mIU/mL to 6.8 +- 3.2 mlU/mL, p < 0.05) and reduced those of serum uric acid (7.1 +- 1.3 mg/dL to 6.5 +- 1.4 mg/dL, p < 0.01). Uric Acid 169-178 erythropoietin Homo sapiens 67-81
29736450-7 2016 However, treatment with simvastatin increased the plasma levels of erythropoietin (Epo) (4.2 +- 2.2 mIU/mL to 6.8 +- 3.2 mlU/mL, p < 0.05) and reduced those of serum uric acid (7.1 +- 1.3 mg/dL to 6.5 +- 1.4 mg/dL, p < 0.01). Uric Acid 169-178 erythropoietin Homo sapiens 83-86
26728949-14 2016 CONCLUSIONS: Prokineticin-2 is correlated with various cardiometabolic risk factors including blood lipid, blood glucose, blood pressure, BMI, and uric acid. Uric Acid 147-156 prokineticin 2 Homo sapiens 13-27
26683887-8 2016 The fractional excretions of urate and sodium showed a strong positive correlation with uromodulin, likely linked to the extracellular volume status. Uric Acid 29-34 uromodulin Homo sapiens 88-98
26683887-9 2016 The presence of glycosuria and the use of uricosuric drugs, which both increased the fraction excretion of urate, were independently associated with a lower uromodulin excretion, suggesting novel interactions between uric acid and uromodulin excretion. Uric Acid 217-226 uromodulin Homo sapiens 157-167
26683887-11 2016 The strongest associations were between uric acid, sodium, and uromodulin excretions and are likely linked to the extracellular volume status. Uric Acid 40-49 uromodulin Homo sapiens 63-73
26728949-7 2016 RESULTS: The participants with serum prokineticin-2 levels >6.32 ng/ml had increased waist circumference, body mass index (BMI), plasma triglyceride, diastolic blood pressure (DBP), blood glucose, and serum uric acid, but decreased age, plasma high-density lipoprotein cholesterol (HDL-C), and HDL-C/total cholesterol (TC) (all P < 0.05). Uric Acid 210-219 prokineticin 2 Homo sapiens 37-51
27535254-5 2016 Monosodium urate crystals act as danger activating molecular patterns (DAMPs), activating the inflammasome and inducing the secretion of IL-1beta, a key mediator of the inflammatory response. Uric Acid 0-16 interleukin 1 beta Homo sapiens 137-145
25187157-12 2016 There was obvious inconsistency of gout association at four loci (GCKR, INHBC, SLC22A11, SLC16A9) that display very similar effects on urate levels. Uric Acid 135-140 glucokinase regulator Homo sapiens 66-70
25362043-4 2016 Hence, we tested the hypothesis that AMPK activation limits monosodium urate (MSU) crystal-induced inflammation. Uric Acid 78-81 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 37-41
25362043-4 2016 Hence, we tested the hypothesis that AMPK activation limits monosodium urate (MSU) crystal-induced inflammation. Uric Acid 60-76 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 37-41
25187157-12 2016 There was obvious inconsistency of gout association at four loci (GCKR, INHBC, SLC22A11, SLC16A9) that display very similar effects on urate levels. Uric Acid 135-140 solute carrier family 16 member 9 Homo sapiens 89-96
25344431-1 2016 OBJECTIVE: Verify the role of the kinin B1 receptors (B1R) and the effect of ACE inhibitors (ACEi) on acute gout induced by monosodium urate (MSU) crystals in rodents. Uric Acid 142-145 angiotensin I converting enzyme Homo sapiens 77-80
25362043-2 2016 Gout is commonly associated with excesses in soluble urate and in nutrition, both of which suppress tissue AMPK activity. Uric Acid 53-58 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 107-111
26965771-6 2016 Insulin resistance correlated significantly with body fat and trunk fat percentages, age, liver enzymes, gammaGT, and uric acid in obese children. Uric Acid 118-127 insulin Homo sapiens 0-7
26820798-9 2016 RESULTS: Variables predicted components of MetS in children: HOMA-IR (insulin resistance by HOMA index) was increased by 2.4 in hepatic steatosis, by 0.6 for each unit of SUA (serum uric acid), and by 0.009 for every mg/dL of triglycerides. Uric Acid 182-191 insulin Homo sapiens 70-77
26531064-3 2016 Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils. Uric Acid 195-211 mixed lineage kinase domain like pseudokinase Homo sapiens 120-152
26561271-1 2016 Uricase is the enzyme responsible for the breakdown of uric acid, the key molecule leading to gout in humans, into allantoin, but it is absent in humans. Uric Acid 55-64 urate oxidase (pseudogene) Homo sapiens 0-7
27689075-13 2016 Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions. Uric Acid 32-48 NLR family pyrin domain containing 3 Homo sapiens 97-102
27689075-13 2016 Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions. Uric Acid 32-48 interleukin 1 beta Homo sapiens 107-115
27889764-0 2016 High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1. Uric Acid 5-14 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 33-37
27889764-0 2016 High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1. Uric Acid 5-14 CD68 molecule Homo sapiens 55-59
27889764-0 2016 High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1. Uric Acid 5-14 GLI family zinc finger 2 Homo sapiens 150-155
26711273-8 2016 Moreover, UA prevents the increase in the circulating levels of the lipid peroxidation marker malondialdehyde and of active matrix metalloproteinase (MMP) 9, a marker of blood-brain barrier disruption. Uric Acid 10-12 matrix metallopeptidase 9 Homo sapiens 124-156
26449770-1 2016 Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. Uric Acid 99-115 NLR family, pyrin domain containing 3 Mus musculus 184-189
26531064-3 2016 Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils. Uric Acid 195-211 mixed lineage kinase domain like pseudokinase Homo sapiens 154-158
26449770-1 2016 Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. Uric Acid 117-120 NLR family, pyrin domain containing 3 Mus musculus 184-189
26531064-3 2016 Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils. Uric Acid 213-216 mixed lineage kinase domain like pseudokinase Homo sapiens 120-152
26449770-10 2016 In conclusion, TNF-alpha drives expression of pro-IL-1beta mRNA and IL-1beta protein in experimental gout and that its transmembrane form is sufficient to trigger MSU-induced inflammation in mice. Uric Acid 163-166 tumor necrosis factor Mus musculus 15-24
26531064-3 2016 Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils. Uric Acid 213-216 mixed lineage kinase domain like pseudokinase Homo sapiens 154-158
26942273-2 2016 Its inhibition of XOR is more potent than allopurinol in a mg to mg comparison, what is associated to achievement of serum urate target more frequently than allopurinol at doses tested in clinical trials, especially in patients with the highest baseline serum urate levels. Uric Acid 123-128 xanthine dehydrogenase Homo sapiens 18-21
26942273-2 2016 Its inhibition of XOR is more potent than allopurinol in a mg to mg comparison, what is associated to achievement of serum urate target more frequently than allopurinol at doses tested in clinical trials, especially in patients with the highest baseline serum urate levels. Uric Acid 260-265 xanthine dehydrogenase Homo sapiens 18-21
26550697-1 2016 This study examined the relationship between serum levels of uric acid and insulin resistance and metabolic syndrome in nondiabetic patients with schizophrenia. Uric Acid 61-70 insulin Homo sapiens 75-82
26550697-5 2016 A significant positive relationship was found between serum levels of uric acid and the homeostasis model of assessing insulin resistance (log transformed, r=0.394, P<0.001), and a significant negative relationship was found between serum levels of uric acid and low-density lipoprotein particle size (log transformed, r=-0.306, P=0.001) after controlling for potential confounding variables. Uric Acid 70-79 insulin Homo sapiens 119-126
26550697-6 2016 Hierarchical multiple regression suggested that serum uric acid level is a significant predictor of insulin resistance (P=0.001) and of low-density lipoprotein particle size (P<0.015). Uric Acid 54-63 insulin Homo sapiens 100-107
27489597-9 2016 In comparison with normal UA group, high UA group had significantly higher cTnI (2.68+-0.09 vs 4.09+-0.42, respectively, P=0.001), increased blood pressure (P=0.009), and higher atrial fibrillation (AF) occurrence (P=0.03), but no association was seen between ventricular tachycardia and serum UA level. Uric Acid 41-43 troponin I3, cardiac type Homo sapiens 75-79
27489597-9 2016 In comparison with normal UA group, high UA group had significantly higher cTnI (2.68+-0.09 vs 4.09+-0.42, respectively, P=0.001), increased blood pressure (P=0.009), and higher atrial fibrillation (AF) occurrence (P=0.03), but no association was seen between ventricular tachycardia and serum UA level. Uric Acid 41-43 troponin I3, cardiac type Homo sapiens 75-79
27489597-11 2016 CONCLUSION: In the current study, high serum UA level in patients with acute myocardial infarction (MI) was not associated with higher in-hospital or midterm mortality, but it was associated with lower LVEF, higher Killip class, elevated cTnI, creatinine, triglyceride, and higher AF. Uric Acid 45-47 troponin I3, cardiac type Homo sapiens 238-242
27642607-11 2016 There were also positive correlations between GDF-15 and age, uric acid, creatinine, and area under the curve for glucose (AUC-G). Uric Acid 62-71 growth differentiation factor 15 Homo sapiens 46-52
26673227-5 2016 [(15)N2]-UA production by XOR was dependent on the amounts of [(15)N2]-xanthine and enzyme and the time of reaction. Uric Acid 9-11 xanthine dehydrogenase Mus musculus 26-29
27403443-10 2016 The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. Uric Acid 21-30 insulin Homo sapiens 79-86
27403443-13 2016 The negative correlation between uric acid and HbA1c is conditional in newly diagnosed type 2 diabetes patients and is related to hyperinsulinemia. Uric Acid 33-42 hemoglobin subunit alpha 1 Homo sapiens 47-51
26589240-0 2016 Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor. Uric Acid 38-43 xanthine dehydrogenase Rattus norvegicus 110-133
27642607-13 2016 In the multiple regression analysis, GDF-15 concentrations were independently associated with age, uric acid, and AUC-G. Uric Acid 99-108 growth differentiation factor 15 Homo sapiens 37-43
26914454-0 2016 The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy. Uric Acid 29-38 IGAN1 Homo sapiens 87-102
26914454-8 2016 Serum uric acid level was associated independently with T score (beta=0.303, p=0.005) in patients with eGFR>30 ml/min/m2. Uric Acid 6-15 epidermal growth factor receptor Homo sapiens 103-107
27561821-7 2016 CONCLUSION: High urinary fractional excretion of uric acid in SLN is associated with elevated NGAL and fasting urinary fructose levels suggesting that SLN may involve tubular injury. Uric Acid 49-58 lipocalin 2 Homo sapiens 94-98
27010539-7 2016 In anesthetized mice, medullary infusion of Nlrp3 inflammasome activator, monosodium urate (MSU), induced significant decreases in sodium excretion and medullary blood flow without changes in mean arterial blood pressure and renal cortical blood flow. Uric Acid 74-90 NLR family, pyrin domain containing 3 Mus musculus 44-49
27010539-7 2016 In anesthetized mice, medullary infusion of Nlrp3 inflammasome activator, monosodium urate (MSU), induced significant decreases in sodium excretion and medullary blood flow without changes in mean arterial blood pressure and renal cortical blood flow. Uric Acid 92-95 NLR family, pyrin domain containing 3 Mus musculus 44-49
27010539-8 2016 Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF. Uric Acid 77-80 caspase 1 Mus musculus 0-9
27010539-8 2016 Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF. Uric Acid 77-80 NLR family, pyrin domain containing 3 Mus musculus 49-54
27010539-8 2016 Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF. Uric Acid 77-80 steroid sulfatase Mus musculus 58-61
27010539-8 2016 Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF. Uric Acid 77-80 rhotekin 2 Mus musculus 129-132
26823950-1 2016 Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. Uric Acid 117-126 xanthine dehydrogenase Homo sapiens 0-23
26138228-8 2016 The number of mutant spots increased significantly in an exposure time-dependent manner in the urate-null females (ma-l (-/-)), but not in the urate-positive females (ma-l (+/-)). Uric Acid 95-100 maroon-like Drosophila melanogaster 115-119
26823950-1 2016 Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. Uric Acid 117-126 xanthine dehydrogenase Homo sapiens 25-28
27455597-9 2016 Among them - the increase in the activity of key enzymes I and II stages of detoxification of xenobiotics, indicating its functional overvoltage; reducing the activity of glutathione peroxidase (GP), the total arylsulfatase A and B, beta-galactosidase (in the absence of changes in their non-sedimentable activity), levels of uric acid, increased alkaline phosphatase activity. Uric Acid 326-335 arylsulfatase A Rattus norvegicus 210-231
26635913-7 2016 We detected negative correlations between SOD and pressure wave velocity, peripheral and central augmentation index and ambulatory arterial stiffness index, pulse pressure, and plasma HDL-cholesterol, as well as positive correlations between SOD and plasma uric acid and triglycerides. Uric Acid 257-266 superoxide dismutase 1 Homo sapiens 242-245
26681956-2 2016 To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS and xanthine oxidase (XO) levels. Uric Acid 143-152 heme oxygenase 1 Homo sapiens 84-100
26681956-4 2016 Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis markers C/EBPalpha, PPARgamma, and Mest, while decreasing small lipid droplets and Wnt10b levels. Uric Acid 0-9 CCAAT enhancer binding protein alpha Homo sapiens 114-124
26681956-4 2016 Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis markers C/EBPalpha, PPARgamma, and Mest, while decreasing small lipid droplets and Wnt10b levels. Uric Acid 0-9 peroxisome proliferator activated receptor gamma Homo sapiens 126-135
26681956-4 2016 Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis markers C/EBPalpha, PPARgamma, and Mest, while decreasing small lipid droplets and Wnt10b levels. Uric Acid 0-9 mesoderm specific transcript Homo sapiens 141-145
26681956-4 2016 Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis markers C/EBPalpha, PPARgamma, and Mest, while decreasing small lipid droplets and Wnt10b levels. Uric Acid 0-9 Wnt family member 10B Homo sapiens 189-195
26571421-0 2015 Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. Uric Acid 9-18 insulin Homo sapiens 45-52
26593216-17 2015 Flavonoids mainly accountable for the uric acid lowering effect of L. nodiflora through the inhibition of XOD/XDH activities. Uric Acid 38-47 xanthine dehydrogenase Rattus norvegicus 110-113
26571421-2 2015 Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance. Uric Acid 44-53 insulin Homo sapiens 106-113
26546608-4 2015 Additionally, the NLRP3 activators nigericin and monosodium urate crystals lowered iATP through K(+)- and Ca(2+)-mediated mitochondrial dysfunction, suggesting a feedback loop between iATP loss and lowering of mitochondrial membrane potential. Uric Acid 49-65 NLR family pyrin domain containing 3 Homo sapiens 18-23
26344851-0 2015 Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice. Uric Acid 32-41 xanthine dehydrogenase Mus musculus 56-72
26163998-6 2015 There were significant correlations in PAH group between IL-6 levels and uric acid, parameters of ventilatory efficiency in cardiopulmonary exercise testing: VE/VO2, VE/VCO2, VE/VCO2 slope and peak PetCO2. Uric Acid 73-82 interleukin 6 Homo sapiens 57-61
26571421-6 2015 RESULTS: Allopurinol-treated subjects showed a reduction in serum uric acid in association with improvement in fasting blood glucose, fasting insulin, and HOMA-IR index, as well as a reduction in serum high-sensitivity C-reactive protein. Uric Acid 66-75 insulin Homo sapiens 142-149
26607700-1 2015 INTRODUCTION: The strongest genetic marker of uric acid levels, the rs734553 SNP in the GLUT9 urate transporter gene, predicts progression to kidney failure in CKD patients and associates with systolic BP and carotid intima media thickness in family-based studies. Uric Acid 46-55 solute carrier family 2 member 9 Homo sapiens 88-93
26185050-8 2015 The overall adjusted change in decline in renal function per unit increase in baseline UA was 0.08 (95% CI -0.01; 0.17) mL/min/1.73 m(2) per year indicating no association between higher UA levels and decline in renal function. Uric Acid 87-89 CD59 molecule (CD59 blood group) Homo sapiens 123-128
26135139-6 2015 Measures of adiposity, low high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, LVM and LVH were all significantly associated with elevated UA at baseline, but not with change over time. Uric Acid 162-164 C-reactive protein Homo sapiens 82-100
25864117-1 2015 OBJECTIVE: To explore the effect of Compound Tufuling Granules ([characters: see text], CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and serum uric acid (SUA) level in hyperuricemia mice. Uric Acid 223-232 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 130-135
26603249-0 2015 Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1. Uric Acid 54-63 solute carrier family 22 member 12 Homo sapiens 13-18
26603249-0 2015 Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1. Uric Acid 54-63 solute carrier family 22 member 12 Homo sapiens 75-80
26603249-1 2015 OBJECTIVES: Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. Uric Acid 168-177 solute carrier family 22 member 12 Homo sapiens 18-37
26603249-1 2015 OBJECTIVES: Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. Uric Acid 168-177 solute carrier family 22 member 12 Homo sapiens 39-44
26603249-1 2015 OBJECTIVES: Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. Uric Acid 168-177 solute carrier family 22 member 12 Homo sapiens 99-107
26603249-14 2015 CONCLUSIONS: These results indicate that five newly described SNPs in the hURAT1 gene are significantly associated with uric acid level (4-2008-0318 and 4-2011-0277). Uric Acid 120-129 solute carrier family 22 member 12 Homo sapiens 74-80
26377792-11 2015 In addition to cGMP, OAT2 transported urate and glutamate, but cGMP/glutamate exchange could not be demonstrated. Uric Acid 38-43 solute carrier family 22 member 7 Homo sapiens 21-25
26284320-8 2015 RESULTS: Rs1109303 (T>G) variant within the INPP5K gene on chromosome 17p13.3 demonstrated a genome-wide significant interaction with serum urate level to predict striatal dopamine transporter density among all PPMI participants (n = 359) with possible PD (p = 2.01 x 10(-8) ; after excluding participants with SWEDD [scan without evidence of dopaminergic deficit]: p = 1.12 x 10(-9) ; n = 316). Uric Acid 140-145 inositol polyphosphate-5-phosphatase K Homo sapiens 44-50
26284320-8 2015 RESULTS: Rs1109303 (T>G) variant within the INPP5K gene on chromosome 17p13.3 demonstrated a genome-wide significant interaction with serum urate level to predict striatal dopamine transporter density among all PPMI participants (n = 359) with possible PD (p = 2.01 x 10(-8) ; after excluding participants with SWEDD [scan without evidence of dopaminergic deficit]: p = 1.12 x 10(-9) ; n = 316). Uric Acid 140-145 solute carrier family 6 member 3 Homo sapiens 172-192
26284320-10 2015 No effect was present in the PRECEPT sample at baseline; however, in non-SWEDD PD participants in PRECEPT (n = 309), we observed a significant longitudinal genotype x serum urate interaction effect, consistent in direction with the PPMI sample, on progression of striatal dopamine transporter density over the 22-month follow-up. Uric Acid 173-178 solute carrier family 6 member 3 Homo sapiens 272-292
26300523-0 2015 [The role of uric acid in the insulin resistance in children and adolescents with obesity]. Uric Acid 13-22 insulin Homo sapiens 30-37
26300523-1 2015 OBJECTIVE: To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity. Uric Acid 56-65 insulin Homo sapiens 77-84
26300523-5 2015 To evaluate the association between uric acid levels and insulin resistance the Pearson"s test and logistic regression were applied. Uric Acid 36-45 insulin Homo sapiens 57-64
26300523-9 2015 The logistic regression model that included age, gender and obesity, showed an odds ratio of uric acid as a variable associated with insulin resistance of 1.91 (95%CI 1.40 to 2.62; p<-0.001). Uric Acid 93-102 insulin Homo sapiens 133-140
26300523-10 2015 CONCLUSIONS: The increase in serum uric acid showed a positive statistical correlation with insulin resistance and it is associated with and increased risk of insulin resistance in obese children and adolescents. Uric Acid 35-44 insulin Homo sapiens 92-99
26300523-10 2015 CONCLUSIONS: The increase in serum uric acid showed a positive statistical correlation with insulin resistance and it is associated with and increased risk of insulin resistance in obese children and adolescents. Uric Acid 35-44 insulin Homo sapiens 159-166
26623003-9 2015 The CART model suggested different variables of hypertension, mean cell volume, fasting blood sugar, cholesterol, triglyceride and uric acid concentration based on middle-aged and elderly patients at high risk for MI. Uric Acid 131-140 CART prepropeptide Homo sapiens 4-8
26635798-5 2015 Treatment with the immunostimulatory agents monosodium urate crystals and Mycobacterium smegmatis induced the accumulation of monocytes in the dLN, their upregulation of CD11c and MHCII, and expression of iNOS, TNFalpha, and IL12p40. Uric Acid 44-60 integrin subunit alpha X Homo sapiens 170-175
26342044-10 2015 Serum uric acid was significantly associated with albuminuria only in presence of eGFR <60 ml/min per 1.73 m2. Uric Acid 6-15 epidermal growth factor receptor Homo sapiens 82-86
26524967-2 2015 SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Uric Acid 117-126 solute carrier family 17 member 1 Homo sapiens 0-7
25864117-0 2015 Compound Tufuling Granules ([characters: see text]) regulate glucose transporter 9 expression in kidney to influence serum uric acid level in hyperuricemia mice. Uric Acid 123-132 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 61-82
25864117-1 2015 OBJECTIVE: To explore the effect of Compound Tufuling Granules ([characters: see text], CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and serum uric acid (SUA) level in hyperuricemia mice. Uric Acid 179-188 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 107-128
25864117-1 2015 OBJECTIVE: To explore the effect of Compound Tufuling Granules ([characters: see text], CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and serum uric acid (SUA) level in hyperuricemia mice. Uric Acid 179-188 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 130-135
25864117-1 2015 OBJECTIVE: To explore the effect of Compound Tufuling Granules ([characters: see text], CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and serum uric acid (SUA) level in hyperuricemia mice. Uric Acid 223-232 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 107-128
25864117-9 2015 In addition, CTG can effectively inhibit the mRNA and protein expressions of GLUT9 in the kidney of hyperuricemia mice to inhibit the uric acid re-absorption, promote uric acid excretion and reduce SUA. Uric Acid 134-143 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 77-82
25864117-9 2015 In addition, CTG can effectively inhibit the mRNA and protein expressions of GLUT9 in the kidney of hyperuricemia mice to inhibit the uric acid re-absorption, promote uric acid excretion and reduce SUA. Uric Acid 167-176 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 77-82
26100496-7 2015 Depletion of uric acid or ATP, or lack of ATP signaling attenuated ASH and prevented inflammasome activation and its major downstream cytokine, IL-1beta. Uric Acid 13-22 interleukin 1 beta Mus musculus 144-152
25788532-6 2015 Furthermore, gefitinib treatment suppressed xanthine oxidase activity, which mediates uric acid production, and preserved expression of organic anion transporters 1 and 3, which promotes uric acid excretion in the kidney of hyperuricemic rats. Uric Acid 187-196 solute carrier family 22 member 6 Rattus norvegicus 136-170
25788532-7 2015 Thus, blocking EGFR can attenuate development of HN via suppression of TGF-beta1 signaling and inflammation and promotion of the molecular processes that reduce uric acid accumulation in the body. Uric Acid 161-170 epidermal growth factor receptor Rattus norvegicus 15-19
26636527-7 2015 In ITP patients, serum UA and CRP levels significantly correlated with low platelet count (r = -0.362, p = 0.022; r = -0.383, p = 0.015, respectively); and UA levels significantly correlated with CRP levels (r = 0.436, p = 0.005). Uric Acid 23-25 C-reactive protein Homo sapiens 196-199
25806469-5 2015 At Cox regression analysis, uric acid was an independent predictor of 1-year postdischarge mortality (hazard ratio 1.26, 95% confidence interval 1.06-1.51, P = 0.011).In STEMI patients with estimated glomerular filtration rate below 60 ml/min/1.73 m treated with PCI, uric acid helps in identifying a subset of patients at a higher risk of bleeding and acute kidney injury. Uric Acid 28-37 CD59 molecule (CD59 blood group) Homo sapiens 239-244
26100496-8 2015 Pharmacological depletion of uric acid with allopurinol provided significant protection from alcohol-induced inflammatory response, steatosis and liver damage, and additional protection was achieved in mice treated with probenecid, which depletes uric acid and blocks ATP-induced P2rx7 signaling. Uric Acid 29-38 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 280-285
26100496-10 2015 CONCLUSIONS: Our data indicate that the second signal in inflammasome activation and IL-1beta production in ASH results from the endogenous danger signals, uric acid and ATP. Uric Acid 156-165 interleukin 1 beta Mus musculus 85-93
26249610-3 2015 The resulting sensor exhibited a good response to hydrogen peroxide over linear range from 0.2 to 60.0muM with a limit of detection of 0.08muM, good reproducibility, long-term stability and negligible interference from ascorbic acid, uric acid and dopamine. Uric Acid 234-243 latexin Homo sapiens 102-105
25845417-0 2015 The association between the serum levels of uric acid and alanine aminotransferase in a population-based cohort. Uric Acid 44-53 glutamic--pyruvic transaminase Homo sapiens 58-82
25845417-3 2015 Therefore, we aimed to test the association between uric acid and elevated alanine aminotransferase (ALT), as a surrogate for NAFLD, using real-world data. Uric Acid 52-61 glutamic--pyruvic transaminase Homo sapiens 75-99
26282945-8 2015 Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. Uric Acid 75-84 NLR family pyrin domain containing 3 Homo sapiens 104-109
26179893-6 2015 Second, in a stasis VT mouse model, endogenous danger signal mediators of uric acid, HMGB-1, and neutrophil extracellular traps marker of citrullinated histone-3 (and extracellular DNA) were greater in Tlr9-/- thrombi as compared with wild-type (WT), corresponding with larger VT at 8 and 21 days. Uric Acid 74-83 toll-like receptor 9 Mus musculus 202-206
26554771-1 2015 Single nucleotide polymorphisms (SNPs) at the glucose transporter 9 (GLUT9) locus are clearly related to uric acid concentrations previously identified as a major cause of gout. Uric Acid 105-114 solute carrier family 2 member 9 Homo sapiens 46-67
26554771-1 2015 Single nucleotide polymorphisms (SNPs) at the glucose transporter 9 (GLUT9) locus are clearly related to uric acid concentrations previously identified as a major cause of gout. Uric Acid 105-114 solute carrier family 2 member 9 Homo sapiens 69-74
26528330-0 2015 Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women. Uric Acid 68-73 solute carrier family 2 member 9 Homo sapiens 15-21
26528330-1 2015 The SLC2A9 gene, that encodes a renal uric acid reuptake transporter, has genetic variants that explain ~3% of variance in urate levels. Uric Acid 123-128 solute carrier family 2 member 9 Homo sapiens 4-10
26528330-2 2015 There are previous reports of non-additive interaction between SLC2A9 genotype and environmental factors which influence urate control. Uric Acid 121-126 solute carrier family 2 member 9 Homo sapiens 63-69
26528330-6 2015 Variant rs6449173 showed the most significant effect on serum urate variance at SLC2A9 (P = 7.9 x 10(-14)), which was maintained after accounting for the effect on average serum urate levels (P = 0.022). Uric Acid 62-67 solute carrier family 2 member 9 Homo sapiens 80-86
26528330-6 2015 Variant rs6449173 showed the most significant effect on serum urate variance at SLC2A9 (P = 7.9 x 10(-14)), which was maintained after accounting for the effect on average serum urate levels (P = 0.022). Uric Acid 178-183 solute carrier family 2 member 9 Homo sapiens 80-86
26528330-11 2015 Female hormones, and/or other factors they influence or are associated with (such as iron levels, temperature, testosterone) interact with SLC2A9 genotype in women to determine urate levels. Uric Acid 177-182 solute carrier family 2 member 9 Homo sapiens 139-145
26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 119-135 NLR family pyrin domain containing 3 Homo sapiens 4-38
26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 119-135 NLR family pyrin domain containing 3 Homo sapiens 40-45
26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 137-140 NLR family pyrin domain containing 3 Homo sapiens 4-38
26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 137-140 NLR family pyrin domain containing 3 Homo sapiens 40-45
26116704-2 2015 We investigated the role of P2 purinergic receptors in the activation of NLRP3-inflammasome pathway after MSU treatment of primary human monocyte-derived macrophages (MDMs). Uric Acid 106-109 NLR family pyrin domain containing 3 Homo sapiens 73-78
26206452-10 2015 Urinary UA excretion increased with animal protein intake and cystatin C estimated glomerular filtration rate (eGFR) and was lower with concurrent loop diuretic use. Uric Acid 8-10 cystatin C Homo sapiens 62-72
26238426-0 2015 Peroxisome proliferator-activated receptor gamma prevents the production of NOD-like receptor family, pyrin domain containing 3 inflammasome and interleukin 1beta in HK-2 renal tubular epithelial cells stimulated by monosodium urate crystals. Uric Acid 216-232 peroxisome proliferator activated receptor gamma Homo sapiens 0-48
26238426-0 2015 Peroxisome proliferator-activated receptor gamma prevents the production of NOD-like receptor family, pyrin domain containing 3 inflammasome and interleukin 1beta in HK-2 renal tubular epithelial cells stimulated by monosodium urate crystals. Uric Acid 216-232 interleukin 1 beta Homo sapiens 145-162
26238426-2 2015 The present study aimed to investigate the role of PPARgamma in regulating NOD-like receptor family, pyrin domain containing 3 (NALP3) inflammasome and interleukin (IL)-1beta levels during monosodium urate (MSU) crystal-induced inflammation. Uric Acid 189-205 peroxisome proliferator activated receptor gamma Homo sapiens 51-60
26238426-2 2015 The present study aimed to investigate the role of PPARgamma in regulating NOD-like receptor family, pyrin domain containing 3 (NALP3) inflammasome and interleukin (IL)-1beta levels during monosodium urate (MSU) crystal-induced inflammation. Uric Acid 189-205 NLR family pyrin domain containing 3 Homo sapiens 128-133
26238426-2 2015 The present study aimed to investigate the role of PPARgamma in regulating NOD-like receptor family, pyrin domain containing 3 (NALP3) inflammasome and interleukin (IL)-1beta levels during monosodium urate (MSU) crystal-induced inflammation. Uric Acid 207-210 peroxisome proliferator activated receptor gamma Homo sapiens 51-60
25916483-7 2015 converted uric acid into ammonium, which stimulated growth of microbial consortia dominated by Alcanivorax spp. Uric Acid 10-19 histocompatibility minor 13 Homo sapiens 107-110
25361999-5 2015 Whereas nutrients that stimulate generation of uric acid (such as fructose and purine-rich food) cause insulin resistance and fat accumulation, other nutrients (such as antioxidants, plant food, probiotics, nuts, soy and omega-3) counteract the negative effects of a calorie-rich diet by salutary effects on mitochondrial biogenesis. Uric Acid 47-56 insulin Homo sapiens 103-110
26341543-4 2015 Urate treatment also induced the nuclear translocation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein and transcriptional activation of its key target genes in primary astrocytic cultures. Uric Acid 0-5 NFE2 like bZIP transcription factor 2 Homo sapiens 62-105
26341543-4 2015 Urate treatment also induced the nuclear translocation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein and transcriptional activation of its key target genes in primary astrocytic cultures. Uric Acid 0-5 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111
26341543-7 2015 These results also show that urate can employ a novel indirect neuroprotective mechanism via induction of the Nrf2 signaling pathway, a master regulator of the response to oxidative stress, in astrocytes. Uric Acid 29-34 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114
26208844-7 2015 The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively. Uric Acid 4-13 solute carrier family 22 member 12 Homo sapiens 102-121
26208844-7 2015 The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively. Uric Acid 4-13 solute carrier family 22 member 12 Homo sapiens 123-129
26208844-7 2015 The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively. Uric Acid 4-13 solute carrier family 22 member 6 Homo sapiens 132-164
26208844-7 2015 The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively. Uric Acid 4-13 solute carrier family 22 member 8 Homo sapiens 168-172
26208844-7 2015 The uric acid-, indoxyl sulfate-, and methylguanidine-depolarized RVLM neurons showed the presence of urate transporter 1 (URAT 1), organic anion transporter (OAT)1 or OAT3, and organic cation transporter (OCT)3, respectively. Uric Acid 4-13 solute carrier family 22 member 3 Homo sapiens 206-211
26136557-0 2015 ABCG2: the molecular mechanisms of urate secretion and gout. Uric Acid 35-40 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
26119820-7 2015 Pre-administration of allopurinol recovered the BCRP homodimer level, resulting in the recovering ileal uric acid clearance. Uric Acid 104-113 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 48-52
26344078-7 2015 RESULTS: MSU crystals induced adhesion of eosinophils to recombinant human (rh)-ICAM-1 and induced production of superoxide. Uric Acid 9-12 intercellular adhesion molecule 1 Homo sapiens 80-86
26133655-6 2015 Hyperuricaemia reduction in the Pound mouse or fructose-fed rats, as well as hyperuricaemia induction by uricase inhibition in rodents and studies using cell culture have suggested that uric acid plays an important role in the development of metabolic syndrome. Uric Acid 186-195 urate oxidase Rattus norvegicus 105-112
26133655-8 2015 Humans lacking uricase, the enzyme responsible for uric acid degradation, are susceptible to these effects. Uric Acid 51-60 urate oxidase (pseudogene) Homo sapiens 15-22
26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 82-98 NLR family pyrin domain containing 3 Homo sapiens 4-9
26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 82-98 GLI family zinc finger 2 Homo sapiens 123-128
26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 100-103 NLR family pyrin domain containing 3 Homo sapiens 4-9
26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 100-103 GLI family zinc finger 2 Homo sapiens 123-128
26349049-7 2015 Gene deletion in a PuuD-encoding organism (Agrobacterium fabrum) abolished urate degradation capacity; the phenotype was fully restored by complementation with a cytosolic Uox from zebrafish. Uric Acid 75-80 urate oxidase (pseudogene) Homo sapiens 172-175
26349049-8 2015 Consistent with H2O2 production by zfUox, urate oxidation in the complemented strain caused a four-fold increase of catalase. Uric Acid 42-47 catalase Homo sapiens 116-124
26349049-9 2015 No increase was observed in the wild-type, suggesting that urate oxidation by PuuD proceeds through cytochrome c-mediated electron transfer. Uric Acid 59-64 cytochrome c, somatic Homo sapiens 100-112
26251846-1 2015 URAT1 (slc22a12) was identified as the transporter responsible for renal reabsorption of the medically important compound, uric acid. Uric Acid 123-132 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 0-5
26251846-1 2015 URAT1 (slc22a12) was identified as the transporter responsible for renal reabsorption of the medically important compound, uric acid. Uric Acid 123-132 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 7-15
26251846-2 2015 However, subsequent studies have indicated that other transporters make contributions to this process, and that URAT1 transports other organic anions besides urate (including several in common with the closely related multi-specific renal organic anion transporters, OAT1 (slc22a6) and OAT3 (slc22a8)). Uric Acid 158-163 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 112-117
26006757-6 2015 RESULTS: Baseline adiponectin was 17.25(9.53-31.97) mug/mL and significantly correlated to HDL cholesterol (r=0.29, p=0.01), triglycerides (r=-0.40, p=0.0004), ferritin (r=-0.29, p=0.02), transferrin (r=-0.28, p=0.02), and uric acid (r=-0.24, p=0.04). Uric Acid 223-232 adiponectin, C1Q and collagen domain containing Homo sapiens 18-29
26251846-9 2015 Taken together with the available substrate and metabolomic data for the other OATs, our findings suggest that the transport and biochemical functions of URAT1 overlap those of OAT1 and OAT3, and could contribute to our understanding of the relationship between uric acid and the various metabolic disorders to which it has been linked. Uric Acid 262-271 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 154-159
26251846-9 2015 Taken together with the available substrate and metabolomic data for the other OATs, our findings suggest that the transport and biochemical functions of URAT1 overlap those of OAT1 and OAT3, and could contribute to our understanding of the relationship between uric acid and the various metabolic disorders to which it has been linked. Uric Acid 262-271 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 177-181
26251846-9 2015 Taken together with the available substrate and metabolomic data for the other OATs, our findings suggest that the transport and biochemical functions of URAT1 overlap those of OAT1 and OAT3, and could contribute to our understanding of the relationship between uric acid and the various metabolic disorders to which it has been linked. Uric Acid 262-271 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 186-190
26583159-7 2015 RESULTS: The adjusted odds ratio (OR) was 3.73 (95% CI: 1.18-11.75; P=0.024) for UA; 15.79 (95% CI: 3.04-81.94; P=0.001) for creatinine and 2.03 (95% CI: 0.70-5.87; P=0.192) for cystatin C in hypertensive disorders of pregnancy. Uric Acid 81-83 cystatin C Homo sapiens 178-188
26111934-0 2015 Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population. Uric Acid 56-65 fibronectin type III domain containing 5 Homo sapiens 12-18
26111934-10 2015 After adjusting for covariates, multiple linear regression analysis revealed that serum irisin level was independently and significantly associated with total cholesterol (P = 0.0005), low-density lipoprotein cholesterol (P = 0.0014), fasting fatty acids (P = 0.0402) and uric acid (P = 0.0062). Uric Acid 272-281 fibronectin type III domain containing 5 Homo sapiens 88-94
26111934-11 2015 By dividing the serum irisin levels into three tertile groups, the values of total cholesterol, low-density lipoprotein cholesterol, fasting fatty acids and uric acid were all increased significantly with the increase of irisin (P < 0.05). Uric Acid 157-166 fibronectin type III domain containing 5 Homo sapiens 22-28
26111934-11 2015 By dividing the serum irisin levels into three tertile groups, the values of total cholesterol, low-density lipoprotein cholesterol, fasting fatty acids and uric acid were all increased significantly with the increase of irisin (P < 0.05). Uric Acid 157-166 fibronectin type III domain containing 5 Homo sapiens 221-227
26111934-13 2015 Our study suggests that circulating irisin concentrations are significantly associated with lipid and uric acid metabolism in a Chinese population. Uric Acid 102-111 fibronectin type III domain containing 5 Homo sapiens 36-42
26183778-0 2015 The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice. Uric Acid 137-153 chemokine (C-X-C motif) ligand 9 Mus musculus 63-68
25763991-0 2015 Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. Uric Acid 19-28 insulin Homo sapiens 42-49
25763991-5 2015 Clearance of uric acid was inversely correlated with insulin resistance and directly correlated with fractional excretion of sodium. Uric Acid 13-22 insulin Homo sapiens 53-60
25763991-6 2015 In multivariate analysis, hypertension and hyperlipidemia, in addition to insulin resistance and fractional excretion of sodium, were associated with renal clearance of uric acid. Uric Acid 169-178 insulin Homo sapiens 74-81
25763991-8 2015 The impact of insulin resistance and renal handling of sodium on renal clearance of uric acid may help to explain why hyperuricemia is more commonly associated with diabetes and hypertension. Uric Acid 84-93 insulin Homo sapiens 14-21
26183778-8 2015 Analogously, monosodium urate crystal-induced neutrophil migration to the tibiofemural articulation, a murine model of gout, is highly reduced by intravenous injection of CXCL9(74-103). Uric Acid 13-29 chemokine (C-X-C motif) ligand 9 Mus musculus 171-176
25740202-2 2015 Considering that the independent association between the serum uric acid level and CIMT remains controversial due to the complex interrelationship with other known cardiovascular risk factors, further studies are needed. Uric Acid 63-72 CIMT Homo sapiens 83-87
25740202-3 2015 The aim of the present study is to explore the association between the serum uric acid level and CIMT in a general Chinese population and determine whether the association differs according to varied metabolic status. Uric Acid 77-86 CIMT Homo sapiens 97-101
26234731-0 2015 Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. Uric Acid 39-55 NLR family pyrin domain containing 3 Homo sapiens 103-108
25740202-8 2015 RESULTS: The serum uric acid levels were positively associated with obesity- and diabetes-related parameters and the CIMT. Uric Acid 19-28 CIMT Homo sapiens 117-121
25740202-9 2015 In a logistic regression model controlling for potential confounders, compared with the participants in the first quartile of the uric acid level, those in the fourth quartile had a higher odds of an elevated CIMT in both men (odds ratio [OR]=1.37; 95% confidence interval [CI]=1.07-1.75) and women (OR=1.48; 95% CI=1.12-1.94). Uric Acid 130-139 CIMT Homo sapiens 209-213
25740202-10 2015 The subgroup analyses revealed that an association between an elevated CIMT and the serum uric acid level persisted regardless of diuretic use and the hypertension, diabetes mellitus and chronic kidney disease status. Uric Acid 90-99 CIMT Homo sapiens 71-75
25740202-12 2015 CONCLUSIONS: The serum uric acid level is positively associated with an elevated CIMT in middle-aged and elderly Chinese subjects, independent of known risk determinants of cardiovascular disease. Uric Acid 23-32 CIMT Homo sapiens 81-85
26107422-8 2015 Most importantly, subjects who showed a fall in EPO had less proteinuria, less N-acetyl-beta-D-glucosaminidase excretion, lower serum uric acid, blood pressure, and less features of metabolic syndrome despite similar inflammation and fibrosis on biopsy as compared to the others. Uric Acid 134-143 erythropoietin Homo sapiens 48-51
26290326-10 2015 We also found significant associations of uric acid concentrations with these three SNPs (rs780094 in GCKR, corrected p = 3.94E(-5); rs1183201 in SLC17A1, corrected p = 0.005; rs505802 in SLC22A12, corrected p = 0.003) and of triglycerides with rs780094 (located in GCKR, corrected p = 2.96E(-4)). Uric Acid 42-51 glucokinase regulator Homo sapiens 102-106
26290326-10 2015 We also found significant associations of uric acid concentrations with these three SNPs (rs780094 in GCKR, corrected p = 3.94E(-5); rs1183201 in SLC17A1, corrected p = 0.005; rs505802 in SLC22A12, corrected p = 0.003) and of triglycerides with rs780094 (located in GCKR, corrected p = 2.96E(-4)). Uric Acid 42-51 solute carrier family 17 member 1 Homo sapiens 146-153
26290326-10 2015 We also found significant associations of uric acid concentrations with these three SNPs (rs780094 in GCKR, corrected p = 3.94E(-5); rs1183201 in SLC17A1, corrected p = 0.005; rs505802 in SLC22A12, corrected p = 0.003) and of triglycerides with rs780094 (located in GCKR, corrected p = 2.96E(-4)). Uric Acid 42-51 solute carrier family 22 member 12 Homo sapiens 188-196
26290326-10 2015 We also found significant associations of uric acid concentrations with these three SNPs (rs780094 in GCKR, corrected p = 3.94E(-5); rs1183201 in SLC17A1, corrected p = 0.005; rs505802 in SLC22A12, corrected p = 0.003) and of triglycerides with rs780094 (located in GCKR, corrected p = 2.96E(-4)). Uric Acid 42-51 glucokinase regulator Homo sapiens 266-270
26290326-12 2015 CONCLUSIONS: Three SUA correlated SNPs in Caucasian population, rs780094 in GCKR, rs1183201 in SLC17A1 and rs505802 in SLC22A12 were confirmed to be associated with gout arthritis and uric acid concentrations in Han Chinese males. Uric Acid 184-193 glucokinase regulator Homo sapiens 76-80
26290326-12 2015 CONCLUSIONS: Three SUA correlated SNPs in Caucasian population, rs780094 in GCKR, rs1183201 in SLC17A1 and rs505802 in SLC22A12 were confirmed to be associated with gout arthritis and uric acid concentrations in Han Chinese males. Uric Acid 184-193 solute carrier family 17 member 1 Homo sapiens 95-102
26290326-12 2015 CONCLUSIONS: Three SUA correlated SNPs in Caucasian population, rs780094 in GCKR, rs1183201 in SLC17A1 and rs505802 in SLC22A12 were confirmed to be associated with gout arthritis and uric acid concentrations in Han Chinese males. Uric Acid 184-193 solute carrier family 22 member 12 Homo sapiens 119-127
26268398-5 2015 RESULTS: Men with decreased eGFR (eGFR < 60 ml/min per 1.73 m(2)) were older, and had higher meanWC, systolic and diastolic BP, PP, MAP, total fasting glucose, LDL-C ,glyceride and uric acid levels and were current drinker/smoker at the baseline (all P < 0.05). Uric Acid 184-193 epidermal growth factor receptor Homo sapiens 28-32
26268398-5 2015 RESULTS: Men with decreased eGFR (eGFR < 60 ml/min per 1.73 m(2)) were older, and had higher meanWC, systolic and diastolic BP, PP, MAP, total fasting glucose, LDL-C ,glyceride and uric acid levels and were current drinker/smoker at the baseline (all P < 0.05). Uric Acid 184-193 epidermal growth factor receptor Homo sapiens 34-38
25714839-8 2015 Mechanistically, absence of caspase-1 is associated with increased expression of IL-33, uric acid, and spleen tyrosine kinase (Syk) production. Uric Acid 88-97 caspase 1 Mus musculus 28-37
26346636-0 2015 Significant association between parathyroid hormone and uric acid level in men. Uric Acid 56-65 parathyroid hormone Homo sapiens 32-51
26346636-1 2015 BACKGROUND: Previous reports of patients undergoing parathyroidectomy and of patients receiving teriparatide as antiosteoporotic treatment have suggested a plausible relationship between parathyroid hormone (PTH) and uric acid. Uric Acid 217-226 parathyroid hormone Homo sapiens 187-206
26550347-2 2015 The PDZK1 locus has been determined to be associated with the serum urate concentration. Uric Acid 68-73 PDZ domain containing 1 Homo sapiens 4-9
25995007-6 2015 This is exemplified by recent reports: (1) identifying XOR as a nitrite reductase and thus a source of beneficial nitric oxide (( )NO) under in vivo conditions similar to those where XOR inhibition has been assumed an optimal treatment choice, (2) describing XOR-derived uric acid (UA) as a critical pro-inflammatory mediator in vascular and metabolic disease and (3) ascribing an antioxidant/protective role for XOR-derived UA. Uric Acid 271-280 xanthine dehydrogenase Homo sapiens 55-58
25995007-6 2015 This is exemplified by recent reports: (1) identifying XOR as a nitrite reductase and thus a source of beneficial nitric oxide (( )NO) under in vivo conditions similar to those where XOR inhibition has been assumed an optimal treatment choice, (2) describing XOR-derived uric acid (UA) as a critical pro-inflammatory mediator in vascular and metabolic disease and (3) ascribing an antioxidant/protective role for XOR-derived UA. Uric Acid 282-284 xanthine dehydrogenase Homo sapiens 55-58
25995007-6 2015 This is exemplified by recent reports: (1) identifying XOR as a nitrite reductase and thus a source of beneficial nitric oxide (( )NO) under in vivo conditions similar to those where XOR inhibition has been assumed an optimal treatment choice, (2) describing XOR-derived uric acid (UA) as a critical pro-inflammatory mediator in vascular and metabolic disease and (3) ascribing an antioxidant/protective role for XOR-derived UA. Uric Acid 425-427 xanthine dehydrogenase Homo sapiens 55-58
25995007-8 2015 As such, this review will critically evaluate XOR-catalyzed oxidant, ( )NO and UA formation as well as identify factors that mediate their production, inhibition and the resultant impact on inflammatory disease. Uric Acid 79-81 xanthine dehydrogenase Homo sapiens 46-49
25355499-0 2015 High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a. Uric Acid 5-14 immunoglobulin heavy variable 4-38-2-like Homo sapiens 57-60
25355499-1 2015 BACKGROUND: High uric acid level is a known risk factor for deterioration of renal function in chronic kidney disease (CKD), but its influence on the progression of IgA nephropathy (IgAN) remains unclear. Uric Acid 17-26 IGAN1 Homo sapiens 182-186
25847066-7 2015 However, TNF-alpha levels in the diabetes + beta-anhdroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + beta-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.05). Uric Acid 85-90 tumor necrosis factor Rattus norvegicus 9-18
25934928-9 2015 Uric acid and ATP mediated a paracrine inflammatory cross-talk between damaged hepatocytes and immune cells and significantly increased the expression of LPS-inducible cytokines, IL-1beta and TNF-alpha, by immune cells. Uric Acid 0-9 interleukin 1 beta Homo sapiens 179-187
25934928-9 2015 Uric acid and ATP mediated a paracrine inflammatory cross-talk between damaged hepatocytes and immune cells and significantly increased the expression of LPS-inducible cytokines, IL-1beta and TNF-alpha, by immune cells. Uric Acid 0-9 tumor necrosis factor Homo sapiens 192-201
26276649-0 2015 Positive correlation between uric acid and C-reactive protein serum level in healthy individuals and patients with acute coronary syndromes. Uric Acid 29-38 C-reactive protein Homo sapiens 43-61
26276649-1 2015 AIM: To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals. Uric Acid 52-61 C-reactive protein Homo sapiens 71-89
26276649-1 2015 AIM: To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals. Uric Acid 52-61 C-reactive protein Homo sapiens 91-94
26276649-1 2015 AIM: To assess serum levels and correlation between uric acid (UA) and C-reactive protein (CRP) in acute coronary syndrome (ACS) and apparently healthy individuals. Uric Acid 63-65 C-reactive protein Homo sapiens 71-89
25957656-1 2015 C-type lectin domain family 12, member A (CLEC12A) is a C-type lectin-like pattern recognition receptor capable of recognizing monosodium urate crystals. Uric Acid 127-143 C-type lectin domain family 12 member A Homo sapiens 0-40
25957656-1 2015 C-type lectin domain family 12, member A (CLEC12A) is a C-type lectin-like pattern recognition receptor capable of recognizing monosodium urate crystals. Uric Acid 127-143 C-type lectin domain family 12 member A Homo sapiens 42-49
25957656-3 2015 In response to monosodium urate crystals, CLEC12A effectively inhibits granulocyte and monocyte/macrophage functions and hence acts as a negative regulator of inflammation. Uric Acid 15-31 C-type lectin domain family 12 member A Homo sapiens 42-49
25847066-7 2015 However, TNF-alpha levels in the diabetes + beta-anhdroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + beta-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.05). Uric Acid 282-287 tumor necrosis factor Rattus norvegicus 9-18
25847066-9 2015 However, MMP-3 levels the diabetes + beta-anhydroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + beta-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.01). Uric Acid 79-84 matrix metallopeptidase 3 Rattus norvegicus 9-14
25847066-9 2015 However, MMP-3 levels the diabetes + beta-anhydroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + beta-anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.01). Uric Acid 276-281 matrix metallopeptidase 3 Rattus norvegicus 9-14
25909495-0 2015 Soluble monosodium urate, but not its crystal, induces toll like receptor 4-dependent immune activation in renal mesangial cells. Uric Acid 8-24 toll like receptor 4 Homo sapiens 55-75
25801748-9 2015 Association with weight, BMI, abdominal and waist circumferences, insulin levels and insulin resistance may support uric acid role as an important cardiovascular risk factor. Uric Acid 116-125 insulin Homo sapiens 66-73
25801748-9 2015 Association with weight, BMI, abdominal and waist circumferences, insulin levels and insulin resistance may support uric acid role as an important cardiovascular risk factor. Uric Acid 116-125 insulin Homo sapiens 85-92
26208103-6 2015 Uric acid level is proven to be negatively associated with eGFR at different time point after adjustment for age, body mass index and male gender (standardized beta ranges from -0.15 to -0.30 with all P<0.001).Males with low eGFR but high level of TG were on CSA, diuretics and RAS inhibitors and experienced at least one episode of acute rejection and diabetic issue were associated with a higher mean uric acid level. Uric Acid 0-9 epidermal growth factor receptor Homo sapiens 59-63
26263997-8 2015 PGEs were characterized by square-wave voltammetry of ferricyanide, gallic acid, uric acid, dopamine, and several foodstuffs. Uric Acid 81-90 prostaglandin E synthase Homo sapiens 0-4
26382171-3 2015 BHPF pretreatment significantly (p < 0.001) inhibited the CCl4-induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner. Uric Acid 148-157 chemokine (C-C motif) ligand 4 Mus musculus 61-65
26208103-6 2015 Uric acid level is proven to be negatively associated with eGFR at different time point after adjustment for age, body mass index and male gender (standardized beta ranges from -0.15 to -0.30 with all P<0.001).Males with low eGFR but high level of TG were on CSA, diuretics and RAS inhibitors and experienced at least one episode of acute rejection and diabetic issue were associated with a higher mean uric acid level. Uric Acid 0-9 epidermal growth factor receptor Homo sapiens 228-232
26193292-7 2015 Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. Uric Acid 97-106 C-reactive protein Homo sapiens 178-181
26193292-10 2015 CONCLUSION: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. Uric Acid 109-118 C-reactive protein Homo sapiens 151-154
25395544-9 2015 Multivariate logistic regression identified TCN2 776C G polymorphism as independent predictor of Alzheimer"s type dementia together with higher concentrations of homocysteine, cholesterol and uric acid and lower concentrations of oestradiol. Uric Acid 194-203 transcobalamin 2 Homo sapiens 44-48
26179594-0 2015 Uric Acid Produces an Inflammatory Response through Activation of NF-kappaB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders. Uric Acid 0-9 nuclear factor kappa B subunit 1 Homo sapiens 66-75
26179594-2 2015 Here, we showed that a high-UA diet triggered the expression of pro-inflammatory cytokines, activated the NF-kappaB pathway, and increased gliosis in the hypothalamus. Uric Acid 28-30 nuclear factor kappa B subunit 1 Homo sapiens 106-115
26179594-3 2015 Intracerebroventricular injection of UA induced hypothalamic inflammation and reactive gliosis, whereas these effects were markedly ameliorated by the inhibition of NF-kappaB. Uric Acid 37-39 nuclear factor kappa B subunit 1 Homo sapiens 165-174
26179594-6 2015 These results suggest that UA can cause hypothalamic inflammation via NF-kappaB signaling. Uric Acid 27-29 nuclear factor kappa B subunit 1 Homo sapiens 70-79
26147675-4 2015 Our study aims to test variants in two genes abundantly expressed in the kidney, LRP2 and COMT, for their association with uric acid and gout. Uric Acid 123-132 LDL receptor related protein 2 Homo sapiens 81-85
26147675-4 2015 Our study aims to test variants in two genes abundantly expressed in the kidney, LRP2 and COMT, for their association with uric acid and gout. Uric Acid 123-132 catechol-O-methyltransferase Homo sapiens 90-94
26147675-6 2015 These LRP2 and COMT gene polymorphisms showed no significant effect on uric acid (P = 0.204 and 0.188, separately); however, rs2544390 in LRP2 did influence uric acid levels in individuals with BMI >= 25 (P = 0.009). Uric Acid 157-166 LDL receptor related protein 2 Homo sapiens 138-142
26147675-10 2015 Rs2544390 in LRP2 only influenced uric acid levels in individuals with BMI >= 25, which might explain the discrepant results among previous studies. Uric Acid 34-43 LDL receptor related protein 2 Homo sapiens 13-17
25972451-9 2015 These results suggested that mNPT3 is a polyspecific organic anion transporter that is involved in circulation of urate throughout the body. Uric Acid 114-119 solute carrier family 17 (sodium phosphate), member 2 Mus musculus 29-34
26167684-0 2015 SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration. Uric Acid 70-79 solute carrier family 2 member 9 Homo sapiens 0-6
26167684-1 2015 OBJECTIVES: SLC2A9 gene variants have been associated with urinary uric acid (UA) concentration, but little is known about the functional mechanism linking these gene variants with UA. Uric Acid 67-76 solute carrier family 2 member 9 Homo sapiens 12-18
26167684-1 2015 OBJECTIVES: SLC2A9 gene variants have been associated with urinary uric acid (UA) concentration, but little is known about the functional mechanism linking these gene variants with UA. Uric Acid 78-80 solute carrier family 2 member 9 Homo sapiens 12-18
26167684-4 2015 The SLC2A9 SNP most significantly associated with urinary UA concentration was then tested for associations with gene expression levels from uric acid absorption/secretion associated genes. Uric Acid 58-60 solute carrier family 2 member 9 Homo sapiens 4-10
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 65-67 solute carrier family 2 member 9 Homo sapiens 30-36
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 65-67 solute carrier family 2 member 9 Homo sapiens 127-133
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 65-67 solute carrier family 2 member 9 Homo sapiens 127-133
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 267-269 solute carrier family 2 member 9 Homo sapiens 30-36
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 267-269 solute carrier family 2 member 9 Homo sapiens 127-133
26167684-6 2015 RESULTS: The most significant SLC2A9 SNP associated with urinary UA (rs12509955, corrected p = 0.001) was also associated with SLC2A9 gene expression levels (corrected p = 0.0084); however, SLC2A9 gene expression levels were not significantly associated with urinary UA concentrations (p = 0.509). Uric Acid 267-269 solute carrier family 2 member 9 Homo sapiens 127-133
25999428-1 2015 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Uric Acid 65-74 xanthine dehydrogenase Mus musculus 0-16
25999428-1 2015 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Uric Acid 65-74 xanthine dehydrogenase Mus musculus 18-20
25999428-1 2015 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Uric Acid 76-78 xanthine dehydrogenase Mus musculus 0-16
25999428-1 2015 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Uric Acid 76-78 xanthine dehydrogenase Mus musculus 18-20
25824593-4 2015 Moreover, HUVEC viability and expression levels of ICAM-1 induced by monosodium urate (MSU) crystals were assessed to determine the activities of potential ingredients in MSW. Uric Acid 69-85 intercellular adhesion molecule 1 Homo sapiens 51-57
25109682-0 2015 Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. Uric Acid 0-16 NFE2 like bZIP transcription factor 2 Homo sapiens 34-38
25109682-0 2015 Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. Uric Acid 0-16 heme oxygenase 1 Homo sapiens 44-60
25109682-0 2015 Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. Uric Acid 0-16 GLI family zinc finger 2 Homo sapiens 87-92
25109682-11 2015 These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.Cellular & Molecular Immunology advance online publication, 11 August 2014; doi:10.1038/cmi.2014.65. Uric Acid 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 28-32
25109682-11 2015 These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.Cellular & Molecular Immunology advance online publication, 11 August 2014; doi:10.1038/cmi.2014.65. Uric Acid 114-117 heme oxygenase 1 Homo sapiens 37-41
25109682-11 2015 These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.Cellular & Molecular Immunology advance online publication, 11 August 2014; doi:10.1038/cmi.2014.65. Uric Acid 114-117 GLI family zinc finger 2 Homo sapiens 129-134
25109682-11 2015 These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.Cellular & Molecular Immunology advance online publication, 11 August 2014; doi:10.1038/cmi.2014.65. Uric Acid 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 272-276
25109682-11 2015 These findings suggest that Nrf2 and HO-1 mediate redox homeostasis and interact with pro-inflammatory factors in MSU-challenged THP-1 cells, thereby providing new insight into how MSU-induced gouty inflammation is mediated by specific mechanisms that are involved in the Nrf2/Ho-1 antioxidant signaling pathway.Cellular & Molecular Immunology advance online publication, 11 August 2014; doi:10.1038/cmi.2014.65. Uric Acid 114-117 heme oxygenase 1 Homo sapiens 277-281
26252258-4 2015 Moreover, SGLT2 inhibitors are able to reduce glomerular hyperfiltration, systemic and intraglomerular pressure and uric acid levels, with consequent beneficial effects on the progression of kidney disease in non diabetic patients as well. Uric Acid 116-125 solute carrier family 5 member 2 Homo sapiens 10-15
25824593-4 2015 Moreover, HUVEC viability and expression levels of ICAM-1 induced by monosodium urate (MSU) crystals were assessed to determine the activities of potential ingredients in MSW. Uric Acid 87-90 intercellular adhesion molecule 1 Homo sapiens 51-57
25922070-0 2015 Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport. Uric Acid 117-122 solute carrier family 2 member 9 Homo sapiens 79-86
25922070-2 2015 Human glucose transporter 9 (hSLC2A9) is an essential protein that mainly regulates urate/hexose homeostasis in human kidney and liver. Uric Acid 84-89 solute carrier family 2 member 9 Homo sapiens 29-36
25922070-6 2015 This current study demonstrates that the I335V mutant transports urate similarly to the wild type hSLC2A9; however, Ile-335 is necessary for urate/fructose trans-acceleration exchange to occur. Uric Acid 65-70 solute carrier family 2 member 9 Homo sapiens 98-105
25922070-6 2015 This current study demonstrates that the I335V mutant transports urate similarly to the wild type hSLC2A9; however, Ile-335 is necessary for urate/fructose trans-acceleration exchange to occur. Uric Acid 141-146 solute carrier family 2 member 9 Homo sapiens 98-105
25922070-9 2015 The hSLC2A9 model also predicted that Trp-110 is a crucial site that could directly interact with urate during transport. Uric Acid 98-103 solute carrier family 2 member 9 Homo sapiens 4-11
25922070-10 2015 Together, these studies confirm that hSLC2A9 transports both urate and fructose, but it interacts with them in different ways. Uric Acid 61-66 solute carrier family 2 member 9 Homo sapiens 37-44
25922070-11 2015 Therefore, this study advances our understanding of how hSLC2A9 mediates urate and fructose transport, providing further information for developing pharmacological agents to treat hyperuricemia and related diseases, such as gout, hypertension, and diabetes. Uric Acid 73-78 solute carrier family 2 member 9 Homo sapiens 56-63
26053021-0 2015 Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia. Uric Acid 15-24 NLR family pyrin domain containing 3 Homo sapiens 47-52
26053021-10 2015 The cytokine determination showed that monocytes from women with PE produced higher endogenous levels of IL-1beta, IL-18 and TNF-alpha compared to the other groups, while the stimulus with MSU led to higher production of these cytokines in preeclamptic group than in the NT group. Uric Acid 189-192 interleukin 18 Homo sapiens 115-120
26053021-10 2015 The cytokine determination showed that monocytes from women with PE produced higher endogenous levels of IL-1beta, IL-18 and TNF-alpha compared to the other groups, while the stimulus with MSU led to higher production of these cytokines in preeclamptic group than in the NT group. Uric Acid 189-192 tumor necrosis factor Homo sapiens 125-134
26053021-12 2015 These cells stimulation with MSU demonstrates that uric acid plays a role in NLRP3 inflammasome activation, suggesting the participation of this inflammatory complex in the pathogenesis of preeclampsia. Uric Acid 51-60 NLR family pyrin domain containing 3 Homo sapiens 77-82
25502344-4 2015 A weighted genetic urate score was calculated using the SLC2A9, ABCG2, SLC17A1, SLC22A11, and SLC22A12 single-nucleotide polymorphisms (SNPs) that explains 3.4% of the variance in serum urate. Uric Acid 19-24 solute carrier family 2 member 9 Homo sapiens 56-62
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 0-28 NLR family, pyrin domain containing 3 Mus musculus 73-78
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 0-28 interleukin 1 beta Mus musculus 104-121
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 0-28 interleukin 1 beta Mus musculus 123-131
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 30-33 NLR family, pyrin domain containing 3 Mus musculus 73-78
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 30-33 interleukin 1 beta Mus musculus 104-121
25914377-2 2015 Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment. Uric Acid 30-33 interleukin 1 beta Mus musculus 123-131
25600084-4 2015 Uric acid (UA) recently emerged as an inflammatory factor that increases oxidative stress and promotes activation of the renin angiotensin aldosterone system. Uric Acid 0-9 renin Homo sapiens 121-126
25600084-4 2015 Uric acid (UA) recently emerged as an inflammatory factor that increases oxidative stress and promotes activation of the renin angiotensin aldosterone system. Uric Acid 11-13 renin Homo sapiens 121-126
25605806-9 2015 These studies suggest that DPP-4 inhibition ameliorates hepatic steatosis and insulin resistance by suppressing hepatic TAG and DAG accumulation through enhanced mitochondrial carbohydrate utilization and hepatic TAG secretion/export with a concomitant reduction of uric acid production. Uric Acid 266-275 dipeptidylpeptidase 4 Mus musculus 27-32
25502344-4 2015 A weighted genetic urate score was calculated using the SLC2A9, ABCG2, SLC17A1, SLC22A11, and SLC22A12 single-nucleotide polymorphisms (SNPs) that explains 3.4% of the variance in serum urate. Uric Acid 19-24 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 64-69
25502344-4 2015 A weighted genetic urate score was calculated using the SLC2A9, ABCG2, SLC17A1, SLC22A11, and SLC22A12 single-nucleotide polymorphisms (SNPs) that explains 3.4% of the variance in serum urate. Uric Acid 19-24 solute carrier family 17 member 1 Homo sapiens 71-78
25502344-4 2015 A weighted genetic urate score was calculated using the SLC2A9, ABCG2, SLC17A1, SLC22A11, and SLC22A12 single-nucleotide polymorphisms (SNPs) that explains 3.4% of the variance in serum urate. Uric Acid 19-24 solute carrier family 22 member 11 Homo sapiens 80-88
25502344-4 2015 A weighted genetic urate score was calculated using the SLC2A9, ABCG2, SLC17A1, SLC22A11, and SLC22A12 single-nucleotide polymorphisms (SNPs) that explains 3.4% of the variance in serum urate. Uric Acid 19-24 solute carrier family 22 member 12 Homo sapiens 94-102
25773064-0 2015 Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy. Uric Acid 0-9 NUMB, endocytic adaptor protein Rattus norvegicus 32-36
25773064-0 2015 Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy. Uric Acid 75-84 NUMB, endocytic adaptor protein Rattus norvegicus 32-36
25773064-8 2015 These findings indicated that uric acid crystal could increase URAT1 membrane distribution through inhibiting Numb-induced URAT1 lysosome degradation. Uric Acid 30-39 NUMB, endocytic adaptor protein Rattus norvegicus 110-114
26029914-8 2015 Uric acid was positively correlated with albuminuria and creatinine levels (p < 0.0001) but negatively correlated with eGFR (p < 0.0001) after adjusting for confounding factors. Uric Acid 0-9 epidermal growth factor receptor Homo sapiens 122-126
25840998-10 2015 Endostatin levels were correlated with pulmonary arterial wedge pressure, and established prognostic markers of IPAH, right atrial pressure, cardiac index, 6-min walking distance, NH2-terminal pro-brain natriuretic peptide, and uric acid. Uric Acid 228-237 collagen type XVIII alpha 1 chain Homo sapiens 0-10
25651569-2 2015 We investigated the role of soluble uric acid in NLRP3 inflammasome activation in macrophages to demonstrate the effect of systemic hyperuricemia on progressive kidney damage in type 2 diabetes. Uric Acid 36-45 NLR family pyrin domain containing 3 Homo sapiens 49-54
25756085-3 2015 The as-developed sensor can selectively detect AA, DA, and UA with a good anti-interference ability, wide concentration ranges of 1.0 muM-2.1 mM, 0.4-96.0 muM, and 1.0-150.0 muM, respectively, together with low detection limits of 0.057, 0.048, and 0.081 muM (S/N = 3), respectively. Uric Acid 59-61 latexin Homo sapiens 134-137
25756085-3 2015 The as-developed sensor can selectively detect AA, DA, and UA with a good anti-interference ability, wide concentration ranges of 1.0 muM-2.1 mM, 0.4-96.0 muM, and 1.0-150.0 muM, respectively, together with low detection limits of 0.057, 0.048, and 0.081 muM (S/N = 3), respectively. Uric Acid 59-61 latexin Homo sapiens 155-158
25756085-3 2015 The as-developed sensor can selectively detect AA, DA, and UA with a good anti-interference ability, wide concentration ranges of 1.0 muM-2.1 mM, 0.4-96.0 muM, and 1.0-150.0 muM, respectively, together with low detection limits of 0.057, 0.048, and 0.081 muM (S/N = 3), respectively. Uric Acid 59-61 latexin Homo sapiens 155-158
25756085-3 2015 The as-developed sensor can selectively detect AA, DA, and UA with a good anti-interference ability, wide concentration ranges of 1.0 muM-2.1 mM, 0.4-96.0 muM, and 1.0-150.0 muM, respectively, together with low detection limits of 0.057, 0.048, and 0.081 muM (S/N = 3), respectively. Uric Acid 59-61 latexin Homo sapiens 155-158
25756085-4 2015 For simultaneous detection of AA, DA, and UA, the linear current-concentration responses were observed from 1.0 muM-4.1 mM, 0.05-112.0 muM, and 3.0-186.0 muM, with the detection limits of 0.185, 0.017, and 0.654 muM (S/N = 3), respectively. Uric Acid 42-44 latexin Homo sapiens 112-115
25756085-4 2015 For simultaneous detection of AA, DA, and UA, the linear current-concentration responses were observed from 1.0 muM-4.1 mM, 0.05-112.0 muM, and 3.0-186.0 muM, with the detection limits of 0.185, 0.017, and 0.654 muM (S/N = 3), respectively. Uric Acid 42-44 latexin Homo sapiens 135-138
25756085-4 2015 For simultaneous detection of AA, DA, and UA, the linear current-concentration responses were observed from 1.0 muM-4.1 mM, 0.05-112.0 muM, and 3.0-186.0 muM, with the detection limits of 0.185, 0.017, and 0.654 muM (S/N = 3), respectively. Uric Acid 42-44 latexin Homo sapiens 135-138
25756085-4 2015 For simultaneous detection of AA, DA, and UA, the linear current-concentration responses were observed from 1.0 muM-4.1 mM, 0.05-112.0 muM, and 3.0-186.0 muM, with the detection limits of 0.185, 0.017, and 0.654 muM (S/N = 3), respectively. Uric Acid 42-44 latexin Homo sapiens 135-138
25756085-2 2015 The as-prepared nanocomposite modified glassy carbon electrode (PdAg NFs/rGO/GCE) showed enhanced catalytic currents and enlarged peak potential separations for the oxidation of ascorbic acid (AA), dopamine (DA), and uric acid (UA) as compared to those of PdAg/GCE, rGO/GCE, commercial Pd/C/GCE, and bare GCE. Uric Acid 217-226 glycine decarboxylase Homo sapiens 77-80
25756085-2 2015 The as-prepared nanocomposite modified glassy carbon electrode (PdAg NFs/rGO/GCE) showed enhanced catalytic currents and enlarged peak potential separations for the oxidation of ascorbic acid (AA), dopamine (DA), and uric acid (UA) as compared to those of PdAg/GCE, rGO/GCE, commercial Pd/C/GCE, and bare GCE. Uric Acid 228-230 glycine decarboxylase Homo sapiens 77-80
25651569-5 2015 Soluble uric acid stimulated NLRP3 inflammasomes to produce IL-1beta in macrophages. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 29-34
25651569-5 2015 Soluble uric acid stimulated NLRP3 inflammasomes to produce IL-1beta in macrophages. Uric Acid 8-17 interleukin 1 beta Homo sapiens 60-68
25651569-6 2015 Uric acid-induced MitoSOX mediates NLRP3 activation and IL-1beta secretion. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 35-40
25651569-6 2015 Uric acid-induced MitoSOX mediates NLRP3 activation and IL-1beta secretion. Uric Acid 0-9 interleukin 1 beta Homo sapiens 56-64
25651569-9 2015 Lowering the serum uric acid level resulted in improving the albuminuria, tubular injury, macrophage infiltration, and renal IL-1beta (60% of HFD-fed OLETF) independently of glycemic control. Uric Acid 19-28 interleukin 1 beta Homo sapiens 125-133
25651569-10 2015 Direct activation of proximal tubular cells by uric acid resulted in (C-X-C motif) ligand 12 and high mobility group box-1 release and accelerated macrophage recruitment and the M1 phenotype. Uric Acid 47-56 high mobility group box 1 Homo sapiens 97-122
25813103-0 2015 Soluble uric acid increases NALP3 inflammasome and interleukin-1beta expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 28-33
25879284-6 2015 The NLRP3 inflammasome is especially relevant to aging as it can get activated in response to structurally diverse damage-associated molecular patterns (DAMPs) such as extracellular ATP, excess glucose, ceramides, amyloids, urate, and cholesterol crystals, all of which increase with age. Uric Acid 224-229 NLR family pyrin domain containing 3 Homo sapiens 4-9
25813103-0 2015 Soluble uric acid increases NALP3 inflammasome and interleukin-1beta expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway. Uric Acid 8-17 interleukin 1 beta Homo sapiens 51-68
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 toll like receptor 4 Homo sapiens 48-68
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 toll like receptor 4 Homo sapiens 70-74
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 120-167
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 169-174
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 243-248
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 254-263
25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 caspase 1 Homo sapiens 279-288
25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 toll like receptor 4 Homo sapiens 34-38
25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 NLR family pyrin domain containing 3 Homo sapiens 40-45
25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 caspase 1 Homo sapiens 47-56
25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 interleukin 1 beta Homo sapiens 58-66
25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 intercellular adhesion molecule 1 Homo sapiens 71-77
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 toll like receptor 4 Homo sapiens 4-8
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 toll like receptor 4 Homo sapiens 86-90
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 NLR family pyrin domain containing 3 Homo sapiens 92-97
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 caspase 1 Homo sapiens 99-108
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 interleukin 1 beta Homo sapiens 110-118
25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 intercellular adhesion molecule 1 Homo sapiens 123-129
25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 NLR family pyrin domain containing 3 Homo sapiens 47-52
25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 caspase 1 Homo sapiens 65-74
25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 interleukin 1 beta Homo sapiens 87-95
25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 intercellular adhesion molecule 1 Homo sapiens 100-106
25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 toll like receptor 4 Homo sapiens 165-169
25565311-3 2015 We previously established a mouse model of hyperuricemia by liver-specific deletion of Glut9, a urate transporter that provides urate to the hepatocyte enzyme uricase. Uric Acid 96-101 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 87-92
25475742-4 2015 By using cGKII gene knockdown method, we detected macrophage M1/M2 polarization, phagocytosis, and their responses to stimulation by monosodium urate (MSU). Uric Acid 133-149 protein kinase cGMP-dependent 2 Homo sapiens 9-14
25475742-4 2015 By using cGKII gene knockdown method, we detected macrophage M1/M2 polarization, phagocytosis, and their responses to stimulation by monosodium urate (MSU). Uric Acid 151-154 protein kinase cGMP-dependent 2 Homo sapiens 9-14
25475742-13 2015 Monosodium urate treatments increase cGKII expression and related function. Uric Acid 0-16 protein kinase cGMP-dependent 2 Homo sapiens 37-42
25997037-7 2015 Higher UA concentrations were associated with higher SBP levels only in overweight/obese women (beta = 3.878; 95% CI: 0.687-7.068), whereas higher CRP concentrations (>=2.6 mg/L) were associated with higher DBP in under/normal weight women (beta =2.252; 95% CI: 0.267-4.236).ALP, ALT, and Cr concentrations were positively associated with BP levels, whereas ALP was associated with a lower rate of change in BP. Uric Acid 7-9 selenium binding protein 1 Homo sapiens 53-56
25817625-0 2015 Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator. Uric Acid 6-15 chromosome 20 open reading frame 181 Homo sapiens 119-147
25817625-1 2015 BACKGROUND: Exogenous uric acid (UA) is a neuroprotective antioxidant that reinforces the benefits of intravenous recombinant tissue plasminogen activator thrombolysis in animal thromboembolic stroke. Uric Acid 22-31 chromosome 20 open reading frame 181 Homo sapiens 126-154
25817625-1 2015 BACKGROUND: Exogenous uric acid (UA) is a neuroprotective antioxidant that reinforces the benefits of intravenous recombinant tissue plasminogen activator thrombolysis in animal thromboembolic stroke. Uric Acid 33-35 chromosome 20 open reading frame 181 Homo sapiens 126-154
25787292-0 2015 High Concentrations of Uric Acid Inhibit Endothelial Cell Migration via miR-663 Which Regulates Phosphatase and Tensin Homolog by Targeting Transforming Growth Factor-beta1. Uric Acid 23-32 microRNA 663a Homo sapiens 72-79
25787292-0 2015 High Concentrations of Uric Acid Inhibit Endothelial Cell Migration via miR-663 Which Regulates Phosphatase and Tensin Homolog by Targeting Transforming Growth Factor-beta1. Uric Acid 23-32 transforming growth factor beta 1 Homo sapiens 140-172
25997037-7 2015 Higher UA concentrations were associated with higher SBP levels only in overweight/obese women (beta = 3.878; 95% CI: 0.687-7.068), whereas higher CRP concentrations (>=2.6 mg/L) were associated with higher DBP in under/normal weight women (beta =2.252; 95% CI: 0.267-4.236).ALP, ALT, and Cr concentrations were positively associated with BP levels, whereas ALP was associated with a lower rate of change in BP. Uric Acid 7-9 D-box binding PAR bZIP transcription factor Homo sapiens 210-213
25997037-7 2015 Higher UA concentrations were associated with higher SBP levels only in overweight/obese women (beta = 3.878; 95% CI: 0.687-7.068), whereas higher CRP concentrations (>=2.6 mg/L) were associated with higher DBP in under/normal weight women (beta =2.252; 95% CI: 0.267-4.236).ALP, ALT, and Cr concentrations were positively associated with BP levels, whereas ALP was associated with a lower rate of change in BP. Uric Acid 7-9 alkaline phosphatase, placental Homo sapiens 278-281
25997037-7 2015 Higher UA concentrations were associated with higher SBP levels only in overweight/obese women (beta = 3.878; 95% CI: 0.687-7.068), whereas higher CRP concentrations (>=2.6 mg/L) were associated with higher DBP in under/normal weight women (beta =2.252; 95% CI: 0.267-4.236).ALP, ALT, and Cr concentrations were positively associated with BP levels, whereas ALP was associated with a lower rate of change in BP. Uric Acid 7-9 alkaline phosphatase, placental Homo sapiens 361-364
25897296-1 2015 BACKGROUND: To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1beta in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism. Uric Acid 53-56 interleukin 1 beta Homo sapiens 74-96
25463642-6 2015 Furthermore, the GOx/NPG/GCE bioelectrode presented strong anti-interference capability against cholesterol, urea, tributyrin, ascorbic acid, and uric acid, along with a long shelf-life. Uric Acid 146-155 hydroxyacid oxidase 1 Homo sapiens 17-20
25889045-6 2015 Recent studies show that SLC2A9 is involved in renal and gut excretion of uric acid and is implicated in antioxidant defense. Uric Acid 74-83 solute carrier family 2 member 9 Homo sapiens 25-31
25897296-6 2015 Simultaneously, intercellular pro-IL-1beta was detected at 6 h. Furthermore, MSU crystals also induced NLRP3 mRNA and protein expression at 6 h to 48 h after MSU treatment. Uric Acid 77-80 interleukin 1 beta Homo sapiens 30-42
25889045-9 2015 ABCG2 is involved primarily in extra-renal uric acid under-excretion with the etiological variant influencing expression. Uric Acid 43-52 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
25897296-6 2015 Simultaneously, intercellular pro-IL-1beta was detected at 6 h. Furthermore, MSU crystals also induced NLRP3 mRNA and protein expression at 6 h to 48 h after MSU treatment. Uric Acid 77-80 NLR family pyrin domain containing 3 Homo sapiens 103-108
25897296-0 2015 Role of the NLRP3 inflammasome in the transient release of IL-1beta induced by monosodium urate crystals in human fibroblast-like synoviocytes. Uric Acid 79-95 NLR family pyrin domain containing 3 Homo sapiens 12-17
24858040-5 2015 Here, we reported a first beneficial link between p53 and uric acid. Uric Acid 58-67 tumor protein p53 Homo sapiens 50-53
25897296-0 2015 Role of the NLRP3 inflammasome in the transient release of IL-1beta induced by monosodium urate crystals in human fibroblast-like synoviocytes. Uric Acid 79-95 interleukin 1 beta Homo sapiens 59-67
25897296-1 2015 BACKGROUND: To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1beta in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism. Uric Acid 35-51 interleukin 1 beta Homo sapiens 74-96
25890021-2 2015 This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. Uric Acid 82-91 apolipoprotein E Homo sapiens 40-44
25890021-8 2015 Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. Uric Acid 129-138 apolipoprotein E Homo sapiens 23-27
25890021-8 2015 Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. Uric Acid 129-138 apolipoprotein E Homo sapiens 162-167
25890021-8 2015 Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. Uric Acid 129-138 apolipoprotein E Homo sapiens 162-166
25890021-8 2015 Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. Uric Acid 209-218 apolipoprotein E Homo sapiens 23-27
24858040-7 2015 Oxidative stress induced SLC2A9 expression in a p53-dependent manner, and inhibition of SLC2A9 by small interfering RNA (siRNA) or anti-gout drugs such as probenecid significantly increased ROS levels in an uric acid-dependent manner and greatly sensitized cancer cells to chemotherapeutic drugs. Uric Acid 207-216 solute carrier family 2 member 9 Homo sapiens 88-94
24858040-6 2015 We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive oxygen species (ROS) through transporting uric acid as a source of antioxidant. Uric Acid 18-27 solute carrier family 2 member 9 Homo sapiens 40-46
24858040-11 2015 Our findings suggest that the p53-SLC2A9 pathway is a novel antioxidant mechanism that uses uric acid to maintain ROS homeostasis and prevent accumulation of ROS-associated damage that potentially contributes to cancer development. Uric Acid 92-101 tumor protein p53 Homo sapiens 30-33
24858040-11 2015 Our findings suggest that the p53-SLC2A9 pathway is a novel antioxidant mechanism that uses uric acid to maintain ROS homeostasis and prevent accumulation of ROS-associated damage that potentially contributes to cancer development. Uric Acid 92-101 solute carrier family 2 member 9 Homo sapiens 34-40
25890021-9 2015 In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p<0.05). Uric Acid 60-69 apolipoprotein E Homo sapiens 35-40
24858040-6 2015 We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive oxygen species (ROS) through transporting uric acid as a source of antioxidant. Uric Acid 18-27 solute carrier family 2 member 9 Homo sapiens 62-67
24858040-6 2015 We identified the uric acid transporter SLC2A9 (also known as GLUT9) as a direct p53 target gene and a key downstream effector in the reduction of reactive oxygen species (ROS) through transporting uric acid as a source of antioxidant. Uric Acid 18-27 tumor protein p53 Homo sapiens 81-84
25761742-3 2015 We aimed to investigate the impact of baseline serum uric acid levels on progression of IgAN. Uric Acid 53-62 IGAN1 Homo sapiens 88-92
25833971-2 2015 Genetic studies in adults have consistently identified associations of solute carrier family 2, member 9 (SLC2A9), polymorphisms with variation in serum uric acid. Uric Acid 153-162 solute carrier family 2 member 9 Homo sapiens 71-104
25833971-2 2015 Genetic studies in adults have consistently identified associations of solute carrier family 2, member 9 (SLC2A9), polymorphisms with variation in serum uric acid. Uric Acid 153-162 solute carrier family 2 member 9 Homo sapiens 106-112
25833971-3 2015 However, it is not known whether the association of serum uric acid with SLC2A9 polymorphisms manifests in children. Uric Acid 58-67 solute carrier family 2 member 9 Homo sapiens 73-79
25833971-6 2015 RESULTS: We found serum uric acid to be significantly heritable [h(2) +- SD = 0.45 +- 0.08, P = 5.8 x 10(-11)] and associated with SLC2A9 variants (P values between 10(-16) and 10(-7)). Uric Acid 24-33 solute carrier family 2 member 9 Homo sapiens 131-137
25833971-8 2015 We also found positive genetic correlations between serum uric acid and BMI z score (rhoG = 0.45, P = 0.002), percentage of body fat (rhoG = 0.28, P = 0.04), fat mass (rhoG = 0.34, P = 0.02), waist circumference (rhoG = 0.42, P = 0.003), and waist-to-height ratio (rhoG = 0.46, P = 0.001). Uric Acid 58-67 ras homolog family member G Homo sapiens 85-89
25833971-10 2015 As in adults, genetic variation in SLC2A9 is associated with serum uric acid concentrations, an important biomarker of renal and cardiovascular disease risk, in Hispanic children. Uric Acid 67-76 solute carrier family 2 member 9 Homo sapiens 35-41
25150977-6 2015 Methods are illustrated in an applied example considering causal relationships between body mass index, C-reactive protein and uric acid. Uric Acid 127-136 C-reactive protein Homo sapiens 104-122
25461755-1 2015 A new uric acid biosensor was constructed using ferrocene (Fc) induced electro-activated uricase (UOx) deposited within Nafion (Naf) on glassy carbon electrode (GCE). Uric Acid 6-15 urate oxidase (pseudogene) Homo sapiens 98-101
25461755-1 2015 A new uric acid biosensor was constructed using ferrocene (Fc) induced electro-activated uricase (UOx) deposited within Nafion (Naf) on glassy carbon electrode (GCE). Uric Acid 6-15 aminomethyltransferase Homo sapiens 161-164
25461755-6 2015 Cyclic voltammetry, differential pulse voltammetry and amperometry all demonstrated the excellent response of the Naf/UOx/Fc/GCE biosensor to uric acid. Uric Acid 142-151 urate oxidase (pseudogene) Homo sapiens 118-121
25461755-6 2015 Cyclic voltammetry, differential pulse voltammetry and amperometry all demonstrated the excellent response of the Naf/UOx/Fc/GCE biosensor to uric acid. Uric Acid 142-151 aminomethyltransferase Homo sapiens 122-128
25761742-13 2015 CONCLUSION: Baseline serum uric acid concentration is directly proportional to the rate of decline in renal functions in patients with IgAN. Uric Acid 27-36 IGAN1 Homo sapiens 135-139
25761742-14 2015 Uric acid-lowering treatments may be beneficial for the prevention of progression of IgAN. Uric Acid 0-9 IGAN1 Homo sapiens 85-89
25800347-2 2015 We present evidence that macrophage secretion of IL1beta upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS. Uric Acid 249-258 interleukin 1 beta Homo sapiens 49-56
25455681-0 2015 The effect of initiating pharmacologic insulin on serum uric acid levels in patients with diabetes: a matched cohort analysis. Uric Acid 56-65 insulin Homo sapiens 39-46
25455681-3 2015 Rising serum insulin levels correlate with an increase in serum uric acid (UA). Uric Acid 64-73 insulin Homo sapiens 13-20
25455681-3 2015 Rising serum insulin levels correlate with an increase in serum uric acid (UA). Uric Acid 75-77 insulin Homo sapiens 13-20
25455681-4 2015 The current study evaluated the effect of pharmacologic insulin on serum UA levels in patients with diabetes. Uric Acid 73-75 insulin Homo sapiens 56-63
25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 31-33 insulin Homo sapiens 100-107
25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 51-53 insulin Homo sapiens 100-107
25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 51-53 insulin Homo sapiens 100-107
25455681-12 2015 CONCLUSIONS: Initiation of insulin among patients with diabetes was associated with a statistically significant increase in serum UA levels. Uric Acid 130-132 insulin Homo sapiens 27-34
25800347-2 2015 We present evidence that macrophage secretion of IL1beta upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS. Uric Acid 249-258 xanthine dehydrogenase Homo sapiens 195-217
25889736-2 2015 In this study, the involvement of TG2 in monosodium urate (MSU) crystal-induced inflammation was studied. Uric Acid 41-57 transglutaminase 2, C polypeptide Mus musculus 34-37
25889736-2 2015 In this study, the involvement of TG2 in monosodium urate (MSU) crystal-induced inflammation was studied. Uric Acid 59-62 transglutaminase 2, C polypeptide Mus musculus 34-37
25681332-8 2015 In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release. Uric Acid 44-60 NLR family, pyrin domain containing 3 Mus musculus 82-87
25775471-9 2015 In the multivariate analysis, cardiovascular involvement in CTD patients was associated with age, systolic pressure, body mass index, uric acid, disease duration > 2 years, use of moderate- to high-dose glucocorticoids, and ILD with a high alveolar inflammation score. Uric Acid 134-143 CTD Homo sapiens 60-63
25576954-6 2015 The lowest detection limits (signal/noise=3) were 25.0, 0.04, and 0.2 muM for AA, DA, and UA, respectively. Uric Acid 90-92 latexin Homo sapiens 70-73
25681332-8 2015 In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release. Uric Acid 44-60 interleukin 1 beta Mus musculus 165-173
25761061-6 2015 We also demonstrated that NLRP3 could activate NF-kappaB and induce cytokines in response to sterile signals, monosodium urate crystals and aluminum adjuvant. Uric Acid 110-126 NLR family pyrin domain containing 3 Homo sapiens 26-31
25976047-2 2015 METHODS: Blood samples from hospitalized patients with AMs (n = 69) in acute phase and other neurological disorders (n = 50) between September 2009 and December 2013 and healthy subjects (n = 50) were used to detect UA level by enzymatic calorimetric method.Expanded disability status scale (EDSS) and spinal MRI-T2 imaging were used for clinical and imaging severity evaluations.And serum AQP4 anitbody and other antibodies were tested. Uric Acid 216-218 aquaporin 4 Homo sapiens 390-394
26113950-12 2015 This study also reports a significant association between CRP and systolic blood pressure, diastolic blood pressure, uric acid AST and ALP (p. CONCLUSION: The inflammatory cytokines, IL6, TNF alpha and CRP are elevated in severe preeclampsia and may mediate some of the clinical manifestations of the disorder. Uric Acid 117-126 C-reactive protein Homo sapiens 58-61
25567367-4 2015 Results from assessment of the routine laboratory variables showed an unexpected statistically significant and clinically relevant decrease in blood uric acid with the increase in ABT-639 dose, which is possibly due to inhibition in URAT1 transporter. Uric Acid 149-158 solute carrier family 22 member 12 Homo sapiens 233-238
25603039-4 2015 The rest of the medications in the pipeline for hyperuricemia are targeting renal transporters of uric acid, mainly URAT1 and OAT4, acting as uricosuric agents. Uric Acid 98-107 solute carrier family 22 member 12 Homo sapiens 116-121
25603039-4 2015 The rest of the medications in the pipeline for hyperuricemia are targeting renal transporters of uric acid, mainly URAT1 and OAT4, acting as uricosuric agents. Uric Acid 98-107 solute carrier family 22 member 9 Homo sapiens 126-130
25686106-4 2015 We report that BHB, but neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids. Uric Acid 175-180 NLR family pyrin domain containing 3 Homo sapiens 141-146
25345339-18 2015 Cross-correlation analysis in the periodontitis disease group showed a significant association of plasma AST, salivary AST, and salivary ALT with uric acid level. Uric Acid 146-155 solute carrier family 17 member 5 Homo sapiens 105-108
25345339-18 2015 Cross-correlation analysis in the periodontitis disease group showed a significant association of plasma AST, salivary AST, and salivary ALT with uric acid level. Uric Acid 146-155 solute carrier family 17 member 5 Homo sapiens 119-122
25760382-7 2015 The results demonstrated that rhein significantly decreased the serum uric acid level by inhibiting the xanthine oxidase activity and increasing the excretion of urinary uric acid. Uric Acid 70-79 xanthine dehydrogenase Mus musculus 104-120
25618698-1 2015 In this study, a new uric acid biosensor was constructed based on ferrocene containing polymer poly(vinylferrocene) (PVF), carboxylated multiwalled carbon nanotubes (c-MWCNT) and gelatin (GEL) modified glassy carbon electrode (GCE). Uric Acid 21-30 glycine decarboxylase Homo sapiens 227-230
25394527-6 2015 RESULTS: In our study, we showed an increase of NT-proBNP and the serum cTnT, of serum uric acid and homocysteine with a positive correlation with the increase of cIMT and LVMI and reduced baFMD compared with the controls. Uric Acid 87-96 troponin T2, cardiac type Homo sapiens 72-76
25288358-6 2015 CONCLUSIONS: We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. Uric Acid 117-119 solute carrier family 6 member 3 Homo sapiens 85-88
25535087-10 2015 The mRNA expression level of URAT1 was positively correlated with the concentration of uric acid but, negatively correlated with the expression level of miR-34a. Uric Acid 87-96 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 29-34
25535087-11 2015 CONCLUSIONS: The ability of XZCBF to facilitate the excretion of uric acid and to lower its level in the model group was mediated by the upregulation of miR-34a and the inhibition of URAT1 mRNA expression, which suggests that XZCBF could be an option for the treatment of hyperuricemia in mice. Uric Acid 65-74 microRNA 34a Mus musculus 153-160
25545230-1 2015 BACKGROUND: Although both serum gamma-glutamyltransferase (GGT) and uric acid are correlated with hypertension, studies on the association between serum GGT and uric acid in normotensive individuals are rare. Uric Acid 161-170 gamma-glutamyltransferase light chain family member 3 Homo sapiens 153-156
25545230-7 2015 RESULTS: Uric acid was increased in parallel with increasing serum GGT (P<0.001). Uric Acid 9-18 gamma-glutamyltransferase light chain family member 3 Homo sapiens 67-70
25545230-8 2015 After correction for age, sex, smoking and alcohol consumption, serum GGT was positively associated with uric acid (r=0.42, P<0.001), SBP (r=0.22, P<0.001), and DBP (r=0.19, P<0.001). Uric Acid 105-114 gamma-glutamyltransferase light chain family member 3 Homo sapiens 70-73
25545230-9 2015 When compared with lowest GGT tertile, the odds ratio of the middle tertile for the increased serum uric acid was 3.43 (95% CI, 1.39-8.47) and 7.29 (95% CI, 1.57-33.82) for the highest tertile after adjustment for age, sex, BMI, smoking, alcohol consumption, SBP, DBP, creatinine and HOMA-IR. Uric Acid 100-109 gamma-glutamyltransferase light chain family member 3 Homo sapiens 26-29
25545230-10 2015 CONCLUSIONS: Serum GGT is strongly associated with the increased uric acid concentrations in normotensive Chinese adults. Uric Acid 65-74 gamma-glutamyltransferase light chain family member 3 Homo sapiens 19-22
25634685-12 2015 Xanthine dehydrogenase (XDH), which plays an important role in uric acid synthesis, was up-regulated by the high-fat diet (p < 0.05). Uric Acid 63-72 xanthine dehydrogenase Homo sapiens 0-22
25634685-12 2015 Xanthine dehydrogenase (XDH), which plays an important role in uric acid synthesis, was up-regulated by the high-fat diet (p < 0.05). Uric Acid 63-72 xanthine dehydrogenase Homo sapiens 24-27
25658588-10 2015 Both low and high serum uric acid levels were associated with the outcome and eGFR decline in males (multivariate logistic additional additive models, linear p = 0.0001, spline p = 0.043; generalized additive models, linear p = 0.0001, spline p = 0.012). Uric Acid 24-33 epidermal growth factor receptor Homo sapiens 78-82
25658588-11 2015 In subjects with low serum uric acid levels (male, <5 mg/dl; female, <3.6 mg/dl), multivariate linear mixed models showed that low serum uric acid levels were associated with eGFR decline in a time-dependent manner (male, p = 0.0001; female, p = 0.045). Uric Acid 143-152 epidermal growth factor receptor Homo sapiens 181-185
25288358-0 2015 Uric acid relates to dopamine transporter availability in Parkinson"s disease. Uric Acid 0-9 solute carrier family 6 member 3 Homo sapiens 21-41
25769564-3 2015 However, the association between uric acid (UA), RAS, and TGF-beta1 in allograft recipients has not been demonstrated. Uric Acid 33-42 transforming growth factor beta 1 Homo sapiens 58-67
25769564-10 2015 We found that increased urine TGF-beta1 was correlated with rising serum UA levels and a decrease of the eGFR (r = 0.27 [P = .01]; r = -0.38 [P = .0003]). Uric Acid 73-75 transforming growth factor beta 1 Homo sapiens 30-39
25717318-9 2014 A Salmonella TLP knock-out strain demonstrated that TLP was essential for the bacteria"s survival in the high uric acid environment of the chicken alimentary tract. Uric Acid 110-119 TATA-box binding protein like 1 Gallus gallus 13-16
25717318-9 2014 A Salmonella TLP knock-out strain demonstrated that TLP was essential for the bacteria"s survival in the high uric acid environment of the chicken alimentary tract. Uric Acid 110-119 TATA-box binding protein like 1 Gallus gallus 52-55
25658427-6 2015 Further, HC-030031 treated and TRPA1 deficient mice developed tempered inflammatory edema when MSU crystals were injected into the paw. Uric Acid 95-98 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 31-36
26168668-1 2015 OBJECTIVE: To confirm the possible relationships between serum level of uric acid (UA) and benign paroxysmal positional vertigo (BPPV). Uric Acid 72-81 benign paroxysmal positional vertigo Homo sapiens 129-133
26168668-1 2015 OBJECTIVE: To confirm the possible relationships between serum level of uric acid (UA) and benign paroxysmal positional vertigo (BPPV). Uric Acid 83-85 benign paroxysmal positional vertigo Homo sapiens 129-133
25301104-2 2015 The urate transporter GLUT9 (encoded by the SLC2A9 gene) is a major genetic determinant of serum uric acid level in humans. Uric Acid 97-106 solute carrier family 2 member 9 Homo sapiens 22-27
25301104-2 2015 The urate transporter GLUT9 (encoded by the SLC2A9 gene) is a major genetic determinant of serum uric acid level in humans. Uric Acid 97-106 solute carrier family 2 member 9 Homo sapiens 44-50
24671741-0 2015 Uric acid induces oxidative stress via an activation of the renin-angiotensin system in 3T3-L1 adipocytes. Uric Acid 0-9 renin Homo sapiens 60-65
25301104-3 2015 Because polymorphisms are distributed randomly at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded assessment of the nature of the link between uric acid and atherosclerosis. Uric Acid 191-200 solute carrier family 2 member 9 Homo sapiens 101-106
25301104-8 2015 RESULTS: Serum uric acid level was dose-dependently associated with the T allele of rs734553, a polymorphism in SLC2A9 (P=8x10(-6)). Uric Acid 15-24 solute carrier family 2 member 9 Homo sapiens 112-118
24746974-12 2015 CONCLUSIONS: The present study showed for the first time that incorporation of 25 g/d of lupin protein into a variety of complex food products lowers total and LDL cholesterol, triacylglycerols, homocysteine, and uric acid in hypercholesterolemic subjects. Uric Acid 213-222 5'-nucleotidase, cytosolic IIIA Homo sapiens 89-94
24671741-3 2015 In the present study, we investigated whether uric acid upregulates renin-angiotensin system (RAS) expression in adipocytes. Uric Acid 46-55 renin Homo sapiens 68-73
24671741-10 2015 The uric acid upregulated both RAS (AGT, ACE1, renin, AT1R, and AT2R) mRNA expressions and angiotensin II protein secretion and caused a significant increase in ROS production in 3T3-L1 adipocytes. Uric Acid 4-13 angiotensin I converting enzyme Homo sapiens 41-45
24671741-10 2015 The uric acid upregulated both RAS (AGT, ACE1, renin, AT1R, and AT2R) mRNA expressions and angiotensin II protein secretion and caused a significant increase in ROS production in 3T3-L1 adipocytes. Uric Acid 4-13 renin Homo sapiens 47-52
24671741-10 2015 The uric acid upregulated both RAS (AGT, ACE1, renin, AT1R, and AT2R) mRNA expressions and angiotensin II protein secretion and caused a significant increase in ROS production in 3T3-L1 adipocytes. Uric Acid 4-13 angiotensin II receptor type 1 Homo sapiens 54-58
24671741-10 2015 The uric acid upregulated both RAS (AGT, ACE1, renin, AT1R, and AT2R) mRNA expressions and angiotensin II protein secretion and caused a significant increase in ROS production in 3T3-L1 adipocytes. Uric Acid 4-13 angiotensinogen Homo sapiens 91-105
25539818-8 2015 Next, we tested whether uric acid might mediate inflammasome activation in cells by treating mice with allopurinol and discovered that allopurinol treatment completely blocked caspase-1 activation in cells. Uric Acid 24-33 caspase 1 Mus musculus 176-185
25573404-1 2015 Mice infected with mouse hepatitis virus A59 (MHV-A59) develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH) with a concomitant enhancement of transaminases and release of alarmins such as uric acid and high-mobility group box protein 1 (HMGB1). Uric Acid 223-232 fumarylacetoacetate hydrolase Mus musculus 138-141
25428993-6 2015 Down-regulation of these SOD isoforms correlated with tyrosine (Tyr) nitration and both could be prevented by the peroxynitrite scavenger urate. Uric Acid 138-143 manganese superoxide dismutase 1 Arabidopsis thaliana 25-28
25435339-1 2015 BACKGROUND & AIMS: We have recently reported that a polymorphism (rs734553) in a major urate transporter gene (GLUT9) is a strong predictor of incident renal events in stage 2-5 CKD patients implying that life-time exposure to high uric acid levels may be causally implicated in CKD progression. Uric Acid 236-245 solute carrier family 2 member 9 Homo sapiens 115-120
26027255-4 2015 The increase of rate of mutations of hypoxanthine guanine phosphoribosyltransferase in lymphocytes with increasing of content of uric acid in blood and/or in urine was detected. Uric Acid 129-138 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 37-83
25688259-7 2015 We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). Uric Acid 60-69 solute carrier family 2 member 9 Homo sapiens 71-77
25315669-0 2015 Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling. Uric Acid 0-9 nuclear factor kappa B subunit 1 Homo sapiens 90-112
25315669-10 2015 UA-induced responses were ameliorated by organic anion transporter inhibitor probenecid and NF-kappaB inhibitor BAY11-7082. Uric Acid 0-2 nuclear factor kappa B subunit 1 Homo sapiens 92-101
25315669-12 2015 CONCLUSION: High concentration of UA exerts unfavorable effects directly on vascular endothelium via the NF-kappaB signaling pathway, the process of which requires intracellular uptake of UA. Uric Acid 34-36 nuclear factor kappa B subunit 1 Homo sapiens 105-114
25315669-12 2015 CONCLUSION: High concentration of UA exerts unfavorable effects directly on vascular endothelium via the NF-kappaB signaling pathway, the process of which requires intracellular uptake of UA. Uric Acid 188-190 nuclear factor kappa B subunit 1 Homo sapiens 105-114
25634581-0 2015 Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk. Uric Acid 20-29 solute carrier family 2 member 9 Homo sapiens 58-64
25634581-0 2015 Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk. Uric Acid 20-29 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 69-74
25634581-3 2015 We aim to explore the associations between genetic variants in uric acid related loci of SLC2A9 and ABCG2 and CHD risk in a Chinese population. Uric Acid 63-72 solute carrier family 2 member 9 Homo sapiens 89-95
25634581-3 2015 We aim to explore the associations between genetic variants in uric acid related loci of SLC2A9 and ABCG2 and CHD risk in a Chinese population. Uric Acid 63-72 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 100-105
25634581-5 2015 Association analysis between two uric acid related variants (SNP rs11722228 in SLC2A9 and rs4148152 in ABCG2) and CHD risk was performed by logistic regression model. Uric Acid 33-42 solute carrier family 2 member 9 Homo sapiens 79-85
25370766-2 2015 Missing XDH/XO activity leads to undetectable levels of uric acid excessively replaced by xanthine in serum/urine. Uric Acid 56-65 xanthine dehydrogenase Homo sapiens 8-11
25608940-0 2015 13C-enrichment of urinary uric acid after L-[Ring-2-13C]histidine dose in adult humans. Uric Acid 26-35 ring finger protein 2 Homo sapiens 45-51
25815140-2 2015 We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines. Uric Acid 122-127 solute carrier family 28 member 2 Homo sapiens 41-79
25815140-2 2015 We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines. Uric Acid 122-127 solute carrier family 28 member 2 Homo sapiens 81-86
25123940-0 2015 Spectroscopic analyses and studies on respective interaction of cyanuric acid and uric acid with bovine serum albumin and melamine. Uric Acid 68-77 albumin Homo sapiens 104-117
25123940-1 2015 In this work, the fluorescence quenching was used to study the interaction of cyanuric acid (CYA) and uric acid (UA) with bovine serum albumin (BSA) at two different temperatures (283 K and 310 K). Uric Acid 82-91 albumin Homo sapiens 129-142
25123940-1 2015 In this work, the fluorescence quenching was used to study the interaction of cyanuric acid (CYA) and uric acid (UA) with bovine serum albumin (BSA) at two different temperatures (283 K and 310 K). Uric Acid 113-115 albumin Homo sapiens 129-142
25608940-1 2015 We determined whether ring-2 carbon of histidine is folate-dependently transferred to carbons 8 (C8) and/or 2 (C2) in urinary uric acid in humans. Uric Acid 126-135 ring finger protein 2 Homo sapiens 22-28
26477273-0 2015 Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes. Uric Acid 32-37 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 61-66
25483146-3 2015 Quantitative detection of uric acid for rapid and routine diagnosis of early preeclampsia using electrochemical-surface enhanced Raman spectroscopy (EC-SERS) is presented herein. Uric Acid 26-35 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 152-156
25483146-6 2015 These results showed a linear relationship between the EC-SERS signal intensity and the uric acid concentration. Uric Acid 88-97 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 58-62
25236865-3 2015 Since its discovery in 1998, the substrates of BCRP have been rapidly expanding to include not only therapeutic agents but also physiological substances such as estrone-3-sulfate, 17beta-estradiol 17-(beta-D-glucuronide) and uric acid. Uric Acid 225-234 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 47-51
25252215-3 2015 NPT1 has been reported to mediate urate transport, but its physiologic role in regulating SUA in humans remains unclear. Uric Acid 34-39 solute carrier family 17 member 1 Homo sapiens 0-4
25252215-11 2015 The functional analysis using Xenopus oocyte expression systems showed that rs1165196 increases NPT1-mediated urate export. Uric Acid 110-115 solute carrier family 17 member 1 Homo sapiens 96-100
25757933-4 2015 Furthermore, uric acid locally activates the renin-angiotensin system, thus producing angiotensin II and subsequently increasing intracellular oxidative stress. Uric Acid 13-22 angiotensinogen Homo sapiens 86-100
25493383-7 2015 Incubation with UA for 6 or 12 h also increased AGT mRNA expression and AII protein synthesis. Uric Acid 16-18 angiotensinogen Homo sapiens 48-51
25493383-7 2015 Incubation with UA for 6 or 12 h also increased AGT mRNA expression and AII protein synthesis. Uric Acid 16-18 angiotensinogen Homo sapiens 72-75
25493383-10 2015 Our results suggested that UA triggers reactions including AII and ET-1 production in mesangial cells. Uric Acid 27-29 angiotensinogen Homo sapiens 59-62
25493383-10 2015 Our results suggested that UA triggers reactions including AII and ET-1 production in mesangial cells. Uric Acid 27-29 endothelin 1 Homo sapiens 67-71
26477273-8 2015 Both NAC and apocynin abolished the enhancing effects of urate on Kv1.5 expression. Uric Acid 57-62 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 66-71
26477273-9 2015 A urate-induced increase in the Kv1.5 proteins was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and was abolished by an ERK inhibitor, PD98059. Uric Acid 2-7 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 32-37
26477273-9 2015 A urate-induced increase in the Kv1.5 proteins was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and was abolished by an ERK inhibitor, PD98059. Uric Acid 2-7 mitogen-activated protein kinase 1 Mus musculus 85-122
25594175-5 2015 Importantly, in vivo data show that DA and DRD1 signaling prevent NLRP3 inflammasome-dependent inflammation, including neurotoxin-induced neuroinflammation, LPS-induced systemic inflammation, and monosodium urate crystal (MSU)-induced peritoneal inflammation. Uric Acid 196-212 dopamine receptor D1 Homo sapiens 43-47
25594175-5 2015 Importantly, in vivo data show that DA and DRD1 signaling prevent NLRP3 inflammasome-dependent inflammation, including neurotoxin-induced neuroinflammation, LPS-induced systemic inflammation, and monosodium urate crystal (MSU)-induced peritoneal inflammation. Uric Acid 196-212 NLR family pyrin domain containing 3 Homo sapiens 66-71
25449036-0 2015 The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung. Uric Acid 57-66 xanthine dehydrogenase Mus musculus 4-20
25449036-3 2015 Cells contain high levels of intracellular uric acid, which is produced when purines are oxidized by the enzyme xanthine oxidase. Uric Acid 43-52 xanthine dehydrogenase Mus musculus 112-128
25315617-7 2015 We conclude that OSA patients with increased uric acid concentration have increased risk of atheromatosis, as indicated by a higher level of soluble pro-atherogenic ligand CD40, and a higher prevalence of cardiovascular adverse events. Uric Acid 45-54 CD40 molecule Homo sapiens 172-176
25398539-7 2015 Caspase-dependent renal cell apoptosis was induced through attenuation of Bcl-2 and enhanced caspase-3 and caspase-9 expression by MSU crystals, which was significantly reversed by ascorbic acid and transfection of IL-1beta siRNA to HEK293 cells. Uric Acid 131-134 caspase 3 Homo sapiens 93-102
25398539-7 2015 Caspase-dependent renal cell apoptosis was induced through attenuation of Bcl-2 and enhanced caspase-3 and caspase-9 expression by MSU crystals, which was significantly reversed by ascorbic acid and transfection of IL-1beta siRNA to HEK293 cells. Uric Acid 131-134 caspase 9 Homo sapiens 107-116
25398539-7 2015 Caspase-dependent renal cell apoptosis was induced through attenuation of Bcl-2 and enhanced caspase-3 and caspase-9 expression by MSU crystals, which was significantly reversed by ascorbic acid and transfection of IL-1beta siRNA to HEK293 cells. Uric Acid 131-134 interleukin 1 beta Homo sapiens 215-223
26301880-3 2015 RESULTS: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Uric Acid 16-18 tumor necrosis factor Homo sapiens 243-270
26301880-3 2015 RESULTS: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Uric Acid 16-18 interleukin 6 Homo sapiens 275-288
24702708-3 2015 RESULTS: Male congenital heart disease patients with high serum uric acid concentrations (>7 mg/dl) showed significantly (p < 0.05) higher body mass index, serum creatinine, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and C-reactive protein concentrations than those male congenital heart disease patients with lower serum uric acid levels (<=7 mg/dl). Uric Acid 64-73 C-reactive protein Homo sapiens 255-273
24702708-4 2015 Meanwhile, female congenital heart disease patients with higher serum uric acid concentrations (>5.7 mg/dl) were significantly (p < 0.05) younger, more hypoxaemic, more obese, and with higher C-reactive protein and N-terminal-pro-B-type natriuretic peptide levels than those female congenital heart disease patients with lower serum uric acid concentrations (<=5.7 mg/dl). Uric Acid 70-79 C-reactive protein Homo sapiens 198-216
25967871-7 2015 The in vitro study showed that RNAi of MCSU caused the uric acid, human MCSU concentrations, the XOD and XDH activity levels among cellular proteins and culture supernatants to be extremely low relative to those of the control. Uric Acid 55-64 molybdenum cofactor sulfurase Homo sapiens 39-43
26299712-0 2015 High concentrations of uric acid inhibit angiogenesis via regulation of the Kruppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Uric Acid 23-32 Kruppel like factor 2 Homo sapiens 76-97
26299712-0 2015 High concentrations of uric acid inhibit angiogenesis via regulation of the Kruppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Uric Acid 23-32 vascular endothelial growth factor A Homo sapiens 98-134
26477273-9 2015 A urate-induced increase in the Kv1.5 proteins was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and was abolished by an ERK inhibitor, PD98059. Uric Acid 2-7 mitogen-activated protein kinase 1 Mus musculus 124-127
26477273-9 2015 A urate-induced increase in the Kv1.5 proteins was accompanied by phosphorylation of extracellular signal-regulated kinase (ERK), and was abolished by an ERK inhibitor, PD98059. Uric Acid 2-7 mitogen-activated protein kinase 1 Mus musculus 154-157
26477273-10 2015 NAC abolished phosphorylation of ERK by urate. Uric Acid 40-45 mitogen-activated protein kinase 1 Mus musculus 33-36
26477273-11 2015 CONCLUSIONS: Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes, which could be attributable to ERK phosphorylation and oxidative stress derived from nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. Uric Acid 27-32 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 59-64
26477273-11 2015 CONCLUSIONS: Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes, which could be attributable to ERK phosphorylation and oxidative stress derived from nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. Uric Acid 27-32 mitogen-activated protein kinase 1 Mus musculus 153-156
26477273-3 2015 METHODS AND RESULTS: The effects of urate on expression of Kv1.5 in cultured mouse atrial myocytes (HL-1 cells) using reverse transcriptase-PCR, immunoblots, flow cytometry and patch-clamp experiments were studied. Uric Acid 36-41 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 59-64
26477273-4 2015 Treatment with urate at 7 mg/dl for 24 h increased the Kv1.5 protein level, enhanced ultra-rapid delayed-rectifier K(+)channel currents and shortened action potential duration in HL-1 cells. Uric Acid 15-20 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 55-60
25739858-0 2015 Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia. Uric Acid 13-22 solute carrier family 22 member 12 Homo sapiens 30-38
26089585-6 2015 Patients with PRS-I superactivity demonstrate uric acid overproduction, hypotonia, ataxia, neurodevelopment abnormalities, and postlingual hearing impairment. Uric Acid 46-55 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 14-19
25739858-0 2015 Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia. Uric Acid 13-22 solute carrier family 22 member 12 Homo sapiens 40-45
25739858-9 2015 In the hypouricemia groups, serum UA in homozygous and compound heterozygous patients was significantly lower than in other groups, suggesting that severity of URAT1 dysfunction may influence the severity of hypouricemia. Uric Acid 34-36 solute carrier family 22 member 12 Homo sapiens 160-165
25739858-12 2015 CONCLUSIONS: Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients. Uric Acid 26-28 solute carrier family 22 member 12 Homo sapiens 36-44
25739858-12 2015 CONCLUSIONS: Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients. Uric Acid 26-28 solute carrier family 22 member 12 Homo sapiens 45-50
25760221-7 2015 An inverse correlation was found between variations of UA plasma levels observed before and after neurorehabilitation (Delta UA) and those of Cu/Zn SOD (Delta Cu/Zn SOD) (r= -0.386; P<0.001). Uric Acid 55-57 superoxide dismutase 1 Homo sapiens 142-151
25760221-7 2015 An inverse correlation was found between variations of UA plasma levels observed before and after neurorehabilitation (Delta UA) and those of Cu/Zn SOD (Delta Cu/Zn SOD) (r= -0.386; P<0.001). Uric Acid 55-57 superoxide dismutase 1 Homo sapiens 159-168
26059354-0 2015 The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Uric Acid 12-21 renin binding protein Homo sapiens 66-69
26005877-4 2015 At the tissue level, chronic exposure to increased uric acid has been shown to promote vascular changes leading to renal ischemia as well as stimulation of the renin angiotensin system. Uric Acid 51-60 renin Homo sapiens 160-165
26221174-2 2015 The present study was undertaken to evaluate the therapeutic effect of PRP15 in rat gouty arthritis induced by monosodium urate (MSU) crystals. Uric Acid 111-127 proline-rich protein 15 Rattus norvegicus 71-76
26221174-2 2015 The present study was undertaken to evaluate the therapeutic effect of PRP15 in rat gouty arthritis induced by monosodium urate (MSU) crystals. Uric Acid 129-132 proline-rich protein 15 Rattus norvegicus 71-76
26005877-5 2015 Furthermore, uric acid has been shown to promote the development of insulin resistance, hypertrglyceridemia and haepatic steatosis through pro-oxidative mechanisms. Uric Acid 13-22 insulin Homo sapiens 68-75
26435646-0 2015 Urate crystals induce NLRP3 inflammasome-dependent IL-1beta secretion and proliferation in isolated primary human T-cells. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 22-27
26005870-1 2015 During human evolution, the accumulation of loss of function mutations of the uricase gene led progressively to the lack of the ability to metabolize uric acid into further end-products. Uric Acid 150-159 urate oxidase (pseudogene) Homo sapiens 78-85
26005873-1 2015 Recent studies have revealed an association between elevated levels of uric acid and conditions correlated to chronic kidney diseases such as hypertension, cardiovascular and cerebral disease, insulin resistance. Uric Acid 71-80 insulin Homo sapiens 193-200
26435646-0 2015 Urate crystals induce NLRP3 inflammasome-dependent IL-1beta secretion and proliferation in isolated primary human T-cells. Uric Acid 0-5 interleukin 1 beta Homo sapiens 51-59
26435646-8 2015 RESULTS: Urate induced caspase-1 activation and IL-1beta release by T-cells. Uric Acid 9-14 caspase 1 Homo sapiens 23-32
26435646-8 2015 RESULTS: Urate induced caspase-1 activation and IL-1beta release by T-cells. Uric Acid 9-14 interleukin 1 beta Homo sapiens 48-56
26435646-10 2015 Glyburide inhibited urate-induced caspase-1 activation, IL-1beta secretion and proliferation. Uric Acid 20-25 caspase 1 Homo sapiens 34-43
26435646-10 2015 Glyburide inhibited urate-induced caspase-1 activation, IL-1beta secretion and proliferation. Uric Acid 20-25 interleukin 1 beta Homo sapiens 56-64
26435646-11 2015 CONCLUSIONS: Urate, a well defined danger signal, stimulates directly human T-cells in a NLRP3 infmmasomela-dependent way. Uric Acid 13-18 NLR family pyrin domain containing 3 Homo sapiens 89-94
25767547-1 2015 Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a rare inborn error of purine metabolism and is characterized by uric acid overproduction along with a variety of neurological manifestations that depend on a degree of the enzymatic deficiency. Uric Acid 137-146 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 62-67
25810959-0 2015 Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women. Uric Acid 22-31 insulin Homo sapiens 81-88
25810959-4 2015 Stratification analysis and independent t-test was used to assess the association between uric acid and birth weights regarding to insulin resistance. Uric Acid 90-99 insulin Homo sapiens 131-138
25810959-7 2015 CONCLUSIONS: Higher mid - gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non-insulin resistance women. Uric Acid 42-51 insulin Homo sapiens 161-168
26328636-8 2015 CONCLUSION: The long-term effective control of serum uric acid by allopurinol may improve insulin resistance, decrease the serum levels of hs-CRP, reduce the carotid IMT, and may delay the development of atherosclerosis in patients with T2DM and asymptomatic HUA. Uric Acid 53-62 insulin Homo sapiens 90-97
26347587-0 2015 Monosodium Urate in the Presence of RANKL Promotes Osteoclast Formation through Activation of c-Jun N-Terminal Kinase. Uric Acid 0-16 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 36-41
26067715-9 2015 CONCLUSIONS: These findings suggest, for the first time in humans, that higher serum uric acid levels are associated significantly with Ra in subjects with Cin > 60 ml/min/1.73m(2). Uric Acid 85-94 pyridoxal phosphatase Homo sapiens 156-159
26347587-1 2015 The aim of this study was to clarify the role of monosodium urate (MSU) crystals in receptor activator of nuclear factor kB ligand- (RANKL-) RANK-induced osteoclast formation. Uric Acid 67-70 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 84-131
25382640-5 2015 Estimated glomerular filtration rate was reduced in patients with high UA levels of both sexes (65+-17 vs 72+-16 mL/min/1.73 m(2) , P<.001, for women; 70+-16 vs 76+-15 mL/min/1.73 m(2) , P<.03, for men). Uric Acid 71-73 CD59 molecule (CD59 blood group) Homo sapiens 116-121
25673130-5 2015 The difference in UA levels between 2-year follow-up and baseline related to EDSS sustained progression (p < 0.001; OR = 0.099), and presented a trend for clinical relapses at logistic regression (p = 0.211; OR = 0.711) and for the time to relapse at Cox regression (p = 0.236; HR = 0.792). Uric Acid 18-20 cytochrome c oxidase subunit 8A Homo sapiens 254-257
26347587-1 2015 The aim of this study was to clarify the role of monosodium urate (MSU) crystals in receptor activator of nuclear factor kB ligand- (RANKL-) RANK-induced osteoclast formation. Uric Acid 67-70 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 133-139
26347587-0 2015 Monosodium Urate in the Presence of RANKL Promotes Osteoclast Formation through Activation of c-Jun N-Terminal Kinase. Uric Acid 0-16 jun proto-oncogene Mus musculus 94-99
26347587-1 2015 The aim of this study was to clarify the role of monosodium urate (MSU) crystals in receptor activator of nuclear factor kB ligand- (RANKL-) RANK-induced osteoclast formation. Uric Acid 49-65 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 84-131
26347587-1 2015 The aim of this study was to clarify the role of monosodium urate (MSU) crystals in receptor activator of nuclear factor kB ligand- (RANKL-) RANK-induced osteoclast formation. Uric Acid 49-65 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 133-139
25514209-0 2014 Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. Uric Acid 0-9 NADPH oxidase 4 Homo sapiens 116-121
24947824-12 2015 The absolute changes in OPG showed a significant positive correlation with the changes in serum uric acid (p < 0.05) and negative correlation with the changes in FMD (p < 0.01) in patients with hyperuricemia during the course of hypouricemic therapy. Uric Acid 96-105 TNF receptor superfamily member 11b Homo sapiens 24-27
26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 interleukin 6 Homo sapiens 55-59
26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 intercellular adhesion molecule 1 Homo sapiens 61-67
26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 tumor necrosis factor Homo sapiens 69-78
26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 C-C motif chemokine ligand 2 Homo sapiens 84-89
26539255-8 2015 Using siRNA, inhibition of Notch-1 signaling significantly impeded the expressions of inflammatory cytokines under UA treatment. Uric Acid 115-117 notch receptor 1 Homo sapiens 27-34
26539255-11 2015 CONCLUSIONS: In summary, our findings indicated that Notch-1 plays an important role in the UA-induced inflammatory response, and the downregulation of Notch-1 by EGCG could be an effective approach to decrease inflammation and oxidative stress induced by UA. Uric Acid 92-94 notch receptor 1 Homo sapiens 53-60
26539255-11 2015 CONCLUSIONS: In summary, our findings indicated that Notch-1 plays an important role in the UA-induced inflammatory response, and the downregulation of Notch-1 by EGCG could be an effective approach to decrease inflammation and oxidative stress induced by UA. Uric Acid 256-258 notch receptor 1 Homo sapiens 53-60
26539255-11 2015 CONCLUSIONS: In summary, our findings indicated that Notch-1 plays an important role in the UA-induced inflammatory response, and the downregulation of Notch-1 by EGCG could be an effective approach to decrease inflammation and oxidative stress induced by UA. Uric Acid 256-258 notch receptor 1 Homo sapiens 152-159
26841550-6 2015 At the same time, the amount of energy expenditure at rest, calculated per kg lean body weight, and serum content of uric acid in were significantly higher in individuals with KCNJ11 rs5219 polymorphism, both in homo-, and in the heterozygous type. Uric Acid 117-126 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 176-182
26852537-8 2015 In individuals with the AA genotype rs9939609 FTO gene compared with the TT genotype had significantly lower levels of HDL cholesterol and serum iron in the background significantly elevated concentrations of uric acid. Uric Acid 209-218 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 46-49
25362243-7 2015 The DREAM-Phil Bowen ALS Prediction Prize4Life challenge also identified several potential nonstandard predictors of disease progression including uric acid, creatinine and surprisingly, blood pressure, shedding light on ALS pathobiology. Uric Acid 147-156 potassium voltage-gated channel interacting protein 3 Homo sapiens 4-9
25981580-0 2015 Characterization of a Thermostable Uricase Isolated from Bacillus firmus DWD-33 and its Application for Uric Acid Quantification in Human Serum. Uric Acid 104-113 urate oxidase (pseudogene) Homo sapiens 35-42
25981580-11 2015 It was possible to determine uric acid in human sera with the enzyme with none of the tested uric acid analogs being a competitive substrate, indicating a high specificity of uricase with respect to uric acid measurement in vitro for uric acid concentration up to 500 micromol/L. Uric Acid 29-38 urate oxidase (pseudogene) Homo sapiens 175-182
25514209-5 2014 Uric acid up-regulated Bax (+60% with respect to Ctrl; p<0.05) and down regulated X-linked inhibitor of apoptosis protein. Uric Acid 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 23-26
25514209-7 2014 Uric acid induced changes in the mitochondrial membrane, elevations in reactive oxygen species and a pronounced up-regulation of NOX 4 mRNA and protein (p<0.05). Uric Acid 0-9 NADPH oxidase 4 Homo sapiens 129-134
25514209-10 2014 In summary, our data show that uric acid increases the permissiveness of proximal tubule kidney cells to apoptosis by triggering a pathway involving NADPH oxidase signalling and URAT 1 transport. Uric Acid 31-40 solute carrier family 22 member 12 Homo sapiens 178-184
25233041-6 2014 RBP4 concentration was significantly associated with cardiovascular risk factors, including body mass index and concentrations of triglycerides, high-density lipoprotein cholesterol, uric acid, high-sensitivity C reactive protein and adiponectin (P < 0.01 each). Uric Acid 183-192 retinol binding protein 4 Homo sapiens 0-4
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 76-85 xanthine dehydrogenase Homo sapiens 0-22
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 76-85 xanthine dehydrogenase Homo sapiens 41-44
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 133-142 xanthine dehydrogenase Homo sapiens 0-22
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 133-142 xanthine dehydrogenase Homo sapiens 41-44
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 144-146 xanthine dehydrogenase Homo sapiens 0-22
25512781-2 2014 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Uric Acid 144-146 xanthine dehydrogenase Homo sapiens 41-44
25512781-8 2014 Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Uric Acid 86-88 xanthine dehydrogenase Homo sapiens 128-131
25512781-8 2014 Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Uric Acid 209-211 xanthine dehydrogenase Homo sapiens 128-131
25512781-8 2014 Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Uric Acid 209-211 xanthine dehydrogenase Homo sapiens 128-131
25512781-9 2014 Interventional studies for UA generation, not UA excretion revealed XDH/XO can be the therapeutic target for vascular injury and renal dysfunction. Uric Acid 27-29 xanthine dehydrogenase Homo sapiens 68-71
25312638-0 2014 Relation of serum uric acid levels and outcomes among patients hospitalized for worsening heart failure with reduced ejection fraction (from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan trial). Uric Acid 18-27 arginine vasopressin Homo sapiens 157-168
25501427-1 2014 Uric acid is associated with hypertension and increased renin-angiotensin system activity, although this relationship diminishes after chronic exposure to high levels. Uric Acid 0-9 renin Homo sapiens 56-61
25501427-3 2014 We examined the association between uric acid and vascular measures at baseline and in response to angiotensin-II challenge in young healthy humans. Uric Acid 36-45 angiotensinogen Homo sapiens 99-113
25501427-7 2014 In stark contrast, a significant association was observed between uric acid and blood pressure at baseline (systolic blood pressure, P = 0.005; diastolic blood pressure, P = 0.02) and in response to angiotensin-II (systolic blood pressure, P = 0.035; diastolic blood pressure, P = 0.056) in women. Uric Acid 66-75 angiotensinogen Homo sapiens 199-213
25501427-9 2014 When all subjects were stratified according to high (>300 mumol/L) or low (<=300 mumol/L) uric acid levels, only the low uric acid group showed a positive association between uric acid and measures of vascular tone at baseline and in response to angiotensin-II. Uric Acid 127-136 angiotensinogen Homo sapiens 252-266
25501427-9 2014 When all subjects were stratified according to high (>300 mumol/L) or low (<=300 mumol/L) uric acid levels, only the low uric acid group showed a positive association between uric acid and measures of vascular tone at baseline and in response to angiotensin-II. Uric Acid 127-136 angiotensinogen Homo sapiens 252-266
25474351-9 2014 One PheWAS result was ABCG2 missense SNP rs2231142, associated with uric acid levels in both non-Hispanic whites and Mexican Americans, protoporphyrin levels in non-Hispanic whites and Mexican Americans, and blood pressure levels in Mexican Americans. Uric Acid 68-77 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 22-27
25445147-4 2014 Silica and monosodium urate crystal-treated macrophages with undisturbed lysosomes demonstrated strong co-localization of ASC and Caspase-1, indicative of NLRP3 inflammasome activation. Uric Acid 11-27 PYD and CARD domain containing Homo sapiens 122-125
25445147-4 2014 Silica and monosodium urate crystal-treated macrophages with undisturbed lysosomes demonstrated strong co-localization of ASC and Caspase-1, indicative of NLRP3 inflammasome activation. Uric Acid 11-27 caspase 1 Homo sapiens 130-139
25445147-4 2014 Silica and monosodium urate crystal-treated macrophages with undisturbed lysosomes demonstrated strong co-localization of ASC and Caspase-1, indicative of NLRP3 inflammasome activation. Uric Acid 11-27 NLR family pyrin domain containing 3 Homo sapiens 155-160
25463089-4 2014 In particular, uric acid may have a protective as well as a detrimental role in vascular alterations, thus justifying the multi-directional effects of XOR inhibition. Uric Acid 15-24 xanthine dehydrogenase Homo sapiens 151-154
25257975-7 2014 RESULTS: Serum urate concentrations were 0.69mg/dl lower among individuals with >=4 SLC2A9 minor alleles as compared to those with <=2 (p = 0.0002). Uric Acid 15-20 solute carrier family 2 member 9 Homo sapiens 84-90
24026676-0 2014 Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. Uric Acid 118-123 solute carrier family 2 member 9 Homo sapiens 76-82
24026676-2 2014 Genetic variants in SLC2A9, that exchanges uric acid for glucose and fructose, associate with gout. Uric Acid 43-52 solute carrier family 2 member 9 Homo sapiens 20-26
24026676-14 2014 The interaction data suggest that SLC2A9-mediated renal uric acid excretion is physiologically influenced by intake of simple sugars derived from SSB, with SSB exposure negating the gout risk discrimination of SLC2A9. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 34-40
24026676-14 2014 The interaction data suggest that SLC2A9-mediated renal uric acid excretion is physiologically influenced by intake of simple sugars derived from SSB, with SSB exposure negating the gout risk discrimination of SLC2A9. Uric Acid 56-65 small RNA binding exonuclease protection factor La Homo sapiens 146-149
24026676-14 2014 The interaction data suggest that SLC2A9-mediated renal uric acid excretion is physiologically influenced by intake of simple sugars derived from SSB, with SSB exposure negating the gout risk discrimination of SLC2A9. Uric Acid 56-65 small RNA binding exonuclease protection factor La Homo sapiens 156-159
25015064-1 2014 Uric acid (UA) is generalized as a byproduct the terminal steps of purine catabolism, which are catalyzed by xanthine oxidoreductase. Uric Acid 0-9 xanthine dehydrogenase Homo sapiens 109-132
25229885-0 2014 Complement C5a potentiates uric acid crystal-induced IL-1beta production. Uric Acid 27-36 complement C5a receptor 1 Homo sapiens 11-14
25229885-0 2014 Complement C5a potentiates uric acid crystal-induced IL-1beta production. Uric Acid 27-36 interleukin 1 beta Homo sapiens 53-61
25229885-2 2014 The pathogenesis of gout was identified as uric acid crystal deposition in the joints that activates inflammasome, leading to IL-1beta release. Uric Acid 43-52 interleukin 1 beta Homo sapiens 126-134
25229885-3 2014 However, little is known about the interaction between complement activation and monosodium urate/uric acid (MSU) crystal-induced inflammasome activation or IL-1beta production. Uric Acid 81-97 branched chain keto acid dehydrogenase E1 subunit alpha Homo sapiens 109-112
25229885-3 2014 However, little is known about the interaction between complement activation and monosodium urate/uric acid (MSU) crystal-induced inflammasome activation or IL-1beta production. Uric Acid 98-107 branched chain keto acid dehydrogenase E1 subunit alpha Homo sapiens 109-112
25229885-7 2014 Our results provide insight into the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production. Uric Acid 120-129 complement C5a receptor 1 Homo sapiens 45-48
25229885-7 2014 Our results provide insight into the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production. Uric Acid 120-129 interleukin 1 beta Homo sapiens 146-154
25554068-3 2014 Finally, through their ability to reduce intraglomerular pressure, systemic blood pressure and plasma uric acid concentration, the SGLT-2 inhibitors offers the possibility of kidney protection. Uric Acid 102-111 solute carrier family 5 member 2 Homo sapiens 131-137
25015064-1 2014 Uric acid (UA) is generalized as a byproduct the terminal steps of purine catabolism, which are catalyzed by xanthine oxidoreductase. Uric Acid 11-13 xanthine dehydrogenase Homo sapiens 109-132
25202817-9 2014 Adiponectin correlated inversely with BCAA and uric acid (R(2) = 0.268, P = .0212) in males but not females. Uric Acid 47-56 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
25295417-9 2014 Serum UA levels significantly correlate with early-phase insulin secretion in nondiabetic Japanese women. Uric Acid 6-8 insulin Homo sapiens 57-64
25247018-7 2014 RESULTS: Uric acid levels were negatively associated with eGFR (P = 0.002), especially in patients with CKD (eGFR < 60 mL/min/1.73 m(2)) (P < 0.001). Uric Acid 9-18 CD59 molecule (CD59 blood group) Homo sapiens 125-130
25705163-2 2014 Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. Uric Acid 43-52 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 80-123
25705163-2 2014 Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. Uric Acid 43-52 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 125-130
25705163-3 2014 We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. Uric Acid 112-121 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 97-102
25705163-5 2014 The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Uric Acid 61-70 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 25-30
25705163-9 2014 This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults. Uric Acid 75-84 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 59-64
25202817-12 2014 A metabolic signature comprising BCAA and uric acid correlates positively with HOMA-IR in males and TG to HDL ratio in females and inversely with adiponectin in males but not females. Uric Acid 42-51 adiponectin, C1Q and collagen domain containing Homo sapiens 146-157
24506204-4 2014 After partial protein purification, the enzyme responsible for retinoic acid biosynthesis was identified and quantified as XDH by immunoassay, by its ability to oxidize xanthine to uric acid and its sensitivity to the inhibitory effect of oxypurinol. Uric Acid 181-190 xanthine dehydrogenase Homo sapiens 123-126
25417683-1 2014 We report 2 cases of familial juvenile hyperuricemic nephropathy, a rare autosomal dominant disorder characterized by uromodulin gene mutations leading to hyperuricemia secondary to profound renal uric acid underexcretion, gout, and chronic renal disease. Uric Acid 197-206 uromodulin Homo sapiens 118-128
25338212-6 2014 Cupressuflavone pretreatment markedly inhibited the CCl4-induced increase in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, creatinine, uric acid, urea, and malondialdehyde levels in a dose-dependent manner (p < 0.001 at all the tested doses). Uric Acid 201-210 chemokine (C-C motif) ligand 4 Mus musculus 52-56
24687403-8 2014 In addition, a newer xanthine oxidoreductase inhibitor, febuxostat, may also be effective in the prevention of calcium stones, as it reduces urinary uric acid excretion. Uric Acid 149-158 xanthine dehydrogenase Homo sapiens 21-44
25149895-0 2014 Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects. Uric Acid 83-92 insulin like growth factor 1 Homo sapiens 16-44
25149895-2 2014 Acute IGF-1 infusion decreases uric acid concentration in healthy individuals. Uric Acid 31-40 insulin like growth factor 1 Homo sapiens 6-11
25149895-3 2014 In this study, we aimed to examine the relationship between IGF-1 and uric acid levels. Uric Acid 70-79 insulin like growth factor 1 Homo sapiens 60-65
25149895-5 2014 Significant differences in uric acid concentration, measured by the URICASE/POD method were observed between low (quartile 1), intermediate (quartile 2 and 3), and high (quartile 4) IGF-1 levels groups after adjusting for age, gender, and body mass index (P = 0.02). Uric Acid 27-36 insulin like growth factor 1 Homo sapiens 182-187
25149895-7 2014 To clarify the molecular links between IGF-1 and uric acid, we performed an in vitro study, incubating human hepatoma cells with uric acid for 24 or 48 h in the presence of GH and observed a 21% and 26% decrease, respectively, in GH-stimulated IGF-1 mRNA expression (P = 0.02 and P = 0.012, respectively). Uric Acid 129-138 insulin like growth factor 1 Homo sapiens 39-44
25149895-8 2014 This effect appears to be mediated by uric acid ability to down regulate GH intracellular signaling; in fact we observed a significant decrease of GH activated JAK2 and Stat5 phosphorylation. Uric Acid 38-47 Janus kinase 2 Homo sapiens 160-164
25149895-8 2014 This effect appears to be mediated by uric acid ability to down regulate GH intracellular signaling; in fact we observed a significant decrease of GH activated JAK2 and Stat5 phosphorylation. Uric Acid 38-47 signal transducer and activator of transcription 5A Homo sapiens 169-174
25149895-9 2014 CONCLUSIONS: These data demonstrate an inverse relationship between IGF-1 and uric acid levels in adults and suggest that uric acid might affect hepatic IGF-1 synthesis. Uric Acid 78-87 insulin like growth factor 1 Homo sapiens 68-73
25149895-9 2014 CONCLUSIONS: These data demonstrate an inverse relationship between IGF-1 and uric acid levels in adults and suggest that uric acid might affect hepatic IGF-1 synthesis. Uric Acid 122-131 insulin like growth factor 1 Homo sapiens 153-158
25538909-9 2014 Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878). Uric Acid 182-191 lipocalin 2 Homo sapiens 6-10
25432151-4 2014 Furthermore, the gene (A1CF) encoding the complementation factor for the APOB mRNA-editing enzyme is associated with urate levels. Uric Acid 117-122 APOBEC1 complementation factor Homo sapiens 23-27
25159399-3 2014 Glucose oxidase and uricase, as model enzymes, were immobilised on top of PBG/CNT/CFE and PTH/CNT/CFE for glucose and uric acid (UA) biosensing. Uric Acid 118-127 urate oxidase (pseudogene) Homo sapiens 20-27
25159399-3 2014 Glucose oxidase and uricase, as model enzymes, were immobilised on top of PBG/CNT/CFE and PTH/CNT/CFE for glucose and uric acid (UA) biosensing. Uric Acid 129-131 urate oxidase (pseudogene) Homo sapiens 20-27
25432151-4 2014 Furthermore, the gene (A1CF) encoding the complementation factor for the APOB mRNA-editing enzyme is associated with urate levels. Uric Acid 117-122 apolipoprotein B Homo sapiens 73-77
25454754-7 2014 The pPD/GOx/GR electrode showed excellent selectivity in the presence of dopamine and uric acid. Uric Acid 86-95 hydroxyacid oxidase 1 Homo sapiens 8-11
25283508-0 2014 Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population. Uric Acid 6-15 solute carrier family 2 member 9 Homo sapiens 64-70
25283508-0 2014 Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population. Uric Acid 6-15 splicing factor 1 Homo sapiens 72-75
25283508-0 2014 Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population. Uric Acid 6-15 glucokinase regulator Homo sapiens 81-85
25283508-6 2014 RESULTS: In males after adjustments for age and BMI, GCKR rs780094, SLC2A9 rs11722228 and SF1 rs606458 were associated with the uric acid concentrations, which were statistically significant (P=0.016, 0.001 and 0.03, respectively), whereas SLC2A9 rs3775948 was marginally associated with the uric acid concentrations (P=0.071). Uric Acid 128-137 glucokinase regulator Homo sapiens 53-57
25283508-6 2014 RESULTS: In males after adjustments for age and BMI, GCKR rs780094, SLC2A9 rs11722228 and SF1 rs606458 were associated with the uric acid concentrations, which were statistically significant (P=0.016, 0.001 and 0.03, respectively), whereas SLC2A9 rs3775948 was marginally associated with the uric acid concentrations (P=0.071). Uric Acid 128-137 solute carrier family 2 member 9 Homo sapiens 68-74
25283508-6 2014 RESULTS: In males after adjustments for age and BMI, GCKR rs780094, SLC2A9 rs11722228 and SF1 rs606458 were associated with the uric acid concentrations, which were statistically significant (P=0.016, 0.001 and 0.03, respectively), whereas SLC2A9 rs3775948 was marginally associated with the uric acid concentrations (P=0.071). Uric Acid 128-137 splicing factor 1 Homo sapiens 90-93
25283508-6 2014 RESULTS: In males after adjustments for age and BMI, GCKR rs780094, SLC2A9 rs11722228 and SF1 rs606458 were associated with the uric acid concentrations, which were statistically significant (P=0.016, 0.001 and 0.03, respectively), whereas SLC2A9 rs3775948 was marginally associated with the uric acid concentrations (P=0.071). Uric Acid 292-301 splicing factor 1 Homo sapiens 90-93
25283508-7 2014 In females, SLC22A12 rs506338 was also marginally associated with the uric acid concentrations (P=0.057). Uric Acid 70-79 solute carrier family 22 member 12 Homo sapiens 12-20
25283508-10 2014 CONCLUSION: The SLC2A9 rs11722228, SF1 rs606458 and GCKR rs780094 variants modulate uric acid concentrations in Chinese males, while SF1 rs606458 and SLC2A9 rs3775948 are associated with the uric acid concentrations in both Chinese males and females. Uric Acid 84-93 solute carrier family 2 member 9 Homo sapiens 16-22
25283508-10 2014 CONCLUSION: The SLC2A9 rs11722228, SF1 rs606458 and GCKR rs780094 variants modulate uric acid concentrations in Chinese males, while SF1 rs606458 and SLC2A9 rs3775948 are associated with the uric acid concentrations in both Chinese males and females. Uric Acid 84-93 splicing factor 1 Homo sapiens 35-38
25283508-10 2014 CONCLUSION: The SLC2A9 rs11722228, SF1 rs606458 and GCKR rs780094 variants modulate uric acid concentrations in Chinese males, while SF1 rs606458 and SLC2A9 rs3775948 are associated with the uric acid concentrations in both Chinese males and females. Uric Acid 84-93 glucokinase regulator Homo sapiens 52-56
25283508-10 2014 CONCLUSION: The SLC2A9 rs11722228, SF1 rs606458 and GCKR rs780094 variants modulate uric acid concentrations in Chinese males, while SF1 rs606458 and SLC2A9 rs3775948 are associated with the uric acid concentrations in both Chinese males and females. Uric Acid 191-200 solute carrier family 2 member 9 Homo sapiens 16-22
25115772-8 2014 Diabetes-induced abnormal liver (aspartate aminotransferase and alanine aminotransferase) and kidney (blood urea nitrogen and uric acid) parameters were corrected in GLP-1-treated rats compared to controls. Uric Acid 126-135 glucagon Rattus norvegicus 166-171
25374817-0 2014 Role of insulin resistance in uric acid nephrolithiasis. Uric Acid 30-39 insulin Homo sapiens 8-15
25374817-3 2014 This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation, in particular. Uric Acid 190-199 insulin Homo sapiens 167-174
25374817-4 2014 We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis. Uric Acid 101-110 insulin Homo sapiens 78-85
25091900-8 2014 Furthermore, when we analyzed the effect of antioxidants on protein radical formation during LDL oxidation, we found that ascorbate, urate, and Trolox dose-dependently reduced apo B-100 free radical formation in LDL exposed to Cu(2+). Uric Acid 133-138 apolipoprotein B Homo sapiens 176-185
25400699-8 2014 CONCLUSIONS: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance. Uric Acid 108-110 insulin Homo sapiens 141-148
25064339-0 2014 Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome. Uric Acid 24-40 NLR family, pyrin domain containing 3 Rattus norvegicus 84-89
24899662-6 2014 MPO protein in patients" plasma was related to urate concentration (r = 0.5, P < 0.001). Uric Acid 47-52 myeloperoxidase Homo sapiens 0-3
24899662-11 2014 Oxypurinol was a substrate for purified MPO that enhanced the oxidation of urate. Uric Acid 75-80 myeloperoxidase Homo sapiens 40-43
24899662-12 2014 CONCLUSION: Increased concentrations of urate in gout lead to the release of MPO from neutrophils and the oxidation of urate. Uric Acid 40-45 myeloperoxidase Homo sapiens 77-80
25356596-11 2014 CONCLUSIONS: The APOE-epsilon2epsilon3 genotype and the APOE-epsilon2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon2 allele have a higher risk of hyperuricemia than non-carriers. Uric Acid 103-112 apolipoprotein E Homo sapiens 17-21
25356596-11 2014 CONCLUSIONS: The APOE-epsilon2epsilon3 genotype and the APOE-epsilon2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon2 allele have a higher risk of hyperuricemia than non-carriers. Uric Acid 103-112 apolipoprotein E Homo sapiens 56-60
25356596-11 2014 CONCLUSIONS: The APOE-epsilon2epsilon3 genotype and the APOE-epsilon2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon2 allele have a higher risk of hyperuricemia than non-carriers. Uric Acid 103-112 apolipoprotein E Homo sapiens 56-60
25150490-10 2014 In addition a UA-dependent downregulation of eIF4, an upregulation of UPS and an increase in HIF-1alpha were detected. Uric Acid 14-16 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-103
24659142-11 2014 The level of plasma miR-21 was not associated with the level of white blood cells (P = 0.4284), red blood cells (P = 0.4079), and platelets (P = 0.4961), but significantly correlated with the level of plasma complement C3 (r = -0.5297, P = 0.0004), C4 (r = -0.4732, P = 0.0020), and serum uric acid (r = 0.3932, P = 0.0121) in SLE patients. Uric Acid 289-298 microRNA 21 Homo sapiens 20-26
24917566-7 2014 Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). Uric Acid 0-9 CIMT Homo sapiens 30-34
24917566-11 2014 CONCLUSION: The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. Uric Acid 33-42 CIMT Homo sapiens 48-52
24943488-0 2014 Contribution of mast cell-derived interleukin-1beta to uric acid crystal-induced acute arthritis in mice. Uric Acid 55-64 interleukin 1 beta Mus musculus 34-51
25286413-1 2014 The urate transporter, GLUT9, is responsible for the basolateral transport of urate in the proximal tubule of human kidneys and in the placenta, playing a central role in uric acid homeostasis. Uric Acid 4-9 solute carrier family 2 member 9 Homo sapiens 23-28
25286413-1 2014 The urate transporter, GLUT9, is responsible for the basolateral transport of urate in the proximal tubule of human kidneys and in the placenta, playing a central role in uric acid homeostasis. Uric Acid 171-180 solute carrier family 2 member 9 Homo sapiens 23-28
25286413-2 2014 GLUT9 shares the least homology with other members of the glucose transporter family, especially with the glucose transporting members GLUT1-4 and is the only member of the GLUT family to transport urate. Uric Acid 198-203 solute carrier family 2 member 9 Homo sapiens 0-5
25286413-2 2014 GLUT9 shares the least homology with other members of the glucose transporter family, especially with the glucose transporting members GLUT1-4 and is the only member of the GLUT family to transport urate. Uric Acid 198-203 solute carrier family 2 member 1 Homo sapiens 0-4
25141984-4 2014 The enzyme electrode detected uric acid level as low as 5.0 muM at a signal-to-noise ratio of 3, within 7 s at pH 8.5 and 40 C. The biosensor showed a linear working range, 0.005 to 0.8 mM for uric acid with a sensitivity of 0.03 mA muM(-1) cm(-2). Uric Acid 30-39 latexin Homo sapiens 60-63
25141984-4 2014 The enzyme electrode detected uric acid level as low as 5.0 muM at a signal-to-noise ratio of 3, within 7 s at pH 8.5 and 40 C. The biosensor showed a linear working range, 0.005 to 0.8 mM for uric acid with a sensitivity of 0.03 mA muM(-1) cm(-2). Uric Acid 30-39 PWWP domain containing 3A, DNA repair factor Homo sapiens 234-240
25141984-4 2014 The enzyme electrode detected uric acid level as low as 5.0 muM at a signal-to-noise ratio of 3, within 7 s at pH 8.5 and 40 C. The biosensor showed a linear working range, 0.005 to 0.8 mM for uric acid with a sensitivity of 0.03 mA muM(-1) cm(-2). Uric Acid 194-203 latexin Homo sapiens 60-63
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 stearoyl-CoA desaturase Homo sapiens 178-182
25141984-4 2014 The enzyme electrode detected uric acid level as low as 5.0 muM at a signal-to-noise ratio of 3, within 7 s at pH 8.5 and 40 C. The biosensor showed a linear working range, 0.005 to 0.8 mM for uric acid with a sensitivity of 0.03 mA muM(-1) cm(-2). Uric Acid 194-203 PWWP domain containing 3A, DNA repair factor Homo sapiens 234-240
24246837-5 2014 ApoA-I, HDL-cholesterol and uric acid were uniformly positive independent linear covariates of total and HDL PL, apoA-I even in participants without MetS. Uric Acid 28-37 apolipoprotein A1 Homo sapiens 113-119
25186106-7 2014 Uric acid levels were directly related with fasting and post-OGTT plasma insulin and with the HOMA index and inversely with 24-h creatinine clearance. Uric Acid 0-9 insulin Homo sapiens 73-80
24821702-0 2014 Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid. Uric Acid 127-136 solute carrier family 2 member 9 Homo sapiens 90-96
25220477-11 2014 DA-induced PTN was insensitive to l-NMMA but was blunted by apocynin, superoxide dismutase, catalase and uric acid. Uric Acid 105-114 pleiotrophin Rattus norvegicus 11-14
25043284-4 2014 Serum hepcidin concentrations were strongly correlated positively with iron, ferritin, urea, and uric acid. Uric Acid 97-106 hepcidin antimicrobial peptide Homo sapiens 6-14
25111690-0 2014 Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Uric Acid 0-9 sterol regulatory element binding transcription factor 1 Homo sapiens 86-94
25111690-3 2014 Here we demonstrate that uric acid induces triglyceride accumulation by SREBP-1c activation via induction of endoplasmic reticulum (ER) stress in hepatocytes. Uric Acid 25-34 sterol regulatory element binding transcription factor 1 Homo sapiens 72-80
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 heat shock protein family A (Hsp70) member 5 Homo sapiens 82-87
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 X-box binding protein 1 Homo sapiens 109-132
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 X-box binding protein 1 Homo sapiens 134-139
25302081-9 2014 Interestingly, the present study provided data suggesting that the minor A-allele of PPARGC1A (rs8192678) had a protective effect against T2DM in subjects with higher level of UA (ORint =1.50 95% CI: 1.06-2.12 for allele and P = 0.02, ORint =1.63 95% CI: 1.17-2.26 for genotype and P = 0.004). Uric Acid 176-178 PPARG coactivator 1 alpha Homo sapiens 85-93
24257692-6 2014 Additional potentially beneficial effects of SGLT2 inhibition include modest reductions in blood pressure and plasma uric acid. Uric Acid 117-126 solute carrier family 5 member 2 Homo sapiens 45-50
24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 63-79 NLR family pyrin domain containing 3 Homo sapiens 18-23
24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 63-79 interleukin 1 beta Homo sapiens 139-146
24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 81-84 NLR family pyrin domain containing 3 Homo sapiens 18-23
24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 81-84 interleukin 1 beta Homo sapiens 139-146
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 165-198
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 200-204
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 sterol regulatory element binding transcription factor 1 Homo sapiens 202-210
25111690-6 2014 A blocker of ER stress, tauroursodeoxycholic acid (TUDCA), and an inhibitor of SREBP-1c, metformin, blocked hepatic fat accumulation, suggesting that uric acid promoted fat synthesis in hepatocytes via ER stress-induced activation of SREBP-1c. Uric Acid 150-159 sterol regulatory element binding transcription factor 1 Homo sapiens 79-87
25111690-6 2014 A blocker of ER stress, tauroursodeoxycholic acid (TUDCA), and an inhibitor of SREBP-1c, metformin, blocked hepatic fat accumulation, suggesting that uric acid promoted fat synthesis in hepatocytes via ER stress-induced activation of SREBP-1c. Uric Acid 150-159 sterol regulatory element binding transcription factor 1 Homo sapiens 234-242
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 eukaryotic translation initiation factor 2A Homo sapiens 211-258
24723238-1 2014 URAT1 and GLUT9 are two primary urate transporters involved in the renal urate handling. Uric Acid 32-37 solute carrier family 22 member 12 Homo sapiens 0-5
25111690-4 2014 Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78/94), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2alpha (eIF-2alpha) in cultured hepatocytes. Uric Acid 0-9 eukaryotic translation initiation factor 2A Homo sapiens 260-270
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 acetyl-CoA carboxylase alpha Homo sapiens 87-111
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 acetyl-CoA carboxylase alpha Homo sapiens 113-117
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 fatty acid synthase Homo sapiens 120-139
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 fatty acid synthase Homo sapiens 141-144
25111690-5 2014 Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. Uric Acid 0-9 stearoyl-CoA desaturase Homo sapiens 151-176
25060549-2 2014 Polymorphisms in VDR and ZNF365 genes have been associated to calcium and uric acid lithiasis, respectively. Uric Acid 74-83 vitamin D receptor Homo sapiens 17-20
25060549-2 2014 Polymorphisms in VDR and ZNF365 genes have been associated to calcium and uric acid lithiasis, respectively. Uric Acid 74-83 zinc finger protein 365 Homo sapiens 25-31
25268603-1 2014 OBJECTIVE: Using European descent Czech populations, we performed a study of SLC2A9 and SLC22A12 genes previously identified as being associated with serum uric acid concentrations and gout. Uric Acid 156-165 solute carrier family 2 member 9 Homo sapiens 77-83
25268603-1 2014 OBJECTIVE: Using European descent Czech populations, we performed a study of SLC2A9 and SLC22A12 genes previously identified as being associated with serum uric acid concentrations and gout. Uric Acid 156-165 solute carrier family 22 member 12 Homo sapiens 88-96
25261974-8 2014 Induction of IL-1beta by MSU was fully inhibited by a caspase-1 inhibitor confirming inflammasome activation as the mechanism for generating this cytokine. Uric Acid 25-28 interleukin 1 beta Homo sapiens 13-21
25261974-8 2014 Induction of IL-1beta by MSU was fully inhibited by a caspase-1 inhibitor confirming inflammasome activation as the mechanism for generating this cytokine. Uric Acid 25-28 caspase 1 Homo sapiens 54-63
24910235-0 2014 Brief report: Granulocyte-macrophage colony-stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model. Uric Acid 70-98 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 14-62
24910235-1 2014 OBJECTIVE: To determine the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the differentiation of inflammatory macrophages in an in vivo model of monosodium urate monohydrate (MSU) crystal-induced inflammation. Uric Acid 168-196 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 36-84
24910235-1 2014 OBJECTIVE: To determine the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the differentiation of inflammatory macrophages in an in vivo model of monosodium urate monohydrate (MSU) crystal-induced inflammation. Uric Acid 168-196 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 86-92
24910235-1 2014 OBJECTIVE: To determine the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the differentiation of inflammatory macrophages in an in vivo model of monosodium urate monohydrate (MSU) crystal-induced inflammation. Uric Acid 198-201 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 36-84
25194446-8 2014 Statistically significant positive correlation was observed between uric acid and cystatin C, urea, creatinine, absolute CD4 and CD8 count. Uric Acid 68-77 cystatin C Homo sapiens 82-92
25194446-8 2014 Statistically significant positive correlation was observed between uric acid and cystatin C, urea, creatinine, absolute CD4 and CD8 count. Uric Acid 68-77 CD4 molecule Homo sapiens 121-124
25194446-8 2014 Statistically significant positive correlation was observed between uric acid and cystatin C, urea, creatinine, absolute CD4 and CD8 count. Uric Acid 68-77 CD8a molecule Homo sapiens 129-132
24723238-1 2014 URAT1 and GLUT9 are two primary urate transporters involved in the renal urate handling. Uric Acid 32-37 solute carrier family 2 member 9 Homo sapiens 10-15
24723238-3 2014 The aim of this study was to investigate the clinical features and possible impact of protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis. Uric Acid 158-167 solute carrier family 22 member 12 Homo sapiens 108-113
24723238-3 2014 The aim of this study was to investigate the clinical features and possible impact of protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis. Uric Acid 158-167 solute carrier family 2 member 9 Homo sapiens 118-123
25197023-9 2014 GGT levels were also positively correlated with the number of plaques; presence of noncalcified plaques; and levels of high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c, uric acid, and triglycerides. Uric Acid 181-190 gamma-glutamyltransferase 1 Homo sapiens 0-3
24723238-3 2014 The aim of this study was to investigate the clinical features and possible impact of protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis. Uric Acid 169-171 solute carrier family 22 member 12 Homo sapiens 108-113
24723238-3 2014 The aim of this study was to investigate the clinical features and possible impact of protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis. Uric Acid 169-171 solute carrier family 2 member 9 Homo sapiens 118-123
25146479-1 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81
24760192-8 2014 The hyperresponse of TLR2 may be secondary to the high serum urate concentration of 0.92 mmol/l that was initially found in circulation in vivo. Uric Acid 61-66 toll like receptor 2 Homo sapiens 21-25
25146480-1 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81
24608218-6 2014 SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values. Uric Acid 121-123 superoxide dismutase 1 Homo sapiens 0-3
25194401-3 2014 Recently, much attention has been made toward the prognostic implication of serum uric acid in patients with IgAN. Uric Acid 82-91 IGAN1 Homo sapiens 109-113
25128519-8 2014 The C allele of NPT1 rs1165196 was only significantly associated with gout in patients with normal uric acid excretion. Uric Acid 99-108 solute carrier family 17 member 1 Homo sapiens 16-20
25027494-11 2014 At high doses of LED-UVA (>800 kJ m(-2)), levels of phosphorylated H2AvD (gamma-H2AvD) increased significantly in the urate-null strain. Uric Acid 121-126 Histone H2A variant Drosophila melanogaster 70-75
25027494-11 2014 At high doses of LED-UVA (>800 kJ m(-2)), levels of phosphorylated H2AvD (gamma-H2AvD) increased significantly in the urate-null strain. Uric Acid 121-126 Histone H2A variant Drosophila melanogaster 77-88
24913885-3 2014 Under the optimal conditions, MWCNs/MGF/GCE can simultaneously detect AA, DA, UA and TRP with high selectivity and sensitivity. Uric Acid 78-80 aminomethyltransferase Homo sapiens 40-43
24925478-0 2014 Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret. Uric Acid 0-9 dipeptidyl peptidase 4 Homo sapiens 24-47
32261661-6 2014 Moreover, NP-PdCr shows good anti-interference toward ascorbic acid, uric acid, and dopamine after coating excess Nafion solution. Uric Acid 69-78 2,4-dienoyl-CoA reductase 2 Homo sapiens 13-17
24928513-5 2014 We now demonstrate that urate is a good substrate for bovine LPO. Uric Acid 24-29 lactoperoxidase Bos taurus 61-64
24928513-6 2014 Urate was oxidized by LPO to produce the electrophilic intermediates dehydrourate and 5-hydroxyisourate, which decayed to allantoin. Uric Acid 0-5 lactoperoxidase Homo sapiens 22-25
24928513-9 2014 During urate oxidation, LPO was diverted from its peroxidase cycle because hydrogen peroxide reacted with compound II to give compound III. Uric Acid 7-12 lactoperoxidase Homo sapiens 24-27
24928513-10 2014 At physiologically relevant concentrations, urate competed effectively with thiocyanate, the main substrate of LPO for oxidation, and inhibited production of hypothiocyanite. Uric Acid 44-49 lactoperoxidase Homo sapiens 111-114
24928513-14 2014 Our findings establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites. Uric Acid 23-28 lactoperoxidase Homo sapiens 69-72
24925478-6 2014 Increasing or decreasing intracellular peroxynitrite levels enhanced or decreased the ability of uric acid to inhibit cell associated CD26/DPPIV, respectively. Uric Acid 97-106 dipeptidyl peptidase 4 Homo sapiens 134-138
24925478-6 2014 Increasing or decreasing intracellular peroxynitrite levels enhanced or decreased the ability of uric acid to inhibit cell associated CD26/DPPIV, respectively. Uric Acid 97-106 dipeptidyl peptidase 4 Homo sapiens 139-144
24573389-0 2014 Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric acid-induced mesangial cell proliferation. Uric Acid 82-91 mitogen activated protein kinase 3 Rattus norvegicus 14-20
24573389-4 2014 UA dose dependently stimulated MC proliferation as shown by increased DNA synthesis and number of cells in the S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1. Uric Acid 0-2 cyclin A2 Rattus norvegicus 164-173
24573389-4 2014 UA dose dependently stimulated MC proliferation as shown by increased DNA synthesis and number of cells in the S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1. Uric Acid 0-2 cyclin D1 Rattus norvegicus 178-187
24573389-5 2014 In addition, UA time dependently promoted MC proliferation and significantly increased phosphorylation of ERK1/2 but not c-Jun NH2-terminal kinase and p38 MAPK in MCs as assessed by immunoblotting. Uric Acid 13-15 mitogen activated protein kinase 3 Rattus norvegicus 106-112
24573389-6 2014 Inhibition of ERK1/2 signaling via U0126 markedly blocked UA-induced MC proliferation. Uric Acid 58-60 mitogen activated protein kinase 3 Rattus norvegicus 14-20
24573389-10 2014 In conclusion, UA-induced MC proliferation was mediated by NADPH/ROS/ERK1/2 signaling pathway. Uric Acid 15-17 mitogen activated protein kinase 3 Rattus norvegicus 69-75
24928513-0 2014 Uric acid and thiocyanate as competing substrates of lactoperoxidase. Uric Acid 0-9 lactoperoxidase Homo sapiens 53-68
24813355-8 2014 There was a positive relationship between serum MCP-1 and uric acid concentrations (r = 0.27, p < 0.05). Uric Acid 58-67 C-C motif chemokine ligand 2 Homo sapiens 48-53
24755741-0 2014 Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 141-148
24755741-5 2014 The mechanism whereby AMPD controls AMPK activation depends on the production of a specific AMP downstream metabolite through AMPD, uric acid. Uric Acid 132-141 adenosine monophosphate deaminase 1 Homo sapiens 22-26
24925478-3 2014 Since EPC mobilization is dependent on activity of the enzyme CD26/dipeptidyl peptidase (DPP)IV, we examined the effect uric acid will have on CD26/DPPIV activity. Uric Acid 120-129 dipeptidyl peptidase 4 Homo sapiens 143-147
24925478-3 2014 Since EPC mobilization is dependent on activity of the enzyme CD26/dipeptidyl peptidase (DPP)IV, we examined the effect uric acid will have on CD26/DPPIV activity. Uric Acid 120-129 dipeptidyl peptidase 4 Homo sapiens 148-153
24925478-4 2014 Uric acid inhibited the CD26/DPPIV associated with human umbilical vein endothelial cells but not human recombinant (hr) CD26/DPPIV. Uric Acid 0-9 dipeptidyl peptidase 4 Homo sapiens 24-28
24925478-4 2014 Uric acid inhibited the CD26/DPPIV associated with human umbilical vein endothelial cells but not human recombinant (hr) CD26/DPPIV. Uric Acid 0-9 dipeptidyl peptidase 4 Homo sapiens 29-34
24755741-5 2014 The mechanism whereby AMPD controls AMPK activation depends on the production of a specific AMP downstream metabolite through AMPD, uric acid. Uric Acid 132-141 adenosine monophosphate deaminase 1 Homo sapiens 126-130
24755741-6 2014 In this regard, humans have higher uric acid levels than most mammals due to a mutation in uricase, the enzyme involved in uric acid degradation in most mammals, that developed during a period of famine in Europe 1.5 x 10(7) yr ago. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 91-98
25007794-0 2014 Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations. Uric Acid 64-73 solute carrier family 2 member 9 Homo sapiens 31-37
24755741-6 2014 In this regard, humans have higher uric acid levels than most mammals due to a mutation in uricase, the enzyme involved in uric acid degradation in most mammals, that developed during a period of famine in Europe 1.5 x 10(7) yr ago. Uric Acid 123-132 urate oxidase (pseudogene) Homo sapiens 91-98
24755741-8 2014 These studies identify a key role AMPD and uric acid in mediating hepatic gluconeogenesis in the diabetic state, via a mechanism involving AMPK down-regulation and overexpression of PEPCK and G6Pc. Uric Acid 43-52 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 182-187
24755741-8 2014 These studies identify a key role AMPD and uric acid in mediating hepatic gluconeogenesis in the diabetic state, via a mechanism involving AMPK down-regulation and overexpression of PEPCK and G6Pc. Uric Acid 43-52 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 192-196
24374974-7 2014 We show that Diap2 could be regulating ion channels, as loss of Diap2 consequently reduces the expression of ion channels and affects the balance of ion concentrations which results in reduced uric acid deposition. Uric Acid 193-202 Death-associated inhibitor of apoptosis 2 Drosophila melanogaster 13-18
24374974-7 2014 We show that Diap2 could be regulating ion channels, as loss of Diap2 consequently reduces the expression of ion channels and affects the balance of ion concentrations which results in reduced uric acid deposition. Uric Acid 193-202 Death-associated inhibitor of apoptosis 2 Drosophila melanogaster 64-69
24934285-0 2014 Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. Uric Acid 15-24 angiotensinogen Homo sapiens 44-59
24934285-1 2014 This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension. Uric Acid 63-72 angiotensinogen Homo sapiens 83-98
24934285-8 2014 Furthermore, it was demonstrated that obesity x uric acid was an independent contributor to angiotensinogen (beta=0.257, P<.001). Uric Acid 48-57 angiotensinogen Homo sapiens 92-107
24805955-0 2014 A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study. Uric Acid 50-59 selenium binding protein 1 Homo sapiens 83-86
24805955-2 2014 Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans. Uric Acid 76-85 solute carrier family 2 member 9 Homo sapiens 0-21
24805955-2 2014 Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans. Uric Acid 76-85 solute carrier family 2 member 9 Homo sapiens 23-28
24805955-3 2014 Since polymorphisms are randomly distributed at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded assessment of the nature of the link between uric acid and hypertension. Uric Acid 189-198 solute carrier family 2 member 9 Homo sapiens 99-104
25222164-10 2014 Serum uric acid correlated with both sFlt-1 (r = 0.65, P = 0.003) and sFlt-1/PlGF ratio (r = 0.54, P = 0.02). Uric Acid 6-15 placental growth factor Homo sapiens 77-81
25741042-1 2014 The genome-wide association study identified associations between the LRP2 polymorphism rs2544390 and serum uric acid (SUA) levels in a Japanese population. Uric Acid 108-117 LDL receptor related protein 2 Homo sapiens 70-74
24817661-7 2014 At 18-20 weeks, Pkd1(+/-) showed slightly but significantly higher urinary uric acid vs. controls while cystic animals did not. Uric Acid 75-84 polycystin 1, transient receptor potential channel interacting Mus musculus 16-20
25076422-7 2014 Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Uric Acid 275-284 clusterin Homo sapiens 46-55
25007794-9 2014 Our findings suggests a novel, non-coding regulatory mechanism for SLC2A9-mediated modulation of serum uric acid, and detail a bioinformatic approach for assessing the contribution of CNPs to heritable traits in large population-based studies where technical sources of variation are substantial. Uric Acid 103-112 solute carrier family 2 member 9 Homo sapiens 67-73
25007794-5 2014 CNPs upstream of the urate transporter SLC2A9 on chromosome 4p16.1 are associated with uric acid (chi2df2=3545, p=3.19x10-23). Uric Acid 87-96 solute carrier family 2 member 9 Homo sapiens 39-45
25007794-6 2014 Effect sizes, expressed as the percentage change in uric acid per deleted copy, are most pronounced among women (3.974.935.87 [ 2.55097.5 denoting percentiles], p=4.57x10-23) and independent of previously reported SNPs in SLC2A9 as assessed by SNP and CNP regression models and the phasing SNP and CNP haplotypes (chi2df2=3190,p=7.23x10-08). Uric Acid 52-61 solute carrier family 2 member 9 Homo sapiens 222-228
25007794-6 2014 Effect sizes, expressed as the percentage change in uric acid per deleted copy, are most pronounced among women (3.974.935.87 [ 2.55097.5 denoting percentiles], p=4.57x10-23) and independent of previously reported SNPs in SLC2A9 as assessed by SNP and CNP regression models and the phasing SNP and CNP haplotypes (chi2df2=3190,p=7.23x10-08). Uric Acid 52-61 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 252-255
25007794-6 2014 Effect sizes, expressed as the percentage change in uric acid per deleted copy, are most pronounced among women (3.974.935.87 [ 2.55097.5 denoting percentiles], p=4.57x10-23) and independent of previously reported SNPs in SLC2A9 as assessed by SNP and CNP regression models and the phasing SNP and CNP haplotypes (chi2df2=3190,p=7.23x10-08). Uric Acid 52-61 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 298-301
24443793-1 2014 AIMS: Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, has been shown to lower glycated hemoglobin (HbA1c), weight, blood pressure and serum uric acid in clinical trials. Uric Acid 160-169 solute carrier family 5 member 2 Homo sapiens 23-53
25005084-4 2014 UOX was co-crystallized with azide (N3) in the presence or absence of either uric acid (UA, the natural substrate) or 8-azaxanthine (8AZA, a competitive inhibitor). Uric Acid 88-90 urate oxidase (pseudogene) Homo sapiens 0-3
25005084-5 2014 In a second set of experiments, previously grown orthorhombic crystals of the UOX-UA or UOX-8AZA complexes were soaked in sodium azide solutions. Uric Acid 82-84 urate oxidase (pseudogene) Homo sapiens 78-81
24443793-1 2014 AIMS: Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, has been shown to lower glycated hemoglobin (HbA1c), weight, blood pressure and serum uric acid in clinical trials. Uric Acid 160-169 solute carrier family 5 member 2 Homo sapiens 55-61
24301058-0 2014 Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. Uric Acid 63-72 solute carrier family 2 member 9 Homo sapiens 29-35
24301058-2 2014 The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux across the renal proximal tubule. Uric Acid 96-101 solute carrier family 2 member 9 Homo sapiens 4-45
24301058-2 2014 The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux across the renal proximal tubule. Uric Acid 96-101 solute carrier family 2 member 9 Homo sapiens 47-53
25050113-5 2014 Western blotting assays were also performed to assess the effect of luteolin on the expression of MafA and inducible NO synthase (iNOS) in uric acid-treated cells. Uric Acid 139-148 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) Mus musculus 98-102
24518569-12 2014 Thus, an elevation in plasma CORT was consistently associated with a decrease in plasma uric acid, but not with a change in glycemia. Uric Acid 88-97 cortistatin Homo sapiens 29-33
24652948-5 2014 Suppression of eNOS phosphorylation and NO production by uric acid was PI3K/Akt-dependent, as verified by the transfection with p110. Uric Acid 57-66 AKT serine/threonine kinase 1 Rattus norvegicus 76-79
25237581-1 2014 BACKGROUND: Multiple population-based human studies have established a strong association between increasing levels of serum C-reactive protein, uric acid and subsequent development of hypertension. Uric Acid 145-154 C-reactive protein Homo sapiens 125-143
25050113-5 2014 Western blotting assays were also performed to assess the effect of luteolin on the expression of MafA and inducible NO synthase (iNOS) in uric acid-treated cells. Uric Acid 139-148 nitric oxide synthase 2, inducible Mus musculus 107-128
25050113-5 2014 Western blotting assays were also performed to assess the effect of luteolin on the expression of MafA and inducible NO synthase (iNOS) in uric acid-treated cells. Uric Acid 139-148 nitric oxide synthase 2, inducible Mus musculus 130-134
25050113-7 2014 We found that luteolin significantly inhibited uric acid-induced NO production, which was well correlated with reduced expression of iNOS mRNA and protein. Uric Acid 47-56 nitric oxide synthase 2, inducible Mus musculus 133-137
25050113-8 2014 Furthermore, decreased activity of NF-kappaB was implicated in inhibition by luteolin of increased iNOS expression induced by uric acid. Uric Acid 126-135 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 35-44
25050113-8 2014 Furthermore, decreased activity of NF-kappaB was implicated in inhibition by luteolin of increased iNOS expression induced by uric acid. Uric Acid 126-135 nitric oxide synthase 2, inducible Mus musculus 99-103
25050113-9 2014 Besides, luteolin significantly increased MafA expression in Min6 cells exposed to uric acid, which was reversed by overexpression of iNOS. Uric Acid 83-92 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) Mus musculus 42-46
25050113-9 2014 Besides, luteolin significantly increased MafA expression in Min6 cells exposed to uric acid, which was reversed by overexpression of iNOS. Uric Acid 83-92 nitric oxide synthase 2, inducible Mus musculus 134-138
25052714-0 2014 Uric acid accumulation in an Arabidopsis urate oxidase mutant impairs seedling establishment by blocking peroxisome maintenance. Uric Acid 0-9 uricase / urate oxidase / nodulin 35 Arabidopsis thaliana 41-54
25052714-2 2014 We have isolated a urate oxidase (uox) mutant of Arabidopsis thaliana that accumulates uric acid in all tissues, especially in the developing embryo. Uric Acid 87-96 uricase / urate oxidase / nodulin 35 Arabidopsis thaliana 19-32
25052714-4 2014 The uox mutant phenotype is suppressed in a xanthine dehydrogenase (xdh) uox double mutant, demonstrating that the underlying cause is not the defective purine base catabolism, or the lack of UOX per se, but the elevated uric acid concentration in the embryo. Uric Acid 221-230 uricase / urate oxidase / nodulin 35 Arabidopsis thaliana 4-7
25052714-8 2014 The peroxisomal defect explains the developmental phenotypes of the uox mutant, drawing a novel link between uric acid and peroxisome function, which may be relevant beyond plants. Uric Acid 109-118 uricase / urate oxidase / nodulin 35 Arabidopsis thaliana 68-71
25052714-2 2014 We have isolated a urate oxidase (uox) mutant of Arabidopsis thaliana that accumulates uric acid in all tissues, especially in the developing embryo. Uric Acid 87-96 uricase / urate oxidase / nodulin 35 Arabidopsis thaliana 34-37
26328161-0 2014 The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats. Uric Acid 38-47 erythropoietin Rattus norvegicus 14-28
24742479-2 2014 The rs734553 single-nucleotide polymorphism (SNP) of the GLUT9 urate transporter gene was strongly associated with uric acid (UA) levels in a large meta-analysis. Uric Acid 115-124 solute carrier family 2 member 9 Homo sapiens 57-62
24742479-2 2014 The rs734553 single-nucleotide polymorphism (SNP) of the GLUT9 urate transporter gene was strongly associated with uric acid (UA) levels in a large meta-analysis. Uric Acid 126-128 solute carrier family 2 member 9 Homo sapiens 57-62
24742479-11 2014 CONCLUSIONS: A GLUT9 polymorphism, which is strongly associated with serum UA levels in healthy individuals of the general population with normal renal function, holds a strong predictive power for CKD progression. Uric Acid 75-77 solute carrier family 2 member 9 Homo sapiens 15-20
24685936-12 2014 Uric acid in the TFG (1.57 +- 0.23 mg/dL) was significantly lower than in the NTFG (2.34 +- 0.20mg/dL) and the CG (3.49 +- 0.21 mg/dL). Uric Acid 0-9 trafficking from ER to golgi regulator Homo sapiens 17-20
25126408-3 2014 This has led to the development of novel agents to inhibit sodium glucose transporter-2 (SGLT2) as a means to better control glucose levels and at the same time augment calorie wasting and lower insulin, blood pressure and uric acid levels. Uric Acid 223-232 solute carrier family 5 member 2 Homo sapiens 59-87
25126408-3 2014 This has led to the development of novel agents to inhibit sodium glucose transporter-2 (SGLT2) as a means to better control glucose levels and at the same time augment calorie wasting and lower insulin, blood pressure and uric acid levels. Uric Acid 223-232 solute carrier family 5 member 2 Homo sapiens 89-94
25137848-0 2014 [Effect of compound qingqin liquid on the expression levels of ang II and COX-2 mRNA transcription and protein expression in the renal tissue of uric acid nephropathy rats: an experimental study]. Uric Acid 145-154 angiotensinogen Rattus norvegicus 63-69
25137848-0 2014 [Effect of compound qingqin liquid on the expression levels of ang II and COX-2 mRNA transcription and protein expression in the renal tissue of uric acid nephropathy rats: an experimental study]. Uric Acid 145-154 cytochrome c oxidase II, mitochondrial Rattus norvegicus 74-79
25137848-1 2014 OBJECTIVE: To investigate the effect of Compound Qingqin Liquid (CQL) on the expression level of angiotensin II (Ang II) and COX-2 mRNA transcription and protein expression in the renal tissue of rats with uric acid nephropathy. Uric Acid 206-215 angiotensinogen Rattus norvegicus 97-111
24959672-0 2014 Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity. Uric Acid 61-66 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4
24959672-5 2014 Moreover, urate induced NF-E2-related factor 2 (Nrf2) accumulation by inhibiting its ubiquitinationa and degradation, and also promoted its nuclear translocation; however, it did not modulate Nrf2 mRNA level or Kelch-like ECH-associated protein 1 (Keap1) expression. Uric Acid 10-15 NFE2 like bZIP transcription factor 2 Homo sapiens 24-46
24959672-5 2014 Moreover, urate induced NF-E2-related factor 2 (Nrf2) accumulation by inhibiting its ubiquitinationa and degradation, and also promoted its nuclear translocation; however, it did not modulate Nrf2 mRNA level or Kelch-like ECH-associated protein 1 (Keap1) expression. Uric Acid 10-15 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52
24959672-5 2014 Moreover, urate induced NF-E2-related factor 2 (Nrf2) accumulation by inhibiting its ubiquitinationa and degradation, and also promoted its nuclear translocation; however, it did not modulate Nrf2 mRNA level or Kelch-like ECH-associated protein 1 (Keap1) expression. Uric Acid 10-15 kelch like ECH associated protein 1 Homo sapiens 211-246
24959672-5 2014 Moreover, urate induced NF-E2-related factor 2 (Nrf2) accumulation by inhibiting its ubiquitinationa and degradation, and also promoted its nuclear translocation; however, it did not modulate Nrf2 mRNA level or Kelch-like ECH-associated protein 1 (Keap1) expression. Uric Acid 10-15 kelch like ECH associated protein 1 Homo sapiens 248-253
24959672-6 2014 In addition, urate markedly up-regulated the transcription and protein expression of gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC) and heme oxygenase-1 (HO-1), both of which are controlled by Nrf2 activity. Uric Acid 13-18 heme oxygenase 1 Homo sapiens 152-168
24959672-6 2014 In addition, urate markedly up-regulated the transcription and protein expression of gamma-glutamate-cysteine ligase catalytic subunit (gamma-GCLC) and heme oxygenase-1 (HO-1), both of which are controlled by Nrf2 activity. Uric Acid 13-18 NFE2 like bZIP transcription factor 2 Homo sapiens 209-213
24959672-7 2014 Furthermore, Nrf2 knockdown by siRNA abolished the intracellular glutathione augmentation and the protection exerted by urate pretreatment. Uric Acid 120-125 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17
24959672-8 2014 CONCLUSION: Our findings demonstrated that urate treatment may result in Nrf2-targeted anti-oxidant genes transcription and expression by reducing Nrf2 ubiquitination and degradation and promoting its nuclear translocation, and thus offer neuroprotection on dopaminergic cells against oxidative stresses. Uric Acid 43-48 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77
24959672-8 2014 CONCLUSION: Our findings demonstrated that urate treatment may result in Nrf2-targeted anti-oxidant genes transcription and expression by reducing Nrf2 ubiquitination and degradation and promoting its nuclear translocation, and thus offer neuroprotection on dopaminergic cells against oxidative stresses. Uric Acid 43-48 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151
24795458-0 2014 S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes. Uric Acid 11-20 interleukin 10 Homo sapiens 67-72
24795458-0 2014 S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes. Uric Acid 11-20 indoleamine 2,3-dioxygenase 1 Homo sapiens 74-77
24587486-1 2014 OBJECTIVE: Evidence for the role of autophagy in the regulation of inflammation, especially IL-1b expression in response to monosodium urate (MSU) crystals, is presented. Uric Acid 124-140 interleukin 1 beta Homo sapiens 92-97
24587486-1 2014 OBJECTIVE: Evidence for the role of autophagy in the regulation of inflammation, especially IL-1b expression in response to monosodium urate (MSU) crystals, is presented. Uric Acid 142-145 interleukin 1 beta Homo sapiens 92-97
24619560-10 2014 Urate crystals were detected most frequently in MTP1 joints (DECT 20/78, US 58/78), any other toe joints (DECT 25/78, US 62/78) and knees (DECT 41/78, US 31/78). Uric Acid 0-5 solute carrier family 40 member 1 Homo sapiens 48-52
26328161-5 2014 RESULTS: 1) Erythropoietin administration non-significantly decreased the serum uric acid levels non-significantly by 0.02 mg/dL [-0.2415423 mg/dL-0.2015423 mg/dL] (p=0.8560), in accordance with the paired t-test (p=0.8438). Uric Acid 80-89 erythropoietin Rattus norvegicus 12-26
26328161-7 2014 3) The interaction of erythropoietin administration and reperfusion time non-significantly increased the serum uric acid levels non-significantly by 0.1 mg/dL [-0.0295564 mg/dL-0.2295564 mg/dL] (p=0.1264). Uric Acid 111-120 erythropoietin Rattus norvegicus 22-36
24844637-2 2014 Clinically, increased serum urate levels are indicative of pregnancy-induced hypertension (PIH). Uric Acid 28-33 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 91-94
24503762-0 2014 Uric acid and allograft loss from interstitial fibrosis/tubular atrophy: post hoc analysis from the angiotensin II blockade in chronic allograft nephropathy trial. Uric Acid 0-9 angiotensinogen Homo sapiens 100-114
24857923-2 2014 Genetic variations in the ABCG2 gene have been reported to influence serum uric acid levels and to participate in the pathogenesis of gout, but no further data have been reported in the Han Chinese population. Uric Acid 75-84 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 26-31
24441542-5 2014 The voltammetric response of AA was well resolved from the responses of DA and UA, and the oxidation potential of AA was negatively shifted to -0.20 V. The biosensor tolerated a wide linear concentration range for AA, from 1.0 x 10(-5)M to 2.63 x 10(-3)M (R(2)=0.9929), with a detection limit of 0.5 muM (S/N = 3). Uric Acid 79-81 latexin Homo sapiens 300-303
24362079-3 2014 The obtained results demonstrate that nitrogen doping in ZnO matrix offers a striking electrocatalytic activity to the immobilized uricase towards the oxidation of analyte (uric acid) and promotes the direct transfer of electrons from active sites of enzyme onto the electrode without any mediator. Uric Acid 173-182 urate oxidase (pseudogene) Homo sapiens 131-138
24769205-0 2014 High uric acid directly inhibits insulin signalling and induces insulin resistance. Uric Acid 5-14 insulin Homo sapiens 33-40
24769205-0 2014 High uric acid directly inhibits insulin signalling and induces insulin resistance. Uric Acid 5-14 insulin Homo sapiens 64-71
24769205-2 2014 However, how high uric acid (HUA) level causes insulin resistance remains unclear. Uric Acid 18-27 insulin Homo sapiens 47-54
24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 insulin receptor substrate 1 Mus musculus 38-42
24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 thymoma viral proto-oncogene 1 Mus musculus 47-50
24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 insulin Homo sapiens 51-58
24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 insulin Homo sapiens 81-88
24833923-3 2014 It has been reported that the antihypertensive drug, irbesartan, inhibits the renal uric acid reabsorptive transporters, URAT1 and GLUT9; this result suggests that irbesartan decreases serum uric acid level (SUA). Uric Acid 84-93 solute carrier family 22 member 12 Homo sapiens 121-126
24827988-9 2014 Moderate wine drinking did not increase serum uric acid concentrations, and the urate transporter ABCG2, unlike MTHFR, was a genetic determinant of serum uric acid concentrations. Uric Acid 154-163 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 98-103
24680743-2 2014 Allopurinol, an inhibitor of xanthine oxidoreductase (XOR), blocks the oxidation of xanthine to urate. Uric Acid 96-101 xanthine dehydrogenase Mus musculus 29-52
24680743-2 2014 Allopurinol, an inhibitor of xanthine oxidoreductase (XOR), blocks the oxidation of xanthine to urate. Uric Acid 96-101 xanthine dehydrogenase Mus musculus 54-57
24663677-5 2014 Importantly, upon exposure to proteases, uric acid (UA) was rapidly released into the airway lumen, and removal of this endogenous UA by uricase prevented type 2 immune responses. Uric Acid 131-133 urate oxidase Mus musculus 137-144
24470119-1 2014 OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout. Uric Acid 11-39 interleukin 1 beta Homo sapiens 62-79
24470119-1 2014 OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout. Uric Acid 11-39 interleukin 1 beta Homo sapiens 81-89
24470119-1 2014 OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout. Uric Acid 41-44 interleukin 1 beta Homo sapiens 62-79
24470119-1 2014 OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout. Uric Acid 41-44 interleukin 1 beta Homo sapiens 81-89
24530799-2 2014 PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid. Uric Acid 111-120 purine nucleoside phosphorylase Tursiops truncatus 0-3
24829966-9 2014 Serum uric acid was related to age, male gender, hypertension, smoking, renal failure (p < 0.001), previous coronary artery bypass grafts (p = 0.05), therapy with ACE inhibitors (p = 0.001) and diuretics (p < 0.001), glycaemia (p = 0.001), creatinine (p < 0.001), haemoglobin (p = 0.002) and white blood cells (p = 0.02). Uric Acid 6-15 angiotensin I converting enzyme Homo sapiens 166-169
24663677-6 2014 UA promoted secretion of IL-33 by airway epithelial cells in vitro, and administration of UA into the airways of naive animals induced extracellular release of IL-33, followed by both innate and adaptive type 2 immune responses in vivo. Uric Acid 0-2 interleukin 33 Mus musculus 25-30
24663677-6 2014 UA promoted secretion of IL-33 by airway epithelial cells in vitro, and administration of UA into the airways of naive animals induced extracellular release of IL-33, followed by both innate and adaptive type 2 immune responses in vivo. Uric Acid 90-92 interleukin 33 Mus musculus 160-165
24782985-2 2014 OVs induce mostly immunogenic cancer cell death (ICD), including immunogenic apoptosis, necrosis/necroptosis, pyroptosis, and autophagic cell death, leading to exposure of calreticulin and heat-shock proteins to the cell surface, and/or released ATP, high-mobility group box 1, uric acid, and other damage-associated molecular patterns as well as pathogen-associated molecular patterns as danger signals, along with tumor-associated antigens, to activate dendritic cells and elicit adaptive antitumor immunity. Uric Acid 278-287 calreticulin Homo sapiens 172-184
24689969-9 2014 Compared with patients with YKL-40 below the ROC-derived cut-off point (24.5 ng/mL), the high YKL-40 group showed higher pulmonary vascular resistance and serum uric acid levels, and showed more clinical worsening events and deaths in Kaplan-Meier analyses. Uric Acid 161-170 chitinase 3 like 1 Homo sapiens 94-100
24750032-6 2014 The detection limit for these electrodes is around 10 muM DA in mixtures with uric acid, ascorbic acid, and cetaminophen, decreasing to 2-3 muM in the absence of such interferents. Uric Acid 78-87 latexin Homo sapiens 54-57
24418684-6 2014 Uric acid level was associated with diabetes even after adjustment for risk factors (per 1 mg/dL, hazard ratio = 1.18, 95% confidence interval: 1.13, 1.23), and the association remained significant after adjustment for fasting glucose and insulin levels. Uric Acid 0-9 insulin Homo sapiens 239-246
23799920-1 2014 OBJECTIVE: Serum uric acid levels have been reported to be associated with metabolic syndrome (MetS). Uric Acid 17-26 ETS variant transcription factor 3 Homo sapiens 95-99
23799920-2 2014 However, few studies specifically examining the relationship between serum uric acid (SUA) levels and MetS in postmenopausal women have been reported in China. Uric Acid 75-84 ETS variant transcription factor 3 Homo sapiens 102-106
23799920-11 2014 The prevalence of MetS increased gradually with an increasing serum uric acid quartile (p for trend < 0.001). Uric Acid 68-77 ETS variant transcription factor 3 Homo sapiens 18-22
24366390-1 2014 A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Uric Acid 91-100 LDL receptor related protein 2 Homo sapiens 192-196
24366390-1 2014 A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Uric Acid 91-100 LDL receptor related protein 2 Homo sapiens 197-204
24366390-3 2014 Although no studies report that LRP2 transports urate, LRP2 is a multi-ligand receptor and expresses in many tissues including kidney, suggesting a direct and/or indirect relationship with gout. Uric Acid 48-53 LDL receptor related protein 2 Homo sapiens 32-36
24656042-3 2014 (2014) demonstrates that Clec12a is a receptor for dead cells through the recognition of uric acid crystals and contributes to the dampening of the responses. Uric Acid 89-98 C-type lectin domain family 12 member A Homo sapiens 25-32
24140872-5 2014 By simultaneously changing the concentrations of AA, DA and UA, their oxidation peaks appeared at -0.05 V, 0.16 V and 2.6 V, and the good linear responses ranges were 73.52-2305.53 muM, 1.36-125.69 muM and 3.98-371.49 muM, respectively. Uric Acid 60-62 latexin Homo sapiens 181-184
24140872-5 2014 By simultaneously changing the concentrations of AA, DA and UA, their oxidation peaks appeared at -0.05 V, 0.16 V and 2.6 V, and the good linear responses ranges were 73.52-2305.53 muM, 1.36-125.69 muM and 3.98-371.49 muM, respectively. Uric Acid 60-62 latexin Homo sapiens 198-201
24140872-5 2014 By simultaneously changing the concentrations of AA, DA and UA, their oxidation peaks appeared at -0.05 V, 0.16 V and 2.6 V, and the good linear responses ranges were 73.52-2305.53 muM, 1.36-125.69 muM and 3.98-371.49 muM, respectively. Uric Acid 60-62 latexin Homo sapiens 198-201
24679039-0 2014 Serum uric acid can predict higher C-reactive protein levels in apparently healthy men. Uric Acid 6-15 C-reactive protein Homo sapiens 35-53
24679039-9 2014 CONCLUSION: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. Uric Acid 16-25 fibrinogen beta chain Homo sapiens 145-166
24631154-0 2014 Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Uric Acid 38-47 C-type lectin domain family 12, member a Mus musculus 0-7
24631154-4 2014 Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Uric Acid 52-61 C-type lectin domain family 12, member a Mus musculus 21-28
24631154-4 2014 Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Uric Acid 52-61 male sterility and urinary obstruction Mus musculus 90-93
24631154-4 2014 Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Uric Acid 72-88 C-type lectin domain family 12, member a Mus musculus 21-28
24568660-3 2014 In this study, uric acid is shown to be an efficient precursor to formation of CNCl and NCl3. Uric Acid 15-24 calpain 5 Homo sapiens 88-92
24628802-3 2014 CASE PRESENTATION: Herein, we report the case of a girl with severe iRHUC (serum urate 0.05 mg/dL, fractional excretion of uric acid 295.99%) associated with recurrent EIAKI, in whom the disease was caused by a homozygous mutation (g.68G > A in exon 3) in the SLC2A9 gene. Uric Acid 81-86 solute carrier family 2 member 9 Homo sapiens 263-269
24235082-6 2014 Multiple logistic regression analysis revealed a significant association between lipocalin 2 and soluble tumor necrosis factor receptor 2 (sTNF-R2), eGFR and uric acid in general subjects attending regular annual medical check-up (n = 420). Uric Acid 158-167 lipocalin 2 Homo sapiens 81-92
24627417-5 2014 For each 1-SD increase in serum urate, the serum CRP concentration was 20% higher in unadjusted linear regression models and 13% higher in multivariable linear regression models, after accounting for the effects of age, sex, race, socioeconomic and educational strata, renal function, lipids, smoking, and body mass index. Uric Acid 32-37 C-reactive protein Homo sapiens 49-52
24445479-4 2014 Better understanding of the transporters URAT1 and ABCG2 in particular would appear to provide opportunities for more selective, better tolerated agents to increase the renal clearance of uric acid and thereby control hyperuricemia. Uric Acid 188-197 solute carrier family 22 member 12 Homo sapiens 41-46
24445479-4 2014 Better understanding of the transporters URAT1 and ABCG2 in particular would appear to provide opportunities for more selective, better tolerated agents to increase the renal clearance of uric acid and thereby control hyperuricemia. Uric Acid 188-197 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 51-56
24451032-1 2014 The role of interleukin-1 (IL-1) in inflammation induced by crystals, and especially by monosodium urate crystals (MSUCs), has raised much interest in both basic and clinical investigation. Uric Acid 88-104 interleukin 1 alpha Homo sapiens 12-25
24451032-1 2014 The role of interleukin-1 (IL-1) in inflammation induced by crystals, and especially by monosodium urate crystals (MSUCs), has raised much interest in both basic and clinical investigation. Uric Acid 88-104 interleukin 1 alpha Homo sapiens 27-31
24550457-2 2014 Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Uric Acid 103-112 urate oxidase (pseudogene) Homo sapiens 11-18
24353177-0 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81
24353177-2 2014 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2alpha) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure). Uric Acid 58-67 insulin Homo sapiens 334-341
24353177-2 2014 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2alpha) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure). Uric Acid 69-71 insulin Homo sapiens 334-341
24949036-12 2014 With respect to metabolic parameters, the patients in the higher UA quartiles exhibited higher levels of body mass index (BMI), SBP, FBG and triglycerides (TG). Uric Acid 65-67 selenium binding protein 1 Homo sapiens 128-131
24433899-4 2014 Under the optimized conditions, the peak currents increased linearly with the concentration of UA in the range from 0.60 to 100.0 muM, with a detection limit of 0.13 muM. Uric Acid 95-97 latexin Homo sapiens 130-133
24433899-4 2014 Under the optimized conditions, the peak currents increased linearly with the concentration of UA in the range from 0.60 to 100.0 muM, with a detection limit of 0.13 muM. Uric Acid 95-97 latexin Homo sapiens 166-169
24235082-7 2014 When subjects with diabetes were excluded from the analysis, lipocalin 2 remained associated with sTNF-R2, eGFR and uric acid. Uric Acid 116-125 lipocalin 2 Homo sapiens 61-72
24036988-5 2014 Furthermore, moderate positive correlations were observed between concentration of uric acid and the TLR4 mRNA level, serum IL1beta production (r = 0.649, 0.616), and strong positive correlation was observed between TLR4 mRNA level and serum IL1beta (r = 0.848) in 52 AGA patients. Uric Acid 83-92 toll like receptor 4 Homo sapiens 101-105
24318630-9 2014 Serum uric acid level was positively and significantly associated with lumbar spine BMD independent of age, body mass index, smoking, drinking, physical activity, years after menopause, diabetes mellitus, hypertension, serum calcium, estimated glomerular filtration rate, plasma C-reactive protein, and serum alkaline phosphatase (standardized beta = 0.078, p = 0.049). Uric Acid 6-15 C-reactive protein Homo sapiens 279-329
24396852-0 2014 Effect of processing parameters for electrocatalytic properties of SnO(2) thin film matrix for uric acid biosensor. Uric Acid 95-104 strawberry notch homolog 2 Homo sapiens 67-70
24513273-11 2014 The minor allele (T) for rs11722228 in SLC2A9 has greater influence in elevating serum UA levels in females compared to males and the minor allele (T) of rs2231142 in ABCG2 had stronger effects on serum UA levels in males than that in females. Uric Acid 87-89 solute carrier family 2 member 9 Homo sapiens 39-45
24513273-11 2014 The minor allele (T) for rs11722228 in SLC2A9 has greater influence in elevating serum UA levels in females compared to males and the minor allele (T) of rs2231142 in ABCG2 had stronger effects on serum UA levels in males than that in females. Uric Acid 87-89 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 167-172
24513273-11 2014 The minor allele (T) for rs11722228 in SLC2A9 has greater influence in elevating serum UA levels in females compared to males and the minor allele (T) of rs2231142 in ABCG2 had stronger effects on serum UA levels in males than that in females. Uric Acid 203-205 solute carrier family 2 member 9 Homo sapiens 39-45
24513273-11 2014 The minor allele (T) for rs11722228 in SLC2A9 has greater influence in elevating serum UA levels in females compared to males and the minor allele (T) of rs2231142 in ABCG2 had stronger effects on serum UA levels in males than that in females. Uric Acid 203-205 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 167-172
24513273-12 2014 CONCLUSIONS: Two genetic loci (SLC2A9 and ABCG2) were confirmed to be associated with serum UA concentration. Uric Acid 92-94 solute carrier family 2 member 9 Homo sapiens 31-37
24513273-12 2014 CONCLUSIONS: Two genetic loci (SLC2A9 and ABCG2) were confirmed to be associated with serum UA concentration. Uric Acid 92-94 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 42-47
24513273-13 2014 These findings strongly support the evidence that SLC2A9 and ABCG2 function in UA metabolism across human populations. Uric Acid 79-81 solute carrier family 2 member 9 Homo sapiens 50-56
24513273-13 2014 These findings strongly support the evidence that SLC2A9 and ABCG2 function in UA metabolism across human populations. Uric Acid 79-81 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 61-66
24357442-7 2014 Further, we have revealed that xanthine oxidoreductase, the enzyme that catalyses the production of uric acid, is present at elevated levels in wound fluid. Uric Acid 100-109 xanthine dehydrogenase Homo sapiens 31-54
24375010-9 2014 CONCLUSIONS: In summary, higher serum copeptin levels, a surrogate for arginine vasopressin (AVP) release, are associated not only with systolic and diastolic blood pressure but also with several components of metabolic syndrome including obesity, elevated concentration of triglycerides, albuminuria, and serum uric acid level. Uric Acid 312-321 arginine vasopressin Homo sapiens 38-46
24550911-5 2014 Over the last few years, it has been reported that HZ, similar to uric acid crystals, asbestos, and silica, is able to trigger IL-1beta production via the activation of the NOD-like receptor containing pyrin domain 3 (NLRP3) inflammasome complex. Uric Acid 66-75 interleukin 1 beta Homo sapiens 127-135
23968597-6 2014 The RESMENA group exhibited a significant decrease in alanine aminotransferase and aspartate aminotransferase (AST) concentrations ( - 26 8%; P= 0 008 and - 14 0%; P= 0 018, respectively), while the Control group exhibited a significant increase in glucose (7 9%; P= 0 011), AST (11 3%; P= 0 045) and uric acid (9 0%; P< 0 001) concentrations. Uric Acid 301-310 solute carrier family 17 member 5 Homo sapiens 111-114
23584883-14 2014 The fact that serum UA did not increase despite the decrease in UA excretion suggests that an excretory pathway other than the kidney, probably the intestine, may operate in a complementary role that corroborates the increase in ABCG2 expression in the ileum. Uric Acid 20-22 ATP binding cassette subfamily G member 2 Rattus norvegicus 229-234
24287205-10 2014 Furthermore, decreasing SBP by up regulation of NOS-1 expression and down regulation of TNF-alpha and TGF-beta1 expression are involved in the effect of IGPS on high uric acid-induced nephropathy. Uric Acid 166-175 tumor necrosis factor Rattus norvegicus 88-97
24287205-10 2014 Furthermore, decreasing SBP by up regulation of NOS-1 expression and down regulation of TNF-alpha and TGF-beta1 expression are involved in the effect of IGPS on high uric acid-induced nephropathy. Uric Acid 166-175 transforming growth factor, beta 1 Rattus norvegicus 102-111
24036988-5 2014 Furthermore, moderate positive correlations were observed between concentration of uric acid and the TLR4 mRNA level, serum IL1beta production (r = 0.649, 0.616), and strong positive correlation was observed between TLR4 mRNA level and serum IL1beta (r = 0.848) in 52 AGA patients. Uric Acid 83-92 interleukin 1 beta Homo sapiens 124-131
24036988-5 2014 Furthermore, moderate positive correlations were observed between concentration of uric acid and the TLR4 mRNA level, serum IL1beta production (r = 0.649, 0.616), and strong positive correlation was observed between TLR4 mRNA level and serum IL1beta (r = 0.848) in 52 AGA patients. Uric Acid 83-92 interleukin 1 beta Homo sapiens 242-249
24476385-0 2014 Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge. Uric Acid 49-54 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 17-22
24498153-1 2014 BACKGROUND: Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. Uric Acid 162-171 xanthine dehydrogenase Bos taurus 12-35
24498153-1 2014 BACKGROUND: Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. Uric Acid 162-171 xanthine dehydrogenase Bos taurus 37-40
24498153-1 2014 BACKGROUND: Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. Uric Acid 162-171 xanthine dehydrogenase Bos taurus 82-104
24498153-1 2014 BACKGROUND: Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. Uric Acid 162-171 xanthine dehydrogenase Bos taurus 106-109
23852697-0 2014 Population-specific effects of SLC17A1 genotype on serum urate concentrations and renal excretion of uric acid during a fructose load. Uric Acid 57-62 solute carrier family 17 member 1 Homo sapiens 31-38
24423013-0 2014 Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy. Uric Acid 7-16 CD79a molecule Homo sapiens 81-84
24423013-9 2014 We also found that in the subgroup of 258 IgAN cases with normal baseline eGFR (eGFR > =90 ml/min/1.73 M2), higher plasma uric acid associated with more severe tubulointerstitial lesions with Beijing scoring system (P = 3.4*10-5). Uric Acid 125-134 IGAN1 Homo sapiens 42-46
24423013-9 2014 We also found that in the subgroup of 258 IgAN cases with normal baseline eGFR (eGFR > =90 ml/min/1.73 M2), higher plasma uric acid associated with more severe tubulointerstitial lesions with Beijing scoring system (P = 3.4*10-5). Uric Acid 125-134 epidermal growth factor receptor Homo sapiens 74-78
24423013-9 2014 We also found that in the subgroup of 258 IgAN cases with normal baseline eGFR (eGFR > =90 ml/min/1.73 M2), higher plasma uric acid associated with more severe tubulointerstitial lesions with Beijing scoring system (P = 3.4*10-5). Uric Acid 125-134 epidermal growth factor receptor Homo sapiens 80-84
24423013-14 2014 CONCLUSIONS: Plasma uric acid levels indicate tubular interstitial lesions in IgAN and hyperuricemia may be considered as a marker for tubulointerstitial lesions. Uric Acid 20-29 IGAN1 Homo sapiens 78-82
24409316-2 2014 URATv1), as one of the most influential genes for serum urate levels. Uric Acid 56-61 solute carrier family 2 member 9 Homo sapiens 0-6
24409316-14 2014 CONCLUSIONS/SIGNIFICANCE: SLC2A9-L was expressed in the basolateral membrane of kidney proximal tubules in humans and this isoform is likely to responsible for urate reabsorption. Uric Acid 160-165 solute carrier family 2 member 9 Homo sapiens 26-32
23869629-11 2014 Significant negative correlations between uric acid and CTX I and between MMP-8 and uric acid have been found. Uric Acid 84-93 matrix metallopeptidase 8 Homo sapiens 74-79
24489966-8 2014 Furthermore, serum CXCL16 concentration negatively correlated with estimated glomerular filtrate rate, creatinine clearance rate and blood albumin, and positively with 24 h proteinuria, blood urea nitrogen (BUN), creatinine, and uric acid after adjusting for age, gender and BMI in subjects with DN. Uric Acid 229-238 C-X-C motif chemokine ligand 16 Homo sapiens 19-25
24717661-0 2014 Covalent immobilization of uricase inside a plastic vial for uric acid determination in serum and urine. Uric Acid 61-70 urate oxidase (pseudogene) Homo sapiens 27-34
24717661-3 2014 There was a linear relationship between the immobilized uricase activity and the uric acid concentration in the range of 0.01 to 1.2 mM with an apparent Km for uric acid of 0.17 mM. Uric Acid 81-90 urate oxidase (pseudogene) Homo sapiens 56-63
24717661-3 2014 There was a linear relationship between the immobilized uricase activity and the uric acid concentration in the range of 0.01 to 1.2 mM with an apparent Km for uric acid of 0.17 mM. Uric Acid 160-169 urate oxidase (pseudogene) Homo sapiens 56-63
25136576-3 2014 In all, we identified 13 novel mutations in Saudi Arabian HPRT-related hyperuricemia patients manifesting different levels of uric acid. Uric Acid 126-135 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 58-62
24422572-6 2014 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Uric Acid 63-79 NLR family pyrin domain containing 3 Homo sapiens 132-137
24422572-6 2014 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Uric Acid 63-79 interleukin 1 beta Homo sapiens 180-188
24422572-6 2014 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Uric Acid 63-79 interleukin 1 beta Homo sapiens 180-184
25451835-1 2014 Uric acid and arteriosclerosis in apolipoprotein e-deficient mice. Uric Acid 0-9 apolipoprotein E Mus musculus 34-50
24158515-1 2014 OBJECTIVE: Xanthine oxidoreductase (XOR) catalyzes the production of uric acid with concomitant generation of reactive oxygen species. Uric Acid 69-78 xanthine dehydrogenase Mus musculus 11-34
24158515-1 2014 OBJECTIVE: Xanthine oxidoreductase (XOR) catalyzes the production of uric acid with concomitant generation of reactive oxygen species. Uric Acid 69-78 xanthine dehydrogenase Mus musculus 36-39
24877124-3 2014 Uric acid and xanthine oxidase may contribute to kidney fibrosis mainly by inducing inflammation, endothelial dysfunction, oxidative stress, and activation of the renin-angiotensin system. Uric Acid 0-9 renin Homo sapiens 163-168
25116356-1 2014 BACKGROUND/AIMS: Uric acid nephrolithiasis is prevalent among patients with type 2 diabetes and metabolic syndrome; it is correlated with an acidic urine and lower urinary ammonium excretion and is likely associated with insulin resistance. Uric Acid 17-26 insulin Homo sapiens 221-228
24377830-6 2014 Addition of exogenous uric acid increased the influx of heterophils into rabbit intestinal loops, as measured by myeloperoxidase activity. Uric Acid 22-31 myeloperoxidase Oryctolagus cuniculus 113-128
25401709-10 2014 In vitro experiments, we found that high concentrations of uric acid reduced catalase expression in endothelial cells, which was alleviated by Smilacis Glabrae Rhizoma and resulted in a reduction of reactive oxygen species. Uric Acid 59-68 catalase Rattus norvegicus 77-85
25185415-2 2014 Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. Uric Acid 80-89 xanthine dehydrogenase Homo sapiens 0-23
25185415-2 2014 Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. Uric Acid 80-89 xanthine dehydrogenase Homo sapiens 25-28
24025986-4 2014 Since human organic anion transporter 4 (OAT4/SLC22A11) is expressed in the kidney and mediates urate transport, we investigated the effects of a common variant of OAT4/SLC22A11 on the susceptibility to gout. Uric Acid 96-101 solute carrier family 22 member 11 Homo sapiens 12-39
24025986-4 2014 Since human organic anion transporter 4 (OAT4/SLC22A11) is expressed in the kidney and mediates urate transport, we investigated the effects of a common variant of OAT4/SLC22A11 on the susceptibility to gout. Uric Acid 96-101 solute carrier family 22 member 11 Homo sapiens 41-45
24025986-4 2014 Since human organic anion transporter 4 (OAT4/SLC22A11) is expressed in the kidney and mediates urate transport, we investigated the effects of a common variant of OAT4/SLC22A11 on the susceptibility to gout. Uric Acid 96-101 solute carrier family 22 member 11 Homo sapiens 46-54
24869748-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a xenobiotic transporter and also regulates serum uric acid levels as a urate transporter. Uric Acid 123-132 ATP binding cassette subfamily A member 4 Homo sapiens 0-56
24869748-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a xenobiotic transporter and also regulates serum uric acid levels as a urate transporter. Uric Acid 123-132 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 58-63
24869748-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a xenobiotic transporter and also regulates serum uric acid levels as a urate transporter. Uric Acid 123-132 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 64-68
23645404-0 2014 Serum uric acid as a predictor of mortality and future exacerbations of COPD. Uric Acid 6-15 COPD Homo sapiens 72-76
24318514-2 2014 Recently, genome-wide association studies revealed an association between serum uric acid levels and a common variant of leucine-rich repeat-containing 16A (LRRC16A) gene. Uric Acid 80-89 capping protein regulator and myosin 1 linker 1 Homo sapiens 121-155
24318514-2 2014 Recently, genome-wide association studies revealed an association between serum uric acid levels and a common variant of leucine-rich repeat-containing 16A (LRRC16A) gene. Uric Acid 80-89 capping protein regulator and myosin 1 linker 1 Homo sapiens 157-164
24318514-11 2014 We have shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure. Uric Acid 101-106 capping protein regulator and myosin 1 linker 1 Homo sapiens 38-44
24318514-11 2014 We have shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure. Uric Acid 101-106 capping protein regulator and myosin 1 linker 1 Homo sapiens 45-52
24372653-5 2014 The third quintile of uric acid levels (357-405 muM) had the lowest mortality risk and was used as reference group. Uric Acid 22-31 latexin Homo sapiens 48-51
24372653-6 2014 In Cox proportional hazard models adjusting for graft and patient characteristics, the fifth quintile of uric acid levels (>474 muM) was independently associated with cardiovascular mortality (hazard ratio [HR] = 2.87 [1.55-5.32], p = 0.001) and all-cause mortality (HR = 1.57 [1.09-2.25], p = 0.02). Uric Acid 105-114 latexin Homo sapiens 131-134
24372653-7 2014 Also, the lowest quintile of uric acid levels (<309 muM) showed a trend toward increased risk of cardiovascular mortality (HR = 1.79 [0.90-3.58], p = 0.10) and all-cause mortality (HR = 1.31 [0.89-1.93], p = 0.18). Uric Acid 29-38 latexin Homo sapiens 55-58
24356095-0 2014 Effects of uric acid levels on outcome in severe ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator. Uric Acid 11-20 chromosome 20 open reading frame 181 Homo sapiens 111-139
25328755-8 2014 This study identifies a role for PAF and the PAF receptor antagonist in the pathway by which macrophages ingest MSU crystals and resolve the concomitant inflammation. Uric Acid 112-115 PCNA clamp associated factor Homo sapiens 33-36
24999366-0 2014 Effects of Modified Simiao Decoction on IL-1 beta and TNF alpha Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation. Uric Acid 104-120 tumor necrosis factor Homo sapiens 54-63
25101126-2 2014 LNS is characterized by a decrease in activity of hypoxanthine guanine phosphoribosyl transferase, an enzyme involved in purine metabolism, resulting in overproduction of uric acid. Uric Acid 171-180 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 50-97
25328755-8 2014 This study identifies a role for PAF and the PAF receptor antagonist in the pathway by which macrophages ingest MSU crystals and resolve the concomitant inflammation. Uric Acid 112-115 PCNA clamp associated factor Homo sapiens 45-48
24999366-2 2014 The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 beta and TNF alpha secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation. Uric Acid 151-167 interleukin 1 beta Homo sapiens 87-96
25102750-12 2014 There was a positive correlation between Lp-PLA2 activity and TG, uric acid and negative correlation between Lp-PLA2 activity and HDL-C levels. Uric Acid 66-75 phospholipase A2 group VII Homo sapiens 41-48
24999366-2 2014 The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 beta and TNF alpha secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation. Uric Acid 151-167 tumor necrosis factor Homo sapiens 101-110
24999366-2 2014 The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 beta and TNF alpha secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation. Uric Acid 169-172 interleukin 1 beta Homo sapiens 87-96
24696812-1 2014 The uric acid biosensor has been much developed by immobilizing uricase enzyme into the membrane of conductive polymer and the membrane of polyelectrolyte such as polyaniline (PANI) and poly (allylamine) (PAA) respectively. Uric Acid 4-13 urate oxidase (pseudogene) Homo sapiens 64-71
24696812-2 2014 The purpose of this research was to create a new amperometric uric acid biosensor by immobilization of uricase in combination between PANI and PAA membranes. Uric Acid 62-71 urate oxidase (pseudogene) Homo sapiens 103-110
24772444-3 2014 We then assessed whether LPD influences uric acid metabolism and benefits the progression of DN in streptozotocin- (STZ-) induced diabetic rats. Uric Acid 40-49 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 25-28
24772444-12 2014 CONCLUSION: LPD inhibits endogenous uric acid synthesis and might accordingly attenuate renal damage in STZ-induced diabetic rats. Uric Acid 36-45 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 12-15
24309486-1 2014 OBJECTIVE: Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. Uric Acid 17-26 insulin Homo sapiens 193-200
24940679-5 2014 The export process by mouse Abcg2 was ATP-dependent and not saturable under the physiological concentration of urate. Uric Acid 111-116 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 28-33
24940669-8 2014 This "false in vitro elevation" of UA levels in mouse blood after blood sampling was inhibited by allopurinol, a xanthine oxidase inhibitor. Uric Acid 35-37 xanthine dehydrogenase Mus musculus 113-129
24269076-8 2014 Finally, to evaluate the potential implications of these findings in humans, the association between uric acid and PTH in humans was evaluated in a cross-sectional analysis of data from the NHANES (2003-2006); n = 9773. Uric Acid 101-110 parathyroid hormone Homo sapiens 115-118
24269076-18 2014 The association between uric acid and PTH in NHANES suggests potential implications for human disease. Uric Acid 24-33 parathyroid hormone Homo sapiens 38-41
24972010-1 2014 Glut9 is highly expressed in the human kidney proximal convoluted tubular and plays a crucial role in the regulation of plasma urate levels. Uric Acid 127-132 solute carrier family 2 member 9 Homo sapiens 0-5
24940669-9 2014 Xanthine oxidase was converted to UA in mouse serum from hypoxanthine which was released from blood cells during incubation. Uric Acid 34-36 xanthine dehydrogenase Mus musculus 0-16
24940679-13 2014 Accordingly, increased SUA in patients with ABCG2 dysfunction could be explained by the decreased excretion of urate from the intestine. Uric Acid 111-116 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 44-49
24940677-12 2014 R380W is a dysfunctional mutation which completely diminishes the urate transport activities of GLUT9. Uric Acid 66-71 solute carrier family 2 member 9 Homo sapiens 96-101
23273711-0 2014 ESR1 gene and insulin resistance remission are associated with serum uric acid decline for severely obese patients undergoing bariatric surgery. Uric Acid 69-78 estrogen receptor 1 Homo sapiens 0-4
24940678-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels and gout/hyperuricemia risk. Uric Acid 169-178 ATP binding cassette subfamily A member 4 Homo sapiens 0-56
24940678-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels and gout/hyperuricemia risk. Uric Acid 169-178 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 58-63
24940678-1 2014 ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels and gout/hyperuricemia risk. Uric Acid 169-178 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 64-68
24940678-3 2014 In this study, we investigated the effects of ABCG2 dysfunction on human urate handling and the mechanism of hyperuricemia. Uric Acid 73-78 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 46-51
24940679-0 2014 ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion. Uric Acid 34-43 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-5
24940679-1 2014 ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified as a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels and gout/hyperuricemia risk. Uric Acid 198-207 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-35
24940679-1 2014 ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified as a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels and gout/hyperuricemia risk. Uric Acid 198-207 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 37-42
24940679-1 2014 ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified as a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels and gout/hyperuricemia risk. Uric Acid 198-207 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 59-91
24940679-1 2014 ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified as a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels and gout/hyperuricemia risk. Uric Acid 198-207 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 93-97
24940679-3 2014 In this study, we investigated how ABCG2 dysfunction affected the urate excretion pathways. Uric Acid 66-71 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 35-40
24940679-4 2014 First, we revealed that mouse Abcg2 mediates urate transport using the membrane vesicle system. Uric Acid 45-50 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 30-35
24338552-4 2014 It effectively restored renal protein level alterations of urate transport-related molecular proteins urate transporter 1, glucose transporter 9, organic anion transporter 1, and ATP-binding cassette subfamily G member 2 in this model, possibly resulting in the enhancement of kidney urate excretion. Uric Acid 59-64 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 102-173
25178483-7 2014 From the population study, apoA-I was increasingly associated with normouricaemia, hyperuricaemia, and acute gouty arthritis (ptrend < 0.001), and plasma uric acid (UA) and apoA-I were positively correlated (p = 0.0156). Uric Acid 157-166 apolipoprotein A1 Homo sapiens 27-33
25178483-7 2014 From the population study, apoA-I was increasingly associated with normouricaemia, hyperuricaemia, and acute gouty arthritis (ptrend < 0.001), and plasma uric acid (UA) and apoA-I were positively correlated (p = 0.0156). Uric Acid 168-170 apolipoprotein A1 Homo sapiens 27-33
25178483-8 2014 We used a human liver cell model and found that UA enhanced the hepatic apoA-I mRNA expression level (ptrend < 0.01) and apoA-I secretion level (ptrend = 0.002) in a dose-dependent manner. Uric Acid 48-50 apolipoprotein A1 Homo sapiens 72-78
25178483-8 2014 We used a human liver cell model and found that UA enhanced the hepatic apoA-I mRNA expression level (ptrend < 0.01) and apoA-I secretion level (ptrend = 0.002) in a dose-dependent manner. Uric Acid 48-50 apolipoprotein A1 Homo sapiens 124-130
25178483-10 2014 CONCLUSIONS: Based on the role of apoA-I in anti-inflammation, our observational data in acute gout support the hypothesis that apoA-I expression can be induced under the condition of a high concentration of UA and its elevated level may be implicated in the spontaneous resolution of acute gouty arthritis. Uric Acid 208-210 apolipoprotein A1 Homo sapiens 34-40
25178483-10 2014 CONCLUSIONS: Based on the role of apoA-I in anti-inflammation, our observational data in acute gout support the hypothesis that apoA-I expression can be induced under the condition of a high concentration of UA and its elevated level may be implicated in the spontaneous resolution of acute gouty arthritis. Uric Acid 208-210 apolipoprotein A1 Homo sapiens 128-134
23273711-0 2014 ESR1 gene and insulin resistance remission are associated with serum uric acid decline for severely obese patients undergoing bariatric surgery. Uric Acid 69-78 insulin Homo sapiens 14-21
23273711-3 2014 The aim of our study was to determine the relationships between serum uric acid reduction and estrogen receptor-alpha (ESR1) gene polymorphism, as well as the type of bariatric surgery received. Uric Acid 70-79 estrogen receptor 1 Homo sapiens 94-117
23273711-3 2014 The aim of our study was to determine the relationships between serum uric acid reduction and estrogen receptor-alpha (ESR1) gene polymorphism, as well as the type of bariatric surgery received. Uric Acid 70-79 estrogen receptor 1 Homo sapiens 119-123
23273711-7 2014 A 12-month follow-up was performed to explore the effects of the type of bariatric surgery and ESR1 polymorphism on serum uric acid reduction. Uric Acid 122-131 estrogen receptor 1 Homo sapiens 95-99
23273711-8 2014 RESULTS: The rs712221 polymorphism of ESR1 affects serum uric acid reduction after bariatric surgery. Uric Acid 57-66 estrogen receptor 1 Homo sapiens 38-42
23273711-12 2014 CONCLUSIONS: For severely obese Han Chinese patients, bariatric surgery appears to reduce serum uric acid levels, potentially mediated by synergic effects of surgery type, BMI reduction, rs712221 locus, insulin sensitivity, and changed dietary factors via an unknown mechanism. Uric Acid 96-105 insulin Homo sapiens 203-210
24379826-0 2013 Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Uric Acid 91-100 solute carrier family 2 member 9 Homo sapiens 73-79
24655968-12 2014 Univariate logistic regression revealed the following variables to be associated with serum leptin level: metabolic syndrome, sex, body weight, waist circumference, body mass index (BMI), hypertension, serum creatinine, fasting blood sugar, HbA1c, serum triglyceride, and uric acid. Uric Acid 272-281 leptin Homo sapiens 92-98
24507048-0 2014 Fibroblast growth factor-23 levels are associated with uric acid but not carotid intima media thickness in renal transplant recipients. Uric Acid 55-64 fibroblast growth factor 23 Homo sapiens 0-27
24507048-11 2014 WC, creatinine, and uric acid were positively correlated with FGF-23, whereas albumin showed negative correlation. Uric Acid 20-29 fibroblast growth factor 23 Homo sapiens 62-68
24507048-12 2014 On multivariate analysis only creatinine and uric acid were determinants of FGF-23. Uric Acid 45-54 fibroblast growth factor 23 Homo sapiens 76-82
24507048-13 2014 CONCLUSION: FGF-23 levels are associated with uric acid in RTR. Uric Acid 46-55 fibroblast growth factor 23 Homo sapiens 12-18
24330812-7 2013 Fully adjusted Cox regression analyses showed that per 1 SD (87 mumol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). Uric Acid 91-100 cytochrome c oxidase subunit 8A Homo sapiens 15-18
24344940-9 2013 There was a significant positive correlation between mean uric acid concentrations, and both serum creatinine (P = .000; r=0.487) and cystatin C (P = .000; r=0.433). Uric Acid 58-67 cystatin C Homo sapiens 134-144
24330409-8 2013 In separate models, urate levels at baseline (RR 1 mg/dL increase = 2.33, 95% CI: 1.94-2.80) and 3 years after baseline (RR for a 1 mg/dL increase = 1.92, 95% CI: 1.78-2.07) were associated with incident hyperuricemia after accounting for demographic and clinical risk factors. Uric Acid 20-25 ribonucleotide reductase catalytic subunit M1 Homo sapiens 46-50
24340056-2 2013 Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown. Uric Acid 85-87 parathyroid hormone Homo sapiens 16-35
24340056-2 2013 Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown. Uric Acid 187-189 parathyroid hormone Homo sapiens 16-35
24344940-11 2013 Mean uric acid levels of patients with intact graft function (estimated glomerular filtration rate >= 60 mL/min/1.73 m2) was lower than the patients with a low estimated glomerular filtration rate (291 +- 67 mumol/L and 353 +- 71 mumol/L; P = .000). Uric Acid 5-14 CD59 molecule (CD59 blood group) Homo sapiens 111-116
23786870-1 2013 OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction. Uric Acid 129-145 interleukin 1 beta Homo sapiens 207-224
23990105-4 2013 Although the function of MCT9 remains unclear, urate is mostly excreted via intestine and kidney where MCT9 expression is observed. Uric Acid 47-52 solute carrier family 16 member 9 Homo sapiens 103-107
24051131-8 2013 There were positive correlations between Hsp70 levels and TNF-alpha, TNFRI, IL-1beta, IL-12, GOT, GPT, LDH, and uric acid concentrations in early-onset PE group. Uric Acid 112-121 heat shock protein family A (Hsp70) member 4 Homo sapiens 41-46
23644878-11 2013 The serum UA levels were inversely related to both serum C-terminal telopeptide of type I collagen and osteocalcin levels (p < 0.001 and p = 0.004, respectively). Uric Acid 10-12 bone gamma-carboxyglutamate protein Homo sapiens 103-114
23786870-1 2013 OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction. Uric Acid 129-145 interleukin 1 beta Homo sapiens 226-234
23786870-1 2013 OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction. Uric Acid 147-150 interleukin 1 beta Homo sapiens 207-224
23786870-1 2013 OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction. Uric Acid 147-150 interleukin 1 beta Homo sapiens 226-234
24045866-1 2013 Plasma levels of uric acid, the final product of purine degradation in humans, are elevated in metabolic syndrome and are strongly associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD). Uric Acid 17-26 insulin Homo sapiens 147-154
24555241-6 2013 The explanation of these findings would be that the stimulation of MRP1- and MRP2-mediated transport of glutathione conjugates of toxic substances may have slight beneficial effects, while stimulation of MRP4-mediated efflux of brain urate, which has an important antioxidant potency, may worsen the effects of oxidative stress. Uric Acid 234-239 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 67-71
24555241-6 2013 The explanation of these findings would be that the stimulation of MRP1- and MRP2-mediated transport of glutathione conjugates of toxic substances may have slight beneficial effects, while stimulation of MRP4-mediated efflux of brain urate, which has an important antioxidant potency, may worsen the effects of oxidative stress. Uric Acid 234-239 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus 77-81
24555241-6 2013 The explanation of these findings would be that the stimulation of MRP1- and MRP2-mediated transport of glutathione conjugates of toxic substances may have slight beneficial effects, while stimulation of MRP4-mediated efflux of brain urate, which has an important antioxidant potency, may worsen the effects of oxidative stress. Uric Acid 234-239 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 204-208
32261059-6 2013 In addition, Nafion/Aurod@Pt/GCE was found to exhibit a low working potential, fast amperometric response, high sensitivity, good reproducibility, good long term stability, and a high specificity to glucose with negligible interference from uric acid, ascorbic acid, acetamidophenol, or chloride ions. Uric Acid 241-250 aminomethyltransferase Homo sapiens 29-32
26328123-1 2013 Xanthine dehydrogenase catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid in the final two steps of the purine degradation process. Uric Acid 91-100 xanthine dehydrogenase Homo sapiens 0-22
24045866-7 2013 Analysis of gene expression in NAFLD biopsies showed an association between mRNA expression of GCKR, the glucokinase regulatory protein that is functionally linked to uric acid production, and mRNA expression of the phosphate transporters encoded by SLC17A1/3. Uric Acid 167-176 glucokinase regulator Homo sapiens 95-99
24045866-7 2013 Analysis of gene expression in NAFLD biopsies showed an association between mRNA expression of GCKR, the glucokinase regulatory protein that is functionally linked to uric acid production, and mRNA expression of the phosphate transporters encoded by SLC17A1/3. Uric Acid 167-176 solute carrier family 17 member 1 Homo sapiens 250-257
24188743-9 2013 Compared with individuals with FPG-based diagnosis of MetS, individuals with HbA1c-based diagnosis of MetS were older, had higher levels of LDL-C, magnesium, and transferrin, and lower levels of uric acid. Uric Acid 195-204 hemoglobin subunit alpha 1 Homo sapiens 77-81
24287461-5 2013 Recent studies have shown that human ATP-binding cassette transporter ABCG2 plays a role of renal excretion of uric acid. Uric Acid 111-120 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 70-75
24286387-1 2013 INTRODUCTION: The T allele of a single nucleotide polymorphism (SNP: rs2544390) in lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk of gout in Japanese individuals. Uric Acid 161-166 LDL receptor related protein 2 Homo sapiens 83-121
24286387-1 2013 INTRODUCTION: The T allele of a single nucleotide polymorphism (SNP: rs2544390) in lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk of gout in Japanese individuals. Uric Acid 161-166 LDL receptor related protein 2 Homo sapiens 123-127
23349133-12 2013 CONCLUSIONS: Variation in SLC2A9 influences acute serum urate and FEUA responses to a fructose load. Uric Acid 56-61 solute carrier family 2 member 9 Homo sapiens 26-32
24456929-0 2013 NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts. Uric Acid 28-33 NLR family pyrin domain containing 3 Homo sapiens 0-5
23349133-4 2013 OBJECTIVE: To determine whether genetic variation in SLC2A9 influences the acute serum urate response to a fructose load. Uric Acid 87-92 solute carrier family 2 member 9 Homo sapiens 53-59
23918657-0 2013 Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents. Uric Acid 116-132 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-38
23918657-3 2013 The aim of this study was to evaluate the role of transient receptor potential ankyrin 1 (TRPA-1) and TRPA-1 stimulants, such as H2 O2 , in a rodent model of MSU-induced inflammation. Uric Acid 158-161 transient receptor potential cation channel subfamily A member 1 Homo sapiens 50-88
23918657-3 2013 The aim of this study was to evaluate the role of transient receptor potential ankyrin 1 (TRPA-1) and TRPA-1 stimulants, such as H2 O2 , in a rodent model of MSU-induced inflammation. Uric Acid 158-161 transient receptor potential cation channel subfamily A member 1 Homo sapiens 90-96
23918657-6 2013 RESULTS: TRPA-1 antagonism, TRPA-1 gene deletion, or pretreatment of peptidergic TRP-expressing primary sensory neurons with capsaicin markedly decreased MSU-induced nociception and edema. Uric Acid 154-157 transient receptor potential cation channel subfamily A member 1 Homo sapiens 9-15
23918657-6 2013 RESULTS: TRPA-1 antagonism, TRPA-1 gene deletion, or pretreatment of peptidergic TRP-expressing primary sensory neurons with capsaicin markedly decreased MSU-induced nociception and edema. Uric Acid 154-157 transient receptor potential cation channel subfamily A member 1 Homo sapiens 28-34
24456929-1 2013 INTRODUCTION: Monosodium urate (MSU) microcrystals present in bone tissues of chronic gout can be ingested by nonprofessional phagocytes like osteoblasts (OBs) that express NLRP3 (nucleotide-binding domain and leucine-rich repeat region containing family of receptor protein 3). Uric Acid 14-30 NLR family pyrin domain containing 3 Homo sapiens 173-178
24241090-6 2013 Visfatin showed significant positive correlations with low-density lipoprotein cholesterol, uric acid, blood urea nitrogen, creatinine, brain natriuretic peptide, E-selectin, total leukocyte count, neutrophil count, and high-sensitivity C-reactive protein, and a significant negative correlation with estimated glomerular filtration rate and albumin. Uric Acid 92-101 nicotinamide phosphoribosyltransferase Homo sapiens 0-8
23994369-2 2013 The enzyme xanthine oxidase (XO) produces uric acid during the purine metabolism; therefore, discovering novel XO inhibitors is an important strategy to develop an effective therapy for hyperuricemia and gout. Uric Acid 42-51 xanthine dehydrogenase Mus musculus 11-27
23994369-2 2013 The enzyme xanthine oxidase (XO) produces uric acid during the purine metabolism; therefore, discovering novel XO inhibitors is an important strategy to develop an effective therapy for hyperuricemia and gout. Uric Acid 42-51 xanthine dehydrogenase Mus musculus 29-31
23994369-2 2013 The enzyme xanthine oxidase (XO) produces uric acid during the purine metabolism; therefore, discovering novel XO inhibitors is an important strategy to develop an effective therapy for hyperuricemia and gout. Uric Acid 42-51 xanthine dehydrogenase Mus musculus 111-113
23525542-3 2013 We describe a 13-year-old boy with renal hypouricemia type 1 (serum uric acid, 0.9 mg/dL) with a homozygous W258X mutation in the SLC22A12 gene, presenting with EIAKI and PRES. Uric Acid 68-77 solute carrier family 22 member 12 Homo sapiens 130-138
24205181-8 2013 Treatment of beta-cells in vitro with uric acid activated the NF-kappaB signaling pathway through IkappaBalpha phosphorylation, resulting in upregulated inducible nitric oxide synthase (iNOS) expression and excessive nitric oxide (NO) production. Uric Acid 38-47 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 98-110
24006511-6 2013 In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate. Uric Acid 167-183 interleukin 1 beta Homo sapiens 40-48
24127597-4 2013 Recent studies indicate that the reactive oxygen species produced by mitochondrial respiration is critical for the activation of the NLRP3 inflammasome by monosodium urate, alum, and ATP. Uric Acid 155-171 NLR family pyrin domain containing 3 Homo sapiens 133-138
24205181-8 2013 Treatment of beta-cells in vitro with uric acid activated the NF-kappaB signaling pathway through IkappaBalpha phosphorylation, resulting in upregulated inducible nitric oxide synthase (iNOS) expression and excessive nitric oxide (NO) production. Uric Acid 38-47 nitric oxide synthase 2, inducible Mus musculus 153-184
24205181-8 2013 Treatment of beta-cells in vitro with uric acid activated the NF-kappaB signaling pathway through IkappaBalpha phosphorylation, resulting in upregulated inducible nitric oxide synthase (iNOS) expression and excessive nitric oxide (NO) production. Uric Acid 38-47 nitric oxide synthase 2, inducible Mus musculus 186-190
24205181-9 2013 Uric acid treatment also increased apoptosis and downregulated Bcl-2 expression in Min6 cells. Uric Acid 0-9 B cell leukemia/lymphoma 2 Mus musculus 63-68
24205181-12 2013 Further investigation indicated that uric acid suppressed levels of MafA protein through enhancing its degradation. Uric Acid 37-46 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) Mus musculus 68-72
24205181-13 2013 Collectively, our data suggested that an elevated level of uric acid causes beta-cell injury via the NF-kappaB-iNOS-NO signaling axis. Uric Acid 59-68 nitric oxide synthase 2, inducible Mus musculus 111-115
23748428-4 2013 Umod mutant mice exhibit increased plasma urea and Cystatin levels, impaired urinary concentration ability, reduced fractional excretion of uric acid and nephropathological alterations including uromodulin retention in TALH cells, interstitial fibrosis and inflammatory cell infiltrations, tubular atrophy and occasional glomerulo- und tubulocystic changes, a phenotype highly similar to UAKD in humans. Uric Acid 140-149 uromodulin Mus musculus 0-4
23651571-5 2013 By simultaneously changing the concentrations of AA, DA, UA and AC, their electrochemical oxidation peaks appeared at -0.03, 0.15, 0.24 and 0.35 V, and good linear current responses were obtained in the concentration ranges of 6-350, 0.5-50, 1-90 and 0.4-32 muM with the detection limits of 1, 0.1, 0.2 and 0.05 muM (S/N=3), respectively. Uric Acid 57-59 latexin Homo sapiens 258-261
23651571-5 2013 By simultaneously changing the concentrations of AA, DA, UA and AC, their electrochemical oxidation peaks appeared at -0.03, 0.15, 0.24 and 0.35 V, and good linear current responses were obtained in the concentration ranges of 6-350, 0.5-50, 1-90 and 0.4-32 muM with the detection limits of 1, 0.1, 0.2 and 0.05 muM (S/N=3), respectively. Uric Acid 57-59 latexin Homo sapiens 312-315
23838153-0 2013 A biohybrid hydrogel for the urate-responsive release of urate oxidase. Uric Acid 29-34 urate oxidase Mus musculus 57-70
23838153-2 2013 In this study we describe a biohybrid hydrogel that detects elevated concentrations of uric acid and responds by dissolution and the release of uric acid-degrading urate oxidase. Uric Acid 87-96 urate oxidase Mus musculus 164-177
23838153-2 2013 In this study we describe a biohybrid hydrogel that detects elevated concentrations of uric acid and responds by dissolution and the release of uric acid-degrading urate oxidase. Uric Acid 144-153 urate oxidase Mus musculus 164-177
23838153-3 2013 This material was synthesized by incorporating PEG-stabilized urate oxidase into a polyacrylamide hydrogel that was crosslinked by the uric acid-sensitive interaction between the uric acid transcription factor HucR and its operator hucO. Uric Acid 135-144 urate oxidase Mus musculus 62-75
23940049-3 2013 Ang II promotes a rapid increase in 3-nitrotyrosine formation, and uric acid attenuates Ang II-induced decrease in NO bioavailability, demonstrating that peroxynitrite mediates the effects of Ang II on eNOS dysfunction. Uric Acid 67-76 angiotensinogen Homo sapiens 88-94
23940049-3 2013 Ang II promotes a rapid increase in 3-nitrotyrosine formation, and uric acid attenuates Ang II-induced decrease in NO bioavailability, demonstrating that peroxynitrite mediates the effects of Ang II on eNOS dysfunction. Uric Acid 67-76 angiotensinogen Homo sapiens 88-94
23804456-0 2013 Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. Uric Acid 0-5 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 77-82
23665398-5 2013 A transport assay, using membrane vesicles of cells overexpressing the transporters, revealed that uric acid inhibited substrate-specific transport by BCRP at clinically relevant concentrations (calculated IC50 value: 365+-13muM), as was previously reported for MRP4. Uric Acid 99-108 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 151-155
23665398-5 2013 A transport assay, using membrane vesicles of cells overexpressing the transporters, revealed that uric acid inhibited substrate-specific transport by BCRP at clinically relevant concentrations (calculated IC50 value: 365+-13muM), as was previously reported for MRP4. Uric Acid 99-108 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 262-266
23665398-10 2013 Based on our results, we postulate that elevated uric acid levels hamper MRP4 and BCRP functioning, thereby promoting the retention of other potentially toxic substrates, including kynurenic acid, which could contribute to the development of CKD. Uric Acid 49-58 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 73-77
23665398-10 2013 Based on our results, we postulate that elevated uric acid levels hamper MRP4 and BCRP functioning, thereby promoting the retention of other potentially toxic substrates, including kynurenic acid, which could contribute to the development of CKD. Uric Acid 49-58 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 82-86
24454316-5 2013 To this point, elevated serum levels of uric acid appear to contribute to impaired nitric oxide production/endothelial dysfunction, increased vascular stiffness, inappropriate activation of the renin-angiotensin-aldosterone system, enhanced oxidative stress, and maladaptive immune and inflammatory responses. Uric Acid 40-49 renin Homo sapiens 194-199
22577128-6 2013 Significant (p < 0.001) elevation of ceruloplasmin (Cp) and C-reactive protein was associated with marked decreases in superoxide dismutase (p < 0.01), catalase (p < 0.001), and glutathione (p < 0.05) and significant (p < 0.001) increases in malondialdehyde (MDA) and uric acid when compared with control. Uric Acid 283-292 ceruloplasmin Homo sapiens 40-53
22577128-6 2013 Significant (p < 0.001) elevation of ceruloplasmin (Cp) and C-reactive protein was associated with marked decreases in superoxide dismutase (p < 0.01), catalase (p < 0.001), and glutathione (p < 0.05) and significant (p < 0.001) increases in malondialdehyde (MDA) and uric acid when compared with control. Uric Acid 283-292 C-reactive protein Homo sapiens 63-81
23980097-3 2013 In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1beta production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity. Uric Acid 131-140 NLR family, pyrin domain containing 3 Mus musculus 155-160
23980097-3 2013 In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1beta production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity. Uric Acid 131-140 interleukin 1 beta Mus musculus 183-191
23841795-5 2013 The soluble UA stimulated the upregulation of the alpha-SMA, TGF-beta1 and FN mRNA and proteins in a concentration- and time-dependent manner. Uric Acid 12-14 actin gamma 2, smooth muscle Rattus norvegicus 50-59
23841795-5 2013 The soluble UA stimulated the upregulation of the alpha-SMA, TGF-beta1 and FN mRNA and proteins in a concentration- and time-dependent manner. Uric Acid 12-14 transforming growth factor, beta 1 Rattus norvegicus 61-70
23841795-5 2013 The soluble UA stimulated the upregulation of the alpha-SMA, TGF-beta1 and FN mRNA and proteins in a concentration- and time-dependent manner. Uric Acid 12-14 fibronectin 1 Rattus norvegicus 75-77
23841795-6 2013 UA-induced endoplasmic reticulum (ER) stress, as evidenced by the upregulation of the mRNA and protein expressions of GRP78 and PDI. Uric Acid 0-2 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 118-123
23841795-6 2013 UA-induced endoplasmic reticulum (ER) stress, as evidenced by the upregulation of the mRNA and protein expressions of GRP78 and PDI. Uric Acid 0-2 prolyl 4-hydroxylase subunit beta Rattus norvegicus 128-131
23903286-8 2013 Moreover, PAI-1 11053TG+GG frequency was positively related to plasma homocysteine and urate levels, whereas -844AA frequency was associated with plasma folate concentrations according to ordinal logistic regression analysis. Uric Acid 87-92 serpin family E member 1 Homo sapiens 10-15
23913681-3 2013 Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Uric Acid 82-91 xanthine dehydrogenase Mus musculus 100-123
23913681-3 2013 Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Uric Acid 82-91 xanthine dehydrogenase Mus musculus 125-128
23913681-4 2013 Plasma uric acid was elevated in obese mice and attenuated by administration of the XOR inhibitor febuxostat. Uric Acid 7-16 xanthine dehydrogenase Mus musculus 84-87
23913681-8 2013 Surgical ischemia in adipose tissue increased local uric acid production and secretion via XOR, with a subsequent increase in circulating uric acid levels. Uric Acid 52-61 xanthine dehydrogenase Mus musculus 91-94
23804456-1 2013 Plasma urate levels are higher in humans than rodents (240-360 vs. ~30 muM) because humans lack the liver enzyme uricase. Uric Acid 7-12 latexin Homo sapiens 71-74
23804456-4 2013 We recently generated mice with liver-specific ablation of Glut9, a urate transporter providing access of urate to uricase (LG9KO mice). Uric Acid 68-73 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 59-64
23729572-1 2013 BACKGROUND: beta3-Adrenergic receptor (beta3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Uric Acid 113-122 adrenoceptor beta 3 Homo sapiens 39-47
26064845-3 2013 In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. Uric Acid 144-153 insulin Homo sapiens 9-16
23852331-3 2013 RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). Uric Acid 75-80 solute carrier family 2 member 9 Homo sapiens 17-23
23852331-3 2013 RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). Uric Acid 75-80 solute carrier family 2 member 9 Homo sapiens 24-29
23852331-3 2013 RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). Uric Acid 75-80 solute carrier family 2 member 9 Homo sapiens 31-37
23852331-3 2013 RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). Uric Acid 75-80 solute carrier family 22 member 12 Homo sapiens 166-174
23852331-5 2013 Accordingly, hypofunction of ABCG2 leads to increased fractional excretion of urate, a finding traditionally interpreted as overproduction hyperuricemia. Uric Acid 78-83 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 29-34
23852331-7 2013 OAT2 (SLC22A7) may take up urate from blood to the proximal tubular cell. Uric Acid 27-32 solute carrier family 22 member 7 Homo sapiens 0-4
23852331-7 2013 OAT2 (SLC22A7) may take up urate from blood to the proximal tubular cell. Uric Acid 27-32 solute carrier family 22 member 7 Homo sapiens 6-13
23400363-7 2013 Data indicate that hypoxanthine alters cholinesterase activities, probably through free radicals and uric acid production since the alterations were prevented by the administration of allopurinol and antioxidants. Uric Acid 101-110 butyrylcholinesterase Homo sapiens 39-53
23729572-1 2013 BACKGROUND: beta3-Adrenergic receptor (beta3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Uric Acid 113-122 adrenoceptor beta 3 Homo sapiens 12-37
23703922-4 2013 RESULTS: Significant associations were found in SLC2A9 gene SNPs and plasma uric acid levels (rs6449213, P = 3.15 x 10(-12) ). Uric Acid 76-85 solute carrier family 2 member 9 Homo sapiens 48-54
23805880-8 2013 Cox proportional-hazards multivariate models were applied for measuring hazard ratios (HRs) for diabetes according to continuous and categorical levels of uric acid. Uric Acid 155-164 cytochrome c oxidase subunit 8A Homo sapiens 0-3
23703922-7 2013 Besides SLC2A9, three previously identified uric acid-related genes ABCG2 (rs2622605, P= 0.0026), SLC17A1 (rs3799344, P = 0.0017), and RREB1 (rs1615495, P = 0.00055) received marginal support in our study. Uric Acid 44-53 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 68-73
23703922-7 2013 Besides SLC2A9, three previously identified uric acid-related genes ABCG2 (rs2622605, P= 0.0026), SLC17A1 (rs3799344, P = 0.0017), and RREB1 (rs1615495, P = 0.00055) received marginal support in our study. Uric Acid 44-53 solute carrier family 17 member 1 Homo sapiens 98-105
23703922-7 2013 Besides SLC2A9, three previously identified uric acid-related genes ABCG2 (rs2622605, P= 0.0026), SLC17A1 (rs3799344, P = 0.0017), and RREB1 (rs1615495, P = 0.00055) received marginal support in our study. Uric Acid 44-53 ras responsive element binding protein 1 Homo sapiens 135-140
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 47-56 Eph receptor B1 Rattus norvegicus 32-35
23673972-8 2013 There were positive correlations between the serum uric acid and urine NGAL/cr. Uric Acid 51-60 lipocalin 2 Homo sapiens 71-75
23673972-11 2013 In the multiple regression models, serum uric acid, systolic blood pressure and cholesterol accounted for more than 49 % of the variation in the NGAL/cr. Uric Acid 41-50 lipocalin 2 Homo sapiens 145-149
23673972-13 2013 In the second model, serum uric acid, gender, age and systolic blood pressure accounted for more than 36 % of the variation in the KIM-1/cr. Uric Acid 27-36 hepatitis A virus cellular receptor 1 Homo sapiens 131-136
22498419-9 2013 Patients in higher GGT quartiles were predominantly males (P<0.001) and were more likely to be smoking (P=0.004), and have elevated uric acid (P<0.001), fasting blood glucose (P<0.001), CRP levels (P=0.003) and 10-year total cardiovascular risk (P=0.007) and low HDL levels (P<0.001). Uric Acid 135-144 gamma-glutamyltransferase light chain family member 3 Homo sapiens 19-22
23707617-0 2013 Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic beta cells. Uric Acid 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 71-119
24325097-0 2013 [Oxidative mechanism of uric acid induced CRP expression in human umbilical vein endothelial cells]. Uric Acid 24-33 C-reactive protein Homo sapiens 42-45
24325097-1 2013 OBJECTIVE: To explore the oxidative mechanism of uric acid (UA) induced CRP expression in human umbilical vein endothelial cells. Uric Acid 49-58 C-reactive protein Homo sapiens 72-75
24325097-1 2013 OBJECTIVE: To explore the oxidative mechanism of uric acid (UA) induced CRP expression in human umbilical vein endothelial cells. Uric Acid 60-62 C-reactive protein Homo sapiens 72-75
24325097-5 2013 The effects of N-acetyl cysteine (NAC) on UA-induced levels of ROS, mRNA and protein of CRP in HUVECs were also observed. Uric Acid 42-44 C-reactive protein Homo sapiens 88-91
24325097-6 2013 RESULTS: The results demonstrated that UA could significantly increase the mRNA and protein expression of CRP in HUVECs in time- and concentration-dependent manners. Uric Acid 39-41 C-reactive protein Homo sapiens 106-109
24325097-7 2013 HUVECs were stimulated with 12 mg/dL UA at 6 h, mRNA and protein levels of CRP significantly higher than that of control level (P<0.05), reached a peak at 12 h (P<0. Uric Acid 37-39 C-reactive protein Homo sapiens 75-78
24325097-9 2013 NAC reduced UA-induced levels of ROS, mRNA and protein of CRP in HUVECs compared with those of 12 mg/dL UA induced group(P<0. Uric Acid 12-14 C-reactive protein Homo sapiens 58-61
24325097-11 2013 CONCLUSION: Uric acid significantly increased mRNA and protein expression of CRP in HUVECs in time- and concentration-dependent manners. Uric Acid 12-21 C-reactive protein Homo sapiens 77-80
23707617-0 2013 Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic beta cells. Uric Acid 0-9 Eph receptor B1 Rattus norvegicus 124-161
23707617-5 2013 Further examination on signal transduction pathways revealed that uric acid-induced ROS is involved in the activation of adenosine monophosphate-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK). Uric Acid 66-75 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 121-169
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 47-56 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 88-92
23707617-5 2013 Further examination on signal transduction pathways revealed that uric acid-induced ROS is involved in the activation of adenosine monophosphate-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK). Uric Acid 66-75 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 171-175
23707617-5 2013 Further examination on signal transduction pathways revealed that uric acid-induced ROS is involved in the activation of adenosine monophosphate-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK). Uric Acid 66-75 Eph receptor B1 Rattus norvegicus 182-219
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 47-56 Eph receptor B1 Rattus norvegicus 115-118
23707617-5 2013 Further examination on signal transduction pathways revealed that uric acid-induced ROS is involved in the activation of adenosine monophosphate-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK). Uric Acid 66-75 Eph receptor B1 Rattus norvegicus 221-224
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 47-56 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 145-149
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 170-179 Eph receptor B1 Rattus norvegicus 32-35
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 170-179 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 88-92
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 170-179 Eph receptor B1 Rattus norvegicus 115-118
23707617-7 2013 More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. Uric Acid 170-179 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 145-149
23707617-9 2013 While major urate transporter URAT1 is not expressed in beta cells, organic anion transporter (OAT) inhibitor successfully blocked the activation of ERK by uric acid. Uric Acid 156-165 Eph receptor B1 Rattus norvegicus 149-152
23707617-10 2013 Our data indicate that high uric acid levels induce oxidative damage and inhibit growth of rat pancreatic beta cells by activating the AMPK and ERK signal pathways. Uric Acid 28-37 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 135-139
23707617-10 2013 Our data indicate that high uric acid levels induce oxidative damage and inhibit growth of rat pancreatic beta cells by activating the AMPK and ERK signal pathways. Uric Acid 28-37 Eph receptor B1 Rattus norvegicus 144-147
23216460-6 2013 Insulin, homeostasis model assessment-R (HOMA-R), and body mass index (BMI) levels had a tendency to be in proportion to those of UA. Uric Acid 130-132 insulin Homo sapiens 0-7
23798679-6 2013 In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1beta. Uric Acid 69-78 NLR family pyrin domain containing 3 Homo sapiens 131-136
23798679-6 2013 In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1beta. Uric Acid 69-78 interleukin 1 beta Homo sapiens 167-175
23981619-8 2013 The association between UA and baPWV was observed after adjustment for gender, age, blood pressure, BMI, serum creatinine and high density lipoprotein, and insulin resistance (r = 0.186, P < 0.0001). Uric Acid 24-26 insulin Homo sapiens 156-163
23981619-11 2013 CONCLUSIONS: The UA level is positively associated with baPWV and MS, but the association between UA and MS is dependent on insulin resistance. Uric Acid 98-100 insulin Homo sapiens 124-131
23619996-3 2013 Here, we tried to identify new pathways regulated by the NLRP3 inflammasome in murine dendritic cells (DCs) in response to monosodium urate (MSU) crystals. Uric Acid 123-139 NLR family, pyrin domain containing 3 Mus musculus 57-62
23864233-5 2013 A genetic risk score was calculated by adding the uric acid increasing alleles in two SNPs (rs11722228 in SLC2A9 and rs2231142 in ABCG2) which were identified from our genome-wide association study on uric acid levels. Uric Acid 50-59 solute carrier family 2 member 9 Homo sapiens 106-112
23619996-3 2013 Here, we tried to identify new pathways regulated by the NLRP3 inflammasome in murine dendritic cells (DCs) in response to monosodium urate (MSU) crystals. Uric Acid 141-144 NLR family, pyrin domain containing 3 Mus musculus 57-62
23864233-5 2013 A genetic risk score was calculated by adding the uric acid increasing alleles in two SNPs (rs11722228 in SLC2A9 and rs2231142 in ABCG2) which were identified from our genome-wide association study on uric acid levels. Uric Acid 50-59 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 130-135
23338958-3 2013 The purpose of the study was to investigate the relationship between coronary flow assessed with TIMI frame count (TFC) and serum uric acid (SUA) levels in patients with CSX. Uric Acid 130-139 NK2 homeobox 5 Homo sapiens 170-173
23624269-0 2013 Uric acid attenuates nitric oxide production by decreasing the interaction between endothelial nitric oxide synthase and calmodulin in human umbilical vein endothelial cells: a mechanism for uric acid-induced cardiovascular disease development. Uric Acid 0-9 nitric oxide synthase 3 Homo sapiens 83-116
23996753-0 2013 [High concentration uric acid regulates endothelial function via miR-155]. Uric Acid 20-29 microRNA 155 Homo sapiens 65-72
23996753-1 2013 OBJECTIVE: To investigate high-concentration uric acid-induced endothelial dysfunction mediated by miR-155. Uric Acid 45-54 microRNA 155 Homo sapiens 99-106
23996753-4 2013 Real-time PCR was used to detect the expression of miR-155 in endothelial cells incubated with high-concentration uric acid. Uric Acid 114-123 microRNA 155 Homo sapiens 51-58
23996753-6 2013 RESULTS: The expression of eNOS and NO secretion decreased obviously in HUVECs incubated with 600 micromol/L uric acid. Uric Acid 109-118 nitric oxide synthase 3 Homo sapiens 27-31
23996753-8 2013 The expression of miR-155 in endothelial cells was upregulated after stimulation with high-concentration uric acid, and was inhibited by transfection of miR-155 inhibitor. Uric Acid 105-114 microRNA 155 Homo sapiens 18-25
23996753-8 2013 The expression of miR-155 in endothelial cells was upregulated after stimulation with high-concentration uric acid, and was inhibited by transfection of miR-155 inhibitor. Uric Acid 105-114 microRNA 155 Homo sapiens 153-160
23996753-9 2013 Expression of eNOS and secretion of NO were elevated in endothelial cells transfected with miR-155 inhibitor after incubation with high-concentration uric acid. Uric Acid 150-159 nitric oxide synthase 3 Homo sapiens 14-18
23996753-9 2013 Expression of eNOS and secretion of NO were elevated in endothelial cells transfected with miR-155 inhibitor after incubation with high-concentration uric acid. Uric Acid 150-159 microRNA 155 Homo sapiens 91-98
23996753-10 2013 CONCLUSION: High-concentration uric acid can down-regulate eNOS expression via miR-155 to induce endothelial dysfunction. Uric Acid 31-40 nitric oxide synthase 3 Homo sapiens 59-63
23996753-10 2013 CONCLUSION: High-concentration uric acid can down-regulate eNOS expression via miR-155 to induce endothelial dysfunction. Uric Acid 31-40 microRNA 155 Homo sapiens 79-86
23624269-8 2013 In vitro and in cell coimmunoprecipitation studies, however, revealed that uric acid significantly decreased the interaction between eNOS and calmodulin (CaM), an eNOS activator, although it did not change the intracellular CaM level. Uric Acid 75-84 nitric oxide synthase 3 Homo sapiens 133-137
23624269-0 2013 Uric acid attenuates nitric oxide production by decreasing the interaction between endothelial nitric oxide synthase and calmodulin in human umbilical vein endothelial cells: a mechanism for uric acid-induced cardiovascular disease development. Uric Acid 0-9 calmodulin 1 Homo sapiens 121-131
23624269-8 2013 In vitro and in cell coimmunoprecipitation studies, however, revealed that uric acid significantly decreased the interaction between eNOS and calmodulin (CaM), an eNOS activator, although it did not change the intracellular CaM level. Uric Acid 75-84 calmodulin 1 Homo sapiens 142-152
23624269-8 2013 In vitro and in cell coimmunoprecipitation studies, however, revealed that uric acid significantly decreased the interaction between eNOS and calmodulin (CaM), an eNOS activator, although it did not change the intracellular CaM level. Uric Acid 75-84 calmodulin 1 Homo sapiens 154-157
23624269-0 2013 Uric acid attenuates nitric oxide production by decreasing the interaction between endothelial nitric oxide synthase and calmodulin in human umbilical vein endothelial cells: a mechanism for uric acid-induced cardiovascular disease development. Uric Acid 191-200 nitric oxide synthase 3 Homo sapiens 83-116
23624269-8 2013 In vitro and in cell coimmunoprecipitation studies, however, revealed that uric acid significantly decreased the interaction between eNOS and calmodulin (CaM), an eNOS activator, although it did not change the intracellular CaM level. Uric Acid 75-84 nitric oxide synthase 3 Homo sapiens 163-167
23624269-8 2013 In vitro and in cell coimmunoprecipitation studies, however, revealed that uric acid significantly decreased the interaction between eNOS and calmodulin (CaM), an eNOS activator, although it did not change the intracellular CaM level. Uric Acid 75-84 calmodulin 1 Homo sapiens 224-227
23624269-9 2013 Like in HUVEC, uric acid also decreased eNOS-CaM interaction in bovine aortic EC. Uric Acid 15-24 nitric oxide synthase 3 Bos taurus 40-44
23624269-0 2013 Uric acid attenuates nitric oxide production by decreasing the interaction between endothelial nitric oxide synthase and calmodulin in human umbilical vein endothelial cells: a mechanism for uric acid-induced cardiovascular disease development. Uric Acid 191-200 calmodulin 1 Homo sapiens 121-131
23624269-9 2013 Like in HUVEC, uric acid also decreased eNOS-CaM interaction in bovine aortic EC. Uric Acid 15-24 calmodulin Bos taurus 45-48
23624269-3 2013 Using human umbilical vascular endothelial cells (HUVEC), we explored the molecular mechanism of uric acid on endothelial NO synthase (eNOS) activity and NO production. Uric Acid 97-106 nitric oxide synthase 3 Homo sapiens 135-139
23624269-10 2013 Finally, uric acid attenuated ionomycin-induced increase in the interaction between eNOS and CaM. Uric Acid 9-18 nitric oxide synthase 3 Homo sapiens 84-88
23624269-4 2013 Although high dose of uric acid (12mg/dl for 24h treatment) significantly decreased eNOS activity and NO production, it did not alter eNOS expression and phosphorylations at eNOS-Ser(1177), eNOS-Thr(495) and eNOS-Ser(114). Uric Acid 22-31 nitric oxide synthase 3 Homo sapiens 84-88
23624269-10 2013 Finally, uric acid attenuated ionomycin-induced increase in the interaction between eNOS and CaM. Uric Acid 9-18 calmodulin 1 Homo sapiens 93-96
26237060-5 2013 Substantial correlations between CD45(-)CD34(+) and conventional cardiovascular risk factors (hs-CRP, T2DM, serum uric acid and hypertension) were found in the patient cohort. Uric Acid 114-123 protein tyrosine phosphatase receptor type C Homo sapiens 33-37
23624269-11 2013 This study suggests firstly that uric acid decreased eNOS activity and NO production through reducing the binding between eNOS and CaM in EC. Uric Acid 33-42 nitric oxide synthase 3 Homo sapiens 53-57
23624269-11 2013 This study suggests firstly that uric acid decreased eNOS activity and NO production through reducing the binding between eNOS and CaM in EC. Uric Acid 33-42 nitric oxide synthase 3 Homo sapiens 122-126
23624269-11 2013 This study suggests firstly that uric acid decreased eNOS activity and NO production through reducing the binding between eNOS and CaM in EC. Uric Acid 33-42 calmodulin 1 Homo sapiens 131-134
23895583-5 2013 RESULTS: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. Uric Acid 67-69 endothelin 1 Mus musculus 120-132
23895583-5 2013 RESULTS: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. Uric Acid 67-69 endothelin 1 Mus musculus 244-256
23895583-6 2013 In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase. Uric Acid 32-34 C-reactive protein, pentraxin-related Mus musculus 105-123
23865526-5 2013 An involvement of MLN could explain the diverse findings in the epidemiology, immunology and pathology of MS, requiring a consideration of a complex infectious background, the human leucocyte antigens, as well as cosmic radiation causing geomagnetic disturbances, vitamin D deficiency, smoking, and lower levels of uric acid. Uric Acid 315-324 motilin Homo sapiens 18-21
23898911-2 2013 Several studies indicated that SAA genetic polymorphism rs12218 was associated with carotid atherosclerosis, peripheral arterial disease, and serum uric acid levels. Uric Acid 148-157 serum amyloid A1 cluster Homo sapiens 31-34
23800412-1 2013 ABCG2 is an important multidrug transporter involved also in urate transport, thus its mutations can lead to the development of gout and may also alter general drug absorption, distribution and excretion. Uric Acid 61-66 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
23935829-1 2013 Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. Uric Acid 16-25 insulin Homo sapiens 175-182
23876149-3 2013 The clean biochemical approach revealed that proteoliposomes comprising purified NPT1 as the only protein source transport various organic anions such as urate, p-aminohippuric acid (PAH), and acetylsalicylic acid (aspirin) in a membrane potential (Deltapsi)-driven and Cl(-) -dependent manner. Uric Acid 154-159 solute carrier family 17 member 1 Homo sapiens 81-85
23837669-0 2013 Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications. Uric Acid 14-30 C-type lectin domain family 12 member A Homo sapiens 79-125
23876149-4 2013 Human NPT1 carrying an SNP mutation, Thr269Ile, known to increase the risk of gout, exhibited 32% lower urate transport activity compared to the wild type protein, leading to the conclusion that NPT1 is the long searched for transporter responsible for renal urate excretion. Uric Acid 104-109 solute carrier family 17 member 1 Homo sapiens 6-10
23876149-4 2013 Human NPT1 carrying an SNP mutation, Thr269Ile, known to increase the risk of gout, exhibited 32% lower urate transport activity compared to the wild type protein, leading to the conclusion that NPT1 is the long searched for transporter responsible for renal urate excretion. Uric Acid 104-109 solute carrier family 17 member 1 Homo sapiens 195-199
23344781-2 2013 The identification of the role of NLRP3 inflammasome in the recognition of monosodium urate crystals and the subsequent release of IL-1beta was a milestone in the elucidation of the pathogenesis of this disorder. Uric Acid 75-91 NLR family pyrin domain containing 3 Homo sapiens 34-39
23876149-4 2013 Human NPT1 carrying an SNP mutation, Thr269Ile, known to increase the risk of gout, exhibited 32% lower urate transport activity compared to the wild type protein, leading to the conclusion that NPT1 is the long searched for transporter responsible for renal urate excretion. Uric Acid 259-264 solute carrier family 17 member 1 Homo sapiens 6-10
23876149-4 2013 Human NPT1 carrying an SNP mutation, Thr269Ile, known to increase the risk of gout, exhibited 32% lower urate transport activity compared to the wild type protein, leading to the conclusion that NPT1 is the long searched for transporter responsible for renal urate excretion. Uric Acid 259-264 solute carrier family 17 member 1 Homo sapiens 195-199
23998049-11 2013 CONCLUSION: In the present study, it was concluded that the serum uric acid levels linearly increased with increasing serum insulin levels, in newly diagnosed diabetic patients. Uric Acid 66-75 insulin Homo sapiens 124-131
24257178-7 2013 Pre-diabetes uric acid levels were positively correlated with TG, TC, LDL-C while HOMA-IR(TG:r = 0.29, TC:r = 0.33,LDL-C:r = 0.49, HOMA-IR:r = 0.51, P < 0.05) was negatively correlated (r = -0.30, P < 0.05)with the HbA1c. Uric Acid 13-22 component of oligomeric golgi complex 2 Homo sapiens 70-75
24257178-7 2013 Pre-diabetes uric acid levels were positively correlated with TG, TC, LDL-C while HOMA-IR(TG:r = 0.29, TC:r = 0.33,LDL-C:r = 0.49, HOMA-IR:r = 0.51, P < 0.05) was negatively correlated (r = -0.30, P < 0.05)with the HbA1c. Uric Acid 13-22 component of oligomeric golgi complex 2 Homo sapiens 115-120
24257178-8 2013 CONCLUSION: The levels of PDM uric acid might both be related with TC, TG, LDL-C and HOMA-IR. Uric Acid 30-39 component of oligomeric golgi complex 2 Homo sapiens 75-80
23721306-8 2013 The detection limit (S/N = 3) of the biosensors for cholesterol and uric acid was 0.1 muM and for glucose it was 1 muM. Uric Acid 68-77 latexin Homo sapiens 86-89
23762324-0 2013 A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1beta production by human first trimester trophoblast. Uric Acid 11-20 interleukin 1 beta Homo sapiens 85-93
23762324-8 2013 Furthermore, aPL stimulated the production of uric acid in a TLR4-dependent manner; and inhibition of uric acid prevented aPL-induced IL-1beta production by the trophoblast. Uric Acid 46-55 toll like receptor 4 Homo sapiens 61-65
23762324-8 2013 Furthermore, aPL stimulated the production of uric acid in a TLR4-dependent manner; and inhibition of uric acid prevented aPL-induced IL-1beta production by the trophoblast. Uric Acid 102-111 interleukin 1 beta Homo sapiens 134-142
23762324-9 2013 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid 67-76 toll like receptor 4 Homo sapiens 41-45
23762324-9 2013 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid 67-76 NLR family pyrin domain containing 3 Homo sapiens 136-141
23762324-9 2013 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid 67-76 PYD and CARD domain containing Homo sapiens 142-145
23762324-9 2013 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid 67-76 interleukin 1 beta Homo sapiens 170-178
23609011-4 2013 We examined the potential co-localization of NLRP3 inflammasome with mitochondria and seven other organelles under adenosine triphosphate, nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal microscopy approach. Uric Acid 152-168 NLR family, pyrin domain containing 3 Mus musculus 45-50
23443724-10 2013 Parameters affecting SCUBE1 levels were systolic and diastolic BP, sCD40L, lipid parameters, and uric acid levels. Uric Acid 97-106 signal peptide, CUB domain and EGF like domain containing 1 Homo sapiens 21-27
23642898-7 2013 The same negative relationships were found between UA and PTH (r=-0.266, P=0.007), and between UA and the phosphate reabsorption rate (r=-0.415, P<0.001). Uric Acid 51-53 parathyroid hormone Homo sapiens 58-61
23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 interleukin 10 Homo sapiens 83-88
23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 ubiquitin associated and SH3 domain containing B Homo sapiens 96-99
23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 interferon gamma Homo sapiens 102-111
23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 116-120
23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 122-127
23600826-6 2013 In contrast, IL-18 was up-regulated upon co-stimulation with fatty acids and uric acid. Uric Acid 77-86 interleukin 18 Homo sapiens 13-18
23423253-8 2013 Lower eGFRCysC and eGFRCr-CysC also had these same associations but also associated with obesity, albuminuria, hypertension, diabetes, higher triglycerides, higher C-reactive protein, and higher uric acid along non-GFR pathways. Uric Acid 195-204 cystatin C Homo sapiens 10-14
23360433-1 2013 BACKGROUND: Uric acid (UA) is known to be associated with excess adiposity and insulin resistance. Uric Acid 12-21 insulin Homo sapiens 79-86
23360433-1 2013 BACKGROUND: Uric acid (UA) is known to be associated with excess adiposity and insulin resistance. Uric Acid 23-25 insulin Homo sapiens 79-86
23360433-11 2013 UA is a potential target for preventing decreases in insulin sensitivity and rises in blood pressure and cholesterol. Uric Acid 0-2 insulin Homo sapiens 53-60
23685841-4 2013 We found that type I IFN supports the upregulation of xanthine dehydrogenase, which metabolizes the xanthine accumulating in infected erythrocytes to uric acid. Uric Acid 150-159 xanthine dehydrogenase Homo sapiens 54-76
23685841-5 2013 Uric acid crystals trigger mast cells to release soluble Flt3l from a pre-synthesized membrane-associated precursor. Uric Acid 0-9 fms related receptor tyrosine kinase 3 ligand Homo sapiens 57-62
23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 49-53
24125604-5 2013 Data from the univariate logistic regression analysis showed that with the increase of uric acid, the prevalence rates of coronary artery calcium also increased(OR2-3Q = 1.41, 95% CI:1.02-1.95, P = 0.040; OR4Q = 2.60, 95% CI:1.78-3.80, P < 0.001). Uric Acid 87-96 olfactory receptor family 4 subfamily Q member 2 (gene/pseudogene) Homo sapiens 205-213
23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 144-148
23667704-8 2013 The candidate C. neoformans uric acid catabolic genes identified were named: URO1 (urate oxidase), URO2 (HIU hydrolase), URO3 (OHCU decarboxylase), DAL1 (allantoinase), DAL2,3,3 (allantoicase-ureidoglycolate hydrolase fusion protein), and URE1 (urease). Uric Acid 28-37 erythrocyte membrane protein band 4.1 like 3 Homo sapiens 148-152
23738004-1 2013 BACKGROUND: The toll-like receptor (TLR)4-interleukin1beta (IL1beta) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation. Uric Acid 106-122 interleukin 1 beta Homo sapiens 60-67
23738004-1 2013 BACKGROUND: The toll-like receptor (TLR)4-interleukin1beta (IL1beta) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation. Uric Acid 124-127 interleukin 1 beta Homo sapiens 60-67
23570342-7 2013 In this population, WC is directly and significantly associated with TNF-alpha, VEGF, hsCRP; TNF-alpha is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Uric Acid 141-150 adiponectin, C1Q and collagen domain containing Homo sapiens 207-218
23802423-2 2013 Dissolution of uric acid crystals into soluble allantoin by the enzyme uricase might provide a better alternative for the treatment of gout. Uric Acid 15-24 urate oxidase (pseudogene) Homo sapiens 71-78
23202347-7 2013 The sensitivity of AA, DA and UA at the sensor is 0.012, 4.031, 0.605 muA/muM respectively. Uric Acid 30-32 latexin Homo sapiens 74-77
23552988-0 2013 Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. Uric Acid 86-95 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 64-69
23552988-1 2013 A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations. Uric Acid 154-163 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 54-97
23552988-1 2013 A loss-of-function mutation (Q141K, rs2231142) in the ATP-binding cassette, subfamily G, member 2 gene (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, and European and African Americans; however, less is known about these associations in other populations. Uric Acid 154-163 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 104-109
23576175-1 2013 A series of studies have recently demonstrated that the release of interleukin 1beta induced by monosodium urate crystals is central to the experimental gouty arthritis. Uric Acid 96-112 interleukin 1 beta Mus musculus 67-84
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 66-82 PML nuclear body scaffold Homo sapiens 31-34
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 66-82 interleukin 1 beta Homo sapiens 97-105
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 66-82 PML nuclear body scaffold Homo sapiens 147-150
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 174-179
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 84-87 PML nuclear body scaffold Homo sapiens 31-34
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 84-87 interleukin 1 beta Homo sapiens 97-105
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 84-87 PML nuclear body scaffold Homo sapiens 147-150
23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 84-87 NLR family pyrin domain containing 3 Homo sapiens 174-179
23208085-6 2013 The example glucose biosensor has a linear response up to 30 mM, with a high sensitivity of 0.50 muA mM-1 mm-2, and excellent anti-interference ability against lactate, uric acid and ascorbic acid. Uric Acid 169-178 Mix1 homeobox-like 1 (Xenopus laevis) Mus musculus 101-110
23498698-1 2013 A new method for uric acid (UA) determination based on the quenching of the cathodic ECL of the tris(2,2-bipyridine)ruthenium(II)-uricase system is described. Uric Acid 28-30 urate oxidase (pseudogene) Homo sapiens 130-137
23429061-0 2013 Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-D-glucosaminidase (NAG) excretion in chronic lead-exposed workers. Uric Acid 53-62 metallothionein 1A Homo sapiens 0-18
23498698-3 2013 The uric acid biosensing is based on the ECL quenching produced by uric acid over the cathodic ECL caused by immobilized Ru(bpy)3(2+) in the presence of uricase. Uric Acid 4-13 urate oxidase (pseudogene) Homo sapiens 153-160
23498698-1 2013 A new method for uric acid (UA) determination based on the quenching of the cathodic ECL of the tris(2,2-bipyridine)ruthenium(II)-uricase system is described. Uric Acid 17-26 urate oxidase (pseudogene) Homo sapiens 130-137
23498698-3 2013 The uric acid biosensing is based on the ECL quenching produced by uric acid over the cathodic ECL caused by immobilized Ru(bpy)3(2+) in the presence of uricase. Uric Acid 67-76 urate oxidase (pseudogene) Homo sapiens 153-160
22752451-0 2013 The effects of mammalian target of rapamycin inhibitors on serum uric acid levels in renal transplant patients. Uric Acid 65-74 mechanistic target of rapamycin kinase Homo sapiens 15-44
23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Uric Acid 44-53 NLR family pyrin domain containing 3 Homo sapiens 8-13
23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Uric Acid 44-53 interleukin 1 alpha Homo sapiens 82-91
23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Uric Acid 44-53 interleukin 1 beta Homo sapiens 151-159
23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Uric Acid 44-53 interleukin 1 alpha Homo sapiens 164-173
23741759-14 2013 BNP level (summary hazard ratio [HR] 2.42; 95% confidence interval [CI], 1.72 to 3.41) and presence of pericardial effusion were strong predictors of mortality (summary HR 2.43; 95% CI, 1.57 to 3.77) RA size and uric acid were also predictive of mortality, but fractional area change (FAC) showed no significant ability to predict mortality, and data on TAPSE were insufficient. Uric Acid 212-221 natriuretic peptide B Homo sapiens 0-3
24376319-0 2013 Uric acid induces caspase-1 activation, IL-1beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes. Uric Acid 0-9 caspase 1 Homo sapiens 18-27
24376319-0 2013 Uric acid induces caspase-1 activation, IL-1beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes. Uric Acid 0-9 interleukin 1 beta Homo sapiens 40-48
24376319-0 2013 Uric acid induces caspase-1 activation, IL-1beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes. Uric Acid 0-9 purinergic receptor P2X 7 Homo sapiens 63-76
24376319-1 2013 BACKGROUND: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1beta (IL-1beta). Uric Acid 12-17 NLR family pyrin domain containing 3 Homo sapiens 100-105
24376319-1 2013 BACKGROUND: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1beta (IL-1beta). Uric Acid 12-17 caspase 1 Homo sapiens 117-126
24376319-1 2013 BACKGROUND: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1beta (IL-1beta). Uric Acid 12-17 interleukin 1 beta Homo sapiens 190-198
24376319-2 2013 Purinergic receptor P2X7 plays a role in the urate induced NALP3 activation. Uric Acid 45-50 purinergic receptor P2X 7 Homo sapiens 20-24
24376319-2 2013 Purinergic receptor P2X7 plays a role in the urate induced NALP3 activation. Uric Acid 45-50 NLR family pyrin domain containing 3 Homo sapiens 59-64
24376319-8 2013 RESULTS: Urate induced caspase-1 activation and IL-1beta release by lymphocytes. Uric Acid 9-14 caspase 1 Homo sapiens 23-32
24376319-8 2013 RESULTS: Urate induced caspase-1 activation and IL-1beta release by lymphocytes. Uric Acid 9-14 interleukin 1 beta Homo sapiens 48-56
24376319-11 2013 CONCLUSIONS: Urate, a well defined danger signal, stimulates directly human lymphocytes in a P2X7 dependent way. Uric Acid 13-18 purinergic receptor P2X 7 Homo sapiens 93-97
23507749-5 2013 The anti-oxidant assays have a high correlation with uric acid, especially the TAS (0.922) and FRAP assay (0.869). Uric Acid 53-62 mechanistic target of rapamycin kinase Homo sapiens 95-99
23344472-0 2013 Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Uric Acid 95-104 uromodulin Homo sapiens 37-47
23344472-1 2013 Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. Uric Acid 160-169 uromodulin Homo sapiens 0-10
23344472-1 2013 Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. Uric Acid 160-169 uromodulin Homo sapiens 12-16
23344472-1 2013 Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. Uric Acid 226-235 uromodulin Homo sapiens 0-10
23344472-1 2013 Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. Uric Acid 226-235 uromodulin Homo sapiens 12-16
23344472-5 2013 UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. Uric Acid 61-70 uromodulin Homo sapiens 0-4
23344472-5 2013 UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. Uric Acid 92-101 uromodulin Homo sapiens 0-4
23344472-5 2013 UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid concentration, suggesting a primary effect on renal tubular handling of urate. Uric Acid 174-179 uromodulin Homo sapiens 0-4
23344472-6 2013 These UMOD genetic marker-on-trait associations for uric acid were replicated in the independent American cohort. Uric Acid 52-61 uromodulin Homo sapiens 6-10
23344472-8 2013 Thus, UMOD promoter variants seem to initiate a cascade of transcriptional and biochemical changes influencing UMOD secretion, leading to altered plasma uric acid levels. Uric Acid 153-162 uromodulin Homo sapiens 6-10
23344472-8 2013 Thus, UMOD promoter variants seem to initiate a cascade of transcriptional and biochemical changes influencing UMOD secretion, leading to altered plasma uric acid levels. Uric Acid 153-162 uromodulin Homo sapiens 111-115
23534916-7 2013 All three loci belong to SLC2A9 gene, considered to have a major role in the regulation of serum uric acid concentration (rs6449213, rs1014290 and rs737267). Uric Acid 97-106 solute carrier family 2 member 9 Homo sapiens 25-31
23291366-0 2013 Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Uric Acid 88-93 solute carrier family 22 member 12 Homo sapiens 26-31
23439376-7 2013 Conversely, the most important urine variable in the causation of uric acid stones is low urine pH, linked to insulin resistance as a component of obesity and the metabolic syndrome. Uric Acid 66-75 insulin Homo sapiens 110-117
23266153-9 2013 A positive relation was also found between uric acid and insulin levels in the metabolic syndrome patients with morbid obesity. Uric Acid 43-52 insulin Homo sapiens 57-64
23387472-6 2013 Up-regulation of NLRP3 mRNA by UV was also found to be dependent on UV-induced uric acid. Uric Acid 79-88 NLR family, pyrin domain containing 3 Mus musculus 17-22
23387472-7 2013 This suggested that the target of UV-induced uric acid included proteins involved in the formation and activation of the NLRP3-inflammasome. Uric Acid 45-54 NLR family, pyrin domain containing 3 Mus musculus 121-126
23292187-0 2013 Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages. Uric Acid 0-16 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 27-30
23292187-0 2013 Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages. Uric Acid 0-16 protein tyrosine kinase 2 beta Homo sapiens 31-35
23292187-0 2013 Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages. Uric Acid 0-16 peptidase inhibitor 3 Homo sapiens 36-39
23303409-2 2013 Rodents have an active uricase, thus requiring large doses of fructose to increase plasma UA and to induce metabolic syndrome and renal hemodynamic changes. Uric Acid 90-92 urate oxidase Rattus norvegicus 23-30
22564045-2 2013 In addition, a member of the OAT family, urate transporter 1 (URAT1), is involved in the reabsorption of uric acid from the renal tubule. Uric Acid 105-114 solute carrier family 22 member 12 Homo sapiens 41-60
22564045-2 2013 In addition, a member of the OAT family, urate transporter 1 (URAT1), is involved in the reabsorption of uric acid from the renal tubule. Uric Acid 105-114 solute carrier family 22 member 12 Homo sapiens 62-67
22564045-3 2013 Benzbromarone inhibits URAT1 to block uric acid reabsorption. Uric Acid 38-47 solute carrier family 22 member 12 Homo sapiens 23-28
22564045-4 2013 METHODS: Our group previously observed higher salivary uric acid levels than serum levels in patients taking benzbromarone, and reported the possible existence of URAT1-like uric acid excretion mechanism in the salivary gland. Uric Acid 174-183 solute carrier family 22 member 12 Homo sapiens 163-168
22564045-5 2013 The purpose of this study was to elucidate the uric acid excretion mechanism in salivary gland tissues using rabbit anti-human OAT1-4 and URAT1 polyclonal antibodies with EnVision( ) system. Uric Acid 47-56 solute carrier family 22 member 6 Homo sapiens 127-133
22564045-5 2013 The purpose of this study was to elucidate the uric acid excretion mechanism in salivary gland tissues using rabbit anti-human OAT1-4 and URAT1 polyclonal antibodies with EnVision( ) system. Uric Acid 47-56 solute carrier family 22 member 12 Homo sapiens 138-143
22564045-13 2013 These results may support the previous speculation that benzbromarone inhibits URAT1 to block uric acid reabsorption in the salivary gland, resulting in higher salivary uric acid levels than serum levels. Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 79-84
22564045-13 2013 These results may support the previous speculation that benzbromarone inhibits URAT1 to block uric acid reabsorption in the salivary gland, resulting in higher salivary uric acid levels than serum levels. Uric Acid 169-178 solute carrier family 22 member 12 Homo sapiens 79-84
23283992-4 2013 We therefore investigated whether uric acid could alter E-cadherin expression and EMT in the kidney of hyperuricemic rats and in cultured renal tubular cells (NRK cells). Uric Acid 34-43 cadherin 1 Rattus norvegicus 56-66
23283992-6 2013 Allopurinol significantly inhibited uric acid-induced changes in E-cadherin and alpha-SMA with an amelioration of renal fibrosis at 6 wk. Uric Acid 36-45 cadherin 1 Rattus norvegicus 65-75
23283992-6 2013 Allopurinol significantly inhibited uric acid-induced changes in E-cadherin and alpha-SMA with an amelioration of renal fibrosis at 6 wk. Uric Acid 36-45 actin gamma 2, smooth muscle Rattus norvegicus 80-89
23283992-8 2013 Uric acid increased expression of transcriptional factors associated with decreased synthesis of E-cadherin (Snail and Slug). Uric Acid 0-9 cadherin 1 Rattus norvegicus 97-107
23283992-8 2013 Uric acid increased expression of transcriptional factors associated with decreased synthesis of E-cadherin (Snail and Slug). Uric Acid 0-9 snail family transcriptional repressor 2 Rattus norvegicus 119-123
23283992-9 2013 Uric acid also increased the degradation of E-cadherin via ubiquitination, which is of importance since downregulation of E-cadherin is considered to be a triggering mechanism for EMT. Uric Acid 0-9 cadherin 1 Rattus norvegicus 44-54
23283992-9 2013 Uric acid also increased the degradation of E-cadherin via ubiquitination, which is of importance since downregulation of E-cadherin is considered to be a triggering mechanism for EMT. Uric Acid 0-9 cadherin 1 Rattus norvegicus 122-132
23283992-10 2013 In conclusion, uric acid induces EMT of renal tubular cells decreasing E-cadherin synthesis via an activation of Snail and Slug as well as increasing the degradation of E-cadherin. Uric Acid 15-24 cadherin 1 Rattus norvegicus 71-81
23283992-10 2013 In conclusion, uric acid induces EMT of renal tubular cells decreasing E-cadherin synthesis via an activation of Snail and Slug as well as increasing the degradation of E-cadherin. Uric Acid 15-24 snail family transcriptional repressor 2 Rattus norvegicus 123-127
23283992-10 2013 In conclusion, uric acid induces EMT of renal tubular cells decreasing E-cadherin synthesis via an activation of Snail and Slug as well as increasing the degradation of E-cadherin. Uric Acid 15-24 cadherin 1 Rattus norvegicus 169-179
23245858-8 2013 CONCLUSIONS: Lower concentration of UA and in the third trimester the activity of ALDH3A1 in saliva of pregnant women could be a risk factor of, e.g. oral pathologies. Uric Acid 36-38 aldehyde dehydrogenase 3 family member A1 Homo sapiens 82-89
23280587-1 2013 OBJECTIVE: To identify macrophage-independent sources of transforming growth factor beta1 (TGFbeta1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and to determine how TGFbeta1 alters MSU crystal-recruited neutrophil functions. Uric Acid 119-147 transforming growth factor, beta 1 Mus musculus 57-89
23280587-1 2013 OBJECTIVE: To identify macrophage-independent sources of transforming growth factor beta1 (TGFbeta1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and to determine how TGFbeta1 alters MSU crystal-recruited neutrophil functions. Uric Acid 119-147 transforming growth factor, beta 1 Mus musculus 91-99
23280587-1 2013 OBJECTIVE: To identify macrophage-independent sources of transforming growth factor beta1 (TGFbeta1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and to determine how TGFbeta1 alters MSU crystal-recruited neutrophil functions. Uric Acid 149-152 transforming growth factor, beta 1 Mus musculus 57-89
23280587-1 2013 OBJECTIVE: To identify macrophage-independent sources of transforming growth factor beta1 (TGFbeta1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and to determine how TGFbeta1 alters MSU crystal-recruited neutrophil functions. Uric Acid 149-152 transforming growth factor, beta 1 Mus musculus 91-99
23291366-0 2013 Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Uric Acid 88-93 solute carrier family 22 member 12 Homo sapiens 33-41
23291366-0 2013 Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Uric Acid 88-93 solute carrier family 2 member 9 Homo sapiens 47-53
23291366-0 2013 Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Uric Acid 88-93 solute carrier family 2 member 9 Homo sapiens 55-61
23291366-8 2013 CONCLUSIONS: It is demonstrated that functional cooperation of URAT1 and URATv1 is essential for renal reabsorption of urate, and in the established system influence of drugs on SUA is reflected in the alteration of urate permeability across the renal tubular epithelial cells. Uric Acid 119-124 solute carrier family 22 member 12 Homo sapiens 63-68
23291366-8 2013 CONCLUSIONS: It is demonstrated that functional cooperation of URAT1 and URATv1 is essential for renal reabsorption of urate, and in the established system influence of drugs on SUA is reflected in the alteration of urate permeability across the renal tubular epithelial cells. Uric Acid 119-124 solute carrier family 2 member 9 Homo sapiens 73-79
22307865-6 2013 The activity of leptin on XO was determined by monitoring the conversion of XAN to uric acid at 293 nm using a Beckman DU 800 UV-visible spectrophotometer. Uric Acid 83-92 leptin Homo sapiens 16-22
23348497-2 2013 A recent study in Icelanders identified a rare missense single nucleotide polymorphism (SNP) in the ALDH16A1 gene, ALDH16A1*2, to be associated with gout and serum uric acid levels. Uric Acid 164-173 aldehyde dehydrogenase 16 family member A1 Homo sapiens 100-108
23442371-10 2013 Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Uric Acid 40-49 complement C1q A chain Homo sapiens 151-154
23442371-10 2013 Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Uric Acid 40-49 alanyl aminopeptidase, membrane Homo sapiens 155-158
23442371-10 2013 Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Uric Acid 40-49 alanyl aminopeptidase, membrane Homo sapiens 165-168
23442371-10 2013 Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Uric Acid 40-49 alanyl aminopeptidase, membrane Homo sapiens 165-168
23442371-10 2013 Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Uric Acid 40-49 alanyl aminopeptidase, membrane Homo sapiens 165-168
23348497-2 2013 A recent study in Icelanders identified a rare missense single nucleotide polymorphism (SNP) in the ALDH16A1 gene, ALDH16A1*2, to be associated with gout and serum uric acid levels. Uric Acid 164-173 aldehyde dehydrogenase 16 family member A1 Homo sapiens 115-123
23348497-8 2013 Molecular modeling predicts that both the short and long forms of human ALDH16A1 protein would lack catalytic activity but may interact with the hypoxanthine-guanine phosphoribosyltransferase (HPRT1) protein, a key enzyme involved in uric acid metabolism and gout. Uric Acid 234-243 aldehyde dehydrogenase 16 family member A1 Homo sapiens 72-80
23348497-8 2013 Molecular modeling predicts that both the short and long forms of human ALDH16A1 protein would lack catalytic activity but may interact with the hypoxanthine-guanine phosphoribosyltransferase (HPRT1) protein, a key enzyme involved in uric acid metabolism and gout. Uric Acid 234-243 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 145-191
23348497-8 2013 Molecular modeling predicts that both the short and long forms of human ALDH16A1 protein would lack catalytic activity but may interact with the hypoxanthine-guanine phosphoribosyltransferase (HPRT1) protein, a key enzyme involved in uric acid metabolism and gout. Uric Acid 234-243 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 193-198
23307580-6 2013 Thus far, SCL22A12, SCL2A9, and GLUT9 have been found to have the greatest variation and most influence on serum urate levels. Uric Acid 113-118 solute carrier family 2 member 9 Homo sapiens 32-37
23324449-5 2013 In addition, the detection sensitivities for DA and UA by DPV were 1.03 muA muM(-1) and 2.09 muA muM(-1), respectively, which were much higher than those from a cyclic voltammogram. Uric Acid 52-54 PWWP domain containing 3A, DNA repair factor Homo sapiens 76-82
23324449-5 2013 In addition, the detection sensitivities for DA and UA by DPV were 1.03 muA muM(-1) and 2.09 muA muM(-1), respectively, which were much higher than those from a cyclic voltammogram. Uric Acid 52-54 PWWP domain containing 3A, DNA repair factor Homo sapiens 97-103
23422251-2 2013 Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout. Uric Acid 201-206 solute carrier family 2 member 9 Homo sapiens 125-157
23422251-2 2013 Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout. Uric Acid 201-206 solute carrier family 2 member 9 Homo sapiens 164-170
23187309-0 2013 Electrochemical-surface enhanced Raman spectroscopy (E-SERS) of uric acid: a potential rapid diagnostic method for early preeclampsia detection. Uric Acid 64-73 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 55-59
23187309-2 2013 The preliminary steps towards developing a rapid tool for early diagnosis of preeclampsia using electrochemical SERS (E-SERS) for the detection of uric acid in urine are presented herein. Uric Acid 147-156 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 112-116
23187309-2 2013 The preliminary steps towards developing a rapid tool for early diagnosis of preeclampsia using electrochemical SERS (E-SERS) for the detection of uric acid in urine are presented herein. Uric Acid 147-156 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 120-124
23187309-3 2013 Characterization of the uric acid species was completed using cyclic voltammetry, UV spectroscopy, Raman spectroscopy and electrochemical surface-enhanced Raman spectroscopy (E-SERS). Uric Acid 24-33 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 177-181
23187309-4 2013 E-SERS was capable of easily detecting uric acid directly at concentrations <1 mM in urine simulant, without the need for costly enzymes and bulky equipment, and thus demonstrates promise as a rapid point-of-care diagnostic tool for detection of early onset preeclampsia in developing nation settings. Uric Acid 39-48 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 2-6
23164828-7 2013 Patients with NMO with lower serum UA concentrations tended to be positive for OB, to have higher CSF protein and MBP concentrations, and to have higher WBC counts and 24 hour IgG index, but no correlation was statistically significant. Uric Acid 35-37 myelin basic protein Homo sapiens 114-117
23278361-9 2013 When added to cardiac troponin T (cTnT), uric acid significantly increased the AUC of cTnT from 0 89 (95%Cl 0 85-0 93) to 0 92 (95%Cl 0 89-0 95, P = 0 020 for comparison). Uric Acid 41-50 troponin T2, cardiac type Homo sapiens 14-32
23278361-9 2013 When added to cardiac troponin T (cTnT), uric acid significantly increased the AUC of cTnT from 0 89 (95%Cl 0 85-0 93) to 0 92 (95%Cl 0 89-0 95, P = 0 020 for comparison). Uric Acid 41-50 troponin T2, cardiac type Homo sapiens 34-38
23278361-9 2013 When added to cardiac troponin T (cTnT), uric acid significantly increased the AUC of cTnT from 0 89 (95%Cl 0 85-0 93) to 0 92 (95%Cl 0 89-0 95, P = 0 020 for comparison). Uric Acid 41-50 troponin T2, cardiac type Homo sapiens 86-90
23137955-5 2013 In this study, polydatin showed inhibitory activities on xanthine oxidase to repress the level of serum uric acid in vivo and in vitro. Uric Acid 104-113 xanthine dehydrogenase Mus musculus 57-73
22865000-8 2013 The higher CRP group was discriminated by the above variables in addition to lower VO(2max), serum metabolic syndrome components (triglycerides, glucose, and HDL cholesterol), higher insulin, homeostasis assessment of insulin resistance, uric acid, gamma-GT, and homocysteine. Uric Acid 238-247 C-reactive protein Homo sapiens 11-14
23517319-7 2013 Our results suggest that the translucent skin may be due to repression of Bmdysb in the ov mutants and that Bmdysb plays an important role in the formation and accumulation of urate granules in the silkworm epidermis. Uric Acid 176-181 dysbindin protein homolog Bombyx mori 108-114
23222419-9 2013 The multivariate-adjusted Cox regression demonstrated a greater hazard ratio for ESRD for subjects in the 4th and 3rd quartiles of uric acid compared with the 1st [4.8 (2.6-8.9; P < 0.001) and 2.9 (1.6-5.3; P < 0.001)]. Uric Acid 131-140 cytochrome c oxidase subunit 8A Homo sapiens 26-29
23312318-7 2013 Using UOx as a model system, we have developed a simple and effective sensing platform for assay of uric acid at physiological levels. Uric Acid 100-109 urate oxidase (pseudogene) Homo sapiens 6-9
23544272-1 2013 Several genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) of ABCG2 and SLC22A12 were strongly associated with serum uric acid (SUA), but those of methylene tetrahydrofolate reductase (MTHFR) were not. Uric Acid 163-172 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-113
23544272-1 2013 Several genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) of ABCG2 and SLC22A12 were strongly associated with serum uric acid (SUA), but those of methylene tetrahydrofolate reductase (MTHFR) were not. Uric Acid 163-172 solute carrier family 22 member 12 Homo sapiens 118-126
23129794-6 2013 GLUT5- and GLUT2-mediated fructose effects on intestinal electrolyte transporters, hepatic uric acid metabolism, as well as renal and cardiomyocyte function, may play a role in fructose-induced hypertension. Uric Acid 91-100 solute carrier family 2 member 5 Homo sapiens 0-5
23148994-1 2013 BACKGROUND: Hypouricemia is a disorder that serum urate level is less than 2.0 mg/dl, and relatively common in the Japanese population, where the main genetic cause of hypouricemia is W258X and R90H mutations in human urate trasnsporter 1(SLC22A12). Uric Acid 50-55 solute carrier family 22 member 12 Homo sapiens 239-247
22794932-4 2013 The sensitivity at 0.700V was (1.94+-0.03) mAM(-1) (r=0.9991), with a linear range between 0.25 and 5.00mM, a detection limit of 2.2muM and a quantification limit of 6.7muM with minimum interference from lactose (1.5%), maltose (5.7%), galactose (1.2%), ascorbic acid (1.0%), and uric acid (3.3%). Uric Acid 280-289 mastermind like transcriptional coactivator 1 Mus musculus 43-49
23129794-6 2013 GLUT5- and GLUT2-mediated fructose effects on intestinal electrolyte transporters, hepatic uric acid metabolism, as well as renal and cardiomyocyte function, may play a role in fructose-induced hypertension. Uric Acid 91-100 solute carrier family 2 member 2 Homo sapiens 11-16
23311699-17 2013 CONCLUSIONS: The main factors associated with UA increase were altered BMI (overweight and obesity), muscle hypotrophy (MMI), higher levels of urea, triglycerides, and CRP. Uric Acid 46-48 C-reactive protein Homo sapiens 168-171
23248282-1 2013 Urate is the end product of purine metabolism in humans, owing to the evolutionary disruption of the gene encoding urate oxidase (UOx). Uric Acid 0-5 urate oxidase (pseudogene) Homo sapiens 115-128
23248282-1 2013 Urate is the end product of purine metabolism in humans, owing to the evolutionary disruption of the gene encoding urate oxidase (UOx). Uric Acid 0-5 urate oxidase (pseudogene) Homo sapiens 130-133
23248282-5 2013 In rodents, functional UOx catalyzes urate oxidation to allantoin. Uric Acid 37-42 urate oxidase Mus musculus 23-26
23248282-6 2013 We found that UOx KO mice with a constitutive mutation of the gene have increased concentrations of brain urate. Uric Acid 106-111 urate oxidase Mus musculus 14-17
23248282-7 2013 By contrast, UOx transgenic (Tg) mice overexpressing the enzyme have reduced brain urate concentrations. Uric Acid 83-88 urate oxidase Mus musculus 13-16
23286293-1 2013 Xanthine oxidoreductase (XOR) catalyzes the final two reactions that lead to uric acid formation. Uric Acid 77-86 xanthine dehydrogenase Homo sapiens 0-23
23327525-5 2013 Novel approaches to urate lowering have led to mechanism-based therapies such as urate synthesis inhibitors (febuxostat is already FDA approved and BCX4208 is in development), URAT-1 inhibitors promoting renal uric acid excretion (lesinurad), and recombinant uricase to directly catabolize urate (pegloticase). Uric Acid 20-25 solute carrier family 22 member 12 Homo sapiens 176-182
23327525-5 2013 Novel approaches to urate lowering have led to mechanism-based therapies such as urate synthesis inhibitors (febuxostat is already FDA approved and BCX4208 is in development), URAT-1 inhibitors promoting renal uric acid excretion (lesinurad), and recombinant uricase to directly catabolize urate (pegloticase). Uric Acid 20-25 urate oxidase (pseudogene) Homo sapiens 259-266
23327525-5 2013 Novel approaches to urate lowering have led to mechanism-based therapies such as urate synthesis inhibitors (febuxostat is already FDA approved and BCX4208 is in development), URAT-1 inhibitors promoting renal uric acid excretion (lesinurad), and recombinant uricase to directly catabolize urate (pegloticase). Uric Acid 210-219 solute carrier family 22 member 12 Homo sapiens 176-182
23286293-1 2013 Xanthine oxidoreductase (XOR) catalyzes the final two reactions that lead to uric acid formation. Uric Acid 77-86 xanthine dehydrogenase Homo sapiens 25-28
23944620-12 2013 There was a significant association between the functional capacity as assessed by NYHA class and the mean of adiponectin and uric acid, these means that higher levels of adiponectin and uric acid were associated with a higher functional class in patients with CHF (p=0.03 and p=0.04 respectively). Uric Acid 126-135 adiponectin, C1Q and collagen domain containing Homo sapiens 171-182
24397505-15 2013 Yolk CORT concentration was correlated with plasma uric acid concentration during CORT supplementation. Uric Acid 51-60 CORT Gallus gallus 5-9
23944620-12 2013 There was a significant association between the functional capacity as assessed by NYHA class and the mean of adiponectin and uric acid, these means that higher levels of adiponectin and uric acid were associated with a higher functional class in patients with CHF (p=0.03 and p=0.04 respectively). Uric Acid 187-196 adiponectin, C1Q and collagen domain containing Homo sapiens 110-121
24397505-15 2013 Yolk CORT concentration was correlated with plasma uric acid concentration during CORT supplementation. Uric Acid 51-60 CORT Gallus gallus 82-86
24397505-11 2013 From 3 to 7 d of dietary CORT supplementation, yolk CORT and plasma uric acid concentrations and H:L ratio increased whereas plasma glucose concentration decreased. Uric Acid 68-77 CORT Gallus gallus 25-29
23116398-1 2013 Xanthine oxidoreductase (XOR), a complex flavoprotein, catalyzes the metabolic reactions leading from hypoxanthine to xanthine and from xanthine to urate, and both reactions take place at the molybdenum cofactor. Uric Acid 148-153 xanthine dehydrogenase Homo sapiens 25-28
23607043-8 2013 The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. Uric Acid 53-62 cytochrome c oxidase subunit 8A Homo sapiens 4-7
23992315-8 2013 These results suggest that cN-II participates, through IMP dephosphorylation, in production of uric acid as the main end product of aminonitrogen in these animals. Uric Acid 95-104 5'-nucleotidase, cytosolic II Homo sapiens 27-32
23116398-6 2013 Although formation of NO from nitrite or formation of xanthine from urate by XOR ischemically feasible, it is not yet clear whether these reactions have any physiological significance since the reactions are catalyzed at a slow rate even under anaerobic conditions. Uric Acid 68-73 xanthine dehydrogenase Homo sapiens 77-80
23116398-1 2013 Xanthine oxidoreductase (XOR), a complex flavoprotein, catalyzes the metabolic reactions leading from hypoxanthine to xanthine and from xanthine to urate, and both reactions take place at the molybdenum cofactor. Uric Acid 148-153 xanthine dehydrogenase Homo sapiens 0-23
23348634-9 2013 CD14(dim)CD16(+) cells were associated to uric acid, surface CD143, and reduced count of total leukocytes and neutrophils. Uric Acid 42-51 CD14 molecule Homo sapiens 0-4
22971602-7 2013 By preloading nicotinate in SMCT1/URAT1-coexpressing Xenopus oocytes, URAT1-mediated urate transport was stimulated. Uric Acid 85-90 solute carrier family 5 member 8, gene 1 L homeolog Xenopus laevis 28-33
22971602-11 2013 The results from this study indicate the cooperative relationship of URAT1 and SMCT1, and that SMCT1 is a potential target for the alteration of renal handling of urate indirectly. Uric Acid 163-168 solute carrier family 5 member 8, gene 1 L homeolog Xenopus laevis 95-100
23348634-9 2013 CD14(dim)CD16(+) cells were associated to uric acid, surface CD143, and reduced count of total leukocytes and neutrophils. Uric Acid 42-51 Fc gamma receptor IIIa Homo sapiens 9-13
22893261-0 2013 A vasodilating beta1 blocker celiprolol inhibits muscular release of uric acid precursor in patients with essential hypertension. Uric Acid 69-78 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 15-20
23161873-9 2013 Interestingly, fructose-fed rats treated with ChREBP ASO had increased plasma uric acid, alanine transaminase, and aspartate aminotransferase concentrations. Uric Acid 78-87 MLX interacting protein-like Rattus norvegicus 46-52
22893261-1 2013 Although nonvasodilating beta1 blockers increase the levels of uric acid in serum, it is not known whether vasodilating beta1 blockers have a similar effect. Uric Acid 63-72 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 25-30
23291671-7 2013 When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT. Uric Acid 180-189 CIMT Homo sapiens 108-112
24872960-6 2013 In PIH cystatin C was significantly higher, 1.25 +- 0.9 unlike creatinine, 0.67 +- 0.14 and uric acid, 4.30 +- 1.0. Uric Acid 92-101 cystatin C Homo sapiens 7-17
23291671-7 2013 When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT. Uric Acid 180-189 CIMT Homo sapiens 108-112
23762544-9 2013 Uric acid, a byproduct of this reaction, has been linked to endothelial dysfunction, insulin resistance, and hypertension. Uric Acid 0-9 insulin Homo sapiens 85-92
23238572-7 2013 The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4x10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6x10(-10)). Uric Acid 64-73 solute carrier family 22 member 12 Homo sapiens 42-50
23282120-7 2013 Serum high-sensitivity C-reactive protein levels were also significantly higher in the nondipper group than the other groups (P<.001) and significantly correlated with serum UA (r=0.358, P<.001). Uric Acid 177-179 C-reactive protein Homo sapiens 23-41
23319019-1 2013 It has been recently demonstrated that interleukin 1beta (IL-1beta) plays a central role in monosodium urate crystal-induced inflammation and that the NALP3 inflammasome plays a major role in IL-1beta production. Uric Acid 92-108 interleukin 1 beta Homo sapiens 39-56
23319019-1 2013 It has been recently demonstrated that interleukin 1beta (IL-1beta) plays a central role in monosodium urate crystal-induced inflammation and that the NALP3 inflammasome plays a major role in IL-1beta production. Uric Acid 92-108 interleukin 1 beta Homo sapiens 58-66
22986926-10 2013 Elevation of the urate level and apoptotic cell ratio was attenuated by allopurinol and catalase, respectively. Uric Acid 17-22 catalase Homo sapiens 88-96
22933241-2 2013 Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals. Uric Acid 278-283 NLR family, pyrin domain containing 3 Mus musculus 36-84
22933241-2 2013 Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals. Uric Acid 278-283 NLR family, pyrin domain containing 3 Mus musculus 86-91
22933241-2 2013 Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals. Uric Acid 278-283 interleukin 1 beta Mus musculus 129-147
22933241-2 2013 Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals. Uric Acid 278-283 interleukin 1 beta Mus musculus 149-157
23405174-4 2013 We determined that P. falciparum-derived uric acid precipitates induce maturation of human dendritic cells, increasing the expression of cell surface co-stimulatory molecules such as CD80 and CD86, while decreasing human leukocyte antigen-DR expression. Uric Acid 41-50 CD80 molecule Homo sapiens 183-187
23943454-2 2013 We have shown that the Th2-inducing adjuvant aluminum hydroxide or exposure of the airways to house dust mite leads to the release of DAMPs: uric acid, ATP, and IL-1. Uric Acid 141-150 heart and neural crest derivatives expressed 2 Mus musculus 23-26
23437258-10 2013 Dose-response analysis showed the risk of type 2 diabetes was increased by 6% per 1 mg/dl increment in serum uric acid level (RR 1.06, 95% CI: 1.04-1.07). Uric Acid 109-118 ribonucleotide reductase catalytic subunit M1 Homo sapiens 126-130
23852596-6 2013 More specifically, protocols are described for the preparation and differentiation of BMDCs, their priming and stimulation using particulate NLRP3 agonists such as monosodium urate monohydrate (MSU) and the vaccine adjuvant alum. Uric Acid 164-192 NLR family, pyrin domain containing 3 Mus musculus 141-146
23852596-6 2013 More specifically, protocols are described for the preparation and differentiation of BMDCs, their priming and stimulation using particulate NLRP3 agonists such as monosodium urate monohydrate (MSU) and the vaccine adjuvant alum. Uric Acid 194-197 NLR family, pyrin domain containing 3 Mus musculus 141-146
23852607-1 2013 Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1alpha, and processing of IL-1beta. Uric Acid 29-45 caspase 1 Homo sapiens 113-122
23852607-1 2013 Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1alpha, and processing of IL-1beta. Uric Acid 29-45 interleukin 1 alpha Homo sapiens 137-146
23852607-1 2013 Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1alpha, and processing of IL-1beta. Uric Acid 29-45 interleukin 1 beta Homo sapiens 166-174
22945591-6 2013 The inflammatory component of these immune responses is caused when urate crystals trigger both inflammasome-dependent and independent pathways to generate the proinflammatory cytokine IL-1. Uric Acid 68-73 interleukin 1 alpha Homo sapiens 185-189
23409162-7 2013 Serum urate correlated with angiopoietin-2 levels in dialysis patients and addition of uric acid was able to induce rapid release of angiopoietin-2 from cultured endothelial cells. Uric Acid 6-11 angiopoietin 2 Homo sapiens 28-42
23409162-7 2013 Serum urate correlated with angiopoietin-2 levels in dialysis patients and addition of uric acid was able to induce rapid release of angiopoietin-2 from cultured endothelial cells. Uric Acid 87-96 angiopoietin 2 Homo sapiens 133-147
23409162-9 2013 The possibility that the release of angiopoietin-2 from endothelia is mediated by urate should be explored further. Uric Acid 82-87 angiopoietin 2 Homo sapiens 36-50
23405174-4 2013 We determined that P. falciparum-derived uric acid precipitates induce maturation of human dendritic cells, increasing the expression of cell surface co-stimulatory molecules such as CD80 and CD86, while decreasing human leukocyte antigen-DR expression. Uric Acid 41-50 CD86 molecule Homo sapiens 192-196
22212408-0 2013 Effects of SLC2A9 variants on uric acid levels in a Korean population. Uric Acid 30-39 solute carrier family 2 member 9 Homo sapiens 11-17
23349902-8 2013 In children with UM, UA levels correlate with parasite density (r = 0.092, p = 0.043), sICAM-1 (r = 0.255, p<0.0001) and sTM (r = 0.175, p = 0.0001) levels. Uric Acid 21-23 sulfotransferase family 1A member 3 Homo sapiens 124-127
23349902-9 2013 After adjusting for parasite density, UA levels predict sTM levels. Uric Acid 38-40 sulfotransferase family 1A member 3 Homo sapiens 56-59
23349902-12 2013 UA-induced shedding of endothelial TM may represent a novel mechanism of malaria pathogenesis, in which activated thrombin induces fibrin deposition and platelet aggregation in microvessels. Uric Acid 0-2 coagulation factor II, thrombin Homo sapiens 114-122
23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 interleukin 6 Homo sapiens 77-81
23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 tumor necrosis factor Homo sapiens 131-140
23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 intercellular adhesion molecule 1 Homo sapiens 164-170
23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 vascular cell adhesion molecule 1 Homo sapiens 199-205
22212408-2 2013 Genome-wide association studies have identified several candidate genes associated with serum uric acid levels, including SLC2A9. Uric Acid 94-103 solute carrier family 2 member 9 Homo sapiens 122-128
22212408-6 2013 The top single nucleotide polymorphism associated with uric acid levels was rs4529048 in the SLC2A9 gene on chromosome 4 (P = 2.12 x 10(-6) in the Seoul City sample; P = 1.55 x 10(-9) in the Bundang-Gu sample). Uric Acid 55-64 solute carrier family 2 member 9 Homo sapiens 93-99
22212408-8 2013 This study demonstrates that genetic variants in SLC2A9 influence uric acid levels in Korean adults. Uric Acid 66-75 solute carrier family 2 member 9 Homo sapiens 49-55
22975466-0 2012 Relation of uric acid to serum levels of high-sensitivity C-reactive protein, triglycerides, and high-density lipoprotein cholesterol and to hepatic steatosis. Uric Acid 12-21 C-reactive protein Homo sapiens 58-76
23774753-2 2013 We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. Uric Acid 109-118 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 46-51
24261230-6 2013 RESULTS: The entire patient group showed a positive correlation between C-reactive protein (CRP) and serum uric acid (SUA) (r = 0.27; p < 0.01), suggesting that the nonspecific inflammatory processes were associated with uric acid levels in patients with HD. Uric Acid 107-116 C-reactive protein Homo sapiens 72-90
24261230-6 2013 RESULTS: The entire patient group showed a positive correlation between C-reactive protein (CRP) and serum uric acid (SUA) (r = 0.27; p < 0.01), suggesting that the nonspecific inflammatory processes were associated with uric acid levels in patients with HD. Uric Acid 107-116 C-reactive protein Homo sapiens 92-95
23651970-5 2013 The UA level and the HUA prevalence rate presented a "J" curve relationship with aging and positively correlated with BMI, SBP, DBP, TG, LDL-C, TC and FPG while negatively correlated with HDL-C. Uric Acid 4-6 selenium binding protein 1 Homo sapiens 123-126
23651970-5 2013 The UA level and the HUA prevalence rate presented a "J" curve relationship with aging and positively correlated with BMI, SBP, DBP, TG, LDL-C, TC and FPG while negatively correlated with HDL-C. Uric Acid 4-6 D-box binding PAR bZIP transcription factor Homo sapiens 128-131
23651970-5 2013 The UA level and the HUA prevalence rate presented a "J" curve relationship with aging and positively correlated with BMI, SBP, DBP, TG, LDL-C, TC and FPG while negatively correlated with HDL-C. Uric Acid 4-6 component of oligomeric golgi complex 2 Homo sapiens 137-142
23328510-9 2012 Independent t-test results indicated that the patients with a higher level of uric acid were apt to have a worse WHO-FC, and the higher level uric acid group (serum uric acid > 416.5 micromol/L) had a relative higher level of WHO-FC, NT-proBNP and endothelin-1. Uric Acid 142-151 endothelin 1 Homo sapiens 251-263
23328510-9 2012 Independent t-test results indicated that the patients with a higher level of uric acid were apt to have a worse WHO-FC, and the higher level uric acid group (serum uric acid > 416.5 micromol/L) had a relative higher level of WHO-FC, NT-proBNP and endothelin-1. Uric Acid 142-151 endothelin 1 Homo sapiens 251-263
20593206-10 2012 Spearman"s correlation analysis showed that the Gensini"s score was significantly positively correlated with UAER, sex, age, BMI, SBP, the history of smoking and drinking, the duration of diabetes mellitus, HbA1c, FPG, PPG, LDL-C, Cre, C-reactive protein (CRP), uric acid (UA). Uric Acid 109-111 serglycin Homo sapiens 219-222
20593206-10 2012 Spearman"s correlation analysis showed that the Gensini"s score was significantly positively correlated with UAER, sex, age, BMI, SBP, the history of smoking and drinking, the duration of diabetes mellitus, HbA1c, FPG, PPG, LDL-C, Cre, C-reactive protein (CRP), uric acid (UA). Uric Acid 109-111 C-reactive protein Homo sapiens 236-254
20593206-10 2012 Spearman"s correlation analysis showed that the Gensini"s score was significantly positively correlated with UAER, sex, age, BMI, SBP, the history of smoking and drinking, the duration of diabetes mellitus, HbA1c, FPG, PPG, LDL-C, Cre, C-reactive protein (CRP), uric acid (UA). Uric Acid 109-111 C-reactive protein Homo sapiens 256-259
23020656-2 2012 AREAS COVERED: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Uric Acid 91-93 insulin Homo sapiens 15-22
23380985-7 2012 CIMT was positively correlated with age, creatinine, uric acid, triglyceride, PTX-3, hs-CRP, and NLR, and negatively correlated with estimated glomerular filtration rate in all participants. Uric Acid 53-62 CIMT Homo sapiens 0-4
23020656-2 2012 AREAS COVERED: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Uric Acid 216-218 insulin Homo sapiens 15-22
23126250-9 2012 One such promising drug is lesinurad that decreases serum urate through inhibition of the uric acid transporter (URAT1) in the proximal tubule of the kidney. Uric Acid 58-63 solute carrier family 22 member 12 Homo sapiens 113-118
22658375-1 2012 Acute synovitis induced by deposition of calcium pyrophosphate (CPP) and monosodium urate crystals involves interleukin-1beta production and activation. Uric Acid 73-89 interleukin 1 beta Homo sapiens 108-125
24757603-8 2012 Age, gender, arterial hypertension, estimated glomerular filtration rate (eGFR), uric acid, total cholesterol, and LDL-cholesterol correlated with B2M in the univariate analysis. Uric Acid 81-90 beta-2-microglobulin Homo sapiens 147-150
24757603-9 2012 In the final linear regression model, eGFR, uric acid and total cholesterol correlated independently with B2M (P<0.01). Uric Acid 44-53 beta-2-microglobulin Homo sapiens 106-109
23094836-0 2012 Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson"s disease: linking to Akt/GSK3beta signaling pathway. Uric Acid 19-24 AKT serine/threonine kinase 1 Rattus norvegicus 89-92
23094836-0 2012 Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson"s disease: linking to Akt/GSK3beta signaling pathway. Uric Acid 19-24 glycogen synthase kinase 3 beta Rattus norvegicus 93-101
23094836-8 2012 Similarly, in vitro findings showed that UA alleviated the decrease in Akt activation and the increase in GSK3beta activity caused by 6-OHDA. Uric Acid 41-43 AKT serine/threonine kinase 1 Rattus norvegicus 71-74
23094836-8 2012 Similarly, in vitro findings showed that UA alleviated the decrease in Akt activation and the increase in GSK3beta activity caused by 6-OHDA. Uric Acid 41-43 glycogen synthase kinase 3 beta Rattus norvegicus 106-114
23094836-9 2012 Furthermore, neuroprotection by urate and its regulation on GSK3beta phosphorylation at Ser9 was found to be abolished in the presence of PI3K inhibitor. Uric Acid 32-37 glycogen synthase kinase 3 beta Rattus norvegicus 60-68
23094836-10 2012 Therefore, our findings demonstrated that urate was able to protect dopaminergic neurons in rat nigrostriatal pathway against the neurotoxicity of 6-OHDA, and showed that its beneficial effects may be related to its regulation on Akt/GSK3beta signaling. Uric Acid 42-47 AKT serine/threonine kinase 1 Rattus norvegicus 230-233
23094836-10 2012 Therefore, our findings demonstrated that urate was able to protect dopaminergic neurons in rat nigrostriatal pathway against the neurotoxicity of 6-OHDA, and showed that its beneficial effects may be related to its regulation on Akt/GSK3beta signaling. Uric Acid 42-47 glycogen synthase kinase 3 beta Rattus norvegicus 234-242
23089270-6 2012 Many transport proteins are candidate participants in urate handling, with URAT1 and GLUT9 being the best characterized to date. Uric Acid 54-59 solute carrier family 22 member 12 Homo sapiens 75-80
23127592-9 2012 PWV values gradually increased and adiponectin level decreased with uric acid tertiles. Uric Acid 68-77 adiponectin, C1Q and collagen domain containing Homo sapiens 35-46
23127592-10 2012 Serum uric acid levels in postmenopausal women correlated significantly with age, BMI, WC, TG, HDL-C, insulin, HOMA-IR, adiponectin and PWV. Uric Acid 6-15 insulin Homo sapiens 102-109
23127592-10 2012 Serum uric acid levels in postmenopausal women correlated significantly with age, BMI, WC, TG, HDL-C, insulin, HOMA-IR, adiponectin and PWV. Uric Acid 6-15 adiponectin, C1Q and collagen domain containing Homo sapiens 120-131
23127592-13 2012 CONCLUSIONS: These findings indicate that serum uric acid is independently associated with adiponectin and arterial stiffness in postmenopausal women. Uric Acid 48-57 adiponectin, C1Q and collagen domain containing Homo sapiens 91-102
23203137-1 2012 Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O(2). Uric Acid 99-108 xanthine dehydrogenase Homo sapiens 0-23
23203137-1 2012 Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O(2). Uric Acid 99-108 xanthine dehydrogenase Homo sapiens 25-28
23089270-6 2012 Many transport proteins are candidate participants in urate handling, with URAT1 and GLUT9 being the best characterized to date. Uric Acid 54-59 solute carrier family 2 member 9 Homo sapiens 85-90
23089272-3 2012 Results from animal models suggest a 2-phase mechanism for the development of hyperuricemic hypertension in which uric acid induces acute vasoconstriction by activation of renin-angiotensin system, followed by uric acid uptake into vascular smooth muscle cells leading to cellular proliferation and secondary arteriolosclerosis that impairs pressure natriuresis. Uric Acid 114-123 renin Homo sapiens 172-177
23229602-4 2012 Also fructose raises the uric acid concentration as a result of the activation of fructokinase with ATP consumption and stimulation of AP deaminase. Uric Acid 25-34 ketohexokinase Homo sapiens 82-94
23091148-1 2012 The purpose of these studies was to determine the effects of uric acid (UA) and inosine administration on xanthine oxidoreductase activity in broilers. Uric Acid 61-70 xanthine dehydrogenase Homo sapiens 106-129
23091148-1 2012 The purpose of these studies was to determine the effects of uric acid (UA) and inosine administration on xanthine oxidoreductase activity in broilers. Uric Acid 72-74 xanthine dehydrogenase Homo sapiens 106-129
23059822-4 2012 Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels. Uric Acid 19-28 interleukin 1 beta Homo sapiens 153-170
23059822-4 2012 Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels. Uric Acid 19-28 interleukin 1 beta Homo sapiens 172-180
22893889-4 2012 Therefore, the luminescence intensity depended on the concentration of H(2)O(2) and H(2)O(2)-related reactants, and the detection limits for H(2)O(2), uric acid and cholesterol were 0.20 muM, 0.46 muM and 1.25 muM, respectively. Uric Acid 151-160 latexin Homo sapiens 187-190
22893889-4 2012 Therefore, the luminescence intensity depended on the concentration of H(2)O(2) and H(2)O(2)-related reactants, and the detection limits for H(2)O(2), uric acid and cholesterol were 0.20 muM, 0.46 muM and 1.25 muM, respectively. Uric Acid 151-160 latexin Homo sapiens 197-200
22893889-4 2012 Therefore, the luminescence intensity depended on the concentration of H(2)O(2) and H(2)O(2)-related reactants, and the detection limits for H(2)O(2), uric acid and cholesterol were 0.20 muM, 0.46 muM and 1.25 muM, respectively. Uric Acid 151-160 latexin Homo sapiens 197-200
22866969-7 2012 Multiple linear regression analyses for resistin showed that the resistin levels (beta=0.124, P<0.001) were independently and significantly associated with HOMA-IR as well as body mass index (BMI), alcohol consumption, smoking status, uric acid, gamma-glutamyltransferase (GGT), and high molecular weight (HMW) adiponectin only in men and not in women. Uric Acid 238-247 resistin Homo sapiens 65-73
22632542-5 2012 RESULTS: Colchicine significantly modulated monosodium urate-induced IL-1beta release, LPS-stimulated LDH release, and basal transcript levels of TNF-alpha and IL-6 in healthy controls and BD colchicine responders, but not in BD colchicine nonresponders. Uric Acid 44-60 interleukin 1 beta Homo sapiens 69-77
22671773-9 2012 Transgenic expression of uricase reduced urate accumulation in astrocytes and attenuated the protective influence of urate on dopaminergic cells. Uric Acid 41-46 urate oxidase (pseudogene) Homo sapiens 25-32
22671773-9 2012 Transgenic expression of uricase reduced urate accumulation in astrocytes and attenuated the protective influence of urate on dopaminergic cells. Uric Acid 117-122 urate oxidase (pseudogene) Homo sapiens 25-32
22866969-8 2012 The interaction between gender and resistin level (F=11.50, P<0.001) was also a significant and independent determinant for HOMA-IR as well as gender, BMI, alcohol consumption, smoking status, uric acid, GGT, HMW adiponectin, and resistin. Uric Acid 196-205 resistin Homo sapiens 35-43
22841915-10 2012 OAT4, OAT10, and URAT1 in the apical membrane contribute to proximal tubular urate absorption, and OAT10 to nicotinate absorption. Uric Acid 77-82 solute carrier family 22 member 9 Homo sapiens 0-4
22945592-4 2012 For example, the urate transporter genes SLC2A9, ABCG2 and SLC22A12 modulate serum uric acid levels and gout risk. Uric Acid 83-92 solute carrier family 2 member 9 Homo sapiens 41-47
22945592-4 2012 For example, the urate transporter genes SLC2A9, ABCG2 and SLC22A12 modulate serum uric acid levels and gout risk. Uric Acid 83-92 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 49-54
22945592-4 2012 For example, the urate transporter genes SLC2A9, ABCG2 and SLC22A12 modulate serum uric acid levels and gout risk. Uric Acid 83-92 solute carrier family 22 member 12 Homo sapiens 59-67
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 30-35 solute carrier family 2 member 9 Homo sapiens 151-157
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 30-35 solute carrier family 22 member 12 Homo sapiens 162-170
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 217-222 solute carrier family 2 member 9 Homo sapiens 151-157
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 217-222 solute carrier family 22 member 12 Homo sapiens 162-170
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 217-222 solute carrier family 2 member 9 Homo sapiens 151-157
22945592-5 2012 The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced urate absorption and unopposed urate secretion. Uric Acid 217-222 solute carrier family 22 member 12 Homo sapiens 162-170
22841915-10 2012 OAT4, OAT10, and URAT1 in the apical membrane contribute to proximal tubular urate absorption, and OAT10 to nicotinate absorption. Uric Acid 77-82 solute carrier family 22 member 13 Homo sapiens 6-11
22841915-10 2012 OAT4, OAT10, and URAT1 in the apical membrane contribute to proximal tubular urate absorption, and OAT10 to nicotinate absorption. Uric Acid 77-82 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 17-22
22726397-0 2012 Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 117-122
22678977-1 2012 Xanthine dehydrogenase (XDH), also known as xanthine oxidoreductase (XOR), has long been recognized as the key enzyme in the catabolism of purines, oxidizing hypoxanthine into xanthine and then xanthine into uric acid. Uric Acid 208-217 xanthine dehydrogenase Homo sapiens 0-22
22678977-1 2012 Xanthine dehydrogenase (XDH), also known as xanthine oxidoreductase (XOR), has long been recognized as the key enzyme in the catabolism of purines, oxidizing hypoxanthine into xanthine and then xanthine into uric acid. Uric Acid 208-217 xanthine dehydrogenase Homo sapiens 24-27
22678977-1 2012 Xanthine dehydrogenase (XDH), also known as xanthine oxidoreductase (XOR), has long been recognized as the key enzyme in the catabolism of purines, oxidizing hypoxanthine into xanthine and then xanthine into uric acid. Uric Acid 208-217 xanthine dehydrogenase Homo sapiens 44-67
22678977-1 2012 Xanthine dehydrogenase (XDH), also known as xanthine oxidoreductase (XOR), has long been recognized as the key enzyme in the catabolism of purines, oxidizing hypoxanthine into xanthine and then xanthine into uric acid. Uric Acid 208-217 xanthine dehydrogenase Homo sapiens 69-72
22726397-0 2012 Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome. Uric Acid 18-21 NLR family pyrin domain containing 3 Homo sapiens 117-122
26558034-7 2012 (i) Abdominal obesity predisposes to insulin resistance, which at the renal level causes reduced urinary ammonium excretion and thus a low urinary pH; the consequence is a greater risk of uric acid stone formation. Uric Acid 188-197 insulin Homo sapiens 37-44
22904305-5 2012 In a second model of IL-1beta-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6. Uric Acid 71-87 interleukin 1 beta Mus musculus 21-29
22904305-5 2012 In a second model of IL-1beta-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6. Uric Acid 71-87 NLR family, pyrin domain containing 3 Mus musculus 51-56
22904305-5 2012 In a second model of IL-1beta-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6. Uric Acid 71-87 interleukin 6 Mus musculus 117-121
22883806-0 2012 Re: Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Uric Acid 4-13 aryl-hydrocarbon receptor Mus musculus 47-72
22272940-6 2012 Univariate analysis revealed a strong linear correlation of visfatin levels with systolic (r=0.505, p<0.001), diastolic (r=0.467, p<0.001) and mean arterial blood pressure (r=0.497, p<0.001), as well as with uric acid concentrations in the serum (r=0.463, p<0.001). Uric Acid 217-226 nicotinamide phosphoribosyltransferase Homo sapiens 60-68
22883806-0 2012 Re: Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Uric Acid 4-13 aryl-hydrocarbon receptor Mus musculus 74-77
22745932-5 2012 Based on the principle for determination of H(2)O(2), we developed a new strategy for assay of glucose and uric acid by coupling with glucose oxidase (GOx)-mediated and uricase-mediated reaction. Uric Acid 107-116 hydroxyacid oxidase 1 Homo sapiens 134-149
22974665-5 2012 Multivariate analysis showed that waist circumference, BMI, serum uric acid, blood sugar, and triglyceride levels were related to abnormal AST and ALT (p<0.05), but the odds ratio for waist circumference was larger than that for BMI. Uric Acid 66-75 solute carrier family 17 member 5 Homo sapiens 139-142
22974665-6 2012 In conclusion, waist circumference, BMI, serum uric acid, blood sugar, and triglyceride levels are important risk factors for abnormal AST and ALT readings in Taiwanese adults. Uric Acid 47-56 solute carrier family 17 member 5 Homo sapiens 135-138
26894025-3 2012 Herein, we investigated the clinical significance of uric acid level at the time of biopsy, as a marker of IgAN progression. Uric Acid 53-62 IGAN1 Homo sapiens 107-111
22520641-9 2012 RESULTS: US-FLI showed a positive correlation with HOMA, insulin, uric acid, ferritin, ALT and bilirubin and was associated with steatosis extent assessed histologically and histological features of NASH, except for fibrosis. Uric Acid 66-75 FLII actin remodeling protein Homo sapiens 12-15
22745932-5 2012 Based on the principle for determination of H(2)O(2), we developed a new strategy for assay of glucose and uric acid by coupling with glucose oxidase (GOx)-mediated and uricase-mediated reaction. Uric Acid 107-116 hydroxyacid oxidase 1 Homo sapiens 151-154
22647630-3 2012 Addition of urate to SLC2A9-producing oocytes generated outward currents, indicating electrogenic transport. Uric Acid 12-17 solute carrier family 2 member 9 Homo sapiens 21-27
22647630-4 2012 Urate transport by SLC2A9 was voltage dependent and independent of the Na(+) transmembrane gradient. Uric Acid 0-5 solute carrier family 2 member 9 Homo sapiens 19-25
22647630-6 2012 [(14)C]urate flux studies under non-voltage-clamped conditions demonstrated symmetry of influx and efflux, suggesting that SLC2A9 functions in urate efflux driven primarily by the electrochemical gradient of the cell. Uric Acid 7-12 solute carrier family 2 member 9 Homo sapiens 123-129
22647630-6 2012 [(14)C]urate flux studies under non-voltage-clamped conditions demonstrated symmetry of influx and efflux, suggesting that SLC2A9 functions in urate efflux driven primarily by the electrochemical gradient of the cell. Uric Acid 143-148 solute carrier family 2 member 9 Homo sapiens 123-129
22647630-9 2012 SLC2A9 mediated the uptake of adenine in addition to urate, but did not function as a generalized nucleobase transporter. Uric Acid 53-58 solute carrier family 2 member 9 Homo sapiens 0-6
22647630-10 2012 The differential expression pattern of the two isoforms of SLC2A9 in the human kidney"s proximal convoluted tubule and its electrogenic transport of urate suggest that these transporters play key roles in the regulation of plasma urate levels and are therefore potentially important participants in hyperuricemia and hypouricemia. Uric Acid 149-154 solute carrier family 2 member 9 Homo sapiens 59-65
22476232-5 2012 Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (beta=0.16), male gender (beta=-0.267), homeostasis model assessment of insulin resistance (beta=-0.140) and the plasma levels of high-density lipoprotein cholesterol (beta=0.104), uric acid (beta=-0.13), triglycerides (beta=-0.169) and brain natriuretic peptide (beta=0.151). Uric Acid 300-309 adiponectin, C1Q and collagen domain containing Homo sapiens 38-49
23030062-3 2012 In the presence of phosphate, PNPase catalyzes the phosphorolysis of inosine, generating hypoxanthine, which is oxidized to uric acid by XOD. Uric Acid 124-133 purine nucleoside phosphorylase Homo sapiens 30-36
22554475-3 2012 Treatment of hens with CORT stimulated an increase (P<0.05) in plasma CORT, glucose, uric acid (UA), insulin, cholesterol (Chol) and triiodothyronine (T(3)), but the concentrations of plasma non-esterified fatty acids (NEFA) and triacylglycerol (TG) were decreased (P<0.05). Uric Acid 88-97 CORT Gallus gallus 23-27
22554475-3 2012 Treatment of hens with CORT stimulated an increase (P<0.05) in plasma CORT, glucose, uric acid (UA), insulin, cholesterol (Chol) and triiodothyronine (T(3)), but the concentrations of plasma non-esterified fatty acids (NEFA) and triacylglycerol (TG) were decreased (P<0.05). Uric Acid 99-101 CORT Gallus gallus 23-27
22753829-4 2012 During the follow-up period (through 2001), the incidence rates of diabetes and prediabetes (insulin resistance and impaired fasting glucose) were higher among persons with greater serum urate concentrations. Uric Acid 187-192 insulin Homo sapiens 93-100
21544634-0 2012 G109T polymorphism of SLC22A12 gene is associated with serum uric acid level, but not with metabolic syndrome. Uric Acid 61-70 solute carrier family 22 member 12 Homo sapiens 22-30
21544634-1 2012 SLC22A12 gene, encoding urate transport 1, has been known to be responsible to urate metabolism. Uric Acid 24-29 solute carrier family 22 member 12 Homo sapiens 0-8
21544634-2 2012 This study sought to determine the association between the novel G109T polymorphism in SLC22A12 with serum uric acid and the development of metabolic syndrome in Korean male subjects. Uric Acid 107-116 solute carrier family 22 member 12 Homo sapiens 87-95
21544634-12 2012 The novel G109T polymorphism of the SLC22A12 gene is related to serum uric acid level, but not to the development of metabolic syndrome. Uric Acid 70-79 solute carrier family 22 member 12 Homo sapiens 36-44
22762240-0 2012 Enhanced interleukin-1beta production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals. Uric Acid 127-132 interleukin 1 beta Homo sapiens 9-26
22565184-0 2012 Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population. Uric Acid 90-99 LDL receptor related protein 2 Homo sapiens 32-36
22565184-1 2012 A genome-wide association study identified that LRP2 rs2544390 in intron 1 was associated with serum uric acid (SUA) levels among Japanese, as well as polymorphisms of SLC22A12, ABCG2, and SLC2A9. Uric Acid 101-110 LDL receptor related protein 2 Homo sapiens 48-52
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 PDZ domain containing 1 Homo sapiens 64-69
22426011-7 2012 The NLRP3 inflammasome may be the target mediating the improvement of urate-lowering agents allopurinol, quercetin and rutin on fructose-induced renal lipid accumulation and injury. Uric Acid 70-75 NLR family, pyrin domain containing 3 Rattus norvegicus 4-9
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 glucokinase regulator Homo sapiens 71-75
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 solute carrier family 2 member 9 Homo sapiens 77-83
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 85-90
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 capping protein regulator and myosin 1 linker 1 Homo sapiens 92-99
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 solute carrier family 17 member 3 Homo sapiens 101-108
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 solute carrier family 16 member 9 Homo sapiens 110-117
23534271-6 2012 Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. Uric Acid 53-62 solute carrier family 22 member 12 Homo sapiens 122-130
27790013-3 2012 Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol that catalyzes the oxidation of uric acid into allantoin, a more soluble end product. Uric Acid 113-122 urate oxidase (pseudogene) Homo sapiens 39-46
22311343-0 2012 Uric acid and IGF1 as possible determinants of FGF23 metabolism in children with normal renal function. Uric Acid 0-9 fibroblast growth factor 23 Homo sapiens 47-52
22311343-4 2012 RESULTS: In bivariate analyses, C-terminal FGF23 levels were positively related to phosphorus and uric acid levels. Uric Acid 98-107 fibroblast growth factor 23 Homo sapiens 43-48
22311343-5 2012 Intact FGF23 levels were positively associated with uric acid and insulin growth factor 1 (IGF1) levels, with similar results for age, body mass index (BMI), and 25OH vitamin D (25(OH)D). Uric Acid 52-61 fibroblast growth factor 23 Homo sapiens 7-12
22311343-7 2012 CONCLUSIONS: In children with preserved kidney function, the association between FGF23, uric acid, and IGF1 suggests that FGF23 could be an early nutritional indicator of high protein and phosphate intake. Uric Acid 88-97 fibroblast growth factor 23 Homo sapiens 122-127
26105343-11 2012 Serum levels of PIGF were significantly lower in preeclamptic women with serum uric acid level >=6mg/dL compared with women with serum uric acid <6mg/dL (median 48.46 vs 117.32pg/mL). Uric Acid 79-88 phosphatidylinositol glycan anchor biosynthesis class F Homo sapiens 16-20
26105384-10 2012 RESULTS: Hsp70 levels obtained from early-onset PE group were significantly higher than the late-onset PE women and showed positive correlation with uric acid (r=0.4547; p=0.0028). Uric Acid 149-158 heat shock protein family A (Hsp70) member 4 Homo sapiens 9-14
26105384-14 2012 CONCLUSION: Association between levels of Hsp70 and uric acid in plasma of patients with early-onset PE seems to reflect the oxidative stress in this group of patients. Uric Acid 52-61 heat shock protein family A (Hsp70) member 4 Homo sapiens 42-47
27790013-2 2012 Uric acid is the end product of purine metabolism in humans because the gene encoding uricase was lost during hominoid evolution. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 86-93
22946216-5 2012 In groups with higher content of uric acid, the significant difference between median and quartiles was determined concerning the indicators of height, body mass, triglycerides concentration, beta-lipoprotein fractions content, pre beta-lipoprotein fractions content, apolipoprotein E in blood serum and apolipoprotein B=100 lipoproteins, but not both apolipoprotein C=III and apolipoprotein E in lipoproteins of high density. Uric Acid 33-42 apolipoprotein E Homo sapiens 268-284
22275296-8 2012 Following treatment with SMP/GMP/G600 over the 3-month period, greater improvements were also observed in pain and fractional excretion of uric acid, with trends to greater improvement in tender joint count. Uric Acid 139-148 family with sequence similarity 53 member B Homo sapiens 25-37
22127401-3 2012 RESULTS: The serum level of cystatin C was positively correlated with age (P < 0.001), duration of diabetes (P = 0.013), serum creatinine (P < 0.001), uric acid (P < 0.001), and adiponectin (p = 0.001), while it was inversely correlated with estimated glomerular filtration rate (P < 0.001). Uric Acid 157-166 cystatin C Homo sapiens 28-38
22672087-5 2012 Initially, uric acid induces vasoconstriction by activation of the renin-angiotensin system and reduction of circulating nitric oxide, which can be reversed by lowering uric acid. Uric Acid 11-20 renin Homo sapiens 67-72
22770406-9 2012 MS patients with lower serum UA levels tended to have higher white blood cell counts and myelin basic protein level. Uric Acid 29-31 myelin basic protein Homo sapiens 89-109
21830843-8 2012 RESULTS: Anti-ICAM-1 mAb significantly decreased the levels of blood pressure, urinary protein, maternal BUN, creatnine and uric acid comparing with untreated preeclamptic rats. Uric Acid 124-133 intercellular adhesion molecule 1 Rattus norvegicus 14-20
22543043-7 2012 UA significantly decreased over time in control neonates but remained stable in TDP neonates (132.76 to 123.23 muM versus 140.50 to 138.9 muM; P = .002). Uric Acid 0-2 latexin Homo sapiens 111-114
22543043-7 2012 UA significantly decreased over time in control neonates but remained stable in TDP neonates (132.76 to 123.23 muM versus 140.50 to 138.9 muM; P = .002). Uric Acid 0-2 latexin Homo sapiens 138-141
22946216-5 2012 In groups with higher content of uric acid, the significant difference between median and quartiles was determined concerning the indicators of height, body mass, triglycerides concentration, beta-lipoprotein fractions content, pre beta-lipoprotein fractions content, apolipoprotein E in blood serum and apolipoprotein B=100 lipoproteins, but not both apolipoprotein C=III and apolipoprotein E in lipoproteins of high density. Uric Acid 33-42 apolipoprotein B Homo sapiens 304-324
22946216-5 2012 In groups with higher content of uric acid, the significant difference between median and quartiles was determined concerning the indicators of height, body mass, triglycerides concentration, beta-lipoprotein fractions content, pre beta-lipoprotein fractions content, apolipoprotein E in blood serum and apolipoprotein B=100 lipoproteins, but not both apolipoprotein C=III and apolipoprotein E in lipoproteins of high density. Uric Acid 33-42 apolipoprotein C3 Homo sapiens 352-372
22932106-9 2012 (5) In preeclampsia, serum LCN-2 level significant associated with 24 hours total urinary protein and uric acid (r = 0.565, 0.476, P < 0.01). Uric Acid 102-111 lipocalin 2 Homo sapiens 27-32
22946216-5 2012 In groups with higher content of uric acid, the significant difference between median and quartiles was determined concerning the indicators of height, body mass, triglycerides concentration, beta-lipoprotein fractions content, pre beta-lipoprotein fractions content, apolipoprotein E in blood serum and apolipoprotein B=100 lipoproteins, but not both apolipoprotein C=III and apolipoprotein E in lipoproteins of high density. Uric Acid 33-42 apolipoprotein E Homo sapiens 377-393
22588836-9 2012 Furthermore, we found tanshinone IIA alone could also inhibit urate-induced MCP-1 and IL-1beta overexpression both in vivo and in vitro, accompanied with inhibition of NF-kappaB translocation from cytosome to nucleus. Uric Acid 62-67 mast cell protease 1-like 1 Rattus norvegicus 76-81
22588836-9 2012 Furthermore, we found tanshinone IIA alone could also inhibit urate-induced MCP-1 and IL-1beta overexpression both in vivo and in vitro, accompanied with inhibition of NF-kappaB translocation from cytosome to nucleus. Uric Acid 62-67 interleukin 1 beta Rattus norvegicus 86-94
21932115-2 2012 In the National Health and Nutrition Examination Survey (NHANES), numerous factors not classically associated with calcium-phosphorus homeostasis, such as uric acid and smoking, are independently associated with PTH in adults without chronic kidney disease. Uric Acid 155-164 parathyroid hormone Homo sapiens 212-215
21932115-10 2012 Higher uric acid was associated with higher PTH. Uric Acid 7-16 parathyroid hormone Homo sapiens 44-47
22565176-6 2012 We found strong correlations of cystatin C with creatinine (r = 0.9454), urea (r = 0.8999) and uric acid (r = 0.8325). Uric Acid 95-104 cystatin C Homo sapiens 32-42
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 12-28 interleukin 1 beta Homo sapiens 89-106
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 12-28 interleukin 1 beta Homo sapiens 108-116
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 12-28 NLR family pyrin domain containing 3 Homo sapiens 235-240
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 30-33 interleukin 1 beta Homo sapiens 89-106
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 30-33 interleukin 1 beta Homo sapiens 108-116
22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 30-33 NLR family pyrin domain containing 3 Homo sapiens 235-240
22398104-2 2012 Its immediate precursor, xanthine, is converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric Acid 51-60 xanthine dehydrogenase Homo sapiens 96-119
22366735-1 2012 To investigate whether monosodium urate (MSU) crystals could induce the production of VCAM-1 (vascular cell adhesion molecule 1) in human synovial cells and its possible signaling pathways, human synovial cells isolated from synovial tissue explants were stimulated with various doses of MSU crystals for different time intervals. Uric Acid 23-39 vascular cell adhesion molecule 1 Homo sapiens 98-104
22366735-1 2012 To investigate whether monosodium urate (MSU) crystals could induce the production of VCAM-1 (vascular cell adhesion molecule 1) in human synovial cells and its possible signaling pathways, human synovial cells isolated from synovial tissue explants were stimulated with various doses of MSU crystals for different time intervals. Uric Acid 23-39 vascular cell adhesion molecule 1 Homo sapiens 106-139
22366735-1 2012 To investigate whether monosodium urate (MSU) crystals could induce the production of VCAM-1 (vascular cell adhesion molecule 1) in human synovial cells and its possible signaling pathways, human synovial cells isolated from synovial tissue explants were stimulated with various doses of MSU crystals for different time intervals. Uric Acid 41-44 vascular cell adhesion molecule 1 Homo sapiens 98-104
22366735-1 2012 To investigate whether monosodium urate (MSU) crystals could induce the production of VCAM-1 (vascular cell adhesion molecule 1) in human synovial cells and its possible signaling pathways, human synovial cells isolated from synovial tissue explants were stimulated with various doses of MSU crystals for different time intervals. Uric Acid 41-44 vascular cell adhesion molecule 1 Homo sapiens 106-139
22045201-6 2012 Polymerase chain reaction of a urate anion exchanger known to regulate UA level [SLC22A12 gene: UA transporter 1 (URAT1)] demonstrated compound heterozygous mutations (Q297X and R90H). Uric Acid 71-73 solute carrier family 22 member 12 Homo sapiens 81-89
22712045-9 2012 RESULTS: The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, gamma-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. Uric Acid 102-111 C-reactive protein Homo sapiens 383-401
22473008-5 2012 Paradoxically, ABCG2 export dysfunction significantly increases urinary urate excretion and risk ratio of urate overproduction. Uric Acid 72-77 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 15-20
22473008-5 2012 Paradoxically, ABCG2 export dysfunction significantly increases urinary urate excretion and risk ratio of urate overproduction. Uric Acid 106-111 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 15-20
22473008-6 2012 Abcg2-knockout mice show increased serum uric acid levels and renal urate excretion, and decreased intestinal urate excretion. Uric Acid 41-50 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-5
22237152-10 2012 Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Uric Acid 13-22 C-reactive protein Homo sapiens 73-91
22237152-10 2012 Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Uric Acid 13-22 C-reactive protein Homo sapiens 93-96
22237152-12 2012 CONCLUSION: Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation. Uric Acid 27-36 superoxide dismutase 2 Homo sapiens 145-150
22516999-12 2012 (4) In the patients with gouty arthritis, there was a positive correlation between DKK-1 and TRAP5b(r=0.47, P<0.001), while the levels of DKK-1 were not related with age, disease duration, body mass index or serum uric acid(r=-0.153, -0.123, 0.158, 0.00,P=0.126, 0.509, 0.381, 0.926). Uric Acid 217-226 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 83-88
22045201-6 2012 Polymerase chain reaction of a urate anion exchanger known to regulate UA level [SLC22A12 gene: UA transporter 1 (URAT1)] demonstrated compound heterozygous mutations (Q297X and R90H). Uric Acid 71-73 solute carrier family 22 member 12 Homo sapiens 96-112
22045201-6 2012 Polymerase chain reaction of a urate anion exchanger known to regulate UA level [SLC22A12 gene: UA transporter 1 (URAT1)] demonstrated compound heterozygous mutations (Q297X and R90H). Uric Acid 71-73 solute carrier family 22 member 12 Homo sapiens 114-119
22306318-3 2012 In this study we found that serum uric acid level of Oit3 null mice was significantly lower than that in wild type controls, whereas the excretion of uric acid in urine increased in the mutant mouse. Uric Acid 34-43 oncoprotein induced transcript 3 Mus musculus 53-57
21992452-1 2012 There is an increased prevalence of nephrolithiasis and an increase in the incidence of renal colic in patients with diabetes, obesity, hypertension and insulin resistance because of an increased frequency of uric acid crystallization. Uric Acid 209-218 insulin Homo sapiens 153-160
21992452-3 2012 However, in the presence of insulin resistance, there is decreased renal tubular generation of ammonia and increased sodium absorption leading to acidification of the urine and uric acid crystallization. Uric Acid 177-186 insulin Homo sapiens 28-35
22768707-1 2012 During millions years in all animals allantoine (oxidized by uricase uric acid) was catabolite of purines and ascorbic acid was an acceptor of active forms of oxygen. Uric Acid 69-78 urate oxidase (pseudogene) Homo sapiens 61-68
22768707-3 2012 Later on occurred a second spontaneous mutation and uricase gen minus and uric acid became catabolites of purines. Uric Acid 74-83 urate oxidase (pseudogene) Homo sapiens 52-59
22541106-6 2012 There was positive correlation between serum uric acid and levels of GMP-140, PAF, P-LCR and PDW, respectively (r = 0.667, 0.879, 0.310, 0.460, P < 0.01 or P < 0.05). Uric Acid 45-54 selectin P Homo sapiens 69-76
22541106-6 2012 There was positive correlation between serum uric acid and levels of GMP-140, PAF, P-LCR and PDW, respectively (r = 0.667, 0.879, 0.310, 0.460, P < 0.01 or P < 0.05). Uric Acid 45-54 PCNA clamp associated factor Homo sapiens 78-81
22541106-7 2012 Multivariate stepwise regression analysis revealed that serum uric acid, creatinine, P-LCR, urea nitrogen contributed to GMP-140 level (adjusted R(2) = 0.822). Uric Acid 62-71 selectin P Homo sapiens 121-128
22541106-8 2012 Serum uric acid and LDL-C also contributed to PAF level (adjusted R(2) = 0.451). Uric Acid 6-15 PCNA clamp associated factor Homo sapiens 46-49
22000606-1 2012 Among adolescents, uric acid is associated with insulin resistance, hypertension, and the metabolic syndrome (MetS); and in adults, high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. Uric Acid 19-28 insulin Homo sapiens 48-55
21866382-0 2012 Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. Uric Acid 92-101 insulin Homo sapiens 12-19
22306318-5 2012 Our data suggest that OIT3 could maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with THP. Uric Acid 42-47 oncoprotein induced transcript 3 Mus musculus 22-26
22306318-5 2012 Our data suggest that OIT3 could maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with THP. Uric Acid 108-117 oncoprotein induced transcript 3 Mus musculus 22-26
22189943-2 2012 UA, which is significantly increased in the circulation following renal ischemia-reperfusion injury (IRI), was used both in vitro and in vivo as an early response-signaling molecule to determine its ability to induce the secretion of HMGB1 from endothelial cells. Uric Acid 0-2 high mobility group box 1 Homo sapiens 234-239
22189943-4 2012 Treatment of HUVEC with UA and a calcium mobilization inhibitor (TMB-8) or a MEK/Erk pathway inhibitor (U0126) prevented translocation of HMGB1 from the nucleus, resulting in reduced cytoplasmic and circulating levels of HMGB1. Uric Acid 24-26 high mobility group box 1 Homo sapiens 138-143
22189943-4 2012 Treatment of HUVEC with UA and a calcium mobilization inhibitor (TMB-8) or a MEK/Erk pathway inhibitor (U0126) prevented translocation of HMGB1 from the nucleus, resulting in reduced cytoplasmic and circulating levels of HMGB1. Uric Acid 24-26 high mobility group box 1 Homo sapiens 221-226
22105559-6 2012 IL-1beta release induced by other well-characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors. Uric Acid 100-109 interleukin 1 beta Homo sapiens 0-8
22392103-8 2012 Multiple linear regression analysis using C-IMT as a dependent variable showed that age (beta=0.84, P=0.03) and UA levels (beta=-0.87, P=0.02) were independently associated with C-IMT. Uric Acid 112-114 CIMT Homo sapiens 42-47
22392103-8 2012 Multiple linear regression analysis using C-IMT as a dependent variable showed that age (beta=0.84, P=0.03) and UA levels (beta=-0.87, P=0.02) were independently associated with C-IMT. Uric Acid 112-114 CIMT Homo sapiens 178-183
22229870-8 2012 In addition, we identified several novel loci suggestive of association with uric acid levels (SEMA5A, TMEM18, SLC28A2, and ODZ2), although the P-values (P<5x10(-6)) did not reach the threshold of genome-wide significance. Uric Acid 77-86 semaphorin 5A Homo sapiens 95-101
22229870-8 2012 In addition, we identified several novel loci suggestive of association with uric acid levels (SEMA5A, TMEM18, SLC28A2, and ODZ2), although the P-values (P<5x10(-6)) did not reach the threshold of genome-wide significance. Uric Acid 77-86 transmembrane protein 18 Homo sapiens 103-109
22229870-8 2012 In addition, we identified several novel loci suggestive of association with uric acid levels (SEMA5A, TMEM18, SLC28A2, and ODZ2), although the P-values (P<5x10(-6)) did not reach the threshold of genome-wide significance. Uric Acid 77-86 teneurin transmembrane protein 2 Homo sapiens 124-128
22157498-3 2012 RECENT FINDINGS: The gene SLC2A9 encodes for GLUT9, an important proximal tubule transporter of uric acid. Uric Acid 96-105 solute carrier family 2 member 9 Homo sapiens 26-32
22157498-3 2012 RECENT FINDINGS: The gene SLC2A9 encodes for GLUT9, an important proximal tubule transporter of uric acid. Uric Acid 96-105 solute carrier family 2 member 9 Homo sapiens 45-50
22157498-7 2012 Genetic studies of urate transportation and of uromodulin-related nephropathy emphasize the pivotal importance of the proximal tubule in uric acid homeostasis. Uric Acid 137-146 uromodulin Homo sapiens 47-57
22324836-7 2012 CONCLUSION: Serum high HMW-adipo level was significantly negatively related to the presence of MetS, independently of the serum levels of insulin, liver enzymes and uric acid. Uric Acid 165-174 cilia and flagella associated protein 97 Homo sapiens 23-26
22157498-9 2012 SUMMARY: Renal tubular handling of uric acid is dependent on tubular transporters, one of which is GLUT9. Uric Acid 35-44 solute carrier family 2 member 9 Homo sapiens 99-104
22157498-10 2012 Mutations of its gene SLC2A9 are associated with aberrations of uric acid disposal. Uric Acid 64-73 solute carrier family 2 member 9 Homo sapiens 22-28
22105559-6 2012 IL-1beta release induced by other well-characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors. Uric Acid 100-109 NLR family pyrin domain containing 3 Homo sapiens 53-58
21810765-14 2012 Our findings confirm the pivotal role of GLUT9 in UA transport and highlight the similarities and differences between RHUC1 and RHUC2. Uric Acid 50-52 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 41-46
22189840-3 2012 This gene expresses the GLUT9 transporter that also transports uric acid and is associated with lower serum uric acid levels. Uric Acid 63-72 solute carrier family 2 member 9 Homo sapiens 24-29
22189840-3 2012 This gene expresses the GLUT9 transporter that also transports uric acid and is associated with lower serum uric acid levels. Uric Acid 108-117 solute carrier family 2 member 9 Homo sapiens 24-29
22189840-7 2012 Each copy of the GLUT9 minor Ile allele was found to confer a significant 0.44 mg/dl reduction in serum uric acid and was associated with a significant mean decrease in the systolic blood pressure of 2.2 and 1.5 mm Hg on the high- and low-sodium diet, respectively. Uric Acid 104-113 solute carrier family 2 member 9 Homo sapiens 17-22
22189840-8 2012 Thus, a Mendelian randomization analysis using variants in the GLUT9 gene indicates that a decrease in serum uric acid has a causal effect of lowering blood pressure. Uric Acid 109-118 solute carrier family 2 member 9 Homo sapiens 63-68
22198264-8 2012 Activation of NF-kappaB and SAPK/JNK, ERK1/2 and p38 MAP kinases by MSU crystals in articular chondrocytes and synovial fibroblasts in vitro was attenuated by treatment with PYC. Uric Acid 68-71 mitogen-activated protein kinase 9 Homo sapiens 28-32
22420403-0 2012 Gender-dependent associations of uric acid levels with a polymorphism in SLC2A9 in Han Chinese patients. Uric Acid 33-42 solute carrier family 2 member 9 Homo sapiens 73-79
22198264-8 2012 Activation of NF-kappaB and SAPK/JNK, ERK1/2 and p38 MAP kinases by MSU crystals in articular chondrocytes and synovial fibroblasts in vitro was attenuated by treatment with PYC. Uric Acid 68-71 mitogen-activated protein kinase 8 Homo sapiens 33-36
22198264-8 2012 Activation of NF-kappaB and SAPK/JNK, ERK1/2 and p38 MAP kinases by MSU crystals in articular chondrocytes and synovial fibroblasts in vitro was attenuated by treatment with PYC. Uric Acid 68-71 mitogen-activated protein kinase 3 Homo sapiens 38-44
22198264-8 2012 Activation of NF-kappaB and SAPK/JNK, ERK1/2 and p38 MAP kinases by MSU crystals in articular chondrocytes and synovial fibroblasts in vitro was attenuated by treatment with PYC. Uric Acid 68-71 mitogen-activated protein kinase 1 Homo sapiens 49-52
22198264-9 2012 The acute inflammatory cell infiltration and increased expression of COX-2 and iNOS in synovial tissue and articular cartilage following intra-articular injection of MSU crystals in a rat model was inhibited by coadministration of PYC. Uric Acid 166-169 prostaglandin-endoperoxide synthase 2 Homo sapiens 69-74
22198264-9 2012 The acute inflammatory cell infiltration and increased expression of COX-2 and iNOS in synovial tissue and articular cartilage following intra-articular injection of MSU crystals in a rat model was inhibited by coadministration of PYC. Uric Acid 166-169 nitric oxide synthase 2 Rattus norvegicus 79-83
21842242-5 2012 Moreover, the elevation in uric acid levels observed after fructose ingestion, with a consequent reduction in nitric oxide, may lead to a reduced glucose uptake in the skeletal muscle, hyperinsulinemia, and insulin resistance. Uric Acid 27-36 insulin Homo sapiens 190-197
22038265-5 2012 Although the molecular identification of a kidney-specific urate/anion exchanger URAT1 in 2002 paved the way for successive identification of several urate transport-related proteins, the entire picture of effective renal urate handling in humans has not yet been clarified. Uric Acid 59-64 solute carrier family 22 member 12 Homo sapiens 81-86
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 137-142 solute carrier family 2 member 9 Homo sapiens 90-96
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 137-142 solute carrier family 2 member 9 Homo sapiens 98-103
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 137-142 solute carrier family 2 member 9 Homo sapiens 191-197
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 137-142 solute carrier family 22 member 12 Homo sapiens 328-333
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 173-178 solute carrier family 2 member 9 Homo sapiens 90-96
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 173-178 solute carrier family 2 member 9 Homo sapiens 98-103
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 173-178 solute carrier family 2 member 9 Homo sapiens 191-197
22038265-7 2012 In 2008, we functionally characterized the facilitatory glucose transporter family member SLC2A9 (GLUT9), one of the candidate genes for urate handling, as a voltage-driven urate transporter URATv1 at the basolateral side of renal proximal tubules that comprises the main route of the urate reabsorption pathway, in tandem with URAT1 at the apical side. Uric Acid 173-178 solute carrier family 22 member 12 Homo sapiens 328-333
22246954-1 2012 We identified a novel missense mutation, c.424G>C (p.Val142Leu) in PRPS1 in a patient with uric acid overproduction without gout but with developmental delay, hypotonia, hearing loss, and recurrent respiratory infections. Uric Acid 94-103 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 70-75
22246954-7 2012 Our results show that missense mutations in PRPS1 can cause a continuous spectrum of features ranging from progressive non-syndromic postlingual hearing impairment to uric acid overproduction, neuropathy, and recurrent infections depending on the functional sites that are affected. Uric Acid 167-176 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 44-49
22147847-3 2012 Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1. Uric Acid 120-129 NLR family, pyrin domain containing 3 Mus musculus 146-151
22147847-3 2012 Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1. Uric Acid 120-129 interleukin 1 beta Mus musculus 190-198
22147847-3 2012 Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1. Uric Acid 120-129 interleukin 1 beta Mus musculus 209-217
22147847-3 2012 Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1. Uric Acid 120-129 caspase 1 Mus musculus 226-235
21933003-0 2012 Optimal uric acid threshold to identify insulin resistance in healthy women. Uric Acid 8-17 insulin Homo sapiens 40-47
21933003-2 2012 Our aims were to determine the relationship between uric acid and insulin resistance and to define the optimal uric acid cutoff to identify insulin resistance in women. Uric Acid 111-120 insulin Homo sapiens 140-147
22303532-1 2012 A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease. Uric Acid 79-88 insulin Homo sapiens 163-170
22232670-0 2012 Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Uric Acid 0-9 aryl-hydrocarbon receptor Mus musculus 43-68
22232670-0 2012 Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Uric Acid 0-9 aryl-hydrocarbon receptor Mus musculus 70-73
21613382-9 2012 Serum uric acid was lowered non-significantly with low-fructose diet (7.1 +- 1.3 versus 6.6 +- 1.0 mg/dL, P < 0.1), whereas a significant decrease in fasting serum insulin was observed (11.2 +- 6.1 versus 8.2 +- 2.9 mIU/mL, P < 0.05) and the reduction persisted after return to the regular diet. Uric Acid 6-15 insulin Homo sapiens 167-174
23059997-3 2012 Because of its different catalytic effect towards the electro-oxidation of AA and UA, the PAN-OAP/GCE could resolve the overlapped voltammetric response of AA and UA into two sharp and well-defined voltammetric peaks with both CV and differential pulse voltammetry (DPV), which could be applied for the selective and simultaneous determination of AA and UA in their binary mixture. Uric Acid 82-84 aminomethyltransferase Homo sapiens 90-101
22136504-11 2012 In conclusion, TDF may be associated with subclinical mitochondrial damage, inducing at a later stage increased urinary excretion of phosphate and uric acid, as markers of incipient tubular injury. Uric Acid 147-156 sex determining region Y Homo sapiens 15-18
22265524-3 2012 Voltammetric studies revealed the increased electrochemical activity of the CNP-modified electrode toward various biologically important molecules, including dopamine, uric acid, dihydronicotinamide adenine dinucleotide, tyrosine, and serotonin, relative to those obtained using the unmodified electrode. Uric Acid 168-177 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 76-79
23059997-3 2012 Because of its different catalytic effect towards the electro-oxidation of AA and UA, the PAN-OAP/GCE could resolve the overlapped voltammetric response of AA and UA into two sharp and well-defined voltammetric peaks with both CV and differential pulse voltammetry (DPV), which could be applied for the selective and simultaneous determination of AA and UA in their binary mixture. Uric Acid 163-165 aminomethyltransferase Homo sapiens 90-101
23059997-3 2012 Because of its different catalytic effect towards the electro-oxidation of AA and UA, the PAN-OAP/GCE could resolve the overlapped voltammetric response of AA and UA into two sharp and well-defined voltammetric peaks with both CV and differential pulse voltammetry (DPV), which could be applied for the selective and simultaneous determination of AA and UA in their binary mixture. Uric Acid 163-165 aminomethyltransferase Homo sapiens 90-101
22153537-8 2012 PAI-1 and IL-6 were significantly correlated with mean arterial pressure, BMI, uric acid, total and LDL-cholesterol. Uric Acid 79-88 serpin family E member 1 Homo sapiens 0-5
22286863-8 2012 CONCLUSIONS: Although the mechanism of the relationship between the C677T polymorphism and uric acid still remains unclear, these original articles showed that the MTHFR C677T polymorphism may be an independent risk factor for hyperuricemia. Uric Acid 91-100 methylenetetrahydrofolate reductase Homo sapiens 164-169
21998117-6 2012 RESULTS: The recruitment of the polymorphonuclear cells induced by MSU injection into mouse peritoneal cavity was reduced by 35% with gamma(3)MSH (1 nmol), whereas administration of a much lower dose of purified latent LAP-MMP-gamma(3)MSH (0.03 nmol) attenuated leucocyte influx by 50%. Uric Acid 67-70 proopiomelanocortin Homo sapiens 142-145
21998117-6 2012 RESULTS: The recruitment of the polymorphonuclear cells induced by MSU injection into mouse peritoneal cavity was reduced by 35% with gamma(3)MSH (1 nmol), whereas administration of a much lower dose of purified latent LAP-MMP-gamma(3)MSH (0.03 nmol) attenuated leucocyte influx by 50%. Uric Acid 67-70 transforming growth factor beta 1 Homo sapiens 219-222
21998117-6 2012 RESULTS: The recruitment of the polymorphonuclear cells induced by MSU injection into mouse peritoneal cavity was reduced by 35% with gamma(3)MSH (1 nmol), whereas administration of a much lower dose of purified latent LAP-MMP-gamma(3)MSH (0.03 nmol) attenuated leucocyte influx by 50%. Uric Acid 67-70 proopiomelanocortin Homo sapiens 235-238
22971991-6 2012 Baseline plasma ET-1 levels were significantly associated with age, blood pressure, high-density lipoprotein-cholesterol, renal function, uric acid and all-cause death, but not with cardiovascular or cancer death. Uric Acid 138-147 endothelin 1 Homo sapiens 16-20
23295692-7 2012 With regard to recent findings identifying small particles such as asbestos and monosodium urate as NLRP3 activators, TiO(2) may be another potential target for inflammasome studies. Uric Acid 80-96 NLR family pyrin domain containing 3 Homo sapiens 100-105
22153537-8 2012 PAI-1 and IL-6 were significantly correlated with mean arterial pressure, BMI, uric acid, total and LDL-cholesterol. Uric Acid 79-88 interleukin 6 Homo sapiens 10-14
22020190-3 2012 An amperometric uric acid biosensor was fabricated using uricase/c-MWCNT/PBNPs/Au electrode as working electrode, Ag/AgCl as standard and Pt wire as auxiliary electrode connected through a potentiostat. Uric Acid 16-25 urate oxidase (pseudogene) Homo sapiens 57-64
22101009-8 2012 A simple kinetic model of NO autoxidation is able to explain the extent of cytochrome c oxidation assuming a rate constant of 3x10(6)M(-1)s(-1) for the reaction of NO(2)( ) with ferrocytochrome c. The importance of NO(2)( ) was confirmed by the addition of scavengers such as urate and ferrocyanide. Uric Acid 276-281 cytochrome c, somatic Homo sapiens 75-87
22524012-4 2012 A high affinity of uricase/ZnO to UA was revealed by cyclic voltammograms. Uric Acid 34-36 urate oxidase (pseudogene) Homo sapiens 19-26
22020190-0 2012 Construction of amperometric uric acid biosensor based on uricase immobilized on PBNPs/cMWCNT/PANI/Au composite. Uric Acid 29-38 urate oxidase (pseudogene) Homo sapiens 58-65
22102722-0 2012 P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals. Uric Acid 75-91 pyrimidinergic receptor P2Y6 Homo sapiens 0-13
22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mus musculus 51-57
22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 interleukin 1 alpha Homo sapiens 124-133
22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 C-X-C motif chemokine ligand 8 Homo sapiens 135-139
22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 C-X-C motif chemokine ligand 8 Homo sapiens 140-145
22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 interleukin 6 Homo sapiens 151-155
22102722-6 2012 Similarly, the P2Y(6)-specific antagonist completely inhibited the MSU-induced production of IL-1beta by THP-1 cells, a human monocytic cell line. Uric Acid 67-70 pyrimidinergic receptor P2Y6 Homo sapiens 15-21
22102722-6 2012 Similarly, the P2Y(6)-specific antagonist completely inhibited the MSU-induced production of IL-1beta by THP-1 cells, a human monocytic cell line. Uric Acid 67-70 interleukin 1 beta Homo sapiens 93-101
22449662-6 2012 Serum TRX levels are positively correlated with blood urea nitrogen, serum uric acid and proteinuria, and negatively with estimated glomerular filtration rate (eGFR). Uric Acid 75-84 thioredoxin Homo sapiens 6-9
21822486-5 2012 Adiponectin was inversely correlated with waist circumference and uric acid levels. Uric Acid 66-75 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
21822486-7 2012 In addition to abdominal adiposity, uric acid may be implicated in a decrease of adiponectin in MS patients. Uric Acid 36-45 adiponectin, C1Q and collagen domain containing Homo sapiens 81-92
24331173-8 2012 Adiponectin mRNA was inversely associated with C-peptide (r = -0.416, P < 0.05) and uric acid level (r = -0.426, P < 0.05). Uric Acid 87-96 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
23307163-5 2012 RESULTS: A significant attenuation of the augmented responses to angiotensin II was observed in CoCl(2)-treated animals along with a fall in plasma urea, creatinine and uric acid levels. Uric Acid 169-178 angiotensinogen Rattus norvegicus 65-79
23307286-0 2012 Reducing serum uric acid attenuates TGF-beta1-induced profibrogenic progression in type 2 diabetic nephropathy. Uric Acid 15-24 transforming growth factor, beta 1 Mus musculus 36-45
23307286-3 2012 We examined the hypothesis that lowering serum uric acid attenuates TGF-beta1-induced profibrogenic tubular change in type 2 diabetic nephropathy. Uric Acid 47-56 transforming growth factor, beta 1 Mus musculus 68-77
23307286-9 2012 Uric acid-induced upregulation of TGF-beta1 depends on mitogen-activated protein kinase signaling. Uric Acid 0-9 transforming growth factor, beta 1 Mus musculus 34-43
22579008-11 2012 The decreasing uric acid transport mediated by Bcrp was caused by decrease in the level of Bcrp homodimer, bridged by an S-S bond. Uric Acid 15-24 BCR pseudogene 1 Homo sapiens 47-51
22579008-11 2012 The decreasing uric acid transport mediated by Bcrp was caused by decrease in the level of Bcrp homodimer, bridged by an S-S bond. Uric Acid 15-24 BCR pseudogene 1 Homo sapiens 91-95
22579008-15 2012 The decreasing uric acid flux mediated by Bcrp is caused by suppression of Bcrp S-S bond formation. Uric Acid 15-24 BCR pseudogene 1 Homo sapiens 42-46
22579008-15 2012 The decreasing uric acid flux mediated by Bcrp is caused by suppression of Bcrp S-S bond formation. Uric Acid 15-24 BCR pseudogene 1 Homo sapiens 75-79
22116196-12 2012 Further studies are required to explore the effects of lowering UA on renal protection in IgAN. Uric Acid 64-66 IGAN1 Homo sapiens 90-94
22116260-1 2012 BACKGROUND: Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. Uric Acid 27-36 renin Homo sapiens 108-113
22116260-1 2012 BACKGROUND: Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. Uric Acid 27-36 erythropoietin Homo sapiens 161-175
22116260-1 2012 BACKGROUND: Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. Uric Acid 27-36 erythropoietin Homo sapiens 177-180
22116260-2 2012 We used a dopamine-induced glomerular filtration response test (DIR) to assess whether elevated uric acid is associated with dopamine response and EPO levels in IgA patients. Uric Acid 96-105 erythropoietin Homo sapiens 147-150
22116260-7 2012 RESULTS: Basal EPO was the same in IgA patients and controls (13.5 +- 9.5 vs. 10.6 +- 4.3 mU/ml, respectively; NS); however, EPO correlated with uric acid clearance in IgA patients but not in controls (r = 0.45, p < 0.002 vs. r = 0.25, p < 0.361, respectively), and DIR tended to be lower in IgA nephropathy (p < 0.06). Uric Acid 145-154 erythropoietin Homo sapiens 125-128
22076385-1 2012 OBJECTIVE: The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX). Uric Acid 54-63 CIMT Homo sapiens 128-132
22076385-1 2012 OBJECTIVE: The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX). Uric Acid 54-63 NK2 homeobox 5 Homo sapiens 171-174
22076385-5 2012 RESULTS: Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 +- 1.8 vs. 3.9 +- 1.3 mg/dl; p = 0.002). Uric Acid 15-24 NK2 homeobox 5 Homo sapiens 61-64
22076385-7 2012 A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001). Uric Acid 50-59 CIMT Homo sapiens 71-75
22076385-7 2012 A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001). Uric Acid 50-59 NK2 homeobox 5 Homo sapiens 106-109
22076385-8 2012 CONCLUSIONS: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Uric Acid 19-28 NK2 homeobox 5 Homo sapiens 65-68
22076385-8 2012 CONCLUSIONS: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Uric Acid 19-28 NK2 homeobox 5 Homo sapiens 277-280
22076385-8 2012 CONCLUSIONS: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Uric Acid 88-97 NK2 homeobox 5 Homo sapiens 277-280
22076385-8 2012 CONCLUSIONS: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Uric Acid 88-97 NK2 homeobox 5 Homo sapiens 277-280
23226314-1 2012 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid 14-23 NLR family pyrin domain containing 3 Homo sapiens 199-204
22480418-0 2012 Long-term activation of semicarbazide-sensitive amine oxidase lowers circulating levels of uric acid in diabetic conditions. Uric Acid 91-100 amine oxidase, copper containing 3 Mus musculus 24-61
22480418-13 2012 They also show that uric acid, a multifunctional metabolite at the crossroads of nitrogen waste and of antioxidant defences, can be influenced by SSAO, in a manner apparently related to changes in glucose homeostasis. Uric Acid 20-29 amine oxidase, copper containing 3 Mus musculus 146-150
23284609-7 2012 These data demonstrate that the TLP gene is required for survival of S. Typhimurium in a high uric acid environment such as chicken faeces, and that metabolic traits of Salmonellae in natural and contrived hosts may be fundamentally different. Uric Acid 94-103 TATA box binding protein-like 1 Mus musculus 32-35
21814729-4 2012 However, few studies on urinary calcium and uric acid excretion in children with VUR have been conducted. Uric Acid 44-53 VUR Homo sapiens 81-84
23272134-1 2012 CONTEXT AND OBJECTIVE: Obesity and SLC2A9 genotype are strong determinants of uric acid levels. Uric Acid 78-87 solute carrier family 2 member 9 Homo sapiens 35-41
23272134-3 2012 We examined whether the changes in uric acid levels two- and ten-years after weight loss induced by bariatric surgery were associated with SLC2A9 single nucleotide polymorphisms (SNPs) in the Swedish Obese Subjects study. Uric Acid 35-44 solute carrier family 2 member 9 Homo sapiens 139-145
23272134-8 2012 RESULTS: Overall, 11 of the 14 tested SLC2A9 SNPs were significantly associated with cross-sectional uric acid levels at all three time points, with rs13113918 showing the strongest association at each time point (R(2) = 3.7-5.2%, 3.9x10(-22)<=p<=7.7x10(-11)). Uric Acid 101-110 solute carrier family 2 member 9 Homo sapiens 38-44
23272134-11 2012 CONCLUSIONS: SNPs in the SLC2A9 locus contribute significantly to uric acid levels in obese individuals, and the associations persist even after considerable weight loss due to bariatric surgery. Uric Acid 66-75 solute carrier family 2 member 9 Homo sapiens 25-31
23226314-1 2012 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 199-204
23226314-6 2012 In a mouse model of VILI the effect of allopurinol (inhibits uric acid synthesis) and uricase (degrades uric acid) pre-treatment on neutrophil influx, up-regulation of adhesion molecules, pulmonary and systemic cytokine levels, lung pathology, and regulation of receptors involved in the recognition of uric acid was studied. Uric Acid 104-113 urate oxidase Mus musculus 86-93
23152807-6 2012 Furthermore, we show that a downstream product of AMP metabolism through AMPD2, uric acid, can inhibit AMPK activity in human hepatocytes. Uric Acid 80-89 adenosine monophosphate deaminase 2 Homo sapiens 73-78
23226314-6 2012 In a mouse model of VILI the effect of allopurinol (inhibits uric acid synthesis) and uricase (degrades uric acid) pre-treatment on neutrophil influx, up-regulation of adhesion molecules, pulmonary and systemic cytokine levels, lung pathology, and regulation of receptors involved in the recognition of uric acid was studied. Uric Acid 104-113 urate oxidase Mus musculus 86-93
23152807-6 2012 Furthermore, we show that a downstream product of AMP metabolism through AMPD2, uric acid, can inhibit AMPK activity in human hepatocytes. Uric Acid 80-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 103-107
23166586-4 2012 Since ABCG2 polymorphisms are known to modify essential pharmacokinetic parameters, uric acid metabolism and cancer drug resistance, a direct determination of the erythrocyte membrane ABCG2 protein expression may provide valuable information for assessing these conditions or for devising drug treatments. Uric Acid 84-93 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 6-11
23152807-11 2012 We present the novel finding that uric acid inhibits AMPK kinase activity in fructose-fed hepatocytes thus providing new insights into the pathogenesis of fatty liver. Uric Acid 34-43 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 53-57
23112875-0 2012 Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. Uric Acid 0-9 ketohexokinase Homo sapiens 21-33
23029307-9 2012 CONCLUSION: The data suggest that compared to inflammatory markers such as CRP and IL-6 serum uric acid levels may predict future CVD risk in patients with stable CHD with a risk increase even at levels considered normal. Uric Acid 94-103 interleukin 6 Homo sapiens 83-87
23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Uric Acid 142-151 ketohexokinase Homo sapiens 53-65
23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Uric Acid 142-151 ketohexokinase Homo sapiens 67-70
23112875-4 2012 Here we show in human hepatocytes that uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose. Uric Acid 39-48 ketohexokinase Homo sapiens 62-65
23112875-6 2012 The mechanism whereby uric acid stimulates KHK expression involves the activation of the transcription factor ChREBP, which, in turn, results in the transcriptional activation of KHK by binding to a specific sequence within its promoter. Uric Acid 22-31 ketohexokinase Homo sapiens 43-46
23112875-6 2012 The mechanism whereby uric acid stimulates KHK expression involves the activation of the transcription factor ChREBP, which, in turn, results in the transcriptional activation of KHK by binding to a specific sequence within its promoter. Uric Acid 22-31 MLX interacting protein like Homo sapiens 110-116
23112875-6 2012 The mechanism whereby uric acid stimulates KHK expression involves the activation of the transcription factor ChREBP, which, in turn, results in the transcriptional activation of KHK by binding to a specific sequence within its promoter. Uric Acid 22-31 ketohexokinase Homo sapiens 179-182
22768267-0 2012 Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects. Uric Acid 6-15 serum amyloid A1 Homo sapiens 63-67
23024809-9 2012 XDH mutations in man cause xanthinuria with undetectable plasma uric acid levels and three RENF mice had plasma uric acid levels below the limit of detection. Uric Acid 64-73 xanthine dehydrogenase Homo sapiens 0-3
22761883-6 2012 In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-alpha, MCP-1 and RANTES mRNA as well as RANTES protein expression. Uric Acid 48-57 tumor necrosis factor Mus musculus 111-120
22761883-6 2012 In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-alpha, MCP-1 and RANTES mRNA as well as RANTES protein expression. Uric Acid 48-57 mast cell protease 1 Mus musculus 122-127
22761883-6 2012 In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-alpha, MCP-1 and RANTES mRNA as well as RANTES protein expression. Uric Acid 48-57 chemokine (C-C motif) ligand 5 Mus musculus 132-138
22761883-6 2012 In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-alpha, MCP-1 and RANTES mRNA as well as RANTES protein expression. Uric Acid 48-57 chemokine (C-C motif) ligand 5 Mus musculus 155-161
22761883-9 2012 The uric acid-induced up-regulation of RANTES was blocked by SN 50, a specific NF-kappaB inhibitor. Uric Acid 4-13 chemokine (C-C motif) ligand 5 Mus musculus 39-45
22606360-7 2012 Transgenic UOx expression decreased endogenous urate content both in neurons and astrocytes. Uric Acid 47-52 urate oxidase Mus musculus 11-14
22629362-4 2012 Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. Uric Acid 124-133 haptoglobin Homo sapiens 12-19
22701621-3 2012 Urate and lipid are considered as danger signals in the NLRP3 inflammasome activation. Uric Acid 0-5 NLR family, pyrin domain containing 3 Rattus norvegicus 56-61
22393348-2 2012 To date, several recent genome-wide association studies (GWAS) and follow-up studies have identified genetic variants of SLC2A9 associated with urate concentrations and susceptibility to gout. Uric Acid 144-149 solute carrier family 2 member 9 Homo sapiens 121-127
22348008-0 2012 Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. Uric Acid 27-36 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 71-75
22348008-0 2012 Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. Uric Acid 27-36 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 76-81
22348008-8 2012 Bcrp1 knockout mice exhibited significantly decreased intestinal secretion and an increased plasma concentration of uric acid. Uric Acid 116-125 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-5
22348008-9 2012 Furthermore, a Bcrp inhibitor, elacridar, caused a decrease of intestinal secretion of uric acid. Uric Acid 87-96 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 15-19
22348008-11 2012 These results demonstrate that BCRP contributes at least in part to the intestinal excretion of uric acid as extra-renal elimination pathway in humans and rats. Uric Acid 96-105 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 31-35
23461168-4 2012 On the other hand, some of the data not related to the action of the components used in carrier solution, demonstrated dose-dependent variation: found increased activity on 21-35% in the CYP2B1 at doses of 1 mg/kg and 10 mg/kg body weight, and reduced concentration of uric acid and increasing concentrations of urea at 10 mg/kg body weight. Uric Acid 269-278 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 187-193
22320145-8 2012 On stepwise multiple regression analysis, increased CRP (>=12 mg/L), uric acid (>=5 mg/L), and RRI (>=0.70) were independent variables for increased cTnT status (r(2) = 0.053, p < 0.05). Uric Acid 72-81 troponin T2, cardiac type Homo sapiens 158-162
23013150-6 2012 Furthermore, insulin resistance is thought to alter renal acid-base metabolism, resulting in a lower urine pH and increased risk of uric acid stone disease. Uric Acid 132-141 insulin Homo sapiens 13-20
22260409-7 2012 The main pathophysiological mechanisms of these deleterious effects caused by uric acid are endothelial dysfunction, activation of local renin-angiotensin system, increased oxidative stress, and proinflammatory and proliferative actions. Uric Acid 78-87 renin Homo sapiens 137-142
22448318-1 2012 Febuxostat, a drug recently approved in the US, European Union and Japan for treatment of gout, inhibits xanthine oxidoreductase (XOR)-mediated generation of uric acid during purine catabolism. Uric Acid 158-167 xanthine dehydrogenase Homo sapiens 105-128
22448318-1 2012 Febuxostat, a drug recently approved in the US, European Union and Japan for treatment of gout, inhibits xanthine oxidoreductase (XOR)-mediated generation of uric acid during purine catabolism. Uric Acid 158-167 xanthine dehydrogenase Homo sapiens 130-133
22736977-0 2012 A potentiometric indirect uric acid sensor based on ZnO nanoflakes and immobilized uricase. Uric Acid 26-35 urate oxidase (pseudogene) Homo sapiens 83-90
22736977-2 2012 The enzyme uricase was electrostatically immobilized in conjunction with Nafion membrane on the surface of well oriented ZnO-NFs, resulting in a sensitive, selective, stable and reproducible uric acid sensor. Uric Acid 191-200 urate oxidase (pseudogene) Homo sapiens 11-18
22774474-11 2012 Trp64Arg genotypes of ADRB3 compared to Trp64Trp genotypes had significantly higher body fat percentage (respectively 48,6 +/- 0,96% and 43,8 +/- 1,72%, p<0,05), serum glucose (6,51 +/- 0,18 mmol/l and 5,67 +/- 0,09 mmol/l, p<0,01) and uric acid concentrations (0,46 +/- 0,02 mmol/l and 0,38 +/- 0,01 mmol/l, p<0,05). Uric Acid 242-251 adrenoceptor beta 3 Homo sapiens 22-27
21360059-0 2011 Valproic acid modulates superoxide dismutase, uric acid-independent FRAP and zinc in blood of adult epileptic patients. Uric Acid 46-55 mechanistic target of rapamycin kinase Homo sapiens 68-72
21623992-6 2011 CONCLUSIONS: Elevated serum uric acid levels are correlated with higher O(2)(-) and TNF-alpha production by monocytes in women with PE. Uric Acid 28-37 tumor necrosis factor Homo sapiens 84-93
22219597-16 2011 HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations. Uric Acid 14-23 BCL2 apoptosis regulator Homo sapiens 64-69
21996325-3 2011 The prepared bioelectrode (uricase/NiO/Pt/Ti/glass) is utilized for sensing uric acid using the cyclic voltammetry and UV visible spectroscopy techniques. Uric Acid 76-85 urate oxidase (pseudogene) Homo sapiens 27-34
21604970-7 2011 Because HMGB1 is activated through binding to interleukin 1beta, and that this cytokine is produced by the NLRP3 inflammasome that could be stimulated by uric acid, we propose that both alarmins could be acting in concert with the induction of the autoAb to FAH in MHV-infected mice. Uric Acid 154-163 high mobility group box 1 Mus musculus 8-13
21822924-0 2011 Lymphocyte alpha-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses. Uric Acid 63-91 alpha kinase 1 Homo sapiens 0-23
21175590-7 2011 In addition to its role in cancer, ABCG2 also plays a role in the normal physiological transport of urate and haem, the implications of which are described. Uric Acid 100-105 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 35-40
22034506-6 2011 With respect to biochemical parameters, higher parathyroid hormone, phosphate, uric acid, and triglyceride levels all were associated independently with higher FGF23 in models adjusted for age, creatinine, and other factors. Uric Acid 79-88 fibroblast growth factor 23 Homo sapiens 160-165
22058415-0 2011 Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. Uric Acid 0-9 interleukin 1 alpha Homo sapiens 68-72
22058415-0 2011 Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. Uric Acid 0-9 interleukin 18 Homo sapiens 77-82
22058415-4 2011 Accordingly, naive CD4(+) T cells cocultured with uric acid-treated dendritic cells differentiated toward the Th17 lineage. Uric Acid 50-59 CD4 molecule Homo sapiens 19-22
22013014-8 2011 Elevation of the Gck-to-Gckr ratio in hepatocytes was associated with glucose-dependent ATP depletion and elevated urate production confirming compromised phosphate homeostasis. Uric Acid 115-120 glucokinase Mus musculus 17-20
22013014-8 2011 Elevation of the Gck-to-Gckr ratio in hepatocytes was associated with glucose-dependent ATP depletion and elevated urate production confirming compromised phosphate homeostasis. Uric Acid 115-120 glucokinase regulatory protein Mus musculus 24-28
22132962-0 2011 ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans. Uric Acid 86-95 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
22132990-0 2011 Increased expression of SLC2A9 decreases urate excretion from the kidney. Uric Acid 41-46 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 24-30
22132990-4 2011 URAT1 and URATv1 are vital to renal urate reabsorption because the experimental data have illustrated that functional loss of these transporter proteins affords hypouricemia. Uric Acid 36-41 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 0-5
22132990-7 2011 Plasma urate concentrations in URAT1 and URATv1 Tg mice were not significantly different from that in wild-type (WT) mice. Uric Acid 7-12 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 31-36
22359474-0 2011 Inhibition of Inducible Nitric Oxide Synthase Attenuates Monosodium Urate-induced Inflammation in Mice. Uric Acid 57-73 nitric oxide synthase 2, inducible Mus musculus 14-45
22359474-1 2011 The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. Uric Acid 146-162 nitric oxide synthase 2, inducible Mus musculus 57-88
22359474-1 2011 The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. Uric Acid 146-162 nitric oxide synthase 2, inducible Mus musculus 90-94
22359474-1 2011 The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. Uric Acid 164-167 nitric oxide synthase 2, inducible Mus musculus 57-88
22359474-1 2011 The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. Uric Acid 164-167 nitric oxide synthase 2, inducible Mus musculus 90-94
22132964-10 2011 These findings also enable us to propose a physiological model of the renal urate reabsorption via GLUT9 and URAT1 and can lead to a promising therapeutic target for gout and related cardiovascular diseases. Uric Acid 76-81 solute carrier family 22 member 12 Homo sapiens 109-114
22132965-13 2011 Our finding of the defects in SLC22A12 and SLC2A9 genes gives further evidence of the causative genes of primary renal hypouricemia and supports their important role in regulation of serum urate levels in humans. Uric Acid 189-194 solute carrier family 22 member 12 Homo sapiens 30-38
22132965-13 2011 Our finding of the defects in SLC22A12 and SLC2A9 genes gives further evidence of the causative genes of primary renal hypouricemia and supports their important role in regulation of serum urate levels in humans. Uric Acid 189-194 solute carrier family 2 member 9 Homo sapiens 43-49
22132966-1 2011 Recent genome-wide association studies showed that serum uric acid (SUA) levels relate to ABCG2/BCRP gene, which locates in a gout-susceptibility locus revealed by a genome-wide linkage study. Uric Acid 57-66 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 90-95
22132991-5 2011 We previously identified that renal urate absorption in proximal tubular epithelial cells occurs mainly via apical urate/anion exchanger, URAT1/SLC22A12, and by facilitated diffusion along the trans-membrane potential gradient by the basolateral voltage-driven urate efflux transporter, URATv1/SLC2A9/GLUT9. Uric Acid 36-41 solute carrier family 22 member 12 Homo sapiens 138-143
22132991-5 2011 We previously identified that renal urate absorption in proximal tubular epithelial cells occurs mainly via apical urate/anion exchanger, URAT1/SLC22A12, and by facilitated diffusion along the trans-membrane potential gradient by the basolateral voltage-driven urate efflux transporter, URATv1/SLC2A9/GLUT9. Uric Acid 36-41 solute carrier family 22 member 12 Homo sapiens 144-152
22132991-5 2011 We previously identified that renal urate absorption in proximal tubular epithelial cells occurs mainly via apical urate/anion exchanger, URAT1/SLC22A12, and by facilitated diffusion along the trans-membrane potential gradient by the basolateral voltage-driven urate efflux transporter, URATv1/SLC2A9/GLUT9. Uric Acid 36-41 solute carrier family 2 member 9 Homo sapiens 287-293
22132991-5 2011 We previously identified that renal urate absorption in proximal tubular epithelial cells occurs mainly via apical urate/anion exchanger, URAT1/SLC22A12, and by facilitated diffusion along the trans-membrane potential gradient by the basolateral voltage-driven urate efflux transporter, URATv1/SLC2A9/GLUT9. Uric Acid 36-41 solute carrier family 2 member 9 Homo sapiens 294-300
22132991-5 2011 We previously identified that renal urate absorption in proximal tubular epithelial cells occurs mainly via apical urate/anion exchanger, URAT1/SLC22A12, and by facilitated diffusion along the trans-membrane potential gradient by the basolateral voltage-driven urate efflux transporter, URATv1/SLC2A9/GLUT9. Uric Acid 36-41 solute carrier family 2 member 9 Homo sapiens 301-306
22132962-2 2011 ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Uric Acid 171-180 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 0-5
22132991-9 2011 An in vivo role of hNPT4 is supported by the fact that missense mutations in SLC17A3 present in hyperuricemia patients with urate underexcretion abolished urate efflux capacity in vitro. Uric Acid 124-129 solute carrier family 17 member 3 Homo sapiens 19-24
22132991-9 2011 An in vivo role of hNPT4 is supported by the fact that missense mutations in SLC17A3 present in hyperuricemia patients with urate underexcretion abolished urate efflux capacity in vitro. Uric Acid 124-129 solute carrier family 17 member 3 Homo sapiens 77-84
22132966-1 2011 Recent genome-wide association studies showed that serum uric acid (SUA) levels relate to ABCG2/BCRP gene, which locates in a gout-susceptibility locus revealed by a genome-wide linkage study. Uric Acid 57-66 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 96-100
22132992-3 2011 An anion appears to be a primary requirement in order to be a hURAT1 substrate (i.e., urate) or inhibitor. Uric Acid 86-91 solute carrier family 22 member 12 Homo sapiens 62-68
22132962-3 2011 Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. Uric Acid 8-13 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 82-87
22132966-2 2011 Together with the ABCG2 characteristics, we hypothesized that ABCG2 transports urate and its dysfunction causes hyperuricemia and gout. Uric Acid 79-84 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 18-23
22132962-3 2011 Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. Uric Acid 99-104 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 82-87
22132966-2 2011 Together with the ABCG2 characteristics, we hypothesized that ABCG2 transports urate and its dysfunction causes hyperuricemia and gout. Uric Acid 79-84 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 62-67
22132962-5 2011 Transport of estrone-3-sulfate (ES), a typical substrate of ABCG2, is inhibited by urate as well as AZT and ES. Uric Acid 83-88 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 60-65
22132966-3 2011 Transport assays showed ATP-dependent transport of urate via ABCG2. Uric Acid 51-56 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 61-66
22132966-4 2011 Kinetic analysis revealed that ABCG2 mediates high-capacity transport of urate (Km: 8.24 +- 1.44 mM) even under high-urate conditions. Uric Acid 73-78 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 31-36
22132962-6 2011 ATP-dependent transport of urate was then detected in ABCG2-expressing vesicles but not in control vesicles. Uric Acid 27-32 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 54-59
22132966-4 2011 Kinetic analysis revealed that ABCG2 mediates high-capacity transport of urate (Km: 8.24 +- 1.44 mM) even under high-urate conditions. Uric Acid 117-122 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 31-36
22132962-7 2011 Kinetic analysis revealed that ABCG2 is a high-capacity urate transporter that maintained its function even under high-urate concentration. Uric Acid 56-61 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 31-36
22132962-8 2011 The calculated parameters of ABCG2-mediated transport of urate were a Km of 8.24 +- 1.44 mM and a Vmax of 6.96 +- 0.89 nmol/min per mg of protein. Uric Acid 57-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 29-34
22132963-2 2011 Recent genome-wide association studies also showed that the ABCG2 gene relates to serum uric acid levels and gout. Uric Acid 88-97 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 60-65
22132963-3 2011 Since ABCG2 is also known as a transporter of nucleotide analogs that are structurally similar to urate, and is an exporter that has common polymorphic reduced functionality variants, ABCG2 could be a urate secretion transporter and a gene causing gout. Uric Acid 98-103 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 6-11
22132963-3 2011 Since ABCG2 is also known as a transporter of nucleotide analogs that are structurally similar to urate, and is an exporter that has common polymorphic reduced functionality variants, ABCG2 could be a urate secretion transporter and a gene causing gout. Uric Acid 98-103 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 184-189
22132964-2 2011 We have previously reported that URAT1/SLC22A12 encodes a renal urate-anion exchanger and that its mutations cause renal hypouricemia type 1 (RHUC1). Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 33-38
22132964-2 2011 We have previously reported that URAT1/SLC22A12 encodes a renal urate-anion exchanger and that its mutations cause renal hypouricemia type 1 (RHUC1). Uric Acid 64-69 solute carrier family 22 member 12 Homo sapiens 39-47
22132964-7 2011 GLUT9 mutants showed markedly reduced urate transport in oocyte expression studies, which would be the result of the loss of positive charges in those conserved amino acid motifs. Uric Acid 38-43 solute carrier family 2 member 9 Homo sapiens 0-5
22132964-8 2011 Together with previous reports on GLUT9 localization, our findings suggest that these GLUT9 mutations cause renal hypouricemia type 2 (RHUC2) by their decreased urate reabsorption on both sides of the renal proximal tubule cells. Uric Acid 161-166 solute carrier family 2 member 9 Homo sapiens 34-39
22132964-8 2011 Together with previous reports on GLUT9 localization, our findings suggest that these GLUT9 mutations cause renal hypouricemia type 2 (RHUC2) by their decreased urate reabsorption on both sides of the renal proximal tubule cells. Uric Acid 161-166 solute carrier family 2 member 9 Homo sapiens 86-91
22132964-10 2011 These findings also enable us to propose a physiological model of the renal urate reabsorption via GLUT9 and URAT1 and can lead to a promising therapeutic target for gout and related cardiovascular diseases. Uric Acid 76-81 solute carrier family 2 member 9 Homo sapiens 99-104
22187784-4 2011 Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. Uric Acid 108-117 solute carrier family 2 member 9 Homo sapiens 140-146
22167616-1 2011 Xanthinuria is a rare autosomal recessive disorder associated with a deficiency of xanthine oxidoreductase (XOR), which normally catalyzes the conversion of hypoxanthine to uric acid. Uric Acid 173-182 xanthine dehydrogenase Homo sapiens 108-111
21946433-4 2011 Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P<0.05). Uric Acid 0-16 interleukin 6 Homo sapiens 103-107
21946433-4 2011 Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P<0.05). Uric Acid 0-16 C-X-C motif chemokine ligand 8 Homo sapiens 123-128
21946433-4 2011 Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P<0.05). Uric Acid 0-16 matrix metallopeptidase 1 Homo sapiens 137-169
21946433-5 2011 Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta. Uric Acid 164-180 interleukin 6 Homo sapiens 63-67
21946433-5 2011 Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta. Uric Acid 164-180 C-X-C motif chemokine ligand 8 Homo sapiens 69-74
21946433-5 2011 Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta. Uric Acid 164-180 matrix metallopeptidase 1 Homo sapiens 79-84
21946433-6 2011 Further experiments showed that the release of the measured inflammatory cytokine, chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway. Uric Acid 117-133 matrix metallopeptidase 1 Homo sapiens 97-102
21946433-6 2011 Further experiments showed that the release of the measured inflammatory cytokine, chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway. Uric Acid 117-133 mitogen-activated protein kinase 14 Homo sapiens 295-298
21983786-3 2011 We identified a low-frequency missense variant (c.1580C>G) in ALDH16A1 associated with gout (OR = 3.12, P = 1.5 x 10(-16), at-risk allele frequency = 0.019) and serum uric acid levels (effect = 0.36 s.d., P = 4.5 x 10(-21)). Uric Acid 170-179 aldehyde dehydrogenase 16 family member A1 Homo sapiens 65-73
21768215-0 2011 Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. Uric Acid 40-45 solute carrier family 22 member 12 Homo sapiens 135-140
21768215-6 2011 In the discovery GWAS of serum urate, three loci achieved genome-wide significance (P< 5.0 x 10(-8)): a novel locus near SGK1/SLC2A12 on chromosome 6 (rs9321453, P= 1.0 x 10(-9)), and two loci previously identified in EA participants, SLC2A9 (P= 3.8 x 10(-32)) and SLC22A12 (P= 2.1 x 10(-10)). Uric Acid 31-36 serum/glucocorticoid regulated kinase 1 Homo sapiens 124-128
21768215-6 2011 In the discovery GWAS of serum urate, three loci achieved genome-wide significance (P< 5.0 x 10(-8)): a novel locus near SGK1/SLC2A12 on chromosome 6 (rs9321453, P= 1.0 x 10(-9)), and two loci previously identified in EA participants, SLC2A9 (P= 3.8 x 10(-32)) and SLC22A12 (P= 2.1 x 10(-10)). Uric Acid 31-36 solute carrier family 2 member 12 Homo sapiens 129-136
21768215-6 2011 In the discovery GWAS of serum urate, three loci achieved genome-wide significance (P< 5.0 x 10(-8)): a novel locus near SGK1/SLC2A12 on chromosome 6 (rs9321453, P= 1.0 x 10(-9)), and two loci previously identified in EA participants, SLC2A9 (P= 3.8 x 10(-32)) and SLC22A12 (P= 2.1 x 10(-10)). Uric Acid 31-36 solute carrier family 2 member 9 Homo sapiens 238-244
21768215-6 2011 In the discovery GWAS of serum urate, three loci achieved genome-wide significance (P< 5.0 x 10(-8)): a novel locus near SGK1/SLC2A12 on chromosome 6 (rs9321453, P= 1.0 x 10(-9)), and two loci previously identified in EA participants, SLC2A9 (P= 3.8 x 10(-32)) and SLC22A12 (P= 2.1 x 10(-10)). Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 268-276
21768215-8 2011 (14)C-urate transport assays showed reduced urate transport for the G65W URAT1 mutant. Uric Acid 6-11 solute carrier family 22 member 12 Homo sapiens 73-78
21768215-8 2011 (14)C-urate transport assays showed reduced urate transport for the G65W URAT1 mutant. Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 73-78
22002608-6 2011 Interestingly, Casp11(-/-) macrophages secreted IL-1beta normally in response to ATP and monosodium urate, indicating that caspase-11 is engaged by a non-canonical inflammasome. Uric Acid 89-105 caspase 4, apoptosis-related cysteine peptidase Mus musculus 15-21
22002608-6 2011 Interestingly, Casp11(-/-) macrophages secreted IL-1beta normally in response to ATP and monosodium urate, indicating that caspase-11 is engaged by a non-canonical inflammasome. Uric Acid 89-105 interleukin 1 beta Mus musculus 48-56
22036135-10 2011 Using uric acid >= 5.0 mg/dL as a cutoff point, we could diagnose insulin resistance with 75.4% sensitivity and 73.1% specificity. Uric Acid 6-15 insulin Homo sapiens 69-76
22036135-13 2011 Among these, high serum uric acid levels seemed to be a useful marker identifying postmenopausal women with insulin resistance. Uric Acid 24-33 insulin Homo sapiens 108-115
21459390-6 2011 An optimized IRS index was defined by triglycerides of at least 1.6 mmol/L and uric acid of at least 400 mumol/L plus any one of fasting plasma glucose of at least 5.4 mmol/L, diastolic blood pressure of at least 90 mm Hg, or body mass index of at least 27.0 kg/m(2) and predicted CVD mortality (hazard ratio, 2.14 [1.08-4.24]; P = .02). Uric Acid 79-88 isoleucyl-tRNA synthetase 1 Homo sapiens 13-16
21331772-1 2011 Lesch-Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. Uric Acid 256-265 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 108-154
21959625-3 2011 Xanthine oxidoreductase (XOR) has been previously characterized as a housekeeping enzyme responsible for cellular uric acid formation via enzymatic conversion of hypoxanthine and xanthine. Uric Acid 114-123 xanthine dehydrogenase Homo sapiens 0-23
21959625-3 2011 Xanthine oxidoreductase (XOR) has been previously characterized as a housekeeping enzyme responsible for cellular uric acid formation via enzymatic conversion of hypoxanthine and xanthine. Uric Acid 114-123 xanthine dehydrogenase Homo sapiens 25-28
21331772-1 2011 Lesch-Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. Uric Acid 256-265 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 156-160
21936977-2 2011 Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ss-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. Uric Acid 70-75 NLR family pyrin domain containing 3 Homo sapiens 203-209
21046132-5 2011 RESULTS: Serum CA-125 concentrations were found to correlate positively with systolic blood pressure (r = 0.345, p = 0.001), diastolic blood pressure (r = 0.379, p = 0.001), platelet count (r = 0.368, p = 0.001), serum levels of uric acid (r = 0.415, p = 0.001) and urine concentrations of protein (r = 0.357, p = 0.001). Uric Acid 229-238 mucin 16, cell surface associated Homo sapiens 15-21
21774633-1 2011 Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. Uric Acid 169-178 xanthine dehydrogenase Homo sapiens 0-23
21521327-7 2011 RESULTS: In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0 001). Uric Acid 253-262 gamma-glutamyltransferase light chain family member 3 Homo sapiens 71-74
21554546-6 2011 We focus on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2. Uric Acid 126-131 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 49-54
21554546-6 2011 We focus on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2. Uric Acid 126-131 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 165-170
21929350-4 2011 Uric acid remained an independent determinant of serum GGT activity on admission. Uric Acid 0-9 gamma-glutamyltransferase 1 Homo sapiens 55-58
21774633-1 2011 Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. Uric Acid 169-178 xanthine dehydrogenase Homo sapiens 25-28
21774633-3 2011 The ability of XOR to perform detoxification reactions, and to synthesize UA and reactive oxygen species (ROS) makes it a versatile intra- and extra-cellular protective "housekeeping enzyme". Uric Acid 74-76 xanthine dehydrogenase Homo sapiens 15-18
21752574-5 2011 Genetic studies have found that variants of GLUT9 and ABCG2 were associated with urate levels. Uric Acid 81-86 solute carrier family 2 member 9 Homo sapiens 44-49
20962858-0 2011 The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. Uric Acid 28-37 adiponectin, C1Q and collagen domain containing Homo sapiens 67-78
21573893-6 2011 Besides ATP, uric acid or soluble extracellular matrix components are functional danger signals that activate the NLRP3 inflammasome when released from dying cells or from extracellular matrix. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 114-119
21752574-5 2011 Genetic studies have found that variants of GLUT9 and ABCG2 were associated with urate levels. Uric Acid 81-86 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 54-59
21684106-3 2011 In case of uric acid lithiasis, you must search a metabolic syndrome, an insulin resistance, a type 2 diabetes. Uric Acid 11-20 insulin Homo sapiens 73-80
21757641-5 2011 Febuxostat, a nonpurine inhibitor of xanthine oxidase (also known as xanthine dehydrogenase or xanthine oxidoreductase) may have advantages over allopurinol and is being tested in a similar protocol, with the eventual goal of determining whether urate-lowering therapy prevents recurrent calcium stones. Uric Acid 246-251 xanthine dehydrogenase Homo sapiens 69-91
22000645-2 2011 The consequence of being a uricase knockout is that we have higher serum uric acid levels that are less regulatable and can be readily influenced by diet. Uric Acid 73-82 urate oxidase (pseudogene) Homo sapiens 27-34
22000646-1 2011 Urate (uric acid) is the end product of purine metabolism in human beings owing to the genetic loss of hepatic urate oxidase (uricase). Uric Acid 0-5 urate oxidase (pseudogene) Homo sapiens 126-133
22000646-1 2011 Urate (uric acid) is the end product of purine metabolism in human beings owing to the genetic loss of hepatic urate oxidase (uricase). Uric Acid 7-16 urate oxidase (pseudogene) Homo sapiens 126-133
22000646-4 2011 Although molecular identification of the urate/anion exchanger URAT1 (SLC22A12) in 2002 paved the way for successive identification of several urate transport-related proteins, the entire picture of effective renal urate handling in human beings has not yet been clarified. Uric Acid 41-46 solute carrier family 22 member 12 Homo sapiens 63-68
22000646-4 2011 Although molecular identification of the urate/anion exchanger URAT1 (SLC22A12) in 2002 paved the way for successive identification of several urate transport-related proteins, the entire picture of effective renal urate handling in human beings has not yet been clarified. Uric Acid 41-46 solute carrier family 22 member 12 Homo sapiens 70-78
22000648-2 2011 Knowledge of genetic control of serum urate in other populations can be extrapolated from the study of gout, a condition of extreme hyperuricemia; three urate transport genes (SLC2A9, ABCG2, and SLC17A1/NPT1) have been studied in diverse populations (Caucasian, Asian, and Polynesian). Uric Acid 38-43 solute carrier family 2 member 9 Homo sapiens 176-182
21816063-5 2011 RESULTS: Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). Uric Acid 9-18 epidermal growth factor receptor Homo sapiens 121-125
21816063-5 2011 RESULTS: Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). Uric Acid 9-18 C-reactive protein Homo sapiens 187-190
21816063-5 2011 RESULTS: Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). Uric Acid 9-18 acrosin Homo sapiens 253-256
22000648-2 2011 Knowledge of genetic control of serum urate in other populations can be extrapolated from the study of gout, a condition of extreme hyperuricemia; three urate transport genes (SLC2A9, ABCG2, and SLC17A1/NPT1) have been studied in diverse populations (Caucasian, Asian, and Polynesian). Uric Acid 38-43 solute carrier family 17 member 1 Homo sapiens 195-202
22000648-2 2011 Knowledge of genetic control of serum urate in other populations can be extrapolated from the study of gout, a condition of extreme hyperuricemia; three urate transport genes (SLC2A9, ABCG2, and SLC17A1/NPT1) have been studied in diverse populations (Caucasian, Asian, and Polynesian). Uric Acid 38-43 solute carrier family 17 member 1 Homo sapiens 203-207
22000648-2 2011 Knowledge of genetic control of serum urate in other populations can be extrapolated from the study of gout, a condition of extreme hyperuricemia; three urate transport genes (SLC2A9, ABCG2, and SLC17A1/NPT1) have been studied in diverse populations (Caucasian, Asian, and Polynesian). Uric Acid 153-158 solute carrier family 2 member 9 Homo sapiens 176-182
22000651-3 2011 Animal models have suggested a two-step pathogenesis by which uric acid initially activates the renin angiotensin system and suppresses nitric oxide, leading to uric acid-dependent increase in systemic vascular resistance, followed by a uric acid-mediated vasculopathy, involving renal afferent arterioles, resulting in a late sodium-sensitive hypertension. Uric Acid 62-71 renin Homo sapiens 96-101
21415844-5 2011 CONCLUSION: These results suggest that ROS directly injures the placental syncytiotrophoblast in PIH patients and that elevated UA in PIH patients, at least partly, indicates placental damage induced by ROS. Uric Acid 128-130 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 134-137
20861868-5 2011 These findings add evidence concerning an age-modulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly. Uric Acid 91-100 fibrinogen beta chain Homo sapiens 105-115
21511506-0 2011 Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population. Uric Acid 33-42 solute carrier family 2 member 9 Homo sapiens 55-61
21511506-1 2011 Genome-wide association studies identified that SLC2A9 (GLUT9) gene polymorphisms were associated with serum uric acid (SUA) levels. Uric Acid 109-118 solute carrier family 2 member 9 Homo sapiens 48-54
21511506-1 2011 Genome-wide association studies identified that SLC2A9 (GLUT9) gene polymorphisms were associated with serum uric acid (SUA) levels. Uric Acid 109-118 solute carrier family 2 member 9 Homo sapiens 56-61
21665458-6 2011 In addition, the Pt/CNF electrode showed good selectivity for H2O2 detection in the presence of ascorbic acid (AA), acetaminophenol (AP) and uric acid (UA) under physiological pH condition. Uric Acid 141-150 NPHS1 adhesion molecule, nephrin Homo sapiens 20-23
21665458-6 2011 In addition, the Pt/CNF electrode showed good selectivity for H2O2 detection in the presence of ascorbic acid (AA), acetaminophenol (AP) and uric acid (UA) under physiological pH condition. Uric Acid 152-154 NPHS1 adhesion molecule, nephrin Homo sapiens 20-23
21550723-0 2011 Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats. Uric Acid 50-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 8-13
21540182-6 2011 Among various oxypurines tested, only IBMX, xanthine, or uric acid significantly increased the apparent K(m) for glutamate and decreased velocity of NAGS, with little effect on CPS1. Uric Acid 57-66 N-acetylglutamate synthase Mus musculus 149-153
21542015-5 2011 Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (beta = -2.687, P = .011). Uric Acid 59-68 ATPase H+ transporting V0 subunit a2 Homo sapiens 186-195
20227256-9 2011 CD34(+)/CD133(+)/KDR(+) count inversely correlated with uric acid (-0.28;<0.005) and FPI (-0.2;<0.05). Uric Acid 56-65 CD34 molecule Homo sapiens 0-4
20227256-9 2011 CD34(+)/CD133(+)/KDR(+) count inversely correlated with uric acid (-0.28;<0.005) and FPI (-0.2;<0.05). Uric Acid 56-65 prominin 1 Homo sapiens 8-13
20227256-9 2011 CD34(+)/CD133(+)/KDR(+) count inversely correlated with uric acid (-0.28;<0.005) and FPI (-0.2;<0.05). Uric Acid 56-65 kinase insert domain receptor Homo sapiens 17-20
21088472-0 2011 Serum uric acid in relation with the metabolic syndrome components and adiponectin levels in Lebanese University students. Uric Acid 6-15 adiponectin, C1Q and collagen domain containing Homo sapiens 71-82
21540182-6 2011 Among various oxypurines tested, only IBMX, xanthine, or uric acid significantly increased the apparent K(m) for glutamate and decreased velocity of NAGS, with little effect on CPS1. Uric Acid 57-66 carbamoyl-phosphate synthetase 1 Mus musculus 177-181
21430503-4 2011 This presentation adds to the advantages of an NPB: the detection of some cases of gout on which urate crystals are extruded subclinically. Uric Acid 97-102 neuropeptide B Homo sapiens 47-50
21480532-1 2011 Nonpurine xanthine oxidoreductase (XOR) inhibitors represent important alternatives to the purine analogue allopurinol, which is still the most widely used drug in the treatment of conditions associated with elevated uric acid levels in the blood. Uric Acid 217-226 xanthine dehydrogenase Homo sapiens 10-33
21480532-1 2011 Nonpurine xanthine oxidoreductase (XOR) inhibitors represent important alternatives to the purine analogue allopurinol, which is still the most widely used drug in the treatment of conditions associated with elevated uric acid levels in the blood. Uric Acid 217-226 xanthine dehydrogenase Homo sapiens 35-38
21315682-1 2011 An amperometric uric acid biosensor was fabricated by immobilizing uricase (EC 1.7.3.3) onto gold nanoparticle (AuNP)/multiwalled carbon nanotube (MWCNT) layer deposited on Au electrode via carbodiimide linkage. Uric Acid 16-25 urate oxidase (pseudogene) Homo sapiens 67-74
21441208-6 2011 A screen of these deletion mutants revealed GAT1, encoding the only global transcription factor essential for utilization of a wide range of nitrogen sources, including uric acid, urea, and creatinine-three predominant nitrogen constituents found in the C. neoformans ecological niche. Uric Acid 169-178 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Mus musculus 44-48
21352397-0 2011 Uric acid induces trophoblast IL-1beta production via the inflammasome: implications for the pathogenesis of preeclampsia. Uric Acid 0-9 interleukin 1 beta Homo sapiens 30-38
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 71-76
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 0-9 interleukin 1 beta Homo sapiens 117-125
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 14-30 NLR family pyrin domain containing 3 Homo sapiens 71-76
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 14-30 interleukin 1 beta Homo sapiens 117-125
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 32-35 NLR family pyrin domain containing 3 Homo sapiens 71-76
21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 32-35 interleukin 1 beta Homo sapiens 117-125
21352397-11 2011 CONCLUSION: These findings demonstrate that uric acid activates the inflammasome in the trophoblast, leading to IL-1beta production. Uric Acid 44-53 interleukin 1 beta Homo sapiens 112-120
21074513-1 2011 Uric acid transporter URAT1 contributes significantly to reabsorption of uric acid in humans to maintain a constant serum uric acid (SUA) level. Uric Acid 73-82 solute carrier family 22 member 12 Homo sapiens 22-27
21074513-1 2011 Uric acid transporter URAT1 contributes significantly to reabsorption of uric acid in humans to maintain a constant serum uric acid (SUA) level. Uric Acid 122-131 solute carrier family 22 member 12 Homo sapiens 22-27
20878500-5 2011 At linear regression analyses, GGT was significantly correlated with admission glycemia (r = 0.172; p = 0.002), uric acid (r = 0.146; p = 0.011), insulin (r = 0.171; p = 0.002) and age (r = -0.129; p = 0.020). Uric Acid 112-121 gamma-glutamyltransferase light chain family member 3 Homo sapiens 31-34
21770094-0 2011 Immobilization of uricase enzyme on self-assembled gold nanoparticles for application in uric acid biosensor. Uric Acid 89-98 urate oxidase (pseudogene) Homo sapiens 18-25
21536615-5 2011 Here, we report the case of a girl with severe RHU (serum urate: 5.9 mumol/L [0.1 mg/dL]) associated with recurrent EIARF in whom the disease was caused by a compound heterozygous mutation in SLC2A9, a nonsense mutation in the paternal allele (p.G207X in exon 7), and a large duplication (c.1-2981_1204+16502) in the maternal allele detected by reverse-transcription polymerase chain reaction (PCR), semiquantitative PCR, long PCR, and direct sequencing. Uric Acid 58-63 solute carrier family 2 member 9 Homo sapiens 192-198
21371533-6 2011 Hippocampal CA1 pyramidal neurons treated with caffeine or UA were resistant to oxidant exposure in the slice culture experiments. Uric Acid 59-61 carbonic anhydrase 1 Mus musculus 12-15
21491497-1 2011 Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid using gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide in absence of any cofactor or transition metal. Uric Acid 62-71 urate oxidase (pseudogene) Homo sapiens 29-32
21377455-6 2011 Circulating SLPI showed independent associations with uric acid [beta=5.1 (95% CI 3.4 to 6.7), p<0.00001], serum lipids, pulse pressure and inflammatory markers. Uric Acid 54-63 secretory leukocyte peptidase inhibitor Homo sapiens 12-16
21605422-0 2011 Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression. Uric Acid 135-144 MHC class I polypeptide-related sequence A Homo sapiens 181-185
21605422-10 2011 Allopurinol, an inhibitor of xanthine oxidoreductase that converts xanthine to uric acid, blocked uric acid production, MICA/B expression, and sensitivity to NK-92 cell killing toward a PANC-1 cancer cell line exposed to radiation and two genotoxic drugs, gemcitabine and 5-fluorouracil. Uric Acid 79-88 xanthine dehydrogenase Homo sapiens 29-52
21605422-10 2011 Allopurinol, an inhibitor of xanthine oxidoreductase that converts xanthine to uric acid, blocked uric acid production, MICA/B expression, and sensitivity to NK-92 cell killing toward a PANC-1 cancer cell line exposed to radiation and two genotoxic drugs, gemcitabine and 5-fluorouracil. Uric Acid 98-107 xanthine dehydrogenase Homo sapiens 29-52
21605422-12 2011 DNA damage-induced MICA/B expression is mediated through increased uric acid production. Uric Acid 67-76 MHC class I polypeptide-related sequence A Homo sapiens 19-23
21371533-9 2011 Immunohistochemical analysis showed increased GSH levels in the hippocampal excitatory amino acid carrier-1 (EAAC1)-positive neurons of mice treated with caffeine or UA. Uric Acid 166-168 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 76-107
21371533-9 2011 Immunohistochemical analysis showed increased GSH levels in the hippocampal excitatory amino acid carrier-1 (EAAC1)-positive neurons of mice treated with caffeine or UA. Uric Acid 166-168 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Mus musculus 109-114
21516134-6 2011 RESULTS: Homocysteine, uric acid, high glucose, or oxidized low-density lipoprotein (ox-LDL) down-regulated the chemerin secretion and ChemR23 gene/protein expression in RAECs as a function of concentration and time, which was reversed by pretreatment with iptakalim (1-10 mumol/L). Uric Acid 23-32 retinoic acid receptor responder 2 Rattus norvegicus 112-120
21516134-8 2011 Both iptakalim and recombinant chemerin restored the impaired NO production in RAECs induced by uric acid, and the effects were abolished by anti-ChemR23 antibodies. Uric Acid 96-105 retinoic acid receptor responder 2 Rattus norvegicus 31-39
20947652-3 2011 METHODS: OPN plasma levels obtained during right-sided heart catheterization were assessed by a commercially available enzyme-linked immunosorbent assay and related to hemodynamics, exercise capacity, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) level, uric acid level, C-reactive protein level, and survival in two cohorts of patients with IPAH: a 4-year retrospective cohort (n = 70) and a prospective cohort (n = 25) followed for 3 months after initiation of therapy. Uric Acid 262-271 secreted phosphoprotein 1 Homo sapiens 9-12
21186168-0 2011 Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families. Uric Acid 57-66 solute carrier family 2 member 9 Homo sapiens 20-26
21186168-9 2011 CONCLUSIONS: These findings support two different loci by which SLC2A9 variants affect uric acid levels in African Americans and suggest SLC2A9 variants affect serum uric acid level via renal and extrarenal clearance. Uric Acid 166-175 solute carrier family 2 member 9 Homo sapiens 64-70
21186168-9 2011 CONCLUSIONS: These findings support two different loci by which SLC2A9 variants affect uric acid levels in African Americans and suggest SLC2A9 variants affect serum uric acid level via renal and extrarenal clearance. Uric Acid 166-175 solute carrier family 2 member 9 Homo sapiens 137-143
21350910-6 2011 hURAT1-mediated [(3)H]orotate transport was inhibited strongly by non-labeled (cold) orotate and the uricouric agent benzbromarone, and moderately inhibited by urate, nicotinate, and another uricouric agent, probenecid. Uric Acid 160-165 solute carrier family 22 member 12 Homo sapiens 0-6
21186168-1 2011 OBJECTIVES: SLC2A9 gene variants associate with serum uric acid in white populations, but little is known about African American populations. Uric Acid 54-63 solute carrier family 2 member 9 Homo sapiens 12-18
21186168-2 2011 Since SLC2A9 is a transporter, gene variants may be expected to associate more closely with the fractional excretion of urate, a measure of renal tubular transport, than with serum uric acid, which is influenced by production and extrarenal clearance. Uric Acid 120-125 solute carrier family 2 member 9 Homo sapiens 6-12
21186168-2 2011 Since SLC2A9 is a transporter, gene variants may be expected to associate more closely with the fractional excretion of urate, a measure of renal tubular transport, than with serum uric acid, which is influenced by production and extrarenal clearance. Uric Acid 181-190 solute carrier family 2 member 9 Homo sapiens 6-12
21186168-5 2011 RESULTS: We identified SLC2A9 gene variants that were associated with serum uric acid in 1155 African American subjects (53 SNPs) and 1132 white subjects (63 SNPs). Uric Acid 76-85 solute carrier family 2 member 9 Homo sapiens 23-29
21186168-8 2011 Unexpectedly, SLC2A9 gene variants had stronger associations with serum uric acid than with fractional excretion of urate. Uric Acid 72-81 solute carrier family 2 member 9 Homo sapiens 14-20
21186168-8 2011 Unexpectedly, SLC2A9 gene variants had stronger associations with serum uric acid than with fractional excretion of urate. Uric Acid 116-121 solute carrier family 2 member 9 Homo sapiens 14-20
21186168-9 2011 CONCLUSIONS: These findings support two different loci by which SLC2A9 variants affect uric acid levels in African Americans and suggest SLC2A9 variants affect serum uric acid level via renal and extrarenal clearance. Uric Acid 87-96 solute carrier family 2 member 9 Homo sapiens 64-70
21266577-0 2011 Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation. Uric Acid 0-5 myeloperoxidase Homo sapiens 39-54
21449597-5 2011 The current study utilized Xenopus oocytes expressing human uric acid transporter 1 (hURAT1; SLC22A12) as an in vitro method to investigate novel compounds and their ability to inhibit (14)C-uric acid uptake via hURAT1. Uric Acid 60-69 solute carrier family 22 member 12 Homo sapiens 85-91
21449597-5 2011 The current study utilized Xenopus oocytes expressing human uric acid transporter 1 (hURAT1; SLC22A12) as an in vitro method to investigate novel compounds and their ability to inhibit (14)C-uric acid uptake via hURAT1. Uric Acid 60-69 solute carrier family 22 member 12 Homo sapiens 93-101
21266577-3 2011 Urate was readily oxidized by MPO and hydrogen peroxide to 5-hydroxyisourate, which decayed to predominantly allantoin. Uric Acid 0-5 myeloperoxidase Homo sapiens 30-33
21428959-4 2011 The discovery that NLRP3 (NLR-related protein 3) can recognize host-derived particulate matter such as uric acid and cholesterol crystals has led to this inflammasome being implicated in a number of inflammatory diseases, including gout, atherosclerosis and Type 2 diabetes. Uric Acid 103-112 NLR family pyrin domain containing 3 Homo sapiens 19-24
21266577-4 2011 The redox intermediates of MPO were reduced by urate with rate constants of 4.6 x 10(5) M(-1) s(-1) for compound I and 1.7 x 10(4) M(-1) s(-1) for compound II. Uric Acid 47-52 myeloperoxidase Homo sapiens 27-30
21266577-5 2011 Urate competed with chloride for oxidation by MPO and at hyperuricemic levels is expected to be a substantive substrate for the enzyme. Uric Acid 0-5 myeloperoxidase Homo sapiens 46-49
21266577-7 2011 In combination with superoxide and hydrogen peroxide, MPO oxidized urate to a reactive hydroperoxide. Uric Acid 67-72 myeloperoxidase Homo sapiens 54-57
21266577-9 2011 Urate also enhanced MPO-dependent consumption of nitric oxide. Uric Acid 0-5 myeloperoxidase Homo sapiens 20-23
21266577-11 2011 We propose that urate is a physiological substrate for MPO that is oxidized to the urate radical. Uric Acid 16-21 myeloperoxidase Homo sapiens 55-58
21266577-12 2011 The reactions of this radical with superoxide and nitric oxide provide a plausible link between urate and MPO in cardiovascular disease. Uric Acid 96-101 myeloperoxidase Homo sapiens 106-109
21324323-4 2011 MAIN METHODS: Mass-spectrometric analysis of urinary uric acid, the final purine catabolite, following 1.0 g oral doses of sodium [(13)C] formate was performed and detected (13)C enrichment at C(2) and C(8) separately. Uric Acid 53-62 complement C2 Homo sapiens 193-197
21324323-4 2011 MAIN METHODS: Mass-spectrometric analysis of urinary uric acid, the final purine catabolite, following 1.0 g oral doses of sodium [(13)C] formate was performed and detected (13)C enrichment at C(2) and C(8) separately. Uric Acid 53-62 homeobox C8 Homo sapiens 202-206
21359394-0 2011 Nano-sized platinum as a mimic of uricase catalyzing the oxidative degradation of uric acid. Uric Acid 82-91 urate oxidase (pseudogene) Homo sapiens 34-41
21359394-3 2011 Herein, platinum nanoparticles (PtNPs) were found to be an effective mimic of uricase in the oxidation of UA. Uric Acid 106-108 urate oxidase (pseudogene) Homo sapiens 78-85
21428959-4 2011 The discovery that NLRP3 (NLR-related protein 3) can recognize host-derived particulate matter such as uric acid and cholesterol crystals has led to this inflammasome being implicated in a number of inflammatory diseases, including gout, atherosclerosis and Type 2 diabetes. Uric Acid 103-112 NLR family pyrin domain containing 3 Homo sapiens 26-47
21234729-6 2011 Uric acid crystals also have been shown to trigger interleukin-1beta-mediated inflammation via activation of the NOD-like receptor protein (NLRP)3 inflammasome, a multimolecular complex whose activation appears to be central to many pathological inflammatory conditions. Uric Acid 0-9 interleukin 1 beta Homo sapiens 51-68
21234729-6 2011 Uric acid crystals also have been shown to trigger interleukin-1beta-mediated inflammation via activation of the NOD-like receptor protein (NLRP)3 inflammasome, a multimolecular complex whose activation appears to be central to many pathological inflammatory conditions. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 140-146
21243457-4 2011 This fact, associated with novel insights into the molecular mechanisms activated by the urate crystal deposition, is at the basis of new therapeutics under clinical development for gout, a valid example being the effective targeting of the proinflammatory cytokine interleukin-1. Uric Acid 89-94 interleukin 1 alpha Homo sapiens 266-279
21285172-2 2011 As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. Uric Acid 61-70 adrenoceptor beta 3 Homo sapiens 88-93
21346177-5 2011 RESULTS: Uric acid induced in vitro an increase in the production (mRNA and secreted protein) of monocyte chemotactic protein-1 (MCP-1), an adipokine playing an essential role in inducing the proinflammatory state in adipocytes in obesity. Uric Acid 9-18 chemokine (C-C motif) ligand 2 Mus musculus 97-127
21346177-5 2011 RESULTS: Uric acid induced in vitro an increase in the production (mRNA and secreted protein) of monocyte chemotactic protein-1 (MCP-1), an adipokine playing an essential role in inducing the proinflammatory state in adipocytes in obesity. Uric Acid 9-18 chemokine (C-C motif) ligand 2 Mus musculus 129-134
21346177-6 2011 In addition, uric acid caused a decrease in the production of adiponectin, an adipocyte-specific insulin sensitizer and anti-inflammatory agent. Uric Acid 13-22 adiponectin, C1Q and collagen domain containing Mus musculus 62-73
21346177-7 2011 Uric acid-induced increase in MCP-1 production was blocked by scavenging superoxide or by inhibiting NADPH oxidase and by stimulating peroxisome-proliferator-activated receptor-gamma with rosiglitazone. Uric Acid 0-9 chemokine (C-C motif) ligand 2 Mus musculus 30-35
21346177-7 2011 Uric acid-induced increase in MCP-1 production was blocked by scavenging superoxide or by inhibiting NADPH oxidase and by stimulating peroxisome-proliferator-activated receptor-gamma with rosiglitazone. Uric Acid 0-9 peroxisome proliferator activated receptor gamma Mus musculus 134-182
21346177-10 2011 Lowering uric acid in these mice by inhibiting xanthine oxidoreductase with allopurinol could improve the proinflammatory endocrine imbalance in the adipose tissue by reducing production of MCP-1 and increasing production of adiponectin. Uric Acid 9-18 xanthine dehydrogenase Mus musculus 47-70
21346177-10 2011 Lowering uric acid in these mice by inhibiting xanthine oxidoreductase with allopurinol could improve the proinflammatory endocrine imbalance in the adipose tissue by reducing production of MCP-1 and increasing production of adiponectin. Uric Acid 9-18 chemokine (C-C motif) ligand 2 Mus musculus 190-195
21346177-10 2011 Lowering uric acid in these mice by inhibiting xanthine oxidoreductase with allopurinol could improve the proinflammatory endocrine imbalance in the adipose tissue by reducing production of MCP-1 and increasing production of adiponectin. Uric Acid 9-18 adiponectin, C1Q and collagen domain containing Mus musculus 225-236
20589538-0 2011 Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson"s disease. Uric Acid 17-26 solute carrier family 2 member 9 Homo sapiens 44-50
21607170-0 2011 Relationship between plasma adiponectin, retinol-binding protein 4 and uric Acid in hypertensive patients with metabolic syndrome. Uric Acid 71-80 retinol binding protein 4 Homo sapiens 41-66
21607170-2 2011 To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS. Uric Acid 145-154 adiponectin, C1Q and collagen domain containing Homo sapiens 72-83
21607170-2 2011 To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS. Uric Acid 145-154 retinol binding protein 4 Homo sapiens 88-113
21607170-2 2011 To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS. Uric Acid 145-154 retinol binding protein 4 Homo sapiens 115-119
21607170-7 2011 Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Uric Acid 90-99 adiponectin, C1Q and collagen domain containing Homo sapiens 6-17
21607170-8 2011 Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044). Uric Acid 109-118 retinol binding protein 4 Homo sapiens 42-46
21607170-8 2011 Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044). Uric Acid 109-118 adiponectin, C1Q and collagen domain containing Homo sapiens 51-62
21607170-8 2011 Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044). Uric Acid 109-118 retinol binding protein 4 Homo sapiens 147-151
21607170-8 2011 Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044). Uric Acid 109-118 adiponectin, C1Q and collagen domain containing Homo sapiens 172-183
20091036-6 2011 There were significant correlations between 24-h urinary uric acid excretion and waist circumference (r(2) = 0.225, P = 0.049), fasting insulin (r(2) = 0.241, P = 0.035), and insulin resistance (HOMA-IR) (r(2) = 0.271, P = 0.017). Uric Acid 57-66 insulin Homo sapiens 175-182
21366895-0 2011 Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population. Uric Acid 6-15 solute carrier family 22 member 12 Homo sapiens 42-50
21366895-2 2011 This study examined serum uric acid (SUA) distribution according to SLC22A12 W258X genotype in a general Japanese population. Uric Acid 26-35 solute carrier family 22 member 12 Homo sapiens 68-76
20589538-2 2011 SLC2A9 has been indicated as the most effective of all uric acid transporters, and SLC2A9 variants have been shown to influence circulating uric acid levels. Uric Acid 55-64 solute carrier family 2 member 9 Homo sapiens 0-6
20589538-2 2011 SLC2A9 has been indicated as the most effective of all uric acid transporters, and SLC2A9 variants have been shown to influence circulating uric acid levels. Uric Acid 140-149 solute carrier family 2 member 9 Homo sapiens 83-89
21167141-1 2011 Xanthine oxidase is a key enzyme that catalyses hypoxanthine and xanthine to uric acid and the overproduction of uric acid will lead to hyperuricemia which is an important cause of gout. Uric Acid 77-86 xanthine dehydrogenase Mus musculus 0-16
21294900-13 2011 This finding provides evidence for the role of SLC2A9 in uric acid metabolism across human populations. Uric Acid 57-66 solute carrier family 2 member 9 Homo sapiens 47-53
21167141-1 2011 Xanthine oxidase is a key enzyme that catalyses hypoxanthine and xanthine to uric acid and the overproduction of uric acid will lead to hyperuricemia which is an important cause of gout. Uric Acid 113-122 xanthine dehydrogenase Mus musculus 0-16
20972558-2 2011 Recent genome-wide association studies have shown that ABCG2 transporter modulates serum uric acid (UA) levels. Uric Acid 89-98 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 55-60
20972558-2 2011 Recent genome-wide association studies have shown that ABCG2 transporter modulates serum uric acid (UA) levels. Uric Acid 100-102 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 55-60
21283782-8 2011 Among the loci that showed association in this study, we observed evidence of a possible involvement of the region encompassing the gene LRRC16A, already associated to serum uric acid levels in a large meta-analysis of 14 GWAS, suggesting that this locus might lead a pathway for uric acid metabolism that may be involved in gout as well as in nephrolithiasis. Uric Acid 174-183 capping protein regulator and myosin 1 linker 1 Homo sapiens 137-144
21456131-2 2011 The PArg/MWCNTs/GCE exhibited high electro-catalytic activities towards the oxidation of 3,4-dihydroxyphenylacetic acid (DOPAC), uric acid (UA), and ascorbic acid (AA), and could be sensitively used for simultaneous determination of DOPAC, AA, and UA in pH 7.4 phosphate-buffered solution (PBS).The linear ranges were 7 microM to 2.7 mM for DOPAC, 3 microM to 1.2 mM for UA, and 70 microM to 1.4 mM for AA. Uric Acid 129-138 poly(ADP-ribose) glycohydrolase Homo sapiens 4-8
21456131-2 2011 The PArg/MWCNTs/GCE exhibited high electro-catalytic activities towards the oxidation of 3,4-dihydroxyphenylacetic acid (DOPAC), uric acid (UA), and ascorbic acid (AA), and could be sensitively used for simultaneous determination of DOPAC, AA, and UA in pH 7.4 phosphate-buffered solution (PBS).The linear ranges were 7 microM to 2.7 mM for DOPAC, 3 microM to 1.2 mM for UA, and 70 microM to 1.4 mM for AA. Uric Acid 140-142 poly(ADP-ribose) glycohydrolase Homo sapiens 4-8
21456131-2 2011 The PArg/MWCNTs/GCE exhibited high electro-catalytic activities towards the oxidation of 3,4-dihydroxyphenylacetic acid (DOPAC), uric acid (UA), and ascorbic acid (AA), and could be sensitively used for simultaneous determination of DOPAC, AA, and UA in pH 7.4 phosphate-buffered solution (PBS).The linear ranges were 7 microM to 2.7 mM for DOPAC, 3 microM to 1.2 mM for UA, and 70 microM to 1.4 mM for AA. Uric Acid 248-250 poly(ADP-ribose) glycohydrolase Homo sapiens 4-8
21456131-2 2011 The PArg/MWCNTs/GCE exhibited high electro-catalytic activities towards the oxidation of 3,4-dihydroxyphenylacetic acid (DOPAC), uric acid (UA), and ascorbic acid (AA), and could be sensitively used for simultaneous determination of DOPAC, AA, and UA in pH 7.4 phosphate-buffered solution (PBS).The linear ranges were 7 microM to 2.7 mM for DOPAC, 3 microM to 1.2 mM for UA, and 70 microM to 1.4 mM for AA. Uric Acid 248-250 poly(ADP-ribose) glycohydrolase Homo sapiens 4-8
21272127-3 2011 Human renal urate transporter URAT1 is thought to be an essential molecule that mediates the reabsorption of urate on the apical side of the proximal tubule. Uric Acid 12-17 solute carrier family 22 member 12 Homo sapiens 30-35
21272127-6 2011 RESULTS: MDCK-URAT1 cells exhibited a time- and dose-dependent increase in urate uptake, with a Km value of 570.7 micromol/L. Uric Acid 75-80 solute carrier family 22 member 12 Homo sapiens 14-19
21272127-8 2011 The drugs except for captoril dose-dependently inhibited urate uptake mediated by URAT1, with half maximal inhibitory concentration (IC(50) ) values ranging 0.05-716 micromol/L. Uric Acid 57-62 solute carrier family 22 member 12 Homo sapiens 82-87
21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 40-45
21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 0-9 heat shock protein family B (small) member 3 Homo sapiens 102-111
21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 11-13 NLR family pyrin domain containing 3 Homo sapiens 40-45
21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 11-13 heat shock protein family B (small) member 3 Homo sapiens 102-111
21245324-3 2011 In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1beta. Uric Acid 73-82 interleukin 18 Homo sapiens 127-132
21245324-3 2011 In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1beta. Uric Acid 73-82 interleukin 1 beta Homo sapiens 137-145
21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 34-43 interleukin 18 Homo sapiens 68-73
21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 112-121 interleukin 18 Homo sapiens 68-73
21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 112-121 interleukin 1 beta Homo sapiens 78-86
21041719-10 2011 In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1beta-associated autoinflammatory diseases. Uric Acid 35-44 death associated protein kinase 1 Homo sapiens 13-17
21041719-10 2011 In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1beta-associated autoinflammatory diseases. Uric Acid 35-44 death associated protein kinase 1 Homo sapiens 92-96
21041719-10 2011 In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1beta-associated autoinflammatory diseases. Uric Acid 35-44 interleukin 1 beta Homo sapiens 139-147
21614936-0 2011 SLC22A12 W258X frequency according to serum uric acid level among Japanese health checkup examinees. Uric Acid 44-53 solute carrier family 22 member 12 Homo sapiens 0-8
21614936-1 2011 Although the SLC22A12 (uric acid transporter 1) 258X allele is known to cause hypouricemia, the genotype frequency according to the serum uric acid (SUA) level has not been reported. Uric Acid 23-32 solute carrier family 22 member 12 Homo sapiens 13-21
21614936-12 2011 This study indicated that SLC22A12 258WX was more common among those with a lower serum uric acid concentration. Uric Acid 88-97 solute carrier family 22 member 12 Homo sapiens 26-34
21088975-10 2011 CysC concentration was associated with insulin resistance, alanine aminotransferase, uric acid, and homocysteine after adjusting for age, gender, and eGFR. Uric Acid 85-94 cystatin C Homo sapiens 0-4
20490785-9 2011 Serum testosterone was related to higher urinary excretion of uric acid in ASF patients and to higher urinary excretion of oxalate in the control group. Uric Acid 62-71 arylsulfatase F Homo sapiens 75-78
21283782-8 2011 Among the loci that showed association in this study, we observed evidence of a possible involvement of the region encompassing the gene LRRC16A, already associated to serum uric acid levels in a large meta-analysis of 14 GWAS, suggesting that this locus might lead a pathway for uric acid metabolism that may be involved in gout as well as in nephrolithiasis. Uric Acid 280-289 capping protein regulator and myosin 1 linker 1 Homo sapiens 137-144
22029199-7 2011 A positive correlation was observed between adenosine deaminase and uric acid (r = 0.743, p < 0.001), adenosine deaminase and C-reactive protein (r = 0.648, p < 0.001) and also between C-reactive protein and uric acid (r = 0.712, p < 0.001). Uric Acid 68-77 adenosine deaminase Homo sapiens 44-63
21059659-8 2011 Both ectopic overexpression of XOR cDNA and uric acid supplementation reduced SUMO-PPARgamma in MNP cells. Uric Acid 44-53 peroxisome proliferator-activated receptor gamma Rattus norvegicus 83-92
22009810-2 2011 There is a possible association between ventricular dysfunction following acute myocardial infarction and high Sensitivity C-reactive protein (HS-CRP) and uric acid. Uric Acid 155-164 C-reactive protein Homo sapiens 123-141
21389694-5 2011 RESULTS: Serum uric acid level was significantly increased in all stages of CKD and strongly correlated with estimated glomerular filtration rate (eGFR-MDRD); FMD was inversely associated with serum uric acid (r = -0.49, p < 0.001). Uric Acid 15-24 epidermal growth factor receptor Homo sapiens 147-151
21389694-6 2011 The association of serum uric acid with FMD remained after adjustment for age, gender, smoking, LDL cholesterol, eGFR, high-sensitivity C-reactive protein, systolic blood pressure, proteinuria, and homeostatic model assessment index (beta = -0.27, p < 0.001). Uric Acid 25-34 epidermal growth factor receptor Homo sapiens 113-117
20632067-4 2011 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 73-78
20632067-4 2011 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Uric Acid 13-22 caspase 1 Homo sapiens 114-123
20632067-4 2011 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Uric Acid 13-22 interleukin 1 beta Homo sapiens 151-163
20632067-4 2011 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Uric Acid 13-22 interleukin 1 beta Homo sapiens 155-163
20972595-0 2011 Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method. Uric Acid 57-66 solute carrier family 2 member 9 Homo sapiens 34-40
20972595-1 2011 SLC2A9 is a novel identified urate transporter influencing uric acid metabolism. Uric Acid 59-68 solute carrier family 2 member 9 Homo sapiens 0-6
21062641-12 2011 In the presence of p38-MAPK and Syk inhibitors and monosodium urate crystals, IL-8 release was reduced. Uric Acid 51-67 mitogen-activated protein kinase 14 Homo sapiens 19-22
21062641-12 2011 In the presence of p38-MAPK and Syk inhibitors and monosodium urate crystals, IL-8 release was reduced. Uric Acid 51-67 spleen associated tyrosine kinase Homo sapiens 32-35
21062641-12 2011 In the presence of p38-MAPK and Syk inhibitors and monosodium urate crystals, IL-8 release was reduced. Uric Acid 51-67 C-X-C motif chemokine ligand 8 Homo sapiens 78-82
21325826-6 2011 In addition, prohibitin-2 was identified to be related to renal cell transdifferentiation stimulated by elevated uric acid. Uric Acid 113-122 prohibitin 2 Homo sapiens 13-25
22029199-7 2011 A positive correlation was observed between adenosine deaminase and uric acid (r = 0.743, p < 0.001), adenosine deaminase and C-reactive protein (r = 0.648, p < 0.001) and also between C-reactive protein and uric acid (r = 0.712, p < 0.001). Uric Acid 214-223 adenosine deaminase Homo sapiens 44-63
22029199-7 2011 A positive correlation was observed between adenosine deaminase and uric acid (r = 0.743, p < 0.001), adenosine deaminase and C-reactive protein (r = 0.648, p < 0.001) and also between C-reactive protein and uric acid (r = 0.712, p < 0.001). Uric Acid 214-223 C-reactive protein Homo sapiens 129-147
21244670-9 2011 Finally, urate crystals, which specifically induce the NLPR3 inflammasome activation, induced significant IL-1beta production in healthy controls but not in patients with sepsis. Uric Acid 9-14 interleukin 1 beta Homo sapiens 106-114
21584282-2 2011 The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). Uric Acid 88-97 solute carrier family 2 member 9 Homo sapiens 46-52
21584282-2 2011 The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). Uric Acid 99-101 solute carrier family 2 member 9 Homo sapiens 46-52
21103968-3 2011 OAT4 in the apical membrane of human proximal tubule cells is related to drug exit into the lumen and to uptake of estrone sulfate and urate from the lumen into the cell. Uric Acid 135-140 solute carrier family 22 member 11 Homo sapiens 0-4
21584282-1 2011 AIMS: The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. Uric Acid 109-118 solute carrier family 2 member 9 Homo sapiens 10-16
20472486-7 2011 Genome-wide association scans for genes regulating serum urate concentrations have identified two major regulators of hyperuricaemia- the renal urate transporters SLC2A9 and ABCG2. Uric Acid 57-62 solute carrier family 2 member 9 Homo sapiens 163-169
21282933-2 2011 NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [(14)C]para-aminohippurate, [(3)H]bumetanide, [(3)H]estrone sulfate, and [(14)C]urate, when each variant clone was expressed in the plasma membrane of oocytes. Uric Acid 102-107 solute carrier family 17 member 3 Homo sapiens 0-4
21282933-3 2011 This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate. Uric Acid 218-223 solute carrier family 17 member 3 Homo sapiens 66-70
21103975-9 2011 Recent findings support the notion that the physiological function of ABCG2 is involved in the elimination of uric acid resulting in higher risk for developing gout in male patients harboring genetic variants. Uric Acid 110-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 70-75
22216028-0 2011 Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus. Uric Acid 44-53 insulin Homo sapiens 58-65
32272545-3 2011 This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate. Uric Acid 218-223 solute carrier family 17 member 3 Homo sapiens 66-70
21523662-10 2011 Multiple stepwise regression analysis showed that uric acid level was independently associated with WHR, GFR and CRP. Uric Acid 50-59 C-reactive protein Homo sapiens 113-116
22335090-6 2011 The serum uric acid level was measured by the enzymatic (PAP- Uricase) method. Uric Acid 10-19 urate oxidase (pseudogene) Homo sapiens 62-69
20472486-7 2011 Genome-wide association scans for genes regulating serum urate concentrations have identified two major regulators of hyperuricaemia- the renal urate transporters SLC2A9 and ABCG2. Uric Acid 57-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 174-179
22194975-8 2011 Furthermore, treatment of WT animals with allopurinol, an XDH inhibitor, led to reduced levels of uric acid, oxidative stress, collagen deposition and a downregulation of the NF-kB signaling pathway. Uric Acid 98-107 xanthine dehydrogenase Mus musculus 58-61
22194875-7 2011 This data highlights the importance of the URAT1 renal urate transporter in determining serum urate concentrations and the clinical phenotypes, including nephrolithiasis, that should prompt the clinician to suspect an inherited form of renal hypouricaemia. Uric Acid 55-60 solute carrier family 22 member 12 Homo sapiens 43-48
21915176-4 2011 In mice fed the COCO diet, but not in those fed the LIN diet, PPARalpha deficiency enhanced hepatic GSH content and gammaGCL activity, superoxide dismutase 2 mRNA levels, and plasma uric acid concentration, suggesting an oxidative stress. Uric Acid 182-191 peroxisome proliferator activated receptor alpha Mus musculus 62-71
22195044-1 2011 BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta). Uric Acid 134-150 interleukin 1 beta Homo sapiens 196-213
22195044-1 2011 BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta). Uric Acid 134-150 interleukin 1 beta Homo sapiens 215-223
22195044-1 2011 BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta). Uric Acid 152-155 interleukin 1 beta Homo sapiens 196-213
22195044-1 2011 BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta). Uric Acid 152-155 interleukin 1 beta Homo sapiens 215-223
21886828-1 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far. Uric Acid 107-116 solute carrier family 2 member 9 Homo sapiens 139-145
20931244-6 2010 Furthermore, plasma uric acid was associated significantly with the COMT Val158Met polymorphism. Uric Acid 20-29 catechol-O-methyltransferase Homo sapiens 68-72
21048113-5 2010 Similarly with ATP, knockdown of TRIM30 increased caspase-1 activation and IL-1beta production triggered by other NLRP3 inflammasome agonists, including nigericin, monosodium urate, and silica. Uric Acid 164-180 tripartite motif-containing 30A Mus musculus 33-39
21048113-8 2010 Finally, in a crystal-induced NLRP3 inflammasome-dependent peritonitis model, monosodium urate-induced neutrophil flux and IL-1beta production was reduced significantly in TRIM30 transgenic mice as compared with that in their nontransgenic littermates. Uric Acid 78-94 NLR family, pyrin domain containing 3 Mus musculus 30-35
21048113-8 2010 Finally, in a crystal-induced NLRP3 inflammasome-dependent peritonitis model, monosodium urate-induced neutrophil flux and IL-1beta production was reduced significantly in TRIM30 transgenic mice as compared with that in their nontransgenic littermates. Uric Acid 78-94 tripartite motif-containing 30A Mus musculus 172-178
21077683-0 2010 Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate. Uric Acid 22-27 xanthine dehydrogenase Rattus norvegicus 42-65
21077683-2 2010 In an effort to distinguish between the two models, we determined the crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase at 1.7 A and of the reduced bovine milk enzyme at 2.1 A, the latter representing a reaction intermediate. Uric Acid 96-101 xanthine dehydrogenase Rattus norvegicus 161-184
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 solute carrier family 22 member 11 Homo sapiens 137-145
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 glucokinase regulator Homo sapiens 147-151
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 ras responsive element binding protein 1 Homo sapiens 174-179
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 PDZ domain containing 1 Homo sapiens 181-186
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 solute carrier family 2 member 9 Homo sapiens 188-194
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 196-201
20884846-6 2010 Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4x10(-8) to 2x10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Uric Acid 95-100 solute carrier family 17 member 1 Homo sapiens 207-214
20931244-7 2010 Our study suggests the possible involvement of genetic polymorphisms in COMT and DBH in the regulation of blood pressure and plasma uric acid. Uric Acid 132-141 catechol-O-methyltransferase Homo sapiens 72-76
20931244-7 2010 Our study suggests the possible involvement of genetic polymorphisms in COMT and DBH in the regulation of blood pressure and plasma uric acid. Uric Acid 132-141 dopamine beta-hydroxylase Homo sapiens 81-84
20855893-5 2010 GCK inactivation and down-regulation were predominantly mediated by ethanol metabolism-generated peroxynitrite, which were suppressed by the peroxynitrite scavengers N(gamma)-monomethyl-L-arginine, uric acid, and deferoxamine but not by the S-nitrosylation inhibitor DTT, indicating that tyrosine nitration is the predominant modification associated with GCK down-regulation and inactivation rather than S-nitrosylation of cysteine. Uric Acid 198-207 glucokinase Homo sapiens 0-3
21119573-6 2010 AST showed a significant correlation with Tn I, uric acid and leukocyte count in the overall population and in non-diabetic patients. Uric Acid 48-57 solute carrier family 17 member 5 Homo sapiens 0-3
21119573-8 2010 CONCLUSIONS: In 1000 consecutive STEMI patients submitted to mechanical revascularization, admission ALT and AST were independent predictors for in-ICCU mortality and complications in non-diabetic patients, being strictly related to infarct size (as indicated by peak Tn I), the degree of inflammatory activation (as inferred by leukocytes) and prognostic markers (NT-pro-BNP and uric acid). Uric Acid 380-389 solute carrier family 17 member 5 Homo sapiens 109-112
20855893-5 2010 GCK inactivation and down-regulation were predominantly mediated by ethanol metabolism-generated peroxynitrite, which were suppressed by the peroxynitrite scavengers N(gamma)-monomethyl-L-arginine, uric acid, and deferoxamine but not by the S-nitrosylation inhibitor DTT, indicating that tyrosine nitration is the predominant modification associated with GCK down-regulation and inactivation rather than S-nitrosylation of cysteine. Uric Acid 198-207 glucokinase Homo sapiens 355-358
20705636-4 2010 It highlights the evidence suggesting that monosodium urate crystal deposition is associated with the presence of underlying osteoarthritis and the important role of osteoclasts and the receptor for activation of nuclear factor kappa B (RANK) and RANK ligand (RANK-RANKL) pathway in the pathogenesis of gouty erosions. Uric Acid 43-59 TNF superfamily member 11 Homo sapiens 265-270
20810651-0 2010 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. Uric Acid 103-108 solute carrier family 17 member 3 Homo sapiens 38-43
20810651-0 2010 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. Uric Acid 103-108 solute carrier family 17 member 3 Homo sapiens 44-51
20810651-1 2010 The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated serum uric acid (urate). Uric Acid 100-109 urate oxidase (pseudogene) Homo sapiens 48-55
20810651-1 2010 The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated serum uric acid (urate). Uric Acid 33-38 urate oxidase (pseudogene) Homo sapiens 48-55
20810651-5 2010 Renal urate reabsorption is controlled via two proximal tubular urate transporters: apical URAT1 (SLC22A12) and basolateral URATv1/GLUT9 (SLC2A9). Uric Acid 6-11 solute carrier family 22 member 12 Homo sapiens 91-96
20810651-5 2010 Renal urate reabsorption is controlled via two proximal tubular urate transporters: apical URAT1 (SLC22A12) and basolateral URATv1/GLUT9 (SLC2A9). Uric Acid 6-11 solute carrier family 22 member 12 Homo sapiens 98-106
20810651-5 2010 Renal urate reabsorption is controlled via two proximal tubular urate transporters: apical URAT1 (SLC22A12) and basolateral URATv1/GLUT9 (SLC2A9). Uric Acid 6-11 solute carrier family 2 member 9 Homo sapiens 124-130
20810651-5 2010 Renal urate reabsorption is controlled via two proximal tubular urate transporters: apical URAT1 (SLC22A12) and basolateral URATv1/GLUT9 (SLC2A9). Uric Acid 6-11 solute carrier family 2 member 9 Homo sapiens 131-136
20810651-5 2010 Renal urate reabsorption is controlled via two proximal tubular urate transporters: apical URAT1 (SLC22A12) and basolateral URATv1/GLUT9 (SLC2A9). Uric Acid 6-11 solute carrier family 2 member 9 Homo sapiens 138-144
20810651-12 2010 These mutated versions of hNPT4 exhibited reduced urate efflux when they were expressed in Xenopus oocytes. Uric Acid 50-55 solute carrier family 17 member 3 Homo sapiens 26-31
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 38-43 solute carrier family 22 member 6 Homo sapiens 120-124
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 38-43 solute carrier family 22 member 8 Homo sapiens 132-136
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 38-43 solute carrier family 17 member 3 Homo sapiens 191-196
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 101-106 solute carrier family 22 member 6 Homo sapiens 120-124
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 101-106 solute carrier family 22 member 8 Homo sapiens 132-136
20810651-13 2010 Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. Uric Acid 101-106 solute carrier family 17 member 3 Homo sapiens 191-196
20627967-1 2010 Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its gene during the Miocene epoch, which led to humans having higher UA levels than other mammals. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 84-91
21116779-2 2010 Herein, a new practical system was investigated to evaluate the pharmacological significance of a bacterial uricase based on its ability to eliminate uric acid in plasma in vitro, its pharmacokinetics in vivo in healthy rats, and the modeled pharmacodynamics in vivo. Uric Acid 150-159 urate oxidase Rattus norvegicus 108-115
21116779-3 2010 This uricase, before and after modification with the monomethyl ether of poly(ethylene glycol)-5000, effectively eliminated uric acid in vitro in rabbit plasma, but its action was susceptible to xanthine inhibition. Uric Acid 124-133 uricase Oryctolagus cuniculus 5-12
21116779-5 2010 Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Uric Acid 36-45 urate oxidase Rattus norvegicus 77-84
21116779-5 2010 Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Uric Acid 36-45 urate oxidase Rattus norvegicus 184-191
21116779-5 2010 Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Uric Acid 36-45 urate oxidase Rattus norvegicus 184-191
20588307-4 2010 We assessed associations between serum urate levels and 97 SNPs in a positional candidate gene, SLC2A9. Uric Acid 39-44 solute carrier family 2 member 9 Homo sapiens 96-102
20588307-6 2010 SNP genotyping identified significant association between six SNP variants in SLC2A9 and serum urate levels. Uric Acid 95-100 solute carrier family 2 member 9 Homo sapiens 78-84
20588307-9 2010 Our study results implicate genetic variation in SLC2A9 in influencing levels of serum urate over a broad range of values in a large Mauritian family cohort. Uric Acid 87-92 solute carrier family 2 member 9 Homo sapiens 49-55
20662061-0 2010 Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Uric Acid 121-149 toll-like receptor 2 Mus musculus 31-51
20662061-0 2010 Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Uric Acid 121-149 interleukin 1 beta Mus musculus 59-76
20662061-0 2010 Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Uric Acid 121-149 steroid sulfatase Mus musculus 96-99
20662061-0 2010 Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Uric Acid 121-149 caspase 1 Mus musculus 100-109
20627967-1 2010 Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its gene during the Miocene epoch, which led to humans having higher UA levels than other mammals. Uric Acid 11-13 urate oxidase (pseudogene) Homo sapiens 84-91
20627967-1 2010 Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase activity by various mutations of its gene during the Miocene epoch, which led to humans having higher UA levels than other mammals. Uric Acid 194-196 urate oxidase (pseudogene) Homo sapiens 84-91
21063041-1 2010 AIM: to obtain prevalence of insulin resistance among siblings of subjects with type 2 DM and their metabolic abnormality profiles as measured by their BMI, waist circumference (WC), blood pressure, glucose intolerance, concentration of triglyceride, HDL cholesterol, and uric acid. Uric Acid 272-281 insulin Homo sapiens 29-36
20692340-3 2010 To evaluate the applicability of this method to gene targeting in another insect, we mutagenized the Bombyx mori epidermal color marker gene BmBLOS2, which controls the formation of uric acid granules in the larval epidermis. Uric Acid 182-191 biogenesis of lysosome-related organelles complex 1 subunit 2 Bombyx mori 141-148
20878016-9 2010 Noncrystalline UrAc did not induce necrosis or apoptosis, but significantly increased COX-2 and PGE2 production. Uric Acid 15-19 prostaglandin-endoperoxide synthase 2 Canis lupus familiaris 86-91
20598782-7 2010 CONCLUSIONS: The syndrome of inappropriate secretion of antidiuretic hormone is associated with a lower plasma uric acid concentration, but in routine clinical practice, contrary to what has been previously published, this difference is insufficient for hypouricemia to discriminate reliably between the syndrome of inappropriate secretion of antidiuretic hormone and other causes of hyponatremia. Uric Acid 111-120 arginine vasopressin Homo sapiens 56-76
20837191-10 2010 Genetic variants within a newly identified transport gene, SLC2A9, have been associated with a low fractional excretion of uric acid and the presence of gout in several population samples. Uric Acid 123-132 solute carrier family 2 member 9 Homo sapiens 59-65
20837191-13 2010 Introduction of a mutation encoded in a model system by a common single nucleotide polymorphism, rs2231142, resulted in a 53% reduction in urate transport rates compared with wild-type ABCG2. Uric Acid 139-144 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 185-190
20885365-6 2010 Associations with other systemic derangements, including endothelial dysfunction, low-level systemic inflammation, sympathetic overactivity and insulin resistance, render uric acid to a complex but potentially direct causal role in the pathogenesis of hypertension. Uric Acid 171-180 insulin Homo sapiens 144-151
20806936-0 2010 Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors. Uric Acid 67-76 xanthine dehydrogenase Mus musculus 132-148
20566587-0 2010 Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Uric Acid 42-51 fibroblast growth factor 21 Homo sapiens 119-146
20522787-2 2010 We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal activating Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in lung inflammation and fibrosis (Gasse et al., Am J Respir Crit Care Med 2009;179:903-913). Uric Acid 92-101 interferon activated gene 208 Mus musculus 158-183
20522787-2 2010 We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal activating Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in lung inflammation and fibrosis (Gasse et al., Am J Respir Crit Care Med 2009;179:903-913). Uric Acid 92-101 NLR family, pyrin domain containing 3 Mus musculus 185-190
20615869-7 2010 For the orientation of hypoxanthine with C-2 proximal to the molybdenum center, the disposition of substrate in the active site is such that Arg(880) and Glu(802), previous shown to be catalytically important for the conversion of xanthine to uric acid, play similar roles in hydroxylation at C-2 as at C-8. Uric Acid 243-252 complement C2 Bos taurus 41-44
20337611-0 2010 Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Uric Acid 98-107 heart and neural crest derivatives expressed 2 Mus musculus 29-32
20337611-11 2010 CONCLUSION: These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung. Uric Acid 118-127 heart and neural crest derivatives expressed 2 Mus musculus 67-70
20823251-1 2010 With the notable exception of humans, uric acid is degraded to (S)-allantoin in a biochemical pathway catalyzed by urate oxidase, 5-hydroxyisourate (HIU) hydrolase, and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase in most vertebrate species. Uric Acid 38-47 urate oxidase Mus musculus 115-128
20823251-2 2010 A point mutation in the gene encoding mouse HIU hydrolase, Urah, that perturbed uric acid metabolism within the liver was discovered during a mutagenesis screen in mice. Uric Acid 80-89 urate (5-hydroxyiso-) hydrolase Mus musculus 44-57
20823251-2 2010 A point mutation in the gene encoding mouse HIU hydrolase, Urah, that perturbed uric acid metabolism within the liver was discovered during a mutagenesis screen in mice. Uric Acid 80-89 urate (5-hydroxyiso-) hydrolase Mus musculus 59-63
20823251-6 2010 The development of hepatomegaly and liver tumors in mice lacking Urah suggests that uric acid metabolites may be toxic and that urate oxidase activity without HIU hydrolase function may affect liver growth and transformation. Uric Acid 84-93 urate (5-hydroxyiso-) hydrolase Mus musculus 65-69
20823251-7 2010 The absence of HIU hydrolase in humans predicts slowed metabolism of HIU after clinical administration of exogenous urate oxidase in conditions of uric acid-related pathology. Uric Acid 147-156 urate oxidase Mus musculus 116-129
20566587-12 2010 CONCLUSION: Serum FGF21 levels are influenced by BMI, fasting glycemia, uric acid, and physical activity. Uric Acid 72-81 fibroblast growth factor 21 Homo sapiens 18-23
20613716-1 2010 Genetic variation in the SLC2A9 gene is a new genetic risk factor for low fractional excretion of uric acid, hyperuricemia, and gout. Uric Acid 98-107 solute carrier family 2 member 9 Homo sapiens 25-31
20537997-7 2010 RESULTS: GGT activity was heritable at 49% +/- 8% of the twin cohort and had significant covariance with IR; insulin, triglyceride, and uric acid levels; and diastolic blood pressure. Uric Acid 136-145 inactive glutathione hydrolase 2 Homo sapiens 9-12
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 solute carrier family 17 member 1 Homo sapiens 200-207
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 solute carrier family 17 member 3 Homo sapiens 209-216
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 solute carrier family 22 member 11 Homo sapiens 218-226
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 solute carrier family 22 member 12 Homo sapiens 228-236
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 solute carrier family 16 member 9 Homo sapiens 238-245
20613716-3 2010 Follow-up meta-analyses, including one with data from 28,141 individuals, implicated a total of nine additional loci influencing serum urate concentrations, including six other membrane transporters (SLC17A1, SLC17A3, SLC22A11, SLC22A12, SLC16A9, and ABCG2). Uric Acid 135-140 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 251-256
20613716-4 2010 Variants in these genes together account for about 5% of the variance in serum urate, two-thirds of which is due to SLC2A9. Uric Acid 79-84 solute carrier family 2 member 9 Homo sapiens 116-122
20495830-6 2010 Angiogenin correlated with BMI, waist circumference, visceral fat, uric acid, and patients with cIMT>2SD had greater concentration of angiogenin than those with normal cIMT (p = 0.03). Uric Acid 67-76 angiogenin Homo sapiens 0-10
20607198-9 2010 In the diabetes + urate group, the nitration level of COX-2 and iNOS decreased and their binding reduced, consistent with their decreased activity and the attenuated pathological changes in the rat aorta and glomerulus. Uric Acid 18-23 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-59
20607198-9 2010 In the diabetes + urate group, the nitration level of COX-2 and iNOS decreased and their binding reduced, consistent with their decreased activity and the attenuated pathological changes in the rat aorta and glomerulus. Uric Acid 18-23 nitric oxide synthase 2 Rattus norvegicus 64-68
20566650-0 2010 Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. Uric Acid 85-90 solute carrier family 17 member 1 Homo sapiens 47-54
20566650-4 2010 We found that NPT1 also transported urate. Uric Acid 36-41 solute carrier family 17 member 1 Homo sapiens 14-18
20566650-7 2010 Heterologously expressed and purified human NPT1 carrying the single nucleotide polymorphism mutation that is associated with increased risk of gout in humans exhibited 32% lower urate transport activity compared with the wild type protein. Uric Acid 179-184 solute carrier family 17 member 1 Homo sapiens 44-48
20484295-0 2010 Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells. Uric Acid 0-9 fibronectin 1 Rattus norvegicus 20-31
20484295-0 2010 Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells. Uric Acid 0-9 lysyl oxidase Rattus norvegicus 66-79
20484295-9 2010 Upregulation of the urate transporter URAT1, which is located in the apical membrane of proximal tubules, sensitized the uric acid-induced fibronectin and LOX induction, while both knocking down URAT1 expression in tubular epithelial cells by RNA interference and inhibiting URAT1 function pharmacologically attenuated LOX and fibronectin expression. Uric Acid 121-130 lysyl oxidase Rattus norvegicus 319-322
20484295-8 2010 In vitro, uric acid significantly induced NRK-52E cells to express the ECM marker fibronectin, as well as LOX, which plays a pivotal role in ECM maturation, in a time- and dose-dependent manner. Uric Acid 10-19 fibronectin 1 Rattus norvegicus 82-93
20484295-9 2010 Upregulation of the urate transporter URAT1, which is located in the apical membrane of proximal tubules, sensitized the uric acid-induced fibronectin and LOX induction, while both knocking down URAT1 expression in tubular epithelial cells by RNA interference and inhibiting URAT1 function pharmacologically attenuated LOX and fibronectin expression. Uric Acid 121-130 fibronectin 1 Rattus norvegicus 327-338
20484295-10 2010 Furthermore, knockdown of LOX expression by a small interfering RNA strategy led to a decrease in fibronectin abundance induced by uric acid treatment. Uric Acid 131-140 lysyl oxidase Rattus norvegicus 26-29
20484295-8 2010 In vitro, uric acid significantly induced NRK-52E cells to express the ECM marker fibronectin, as well as LOX, which plays a pivotal role in ECM maturation, in a time- and dose-dependent manner. Uric Acid 10-19 lysyl oxidase Rattus norvegicus 106-109
20484295-10 2010 Furthermore, knockdown of LOX expression by a small interfering RNA strategy led to a decrease in fibronectin abundance induced by uric acid treatment. Uric Acid 131-140 fibronectin 1 Rattus norvegicus 98-109
20484295-9 2010 Upregulation of the urate transporter URAT1, which is located in the apical membrane of proximal tubules, sensitized the uric acid-induced fibronectin and LOX induction, while both knocking down URAT1 expression in tubular epithelial cells by RNA interference and inhibiting URAT1 function pharmacologically attenuated LOX and fibronectin expression. Uric Acid 121-130 fibronectin 1 Rattus norvegicus 139-150
20484295-9 2010 Upregulation of the urate transporter URAT1, which is located in the apical membrane of proximal tubules, sensitized the uric acid-induced fibronectin and LOX induction, while both knocking down URAT1 expression in tubular epithelial cells by RNA interference and inhibiting URAT1 function pharmacologically attenuated LOX and fibronectin expression. Uric Acid 121-130 lysyl oxidase Rattus norvegicus 155-158
20601632-5 2010 Low-molecular-weight antioxidants, such as ascorbate, glutathione, and urate, present in the lung epithelial lining fluid and tissue, remove Cl(2) and HOCl and thus decrease injury to critical target biological targets. Uric Acid 71-76 endogenous retrovirus group W member 5 Homo sapiens 141-146
20367113-0 2010 An amperomertic uric acid biosensor based on immobilization of uricase onto polyaniline-multiwalled carbon nanotube composite film. Uric Acid 16-25 urate oxidase (pseudogene) Homo sapiens 63-70
20367113-2 2010 A uric acid biosensor was constructed after immobilization of uricase onto a polyaniline/CNT matrix by carbonamide linkage. Uric Acid 2-11 urate oxidase (pseudogene) Homo sapiens 62-69
20683957-1 2010 UNLABELLED: Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. Uric Acid 27-36 insulin Homo sapiens 103-110
20683957-1 2010 UNLABELLED: Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. Uric Acid 38-40 insulin Homo sapiens 103-110
20683957-4 2010 We also used cross-sectional data from NHANES 1988-1994 (n = 10,993) and NHANES 1999-2006 (n = 6186) to determine whether the serum UA level was associated with elevated serum alanine aminotransferase (ALT) or gamma-glutamyl transferase (GGT), two markers of hepatic necroinflammation. Uric Acid 132-134 glutamic--pyruvic transaminase Homo sapiens 176-200
20683957-6 2010 A higher serum UA level was associated with greater mean serum ALT and GGT levels and a greater probability of elevated serum ALT and GGT. Uric Acid 15-17 gamma-glutamyltransferase 1 Homo sapiens 71-74
20683957-6 2010 A higher serum UA level was associated with greater mean serum ALT and GGT levels and a greater probability of elevated serum ALT and GGT. Uric Acid 15-17 gamma-glutamyltransferase 1 Homo sapiens 134-137
20506351-0 2010 Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Uric Acid 61-77 NLR family, pyrin domain containing 3 Mus musculus 42-51
20506351-0 2010 Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Uric Acid 61-77 NLR family, pyrin domain containing 3 Mus musculus 52-57
20506351-1 2010 OBJECTIVE: The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown. Uric Acid 34-62 NLR family, pyrin domain containing 3 Mus musculus 107-116
20506351-1 2010 OBJECTIVE: The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown. Uric Acid 64-67 NLR family, pyrin domain containing 3 Mus musculus 107-116
20558836-0 2010 Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells. Uric Acid 8-17 angiotensinogen Homo sapiens 61-75
20558836-8 2010 UA (10 mg/dL) for 12 h significantly increased AII protein synthesis and ET-1 expression and protein production was increased after 24 h. Furthermore, UA increased [Ca(2+)](i), and this effect was significantly blocked when ihMCs were preincubated with losartan. Uric Acid 0-2 angiotensinogen Homo sapiens 47-50
20558836-8 2010 UA (10 mg/dL) for 12 h significantly increased AII protein synthesis and ET-1 expression and protein production was increased after 24 h. Furthermore, UA increased [Ca(2+)](i), and this effect was significantly blocked when ihMCs were preincubated with losartan. Uric Acid 0-2 endothelin 1 Homo sapiens 73-77
20558836-8 2010 UA (10 mg/dL) for 12 h significantly increased AII protein synthesis and ET-1 expression and protein production was increased after 24 h. Furthermore, UA increased [Ca(2+)](i), and this effect was significantly blocked when ihMCs were preincubated with losartan. Uric Acid 151-153 angiotensinogen Homo sapiens 47-50
20558836-8 2010 UA (10 mg/dL) for 12 h significantly increased AII protein synthesis and ET-1 expression and protein production was increased after 24 h. Furthermore, UA increased [Ca(2+)](i), and this effect was significantly blocked when ihMCs were preincubated with losartan. Uric Acid 151-153 endothelin 1 Homo sapiens 73-77
20558836-9 2010 Our results suggested that UA triggers reactions including AII and ET-1 production in mesangial cells. Uric Acid 27-29 angiotensinogen Homo sapiens 59-62
20558836-9 2010 Our results suggested that UA triggers reactions including AII and ET-1 production in mesangial cells. Uric Acid 27-29 endothelin 1 Homo sapiens 67-71
20502971-2 2010 Uric acid crystals, first sensed extracellularly by membrane lipid alterations, are internalized and subsequently activate the NLRP3 inflammasome. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 127-132
20421215-0 2010 The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. Uric Acid 59-68 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 29-34
20421215-1 2010 OBJECTIVES: Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks. Uric Acid 194-203 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 86-91
20421215-1 2010 OBJECTIVES: Recent genome-wide association and functional studies have shown that the ABCG2 gene encodes for a urate transporter, and a common causal ABCG2 variant, rs2231142, leads to elevated uric acid levels and prevalent gout among Whites and Blacks. Uric Acid 194-203 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 150-155
20421215-10 2010 CONCLUSIONS: The association of the causal ABCG2 rs2231142 variant with uric acid levels and gout was confirmed in a sample of Japanese ancestry. Uric Acid 72-81 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 43-48
21200101-10 2010 Serum GGT level was moderately but significantly correlated with waist circumference (r=0.2, p=0.04), uric acid (r=0.3, p=0.008), and hs-CRP (r=0.3, p=0.002). Uric Acid 102-111 gamma-glutamyltransferase light chain family member 3 Homo sapiens 6-9
20197412-3 2010 SLC2A9, a urate transporter, influences uric acid levels. Uric Acid 40-49 solute carrier family 2 member 9 Homo sapiens 0-6
19556210-2 2010 Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular cells to urine. Uric Acid 78-83 solute carrier family 17 member 1 Homo sapiens 65-72
20053405-2 2010 Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels. Uric Acid 91-100 solute carrier family 2 member 9 Homo sapiens 13-19
20053405-2 2010 Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels. Uric Acid 91-100 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 21-26
20053405-2 2010 Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels. Uric Acid 91-100 solute carrier family 17 member 3 Homo sapiens 32-39
20053405-4 2010 RESULTS: Each copy of the minor allele decreased uric acid levels by 0.30-0.38 mg/dL for SLC2A9 (p values: 10(-20)-10(-36)) and increased levels by 0.34 mg/dL for ABCG2 (p=1.1x10(-16)). Uric Acid 49-58 solute carrier family 2 member 9 Homo sapiens 89-95
20053405-4 2010 RESULTS: Each copy of the minor allele decreased uric acid levels by 0.30-0.38 mg/dL for SLC2A9 (p values: 10(-20)-10(-36)) and increased levels by 0.34 mg/dL for ABCG2 (p=1.1x10(-16)). Uric Acid 49-58 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 163-168
20053405-5 2010 SLC17A3 influenced uric acid levels only modestly. Uric Acid 19-28 solute carrier family 17 member 3 Homo sapiens 0-7
20053405-7 2010 In addition, we observed a sex-specific interaction of age with the association of SLC2A9 SNPs with uric acid levels, where increasing age strengthened the association of SNPs in women and decreased the association in men. Uric Acid 100-109 solute carrier family 2 member 9 Homo sapiens 83-89
20053405-8 2010 CONCLUSIONS: Genetic variants within SLC2A9,ABCG2 and SLC17A3 show highly significant associations with uric acid levels, and for SNPs within SLC2A9 this association is strongly modified by age and sex. Uric Acid 104-113 solute carrier family 2 member 9 Homo sapiens 37-43
20053405-8 2010 CONCLUSIONS: Genetic variants within SLC2A9,ABCG2 and SLC17A3 show highly significant associations with uric acid levels, and for SNPs within SLC2A9 this association is strongly modified by age and sex. Uric Acid 104-113 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 44-49
20053405-8 2010 CONCLUSIONS: Genetic variants within SLC2A9,ABCG2 and SLC17A3 show highly significant associations with uric acid levels, and for SNPs within SLC2A9 this association is strongly modified by age and sex. Uric Acid 104-113 solute carrier family 17 member 3 Homo sapiens 54-61
20362027-3 2010 D-GalN rats exhibited an increased hepato and nephro toxicity marker activities aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transpeptidase and total bilirubin level while urea, uric acid and creatinine and lipid profile. Uric Acid 227-236 galanin and GMAP prepropeptide Rattus norvegicus 2-6
20567098-3 2010 Factors predisposing to the development of TLS include a higher growth rate of cancerous cells, a higher sensitivity to chemotherapy, impaired renal function before chemotherapy, elevated lactate dehydrogenase and uric acid serum levels, and a large tumor burden such as huge mass formation and extensive bone marrow involvement. Uric Acid 214-223 FUS RNA binding protein Homo sapiens 43-46
20567098-4 2010 Patients with TLS should be treated carefully with proper fluid management, urinary alkalization, correction of acidosis and electrolyte unbalance, inhibition of the formation of uric acid or destruction of the already circulating uric acid molecules, and a reduction of chemotherapy intensity. Uric Acid 179-188 FUS RNA binding protein Homo sapiens 14-17
20567098-4 2010 Patients with TLS should be treated carefully with proper fluid management, urinary alkalization, correction of acidosis and electrolyte unbalance, inhibition of the formation of uric acid or destruction of the already circulating uric acid molecules, and a reduction of chemotherapy intensity. Uric Acid 231-240 FUS RNA binding protein Homo sapiens 14-17
20470787-11 2010 Changes in the expression of TNF-alpha, IL-2 and IL-6 were detected in the SHR-UA group. Uric Acid 79-81 tumor necrosis factor Rattus norvegicus 29-38
20470787-11 2010 Changes in the expression of TNF-alpha, IL-2 and IL-6 were detected in the SHR-UA group. Uric Acid 79-81 interleukin 2 Rattus norvegicus 40-44
20470787-11 2010 Changes in the expression of TNF-alpha, IL-2 and IL-6 were detected in the SHR-UA group. Uric Acid 79-81 interleukin 6 Rattus norvegicus 49-53
20203626-0 2010 Serum uric acid levels and renal damage in hyperuricemic hypertensive patients treated with renin-angiotensin system blockers. Uric Acid 6-15 renin Homo sapiens 92-97
20197412-4 2010 This study first tested four SLC2A9 SNPs, previously associated with uric acid levels, in approximately 1000 Scots: the Lothian Birth Cohort 1936 (LBC1936). Uric Acid 69-78 solute carrier family 2 member 9 Homo sapiens 29-35
20516647-5 2010 We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development. Uric Acid 196-205 solute carrier family 2 member 9 Homo sapiens 95-101
20348110-0 2010 Bayesian methods for instrumental variable analysis with genetic instruments ("Mendelian randomization"): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome. Uric Acid 119-124 solute carrier family 2 member 9 Homo sapiens 137-143
20516647-5 2010 We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development. Uric Acid 196-205 solute carrier family 2 member 9 Homo sapiens 156-161
20486275-0 2010 Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. Uric Acid 130-139 renin Homo sapiens 43-48
20235627-4 2010 Linear regression analysis showed that log(IFN-alpha production) was positively correlated with log(triglyceride) (r = 0.088, P = 0.03) and uric acid (r = 0.091, P = 0.03), and negatively correlated with age (r = -0.158, P = 0.0001) and FPG (r = -0.088, P = 0.03). Uric Acid 140-149 interferon alpha 1 Homo sapiens 43-52
20486275-11 2010 Uric acid also upregulated the expression of angiotensinogen, angiotensin-converting enzyme and angiotensin II receptors and increased angiotensin II levels, which was ameliorated with tempol. Uric Acid 0-9 angiotensinogen Homo sapiens 45-60
20486275-11 2010 Uric acid also upregulated the expression of angiotensinogen, angiotensin-converting enzyme and angiotensin II receptors and increased angiotensin II levels, which was ameliorated with tempol. Uric Acid 0-9 angiotensinogen Homo sapiens 96-110
20486275-11 2010 Uric acid also upregulated the expression of angiotensinogen, angiotensin-converting enzyme and angiotensin II receptors and increased angiotensin II levels, which was ameliorated with tempol. Uric Acid 0-9 angiotensinogen Homo sapiens 135-149
20486275-12 2010 CONCLUSION: Uric acid-induced aging and death of human endothelial cells are medicated by local activation of oxidative stress and the renin-angiotensin system, which provides a novel mechanism of uric acid-induced endothelial dysfunction. Uric Acid 12-21 renin Homo sapiens 135-140
20486275-12 2010 CONCLUSION: Uric acid-induced aging and death of human endothelial cells are medicated by local activation of oxidative stress and the renin-angiotensin system, which provides a novel mechanism of uric acid-induced endothelial dysfunction. Uric Acid 197-206 renin Homo sapiens 135-140
20215410-6 2010 UA (100 microM) in the presence of the uricase inhibitor oxonic acid (10 microM) did not modify relaxation to acetylcholine (ACh) (1 nM-10 microM) in the aorta from nontreated, sham normotensive, and DOCA-salt hypertensive rats [response to 10 microM ACh for UA versus vehicle, respectively: nontreated = 37 +/- 7 versus 48 +/- 7%, sham = 53 +/- 15 versus 57 +/- 20%, DOCA = 81 +/- 4 versus 85 +/- 2% from 20 microM prostaglandin 2alpha (PGF(2alpha))-induced contraction]. Uric Acid 0-2 urate oxidase Rattus norvegicus 39-46
20144598-0 2010 Mutation -538 T/C in bone morphogenetic protein 4 do not increase the risk in sickle-cell disease with orthopedic complications but strongly associated with increased LDH and uric acid level in Indian patients from Chhattisgarh and Jharkhand states. Uric Acid 175-184 bone morphogenetic protein 4 Homo sapiens 21-49
19155075-8 2010 Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP. Uric Acid 18-27 natriuretic peptide A Homo sapiens 82-85
19155075-8 2010 Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP. Uric Acid 18-27 natriuretic peptide B Homo sapiens 90-93
20544510-1 2010 Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of enzyme deficiency. Uric Acid 133-142 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 62-66
19922966-7 2010 A longitudinal increase in GGT as a time-dependent variable as well as a non-time-dependent variable was significantly related to MetS after adjusting for age plus the elapsed time from visit 1 to visit 2, baseline MetS traits, uric acid, regular exercise, alcohol consumption, and smoking. Uric Acid 228-237 gamma-glutamyltransferase light chain family member 3 Homo sapiens 27-30
19723617-0 2010 Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders. Uric Acid 76-85 solute carrier family 2 member 9 Homo sapiens 44-50
19723617-1 2010 OBJECTIVE: To study the associations of gout, tophi and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single nucleotide polymorphisms (SNPs) between two different racial groups. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 95-101
19723617-1 2010 OBJECTIVE: To study the associations of gout, tophi and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single nucleotide polymorphisms (SNPs) between two different racial groups. Uric Acid 56-65 solute carrier family 2 member 9 Homo sapiens 103-136
19723617-7 2010 CONCLUSION: Non-synonymous SNP rs3733591 variant within the SLC2A9 gene from two geographically diverse populations served as an important genetic checkpoint for tophaceous gout and increased uric acid levels. Uric Acid 192-201 solute carrier family 2 member 9 Homo sapiens 60-66
20450721-10 2010 After adjusting for age, duration of diabetes mellitus, smoking status, systolic blood pressure, body mass index, total cholesterol, triglyceride and C reactive protein, the serum UA levels in women was an independent risk factor associated with the prevalence of LEAD. Uric Acid 180-182 C-reactive protein Homo sapiens 150-168
19962451-9 2010 Finally, we found that decreasing peroxynitrite levels with either uric acid or Manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (MnTymPyp) significantly attenuated the lung leak associated with LPS-exposure in mice suggesting a key role for protein nitration in the progression of ALI. Uric Acid 67-76 toll-like receptor 4 Mus musculus 202-205
20139920-8 2010 There was a strong negative correlation between serum uric acid and YKL-40 concentration at baseline (r=-0.77, P=0.01). Uric Acid 54-63 chitinase 3 like 1 Homo sapiens 68-74
20351688-3 2010 This synthetic device consists of a modified Deinococcus radiodurans-derived protein that senses uric acids levels and triggers dose-dependent derepression of a secretion-engineered Aspergillus flavus urate oxidase that eliminates uric acid. Uric Acid 97-107 urate oxidase Mus musculus 201-214
20351688-3 2010 This synthetic device consists of a modified Deinococcus radiodurans-derived protein that senses uric acids levels and triggers dose-dependent derepression of a secretion-engineered Aspergillus flavus urate oxidase that eliminates uric acid. Uric Acid 97-106 urate oxidase Mus musculus 201-214
20351688-4 2010 In urate oxidase-deficient mice, which develop acute hyperuricemia, the synthetic circuit decreased blood urate concentration to stable sub-pathologic levels in a dose-dependent manner and reduced uric acid crystal deposits in the kidney. Uric Acid 197-206 urate oxidase Mus musculus 3-16
20380929-5 2010 Patients with PRS-I superactivity primarily present with uric acid overproduction, mental retardation, ataxia, hypotonia, and hearing impairment. Uric Acid 57-66 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 14-19
20450721-12 2010 CONCLUSION: The increase of serum UA levels is associated with LEAD in women, in addition to age, duration of diabetes mellitus, smoking status, systolic blood pressure, body mass index, total cholesterol, triglyceride and C reactive protein. Uric Acid 34-36 C-reactive protein Homo sapiens 223-241
20110790-2 2010 RECENT FINDINGS: Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum uric acid (SUA) levels and the effects were stronger among women (e.g. SUA level difference per copy of a minor allele, -0.46 mg/dl in women vs. -0.22 mg/dl in men). Uric Acid 128-137 solute carrier family 2 member 9 Homo sapiens 82-88
20020821-7 2010 Changes in UA concentrations from admission to day 7 (DeltaUA(day 7)) correlated with the NIHSS score (rho = 0.32; p < 0.001), stroke progression (rho = 0.29; p = 0.001), infarct volume (rho = 0.37; p < 0.001), mRS score (rho = 0.28; p = 0.001) and mortality (p = 0.010). Uric Acid 11-13 sterile alpha motif domain containing 11 Mus musculus 217-220
20110790-2 2010 RECENT FINDINGS: Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum uric acid (SUA) levels and the effects were stronger among women (e.g. SUA level difference per copy of a minor allele, -0.46 mg/dl in women vs. -0.22 mg/dl in men). Uric Acid 128-137 solute carrier family 2 member 9 Homo sapiens 89-94
20110790-5 2010 Functional determination that GLUT9 and ABCG2 can transport urate at the apical border of proximal tubules implicates them as substantial players in the renal excretion of urate. Uric Acid 60-65 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 40-45
20110790-5 2010 Functional determination that GLUT9 and ABCG2 can transport urate at the apical border of proximal tubules implicates them as substantial players in the renal excretion of urate. Uric Acid 172-177 solute carrier family 2 member 9 Homo sapiens 30-35
20110790-3 2010 One study involving four cohorts and one meta-analysis of 14 genome-wide scans found that genetic variants of ABCG2 were associated with higher SUA concentrations and these effects were stronger among men (e.g. uric acid level difference per copy of the minor allele, 0.32 mg/dl in men vs. 0.18 mg/dl in women). Uric Acid 211-220 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 110-115
20110790-5 2010 Functional determination that GLUT9 and ABCG2 can transport urate at the apical border of proximal tubules implicates them as substantial players in the renal excretion of urate. Uric Acid 172-177 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 40-45
20110790-7 2010 SUMMARY: Combined with their activities as urate transporters and their strong associations with serum uric acid concentrations, GLUT9 and ABCG2 appeared to be important modulators of uric acid levels and likely of the risk of gout. Uric Acid 103-112 solute carrier family 2 member 9 Homo sapiens 129-134
20110790-5 2010 Functional determination that GLUT9 and ABCG2 can transport urate at the apical border of proximal tubules implicates them as substantial players in the renal excretion of urate. Uric Acid 60-65 solute carrier family 2 member 9 Homo sapiens 30-35
20110790-7 2010 SUMMARY: Combined with their activities as urate transporters and their strong associations with serum uric acid concentrations, GLUT9 and ABCG2 appeared to be important modulators of uric acid levels and likely of the risk of gout. Uric Acid 184-193 solute carrier family 2 member 9 Homo sapiens 129-134
20199369-9 2010 Direct correlations were found between hepatocyte growth factor levels and ferric reducing activity of plasma as well as hepatocyte growth factor and creatinine or uric acid. Uric Acid 164-173 hepatocyte growth factor Homo sapiens 121-145
20110790-7 2010 SUMMARY: Combined with their activities as urate transporters and their strong associations with serum uric acid concentrations, GLUT9 and ABCG2 appeared to be important modulators of uric acid levels and likely of the risk of gout. Uric Acid 184-193 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 139-144
18945502-0 2010 Uric acid activates extracellular signal-regulated kinases and thereafter endothelin-1 expression in rat cardiac fibroblasts. Uric Acid 0-9 endothelin 1 Rattus norvegicus 74-86
18945502-7 2010 RESULTS: Uric acid-increased cell proliferation and ET-1 gene expression. Uric Acid 9-18 endothelin 1 Rattus norvegicus 52-56
18945502-10 2010 Mutational analysis of the ET-1 gene promoter showed that AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 108-117 endothelin 1 Rattus norvegicus 27-31
18945502-10 2010 Mutational analysis of the ET-1 gene promoter showed that AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 108-117 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 58-62
18945502-8 2010 Uric acid also increased NADPH oxidase activity, ROS formation, ERK phosphorylation, and activator protein-1 (AP-1)-mediated reporter activity. Uric Acid 0-9 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 89-108
18945502-10 2010 Mutational analysis of the ET-1 gene promoter showed that AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 108-117 endothelin 1 Rattus norvegicus 126-130
18945502-11 2010 CONCLUSIONS: These results suggest that uric acid-induced ET-1 gene expression, partially by the activation of ERK pathway via ROS generation in cardiac fibroblasts. Uric Acid 40-49 endothelin 1 Rattus norvegicus 58-62
18945502-8 2010 Uric acid also increased NADPH oxidase activity, ROS formation, ERK phosphorylation, and activator protein-1 (AP-1)-mediated reporter activity. Uric Acid 0-9 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 110-114
18945502-9 2010 Antioxidants suppressed uric acid-induced ET-1 gene expression, and ERK phosphorylation, and AP-1 reporter activities. Uric Acid 24-33 endothelin 1 Rattus norvegicus 42-46
18945502-9 2010 Antioxidants suppressed uric acid-induced ET-1 gene expression, and ERK phosphorylation, and AP-1 reporter activities. Uric Acid 24-33 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 93-97
20133696-5 2010 Moreover, activation of CGD monocytes by uric acid crystals induced a 4-fold higher level of IL-1beta secretion compared with that seen in monocytes from unaffected subjects, and this increase was not due to increased synthesis of the IL-1beta precursor. Uric Acid 41-50 interleukin 1 beta Homo sapiens 93-101
20043336-0 2010 Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile. Uric Acid 36-45 lipoprotein(a) Homo sapiens 71-85
20009031-3 2010 Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. Uric Acid 152-157 solute carrier family 2 member 1 Homo sapiens 9-13
20192932-3 2010 Recent data suggest that clearance of UA is being reduced with increase in insulin resistance and UA as a marker of prediabetes period. Uric Acid 38-40 insulin Homo sapiens 75-82
19765773-9 2010 Cystatin C level was independently associated with HOMA-IR (beta = 0.0380, P = .0082), albumin-creatinine ratio (beta = 0.0004, P < .0001), uric acid (beta = 0.0666, P < .0001), and homocysteine (beta = 0.0087, P = .0004). Uric Acid 143-152 cystatin C Homo sapiens 0-10
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 PDZ domain containing 1 Homo sapiens 112-117
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 glucokinase regulator Homo sapiens 119-123
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 solute carrier family 2 member 9 Homo sapiens 125-131
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 133-138
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 capping protein regulator and myosin 1 linker 1 Homo sapiens 140-147
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 solute carrier family 17 member 1 Homo sapiens 149-156
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 solute carrier family 16 member 9 Homo sapiens 158-165
20162742-3 2010 Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). Uric Acid 6-15 solute carrier family 22 member 12 Homo sapiens 171-179
20162742-5 2010 RESULTS: The most important variables for uric acid prediction with CART were genetic risk score in men and age in women. Uric Acid 42-51 CART prepropeptide Homo sapiens 68-72
20162743-0 2010 Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Uric Acid 73-82 solute carrier family 17 member 3 Homo sapiens 19-26
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 PDZ domain containing 1 Homo sapiens 93-98
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 glucokinase regulator Homo sapiens 100-104
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 solute carrier family 2 member 9 Homo sapiens 106-112
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 114-119
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 capping protein regulator and myosin 1 linker 1 Homo sapiens 121-128
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 solute carrier family 17 member 3 Homo sapiens 130-137
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 solute carrier family 16 member 9 Homo sapiens 139-146
20162743-4 2010 Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. Uric Acid 11-20 solute carrier family 22 member 12 Homo sapiens 152-160
20162743-7 2010 Two SNPs belonging to SLC17A3 gene (rs9393672 and rs942379) yielded significant association with serum uric acid concentration changes in women. Uric Acid 103-112 solute carrier family 17 member 3 Homo sapiens 22-29
20162743-10 2010 Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. Uric Acid 59-68 solute carrier family 17 member 3 Homo sapiens 84-91
20162743-10 2010 Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. Uric Acid 145-154 solute carrier family 17 member 3 Homo sapiens 84-91
20162744-0 2010 Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation. Uric Acid 105-114 solute carrier family 2 member 9 Homo sapiens 41-67
20162744-0 2010 Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation. Uric Acid 105-114 solute carrier family 2 member 9 Homo sapiens 69-75
20162744-1 2010 AIM: To investigate possible interactions between genetic variants in glucose transporter type 9 (SLC2A9) gene and dietary habits in serum uric acid regulation. Uric Acid 139-148 solute carrier family 2 member 9 Homo sapiens 70-96
20162744-1 2010 AIM: To investigate possible interactions between genetic variants in glucose transporter type 9 (SLC2A9) gene and dietary habits in serum uric acid regulation. Uric Acid 139-148 solute carrier family 2 member 9 Homo sapiens 98-104
20162744-3 2010 Three single nucleotide polymorphisms (SNP) from the SLC2A9 gene (rs1014290, rs6449213, rs737267) were correlated with dietary habits and uric acid. Uric Acid 138-147 solute carrier family 2 member 9 Homo sapiens 53-59
20162744-8 2010 CONCLUSION: There is a certain extent of interaction between SLC2A9 and dietary patterns in serum uric acid determination. Uric Acid 98-107 solute carrier family 2 member 9 Homo sapiens 61-67
20162745-8 2010 Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis. Uric Acid 80-89 solute carrier family 2 member 9 Homo sapiens 50-56
20352728-1 2010 A uric acid biosensor has been fabricated through the immobilization of uricase on glassy carbon electrode modified by biomimetic titanate nanotubes of high specific surface area synthesized by hydrothermal decomposition. Uric Acid 2-11 urate oxidase (pseudogene) Homo sapiens 72-79
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 100-134
20140863-6 2010 CONCLUSION: The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population. Uric Acid 239-248 regulator of G protein signaling 2 Homo sapiens 101-105
20006114-0 2010 Cu nanoparticles incorporated polypyrrole modified GCE for sensitive simultaneous determination of dopamine and uric acid. Uric Acid 112-121 aminomethyltransferase Homo sapiens 51-54
20149224-0 2010 High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals. Uric Acid 107-112 C-C motif chemokine ligand 2 Homo sapiens 39-43
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 94-98
20023662-4 2010 Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. Uric Acid 32-41 thioredoxin interacting protein Mus musculus 79-84
20023662-4 2010 Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. Uric Acid 32-41 thioredoxin 1 Mus musculus 90-101
20023662-4 2010 Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. Uric Acid 32-41 NLR family, pyrin domain containing 3 Mus musculus 177-182
19915948-1 2010 Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a key enzyme in purine degradation where it oxidizes hypoxanthine to xanthine and xanthine to uric acid. Uric Acid 153-162 xanthine dehydrogenase 1 Arabidopsis thaliana 23-29
19861489-8 2010 We also observed the GCKR locus to be associated with total cholesterol (P = 7.52 x 10(-6)), triglycerides (P = 2.65 x 10(-9)), fasting glucose (P = 0.011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. Uric Acid 168-170 glucokinase regulator Homo sapiens 21-25
19861489-8 2010 We also observed the GCKR locus to be associated with total cholesterol (P = 7.52 x 10(-6)), triglycerides (P = 2.65 x 10(-9)), fasting glucose (P = 0.011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. Uric Acid 275-277 glucokinase regulator Homo sapiens 21-25
19861489-9 2010 We argue that GCKR locus affects serum UA levels through a factor that also affects triglycerides. Uric Acid 39-41 glucokinase regulator Homo sapiens 14-18
20486468-5 2010 These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serum urate lowering agents. Uric Acid 175-180 solute carrier family 22 member 12 Homo sapiens 66-71
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 100-134
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 136-141
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 94-98
20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 136-141
21469322-0 2010 [Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes]. Uric Acid 19-28 insulin Homo sapiens 53-60
20048433-4 2010 They decrease the production of uric acid precursor in skeletal muscles under anaerobic condition induced by hypertension or insulin resistance. Uric Acid 32-41 insulin Homo sapiens 125-132
22747073-4 2010 In vitro and in vivo pharmacodynamic studies on the hyperuricemia rat model explicitly suggested that the uricase entrapped by UOXLVs possessed high uricolytic activity and distinctively decreased the uric acid level. Uric Acid 201-210 urate oxidase Rattus norvegicus 106-113
20190416-0 2010 Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Uric Acid 19-28 solute carrier family 22 member 7 Homo sapiens 32-59
20190416-0 2010 Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Uric Acid 19-28 solute carrier family 22 member 7 Homo sapiens 61-65
20190416-0 2010 Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Uric Acid 19-28 solute carrier family 22 member 7 Homo sapiens 66-73
20190416-1 2010 The physiological function of organic anion transporter OAT2 (SLC22A7) remains unclear, but since OAT2 transports purine derivatives, it may be involved in renal handling of uric acid, the final metabolite of purine derivatives. Uric Acid 174-183 solute carrier family 22 member 7 Homo sapiens 56-60
20190416-1 2010 The physiological function of organic anion transporter OAT2 (SLC22A7) remains unclear, but since OAT2 transports purine derivatives, it may be involved in renal handling of uric acid, the final metabolite of purine derivatives. Uric Acid 174-183 solute carrier family 22 member 7 Homo sapiens 62-69
20190416-1 2010 The physiological function of organic anion transporter OAT2 (SLC22A7) remains unclear, but since OAT2 transports purine derivatives, it may be involved in renal handling of uric acid, the final metabolite of purine derivatives. Uric Acid 174-183 solute carrier family 22 member 7 Homo sapiens 98-102
20190416-2 2010 In the present study, we studied uric acid transport in stably OAT2-expressing HEK293 cells (HEK293/OAT2). Uric Acid 33-42 solute carrier family 22 member 7 Homo sapiens 63-67
20190416-3 2010 OAT2 mediated uptake, but not efflux, of [(14)C]uric acid. Uric Acid 48-57 solute carrier family 22 member 7 Homo sapiens 0-4
20190416-8 2010 The pattern of inhibition of OAT2-mediated uric acid transport by various drugs was different from that of OAT1- or OAT3-mediated transport. Uric Acid 43-52 solute carrier family 22 member 7 Homo sapiens 29-33
20190416-9 2010 Furthermore, OAT2-mediated transport of uric acid was inhibited by an antiuricosuric drug, pyrazinecarboxylic acid. Uric Acid 40-49 solute carrier family 22 member 7 Homo sapiens 13-17
20190416-10 2010 These results revealed distinct characteristics of uric acid transport via OAT2 compared with other uric acid transporters, suggesting that OAT2 plays a role in renal uric acid uptake from blood as a first step of tubular secretion. Uric Acid 51-60 solute carrier family 22 member 7 Homo sapiens 75-79
20190416-10 2010 These results revealed distinct characteristics of uric acid transport via OAT2 compared with other uric acid transporters, suggesting that OAT2 plays a role in renal uric acid uptake from blood as a first step of tubular secretion. Uric Acid 51-60 solute carrier family 22 member 7 Homo sapiens 140-144
20190416-10 2010 These results revealed distinct characteristics of uric acid transport via OAT2 compared with other uric acid transporters, suggesting that OAT2 plays a role in renal uric acid uptake from blood as a first step of tubular secretion. Uric Acid 100-109 solute carrier family 22 member 7 Homo sapiens 140-144
20190416-11 2010 OAT2 may therefore be a potential target for regulating serum uric acid level. Uric Acid 62-71 solute carrier family 22 member 7 Homo sapiens 0-4
19819286-6 2010 In vitro, 6-shogaol reduced the level of beta-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated polymorphonuclear leucocytes in concentration dependent manner when compared to control cells. Uric Acid 89-105 glucuronidase, beta Mus musculus 41-59
21469322-8 2010 The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome. Uric Acid 102-104 insulin Homo sapiens 50-57
23960588-16 2010 Therefore, higher serum uric acid levels are associated with increased C-IMT and left ventricular hypertrophy in hypertensive and even non hypertensive patients. Uric Acid 24-33 CIMT Homo sapiens 71-76
21694941-9 2010 These include febuxostat, a nonpurine inhibitor of xanthine oxidase with a potentially better combination of efficacy and safety than allopurinol, and investigational inhibitors of URAT-1, an anion exchanger in the proximal tubule that is critical for uric acid homeostasis. Uric Acid 252-261 solute carrier family 22 member 12 Homo sapiens 181-187
20075570-6 2010 CONCLUSION: Fenofibrate decreased serum uric acid levels by increasing its urinary excretion, most likely through the inhibition of URAT1 by fenofibric acid, its major metabolite. Uric Acid 40-49 solute carrier family 22 member 12 Homo sapiens 132-137
19926891-9 2010 In conclusion, homozygous loss-of-function mutations of GLUT9 cause a total defect of uric acid absorption, leading to severe renal hypouricemia complicated by nephrolithiasis and exercise-induced acute renal failure. Uric Acid 86-95 solute carrier family 2 member 9 Homo sapiens 56-61
20051757-6 2010 The temporal associations of this attack with the initiation of ART and the observed immunologic reconstitution make IRIS a clinical possibility.Monosodium urate crystals through their interactions with interleukin 1- beta, and neutrophilic synovitis play a critical role in the pathophysiology of gout. Uric Acid 145-161 interleukin 1 beta Homo sapiens 203-222
21208527-6 2010 UA increment was lower than ARE but long-lasting and correlated with FRAP. Uric Acid 0-2 mechanistic target of rapamycin kinase Homo sapiens 69-73
20560471-6 2010 In URAT1-stably expressing HEK293 (HEK293-URAT1) cells, salicylate inhibited [14C] urate uptake dose-dependently (IC50, 23.9 microM). Uric Acid 83-88 solute carrier family 22 member 12 Homo sapiens 3-8
20560471-8 2010 [3H] Salicylate uptake via URAT1 was inhibited by non-labelled urate and salicylate, and the uricosuric agent, benzbromarone. Uric Acid 63-68 solute carrier family 22 member 12 Homo sapiens 27-32
20560471-11 2010 These results suggest that the "paradoxical effect" of salicylate can be explained by two modes of salicylate interaction with URAT1 : (1) acting as an exchange substrate to facilitate urate reabsorption, and (2) acting as an inhibitor for urate reabsorption. Uric Acid 185-190 solute carrier family 22 member 12 Homo sapiens 127-132
20560471-11 2010 These results suggest that the "paradoxical effect" of salicylate can be explained by two modes of salicylate interaction with URAT1 : (1) acting as an exchange substrate to facilitate urate reabsorption, and (2) acting as an inhibitor for urate reabsorption. Uric Acid 240-245 solute carrier family 22 member 12 Homo sapiens 127-132
20697570-3 2010 Humans lack the ability to synthesize vitamin C due to a mutation in L-gulono-lactone oxidase that occurred during the late Eocene, and humans have higher serum uric acid levels due to a mutation in uricase that occurred in the mid Miocene. Uric Acid 161-170 urate oxidase (pseudogene) Homo sapiens 199-206
20199182-2 2010 In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis. Uric Acid 201-210 insulin Homo sapiens 66-73
19733474-1 2009 Single-walled carbon nanohorn modified glassy carbon electrode (SWCNH-modified GCE) was first employed for the simultaneous determination of uric acid (UA), dopamine (DA), and ascorbic acid (AA). Uric Acid 141-150 aminomethyltransferase Homo sapiens 79-82
20090896-4 2009 URAT1 was the first transporter affecting serum urate concentrations to be identified. Uric Acid 48-53 solute carrier family 22 member 12 Homo sapiens 0-5
20090896-7 2009 Recent genome-wide association studies have led to validation of the in vitro model constructed from each functional analysis of urate transporters, and identification of novel candidate genes related to urate metabolism and transport proteins, such as glucokinase regulatory protein (GKRP), PDZK1 and MCT9. Uric Acid 129-134 glucokinase regulator Homo sapiens 253-283
20090896-7 2009 Recent genome-wide association studies have led to validation of the in vitro model constructed from each functional analysis of urate transporters, and identification of novel candidate genes related to urate metabolism and transport proteins, such as glucokinase regulatory protein (GKRP), PDZK1 and MCT9. Uric Acid 129-134 glucokinase regulator Homo sapiens 285-289
19733474-1 2009 Single-walled carbon nanohorn modified glassy carbon electrode (SWCNH-modified GCE) was first employed for the simultaneous determination of uric acid (UA), dopamine (DA), and ascorbic acid (AA). Uric Acid 152-154 aminomethyltransferase Homo sapiens 79-82
19729142-0 2009 Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. Uric Acid 0-9 insulin Homo sapiens 45-52
20007584-6 2009 Finally, IL-1beta production and inflammation are reduced in mice deficient for the NALP3 inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and we identified uric acid, which is produced upon elastase-induced lung injury, as an activator of the NALP3/ASC inflammasome. Uric Acid 218-227 interleukin 1 beta Mus musculus 9-17
20007584-6 2009 Finally, IL-1beta production and inflammation are reduced in mice deficient for the NALP3 inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and we identified uric acid, which is produced upon elastase-induced lung injury, as an activator of the NALP3/ASC inflammasome. Uric Acid 218-227 NLR family, pyrin domain containing 3 Mus musculus 84-89
19729142-1 2009 OBJECTIVE: We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth. Uric Acid 44-53 insulin Homo sapiens 106-113
19729142-3 2009 The association between uric acid and insulin resistance, as estimated using the homeostasis model assessment (HOMA), was analyzed and related to birthweights. Uric Acid 24-33 insulin Homo sapiens 38-45
19729142-6 2009 CONCLUSION: Increasing uric acid concentrations were associated with insulin resistance in midpregnancy. Uric Acid 23-32 insulin Homo sapiens 69-76
19850541-9 2009 Serum adiponectin concentration was inversely correlated with age, HOMA, ALT and uric acid and directly correlated with HDL-cholesterol. Uric Acid 81-90 adiponectin, C1Q and collagen domain containing Homo sapiens 6-17
20368174-2 2009 The ABCG2/BCRP gene, located in a gout-susceptibility locus on chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Uric Acid 149-158 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 4-9
19709697-4 2009 The aim of this study was to explore the association between RBP4 level and metabolic parameters especially uric acid in patients with type 2 diabetes mellitus. Uric Acid 108-117 retinol binding protein 4 Homo sapiens 61-65
19709697-7 2009 Pearson correlations revealed that serum RBP4 level correlated positively with age, waist circumference, waist-to-hip ratio, systolic blood pressure, total cholesterol, triglyceride, uric acid, creatinine, and urine albumin-to-creatinine ratio. Uric Acid 183-192 retinol binding protein 4 Homo sapiens 41-45
19709697-10 2009 In conclusion, RBP4 level was independently associated with uric acid level. Uric Acid 60-69 retinol binding protein 4 Homo sapiens 15-19
20368174-2 2009 The ABCG2/BCRP gene, located in a gout-susceptibility locus on chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Uric Acid 149-158 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 10-14
20368174-3 2009 Urate transport assays demonstrated that ABCG2 is a high-capacity urate secretion transporter. Uric Acid 0-5 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 41-46
20368174-5 2009 Quantitative trait locus analysis of 739 individuals showed that a common dysfunctional variant of ABCG2, Q141K, increases serum uric acid. Uric Acid 129-138 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 99-104
19903375-5 2009 The concentration of uric acid was determined by the method of urate oxidase and peroxide enzyme. Uric Acid 21-30 urate oxidase Mus musculus 63-76
19636222-8 2009 Furthermore, urate inhibited the activation of JAK2, STAT1, and STAT3. Uric Acid 13-18 Janus kinase 2 Rattus norvegicus 47-51
19636222-8 2009 Furthermore, urate inhibited the activation of JAK2, STAT1, and STAT3. Uric Acid 13-18 signal transducer and activator of transcription 1 Rattus norvegicus 53-58
19636222-8 2009 Furthermore, urate inhibited the activation of JAK2, STAT1, and STAT3. Uric Acid 13-18 signal transducer and activator of transcription 3 Rattus norvegicus 64-69
19636222-9 2009 Finally, homogenates from renal cortices demonstrated reduced expression of TGF- beta1 and fibronectin under urate treatment. Uric Acid 109-114 transforming growth factor, beta 1 Rattus norvegicus 76-86
19636222-9 2009 Finally, homogenates from renal cortices demonstrated reduced expression of TGF- beta1 and fibronectin under urate treatment. Uric Acid 109-114 fibronectin 1 Rattus norvegicus 91-102
19845893-7 2009 Higher TNF-alpha and sTNFR1 concentrations were also associated with the presence of heart failure (HF), lower ejection and shortening fraction, the presence of diabetes or metabolic syndrome, lower serum HDL cholesterol, and higher uric acid. Uric Acid 233-242 tumor necrosis factor Homo sapiens 7-16
19847307-7 2009 Both LRRK2 and idiopathic PD patients showed significantly reduced uric acid levels. Uric Acid 67-76 leucine rich repeat kinase 2 Homo sapiens 5-10
19808794-2 2009 Hyperuricaemia is the primary risk factor for the development of gout and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase gene. Uric Acid 118-127 urate oxidase (pseudogene) Homo sapiens 161-168
19783673-0 2009 Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. Uric Acid 90-99 NLR family, pyrin domain containing 3 Mus musculus 56-61
19783673-10 2009 These data suggest that uric acid is released during malaria infection and may serve to augment the initial host response to hemozoin via activation of the NALP3 inflammasome. Uric Acid 24-33 NLR family, pyrin domain containing 3 Mus musculus 156-161
19528034-1 2009 BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout. Uric Acid 12-28 interleukin 1 beta Mus musculus 94-112
19797240-5 2009 Several recent large-scale human genetic studies show a correlation between SNPs mapped to GLUT9 and the serum uric acid levels in several different cohorts. Uric Acid 111-120 solute carrier family 2 member 9 Homo sapiens 91-96
19797240-6 2009 The relationship between GLUT9 and uric acid is highly clinically significant. Uric Acid 35-44 solute carrier family 2 member 9 Homo sapiens 25-30
19797240-9 2009 It is also known that GLUT9 is expressed in articular cartilage and is a uric acid transporter, and thus it is possible that GLUT9 plays a role in gout, a disease of uric acid deposition in the joints. Uric Acid 73-82 solute carrier family 2 member 9 Homo sapiens 22-27
19797240-9 2009 It is also known that GLUT9 is expressed in articular cartilage and is a uric acid transporter, and thus it is possible that GLUT9 plays a role in gout, a disease of uric acid deposition in the joints. Uric Acid 73-82 solute carrier family 2 member 9 Homo sapiens 125-130
19528034-1 2009 BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout. Uric Acid 12-28 interleukin 1 beta Mus musculus 114-121
19528034-1 2009 BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout. Uric Acid 30-33 interleukin 1 beta Mus musculus 114-121
19706426-0 2009 Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Uric Acid 30-35 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-5
19667249-10 2009 These results suggest that XOR gene disruption induced the depletion of uric acid and the accumulation of triglyceride-rich substances, xanthine, and hypoxanthine in the renal tubules. Uric Acid 72-81 xanthine dehydrogenase Mus musculus 27-30
19725880-6 2009 All transthyretin-like proteins studied to date have been demonstrated to function in purine metabolism by hydrolysing the oxidative product of uric acid, 5-hydroxyisourate. Uric Acid 144-153 transthyretin Homo sapiens 4-17
19706426-4 2009 Here, we investigated the role of the recently identified urate transporter, Glut9, in the physiological control of urate homeostasis using mice with systemic or liver-specific inactivation of the Glut9 gene. Uric Acid 58-63 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 77-82
19706426-8 2009 Together, our data show that Glut9 plays a major role in urate homeostasis by its dual role in urate handling in the kidney and uptake in the liver. Uric Acid 57-62 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 29-34
19706426-8 2009 Together, our data show that Glut9 plays a major role in urate homeostasis by its dual role in urate handling in the kidney and uptake in the liver. Uric Acid 95-100 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 29-34
19593129-1 2009 PURPOSE OF REVIEW: The goal of this article is to review the possible physiological roles of the recently identified urate transporter, solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9), in the renal handling of urate. Uric Acid 117-122 solute carrier family 2 member 9 Homo sapiens 136-203
19587147-7 2009 The well-known uricosuric agents benzbromarone (500 microM) and losartan (1 mM) inhibit GLUT9-mediated urate uptake by 90 and 50%, respectively. Uric Acid 103-108 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 88-93
19587147-9 2009 Electrophysiological measurements suggest that urate transport by mouse GLUT9 is electrogenic and voltage dependent, but independent of the Na(+) and Cl(-) transmembrane gradients. Uric Acid 47-52 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 72-77
19587147-10 2009 Taken together, our results suggest that GLUT9 works as a urate (anion) uniporter. Uric Acid 58-63 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 41-46
19587147-12 2009 Expression of mouse GLUT9 in the kidney differs from that of human GLUT9, which could account for species differences in urate handling. Uric Acid 121-126 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 20-25
19587147-12 2009 Expression of mouse GLUT9 in the kidney differs from that of human GLUT9, which could account for species differences in urate handling. Uric Acid 121-126 solute carrier family 2 member 9 Homo sapiens 67-72
19557736-1 2009 BACKGROUND: Elevated serum uric acid has been related to insulin resistance, but there are no studies regarding its association with beta-cell function. Uric Acid 27-36 insulin Homo sapiens 57-64
19593129-1 2009 PURPOSE OF REVIEW: The goal of this article is to review the possible physiological roles of the recently identified urate transporter, solute carrier family 2 (facilitated glucose transporter), member 9 (SLC2A9), in the renal handling of urate. Uric Acid 117-122 solute carrier family 2 member 9 Homo sapiens 205-211
19593129-7 2009 Expression of SLC2A9a and b in Xenopus laevis oocytes shows that these proteins mediate rapid urate fluxes and can exchange glucose for urate. Uric Acid 94-99 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 14-21
19593129-7 2009 Expression of SLC2A9a and b in Xenopus laevis oocytes shows that these proteins mediate rapid urate fluxes and can exchange glucose for urate. Uric Acid 136-141 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 14-21
19593129-9 2009 SUMMARY: This review proposes that SLC2A9 contributes significantly in two ways to the fluxes of urate across the proximal convoluted tubule. Uric Acid 97-102 solute carrier family 2 member 9 Homo sapiens 35-41
19593129-11 2009 Secondly, the basolateral membrane SLC2A9a could be the primary route for urate movement out of the epithelium into the peritubular space. Uric Acid 74-79 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 35-42
19893872-8 2009 In multiple regression analysis, BMI, HDL-cholesterol and adiponectin were independent predictors of plasma uric acid. Uric Acid 108-117 adiponectin, C1Q and collagen domain containing Homo sapiens 58-69
19458127-2 2009 We tested the hypothesis that lowering uric acid with a xanthine oxidase inhibitor might reduce renal injury in the diabetic mouse. Uric Acid 39-48 xanthine dehydrogenase Mus musculus 56-72
19893872-1 2009 Elevated plasma uric acid levels are associated with obesity and could be an expression of insulin-resistant state. Uric Acid 16-25 insulin Homo sapiens 91-98
19776696-5 2009 RESULTS: Subjects with a PSA level of 11-20 ng/ml and PSA >20 ng/ml had significantly lower uric acid and reduced glutathione levels (p <0.05). Uric Acid 95-104 kallikrein related peptidase 3 Homo sapiens 25-28
19776696-5 2009 RESULTS: Subjects with a PSA level of 11-20 ng/ml and PSA >20 ng/ml had significantly lower uric acid and reduced glutathione levels (p <0.05). Uric Acid 95-104 kallikrein related peptidase 3 Homo sapiens 54-57
19458127-10 2009 An inflammatory role of uric acid on tubular cells was also confirmed by our in vitro evidence that uric acid directly induced ICAM-1 expression in the human proximal tubular cell. Uric Acid 24-33 intercellular adhesion molecule 1 Homo sapiens 127-133
19458127-10 2009 An inflammatory role of uric acid on tubular cells was also confirmed by our in vitro evidence that uric acid directly induced ICAM-1 expression in the human proximal tubular cell. Uric Acid 100-109 intercellular adhesion molecule 1 Homo sapiens 127-133
19544009-4 2009 We report an unusual mutation in the MOCS1 gene associated with a relatively mild clinical phenotype, in a patient who presented with normal uric acid (UA) levels in plasma. Uric Acid 141-150 molybdenum cofactor synthesis 1 Homo sapiens 37-42
19667479-3 2009 The hydrogen peroxide produced from the catalytic oxidation of uric acid by uricase was reduced electrocatalytically by immobilized hemoglobin and used to obtain a sensitive amperometric response to uric acid. Uric Acid 63-72 urate oxidase (pseudogene) Homo sapiens 76-83
19667479-3 2009 The hydrogen peroxide produced from the catalytic oxidation of uric acid by uricase was reduced electrocatalytically by immobilized hemoglobin and used to obtain a sensitive amperometric response to uric acid. Uric Acid 199-208 urate oxidase (pseudogene) Homo sapiens 76-83
19640330-4 2009 RESULTS: The best model (R2=0.989) for predicting adiponectin in type 1 diabetes included fibrinogen, white blood cell count, uric acid and triglycerides. Uric Acid 126-135 adiponectin, C1Q and collagen domain containing Homo sapiens 50-61
19544009-4 2009 We report an unusual mutation in the MOCS1 gene associated with a relatively mild clinical phenotype, in a patient who presented with normal uric acid (UA) levels in plasma. Uric Acid 152-154 molybdenum cofactor synthesis 1 Homo sapiens 37-42
19721344-6 2009 Indeed, monosodium urate monohydrate (MSU) crystals induced TREM-1 expression in vitro and in vivo. Uric Acid 8-36 triggering receptor expressed on myeloid cells 1 Mus musculus 60-66
19258383-1 2009 BACKGROUND: Uric acid is heritable and associated with hypertension and insulin resistance. Uric Acid 12-21 insulin Homo sapiens 72-79
19258383-11 2009 Bivariate linkage analyses and pathway analysis were consistent with genes regulating insulin resistance and fructose metabolism contributing to the heritability of uric acid. Uric Acid 165-174 insulin Homo sapiens 86-93
19721344-6 2009 Indeed, monosodium urate monohydrate (MSU) crystals induced TREM-1 expression in vitro and in vivo. Uric Acid 38-41 triggering receptor expressed on myeloid cells 1 Mus musculus 60-66
19565499-1 2009 A deficiency in hypoxanthine guanine phosphoribosyltransferase (HPRT) activity leads to overproduction of uric acid. Uric Acid 106-115 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 64-68
19576345-5 2009 Primary end-point rates were directly related to increasing tertiles (from tertile 1 [T1] to tertile 3 [T3]) of UA (12.7%, 12.8%, and 17.6% respectively, p for trend <0.0001) and CRP (11.5%, 14.2%, and 17.3% respectively, p for trend <0.002). Uric Acid 112-114 C-reactive protein Homo sapiens 182-185
18572267-7 2009 Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p<0.02). Uric Acid 106-115 alkaline phosphatase, placental Homo sapiens 6-9
19295502-4 2009 In the absence of stage 3 or 4 CKD, patients with elevated serum cystatin C had a higher prevalence of low hemoglobin and elevated uric acid, homocysteine, phosphorus, fibrinogen, and C-reactive protein than patients with a normal serum cystatin C. Uric Acid 131-140 cystatin C Homo sapiens 65-75
19506252-4 2009 We further show that native ABCG2 is located in the brush border membrane of kidney proximal tubule cells, where it mediates renal urate secretion. Uric Acid 131-136 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 28-33
19425822-7 2009 In a patient with low serum UA and high lesion activity, raising UA levels by inosine treatment decreased serum nitrotyrosine while increasing the ratio of Th2 to Th1 cytokines in circulating cells. Uric Acid 65-67 negative elongation factor complex member C/D Homo sapiens 163-166
19319672-1 2009 The activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) is virtually absent in Lesch-Nyhan disease (LND), an X-linked genetic disorder characterized by uric acid accumulation and neurodevelopmental dysfunction. Uric Acid 166-175 hypoxanthine guanine phosphoribosyl transferase Mus musculus 16-62
19319672-1 2009 The activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) is virtually absent in Lesch-Nyhan disease (LND), an X-linked genetic disorder characterized by uric acid accumulation and neurodevelopmental dysfunction. Uric Acid 166-175 hypoxanthine guanine phosphoribosyl transferase Mus musculus 64-68
19439372-5 2009 Aluminum adjuvants activate NLRP3 by multiple mechanisms such as by causing damage and rupture of the phagolysosomes, generating reactive oxygen species, inducing K(+) efflux and via release from injured tissues of molecules that constitute danger-associated molecular patterns (DAMPs) such as uric acid and ATP. Uric Acid 294-303 NLR family pyrin domain containing 3 Homo sapiens 28-33
19503597-5 2009 We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women. Uric Acid 88-97 solute carrier family 2 member 9 Homo sapiens 47-53
19503597-5 2009 We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women. Uric Acid 166-175 solute carrier family 2 member 9 Homo sapiens 47-53
19503597-5 2009 We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women. Uric Acid 166-175 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 151-156
19545696-7 2009 By Pearson"s correlation coefficient, UA was inversely correlated with estimated glomerular filtration rate (eGFR; R = -.39; P < .0001) and directly correlated with C-reactive protein (CRP; R = .10; P = .02). Uric Acid 38-40 C-reactive protein Homo sapiens 168-186
19545696-7 2009 By Pearson"s correlation coefficient, UA was inversely correlated with estimated glomerular filtration rate (eGFR; R = -.39; P < .0001) and directly correlated with C-reactive protein (CRP; R = .10; P = .02). Uric Acid 38-40 C-reactive protein Homo sapiens 188-191
19218193-3 2009 OBJECTIVES: To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating the NALP3 inflammasome in the lung. Uric Acid 146-155 NLR family, pyrin domain containing 3 Mus musculus 180-185
19218193-6 2009 MEASUREMENTS AND MAIN RESULTS: Lung injury depends on the NALP3 inflammasome, which is triggered by uric acid locally produced in the lung upon BLM-induced DNA damage and degradation. Uric Acid 100-109 NLR family, pyrin domain containing 3 Mus musculus 58-63
19218193-0 2009 Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Uric Acid 0-9 NLR family, pyrin domain containing 3 Mus musculus 40-45
19218193-7 2009 Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis. Uric Acid 13-22 urate oxidase Mus musculus 88-95
19218193-7 2009 Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis. Uric Acid 13-22 interleukin 1 beta Mus musculus 131-139
19218193-7 2009 Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis. Uric Acid 53-62 interleukin 1 beta Mus musculus 131-139
19218193-8 2009 Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor. Uric Acid 34-43 NLR family, pyrin domain containing 3 Mus musculus 117-122
19218193-8 2009 Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor. Uric Acid 34-43 myeloid differentiation primary response gene 88 Mus musculus 137-142
19218193-8 2009 Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor. Uric Acid 34-43 interleukin 1 receptor, type I Mus musculus 148-154
19218193-8 2009 Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor. Uric Acid 34-43 toll-like receptor 2 Mus musculus 188-193
19218193-8 2009 Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor. Uric Acid 34-43 toll-like receptor 4 Mus musculus 198-202
19218193-9 2009 CONCLUSIONS: Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production. Uric Acid 13-22 NLR family, pyrin domain containing 3 Mus musculus 115-120
19218193-9 2009 CONCLUSIONS: Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production. Uric Acid 13-22 interleukin 1 beta Mus musculus 146-154
19218193-10 2009 Reducing uric acid tissue levels represents a novel therapeutic approach to control IL-1beta production and chronic inflammatory lung pathology. Uric Acid 9-18 interleukin 1 beta Mus musculus 84-92
19302482-8 2009 Of interest, the stimulation of L-type Ca(2+) channels by high K(+)-induced depolarization and the ensuing activation of extracellular signal-regulated kinases 1/2 strongly improved the neuroprotective effect of UA whereas the depolarizing signal alone had no effect. Uric Acid 212-214 mitogen-activated protein kinase 3 Homo sapiens 121-163
19584965-1 2009 Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans. Uric Acid 92-101 xanthine dehydrogenase Homo sapiens 56-59
19584965-1 2009 Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O2(-)), in humans. Uric Acid 103-105 xanthine dehydrogenase Homo sapiens 56-59
19534022-8 2009 In both groups, higher uric acid levels translated into an increase in metabolic syndrome components, in markers of insulin resistance, triglyceride / high-density lipoprotein levels, and Apo B/Apo A-I ratios, as well as in Framingham scores. Uric Acid 23-32 insulin Homo sapiens 116-123
19534022-8 2009 In both groups, higher uric acid levels translated into an increase in metabolic syndrome components, in markers of insulin resistance, triglyceride / high-density lipoprotein levels, and Apo B/Apo A-I ratios, as well as in Framingham scores. Uric Acid 23-32 apolipoprotein B Homo sapiens 188-193
19534022-8 2009 In both groups, higher uric acid levels translated into an increase in metabolic syndrome components, in markers of insulin resistance, triglyceride / high-density lipoprotein levels, and Apo B/Apo A-I ratios, as well as in Framingham scores. Uric Acid 23-32 apolipoprotein A1 Homo sapiens 194-201
19189137-9 2009 A non-URAT1 genetic defect that causes decreased reabsorption or, more probably, increased secretion of uric acid, induces IRHU. Uric Acid 104-113 solute carrier family 22 member 12 Homo sapiens 6-11
19195936-4 2009 The electrocatalytic currents increases linearly with the DA and UA concentrations in the ranges of 0.1-900 microM and 20-650 microM, and the detection limits for DA and UA, were 0.087 and 15 muM, respectively. Uric Acid 65-67 latexin Homo sapiens 192-195
19290667-4 2009 On the basis of these results, the cyt c-TiO(2) nanocomposits film is capable of sensing H(2)O(2) at a suitable potential, 0.0 V (vs Ag AgCl), where not only common anodic interferences like ascorbic acid, uric acid, 3,4-dihydroxyphenylacetic acid but also a cathodic interference, O(2), are effectively avoided. Uric Acid 206-215 cytochrome c, somatic Homo sapiens 35-40
19439211-8 2009 Serum uric acid also correlated with indices of hepatocellular health (GGT, ALT, AST). Uric Acid 6-15 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 71-74
19439211-8 2009 Serum uric acid also correlated with indices of hepatocellular health (GGT, ALT, AST). Uric Acid 6-15 solute carrier family 17 member 5 Homo sapiens 81-84
20664715-8 2009 Urate, a peroxynitrite scavenger, inhibited the effects of SIN-1 on phosphatase activity and the interaction of PLB with PP2a, thus implicating peroxynitrite as the causal species. Uric Acid 0-5 MAPK associated protein 1 Homo sapiens 59-64
20664715-8 2009 Urate, a peroxynitrite scavenger, inhibited the effects of SIN-1 on phosphatase activity and the interaction of PLB with PP2a, thus implicating peroxynitrite as the causal species. Uric Acid 0-5 phospholamban Homo sapiens 112-115
20664715-8 2009 Urate, a peroxynitrite scavenger, inhibited the effects of SIN-1 on phosphatase activity and the interaction of PLB with PP2a, thus implicating peroxynitrite as the causal species. Uric Acid 0-5 protein phosphatase 2 phosphatase activator Homo sapiens 121-125
19476113-10 2009 Uric acid levels were higher in patients with CSX or CAD than in the control subjects (5.5 +/- 1.1 mg/dl and 5.9 +/- 1.4 mg/dl, respectively, vs. 4.4 +/- 1.2 mg/dl; P < 0.00 1), but those levels were also similar in patients with CSX or CAD. Uric Acid 0-9 NK2 homeobox 5 Homo sapiens 46-49
19476113-10 2009 Uric acid levels were higher in patients with CSX or CAD than in the control subjects (5.5 +/- 1.1 mg/dl and 5.9 +/- 1.4 mg/dl, respectively, vs. 4.4 +/- 1.2 mg/dl; P < 0.00 1), but those levels were also similar in patients with CSX or CAD. Uric Acid 0-9 NK2 homeobox 5 Homo sapiens 233-236
19476113-11 2009 CONCLUSIONS: In patients with CSX, serum CRP and UA levels were as high as those in patients with CAD. Uric Acid 49-51 NK2 homeobox 5 Homo sapiens 30-33
19195936-4 2009 The electrocatalytic currents increases linearly with the DA and UA concentrations in the ranges of 0.1-900 microM and 20-650 microM, and the detection limits for DA and UA, were 0.087 and 15 muM, respectively. Uric Acid 170-172 latexin Homo sapiens 192-195
19225200-2 2009 Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. Uric Acid 0-9 renin Homo sapiens 127-132
19105055-10 2009 CONCLUSION: Our results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women. Uric Acid 174-179 insulin Homo sapiens 55-62
19225200-2 2009 Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. Uric Acid 11-13 renin Homo sapiens 127-132
19552891-8 2009 Varp has been shown to regulate endosome dynamics, suggesting that BmVarp may play an important role in the incorporation and/or accumulation of uric acid in the epidermis. Uric Acid 145-154 putative VPS9-ankyrin repeat-containing protein Bombyx mori 0-4
19224237-8 2009 Urate oxidase, a cuproprotein catalyzing the oxidation of urate to allantoin, is confined to the peroxisomal core, yet is lacking in human PO. Uric Acid 58-63 urate oxidase Rattus norvegicus 0-13
19552891-8 2009 Varp has been shown to regulate endosome dynamics, suggesting that BmVarp may play an important role in the incorporation and/or accumulation of uric acid in the epidermis. Uric Acid 145-154 putative VPS9-ankyrin repeat-containing protein Bombyx mori 67-73
19388706-1 2009 Xanthine oxidoreductase (XOR) is a molybdenum-containing enzyme that under physiological conditions catalyzes the final two steps in purine catabolism, ultimately generating uric acid for excretion. Uric Acid 174-183 xanthine dehydrogenase Bos taurus 0-23
19388706-1 2009 Xanthine oxidoreductase (XOR) is a molybdenum-containing enzyme that under physiological conditions catalyzes the final two steps in purine catabolism, ultimately generating uric acid for excretion. Uric Acid 174-183 xanthine dehydrogenase Bos taurus 25-28
19580188-13 2009 Elevated uric acid serum level may be a marker of elevated pulse pressure in children with IgAN and SHN. Uric Acid 9-18 IGAN1 Homo sapiens 91-95
19444535-0 2009 Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study. Uric Acid 74-83 matrix metallopeptidase 9 Homo sapiens 10-36
19444535-4 2009 The aim of this study was to evaluate whether treatment with the antioxidant molecule uric acid (UA) decreased the levels of MMP-9 in stroke patients treated with rtPA. Uric Acid 86-95 matrix metallopeptidase 9 Homo sapiens 125-130
19444535-4 2009 The aim of this study was to evaluate whether treatment with the antioxidant molecule uric acid (UA) decreased the levels of MMP-9 in stroke patients treated with rtPA. Uric Acid 97-99 matrix metallopeptidase 9 Homo sapiens 125-130
19048302-9 2009 Urinary TGF beta1 concentration was positively correlated with eGFR (r = 0.247, P < 0.05), uric acid concentration (r = 0.333, P < 0.01), and percentage of overgrowth (r = 0.338, P < 0.01) and body mass index (BMI) centile (r = 0.274, P < 0.05). Uric Acid 94-103 transforming growth factor beta 1 Homo sapiens 8-17
19327605-11 2009 In premenopausal obese women, SHBG correlated negatively with BMI, waist circumference, fasting glucose, uric acid levels and FAI. Uric Acid 105-114 sex hormone binding globulin Homo sapiens 30-34
19041234-6 2009 Also, HS-PDPA-GOx electrode shows high selectivity towards glucose in the presence of ascorbic acid, uric acid and acetaminophen at their maximum physiological concentrations. Uric Acid 101-110 hydroxyacid oxidase 1 Homo sapiens 14-17
19333858-2 2009 We investigated the mechanism of action of uricase, which oxidizes uric acid to allantoin, in the rat. Uric Acid 67-76 urate oxidase Rattus norvegicus 43-50
19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Uric Acid 137-146 ketohexokinase Homo sapiens 48-62
19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Uric Acid 137-146 ketohexokinase Homo sapiens 64-67
19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Uric Acid 137-146 xanthine dehydrogenase Homo sapiens 155-178
19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Uric Acid 137-146 xanthine dehydrogenase Homo sapiens 180-183
19158351-7 2009 We detected XOR mRNA in HK-2 cells and confirmed its activity by identifying uric acid by mass spectrometry. Uric Acid 77-86 xanthine dehydrogenase Homo sapiens 12-15
19158351-8 2009 Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. Uric Acid 48-57 C-C motif chemokine ligand 2 Homo sapiens 80-85
19184967-1 2009 Xanthine oxidase (XOD) catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, and is a key enzyme in the pathogenesis of hyperuricemia. Uric Acid 87-96 xanthine dehydrogenase Mus musculus 0-16
19109320-2 2009 These findings include genetic variation within SLC2A9 as a key regulator of urate homeostasis, and identification of urate-anion exchanger urate transporter 1 (URAT1) and other renal uric acid transporters. Uric Acid 77-82 solute carrier family 2 member 9 Homo sapiens 48-54
19073137-2 2009 MRP4 also mediates the efflux of certain cyclic nucleotides, eicosanoids, conjugated steroids, and uric acid. Uric Acid 99-108 ATP binding cassette subfamily C member 4 Homo sapiens 0-4
19201844-0 2009 A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity. Uric Acid 28-44 immunoglobulin heavy constant mu Mus musculus 10-13
19201844-4 2009 We report in this study that a group of IgM Abs is able to bind to these crystals, which is interesting in light that B cell-deficient mice do not sense the proinflammatory adjuvant effect of uric acid. Uric Acid 192-201 immunoglobulin heavy constant mu Mus musculus 40-43
19201844-7 2009 The purified IgM Abs can significantly facilitate uric acid precipitation to form the inflammatory crystals in vitro. Uric Acid 50-59 immunoglobulin heavy constant mu Mus musculus 13-16
18390571-0 2009 Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process. Uric Acid 12-40 interleukin 1 beta Homo sapiens 87-105
18390571-0 2009 Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process. Uric Acid 12-40 caspase 1 Homo sapiens 137-146
18390571-8 2009 Urate crystals amplified IL1 beta production stimulated by the TLR4 ligand LPS, while no synergy was apparent for IL6 production. Uric Acid 0-5 interleukin 1 beta Homo sapiens 25-33
18390571-8 2009 Urate crystals amplified IL1 beta production stimulated by the TLR4 ligand LPS, while no synergy was apparent for IL6 production. Uric Acid 0-5 toll like receptor 4 Homo sapiens 63-67
18390571-10 2009 The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta. Uric Acid 20-25 NLR family pyrin domain containing 3 Homo sapiens 76-81
18390571-10 2009 The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta. Uric Acid 20-25 interleukin 1 beta Homo sapiens 131-139
18390571-10 2009 The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta. Uric Acid 20-25 interleukin 1 beta Homo sapiens 131-134
18390571-11 2009 The synergy between LPS and MSU crystals ceased to exist in the presence of a caspase 1 inhibitor. Uric Acid 28-31 caspase 1 Homo sapiens 78-87
19552838-8 2009 Partial correlation analyses showed that the serum Chemerin was positively correlated with waist circumference, WHR, fasting serum C peptide, HOMA-IR, TG, ALT, gamma-GT, and uric acid (r = 0.460 - 0.182, all P < 0.05) and negatively correlated with high density lipoprotein-cholesterol (r = -0.251, P < 0.01). Uric Acid 174-183 retinoic acid receptor responder 2 Homo sapiens 51-59
19260141-6 2009 Nine of SNPs implicated the role of SLC2A9 in uric acid regulation (P=4.10 x 10(-6)-2.58 x 10(-12)), as previously found in other populations. Uric Acid 46-55 solute carrier family 2 member 9 Homo sapiens 36-42
19001525-1 2009 BACKGROUND: Elevated serum uric acid is associated with several cardiovascular disease (CVD) risk factors such as hypertension, inflammation, endothelial dysfunction, insulin resistance, dyslipidemia, and obesity. Uric Acid 27-36 insulin Homo sapiens 167-174
19690404-0 2009 KLOTHO gene polymorphisms G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in Japanese hemodialysis patients. Uric Acid 104-113 klotho Homo sapiens 0-6
19057377-2 2009 More recently, it was shown that uric acid crystals stimulate dendritic cell maturation, activate the NALP3 inflammasome, and enhance antigen-specific immune responses. Uric Acid 33-42 NLR family pyrin domain containing 3 Homo sapiens 102-107
19057377-8 2009 Furthermore, primary human T cells and Jurkat T cells treated with uric acid overexpress the costimulatory molecule CD70, which plays an important role in T cell-B cell interaction and antibody production. Uric Acid 67-76 CD70 molecule Homo sapiens 116-120
19690404-7 2009 CONCLUSION: KLOTHO gene SNPs G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in HD patients. Uric Acid 107-116 klotho Homo sapiens 12-18
19526867-5 2009 HU with decreased UA excretion ("kidney" HU) was characteristic of severe DM2 with reduced kidney filtration rate. Uric Acid 18-20 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 74-77
18262738-12 2009 Uric acid prevented SIN-1-induced capacitation and significantly diminished capacitation induced by heparin or SNP. Uric Acid 0-9 MAPK associated protein 1 Homo sapiens 20-25
18585721-2 2009 With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance, the metabolic syndrome and renal failure. Uric Acid 79-88 insulin Homo sapiens 199-206
19814819-3 2009 We examined whether alpha-melanocyte-stimulating hormone (alpha-MSH) and its synthetic derivative (CKPV)2 influence urate crystal-induced monocyte (Mo) activation and neutrophil responses in vitro. Uric Acid 116-121 proopiomelanocortin Homo sapiens 20-56
19814819-4 2009 METHODS: Purified Mos were stimulated with monosodium urate (MSU) crystals in the presence or absence of melanocortin peptides. Uric Acid 43-59 MOS proto-oncogene, serine/threonine kinase Homo sapiens 18-21
19814819-4 2009 METHODS: Purified Mos were stimulated with monosodium urate (MSU) crystals in the presence or absence of melanocortin peptides. Uric Acid 61-64 MOS proto-oncogene, serine/threonine kinase Homo sapiens 18-21
19133987-2 2009 Allopurinol works by inhibiting xanthine oxidase (XO), the enzyme responsible for converting hypoxanthine to uric acid which is deposited as crystals in the joints of gout sufferers. Uric Acid 109-118 xanthine dehydrogenase Mus musculus 32-48
19133987-2 2009 Allopurinol works by inhibiting xanthine oxidase (XO), the enzyme responsible for converting hypoxanthine to uric acid which is deposited as crystals in the joints of gout sufferers. Uric Acid 109-118 xanthine dehydrogenase Mus musculus 50-52
19575548-7 2009 Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, gamma-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Uric Acid 161-170 C-reactive protein Homo sapiens 206-209
19526867-9 2009 The results suggest the significance of insulin resistance and abdominal obesity in UA metabolism in DM2. Uric Acid 84-86 insulin Homo sapiens 40-47
19255965-3 2009 In addition to research in humans, the study of different strains of knock-out mice let us include the gene of phosphate reabsorption carrier NPT2, caveolin-1, protein NHERF-1 modulating calcium and urate reabsorption, osteopontin and Tamm-Horsfall protein among the possible determinants. Uric Acid 199-204 solute carrier family 34 (sodium phosphate), member 1 Mus musculus 142-146
19526867-9 2009 The results suggest the significance of insulin resistance and abdominal obesity in UA metabolism in DM2. Uric Acid 84-86 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 101-104
19120479-6 2009 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of microbial components and in response to crystalline substances such as the endogenous danger signal uric acid. Uric Acid 179-188 NLR family, pyrin domain containing 3 Mus musculus 0-9
19255965-3 2009 In addition to research in humans, the study of different strains of knock-out mice let us include the gene of phosphate reabsorption carrier NPT2, caveolin-1, protein NHERF-1 modulating calcium and urate reabsorption, osteopontin and Tamm-Horsfall protein among the possible determinants. Uric Acid 199-204 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 168-175
19273066-2 2009 Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR activity, leading to both increased production of reactive oxygen species and uric acid, is implicated in heart failure. Uric Acid 154-163 xanthine dehydrogenase Homo sapiens 0-23
19273066-2 2009 Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR activity, leading to both increased production of reactive oxygen species and uric acid, is implicated in heart failure. Uric Acid 154-163 xanthine dehydrogenase Homo sapiens 25-28
19273066-2 2009 Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR activity, leading to both increased production of reactive oxygen species and uric acid, is implicated in heart failure. Uric Acid 154-163 xanthine dehydrogenase Homo sapiens 72-75
19120479-6 2009 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of microbial components and in response to crystalline substances such as the endogenous danger signal uric acid. Uric Acid 179-188 NLR family, pyrin domain containing 3 Mus musculus 10-15
19120479-6 2009 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of microbial components and in response to crystalline substances such as the endogenous danger signal uric acid. Uric Acid 179-188 caspase 1 Mus musculus 25-34
19378798-7 2009 AST-120 led to greater improvement of DeltaeCCr in patients with an DeltaeCCr of less than -10 mL/min/year before AST-120 treatment and who had higher blood uric acid, urinary protein, and urinary specific gravity valves. Uric Acid 157-166 solute carrier family 17 member 5 Homo sapiens 0-3
19081307-1 2009 Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 71-78
19081307-1 2009 Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. Uric Acid 11-13 urate oxidase (pseudogene) Homo sapiens 71-78
19026395-8 2008 These findings also enable us to propose a physiological model of the renal urate reabsorption in which GLUT9 regulates serum urate levels in humans and can be a promising therapeutic target for gout and related cardiovascular diseases. Uric Acid 76-81 solute carrier family 2 member 9 Homo sapiens 104-109
19306160-1 2009 OBJECTIVES: The human urate transporter 1 (URAT1, encoded by SLC22A12) was recently identified as the major absorptive urate transporter protein in the kidney responsible for regulating blood urate levels. Uric Acid 22-27 solute carrier family 22 member 12 Homo sapiens 43-48
19306160-1 2009 OBJECTIVES: The human urate transporter 1 (URAT1, encoded by SLC22A12) was recently identified as the major absorptive urate transporter protein in the kidney responsible for regulating blood urate levels. Uric Acid 22-27 solute carrier family 22 member 12 Homo sapiens 61-69
18649042-9 2008 The clinical characteristics and the remaining biochemical parameters studied were similar for the two groups, except for a significantly decreased plasmatic level of uric acid in DM1 patients. Uric Acid 167-176 immunoglobulin heavy diversity 1-7 Homo sapiens 180-183
18945957-7 2008 Knocking down Mrp4 expression resulted in a reduction of transepithelial urate secretion to 35% of control with no effects on TER or Iglu. Uric Acid 73-78 ATP binding cassette subfamily C member 4 Homo sapiens 14-18
18815025-2 2008 The scheme is based on the measurement of the consumption of oxygen during the oxidation of uric acid that is catalyzed by the enzyme uricase. Uric Acid 92-101 urate oxidase (pseudogene) Homo sapiens 134-141
19092327-9 2008 Polymerase chain reaction of a urate anion exchanger known to regulate blood urate level (SLC22A12 gene: URAT1) demonstrated that homozygous mutations in exon 4 (W258X). Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 90-98
19092327-9 2008 Polymerase chain reaction of a urate anion exchanger known to regulate blood urate level (SLC22A12 gene: URAT1) demonstrated that homozygous mutations in exon 4 (W258X). Uric Acid 31-36 solute carrier family 22 member 12 Homo sapiens 105-110
18640024-2 2008 Pd/CNFs modified carbon paste electrode (Pd/CNF-CPE) displayed excellent electrochemical catalytic activities towards dopamine (DA), uric acid (UA) and ascorbic acid (AA). Uric Acid 133-142 NPHS1 adhesion molecule, nephrin Homo sapiens 3-6
18640024-2 2008 Pd/CNFs modified carbon paste electrode (Pd/CNF-CPE) displayed excellent electrochemical catalytic activities towards dopamine (DA), uric acid (UA) and ascorbic acid (AA). Uric Acid 133-142 carboxypeptidase E Homo sapiens 48-51
18640024-2 2008 Pd/CNFs modified carbon paste electrode (Pd/CNF-CPE) displayed excellent electrochemical catalytic activities towards dopamine (DA), uric acid (UA) and ascorbic acid (AA). Uric Acid 144-146 NPHS1 adhesion molecule, nephrin Homo sapiens 3-6
18640024-2 2008 Pd/CNFs modified carbon paste electrode (Pd/CNF-CPE) displayed excellent electrochemical catalytic activities towards dopamine (DA), uric acid (UA) and ascorbic acid (AA). Uric Acid 144-146 carboxypeptidase E Homo sapiens 48-51
19026395-3 2008 However, hypouricemic patients without URAT1 mutations, as well as genome-wide association studies between urate and SLC2A9 (also called GLUT9), imply that GLUT9 could be another causative gene of renal hypouricemia. Uric Acid 107-112 solute carrier family 2 member 9 Homo sapiens 117-123
19026395-3 2008 However, hypouricemic patients without URAT1 mutations, as well as genome-wide association studies between urate and SLC2A9 (also called GLUT9), imply that GLUT9 could be another causative gene of renal hypouricemia. Uric Acid 107-112 solute carrier family 2 member 9 Homo sapiens 156-161
19026395-6 2008 The oocyte expression study revealed that both GLUT9 isoforms showed high urate transport activities, whereas the mutated GLUT9 isoforms markedly reduced them. Uric Acid 74-79 solute carrier family 2 member 9 Homo sapiens 47-52
19026395-7 2008 Our findings, together with previous reports on GLUT9 localization, suggest that these GLUT9 mutations cause renal hypouricemia by their decreased urate reabsorption on both sides of the renal proximal tubules. Uric Acid 147-152 solute carrier family 2 member 9 Homo sapiens 48-53
19026395-7 2008 Our findings, together with previous reports on GLUT9 localization, suggest that these GLUT9 mutations cause renal hypouricemia by their decreased urate reabsorption on both sides of the renal proximal tubules. Uric Acid 147-152 solute carrier family 2 member 9 Homo sapiens 87-92
19026395-8 2008 These findings also enable us to propose a physiological model of the renal urate reabsorption in which GLUT9 regulates serum urate levels in humans and can be a promising therapeutic target for gout and related cardiovascular diseases. Uric Acid 126-131 solute carrier family 2 member 9 Homo sapiens 104-109
18715993-5 2008 Here, it is reported that monosodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to the release of IL-8, von Willebrand factor, and angiopoietin 2 in the culture medium or circulation. Uric Acid 26-42 chemokine (C-X-C motif) ligand 15 Mus musculus 143-147
18824160-0 2008 T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects. Uric Acid 62-71 solute carrier family 22 member 12 Homo sapiens 23-31
18824160-1 2008 BACKGROUND AND OBJECT: It has been suggested that the SLC22A12 gene polymorphism may be involved in the mechanism of renal urate handling. Uric Acid 123-128 solute carrier family 22 member 12 Homo sapiens 54-62
18824160-2 2008 The purpose of the current study was to identify the effect of the T6092C polymorphism of the SLC22A12 gene on serum uric acid concentrations in the Korean population. Uric Acid 117-126 solute carrier family 22 member 12 Homo sapiens 94-102
18824160-12 2008 The T6092C polymorphism of the SLC22A12 gene, serum creatinine, and the FEUA were significantly associated with the concentration of serum uric acid. Uric Acid 139-148 solute carrier family 22 member 12 Homo sapiens 31-39
18824160-13 2008 CONCLUSION: This study showed that the T6092C polymorphism of the SLC22A12 gene may be involved in renal urate handling and the concentration of serum uric acid, in male subjects. Uric Acid 105-110 solute carrier family 22 member 12 Homo sapiens 66-74
18824160-13 2008 CONCLUSION: This study showed that the T6092C polymorphism of the SLC22A12 gene may be involved in renal urate handling and the concentration of serum uric acid, in male subjects. Uric Acid 151-160 solute carrier family 22 member 12 Homo sapiens 66-74
18799720-2 2008 In this study, data from 21,475 healthy volunteers who were followed prospectively for a median of 7 yr were analyzed to examine the association between uric acid level and incident kidney disease (estimated GFR [eGFR] <60 ml/min per 1.73 m(2)). Uric Acid 153-162 Rap guanine nucleotide exchange factor 5 Homo sapiens 208-211
18724382-4 2008 Recently, we identified the multidrug resistance protein (MRP) 4 as a luminal efflux transporter for urate in the proximal tubule. Uric Acid 101-106 ATP binding cassette subfamily C member 4 Homo sapiens 28-64
18715993-5 2008 Here, it is reported that monosodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to the release of IL-8, von Willebrand factor, and angiopoietin 2 in the culture medium or circulation. Uric Acid 26-42 angiopoietin 2 Mus musculus 176-190
18715993-5 2008 Here, it is reported that monosodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to the release of IL-8, von Willebrand factor, and angiopoietin 2 in the culture medium or circulation. Uric Acid 44-47 chemokine (C-X-C motif) ligand 15 Mus musculus 143-147
18715993-5 2008 Here, it is reported that monosodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to the release of IL-8, von Willebrand factor, and angiopoietin 2 in the culture medium or circulation. Uric Acid 44-47 angiopoietin 2 Mus musculus 176-190
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 4 Mus musculus 30-50
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 4 Mus musculus 52-57
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 2 Mus musculus 63-68
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 4 Mus musculus 170-175
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 chemokine (C-X-C motif) ligand 15 Mus musculus 214-218
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 2 Mus musculus 233-238
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 102-111 toll-like receptor 4 Mus musculus 170-175
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 185-194 toll-like receptor 4 Mus musculus 30-50
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 185-194 toll-like receptor 4 Mus musculus 52-57
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 185-194 toll-like receptor 2 Mus musculus 63-68
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 185-194 chemokine (C-X-C motif) ligand 15 Mus musculus 214-218
18715993-9 2008 Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid-induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid-induced release of IL-8 requires both TLR-2 and TLR-4. Uric Acid 185-194 toll-like receptor 2 Mus musculus 233-238
18846045-7 2008 Furthermore, HMW adiponectin was significantly positively correlated with high-density lipoprotein (HDL)-cholesterol and serum apolipoprotein A1, and negatively with BMI, triglycerides, homeostatic model assessment (HOMA)-index, leptin, liver transaminases, and uric acid. Uric Acid 262-271 adiponectin, C1Q and collagen domain containing Homo sapiens 17-28
18924118-7 2008 LentiPNP transduced PNP (-/-) BM cells transplanted into PNP (-/-) mice expressed PNP in vivo, partially restored urinary uric acid secretion, improved thymocytes maturation, increased weight gain and extended survival of the mice. Uric Acid 122-131 purine-nucleoside phosphorylase Mus musculus 5-8
18924118-7 2008 LentiPNP transduced PNP (-/-) BM cells transplanted into PNP (-/-) mice expressed PNP in vivo, partially restored urinary uric acid secretion, improved thymocytes maturation, increased weight gain and extended survival of the mice. Uric Acid 122-131 purine-nucleoside phosphorylase Mus musculus 20-23
18924118-7 2008 LentiPNP transduced PNP (-/-) BM cells transplanted into PNP (-/-) mice expressed PNP in vivo, partially restored urinary uric acid secretion, improved thymocytes maturation, increased weight gain and extended survival of the mice. Uric Acid 122-131 purine-nucleoside phosphorylase Mus musculus 20-23
18845806-2 2008 The xanthine oxidase inhibitor allopurinol lowers uric acid but also attenuates expression of inflammatory adhesion molecules in murine models, reduces oxidative stress in the vasculature, and improves endothelial function. Uric Acid 50-59 xanthine dehydrogenase Mus musculus 4-20
18718550-6 2008 In patients, PAF-AH activity was correlated with age, HbA1c, uric acid, HDL-cholesterol, cholesterol, LDL-cholesterol, cholesterol/HDL-cholesterol ratio and the LDL-cholesterol/HDL-cholesterol ratio. Uric Acid 61-70 phospholipase A2 group VII Homo sapiens 13-19
19106513-5 2008 Eleven days following the administration of docetaxel: 30 mg/m2 and nedaplatin: 30 mg/m2, the patient developed TLS (serum creatinine: 8.57 mg/dL, uric acid: 11.0 mg/dL, serum potassium: 6.3 mEq/L, serum phosphorus: 7.18 mg/dL). Uric Acid 147-156 FUS RNA binding protein Homo sapiens 112-115
19006690-3 2008 (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. Uric Acid 40-42 spleen associated tyrosine kinase Homo sapiens 57-60
18954524-0 2008 Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells. Uric Acid 0-9 endothelin 1 Homo sapiens 21-33
18954524-5 2008 Antioxidant pretreatments on uric acid-induced extracellular signal-regulated kinases (ERK) phosphorylation were carried out to elucidate the redox-sensitive pathway in proliferation and ET-1 gene expression. Uric Acid 29-38 mitogen-activated protein kinase 1 Homo sapiens 47-85
18954524-5 2008 Antioxidant pretreatments on uric acid-induced extracellular signal-regulated kinases (ERK) phosphorylation were carried out to elucidate the redox-sensitive pathway in proliferation and ET-1 gene expression. Uric Acid 29-38 mitogen-activated protein kinase 1 Homo sapiens 87-90
18954524-5 2008 Antioxidant pretreatments on uric acid-induced extracellular signal-regulated kinases (ERK) phosphorylation were carried out to elucidate the redox-sensitive pathway in proliferation and ET-1 gene expression. Uric Acid 29-38 endothelin 1 Homo sapiens 187-191
18954524-6 2008 RESULTS: Uric acid was found to increase HASMC proliferation, ET-1 expression and reactive oxygen species production. Uric Acid 9-18 endothelin 1 Homo sapiens 62-66
18954524-8 2008 Furthermore, apocynin, and p47phox small interfering RNA knockdown inhibited ET-1 secretion and cell proliferation induced by uric acid. Uric Acid 126-135 neutrophil cytosolic factor 1 Homo sapiens 27-34
18954524-8 2008 Furthermore, apocynin, and p47phox small interfering RNA knockdown inhibited ET-1 secretion and cell proliferation induced by uric acid. Uric Acid 126-135 endothelin 1 Homo sapiens 77-81
18954524-9 2008 Inhibition of ERK by U0126 (1,4-diamino-2,3-dicyano- 1,4-bis[2-aminophenylthio]butadiene) significantly suppressed uric acid-induced ET-1 expression, implicating this pathway in the response to uric acid. Uric Acid 115-124 mitogen-activated protein kinase 1 Homo sapiens 14-17
18954524-9 2008 Inhibition of ERK by U0126 (1,4-diamino-2,3-dicyano- 1,4-bis[2-aminophenylthio]butadiene) significantly suppressed uric acid-induced ET-1 expression, implicating this pathway in the response to uric acid. Uric Acid 115-124 endothelin 1 Homo sapiens 133-137
18954524-9 2008 Inhibition of ERK by U0126 (1,4-diamino-2,3-dicyano- 1,4-bis[2-aminophenylthio]butadiene) significantly suppressed uric acid-induced ET-1 expression, implicating this pathway in the response to uric acid. Uric Acid 194-203 mitogen-activated protein kinase 1 Homo sapiens 14-17
18954524-10 2008 In addition, uric acid increased the transcription factor activator protein-1 (AP-1) mediated reporter activity, as well as the ERK phosphorylation. Uric Acid 13-22 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-77
18954524-10 2008 In addition, uric acid increased the transcription factor activator protein-1 (AP-1) mediated reporter activity, as well as the ERK phosphorylation. Uric Acid 13-22 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 79-83
18954524-10 2008 In addition, uric acid increased the transcription factor activator protein-1 (AP-1) mediated reporter activity, as well as the ERK phosphorylation. Uric Acid 13-22 mitogen-activated protein kinase 1 Homo sapiens 128-131
18954524-11 2008 Mutational analysis of the ET-1 gene promoter showed that the AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 112-121 endothelin 1 Homo sapiens 27-31
18954524-11 2008 Mutational analysis of the ET-1 gene promoter showed that the AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 112-121 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 62-66
18954524-11 2008 Mutational analysis of the ET-1 gene promoter showed that the AP-1 binding site was an important cis-element in uric acid-induced ET-1 gene expression. Uric Acid 112-121 endothelin 1 Homo sapiens 130-134
18954524-12 2008 CONCLUSION: This is the first observation of ET-1 regulation by uric acid in HASMC, which implicates the important role of uric acid in the vascular changes associated with hypertension and vascular diseases. Uric Acid 64-73 endothelin 1 Homo sapiens 45-49
18954524-12 2008 CONCLUSION: This is the first observation of ET-1 regulation by uric acid in HASMC, which implicates the important role of uric acid in the vascular changes associated with hypertension and vascular diseases. Uric Acid 123-132 endothelin 1 Homo sapiens 45-49
18815241-7 2008 After adjustment for age, gender, and race/ethnicity, uric acid and blood urea nitrogen were significantly associated with cystatin C levels. Uric Acid 54-63 cystatin C Homo sapiens 123-133
18815241-8 2008 CONCLUSIONS: Serum cystatin C is significantly related to gender, age, race/ethnicity, uric acid, and blood urea nitrogen in adolescents. Uric Acid 87-96 cystatin C Homo sapiens 19-29
18973209-0 2008 Elevated serum retinol-binding protein 4 concentrations are associated with renal dysfunction and uric acid in type 2 diabetic patients. Uric Acid 98-107 retinol binding protein 4 Homo sapiens 15-40
18973209-1 2008 BACKGROUND: While some studies have reported that retinol-binding protein 4 (RBP4) might induce insulin resistance, other studies have demonstrated that the presence of albuminuria in diabetic patients and increased uric acid are related to insulin resistance. Uric Acid 216-225 retinol binding protein 4 Homo sapiens 77-81
18973209-1 2008 BACKGROUND: While some studies have reported that retinol-binding protein 4 (RBP4) might induce insulin resistance, other studies have demonstrated that the presence of albuminuria in diabetic patients and increased uric acid are related to insulin resistance. Uric Acid 216-225 insulin Homo sapiens 241-248
18973209-8 2008 Serum RBP4 in diabetic subjects was positively correlated with triglycerides, uric acid and ACR, and negatively correlated with low-density lipoprotein cholesterol and estimated glomerular filtration rate (eGFR; with age and gender adjustment in each parameter). Uric Acid 78-87 retinol binding protein 4 Homo sapiens 6-10
18973209-9 2008 Multiple stepwise linear regression analysis showed that uric acid and eGFR remained significantly associated with serum RBP4. Uric Acid 57-66 retinol binding protein 4 Homo sapiens 121-125
18973209-10 2008 CONCLUSIONS: Both eGFR and uric acid are significant determinants of serum RBP4, suggesting that the impaired renal clearance of early diabetic nephropathy affects RBP4 and indirectly supporting the hypothesized link among metabolic syndrome, uric acid and insulin resistance. Uric Acid 27-36 retinol binding protein 4 Homo sapiens 75-79
18784379-6 2008 We explored cellular mechanisms by which UA might cause reduced NO production focusing on the effects of UA on the l-arginine-endothelial NO synthase (eNOS) and l-arginine-arginase pathways. Uric Acid 105-107 nitric oxide synthase 3 Rattus norvegicus 151-155
18973209-10 2008 CONCLUSIONS: Both eGFR and uric acid are significant determinants of serum RBP4, suggesting that the impaired renal clearance of early diabetic nephropathy affects RBP4 and indirectly supporting the hypothesized link among metabolic syndrome, uric acid and insulin resistance. Uric Acid 243-252 retinol binding protein 4 Homo sapiens 75-79
18675899-9 2008 Another DAMP molecule, monosodium urate, also induced MnSOD expression in hepatocyte AML-12 and FaO cell cultures. Uric Acid 23-39 superoxide dismutase 2, mitochondrial Mus musculus 54-59
18854744-3 2008 Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system. Uric Acid 0-9 renin Homo sapiens 121-126
18060751-0 2008 Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Uric Acid 89-98 insulin Homo sapiens 5-12
18060751-2 2008 BACKGROUND AND AIMS: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Uric Acid 134-143 insulin Homo sapiens 47-54
18989453-12 2008 The Dalmatian dog model of hyperuricosuria and hyperuricemia underscores the importance of SLC2A9 for uric acid transport in mammals. Uric Acid 102-111 solute carrier family 2 member 9 Canis lupus familiaris 91-97
18772145-1 2008 The xanthine oxidoreductase gene (XOR) encodes an important source of reactive oxygen species and uric acid, and its expression is associated with various human diseases including several forms of cancer. Uric Acid 98-107 xanthine dehydrogenase Homo sapiens 4-27
18772145-1 2008 The xanthine oxidoreductase gene (XOR) encodes an important source of reactive oxygen species and uric acid, and its expression is associated with various human diseases including several forms of cancer. Uric Acid 98-107 xanthine dehydrogenase Homo sapiens 34-37
18701466-9 2008 The in vivo role of GLUT9 is supported by the fact that a renal hypouricemia patient without any mutations in SLC22A12 was found to have a missense mutation in SLC2A9, which reduced urate transport activity in vitro. Uric Acid 182-187 solute carrier family 2 member 9 Homo sapiens 20-25
18701466-0 2008 Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. Uric Acid 7-12 solute carrier family 2 member 9 Homo sapiens 86-92
18842065-2 2008 Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. Uric Acid 120-125 solute carrier family 2 member 9 Homo sapiens 75-81
18842065-3 2008 The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. Uric Acid 157-162 solute carrier family 2 member 9 Homo sapiens 4-10
18842065-4 2008 We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man. Uric Acid 47-52 solute carrier family 2 member 9 Homo sapiens 24-30
18842065-5 2008 METHODS AND FINDINGS: We expressed both SLC2A9 splice variants in Xenopus laevis oocytes and found both isoforms mediate rapid urate fluxes at concentration ranges similar to physiological serum levels (200-500 microM). Uric Acid 127-132 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 40-46
18842065-7 2008 We found that urate is transported by SLC2A9 at rates 45- to 60-fold faster than glucose, and demonstrated that SLC2A9-mediated urate transport is facilitated by glucose and, to a lesser extent, fructose. Uric Acid 14-19 solute carrier family 2 member 9 Homo sapiens 38-44
18842065-7 2008 We found that urate is transported by SLC2A9 at rates 45- to 60-fold faster than glucose, and demonstrated that SLC2A9-mediated urate transport is facilitated by glucose and, to a lesser extent, fructose. Uric Acid 14-19 solute carrier family 2 member 9 Homo sapiens 112-118
18842065-7 2008 We found that urate is transported by SLC2A9 at rates 45- to 60-fold faster than glucose, and demonstrated that SLC2A9-mediated urate transport is facilitated by glucose and, to a lesser extent, fructose. Uric Acid 128-133 solute carrier family 2 member 9 Homo sapiens 112-118
18842065-9 2008 Furthermore, we found urate uptake was at least 2-fold greater in human embryonic kidney (HEK) cells overexpressing SLC2A9 splice variants than nontransfected kidney cells. Uric Acid 22-27 solute carrier family 2 member 9 Homo sapiens 116-122
18842065-11 2008 In a cohort of men we showed that genetic variants of SLC2A9 are associated with reduced urinary urate clearance, which fits with common variation at SLC2A9 leading to increased serum urate. Uric Acid 97-102 solute carrier family 2 member 9 Homo sapiens 54-60
18842065-11 2008 In a cohort of men we showed that genetic variants of SLC2A9 are associated with reduced urinary urate clearance, which fits with common variation at SLC2A9 leading to increased serum urate. Uric Acid 97-102 solute carrier family 2 member 9 Homo sapiens 150-156
18701466-0 2008 Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. Uric Acid 7-12 solute carrier family 2 member 9 Homo sapiens 94-100
18701466-4 2008 However, it is not known how urate taken up by URAT1 exits from the tubular cell to the systemic circulation. Uric Acid 29-34 solute carrier family 22 member 12 Homo sapiens 47-52
18701466-5 2008 Here, we report that a sugar transport facilitator family member protein GLUT9 (SLC2A9) functions as an efflux transporter of urate from the tubular cell. Uric Acid 126-131 solute carrier family 2 member 9 Homo sapiens 73-78
18701466-5 2008 Here, we report that a sugar transport facilitator family member protein GLUT9 (SLC2A9) functions as an efflux transporter of urate from the tubular cell. Uric Acid 126-131 solute carrier family 2 member 9 Homo sapiens 80-86
18701466-6 2008 GLUT9-expressed Xenopus oocytes mediated saturable urate transport (K(m): 365+/-42 microm). Uric Acid 51-56 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 0-5
18842065-11 2008 In a cohort of men we showed that genetic variants of SLC2A9 are associated with reduced urinary urate clearance, which fits with common variation at SLC2A9 leading to increased serum urate. Uric Acid 184-189 solute carrier family 2 member 9 Homo sapiens 54-60
18842065-11 2008 In a cohort of men we showed that genetic variants of SLC2A9 are associated with reduced urinary urate clearance, which fits with common variation at SLC2A9 leading to increased serum urate. Uric Acid 184-189 solute carrier family 2 member 9 Homo sapiens 150-156
18701466-9 2008 The in vivo role of GLUT9 is supported by the fact that a renal hypouricemia patient without any mutations in SLC22A12 was found to have a missense mutation in SLC2A9, which reduced urate transport activity in vitro. Uric Acid 182-187 solute carrier family 2 member 9 Homo sapiens 160-166
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 63-68 solute carrier family 22 member 12 Homo sapiens 145-150
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 63-68 solute carrier family 2 member 9 Homo sapiens 196-201
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 63-68 solute carrier family 2 member 9 Homo sapiens 231-237
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 94-99 solute carrier family 22 member 12 Homo sapiens 145-150
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 94-99 solute carrier family 2 member 9 Homo sapiens 196-201
18701466-10 2008 Based on these data, we propose a novel model of transcellular urate transport in the kidney; urate [corrected] is taken up via apically located URAT1 and exits the cell via basolaterally located GLUT9, which we suggest be renamed URATv1 (voltage-driven urate transporter 1). Uric Acid 94-99 solute carrier family 2 member 9 Homo sapiens 231-237
18683214-5 2008 RESULTS: Higher TNF-alpha levels were found to correlate with poorer performance status; higher leukocyte counts; higher levels of beta2-microglobulin, creatinine, uric acid, and alkaline phosphatase; lower levels of creatinine clearance and albumin; baseline infection; and M4-M5 AML subtypes. Uric Acid 164-173 tumor necrosis factor Homo sapiens 16-25
18701632-11 2008 Mild hyperuricemia induced by uricase inhibition causes intrarenal oxidative stress, which contributes to the development of the systemic hypertension and the renal abnormalities induced by increased uric acid. Uric Acid 200-209 urate oxidase Rattus norvegicus 30-37
18710901-7 2008 When we further adjusted for serum uric acid levels, the association remained significant (RR 1.26; 95% CI 1.02, 1.54). Uric Acid 35-44 ribonucleotide reductase catalytic subunit M1 Homo sapiens 91-95
19080294-7 2008 RESULTS: When the serum uric acid level was more than 380 micromol/L, the levels of plasma MDA, SOD, GSH-Px, PAI-1 and ET-1 became higher, while the level NO became lower (P < 0.05). Uric Acid 24-33 endothelin 1 Homo sapiens 119-123
18565955-9 2008 Elevated levels of GDF-15 were associated with increased mean right atrial and pulmonary capillary wedge pressures, a lower mixed venous oxygen saturation (Sv(O(2))), and higher levels of uric acid and N-terminal pro-brain natriuretic peptide (NT-proBNP). Uric Acid 188-197 growth differentiation factor 15 Homo sapiens 19-25
18492088-2 2008 Impairment of the function of URAT1, the main transporter for the reabsorption of uric acid at the apical membrane of the renal tubules, causes renal hypouricemia. Uric Acid 82-91 solute carrier family 22 member 12 Homo sapiens 30-35
18715799-4 2008 The fact that several stimuli, including bacterial toxins and some viruses, but also sterile crystals made of uric acid, asbestos or aluminium hydroxide, can trigger the Nalp3 inflammasome illustrate the fascinating prospect that microbial infections and certain danger signals may be perceived similarly by host recognition systems. Uric Acid 110-119 NLR family pyrin domain containing 3 Homo sapiens 170-175
20209780-5 2008 In women with preeclampsia, CRP correlated positively and significantly with diastolic blood pressure, proteinuria and uric acid levels. Uric Acid 119-128 C-reactive protein Homo sapiens 28-31
27873826-0 2008 An Amperometric Biosensor for Uric Acid Determination Prepared From Uricase Immobilized in Polyaniline-Polypyrrole Film. Uric Acid 30-39 urate oxidase (pseudogene) Homo sapiens 68-75
27873826-1 2008 A new amperometric uric acid biosensor was developed by immobilizing uricase by a glutaraldehyde crosslinking procedure on polyaniline-polypyrrole (pani-ppy) composite film on the surface of a platinum electrode. Uric Acid 19-28 urate oxidase (pseudogene) Homo sapiens 69-76
18759275-0 2008 Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. Uric Acid 66-75 solute carrier family 2 member 9 Homo sapiens 49-54
18759275-6 2008 Followup genotyping revealed that a nonsynonymous coding SNP (Val253Ile; rs16890979) in GLUT9 was most strongly associated with uric acid levels, with each copy of the minor allele associated with a decrease of 0.47 mg/dl in the uric acid level (95% confidence interval 0.31-0.63 [P = 1.43 x 10(-11)]). Uric Acid 128-137 solute carrier family 2 member 9 Homo sapiens 88-93
18759275-6 2008 Followup genotyping revealed that a nonsynonymous coding SNP (Val253Ile; rs16890979) in GLUT9 was most strongly associated with uric acid levels, with each copy of the minor allele associated with a decrease of 0.47 mg/dl in the uric acid level (95% confidence interval 0.31-0.63 [P = 1.43 x 10(-11)]). Uric Acid 229-238 solute carrier family 2 member 9 Homo sapiens 88-93
18759275-8 2008 The genotype effect was not modified by the inclusion of several cardiovascular risk factors, suggesting that GLUT9 is directly related to uric acid homeostasis. Uric Acid 139-148 solute carrier family 2 member 9 Homo sapiens 110-115
18759275-10 2008 CONCLUSION: Our findings indicate that GLUT9, which is expressed in the kidney, may be a novel regulator of uric acid elimination and that a common nonsynonymous variant in this gene contributes to abnormalities in uric acid homeostasis and gout. Uric Acid 108-117 solute carrier family 2 member 9 Homo sapiens 39-44
18759275-10 2008 CONCLUSION: Our findings indicate that GLUT9, which is expressed in the kidney, may be a novel regulator of uric acid elimination and that a common nonsynonymous variant in this gene contributes to abnormalities in uric acid homeostasis and gout. Uric Acid 215-224 solute carrier family 2 member 9 Homo sapiens 39-44
18375516-3 2008 An application is given on urate oxidase (UOX), a cofactorless enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate in the presence of dioxygen. Uric Acid 102-111 urate oxidase (pseudogene) Homo sapiens 27-40
18375516-3 2008 An application is given on urate oxidase (UOX), a cofactorless enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate in the presence of dioxygen. Uric Acid 102-111 urate oxidase (pseudogene) Homo sapiens 42-45
18328088-1 2008 Xanthine dehydrogenase/xanthine oxidase (XDH/XO) catalyses the hydroxylation of hypoxanthine to xanthine and finally to uric acid in purine degradation. Uric Acid 120-129 xanthine dehydrogenase Homo sapiens 41-47
18702943-11 2008 In contrast, both GGT activity and uric acid concentrations correlated with insulin sensitivity and co-associated with insulin resistance-related risk factors and are therefore components of a true risk factor cluster. Uric Acid 35-44 insulin Homo sapiens 76-83
18702943-11 2008 In contrast, both GGT activity and uric acid concentrations correlated with insulin sensitivity and co-associated with insulin resistance-related risk factors and are therefore components of a true risk factor cluster. Uric Acid 35-44 insulin Homo sapiens 119-126
18487473-0 2008 Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Uric Acid 83-92 solute carrier family 2 member 9 Homo sapiens 62-68
18487473-2 2008 Recently, the putative fructose transporter SLC2A9 was reported to influence uric acid levels. Uric Acid 77-86 solute carrier family 2 member 9 Homo sapiens 44-50
18487473-9 2008 CONCLUSIONS: Genetic variants within SLC2A9 have significant effects on uric acid levels and are modified by sex and BMI. Uric Acid 72-81 solute carrier family 2 member 9 Homo sapiens 37-43
18648056-4 2008 Plasma levels of glucose, urate, and total free amino acids were all significantly decreased by CORT treatment. Uric Acid 26-31 CORT Gallus gallus 96-100
19080294-7 2008 RESULTS: When the serum uric acid level was more than 380 micromol/L, the levels of plasma MDA, SOD, GSH-Px, PAI-1 and ET-1 became higher, while the level NO became lower (P < 0.05). Uric Acid 24-33 superoxide dismutase 1 Homo sapiens 96-99
19080294-7 2008 RESULTS: When the serum uric acid level was more than 380 micromol/L, the levels of plasma MDA, SOD, GSH-Px, PAI-1 and ET-1 became higher, while the level NO became lower (P < 0.05). Uric Acid 24-33 serpin family E member 1 Homo sapiens 109-114
19080294-8 2008 However SOD and GSH-Px became much lower when the serum uric acid level was more than 420 micromol/L. Uric Acid 56-65 superoxide dismutase 1 Homo sapiens 8-11
18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 NLR family pyrin domain containing 3 Homo sapiens 77-111
18638417-1 2008 BACKGROUND: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. Uric Acid 74-83 urate oxidase (pseudogene) Homo sapiens 41-44
18501514-14 2008 Plasma total antioxidant capacity was significantly decreased during the development of EAE, however it was subsided in mice treated with UA as compared to the corresponding controls (21%) in groups A and B. Elevated liver GST as a result of EAE induction was reversed in mice treated with UA particularly in groups A and B. Uric Acid 138-140 hematopoietic prostaglandin D synthase Mus musculus 223-226
18501514-14 2008 Plasma total antioxidant capacity was significantly decreased during the development of EAE, however it was subsided in mice treated with UA as compared to the corresponding controls (21%) in groups A and B. Elevated liver GST as a result of EAE induction was reversed in mice treated with UA particularly in groups A and B. Uric Acid 290-292 hematopoietic prostaglandin D synthase Mus musculus 223-226
18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 NLR family pyrin domain containing 3 Homo sapiens 113-118
18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 caspase 1 Homo sapiens 140-149
18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 interleukin 1 beta Homo sapiens 162-170
18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 selectin L Homo sapiens 199-209
18523012-5 2008 Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP. Uric Acid 149-158 interleukin 1 beta Homo sapiens 215-223
18411268-8 2008 Surprisingly, we have detected urate(-)/glutathione exchange by hOAT10, consistent with an involvement of hOAT10 in the renal glutathione cycle. Uric Acid 31-36 solute carrier family 22 member 13 Homo sapiens 64-70
18411268-9 2008 Uricosurics, diuretics, and cyclosporine A showed substantial interactions with hOAT10, of which cyclosporine A enhanced [(14)C]urate uptake, providing the first molecular evidence for cyclosporine A-induced hyperuricemia. Uric Acid 128-133 solute carrier family 22 member 13 Homo sapiens 80-86
18842173-8 2008 In conclusion, the results of the present study support the notion that serum uric acid levels may be higher in patients with BP-I (especially during manic phases) which may suggest a dysregulation of the purinergic system. Uric Acid 78-87 bactericidal permeability increasing protein Homo sapiens 126-130
18411268-0 2008 Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). Uric Acid 24-29 solute carrier family 22 member 13 Homo sapiens 72-78
18411268-0 2008 Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). Uric Acid 24-29 solute carrier family 22 member 13 Homo sapiens 80-88
18411268-2 2008 hORCTL3-expressing Xenopus laevis oocytes showed uptake of [(3)H]nicotinate, [(3)H]p-aminohippurate, and [(14)C]urate. Uric Acid 94-99 solute carrier family 22 member 13 Homo sapiens 0-7
18411268-5 2008 The pH dependence of hOAT10 suggests p-aminohippurate(-)/OH(-), urate(-)/OH(-), and nicotinate(-)/OH(-) exchange as possible transport modes. Uric Acid 48-53 solute carrier family 22 member 13 Homo sapiens 21-27
18411268-6 2008 Urate inhibited [(3)H]nicotinate transport by hOAT10 with an IC(50) value of 759 microm, assuming that hOAT10 represents a low affinity urate transporter. Uric Acid 0-5 solute carrier family 22 member 13 Homo sapiens 46-52
18411268-6 2008 Urate inhibited [(3)H]nicotinate transport by hOAT10 with an IC(50) value of 759 microm, assuming that hOAT10 represents a low affinity urate transporter. Uric Acid 0-5 solute carrier family 22 member 13 Homo sapiens 103-109
18411268-7 2008 hOAT10-mediated [(14)C]urate uptake was elevated by an exchange with l -lactate, pyrazinoate, and nicotinate. Uric Acid 23-28 solute carrier family 22 member 13 Homo sapiens 0-6
18523012-5 2008 Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP. Uric Acid 149-158 interleukin 18 Homo sapiens 228-233
18510977-13 2008 Sand flies injected with XDH dsRNA also exhibit significantly reduced life span in comparison with the mock-injected group when fed on sucrose or when rabbit blood fed, showing that urate could be indeed an important free radical scavenger in Lu. Uric Acid 182-187 xanthine dehydrogenase/oxidase Oryctolagus cuniculus 25-28
18356554-1 2008 OBJECTIVE: The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation. Uric Acid 76-85 C-reactive protein Homo sapiens 290-308
18356554-1 2008 OBJECTIVE: The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation. Uric Acid 76-85 C-reactive protein Homo sapiens 310-313
18356554-5 2008 In a Cox model, comparing extreme quartiles of the UA distribution, the hazard ratio for CVD mortality was 1.44 (95% confidence interval [CI] 1.04 to 2.0), and for all-cause mortality it was 1.40 (95% CI 1.13 to 1.74) after adjustment for conventional cardiovascular risk factors, CRP, and diuretic intake. Uric Acid 51-53 C-reactive protein Homo sapiens 281-284
18480647-6 2008 RESULTS: For males, after multivariate adjustment, the odds ratios (95% confidence interval) of elevated serum uric acid associated with high blood pressure, low HDL-cholesterol, high triglycerides, insulin resistance, and high body mass index were 2.61 (1.13, 6.03), 1.47 (0.57, 3.80), 1.30 (0.55, 3.08), 2.87 (1.23, 6.71), and 3.25 (1.36, 7.74), respectively. Uric Acid 111-120 insulin Homo sapiens 199-206
18591880-5 2008 Nitrotyrosine and adiponectin were significantly lower, while TAS, hs-CRP, E-selectin, ICAM-1, and VCAM-1 were higher in the groups with increased uric acid levels. Uric Acid 147-156 intercellular adhesion molecule 1 Homo sapiens 87-93
18591880-5 2008 Nitrotyrosine and adiponectin were significantly lower, while TAS, hs-CRP, E-selectin, ICAM-1, and VCAM-1 were higher in the groups with increased uric acid levels. Uric Acid 147-156 vascular cell adhesion molecule 1 Homo sapiens 99-105
18591880-6 2008 In a multiple regression model, after adjustments for multiple confounders, uric acid levels were inversely associated with nitrotyrosine (p<0.001) and adiponectin (p=0.02), and directly with TAS (p<0.001), and E-selectin (p=0.006). Uric Acid 76-85 adiponectin, C1Q and collagen domain containing Homo sapiens 155-166
18591880-6 2008 In a multiple regression model, after adjustments for multiple confounders, uric acid levels were inversely associated with nitrotyrosine (p<0.001) and adiponectin (p=0.02), and directly with TAS (p<0.001), and E-selectin (p=0.006). Uric Acid 76-85 selectin E Homo sapiens 217-227
18591880-7 2008 CONCLUSION: Serum uric acid showed opposite relationships, being associated with both beneficial (inverse association with nitrotyrosine, direct association with TAS) and detrimental (inverse association with adiponectin, direct association with E-selectin) markers, thus providing a possible explanation for the previously reported controversial and not linear association between uric acid and cardiovascular disease. Uric Acid 18-27 adiponectin, C1Q and collagen domain containing Homo sapiens 209-220
18591880-7 2008 CONCLUSION: Serum uric acid showed opposite relationships, being associated with both beneficial (inverse association with nitrotyrosine, direct association with TAS) and detrimental (inverse association with adiponectin, direct association with E-selectin) markers, thus providing a possible explanation for the previously reported controversial and not linear association between uric acid and cardiovascular disease. Uric Acid 18-27 selectin E Homo sapiens 246-256
18349066-10 2008 In MFTs, a correlation was found after 2 yr of therapy between the homeostasis model assessment of insulin resistance and the serum uric acid (r = 0.59; P = 0.01). Uric Acid 132-141 insulin Homo sapiens 99-106
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 219-224 discs large MAGUK scaffold protein 4 Homo sapiens 40-46
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 219-224 PDZ domain containing 1 Homo sapiens 79-84
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 219-224 solute carrier family 22 member 12 Homo sapiens 109-114
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 discs large MAGUK scaffold protein 4 Homo sapiens 40-46
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 PDZ domain containing 1 Homo sapiens 79-84
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 solute carrier family 22 member 12 Homo sapiens 109-114
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 discs large MAGUK scaffold protein 4 Homo sapiens 40-46
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 PDZ domain containing 1 Homo sapiens 79-84
18600508-2 2008 In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Uric Acid 236-241 solute carrier family 22 member 12 Homo sapiens 109-114
18600515-2 2008 We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). Uric Acid 42-47 C-reactive protein Homo sapiens 239-257
18327256-0 2008 SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Uric Acid 18-27 solute carrier family 2 member 9 Homo sapiens 0-6
18270321-6 2008 Oat1- and Oat3-null mice manifested decreased secretion rather than reabsorption, indicating that these related transporters transport urate in the "opposite" direction to RST. Uric Acid 135-140 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 0-4
18270321-6 2008 Oat1- and Oat3-null mice manifested decreased secretion rather than reabsorption, indicating that these related transporters transport urate in the "opposite" direction to RST. Uric Acid 135-140 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 10-14
18270321-8 2008 The results suggest that RST, Oat1, and Oat3 each contribute to urate handling, but, at least in mice, the bulk of reabsorption is mediated by a transporter(s) that remains to be identified. Uric Acid 64-69 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 30-34
18270321-8 2008 The results suggest that RST, Oat1, and Oat3 each contribute to urate handling, but, at least in mice, the bulk of reabsorption is mediated by a transporter(s) that remains to be identified. Uric Acid 64-69 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 40-44
17982491-4 2008 Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-gamma (IFN-gamma) and interleukin 12 (IL-12). Uric Acid 90-99 odorant binding protein 2A Homo sapiens 19-22
17982491-4 2008 Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-gamma (IFN-gamma) and interleukin 12 (IL-12). Uric Acid 90-99 interferon gamma Homo sapiens 172-188
17982491-4 2008 Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-gamma (IFN-gamma) and interleukin 12 (IL-12). Uric Acid 90-99 interferon gamma Homo sapiens 190-199
18398472-1 2008 BACKGROUND: Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations. Uric Acid 18-27 solute carrier family 2 member 9 Homo sapiens 125-130
18398472-1 2008 BACKGROUND: Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations. Uric Acid 29-31 solute carrier family 2 member 9 Homo sapiens 125-130
18397692-1 2008 UNLABELLED: Sucrose is divided by alpha-glucosidase into fructose and glucose, which are considered to raise plasma uric acid concentration through purine degradation and/or decreased uric acid excretion. Uric Acid 116-125 sucrase-isomaltase Homo sapiens 34-51
18397692-1 2008 UNLABELLED: Sucrose is divided by alpha-glucosidase into fructose and glucose, which are considered to raise plasma uric acid concentration through purine degradation and/or decreased uric acid excretion. Uric Acid 184-193 sucrase-isomaltase Homo sapiens 34-51
18397692-2 2008 AIMS: We investigated the effect of acarbose, an alpha-glucosidase inhibitor, on the increased plasma concentration of uric acid caused by sucrose. Uric Acid 119-128 sucrase-isomaltase Homo sapiens 49-66
18297716-0 2008 Is serum uric acid a predictive factor of response to IFN-treatment in patients with chronic hepatitis C infection? Uric Acid 9-18 interferon alpha 1 Homo sapiens 54-57
18375259-3 2008 With the supply of molecular oxygen upon reperfusion of ischemic tissues, xanthine oxidoreductase (XOR) metabolizes xanthine and hypoxanthine to uric acid and free radicals are generated. Uric Acid 145-154 xanthine dehydrogenase Rattus norvegicus 74-97
18375259-3 2008 With the supply of molecular oxygen upon reperfusion of ischemic tissues, xanthine oxidoreductase (XOR) metabolizes xanthine and hypoxanthine to uric acid and free radicals are generated. Uric Acid 145-154 xanthine dehydrogenase Rattus norvegicus 99-102
18375259-9 2008 We suggest that the decrease in xanthine oxidoreductase expression is one of the beneficial mechanisms of TMZ on I/R injury, preventing the degradation of purine nucleotides during the oxidation of hypoxanthine to xanthine and uric acid and formation of free radicals. Uric Acid 227-236 xanthine dehydrogenase Rattus norvegicus 32-55
18451537-1 2008 Xanthine oxidase (XO)/xanthine dehydrogenase (XD) oxidizes oxypurines to uric acid, with only the XO form producing reactive oxygen species. Uric Acid 73-82 xanthine dehydrogenase Rattus norvegicus 22-44
18712049-2 2008 Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. Uric Acid 38-43 xanthine dehydrogenase Homo sapiens 0-22
18712049-2 2008 Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. Uric Acid 38-43 xanthine dehydrogenase Homo sapiens 24-27
18390895-0 2008 Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey. Uric Acid 94-103 insulin Homo sapiens 54-61
18390895-8 2008 Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance (multivariate P-values for trend, <0.001). Uric Acid 6-15 insulin Homo sapiens 96-103
18390895-8 2008 Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance (multivariate P-values for trend, <0.001). Uric Acid 6-15 insulin Homo sapiens 114-121
18256311-5 2008 NHERF-1 null mice had increased urinary excretion of phosphate, calcium, and uric acid compared with wild-type control and NHERF-2 null mice. Uric Acid 77-86 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 0-7
18256311-8 2008 These studies indicate that the increased urinary excretion of phosphate and uric acid are specific to NHERF-1 null mice and highlight the fact that predictions about the role of adaptor proteins such as the NHERF proteins obtained from studies of model cell systems must be confirmed in whole animals. Uric Acid 77-86 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 103-110
18312403-14 2008 Mean serum UA levels significantly increased when determined during Interferon Beta or Glatiramer Acetate therapy (r: 0.84, P < 0.001). Uric Acid 11-13 interferon beta 1 Homo sapiens 68-83
18409511-1 2008 Urate, a naturally occurring product of purine metabolism, is present at higher levels in human blood than in other mammals, because humans have an effective renal urate reabsorption system in addition to their evolutionary loss of hepatic uricase by mutational silencing. Uric Acid 0-5 urate oxidase (pseudogene) Homo sapiens 240-247
18409511-2 2008 The urate transporter URAT1 encoded by SLC22A12 is a urate anion exchanger regulating blood urate levels. Uric Acid 4-9 solute carrier family 22 member 12 Homo sapiens 22-27
18409511-2 2008 The urate transporter URAT1 encoded by SLC22A12 is a urate anion exchanger regulating blood urate levels. Uric Acid 4-9 solute carrier family 22 member 12 Homo sapiens 39-47
18409511-5 2008 Recently it has been shown that the proximal tubule apical membrane organic anion transporter OAT4 transports urate at low affinity and responsible for the hyperuricemia cased by thiazide diuretics. Uric Acid 110-115 solute carrier family 22 member 11 Homo sapiens 94-98
18327256-2 2008 In the genome-wide association study KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele). Uric Acid 163-172 solute carrier family 2 member 9 Homo sapiens 221-227
18327256-4 2008 Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup (n = 117) showed a significant association between the SLC2A9 isoform 2 and urate concentrations. Uric Acid 153-158 solute carrier family 2 member 9 Homo sapiens 132-138
18327257-0 2008 SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Uric Acid 29-34 solute carrier family 2 member 9 Homo sapiens 0-6
18409511-6 2008 Transport of urate via URAT1 is driven by the intracellular lactate that is accumulated by Na+/lactate cotransporter slc5a8 and slc5a12. Uric Acid 13-18 solute carrier family 22 member 12 Homo sapiens 23-28
18327257-0 2008 SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Uric Acid 65-70 solute carrier family 2 member 9 Homo sapiens 0-6
18409511-6 2008 Transport of urate via URAT1 is driven by the intracellular lactate that is accumulated by Na+/lactate cotransporter slc5a8 and slc5a12. Uric Acid 13-18 solute carrier family 5 member 8 Homo sapiens 117-123
18327257-4 2008 We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide association scan in a Croatian population sample. Uric Acid 118-127 solute carrier family 2 member 9 Homo sapiens 63-69
18327257-5 2008 SLC2A9 variants were also associated with low fractional excretion of uric acid and/or gout in UK, Croatian and German population samples. Uric Acid 70-79 solute carrier family 2 member 9 Homo sapiens 0-6
18327257-6 2008 SLC2A9 is a known fructose transporter, and we now show that it has strong uric acid transport activity in Xenopus laevis oocytes. Uric Acid 75-84 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 0-6
18409511-6 2008 Transport of urate via URAT1 is driven by the intracellular lactate that is accumulated by Na+/lactate cotransporter slc5a8 and slc5a12. Uric Acid 13-18 solute carrier family 5 member 12 Homo sapiens 128-135
18409514-6 2008 URAT1 has highly specific urate transport activity, exchanging this anion with others including most of the endogenous organic anions and drug anions that are known to affect renal uric acid transport. Uric Acid 181-190 solute carrier family 22 member 12 Homo sapiens 0-5
17674156-2 2008 MATERIALS AND METHODS: Uptakes of uric acid by OAT1-expressing Flp293 cells, by Xenopus oocytes expressing OAT3 or OAT4, and by membrane vesicles from Sf9 cells expressing MRP4 were evaluated in the presence or absence of ARBs. Uric Acid 34-43 solute carrier family 22 member 6 Homo sapiens 47-51
18409525-3 2008 Uricosuric agents act the urate lowering effect through blocking the URAT1, an urate transporter, in brush border of renal proximal tubular cells. Uric Acid 26-31 solute carrier family 22 member 12 Homo sapiens 69-74
18409526-1 2008 Inhibitors of xanthine oxidoreductase decrease production of uric acid, thus they act as hypouricemic drugs. Uric Acid 61-70 xanthine dehydrogenase Homo sapiens 14-37
18409529-6 2008 Xanthine oxido-reductase, a key enzyme of uric acid metabolism was indicated as one of regulatory factors in adipocyte differentiation. Uric Acid 42-51 xanthine dehydrogenase Homo sapiens 0-24
18409530-1 2008 AMPD (AMP deaminase), an enzyme catalyzing AMP to IMP, plays an important role in purine/urate metabolism. Uric Acid 89-94 adenosine monophosphate deaminase 1 Homo sapiens 0-4
18409530-1 2008 AMPD (AMP deaminase), an enzyme catalyzing AMP to IMP, plays an important role in purine/urate metabolism. Uric Acid 89-94 adenosine monophosphate deaminase 1 Homo sapiens 6-19
17416371-13 2008 In stepwise linear regression analysis, we found that serum uric acid (SUA) levels independently but modestly associated with C-IMT (beta=0.42, p=0.002). Uric Acid 60-69 CIMT Homo sapiens 126-131
18369465-7 2008 Degradation of Plasmodium-derived hypoxanthine/xanthine results in the formation of uric acid, which triggers the secretion of TNF. Uric Acid 84-93 tumor necrosis factor Homo sapiens 127-130
18219300-6 2008 Higher body mass index and insulin resistance (i.e., the metabolic syndrome) may be etiologic in uric acid nephrolithiasis as increasing body weight is associated with decreasing urinary pH. Uric Acid 97-106 insulin Homo sapiens 27-34
18078816-4 2008 ZAG correlated with glucose, creatinine and uric acid. Uric Acid 44-53 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 0-3
18349750-3 2008 RECENT FINDINGS: The discovery of URAT1 has facilitated identification of other molecules potentially involved in uric acid transport in the renal tubules. Uric Acid 114-123 solute carrier family 22 member 12 Homo sapiens 34-39
18349750-10 2008 Elucidation of the mechanisms of hyperuricemia in patients with familial juvenile hyperuricemic nephropathy will shed light on the function of uromodulin, functional impairment of which eventually results in diminished uric acid excretion. Uric Acid 219-228 uromodulin Homo sapiens 143-153
18349751-7 2008 Uricase, the enzyme that catalyzes conversion of uric acid into allantoin, is showing promise with its ability to rapidly diminish serum urate levels. Uric Acid 49-58 urate oxidase (pseudogene) Homo sapiens 0-7
18349751-7 2008 Uricase, the enzyme that catalyzes conversion of uric acid into allantoin, is showing promise with its ability to rapidly diminish serum urate levels. Uric Acid 137-142 urate oxidase (pseudogene) Homo sapiens 0-7
17674156-3 2008 RESULTS: All ARBs inhibited uptake of uric acid or estrone-3-sulfate by OAT1, OAT3 and OAT4 in concentration dependent manners. Uric Acid 38-47 solute carrier family 22 member 6 Homo sapiens 72-76
17674156-3 2008 RESULTS: All ARBs inhibited uptake of uric acid or estrone-3-sulfate by OAT1, OAT3 and OAT4 in concentration dependent manners. Uric Acid 38-47 solute carrier family 22 member 8 Homo sapiens 78-82
17674156-3 2008 RESULTS: All ARBs inhibited uptake of uric acid or estrone-3-sulfate by OAT1, OAT3 and OAT4 in concentration dependent manners. Uric Acid 38-47 solute carrier family 22 member 11 Homo sapiens 87-91
17674156-5 2008 Candesartan, losartan, and telmisartan inhibited ATP-dependent uptake of uric acid by MRP4 at 10 microM. Uric Acid 73-82 ATP binding cassette subfamily C member 4 Homo sapiens 86-90
17674156-8 2008 CONCLUSION: Valsartan, olmesartan, and pratosartan could inhibit the OAT3-mediated uric acid secretion in clinical situations. Uric Acid 83-92 solute carrier family 22 member 8 Homo sapiens 69-73
17674156-9 2008 Furthermore losartan could inhibit ATP-dependent uric acid secretion by MRP4. Uric Acid 49-58 ATP binding cassette subfamily C member 4 Homo sapiens 72-76
18197691-6 2008 These nanoporous PtPb electrodes are also highly resistant toward poisoning by chloride ions and capable of sensing glucose amperometrically at a very low potential, -80 mV (Ag/AgCl), where the interference from the oxidation of common interfering species such as ascorbic acid, acetamidophenol, and uric acid is effectively avoided. Uric Acid 300-309 protein tyrosine phosphatase receptor type B Homo sapiens 17-21
18271711-6 2008 In acute stroke patients treated with recombinant tissue plasminogen activator (rt-PA), co-administration of UA has proven to reduce lipid peroxidation and to prevent the fall in UA blood levels that occur very early after stroke onset. Uric Acid 109-111 chromosome 20 open reading frame 181 Homo sapiens 50-78
18240236-12 2008 Concordance index (C statistic) analyses showed that uric acid significantly improved the predictive accuracy of a model that included Framingham Heart Study score factors, metabolic syndrome components, and fibrinogen levels. Uric Acid 53-62 fibrinogen beta chain Homo sapiens 208-218
18360072-1 2008 Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Uric Acid 100-109 xanthine dehydrogenase Homo sapiens 0-23
18192841-6 2008 Incubation of VSMC with uric acid for 48 h also increased angiotensinogen messenger RNA expression and intracellular concentrations of angiotensin II. Uric Acid 24-33 angiotensinogen Rattus norvegicus 58-73
18192841-6 2008 Incubation of VSMC with uric acid for 48 h also increased angiotensinogen messenger RNA expression and intracellular concentrations of angiotensin II. Uric Acid 24-33 angiotensinogen Rattus norvegicus 135-149
18192841-12 2008 CONCLUSION: These results demonstrate that uric acid stimulates proliferation, angiotensin II production, and oxidative stress in VSMC through tissue RAS. Uric Acid 43-52 angiotensinogen Rattus norvegicus 79-93
18360072-1 2008 Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Uric Acid 100-109 xanthine dehydrogenase Homo sapiens 25-28
18360072-2 2008 Inhibitors of XOR can thus decrease the concentration of uric acid in serum. Uric Acid 57-66 xanthine dehydrogenase Homo sapiens 14-17
17899248-11 2008 Differences in CLPP were largely (94%) associated with the relative utilization of gluconic, malic (greater in nonthinned than thinned soil and mound than furrow soil), L-tartaric, succinic, and uric acids (greater in thinned than nonthinned, mound than furrow, and 5-10 cm than 0-5 cm soil). Uric Acid 195-205 clpP Eucalyptus marginata 15-19
18190810-0 2008 Uric acid determination using uricase and the autotransducer molecular absorption properties of peroxidase. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 30-37
18190810-2 2008 The method as a whole involves UA oxidation in the presence of uricase (UOx), giving H(2)O(2.) Uric Acid 31-33 urate oxidase (pseudogene) Homo sapiens 63-70
18190810-2 2008 The method as a whole involves UA oxidation in the presence of uricase (UOx), giving H(2)O(2.) Uric Acid 31-33 urate oxidase (pseudogene) Homo sapiens 72-75
18082342-0 2008 Uric acid: a surrogate of insulin resistance in older women. Uric Acid 0-9 insulin Homo sapiens 26-33
17905578-9 2008 A layer of nafion is made over PMMA-MWCNT(PDDA)/GOx-NFE that significantly suppressed the electrochemical interference from ascorbic acid or uric acid. Uric Acid 141-150 hydroxyacid oxidase 1 Homo sapiens 48-51
18082342-15 2008 CONCLUSION: A positive association was identified between serum UA and insulin resistance in older women but not in men. Uric Acid 64-66 insulin Homo sapiens 71-78
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 113-118
17826865-5 2008 Unlike most mammals, humans lack the enzyme uricase (urate oxidase) that catalyzes the oxidation of uric acid to a more soluble product. Uric Acid 100-109 urate oxidase (pseudogene) Homo sapiens 44-51
17826865-6 2008 This review describes the development of a poly(ethylene glycol) (PEG) conjugate of recombinant porcine-like uricase with which a substantial and persistent reduction of plasma urate concentrations has been demonstrated in a Phase 2 clinical trial. Uric Acid 177-182 urate oxidase (pseudogene) Homo sapiens 109-116
18179892-8 2008 We discovered association between serum urate and SLC2A9, a glucose transporter (p = 2 x 10(-15)) and confirmed this in two independent cohorts, GRAPHIC study (p = 9 x 10(-15)) and TwinsUK (p = 8 x 10(-19)). Uric Acid 40-45 solute carrier family 2 member 9 Homo sapiens 50-56
18281860-6 2008 Monosodium urate crystals stimulate IL-1beta secretion via cryopyrin, which led to the addition of gout to the spectrum of autoinflammatory diseases. Uric Acid 0-16 interleukin 1 beta Homo sapiens 36-44
18281860-6 2008 Monosodium urate crystals stimulate IL-1beta secretion via cryopyrin, which led to the addition of gout to the spectrum of autoinflammatory diseases. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 59-68
18063857-2 2008 We examined the relationship between intrarenal vessel function and serum UA and its excretion in association with urinary N-acetyl-beta-D-glucosaminidase (NAG). Uric Acid 74-76 O-GlcNAcase Homo sapiens 123-154
18063857-2 2008 We examined the relationship between intrarenal vessel function and serum UA and its excretion in association with urinary N-acetyl-beta-D-glucosaminidase (NAG). Uric Acid 74-76 O-GlcNAcase Homo sapiens 156-159
18227000-5 2008 The defect of renal ammoniogenesis armature by the resistance of the renal cells to insulin involves a urinary hyperacidity which supports the crystallization of the uric acid responsible for the formation of uric or mixed uric acid/oxalate stones. Uric Acid 166-175 insulin Homo sapiens 84-91
18227000-5 2008 The defect of renal ammoniogenesis armature by the resistance of the renal cells to insulin involves a urinary hyperacidity which supports the crystallization of the uric acid responsible for the formation of uric or mixed uric acid/oxalate stones. Uric Acid 223-232 insulin Homo sapiens 84-91
18983690-2 2008 In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Uric Acid 180-185 alpha kinase 2 Homo sapiens 56-59
19509465-9 2008 The preliminary conclusion of our study is that uric acid, the most important salivary antioxidant and GGT could be considered in the future as useful markers of oxidative stress for elaboration of treatment strategy and monitoring. Uric Acid 48-57 gamma-glutamyltransferase 2, pseudogene Homo sapiens 103-106
17761018-0 2008 Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. Uric Acid 20-29 insulin Homo sapiens 115-122
17761018-9 2008 Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Uric Acid 24-26 insulin Homo sapiens 137-144
17761018-9 2008 Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Uric Acid 24-26 insulin Homo sapiens 168-175
17761018-10 2008 Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Uric Acid 52-54 insulin Homo sapiens 101-108
17761018-10 2008 Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Uric Acid 52-54 insulin Homo sapiens 184-191
17761018-12 2008 Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels. Uric Acid 10-12 insulin Homo sapiens 140-147
17761018-12 2008 Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels. Uric Acid 103-105 insulin Homo sapiens 140-147
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 94-103 solute carrier family 22 member 12 Homo sapiens 183-188
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 94-103 potassium two pore domain channel subfamily K member 3 Homo sapiens 190-194
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 94-103 solute carrier family 22 member 8 Homo sapiens 196-200
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 94-103 ATP binding cassette subfamily C member 4 Homo sapiens 205-209
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 113-118
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 155-164 solute carrier family 22 member 12 Homo sapiens 183-188
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 155-164 potassium two pore domain channel subfamily K member 3 Homo sapiens 190-194
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 155-164 solute carrier family 22 member 8 Homo sapiens 196-200
18762713-3 2008 We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro. Uric Acid 155-164 ATP binding cassette subfamily C member 4 Homo sapiens 205-209
18591837-0 2008 Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men. Uric Acid 31-40 adiponectin, C1Q and collagen domain containing Homo sapiens 84-95
18591837-3 2008 In the present study, we investigated the relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men. Uric Acid 73-82 adiponectin, C1Q and collagen domain containing Homo sapiens 126-137
18591837-7 2008 There was significant positive correlation between visceral fat area and serum uric acid levels (r=0.223, p<0.0001), and negative correlation between serum adiponectin concentration and serum uric acid levels (r=-0.198, p<0.0001). Uric Acid 195-204 adiponectin, C1Q and collagen domain containing Homo sapiens 159-170
18591837-9 2008 Stepwise multiple regression analysis showed that VFA and the serum adiponectin concentration were significant explanatory variables for serum uric acid levels. Uric Acid 143-152 adiponectin, C1Q and collagen domain containing Homo sapiens 68-79
19183513-7 2008 In addition, beta-glucuronidase and lactate dehydrogenase level were reduced in withaferin A (100microg/ml) treated monosodium urate crystal-incubated polymorphonuclear leucocytes. Uric Acid 116-132 glucuronidase, beta Mus musculus 13-31
18946224-0 2008 Ambulatory blood pressure, proteinuria and uric acid in children with IgA nephropathy and their correlation with histopathological findings. Uric Acid 43-52 immunoglobulin heavy variable 4-38-2-like Homo sapiens 70-73
19076090-5 2008 Significant negative correlations were found between adiponectin content and BMI (r=-0.36), WC (r=-0.34), index (r=-0.31), level of diastolic arterial pressure (r=-0.34), concentrations of glucose (r=-0.24), insulin (r=-0.26), FFA (r=-0.24), TG (r=-0.45), uric acid (r=-0.29). Uric Acid 256-265 adiponectin, C1Q and collagen domain containing Homo sapiens 53-64
18087170-6 2008 In the IgAN group, hs-CRP showed positive correlations with IgA, uric acid, systolic blood pressure, BMI and age. Uric Acid 65-74 IGAN1 Homo sapiens 7-11
18087170-6 2008 In the IgAN group, hs-CRP showed positive correlations with IgA, uric acid, systolic blood pressure, BMI and age. Uric Acid 65-74 C-reactive protein Homo sapiens 22-25
18946224-3 2008 The aim of the study was to investigate nighttime BP and uric acid in children with IgAN. Uric Acid 57-66 IGAN1 Homo sapiens 84-88
18065272-6 2008 In addition, beta-glucuronidase and lactate dehydrogenase level were reduced in Triphala (100 microg/ml) treated monosodium urate crystal-incubated polymorphonuclear leucocytes. Uric Acid 113-129 glucuronidase, beta Mus musculus 13-31
18067674-1 2007 Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic deficiency. Uric Acid 133-142 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 62-66
18396620-0 2007 [Correlation between serum uric acid and insulin resistance]. Uric Acid 27-36 insulin Homo sapiens 41-48
18396620-1 2007 OBJECTIVE: To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing. Uric Acid 51-60 insulin Homo sapiens 65-72
18396620-6 2007 The prevalence of insulin resistance increased with the elevation of uric acid level, from 13.8% in quartile 1 to 33.9% in quartile 4. Uric Acid 69-78 insulin Homo sapiens 18-25
18396620-9 2007 Uric acid was independently correlated with insulin resistance after adjustment for sex, age and main components of metabolic syndrome (MS). Uric Acid 0-9 insulin Homo sapiens 44-51
18396620-10 2007 CONCLUSION: Serum uric acid is correlated with insulin resistance in Beijing natural population after adjustment of sex, age, and the main components of MS. Uric Acid 18-27 insulin Homo sapiens 47-54
17978310-1 2007 Elevated serum uric acid level is associated with obesity, insulin resistance, diabetes, nephropathy, and hypertension. Uric Acid 15-24 insulin Homo sapiens 59-66
24459503-0 2007 Effects of Increased Uric Acid Intake on the Abundance of Urate-anion exchanger and Organic Anion Transporter Proteins in the Rat Kidney. Uric Acid 21-30 ATP binding cassette subfamily C member 3 Rattus norvegicus 84-109
24459503-1 2007 Renal handling of uric acid mainly occurs in the proximal tubule, and bidirectional transport of urate may involve apical absorption via the urate-anion exchanger (URAT1) and basolateral uptake via organic anion transporters (OAT1 and OAT3). Uric Acid 97-102 solute carrier family 22 member 6 Rattus norvegicus 226-230
24459503-1 2007 Renal handling of uric acid mainly occurs in the proximal tubule, and bidirectional transport of urate may involve apical absorption via the urate-anion exchanger (URAT1) and basolateral uptake via organic anion transporters (OAT1 and OAT3). Uric Acid 97-102 solute carrier family 22 member 8 Rattus norvegicus 235-239
24459503-2 2007 In rat kidneys, we investigated whether the protein abundance of URAT1, OAT1, and OAT3 is affected by the increase in uric acid intake. Uric Acid 118-127 solute carrier family 22 member 8 Rattus norvegicus 82-86
24459503-7 2007 However, OAT1 protein abundance was significantly increased in the uric acid-supplemented rats compared with the control rats. Uric Acid 67-76 solute carrier family 22 member 6 Rattus norvegicus 9-13
24459503-9 2007 In conclusion, OAT1 may have a regulatory role in response to the increase in uric acid intake in the rat kidney. Uric Acid 78-87 solute carrier family 22 member 6 Rattus norvegicus 15-19
24459503-10 2007 The up-regulation of OAT1 would exert stimulation of urinary uric acid excretion and might contribute to protection from hyperuricemia. Uric Acid 61-70 solute carrier family 22 member 6 Rattus norvegicus 21-25
17977705-3 2007 Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. Uric Acid 169-185 NLR family pyrin domain containing 3 Homo sapiens 39-44
17768309-3 2007 Thus, our study systematically analyzed the APOA5 gene for association with lipid parameters, any other features of MetS, including waist circumference, glucose-related parameters, blood pressure, uric acid, and MetS itself in Caucasians. Uric Acid 197-206 apolipoprotein A5 Homo sapiens 44-49
18089325-7 2007 There were significant positive correlations between serum PAPP-A levels and urea (r=.547, P=.001), creatinine (r=.497, P=.001), uric acid (r=.452, P=.001), and CRP values (r=.387, P=.001). Uric Acid 129-138 pappalysin 1 Homo sapiens 59-65
17714972-11 2007 Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 60-65
17714972-11 2007 Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response. Uric Acid 0-5 interleukin 1 beta Homo sapiens 104-112
17855651-1 2007 Expression of Urate transporter 1 (URAT1/SLC22A12) is restricted to the proximal tubules in the kidney, where it is responsible for the tubular reabsorption of urate. Uric Acid 160-165 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 35-40
17855651-1 2007 Expression of Urate transporter 1 (URAT1/SLC22A12) is restricted to the proximal tubules in the kidney, where it is responsible for the tubular reabsorption of urate. Uric Acid 160-165 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 41-49
18089325-9 2007 CONCLUSION: We concluded that PAPP-A level was elevated in renal transplant patients and that high levels of PAPP-A might be a prognostic marker owing to their close association with high serum levels of urea, creatinine, uric acid, and CRP. Uric Acid 222-231 pappalysin 1 Homo sapiens 109-115
17719217-8 2007 The electrocatalytic activity of the MPx-11 electrode is combined with the enzymatic activity of uricase (UOx) to fabricate uric acid biosensor. Uric Acid 124-133 urate oxidase (pseudogene) Homo sapiens 106-109
18021608-8 2007 In the multivariate analysis, low GFR was independently related to advanced age (odds ratio [OR] between 1.30 y 4.20), female gender (OR = 5.82), HT older than 7 years (OR = 1.23), uric acid (OR = 1.52 for each increment of 1 mg/dl) and cardiovascular disease (OR = 1.68). Uric Acid 181-190 Rap guanine nucleotide exchange factor 5 Homo sapiens 34-37
18021608-12 2007 The variables directly associated with low GFR were advanced age, female gender, HT of longer evolution, cardiovascular disease, increased uric acid, and, in one model, DM. Uric Acid 139-148 Rap guanine nucleotide exchange factor 5 Homo sapiens 43-46
17996131-0 2007 [Association of endothelial nitric oxide synthase gene polymorphism with level of uric acid in serum for acute coronary syndrome]. Uric Acid 82-91 nitric oxide synthase 3 Homo sapiens 16-49
17997608-0 2007 The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. Uric Acid 40-49 solute carrier family 2 member 9 Homo sapiens 4-9
17997608-6 2007 Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Uric Acid 84-93 solute carrier family 2 member 9 Homo sapiens 42-47
17997608-6 2007 Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Uric Acid 149-158 solute carrier family 2 member 9 Homo sapiens 42-47
17726077-11 2007 Plasma RBP and PCI were not significantly related to M. RBP was positively correlated with uric acid (r = 0.488, P = 0.003), triglycerides (r = 0.592, P < 0.001), prealbumin (r = 0.63, P < 0.0001), and vitamin A (r = 0.75, P < 10(-6)). Uric Acid 91-100 retinol binding protein 4 Homo sapiens 56-59
17891408-5 2007 As a result of a case-control study on individuals with normal and reduced renal uric acid excretion, an association of polymorphisms in the human urate transporter 1 gene (hURAT1) with primary reduced urate excretion has been demonstrated for the first time. Uric Acid 81-90 solute carrier family 22 member 12 Homo sapiens 147-166
17891408-5 2007 As a result of a case-control study on individuals with normal and reduced renal uric acid excretion, an association of polymorphisms in the human urate transporter 1 gene (hURAT1) with primary reduced urate excretion has been demonstrated for the first time. Uric Acid 81-90 solute carrier family 22 member 12 Homo sapiens 173-179
17891408-7 2007 Functioning as an antiporter, hURAT1 mediates the uptake of urate from the lumen into proximal tubule cells in exchange for organic and inorganic anions. Uric Acid 60-65 solute carrier family 22 member 12 Homo sapiens 30-36
17891408-9 2007 The precisely regulated hURAT1 is a candidate gene for hyperuricemia and an important target for the development and optimization of new diagnostic approaches and pharmacological interventions of primary reduced renal uric acid excretion. Uric Acid 218-227 solute carrier family 22 member 12 Homo sapiens 24-30
17996131-1 2007 OBJECTIVE: To evaluate the association of elevation in serum uric acid with the development of coronary artery disease, and to determine the relationship between uric acid and Glu(298) Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene in acute coronary syndrome (ACS) in the Chinese Han Nationality. Uric Acid 162-171 nitric oxide synthase 3 Homo sapiens 209-242
17996131-7 2007 CONCLUSION: Glu(298) Asp polymorphism of the eNOS gene appears to have no association with ACS in the Chinese Han Nationality, but a significant association between the eNOS Glu(298) Asp variant and the serum uric acid level is found in patients with ACS. Uric Acid 209-218 nitric oxide synthase 3 Homo sapiens 45-49
17996131-7 2007 CONCLUSION: Glu(298) Asp polymorphism of the eNOS gene appears to have no association with ACS in the Chinese Han Nationality, but a significant association between the eNOS Glu(298) Asp variant and the serum uric acid level is found in patients with ACS. Uric Acid 209-218 nitric oxide synthase 3 Homo sapiens 169-173
18218233-0 2007 [A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance]. Uric Acid 51-60 insulin Homo sapiens 69-76
18218233-0 2007 [A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance]. Uric Acid 51-60 insulin Homo sapiens 93-100
18218233-1 2007 OBJECTIVE: To assess the effect of the serum uric acid (UA) on insulin resistance (IR). Uric Acid 45-54 insulin Homo sapiens 63-70
18218233-1 2007 OBJECTIVE: To assess the effect of the serum uric acid (UA) on insulin resistance (IR). Uric Acid 56-58 insulin Homo sapiens 63-70
17701896-7 2007 The loss-of-function mutations of PRPS1 likely result in impaired purine biosynthesis, which is supported by the undetectable hypoxanthine in urine and the reduced uric acid levels in serum from patients. Uric Acid 164-173 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 34-39
17721747-0 2007 Serum uric acid shows a J-shaped trend with coronary mortality in non-insulin-dependent diabetic elderly people. Uric Acid 6-15 insulin Homo sapiens 70-77
17825714-11 2007 Growth differentiation factor 15 provided prognostic information in clinically relevant patient subgroups (defined according to age, body mass index, heart failure etiology, concomitant medical therapy, renal function, and the levels of hemoglobin and uric acid) and added prognostic information to NYHA functional class, LVEF, and NT-proBNP. Uric Acid 252-261 growth differentiation factor 15 Homo sapiens 0-32
17535983-10 2007 Furthermore, MSU crystals induce the formation of a complex containing p85 and Syk, which is mediated by the Src family kinases. Uric Acid 13-16 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 71-74
23496132-4 2007 The recent identification of the renal apical urate/anion exchanger URAT1 (SLC22A12) and several membrane proteins relevant to the transport of urate play an important role in gaining a better understanding of the mode of action of many drugs used to treat gout. Uric Acid 46-51 solute carrier family 22 member 12 Homo sapiens 68-73
23496132-4 2007 The recent identification of the renal apical urate/anion exchanger URAT1 (SLC22A12) and several membrane proteins relevant to the transport of urate play an important role in gaining a better understanding of the mode of action of many drugs used to treat gout. Uric Acid 46-51 solute carrier family 22 member 12 Homo sapiens 75-83
17535983-10 2007 Furthermore, MSU crystals induce the formation of a complex containing p85 and Syk, which is mediated by the Src family kinases. Uric Acid 13-16 spleen associated tyrosine kinase Homo sapiens 79-82
17442855-4 2007 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. Uric Acid 157-166 NLR family pyrin domain containing 3 Homo sapiens 0-9
17428837-7 2007 The stimulation of NADPH oxidase-dependent ROS by uric acid resulted in activation of MAP kinases p38 and ERK1/2, a decrease in nitric oxide bioavailability, and an increase in protein nitrosylation and lipid oxidation. Uric Acid 50-59 mitogen-activated protein kinase 1 Homo sapiens 98-101
17428837-7 2007 The stimulation of NADPH oxidase-dependent ROS by uric acid resulted in activation of MAP kinases p38 and ERK1/2, a decrease in nitric oxide bioavailability, and an increase in protein nitrosylation and lipid oxidation. Uric Acid 50-59 mitogen-activated protein kinase 3 Homo sapiens 106-112
17666819-8 2007 It seems to be likely that these flavonoids reduce serum urate levels by mainly inhibiting XOD activity. Uric Acid 57-62 xanthine dehydrogenase Mus musculus 91-94
17660342-0 2007 Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid. Uric Acid 108-117 solute carrier family 22 member 12 Homo sapiens 38-46
17442855-4 2007 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. Uric Acid 157-166 NLR family pyrin domain containing 3 Homo sapiens 10-15
17442855-4 2007 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. Uric Acid 157-166 caspase 1 Homo sapiens 25-34
17631100-3 2007 The nano-Au/PPyox/GCE had strongly catalytic activity toward the oxidation of epinephrine (EP), uric acid (UA) and ascorbic acid (AA), and resolved the overlapping voltammetric response of EP, UA and AA into three well-defined peaks with a large anodic peak difference. Uric Acid 96-105 aminomethyltransferase Homo sapiens 18-21
17631100-3 2007 The nano-Au/PPyox/GCE had strongly catalytic activity toward the oxidation of epinephrine (EP), uric acid (UA) and ascorbic acid (AA), and resolved the overlapping voltammetric response of EP, UA and AA into three well-defined peaks with a large anodic peak difference. Uric Acid 107-109 aminomethyltransferase Homo sapiens 18-21
17631100-3 2007 The nano-Au/PPyox/GCE had strongly catalytic activity toward the oxidation of epinephrine (EP), uric acid (UA) and ascorbic acid (AA), and resolved the overlapping voltammetric response of EP, UA and AA into three well-defined peaks with a large anodic peak difference. Uric Acid 193-195 aminomethyltransferase Homo sapiens 18-21
17631100-7 2007 The nano-Au/PPyox/GCE has been applied to determination of EP in epinephrine hydrochloride injection and UA in urine samples with satisfactory results. Uric Acid 105-107 aminomethyltransferase Homo sapiens 18-21
17010581-7 2007 Univariate and multivariate analysis showed that 5,10-methylenetetrahydrofolate reductase (C677T) polymorphism was a strong correlate and predictor of uric acid in males (r=0.28, p=0.0001, beta=0.673, p=<0.001) and in females (r=0.27, p=0.0001, beta=0.599, p=<0.001). Uric Acid 151-160 methylenetetrahydrofolate reductase Homo sapiens 54-89
17599452-0 2007 Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Uric Acid 14-23 C-reactive protein Homo sapiens 46-64
17599452-0 2007 Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Uric Acid 14-23 interleukin 6 Homo sapiens 69-82
17599452-3 2007 Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Uric Acid 27-29 C-reactive protein Homo sapiens 72-90
17599452-3 2007 Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Uric Acid 27-29 C-reactive protein Homo sapiens 92-95
17599452-3 2007 Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Uric Acid 45-47 C-reactive protein Homo sapiens 72-90
17599452-3 2007 Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Uric Acid 45-47 C-reactive protein Homo sapiens 92-95
17599452-7 2007 The relation between UA and CRP persisted after adjustment for baseline IL-6. Uric Acid 21-23 C-reactive protein Homo sapiens 28-31
17599452-7 2007 The relation between UA and CRP persisted after adjustment for baseline IL-6. Uric Acid 21-23 interleukin 6 Homo sapiens 72-76
17599452-8 2007 Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. Uric Acid 19-21 interleukin 6 Homo sapiens 117-121
17599452-8 2007 Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. Uric Acid 19-21 C-reactive protein Homo sapiens 142-145
17605604-1 2007 OBJECTIVE: To examine the ability of preemptive administration of a proprietary neurokinin-1 (NK(1)) receptor antagonist to attenuate limb dysfunction associated with monosodium urate-induced synovitis in the stifle joints of dogs. Uric Acid 167-183 tachykinin receptor 1 Canis lupus familiaris 80-109
17599072-2 2007 DAMP molecules, including high mobility group box 1 protein (HMGB-1), heat-shock proteins (HSPs), uric acid, altered matrix proteins, and S100 proteins, represent important danger signals that mediate inflammatory responses through the receptor for advanced glycation end-products (RAGE, also known as AGER) and Toll-like receptors, after release from activated or necrotic cells. Uric Acid 98-107 advanced glycosylation end-product specific receptor Homo sapiens 236-280
17010581-9 2007 CONCLUSION: Results from this study suggest that mutation of 5-MTHFR C677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia. Uric Acid 101-110 methylenetetrahydrofolate reductase Homo sapiens 63-68
17525395-1 2007 BACKGROUND AND PURPOSE: Uric acid (UA) increases the neuroprotective effects of recombinant tissue plasminogen activator (rt-PA) in experimental ischemia. Uric Acid 35-37 chromosome 20 open reading frame 181 Homo sapiens 92-120
17221363-10 2007 Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Uric Acid 167-176 interleukin 1 beta Homo sapiens 17-26
17525395-1 2007 BACKGROUND AND PURPOSE: Uric acid (UA) increases the neuroprotective effects of recombinant tissue plasminogen activator (rt-PA) in experimental ischemia. Uric Acid 24-33 chromosome 20 open reading frame 181 Homo sapiens 92-120
17221363-10 2007 Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Uric Acid 167-176 tumor necrosis factor Homo sapiens 28-37
17221363-10 2007 Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Uric Acid 167-176 C-C motif chemokine ligand 2 Homo sapiens 42-47
17325024-0 2007 Morin (3,5,7,2",4"-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Uric Acid 78-83 solute carrier family 22 member 12 Homo sapiens 132-138
17562056-4 2007 With the first episode of often typical (red, hot, exquisitely painful first MTP joint) acute arthritis or with urate nephrolithiasis, increased uric acid turns pathological. Uric Acid 145-154 alcohol dehydrogenase iron containing 1 Homo sapiens 46-49
17562056-4 2007 With the first episode of often typical (red, hot, exquisitely painful first MTP joint) acute arthritis or with urate nephrolithiasis, increased uric acid turns pathological. Uric Acid 145-154 metallothionein 1B Homo sapiens 77-80
17512306-2 2007 In addition, this study explores the relationship between UA and insulin resistance and serum leptin levels in metabolic syndrome. Uric Acid 58-60 insulin Homo sapiens 65-72
17512306-2 2007 In addition, this study explores the relationship between UA and insulin resistance and serum leptin levels in metabolic syndrome. Uric Acid 58-60 leptin Homo sapiens 94-100
17512306-12 2007 Uric acid appeared to be better correlated with Tg, blood pressure (both systolic and diastolic), obesity, immunoreactive insulin, and HOMA-IR. Uric Acid 0-9 insulin Homo sapiens 122-129
17289413-6 2007 The plasma levels of glucose, urate and total amino acid were significantly elevated by CORT treatment. Uric Acid 30-35 CORT Gallus gallus 88-92
17456983-6 2007 Patients with high cTnT had abnormally high blood concentrations of BNP (p<0.0001), ICTP (p<0.0001), PIIIP (p=0.0006), NOREPI (p=0.0119), CRP (p=0.0003), uric acid (p=0.0026) and HbA1c (p=0.0361). Uric Acid 160-169 troponin T2, cardiac type Homo sapiens 19-23
17395009-5 2007 When MnSOD was exposed to J*NO and JO(2)(*-) in the presence of uric acid, a scavenger of peroxynitrite-derived free radicals, nitration was decreased but inactivation was not prevented. Uric Acid 64-73 superoxide dismutase 2 Homo sapiens 5-10
17409311-1 2007 Sodium-hydrogen exchanger regulatory factor-1-deficient (NHERF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid associated with interstitial deposition of calcium in the papilla of the kidney. Uric Acid 150-159 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 0-45
17409311-1 2007 Sodium-hydrogen exchanger regulatory factor-1-deficient (NHERF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid associated with interstitial deposition of calcium in the papilla of the kidney. Uric Acid 150-159 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 57-64
17409311-2 2007 These studies examine the role of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate transporter 1 (mURAT1), a newly described transporter that is responsible for the renal tubular reabsorption of uric acid. Uric Acid 73-82 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 34-41
17409311-2 2007 These studies examine the role of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate transporter 1 (mURAT1), a newly described transporter that is responsible for the renal tubular reabsorption of uric acid. Uric Acid 225-234 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 128-134
17409311-3 2007 In primary cultures of mouse renal proximal tubule cells, uric acid uptake was significantly lower in NHERF-1(-/-) cells compared with wild-type cells over a large range of uric acid concentrations in the media. Uric Acid 58-67 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 102-109
17409311-3 2007 In primary cultures of mouse renal proximal tubule cells, uric acid uptake was significantly lower in NHERF-1(-/-) cells compared with wild-type cells over a large range of uric acid concentrations in the media. Uric Acid 173-182 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 102-109
17409311-7 2007 Infection of NHERF-1(-/-) cells with adenovirus-green fluorescence protein-NHERF-1 resulted in significantly higher rates of uric acid transport (15.4 +/- 1.1 pmol/microg protein per 30 min) compared with null cells that were infected with control adenovirus-green fluorescence protein (7.9 +/- 0.3) and restoration of the inhibitory effect of para-aminohippurate (% inhibition 34 +/- 4%). Uric Acid 125-134 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 13-20
17409311-7 2007 Infection of NHERF-1(-/-) cells with adenovirus-green fluorescence protein-NHERF-1 resulted in significantly higher rates of uric acid transport (15.4 +/- 1.1 pmol/microg protein per 30 min) compared with null cells that were infected with control adenovirus-green fluorescence protein (7.9 +/- 0.3) and restoration of the inhibitory effect of para-aminohippurate (% inhibition 34 +/- 4%). Uric Acid 125-134 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 75-82
17409311-8 2007 These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters. Uric Acid 102-111 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 29-36
17409311-8 2007 These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters. Uric Acid 102-111 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 160-166
17552288-6 2007 Multiple logistic regression analysis showed that insulin resistance as evaluated by fasting insulin, sigma insulin during OGTT, HOMA-IR, insulin sensitivity index, the levels of uric acid, fasting glucose, systolic blood pressure and maximal oxygen uptake were independently associated with ST segment depression. Uric Acid 179-188 insulin Homo sapiens 50-57
17117187-11 2007 Uric acid was significantly inversely related to adiponectin in women only (sex interaction: P=0.02). Uric Acid 0-9 adiponectin, C1Q and collagen domain containing Homo sapiens 49-60
17409311-0 2007 Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. Uric Acid 121-130 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 0-45
17445548-3 2007 In adult humans, we independently measured the (13)C enrichment of the C(2) and C(8) positions of urinary uric acid after an oral dose of [(13)C]sodium formate and that of the C(2) and C(8) plus C(5) positions after [2-(13)C]glycine. Uric Acid 106-115 complement C2 Homo sapiens 71-75
17445548-3 2007 In adult humans, we independently measured the (13)C enrichment of the C(2) and C(8) positions of urinary uric acid after an oral dose of [(13)C]sodium formate and that of the C(2) and C(8) plus C(5) positions after [2-(13)C]glycine. Uric Acid 106-115 homeobox C8 Homo sapiens 80-84
17203476-7 2007 Our results also suggest that glia provide EAAT-1 and EAAT-2 glutamate transporters to protect neurons from glutamate, that functional EAATs may be necessary to mediate the effects of UA, and that treatment with UA results in upregulation of EAAT-1 protein. Uric Acid 212-214 solute carrier family 1 member 3 Rattus norvegicus 43-49
16963150-2 2007 The relationship between UA and fasting plasma glucose (FPG) and 2-h plasma glucose concentrations in non-diabetic subjects as well as in diabetic subjects in general population is not well known. Uric Acid 25-27 nei like DNA glycosylase 3 Homo sapiens 40-66
17203476-7 2007 Our results also suggest that glia provide EAAT-1 and EAAT-2 glutamate transporters to protect neurons from glutamate, that functional EAATs may be necessary to mediate the effects of UA, and that treatment with UA results in upregulation of EAAT-1 protein. Uric Acid 212-214 solute carrier family 1 member 2 Rattus norvegicus 54-60
17203476-7 2007 Our results also suggest that glia provide EAAT-1 and EAAT-2 glutamate transporters to protect neurons from glutamate, that functional EAATs may be necessary to mediate the effects of UA, and that treatment with UA results in upregulation of EAAT-1 protein. Uric Acid 212-214 solute carrier family 1 member 3 Rattus norvegicus 242-248
17386751-1 2007 A novel amperometric uric acid (UA) sensor has been developed by coating the surface of a gold electrode with a polystyrene (PS) membrane formed by 30 microL of a 30 mg mL(-1) PS chloroform solution combined with 30 microL of a 5 mg mL(-1) polymaleimidostyrene (PMS) solution as a dispersant for enzyme, uricase; this membrane has been successfully employed as an immobilization support for uricase. Uric Acid 21-30 urate oxidase (pseudogene) Homo sapiens 391-398
17386751-1 2007 A novel amperometric uric acid (UA) sensor has been developed by coating the surface of a gold electrode with a polystyrene (PS) membrane formed by 30 microL of a 30 mg mL(-1) PS chloroform solution combined with 30 microL of a 5 mg mL(-1) polymaleimidostyrene (PMS) solution as a dispersant for enzyme, uricase; this membrane has been successfully employed as an immobilization support for uricase. Uric Acid 32-34 urate oxidase (pseudogene) Homo sapiens 304-311
17386751-0 2007 Immobilization of uricase within polystyrene using polymaleimidostyrene as a stabilizer and its application to uric acid sensor. Uric Acid 111-120 urate oxidase (pseudogene) Homo sapiens 18-25
17386751-1 2007 A novel amperometric uric acid (UA) sensor has been developed by coating the surface of a gold electrode with a polystyrene (PS) membrane formed by 30 microL of a 30 mg mL(-1) PS chloroform solution combined with 30 microL of a 5 mg mL(-1) polymaleimidostyrene (PMS) solution as a dispersant for enzyme, uricase; this membrane has been successfully employed as an immobilization support for uricase. Uric Acid 32-34 urate oxidase (pseudogene) Homo sapiens 391-398
17386751-1 2007 A novel amperometric uric acid (UA) sensor has been developed by coating the surface of a gold electrode with a polystyrene (PS) membrane formed by 30 microL of a 30 mg mL(-1) PS chloroform solution combined with 30 microL of a 5 mg mL(-1) polymaleimidostyrene (PMS) solution as a dispersant for enzyme, uricase; this membrane has been successfully employed as an immobilization support for uricase. Uric Acid 21-30 urate oxidase (pseudogene) Homo sapiens 304-311
17278929-6 2007 Two laboratories have documented interesting findings that Toll-like receptor-mediated pathways or MyD88-dependent pathways are involved in monosodium urate monohydrate crystal-induced acute inflammation. Uric Acid 140-168 MYD88 innate immune signal transduction adaptor Homo sapiens 99-104
17023154-0 2007 Development and analytical application of an uric acid biosensor using an uricase-immobilized eggshell membrane. Uric Acid 45-54 urate oxidase (pseudogene) Homo sapiens 74-81
17023154-1 2007 An uric acid biosensor fabricated from a uricase-immobilized eggshell membrane and an oxygen electrode was presented. Uric Acid 3-12 urate oxidase (pseudogene) Homo sapiens 41-48
17023154-2 2007 The detection schemes involve the enzymatic reactions of the uricase leading to the depletion of dissolved oxygen level upon exposure to uric acid solution. Uric Acid 137-146 urate oxidase (pseudogene) Homo sapiens 61-68
17278929-7 2007 Upregulation of the triggering receptor expressed on myeloid cells 1 (TREM-1) in phagocytes by the stimulation with monosodium urate monohydrate crystals has been demonstrated. Uric Acid 116-144 triggering receptor expressed on myeloid cells 1 Homo sapiens 20-68
17278929-7 2007 Upregulation of the triggering receptor expressed on myeloid cells 1 (TREM-1) in phagocytes by the stimulation with monosodium urate monohydrate crystals has been demonstrated. Uric Acid 116-144 triggering receptor expressed on myeloid cells 1 Homo sapiens 70-76
17278930-2 2007 RECENT FINDINGS: Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. Uric Acid 65-70 solute carrier family 22 member 12 Homo sapiens 87-92
17278930-2 2007 RECENT FINDINGS: Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. Uric Acid 65-70 solute carrier family 22 member 12 Homo sapiens 94-102
18651469-7 2007 Leptin levels correlated positively with all anthropometric measurements, fasting glucose, triglyceride levels, CRP and uric acid and negatively with HDL-cholesterol. Uric Acid 120-129 leptin Homo sapiens 0-6
17297168-8 2007 Plasma concentrations of glucose and urate were significantly increased by acute CORT administration, whereas the lactic acid was not changed. Uric Acid 37-42 CORT Gallus gallus 81-85
17006547-5 2007 The G6PT(-/-) mice receiving gene therapy exhibit improved growth; normalized serum profiles for glucose, cholesterol, triglyceride, uric acid and lactic acid; and reduced hepatic glycogen deposition. Uric Acid 133-142 solute carrier family 37 (glucose-6-phosphate transporter), member 4 Mus musculus 4-8
16985215-0 2007 Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-kappaB. Uric Acid 0-9 phospholipase A2 group IVA Homo sapiens 117-122
16985215-0 2007 Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-kappaB. Uric Acid 0-9 nuclear factor kappa B subunit 1 Homo sapiens 128-137
16985215-4 2007 The uric acid induced p38 MAPK phosphorylation was also blocked by H-7 (a PKC inhibitor), indicating that p38 MAPK was a downstream target of PKC. Uric Acid 4-13 mitogen-activated protein kinase 14 Homo sapiens 22-25
16985215-4 2007 The uric acid induced p38 MAPK phosphorylation was also blocked by H-7 (a PKC inhibitor), indicating that p38 MAPK was a downstream target of PKC. Uric Acid 4-13 mitogen-activated protein kinase 14 Homo sapiens 106-109
16985215-6 2007 Evidence of a uric acid-induced activation of NF-kappaB as well as PLA(2) was obtained. Uric Acid 14-23 nuclear factor kappa B subunit 1 Homo sapiens 46-55
16985215-7 2007 Moreover the uric acid-induced inhibition of [(3)H]thymidine incorporation was also blocked by two NF-kappaB inhibitors, pyrrolidine dithiocarbamate and SN 50. Uric Acid 13-22 nuclear factor kappa B subunit 1 Homo sapiens 99-108
16985215-9 2007 Thus the inhibition of [(3)H]thymidine incorporation caused by uric acid can be explained by two distinct mechanisms, the activation of NF-kappaB as well as the activation of PLA(2). Uric Acid 63-72 nuclear factor kappa B subunit 1 Homo sapiens 136-145
17922673-3 2007 This review focuses on (1) previously unknown biological roles of uric acid; (2) why the loss of the uricase gene and resultant hyperuricemia may have provided an evolutionary advantage to primates and, in particular, to humans; (3) the molecular effects of uric acid on inflammatory cells; and (4) novel antihyperuricemic agents currently under study. Uric Acid 66-75 urate oxidase (pseudogene) Homo sapiens 101-108
17922673-3 2007 This review focuses on (1) previously unknown biological roles of uric acid; (2) why the loss of the uricase gene and resultant hyperuricemia may have provided an evolutionary advantage to primates and, in particular, to humans; (3) the molecular effects of uric acid on inflammatory cells; and (4) novel antihyperuricemic agents currently under study. Uric Acid 258-267 urate oxidase (pseudogene) Homo sapiens 101-108
18651432-6 2007 Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Uric Acid 201-210 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11
17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Uric Acid 129-138 C-C motif chemokine ligand 2 Homo sapiens 13-18
17373740-9 2007 Compared with control groups, in mice treated with uric acid and HBsAg-pulsed-DCs, the spleen T cell proliferation to HBsAg re-stimulation was stronger (1.34 +/- 0.093 vs 1.081 +/- 0.028, P < 0.01), the level of IFN-gamma secreted by splenocytes was higher (266.575 +/- 51.323 vs 135.223 +/- 32.563, P < 0.01) , and IL-4 level was lower (22.385 +/- 2.252 vs 40.598 +/- 4.218, P < 0.01). Uric Acid 51-60 interferon gamma Mus musculus 215-224
17373740-9 2007 Compared with control groups, in mice treated with uric acid and HBsAg-pulsed-DCs, the spleen T cell proliferation to HBsAg re-stimulation was stronger (1.34 +/- 0.093 vs 1.081 +/- 0.028, P < 0.01), the level of IFN-gamma secreted by splenocytes was higher (266.575 +/- 51.323 vs 135.223 +/- 32.563, P < 0.01) , and IL-4 level was lower (22.385 +/- 2.252 vs 40.598 +/- 4.218, P < 0.01). Uric Acid 51-60 interleukin 4 Mus musculus 322-326
17138940-7 2007 The nitration inhibitor uric acid or the peroxynitrite decomposition catalyst FeTPPS abolished AngII-induced cerebrovascular nitration and prevented the cerebrovascular effects of AngII. Uric Acid 24-33 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 95-100
17138940-7 2007 The nitration inhibitor uric acid or the peroxynitrite decomposition catalyst FeTPPS abolished AngII-induced cerebrovascular nitration and prevented the cerebrovascular effects of AngII. Uric Acid 24-33 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 180-185
16759717-5 2007 RESULTS: In unadjusted analyses, CRP was positively correlated with age, male gender, body mass index, blood pressure, smoking habit, creatinine, uric acid, triglycerides, an index of insulin resistance, and 8-isoprostane, and inversely correlated with high-density lipoprotein-cholesterol. Uric Acid 146-155 C-reactive protein Homo sapiens 33-36
17352828-1 2007 Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. Uric Acid 0-16 interleukin 1 beta Homo sapiens 73-81
17352828-1 2007 Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 94-99
17352828-3 2007 The effectiveness of IL-1 inhibition was first evaluated in a mouse model of monosodium urate crystal-induced inflammation. Uric Acid 77-93 interleukin 1 complex Mus musculus 21-25
17917440-4 2007 The highest level of uric acid was observed in those with CD4 counts of <200 cells/microl. Uric Acid 21-30 CD4 molecule Homo sapiens 58-61
17894858-12 2007 Endothelial cells exposed to the exosomes underwent apoptosis and caspase-3 activation, which were inhibited by NO synthase inhibitors or by a superoxide dismutase mimetic and totally blocked by urate (1 mM), suggesting a role for the peroxynitrite radical. Uric Acid 195-200 caspase 3 Homo sapiens 66-75
17917440-6 2007 Only uric acid and Zn showed significant correlation with CD4 count. Uric Acid 5-14 CD4 molecule Homo sapiens 58-61
17643063-2 2007 Recently, uric acid crystals (monosodium urate, MSU) from necrotic cell lysates were identified as a danger signal for dendritic cells (DCs). Uric Acid 10-19 male sterility and urinary obstruction Mus musculus 48-51
17385437-1 2007 The relationship of the values of serum apolipoproteins and uric acid (UA) was studied in healthy individuals and patients with cardiovascular diseases. Uric Acid 60-69 apolipoprotein E Homo sapiens 40-55
17385437-1 2007 The relationship of the values of serum apolipoproteins and uric acid (UA) was studied in healthy individuals and patients with cardiovascular diseases. Uric Acid 71-73 apolipoprotein E Homo sapiens 40-55
16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. Uric Acid 11-16 solute carrier family 22 member 6 Homo sapiens 174-201
17891652-4 2007 This study was undertaken to elucidate whether SLC22A12 gene mutations are responsible for low serum uric acid levels in Greek people. Uric Acid 101-110 solute carrier family 22 member 12 Homo sapiens 47-55
17157176-1 2006 A commentary on "Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: Sparing effects of chlorogenic acid and serum albumin". Uric Acid 26-35 albumin Homo sapiens 181-189
17157178-0 2006 Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: sparing effects of chlorogenic acid and serum albumin. Uric Acid 9-18 albumin Homo sapiens 158-171
17157178-5 2006 Both chlorogenic acid and bovine serum albumin, representative of a phenol- and a protein-rich meal, respectively, were able to spare uric acid, although chlorogenic acid increased, whereas bovine serum albumin inhibited, *NO release. Uric Acid 134-143 albumin Homo sapiens 33-46
18220032-1 2007 AIM: To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia. Uric Acid 55-64 apolipoprotein E Homo sapiens 69-74
18220032-4 2007 A comparative correlation analysis detected a significant correlation between uric acid levels and apo-E in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative. Uric Acid 78-87 apolipoprotein E Homo sapiens 99-104
18220032-5 2007 CONCLUSION: Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apo-E and apo-C3. Uric Acid 83-92 apolipoprotein C3 Homo sapiens 104-110
16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. Uric Acid 11-16 solute carrier family 22 member 6 Homo sapiens 203-207
16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. Uric Acid 11-16 solute carrier family 22 member 8 Homo sapiens 213-217
16959942-5 2006 Systemic treatment of mice with [d-Trp(8)]-gamma-MSH inhibited KC release and polymorphonuclear cell accumulation elicited by urate crystals in the murine peritoneal cavity. Uric Acid 126-131 pro-opiomelanocortin-alpha Mus musculus 43-52
17077300-4 2006 Finally, in a model of gouty arthritis, direct injection of urate crystals into the rat joint provoked a marked inflammatory reaction that was significantly inhibited (approximately 70%) by systemic or local administration of [D-Trp8]-gamma-MSH. Uric Acid 60-65 pro-opiomelanocortin-alpha Mus musculus 235-244
17129404-1 2006 Recently three proteins, playing central roles in the bidirectional transport of urate in renal proximal tubules, were identified: two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein that designated renal urate-anion exchanger (URAT1). Uric Acid 81-86 solute carrier family 22 member 6 Homo sapiens 190-194
17129404-1 2006 Recently three proteins, playing central roles in the bidirectional transport of urate in renal proximal tubules, were identified: two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein that designated renal urate-anion exchanger (URAT1). Uric Acid 81-86 solute carrier family 22 member 8 Homo sapiens 199-203
17129404-1 2006 Recently three proteins, playing central roles in the bidirectional transport of urate in renal proximal tubules, were identified: two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein that designated renal urate-anion exchanger (URAT1). Uric Acid 81-86 solute carrier family 22 member 12 Homo sapiens 264-269
16920156-2 2006 URAT1 (coded by SLC22CA12) was recently proposed to be the major absorptive urate transporter protein in the kidney regulating blood urate levels. Uric Acid 76-81 solute carrier family 22 member 12 Homo sapiens 0-5
16920156-3 2006 Because genetic background is known to affect serum urate levels, we hypothesized that genetic variations in SLC22A12 may predispose humans to hyperuricemia and gout. Uric Acid 52-57 solute carrier family 22 member 12 Homo sapiens 109-117
16979382-8 2006 Serum DS-TNFR2 concentration was significantly associated with LDL cholesterol (r=-0.28, p=0.002), uric acid (r=-0.13, p=0.04) and with blood glycated hemoglobin (r=-0.13, p=0.04). Uric Acid 99-108 TNF receptor superfamily member 1B Homo sapiens 9-14
17126770-8 2006 Interestingly, the exercise-induced changes in ICAM-1 and P-selectin levels remained significant after adjustment for the percent variations of body weight, waist circumference, haemoglobin A1c, HDL cholesterol and uric acid concentrations. Uric Acid 215-224 intercellular adhesion molecule 1 Homo sapiens 47-53
17126770-8 2006 Interestingly, the exercise-induced changes in ICAM-1 and P-selectin levels remained significant after adjustment for the percent variations of body weight, waist circumference, haemoglobin A1c, HDL cholesterol and uric acid concentrations. Uric Acid 215-224 selectin P Homo sapiens 58-68
17059995-8 2006 Moreover, uric acid levels correlated positively with levels of triglycerides, phosphate, C-reactive protein, and intracellular adhesion molecule 1 and negatively with levels of calcium, high-density lipoprotein cholesterol, and apolipoprotein A. Uric Acid 10-19 C-reactive protein Homo sapiens 90-147
17059995-8 2006 Moreover, uric acid levels correlated positively with levels of triglycerides, phosphate, C-reactive protein, and intracellular adhesion molecule 1 and negatively with levels of calcium, high-density lipoprotein cholesterol, and apolipoprotein A. Uric Acid 10-19 lipoprotein(a) Homo sapiens 229-245
16820145-6 2006 RESULTS: Among the atherosclerotic risk factors measured, age, pulse pressure, hemoglobin A1c (HbA1c), uric acid, fibrinogen, sialic acid and Lp(a) showed significant positive correlations with aortic pulse wave velocity. Uric Acid 103-112 lipoprotein(a) Homo sapiens 142-147
16820145-8 2006 The correlation between Lp(a) and aortic pulse wave velocity was independent of age, sex, blood hemoglobin A1c, uric acid and fibrinogen, history of diabetic nephropathy and therapy with lipid-lowering drugs. Uric Acid 112-121 lipoprotein(a) Homo sapiens 24-29
17056568-0 2006 Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. Uric Acid 58-74 CD14 antigen Mus musculus 14-18
16861244-0 2006 Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis? Uric Acid 27-36 uromodulin Homo sapiens 5-26
18404470-3 2006 It has been proposed that cN-II regulates the intracellular concentration of IMP and GMP and the production of uric acid. Uric Acid 111-120 5'-nucleotidase, cytosolic II Homo sapiens 26-31
17027827-6 2006 Logistic regression analysis of serum uric acid for MS disclosed for the top versus the bottom tertile an odds ratio (OR) of 1.89 (95% confidence interval [CI]: 1.45-2.46) in men and women combined, after adjustment for sex, age, TC, log CRP, log GGT, alcohol, and diuretic drug use, presence of diabetes/impaired fasting glucose, elevated BP, and smoking status. Uric Acid 38-47 C-reactive protein Homo sapiens 238-241
16756969-9 2006 The strongest predictor of TAOC(ECL) was uric acid (1 SD increase associated with TAOC(ECL) increase of 103 micromol/l Teq-95% CI: 96.8-109), followed by vitamins A, C, E. CONCLUSIONS: The reported model represents a powerful tool for interrogating databases where individual serum antioxidant concentrations are known, and TAOC measures are required. Uric Acid 41-50 C-C motif chemokine ligand 21 Homo sapiens 27-36
16756969-9 2006 The strongest predictor of TAOC(ECL) was uric acid (1 SD increase associated with TAOC(ECL) increase of 103 micromol/l Teq-95% CI: 96.8-109), followed by vitamins A, C, E. CONCLUSIONS: The reported model represents a powerful tool for interrogating databases where individual serum antioxidant concentrations are known, and TAOC measures are required. Uric Acid 41-50 C-C motif chemokine ligand 21 Homo sapiens 32-35
16861244-0 2006 Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis? Uric Acid 72-77 uromodulin Homo sapiens 5-26
16861244-3 2006 However, it remains unclear how a mutation in THP, a protein produced in the thick ascending limb, can cause hyperuricaemia when most of the uric acid transport is believed to occur in the proximal tubule. Uric Acid 141-150 uromodulin Homo sapiens 46-49
16861244-5 2006 Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron. Uric Acid 63-72 uromodulin Homo sapiens 45-48
16861244-6 2006 METHODS: We screened for uric acid binding to THP using four independent binding assays. Uric Acid 25-34 uromodulin Homo sapiens 46-49
17031260-3 2006 The objective of this study was to investigate the protective effect of the coadministration of NCX-4016 [2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester] (an NO donor) with antioxidants Tempol, superoxide dismutase (SOD), or urate on I/R injury. Uric Acid 235-240 solute carrier family 8 member A1 Rattus norvegicus 96-99
16873376-8 2006 In addition, we show that urinary excretion of urate is significantly elevated in c/ebpdelta-/- mice even though the expression of URAT1, the transporter responsible for the apical membrane uptake of urate in renal proximal tubule, is not altered. Uric Acid 47-52 CCAAT/enhancer binding protein (C/EBP), delta Mus musculus 82-95
16873376-8 2006 In addition, we show that urinary excretion of urate is significantly elevated in c/ebpdelta-/- mice even though the expression of URAT1, the transporter responsible for the apical membrane uptake of urate in renal proximal tubule, is not altered. Uric Acid 200-205 CCAAT/enhancer binding protein (C/EBP), delta Mus musculus 82-95
16873376-8 2006 In addition, we show that urinary excretion of urate is significantly elevated in c/ebpdelta-/- mice even though the expression of URAT1, the transporter responsible for the apical membrane uptake of urate in renal proximal tubule, is not altered. Uric Acid 200-205 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 131-136
16873376-10 2006 Thus, the fortuitous double knock-out of slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice reveals the physiologic role of these transporters in the renal handling of lactate and urate. Uric Acid 180-185 solute carrier family 5 (iodide transporter), member 8 Mus musculus 41-47
16873376-10 2006 Thus, the fortuitous double knock-out of slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice reveals the physiologic role of these transporters in the renal handling of lactate and urate. Uric Acid 180-185 solute carrier family 5 (sodium/glucose cotransporter), member 12 Mus musculus 52-59
16873376-10 2006 Thus, the fortuitous double knock-out of slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice reveals the physiologic role of these transporters in the renal handling of lactate and urate. Uric Acid 180-185 CCAAT/enhancer binding protein (C/EBP), delta Mus musculus 73-86
16689679-1 2006 26904 and its application to serum uric acid assay by a patented kinetic uricase method. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 73-80
16689679-10 2006 By analysing the data monitored within 5 min at 0.03 unit/ml uricase, this kinetic uricase method gave linear response to uric acid in reaction solution from 1.3 to 60 micromol/l. Uric Acid 122-131 urate oxidase (pseudogene) Homo sapiens 61-68
16689679-10 2006 By analysing the data monitored within 5 min at 0.03 unit/ml uricase, this kinetic uricase method gave linear response to uric acid in reaction solution from 1.3 to 60 micromol/l. Uric Acid 122-131 urate oxidase (pseudogene) Homo sapiens 83-90
16689679-12 2006 Uric acid in clinical sera by this kinetic uricase method (Ck) closely and positively correlated with that from the indirect equilibrium method (Ce) (Ck = 0.008+1.081 x Ce, r>0.990, n=99). Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 43-50
16689679-14 2006 These results indicated that this kinetic uricase method using this uricase was reliable for serum uric acid assay with enhanced resistance to xanthine besides other common errors. Uric Acid 99-108 urate oxidase (pseudogene) Homo sapiens 42-49
16689679-14 2006 These results indicated that this kinetic uricase method using this uricase was reliable for serum uric acid assay with enhanced resistance to xanthine besides other common errors. Uric Acid 99-108 urate oxidase (pseudogene) Homo sapiens 68-75
17031260-7 2006 However, treatment of hearts with NCX-4016 + Tempol, SOD, or urate showed a significantly enhanced recovery of heart function compared with NCX-4016 alone. Uric Acid 61-66 solute carrier family 8 member A1 Rattus norvegicus 34-37
16941682-6 2006 In these animals, mitochondrial proteins were markedly tyrosine nitrated, particularly the ND4 subunit of complex I and cytochrome c. Treatment of these animals with uric acid, a peroxynitrite scavenger, anti-TNF antibody, or MnTBAP decreased tyrosine nitrated proteins, improved the activity of MRC complexes, and led to a marked regression of hepatic steatosis and inflammation. Uric Acid 166-175 NADH dehydrogenase 4, mitochondrial Mus musculus 91-94
16941682-6 2006 In these animals, mitochondrial proteins were markedly tyrosine nitrated, particularly the ND4 subunit of complex I and cytochrome c. Treatment of these animals with uric acid, a peroxynitrite scavenger, anti-TNF antibody, or MnTBAP decreased tyrosine nitrated proteins, improved the activity of MRC complexes, and led to a marked regression of hepatic steatosis and inflammation. Uric Acid 166-175 tumor necrosis factor Mus musculus 209-212
16865746-2 2006 Octyl (C8), decyl (C10), and dodecyl (C12) gallates competitively inhibited uric acid formation generated by xanthine oxidase, and the inhibition increased upon increasing the alkyl chain length. Uric Acid 76-85 chromosome 12 open reading frame 57 Homo sapiens 19-22
16678460-2 2006 Apparently in most HRH patients, the disorder is caused by loss of function mutations in the gene SLC22A12 coding for human urate transporter 1 (hURAT1), shown to control urate reabsorption in the proximal tubules. Uric Acid 124-129 solute carrier family 22 member 12 Homo sapiens 98-106
16678460-2 2006 Apparently in most HRH patients, the disorder is caused by loss of function mutations in the gene SLC22A12 coding for human urate transporter 1 (hURAT1), shown to control urate reabsorption in the proximal tubules. Uric Acid 124-129 solute carrier family 22 member 12 Homo sapiens 145-151
16908954-10 2006 Uric acid and body mass index were independent variables for adiponectin (adjusted R2 = 0.429). Uric Acid 0-9 adiponectin, C1Q and collagen domain containing Homo sapiens 61-72
16478971-6 2006 The organic anions ochratoxin A, salicylate, penicillin G, p-aminohippurate, and urate inhibited mOat6-mediated accumulation to varying degrees. Uric Acid 70-75 solute carrier family 22 (organic anion transporter), member 20 Mus musculus 97-102
16864933-8 2006 CONCLUSIONS: High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF. Uric Acid 25-27 natriuretic peptide B Homo sapiens 116-119
16886064-0 2006 MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. Uric Acid 90-106 myeloid differentiation primary response gene 88 Mus musculus 0-5
16886064-0 2006 MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. Uric Acid 90-106 interleukin 1 complex Mus musculus 16-20
16500633-10 2006 CONCLUSION: Our results revealed that low levels of haptoglobin in the two DS/G patients were related to renal dysfunction may have affected uric acid excretion and caused gout. Uric Acid 141-150 haptoglobin Homo sapiens 52-63
16714057-4 2006 In multivariate analysis across 12 variables, waist circumference, sex, complement C3, moderate alcohol intake and uric acid were significant independent covariates of serum GGT. Uric Acid 115-124 gamma-glutamyltransferase light chain family member 3 Homo sapiens 174-177
16682609-9 2006 In the low birth weight group, multiple regression analysis revealed that uric acid (beta=-2.886; SE=1.393; P=0.040) had a graded inverse relationship with flow-mediated dilation, which was not affected in a model adjusting for race and gender. Uric Acid 74-83 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 85-92
16522659-2 2006 We recently found metabolic factors, especially uric acid, to predict progression and marked histopathological lesions in IgAN. Uric Acid 48-57 IGAN1 Homo sapiens 122-126
16830944-1 2006 In this paper, uricase, catalase, and electron mediator were coimmobilized on the surface of the tin oxide (SnO2)/indium tin oxide (ITO) glass, to develop a disposable potentiometric uric acid biosensor. Uric Acid 183-192 urate oxidase (pseudogene) Homo sapiens 15-22
16830944-1 2006 In this paper, uricase, catalase, and electron mediator were coimmobilized on the surface of the tin oxide (SnO2)/indium tin oxide (ITO) glass, to develop a disposable potentiometric uric acid biosensor. Uric Acid 183-192 catalase Homo sapiens 24-32
16775029-6 2006 It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease. Uric Acid 59-68 solute carrier family 22 member 12 Homo sapiens 20-25
16775029-6 2006 It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease. Uric Acid 161-170 solute carrier family 22 member 12 Homo sapiens 20-25
16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 204-213 insulin Homo sapiens 8-15
16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 215-217 insulin Homo sapiens 8-15
16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 307-309 insulin Homo sapiens 8-15
17048203-6 2006 ACR was highly correlated to diastolic (r=0.88, p<0.001) and systolic (r=0.74, p<0.001) BP, and also--though not as strongly--to serum UA (r=0.38, p<0.001). Uric Acid 141-143 acrosin Homo sapiens 0-3
16672142-5 2006 Uric acid causes hypertension in a rat model through the activation of the renin-angiotensin system, downregulation of nitric oxide, and induction of endothelial dysfunction and vascular smooth muscle proliferation. Uric Acid 0-9 renin Rattus norvegicus 75-80
16901081-2 2006 Recent molecular identification of urate transporter-1 (URAT1) as the central mediator of renal urate reabsorption has provided novel understanding of the pathogenesis of hyperuricemia, and the target site for current and possibly future primary uricosuric agents. Uric Acid 35-40 solute carrier family 22 member 12 Homo sapiens 56-61
16569733-6 2006 RESULTS: Children with high CRP concentrations (highest tertile) had higher body mass index (BMI) sd scores, insulin, insulin resistance, uric acid, and adipocytokines and had more atherogenic lipoprotein profiles than other children. Uric Acid 138-147 C-reactive protein Homo sapiens 28-31
16831320-1 2006 OBJECTIVE: To study the islet beta-cell function in patients with simple hyperuricemia (HUA) and to explore the relationship between the level of serum uric acid and insulin resistance. Uric Acid 152-161 insulin Homo sapiens 166-173
16831320-7 2006 CONCLUSION: The islet beta-cell function in hyperuricemic patients increases compensatively and the serum uric acid level is positively correlated with insulin resistance. Uric Acid 106-115 insulin Homo sapiens 152-159
16522692-9 2006 Age- and uric acid-adjusted PEDF levels were significantly higher (P = 0.048 for men and P = 0.007 for women) in proportion to the accumulation of the number of the components of the metabolic syndrome. Uric Acid 9-18 serpin family F member 1 Homo sapiens 28-32
16691645-0 2006 Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method. Uric Acid 49-58 urate oxidase (pseudogene) Homo sapiens 24-31
16691645-0 2006 Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method. Uric Acid 49-58 urate oxidase (pseudogene) Homo sapiens 104-111
16691645-1 2006 A patented kinetic uricase method was evaluated for serum uric acid assay. Uric Acid 58-67 urate oxidase (pseudogene) Homo sapiens 19-26
16691645-8 2006 Uric acid concentrations in clinic sera by different uricase methods positively correlated to each other. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 53-60
16691645-10 2006 These results demonstrated that this kinetic uricase method is reliable for serum uric acid assay with enhanced resistance to both xanthine and other common errors, wider range of linear response and much lower cost. Uric Acid 82-91 urate oxidase (pseudogene) Homo sapiens 45-52
16556649-8 2006 These bands were also recognized in INF1-treated BY-2 cells and were found to be slightly suppressed by urate. Uric Acid 104-109 F-box protein PP2-B11-like Nicotiana tabacum 49-53
16672144-0 2006 Uric acid: its relationship to renal hemodynamics and the renal renin-angiotensin system. Uric Acid 0-9 renin Homo sapiens 64-69
16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 C-reactive protein Homo sapiens 119-137
16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 6 Homo sapiens 139-143
16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 1 receptor antagonist Homo sapiens 145-151
16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 18 Homo sapiens 153-158
16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 tumor necrosis factor Homo sapiens 164-173
16645020-11 2006 DS-TNFR2 was inversely associated with body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, fasting serum glucose, serum triglycerides and serum uric acid concentration and with the HOMA value (P = 0.03) in the replication study. Uric Acid 168-177 TNF receptor superfamily member 1B Homo sapiens 3-8
16284212-8 2006 The TNF-induced increase in the nitrotyrosine/beta-actin ratio and permeability were prevented by the anti-ONOO(-) agent Urate. Uric Acid 121-126 tumor necrosis factor Homo sapiens 4-7
16611716-5 2006 Serum creatinine, CRP, and maximal vasodilatory response to ACh were related to the UA (all P < 0.0001). Uric Acid 84-86 C-reactive protein Homo sapiens 18-21
16611716-6 2006 In the multiple regression analysis, serum UA ranked as the third correlate of peak of forearm blood flow predictor, after homeostasis model assessment and CRP. Uric Acid 43-45 C-reactive protein Homo sapiens 156-159
16611716-7 2006 The data show an independent link between UA and endothelial function, also in a statistical model that included CRP. Uric Acid 42-44 C-reactive protein Homo sapiens 113-116
16249272-6 2006 Male and female NHERF-1 null mice also demonstrate increased urine calcium/creatinine and uric acid/creatinine ratios compared with wild-type controls. Uric Acid 90-99 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 16-23
16249272-7 2006 These studies indicate defects in the renal tubule transport of phosphate, calcium, and uric acid in NHERF-1(-/-) male and female mice that could account for the increased deposition of calcium in the papilla of null mice. Uric Acid 88-97 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 101-108
16284212-8 2006 The TNF-induced increase in the nitrotyrosine/beta-actin ratio and permeability were prevented by the anti-ONOO(-) agent Urate. Uric Acid 121-126 POTE ankyrin domain family member F Homo sapiens 46-56
16452486-1 2006 Xanthine oxidoreductase (XOR) catalyzes the formation of uric acid from xanthine and hypoxanthine and is recognized as a source of reactive oxygen and nitrogen species. Uric Acid 57-66 xanthine dehydrogenase Mus musculus 0-23
16785612-7 2006 However, the high insulin response group was associated with higher BMI, subcutanesous fat area, uric acid levels, HOMA-beta cell values, and delta insulin/delta glucose (30 min) than the low insulin response group. Uric Acid 97-106 insulin Homo sapiens 18-25
16452486-1 2006 Xanthine oxidoreductase (XOR) catalyzes the formation of uric acid from xanthine and hypoxanthine and is recognized as a source of reactive oxygen and nitrogen species. Uric Acid 57-66 xanthine dehydrogenase Mus musculus 25-28
16314875-9 2006 In men, CRP was independently and positively associated to waist circumference, smoking, diastolic blood pressure, uric acid and triglycerides, and negatively associated to HDL-cholesterol. Uric Acid 115-124 C-reactive protein Homo sapiens 8-11
16407889-0 2006 Gout-associated uric acid crystals activate the NALP3 inflammasome. Uric Acid 16-25 NLR family, pyrin domain containing 3 Mus musculus 48-53
16385546-1 2006 OBJECTIVE: Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Uric Acid 17-22 solute carrier family 22 member 12 Homo sapiens 38-44
16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 7-26
16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 190-195
16406656-3 2006 In addition, in an animal in vivo experiment, MSU crystals were injected into subcutaneous air pouches of IL-18-deficient mice. Uric Acid 46-49 interleukin 18 Mus musculus 106-111
16505518-6 2006 RESULTS: Significant genetic correlations were detected among BMI, waist circumference, HDL cholesterol, triglycerides, insulin, and plasminogen activator inhibitor-1 antigen and between uric acid and all of the above variables except insulin. Uric Acid 187-196 insulin Homo sapiens 120-127
16447220-0 2006 Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Uric Acid 107-135 triggering receptor expressed on myeloid cells 1 Mus musculus 13-61
16447220-3 2006 In the present study, we investigated the role of TREM-1 in acute inflammation induced by monosodium urate monohydrate (MSU) crystals. Uric Acid 90-118 triggering receptor expressed on myeloid cells 1 Mus musculus 50-56
16447220-3 2006 In the present study, we investigated the role of TREM-1 in acute inflammation induced by monosodium urate monohydrate (MSU) crystals. Uric Acid 120-123 triggering receptor expressed on myeloid cells 1 Mus musculus 50-56
16437741-6 2006 Potassium oxonate, a urate oxidase inhibitor, can raise the serum uric acid level by inhibiting the decomposition of uric acid. Uric Acid 66-75 urate oxidase Rattus norvegicus 21-34
16437741-6 2006 Potassium oxonate, a urate oxidase inhibitor, can raise the serum uric acid level by inhibiting the decomposition of uric acid. Uric Acid 117-126 urate oxidase Rattus norvegicus 21-34
16500885-7 2006 In the partial correlation analysis, after controlling for sex, age and BMI, serum uric acid was significantly positively correlated with serum concentrations of TC (r = 0.205, P = 0.001), LDL-C (r = 0.229, P < 0.001),TAG (r = 0.172, P = 0.008) and creatinine (r = 0.330, P < 0.001). Uric Acid 83-92 component of oligomeric golgi complex 2 Homo sapiens 189-194
16809136-0 2006 An amperometric biosensor for uric acid determination prepared from uricase immobilized in polypyrrole film. Uric Acid 30-39 urate oxidase (pseudogene) Homo sapiens 68-75
16385546-1 2006 OBJECTIVE: Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Uric Acid 17-22 solute carrier family 22 member 12 Homo sapiens 99-107
16820043-2 2006 The aims of this review are to highlight exciting and clinically pertinent advances in our understanding of how uric acid is reabsorbed by the kidney under the regulation of urate transporter (URAT)1 and other recently identified urate transporters; to discuss urate-lowering agents in clinical development; and to summarize the limitations of currently available antihyperuricemic drugs. Uric Acid 112-121 solute carrier family 22 member 12 Homo sapiens 174-199
16385546-3 2006 The present case-control study was designed to analyze whether hURAT1 might also be a candidate gene for hyperuricemia with primary reduced renal urate excretion. Uric Acid 146-151 solute carrier family 22 member 12 Homo sapiens 63-69
16377929-5 2006 Serum UA level was independently associated with the prevalence of hypertension (odds ratio (95% confidence interval) =2.7 (1.2-5.9), p=0.047) for the highest tertile of serum UA (>or=398.5 micromol/L (6.7 mg/dl)) vs that of the lowest tertile (<321.2 micromol/L (5.4 mg/dl)), but the MTHFR mutation was not independently associated with prevalence of hypertension or BP. Uric Acid 6-8 methylenetetrahydrofolate reductase Homo sapiens 291-296
16809910-8 2006 Furthermore, although there were significant correlations between serum and CSF UA levels in the control and traumatic tap groups, no correlation was observed in the IVH group. Uric Acid 80-82 nuclear RNA export factor 1 Homo sapiens 119-122
16809910-9 2006 CONCLUSION: CSF UA levels are increased in neonates with IVH and they may be used to differentiate a real hemorrhage from a traumatic tap. Uric Acid 16-18 nuclear RNA export factor 1 Homo sapiens 134-137
16521070-2 2006 The absence of uricase, due to nonsense or splice mutations occurring during the evolution of primates, results in blood urate levels much higher in humans than in other mammalians. Uric Acid 121-126 urate oxidase (pseudogene) Homo sapiens 15-22
16430098-4 2006 Significant reduction in serum total protein and cholesterol levels and rise in serum uric acid and LDH levels of broilers were observed due to dietary T-2 toxin. Uric Acid 86-95 solute carrier family 25 member 5 Homo sapiens 152-155
16879063-3 2006 We researched the relationship between serum uric acid, creatinine and albumin levels in pregnant women with normal glucose tolerance and gestational diabetes mellitus. Uric Acid 45-54 albumin Homo sapiens 71-78
16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 291-296
16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 platelet derived growth factor subunit A Homo sapiens 298-304
16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 C-reactive protein Homo sapiens 385-403
16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 408-442
16328014-5 2006 The odds ratios to AA genotype were significant for uric acid (GG, 0.52; AG, 0.59), obesity (AG, 0.24) in males and for high-density lipoprotein cholesterol (GG, 0.11; AG, 0.36), gamma-glutamyl transpeptidase (GG, 0.53; AG, 0.62) and total cholesterol (GG, 1.84) in females. Uric Acid 52-61 inactive glutathione hydrolase 2 Homo sapiens 179-208
16898490-18 2006 Anti-Hsp70 correlated with serum uric acid (R=-0.82, p=0.04), cholesterol (R=-0.78, p=0.03), CHOL/LDL-C (R=-0.89, p=0.007) and CHOL/TGL (R=-0.75, p=0.03) in gr. Uric Acid 33-42 heat shock protein family A (Hsp70) member 4 Homo sapiens 5-10
16712512-3 2006 The activation energy requirement for uric acid hydrolysis by uricase and inactivation of enzyme were 11.6 and 14.5 kJ/M respectively. Uric Acid 38-47 urate oxidase Bos taurus 62-69
16897192-0 2006 Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men. Uric Acid 130-139 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 21-49
16898490-22 2006 CONCLUSIONS: Preliminary results point at relations between anti-Hsp70, markers of chronic inflammation (ESR) and atherosclerotic risk (uric acid, cholesterol) in CRF children. Uric Acid 136-145 heat shock protein family A (Hsp70) member 4 Homo sapiens 65-70
16250053-5 2005 Reduction of STAT1 phosphorylation by ethanol was prevented in the presence of 4MP, DAS, or uric acid, indicating that the oxidative products from ethanol metabolism were partly responsible for suppression of STAT1 phosphorylation. Uric Acid 92-101 signal transducer and activator of transcription 1 Homo sapiens 13-18
16135657-4 2005 Benzbromarone is an inhibitor of reabsorption of uric acid mediated by the uric acid transporter (URAT) URAT1 (SLC22A12), which is expressed at the apical membrane of proximal tubular cells in humans. Uric Acid 49-58 solute carrier family 22 member 12 Homo sapiens 104-109
16135657-4 2005 Benzbromarone is an inhibitor of reabsorption of uric acid mediated by the uric acid transporter (URAT) URAT1 (SLC22A12), which is expressed at the apical membrane of proximal tubular cells in humans. Uric Acid 49-58 solute carrier family 22 member 12 Homo sapiens 111-119
16251237-0 2005 Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Uric Acid 0-9 C-reactive protein Homo sapiens 18-36
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 26-35 C-reactive protein Homo sapiens 109-112
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 37-39 C-reactive protein Homo sapiens 109-112
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 37-39 C-reactive protein Homo sapiens 143-146
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 37-39 C-reactive protein Homo sapiens 143-146
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 118-120 C-reactive protein Homo sapiens 109-112
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 118-120 C-reactive protein Homo sapiens 143-146
16251237-4 2005 For investigating whether uric acid (UA)-induced inflammatory reaction and vascular remodeling is related to CRP, the UA-induced expression of CRP in human vascular smooth muscle cells (HVSMC) and human umbilical vein endothelial cells (HUVEC) was examined, as well as the pathogenetic role of CRP in vascular remodeling. Uric Acid 118-120 C-reactive protein Homo sapiens 143-146
16251237-7 2005 Inhibition of p38 or extracellular signal-regulated kinase 44/42 significantly suppressed UA-induced CRP expression, implicating these pathways in the response to UA. Uric Acid 90-92 mitogen-activated protein kinase 14 Homo sapiens 14-17
16251237-7 2005 Inhibition of p38 or extracellular signal-regulated kinase 44/42 significantly suppressed UA-induced CRP expression, implicating these pathways in the response to UA. Uric Acid 90-92 C-reactive protein Homo sapiens 101-104
16251237-7 2005 Inhibition of p38 or extracellular signal-regulated kinase 44/42 significantly suppressed UA-induced CRP expression, implicating these pathways in the response to UA. Uric Acid 163-165 mitogen-activated protein kinase 14 Homo sapiens 14-17
16251237-7 2005 Inhibition of p38 or extracellular signal-regulated kinase 44/42 significantly suppressed UA-induced CRP expression, implicating these pathways in the response to UA. Uric Acid 163-165 C-reactive protein Homo sapiens 101-104
16251237-8 2005 UA stimulated HVSMC proliferation whereas UA inhibited serum-induced proliferation of HUVEC assessed by 3H-thymidine uptake and cell counting, which was attenuated by co-incubation with probenecid, the organic anion transport inhibitor, suggesting that entry of UA into cells is responsible for CRP expression. Uric Acid 0-2 C-reactive protein Homo sapiens 295-298
16251237-8 2005 UA stimulated HVSMC proliferation whereas UA inhibited serum-induced proliferation of HUVEC assessed by 3H-thymidine uptake and cell counting, which was attenuated by co-incubation with probenecid, the organic anion transport inhibitor, suggesting that entry of UA into cells is responsible for CRP expression. Uric Acid 42-44 C-reactive protein Homo sapiens 295-298
16251237-8 2005 UA stimulated HVSMC proliferation whereas UA inhibited serum-induced proliferation of HUVEC assessed by 3H-thymidine uptake and cell counting, which was attenuated by co-incubation with probenecid, the organic anion transport inhibitor, suggesting that entry of UA into cells is responsible for CRP expression. Uric Acid 42-44 C-reactive protein Homo sapiens 295-298
16251237-11 2005 Treatment of vascular cells with anti-CRP antibody revealed a reversal of the effect of UA on cell proliferation and migration in HVSMC and NO release in HUVEC, which suggests that CRP expression may be responsible for UA-induced vascular remodeling. Uric Acid 88-90 C-reactive protein Homo sapiens 38-41
16251237-11 2005 Treatment of vascular cells with anti-CRP antibody revealed a reversal of the effect of UA on cell proliferation and migration in HVSMC and NO release in HUVEC, which suggests that CRP expression may be responsible for UA-induced vascular remodeling. Uric Acid 88-90 C-reactive protein Homo sapiens 181-184
16251237-13 2005 The observation that UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease. Uric Acid 21-23 C-reactive protein Homo sapiens 129-132
16263504-0 2005 Associations of uric acid with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. Uric Acid 16-25 aminolevulinate dehydratase Homo sapiens 52-89
16263504-0 2005 Associations of uric acid with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. Uric Acid 16-25 vitamin D receptor Homo sapiens 91-109
16263504-6 2005 Among older workers (age > or = median of 40.6 years), ALAD genotype modified associations between lead dose and uric acid levels. Uric Acid 116-125 aminolevulinate dehydratase Homo sapiens 58-62
16437656-3 2005 RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference, hs-CRP, triglyceride values, and GGT levels. Uric Acid 246-255 glutamic--pyruvic transaminase Homo sapiens 113-116
16932373-3 2005 We recently reported that uric acid reduces levels of endothelial nitric oxide (NO), a key mediator of insulin action. Uric Acid 26-35 insulin Homo sapiens 103-110
16250053-5 2005 Reduction of STAT1 phosphorylation by ethanol was prevented in the presence of 4MP, DAS, or uric acid, indicating that the oxidative products from ethanol metabolism were partly responsible for suppression of STAT1 phosphorylation. Uric Acid 92-101 signal transducer and activator of transcription 1 Homo sapiens 209-214
16154428-0 2005 Possible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among Japanese. Uric Acid 139-148 nitric oxide synthase 3 Homo sapiens 29-75
16358551-7 2005 The age at onset of cigarette smoking showed a positive correlation with HGPRT activity after adjusting for smoking duration, serum uric acid, and cigarettes smoked per year using a multiple regression model (p < 0.001). Uric Acid 132-141 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 73-78
16140208-0 2005 Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses. Uric Acid 85-94 insulin Homo sapiens 0-7
16140208-6 2005 Oxidative stress-induced decreases in intracellular uric acid and GSH/GSSG levels were largely prevented upon treatment with insulin. Uric Acid 52-61 insulin Homo sapiens 125-132
16140208-7 2005 Inhibition of phosphatidylinositol-3-kinase (PI-3K) or mitogen-induced extracellular kinase (MEK) reversed the effect of insulin on uric acid and GSH/GSSG, suggesting the activation of insulin-mediated signaling pathways. Uric Acid 132-141 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 14-43
16140208-7 2005 Inhibition of phosphatidylinositol-3-kinase (PI-3K) or mitogen-induced extracellular kinase (MEK) reversed the effect of insulin on uric acid and GSH/GSSG, suggesting the activation of insulin-mediated signaling pathways. Uric Acid 132-141 mitogen-activated protein kinase kinase 7 Homo sapiens 55-91
16140208-7 2005 Inhibition of phosphatidylinositol-3-kinase (PI-3K) or mitogen-induced extracellular kinase (MEK) reversed the effect of insulin on uric acid and GSH/GSSG, suggesting the activation of insulin-mediated signaling pathways. Uric Acid 132-141 mitogen-activated protein kinase kinase 7 Homo sapiens 93-96
16140208-7 2005 Inhibition of phosphatidylinositol-3-kinase (PI-3K) or mitogen-induced extracellular kinase (MEK) reversed the effect of insulin on uric acid and GSH/GSSG, suggesting the activation of insulin-mediated signaling pathways. Uric Acid 132-141 insulin Homo sapiens 121-128
16382292-2 2005 The transformation of hypoxanthine to xanthine and the conversion of the latter into uric acid, which occur in purine catabolism, are catalysed by xanthine oxidoreductase. Uric Acid 85-94 xanthine dehydrogenase Homo sapiens 147-170
16382292-4 2005 Allopurinol and oxypurinol inhibit xanthine oxidoreductase and thus diminish the generation of reactive species and decrease plasma uric acid. Uric Acid 132-141 xanthine dehydrogenase Homo sapiens 35-58
16154428-1 2005 A variable number of tandem repeat polymorphism located in intron 4 of the gene for endothelial constitutive nitric oxide synthase (ecNOS) is reported to be significantly associated with the nitric oxide level, which influences serum uric acid (SUA). Uric Acid 234-243 nitric oxide synthase 3 Homo sapiens 84-130
16154428-1 2005 A variable number of tandem repeat polymorphism located in intron 4 of the gene for endothelial constitutive nitric oxide synthase (ecNOS) is reported to be significantly associated with the nitric oxide level, which influences serum uric acid (SUA). Uric Acid 234-243 nitric oxide synthase 3 Homo sapiens 132-137
16370207-3 2005 The promotors (oxalate, calcium, uric acid, phosphates) and inhibitors (citrate, magnesium) are statistically significant between G1, G2 and G3, G2. Uric Acid 33-42 proline rich protein BstNI subfamily 3 Homo sapiens 130-147
16180093-4 2005 In an attempt to reduce glycoxidation and formation of advanced glycation products (AGE), influence of 0.2-1.2 mM uric acid as endogenous antioxidant on glycoxidation of purified pig heart aspartate aminotransferase (AST) by 50 mM and 500 mM D-fructose in vitro was studied. Uric Acid 114-123 AST Sus scrofa 189-215
16180093-4 2005 In an attempt to reduce glycoxidation and formation of advanced glycation products (AGE), influence of 0.2-1.2 mM uric acid as endogenous antioxidant on glycoxidation of purified pig heart aspartate aminotransferase (AST) by 50 mM and 500 mM D-fructose in vitro was studied. Uric Acid 114-123 AST Sus scrofa 217-220
16180093-5 2005 Uric acid at 1.2 mM concentration reduced AST activity decrease and formation of total AGE products caused by incubation in vitro of the enzyme with sugar up to 25 days at 37 degrees C. The results thus support the hypothesis that uric acid has beneficial effects in controlling protein glycoxidation. Uric Acid 0-9 AST Sus scrofa 42-45
16180093-5 2005 Uric acid at 1.2 mM concentration reduced AST activity decrease and formation of total AGE products caused by incubation in vitro of the enzyme with sugar up to 25 days at 37 degrees C. The results thus support the hypothesis that uric acid has beneficial effects in controlling protein glycoxidation. Uric Acid 231-240 AST Sus scrofa 42-45
16142712-0 2005 Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Uric Acid 120-148 myeloid differentiation primary response gene 88 Mus musculus 61-94
16113518-1 2005 BACKGROUND: Soluble uric acid stimulates vascular smooth muscle cell (VSMC) proliferation by activating mitogen-activated protein kinases, and stimulating COX-2 and PDGF synthesis. Uric Acid 20-29 cytochrome c oxidase II, mitochondrial Rattus norvegicus 155-160
16113518-10 2005 CONCLUSIONS: Urate enters VSMC by both voltage-sensitive and OAT pathways, and the uptake, cell proliferation and MCP-1 expression can be blocked by OAT inhibitors. Uric Acid 13-18 C-C motif chemokine ligand 2 Rattus norvegicus 114-119
16142712-7 2005 Neutrophil influx and local induction of IL-1beta in subcutaneous air pouches were suppressed 6 hours after injection of MSU crystals in TLR-2-/- and TLR-4-/- mice and were attenuated in MyD88-/- mice. Uric Acid 121-124 interleukin 1 beta Mus musculus 41-49
16142712-7 2005 Neutrophil influx and local induction of IL-1beta in subcutaneous air pouches were suppressed 6 hours after injection of MSU crystals in TLR-2-/- and TLR-4-/- mice and were attenuated in MyD88-/- mice. Uric Acid 121-124 toll-like receptor 2 Mus musculus 137-142
16142712-7 2005 Neutrophil influx and local induction of IL-1beta in subcutaneous air pouches were suppressed 6 hours after injection of MSU crystals in TLR-2-/- and TLR-4-/- mice and were attenuated in MyD88-/- mice. Uric Acid 121-124 toll-like receptor 4 Mus musculus 150-155
16142712-7 2005 Neutrophil influx and local induction of IL-1beta in subcutaneous air pouches were suppressed 6 hours after injection of MSU crystals in TLR-2-/- and TLR-4-/- mice and were attenuated in MyD88-/- mice. Uric Acid 121-124 myeloid differentiation primary response gene 88 Mus musculus 187-192
16142712-8 2005 CONCLUSION: The murine host requires TLR-2, TLR-4, and MyD88 for macrophage activation and development of full-blown neutrophilic, air pouch inflammation in response to MSU crystals. Uric Acid 169-172 toll-like receptor 2 Mus musculus 37-42
16142712-8 2005 CONCLUSION: The murine host requires TLR-2, TLR-4, and MyD88 for macrophage activation and development of full-blown neutrophilic, air pouch inflammation in response to MSU crystals. Uric Acid 169-172 toll-like receptor 4 Mus musculus 44-49
16142712-8 2005 CONCLUSION: The murine host requires TLR-2, TLR-4, and MyD88 for macrophage activation and development of full-blown neutrophilic, air pouch inflammation in response to MSU crystals. Uric Acid 169-172 myeloid differentiation primary response gene 88 Mus musculus 55-60
16202255-7 2005 CONCLUSIONS: Serum uric acid level was strongly associated with triglyceride independent of age, genders, smoking, alcohol consumption, obesity and insulin resistance. Uric Acid 19-28 insulin Homo sapiens 148-155
16142876-0 2005 Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch. Uric Acid 66-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 40-45
16041161-7 2005 CONCLUSIONS: Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome. Uric Acid 19-28 insulin Homo sapiens 103-110
16131500-1 2005 Our previous study has shown that uric acid is metabolized by recombinant rat urate oxidase (UOX) and generates hydrogen peroxide leading to DNA damage and cell transformation. Uric Acid 34-43 urate oxidase Rattus norvegicus 93-96
16131500-1 2005 Our previous study has shown that uric acid is metabolized by recombinant rat urate oxidase (UOX) and generates hydrogen peroxide leading to DNA damage and cell transformation. Uric Acid 34-43 urate oxidase Rattus norvegicus 78-91
16041161-0 2005 Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Uric Acid 27-36 insulin Homo sapiens 55-62
15928248-9 2005 Furthermore, adiponectin was positively correlated with high-density lipoprotein-free cholesterol and serum apolipoprotein-A1 and negatively with triglycerides, insulin resistance, uric acid, and serum transaminases. Uric Acid 181-190 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24
15784009-6 2005 Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid. Uric Acid 234-243 interleukin 1 beta Mus musculus 27-35
15784009-8 2005 Disruption of mitochondrial membrane potential and ATP deprivation were observed in IL-1beta-treated ATDC5 cells, both of which were restored by L-NAME, AEBSF or uric acid. Uric Acid 162-171 interleukin 1 beta Mus musculus 84-92
15939803-2 2005 The present study examines the association between serum uric acid (UA) elevation and the alpha2-, beta2-, and beta3-adrenoceptor polymorphisms. Uric Acid 57-66 adrenoceptor beta 3 Homo sapiens 111-129
15855386-8 2005 The transparent Malpighian tubule phenotype first identified in lethal alleles of vha55, the gene encoding the B-subunit, is shown to be general to those plasma membrane V-ATPase subunits for which lethal alleles are available, and to be caused by failure to accumulate uric acid crystals. Uric Acid 270-279 Vacuolar H[+]-ATPase 55kD subunit Drosophila melanogaster 82-87
15855386-8 2005 The transparent Malpighian tubule phenotype first identified in lethal alleles of vha55, the gene encoding the B-subunit, is shown to be general to those plasma membrane V-ATPase subunits for which lethal alleles are available, and to be caused by failure to accumulate uric acid crystals. Uric Acid 270-279 Vacuolar H[+]-ATPase 55kD subunit Drosophila melanogaster 111-120
15855386-8 2005 The transparent Malpighian tubule phenotype first identified in lethal alleles of vha55, the gene encoding the B-subunit, is shown to be general to those plasma membrane V-ATPase subunits for which lethal alleles are available, and to be caused by failure to accumulate uric acid crystals. Uric Acid 270-279 Vacuolar H[+]-ATPase 55kD subunit Drosophila melanogaster 170-178
15939803-2 2005 The present study examines the association between serum uric acid (UA) elevation and the alpha2-, beta2-, and beta3-adrenoceptor polymorphisms. Uric Acid 68-70 adrenoceptor beta 3 Homo sapiens 111-129
15921074-17 2005 There was a trend for increased serum uric acid levels with higher leptin concentrations. Uric Acid 38-47 leptin Homo sapiens 67-73
15941351-9 2005 Moreover, a good linear correlation was found between uric acid concentration and AC determined by FRAP in each volunteer. Uric Acid 54-63 mechanistic target of rapamycin kinase Homo sapiens 99-103
15941351-11 2005 Uric acid increase accounts for a nonnegligible part in FRAP values and must be evaluated when using this method for assessing AC in plasma. Uric Acid 0-9 mechanistic target of rapamycin kinase Homo sapiens 56-60
15840020-16 2005 Uric acid was also found to inhibit both basal and vascular endothelial growth factor (VEGF)-induced nitric oxide production in bovine aortic endothelial cells. Uric Acid 0-9 vascular endothelial growth factor A Bos taurus 51-85
15868628-0 2005 Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster. Uric Acid 14-19 apolipoprotein A1 Homo sapiens 68-85
15868628-1 2005 OBJECTIVE: The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. Uric Acid 93-98 apolipoprotein A1 Homo sapiens 15-32
15868628-1 2005 OBJECTIVE: The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. Uric Acid 93-98 apolipoprotein C3 Homo sapiens 139-158
15868628-2 2005 We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia. Uric Acid 106-111 apolipoprotein A1 Homo sapiens 50-67
15840020-16 2005 Uric acid was also found to inhibit both basal and vascular endothelial growth factor (VEGF)-induced nitric oxide production in bovine aortic endothelial cells. Uric Acid 0-9 vascular endothelial growth factor A Bos taurus 87-91
15899116-1 2005 BACKGROUND: Human urate anion exchanger (hURAT1) as a major urate transporter expressed on renal tubular epithelial cells regulates blood urate level by reabsorbing uric acid. Uric Acid 18-23 solute carrier family 22 member 12 Homo sapiens 41-47
15899116-1 2005 BACKGROUND: Human urate anion exchanger (hURAT1) as a major urate transporter expressed on renal tubular epithelial cells regulates blood urate level by reabsorbing uric acid. Uric Acid 165-174 solute carrier family 22 member 12 Homo sapiens 41-47
15838747-0 2005 Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance. Uric Acid 15-24 insulin Homo sapiens 80-87
15814732-0 2005 TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. Uric Acid 74-90 toll like receptor 2 Homo sapiens 0-4
15781018-3 2005 Mean serum levels of uric acid were higher in those who had an abnormal ratio of >/=3 for triglyceride to high-density lipoprotein (suggesting insulin resistance) than in those who had a normal ratio (6.6 +/- 1.2 vs 5.87 +/- 1 mg/dl, p <0.001). Uric Acid 21-30 insulin Homo sapiens 146-153
15838747-1 2005 The purpose of this study was to assess a possible correlation between insulin resistance and uric acid levels in gestational hypertension (GH) and preeclampsia. Uric Acid 94-103 insulin Homo sapiens 71-78
15838747-9 2005 The elevated serum uric acid levels were highly correlated to insulin resistance in patients with GH. Uric Acid 19-28 insulin Homo sapiens 62-69
15838747-11 2005 Insulin resistance is associated with the elevated uric acid levels found in nonproteinuric gestational hypertensive disease. Uric Acid 51-60 insulin Homo sapiens 0-7
15791030-4 2005 With adjustment for age, smoking status, and drinking status, the differences in CRP concentrations between those with the MS components of BMI, triglycerides, and uric acid and those without were greater in women than in men. Uric Acid 164-173 C-reactive protein Homo sapiens 81-84
15634722-5 2005 Urate-transporting activities of wild-type and mutant hURAT1 were determined by [14C]urate uptake in Xenopus oocytes. Uric Acid 0-5 solute carrier family 22 member 12 Homo sapiens 54-60
15821821-9 2005 Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. Uric Acid 128-137 fibrinogen beta chain Homo sapiens 0-10
15634722-5 2005 Urate-transporting activities of wild-type and mutant hURAT1 were determined by [14C]urate uptake in Xenopus oocytes. Uric Acid 85-90 solute carrier family 22 member 12 Homo sapiens 54-60
15634722-8 2005 All hURAT1 mutants had significantly reduced urate-transporting activities compared with wild type (P < 0.05; n = 12), suggesting that T1253G is a loss of function mutation, and hURAT1 is responsible for the presecretory reabsorption defect-type familial renal hypouricemia. Uric Acid 45-50 solute carrier family 22 member 12 Homo sapiens 4-10
15746665-11 2005 Our regression model revealed that uric acid correlated best with log[sFlt-1/PlGF] ratio (r = 0.628; P = .005). Uric Acid 35-44 placental growth factor Homo sapiens 77-81
15921030-0 2005 Effect of apolipoprotein E polymorphism on serum uric acid levels in healthy subjects. Uric Acid 49-58 apolipoprotein E Homo sapiens 10-26
15921030-2 2005 On the other hand, there are limited data regarding the possible influence of apo E- polymorphism on serum uric acid (SUA) levels. Uric Acid 107-116 apolipoprotein E Homo sapiens 78-83
16554868-8 2005 In preeclampsia there was positive significant correlations of raised TNF-alpha with uric acid (p<0.005). Uric Acid 85-94 tumor necrosis factor Homo sapiens 70-79
16554868-11 2005 In the present study, there was positive association of raised level of TNF-alpha with blood sugar / and uric acid levels. Uric Acid 105-114 tumor necrosis factor Homo sapiens 72-81
16472239-10 2005 The concentration of TNF-alpha was increased in the sample incubated with uric acid comparing to the control. Uric Acid 74-83 tumor necrosis factor Homo sapiens 21-30
15788238-2 2005 The only enzymatic source of urate is xanthine oxidoreductase. Uric Acid 29-34 xanthine dehydrogenase Homo sapiens 38-61
15788238-3 2005 If a major purpose of xanthine oxidoreductase is the production of urate to function as an iron chelator and antioxidant, a system for coupling the activity of this enzyme to the availability of catalytically-active metal would be required. Uric Acid 67-72 xanthine dehydrogenase Homo sapiens 22-45
15745839-3 2005 The addition of ascorbic acid at 0.05 mM or uric acid at 5 and 7 mg/dl significantly reduced LDH release, recovered GPx activity, suppressed H2O2 production, and decreased Fn and VEGF production (P<.05). Uric Acid 44-53 fibronectin 1 Homo sapiens 172-174
15745839-3 2005 The addition of ascorbic acid at 0.05 mM or uric acid at 5 and 7 mg/dl significantly reduced LDH release, recovered GPx activity, suppressed H2O2 production, and decreased Fn and VEGF production (P<.05). Uric Acid 44-53 vascular endothelial growth factor A Homo sapiens 179-183
15745839-0 2005 Ascorbic acid and uric acid suppress glucose-induced fibronectin and vascular endothelial growth factor production in human endothelial cells. Uric Acid 18-27 fibronectin 1 Homo sapiens 53-64
16532680-5 2005 All 5 samples from each man were included in multiple regression analysis and the prediction equation obtained was: serum gastrin, pg/mL = 198.27-0.199 total cholesterol (mg/dL) + 2.525 urea (mg/dL)--103.238 uric acid (mg/dL) + 10.923 uric acid (mg/dL)2 + 3.683 body mass index, r2 = 0.75, P < 0.001. Uric Acid 208-217 gastrin Homo sapiens 122-129
15745839-0 2005 Ascorbic acid and uric acid suppress glucose-induced fibronectin and vascular endothelial growth factor production in human endothelial cells. Uric Acid 18-27 vascular endothelial growth factor A Homo sapiens 69-103
15454390-0 2005 Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Uric Acid 93-98 ATP binding cassette subfamily C member 4 Homo sapiens 32-36
15454390-0 2005 Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Uric Acid 93-98 ATP binding cassette subfamily C member 4 Homo sapiens 38-43
15454390-3 2005 Here, we show that the renal apical organic anion efflux transporter human multidrug resistance protein 4 (MRP4), but not apical MRP2, mediates ATP-dependent urate transport via a positive cooperative mechanism (K(m) of 1.5 +/- 0.3 mM, V(max) of 47 +/- 7 pmol x mg(-1) x min(-1), and Hill coefficient of 1.7 +/- 0.2). Uric Acid 158-163 ATP binding cassette subfamily C member 4 Homo sapiens 75-105
15454390-3 2005 Here, we show that the renal apical organic anion efflux transporter human multidrug resistance protein 4 (MRP4), but not apical MRP2, mediates ATP-dependent urate transport via a positive cooperative mechanism (K(m) of 1.5 +/- 0.3 mM, V(max) of 47 +/- 7 pmol x mg(-1) x min(-1), and Hill coefficient of 1.7 +/- 0.2). Uric Acid 158-163 ATP binding cassette subfamily C member 4 Homo sapiens 107-111
15454390-4 2005 In HEK293 cells overexpressing MRP4, intracellular urate levels were lower than in control cells. Uric Acid 51-56 ATP binding cassette subfamily C member 4 Homo sapiens 31-35
15454390-5 2005 Urate inhibited methotrexate transport (IC50 of 235 +/- 8 microM) by MRP4, did not affect cAMP transport, whereas cGMP transport was stimulated. Uric Acid 0-5 ATP binding cassette subfamily C member 4 Homo sapiens 69-73
15454390-6 2005 Urate shifted cGMP transport by MRP4 from positive cooperativity (K(m) and V(max) value of 180 +/- 20 microM and 58 +/- 4 pmol x mg(-1) x min(-1), respectively, Hill coefficient of 1.4 +/- 0.1) to single binding site kinetics (K(m) and V(max) value of 2.2 +/- 0.9 mM and 280 +/- 50 pmol x mg(-1) x min(-1), respectively). Uric Acid 0-5 ATP binding cassette subfamily C member 4 Homo sapiens 32-36
15454390-7 2005 Finally, MRP4 could transport urate simultaneously with cAMP or cGMP. Uric Acid 30-35 ATP binding cassette subfamily C member 4 Homo sapiens 9-13
15454390-8 2005 We conclude that human MRP4 is a unidirectional efflux pump for urate with multiple allosteric substrate binding sites. Uric Acid 64-69 ATP binding cassette subfamily C member 4 Homo sapiens 23-27
15454390-9 2005 We propose MRP4 as a candidate transporter for urinary urate excretion and suggest that MRP4 may also mediate hepatic export of urate into the circulation, because of its basolateral expression in the liver. Uric Acid 55-60 ATP binding cassette subfamily C member 4 Homo sapiens 11-15
15696447-13 2005 Serum IL-8 levels correlated significantly with FE UA (P < 0.001; r = 0.785) and inversely with serum UA level (P = 0.044; r = -0.509); neither IL-6 nor TNF-alpha level showed such correlations. Uric Acid 51-53 C-X-C motif chemokine ligand 8 Homo sapiens 6-10
16375732-2 2005 Humans lack the enzyme uricase, which catalyzes the conversion of uric acid to allantoin. Uric Acid 66-75 urate oxidase (pseudogene) Homo sapiens 23-30
15454390-9 2005 We propose MRP4 as a candidate transporter for urinary urate excretion and suggest that MRP4 may also mediate hepatic export of urate into the circulation, because of its basolateral expression in the liver. Uric Acid 128-133 ATP binding cassette subfamily C member 4 Homo sapiens 11-15
15454390-9 2005 We propose MRP4 as a candidate transporter for urinary urate excretion and suggest that MRP4 may also mediate hepatic export of urate into the circulation, because of its basolateral expression in the liver. Uric Acid 128-133 ATP binding cassette subfamily C member 4 Homo sapiens 88-92
15803114-9 2005 CRP showed a positive correlation with BMI, insulin, homeostasis model assessment (HOMA), triglycerides, alanine aminotransferase (ALT), uric acid, PAI-1, fibrinogen and interleukin 6 (IL-6), and correlated negatively with apolipoprotein A-I and high-density lipoprotein cholesterol (HDL-C). Uric Acid 137-146 C-reactive protein Homo sapiens 0-3
16312915-1 2005 OBJECTIVES: We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases METHODS: We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-cholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. Uric Acid 394-403 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 227-230
16312915-5 2005 CONCLUSIONS: Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. Uric Acid 126-135 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 19-22
15656940-4 2005 Uricase reaction curve was simulated with random absorbance error of 0.001 at 0.075 mmol/l uric acid. Uric Acid 91-100 urate oxidase (pseudogene) Homo sapiens 0-7
17282161-3 2005 For UA sensors, uricase was immobilized on the surface of electrodes together with potassium ferrocyanide as electron transfer mediator. Uric Acid 4-6 urate oxidase (pseudogene) Homo sapiens 16-23
16375736-2 2005 The final two reactions of its production catalyzing the conversion of hypoxanthine to xanthine and the latter to uric acid are catalysed by the enzyme xanthine oxidoreductase, which may attain two inter-convertible forms, namely xanthine dehydrogenase or xanthine oxidase. Uric Acid 114-123 xanthine dehydrogenase Homo sapiens 152-175
16375736-2 2005 The final two reactions of its production catalyzing the conversion of hypoxanthine to xanthine and the latter to uric acid are catalysed by the enzyme xanthine oxidoreductase, which may attain two inter-convertible forms, namely xanthine dehydrogenase or xanthine oxidase. Uric Acid 114-123 xanthine dehydrogenase Homo sapiens 230-252
16375736-6 2005 Also, allopurinol, a xanthine oxidoreductase inhibitor that lowers serum levels of uric acid exerts protective effects in situations associated with oxidative stress (e.g. ischaemia-reperfusion injury, cardiovascular disease). Uric Acid 83-92 xanthine dehydrogenase Homo sapiens 21-44
15626645-8 2005 Next, in models of renal function in all workers, uric acid was significantly (p < 0.05) associated with all renal outcomes except NAG. Uric Acid 50-59 N-acetyl-alpha-glucosaminidase Homo sapiens 134-137
16532680-5 2005 All 5 samples from each man were included in multiple regression analysis and the prediction equation obtained was: serum gastrin, pg/mL = 198.27-0.199 total cholesterol (mg/dL) + 2.525 urea (mg/dL)--103.238 uric acid (mg/dL) + 10.923 uric acid (mg/dL)2 + 3.683 body mass index, r2 = 0.75, P < 0.001. Uric Acid 235-244 gastrin Homo sapiens 122-129
15958795-2 2005 Whereas high levels of uric acid are known to be caused by the silencing of the urate oxidase (uox) gene in humans and higher primates, the molecular basis for the Dalmatian defect is unknown. Uric Acid 23-32 urate oxidase (pseudogene) Homo sapiens 80-93
15642687-2 2005 We reviewed the data of 26 children with malignancy at risk for TLS who received rasburicase for treatment or prophylaxis of acute hyperuricemia, producing a significant decrease in uric acid level in all the patients. Uric Acid 182-191 FUS RNA binding protein Homo sapiens 64-67
15958795-2 2005 Whereas high levels of uric acid are known to be caused by the silencing of the urate oxidase (uox) gene in humans and higher primates, the molecular basis for the Dalmatian defect is unknown. Uric Acid 23-32 urate oxidase (pseudogene) Homo sapiens 95-98
15630733-1 2005 OBJECTIVE: To determine the effect of the tumor necrosis factor-alpha blocker etanercept on the pathergy and monosodium urate (MSU) status and on the mucocutaneous and articular manifestations of patients with Behcet"s disease (BD). Uric Acid 109-125 tumor necrosis factor Homo sapiens 42-69
15630733-1 2005 OBJECTIVE: To determine the effect of the tumor necrosis factor-alpha blocker etanercept on the pathergy and monosodium urate (MSU) status and on the mucocutaneous and articular manifestations of patients with Behcet"s disease (BD). Uric Acid 127-130 tumor necrosis factor Homo sapiens 42-69
16989162-1 2005 UNLABELLED: Previous studies showed that uric acid (UA) excretion in urine is increased in OSA patients and normalized after CPAP therapy. Uric Acid 41-50 centromere protein J Homo sapiens 125-129
15773552-4 2005 Further, to identify the ROS family members implicated in the HOX-1 induction, we also exposed cells to various non-thiol antioxidants: dimethyl sulfoxide, dimetylthiourea, sodium salicylate, sodium formate, uric acid, catalase, and superoxide dismutase. Uric Acid 208-217 heme oxygenase 1 Homo sapiens 62-67
15572382-19 2005 Serum uric acid may have an independent role in development of tubulointerstitial lesions as well as being associated with inflammation in renal tissue of patients with IgAN. Uric Acid 6-15 IGAN1 Homo sapiens 169-173
16989162-1 2005 UNLABELLED: Previous studies showed that uric acid (UA) excretion in urine is increased in OSA patients and normalized after CPAP therapy. Uric Acid 52-54 centromere protein J Homo sapiens 125-129
15562214-4 2004 Levels of ferritin, uric acid, white cell counts, fibrinogen, and C-reactive protein were significantly higher in individuals with a higher HOMA of insulin resistance (HOMA-IR). Uric Acid 20-29 insulin Homo sapiens 148-155
15660328-4 2005 Specifically, we review the evidence that the mutation of uricase that occurred in the Miocene that resulted in a higher serum uric acid in humans compared with most other mammals may have occurred as a means to increase blood pressure in early hominoids in response to a low-sodium and low-purine diet. Uric Acid 127-136 urate oxidase (pseudogene) Homo sapiens 58-65
15660333-5 2005 Possible adverse effects of uric acid on the vasculature have been linked to increased chemokine and cytokine expression, induction of the renin-angiotensin system, and to increased vascular C-reactive protein (CRP) expression. Uric Acid 28-37 renin Homo sapiens 139-144
15660333-5 2005 Possible adverse effects of uric acid on the vasculature have been linked to increased chemokine and cytokine expression, induction of the renin-angiotensin system, and to increased vascular C-reactive protein (CRP) expression. Uric Acid 28-37 C-reactive protein Homo sapiens 191-209
15660333-5 2005 Possible adverse effects of uric acid on the vasculature have been linked to increased chemokine and cytokine expression, induction of the renin-angiotensin system, and to increased vascular C-reactive protein (CRP) expression. Uric Acid 28-37 C-reactive protein Homo sapiens 211-214
15689106-0 2004 Effect of urate on the lactoperoxidase catalyzed oxidation of adrenaline. Uric Acid 10-15 lactoperoxidase Homo sapiens 23-38
15689106-5 2004 Lactoperoxidase was able to catalyze the oxidation of urate. Uric Acid 54-59 lactoperoxidase Homo sapiens 0-15
15581807-9 2004 The significantly increased plasma nonenzymatic antioxidants (uric acid [UA] and total antioxidant capacity) in concert with the enhanced enzymatic antioxidant activity (SOD in heart) during short-term CORT administration indicate preventive changes to counteract the oxidative injury, and these may be tissue specific. Uric Acid 62-71 CORT Gallus gallus 202-206
15581807-9 2004 The significantly increased plasma nonenzymatic antioxidants (uric acid [UA] and total antioxidant capacity) in concert with the enhanced enzymatic antioxidant activity (SOD in heart) during short-term CORT administration indicate preventive changes to counteract the oxidative injury, and these may be tissue specific. Uric Acid 73-75 CORT Gallus gallus 202-206
15528468-1 2004 Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Uric Acid 128-137 xanthine dehydrogenase Mus musculus 0-23
15579741-10 2004 Furthermore, affected individuals displayed hypouricemia with increased fractional excretion of uric acid, suggesting possible involvement of PTH in the renal handling of this metabolite. Uric Acid 96-105 parathyroid hormone Homo sapiens 142-145
15528468-1 2004 Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Uric Acid 128-137 xanthine dehydrogenase Mus musculus 25-28
15528468-8 2004 Finally, we show that in vitro and in vivo, uric acid can stimulate basal COX-2 expression. Uric Acid 44-53 prostaglandin-endoperoxide synthase 2 Mus musculus 74-79
15458439-3 2004 We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II. Uric Acid 40-49 angiotensinogen Homo sapiens 104-110
15566944-4 2004 The sex hormone testosterone significantly increases promoter activity, suggesting that hormonal regulation of hURAT1 is the root cause of observed differences in urate levels between males and females. Uric Acid 163-168 solute carrier family 22 member 12 Homo sapiens 111-117
15459594-6 2004 RESULTS: Baseline serum uric acid levels correlated positively with the body mass index, serum insulin, creatinine, and triglyceride levels and inversely with serum HDL cholesterol levels. Uric Acid 24-33 insulin Homo sapiens 95-102
15342194-2 2004 ICAM-1 upregulation in the spinal cord tissues of myelin basic protein (MBP) immunized mice is selectively inhibited by UA treatment. Uric Acid 120-122 intercellular adhesion molecule 1 Mus musculus 0-6
15342194-2 2004 ICAM-1 upregulation in the spinal cord tissues of myelin basic protein (MBP) immunized mice is selectively inhibited by UA treatment. Uric Acid 120-122 myelin basic protein Mus musculus 50-70
15342194-2 2004 ICAM-1 upregulation in the spinal cord tissues of myelin basic protein (MBP) immunized mice is selectively inhibited by UA treatment. Uric Acid 120-122 myelin basic protein Mus musculus 72-75
15342194-4 2004 Moreover, TNF-alpha expression in the CNS tissues of MBP-immunized mice is suppressed by UA treatment but TNF-alpha-induced ICAM-1 expression on neurovascular endothelial cells is not. Uric Acid 89-91 tumor necrosis factor Mus musculus 10-19
15342194-4 2004 Moreover, TNF-alpha expression in the CNS tissues of MBP-immunized mice is suppressed by UA treatment but TNF-alpha-induced ICAM-1 expression on neurovascular endothelial cells is not. Uric Acid 89-91 myelin basic protein Mus musculus 53-56
15342194-5 2004 Therefore the effect of UA on ICAM-1 upregulation in the CNS tissues is likely due to its known contribution to the maintenance of BBB integrity in MBP-immunized mice which in turn inhibits cell invasion into the CNS and prevents TNF-alpha production in CNS tissues. Uric Acid 24-26 intercellular adhesion molecule 1 Mus musculus 30-36
15342194-5 2004 Therefore the effect of UA on ICAM-1 upregulation in the CNS tissues is likely due to its known contribution to the maintenance of BBB integrity in MBP-immunized mice which in turn inhibits cell invasion into the CNS and prevents TNF-alpha production in CNS tissues. Uric Acid 24-26 myelin basic protein Mus musculus 148-151
15458439-8 2004 RESULTS: Uric acid concentration negatively correlated with the RPF response to Ang II (r=-0.37, P < 0.001). Uric Acid 9-18 angiotensinogen Homo sapiens 80-86
15458439-10 2004 In multivariable analysis, serum uric acid concentration independently predicted the RPF response to Ang II (beta=-5.3, P < 0.001). Uric Acid 33-42 angiotensinogen Homo sapiens 101-107
15458439-11 2004 CONCLUSION: Serum uric acid independently predicted blunted renal vascular responsiveness to Ang II, consistent with results from experimental hyperuricemia showing an activated intrarenal RAS. Uric Acid 18-27 angiotensinogen Homo sapiens 93-99
15566969-4 2004 Gouty crystals monosodium urate (MSU) appeared to up-regulate inducible nitric oxide synthase (iNOS) mRNA and protein expression in a concentration- and time-dependent manner in RAW264.7 macrophages. Uric Acid 15-31 nitric oxide synthase 2 Homo sapiens 95-99
15566969-4 2004 Gouty crystals monosodium urate (MSU) appeared to up-regulate inducible nitric oxide synthase (iNOS) mRNA and protein expression in a concentration- and time-dependent manner in RAW264.7 macrophages. Uric Acid 33-36 nitric oxide synthase 2 Homo sapiens 95-99
15304510-1 2004 The urate-anion exchanger URAT1 is a member of the organic anion transporter (OAT) family that regulates blood urate level in humans and is targeted by uricosuric and antiuricosuric agents. Uric Acid 4-9 solute carrier family 22 member 12 Homo sapiens 26-31
15304510-2 2004 URAT1 is expressed only in the kidney, where it is thought to participate in tubular urate reabsorption. Uric Acid 85-90 solute carrier family 22 member 12 Homo sapiens 0-5
15304510-7 2004 The association of URAT1 with PDZK1 enhanced urate transport activities in HEK293 cells (1.4-fold), and the deletion of the URAT1 C-terminal PDZ motif abolished this effect. Uric Acid 45-50 solute carrier family 22 member 12 Homo sapiens 19-24
15304510-7 2004 The association of URAT1 with PDZK1 enhanced urate transport activities in HEK293 cells (1.4-fold), and the deletion of the URAT1 C-terminal PDZ motif abolished this effect. Uric Acid 45-50 PDZ domain containing 1 Homo sapiens 30-35
15304510-8 2004 The augmentation of the transport activity was accompanied by a significant increase in the V(max) of urate transport via URAT1 and was associated with the increased surface expression level of URAT1 protein from HEK293 cells stably expressing URAT1 transfected with PDZK1. Uric Acid 102-107 solute carrier family 22 member 12 Homo sapiens 122-127
15304510-8 2004 The augmentation of the transport activity was accompanied by a significant increase in the V(max) of urate transport via URAT1 and was associated with the increased surface expression level of URAT1 protein from HEK293 cells stably expressing URAT1 transfected with PDZK1. Uric Acid 102-107 solute carrier family 22 member 12 Homo sapiens 194-199
15304510-8 2004 The augmentation of the transport activity was accompanied by a significant increase in the V(max) of urate transport via URAT1 and was associated with the increased surface expression level of URAT1 protein from HEK293 cells stably expressing URAT1 transfected with PDZK1. Uric Acid 102-107 solute carrier family 22 member 12 Homo sapiens 194-199
15304510-8 2004 The augmentation of the transport activity was accompanied by a significant increase in the V(max) of urate transport via URAT1 and was associated with the increased surface expression level of URAT1 protein from HEK293 cells stably expressing URAT1 transfected with PDZK1. Uric Acid 102-107 PDZ domain containing 1 Homo sapiens 267-272
15304510-9 2004 Taken together, the present study indicates the novel role of PDZK1 in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules. Uric Acid 124-129 PDZ domain containing 1 Homo sapiens 62-67
15304510-9 2004 Taken together, the present study indicates the novel role of PDZK1 in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules. Uric Acid 124-129 solute carrier family 22 member 12 Homo sapiens 109-114
16295051-8 2004 Multiple regression analysis revealed that age and uric acid concentrations were significant independent predictors of SHBG concentrations in the whole group (regression summary, adjusted r2=0.1414, F=10.5627, p<0.001). Uric Acid 51-60 sex hormone binding globulin Homo sapiens 119-123
15342194-5 2004 Therefore the effect of UA on ICAM-1 upregulation in the CNS tissues is likely due to its known contribution to the maintenance of BBB integrity in MBP-immunized mice which in turn inhibits cell invasion into the CNS and prevents TNF-alpha production in CNS tissues. Uric Acid 24-26 tumor necrosis factor Mus musculus 230-239
15378162-8 2004 With adjustment for covariables, GEE analyses of single genes demonstrated that serum uric acid, but not serum creatinine, was positively associated with the ACE D allele. Uric Acid 86-95 angiotensin I converting enzyme Homo sapiens 158-161
15378162-10 2004 Further GEE analyses of the three genes combined showed that the association between serum uric acid and the ACE polymorphism was confined to carriers of the alpha-adducin Gly and/or aldosterone synthase C alleles. Uric Acid 91-100 angiotensin I converting enzyme Homo sapiens 109-112
15378162-10 2004 Further GEE analyses of the three genes combined showed that the association between serum uric acid and the ACE polymorphism was confined to carriers of the alpha-adducin Gly and/or aldosterone synthase C alleles. Uric Acid 91-100 adducin 1 Homo sapiens 158-171
15378162-10 2004 Further GEE analyses of the three genes combined showed that the association between serum uric acid and the ACE polymorphism was confined to carriers of the alpha-adducin Gly and/or aldosterone synthase C alleles. Uric Acid 91-100 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 183-203
15378162-12 2004 Among 114 informative offspring carrying the alpha-adducin Gly allele serum uric acid was significantly and positively associated with the transmission of the ACE D allele (beta=20.7 micromol/l). Uric Acid 76-85 adducin 1 Homo sapiens 45-58
15378162-12 2004 Among 114 informative offspring carrying the alpha-adducin Gly allele serum uric acid was significantly and positively associated with the transmission of the ACE D allele (beta=20.7 micromol/l). Uric Acid 76-85 angiotensin I converting enzyme Homo sapiens 159-162
15458439-6 2004 Multivariable regression analysis determined if the serum uric acid concentration independently predicts the RPF response to Ang II. Uric Acid 58-67 angiotensinogen Homo sapiens 125-131
15493112-2 2004 Uric acid is the last stage in purine degradation, because humans lack the enzyme uricase which converts uric acid into allantoin. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 82-89
15571230-1 2004 We have examined whether hyperuricemia in essential hypertension may be related to an increased insulin secretion thereby enhancing the tubular reabsorption of sodium and thus uric acid. Uric Acid 176-185 insulin Homo sapiens 96-103
15571230-5 2004 These results suggest that insulin may mediate uric acid underexcretion due to its tubular sodium retaining effect in essential hypertensive patients. Uric Acid 47-56 insulin Homo sapiens 27-34
15571231-0 2004 Urate oxidation in CSF and blood of patients with inflammatory disorders of the nervous system. Uric Acid 0-5 colony stimulating factor 2 Homo sapiens 19-22
15571231-1 2004 Urate is largely excluded from the brain under non-inflammatory conditions (concentration gradient serum:CSF about 10:1), but increases markedly in Guillain-Barre Syndrome and bacterial meningitis. Uric Acid 0-5 colony stimulating factor 2 Homo sapiens 105-108
15486812-4 2004 The model simplifies purine nucleotide metabolism to four main steps: 1) de novo synthesis from PRPP to IMP; 2) the inosinic branch point from IMP to GMP or AMP; 3) catabolism of IMP, AMP and GMP to uric acid; 4) RNA and DNA formation from AMP and GMP. Uric Acid 199-208 inositol monophosphatase 2 Rattus norvegicus 104-110
15374618-3 2004 In a previous study, uric acid-generated superoxide anion was identified as one of the physiologically relevant inactivators of alpha2M S.A. Khan, F.H. Uric Acid 21-30 alpha-2-macroglobulin Homo sapiens 128-135
15363853-0 2004 Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage. Uric Acid 51-60 zinc finger protein 365 Homo sapiens 13-20
15363853-1 2004 Recently, we identified a susceptibility locus for human uric acid nephrolithiasis (UAN) on 10q21-q22 and demonstrated that a novel gene (ZNF365) included in this region produces through alternative splicing several transcripts coding for four protein isoforms. Uric Acid 57-66 zinc finger protein 365 Homo sapiens 138-144
15621715-3 2004 Cu(2+)-mediated inactivation of PON1 was enhanced remarkably by catecholamines, but not by uric acid or homocysteine. Uric Acid 91-100 paraoxonase 1 Homo sapiens 32-36
15493112-2 2004 Uric acid is the last stage in purine degradation, because humans lack the enzyme uricase which converts uric acid into allantoin. Uric Acid 105-114 urate oxidase (pseudogene) Homo sapiens 82-89
15493112-8 2004 In the kidney, uric acid is reabsorbed via the uric acid transporter URAT1. Uric Acid 15-24 solute carrier family 22 member 12 Homo sapiens 69-74
15265074-3 2004 Uricase, the enzyme involved in the breakdown of urate into allantoin, has been shown to function in Dalmatian liver cells. Uric Acid 49-54 urate oxidase Canis lupus familiaris 0-7
15289304-3 2004 We show here that uric acid levels are elevated in tumors undergoing immune rejection and that the inhibition of uric acid production, by systemic administration of allopurinol, or the removal of uric acid, by administration of uricase, delayed tumor immune rejection, whereas subcutaneous administration of crystalline uric acid enhanced the rejection process. Uric Acid 18-27 urate oxidase (pseudogene) Homo sapiens 228-235
15289304-3 2004 We show here that uric acid levels are elevated in tumors undergoing immune rejection and that the inhibition of uric acid production, by systemic administration of allopurinol, or the removal of uric acid, by administration of uricase, delayed tumor immune rejection, whereas subcutaneous administration of crystalline uric acid enhanced the rejection process. Uric Acid 113-122 urate oxidase (pseudogene) Homo sapiens 228-235
15289304-3 2004 We show here that uric acid levels are elevated in tumors undergoing immune rejection and that the inhibition of uric acid production, by systemic administration of allopurinol, or the removal of uric acid, by administration of uricase, delayed tumor immune rejection, whereas subcutaneous administration of crystalline uric acid enhanced the rejection process. Uric Acid 113-122 urate oxidase (pseudogene) Homo sapiens 228-235
15289304-3 2004 We show here that uric acid levels are elevated in tumors undergoing immune rejection and that the inhibition of uric acid production, by systemic administration of allopurinol, or the removal of uric acid, by administration of uricase, delayed tumor immune rejection, whereas subcutaneous administration of crystalline uric acid enhanced the rejection process. Uric Acid 113-122 urate oxidase (pseudogene) Homo sapiens 228-235
15107458-0 2004 Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils. Uric Acid 0-28 S100 calcium binding protein A8 Homo sapiens 88-94
15292348-9 2004 In obese children, adiponectin levels were closely associated with parameters related to the metabolic syndrome, such as insulin resistance, hyperinsulinemia, blood pressure, and uric acid, in univariate and multivariate analyses, with the insulin sensitivity index being the strongest independent parameter identified by stepwise forward multiple regression (r(2) = 0.226; P < 0.0001). Uric Acid 179-188 adiponectin, C1Q and collagen domain containing Homo sapiens 19-30
15284287-7 2004 In addition, the basal-to-apical transport of benzylpenicillin and urate was 3- and 2.5-fold greater than that in the opposite direction in the double-transfected cells, respectively, whereas their transepithelial transport in vector- or rOat3-LLC was symmetrical. Uric Acid 67-72 solute carrier family 22 member 8 Rattus norvegicus 238-243
15201549-2 2004 Xanthine oxidoreductase (XOR) produces urate and, in its oxidase isoform, reactive oxygen species also. Uric Acid 39-44 xanthine dehydrogenase Rattus norvegicus 0-23
15248227-0 2004 Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation. Uric Acid 76-104 transforming growth factor beta 1 Homo sapiens 22-54
15139009-4 2004 Further, superoxide dismutase plus catalase and uric acid strongly inhibit hypoosmotic PTN, suggesting the involvement of the toxic metabolite peroxynitrite (ONOO-) as a nitrating agent. Uric Acid 48-57 pleiotrophin Rattus norvegicus 87-90
15201549-2 2004 Xanthine oxidoreductase (XOR) produces urate and, in its oxidase isoform, reactive oxygen species also. Uric Acid 39-44 xanthine dehydrogenase Rattus norvegicus 25-28
15154943-8 2004 There was a positive correlation of CRP with body mass index (BMI), triglycerides, uric acid, fasting glucose, oral glucose tolerance test (OGTT) 1-h glucose, OGTT 2-h glucose, and a negative correlation with HDL cholesterol. Uric Acid 83-92 C-reactive protein Homo sapiens 36-39
15235923-13 2004 Renal epithelial cells exposed to uric acid crystals synthesize MCP-1 as well as PGE2. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 64-69
15235923-14 2004 Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8. Uric Acid 36-41 tumor necrosis factor Homo sapiens 59-86
15235923-14 2004 Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8. Uric Acid 36-41 interleukin 6 Homo sapiens 110-114
15235923-14 2004 Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8. Uric Acid 36-41 C-X-C motif chemokine ligand 8 Homo sapiens 120-124
15200452-4 2004 The TGF-beta1 (codon 25) CG genotype was detected more frequently in patients with normal uric acid levels. Uric Acid 90-99 transforming growth factor beta 1 Homo sapiens 4-13
15171478-1 2004 An alginate microcapsule was developed that contains three enzymes (urease, uricase, and creatininase) capable of effectively degrading urea, uric acid, and creatinine, which are elevated to pathologic levels in patients with kidney failure. Uric Acid 142-151 urate oxidase (pseudogene) Homo sapiens 76-83
15206151-3 2004 Hyperinsulinemia induced by insulin resistance reduces uric acid clearance, leading to hyperuricemia. Uric Acid 55-64 insulin Homo sapiens 5-12
15228653-8 2004 The expression of P27(Kip1) protein appeared nothing to do with sex, age, white blood cell number, blast cell number in peripheral blood, serum LDH or uric acid. Uric Acid 151-160 cyclin dependent kinase inhibitor 1B Homo sapiens 18-26
15100320-0 2004 Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B. Uric Acid 0-16 mitogen-activated protein kinase 3 Homo sapiens 103-144
15100320-0 2004 Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B. Uric Acid 0-16 nuclear factor kappa B subunit 1 Homo sapiens 149-159
15100320-2 2004 Monosodium urate (MSU) crystals, the causative agent of gout, have been shown to induce NO generation in vivo and inducible NO synthase (iNOS) expression in human monocytes. Uric Acid 0-16 nitric oxide synthase 2 Homo sapiens 114-135
15100320-2 2004 Monosodium urate (MSU) crystals, the causative agent of gout, have been shown to induce NO generation in vivo and inducible NO synthase (iNOS) expression in human monocytes. Uric Acid 0-16 nitric oxide synthase 2 Homo sapiens 137-141
15100320-2 2004 Monosodium urate (MSU) crystals, the causative agent of gout, have been shown to induce NO generation in vivo and inducible NO synthase (iNOS) expression in human monocytes. Uric Acid 18-21 nitric oxide synthase 2 Homo sapiens 114-135
15100320-2 2004 Monosodium urate (MSU) crystals, the causative agent of gout, have been shown to induce NO generation in vivo and inducible NO synthase (iNOS) expression in human monocytes. Uric Acid 18-21 nitric oxide synthase 2 Homo sapiens 137-141
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 34-39
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15086484-2 2004 Uric acid nephrolithiasis, a condition associated with a low urinary pH, has been linked to obesity and insulin resistance. Uric Acid 0-9 insulin Homo sapiens 104-111
15086484-11 2004 The results confirm the previously proposed scheme that obesity may sometimes cause uric acid nephrolithiasis by producing excessively acid urine due to insulin resistance. Uric Acid 84-93 insulin Homo sapiens 153-160
15319168-0 2004 Relation between the tumor necrosis factor-alpha (TNF-alpha) gene and protein expression, and clinical, biochemical, and genetic markers: age, body mass index and uric acid are independent predictors for an elevated TNF-alpha plasma level in a complex risk model. Uric Acid 163-172 tumor necrosis factor Homo sapiens 21-48
15319168-0 2004 Relation between the tumor necrosis factor-alpha (TNF-alpha) gene and protein expression, and clinical, biochemical, and genetic markers: age, body mass index and uric acid are independent predictors for an elevated TNF-alpha plasma level in a complex risk model. Uric Acid 163-172 tumor necrosis factor Homo sapiens 50-59
15319168-0 2004 Relation between the tumor necrosis factor-alpha (TNF-alpha) gene and protein expression, and clinical, biochemical, and genetic markers: age, body mass index and uric acid are independent predictors for an elevated TNF-alpha plasma level in a complex risk model. Uric Acid 163-172 tumor necrosis factor Homo sapiens 216-225
15082892-0 2004 The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men. Uric Acid 81-90 methylenetetrahydrofolate reductase Homo sapiens 21-57
15082892-8 2004 However, the relationship between the MTHFR mutation and uric acid metabolism remains unclear. Uric Acid 57-66 methylenetetrahydrofolate reductase Homo sapiens 38-43
15082892-9 2004 Therefore, further studies are necessary to explain the associated between the MTHFR mutation and elevated uric acid levels, and to examine potential relationships between it and conventional cardiovascular risk factors. Uric Acid 107-116 methylenetetrahydrofolate reductase Homo sapiens 79-84
15086454-11 2004 The hyperuricemia of the immature UUO animals was avoided by an increase in the clearance of uric acid in the UUO + ACE-treated group. Uric Acid 93-102 angiotensin I converting enzyme Rattus norvegicus 116-119
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. Uric Acid 285-290 solute carrier family 22 member 6 Homo sapiens 46-51
15046624-8 2004 There was a strong negative correlation between uric acid and PON1 in predialysis blood samples (r2 = 0.4, P < 0.001). Uric Acid 48-57 paraoxonase 1 Homo sapiens 62-66
14694147-3 2004 XOR is a member of the molybdoenzyme family and is best known for its catalytic role in purine degradation, metabolizing hypoxanthine and xanthine to uric acid with concomitant generation of superoxide. Uric Acid 150-159 xanthine dehydrogenase Homo sapiens 0-3
15046624-9 2004 The conclusion is that the reciprocal relationship between uric acid and PON1 may reflect a mechanism that protects erythrocytes from subsequent oxidative stress. Uric Acid 59-68 paraoxonase 1 Homo sapiens 73-77
15202612-5 2004 RECENT FINDINGS: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Uric Acid 93-102 insulin Homo sapiens 123-130
14871461-1 2004 BACKGROUND: In some western populations, increased serum uric acid has been positively associated with cardiovascular disease, possibly because hyperuricaemia could be an untoward part of the insulin-resistant metabolic syndrome. Uric Acid 57-66 insulin Homo sapiens 192-199
15129737-0 2004 Oxygen-copper (II) interplay in the repair of semi-oxidized urate by quercetin bound to human serum albumin. Uric Acid 60-65 albumin Homo sapiens 94-107
15002065-0 2004 Healthy subjects carrying the G protein beta3 subunit 825T-allele exhibit higher uric acid serum levels. Uric Acid 81-90 G protein subunit beta 3 Homo sapiens 30-45
14730623-0 2004 Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Uric Acid 66-82 protein tyrosine kinase 2 beta Homo sapiens 0-30
14747372-4 2004 The K(m) and the V(max) values of RST-dependent urate transport were 1213 +/- 222 micro M and 268.8 +/- 38.0 pmol/oocyte per hr, respectively (n = 3). Uric Acid 48-53 solute carrier family 22 member 12 Homo sapiens 34-37
14747372-5 2004 RST-dependent urate transport was cis-inhibited significantly by 1 mM probenecid (68.7 +/- 9.4%), 50 micro M benzbromarone (67.9 +/- 6.4%), and 10 mM lactate (50.9 +/- 9.5%). Uric Acid 14-19 solute carrier family 22 member 12 Homo sapiens 0-3
14747372-7 2004 Substitution of Cl anion with gluconate in the external solution enhanced RST-dependent urate transport. Uric Acid 88-93 solute carrier family 22 member 12 Homo sapiens 74-77
14747372-8 2004 Pre-injected pyrazinoic acid (PZA) or L-lactate trans-stimulated RST-dependent urate transport. Uric Acid 79-84 solute carrier family 22 member 12 Homo sapiens 65-68
14747372-13 2004 RST transported urate similar to hURAT1 and, therefore, appears to be mURAT1-the mouse homologue of hURAT1. Uric Acid 16-21 solute carrier family 22 member 12 Homo sapiens 0-3
14717908-3 2004 This study was designed to evaluate if insulin resistance is associated with excessively low urinary pH in overtly healthy volunteers (non-stone formers) and if insulin resistance may explain the excessively low urinary pH in patients with uric acid nephrolithiasis. Uric Acid 240-249 insulin Homo sapiens 161-168
14717908-8 2004 In addition to the previously described acidic urine pH and hypouricosuria, patients with recurrent uric acid nephrolithiasis were found to be severely insulin resistant (glucose disposal rate: uric acid stone-formers vs. normals; 4.1 +/- 1.3 vs. 6.9 +/- 2.1 mg/min/kg of lean body mass, P= 0.008). Uric Acid 100-109 insulin Homo sapiens 152-159
14717908-8 2004 In addition to the previously described acidic urine pH and hypouricosuria, patients with recurrent uric acid nephrolithiasis were found to be severely insulin resistant (glucose disposal rate: uric acid stone-formers vs. normals; 4.1 +/- 1.3 vs. 6.9 +/- 2.1 mg/min/kg of lean body mass, P= 0.008). Uric Acid 194-203 insulin Homo sapiens 152-159
14730623-0 2004 Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Uric Acid 66-82 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 35-38
14730623-11 2004 In this cascade, Pyk-2, Src, and p38 kinases transduce MSU-induced NO production and MMP-3 expression. Uric Acid 55-58 protein tyrosine kinase 2 beta Homo sapiens 17-22
14730623-11 2004 In this cascade, Pyk-2, Src, and p38 kinases transduce MSU-induced NO production and MMP-3 expression. Uric Acid 55-58 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 24-27
14730623-11 2004 In this cascade, Pyk-2, Src, and p38 kinases transduce MSU-induced NO production and MMP-3 expression. Uric Acid 55-58 mitogen-activated protein kinase 14 Homo sapiens 33-36
14730623-11 2004 In this cascade, Pyk-2, Src, and p38 kinases transduce MSU-induced NO production and MMP-3 expression. Uric Acid 55-58 matrix metallopeptidase 3 Homo sapiens 85-90
14704910-11 2004 The retinas preincubated with urate for 6 hours and exposed to SIN-1 for 16 hours showed significantly fewer TUNEL-positive cells compared to the retinas exposed to SIN-1 alone (p < 0.05). Uric Acid 30-35 MAPK associated protein 1 Homo sapiens 165-170
14727917-7 2004 To characterize the other system, experiments were performed first to determine the kinetics of hypoxanthine oxidation by xanthine oxidase and uric acid oxidation by uricase. Uric Acid 143-152 urate oxidase (pseudogene) Homo sapiens 166-173
14694169-2 2004 The authors recently established that urate was reabsorbed via URAT1 on the tubular apical membrane and that mutations in SLC22A12 encoding URAT1 cause renal hypouricemia. Uric Acid 38-43 solute carrier family 22 member 12 Homo sapiens 63-68
14706052-7 2004 There was a positive crude correlation between CRP and smoking, post-menopausal hormone use, body mass index, fasting glucose, triglycerides, hypertension, and uric acid (r = 0.11-0.36, P = 0.002-0.0001). Uric Acid 160-169 C-reactive protein Homo sapiens 47-50
14694169-2 2004 The authors recently established that urate was reabsorbed via URAT1 on the tubular apical membrane and that mutations in SLC22A12 encoding URAT1 cause renal hypouricemia. Uric Acid 38-43 solute carrier family 22 member 12 Homo sapiens 122-130
14694169-2 2004 The authors recently established that urate was reabsorbed via URAT1 on the tubular apical membrane and that mutations in SLC22A12 encoding URAT1 cause renal hypouricemia. Uric Acid 38-43 solute carrier family 22 member 12 Homo sapiens 140-145
14742850-9 2004 The plasma adiponectin levels were negatively related to BMI, FM, FM percentage, waist circumference, waist-to-hip ratio, insulin resistance, plasma insulin, triglycerides, and uric acid levels, but positively with high-density lipoprotein cholesterol (HDL-C) with the adjustment for age and gender. Uric Acid 177-186 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22
14655203-14 2003 Sequence analysis of a urate anion exchanger known to regulate blood urate level (URAT1 gene) in both brothers showed homozygous mutation in exon 4 (W258Stop), resulting in a premature truncated URAT1 protein. Uric Acid 23-28 solute carrier family 22 member 12 Homo sapiens 82-87
14664579-1 2003 Xanthine dehydrogenase (XDH) from the bacterium Rhodobacter capsulatus catalyzes the hydroxylation of xanthine to uric acid with NAD(+) as the electron acceptor. Uric Acid 114-123 xanthine dehydrogenase Homo sapiens 24-27
15277709-5 2004 Lesch-Nyhan disease is caused by a mutation in the HPRT1 gene that triggers an overproduction of uric acid, causing gout-like symptoms and urinary stones, in addition to neurological disorders. Uric Acid 97-106 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 51-56
15277709-6 2004 Due to biochemical differences between humans and rodents, a mouse lacking the HPRT expression will fail to accumulate uric acid. Uric Acid 119-128 hypoxanthine guanine phosphoribosyl transferase Mus musculus 79-83
15277709-9 2004 By using selection media, we show that HPRT1 activity is abolished in the mutant cells, and the HPRT1-cells show a higher rate of uric acid accumulation than the wild-type cells. Uric Acid 130-139 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 96-101
14655203-14 2003 Sequence analysis of a urate anion exchanger known to regulate blood urate level (URAT1 gene) in both brothers showed homozygous mutation in exon 4 (W258Stop), resulting in a premature truncated URAT1 protein. Uric Acid 23-28 solute carrier family 22 member 12 Homo sapiens 195-200
14578920-3 2003 In particular, ascorbate and urate scavenge peroxynitrite, which can alter the function of many molecules, including the lecithin-cholesterol acyltransferase (LCAT) enzyme involved in reverse cholesterol transport. Uric Acid 29-34 lecithin-cholesterol acyltransferase Homo sapiens 121-157
18969195-1 2003 Uricase (UOx) and polyelectrolyte were used for preparation of a permselective multilayer film and enzyme multilayer films on a platinum (Pt) electrode, allowing the detection of uric acid amperometrically. Uric Acid 179-188 urate oxidase (pseudogene) Homo sapiens 9-12
18969195-6 2003 Even in the presence of ascorbic acid, uric acid can be detected over the concentration range 10(-6)-10(-3) M. The response current and deposited amount of UOx were affected by deposition bath pH and the addition of salt. Uric Acid 39-48 urate oxidase (pseudogene) Homo sapiens 156-159
14578920-3 2003 In particular, ascorbate and urate scavenge peroxynitrite, which can alter the function of many molecules, including the lecithin-cholesterol acyltransferase (LCAT) enzyme involved in reverse cholesterol transport. Uric Acid 29-34 lecithin-cholesterol acyltransferase Homo sapiens 159-163
15107595-8 2003 The angiotensin-converting enzyme (ACE) inhibitors captopril, enalapril and ramipril have been found to increase uricosuria mildly, likely by lowering the net reabsorption of UA in the proximal tubule. Uric Acid 175-177 angiotensin I converting enzyme Homo sapiens 4-33
12953019-2 2003 To clarify the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the present longitudinal study. Uric Acid 39-48 leptin Homo sapiens 88-94
15107595-8 2003 The angiotensin-converting enzyme (ACE) inhibitors captopril, enalapril and ramipril have been found to increase uricosuria mildly, likely by lowering the net reabsorption of UA in the proximal tubule. Uric Acid 175-177 angiotensin I converting enzyme Homo sapiens 35-38
12920398-5 2003 These proteins have been localized to the basolateral membrane of proximal tubular cells: organic anion transporter 1 is an electroneutral organic anion exchanger; the mechanism of urate transport on organic anion transporter 3 remains to be determined. Uric Acid 181-186 solute carrier family 22 member 6 Homo sapiens 90-117
12920398-5 2003 These proteins have been localized to the basolateral membrane of proximal tubular cells: organic anion transporter 1 is an electroneutral organic anion exchanger; the mechanism of urate transport on organic anion transporter 3 remains to be determined. Uric Acid 181-186 solute carrier family 22 member 8 Homo sapiens 200-227
12920398-8 2003 Since organic anion transporters 1 and 3 reside in the basolateral membrane, one or both may be relevant in the reabsorptive flux of urate into the peritubular capillary as well as in the cellular uptake of urate from the peritubular space, the first step in the process of urate secretion. Uric Acid 133-138 solute carrier family 22 member 6 Homo sapiens 6-40
12920398-8 2003 Since organic anion transporters 1 and 3 reside in the basolateral membrane, one or both may be relevant in the reabsorptive flux of urate into the peritubular capillary as well as in the cellular uptake of urate from the peritubular space, the first step in the process of urate secretion. Uric Acid 207-212 solute carrier family 22 member 6 Homo sapiens 6-40
12920398-8 2003 Since organic anion transporters 1 and 3 reside in the basolateral membrane, one or both may be relevant in the reabsorptive flux of urate into the peritubular capillary as well as in the cellular uptake of urate from the peritubular space, the first step in the process of urate secretion. Uric Acid 207-212 solute carrier family 22 member 6 Homo sapiens 6-40
12905486-0 2003 Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Uric Acid 67-95 S100 calcium binding protein A8 (calgranulin A) Mus musculus 8-14
12972677-11 2003 The inverse correlations of adiponectin with alanine aminotransferase, uric acid, and insulin were significant after being adjusted for percentage overweight, percentage body fat, or sex. Uric Acid 71-80 adiponectin, C1Q and collagen domain containing Homo sapiens 28-39
14560659-4 2003 We identified the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted it with uricosuric and antiuricosuric agents. Uric Acid 36-41 solute carrier family 22 member 12 Homo sapiens 75-80
14560659-4 2003 We identified the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted it with uricosuric and antiuricosuric agents. Uric Acid 36-41 solute carrier family 22 member 12 Homo sapiens 93-101
12829005-1 2003 Lesch-Nyhan syndrome (LNS) is caused by a severe deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) and clinically characterized by self-injurious behavior and nephrolithiasis; the latter is treatable with allopurinol, an inhibitor of xanthine oxidase which converts xanthine and hypoxanthine into uric acid. Uric Acid 315-324 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 111-115
12847698-3 2003 Results of enzymatic and genetic studies supported the view that accelerated purine nucleotide and uric acid production in this woman resulted from defective allosteric regulation of PRS activity, which is, in turn, a consequence of a mutation in one of the patient"s PRPS1 genes: an A-to-T substitution at nucleotide 578, encoding leucine for histidine at amino acid residue 192 of the mature PRS1 isoform. Uric Acid 99-108 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 268-273
12906034-0 2003 Leptin might be a regulator of serum uric acid concentrations in humans. Uric Acid 37-46 leptin Homo sapiens 0-6
12858344-0 2003 Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages. Uric Acid 103-108 matrix metallopeptidase 9 Homo sapiens 94-99
12787393-8 2003 The cardinal clinical features in individuals with the uromodulin mutation included hyperuricemia, decreased fractional excretion of uric acid, and chronic interstitial renal disease leading to end-stage renal disease (ESRD) in the fifth through seventh decade. Uric Acid 133-142 uromodulin Homo sapiens 55-65
12906034-7 2003 On univariate correlation analysis, leptin showed the strongest association with BMI in both sexes and also correlated significantly with BMI, insulin, uric acid, glucose, total cholesterol, and triglycerides in males and BMI, insulin, uric acid, total cholesterol, apo B, and creatinine in females after adjustment for age and BMI. Uric Acid 236-245 leptin Homo sapiens 36-42
12906034-7 2003 On univariate correlation analysis, leptin showed the strongest association with BMI in both sexes and also correlated significantly with BMI, insulin, uric acid, glucose, total cholesterol, and triglycerides in males and BMI, insulin, uric acid, total cholesterol, apo B, and creatinine in females after adjustment for age and BMI. Uric Acid 152-161 leptin Homo sapiens 36-42
12787393-10 2003 CONCLUSION: Mutation of the uromodulin gene resulted in hyperuricemia, reduced fractional excretion of uric acid, and renal failure. Uric Acid 103-112 uromodulin Homo sapiens 28-38
12947532-9 2003 Finally, uric acid and fibrinogen were elevated in the eNOS-/- mice. Uric Acid 9-18 nitric oxide synthase 3, endothelial cell Mus musculus 55-59
12707250-1 2003 BACKGROUND: Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Uric Acid 18-27 forkhead box P1 Homo sapiens 123-126
12753597-4 2003 Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r(2) = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Uric Acid 184-193 elastase, neutrophil expressed Homo sapiens 0-19
12743010-0 2003 Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Uric Acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 21-55
12743010-0 2003 Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Uric Acid 0-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 140-156
12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 65-99
12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 101-106
12743010-4 2003 Increased mRNA and protein expression occurred as early as 3 hours after uric acid incubation and was partially dependent on posttranscriptional modification of MCP-1 mRNA. Uric Acid 73-82 C-C motif chemokine ligand 2 Homo sapiens 161-166
12743010-5 2003 In addition, uric acid activated the transcription factors nuclear factor-kappaB and activator protein-1, as well as the MAPK signaling molecules ERK p44/42 and p38, and increased cyclooxygenase-2 (COX-2) mRNA expression. Uric Acid 13-22 interferon induced protein 44 Homo sapiens 150-153
12743010-5 2003 In addition, uric acid activated the transcription factors nuclear factor-kappaB and activator protein-1, as well as the MAPK signaling molecules ERK p44/42 and p38, and increased cyclooxygenase-2 (COX-2) mRNA expression. Uric Acid 13-22 mitogen-activated protein kinase 14 Homo sapiens 161-164
12743010-5 2003 In addition, uric acid activated the transcription factors nuclear factor-kappaB and activator protein-1, as well as the MAPK signaling molecules ERK p44/42 and p38, and increased cyclooxygenase-2 (COX-2) mRNA expression. Uric Acid 13-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 180-196
12743010-5 2003 In addition, uric acid activated the transcription factors nuclear factor-kappaB and activator protein-1, as well as the MAPK signaling molecules ERK p44/42 and p38, and increased cyclooxygenase-2 (COX-2) mRNA expression. Uric Acid 13-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 198-203
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 mitogen-activated protein kinase 14 Homo sapiens 14-17
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 mitogen-activated protein kinase 1 Homo sapiens 36-39
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-80
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 C-C motif chemokine ligand 2 Homo sapiens 142-147
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 218-227 mitogen-activated protein kinase 14 Homo sapiens 14-17
12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 218-227 C-C motif chemokine ligand 2 Homo sapiens 142-147
12743010-7 2003 The ability of both n-acetyl-cysteine and diphenyleneionium (antioxidants) to inhibit uric acid-induced MCP-1 production suggested involvement of intracellular redox pathways. Uric Acid 86-95 C-C motif chemokine ligand 2 Homo sapiens 104-109
12732400-7 2003 Serum uric acid concentrations were higher in hypertensives with PAD (404+/-101 vs. 347+/-80 micromol/l, P<0.001) independent of components of the metabolic syndrome (body mass index, triglycerides, insulin) and of age, gender, diabetes mellitus, pulse pressure, cholesterol, C-reactive protein, and treatment. Uric Acid 6-15 insulin Homo sapiens 202-209
12732400-7 2003 Serum uric acid concentrations were higher in hypertensives with PAD (404+/-101 vs. 347+/-80 micromol/l, P<0.001) independent of components of the metabolic syndrome (body mass index, triglycerides, insulin) and of age, gender, diabetes mellitus, pulse pressure, cholesterol, C-reactive protein, and treatment. Uric Acid 6-15 C-reactive protein Homo sapiens 279-297
12675839-5 2003 We also compared serum urate levels in subjects with HNF-1beta mutations with populations of controls, type 2 diabetic subjects, and subjects with mild chronic renal failure without HNF-1beta mutations. Uric Acid 23-28 HNF1 homeobox A Homo sapiens 53-62
12675839-7 2003 Serum urate levels were significantly higher in the HNF-1beta subjects compared with the normal control subjects (384 micromol/L vs. 264 micromol/L, P = 0.002) and the type 2 diabetic subjects (397 micromol/L vs. 271 micromol/L, P = 0.01). Uric Acid 6-11 HNF1 homeobox A Homo sapiens 52-61
12689826-3 2003 The hypoxanthine is oxidized to uric acid by xanthine oxidase/xanthine dehydrogenase and can be measured by formation of formazan when a tetrazolium salt is used as the oxidant. Uric Acid 32-41 xanthine dehydrogenase Homo sapiens 62-84
12707250-1 2003 BACKGROUND: Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Uric Acid 29-31 forkhead box P1 Homo sapiens 123-126
12650690-1 2003 Normal silkworms (Bombyx mori) have opaque larval skin due to uric acid accumulation in the epidermis while a mutant, og, is translucent owing to a deficiency in xanthine dehydrogenase (XDH), which synthesizes uric acid. Uric Acid 210-219 xanthine dehydrogenase 1 Bombyx mori 162-184
12687558-1 2003 Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals. Uric Acid 118-123 prostaglandin-endoperoxide synthase 2 Homo sapiens 66-82
12650690-1 2003 Normal silkworms (Bombyx mori) have opaque larval skin due to uric acid accumulation in the epidermis while a mutant, og, is translucent owing to a deficiency in xanthine dehydrogenase (XDH), which synthesizes uric acid. Uric Acid 210-219 xanthine dehydrogenase 1 Bombyx mori 186-189
12637633-0 2003 Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Uric Acid 150-159 chemokine (C-C motif) ligand 2 Mus musculus 24-58
12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. Uric Acid 91-100 synaptophysin Rattus norvegicus 142-155
12637633-0 2003 Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Uric Acid 150-159 chemokine (C-C motif) ligand 2 Mus musculus 60-65
12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. Uric Acid 91-100 amyloid beta precursor protein Rattus norvegicus 224-229
12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. Uric Acid 102-104 synaptophysin Rattus norvegicus 142-155
12637633-3 2003 We investigated the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein by NRK52E rat renal tubular epithelial cells exposed to calcium oxalate (CaOx), brushite (Br, a calcium phosphate) and uric acid (UA) crystals. Uric Acid 213-222 C-C motif chemokine ligand 2 Rattus norvegicus 34-68
12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. Uric Acid 102-104 amyloid beta precursor protein Rattus norvegicus 224-229
12637633-3 2003 We investigated the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein by NRK52E rat renal tubular epithelial cells exposed to calcium oxalate (CaOx), brushite (Br, a calcium phosphate) and uric acid (UA) crystals. Uric Acid 224-226 C-C motif chemokine ligand 2 Rattus norvegicus 34-68
12611663-9 2003 However, after adjusting for other potential confounders, we found a significant linear relationship between serum uric acid and patella bone lead (p = 0.040) among the ALAD 1-2/2-2 genotype individuals above a threshold patellar lead level of 15 micro g/g. Uric Acid 115-124 aminolevulinate dehydratase Homo sapiens 169-173
12611663-10 2003 In contrast, among the wild-type (ALAD 1-1) individuals, there was a suggestion of a significant linear relationship of serum uric acid with patella bone lead (p = 0.141), but only after a threshold of 101 micro g/g. Uric Acid 126-135 aminolevulinate dehydratase Homo sapiens 34-38
12611663-13 2003 Our findings suggest that ALAD genotype may modify the effect of lead on the renal excretion of uric acid as well as overall renal function among middle-aged and elderly men who had community (nonoccupational) exposures to lead. Uric Acid 96-105 aminolevulinate dehydratase Homo sapiens 26-30
12619798-1 2003 Inhibition of microbial uricase in poultry manure is critical to reduce NH3 volatilization, because hydrolysis of uric acid by microbial uricase is the first step in the production of NH3 gas in poultry manure. Uric Acid 114-123 urate oxidase (pseudogene) Homo sapiens 24-31
12535843-1 2003 The XOR activity in human plasma was measured by quantifying the XOR-derived uric acid (UA) in plasma using the high-performance liquid chromatography (HPLC) equipped with a UV detector. Uric Acid 77-86 xanthine dehydrogenase Homo sapiens 4-7
12535843-1 2003 The XOR activity in human plasma was measured by quantifying the XOR-derived uric acid (UA) in plasma using the high-performance liquid chromatography (HPLC) equipped with a UV detector. Uric Acid 77-86 xanthine dehydrogenase Homo sapiens 65-68
12535843-1 2003 The XOR activity in human plasma was measured by quantifying the XOR-derived uric acid (UA) in plasma using the high-performance liquid chromatography (HPLC) equipped with a UV detector. Uric Acid 88-90 xanthine dehydrogenase Homo sapiens 4-7
12535843-1 2003 The XOR activity in human plasma was measured by quantifying the XOR-derived uric acid (UA) in plasma using the high-performance liquid chromatography (HPLC) equipped with a UV detector. Uric Acid 88-90 xanthine dehydrogenase Homo sapiens 65-68
12424096-6 2003 In isolated and pressurized small coronary arteries, N-vanillylnonanamide, apocynin, or uric acid, a peroxynitrite scavenger, largely restored the inhibitory effects of ceramide on bradykinin- and A-23187-induced vasorelaxation. Uric Acid 88-97 kininogen 1 Homo sapiens 181-191
12629136-8 2003 The results of our studies, which have identified the gene causing FJHN, now indicate a further, novel role for UROMODULIN in urate metabolism. Uric Acid 126-131 uromodulin Homo sapiens 112-122
12626798-8 2003 CONCLUSIONS: These results show that the reduced renal excretion of uric acid in patients with gout is mediated by high levels of VLDL and by the high prevalence of the E2 allele of apolipoprotein E. Uric Acid 68-77 apolipoprotein E Homo sapiens 182-198
12619798-1 2003 Inhibition of microbial uricase in poultry manure is critical to reduce NH3 volatilization, because hydrolysis of uric acid by microbial uricase is the first step in the production of NH3 gas in poultry manure. Uric Acid 114-123 urate oxidase (pseudogene) Homo sapiens 137-144
14586168-0 2003 Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Uric Acid 92-97 solute carrier family 22 member 8 Homo sapiens 6-33
12528124-0 2003 Rapid induction of peroxisome proliferator-activated receptor gamma expression in human monocytes by monosodium urate monohydrate crystals. Uric Acid 101-129 peroxisome proliferator activated receptor gamma Homo sapiens 19-67
12528124-3 2003 To do this, we investigated PPAR gamma expression by monosodium urate monohydrate (MSU) crystal-stimulated monocytes, and we studied the effects of PPAR gamma ligands on crystal-induced acute inflammation. Uric Acid 53-81 peroxisome proliferator activated receptor gamma Homo sapiens 28-38
12528124-3 2003 To do this, we investigated PPAR gamma expression by monosodium urate monohydrate (MSU) crystal-stimulated monocytes, and we studied the effects of PPAR gamma ligands on crystal-induced acute inflammation. Uric Acid 83-86 peroxisome proliferator activated receptor gamma Homo sapiens 28-38
14586168-0 2003 Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Uric Acid 92-97 solute carrier family 22 member 8 Homo sapiens 35-40
14586168-7 2003 RESULTS: hOAT3-mediated efflux of glutarate (GA), can be significantly trans-stimulated by a variety of ions with high cis-inhibitory potency, including GA (282%), alpha-ketoglutarate (476%), p-aminohippurate (179%), and, most notably, urate (167%). Uric Acid 203-208 solute carrier family 22 member 8 Homo sapiens 9-14
12472777-0 2003 Urate transport via human PAH transporter hOAT1 and its gene structure. Uric Acid 0-5 solute carrier family 22 member 6 Homo sapiens 42-47
23105367-0 2003 Quantification of urinary urate with alkylamine glass-bound uricase and arylamine glass-bound peroxidase. Uric Acid 26-31 urate oxidase (pseudogene) Homo sapiens 60-67
23105367-1 2003 Uric acid in urine was analyzed using porcine liver uricase and horseradish peroxidase immobilized on alkylamine and arylamine glass beads (pore diameter 55nm) respectively. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 52-59
12472777-4 2003 METHODS: To determine if hOAT1 transported urate, the cellular uptakes of PAH and urate were determined, as were the inhibition profiles of inorganic anions, and uricosuric and antiuricosuric agents using a mouse S2 cell line expressing hOAT1. Uric Acid 43-48 solute carrier family 22 member 6 Homo sapiens 25-30
12472777-8 2003 RESULTS: The Km and Vmax values of urate transport via hOAT1 were 943 +/- 84 micromol/L and 1286 +/- 162 pmol/mg protein/min, respectively. Uric Acid 35-40 solute carrier family 22 member 6 Homo sapiens 55-60
12472777-9 2003 The order of the IC50 of urate transport via hOAT1 was benzbromarone < probenecid < salicylate or pyrazine carboxylic acid. Uric Acid 25-30 solute carrier family 22 member 6 Homo sapiens 45-50
12472777-13 2003 CONCLUSIONS: Our data show that hOAT1 transports urate, and the inhibition profiles of uricosuric and antiuricosuric agents are defined. Uric Acid 49-54 solute carrier family 22 member 6 Homo sapiens 32-37
12451183-7 2002 Moreover, when mice treated with the urate oxidase inhibitor potassium oxonate were fed inosine or inosinic acid, serum UA levels were elevated markedly for a period of hours, whereas only a minor, transient increase in serum inosine was detected. Uric Acid 120-122 urate oxidase Mus musculus 37-50
12607260-0 2003 [Identification of a novel urate transporter URAT1 and current status on urate research]. Uric Acid 27-32 solute carrier family 22 member 12 Homo sapiens 45-50
12629726-0 2003 [Effect of hyperglycemia and insulin resistance on serum uric acid]. Uric Acid 57-66 insulin Homo sapiens 29-36
12629765-0 2003 [Interleukin 6 deduces serum urate concentration]. Uric Acid 29-34 interleukin 6 Homo sapiens 1-14
12455842-7 2002 Plasma uric acid concentrations were significantly reduced, suggesting downregulation of the xanthine-dehydrogenase and xanthine-oxydase pathway. Uric Acid 7-16 xanthine dehydrogenase/oxidase Equus caballus 93-115
12452799-4 2002 The immobilized enzyme retained 88% of its initial limit rate [V (max)(app)=16 EU/mg for immobilized uricase versus V (max)=18 EU/mg for the free enzyme], with an apparent decrease of affinity for urate substrate [K (m)(app)=0.17 mM versus K (m)=0.03 mM for the free enzyme]. Uric Acid 197-202 urate oxidase (pseudogene) Homo sapiens 101-108
12474637-5 2002 A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis. Uric Acid 203-212 insulin Homo sapiens 31-38
12444207-16 2002 In in vitro studies, cultured vascular smooth muscle cells incubated with uric acid also generated COX-2 with time-dependent proliferation, which was prevented by either a COX-2 or TXA-2 receptor inhibitor. Uric Acid 74-83 cytochrome c oxidase II, mitochondrial Rattus norvegicus 99-104
12444207-16 2002 In in vitro studies, cultured vascular smooth muscle cells incubated with uric acid also generated COX-2 with time-dependent proliferation, which was prevented by either a COX-2 or TXA-2 receptor inhibitor. Uric Acid 74-83 cytochrome c oxidase II, mitochondrial Rattus norvegicus 172-177
12367777-1 2002 BACKGROUND: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to uric acid, respectively. Uric Acid 223-232 adenosine deaminase Homo sapiens 12-31
12367777-1 2002 BACKGROUND: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to uric acid, respectively. Uric Acid 223-232 adenosine deaminase Homo sapiens 33-35
12398932-7 2002 However, accumulation of urate formed by the oxidation of hypoxanthine by xanthine dehydrogenase and oxidase in heart appeared to be the major inhibitor of nitration. Uric Acid 25-30 xanthine dehydrogenase Rattus norvegicus 74-96
12231557-0 2002 Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity. Uric Acid 69-78 superoxide dismutase 3, extracellular Mus musculus 25-59
12398932-10 2002 Although xanthine dehydrogenase conversion to a free radical-producing oxidase can serve as an important source of superoxide and hydrogen peroxide during ischemia/reperfusion, our results suggest that urate formation by xanthine dehydrogenase may provide a significant antioxidant defense against peroxynitrite and related nitric oxide-derived oxidants. Uric Acid 202-207 xanthine dehydrogenase Rattus norvegicus 9-31
12398932-10 2002 Although xanthine dehydrogenase conversion to a free radical-producing oxidase can serve as an important source of superoxide and hydrogen peroxide during ischemia/reperfusion, our results suggest that urate formation by xanthine dehydrogenase may provide a significant antioxidant defense against peroxynitrite and related nitric oxide-derived oxidants. Uric Acid 202-207 xanthine dehydrogenase Rattus norvegicus 221-243
12429873-4 2002 RESULTS: The plasma adiponectin levels negatively correlated with BMI, waist-to-hip ratio, fasting plasma glucose, insulin, triglyceride, uric acid levels, hyperinsulinemia, and glucose intolerance in OGTT, but positively with high-density lipoprotein-cholesterol. Uric Acid 138-147 adiponectin, C1Q and collagen domain containing Homo sapiens 20-31
12358504-6 2002 Uric acid strongly affects the results obtained by the TRAP test and does not affect those obtained by the crocin test. Uric Acid 0-9 TRAP Homo sapiens 55-59
12379764-4 2002 GROalpha level in the joints peaked at 2 hours after intra-articular injection of monosodium urate crystals, at a time before the neutrophil influx reached the maximal level (9 hours). Uric Acid 82-98 GRO alpha protein Oryctolagus cuniculus 0-8
12355499-0 2002 Antiinflammatory effect of retrovirally transfected interleukin-10 on monosodium urate monohydrate crystal-induced acute inflammation in murine air pouches. Uric Acid 70-98 interleukin 10 Mus musculus 52-66
12373573-9 2002 Ad-mG6Pase infusion also greatly improved growth of G6Pase(-/-) mice and normalized plasma glucose, cholesterol, triglyceride, and uric acid profiles. Uric Acid 131-140 glucose-6-phosphatase, catalytic Mus musculus 4-10
12231557-4 2002 SOD1 and SOD3 were inactivated by H2O2 in a dose- and time-dependent fashion, and this was prevented by physiological levels of uric acid. Uric Acid 128-137 superoxide dismutase 1, soluble Mus musculus 0-4
12231557-4 2002 SOD1 and SOD3 were inactivated by H2O2 in a dose- and time-dependent fashion, and this was prevented by physiological levels of uric acid. Uric Acid 128-137 superoxide dismutase 3, extracellular Mus musculus 9-13
12231557-6 2002 This treatment increased plasma levels of uric acid in control and ApoE(-/-) mice by approximately 3-fold. Uric Acid 42-51 apolipoprotein E Mus musculus 67-71
12231557-8 2002 CONCLUSIONS: These studies show that SOD1 and SOD3 are partially inactivated in atherosclerotic vessels of ApoE(-/-) mice and that levels of uric acid commonly encountered in vivo may regulate vascular redox state by preserving the activity of these enzymes. Uric Acid 141-150 superoxide dismutase 1, soluble Mus musculus 37-41
12231557-8 2002 CONCLUSIONS: These studies show that SOD1 and SOD3 are partially inactivated in atherosclerotic vessels of ApoE(-/-) mice and that levels of uric acid commonly encountered in vivo may regulate vascular redox state by preserving the activity of these enzymes. Uric Acid 141-150 superoxide dismutase 3, extracellular Mus musculus 46-50
12215479-1 2002 Humans have elevated serum uric acid as a result of a mutation in the urate oxidase (uricase) gene that occurred during the Miocene. Uric Acid 27-36 urate oxidase (pseudogene) Homo sapiens 85-92
12411100-0 2002 Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus. Uric Acid 82-91 glycogen synthase 1 Homo sapiens 15-19
12411100-0 2002 Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus. Uric Acid 82-91 adrenoceptor beta 3 Homo sapiens 24-34
12411100-9 2002 The presence of the Arg64 allele in the beta(3)-AR gene may predispose patients to higher serum uric acid level. Uric Acid 96-105 adrenoceptor beta 3 Homo sapiens 40-50
12215479-5 2002 The vascular disease is mediated in part by uric acid-induced smooth muscle cell proliferation with activation of mitogen-activated protein kinases and stimulation of cyclooxygenase-2 and platelet-derived growth factor. Uric Acid 44-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 167-183
12198383-3 2002 Except for them, the gamma-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. Uric Acid 98-107 inactive glutathione hydrolase 2 Homo sapiens 21-30
12160929-6 2002 Cotreatment of p53-WT H460 cells with free radical scavengers, such as D-mannitol, uric acid, and sodium selenite, significantly attenuated the TCE- or PERC-induced lipid peroxidation. Uric Acid 83-92 tumor protein p53 Homo sapiens 15-18
12163122-9 2002 Brain concentrations of proinflammatory cytokines [interleukin-1beta (IL-beta), interleukin-6 (IL-6), and macrophage inflammatory protein-2 (MIP-2)] were also reduced by urate and MnTBAP. Uric Acid 170-175 interleukin 1 beta Rattus norvegicus 51-68
12163122-9 2002 Brain concentrations of proinflammatory cytokines [interleukin-1beta (IL-beta), interleukin-6 (IL-6), and macrophage inflammatory protein-2 (MIP-2)] were also reduced by urate and MnTBAP. Uric Acid 170-175 interleukin 6 Rattus norvegicus 80-93
12163122-9 2002 Brain concentrations of proinflammatory cytokines [interleukin-1beta (IL-beta), interleukin-6 (IL-6), and macrophage inflammatory protein-2 (MIP-2)] were also reduced by urate and MnTBAP. Uric Acid 170-175 C-X-C motif chemokine ligand 2 Rattus norvegicus 106-139
12163122-9 2002 Brain concentrations of proinflammatory cytokines [interleukin-1beta (IL-beta), interleukin-6 (IL-6), and macrophage inflammatory protein-2 (MIP-2)] were also reduced by urate and MnTBAP. Uric Acid 170-175 C-X-C motif chemokine ligand 2 Rattus norvegicus 141-146
12176048-1 2002 Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8. Uric Acid 48-76 C-X-C motif chemokine ligand 8 Homo sapiens 179-183
12176048-1 2002 Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8. Uric Acid 78-82 C-X-C motif chemokine ligand 8 Homo sapiens 179-183
12160192-0 2002 Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Uric Acid 19-28 insulin Homo sapiens 48-55
12160192-8 2002 CONCLUSIONS: The amelioration of insulin resistance by either a low-energy diet or troglitazone decreased the serum UA level in overweight hypertensive patients. Uric Acid 116-118 insulin Homo sapiens 33-40
12160192-9 2002 Insulin resistance or hyperinsulinemia, independent of body weight and BP, may play an important role in UA metabolism in multiple risk factor syndrome. Uric Acid 105-107 insulin Homo sapiens 0-7
12104095-5 2002 The high uric acid levels in both patient groups might be partly responsible for the increment in FRAP values. Uric Acid 9-18 mechanistic target of rapamycin kinase Homo sapiens 98-102
12175817-6 2002 DFO (100 microm, 5-min preincubation) also restored the stimulatory effect of ANG II (1.40 +/- 0.08-fold; n = 4; P < 0.05, compared to 10(-7) M alone), as did UA (1.22 +/- 0.07-fold; n = 5; P < 0.05, compared to 10(-7) M alone). Uric Acid 162-164 angiotensinogen Rattus norvegicus 78-84
12149104-7 2002 The serum adiponectin level was negatively correlated with BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, insulin, HOMA-IR, total cholesterol, triacylglycerols, low-density lipoprotein (LDL)-cholesterol and uric acid, and positively correlated with high-density lipoprotein (HDL)-cholesterol. Uric Acid 240-249 adiponectin, C1Q and collagen domain containing Homo sapiens 10-21
12149104-8 2002 The correlations between serum adiponectin level and insulin, HOMA-IR, triacylglycerols, HDL-cholesterol, LDL-cholesterol and uric acid were significant even after adjustment for age, sex and BMI. Uric Acid 126-135 adiponectin, C1Q and collagen domain containing Homo sapiens 31-42
12124547-10 2002 Uric acid concentration was greater in G-2 at T-1, T-2, T-3 and T-4 than G-1 and catalase activity was higher in G-2 at T-0, T-2 and T-3 than G-1 with noteworthy difference only at 5 minutes after anoxic heart arrest. Uric Acid 0-9 catalase Homo sapiens 64-89
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 39-44 solute carrier family 22 member 12 Homo sapiens 78-83
12089173-8 2002 In addition, multiple logistic regression analysis showed that the frequencies of individuals whose systolic blood pressure, triglycerides, and uric acid values were in the highest one third were significantly higher in the ADH2(2)/2(2) group than in the ADH2(1)/2(1) group. Uric Acid 144-153 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 224-228
12089173-8 2002 In addition, multiple logistic regression analysis showed that the frequencies of individuals whose systolic blood pressure, triglycerides, and uric acid values were in the highest one third were significantly higher in the ADH2(2)/2(2) group than in the ADH2(1)/2(1) group. Uric Acid 144-153 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 255-259
12077737-3 2002 The fractional clearances of uric acid, xanthine, and oxypurinol were significantly decreased during angiotensin II infusion; however, that of hypoxanthine did not change. Uric Acid 29-38 angiotensinogen Homo sapiens 101-115
12077737-4 2002 The urinary excretion levels of uric acid, xanthine, and oxypurinol were also significantly decreased during angiotensin II infusion. Uric Acid 32-41 angiotensinogen Homo sapiens 109-123
12077737-5 2002 These results suggest that angiotensin II infusion affected the renal clearances of uric acid, xanthine, and oxypurinol through direct tubular transport and/or hemodynamic changes. Uric Acid 84-93 angiotensinogen Homo sapiens 27-41
12222668-2 2002 The present study was to test whether ingestion of OGT extract (TJ-15) would affect the metabolism of fatty acids and the usual antioxidant molecule (such as albumin, uric acid and bilirubin) levels in human plasma. Uric Acid 167-176 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 51-54
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 39-44 solute carrier family 22 member 12 Homo sapiens 96-104
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 109-114 solute carrier family 22 member 12 Homo sapiens 78-83
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 109-114 solute carrier family 22 member 12 Homo sapiens 96-104
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 241-250 solute carrier family 22 member 12 Homo sapiens 78-83
12024214-4 2002 Here we identify the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Uric Acid 241-250 solute carrier family 22 member 12 Homo sapiens 96-104
12024214-5 2002 Moreover, we provide evidence that patients with idiopathic renal hypouricaemia (lack of blood uric acid) have defects in SLC22A12. Uric Acid 95-104 solute carrier family 22 member 12 Homo sapiens 122-130
12024214-6 2002 Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution. Uric Acid 67-72 solute carrier family 22 member 12 Homo sapiens 18-23
11941584-8 2002 Adjusted for BMI, gender, and uric acid (UA), the heritability for serum leptin was 0.18%. Uric Acid 30-39 leptin Homo sapiens 73-79
12076979-7 2002 Protection against peroxynitrite-mediated alpha(1)-AP inactivation is also decreased by ascorbate, Trolox, and GSH, but it is enhanced by uric acid. Uric Acid 138-147 serpin family A member 1 Homo sapiens 42-53
11961098-7 2002 It is also argued that the high concentration of uric acid in the blood of humans and nonhuman primates has developed molecular coevolution with the xanthine oxidoreductase in purine metabolism. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 149-172
12081231-5 2002 From these results, we speculated that octreotide acetate decreases the urinary excretion of uric acid by decreasing the concentration of glucagon and/or urinary excretion of sodium, and increases the plasma concentration of uridine via decreased concentrations of glucagon and insulin. Uric Acid 93-102 insulin Homo sapiens 278-285
11971139-7 2002 AtUPS1 transports uric acid and xanthine, besides allantoin, but not adenine. Uric Acid 18-27 ureide permease 1 Arabidopsis thaliana 0-6
11941584-8 2002 Adjusted for BMI, gender, and uric acid (UA), the heritability for serum leptin was 0.18%. Uric Acid 41-43 leptin Homo sapiens 73-79
12238311-2 2002 The purpose of this study was to assess the relationship between levels of serum uric acid, activity of the renin-angiotensin-aldosterone system and TNF-alpha in heart failure patients with respect to the extent of left ventricular dysfunction. Uric Acid 81-90 tumor necrosis factor Homo sapiens 149-158
12238311-6 2002 Serum uric acid correlated significantly with TNF-alpha concentrations (r = 0.36, P < 0.05) leukocytes (r = 0.38, P = 0.03) and ejection fraction (r = 0.64, P < 0.01). Uric Acid 6-15 tumor necrosis factor Homo sapiens 46-55
11840382-11 2002 In contrast, the percent increase in the Alb-to-Cr ratio in group 3 relative to that in group 2 was the highest, followed by percent increases in the TP-to-Cr, NAG-to-Cr, beta2MG-to-Cr, UA-to-Cr, and UN-to-Cr ratios. Uric Acid 186-188 albumin Homo sapiens 41-44
11922293-4 2002 The peak height of the first peak was due to the concentrations of urate and other reductants in the sample; the immobilized uricase was used to decompose urate, and the hydrogen peroxide produced was decomposed with a luminol-hydrogen peroxide reaction by immobilized peroxidase. Uric Acid 67-72 urate oxidase (pseudogene) Homo sapiens 125-132
11922293-4 2002 The peak height of the first peak was due to the concentrations of urate and other reductants in the sample; the immobilized uricase was used to decompose urate, and the hydrogen peroxide produced was decomposed with a luminol-hydrogen peroxide reaction by immobilized peroxidase. Uric Acid 155-160 urate oxidase (pseudogene) Homo sapiens 125-132
11990393-10 2002 05) with increasing body mass index, fasting insulin, alanine transaminase, uric acid, triglycerides and gammaglutamyltranspeptidase; it decreased with increasing transferrin and quantitative insulin sensitivity check index. Uric Acid 76-85 transferrin Homo sapiens 163-174
11990393-10 2002 05) with increasing body mass index, fasting insulin, alanine transaminase, uric acid, triglycerides and gammaglutamyltranspeptidase; it decreased with increasing transferrin and quantitative insulin sensitivity check index. Uric Acid 76-85 insulin Homo sapiens 192-199
11990393-12 2002 CONCLUSIONS: Fasting insulin and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease. Uric Acid 39-48 insulin Homo sapiens 67-74
11861068-8 2002 Furthermore, we observed that in monosodium urate crystals-stimulated neutrophils, Lyn activity was enhanced in the soluble fraction recovered from the hypertonic fraction, but not from that of the first hypotonic lysis. Uric Acid 33-49 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 83-86
11887176-3 2002 Our study aimed to establish the relationship between uric acid (avoiding the interference of high triglyceride levels), insulin sensitivity, and components of the metabolic syndrome in a group of subjects at high risk of developing DM. Uric Acid 54-63 insulin Homo sapiens 121-128
12044342-6 2002 RESULTS: Women suffering from PIH and preeclampsia showed higher levels of the antioxidants vitamin E and uric acid, and lower levels of vitamin C compared with normal pregnant and nonpregnant women. Uric Acid 106-115 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 30-33
11842287-1 2002 Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or macromolecular organic surfaces (heparin, other mucopolysaccharides, and sulfatides) or on assembly along the surface of cells. Uric Acid 159-164 kininogen 1 Homo sapiens 0-10
11842287-1 2002 Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or macromolecular organic surfaces (heparin, other mucopolysaccharides, and sulfatides) or on assembly along the surface of cells. Uric Acid 159-164 kininogen 1 Homo sapiens 74-105
11993848-11 2002 It is suggested that the major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of oxygen radicals, but rather the production of uric acid which can act as a potent antioxidant. Uric Acid 199-208 xanthine dehydrogenase Rattus norvegicus 43-46
12402621-13 2002 Independent of BMI, higher leptin levels were associated with parameters considered to be CV risk factors (Framingham study), such as serum triglycerides < 150 mg/dL (n = 29) as compared with > 150 mg/dL (44.2 +/- 53.2 ng/mL vs. 80 +/- 58.4 ng/mL, p < 0.05), cholesterol < 250 mg/dL (n = 28) as compared with > 250 mg/dL, (50 +/- 55.6 mg/dL vs. 84.7 +/- 57.7 mg/dL, p < 0.05), uric acid < 7 mg/dL (n = 28) as compared with > 7 mg/dL (47 +/- 53.7 mg/dL vs. 93.1 +/- 56.6 mg/dL, p < 0.05), and the presence or lack of presence of left ventricular hypertrophy [68.8 +/- 60 (n = 30) vs. 29.5 +/- 23.7 (n = 5), p < 0.05]. Uric Acid 395-404 leptin Homo sapiens 27-33
12571440-4 2002 Plasma 5"-nucleotidase activity increased according to increases in uric acid levels and the severity of pre-eclampsia. Uric Acid 68-77 5'-nucleotidase ecto Homo sapiens 7-22
11802744-10 2002 The inhibition was abolished by urate (a scavenger of ONOO(-) and *OH), but not by mannitol (a scavenger of *OH) or superoxide dismutase (a scavenger of O(2)(-)) and appeared to be specific to AII(t), since ONOO(-) only slightly influenced annexin I-mediated liposome aggregation. Uric Acid 32-37 NLR family pyrin domain containing 3 Homo sapiens 193-196
11805243-9 2002 In the CSF, the increase of nitrotyrosine was accompanied by a depletion of the antioxidant ascorbic acid and an increased oxidation of the natural peroxynitrite scavenger uric acid to allantoin. Uric Acid 172-181 colony stimulating factor 2 Homo sapiens 7-10
12168784-1 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. Uric Acid 169-178 xanthine dehydrogenase Homo sapiens 0-23
12168784-1 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. Uric Acid 169-178 xanthine dehydrogenase Homo sapiens 25-47
12238635-1 2002 The serum uric acid level has been said to be an independent predictor of cardiovascular disease death, mainly for women, and to be linked with the metabolic Syndrome X of insulin resistance, obesity, hypertension, and dyslipidemia. Uric Acid 10-19 insulin Homo sapiens 172-179
12238635-3 2002 Therefore, we studied the relationship of uric acid to leptin in 822 Japanese women in a cross-sectional manner. Uric Acid 42-51 leptin Homo sapiens 55-61
12238635-6 2002 Serum leptin concentrations were also elevated in hyperuricemic women after adjusting for BMI or BFM (both p < 0.001), and were weakly correlated with serum uric acid concentrations (r = 0.22, p < 0.0001). Uric Acid 160-169 leptin Homo sapiens 6-12
12238635-9 2002 In the stepwise regression analysis, serum leptin was the significant independent variable for uric acid values. Uric Acid 95-104 leptin Homo sapiens 43-49
12238635-10 2002 These results indicate an independent relationship between leptin and uric acid, further supporting the involvement of leptin in metabolic Syndrome X. Uric Acid 70-79 leptin Homo sapiens 59-65
12238635-10 2002 These results indicate an independent relationship between leptin and uric acid, further supporting the involvement of leptin in metabolic Syndrome X. Uric Acid 70-79 leptin Homo sapiens 119-125
11796116-4 2002 The drug allopurinol is used to treat XDH-catalyzed uric acid build-up occurring in gout or during cancer chemotherapy. Uric Acid 52-61 xanthine dehydrogenase Bos taurus 38-41
11902746-2 2002 The diagnosis of purine nucleoside phosphorylase (PNP) deficiency was suggested by a reduced level of serum uric acid and confirmed by measurement of PNP activity. Uric Acid 108-117 purine nucleoside phosphorylase Homo sapiens 17-48
11902746-2 2002 The diagnosis of purine nucleoside phosphorylase (PNP) deficiency was suggested by a reduced level of serum uric acid and confirmed by measurement of PNP activity. Uric Acid 108-117 purine nucleoside phosphorylase Homo sapiens 50-53
11796116-1 2002 Xanthine dehydrogenase (XDH), a complex molybdo/iron-sulfur/flavoprotein, catalyzes the oxidation of hypoxanthine to xanthine followed by oxidation of xanthine to uric acid with concomitant reduction of NAD+. Uric Acid 163-172 xanthine dehydrogenase Bos taurus 24-27
11728802-2 2001 During EX1 there was a significant accumulation of urate (from 0.16 +/- 0.02 to 0.27 +/- 0.03 micromol/kg d.w.) and allantoin (from 0.39 +/- 0.05 to 0.69 +/- 0.14 micromol/kg d.w.) in the muscle. Uric Acid 51-56 FERM domain containing 6 Homo sapiens 7-10
11853365-7 2001 When subjects with a BMI <40 kg/m2 were considered, plasma leptin was significantly and positively related to anthropometric variables (BMI, percentage body fat and WHR), total cholesterol, LDL-cholesterol, plasma triglycerides, AST, ALT and uric acid; and negatively with HDL-cholesterol. Uric Acid 245-254 leptin Homo sapiens 62-68
11728802-3 2001 An uptake of urate was observed in early recovery from EX1 (0-9 min: 486 +/- 136 micromol; p <.05). Uric Acid 13-18 FERM domain containing 6 Homo sapiens 55-58
11739559-0 2001 Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. Uric Acid 54-70 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 0-3
11844003-11 2001 CRP and IL-6 were important confounders in the relationship between serum uric acid and overall mortality. Uric Acid 74-83 C-reactive protein Homo sapiens 0-3
11844003-11 2001 CRP and IL-6 were important confounders in the relationship between serum uric acid and overall mortality. Uric Acid 74-83 interleukin 6 Homo sapiens 8-12
11739559-0 2001 Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. Uric Acid 54-70 C-X-C motif chemokine ligand 8 Homo sapiens 87-91
11739559-1 2001 Neutrophil-dependent inflammation dependent on monosodium urate (MSU) crystal-induced IL-8 expression occurs in gout. Uric Acid 47-63 C-X-C motif chemokine ligand 8 Homo sapiens 86-90
11739559-1 2001 Neutrophil-dependent inflammation dependent on monosodium urate (MSU) crystal-induced IL-8 expression occurs in gout. Uric Acid 65-68 C-X-C motif chemokine ligand 8 Homo sapiens 86-90
11775566-6 2001 Linear univariate analysis for repeated evaluation showed a positive correlation between leptin and glucose, triglycerides, uric acid, and insulin. Uric Acid 124-133 leptin Homo sapiens 89-95
11774217-7 2001 Logistic regression analysis showed that ACE DD genotype, systolic blood pressure and serum uric acid level were risk factors of DM2 complicated with stroke. Uric Acid 92-101 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 129-132
11590204-2 2001 Involvement of Syk in the responses to monosodium urate crystals. Uric Acid 39-55 spleen associated tyrosine kinase Homo sapiens 15-18
11780763-16 2001 The pattern of uric acid in plasma showed a clear resemblance with that of FRAP and linear regression analysis indicated a very significant relationship (R2 = 0.88, p < 0.0001). Uric Acid 15-24 mechanistic target of rapamycin kinase Homo sapiens 75-79
23604884-3 2001 Xanthine dehydrogenase (XDH) / oxidase (XOD) catalyzes the oxidation of xanthine to uric acid. Uric Acid 84-93 rosy Drosophila melanogaster 0-22
23604884-3 2001 Xanthine dehydrogenase (XDH) / oxidase (XOD) catalyzes the oxidation of xanthine to uric acid. Uric Acid 84-93 rosy Drosophila melanogaster 24-27
23604884-5 2001 XDH codes for uric acid which is a ROS scavenger. Uric Acid 14-23 rosy Drosophila melanogaster 0-3
11590204-4 2001 The tyrosine kinase Syk, which has been largely associated with the phagocytic response by Fc receptors and with spreading mediated by integrins, has been identified as one of the major proteins tyrosine-phosphorylated in human neutrophils upon stimulation by MSU crystals and is known to be mediated in part by the Fc receptor, CD16. Uric Acid 260-263 spleen associated tyrosine kinase Homo sapiens 20-23
11590204-6 2001 The tyrosine-phosphorylation patterns induced by MSU crystals and by the ligation of CD16 were inhibited by piceatannol, which, conversely, only slightly delayed but did not diminish the peak of tyrosine phosphorylation induced by cross-linking CD32 or by the addition of fMet-Leu-Phe. Uric Acid 49-52 Fc gamma receptor IIa Homo sapiens 245-249
11698107-2 2001 Significant Gal9p-mediated transport could be demonstrated for [(14)C]-uric acid and for [(14)C]-PAH(1). Uric Acid 71-80 galectin 9 Homo sapiens 12-17
11586484-0 2001 Serum leptin in formerly small-for-gestational-age children during adolescence: relationship to gender, puberty, body composition, insulin sensitivity, creatinine, and serum uric acid. Uric Acid 174-183 leptin Homo sapiens 6-12
11586484-1 2001 Serum leptin levels reflect body fat mass (FM), and have been described to be related to serum uric acid levels in adult type 2 diabetic and healthy subjects. Uric Acid 95-104 leptin Homo sapiens 6-12
11698107-8 2001 The data of the present study sustain the idea of the involvement of galectin 9 in immune/inflammation processes and in potential-sensitive uric acid translocation. Uric Acid 140-149 galectin 9 Homo sapiens 69-79
11928606-1 2001 Deficiency of hypoxanthine phosphoribosyltransferase (HPRT) has a broad spectrum of clinical manifestations, from the complete enzyme defect, the Lesch-Nyhan syndrome with severe neurological deficiency to the partial defect associated only with uric acid overproduction and its consequences. Uric Acid 246-255 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 54-58
11564645-5 2001 Neither alone nor associated with iron (II) did SIN-1 induce changes in dialysate ascorbic acid or uric acid concentrations. Uric Acid 99-108 MAPK associated protein 1 Homo sapiens 48-53
11708095-3 2001 The immobilized UC was employed to decompose urate, which is one of the major interfering components in serum for a luminol-H2O2 chemiluminescence reaction. Uric Acid 45-50 urate oxidase (pseudogene) Homo sapiens 16-18
11316859-3 2001 The uric acid/creatinine ratio in the urine of uricase-deficient mice ranges from 10 to >30; on a weight basis, these mice excrete 20- to 40-fold more urate than do human subjects. Uric Acid 4-13 urate oxidase Mus musculus 47-54
18968307-0 2001 Direct determination of uric acid in serum by a fluorometric-enzymatic method based on uricase. Uric Acid 24-33 urate oxidase (pseudogene) Homo sapiens 87-94
18968307-1 2001 The present paper describes a method for the fluorometric determination of uric acid in blood serum by its reaction with uricase (UOx). Uric Acid 75-84 urate oxidase (pseudogene) Homo sapiens 121-128
18968307-1 2001 The present paper describes a method for the fluorometric determination of uric acid in blood serum by its reaction with uricase (UOx). Uric Acid 75-84 urate oxidase (pseudogene) Homo sapiens 130-133
18968307-2 2001 The procedure is based on the changes in fluorescence that take place during the enzymatic reaction of UOx with uric acid when the solution is excited at 287 nm and the emission is measured at 330 nm. Uric Acid 112-121 urate oxidase (pseudogene) Homo sapiens 103-106
11469788-7 2001 Although urate, xanthine, and ascorbate can protect superoxide dismutase activity of Cu,Zn SOD from inactivation, they were not effective at protecting Cu,E SOD. Uric Acid 9-14 superoxide dismutase [Cu-Zn] Bos taurus 85-94
11514452-1 2001 Xanthine dehydrogenase (XDH) is a member of the molybdenum hydroxylase family of enzymes catalyzing the oxidation of hypoxanthine and xanthine to uric acid. Uric Acid 146-155 xanthine dehydrogenase Ceratitis capitata 0-22
11514452-1 2001 Xanthine dehydrogenase (XDH) is a member of the molybdenum hydroxylase family of enzymes catalyzing the oxidation of hypoxanthine and xanthine to uric acid. Uric Acid 146-155 xanthine dehydrogenase Ceratitis capitata 24-27
11334804-6 2001 Treatment with the xanthine oxidoreductase inhibitor allopurinol inhibited CSF urate levels earlier than those in blood plasma, supporting the notion that urate was produced within the brain. Uric Acid 79-84 xanthine dehydrogenase Homo sapiens 19-42
11334804-6 2001 Treatment with the xanthine oxidoreductase inhibitor allopurinol inhibited CSF urate levels earlier than those in blood plasma, supporting the notion that urate was produced within the brain. Uric Acid 79-84 colony stimulating factor 2 Homo sapiens 75-78
11334804-6 2001 Treatment with the xanthine oxidoreductase inhibitor allopurinol inhibited CSF urate levels earlier than those in blood plasma, supporting the notion that urate was produced within the brain. Uric Acid 155-160 xanthine dehydrogenase Homo sapiens 19-42
11334804-6 2001 Treatment with the xanthine oxidoreductase inhibitor allopurinol inhibited CSF urate levels earlier than those in blood plasma, supporting the notion that urate was produced within the brain. Uric Acid 155-160 colony stimulating factor 2 Homo sapiens 75-78
11334804-8 2001 Together with data from the literature, the results strongly suggest that xanthine oxidase is not a major cause of oxidative stress in bacterial meningitis and that urate formation due to induction of xanthine oxidoreductase in the brain may in fact represent a protective response. Uric Acid 165-170 xanthine dehydrogenase Homo sapiens 201-224
11316859-1 2001 Uricase-deficient mice develop uric acid nephropathy, with high mortality rates before weaning. Uric Acid 31-40 urate oxidase Mus musculus 0-7
11316859-3 2001 The uric acid/creatinine ratio in the urine of uricase-deficient mice ranges from 10 to >30; on a weight basis, these mice excrete 20- to 40-fold more urate than do human subjects. Uric Acid 154-159 urate oxidase Mus musculus 47-54
11316859-6 2001 Treatment of uricase-deficient mice with PEG-uricase markedly reduced urate levels and, when initiated before weaning, preserved the renal architecture (as evaluated by magnetic resonance micros-copy) and prevented the loss of renal concentrating function. Uric Acid 70-75 urate oxidase Mus musculus 13-20
11316859-6 2001 Treatment of uricase-deficient mice with PEG-uricase markedly reduced urate levels and, when initiated before weaning, preserved the renal architecture (as evaluated by magnetic resonance micros-copy) and prevented the loss of renal concentrating function. Uric Acid 70-75 urate oxidase Mus musculus 45-52
11316859-9 2001 PEG-uricase could provide an effective therapy for uric acid nephropathy and refractory gout in human patients. Uric Acid 51-60 urate oxidase Mus musculus 4-11
11306713-6 2001 hOAT3 also mediated the transport of dehydroepiandrosterone sulfate, ochratoxin A, PGE(2), estradiol glucuronide, taurocholate, glutarate, cAMP and uric acid. Uric Acid 148-157 solute carrier family 22 member 8 Homo sapiens 0-5
11160238-6 2001 To determine whether these changes contributed to the development of the more severe disease that characterizes infection in the IL-4(-/-) animals, we treated infected IL-4(-/-) mice with uric acid, a potent scavenger of ONOO(-). Uric Acid 188-197 interleukin 4 Mus musculus 129-133
11254726-7 2001 Additionally, the amount of immunoprecipitable SAM68 was modulated differentially after stimulation by monosodium urate crystals or by CD32 engagement indicating that the posttranslational modifications and/or protein associations of SAM68 induced by these two agonists differed. Uric Acid 103-119 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 47-52
11254726-7 2001 Additionally, the amount of immunoprecipitable SAM68 was modulated differentially after stimulation by monosodium urate crystals or by CD32 engagement indicating that the posttranslational modifications and/or protein associations of SAM68 induced by these two agonists differed. Uric Acid 103-119 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 234-239
11238274-8 2001 Luminol chemiluminescence, inhibitable by the peroxynitrite scavengers ebselen and uric acid, was markedly increased in apoE(-/-) aortic rings. Uric Acid 83-92 apolipoprotein E Mus musculus 120-124
11264889-0 2001 Uric acid mediates photodynamic inactivation of caprine alpha-2-macroglobulin. Uric Acid 0-9 alpha-2-macroglobulin Homo sapiens 56-77
11264889-2 2001 In this study we show that in the presence of visible light, uric acid disrupted caprine alpha-2-macroglobulin (alpha(2) M) structure and antiproteolytic function in vitro. Uric Acid 61-70 alpha-2-macroglobulin Homo sapiens 89-110
11264889-2 2001 In this study we show that in the presence of visible light, uric acid disrupted caprine alpha-2-macroglobulin (alpha(2) M) structure and antiproteolytic function in vitro. Uric Acid 61-70 alpha-2-macroglobulin Homo sapiens 112-122
11264889-7 2001 Our findings suggest that antiproteolytic activity of caprine alpha(2) M could be compromised via oxidative modification mediated by uric acid. Uric Acid 133-142 alpha-2-macroglobulin Homo sapiens 62-72
11328912-1 2001 BACKGROUND: The angiotensin II (AT II) type I receptor antagonist losartan has been reported to increase urinary uric acid and potassium excretion. Uric Acid 113-122 angiotensinogen Homo sapiens 16-30
11328912-1 2001 BACKGROUND: The angiotensin II (AT II) type I receptor antagonist losartan has been reported to increase urinary uric acid and potassium excretion. Uric Acid 113-122 angiotensinogen Homo sapiens 32-37
11254726-0 2001 Evidence for a role for SAM68 in the responses of human neutrophils to ligation of CD32 and to monosodium urate crystals. Uric Acid 95-111 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 24-29
11254726-5 2001 The results obtained show that SAM68 is present in human neutrophils and that it is tyrosine phosphorylated in response to stimulation by monosodium urate crystals or by ligation of CD32. Uric Acid 138-154 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 31-36
11283348-3 2001 When Lpe1 was expressed in a purine transport-deficient A. nidulans strain, the capacity for uric acid and xanthine transport was acquired. Uric Acid 93-102 nucleobase-ascorbate transporter LPE1 Zea mays 5-9
11283348-6 2001 Kinetic analysis established that LPE1 is a high-affinity (K(m) = 30 +/- 2.5 microM), high-capacity transporter specific for the oxidized purines xanthine and uric acid. Uric Acid 159-168 nucleobase-ascorbate transporter LPE1 Zea mays 34-38
11241585-2 2001 The deficiency of hypoxanthine-guanine phosphoribosyl transferase (HGPRT) in LNS leads to increased hypoxanthine and uric acid production. Uric Acid 117-126 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 18-65
11241585-2 2001 The deficiency of hypoxanthine-guanine phosphoribosyl transferase (HGPRT) in LNS leads to increased hypoxanthine and uric acid production. Uric Acid 117-126 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 67-72
11238274-9 2001 In vessels from apoE(-/-) mice, uric acid improved endothelium-dependent relaxation while having no effect in vessels from control mice. Uric Acid 32-41 apolipoprotein E Mus musculus 16-20
11296961-0 2001 Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. Uric Acid 49-58 insulin Homo sapiens 78-85
11296961-1 2001 OBJECTIVE: To explore gender differences in the relationship of serum uric acid levels with fasting serum insulin and fasting plasma glucose concentrations among an adult Chinese nondiabetic population in Kinmen, Taiwan. Uric Acid 70-79 insulin Homo sapiens 106-113
11296961-8 2001 Elevated levels of uric acid should alert physicians to the possibility of insulin resistance. Uric Acid 19-28 insulin Homo sapiens 75-82
11296961-9 2001 The serum uric acid level was associated with insulin resistance and plasma glucose levels more strongly in females than in males in our study population. Uric Acid 10-19 insulin Homo sapiens 46-53
11160238-6 2001 To determine whether these changes contributed to the development of the more severe disease that characterizes infection in the IL-4(-/-) animals, we treated infected IL-4(-/-) mice with uric acid, a potent scavenger of ONOO(-). Uric Acid 188-197 interleukin 4 Mus musculus 168-172
11092937-1 2000 Xanthine dehydrogenase catalyzes the oxidation of hypoxanthine to xanthine and the further oxidation of xanthine to uric acid. Uric Acid 116-125 xanthine dehydrogenase Bos taurus 0-22
11167927-8 2001 E3+GHBP appears to have a considerably stronger correlation to indicators (BMI, fat mass, waist circumference) and metabolic risk factors (fasting insulin, uric acid, triglycerides, apolipoprotein B, diastolic blood pressure) of adiposity than E3-GHBP, indicating differences in their functional significance. Uric Acid 156-165 growth hormone receptor Homo sapiens 3-7
11133262-2 2001 Uric acid, an effective scavenger of peroxynitrite, is a purine metabolite present at high levels in the serum of hominoids relative to lower-order animals due to the functional deletion of urate oxidase. Uric Acid 0-9 urate oxidase Mus musculus 190-203
11128362-3 2000 RESULTS: There was a statistically significant positive crude correlation between C-reactive protein and TC (R = 0.19), TG (R = 0.29), BMI (R = 0.32), glucose (R = 0.11), and uric acid (R = 0.14) (all P < 0.0001). Uric Acid 175-184 C-reactive protein Homo sapiens 82-100
11235645-10 2000 Following reoxygenation an increase in uric acid contents with a concomitant CAT tissue consumption appear evident. Uric Acid 39-48 catalase Homo sapiens 77-80
11086092-3 2000 The inclusion of physiological levels of UA in culture effectively inhibited ONOO(-)-mediated oxidation as well as tyrosine nitration, which has been associated with damage in EAE and multiple sclerosis, but had no inhibitory effect on the T cell-proliferative response to myelin basic protein (MBP) or on APC function. Uric Acid 41-43 myelin basic protein Mus musculus 273-293
11086092-3 2000 The inclusion of physiological levels of UA in culture effectively inhibited ONOO(-)-mediated oxidation as well as tyrosine nitration, which has been associated with damage in EAE and multiple sclerosis, but had no inhibitory effect on the T cell-proliferative response to myelin basic protein (MBP) or on APC function. Uric Acid 41-43 myelin basic protein Mus musculus 295-298
11086092-6 2000 However, in UA-treated animals, the blood-CNS barrier breakdown normally associated with EAE did not occur, and inducible NO synthase-positive cells most often failed to reach CNS tissue. Uric Acid 12-14 nitric oxide synthase 2, inducible Mus musculus 112-133
11124337-3 2000 Catalase competes with 324 U/L horseradish peroxidase (type XII) and Trinder reagent for hydrogen peroxide produced by 46 U/L uricase action on urate. Uric Acid 144-149 catalase Homo sapiens 0-8
10998568-0 2000 Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. Uric Acid 173-182 myelin basic protein Mus musculus 14-34
10998568-4 2000 In this study we have examined the effect of UA therapy on the dynamics of the appearance of iNOS-positive cells in central nervous system (CNS) tissue of mice subjected to the stimuli that cause EAE. Uric Acid 45-47 nitric oxide synthase 2, inducible Mus musculus 93-97
11036845-0 2000 The inhibition of spontaneous and tumor necrosis factor-alpha induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate and monosodium urate monohydrate. Uric Acid 142-170 tumor necrosis factor Homo sapiens 34-61
11036845-3 2000 We investigated the effect of short term incubation of opsonized crystals of monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) on both spontaneous and tumor necrosis factor-alpha (TNF-alpha) induced neutrophil apoptosis. Uric Acid 77-105 tumor necrosis factor Homo sapiens 179-206
11036845-3 2000 We investigated the effect of short term incubation of opsonized crystals of monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) on both spontaneous and tumor necrosis factor-alpha (TNF-alpha) induced neutrophil apoptosis. Uric Acid 77-105 tumor necrosis factor Homo sapiens 208-217
11036845-3 2000 We investigated the effect of short term incubation of opsonized crystals of monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) on both spontaneous and tumor necrosis factor-alpha (TNF-alpha) induced neutrophil apoptosis. Uric Acid 107-111 tumor necrosis factor Homo sapiens 179-206
10943868-10 2000 Culture supernatants from mature macrophages did not stimulate endothelial cell activation, in contrast to MSU-treated cells at an earlier stage of differentiation, which stimulated intercellular adhesion molecule 1 expression on sEND endothelioma cells through the release of TNFalpha (inhibited 80.6% by anti-TNFa). Uric Acid 107-110 intercellular adhesion molecule 1 Mus musculus 182-215
11079811-5 2000 This 8-year longitudinal study demonstrates that dyslipidemia, high blood pressure, and uric acid are associated with insulin resistance, whereas high systolic blood pressure and VLDL cholesterol are associated with impaired first-phase insulin secretion. Uric Acid 88-97 insulin Homo sapiens 118-125
10903352-0 2000 Effect of tea and coffee consumption on serum uric acid levels by liquid-chromatographic and uricase methods. Uric Acid 46-55 urate oxidase (pseudogene) Homo sapiens 93-100
11126199-0 2000 Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Uric Acid 76-85 macrophage migration inhibitory factor Rattus norvegicus 15-53
11126199-0 2000 Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Uric Acid 76-85 macrophage migration inhibitory factor Rattus norvegicus 55-58
11126199-2 2000 We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH). Uric Acid 21-30 macrophage migration inhibitory factor Rattus norvegicus 116-154
11126199-2 2000 We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH). Uric Acid 21-30 macrophage migration inhibitory factor Rattus norvegicus 156-159
11126199-3 2000 MATERIALS AND METHODS: A model of acute uric acid nephropathy was induced in rats by the administration of oxonic acid (an inhibitor of uricase), together with uric acid supplements. Uric Acid 40-49 urate oxidase Rattus norvegicus 136-143
11126199-8 2000 Interestingly, cytoplasmic staining for MIF protein in the uric acid (UA) crystal-associated granulomatous lesions was reduced, indicating a rapid MIF secretion by damaged tubules and macrophages secondary to uric acid crystal stimulation. Uric Acid 59-68 macrophage migration inhibitory factor Rattus norvegicus 40-43
11126199-8 2000 Interestingly, cytoplasmic staining for MIF protein in the uric acid (UA) crystal-associated granulomatous lesions was reduced, indicating a rapid MIF secretion by damaged tubules and macrophages secondary to uric acid crystal stimulation. Uric Acid 70-72 macrophage migration inhibitory factor Rattus norvegicus 40-43
11126199-8 2000 Interestingly, cytoplasmic staining for MIF protein in the uric acid (UA) crystal-associated granulomatous lesions was reduced, indicating a rapid MIF secretion by damaged tubules and macrophages secondary to uric acid crystal stimulation. Uric Acid 209-218 macrophage migration inhibitory factor Rattus norvegicus 40-43
11005854-1 2000 Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Uric Acid 90-95 xanthine dehydrogenase Bos taurus 139-161
11005854-1 2000 Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Uric Acid 90-95 xanthine dehydrogenase Bos taurus 163-166
10943868-10 2000 Culture supernatants from mature macrophages did not stimulate endothelial cell activation, in contrast to MSU-treated cells at an earlier stage of differentiation, which stimulated intercellular adhesion molecule 1 expression on sEND endothelioma cells through the release of TNFalpha (inhibited 80.6% by anti-TNFa). Uric Acid 107-110 tumor necrosis factor Mus musculus 277-285
10943868-10 2000 Culture supernatants from mature macrophages did not stimulate endothelial cell activation, in contrast to MSU-treated cells at an earlier stage of differentiation, which stimulated intercellular adhesion molecule 1 expression on sEND endothelioma cells through the release of TNFalpha (inhibited 80.6% by anti-TNFa). Uric Acid 107-110 tumor necrosis factor Mus musculus 277-281
10827005-6 2000 The reductions in ALPase activity and osteocalcin gene expression were also restored by urate. Uric Acid 88-93 bone gamma-carboxyglutamate protein Homo sapiens 38-49
10913581-6 2000 Urate (ONOO(-) scavenger) did not influence the toxicity of either S-nitroso-N-acetylpenicillamine or sodium nitroprusside, but protected from SIN-1 (3-morpholinosydnonimine, ONOO(-) donor). Uric Acid 0-5 MAPK associated protein 1 Homo sapiens 143-148
10817569-0 2000 Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Uric Acid 270-298 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 141-160
10836987-2 2000 UA crystals bind rapidly to monolayer cultures of monkey kidney epithelial cells (BSC-1 line), used to model the surface of the nephron, in a concentration-dependent manner. Uric Acid 0-2 solute carrier family 12 member 1 Homo sapiens 82-87
10836987-5 2000 However, removal of anionic cell surface molecules with neuraminidase, heparitinase I, or chondroitinase ABC each increased UA crystal binding, and sialic acid-binding lectins had no effect. Uric Acid 124-126 neuraminidase 1 Homo sapiens 56-69
10878654-15 2000 CONCLUSION: When pre- and post-Ramadan lipid and lipoprotein profiles were compared in stable hyperlipidaemic subjects attending a Lipid Clinic in Kuwait, the most consistent changes post-Ramadan were increased levels of apo A-1 and apo A-1/apo B and apo A-1/HDL ratios and reduced uric acid levels. Uric Acid 282-291 apolipoprotein A1 Homo sapiens 221-228
10877394-0 2000 Estimation of the flow of microbial nitrogen to the duodenum using milk uric acid or allantoin. Uric Acid 72-81 Weaning weight-maternal milk Bos taurus 67-71
10877394-3 2000 The coefficient of determination for individual experiments for the relationship between microbial nitrogen flow and allantoin or uric acid excretion in milk ranged from -0.01 to 0.77 and -0.06 to 0.22 respectively. Uric Acid 130-139 Weaning weight-maternal milk Bos taurus 153-157
10877394-4 2000 Across all experiments, the coefficients of determination between microbial nitrogen flow and allantoin or uric acid excretion in milk were r2 = 0.09 and 0.01 respectively. Uric Acid 107-116 Weaning weight-maternal milk Bos taurus 130-134
10817569-0 2000 Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Uric Acid 270-298 C-X-C motif chemokine ligand 8 Homo sapiens 231-244
10836367-12 2000 CONCLUSIONS: Conversion from azathioprine to MMF with consecutive reduction of CsA in heart transplant recipients with CsA-impaired renal function improves renal function as evidenced by lower serum creatinine, urea nitrogen, uric acid, and higher creatinine clearance. Uric Acid 226-235 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 79-82
10707571-4 2000 It is of interest to examine the effects of insulin sensitizer which was developed recently on serum urate concentration because it may provide a new idea as to the mechanism of the association between IR, hyperuricemia and vascular disorders. Uric Acid 101-106 insulin Homo sapiens 44-51
10733936-7 2000 Human NPT1 also accepted uric acid, benzylpenicillin, faropenem, and estradiol-17beta-glucuronide as substrates. Uric Acid 25-34 solute carrier family 17 member 1 Homo sapiens 6-10
10727684-3 2000 In the continuous ACTH loading test, the plasma concentration of uric acid and oxypurines (hypoxanthine and xanthine) decreased, and the urinary excretion and fractional clearance of them increased as well as the plasma concentrations and urinary excretion of cortisol. Uric Acid 65-74 proopiomelanocortin Homo sapiens 18-22
10944859-0 2000 The C677T mutation in the methylene tetrahydrofolate reductase gene increases serum uric acid in elderly men. Uric Acid 84-93 methylenetetrahydrofolate reductase Homo sapiens 26-62
10625614-5 2000 Ad-mG6Pase infusion also greatly improved growth of G6Pase(-/-) mice and normalized plasma glucose, cholesterol, triglyceride, and uric acid profiles. Uric Acid 131-140 glucose-6-phosphatase, catalytic Mus musculus 3-10
10625614-5 2000 Ad-mG6Pase infusion also greatly improved growth of G6Pase(-/-) mice and normalized plasma glucose, cholesterol, triglyceride, and uric acid profiles. Uric Acid 131-140 glucose-6-phosphatase, catalytic Mus musculus 4-10
11790327-3 2000 The paradox was explained in part, by the presence in serum of purine nucleoside phosphorylase and adenosine deaminase, that, together with xanthine oxidase, catabolized adenosine, inosine, hypoxanthine, and xanthine to uric acid yielding trypanocidal H(2)O(2). Uric Acid 220-229 adenosine deaminase Homo sapiens 99-118
11416233-2 2000 RESULTS: Multiple regression analysis indicated that among the various parameters examined, the level of leptin was positively associated with the body mass index and the levels of insulin, total cholesterol and uric acid, and was inversely associated with physical activity and the level of creatinine. Uric Acid 212-221 leptin Homo sapiens 105-111
10685834-0 2000 Interleukin 6 reduces serum urate concentrations. Uric Acid 28-33 interleukin 6 Homo sapiens 0-13
10944859-3 2000 The relationship between the MTHFR mutation and uric acid metabolism remains unclear, however. Uric Acid 48-57 methylenetetrahydrofolate reductase Homo sapiens 29-34
10944859-7 2000 These findings suggest that the C677T MTHFR mutation contributed to higher uric acid levels in subjects enrolled in this study. Uric Acid 75-84 methylenetetrahydrofolate reductase Homo sapiens 38-43
10604966-1 2000 Xanthine oxidoreductase (XOR) is a mammalian enzyme that possesses a series of redox centers, which use either NAD(+) or molecular oxygen for oxidation of the purines xanthine and hypoxanthine to uric acid. Uric Acid 196-205 xanthine dehydrogenase Homo sapiens 0-23
10604966-1 2000 Xanthine oxidoreductase (XOR) is a mammalian enzyme that possesses a series of redox centers, which use either NAD(+) or molecular oxygen for oxidation of the purines xanthine and hypoxanthine to uric acid. Uric Acid 196-205 xanthine dehydrogenase Homo sapiens 25-28
11334371-0 2000 Serum leptin correlates with serum uric acid but not serum testosterone in non-obese male adolescents. Uric Acid 35-44 leptin Homo sapiens 6-12
11334371-7 2000 Stepwise multiple regression analysis showed that UA independently and significantly influenced serum leptin levels in both the test and control groups. Uric Acid 50-52 leptin Homo sapiens 102-108
10601147-5 1999 Plasma uric acid concentration was higher (P < 0.05) in B8 compared with B1 and B4 after 45, 60, and 120 min of recovery. Uric Acid 7-16 membrane spanning 4-domains A1 Homo sapiens 76-94
10629427-5 1999 Urate, a scavenger of peroxynitrite, attenuated the VEGF-induced oxidation of DCHF. Uric Acid 0-5 vascular endothelial growth factor A Bos taurus 52-56
10703880-5 1999 RESULTS: Positive FHx of HTN was significantly associated with increasing urinary excretion of uric acid (P = 0.03) but not with the excretion of the other substances. Uric Acid 95-104 forkhead box J2 Homo sapiens 18-21
10502907-7 1999 Factor VIIIc, factor VIIc, and fibrinogen, ordered by the strength of the correlation, were positively and significantly correlated with glucose, uric acid, and blood pressure levels. Uric Acid 146-155 fibrinogen beta chain Homo sapiens 31-41
10517148-3 1999 The prepared electrode exhibited such fast steady amperometric responses to uric acid as to allow its determination within 20 s after injecting uric acid, indicating that UOx-catalyzed electrochemical oxidation of uric acid was accomplished with assistance of electron mediation by MMP between UOx and the Au substrate. Uric Acid 76-85 urate oxidase (pseudogene) Homo sapiens 171-174
10517148-3 1999 The prepared electrode exhibited such fast steady amperometric responses to uric acid as to allow its determination within 20 s after injecting uric acid, indicating that UOx-catalyzed electrochemical oxidation of uric acid was accomplished with assistance of electron mediation by MMP between UOx and the Au substrate. Uric Acid 144-153 urate oxidase (pseudogene) Homo sapiens 171-174
10517148-3 1999 The prepared electrode exhibited such fast steady amperometric responses to uric acid as to allow its determination within 20 s after injecting uric acid, indicating that UOx-catalyzed electrochemical oxidation of uric acid was accomplished with assistance of electron mediation by MMP between UOx and the Au substrate. Uric Acid 144-153 urate oxidase (pseudogene) Homo sapiens 171-174
10583426-10 1999 In the kidney, insulin spares sodium and uric acid from excretion; in chronic hyperinsulinaemic states, these effects may contribute to high blood pressure and hyperuricaemia. Uric Acid 41-50 insulin Homo sapiens 15-22
10506947-15 1999 Xanthine oxidase has been suggested to be involved in the pathogenesis of post-ischemic reperfusion tissue injury through the generation of reactive oxygen species, while the extensive tissue localization of xanthine dehydrogenase/oxidase suggests several other roles for this enzyme, including a protective barrier against bacterial infection by producing either superoxide radicals or uric acid. Uric Acid 387-396 xanthine dehydrogenase Homo sapiens 208-238
10638162-9 1999 Uric acid, the marker of glomerular and tubular damage, was higher in the pre-eclampsia group (0.27 mmol/L) than in the control (0.20 mmol/L), and PIH groups (0.24 mmol/L), (p < 0.05). Uric Acid 0-9 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 147-150
10522560-9 1999 Serum uric acid was significantly correlated with body weight, BP, glucose, fibrinogen, urea, creatinin and total cholesterol. Uric Acid 6-15 fibrinogen beta chain Homo sapiens 76-86
11205821-0 1999 Estimation of plasma uric acid in pregnancy induced hypertension (PIH). Uric Acid 21-30 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 66-69
11205821-3 1999 Results in the third trimester of pregnancy confirmed that the plasma uric acid was able to differentiate between normal pregnancy and those with PIH at P < 0.002. Uric Acid 70-79 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 146-149
10452962-6 1999 H(2)O(2) addition to i-NOS macrophages also caused cell death which was, in part, prevented by DETC or urate. Uric Acid 103-108 nitric oxide synthase 2 Homo sapiens 21-26
10526565-2 1999 RELATIVE PROGNOSTIC VALUES: Neuron specific enolase (NSE) would have a pretherapeutic prognostic value better than LDH (lacto-dehydrogenase) and perhaps better than serum sodium, biocarbonates, and uric acid. Uric Acid 198-207 enolase 2 Homo sapiens 28-51
10526565-2 1999 RELATIVE PROGNOSTIC VALUES: Neuron specific enolase (NSE) would have a pretherapeutic prognostic value better than LDH (lacto-dehydrogenase) and perhaps better than serum sodium, biocarbonates, and uric acid. Uric Acid 198-207 enolase 2 Homo sapiens 53-56
10419058-6 1999 Selective insulin resistance and hyperinsulinism estimulates the tubular sodium-hydrogen exchanger and facilitates the active reabsorption of urate. Uric Acid 142-147 insulin Homo sapiens 10-17
10910618-6 1999 Regression coefficients (bZX) for total cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin were significantly different (p < 0.05-0.01), showing the result of genetic control, because their heritabilities were very high at 0.75-1.0, 0.77-1.0, 0.96-1.0, and 0.48-0.82, respectively. Uric Acid 90-99 BZX Homo sapiens 25-28
10428045-4 1999 Pretreatment of cultures with 17beta-estradiol, vitamin E, and uric acid largely prevented Par-4 induction and cell death following TFW, demonstrating necessary roles for oxidative stress and membrane lipid peroxidation in TFW-induced neuronal apoptosis. Uric Acid 63-72 pro-apoptotic WT1 regulator Rattus norvegicus 91-96
10451080-6 1999 The serum uric acid concentration among male HPRT(Tsou) carriers in the patient"s family was significantly higher than among those who had at least one HPRT gene that did not have HPRT(Tsou). Uric Acid 10-19 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 45-49
10451080-6 1999 The serum uric acid concentration among male HPRT(Tsou) carriers in the patient"s family was significantly higher than among those who had at least one HPRT gene that did not have HPRT(Tsou). Uric Acid 10-19 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 152-156
10451080-6 1999 The serum uric acid concentration among male HPRT(Tsou) carriers in the patient"s family was significantly higher than among those who had at least one HPRT gene that did not have HPRT(Tsou). Uric Acid 10-19 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 152-156
10444366-3 1999 The injurious effect of SIN-1 was prevented by oxyhemoglobin or by uric acid but not by superoxide dismutase. Uric Acid 67-76 MAPK associated protein 1 Homo sapiens 24-29
10361492-4 1999 The resulting electrode (poly-MPD/UOx/Au) exhibited amperometric responses to uric acid with very fast response of approximately 30 s, allowing reagentless amperometric determination in a concentration range covering that in the blood of a healthy human being. Uric Acid 78-87 mevalonate diphosphate decarboxylase Homo sapiens 30-33
10364675-1 1999 Familial benign polycythemia (FBP) (OMIM 263400) is a rare autosomal recessive condition characterized by erythrocytosis, normal leukocyte and platelet counts, normal uric acid level, and usually increased erythropoietin production. Uric Acid 167-176 ECB2 Homo sapiens 30-33
10369213-5 1999 Nitric oxide synthase inhibitors and the peroxynitrite scavenger uric acid blocked the apoptosis-enhancing action of PS-1 mutations. Uric Acid 65-74 presenilin 1 Rattus norvegicus 117-121
10381138-0 1999 Serum leptin is associated with serum uric acid concentrations in humans. Uric Acid 38-47 leptin Homo sapiens 6-12
10381138-3 1999 Multiple regression analyses showed that the estimates of total body obesity (BMI, percent body fat, and total FM), sex, and serum uric acid concentration are independently associated with the serum leptin concentration. Uric Acid 131-140 leptin Homo sapiens 199-205
10381138-4 1999 The finding of a positive correlation between serum leptin and uric acid levels suggests that leptin could be a pathogenic factor responsible for hyperuricemia in obesity. Uric Acid 63-72 leptin Homo sapiens 52-58
10381138-4 1999 The finding of a positive correlation between serum leptin and uric acid levels suggests that leptin could be a pathogenic factor responsible for hyperuricemia in obesity. Uric Acid 63-72 leptin Homo sapiens 94-100
10361492-0 1999 Uricase-catalyzed oxidation of uric acid using an artificial electron acceptor and fabrication of amperometric uric acid sensors with use of a redox ladder polymer. Uric Acid 31-40 urate oxidase (pseudogene) Homo sapiens 0-7
10361492-0 1999 Uricase-catalyzed oxidation of uric acid using an artificial electron acceptor and fabrication of amperometric uric acid sensors with use of a redox ladder polymer. Uric Acid 111-120 urate oxidase (pseudogene) Homo sapiens 0-7
10361492-1 1999 Electrochemical oxidation of uric acid catalyzed by uricase (uric acid oxidase, UOx; EC 1.7.3.3) was studied using several redox compounds including 5-methylphenazinium (MP) and 1-methoxy-5-methylphenazinium (MMP) as electron acceptors for UOx, which does not contain any redox cofactor. Uric Acid 29-38 urate oxidase (pseudogene) Homo sapiens 52-59
10361492-1 1999 Electrochemical oxidation of uric acid catalyzed by uricase (uric acid oxidase, UOx; EC 1.7.3.3) was studied using several redox compounds including 5-methylphenazinium (MP) and 1-methoxy-5-methylphenazinium (MMP) as electron acceptors for UOx, which does not contain any redox cofactor. Uric Acid 29-38 urate oxidase (pseudogene) Homo sapiens 80-83
10361492-1 1999 Electrochemical oxidation of uric acid catalyzed by uricase (uric acid oxidase, UOx; EC 1.7.3.3) was studied using several redox compounds including 5-methylphenazinium (MP) and 1-methoxy-5-methylphenazinium (MMP) as electron acceptors for UOx, which does not contain any redox cofactor. Uric Acid 29-38 urate oxidase (pseudogene) Homo sapiens 240-243
10361492-2 1999 It was found that MP and MMP were useful to mediate electrons from UOx to an electrode in the enzymatic oxidation of uric acid. Uric Acid 117-126 urate oxidase (pseudogene) Homo sapiens 67-70
10354276-7 1999 The effect of SIN-1 (500 microM) on LLC-PK1 cell adhesion was not associated with either cell death or alteration of matrix protein and was attenuated by either the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, the superoxide scavenger superoxide dismutase, or the ONOO- scavenger uric acid in a dose-dependent manner. Uric Acid 315-324 MAPK associated protein 1 Homo sapiens 14-19
10361492-4 1999 The resulting electrode (poly-MPD/UOx/Au) exhibited amperometric responses to uric acid with very fast response of approximately 30 s, allowing reagentless amperometric determination in a concentration range covering that in the blood of a healthy human being. Uric Acid 78-87 urate oxidase (pseudogene) Homo sapiens 34-37
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 163-172 mevalonate diphosphate decarboxylase Homo sapiens 108-111
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 163-172 urate oxidase (pseudogene) Homo sapiens 112-115
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 163-172 urate oxidase (pseudogene) Homo sapiens 311-314
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 204-213 mevalonate diphosphate decarboxylase Homo sapiens 108-111
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 204-213 urate oxidase (pseudogene) Homo sapiens 112-115
10361492-5 1999 Kinetic parameters of the apparent Michaelis constant and the maximum current response obtained at the poly-MPD/UOx/Au suggested that electrochemical oxidation of uric acid was controlled by diffusion of uric acid into the enzyme film and that the redox polymer worked well in mediating between active sites of UOx molecules and the electrode substrate. Uric Acid 204-213 urate oxidase (pseudogene) Homo sapiens 311-314
10211753-8 1999 Serum levels of uric acid (UA) and lactic dehydrogenase (LDH) increased under G-CSF, and platelets decreased after G-CSF discontinuation. Uric Acid 16-25 colony stimulating factor 3 Homo sapiens 78-83
10392568-0 1999 Discrete analysis of serum uric acid with immobilized uricase and peroxidase. Uric Acid 27-36 urate oxidase (pseudogene) Homo sapiens 54-61
10392568-2 1999 A discrete method has been developed to determine uric acid in serum using immobilized uricase and peroxidase. Uric Acid 50-59 urate oxidase (pseudogene) Homo sapiens 87-94
10392568-3 1999 The method is based on generation of H2O2 from serum uric acid by immobilized uricase and its measurement by a colour reaction catalyzed by immobilized peroxidase. Uric Acid 53-62 urate oxidase (pseudogene) Homo sapiens 78-85
10361434-2 1999 In animals with chronic renal failure, plasma levels of angiotensin II and specific 125I-angiotensin II binding sites increase and result in enhanced excretions of K+, Cl- and urate from distal colon, in an AT1-receptor sensitive manner. Uric Acid 176-181 angiotensinogen Homo sapiens 56-103
10211753-8 1999 Serum levels of uric acid (UA) and lactic dehydrogenase (LDH) increased under G-CSF, and platelets decreased after G-CSF discontinuation. Uric Acid 27-29 colony stimulating factor 3 Homo sapiens 78-83
10037473-5 1999 The peroxynitrite-scavenging antioxidant uric acid and the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone protected hippocampal neurons expressing mutant PS1 against cell death induced by amyloid beta-peptide. Uric Acid 41-50 presenilin 1 Homo sapiens 175-178
10189006-4 1999 Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Uric Acid 139-148 insulin Homo sapiens 0-7
10075379-6 1999 In normotensive subjects, serum uric acid, which is known to be related to sodium handling at renal tubules of microalbuminuria-positive subjects, was significantly higher than those of microalbuminuria negative subjects as well as triglycerides and area of insulin, without the differences of the levels of blood pressure and BMI. Uric Acid 32-41 insulin Homo sapiens 258-265
9917333-10 1999 Antioxidants (GSH, ascorbate, Trolox C, vitamin E, and urate) react with the myoglobin-derived peroxyl radical; in some cases antioxidant-derived radicals are detected. Uric Acid 55-60 myoglobin Equus caballus 77-86
9927176-1 1999 Xanthine dehydrogenase (XDH) is a molybdoenzyme which catalyses oxidation of xanthine and hypoxanthine to uric acid. Uric Acid 106-115 xanthine dehydrogenase 1 Bombyx mori 0-22
9927176-1 1999 Xanthine dehydrogenase (XDH) is a molybdoenzyme which catalyses oxidation of xanthine and hypoxanthine to uric acid. Uric Acid 106-115 xanthine dehydrogenase 1 Bombyx mori 24-27
9882614-2 1999 Although they are involved in fMet-Leu-Phe (fMLP)-mediated PLD activation, their role in monosodium urate (MSU)-stimulated PLD1 activity in human neutrophils is not clear. Uric Acid 89-105 phospholipase D1 Homo sapiens 123-127
9882614-2 1999 Although they are involved in fMet-Leu-Phe (fMLP)-mediated PLD activation, their role in monosodium urate (MSU)-stimulated PLD1 activity in human neutrophils is not clear. Uric Acid 107-110 phospholipase D1 Homo sapiens 123-127
9887087-6 1999 hOAT1-mediated PAH uptake was inhibited by bulky inorganic anions, various xenobiotics, and endogenous substances, including benzylpenicillin, furosemide, indomethacin, probenecid, phenol red, urate, and alpha-ketoglutarate. Uric Acid 193-198 solute carrier family 22 member 6 Homo sapiens 0-5
9822451-4 1998 Xanthine oxidoreductase (XOR) oxidizes ATP metabolites hypoxanthine and xanthine to urate. Uric Acid 84-89 xanthine dehydrogenase Rattus norvegicus 0-23
10888479-1 1999 Xanthine oxidoreductase (XD: xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes oxidation of hypoxathine to xanthine, subsequently producing uric acid. Uric Acid 168-177 xanthine dehydrogenase Homo sapiens 0-23
10888479-1 1999 Xanthine oxidoreductase (XD: xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes oxidation of hypoxathine to xanthine, subsequently producing uric acid. Uric Acid 168-177 xanthine dehydrogenase Homo sapiens 29-51
9886724-8 1998 In patients with chronic heart failure, serum uric acid concentrations correlated with circulating levels of sTNFR1 (r=0.74), interleukin-6 (r=0.66), sTNFR2 (r=0.63), TNFa (r=0.60) (all P<0.001), and ICAM-1 (r=0.41, P<0.01). Uric Acid 46-55 interleukin 6 Homo sapiens 126-139
9886724-8 1998 In patients with chronic heart failure, serum uric acid concentrations correlated with circulating levels of sTNFR1 (r=0.74), interleukin-6 (r=0.66), sTNFR2 (r=0.63), TNFa (r=0.60) (all P<0.001), and ICAM-1 (r=0.41, P<0.01). Uric Acid 46-55 tumor necrosis factor Homo sapiens 167-171
9886724-8 1998 In patients with chronic heart failure, serum uric acid concentrations correlated with circulating levels of sTNFR1 (r=0.74), interleukin-6 (r=0.66), sTNFR2 (r=0.63), TNFa (r=0.60) (all P<0.001), and ICAM-1 (r=0.41, P<0.01). Uric Acid 46-55 intercellular adhesion molecule 1 Homo sapiens 203-209
9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 intercellular adhesion molecule 1 Homo sapiens 87-93
9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 interleukin 6 Homo sapiens 95-108
9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 tumor necrosis factor Homo sapiens 110-113
9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 insulin Homo sapiens 227-234
9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 insulin Homo sapiens 252-259
10394004-10 1999 Fluids containing haptoglobin >53% or associated with cumulus-oocyte complexes of bad quality displayed levels of uric acid about 20-fold higher than in plasma. Uric Acid 117-126 haptoglobin Bubalus bubalis 18-29
10394004-11 1999 The results suggest that a high penetration of haptoglobin in the follicle and cumulus-oocyte degradation is associated with alterations of the level of the major antioxidants, particularly with enhancement of the uric acid concentration. Uric Acid 214-223 haptoglobin Bubalus bubalis 47-58
10622277-3 1999 XOR is an enzyme involved in purine metabolism, converting ATP metabolites hypoxanthine and xanthine to uric acid. Uric Acid 104-113 xanthine dehydrogenase Rattus norvegicus 0-3
9878167-8 1998 An inhibitor of nitric oxide synthase, and the peroxynitrite scavenger uric acid, protected neurons against Tat-induced apoptosis, indicating requirements for nitric oxide production and peroxynitrite formation in the cell death process. Uric Acid 71-80 tyrosine aminotransferase Homo sapiens 108-111
9823550-5 1998 100 mumol/l uric acid, which is still below the human serum level of 300 mumol/l, reduced consumption of alpha-tocopherol and beta-carotene by about 50% and largely suppressed PUFA oxidation for up to 4 h. A more lipophilic series of methyl analogues of uric acid exhibited less activity. Uric Acid 12-21 pumilio RNA binding family member 3 Homo sapiens 176-180
9822451-4 1998 Xanthine oxidoreductase (XOR) oxidizes ATP metabolites hypoxanthine and xanthine to urate. Uric Acid 84-89 xanthine dehydrogenase Rattus norvegicus 25-28
9773783-10 1998 Uric acid, xanthine, and hypoxanthine was found to suppress basal as well as calcitriol-induced CD14 expression of monocytes in a dose-dependent manner. Uric Acid 0-9 CD14 molecule Homo sapiens 96-100
18967358-3 1998 The concentration range of linear response and detection limit were 0.1-10 and 0.05 mM, the interference of ascorbic acid and uric acid were eliminated by the presence of SAMs and the enzyme electrodes were stable over 3 weeks. Uric Acid 126-135 methionine adenosyltransferase 1A Homo sapiens 171-175
10410574-22 1998 S.ICAM-1, s.VCAM-1 and s.E-selectin serum levels showed a correlation with plasma uric acid concentration and arterial pressure, whereas the other two molecules with the plasma level of triglycerides. Uric Acid 82-91 selectin E Homo sapiens 25-35
9747747-19 1998 The serum level of urate decreased in both male and female patients after surgery, and was positively correlated to the PTH and ionized calcium values and inversely correlated to renal function before treatment. Uric Acid 19-24 parathyroid hormone Homo sapiens 120-123
9777464-5 1998 Chitosan encapsulated activated charcoal (ACCB) beads have been extensively investigated in our group for the removal of various toxins such as urea, creatinine, uric acid, bilirubin, etc. Uric Acid 162-171 acetyl-CoA carboxylase beta Homo sapiens 42-46
10071392-0 1998 Highly sensitive flow detection of uric acid based on an intermediate regeneration of uricase. Uric Acid 35-44 urate oxidase (pseudogene) Homo sapiens 86-93
9709003-1 1998 The oxidation of urate catalyzed by soybean urate oxidase was studied under single-turnover conditions using stopped-flow absorbance and fluorescence spectrophotometry. Uric Acid 17-22 uricase-2 isozyme 2 Glycine max 44-57
10071392-1 1998 The principle of the signal amplification of a uric acid sensor based on dithiothreitol (DTT)-mediated intermediate regeneration of uricase was applied to a flow-injection system with an immobilized uricase reactor and a DTT-containing carrier. Uric Acid 47-56 urate oxidase (pseudogene) Homo sapiens 132-139
10071392-1 1998 The principle of the signal amplification of a uric acid sensor based on dithiothreitol (DTT)-mediated intermediate regeneration of uricase was applied to a flow-injection system with an immobilized uricase reactor and a DTT-containing carrier. Uric Acid 47-56 urate oxidase (pseudogene) Homo sapiens 199-206
10071392-2 1998 Highly sensitive detection for nM to microM order of uric acid was achieved when 10 mM TRIS-HCl buffer (pH 10.0) containing 20 mM DTT was used as a carrier at 0.6 ml min-1 and 37 degrees C. The sensitivity of the uric acid was much improved over a batch method using a uricase membrane-coupling electrode, and the detection limit (ca. Uric Acid 53-62 CD59 molecule (CD59 blood group) Homo sapiens 166-171
10071392-2 1998 Highly sensitive detection for nM to microM order of uric acid was achieved when 10 mM TRIS-HCl buffer (pH 10.0) containing 20 mM DTT was used as a carrier at 0.6 ml min-1 and 37 degrees C. The sensitivity of the uric acid was much improved over a batch method using a uricase membrane-coupling electrode, and the detection limit (ca. Uric Acid 53-62 urate oxidase (pseudogene) Homo sapiens 269-276
9793264-2 1998 Soluble CD25 compared with the others sCD and the usual serum factors (albumin, lactate dehydrogenase, beta 2-microglobulin, uric acid and C-reactive protein), showed the strongest correlation with the Ann Arbor stage and the number of affected localizations. Uric Acid 125-134 interleukin 2 receptor subunit alpha Homo sapiens 8-12
9712345-11 1998 The observed parallel increases in homocysteine and uric acid levels in subjects with thermolabile MTHFR warrant further investigation. Uric Acid 52-61 methylenetetrahydrofolate reductase Homo sapiens 99-104
9605181-0 1998 Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis. Uric Acid 143-159 interleukin-8 Oryctolagus cuniculus 87-128
9782673-9 1998 Factor 2, which was mainly composed of isoflavonoids, was positively associated with creatinine and uric acid levels. Uric Acid 100-109 transcription termination factor 2 Homo sapiens 0-8
9588743-7 1998 In mIL-8RH(-/-) mice, urate crystals induced a proteinaceous leukocyte-poor exudate at 4 hours, despite crystal-induced activation of resident cells (documented by KC/GROalpha expression). Uric Acid 22-27 chemokine (C-X-C motif) receptor 2 Mus musculus 3-10
9588743-7 1998 In mIL-8RH(-/-) mice, urate crystals induced a proteinaceous leukocyte-poor exudate at 4 hours, despite crystal-induced activation of resident cells (documented by KC/GROalpha expression). Uric Acid 22-27 chemokine (C-X-C motif) ligand 1 Mus musculus 164-175
9588743-8 1998 CONCLUSION: Chemokines that bind the IL-8 receptor CXCR-2 are essential for the development of acute neutrophilic inflammation in response to urate crystals in the subcutaneous air pouch model. Uric Acid 142-147 chemokine (C-X-C motif) ligand 15 Mus musculus 37-41
9588743-8 1998 CONCLUSION: Chemokines that bind the IL-8 receptor CXCR-2 are essential for the development of acute neutrophilic inflammation in response to urate crystals in the subcutaneous air pouch model. Uric Acid 142-147 chemokine (C-X-C motif) receptor 2 Mus musculus 51-57
9714185-0 1998 Production and regulation of monocyte chemoattractant protein-1 in lipopolysaccharide- or monosodium urate crystal-induced arthritis in rabbits: roles of tumor necrosis factor alpha, interleukin-1, and interleukin-8. Uric Acid 90-106 C-C motif chemokine 2 Oryctolagus cuniculus 29-63
9706420-6 1998 The serum MMP-3 level in patients with SLE at admission showed direct correlations with serum uric acid, total cholesterol (p < 0.001), triglyceride, the white blood cell count, and the neutrophil count (p < 0.05), as well as inverse correlations with the total protein (p < 0.01), and IgG (p < 0.05). Uric Acid 94-103 matrix metallopeptidase 3 Homo sapiens 10-15
9627362-9 1998 Diversion of glycolytic intermediates toward R-5-P, PPRP, and uric acid will follow if there is diminished activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PDH), which is regulated by insulin. Uric Acid 62-71 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 119-159
9627362-9 1998 Diversion of glycolytic intermediates toward R-5-P, PPRP, and uric acid will follow if there is diminished activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PDH), which is regulated by insulin. Uric Acid 62-71 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 161-167
9627362-9 1998 Diversion of glycolytic intermediates toward R-5-P, PPRP, and uric acid will follow if there is diminished activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PDH), which is regulated by insulin. Uric Acid 62-71 insulin Homo sapiens 192-199
9588743-2 1998 Urate crystals induce different classes of neutrophil chemotaxins, including certain chemokines (e.g., interleukin-8 [IL-8], growth-related oncogene alpha [GROalpha]) that share CXCR-2 as a receptor. Uric Acid 0-5 chemokine (C-X-C motif) ligand 15 Mus musculus 103-116
9588743-2 1998 Urate crystals induce different classes of neutrophil chemotaxins, including certain chemokines (e.g., interleukin-8 [IL-8], growth-related oncogene alpha [GROalpha]) that share CXCR-2 as a receptor. Uric Acid 0-5 chemokine (C-X-C motif) ligand 15 Mus musculus 118-122
9588743-2 1998 Urate crystals induce different classes of neutrophil chemotaxins, including certain chemokines (e.g., interleukin-8 [IL-8], growth-related oncogene alpha [GROalpha]) that share CXCR-2 as a receptor. Uric Acid 0-5 chemokine (C-X-C motif) receptor 2 Mus musculus 178-184
9605181-2 1998 The production of TNFalpha in synovial fluids reached the peak at 2 hours after the intra-articular injection of monosodium urate (MSU) crystals. Uric Acid 113-129 tumor necrosis factor Oryctolagus cuniculus 18-26
9605181-2 1998 The production of TNFalpha in synovial fluids reached the peak at 2 hours after the intra-articular injection of monosodium urate (MSU) crystals. Uric Acid 131-134 tumor necrosis factor Oryctolagus cuniculus 18-26
9473245-0 1998 Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes. Uric Acid 0-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54
9586580-7 1998 The concentration (nmol/mg hair, y) of uric acid in hair correlated well with that in serum (mg/l, x): y=0.09x-0.12 (r=0.75, Syx=0.122, n=23). Uric Acid 39-48 pleckstrin homology and RhoGEF domain containing G5 Homo sapiens 125-128
9473245-4 1998 We found that MSU crystals, but not calcium pyrophosphate dihydrate (CPPD) crystals, induced COX-2, which correlated with the synthesis of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2). Uric Acid 14-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 93-98
9473245-10 1998 Taken together, these results implicate COX-2 in the development of MSU-induced inflammation. Uric Acid 68-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45
9461318-4 1998 RESULTS: In univariate analyses the concentration of fasting serum uric acid was negatively correlated to the insulin sensitivity index in both men (r2 = -0.25, P = 0.001) and women (r2 = -0.25, P < 0.001). Uric Acid 67-76 insulin Homo sapiens 110-117
9539195-6 1998 In the whole dataset, insulin resistance was directly related to BMI, the waist-to-hip ratio (WHR), endogenous glucose production, insulin secretion, and fasting serum triglycerides and uric acid concentrations. Uric Acid 186-195 insulin Homo sapiens 22-29
9486284-6 1998 Urate crystal administration reduced COX-1, but induced COX-2 expression in peritoneal cells. Uric Acid 0-5 cytochrome c oxidase I, mitochondrial Mus musculus 37-42
9486284-6 1998 Urate crystal administration reduced COX-1, but induced COX-2 expression in peritoneal cells. Uric Acid 0-5 cytochrome c oxidase II, mitochondrial Mus musculus 56-61
9487687-16 1998 The low uricase activities in sheep tissues appeared to explain the limited conversion of the intravenously administered [15N] uric acid to allantoin but did not explain the large quantities of allantoin excreted in urine (8.96 +/- 0.86 and 1.36 +/- 0.25 mmol d-1 for allantoin and uric acid, respectively). Uric Acid 127-136 uricase Ovis aries 8-15
9415647-0 1997 Monosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell line. Uric Acid 0-16 tumor necrosis factor Mus musculus 76-103
9398143-5 1997 More specifically, there is evidence to support the hypothesis that elevated plasma insulin concentrations may enhance renal sodium retention and decrease urinary uric acid clearance. Uric Acid 163-172 insulin Homo sapiens 84-91
9400833-3 1997 Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists. Uric Acid 193-209 Cbl proto-oncogene Homo sapiens 37-40
9396346-6 1997 The concentration(y, nmol/mg hair) of uric acid in hair correlated well with that in blood(x, g/l): y = 8.770x-0.123(r = 0.746, Syx = 0.122, n = 23). Uric Acid 38-47 pleckstrin homology and RhoGEF domain containing G5 Homo sapiens 128-131
9472456-6 1997 RESULTS: There was a significant correlation between elevated "true" fasting serum insulin level and various constituents of the insulin resistance syndrome, such as obesity, dyslipidemia (hypertriglyceridemia, increased apolipoprotein B and decreased high-density lipoprotein cholesterol and apolipoprotein A1 concentrations), increased serum glucose, uric acid levels, and plasminogen activator inhibitor type I concentration, as well as increased frequency of diabetes. Uric Acid 353-362 insulin Homo sapiens 83-90
21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Uric Acid 181-190 xanthine dehydrogenase Homo sapiens 26-48
21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Uric Acid 181-190 xanthine dehydrogenase Homo sapiens 50-53
21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Uric Acid 181-190 xanthine dehydrogenase Homo sapiens 92-98
21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Uric Acid 181-190 xanthine dehydrogenase Homo sapiens 95-98
9364609-1 1997 Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 0-30
9364609-1 1997 Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. Uric Acid 49-58 xanthine dehydrogenase Homo sapiens 32-35
9405981-7 1997 Plasma uric acid was inversely correlated to glycemia (r = -0.34, p < 0.05) and to HbA1 c (r = -0.56, p < 0.0008) and fractional excretion of uric acid was directly correlated to glycemia (r = 0.39, p < 0.03) and HbA1 c (r = 0.73, p < 0.00005). Uric Acid 7-16 hemoglobin subunit alpha 1 Homo sapiens 86-90
9405981-7 1997 Plasma uric acid was inversely correlated to glycemia (r = -0.34, p < 0.05) and to HbA1 c (r = -0.56, p < 0.0008) and fractional excretion of uric acid was directly correlated to glycemia (r = 0.39, p < 0.03) and HbA1 c (r = 0.73, p < 0.00005). Uric Acid 7-16 hemoglobin subunit alpha 1 Homo sapiens 222-226
18966880-0 1997 Immobilization of uricase to gas diffusion carbon felt by electropolymerization of aniline and its application as an enzyme reactor for uric acid sensor. Uric Acid 136-145 urate oxidase (pseudogene) Homo sapiens 18-25
9350587-6 1997 The serum hepatocyte growth factor concentrations were also correlated significantly to the serum uric acid concentrations (r = 0.230, P = 0.015) and erythrocyte counts (r = 0.299, P = 0.001), but not to the systolic and diastolic blood pressures, and other physical and humoral parameters. Uric Acid 98-107 hepatocyte growth factor Homo sapiens 10-34
9335313-0 1997 Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8. Uric Acid 15-31 interleukin-8 Oryctolagus cuniculus 104-117
9335313-3 1997 Thus, we investigate the pathophysiological role of IL-8 in an experimental model of acute gout, monosodium urate (MSU) crystal-induced arthritis in rabbits. Uric Acid 97-113 interleukin-8 Oryctolagus cuniculus 52-56
18966880-1 1997 Electropolymerizations of aniline and pyrrole solutions containing uricase at a neutral pH was performed to immobilize the enzyme on the surface of the gas diffusion carbon felt, and a selective uric acid sensor was fabricated by combining immobilized enzyme carbon felt and an oxygen electrode with oxygen gas permeable membrane. Uric Acid 195-204 urate oxidase (pseudogene) Homo sapiens 67-74
9290400-9 1997 In stepwise regression analysis, uric acid emerged as the only predictor of maximum blood flow (standardised coefficient = -0.83 (P < 0.001), R2 = 0.68 (P < 0.001)), independently of diuretic dose, age, body mass index, plasma creatinine, fasting and IVGTT glucose and insulin, insulin sensitivity, maximum oxygen uptake and exercise time during the treadmill exercise test, and alcohol intake. Uric Acid 33-42 insulin Homo sapiens 275-282
9228014-6 1997 OAT1 displayed remarkably wide substrate selectivity, covering endogenous substrates such as cyclic nucleotides, a prostaglandin and uric acid, and a variety of drugs with different structures (e.g. antibiotics, a nonsteroidal anti-inflammatory drug, diuretics, an antineoplastic drug, and a uricosuric drug). Uric Acid 133-142 solute carrier family 22 member 6 Rattus norvegicus 0-4
23604305-3 1997 XDH acts on these same substrates but utilizes NAD as a cofactor to produce NADH instead of O2 (-) and uric acid. Uric Acid 104-113 xanthine dehydrogenase Homo sapiens 0-3
9182888-2 1997 TNF-alpha in the 10-2000 pM or GM-CSF in the 2-200 pM concentration range caused the concentration-dependent amplification of neutrophil chemiluminescence responses to both calcium pyrophosphate dihydrate (CPPD) and monosodium urate monohydrate (MSUM) crystals. Uric Acid 216-244 tumor necrosis factor Homo sapiens 0-9
9377725-8 1997 Insulin antinatriuresis is accompanied by a reduction in the urinary excretion of uric acid. Uric Acid 82-91 insulin Homo sapiens 0-7
9192673-6 1997 In L-Arg-depleted macrophages iNOS generates both O-2 and NO that interact to form the potent oxidant peroxynitrite (ONOO-), which was detected by luminol luminescence and whose formation was blocked by superoxide dismutase, urate, or L-Arg. Uric Acid 225-230 nitric oxide synthase 2, inducible Mus musculus 30-34
9182888-2 1997 TNF-alpha in the 10-2000 pM or GM-CSF in the 2-200 pM concentration range caused the concentration-dependent amplification of neutrophil chemiluminescence responses to both calcium pyrophosphate dihydrate (CPPD) and monosodium urate monohydrate (MSUM) crystals. Uric Acid 216-244 colony stimulating factor 2 Homo sapiens 31-37
9182888-2 1997 TNF-alpha in the 10-2000 pM or GM-CSF in the 2-200 pM concentration range caused the concentration-dependent amplification of neutrophil chemiluminescence responses to both calcium pyrophosphate dihydrate (CPPD) and monosodium urate monohydrate (MSUM) crystals. Uric Acid 246-250 tumor necrosis factor Homo sapiens 0-9
9182888-2 1997 TNF-alpha in the 10-2000 pM or GM-CSF in the 2-200 pM concentration range caused the concentration-dependent amplification of neutrophil chemiluminescence responses to both calcium pyrophosphate dihydrate (CPPD) and monosodium urate monohydrate (MSUM) crystals. Uric Acid 246-250 colony stimulating factor 2 Homo sapiens 31-37
9179544-8 1997 tPA levels were correlated with age and the plasma levels of glucose and uric acid (P < 0.05); this correlation with glucose may explain the high levels associated with diabetes, whereas the age association might account not only for the differences observed between group NDHL and the younger control group but also for the higher levels in the postmenopausal women. Uric Acid 73-82 plasminogen activator, tissue type Homo sapiens 0-3
9152657-10 1997 In multivariate regression analysis, serum uric acid concentrations emerged as a significant predictor of MVO2, exercise time (both P < 0.001,) VE-VCO2 slope and NYHA functional class (both P < 0.02), independent of diuretic dose, age, body mass index, serum creatinine, alcohol intake, plasma insulin levels, and insulin sensitivity index. Uric Acid 43-52 insulin Homo sapiens 300-307
9152657-10 1997 In multivariate regression analysis, serum uric acid concentrations emerged as a significant predictor of MVO2, exercise time (both P < 0.001,) VE-VCO2 slope and NYHA functional class (both P < 0.02), independent of diuretic dose, age, body mass index, serum creatinine, alcohol intake, plasma insulin levels, and insulin sensitivity index. Uric Acid 43-52 insulin Homo sapiens 320-327
9237784-4 1997 C-peptide levels were significantly (P < 0.05) correlated with systolic (r = 0.21) and diastolic blood pressure (r = 0.19), BMI (r = 0.21), high density lipoprotein (HDL) (r = -0.22), non-HDL-cholesterol (r = 0.23), apolipoprotein B (r = 0.29), log of triglycerides (r = 0.39) and uric acid (r = 0.35). Uric Acid 284-293 insulin Homo sapiens 0-9
9237784-5 1997 The C-peptide/bloodsugar ratio had statistically significant correlations with known duration of diabetes (r = -0.23), diastolic blood pressure (r = 0.21), body mass index (BMI) (r = 0.22), log of triglycerides (r = 0.23) and uric acid (r = 0.36). Uric Acid 226-235 insulin Homo sapiens 4-13
9122229-5 1997 Significant therapeutic effects were seen with the inhibitor of iNOS induction, tricyclodecan-9-xyl-xanthogenate, a nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, and a peroxynitrite scavenger, uric acid. Uric Acid 227-236 nitric oxide synthase 2 Homo sapiens 64-68
9128279-2 1997 Experimental studies have revealed two main sources of these metabolites: 1) the oxidation of hypoxanthine to xanthine and on to uric acid by the oxidase form of xanthine oxidoreductase and 2) neutrophils accumulating in ischemic and reperfused tissue. Uric Acid 129-138 xanthine dehydrogenase Homo sapiens 162-185
9002961-9 1997 Hyperuricemia induced by repeated administrations of uric acid in normal mice led to an increased TNF production after LPS. Uric Acid 53-62 tumor necrosis factor Mus musculus 98-101
10374288-8 1997 The insulin resistance was positively correlated with serum uric acid in women (P < 0.05), but not in men (P > 0.05). Uric Acid 60-69 insulin Homo sapiens 4-11
9034995-3 1997 RESULTS: Wortmannin and LY 294002, 2 selective inhibitors of PI 3-kinase, were shown to inhibit neutrophil activation induced by plasma opsonized crystals of calcium pyrophosphate dihydrate (CPPD) [both monoclinic (M) and triclinic (T) forms] and monosodium urate monohydrate (MSUM). Uric Acid 247-275 peptidase inhibitor 3 Homo sapiens 61-65
9088862-6 1997 Multiple linear regression analysis confirmed that plasma insulin was independently correlated with plasma triglycerides and, to a lesser extent, with blood pressure and uric acid concentration. Uric Acid 170-179 insulin Homo sapiens 58-65
8995305-7 1997 Based on the wide tissue distribution of the mRNA for UAT we propose that UAT provides the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Uric Acid 111-116 galectin 9 Rattus norvegicus 54-57
8995305-7 1997 Based on the wide tissue distribution of the mRNA for UAT we propose that UAT provides the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Uric Acid 111-116 galectin 9 Rattus norvegicus 74-77
8995305-7 1997 Based on the wide tissue distribution of the mRNA for UAT we propose that UAT provides the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Uric Acid 154-159 galectin 9 Rattus norvegicus 54-57
8995305-7 1997 Based on the wide tissue distribution of the mRNA for UAT we propose that UAT provides the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Uric Acid 154-159 galectin 9 Rattus norvegicus 74-77
8986933-15 1996 The changes in the lipid profile and in uric acid levels paralleled the changes in insulin sensitivity. Uric Acid 40-49 insulin Homo sapiens 83-90
9296445-11 1997 The same paradoxical effect was found when isolated LDL was incubated with uric acid in the presence of human serum albumin (HSA) and Cu. Uric Acid 75-84 albumin Homo sapiens 110-136
9296445-12 1997 The incubation of HSA with reducing agents such as uric acid or bilirubin in the presence of high Cu concentrations, produces a "peroxidase-like" activity, capable of breaking down hydrogen peroxide as well as lipid hydroperoxides. Uric Acid 51-60 albumin Homo sapiens 18-21
9007155-8 1996 A number of statistically significant but low correlations (-0.32 to 0.24) were found between plasma fibrinogen and high density lipoprotein cholesterol (HDL-C) as a percentage of total cholesterol, triglycerides, blood glucose, uric acid, blood pressure, Quetelet index and sports activity. Uric Acid 229-238 fibrinogen beta chain Homo sapiens 101-111
9038589-12 1997 Neutrophil CD11b was positively correlated with plasma uric acid (r = 0.44, P = 0.04) in women with pre-eclampsia, suggesting that the extent of neutrophil activation correlates with disease severity. Uric Acid 55-64 integrin subunit alpha M Homo sapiens 11-16
8968852-6 1996 IGFBP-2 was associated with several metabolic parameters: it showed an inverse correlation with uric acid and triglyceride levels. Uric Acid 96-105 insulin like growth factor binding protein 2 Homo sapiens 0-7
9008022-8 1996 In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion. Uric Acid 147-156 O-GlcNAcase Homo sapiens 25-28
8976095-3 1996 The ultimate degradative product of purine nucleoside is uric acid, which is a depleted product with the absence of PNP activity. Uric Acid 57-66 purine nucleoside phosphorylase Homo sapiens 116-119
8976106-2 1996 Several clinical studies revealed that insulin resistance and/or hyperinsulinaemia is associated with hypertension and higher plasma concentrations of uric acid, triglyceride and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations. Uric Acid 151-160 insulin Homo sapiens 39-46
8976107-3 1996 Serum uric acid level increased more in Type IIb with elevated lipoprotein lipase (LPL) than those with low or normal LPL. Uric Acid 6-15 lipoprotein lipase Homo sapiens 63-81
8976107-3 1996 Serum uric acid level increased more in Type IIb with elevated lipoprotein lipase (LPL) than those with low or normal LPL. Uric Acid 6-15 lipoprotein lipase Homo sapiens 83-86
8976107-4 1996 Elevated LPL may be involved in the retarded uric acid clearance due to increased free fatty acids (FFA) in the serum, resulting in the elevation of uric acid and may be linked to the obesity-insulin resistance syndrome. Uric Acid 45-54 lipoprotein lipase Homo sapiens 9-12
8976107-4 1996 Elevated LPL may be involved in the retarded uric acid clearance due to increased free fatty acids (FFA) in the serum, resulting in the elevation of uric acid and may be linked to the obesity-insulin resistance syndrome. Uric Acid 149-158 lipoprotein lipase Homo sapiens 9-12
8976108-2 1996 Our data showed a low, but significant correlation between serum uric acid concentration and the degree of insulin resistance (GIR) estimated by euglycemic hyperinsulinemic clamp method in 67 subjects with combined normal glucose tolerance and IGT(r = -0.278, p < 0.05). Uric Acid 65-74 insulin Homo sapiens 107-114
9008022-8 1996 In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion. Uric Acid 147-156 O-GlcNAcase Homo sapiens 98-101
8895731-5 1996 To test whether H2O2 generated by other peroxisomal oxidases can also lead to transformation, a full-length cDNA encoding rat urate oxidase (UOX), which oxidizes uric acid to allantoin and in the process generates H2O2, was introduced into African green monkey kidney cells (CV-1 cells) under the control of constitutively active human peroxisomal fatty acyl-CoA oxidase gene promoter. Uric Acid 162-171 urate oxidase Rattus norvegicus 126-139
8895731-5 1996 To test whether H2O2 generated by other peroxisomal oxidases can also lead to transformation, a full-length cDNA encoding rat urate oxidase (UOX), which oxidizes uric acid to allantoin and in the process generates H2O2, was introduced into African green monkey kidney cells (CV-1 cells) under the control of constitutively active human peroxisomal fatty acyl-CoA oxidase gene promoter. Uric Acid 162-171 urate oxidase Rattus norvegicus 141-144
8895731-7 1996 Increased levels of H2O2 were found when cells stably expressing UOX were exposed to the substrate uric acid. Uric Acid 99-108 urate oxidase Rattus norvegicus 65-68
8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 208-217 insulin Homo sapiens 249-256
8903395-11 1996 The finding of this low percentage of xanthine oxidase further stresses that the main function of xanthine oxidoreductase in the liver is not the production of superoxide anion radicals and/or hydrogen peroxide but rather the metabolism of xanthine to uric acid, which can act as a potent antioxidant. Uric Acid 252-261 xanthine dehydrogenase Rattus norvegicus 98-121
8981120-7 1996 Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Uric Acid 6-15 sex hormone binding globulin Homo sapiens 57-87
8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 47-56 insulin Homo sapiens 76-83
8981120-7 1996 Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Uric Acid 6-15 sex hormone binding globulin Homo sapiens 89-93
8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 208-217 insulin Homo sapiens 76-83
8981120-7 1996 Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Uric Acid 6-15 insulin Homo sapiens 154-161
8923153-10 1996 In multivariate regression analysis, serum triglycerides, BMI and WHR (at borderline significance) were independent positive predictors of uric acid (R2 of the model 0.122, P < 0.001), while fasting insulin concentration did not give any independent contribution to explain the variability uric acid levels. Uric Acid 139-148 insulin Homo sapiens 202-209
8981120-7 1996 Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Uric Acid 6-15 sex hormone binding globulin Homo sapiens 194-198
8923162-4 1996 In conclusion, in this group of subjects the serum uric acid values were directly related to insulin resistance independently of age, sex, excess body weight, fat distribution and blood pressure. Uric Acid 51-60 insulin Homo sapiens 93-100
8862220-7 1996 In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2.67 +/- 0.12 to 1.86 +/- .14 mumol/min/1.73 m2, P = .0001), sodium (184 +/- 12 to 137 +/- 14 mumol/min/1.73 m2, P = .0001), and potassium (81 +/- 7 to 48 +/- 4 mumol/ min/1.73 m2, P = .0001). Uric Acid 88-97 CD59 molecule (CD59 blood group) Homo sapiens 135-140
8906205-9 1996 Uric acid levels were higher in G-2 (431 +/- 274 mumoles/1) than in G-1 (224 +/- 188) at 5 minutes after aortic clamping, and catalase activity was greater in G-2 (294 +/- 55 KU/1) than in G-1 (118 +/- 47) at time of reperfusion. Uric Acid 0-9 crystallin gamma E, pseudogene Homo sapiens 32-35
8959528-0 1996 The relationship between insulin, glucose and serum uric acid and their contribution to the progression of renal damage in patients with primary glomerulonephritis. Uric Acid 52-61 insulin Homo sapiens 25-32
8862220-0 1996 Effect of insulin on renal sodium and uric acid handling in essential hypertension. Uric Acid 38-47 insulin Homo sapiens 10-17
8862220-7 1996 In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2.67 +/- 0.12 to 1.86 +/- .14 mumol/min/1.73 m2, P = .0001), sodium (184 +/- 12 to 137 +/- 14 mumol/min/1.73 m2, P = .0001), and potassium (81 +/- 7 to 48 +/- 4 mumol/ min/1.73 m2, P = .0001). Uric Acid 88-97 CD59 molecule (CD59 blood group) Homo sapiens 199-204
8862220-7 1996 In contrast, hyperinsulinemia caused a significant decrease in the urinary excretion of uric acid (2.67 +/- 0.12 to 1.86 +/- .14 mumol/min/1.73 m2, P = .0001), sodium (184 +/- 12 to 137 +/- 14 mumol/min/1.73 m2, P = .0001), and potassium (81 +/- 7 to 48 +/- 4 mumol/ min/1.73 m2, P = .0001). Uric Acid 88-97 CD59 molecule (CD59 blood group) Homo sapiens 199-204
8862220-9 1996 Insulin-induced changes in urate excretion were coupled (r = 0.55, P < .0001) to the respective changes in sodium excretion. Uric Acid 27-32 insulin Homo sapiens 0-7
8862220-10 1996 In hypertensive patients, higher uric acid levels and lower renal urate clearance rates cluster with insulin resistance and dyslipidemia. Uric Acid 33-42 insulin Homo sapiens 101-108
8862220-10 1996 In hypertensive patients, higher uric acid levels and lower renal urate clearance rates cluster with insulin resistance and dyslipidemia. Uric Acid 66-71 insulin Homo sapiens 101-108
8670330-0 1996 Inhibition and prevention of monosodium urate monohydrate crystal-induced acute inflammation in vivo by transforming growth factor beta1. Uric Acid 29-57 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 131-136
8876844-7 1996 The uric acid level was positively correlated in both sexes with a variety of health-related factors, most notably body mass index, creatinine, triglycerides, diuretic use, alcohol intake, hypertension, diabetes, and insulin levels. Uric Acid 4-13 insulin Homo sapiens 217-224
8670330-1 1996 OBJECTIVE: We investigated the effects of transforming growth factor beta 1 (TGF beta 1) on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in vivo. Uric Acid 92-120 transforming growth factor beta 1 Homo sapiens 42-75
8670330-1 1996 OBJECTIVE: We investigated the effects of transforming growth factor beta 1 (TGF beta 1) on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in vivo. Uric Acid 92-120 transforming growth factor beta 1 Homo sapiens 77-87
8670330-1 1996 OBJECTIVE: We investigated the effects of transforming growth factor beta 1 (TGF beta 1) on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in vivo. Uric Acid 122-125 transforming growth factor beta 1 Homo sapiens 77-87
8829220-1 1996 Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Uric Acid 76-85 xanthine dehydrogenase Homo sapiens 0-30
8829220-1 1996 Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Uric Acid 76-85 xanthine dehydrogenase Homo sapiens 32-35
9026580-4 1996 Uric acid was marked by indirect method with uricase. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 45-52
8635236-6 1996 The decrease in mitochondrial respiration in response to LPS and IFN-gamma stimulation was inhibited by the ONOO- scavenger uric acid (100 mumol/L) and by inhibitors of iNOS. Uric Acid 124-133 interferon gamma Rattus norvegicus 65-74
8656229-2 1996 In an age-stratified Cox regression model, high serum uric acid (quartile 4 [>6.7 mg/dl], relative to quartile 1 [<5.0 mg/dl]) was a significant predictor of definite CHD (RR = 1.33; 95% confidence interval = 1.08-1.63; p = 0.006). Uric Acid 54-63 cytochrome c oxidase subunit 8A Homo sapiens 21-24
8784924-1 1996 Xanthine dehydrogenase and sulfite oxidase from chicken liver are oxomolybdenum enzymes which catalyze the oxidation of xanthine to uric acid and sulfite to sulfate, respectively. Uric Acid 132-141 xanthine dehydrogenase Gallus gallus 0-22
8784924-1 1996 Xanthine dehydrogenase and sulfite oxidase from chicken liver are oxomolybdenum enzymes which catalyze the oxidation of xanthine to uric acid and sulfite to sulfate, respectively. Uric Acid 132-141 sulfite oxidase Gallus gallus 27-42
8624635-3 1996 injected radiolabelled anti-E-selectin monoclonal antibody 1.2b6 together with differentially radiolabelled neutrophils, mononuclear cells and albumin, we have characterized the expression of E-selectin in relation to leucocyte traffic, microvascular permeability and clinical sequelae following intracutaneous injection of monosodium urate crystals. Uric Acid 324-340 selectin E Homo sapiens 192-202
8591845-0 1996 The effect of mannitol and secretin on the biliary transport of urate in humans. Uric Acid 64-69 secretin Homo sapiens 27-35
8591845-6 1996 When compared with basal state values, procine and synthetic secretin induced a significant increase in mean urate clearance (P < .001) because of a significant increase in mean bile flow (P < .001), whereas the mean biliary urate concentration significantly decreased (P < .001) with a concomitant decrease in the mean serum urate concentration (P < .02). Uric Acid 109-114 secretin Homo sapiens 61-69
8591845-6 1996 When compared with basal state values, procine and synthetic secretin induced a significant increase in mean urate clearance (P < .001) because of a significant increase in mean bile flow (P < .001), whereas the mean biliary urate concentration significantly decreased (P < .001) with a concomitant decrease in the mean serum urate concentration (P < .02). Uric Acid 231-236 secretin Homo sapiens 61-69
8591845-6 1996 When compared with basal state values, procine and synthetic secretin induced a significant increase in mean urate clearance (P < .001) because of a significant increase in mean bile flow (P < .001), whereas the mean biliary urate concentration significantly decreased (P < .001) with a concomitant decrease in the mean serum urate concentration (P < .02). Uric Acid 231-236 secretin Homo sapiens 61-69
8738818-4 1996 Therefore, the urate clearance rate was measured in seven volunteers with 1-desamino-8-D-arginine vasopressin (dDAVP)-induced hyponatremia, with dDVAP stimulating exclusively the V2 receptors (Group I), and in six patients with SIADH (Group II) during both normo- and hyponatremia. Uric Acid 15-20 arginine vasopressin Homo sapiens 98-109
8738818-8 1996 Additionally, the administration of a potent V1-receptor agonist (triglycyl-lysine-vasopressin) in a patient with central diabetes insipidus with preexisting dDAVP-induced hyponatremia produced a rapid increase of urate clearance. Uric Acid 214-219 arginine vasopressin Homo sapiens 83-94
8975220-2 1996 Elevated serum uric acid level and higher urinary excretion was found only in children with IgAN during exacerbation of the disease. Uric Acid 15-24 IGAN1 Homo sapiens 92-96
8979621-3 1996 Level of serum uric acid in mild PIH was significantly higher than normotensive women (P). Uric Acid 15-24 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 33-36
8979621-4 1996 In severe PIH, the mean serum uric acid levels were 6.65 +/- 0.60, 8.24 +/- 1.09 mg% in antepartum and at delivery respectively which was significantly more than control group and mild PIH group women (P). Uric Acid 30-39 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 10-13
8979621-4 1996 In severe PIH, the mean serum uric acid levels were 6.65 +/- 0.60, 8.24 +/- 1.09 mg% in antepartum and at delivery respectively which was significantly more than control group and mild PIH group women (P). Uric Acid 30-39 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 185-188
8979621-6 1996 Serum uric acid level of 5.5 mg or more was observed to be an indicator of PIH. Uric Acid 6-15 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 75-78
8979621-7 1996 Levels of serum uric acid did show a high positive correlation with the severity of PIH in relation to hypertension and proteinuria. Uric Acid 16-25 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 84-87
9026581-2 1996 Uric acid was marked by indirect method with uricase. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 45-52
8772427-0 1996 Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. Uric Acid 0-16 integrin subunit beta 2 Homo sapiens 60-64
8572024-4 1996 Xanthine dehydrogenase/oxidase produces uric acid. Uric Acid 40-49 xanthine dehydrogenase Homo sapiens 0-30
9102081-7 1996 On the contrary, higher Ca++ and UA concentrations directly or indirectly inhibit hormones and the functional activity of the adrenal cortex, testes and lower the levels of EE, some enzymes, and total protein, 2) Calcitonin (CT) and parathyroid hormone (PTH) seem to be factors favouring the activation of insulin that enhances the membranous transport not only of glucose, but some other saccharides together with EE. Uric Acid 33-35 parathyroid hormone Homo sapiens 233-252
8558429-9 1996 Direct determination of the effects of angiotensin II on urate and Cl- transport across colonic tissues from control animals revealed a significant angiotensin II stimulation of urate secretion. Uric Acid 57-62 angiotensinogen Rattus norvegicus 39-53
8558429-9 1996 Direct determination of the effects of angiotensin II on urate and Cl- transport across colonic tissues from control animals revealed a significant angiotensin II stimulation of urate secretion. Uric Acid 57-62 angiotensinogen Rattus norvegicus 148-162
8558429-9 1996 Direct determination of the effects of angiotensin II on urate and Cl- transport across colonic tissues from control animals revealed a significant angiotensin II stimulation of urate secretion. Uric Acid 178-183 angiotensinogen Rattus norvegicus 39-53
8558429-9 1996 Direct determination of the effects of angiotensin II on urate and Cl- transport across colonic tissues from control animals revealed a significant angiotensin II stimulation of urate secretion. Uric Acid 178-183 angiotensinogen Rattus norvegicus 148-162
8558420-1 1996 The angiotensin II (AII) antagonist, losartan, increases uric acid excretion when administered to humans. Uric Acid 57-66 angiotensinogen Homo sapiens 4-18
8558420-1 1996 The angiotensin II (AII) antagonist, losartan, increases uric acid excretion when administered to humans. Uric Acid 57-66 angiotensinogen Homo sapiens 20-23
8558420-7 1996 The other AII antagonists also inhibited urate uptake but were 6-8-fold less potent than losartan with IC50 values of EXP 3174 (65 +/- 13 microM), eprosartan (60 +/- 7.0 microM) and SB 203220 (74 +/- 12.5 microM). Uric Acid 41-46 angiotensinogen Rattus norvegicus 10-13
9463115-4 1996 Uric acid was marked by indirect method with uricase. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 45-52
9463116-2 1996 Uric acid was marked by indirect method with uricase. Uric Acid 0-9 urate oxidase (pseudogene) Homo sapiens 45-52
9102081-7 1996 On the contrary, higher Ca++ and UA concentrations directly or indirectly inhibit hormones and the functional activity of the adrenal cortex, testes and lower the levels of EE, some enzymes, and total protein, 2) Calcitonin (CT) and parathyroid hormone (PTH) seem to be factors favouring the activation of insulin that enhances the membranous transport not only of glucose, but some other saccharides together with EE. Uric Acid 33-35 parathyroid hormone Homo sapiens 254-257
8866908-7 1995 In the insulin-resistant group, 50% showed elevated levels of serum triglycerides (> 2.0 mmol/l), 50% had abdominal obesity (waist:hip ratio > 0.95), 20% had elevated levels of serum uric acid (> 400 mumol/l) and 48% had low high-density lipid (HDL)-cholesterol levels (< 1.0 mmol/l). Uric Acid 189-198 insulin Homo sapiens 7-14
7484901-3 1995 After we classified patients according to the quartiles of serum insulin level, we noted in the top quartile the presence of practically all manifestations of insulin resistance syndrome in persons of both sexes (e.g., increased waist/hip ratio, body mass index, glucose, uric acid, triglycerides, apolipoprotein B and decreased high-density lipoprotein cholesterol levels as well as apolipoprotein A-I/B ratios, and so forth). Uric Acid 272-281 insulin Homo sapiens 65-72
7580053-5 1995 Citrate and urate inhibit the iron-ceruloplasmin-dependent ascorbate oxidation by chelating ferric ions. Uric Acid 12-17 ceruloplasmin Homo sapiens 35-48
7485529-4 1995 In addition, the TNF-induced effects were prevented by superoxide dismutase (10 U/ml), which removes O2-, and by urate (0.5 mM) and L-cysteine (3 mM), putative scavengers of ONOO-. Uric Acid 113-118 tumor necrosis factor Homo sapiens 17-20
7547116-6 1995 Similarly, E-selectin was found to be high in joints with monosodium urate crystal-induced synovitis. Uric Acid 58-74 selectin E Homo sapiens 11-21
7473683-3 1995 Since both the uricase-like renal protein and hepatic uricase can transport urate, reconstitution studies were performed to further characterize the mechanism by which uricase may function as a transport protein. Uric Acid 76-81 urate oxidase Rattus norvegicus 54-61
7473683-3 1995 Since both the uricase-like renal protein and hepatic uricase can transport urate, reconstitution studies were performed to further characterize the mechanism by which uricase may function as a transport protein. Uric Acid 76-81 urate oxidase Rattus norvegicus 54-61
7473683-6 1995 Following fusion of uricase with the bilayer, single channel activity was evident: the reconstituted channel rectified with a mean slope conductance of 8 pS, displayed voltage sensitivity, and demonstrated a marked selectivity for urate relative to K+ and Cl-. Uric Acid 231-236 urate oxidase Rattus norvegicus 20-27
7473683-7 1995 The channel was more selective to oxonate, an inhibitor of both enzymatic uricase activity and urate transport, than urate and it was equally selective to urate and pyrazinoate, an inhibitor of urate transport. Uric Acid 95-100 urate oxidase Rattus norvegicus 74-81
7473683-7 1995 The channel was more selective to oxonate, an inhibitor of both enzymatic uricase activity and urate transport, than urate and it was equally selective to urate and pyrazinoate, an inhibitor of urate transport. Uric Acid 117-122 urate oxidase Rattus norvegicus 74-81
7473683-7 1995 The channel was more selective to oxonate, an inhibitor of both enzymatic uricase activity and urate transport, than urate and it was equally selective to urate and pyrazinoate, an inhibitor of urate transport. Uric Acid 117-122 urate oxidase Rattus norvegicus 74-81
7673115-9 1995 Although Me2SO, sodium formate, and mannitol had no protective effect, iron chelators, thiourea and urate protected the cells against the SIN-1 plus Cu,Zn-SOD-mediated cytotoxicity. Uric Acid 100-105 superoxide dismutase 1 Homo sapiens 155-158
7557840-8 1995 The levels of serum UA (p < 0.001) and serum triglycerides (TG) (p < 0.01) in the subgroup with hyperinsulinemia were significantly higher than in the subgroup with normal insulin levels. Uric Acid 20-22 insulin Homo sapiens 107-114
7557840-9 1995 By linear regression analyses, the serum UA concentration was positively correlated with peak plasma insulin level (r = 0.31, p < 0.001), and BMI (r = 0.20, p < 0.01), but not with age, DOI, or peak glucose. Uric Acid 41-43 insulin Homo sapiens 101-108
7733945-7 1995 The ONOO- scavenger uric acid (UA, 1 mM) did not prevent the decrease in viability in response to SNAP, DN or pyrogallol, but significantly prevented the decrease in cell viability in response to ONOO-, to the combination of SNAP and pyrogallol, and to SIN-1, a compound that simultaneously generates NO and O2-. Uric Acid 20-29 MAPK associated protein 1 Homo sapiens 253-258
7768579-4 1995 Elevated NAG activity showed an independent relationship to future hypertension (P < .005) after adjustments for age, sex, baseline blood pressure (systolic, diastolic, or mean), uric acid level, and the sum of skinfolds. Uric Acid 182-191 O-GlcNAcase Homo sapiens 9-12
7732797-7 1995 Serum urate, which is correlated with clinical outcome of pregnancy, increased during the study period and correlated directly with von Willebrand Factor and PAI-1 antigen, respectively. Uric Acid 6-11 serpin family E member 1 Homo sapiens 158-163
7733945-8 1995 The decrease in mitochondrial respiration in response to LPS and IFN was also inhibited by UA as well as by NG-methyl-arginine, an inhibitor of NOS. Uric Acid 91-93 interferon alpha 1 Homo sapiens 65-68
7732797-8 1995 There was an inverse correlation between the concentrations of placenta-derived PAI-2 antigen and urate. Uric Acid 98-103 serpin family B member 2 Homo sapiens 80-85
8693203-2 1995 Concentration of uric acid was determined by Acc-Uric test in which the normal values are 200 to 420 mumol/L in males and 140 to 340 mumol/L in females. Uric Acid 17-26 acetyl-CoA carboxylase alpha Homo sapiens 45-48
7768225-6 1995 Comparisons of blood urea nitrogen (BUN) and uric acid by genotype indicated elevated levels among ALAD-2 individuals (p = 0.03 and 0.07, respectively). Uric Acid 45-54 aminolevulinate dehydratase Homo sapiens 99-103
7768225-8 1995 Associations of BUN and uric acid levels with ALAD-2 were of borderline statistical significance in these models (p = 0.06 and 0.07). Uric Acid 24-33 aminolevulinate dehydratase Homo sapiens 46-50
7840165-0 1995 Effect of insulin on uric acid excretion in humans. Uric Acid 21-30 insulin Homo sapiens 10-17
7840165-1 1995 Although hyperuricemia is a frequent finding in insulin-resistant states, insulin"s effect on renal uric acid (UA) handling is not known. Uric Acid 100-109 insulin Homo sapiens 74-81
7840165-1 1995 Although hyperuricemia is a frequent finding in insulin-resistant states, insulin"s effect on renal uric acid (UA) handling is not known. Uric Acid 111-113 insulin Homo sapiens 74-81
7840165-2 1995 In 20 healthy volunteers, diastolic blood pressure, body weight, and fasting plasma insulin were positively (and age was negatively) related to fasting plasma UA concentrations, together accounting for 53% of their variability. Uric Acid 159-161 insulin Homo sapiens 84-91
7840165-6 1995 Fractional UA excretion was related to Na fractional excretion under basal conditions (r = 0.59, P < 0.01) and during the insulin period (r = 0.53, P < 0.02). Uric Acid 11-13 insulin Homo sapiens 125-132
7840165-7 1995 Furthermore, the insulin-induced changes in fractional UA and Na excretion correlated with one another (r = 0.66, P < 0.001). Uric Acid 55-57 insulin Homo sapiens 17-24
8821625-1 1995 Humans and hominoid primates lack the enzyme urate oxidase, which catalyzes the oxidation of uric acid to allantoin. Uric Acid 93-102 urate oxidase Rattus norvegicus 45-58
7723681-3 1995 However, data on the effects of nibbling on serum lipids throughout the day are not available, nor is it known how nibbling affects serum uric acid as a further insulin-related risk factor for cardiovascular disease. Uric Acid 138-147 insulin Homo sapiens 161-168
7712531-11 1995 The activity of superoxide dismutase (SOD) in diabetic group increased from 598 +/- 105 to 696 +/- 103 U/g of hemoglobin (p < 0.01), the activity of glutathion peroxidase (GSHPx) did not change, malondialdehyde (MDA) decreased from 7.1 +/- 1.1 to 5.8 +/- 1.1 mumol/L (p < 0.01) and uric acid decreased from 261 +/- 83 to 236 +/- 96 mumol/L (p < 0.01). Uric Acid 288-297 superoxide dismutase 1 Homo sapiens 16-36
7712531-11 1995 The activity of superoxide dismutase (SOD) in diabetic group increased from 598 +/- 105 to 696 +/- 103 U/g of hemoglobin (p < 0.01), the activity of glutathion peroxidase (GSHPx) did not change, malondialdehyde (MDA) decreased from 7.1 +/- 1.1 to 5.8 +/- 1.1 mumol/L (p < 0.01) and uric acid decreased from 261 +/- 83 to 236 +/- 96 mumol/L (p < 0.01). Uric Acid 288-297 superoxide dismutase 1 Homo sapiens 38-41
7527211-9 1994 CONCLUSION: E-selectin is expressed by synovial endothelium during the evolution of urate crystal-induced arthritis and can be detected noninvasively using a radiolabeled MAb. Uric Acid 84-89 E-selectin Sus scrofa 12-22
7618235-6 1995 The beta 2-microglobulin (beta 2-M) was present only in calcium oxalate and uric acid stones. Uric Acid 76-85 beta-2-microglobulin Homo sapiens 4-24
7618235-6 1995 The beta 2-microglobulin (beta 2-M) was present only in calcium oxalate and uric acid stones. Uric Acid 76-85 beta-2-microglobulin Homo sapiens 26-34
7527211-0 1994 Noninvasive imaging of E-selectin expression by activated endothelium in urate crystal-induced arthritis. Uric Acid 73-78 E-selectin Sus scrofa 23-33
7918315-6 1994 Fasting insulin concentration was significantly associated with levels of glucose, triglycerides, uric acid, serum albumin, creatinine, and fibrinogen as well as resting heart rate. Uric Acid 98-107 insulin Homo sapiens 8-15
7921432-9 1994 Ascorbate, EDTA, and uric acid reduced the proteolytic susceptibility of O3-exposed elastin, but mannitol afforded no protection. Uric Acid 21-30 elastin Homo sapiens 84-91
7809582-3 1994 By spiking normal human serum with increasing PLP concentrations from 62.5 to 1000 mumol l-1, we observed a decrease in the urate recovery from 125 mumol l-1 (-11%). Uric Acid 124-129 pyridoxal phosphatase Homo sapiens 46-49
7811225-8 1994 In other patients vasopressin is "inappropriately" elevated in those with no clinical evidence of hypovolaemia (typically characterized by low serum uric acid levels) such as in Pneumocystis carinii pneumonia and other opportunistic infections leading to SIADH. Uric Acid 149-158 arginine vasopressin Homo sapiens 18-29
7809582-4 1994 At 1000 mumol l-1 PLP, only 40% of the urate concentration was measured. Uric Acid 39-44 pyridoxal phosphatase Homo sapiens 18-21
7927548-2 1994 As compared to non pregnant women, there was a significant increase in the levels of erythrocyte malonyldialdehyde and plasma urate in normotensive pregnant women, which were further increased in women with PIH. Uric Acid 126-131 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 207-210
8034647-7 1994 Before the release of urate from the molybdenum active site, an electron is transferred at 15 s-1 from the reduced molybdenum center to one of the iron-sulfur centers of XDH. Uric Acid 22-27 xanthine dehydrogenase Homo sapiens 170-173
8067535-0 1994 Novel, reagentless, amperometric biosensor for uric acid based on a chemically modified screen-printed carbon electrode coated with cellulose acetate and uricase. Uric Acid 47-56 urate oxidase (pseudogene) Homo sapiens 154-161
7937426-3 1994 Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic and diastolic blood pressure, urea, creatinine, protein, glucose (fasting and 2 hours after 75 g oral glucose load), 2 hour insulin, triglycerides, and apolipoprotein B in men. Uric Acid 47-56 insulin Homo sapiens 242-249
7937426-3 1994 Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic and diastolic blood pressure, urea, creatinine, protein, glucose (fasting and 2 hours after 75 g oral glucose load), 2 hour insulin, triglycerides, and apolipoprotein B in men. Uric Acid 47-56 apolipoprotein B Homo sapiens 270-286
8189066-2 1994 Neutrophils produce IL-1 when stimulated by monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals. Uric Acid 44-60 interleukin 1 receptor antagonist Homo sapiens 20-24
8189066-2 1994 Neutrophils produce IL-1 when stimulated by monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals. Uric Acid 62-65 interleukin 1 receptor antagonist Homo sapiens 20-24
8179319-7 1994 Cysteine, methionine, and urate, known inhibitors of peroxynitrite-mediated oxidation, inhibited luminol-enhanced chemiluminescence, while the hydroxyl radical scavengers, mannitol and dimethylsulfoxide, and catalase did not. Uric Acid 26-31 catalase Bos taurus 208-216
8056832-0 1994 Uric acid degrading enzymes, urate oxidase and allantoinase, are associated with different subcellular organelles in frog liver and kidney. Uric Acid 0-9 urate oxidase Rattus norvegicus 29-42
8056832-1 1994 On the basis of differential and density gradient centrifugation studies, the site of the uric acid degrading enzymes, urate oxidase and allantoinase, in amphibia was previously assigned to the hepatic peroxisomes. Uric Acid 90-99 urate oxidase Rattus norvegicus 119-132
8056832-9 1994 Contrary to previous assumptions, these studies also clearly establish that urate oxidase and allantoinase, the first two enzymes involved in uric acid degradation, are localized in different subcellular organelles in frog liver and kidney. Uric Acid 142-151 urate oxidase Rattus norvegicus 76-89
8288709-4 1994 In simple linear regression analysis, the serum uric acid concentration (range, 182-568 mumol/L) was inversely correlated with insulin sensitivity (rate of glucose utilization; r = -0.61; P < 0.001) and positively with serum triglycerides (r = 0.68; P < 0.001), but not with body mass index, age, or the plasma glucose concentration. Uric Acid 48-57 insulin Homo sapiens 127-134
8205270-6 1994 (Means for cases versus controls: 16.8 and 16.6 microU/mL), although serum insulin showed significant correlations with low-density-lipoprotein cholesterol, triglycerides, and uric acid. Uric Acid 176-185 insulin Homo sapiens 75-82
8090664-4 1994 An increase in serum uric acid with a decrease in iron levels and transferrin saturation have been noted in all children. Uric Acid 21-30 transferrin Homo sapiens 66-77
8290593-1 1994 Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. Uric Acid 102-111 urate oxidase Mus musculus 0-13
8290593-1 1994 Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. Uric Acid 102-111 urate oxidase (pseudogene) Homo sapiens 18-25
8288709-5 1994 In multiple linear regression analysis, both insulin sensitivity (P < 0.05) and serum triglycerides (P < 0.005) were independently associated with the serum uric acid concentration, and together explained 50% of its variation. Uric Acid 163-172 insulin Homo sapiens 45-52
8253776-1 1993 Superactivity of phosphoribosylpyrophosphate synthetase (PRS) is an X chromosome-linked disorder of purine metabolism, characterized by gout with uric acid overproduction and, in some families, neurodevelopmental impairment. Uric Acid 146-155 PRS Homo sapiens 57-60
8015488-10 1994 Other reducing agents such as GSH and uric acid can interfere in colorimetric methods that rely on the reducing action of ASC. Uric Acid 38-47 PYD and CARD domain containing Rattus norvegicus 122-125
8309876-7 1993 Uric acid, a product of purine metabolism, was lower (P < .05) in liver and lung in ASC birds at 3 wk compared with control birds. Uric Acid 0-9 PYD and CARD domain containing Homo sapiens 87-90
8309876-8 1993 However, uric acid concentrations in ASC birds were higher (P < .05) in the lung and serum at 5 wk, and in the liver at 7 wk compared with NASC and control birds. Uric Acid 9-18 PYD and CARD domain containing Homo sapiens 37-40
8218378-4 1993 scavenging by pentoxifylline (Ptx, a methylxanthine), uric acid and thymine on the OH.-induced alterations of a protein, lysozyme. Uric Acid 54-63 lysozyme Homo sapiens 121-129
8137636-4 1993 Serum beta 2-MG level was significantly increased in patients with severe PIH, (P < 0.001) and it was positively correlated with serum uric acid. Uric Acid 138-147 beta-2-microglobulin Homo sapiens 6-15
8221687-5 1993 MMC interaction with XDH was also assessed by monitoring the ability of MMC to inhibit XDH-mediated uric acid and NADH formation. Uric Acid 100-109 xanthine dehydrogenase Homo sapiens 87-90
8221687-9 1993 Stimulation of uric acid formation and decreases in NADH formation by XDH in the presence of MMC suggest that MMC interaction with XDH may occur at the NAD(+)-binding region of the enzyme. Uric Acid 15-24 xanthine dehydrogenase Homo sapiens 131-134
8263676-3 1993 It seems the ACCB may be a good adsorbent system for the removal of toxic uric acid, creatinine, bilirubin, etc., from solutions; while larger molecules such as albumin are adsorbed less. Uric Acid 74-83 acetyl-CoA carboxylase beta Homo sapiens 13-17
8226898-7 1993 Thus, ADA is part of a purine catabolic pathway leading to the production of uric acid that is present at the highest known level in the proximal small intestine. Uric Acid 77-86 adenosine deaminase Mus musculus 6-9
8287417-10 1993 Apparent xanthine oxidoreductase was calculated as xanthine +2 x urate production. Uric Acid 65-70 xanthine dehydrogenase Homo sapiens 9-32
8392790-3 1993 Serum thrombomodulin levels correlated positively with serum creatinine (r = 0.854, p < 0.0001) and uric acid levels (r = 0.784, p < 0.001). Uric Acid 103-112 thrombomodulin Homo sapiens 6-20
8261625-9 1993 Similar variations in CSF(y) and serum(x) for urate concentrations are observed due to the strong correlation y = 0.1x +/- 10 mumol/l, including 99% of the cases with an urate serum concentration range from 80 mumol/l to 460 mumol/l. Uric Acid 46-51 colony stimulating factor 2 Homo sapiens 22-25
8261625-9 1993 Similar variations in CSF(y) and serum(x) for urate concentrations are observed due to the strong correlation y = 0.1x +/- 10 mumol/l, including 99% of the cases with an urate serum concentration range from 80 mumol/l to 460 mumol/l. Uric Acid 170-175 colony stimulating factor 2 Homo sapiens 22-25
8099493-9 1993 Furthermore, several lines of evidence indicate that metabolism of hypoxanthine to xanthine and uric acid by xanthine oxidase does not mediate the inhibitory action of this purine base on meiotic maturation. Uric Acid 96-105 xanthine dehydrogenase Mus musculus 109-125
8325534-7 1993 Intriguingly, urate prevents oxidative inactivation of endothelial enzymes (cyclooxygenase, angiotensin converting enzyme) and preserves the ability of the endothelium to mediate vascular dilatation in the face of oxidative stress, suggesting a particular relationship between the site of urate formation and the need for a biologically potent radical scavenger and antioxidant. Uric Acid 14-19 angiotensin I converting enzyme Homo sapiens 76-121
8458566-6 1993 We conclude that the lack of xanthine dehydrogenase in these mutants leads to the absence of urate, which is the proximate cause of paraquat sensitivity. Uric Acid 93-98 rosy Drosophila melanogaster 29-51
8449482-8 1993 The APOE*4 allele was significantly associated with unadjusted APO-A1 and APO-E levels but not with any other dependent variable; associations with adjusted APO-A1, APO-C2, and uric acid also approached standard levels of statistical significance (p < or = 0.05). Uric Acid 177-186 apolipoprotein E Homo sapiens 4-10
8449482-9 1993 In univariate analyses the APOA4*4 allele was significantly associated with APO-B, serum glucose, percent glycated hemoglobin, and uric acid, but no significant associations were observed after dependent variables were adjusted for age, sex, weight, and height. Uric Acid 131-140 apolipoprotein A4 Homo sapiens 27-32
1281039-2 1992 Dicumarol, which has previously been shown to inhibit xanthine oxidase (XO), inhibited both XDH and XO mediated conversion of xanthine to uric acid but potentiated the metabolism of mitomycin C by XDH and XO. Uric Acid 138-147 xanthine dehydrogenase Homo sapiens 92-95
8381009-4 1993 Cytochrome C was also studied but was found to undergo spontaneous reduction by monosodium urate (MSU) without cells. Uric Acid 80-96 cytochrome c, somatic Homo sapiens 0-12
8381009-4 1993 Cytochrome C was also studied but was found to undergo spontaneous reduction by monosodium urate (MSU) without cells. Uric Acid 98-101 cytochrome c, somatic Homo sapiens 0-12
1328233-3 1992 XDH has a turnover number for the NAD-dependent conversion of xanthine to urate of 380 mol/min/mol at pH 7.5, 25 degrees C, with a Km = < or = 1 microM for xanthine and a Km = 7 microM for NAD, but has very little O2-dependent activity. Uric Acid 74-79 xanthine dehydrogenase Homo sapiens 0-3
1362115-5 1992 From simple linear regression analysis, female gender, high BMI and elevated triglyceride and uric acid levels were correlated with insulin levels (p < 0.05). Uric Acid 94-103 insulin Homo sapiens 132-139
1431569-7 1992 Despite finding no correlation between serum apoA-IV and triglyceride levels (in either the d less than 1.006 g/ml or 1.006 less than d less than 1.019 g/ml fraction), serum apoA-IV was positively correlated with the renal function parameters of blood urea nitrogen (r = 0.949, P less than 0.001), creatinine (r = 0.952, P less than 0.001), and uric acid (r = 0.903, P less than 0.001). Uric Acid 345-354 apolipoprotein A4 Rattus norvegicus 174-181
1503884-2 1992 Interleukin-8, released from mononuclear cells that have been exposed to urate and other crystals, is a potent chemotaxin and activator of neutrophils. Uric Acid 73-78 C-X-C motif chemokine ligand 8 Homo sapiens 0-13
1398221-1 1992 The reactivity of the endogenous antioxidants ascorbate, ergothioneine, and urate toward the high oxidation state of sperm whale myoglobin, ferrylmyoglobin-formed upon oxidation of metmyoglobin by H2O2--was evaluated by optical spectroscopy and SDS-PAGE analysis. Uric Acid 76-81 myoglobin Physeter catodon 129-138
1590489-5 1992 Ovine prolactin resulted in an elevation of plasma urate concentration but had no significant effects on other plasma parameters or on the concentration of the various ions in tubular fluid samples. Uric Acid 51-56 prolactin Homo sapiens 6-15
1594592-1 1992 Urate oxidase (EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but absent in humans and hominoid primates. Uric Acid 61-70 urate oxidase Rattus norvegicus 0-13
1316606-7 1992 The ry gene is the structural gene for the molybdoenzyme, xanthine dehydrogenase; xanthine dehydrogenase-null ry mutants are therefore unable to synthesize urate. Uric Acid 156-161 rosy Drosophila melanogaster 82-104
1567195-7 1992 These data support the view that ergothioneine and urate delay oxyhemoglobin oxidation by nitrite upon the temporary removal of the propagating species, i.e., nitrogen dioxide and, secondarily, ferrylhemoglobin, and within a mechanism encompassing alterations of the nitrite in equilibrium with nitrogen dioxide and ferrylhemoglobin in equilibrium with methemoglobin redox transitions. Uric Acid 51-56 hemoglobin subunit gamma 2 Homo sapiens 353-366
1592227-2 1992 Angiotensin II (5 nM) increased perfusion pressure, O2 uptake and the release of lactate, uracil and uric acid from the perfused rat hindlimb. Uric Acid 101-110 angiotensinogen Rattus norvegicus 0-14
1576959-5 1992 Exogenous hypoxanthine and adenine, which partially inhibited development, were taken up by the embryos and converted to xanthine, most probably by salvage pathways, since the enzyme xanthine oxidase, which converts hypoxanthine directly to xanthine and then to uric acid, could not be detected. Uric Acid 262-271 xanthine dehydrogenase Mus musculus 183-199
1403344-0 1992 User-defined serum aspartate and alanine aminotransferase, cholesterol, triglycerides, urea, and uric acid for the Beckman synchron CX 4/5 using Ames Sera-Pak reagents. Uric Acid 97-106 gap junction protein gamma 1 Homo sapiens 132-138
1806295-2 1991 This method is based on an enzymatic reaction with uricase to form hydrogen peroxide from uric acid and the following oxidation of o-phenylenediamine with peroxidase and hydrogen peroxide for the production of a fluorescence compound. Uric Acid 90-99 urate oxidase (pseudogene) Homo sapiens 51-58
1820474-0 1991 Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. Uric Acid 108-117 insulin Homo sapiens 35-42
1820474-1 1991 OBJECTIVE: To define the relationship, if any, between insulin-mediated glucose disposal and serum uric acid. Uric Acid 99-108 insulin Homo sapiens 55-62
1820474-6 1991 RESULTS: Magnitude of insulin resistance and serum uric acid concentration were significantly related (r = .69; P less than .001), and the relationship persisted when differences in age, sex, overall obesity, and abdominal obesity were taken into account (r = .57; P less than .001). Uric Acid 51-60 insulin Homo sapiens 22-29
1820474-7 1991 Insulin resistance was also inversely related to urinary uric acid clearance (r = -.49; P less than .002), and, in addition, urinary uric acid clearance was inversely related to serum uric acid concentration (r = -.61; P less than .001). Uric Acid 57-66 insulin Homo sapiens 0-7
1820474-8 1991 CONCLUSIONS: Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Uric Acid 21-30 insulin Homo sapiens 91-98
1820474-8 1991 CONCLUSIONS: Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Uric Acid 164-173 insulin Homo sapiens 91-98
1665405-1 1991 The mechanisms of cyclosporine A (Cs A) nephrotoxicity are not clear, but may be associated with high blood pressure and high serum uric acid levels even when kidney function is still normal. Uric Acid 132-141 chorionic somatomammotropin hormone 1 Homo sapiens 34-38
1331894-4 1992 At 1 pmol/kg per min, Ang II decreased maximal urine flow and the fractional excretions of lithium and uric acid. Uric Acid 103-112 angiotensinogen Homo sapiens 22-28
1357814-5 1992 Xanthine oxidoreductase produces urate which is a scavenger of oxygen-derived radicals. Uric Acid 33-38 xanthine dehydrogenase Rattus norvegicus 0-23
1654817-5 1991 Uric acid and tryptophan inhibited the oxidation of ABTS, stimulation of luminol chemiluminescence, and inactivation of cytochrome c. Uric Acid 0-9 cytochrome c, somatic Homo sapiens 120-132
1793049-1 1991 Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). Uric Acid 168-171 interleukin 1 alpha Homo sapiens 89-108
1771807-9 1991 The higher blood pressure levels were associated also with other manifestations of insulin resistance, i.e. elevated triacylglycerols, low HDL cholesterol levels, raised uric acid levels. Uric Acid 170-179 insulin Homo sapiens 83-90
18965220-1 1991 The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. Uric Acid 142-151 urate oxidase (pseudogene) Homo sapiens 4-11
2059236-5 1991 In addition, an IL-8-specific antibody markedly inhibited the neutrophil-activating capacity of the conditioned media from monocytes activated by urate crystals, as well as by inflammatory silica crystals. Uric Acid 146-151 C-X-C motif chemokine ligand 8 Homo sapiens 16-20
18965220-3 1991 The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Uric Acid 56-65 urate oxidase (pseudogene) Homo sapiens 176-183
1881462-8 1991 The relation between the affinity of uricosuric drug for urate and PAH transporters corresponds well with the difference between the effect on FEurate and that on FEPAH. Uric Acid 57-62 phenylalanine hydroxylase Rattus norvegicus 67-70
2022672-0 1991 Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. Uric Acid 0-9 platelet derived growth factor subunit A Rattus norvegicus 77-115
2022672-2 1991 This enzyme, activated during ischemia/reperfusion by proteolytic conversion of xanthine dehydrogenase, catalyzes the oxidation of xanthine, thereby generating free radicals and uric acid. Uric Acid 178-187 xanthine dehydrogenase Rattus norvegicus 80-102
2022672-9 1991 Exposure of quiescent VSMC to uric acid stimulated accumulation of PDGF A-chain mRNA (greater than 5-fold at 8 h) and secretion of PDGF-like material in conditioned medium (greater than 10-fold at 24 h). Uric Acid 30-39 platelet derived growth factor subunit A Rattus norvegicus 67-73
2022672-10 1991 Uric acid-induced [3H]thymidine incorporation was markedly inhibited by incubation with anti-PDGF A-chain polyclonal antibodies. Uric Acid 0-9 platelet derived growth factor subunit A Rattus norvegicus 93-99
2022672-11 1991 Thus uric acid stimulates VSMC growth via an autocrine mechanism involving PDGF A-chain. Uric Acid 5-14 platelet derived growth factor subunit A Rattus norvegicus 75-81
2010550-0 1991 Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Uric Acid 0-5 tumor necrosis factor Homo sapiens 39-66
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 12-28 tumor necrosis factor Homo sapiens 116-137
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 12-28 tumor necrosis factor Homo sapiens 139-142
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 12-28 TNF receptor superfamily member 8 Homo sapiens 147-155
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 12-28 tumor necrosis factor Homo sapiens 189-192
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 12-28 tumor necrosis factor Homo sapiens 254-263
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 30-33 tumor necrosis factor Homo sapiens 116-137
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 30-33 tumor necrosis factor Homo sapiens 139-142
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 30-33 TNF receptor superfamily member 8 Homo sapiens 147-155
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 30-33 tumor necrosis factor Homo sapiens 189-192
2010550-2 1991 Crystals of monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited selectively by monoclonal antibody to TNF alpha. Uric Acid 30-33 tumor necrosis factor Homo sapiens 254-263
1842557-8 1991 Slight decreases in serum insulin, uric acid, and creatinine were observed after the seventh administration of IGF-I. Uric Acid 35-44 insulin like growth factor 1 Homo sapiens 111-116
2021865-1 1991 Xanthine oxidase is the pathological form of xanthine oxidoreductase, which generates free oxygen radicals, when it converts (hypo)xanthine to urate. Uric Acid 143-148 xanthine dehydrogenase Homo sapiens 45-68
1797624-3 1991 As the concentration of uric acid increases, the length of the slow phase increases until a concentration is reached at which the rate of methemoglobin formation is nearly linear until the reaction is complete. Uric Acid 24-33 hemoglobin subunit gamma 2 Homo sapiens 138-151
1797624-9 1991 At higher concentrations, the radical may undergo electron transfer with oxyhemoglobin to regenerate the uric acid and form methemoglobin. Uric Acid 105-114 hemoglobin subunit gamma 2 Homo sapiens 124-137
2065817-3 1991 Uric acid synthesis from xanthine in vitro by isolated pancreatic acinii is saturable and dependent on the activity of xanthine dehydrogenase. Uric Acid 0-9 xanthine dehydrogenase Gallus gallus 119-141
1985096-0 1991 Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Uric Acid 48-64 apolipoprotein E Homo sapiens 0-22
1985096-1 1991 Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo. Uric Acid 79-84 apolipoprotein E Homo sapiens 62-67
1985096-3 1991 Lipoproteins that bear apo B-100 and apo E bind to urate crystals and suppress crystal-neutrophil interaction. Uric Acid 51-56 apolipoprotein B Homo sapiens 23-32
1985096-3 1991 Lipoproteins that bear apo B-100 and apo E bind to urate crystals and suppress crystal-neutrophil interaction. Uric Acid 51-56 apolipoprotein E Homo sapiens 37-42
1985096-4 1991 In this study, we observed that urate crystals, coated with apo E of monocyte origin, had a diminished ability to stimulate neutrophils. Uric Acid 32-37 apolipoprotein E Homo sapiens 60-65
1985096-5 1991 Apo E was also detected on the surface of urate crystals recovered from gout patients. Uric Acid 42-47 apolipoprotein E Homo sapiens 0-5
1985096-9 1991 Apo E binds to urate crystals and could modulate gouty inflammation. Uric Acid 15-20 apolipoprotein E Homo sapiens 0-5
2162269-0 1990 Dissociation between uric acid and urea clearances in the syndrome of inappropriate secretion of antidiuretic hormone related to salt excretion. Uric Acid 21-30 arginine vasopressin Homo sapiens 97-117
2230125-0 1990 Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein. Uric Acid 0-16 phospholipase A2 group IB Homo sapiens 36-52
2230125-0 1990 Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein. Uric Acid 0-16 phospholipase A2 group IB Homo sapiens 94-110
2254894-5 1990 All 3 agents caused a concentration dependent inhibition of MSUM induced hemolysis that was not due to a decrease in MSUM binding to the pretreated membranes. Uric Acid 60-64 paired box 5 Homo sapiens 0-5
2217195-12 1990 Uricase (which degrades uric acid) metabolized both uric acid and the purified antioxidant. Uric Acid 24-33 urate oxidase (pseudogene) Homo sapiens 0-7
2217195-12 1990 Uricase (which degrades uric acid) metabolized both uric acid and the purified antioxidant. Uric Acid 52-61 urate oxidase (pseudogene) Homo sapiens 0-7
2258861-6 1990 Dividing the hypertensives according to Na-K cotransport value, the high Na-K cotransport subgroup has lower fractional percent excretion of uric acid and plasma renin activity. Uric Acid 141-150 TANK binding kinase 1 Homo sapiens 40-44
2258861-6 1990 Dividing the hypertensives according to Na-K cotransport value, the high Na-K cotransport subgroup has lower fractional percent excretion of uric acid and plasma renin activity. Uric Acid 141-150 TANK binding kinase 1 Homo sapiens 73-77
2258861-7 1990 These data suggest that the high Na-K cotransport subgroup has peculiar characteristics of greater proximal tubular reabsorption (lower fractional excretion of uric acid) that may cause body volume expansion (lower plasma renin activity). Uric Acid 160-169 TANK binding kinase 1 Homo sapiens 33-37
2162269-7 1990 In the syndrome of inappropriate secretion of antidiuretic hormone, the fractional excretion of filtered urea was inversely correlated to the fractional excretion of filtered sodium (r = -0.66; P less than 0.001), whereas the fractional excretion of filtered uric acid was not dependent on sodium excretion. Uric Acid 259-268 arginine vasopressin Homo sapiens 46-66
2181784-3 1990 A recent modification of the Nitroblue Tetrazolium (NBT) reagent, improved by addition of tensides and uricase, exhibits lower interference by lipaemia and urate. Uric Acid 156-161 urate oxidase (pseudogene) Homo sapiens 103-110
2325827-5 1990 The chemiluminescent reaction is based on the conversion of adenosine into uric acid and H2O2 by adenosine deaminase, nucleoside phosphorylase, and xanthine oxidase enzymes. Uric Acid 75-84 adenosine deaminase Homo sapiens 97-116
33798500-3 2021 Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Uric Acid 6-11 solute carrier family 2 member 9 Homo sapiens 83-88
33798500-3 2021 Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Uric Acid 6-11 solute carrier family 2 member 9 Homo sapiens 90-96
33798500-3 2021 Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Uric Acid 6-11 solute carrier family 22 member 12 Homo sapiens 99-104
33798500-3 2021 Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Uric Acid 6-11 solute carrier family 22 member 12 Homo sapiens 106-114
33798500-3 2021 Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Uric Acid 6-11 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 121-126
33798500-4 2021 Activation of the NLRP3 inflammasome by monosodium urate crystals with release of IL-1beta plays a major role in the initiation of the gout flare; aggregated neutrophil extracellular traps are important in the resolution phase. Uric Acid 40-56 NLR family pyrin domain containing 3 Homo sapiens 18-23
33801813-2 2021 Since ABCG2 plays a pivotal role in uric acid clearance, its malfunction may lead to hyperuricemia and gout. Uric Acid 36-45 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 6-11
33795813-2 2021 This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions independent of xanthine oxidoreductase (XOR), which is involved in uric acid and ROS production. Uric Acid 190-199 xanthine dehydrogenase Homo sapiens 138-161
33795813-2 2021 This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions independent of xanthine oxidoreductase (XOR), which is involved in uric acid and ROS production. Uric Acid 190-199 xanthine dehydrogenase Homo sapiens 163-166
33768618-3 2021 The aim of this study was to investigate the effect of trehalose and select antioxidants (uric acid, butylated hydroxytoluene, and l-ascorbic acid) on oxytocin stability in solution. Uric Acid 90-99 oxytocin/neurophysin I prepropeptide Homo sapiens 151-159
33811534-10 2021 Moreover, within DN group, the concentration of serum CN-1 was positively correlated with uric acid (UA, r = 0.376, p = 0.026) and serum creatinine (SCr, r = 0.399, p = 0.018) and negatively correlated with serum albumin (Alb, r = - 0.348, p = 0.041) and estimated glomerular filtration rate (eGRF, r = - 0.432, p = 0.010). Uric Acid 90-99 carnosine dipeptidase 1 Homo sapiens 54-58
33770169-0 2021 Genetic Predisposition to Type 2 Diabetes and Insulin Levels is Positively Associated with Serum Urate Levels. Uric Acid 97-102 insulin Homo sapiens 46-53
33770169-7 2021 RESULTS: Genetic predisposition to higher risk of T2D (beta=0.042; 95% CI=0.016-0.068; p=0.002) and higher levels of fasting insulin (beta=0.756; 95% CI=0.408-1.102; p=1.96e-05) were significantly associated with increased serum urate concentrations. Uric Acid 229-234 insulin Homo sapiens 125-132
33770169-10 2021 CONCLUSIONS: This study provides supportive evidence on causal associations of T2D and fasting insulin with serum urate concentrations, and suggestive association of fasting insulin with risk of gout. Uric Acid 114-119 insulin Homo sapiens 95-102
33767379-1 2022 Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. Uric Acid 107-116 solute carrier family 22 member 12 Homo sapiens 0-19
33767379-1 2022 Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. Uric Acid 107-116 solute carrier family 22 member 12 Homo sapiens 21-26
33767379-1 2022 Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. Uric Acid 107-116 solute carrier family 2 member 9 Homo sapiens 32-53
33767379-1 2022 Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. Uric Acid 107-116 solute carrier family 2 member 9 Homo sapiens 55-60
33767379-4 2022 We showed that CDER167 exerted dual-target inhibitory effects on both URAT1 and GLUT9: CDER167 concentration-dependently inhibited the uptake of [14C]-uric acid in URAT1-expressing HEK293 cells with an IC50 value of 2.08 +- 0.31 muM, which was similar to that of RDEA3170 (its IC50 value was 1.47 +- 0.23 muM). Uric Acid 151-160 solute carrier family 22 member 12 Homo sapiens 70-75
33767379-4 2022 We showed that CDER167 exerted dual-target inhibitory effects on both URAT1 and GLUT9: CDER167 concentration-dependently inhibited the uptake of [14C]-uric acid in URAT1-expressing HEK293 cells with an IC50 value of 2.08 +- 0.31 muM, which was similar to that of RDEA3170 (its IC50 value was 1.47 +- 0.23 muM). Uric Acid 151-160 solute carrier family 2 member 9 Homo sapiens 80-85
33767379-4 2022 We showed that CDER167 exerted dual-target inhibitory effects on both URAT1 and GLUT9: CDER167 concentration-dependently inhibited the uptake of [14C]-uric acid in URAT1-expressing HEK293 cells with an IC50 value of 2.08 +- 0.31 muM, which was similar to that of RDEA3170 (its IC50 value was 1.47 +- 0.23 muM). Uric Acid 151-160 solute carrier family 22 member 12 Homo sapiens 164-169
33815743-7 2021 However, compared with the non-SGLT2-I group, the SGLT2-I group showed a significant decrease in body weight (p < 0.001), alanine aminotransferase (p = 0.02), uric acid (p < 0.001), and Fibrosis-4 (FIB-4) index (p = 0.01) at week 48. Uric Acid 159-168 solute carrier family 5 member 2 Homo sapiens 50-55
8806924-5 1996 In lungs injected with TNF-alpha, SNAP had no effect on Ppc and increased delta W. The peroxynitrite (ONOO-) scavenger urate (35 mM) prevented the TNF-alpha +SNAP-induced increases in Ppc and delta W. In addition, chemically synthesized ONOO- (4.0 mM) enhanced U-46619-induced increases in delta W. The data indicate that nitric oxide repletion enhances TNF-alpha-induced pulmonary edema, possibly via ONOO-. Uric Acid 119-124 tumor necrosis factor Cavia porcellus 23-32
25646371-0 2015 Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. Uric Acid 69-85 microRNA 146a Homo sapiens 8-16
8806924-5 1996 In lungs injected with TNF-alpha, SNAP had no effect on Ppc and increased delta W. The peroxynitrite (ONOO-) scavenger urate (35 mM) prevented the TNF-alpha +SNAP-induced increases in Ppc and delta W. In addition, chemically synthesized ONOO- (4.0 mM) enhanced U-46619-induced increases in delta W. The data indicate that nitric oxide repletion enhances TNF-alpha-induced pulmonary edema, possibly via ONOO-. Uric Acid 119-124 tumor necrosis factor Cavia porcellus 147-156
8806924-5 1996 In lungs injected with TNF-alpha, SNAP had no effect on Ppc and increased delta W. The peroxynitrite (ONOO-) scavenger urate (35 mM) prevented the TNF-alpha +SNAP-induced increases in Ppc and delta W. In addition, chemically synthesized ONOO- (4.0 mM) enhanced U-46619-induced increases in delta W. The data indicate that nitric oxide repletion enhances TNF-alpha-induced pulmonary edema, possibly via ONOO-. Uric Acid 119-124 tumor necrosis factor Cavia porcellus 147-156
34935515-6 2022 Silencing CXCL-13 reversed uric-acid-induced lipid droplet accumulation, which further downregulated FAS and SREBP1 expression, inhibited the p38 and PKC signaling, and activated AMPK signaling. Uric Acid 27-36 chemokine (C-X-C motif) ligand 13 Mus musculus 10-17
34935515-6 2022 Silencing CXCL-13 reversed uric-acid-induced lipid droplet accumulation, which further downregulated FAS and SREBP1 expression, inhibited the p38 and PKC signaling, and activated AMPK signaling. Uric Acid 27-36 sterol regulatory element binding transcription factor 1 Mus musculus 109-115
34935515-6 2022 Silencing CXCL-13 reversed uric-acid-induced lipid droplet accumulation, which further downregulated FAS and SREBP1 expression, inhibited the p38 and PKC signaling, and activated AMPK signaling. Uric Acid 27-36 mitogen-activated protein kinase 14 Mus musculus 142-145
34784237-2 2022 Our previous study demonstrated that paeonol suppressed IL-1beta production in rats with monosodium urate (MSU)-induced arthritis. Uric Acid 89-105 interleukin 1 alpha Rattus norvegicus 56-64
34085179-17 2022 In summary, our findings revealed that upregulation of miR-296-3p protected pancreatic beta-cells functions against UA-induced dysfunction by targeting PTEN, which provides a novel agent for type 2 diabetes treatment. Uric Acid 116-118 phosphatase and tensin homolog Mus musculus 152-156
34085179-15 2022 UA treatment prominently decreased cell viability, promoted apoptotic cells, enhanced Bax levels, declined Bcl-2 level as well as decreased insulin release in Min6 cells. Uric Acid 0-2 BCL2-associated X protein Mus musculus 86-89
34085179-15 2022 UA treatment prominently decreased cell viability, promoted apoptotic cells, enhanced Bax levels, declined Bcl-2 level as well as decreased insulin release in Min6 cells. Uric Acid 0-2 B cell leukemia/lymphoma 2 Mus musculus 107-112
34085179-16 2022 MiR-296-3p mimic significantly alleviated UA-induced pancreatic beta-cells dysfunction, and PTEN-plasmid eliminated the protective effect of miR-296-3p on insulin release, cell viability, and apoptosis of pancreatic beta-cells in UA-stimulated Min6 cells. Uric Acid 230-232 phosphatase and tensin homolog Mus musculus 92-96
34784237-5 2022 In J774A.1 cells induced by LPS plus MSU, paeonol decreased the levels of IL-1beta and caspase-1 and reduced the MSU-induced interaction of pro-caspase-1 and apoptosis-associated speck-like protein containing caspase recruitment domain (ASC), but did not affect the levels of pro-IL-1beta and pro-caspase-1. Uric Acid 113-116 caspase 1 Mus musculus 144-153
34784237-2 2022 Our previous study demonstrated that paeonol suppressed IL-1beta production in rats with monosodium urate (MSU)-induced arthritis. Uric Acid 107-110 interleukin 1 alpha Rattus norvegicus 56-64
34784237-5 2022 In J774A.1 cells induced by LPS plus MSU, paeonol decreased the levels of IL-1beta and caspase-1 and reduced the MSU-induced interaction of pro-caspase-1 and apoptosis-associated speck-like protein containing caspase recruitment domain (ASC), but did not affect the levels of pro-IL-1beta and pro-caspase-1. Uric Acid 113-116 PYD and CARD domain containing Mus musculus 237-240
34848368-0 2022 Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. Uric Acid 33-42 thioredoxin interacting protein Homo sapiens 10-15
34954337-0 2022 Enterocyte synthesizes and secrets uric acid as antioxidant to protect against oxidative stress via the involvement of Nrf pathway. Uric Acid 35-44 NFKB repressing factor Homo sapiens 119-122
34954337-5 2022 The regulation of Nrf2 pathway on UA secretion and transport were evaluated in the present of agonist (TBHQ) and inhibitor (ML385) of Nrf2. Uric Acid 34-36 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22
34954337-10 2022 UA attenuated H2O2-induced oxidative damage by Nrf2 pathway. Uric Acid 0-2 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51
34954337-11 2022 UA secretion and transport were reduced by blocking Nrf2 with ML385, while increased by activating Nrf2 with TBHQ. Uric Acid 0-2 NFE2 like bZIP transcription factor 2 Homo sapiens 52-56
34954337-11 2022 UA secretion and transport were reduced by blocking Nrf2 with ML385, while increased by activating Nrf2 with TBHQ. Uric Acid 0-2 NFE2 like bZIP transcription factor 2 Homo sapiens 99-103
34972043-7 2022 MSU induced an increase in IFN-gamma and IL-22 in all studied groups. Uric Acid 0-3 interferon gamma Homo sapiens 27-36
34972043-7 2022 MSU induced an increase in IFN-gamma and IL-22 in all studied groups. Uric Acid 0-3 interleukin 22 Homo sapiens 41-46
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 98-107 urate oxidase Rattus norvegicus 176-183
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 98-107 catalase Rattus norvegicus 188-196
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 98-107 catalase Rattus norvegicus 198-201
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 98-107 catalase Rattus norvegicus 203-206
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 109-111 urate oxidase Rattus norvegicus 176-183
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 109-111 catalase Rattus norvegicus 188-196
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 109-111 catalase Rattus norvegicus 198-201
34968071-2 2022 To tackle this limitation, previous studies adopted a cascade reaction between the degradation of uric acid (UA) and timely elimination of H2O2 using complicated composites of uricase and catalase (CAT)/CAT-like nanozyme. Uric Acid 109-111 catalase Rattus norvegicus 203-206
34968071-3 2022 Herein, the self-cascade nanozyme Pt/CeO2 with high efficiency toward simultaneous UA degradation and H2O2 elimination is demonstrated on the basis of both uricase- and CAT-like activities in Pt, Ir, Rh, and Pd platinum-group metals. Uric Acid 83-85 urate oxidase Rattus norvegicus 156-163
34968071-3 2022 Herein, the self-cascade nanozyme Pt/CeO2 with high efficiency toward simultaneous UA degradation and H2O2 elimination is demonstrated on the basis of both uricase- and CAT-like activities in Pt, Ir, Rh, and Pd platinum-group metals. Uric Acid 83-85 catalase Rattus norvegicus 169-172
34617381-0 2022 Effects of SGLT-2 inhibitors on serum uric acid in patients with T2DM: A systematic review and network meta-analysis. Uric Acid 38-47 solute carrier family 5 member 2 Homo sapiens 11-17
34617381-1 2022 AIMS: The present study aims to determine the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors on the serum uric acid (SUA) levels of patients with type 2 diabetes mellitus (T2DM) in Asia. Uric Acid 121-130 solute carrier family 5 member 2 Homo sapiens 57-87
34617381-1 2022 AIMS: The present study aims to determine the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors on the serum uric acid (SUA) levels of patients with type 2 diabetes mellitus (T2DM) in Asia. Uric Acid 121-130 solute carrier family 5 member 2 Homo sapiens 89-95
34875574-0 2022 Human fetal membrane IL-1beta production in response to bacterial components is mediated by uric-acid induced NLRP3 inflammasome activation. Uric Acid 92-101 NLR family pyrin domain containing 3 Homo sapiens 110-115
34875574-11 2022 FM IL-1beta secretion was inhibited by allopurinol, which blocks uric acid production, for LPS and PGN, and to a lesser degree, MDP. Uric Acid 65-74 interleukin 1 alpha Homo sapiens 3-11
34921301-7 2022 In the meantime, highly pleiotropic CMR and urate-lowering benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors and key lifestyle measures could play an important role in comorbidity care, in conjunction with effective gout care based on target serum urate concentrations according to the latest guidelines. Uric Acid 44-49 solute carrier family 5 member 2 Homo sapiens 71-101
34921301-7 2022 In the meantime, highly pleiotropic CMR and urate-lowering benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors and key lifestyle measures could play an important role in comorbidity care, in conjunction with effective gout care based on target serum urate concentrations according to the latest guidelines. Uric Acid 44-49 solute carrier family 5 member 2 Homo sapiens 103-108
34619319-0 2022 Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-kappaB and NLRP3 inflammasome. Uric Acid 42-58 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 112-121
34619319-0 2022 Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-kappaB and NLRP3 inflammasome. Uric Acid 42-58 NLR family, pyrin domain containing 3 Mus musculus 126-131
34601891-0 2022 CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats. Uric Acid 23-32 C1q and TNF related 3 Homo sapiens 0-5
34601891-2 2022 This study was designed to investigate whether C1q/tumor necrosis factor (TNF)-related protein 3 (CTRP3) has a protective effect on endothelial damage induced by uric acid and its underlying mechanisms. Uric Acid 162-171 C1q and TNF related 3 Homo sapiens 98-103
34601891-10 2022 Similarly, CTRP3 overexpression decreased TLR4-mediated inflammation, reduced oxidative stress, and rescued endothelial damage induced by uric acid in HUVECs. Uric Acid 138-147 C1q and TNF related 3 Homo sapiens 11-16
34601891-11 2022 In conclusion, CTRP3 ameliorates uric acid-induced inflammation and oxidative stress, which in turn protects against endothelial injury, possibly by inhibiting TLR4-mediated inflammation and downregulating oxidative stress. Uric Acid 33-42 C1q and TNF related 3 Homo sapiens 15-20
34601891-11 2022 In conclusion, CTRP3 ameliorates uric acid-induced inflammation and oxidative stress, which in turn protects against endothelial injury, possibly by inhibiting TLR4-mediated inflammation and downregulating oxidative stress. Uric Acid 33-42 toll-like receptor 4 Rattus norvegicus 160-164
34848368-0 2022 Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. Uric Acid 33-42 insulin Homo sapiens 51-58
34850960-0 2022 FGF21 attenuates high uric acid-induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1. Uric Acid 22-31 fibroblast growth factor 21 Homo sapiens 0-5
34586567-0 2022 Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU. Uric Acid 104-107 NLR family, pyrin domain containing 3 Mus musculus 44-49
34586567-7 2022 And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS. Uric Acid 177-180 NLR family, pyrin domain containing 3 Mus musculus 28-55
34586567-7 2022 And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS. Uric Acid 177-180 NLR family, pyrin domain containing 3 Mus musculus 57-62
34586567-7 2022 And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS. Uric Acid 177-180 caspase 1 Mus musculus 156-165
34586567-10 2022 Consistently, the results proved that GPS could inhibit the activation of NLRP3 inflammasome in RAW264.7 macrophages stimulated by LPS-MSU. Uric Acid 135-138 NLR family, pyrin domain containing 3 Mus musculus 74-79
34800514-0 2022 Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways. Uric Acid 84-93 angiotensin converting enzyme 2 Homo sapiens 14-18
34850960-0 2022 FGF21 attenuates high uric acid-induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1. Uric Acid 22-31 sirtuin 1 Homo sapiens 139-144
34850960-3 2022 In addition, it has been reported that fibroblast growth factor 21 (FGF21) can exert regulatory effects on UA-induced lipid accumulation. Uric Acid 107-109 fibroblast growth factor 21 Homo sapiens 39-66
34850960-3 2022 In addition, it has been reported that fibroblast growth factor 21 (FGF21) can exert regulatory effects on UA-induced lipid accumulation. Uric Acid 107-109 fibroblast growth factor 21 Homo sapiens 68-73
34850960-4 2022 Therefore, the present study aimed to investigate the possible role of FGF21 in HUVEC cell injury induced by UA. Uric Acid 109-111 fibroblast growth factor 21 Homo sapiens 71-76
34850960-9 2022 The results demonstrated that overexpression of FGF21 significantly inhibited UA treatment-induced endoplasmic reticulum (ER) stress, inflammation and oxidative stress in HUVECs. Uric Acid 78-80 fibroblast growth factor 21 Homo sapiens 48-53
34913811-5 2021 Meanwhile, Occludin, ZO-1, and RAGE protein levels were measured by western blotting; Results: Uric acid reduced the negative effects of Abeta on the vascular endothelium and smooth muscle cells and protected the vascular wall in vitro. Uric Acid 95-104 occludin Mus musculus 11-19
34313822-4 2022 High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). Uric Acid 5-7 insulin Homo sapiens 32-39
34313822-4 2022 High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). Uric Acid 5-7 insulin Homo sapiens 110-117
34313822-5 2022 At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway. Uric Acid 37-39 AKT serine/threonine kinase 1 Homo sapiens 160-163
34313822-5 2022 At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway. Uric Acid 37-39 insulin Homo sapiens 172-179
34313822-6 2022 At the distal level, high UA concentrations impair endothelial NO synthase (eNOS)-NO system by decreasing eNOS expression and activity as well as by direct inactivation of NO. Uric Acid 26-28 nitric oxide synthase 3 Homo sapiens 76-80
34313822-6 2022 At the distal level, high UA concentrations impair endothelial NO synthase (eNOS)-NO system by decreasing eNOS expression and activity as well as by direct inactivation of NO. Uric Acid 26-28 nitric oxide synthase 3 Homo sapiens 106-110
34313822-7 2022 Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. Uric Acid 12-14 insulin Homo sapiens 35-42
34313822-7 2022 Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. Uric Acid 12-14 insulin Homo sapiens 172-179
34913811-5 2021 Meanwhile, Occludin, ZO-1, and RAGE protein levels were measured by western blotting; Results: Uric acid reduced the negative effects of Abeta on the vascular endothelium and smooth muscle cells and protected the vascular wall in vitro. Uric Acid 95-104 tight junction protein 1 Mus musculus 21-25
34913811-5 2021 Meanwhile, Occludin, ZO-1, and RAGE protein levels were measured by western blotting; Results: Uric acid reduced the negative effects of Abeta on the vascular endothelium and smooth muscle cells and protected the vascular wall in vitro. Uric Acid 95-104 advanced glycosylation end product-specific receptor Mus musculus 31-35
34913811-5 2021 Meanwhile, Occludin, ZO-1, and RAGE protein levels were measured by western blotting; Results: Uric acid reduced the negative effects of Abeta on the vascular endothelium and smooth muscle cells and protected the vascular wall in vitro. Uric Acid 95-104 amyloid beta (A4) precursor protein Mus musculus 137-142
34913811-8 2021 After uric acid concentration was lowered in APP23 mice, ZO-1 and occludin expression levels were significantly lower than those in untreated animals; Conclusions: Uric acid in the blood protects the blood vessels from CAA damage to the blood vessel wall, and reduces the occurrence of cerebral hemorrhage. Uric Acid 164-173 tight junction protein 1 Mus musculus 57-61
34913811-8 2021 After uric acid concentration was lowered in APP23 mice, ZO-1 and occludin expression levels were significantly lower than those in untreated animals; Conclusions: Uric acid in the blood protects the blood vessels from CAA damage to the blood vessel wall, and reduces the occurrence of cerebral hemorrhage. Uric Acid 164-173 occludin Mus musculus 66-74
34889064-8 2022 FABP4 concentration was independently associated with FLI after adjustment of age, sex, SBP and levels of urate, HDL-C, HOMA-R, adiponectin and FGF21 in multivariable regression analysis. Uric Acid 106-111 fatty acid binding protein 4 Homo sapiens 0-5
34897641-1 2021 BACKGROUND: The data on the association between serum uric acid (sUA) concentration and outcomes in patients with an ACS are inconsistent and do not focus on patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). Uric Acid 54-63 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 117-120
34903856-7 2021 At the same time, GPC-4 levels correlated negatively with estimated glomerular filtration rate (eGFR), serum protein and serum albumin levels and were positively related to creatinine and uric acid levels at GW 35-37. Uric Acid 188-197 glypican 4 Homo sapiens 18-23
34806108-0 2021 Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice. Uric Acid 80-89 xanthine dehydrogenase Mus musculus 18-34
34806108-1 2021 Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, which is involved in the production of uric acid (UA). Uric Acid 129-138 xanthine dehydrogenase Mus musculus 57-73
34806108-1 2021 Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, which is involved in the production of uric acid (UA). Uric Acid 140-142 xanthine dehydrogenase Mus musculus 57-73
34889064-9 2022 Logistic regression analysis showed that FABP4 was an independent predictor of MAFLD after adjustment of age, sex, presence of diabetes mellitus, hypertension and dyslipidemia, and levels of urate, HOMA-R, adiponectin and FGF21. Uric Acid 191-196 fatty acid binding protein 4 Homo sapiens 41-46
34934798-2 2021 Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Abeta)42, Abeta40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Abeta42/Abeta40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. Uric Acid 52-57 amyloid beta precursor protein Homo sapiens 110-132
34887389-4 2021 At SLC2A9, the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Uric Acid 21-26 solute carrier family 2 member 9 Homo sapiens 3-9
34887389-4 2021 At SLC2A9, the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Uric Acid 21-26 solute carrier family 2 member 9 Homo sapiens 130-136
34887389-5 2021 Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. Uric Acid 61-66 solute carrier family 2 member 9 Homo sapiens 13-19
34887389-5 2021 Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. Uric Acid 134-139 solute carrier family 2 member 9 Homo sapiens 13-19
34887389-6 2021 In other genes, including SLC7A11 and PHGDH, 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. Uric Acid 48-53 solute carrier family 7 member 11 Homo sapiens 26-33
34887389-6 2021 In other genes, including SLC7A11 and PHGDH, 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. Uric Acid 48-53 phosphoglycerate dehydrogenase Homo sapiens 38-43
34944661-1 2021 Renal hypouricemia (RHUC) is a hereditary disease that presents with increased renal urate clearance and hypouricemia due to genetic mutations in the urate transporter URAT1 or GLUT9 that reabsorbs urates in the renal proximal tubule. Uric Acid 198-204 solute carrier family 22 member 12 Homo sapiens 168-173
34944661-1 2021 Renal hypouricemia (RHUC) is a hereditary disease that presents with increased renal urate clearance and hypouricemia due to genetic mutations in the urate transporter URAT1 or GLUT9 that reabsorbs urates in the renal proximal tubule. Uric Acid 198-204 solute carrier family 2 member 9 Homo sapiens 177-182
34571571-6 2021 RESULTS: A strong negative correlation proved between serum levels of AAT and all study variables except fetal weight (systolic BP, diastolic BP, MPV, PDW, serum uric acid, fetal weight percentile, and AFI) with a correlation coefficient of; -0.95, -0.95, -0.85, -0.93, -0.91, -0.94, and -0.93 respectively. Uric Acid 162-171 serpin family A member 1 Homo sapiens 70-73
34637964-0 2021 CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages. Uric Acid 19-35 CD38 molecule Homo sapiens 0-4
34663597-5 2021 TRPV4 was functionally expressed by synovial macrophages and human PBMCs and TRPV4 expression was upregulated by stimulation with monosodium urate (MSU) crystals and in human PBMCs from patients with acute gout flares. Uric Acid 130-146 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5
34663597-5 2021 TRPV4 was functionally expressed by synovial macrophages and human PBMCs and TRPV4 expression was upregulated by stimulation with monosodium urate (MSU) crystals and in human PBMCs from patients with acute gout flares. Uric Acid 130-146 transient receptor potential cation channel subfamily V member 4 Homo sapiens 77-82
34663597-5 2021 TRPV4 was functionally expressed by synovial macrophages and human PBMCs and TRPV4 expression was upregulated by stimulation with monosodium urate (MSU) crystals and in human PBMCs from patients with acute gout flares. Uric Acid 148-151 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5
34663597-5 2021 TRPV4 was functionally expressed by synovial macrophages and human PBMCs and TRPV4 expression was upregulated by stimulation with monosodium urate (MSU) crystals and in human PBMCs from patients with acute gout flares. Uric Acid 148-151 transient receptor potential cation channel subfamily V member 4 Homo sapiens 77-82
34663597-6 2021 MSU crystal-induced gouty arthritis were significantly reduced by either genetic ablation or pharmacological inhibition of TRPV4 function. Uric Acid 0-3 transient receptor potential cation channel subfamily V member 4 Homo sapiens 123-128
34663597-10 2021 TRPV4-expressing resident macrophages are critically involved in MSU crystal-induced gouty arthritis. Uric Acid 65-68 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5
34310895-5 2021 These were accompanied by reduced adenosine deaminase/xanthine oxidase/uric acid (ADA/XO/UA) pathway, lipid peroxidation and augmented NO and Na/K-ATPase in estrogen-progestin OC-treated rats.DPP-4 inhibition attenuated cardiac lipid deposition accompanied by reduced activity in the ADA/XO/UA pathway in estrogen-progestin OC-treated female rats. Uric Acid 71-80 dipeptidylpeptidase 4 Rattus norvegicus 192-197
34091747-12 2021 In the NF1 group, tubular phosphorus reabsorption was significantly lower and uric acid excretion significantly higher than in the control group.Conclusion: Hypertension, urinary tract anomalies, and impaired renal function were more common in NF1 patients than healthy controls. Uric Acid 78-87 neurofibromin 1 Homo sapiens 7-10
34091747-12 2021 In the NF1 group, tubular phosphorus reabsorption was significantly lower and uric acid excretion significantly higher than in the control group.Conclusion: Hypertension, urinary tract anomalies, and impaired renal function were more common in NF1 patients than healthy controls. Uric Acid 78-87 neurofibromin 1 Homo sapiens 244-247
34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 20-36 NLR family pyrin domain containing 3 Homo sapiens 59-64
34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 20-36 interleukin 1 alpha Homo sapiens 101-109
34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 38-41 NLR family pyrin domain containing 3 Homo sapiens 59-64
34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 38-41 interleukin 1 alpha Homo sapiens 101-109
34925366-4 2021 Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares. Uric Acid 40-43 interleukin 1 alpha Homo sapiens 194-202
34856980-8 2021 There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Uric Acid 240-249 pentraxin 3 Homo sapiens 41-45
34925239-0 2021 Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. Uric Acid 55-64 insulin Homo sapiens 16-23
34925239-1 2021 Objective: This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents. Uric Acid 54-63 insulin Homo sapiens 115-122
34862457-7 2021 Uric acid induced growth restriction and placental inflammation, which IL-1Ra protected against. Uric Acid 0-9 interleukin 1 receptor antagonist Homo sapiens 71-77
34855903-3 2021 The ABCG2 protein is a multispecific xeno- and endobiotic transporter, affecting drug metabolism and playing a key role in uric acid extrusion. Uric Acid 123-132 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 4-9
34855903-5 2021 Several other diseases, including hypertension, chronic renal failure, and T2DM have also been reported to be associated with high serum uric acid levels, suggesting that ABCG2 may also play a role in these conditions. Uric Acid 137-146 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 171-176
34874227-8 2021 SNHG8 expression was identified to be upregulated after MSU treatment. Uric Acid 56-59 small nucleolar RNA host gene 8 Mus musculus 0-5
34874227-9 2021 Ablation of SNHG8 decreased the MSU-induced enhancement of paw swelling and foot thickness. Uric Acid 32-35 small nucleolar RNA host gene 8 Mus musculus 12-17
34128490-7 2021 CONCLUSIONS: Thiazide-induced changes in serum uric acid or incident hyperuricemia were associated with the achieved SBP/DBP, being lower at the level of 130-139/<90 mm Hg. Uric Acid 47-56 selenium binding protein 1 Homo sapiens 117-120
34128490-7 2021 CONCLUSIONS: Thiazide-induced changes in serum uric acid or incident hyperuricemia were associated with the achieved SBP/DBP, being lower at the level of 130-139/<90 mm Hg. Uric Acid 47-56 D-box binding PAR bZIP transcription factor Homo sapiens 121-124
34328574-1 2021 BACKGROUND: Dotinurad is a selective urate reabsorption inhibitor (SURI), which selectively inhibits URAT1 to lower serum uric acid levels in patients with hyperuricemia. Uric Acid 37-42 solute carrier family 22 member 12 Homo sapiens 101-106
34328574-1 2021 BACKGROUND: Dotinurad is a selective urate reabsorption inhibitor (SURI), which selectively inhibits URAT1 to lower serum uric acid levels in patients with hyperuricemia. Uric Acid 122-131 solute carrier family 22 member 12 Homo sapiens 101-106
34716863-6 2021 UA uptake was concentration- and time-dependent, and UA treatment significantly reduced nitric oxide (NO) levels and eNOS activity. Uric Acid 0-2 nitric oxide synthase 3 Homo sapiens 117-121
34716863-6 2021 UA uptake was concentration- and time-dependent, and UA treatment significantly reduced nitric oxide (NO) levels and eNOS activity. Uric Acid 53-55 nitric oxide synthase 3 Homo sapiens 117-121
34716863-8 2021 GLUT9 knockdown reduced UA uptake and ROS content, but antioxidant treatment did not reduce GLUT9 expression. Uric Acid 24-26 solute carrier family 2 member 9 Homo sapiens 0-5
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 Janus kinase 2 Homo sapiens 26-30
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 signal transducer and activator of transcription 3 Homo sapiens 31-36
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 Janus kinase 2 Homo sapiens 111-115
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 signal transducer and activator of transcription 3 Homo sapiens 117-122
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 interleukin 6 Homo sapiens 124-128
34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 suppressor of cytokine signaling 3 Homo sapiens 133-138
34716863-11 2021 CONCLUSIONS: GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs. Uric Acid 48-50 solute carrier family 2 member 9 Homo sapiens 13-18
34716863-11 2021 CONCLUSIONS: GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs. Uric Acid 48-50 Janus kinase 2 Homo sapiens 120-124
34716863-11 2021 CONCLUSIONS: GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs. Uric Acid 48-50 nitric oxide synthase 3 Homo sapiens 179-183
34716863-11 2021 CONCLUSIONS: GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs. Uric Acid 105-107 solute carrier family 2 member 9 Homo sapiens 13-18
34917427-17 2021 Both IL-22 and 1,25(OH) 2 VD3 functioned in GA-related immune and inflammatory responses, and closely correlated with the level of GA-related uric acid. Uric Acid 142-151 interleukin 22 Homo sapiens 5-10
34917427-14 2021 Importantly, VD-R and IL22 closely correlated with the level of key metabolites uric acid, whose increase promoted the occurrence of GA. Uric Acid 80-89 vitamin D receptor Homo sapiens 13-17
34715618-4 2021 In the current study, a significant reduction in miR-192-5p and an increase in epiregulin (EREG) were observed in serum of GA patients, suggesting that miR-192-5p and EREG were involved in the pathogenic process of GA. A mouse GA model was established via 0.5 mg/20 muL MSU crystal administration. Uric Acid 270-273 microRNA 192 Homo sapiens 49-56
34917427-14 2021 Importantly, VD-R and IL22 closely correlated with the level of key metabolites uric acid, whose increase promoted the occurrence of GA. Uric Acid 80-89 interleukin 22 Homo sapiens 22-26
34715618-6 2021 We found that miR-192-5p overexpression induced by miR-192-5p agomir reduced EREG expression, attenuated ankle joint swelling and synovial inflammatory cell infiltration and improved bone erosion in MSU-induced GA mice. Uric Acid 199-202 microRNA 192 Mus musculus 51-58
34715618-4 2021 In the current study, a significant reduction in miR-192-5p and an increase in epiregulin (EREG) were observed in serum of GA patients, suggesting that miR-192-5p and EREG were involved in the pathogenic process of GA. A mouse GA model was established via 0.5 mg/20 muL MSU crystal administration. Uric Acid 270-273 epiregulin Homo sapiens 79-89
34844041-7 2021 The inhibition of XOR activity appears more promising than just the control of uricemia level in preventing cardiovascular events, possibly because it also reduces the intracellular accumulation of urate, as well as the production of reactive oxygen species. Uric Acid 198-203 xanthine dehydrogenase Homo sapiens 18-21
34847885-0 2021 Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction. Uric Acid 35-44 component of oligomeric golgi complex 2 Homo sapiens 64-69
34847885-1 2021 BACKGROUND: Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. Uric Acid 55-64 component of oligomeric golgi complex 2 Homo sapiens 128-133
34884248-1 2021 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role in generating oxidative stress. Uric Acid 61-70 xanthine dehydrogenase Homo sapiens 0-23
34884248-1 2021 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role in generating oxidative stress. Uric Acid 61-70 xanthine dehydrogenase Homo sapiens 25-28
34884248-1 2021 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role in generating oxidative stress. Uric Acid 72-74 xanthine dehydrogenase Homo sapiens 0-23
34884248-1 2021 Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role in generating oxidative stress. Uric Acid 72-74 xanthine dehydrogenase Homo sapiens 25-28
34839286-13 2021 Serum uric acid levels were correlated significantly with serum SPX after correcting for BMI and HOMA-IR (r =-0.41, p<0.05). Uric Acid 6-15 spexin hormone Homo sapiens 64-67
34734587-3 2021 Here, we expand the capabilities of a biosensor that leverages the aTF-based regulation of toehold-mediated strand displacement (TMSD) circuits for uric acid (UA) detection in non-invasive salivary samples by utilizing the UA-responsive aTF HucR. Uric Acid 148-157 glial cell derived neurotrophic factor Homo sapiens 67-70
34734587-3 2021 Here, we expand the capabilities of a biosensor that leverages the aTF-based regulation of toehold-mediated strand displacement (TMSD) circuits for uric acid (UA) detection in non-invasive salivary samples by utilizing the UA-responsive aTF HucR. Uric Acid 148-157 glial cell derived neurotrophic factor Homo sapiens 237-240
34734587-3 2021 Here, we expand the capabilities of a biosensor that leverages the aTF-based regulation of toehold-mediated strand displacement (TMSD) circuits for uric acid (UA) detection in non-invasive salivary samples by utilizing the UA-responsive aTF HucR. Uric Acid 159-161 glial cell derived neurotrophic factor Homo sapiens 67-70
34811515-1 2021 Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. Uric Acid 175-184 xanthine dehydrogenase Homo sapiens 0-23
34734587-3 2021 Here, we expand the capabilities of a biosensor that leverages the aTF-based regulation of toehold-mediated strand displacement (TMSD) circuits for uric acid (UA) detection in non-invasive salivary samples by utilizing the UA-responsive aTF HucR. Uric Acid 159-161 glial cell derived neurotrophic factor Homo sapiens 237-240
34811515-1 2021 Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. Uric Acid 175-184 xanthine dehydrogenase Homo sapiens 25-28
34829959-1 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism. Uric Acid 131-140 xanthine dehydrogenase Homo sapiens 0-23
34829959-1 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism. Uric Acid 131-140 xanthine dehydrogenase Homo sapiens 25-28
34829959-4 2021 Three XOR inhibitors are currently used as hyperuricemia and gout therapeutics but are also expected to have potential effects other than uric acid reduction, such as suppressing XO-generating reactive oxygen species. Uric Acid 138-147 xanthine dehydrogenase Homo sapiens 6-9
34830382-9 2021 Overall, GDA upregulation in seborrheic keratosis plays a role in melanogenesis via its metabolic end product uric acid, suggesting that seborrheic keratosis as an example of hyperpigmentation associated with photoaging. Uric Acid 110-119 guanine deaminase Homo sapiens 9-12
34830382-2 2021 Uric acid generated by upregulated guanine deaminase (GDA) has been identified to cause UV-induced keratinocyte senescence in seborrheic keratosis. Uric Acid 0-9 guanine deaminase Homo sapiens 54-57
34830382-5 2021 The objective of this study was to investigate role of GDA and its metabolic end product, uric acid, in hyperpigmentation of patients with seborrheic keratosis using their lesional and non-lesional skin specimen sets and cultured primary human epidermal keratinocytes with or without GDA overexpression or uric acid treatment. Uric Acid 90-99 guanine deaminase Homo sapiens 55-58
34516993-5 2021 KEY FINDINGS: Treatment with STAT3 inhibitor S3I-201 improved renal dysfunction, reduced serum uric acid level, and delayed the progression of kidney fibrosis. Uric Acid 95-104 signal transducer and activator of transcription 3 Mus musculus 29-34
34830382-6 2021 GDA-overexpressing keratinocytes or their conditioned media containing uric acid increased expression levels of MITF and tyrosinase in melanocytes. Uric Acid 71-80 melanocyte inducing transcription factor Homo sapiens 112-116
34830382-6 2021 GDA-overexpressing keratinocytes or their conditioned media containing uric acid increased expression levels of MITF and tyrosinase in melanocytes. Uric Acid 71-80 tyrosinase Homo sapiens 121-131
34830382-7 2021 Uric acid released from keratinocytes was facilitated by ABCG2 transporter with the help of PDZK1 interaction. Uric Acid 0-9 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 57-62
34830382-7 2021 Uric acid released from keratinocytes was facilitated by ABCG2 transporter with the help of PDZK1 interaction. Uric Acid 0-9 PDZ domain containing 1 Homo sapiens 92-97
34830382-8 2021 Released uric acid was taken by URAT1 transporter in melanocytes, stimulating melanogenesis through p38 MAPK activation. Uric Acid 9-18 solute carrier family 22 member 12 Homo sapiens 32-37
34820139-0 2021 Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru. Uric Acid 6-15 insulin Homo sapiens 58-65
34820139-1 2021 We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycan Hospital. Uric Acid 42-51 insulin Homo sapiens 92-99
34789221-10 2021 RESULTS: Exposure to CCl4 and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes and a surge in ALT, AST, ALP, urea, uric acid, bilirubin and creatine kinase. Uric Acid 172-181 C-C motif chemokine ligand 4 Rattus norvegicus 21-25
34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 55-58 interleukin 1 beta Rattus norvegicus 202-220
34834509-2 2021 Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2 gene) together, contribute to enhanced serum uric acid levels. Uric Acid 188-197 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 137-142
34834509-7 2021 The interaction between ABCG2 rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Uric Acid 72-81 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 24-29
34803702-0 2021 Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression. Uric Acid 55-71 toll-like receptor 4 Mus musculus 111-115
34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 268-271 tumor necrosis factor Rattus norvegicus 158-185
34803702-0 2021 Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression. Uric Acid 55-71 myeloid differentiation primary response gene 88 Mus musculus 116-121
34803702-0 2021 Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression. Uric Acid 55-71 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 122-131
34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 268-271 tumor necrosis factor Rattus norvegicus 187-196
34803702-0 2021 Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression. Uric Acid 55-71 NLR family, pyrin domain containing 3 Mus musculus 144-149
34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 268-271 interleukin 1 beta Rattus norvegicus 202-220
34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 268-271 interleukin 1 alpha Rattus norvegicus 222-230
34803702-9 2021 More importantly, the inhibition of TLR4/MyD88/NF-kappaB pathway and NLRP3 expression was also confirmed in MSU-induced Raw264.7 cells. Uric Acid 108-111 toll-like receptor 4 Mus musculus 36-40
34803702-9 2021 More importantly, the inhibition of TLR4/MyD88/NF-kappaB pathway and NLRP3 expression was also confirmed in MSU-induced Raw264.7 cells. Uric Acid 108-111 myeloid differentiation primary response gene 88 Mus musculus 41-46
34803702-9 2021 More importantly, the inhibition of TLR4/MyD88/NF-kappaB pathway and NLRP3 expression was also confirmed in MSU-induced Raw264.7 cells. Uric Acid 108-111 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 47-56
34803702-9 2021 More importantly, the inhibition of TLR4/MyD88/NF-kappaB pathway and NLRP3 expression was also confirmed in MSU-induced Raw264.7 cells. Uric Acid 108-111 NLR family, pyrin domain containing 3 Mus musculus 69-74
34803702-10 2021 In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis. Uric Acid 143-146 toll-like receptor 4 Mus musculus 167-171
34803702-10 2021 In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis. Uric Acid 143-146 myeloid differentiation primary response gene 88 Mus musculus 172-177
34803702-10 2021 In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis. Uric Acid 143-146 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 178-187
34803702-10 2021 In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis. Uric Acid 143-146 NLR family, pyrin domain containing 3 Mus musculus 200-205
34380635-0 2021 Identification of human UDP-glucuronosyltransferase and sulfotransferase as responsible for the metabolism of dotinurad, a novel selective urate reabsorption inhibitor. Uric Acid 139-144 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 24-51
34339053-0 2021 Is there relationship between serum uric acid levels and lower urinary tract symptoms, prostate volume, and PSA in men without cancer? Uric Acid 36-45 aminopeptidase puromycin sensitive Homo sapiens 108-111
34417645-6 2021 The catalytic process of UA with MVSM was studied by a variety of analytical methods, which was similar to the natural uricase except for further oxidation of H2O2. Uric Acid 25-27 urate oxidase (pseudogene) Homo sapiens 119-126
34764684-6 2021 Results: On adjustment for traditional risk factors (age, BMI, ALB, ALK, ASP, calcium, cholesterol, potassium, sodium, total protein, uric acid), SHBG could be regarded as an independent predictor for BMD, while fasting blood glucose did not. Uric Acid 134-143 sex hormone binding globulin Homo sapiens 146-150
34726078-3 2021 Febuxostat, a urate-lowering drug, inhibits BCRP. Uric Acid 14-19 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 44-48
34597788-5 2021 Everybody agrees upon the fact that SGLT2is are different from other classical diuretics (thiazides and loop diuretics) as they present some favourable properties, i.e. reduced sympathetic activity, preserved potassium balance, lower risk of acute renal injury, decrease of serum uric acid level. Uric Acid 280-289 solute carrier family 5 member 2 Homo sapiens 36-41
34790170-4 2021 Burgeoning evidence suggests that the SGLT2 inhibitors possess renal protective activities that are able to lower glycemic levels, improve blood pressure/hemodynamics, cause bodyweight loss, mitigate oxidative stress, exert anti-inflammatory and anti-fibrotic effects, reduce urinary albumin excretion, lower uric acid levels, diminish the activity of intrarenal renin-angiotensin-aldosterone system, and reduce natriuretic peptide levels. Uric Acid 309-318 solute carrier family 5 member 2 Homo sapiens 38-43
34761008-0 2021 Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway. Uric Acid 21-30 kelch like ECH associated protein 1 Homo sapiens 67-72
34606644-10 2021 MSU crystals significantly increased miR-3146 expression and ROS production in neutrophils. Uric Acid 0-3 microRNA 3146 Homo sapiens 37-45
34761008-0 2021 Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway. Uric Acid 21-30 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77
34761008-4 2021 The role of uric acid on vascular endothelial function damaged by ox-LDL, and its effect on the Keap1-Nrf2-ARE pathway has not been fully explored. Uric Acid 12-21 kelch like ECH associated protein 1 Homo sapiens 96-101
34761008-4 2021 The role of uric acid on vascular endothelial function damaged by ox-LDL, and its effect on the Keap1-Nrf2-ARE pathway has not been fully explored. Uric Acid 12-21 NFE2 like bZIP transcription factor 2 Homo sapiens 102-106
34761008-11 2021 In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. Uric Acid 13-22 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35
34761008-11 2021 In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. Uric Acid 13-22 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94
34761008-11 2021 In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. Uric Acid 13-22 kelch like ECH associated protein 1 Homo sapiens 124-129
34761008-11 2021 In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. Uric Acid 13-22 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134
34761008-13 2021 In summary, suitable concentrations of uric acid can alleviate the oxidative stress level of endothelial cells through Nrf2 nuclear translocation and further protect cells from damage. Uric Acid 39-48 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123
34797368-1 2021 Importance: The use of sodium-glucose transport protein 2 (SGLT2) inhibitors is currently a standard intervention in patients with type 2 diabetes (T2DM) and exerts favorable pleiotropic effects to consistently lower blood urate levels. Uric Acid 223-228 solute carrier family 5 member 2 Homo sapiens 23-57
34797368-1 2021 Importance: The use of sodium-glucose transport protein 2 (SGLT2) inhibitors is currently a standard intervention in patients with type 2 diabetes (T2DM) and exerts favorable pleiotropic effects to consistently lower blood urate levels. Uric Acid 223-228 solute carrier family 5 member 2 Homo sapiens 59-64
34836102-11 2021 "Metabolically healthy" patients, but with insulin resistance, had higher blood pressure, glucose, uric acid and triglyceride levels than those without insulin resistance (all p < 0.05). Uric Acid 99-108 insulin Homo sapiens 43-50
34754317-1 2021 Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. Uric Acid 80-89 solute carrier family 22 member 12 Homo sapiens 33-39
34782040-7 2021 Furthermore, ASX administration effectively inhibited the activities of key enzymes related to UA synthesis (xanthine oxidase (XOD) and adenosine deaminase (ADA)) and modulated the protein expressions of NF-kappa B p65, p-NF-kappa B p65, Ikappa Balpha, p-Ikappa Balpha, NLRP3, ASC, Caspase-1, and cleavedCaspase-1 involved in inflammation pathways. Uric Acid 95-97 xanthine dehydrogenase Mus musculus 109-125
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 47-56 agouti related neuropeptide Mus musculus 118-122
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 47-56 pro-opiomelanocortin-alpha Mus musculus 165-169
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 47-56 mitogen-activated protein kinase associated protein 1 Mus musculus 189-193
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 58-60 agouti related neuropeptide Mus musculus 118-122
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 58-60 pro-opiomelanocortin-alpha Mus musculus 165-169
34601428-6 2021 Strikingly, treatment with the ONOO- scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO-, in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Uric Acid 58-60 mitogen-activated protein kinase associated protein 1 Mus musculus 189-193
34777378-0 2021 Galectin-9 Regulates Monosodium Urate Crystal-Induced Gouty Inflammation Through the Modulation of Treg/Th17 Ratio. Uric Acid 21-37 galectin 9 Homo sapiens 0-10
34777378-6 2021 In this study, we sought to comprehensively characterise the functional role of exogenous Gal-9 in an in vivo model of MSU crystal-induced gouty inflammation by monitoring in situ neutrophils, monocytes and Th17/Treg recruited phenotypes and related cyto-chemokines profile. Uric Acid 119-122 galectin 9 Homo sapiens 90-95
34834430-6 2021 Novel biomarkers including NLR, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and uric acid were analyzed and correlated with CK19 expression. Uric Acid 92-101 keratin 19 Homo sapiens 136-140
34834430-10 2021 CONCLUSION: The current study demonstrated the predictive capability of NLR in combination with AFP, CEA and uric acid for CK19 expression in HCC patients preoperatively. Uric Acid 109-118 keratin 19 Homo sapiens 123-127
34674206-9 2021 A pronounced plasma uric acid level is a good indicator of MoCoD. Uric Acid 20-29 molybdenum cofactor synthesis 1 Homo sapiens 59-64
34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 NLR family pyrin domain containing 3 Homo sapiens 38-43
34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 interleukin 1 alpha Homo sapiens 150-154
34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 interleukin 18 Homo sapiens 156-161
34668076-7 2021 The calibration curve showed a linear range of 1 to 70 microg L-1 and 1 to 70 micromol L-1 for Zn2+ and UA, respectively. Uric Acid 104-106 L1 cell adhesion molecule Homo sapiens 62-71
34721647-0 2021 Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF-kappaB Signaling Pathway. Uric Acid 48-51 toll like receptor 4 Homo sapiens 117-121
34721647-0 2021 Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF-kappaB Signaling Pathway. Uric Acid 48-51 nuclear factor kappa B subunit 1 Homo sapiens 122-131
34721647-2 2021 This study aims to investigate whether the total saponin of Dioscorea collettii (TSD) can attenuate monosodium urate (MSU) crystal-induced inflammatory effects by suppressing the activation of the TLR4/NF-kappaB signaling pathway in vivo and in vitro. Uric Acid 100-116 toll like receptor 4 Homo sapiens 197-201
34721647-2 2021 This study aims to investigate whether the total saponin of Dioscorea collettii (TSD) can attenuate monosodium urate (MSU) crystal-induced inflammatory effects by suppressing the activation of the TLR4/NF-kappaB signaling pathway in vivo and in vitro. Uric Acid 100-116 nuclear factor kappa B subunit 1 Homo sapiens 202-211
34721647-12 2021 Conclusion: TSD exhibits an anti-inflammatory effect in the MSU-induced inflammation model, and the mechanism may be to reduce the production of cytokines by inhibiting the activation of the TLR4/NF-kappaB signaling pathway. Uric Acid 60-63 toll like receptor 4 Homo sapiens 191-195
34721647-12 2021 Conclusion: TSD exhibits an anti-inflammatory effect in the MSU-induced inflammation model, and the mechanism may be to reduce the production of cytokines by inhibiting the activation of the TLR4/NF-kappaB signaling pathway. Uric Acid 60-63 nuclear factor kappa B subunit 1 Homo sapiens 196-205
34675606-4 2021 CysC level was correlated with the renal cortex thickness and kidney stones in different uric acid-level groups (P < 0.05). Uric Acid 89-98 cystatin C Homo sapiens 0-4
34118760-4 2021 To address this issue, we focused on the function of uric acid transporter 1 (URAT1), which is selectively permeable to UA. Uric Acid 120-122 solute carrier family 22 member 12 Homo sapiens 53-76
34118760-4 2021 To address this issue, we focused on the function of uric acid transporter 1 (URAT1), which is selectively permeable to UA. Uric Acid 120-122 solute carrier family 22 member 12 Homo sapiens 78-83
34118760-6 2021 To apply URAT1 to a sensor, we developed a KCM-coated UA biosensor (called the KCM sensor) that could selectively detect UA through URAT1. Uric Acid 54-56 solute carrier family 22 member 12 Homo sapiens 9-14
34118760-6 2021 To apply URAT1 to a sensor, we developed a KCM-coated UA biosensor (called the KCM sensor) that could selectively detect UA through URAT1. Uric Acid 54-56 solute carrier family 22 member 12 Homo sapiens 132-137
34118760-6 2021 To apply URAT1 to a sensor, we developed a KCM-coated UA biosensor (called the KCM sensor) that could selectively detect UA through URAT1. Uric Acid 121-123 solute carrier family 22 member 12 Homo sapiens 9-14
34118760-6 2021 To apply URAT1 to a sensor, we developed a KCM-coated UA biosensor (called the KCM sensor) that could selectively detect UA through URAT1. Uric Acid 121-123 solute carrier family 22 member 12 Homo sapiens 132-137
34118760-9 2021 On the other hand, the UA permeability of the KCM sensor was significantly reduced in the presence of a URAT1 inhibitor, implying that URAT1 is a key factor for UA detection. Uric Acid 23-25 solute carrier family 22 member 12 Homo sapiens 104-109
34118760-9 2021 On the other hand, the UA permeability of the KCM sensor was significantly reduced in the presence of a URAT1 inhibitor, implying that URAT1 is a key factor for UA detection. Uric Acid 23-25 solute carrier family 22 member 12 Homo sapiens 135-140
34626042-1 2022 INTRODUCTION: Xanthine oxidoreductase (XOR) is known as an enzyme related to purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. Uric Acid 168-177 xanthine dehydrogenase Homo sapiens 14-37
34626042-1 2022 INTRODUCTION: Xanthine oxidoreductase (XOR) is known as an enzyme related to purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. Uric Acid 168-177 xanthine dehydrogenase Homo sapiens 39-42
34680700-0 2021 Silencing of Aquaporin Homologue Accumulates Uric Acid and Decreases the Lifespan of the Asian Citrus Psyllid, Diaphorina citri (Hemiptera: Liviidae). Uric Acid 45-54 aquaporin AQPAe.a Diaphorina citri 13-22
34680995-3 2021 Genome-wide association studies have revealed that the ABCG2 gene encoding ATP-binding cassette G2 protein was associated with inflammation and higher serum urate concentrations. Uric Acid 157-162 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 55-60
34619144-3 2022 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is related to oxidative stress. Uric Acid 116-125 xanthine dehydrogenase Homo sapiens 0-23
34619144-3 2022 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is related to oxidative stress. Uric Acid 116-125 xanthine dehydrogenase Homo sapiens 25-28
34390315-1 2021 INTRODUCTION: The NLR family pyrin domain containing 3 (NLRP3) signaling pathway has an important role in inflammation mediated by monosodium urate crystals in gout, and the characterization of single nucleotide polymorphisms (SNPs) have helped to recognize disease susceptibility. Uric Acid 131-147 NLR family pyrin domain containing 3 Homo sapiens 18-54
34142949-8 2021 A unit increase in serum albumin was associated with an increase of 6.64 g/L in uric acid (adjusted II beta = 6.64, p = 0.0135). Uric Acid 80-89 albumin Homo sapiens 19-32
34142949-10 2021 The interaction test showed significant interactions between serum albumin and the body mass index (BMI) when hyperuricemia or uric acid were used to determine the outcomes. Uric Acid 127-136 albumin Homo sapiens 61-74
34142949-11 2021 The participants with a BMI >= 25 kg/m2 had a higher OR between serum albumin and hyperuricemia and had a higher beta between serum albumin and uric acid than those with a BMI < 25kg/m2 (for hyperuricemia: OR = 1.01 vs. 1.18, p for interaction = 0.0056; for uric acid: beta = 0.96 vs. 6.23, p for interaction = 0.0154). Uric Acid 144-153 albumin Homo sapiens 132-139
34142949-11 2021 The participants with a BMI >= 25 kg/m2 had a higher OR between serum albumin and hyperuricemia and had a higher beta between serum albumin and uric acid than those with a BMI < 25kg/m2 (for hyperuricemia: OR = 1.01 vs. 1.18, p for interaction = 0.0056; for uric acid: beta = 0.96 vs. 6.23, p for interaction = 0.0154). Uric Acid 258-267 albumin Homo sapiens 132-139
34142949-14 2021 CONCLUSION: Our study showed that serum albumin was positively associated with hyperuricemia and uric acid, especially in obese subjects. Uric Acid 97-106 albumin Homo sapiens 40-47
34118555-7 2021 A wide detection range of 5 microM to 480 microM UA with a high sensitivity of 156.56 microA/mMcm2 and a calculated detection limit (LOD) of 0.018 muM (S/N = 3) were achieved for the UA biosensor. Uric Acid 49-51 minichromosome maintenance complex component 2 Mus musculus 93-98
34133780-3 2021 Recent studies showed that the expression and functional changes of uric acid transporters, including URAT1, GLUT9 and ABCG2, were associated with HU. Uric Acid 68-77 solute carrier family 22 member 12 Homo sapiens 102-107
34133780-3 2021 Recent studies showed that the expression and functional changes of uric acid transporters, including URAT1, GLUT9 and ABCG2, were associated with HU. Uric Acid 68-77 solute carrier family 2 member 9 Homo sapiens 109-114
34133780-3 2021 Recent studies showed that the expression and functional changes of uric acid transporters, including URAT1, GLUT9 and ABCG2, were associated with HU. Uric Acid 68-77 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 119-124
34390315-1 2021 INTRODUCTION: The NLR family pyrin domain containing 3 (NLRP3) signaling pathway has an important role in inflammation mediated by monosodium urate crystals in gout, and the characterization of single nucleotide polymorphisms (SNPs) have helped to recognize disease susceptibility. Uric Acid 131-147 NLR family pyrin domain containing 3 Homo sapiens 56-61
34414459-0 2021 Reactive oxygen species induced by uric acid promote NRK-52E cell apoptosis through the NEK7-NLRP3 signaling pathway. Uric Acid 35-44 NIMA-related kinase 7 Rattus norvegicus 88-92
34414459-0 2021 Reactive oxygen species induced by uric acid promote NRK-52E cell apoptosis through the NEK7-NLRP3 signaling pathway. Uric Acid 35-44 NLR family, pyrin domain containing 3 Rattus norvegicus 93-98
34414459-3 2021 It was hypothesized that UA induces renal tubular epithelial cell injury through reactive oxygen species (ROS) and the Never in mitosis gene A (NIMA)-related kinase 7 (NEK7)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway. Uric Acid 25-27 NIMA-related kinase 7 Rattus norvegicus 119-166
34414459-3 2021 It was hypothesized that UA induces renal tubular epithelial cell injury through reactive oxygen species (ROS) and the Never in mitosis gene A (NIMA)-related kinase 7 (NEK7)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway. Uric Acid 25-27 NIMA-related kinase 7 Rattus norvegicus 168-172
34414459-3 2021 It was hypothesized that UA induces renal tubular epithelial cell injury through reactive oxygen species (ROS) and the Never in mitosis gene A (NIMA)-related kinase 7 (NEK7)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway. Uric Acid 25-27 NLR family, pyrin domain containing 3 Rattus norvegicus 174-210
34414459-3 2021 It was hypothesized that UA induces renal tubular epithelial cell injury through reactive oxygen species (ROS) and the Never in mitosis gene A (NIMA)-related kinase 7 (NEK7)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway. Uric Acid 25-27 NLR family, pyrin domain containing 3 Rattus norvegicus 212-217
34414459-5 2021 Western blotting was performed to determine the expression levels of cleaved caspase-3, Bax and Bcl-xl, it was found that levels were significantly increased after UA treatment in NRK-52E cells. Uric Acid 164-166 caspase 3 Rattus norvegicus 77-86
34311431-5 2021 Interestingly, higher uric acid levels were associated with a slower decline in cognitive scores and brain metabolism in females with MCI, and this effect was found in APOE4 carriers, but not in non-carriers. Uric Acid 22-31 apolipoprotein E Homo sapiens 168-173
34311431-7 2021 In summary, higher serum uric acid may interact with APOE4 to alleviate longitudinal metabolic changes and cognitive decline in female MCI patients. Uric Acid 25-34 apolipoprotein E Homo sapiens 53-58
34414459-5 2021 Western blotting was performed to determine the expression levels of cleaved caspase-3, Bax and Bcl-xl, it was found that levels were significantly increased after UA treatment in NRK-52E cells. Uric Acid 164-166 BCL2 associated X, apoptosis regulator Rattus norvegicus 88-91
34414459-5 2021 Western blotting was performed to determine the expression levels of cleaved caspase-3, Bax and Bcl-xl, it was found that levels were significantly increased after UA treatment in NRK-52E cells. Uric Acid 164-166 Bcl2-like 1 Rattus norvegicus 96-102
34414459-8 2021 The ROS inhibitor, N-acetyl-l-cysteine, exerted a protective effect on the UA-induced apoptosis of tubular epithelial cells by reducing excess ROS production, which significantly inhibited NEK7 and NLRP3 inflammasome activation. Uric Acid 75-77 NLR family, pyrin domain containing 3 Rattus norvegicus 198-203
34684325-10 2021 EM also decreases uric acid uptake into oocytes expressing hURAT1. Uric Acid 18-27 solute carrier family 22 member 12 Homo sapiens 59-65
34438260-5 2021 Our results demonstrated that uric acid at pathological concentrations increased the intracellular levels of ADMA and downregulated DDAH-2 expression without affecting DDAH-1 expression. Uric Acid 30-39 dimethylarginine dimethylaminohydrolase 2 Mus musculus 132-138
34438260-6 2021 Excess uric acid also reduced NO bioavailability and increased monocyte adhesion to ECs, which were abolished by using the antioxidant N-acetylcysteine, the nicotinamide adenine dinucleotide phosphate oxidase inhibitor apocynin, or DDAH-2 overexpression. Uric Acid 7-16 dimethylarginine dimethylaminohydrolase 2 Mus musculus 232-238
34438260-7 2021 In apoe-/- mice, treatment with oxonic acid, a uricase inhibitor, increased the circulating level of uric acid, cholesterol, and lipid peroxidation; exacerbated systemic and aortic inflammation; and worsened atherosclerosis compared with vehicle-treated apoe-/- mice. Uric Acid 101-110 apolipoprotein E Mus musculus 3-7
34215048-8 2021 Moreover, the electrocatalytic behavior for the oxidation of EP and uric acid (UA) on OMC-NiO/GCE surface was investigated. Uric Acid 79-81 epiregulin Homo sapiens 61-63
34215048-9 2021 The result showed that the sensor can be used to selectively determinate EP in the presence of an excesses of UA. Uric Acid 110-112 epiregulin Homo sapiens 73-75
34660620-4 2021 Firstly, NFIL3 expression patterns were determined in the peripheral blood neutrophils of gout patients and monosodium urate (MSU)-treated neutrophils. Uric Acid 108-124 nuclear factor, interleukin 3 regulated Homo sapiens 9-14
34660620-4 2021 Firstly, NFIL3 expression patterns were determined in the peripheral blood neutrophils of gout patients and monosodium urate (MSU)-treated neutrophils. Uric Acid 126-129 nuclear factor, interleukin 3 regulated Homo sapiens 9-14
34660620-6 2021 In addition, gain- or loss-of-function approaches were used to manipulate NFIL3 and REDD1 in both MSU-induced neutrophils and mice. Uric Acid 98-101 nuclear factor, interleukin 3, regulated Mus musculus 74-79
34660620-6 2021 In addition, gain- or loss-of-function approaches were used to manipulate NFIL3 and REDD1 in both MSU-induced neutrophils and mice. Uric Acid 98-101 DNA-damage-inducible transcript 4 Mus musculus 84-89
34660620-8 2021 NFIL3 was highly-expressed in both peripheral blood neutrophils from gout patients and MSU-treated neutrophils. Uric Acid 87-90 nuclear factor, interleukin 3 regulated Homo sapiens 0-5
34576235-4 2021 A significantly positive correlation was found between ceruloplasmin and NYHA class, RV diameter, NT-proBNP, uric acid, total protein, fibrinogen and hepatic enzymes. Uric Acid 109-118 ceruloplasmin Homo sapiens 55-68
34545949-1 2022 Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. Uric Acid 71-80 solute carrier family 5 member 2 Homo sapiens 41-46
34545949-1 2022 Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. Uric Acid 108-117 solute carrier family 5 member 2 Homo sapiens 9-39
34545949-1 2022 Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. Uric Acid 108-117 solute carrier family 5 member 2 Homo sapiens 41-46
34545949-9 2022 SGLT2 inhibitors reduced serum uric acid desirably in patients with T2DM with low HbA1c and high serum uric acid. Uric Acid 31-40 solute carrier family 5 member 2 Homo sapiens 0-5
34545949-9 2022 SGLT2 inhibitors reduced serum uric acid desirably in patients with T2DM with low HbA1c and high serum uric acid. Uric Acid 103-112 solute carrier family 5 member 2 Homo sapiens 0-5
34545949-0 2022 Factors Influencing Change in Serum Uric Acid after Administration of the Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus. Uric Acid 36-45 solute carrier family 5 member 2 Homo sapiens 74-104
34545949-1 2022 Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. Uric Acid 71-80 solute carrier family 5 member 2 Homo sapiens 9-39
34180933-6 2021 Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. Uric Acid 69-71 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-21
34180933-6 2021 Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. Uric Acid 69-71 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 23-28
34180933-6 2021 Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. Uric Acid 123-125 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-21
34180933-6 2021 Glucose transporter 9 (GLUT9) is responsible for the reabsorption of UA in the body, and its inhibition helps downregulate UA levels. Uric Acid 123-125 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 23-28
34180933-8 2021 This research is the first study to demonstrate that RSV effectively inhibits UA uptake via GLUT9 (IC50 = 68.77 muM) in vitro. Uric Acid 78-80 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 92-97
34180933-10 2021 RSV significantly reduced serum UA levels via the downregulation of GLUT9 mRNA and protein expression and promoted the excretion of excess UA through urine. Uric Acid 32-34 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 68-73
34562968-10 2021 High uric acid levels were associated with more than two times higher odds of elevated ALT, AST and GGT (p < 0.001). Uric Acid 5-14 solute carrier family 17 member 5 Homo sapiens 92-95
34562968-10 2021 High uric acid levels were associated with more than two times higher odds of elevated ALT, AST and GGT (p < 0.001). Uric Acid 5-14 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 100-103
34562968-11 2021 Similarly, gender-based target uric acid values were associated with two-fold increased odds of GGT, over one-and-a-half fold higher odds of ALT and AST (p < 0.001). Uric Acid 31-40 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 96-99
34562968-11 2021 Similarly, gender-based target uric acid values were associated with two-fold increased odds of GGT, over one-and-a-half fold higher odds of ALT and AST (p < 0.001). Uric Acid 31-40 solute carrier family 17 member 5 Homo sapiens 149-152
34532198-10 2021 The receiver operating characteristic (ROC) curve and Kaplan-Meier analysis results showed that UA and hs-CRP level had predictive value for three-year cardiovascular-related mortality in CAPD patients (uric acid: area under the curve (AUC)=0.822; hs-CRP: AUC=0.834, p < 0.001). Uric Acid 203-212 C-reactive protein Homo sapiens 106-109
34216576-3 2021 Urate transporter 1 (URAT1) is a major protein involved in uric acid reabsorption (about 90%). Uric Acid 59-68 solute carrier family 22 member 12 Homo sapiens 0-19
34216576-3 2021 Urate transporter 1 (URAT1) is a major protein involved in uric acid reabsorption (about 90%). Uric Acid 59-68 solute carrier family 22 member 12 Homo sapiens 21-26
34594303-0 2021 Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients. Uric Acid 18-23 FAT atypical cadherin 1 Homo sapiens 66-69
34594303-1 2021 Objective: To clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout. Uric Acid 53-58 FAT atypical cadherin 1 Homo sapiens 86-89
34526149-3 2021 The uricase mutation that occurred in the Miocene has been reported to increase serum uric acid and to amplify the effects of fructose to stimulate fat accumulation. Uric Acid 86-95 urate oxidase Mus musculus 4-11
34572357-8 2021 Our results will shed light on a better understanding of SLC2A9-mediated uric acid transport and the development of a uric acid-lowering agent. Uric Acid 73-82 solute carrier family 2 (facilitated glucose transporter), member 9 L homeolog Xenopus laevis 57-63
34494551-1 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and xanthine to uric acid, respectively. Uric Acid 99-108 xanthine dehydrogenase Homo sapiens 0-23
34494551-1 2021 Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and xanthine to uric acid, respectively. Uric Acid 99-108 xanthine dehydrogenase Homo sapiens 25-28
34503865-9 2021 Conversely, loss-of-function polymorphisms in other genes that encode transporters involved in urate excretion (ABCG2, ABCC4) can lead to hyperuricaemia. Uric Acid 95-100 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 112-117
34503865-9 2021 Conversely, loss-of-function polymorphisms in other genes that encode transporters involved in urate excretion (ABCG2, ABCC4) can lead to hyperuricaemia. Uric Acid 95-100 ATP binding cassette subfamily C member 4 Homo sapiens 119-124
34363606-8 2021 Among these, SGLT2 inhibitors reduce blood pressure and serum acid uric levels and can increase hemoglobin levels. Uric Acid 62-71 solute carrier family 5 member 2 Homo sapiens 13-18
34487756-1 2021 AIM: To detect the expression levels of fasting serum fructose and ketohexokinase (KHK) in patients with type 2 diabetes mellitus (T2DM) at different stages of urinary albumin creatinine ratios (UACR) and serum uric acid (sUA). Uric Acid 211-220 ketohexokinase Homo sapiens 67-81
34487756-7 2021 Ridge regression analysis showed that fasting serum fructose and KHK were also correlated with urinary albumin and uric acid (P < 0.05). Uric Acid 115-124 ketohexokinase Homo sapiens 65-68
34487756-8 2021 CONCLUSION: Fasting serum fructose and KHK in endogenous fructose are associated with serum uric acid and urinary albumin levels in patients with T2DM. Uric Acid 92-101 ketohexokinase Homo sapiens 39-42
34420372-10 2021 U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level. Uric Acid 97-102 angiotensin converting enzyme 2 Homo sapiens 2-6
34420372-10 2021 U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level. Uric Acid 205-210 angiotensin converting enzyme 2 Homo sapiens 120-124
34587698-13 2021 After adjustments for triglycerides, BMI, uric acid, HbA1C, 25-OH vitamin D3, alcohol consumption, and anemia, the multiple logistic regression revealed that participants with low TTR levels had a significantly increased risk of BPPV (OR: 5.5; 95% CI, 2.55-11.9; p<0.001). Uric Acid 42-51 transthyretin Homo sapiens 180-183
34117403-1 2021 Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species generation. Uric Acid 72-81 xanthine dehydrogenase Homo sapiens 0-23
34117403-1 2021 Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species generation. Uric Acid 72-81 xanthine dehydrogenase Homo sapiens 25-28
34435469-3 2021 Febuxostat and rasburicase reduce the uric acid concentration by xanthine oxidoreductase inhibition and uric acid degradation into allantoin, respectively. Uric Acid 38-47 xanthine dehydrogenase Homo sapiens 65-88
34507663-5 2021 Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Uric Acid 85-94 membrane metalloendopeptidase Homo sapiens 6-9
34950373-5 2021 The biomarkers are adiponectin, leptin, Leptin/ Adiponectin ratio, TNF-alpha, Interleukin-6, Interleukin-10, PTX3, ghrelin, uric acid, and OxLDL.The elevated plasma levels of adiponectin were linked to the presence of persistent AF. Uric Acid 124-133 adiponectin, C1Q and collagen domain containing Homo sapiens 175-186
34531894-8 2021 Odds ratio (OR) of HUA was analyzed using logistic regression models and the effects of interaction between ABCG2 rs2231142 variants and BMI on serum uric acid level were explored. Uric Acid 150-159 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-113
34562894-3 2021 The heterojunction (single-layer graphene and HfO2 thin-film material) of our graphene-based biosensor worked as a transducer to detect the pH change caused by the specific catalytic reaction between UA and uricase, and hence acquires a UA concentration. Uric Acid 200-202 urate oxidase (pseudogene) Homo sapiens 207-214
34462530-0 2021 Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys. Uric Acid 47-56 sex hormone binding globulin Homo sapiens 106-134
34462530-11 2021 In adolescent boys, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely associated with uric acid after full adjustment. Uric Acid 168-177 sex hormone binding globulin Homo sapiens 109-137
34462530-12 2021 These results suggest that estradiol is not inversely associated with circulating uric acid in adolescents and the establishment of sex difference in circulating uric acid during adolescence is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys. Uric Acid 162-171 sex hormone binding globulin Homo sapiens 240-268
34562894-3 2021 The heterojunction (single-layer graphene and HfO2 thin-film material) of our graphene-based biosensor worked as a transducer to detect the pH change caused by the specific catalytic reaction between UA and uricase, and hence acquires a UA concentration. Uric Acid 237-239 urate oxidase (pseudogene) Homo sapiens 207-214
34432142-6 2022 RESULTS: Annual growth rate, serum levels of thyroid hormones, parathyroid hormone, insulin-like growth factor 1, hemoglobin A1c (HbA1c), uric acid, and alkaline phosphatase show relevant and significant associations with CysC serum concentrations (p <0.001). Uric Acid 138-147 cystatin C Homo sapiens 222-226
34577821-2 2021 The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1beta, which in turn lead to the formation of macromolecular complexes, referred to as inflammasomes. Uric Acid 18-21 interleukin 1 beta Mus musculus 87-104
34577821-7 2021 Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion. Uric Acid 90-93 NLR family, pyrin domain containing 3 Mus musculus 55-60
34577821-7 2021 Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion. Uric Acid 90-93 NLR family, pyrin domain containing 3 Mus musculus 127-132
34577821-7 2021 Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion. Uric Acid 90-93 caspase 1 Rattus norvegicus 142-151
34577821-7 2021 Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion. Uric Acid 90-93 interleukin 1 alpha Rattus norvegicus 167-175
34577821-9 2021 Cardamonin was also shown to attenuate the production of COX-2 in MSU-stimulated J774A.1 macrophage cells. Uric Acid 66-69 cytochrome c oxidase II, mitochondrial Mus musculus 57-62
34577821-11 2021 Conclusions: Overall, cardamonin significantly attenuated IL-1beta secretion, caspase-1 activity, and COX-2 production stimulated by MSU. Uric Acid 133-136 cytochrome c oxidase II, mitochondrial Rattus norvegicus 102-107
34512673-8 2021 TRIM65-deficient mice had a higher production of IL-1beta induced by lipopolysaccharide in sera, and more IL-1beta secretion and neutrophil migration in the ascites, and more severity of joint swelling and associated IL-1beta production induced by monosodium urate, suggesting that TRIM65 deficiency was susceptible to inflammation. Uric Acid 248-264 interleukin 1 alpha Mus musculus 217-225
34432142-8 2022 Multivariate analyses revealed that uric acid and HbA1c are associated variables of CysC independent from gender (p <0.001). Uric Acid 36-45 cystatin C Homo sapiens 84-88
34393228-17 2021 The results of univariate analysis showed that age, gender, preoperative blood uric acid, preoperative urine protein, contralateral renal cyst, and percentage of split renal function of contralateral kidney were correlated with RFC (P < 0.05). Uric Acid 79-88 solute carrier family 19 member 1 Homo sapiens 228-231
34437605-9 2021 The uricase-deficient rats had a significantly higher level of serum uric acid and excreted more uric acid via urine at a higher concentration. Uric Acid 69-78 urate oxidase Rattus norvegicus 4-11
34437605-9 2021 The uricase-deficient rats had a significantly higher level of serum uric acid and excreted more uric acid via urine at a higher concentration. Uric Acid 97-106 urate oxidase Rattus norvegicus 4-11
34437605-10 2021 Except for the liver, uric acid increased in organs and intestinal juice of uricase-deficient rats. Uric Acid 22-31 urate oxidase Rattus norvegicus 76-83
34437605-13 2021 Uricase deficiency causes growth retardation of young male rats and the subsequent increase in serum uric acid results in mild organs injuries, especially in the kidney and liver. Uric Acid 101-110 urate oxidase Rattus norvegicus 0-7
34414940-6 2021 Amounts of circulating GRP78 correlated directly with serum fasting c-peptide, cystatin-c (Cys-c), creatinine (Cr), blood urea nitrogen (BUN), and uric acid, and inversely with glomerular filtration rates. Uric Acid 147-156 heat shock protein family A (Hsp70) member 5 Homo sapiens 23-28
34414940-8 2021 Circulating GRP78 was predicted independently by Cr, BUN, serum uric acid, estimated glomerular filtration rate, and Cys-c, while CHOP depended on age, Cr, BUN, estimated glomerular filtration rate, UmALB/Cr, and Cys-c. Uric Acid 64-73 heat shock protein family A (Hsp70) member 5 Homo sapiens 12-17
34393228-19 2021 The results of multivariate linear regression analysis showed age (P < 0.001), blood uric acid (P < 0.001), urine protein (P=0.002), preoperative eGFR (P < 0.001) and the split renal function of contralateral kidney (P < 0.001) were independent predictors of RFC. Uric Acid 85-94 solute carrier family 19 member 1 Homo sapiens 259-262
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 9-12 NLR family, pyrin domain containing 3 Mus musculus 31-36
34412930-5 2021 CASE PRESENTATION: Here, we report a case of RHUC with increased fractional excretion of uric acid value of more than 100%, serum uric acid level of nearly zero, and exercise-induced AKI episodes clinically and a new unpublished homozygous (biallelic) mutation of c.1419+2T>G (IVS11+2T>G) in the SLC2A9 gene genetically for the first time to our knowledge. Uric Acid 89-98 solute carrier family 2 member 9 Homo sapiens 296-302
34412930-5 2021 CASE PRESENTATION: Here, we report a case of RHUC with increased fractional excretion of uric acid value of more than 100%, serum uric acid level of nearly zero, and exercise-induced AKI episodes clinically and a new unpublished homozygous (biallelic) mutation of c.1419+2T>G (IVS11+2T>G) in the SLC2A9 gene genetically for the first time to our knowledge. Uric Acid 130-139 solute carrier family 2 member 9 Homo sapiens 296-302
34404360-10 2021 Moreover, CFH level was moderately correlated with alkaline phosphatase (ALP) and slightly correlated with age, uric acid (UA) and total bilirubin (TB) in non-GDM (all P < 0.05). Uric Acid 112-121 complement factor H Homo sapiens 10-13
34404360-10 2021 Moreover, CFH level was moderately correlated with alkaline phosphatase (ALP) and slightly correlated with age, uric acid (UA) and total bilirubin (TB) in non-GDM (all P < 0.05). Uric Acid 123-125 complement factor H Homo sapiens 10-13
34383954-1 2021 BACKGROUND: Verinurad is a human uric acid transporter (URAT1) inhibitor known to decrease serum uric acid (sUA) levels and may reduce albuminuria. Uric Acid 97-106 solute carrier family 22 member 12 Homo sapiens 56-61
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 9-12 interleukin 1 beta Mus musculus 65-82
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 9-12 interleukin 1 alpha Mus musculus 84-92
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 179-182 NLR family, pyrin domain containing 3 Mus musculus 31-36
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 179-182 interleukin 1 beta Mus musculus 65-82
34376811-2 2022 Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process. Uric Acid 179-182 interleukin 1 alpha Mus musculus 84-92
34376811-4 2022 Here, we showed that MSU crystal-induced necrosis in murine macrophages was not dependent on NLRP3 inflammasome activation, as neither genetic deletion nor pharmacological blockade of the NLRP3 pathway inhibited the necrosis. Uric Acid 21-24 NLR family, pyrin domain containing 3 Mus musculus 188-193
34376811-9 2022 Altogether, our data indicate that MSU crystals induce NLRP3-independent necrosis, which can be inhibited by combined inhibitors for multiple signaling pathways, highlighting a new avenue for the treatment of gouty arthritis. Uric Acid 35-38 NLR family, pyrin domain containing 3 Mus musculus 55-60
34434930-8 2021 Our data shows MSU crystal but not UA enhances the decidualization response of endometrial stromal cells, via the upregulation of inflammatory genes such Ptgs2 and Il11. Uric Acid 15-18 prostaglandin-endoperoxide synthase 2 Homo sapiens 154-159
34434930-11 2021 In summary, we observed an increased serum UA level in the early stage of women"s pregnancy, and proved that the increased level of UA results from the expressed XDH in decidualizing endometrium of both human and mouse, leading to the formation of MSU crystal. Uric Acid 248-251 xanthine dehydrogenase Homo sapiens 162-165
34434930-8 2021 Our data shows MSU crystal but not UA enhances the decidualization response of endometrial stromal cells, via the upregulation of inflammatory genes such Ptgs2 and Il11. Uric Acid 15-18 interleukin 11 Homo sapiens 164-168
34408667-0 2021 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis. Uric Acid 54-59 insulin Homo sapiens 37-44
34367545-2 2021 Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-kappaB within the endothelial cells and by inducing proinflammatory cytokine release. Uric Acid 0-9 nuclear factor kappa B subunit 1 Homo sapiens 178-187
34377468-7 2021 Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals. Uric Acid 169-185 interleukin 1 alpha Homo sapiens 69-77
34377468-7 2021 Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals. Uric Acid 169-185 NLR family, pyrin domain containing 3 Mus musculus 115-120
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 mitogen-activated protein kinase kinase 7 Homo sapiens 256-259
34408667-1 2021 Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. Uric Acid 66-71 insulin Homo sapiens 0-7
34408667-2 2021 To explore this association further we studied the effects of genetic variation in insulin-associated pathways on serum urate (SU) levels and the physiological effects of insulin on urate transporters. Uric Acid 182-187 insulin Homo sapiens 171-178
34332515-8 2021 A negative correlation was found between APO1/Fas and predisposing factors for metabolic syndrome: Glucose, cholesterol, uric acid, low-density lipoprotein (LDL), and triglycerides. Uric Acid 121-130 Fas cell surface death receptor Homo sapiens 41-45
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin Homo sapiens 53-60
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor Homo sapiens 68-84
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor Homo sapiens 86-90
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor substrate 1 Homo sapiens 97-125
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor substrate 1 Homo sapiens 127-131
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 mitogen-activated protein kinase 1 S homeolog Xenopus laevis 260-263
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin like growth factor 2 Homo sapiens 175-203
34408667-6 2021 Given that the high-capacity urate transporter GLUT9a is the exclusive basolateral exit pathway for reabsorbed urate from the renal proximal tubule into the blood, that insulin stimulates both GLUT9 expression and urate transport activity more than other urate transporters, and that SLC2A9 shows genetic interaction with urate-associated insulin-signaling loci, we postulate that the anti-uricosuric effect of insulin is primarily due to the enhanced expression and activation of GLUT9. Uric Acid 111-116 insulin S homeolog Xenopus laevis 411-418
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor substrate 1 Homo sapiens 205-209
34408667-6 2021 Given that the high-capacity urate transporter GLUT9a is the exclusive basolateral exit pathway for reabsorbed urate from the renal proximal tubule into the blood, that insulin stimulates both GLUT9 expression and urate transport activity more than other urate transporters, and that SLC2A9 shows genetic interaction with urate-associated insulin-signaling loci, we postulate that the anti-uricosuric effect of insulin is primarily due to the enhanced expression and activation of GLUT9. Uric Acid 214-219 insulin S homeolog Xenopus laevis 169-176
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin receptor Homo sapiens 211-215
34408667-6 2021 Given that the high-capacity urate transporter GLUT9a is the exclusive basolateral exit pathway for reabsorbed urate from the renal proximal tubule into the blood, that insulin stimulates both GLUT9 expression and urate transport activity more than other urate transporters, and that SLC2A9 shows genetic interaction with urate-associated insulin-signaling loci, we postulate that the anti-uricosuric effect of insulin is primarily due to the enhanced expression and activation of GLUT9. Uric Acid 214-219 insulin S homeolog Xenopus laevis 411-418
34408667-6 2021 Given that the high-capacity urate transporter GLUT9a is the exclusive basolateral exit pathway for reabsorbed urate from the renal proximal tubule into the blood, that insulin stimulates both GLUT9 expression and urate transport activity more than other urate transporters, and that SLC2A9 shows genetic interaction with urate-associated insulin-signaling loci, we postulate that the anti-uricosuric effect of insulin is primarily due to the enhanced expression and activation of GLUT9. Uric Acid 322-327 insulin S homeolog Xenopus laevis 411-418
34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 solute carrier family 2 member 9 Homo sapiens 286-292
34408667-4 2021 We also found that insulin stimulates the expression of GLUT9 and increases (14C)-urate uptake in human proximal tubular cells (PTC-05) and HEK293T cells, transport activity that was effectively abrogated by uricosurics or inhibitors of protein tyrosine kinase (PTK), PI3 kinase, MEK/ERK, or p38 MAPK. Uric Acid 82-87 insulin Homo sapiens 19-26
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 solute carrier family 22 member 13 S homeolog Xenopus laevis 146-151
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 ornithine aminotransferase L homeolog Xenopus laevis 159-163
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 ATP binding cassette subfamily G member 2 (Junior blood group) L homeolog Xenopus laevis 174-179
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 insulin S homeolog Xenopus laevis 206-213
34120350-3 2021 The silencing of uricase (urate oxidase) activity 15 million years ago enhanced survival by increasing the ability for fructose present in dwindling fruit to be stored as fat, which was a consequence of enhanced uric acid production during fructose metabolism that stimulated lipogenesis and blocked fatty acid oxidation. Uric Acid 212-221 urate oxidase (pseudogene) Homo sapiens 17-24
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog Xenopus laevis 233-243
34408667-5 2021 Heterologous expression of individual urate transporters in Xenopus oocytes revealed that the (14C)-urate transport activities of GLUT9a, GLUT9b, OAT10, OAT3, OAT1, NPT1 and ABCG2 are directly activated by insulin signaling, through PI3 kinase (PI3K)/Akt, MEK/ERK and/or p38 MAPK. Uric Acid 100-105 v-akt murine thymoma viral oncogene homolog 1 S homeolog Xenopus laevis 251-254
34218203-6 2021 The correlation between miR-320a expression and EOPE clinical indicators (mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count) was analyzed. Uric Acid 160-169 microRNA 320a Homo sapiens 24-32
34218203-6 2021 The correlation between miR-320a expression and EOPE clinical indicators (mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count) was analyzed. Uric Acid 171-173 microRNA 320a Homo sapiens 24-32
34440688-0 2021 Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout. Uric Acid 73-89 NLR family, pyrin domain containing 3 Mus musculus 30-35
34244900-4 2021 The results showed that treatment with luteolin and luteoloside reversed the reduction of organic anion transporter 1 (OAT1) levels, while apigenin attenuated the elevation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) levels in uric acid-treated HK-2 cells, which was consistent with the finding in the kidneys of potassium oxonate (PO)-induced mice. Uric Acid 248-257 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 231-236
34251052-14 2021 CONCLUSION: Yi-Suan-Cha may lower uric acid level by downregulating URAT1/GLUT9 expression and upregulating ABCG2/OAT1 expression. Uric Acid 34-43 ATP binding cassette subfamily G member 2 Rattus norvegicus 108-113
34251052-14 2021 CONCLUSION: Yi-Suan-Cha may lower uric acid level by downregulating URAT1/GLUT9 expression and upregulating ABCG2/OAT1 expression. Uric Acid 34-43 solute carrier family 22 member 6 Rattus norvegicus 114-118
34331525-8 2021 Uric acid levels were significantly correlated with BMI (r=0.527), waist circumference (r=0.580), SBP (r=0.497), DBP (r=0.362), TG (r=0.534), total cholesterol (r=0.416), LDLc (r=0.286), HDLc (r=-0.248), insulin (r=0.613), and HOMA-IR index (r=0.607). Uric Acid 0-9 component of oligomeric golgi complex 2 Homo sapiens 171-175
34331525-8 2021 Uric acid levels were significantly correlated with BMI (r=0.527), waist circumference (r=0.580), SBP (r=0.497), DBP (r=0.362), TG (r=0.534), total cholesterol (r=0.416), LDLc (r=0.286), HDLc (r=-0.248), insulin (r=0.613), and HOMA-IR index (r=0.607). Uric Acid 0-9 insulin Homo sapiens 204-211
34244900-4 2021 The results showed that treatment with luteolin and luteoloside reversed the reduction of organic anion transporter 1 (OAT1) levels, while apigenin attenuated the elevation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) levels in uric acid-treated HK-2 cells, which was consistent with the finding in the kidneys of potassium oxonate (PO)-induced mice. Uric Acid 248-257 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 176-195
34244900-4 2021 The results showed that treatment with luteolin and luteoloside reversed the reduction of organic anion transporter 1 (OAT1) levels, while apigenin attenuated the elevation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) levels in uric acid-treated HK-2 cells, which was consistent with the finding in the kidneys of potassium oxonate (PO)-induced mice. Uric Acid 248-257 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 197-202
34244900-4 2021 The results showed that treatment with luteolin and luteoloside reversed the reduction of organic anion transporter 1 (OAT1) levels, while apigenin attenuated the elevation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) levels in uric acid-treated HK-2 cells, which was consistent with the finding in the kidneys of potassium oxonate (PO)-induced mice. Uric Acid 248-257 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 208-229
34440688-2 2021 Macrophages intake MSU crystals, the trigger for NLRP3 inflammasome activation, which leads to the release of interleukin (IL)-1beta and results in the flaring of gout. Uric Acid 19-22 NLR family, pyrin domain containing 3 Mus musculus 49-54
34440688-2 2021 Macrophages intake MSU crystals, the trigger for NLRP3 inflammasome activation, which leads to the release of interleukin (IL)-1beta and results in the flaring of gout. Uric Acid 19-22 interleukin 1 alpha Mus musculus 110-132
34440688-3 2021 The effects of temperature, an environmental factor for MSU crystallization, on IL-1beta secretion have not been well studied. Uric Acid 56-59 interleukin 1 alpha Mus musculus 80-88
34440688-8 2021 MSU crystals at lower temperatures enhanced IL-1beta secretion via the NLRP3 inflammasome pathway. Uric Acid 0-3 interleukin 1 alpha Mus musculus 44-52
34440688-8 2021 MSU crystals at lower temperatures enhanced IL-1beta secretion via the NLRP3 inflammasome pathway. Uric Acid 0-3 NLR family, pyrin domain containing 3 Mus musculus 71-76
34335041-6 2021 Res inhibits the MSU-induced activation of NLRP3 inflammasomes by reducing the levels of IL-1beta, IL-18, and Caspase-1 and the pyroptosis of macrophages. Uric Acid 17-20 NLR family, pyrin domain containing 3 Rattus norvegicus 43-48
34321071-2 2021 Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1beta. Uric Acid 0-5 interleukin 1 alpha Homo sapiens 87-95
34385934-0 2021 Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Uric Acid 64-73 chemokine (C-X-C motif) receptor 2 Mus musculus 12-44
34385934-0 2021 Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Uric Acid 64-73 chemokine (C-X-C motif) receptor 2 Mus musculus 46-51
34385934-0 2021 Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Uric Acid 75-77 chemokine (C-X-C motif) receptor 2 Mus musculus 12-44
34385934-0 2021 Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Uric Acid 75-77 chemokine (C-X-C motif) receptor 2 Mus musculus 46-51
34385934-2 2021 C-X-C motif chemokine ligand 1 (CXCL1) was upregulated in renal tubules from mice subjected to uric acid (UA)-induced nephropathy. Uric Acid 95-104 chemokine (C-X-C motif) ligand 1 Mus musculus 0-30
34385934-2 2021 C-X-C motif chemokine ligand 1 (CXCL1) was upregulated in renal tubules from mice subjected to uric acid (UA)-induced nephropathy. Uric Acid 95-104 chemokine (C-X-C motif) ligand 1 Mus musculus 32-37
34385934-2 2021 C-X-C motif chemokine ligand 1 (CXCL1) was upregulated in renal tubules from mice subjected to uric acid (UA)-induced nephropathy. Uric Acid 106-108 chemokine (C-X-C motif) ligand 1 Mus musculus 0-30
34385934-2 2021 C-X-C motif chemokine ligand 1 (CXCL1) was upregulated in renal tubules from mice subjected to uric acid (UA)-induced nephropathy. Uric Acid 106-108 chemokine (C-X-C motif) ligand 1 Mus musculus 32-37
34385934-3 2021 Given that CXCL1 is a master chemokine responsible for the recruitment of macrophage by binding with its receptor C-X-C motif chemokine receptor 2 (CXCR2), we thus hypothesized that UA-induced cardiac injury is via promoting the recruitment of CXCR2 + macrophages into the heart, which enhances cardiac inflammation. Uric Acid 182-184 chemokine (C-X-C motif) ligand 1 Mus musculus 11-16
34385934-3 2021 Given that CXCL1 is a master chemokine responsible for the recruitment of macrophage by binding with its receptor C-X-C motif chemokine receptor 2 (CXCR2), we thus hypothesized that UA-induced cardiac injury is via promoting the recruitment of CXCR2 + macrophages into the heart, which enhances cardiac inflammation. Uric Acid 182-184 chemokine (C-X-C motif) receptor 2 Mus musculus 114-146
34385934-3 2021 Given that CXCL1 is a master chemokine responsible for the recruitment of macrophage by binding with its receptor C-X-C motif chemokine receptor 2 (CXCR2), we thus hypothesized that UA-induced cardiac injury is via promoting the recruitment of CXCR2 + macrophages into the heart, which enhances cardiac inflammation. Uric Acid 182-184 chemokine (C-X-C motif) receptor 2 Mus musculus 148-153
34385934-3 2021 Given that CXCL1 is a master chemokine responsible for the recruitment of macrophage by binding with its receptor C-X-C motif chemokine receptor 2 (CXCR2), we thus hypothesized that UA-induced cardiac injury is via promoting the recruitment of CXCR2 + macrophages into the heart, which enhances cardiac inflammation. Uric Acid 182-184 chemokine (C-X-C motif) receptor 2 Mus musculus 244-249
34385934-6 2021 We found a high plasma level of UA-induced upregulation of CXCL1 in heart tissues. Uric Acid 32-34 chemokine (C-X-C motif) ligand 1 Mus musculus 59-64
34385934-8 2021 The silencing of CXCR2 in human monocytes abolished the migration of UA-induced monocyte. Uric Acid 69-71 C-X-C motif chemokine receptor 2 Homo sapiens 17-22
34385934-9 2021 Thus, the interventions against CXCL1/CXCR2 may be effective for the prevention and treatment of UA-induced cardiac hypertrophy and inflammatory responses. Uric Acid 97-99 C-X-C motif chemokine ligand 1 Homo sapiens 32-37
34385934-9 2021 Thus, the interventions against CXCL1/CXCR2 may be effective for the prevention and treatment of UA-induced cardiac hypertrophy and inflammatory responses. Uric Acid 97-99 C-X-C motif chemokine receptor 2 Homo sapiens 38-43
34369352-7 2021 In the murine acute gout model, MSU injection increased NF-kappaB activity and oral administration of TCJC significantly reduced NF-kappaB activity in mouse foot, and ankle joints as assessed by IVIS analysis. Uric Acid 32-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 56-65
34369352-11 2021 Clinically relevant doses of TCJC significantly inhibit inflammation and NF-kappaB activation induced by MSU crystals. Uric Acid 105-108 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 73-82
34349551-0 2021 Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus. Uric Acid 20-29 insulin like growth factor 1 Homo sapiens 34-62
34349551-1 2021 Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 59-68 insulin like growth factor 1 Homo sapiens 78-106
34349551-1 2021 Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 59-68 insulin like growth factor 1 Homo sapiens 108-113
34335041-6 2021 Res inhibits the MSU-induced activation of NLRP3 inflammasomes by reducing the levels of IL-1beta, IL-18, and Caspase-1 and the pyroptosis of macrophages. Uric Acid 17-20 interleukin 1 alpha Rattus norvegicus 89-97
34335041-6 2021 Res inhibits the MSU-induced activation of NLRP3 inflammasomes by reducing the levels of IL-1beta, IL-18, and Caspase-1 and the pyroptosis of macrophages. Uric Acid 17-20 interleukin 18 Rattus norvegicus 99-104
34335041-6 2021 Res inhibits the MSU-induced activation of NLRP3 inflammasomes by reducing the levels of IL-1beta, IL-18, and Caspase-1 and the pyroptosis of macrophages. Uric Acid 17-20 caspase 1 Rattus norvegicus 110-119
34284768-10 2021 In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA. Uric Acid 67-70 NLR family, pyrin domain containing 3 Mus musculus 13-18
34227626-5 2021 We notice that Vit-C encapsulates the aggregated UA. Uric Acid 49-51 vitrin Homo sapiens 15-18
34227626-8 2021 We perceive that, through hydrogen bonding and aromatic stacking interactions, Vit-C molecules interact with UA molecules. Uric Acid 109-111 vitrin Homo sapiens 79-82
34227626-9 2021 The determination of the Flory-Huggins interaction parameters suggests that the presence of Vit-C enhances the solubility of UA aggregates. Uric Acid 125-127 vitrin Homo sapiens 92-95
34227626-11 2021 Vit-C, however, encapsulates and disseminates itself within the aggregated UA molecules on the surface. Uric Acid 75-77 vitrin Homo sapiens 0-3
34284768-10 2021 In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA. Uric Acid 67-70 caspase 1 Mus musculus 20-29
34284768-10 2021 In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA. Uric Acid 67-70 interleukin 1 alpha Mus musculus 34-42
34335573-0 2021 Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals. Uric Acid 103-106 zinc finger protein 36 Mus musculus 10-25
34335573-11 2021 Oral administration of Arctigenin significantly alleviated foot pad swelling, the number of inflammatory cells in peritoneal lavage fluids and the production of IL-1beta in the mouse model of inflammation induced by MSU crystals. Uric Acid 216-219 interleukin 1 alpha Mus musculus 161-169
34335573-12 2021 Collectively, these data imply that targeting TTP expression or functional activity may provide a potential therapeutic strategy for inflammation caused by MSU crystals. Uric Acid 156-159 zinc finger protein 36 Mus musculus 46-49
34160066-8 2021 A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL-6/JAK2/STAT3 signaling pathway. Uric Acid 140-156 interleukin 6 Rattus norvegicus 213-217
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 44-47 NLR family, pyrin domain containing 3 Mus musculus 336-341
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 44-47 tumor necrosis factor Mus musculus 346-355
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 109-112 NLR family, pyrin domain containing 3 Mus musculus 336-341
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 109-112 tumor necrosis factor Mus musculus 346-355
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 170-173 NLR family, pyrin domain containing 3 Mus musculus 336-341
34359507-3 2021 Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha). Uric Acid 170-173 tumor necrosis factor Mus musculus 346-355
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 17 member 1 Homo sapiens 40-44
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 17 member 3 Homo sapiens 46-50
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 potassium two pore domain channel subfamily K member 3 Homo sapiens 52-56
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 22 member 7 Homo sapiens 58-62
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 22 member 8 Homo sapiens 64-68
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 22 member 9 Homo sapiens 70-74
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 22 member 12 Homo sapiens 76-81
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 solute carrier family 2 member 9 Homo sapiens 83-88
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 90-95
34335246-5 2021 According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Uric Acid 156-165 PDZ domain containing 1 Homo sapiens 97-102
34255797-9 2021 Alterations in Bcrp/Pgp dKO CSF levels of antioxidants, precursors of neurotransmitters, and uric acid suggests the transporters may contribute to the regulation of a healthy central nervous system in rats. Uric Acid 93-102 phosphoglycolate phosphatase Rattus norvegicus 20-23
34247797-7 2021 The area under the ROC curve was statistically significant for cystatin C, uric acid and creatinine, but of these three values, cystatin C had the highest sensitivity and specificity. Uric Acid 75-84 cystatin C Homo sapiens 128-138
34061595-13 2021 The effect of uric acid was confirmed by administration of allopurinol, an inhibitor of xanthine oxidase. Uric Acid 14-23 xanthine dehydrogenase Mus musculus 88-104
34322499-10 2021 In the Cox multivariate model, high levels of baseline TNFR predicted a 30% eGFR decline, even after adjusting for age, sex, systolic blood pressure, high sensitivity C-reactive protein, uric acid, and presence or absence of febuxostat treatment and diabetes, in addition to baseline albumin to creatinine ratio and eGFR. Uric Acid 187-196 TNF receptor superfamily member 1A Homo sapiens 55-59
34125892-3 2021 Recently, the NMT1 RNA motif has been identified to selectively bind xanthine and uric acid, respectively, both are involved in the metabolic pathway of purine degradation. Uric Acid 82-91 N-myristoyltransferase 1 Homo sapiens 14-18
34278996-2 2021 The features of IgAN are also affected by uric acid, but its effect on the prognosis is less reported. Uric Acid 42-51 IGAN1 Homo sapiens 16-20
34209068-6 2021 The excellent anti-interference ability to ascorbic and uric acids and successful practical application for glucose determination in serum samples was presented for GR/PANI-AuNPs(6 nm)-GOx/GOx electrode. Uric Acid 56-66 hydroxyacid oxidase 1 Homo sapiens 185-188
34160066-8 2021 A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL-6/JAK2/STAT3 signaling pathway. Uric Acid 158-161 interleukin 6 Rattus norvegicus 213-217
34160066-8 2021 A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL-6/JAK2/STAT3 signaling pathway. Uric Acid 158-161 Janus kinase 2 Rattus norvegicus 218-222
34160066-8 2021 A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL-6/JAK2/STAT3 signaling pathway. Uric Acid 158-161 signal transducer and activator of transcription 3 Rattus norvegicus 223-228
34144706-0 2021 Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway. Uric Acid 48-53 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 31-36
34293840-8 2022 Birds reared in cage and fed with 140 and 150 g/kg CP presented lower uric acid. Uric Acid 70-79 ceruloplasmin Gallus gallus 51-53
34234773-5 2021 Stimulating neutrophils with uric acid crystals, the etiological agent of gout, drove the hyperphosphorylation of p38 and Akt. Uric Acid 29-38 mitogen-activated protein kinase 14 Homo sapiens 114-117
34234773-5 2021 Stimulating neutrophils with uric acid crystals, the etiological agent of gout, drove the hyperphosphorylation of p38 and Akt. Uric Acid 29-38 AKT serine/threonine kinase 1 Homo sapiens 122-125
34234773-6 2021 Ultimately, one of the pathways through which CLEC12A regulates uric acid crystal-stimulated release of IL-8 by neutrophils is through a p38/PI3K-Akt signaling pathway. Uric Acid 64-73 C-type lectin domain family 12 member A Homo sapiens 46-53
34234773-6 2021 Ultimately, one of the pathways through which CLEC12A regulates uric acid crystal-stimulated release of IL-8 by neutrophils is through a p38/PI3K-Akt signaling pathway. Uric Acid 64-73 C-X-C motif chemokine ligand 8 Homo sapiens 104-108
34234773-6 2021 Ultimately, one of the pathways through which CLEC12A regulates uric acid crystal-stimulated release of IL-8 by neutrophils is through a p38/PI3K-Akt signaling pathway. Uric Acid 64-73 mitogen-activated protein kinase 14 Homo sapiens 137-145
34234773-6 2021 Ultimately, one of the pathways through which CLEC12A regulates uric acid crystal-stimulated release of IL-8 by neutrophils is through a p38/PI3K-Akt signaling pathway. Uric Acid 64-73 AKT serine/threonine kinase 1 Homo sapiens 146-149
34176482-12 2021 BMI in men and among drinkers, and uric acid among drinkers were negatively correlated with ERBB3 levels. Uric Acid 35-44 erb-b2 receptor tyrosine kinase 3 Homo sapiens 92-97
34206432-4 2021 In this context, genome-wide association studies and subsequent functional analyses have identified the ATP-binding cassette (ABC) transporter ABCG2 as an important urate transporter and have highlighted the role of single nucleotide polymorphisms (SNPs) in the pathogenesis of reduced cellular urate efflux, hyperuricemia, and early-onset gout. Uric Acid 295-300 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 143-148
34206432-5 2021 Recent publications also suggest that ABCG2 is particularly involved in intestinal urate elimination and thus may represent an interesting new target for pharmacotherapeutic intervention in hyperuricemia and gout. Uric Acid 83-88 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 38-43
34206432-6 2021 In this review, we specifically address the involvement of ABCG2 in renal and extrarenal urate elimination. Uric Acid 89-94 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 59-64
34148058-0 2021 Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. Uric Acid 106-115 insulin Homo sapiens 21-28
34148058-2 2021 However, the role of insulin resistance in the relationship between serum uric acid and hypertension is still unelucidated. Uric Acid 74-83 insulin Homo sapiens 21-28
34148058-3 2021 Based on a prospective cohort study, we aimed to examine the longitudinal link between serum uric acid and hypertension and whether this relationship was mediated by insulin resistance. Uric Acid 93-102 insulin Homo sapiens 166-173
34148058-5 2021 Adjusted Cox-regression analyses and mediation analyses were performed to assess the risk of hypertension by serum uric acid quartile distribution and whether insulin resistance mediated the association between serum uric acid and hypertension. Uric Acid 217-226 insulin Homo sapiens 159-166
34148058-11 2021 Elevated serum uric acid levels are associated with an increased risk of incident hypertension, and insulin resistance may play a mediating role in the relationship between serum uric acid and hypertension. Uric Acid 179-188 insulin Homo sapiens 100-107
34144706-8 2021 Estradiol has been confirmed to promote urate transport by upregulating ABCG2 expression in intestinal urate excretion models in vivo and in vitro. Uric Acid 40-45 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 72-77
34144706-8 2021 Estradiol has been confirmed to promote urate transport by upregulating ABCG2 expression in intestinal urate excretion models in vivo and in vitro. Uric Acid 103-108 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 72-77
34144706-10 2021 CONCLUSION: Our study revealed that estradiol regulates intestinal ABCG2 through the PI3K/Akt pathway to promote urate excretion, thereby reducing serum urate levels. Uric Acid 113-118 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 67-72
34144706-10 2021 CONCLUSION: Our study revealed that estradiol regulates intestinal ABCG2 through the PI3K/Akt pathway to promote urate excretion, thereby reducing serum urate levels. Uric Acid 113-118 thymoma viral proto-oncogene 1 Mus musculus 90-93
34144706-10 2021 CONCLUSION: Our study revealed that estradiol regulates intestinal ABCG2 through the PI3K/Akt pathway to promote urate excretion, thereby reducing serum urate levels. Uric Acid 153-158 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 67-72
34144706-0 2021 Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway. Uric Acid 48-53 thymoma viral proto-oncogene 1 Mus musculus 77-80
34144706-10 2021 CONCLUSION: Our study revealed that estradiol regulates intestinal ABCG2 through the PI3K/Akt pathway to promote urate excretion, thereby reducing serum urate levels. Uric Acid 153-158 thymoma viral proto-oncogene 1 Mus musculus 90-93
34144706-2 2021 In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway. Uric Acid 153-158 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 80-121
34144706-2 2021 In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway. Uric Acid 153-158 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 123-128
34144706-2 2021 In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway. Uric Acid 153-158 thymoma viral proto-oncogene 1 Mus musculus 186-189
34177800-10 2021 The level of plasma RBP4 was positively correlated with plasma uric acid, creatinine, fasting insulin, IR index, total cholesterol and triglyceride levels in patients with HUA. Uric Acid 63-72 retinol binding protein 4 Homo sapiens 20-24
34239940-0 2021 Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes. Uric Acid 57-66 solute carrier family 5 member 2 Homo sapiens 0-30
34239940-0 2021 Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes. Uric Acid 57-66 solute carrier family 5 member 2 Homo sapiens 32-38
34239940-3 2021 The goal of this study was to compare the effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors dapagliflozin and empagliflozin on serum uric acid (SUA) levels in patients with type 2 diabetes against traditional oral antihyperglycemic drugs (OADs). Uric Acid 144-153 solute carrier family 5 member 2 Homo sapiens 52-82
34239940-3 2021 The goal of this study was to compare the effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors dapagliflozin and empagliflozin on serum uric acid (SUA) levels in patients with type 2 diabetes against traditional oral antihyperglycemic drugs (OADs). Uric Acid 144-153 solute carrier family 5 member 2 Homo sapiens 84-90
34163195-0 2021 The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study. Uric Acid 25-34 insulin Homo sapiens 63-70
34163195-3 2021 We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes. Uric Acid 170-179 insulin Homo sapiens 63-70
34177800-11 2021 In HUA rats, the level of plasma RBP4 was positively correlated with plasma uric acid, IR index, and triglycerides. Uric Acid 76-85 retinol binding protein 4 Rattus norvegicus 33-37
34290818-7 2021 In the proximal tubule, urate reabsorption is mainly mediated by apical URAT1 (SLC22A12) and basolateral GLUT9 (SLC2A9) transporter. Uric Acid 24-29 solute carrier family 22 member 12 Homo sapiens 72-77
34212036-13 2021 MSU depositions enveloped by inflammatory cells that express IL-1beta and TNF-alpha were detected in embedding groups. Uric Acid 0-3 interleukin 1 alpha Rattus norvegicus 61-69
34212036-13 2021 MSU depositions enveloped by inflammatory cells that express IL-1beta and TNF-alpha were detected in embedding groups. Uric Acid 0-3 tumor necrosis factor Rattus norvegicus 74-83
34212036-14 2021 Quantitative immunofluorescence suggested that the frequencies of MSU interventions upregulated expression of proinflammatory factors including IL-1beta and TNF-alpha (P < 0.05). Uric Acid 66-69 interleukin 1 alpha Rattus norvegicus 144-152
34212036-14 2021 Quantitative immunofluorescence suggested that the frequencies of MSU interventions upregulated expression of proinflammatory factors including IL-1beta and TNF-alpha (P < 0.05). Uric Acid 66-69 tumor necrosis factor Rattus norvegicus 157-166
34237812-0 2021 Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury. Uric Acid 0-9 albumin Homo sapiens 10-17
34150796-4 2021 SGLT2is lower glycated hemoglobin (HbA1c) without increasing the risk of hypoglycemia, induce weight loss and improve various metabolic parameters including BP, lipid profile, albuminuria and uric acid. Uric Acid 192-201 solute carrier family 5 member 2 Homo sapiens 0-5
34118855-1 2021 BACKGROUND: Previous studies have suggested benefits of SGLT2 inhibitors including improving glycemic control, lower body weight, uric acid-lowering effect and decreasing blood pressure. Uric Acid 130-139 solute carrier family 5 member 2 Homo sapiens 56-61
34290818-7 2021 In the proximal tubule, urate reabsorption is mainly mediated by apical URAT1 (SLC22A12) and basolateral GLUT9 (SLC2A9) transporter. Uric Acid 24-29 solute carrier family 22 member 12 Homo sapiens 79-87
34290818-7 2021 In the proximal tubule, urate reabsorption is mainly mediated by apical URAT1 (SLC22A12) and basolateral GLUT9 (SLC2A9) transporter. Uric Acid 24-29 solute carrier family 2 member 9 Homo sapiens 105-110
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 70-79 vascular cell adhesion molecule 1 Homo sapiens 197-202
34290818-7 2021 In the proximal tubule, urate reabsorption is mainly mediated by apical URAT1 (SLC22A12) and basolateral GLUT9 (SLC2A9) transporter. Uric Acid 24-29 solute carrier family 2 member 9 Homo sapiens 112-118
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 70-79 intercellular adhesion molecule 1 Homo sapiens 204-209
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 70-79 cellular communication network factor 1 Homo sapiens 211-216
34290818-8 2021 OAT4 (SLC22A11) also acts in urate reabsorption in the apical membrane, and its polymorphism is associated with the risk of hyperuricemia. Uric Acid 29-34 solute carrier family 22 member 11 Homo sapiens 0-4
34290818-8 2021 OAT4 (SLC22A11) also acts in urate reabsorption in the apical membrane, and its polymorphism is associated with the risk of hyperuricemia. Uric Acid 29-34 solute carrier family 22 member 11 Homo sapiens 6-14
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 70-79 cyclin A1 Homo sapiens 218-223
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 22 member 6 Homo sapiens 43-47
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 70-79 E2F transcription factor 1 Homo sapiens 229-233
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 22 member 6 Homo sapiens 49-56
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 81-83 vascular cell adhesion molecule 1 Homo sapiens 197-202
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 81-83 intercellular adhesion molecule 1 Homo sapiens 204-209
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 81-83 cellular communication network factor 1 Homo sapiens 211-216
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 81-83 cyclin A1 Homo sapiens 218-223
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 22 member 8 Homo sapiens 62-66
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 22 member 8 Homo sapiens 68-75
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 88-132
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 134-139
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 17 member 1 Homo sapiens 142-146
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 81-83 E2F transcription factor 1 Homo sapiens 229-233
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 86-102 vascular cell adhesion molecule 1 Homo sapiens 197-202
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 17 member 1 Homo sapiens 148-155
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 86-102 intercellular adhesion molecule 1 Homo sapiens 204-209
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 17 member 3 Homo sapiens 162-166
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 86-102 cellular communication network factor 1 Homo sapiens 211-216
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 86-102 cyclin A1 Homo sapiens 218-223
34290818-12 2021 Urate secretion is mediated by basolateral OAT1 (SLC22A6) and OAT3 (SLC22A8) and apical ATP-binding cassette super-family G member 2 (ABCG2), NPT1 (SLC17A1), and NPT4 (SLC17A3) transporter in the proximal tubule. Uric Acid 0-5 solute carrier family 17 member 3 Homo sapiens 168-175
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 86-102 E2F transcription factor 1 Homo sapiens 229-233
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 104-107 vascular cell adhesion molecule 1 Homo sapiens 197-202
34290818-13 2021 NPT1 and NPT4 may be key players in renal urate secretion in humans, and deletion of SLC22A6 and SLC22A8 in mice leads to decreased urate excretion. Uric Acid 42-47 solute carrier family 17 member 1 Homo sapiens 0-4
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 104-107 intercellular adhesion molecule 1 Homo sapiens 204-209
34290818-13 2021 NPT1 and NPT4 may be key players in renal urate secretion in humans, and deletion of SLC22A6 and SLC22A8 in mice leads to decreased urate excretion. Uric Acid 42-47 solute carrier family 17 member 3 Homo sapiens 9-13
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 104-107 cellular communication network factor 1 Homo sapiens 211-216
34290818-13 2021 NPT1 and NPT4 may be key players in renal urate secretion in humans, and deletion of SLC22A6 and SLC22A8 in mice leads to decreased urate excretion. Uric Acid 132-137 solute carrier family 22 member 6 Homo sapiens 85-92
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 104-107 cyclin A1 Homo sapiens 218-223
33977576-2 2021 Experiments using human umbilical vein endothelial cells treated with uric acid (UA), monosodium urate (MSU), or serum from gout patients showed increased expression of pro-inflammatory genes (ie, VCAM1, ICAM1, CYR61, CCNA1, and E2F1) with attendant increase in monocyte adhesion. Uric Acid 104-107 E2F transcription factor 1 Homo sapiens 229-233
34290818-13 2021 NPT1 and NPT4 may be key players in renal urate secretion in humans, and deletion of SLC22A6 and SLC22A8 in mice leads to decreased urate excretion. Uric Acid 132-137 solute carrier family 22 member 8 Homo sapiens 97-104
33977576-3 2021 Mechanistically, UA- or MSU-induced SREBP2 expression and its transcriptional activity. Uric Acid 17-19 sterol regulatory element binding transcription factor 2 Homo sapiens 36-42
33977576-3 2021 Mechanistically, UA- or MSU-induced SREBP2 expression and its transcriptional activity. Uric Acid 24-27 sterol regulatory element binding transcription factor 2 Homo sapiens 36-42
34290818-14 2021 Dysfunctional variants of ABCG2 inhibit urate secretion from the gut and kidney and may cause gout. Uric Acid 40-45 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 26-31
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 22 member 12 Homo sapiens 138-143
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 22 member 11 Homo sapiens 145-149
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 2 member 9 Homo sapiens 155-160
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 177-182
33977576-5 2021 The SREBP2 knockdown by siRNA partially abolished UA- or MSU-induced YAP activity, pro-inflammatory gene expression, and monocytes adhesion. Uric Acid 50-52 Yes1 associated transcriptional regulator Homo sapiens 69-72
33977576-5 2021 The SREBP2 knockdown by siRNA partially abolished UA- or MSU-induced YAP activity, pro-inflammatory gene expression, and monocytes adhesion. Uric Acid 57-60 Yes1 associated transcriptional regulator Homo sapiens 69-72
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 17 (sodium phosphate), member 1 Mus musculus 184-188
33977576-9 2021 Collectively, UA or MSU causes endothelial dysfunction via SREBP2 transactivation of YAP. Uric Acid 14-16 sterol regulatory element binding transcription factor 2 Homo sapiens 59-65
33977576-9 2021 Collectively, UA or MSU causes endothelial dysfunction via SREBP2 transactivation of YAP. Uric Acid 14-16 Yes1 associated transcriptional regulator Homo sapiens 85-88
33977576-9 2021 Collectively, UA or MSU causes endothelial dysfunction via SREBP2 transactivation of YAP. Uric Acid 20-23 sterol regulatory element binding transcription factor 2 Homo sapiens 59-65
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 17 (sodium phosphate), member 3 Mus musculus 190-194
33977576-9 2021 Collectively, UA or MSU causes endothelial dysfunction via SREBP2 transactivation of YAP. Uric Acid 20-23 Yes1 associated transcriptional regulator Homo sapiens 85-88
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 22 member 6 Homo sapiens 196-200
34290818-15 2021 In summary, the net result of urate transport in the proximal tubule is determined by the dominance of transporters between reabsorption (URAT1, OAT4, and GLUT9) and secretion (ABCG2, NPT1, NPT4, OAT1, and OAT3). Uric Acid 30-35 solute carrier family 22 member 8 Homo sapiens 206-210
34063875-7 2021 Elevated CRP was observed using simple linear regressions in patients with type II diabetes, higher cumulative joint scores, increased number of affected joints, as well as elevated uric acid, erythrocyte sedimentation rate, and leukocyte count. Uric Acid 182-191 C-reactive protein Homo sapiens 9-12
34307206-0 2021 Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction. Uric Acid 0-9 albumin Homo sapiens 13-20
34307206-1 2021 Objective: This research aimed to investigate the predictive value of the uric acid-to-serum albumin ratio (UAR) in establishing the severity and extent of coronary artery disease (CAD) with non-ST segment elevation myocardial infarction (NSTEMI) patients. Uric Acid 74-83 albumin Homo sapiens 93-100
34063373-9 2021 Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients. Uric Acid 22-31 periostin Homo sapiens 86-95
34248038-8 2021 Leptin levels in the group of healthy individuals correlated with a waist circumference (r=0.78, p=0.005), BFM, BMI and age (r=0.92, r=0.94, r=0.81, p<0 , 05), uric acid levels (r=0.94) and ionized calcium (r=0.91) at p<0.05. Uric Acid 160-169 leptin Homo sapiens 0-6
34268385-0 2021 Analysis of gender-specific associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms and serum uric acid levels in Han Chinese. Uric Acid 120-129 aldehyde dehydrogenase 2 family member Homo sapiens 49-73
34268385-0 2021 Analysis of gender-specific associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms and serum uric acid levels in Han Chinese. Uric Acid 120-129 aldehyde dehydrogenase 2 family member Homo sapiens 75-80
34248038-9 2021 The present study provides evidence that BFM, TG, HDL, VLDL, atherogenic index, ionized calcium levels and uric acid have a significant impact on serum leptin in patients with hypertension and obesity. Uric Acid 107-116 leptin Homo sapiens 152-158
35468514-10 2022 Moreover, compound 6c effectively reduced the urate accumulation in the kidney and simultaneously decreased inflammation by regulating the expression of the TLR4/IkappaBalpha/NF-kappaB signaling pathway. Uric Acid 46-51 toll-like receptor 4 Mus musculus 157-161
34394285-0 2021 Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials. Uric Acid 0-9 insulin Homo sapiens 28-35
34394285-1 2021 Objectives: This meta-analysis aimed to investigate whether uric acid lowering treatment can improve beta-cell function and insulin sensitivity. Uric Acid 60-69 insulin Homo sapiens 124-131
34394285-8 2021 Conclusion: Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-beta and serum lipids. Uric Acid 12-21 insulin Homo sapiens 55-62
34308244-2 2021 The uric acid serum level was identified as an important biochemical marker which can predict preeclampsia, a type of PIH. Uric Acid 4-13 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 118-121
35314903-12 2022 Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells. Uric Acid 42-44 interleukin 1 beta Homo sapiens 114-118
35314903-12 2022 Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells. Uric Acid 42-44 interleukin 6 Homo sapiens 120-124
35314903-12 2022 Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells. Uric Acid 42-44 transforming growth factor alpha Homo sapiens 130-138
34376951-4 2021 Humans have lost the ability to metabolize uric acid as the "uricase" gene is suppressed. Uric Acid 43-52 urate oxidase (pseudogene) Homo sapiens 61-69
35219019-5 2022 Based on the machine learning algorithms, we successfully distinguished six antioxidants (ascorbic acid, glutathione, L-cysteine, dithiothreitol, uric acid, and dopamine) with the same concentration by either one kind of Fe-N-C SANs or three kinds of different Fe-N-C SANs. Uric Acid 146-155 USH1 protein network component sans Homo sapiens 228-232
35623171-2 2022 Hydralazine is an antihypertensive agent and may act as a xanthine oxidase (XO) inhibitor to reduce uric acid levels in a mouse renal injury model. Uric Acid 100-109 xanthine dehydrogenase Mus musculus 58-74
35397324-5 2022 The UOx-catalyzed oxidation of UA yielded H2O2, releasing the single-strand deoxyribonucleic acid (ssDNA) from the nanoceria/ssDNA complex. Uric Acid 31-33 urate oxidase (pseudogene) Homo sapiens 4-7
35229198-10 2022 In patients with eGFR >= 70 mL/min/1.73 m2, the rate of serum urate lowering was higher in those treated with benzbromarone than in those treated with febuxostat. Uric Acid 62-67 epidermal growth factor receptor Homo sapiens 17-21
35303071-0 2022 Soluble uric acid inhibits beta2 integrin-mediated neutrophil recruitment in innate immunity. Uric Acid 8-17 ATPase H+ transporting V0 subunit a2 Homo sapiens 27-32
35219019-5 2022 Based on the machine learning algorithms, we successfully distinguished six antioxidants (ascorbic acid, glutathione, L-cysteine, dithiothreitol, uric acid, and dopamine) with the same concentration by either one kind of Fe-N-C SANs or three kinds of different Fe-N-C SANs. Uric Acid 146-155 USH1 protein network component sans Homo sapiens 268-272
35574903-0 2022 Serum uric acid lowering mediated by glucagon-like peptide-1 receptor agonists: Emerging considerations. Uric Acid 6-15 glucagon like peptide 1 receptor Homo sapiens 37-69
35623880-6 2022 RESULTS: Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ~14% and ~17%, respectively. Uric Acid 117-122 citron rho-interacting serine/threonine kinase Homo sapiens 66-69
35623880-6 2022 RESULTS: Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ~14% and ~17%, respectively. Uric Acid 243-248 citron rho-interacting serine/threonine kinase Homo sapiens 66-69
35623880-6 2022 RESULTS: Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ~14% and ~17%, respectively. Uric Acid 243-248 citron rho-interacting serine/threonine kinase Homo sapiens 209-212
35633389-7 2022 After adjusting for multiple testing, there was a statistically significant positive association between urate lowering allele at SLC2A9 and hypertension, and negative association between urate raising allele at ABCG2 and hypertension (OR 1.17 and OR 0.86, respectively). Uric Acid 105-110 solute carrier family 2 member 9 Homo sapiens 130-136
35633389-7 2022 After adjusting for multiple testing, there was a statistically significant positive association between urate lowering allele at SLC2A9 and hypertension, and negative association between urate raising allele at ABCG2 and hypertension (OR 1.17 and OR 0.86, respectively). Uric Acid 188-193 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 212-217
35633389-9 2022 High eGFR associated with urate raising allele at rs2231142 (beta = 1.38). Uric Acid 26-31 epidermal growth factor receptor Homo sapiens 5-9
35037044-9 2022 Plasma ANGPTL2 concentrations were positively associated with >80% and 100% higher risk of all-cause mortality and cancer mortality, respectively, after adjustment for gender, smoking, alcohol consumption, walking time, sleep duration, caloric intake, medical status, disease history, BMI, and triglyceride, creatinine, uric acid, and high sensitivity C-reactive protein levels. Uric Acid 320-329 angiopoietin like 2 Homo sapiens 7-14
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 19-22 myeloid differentiation primary response gene 88 Mus musculus 123-128
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 19-22 interleukin 1 alpha Mus musculus 179-186
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 19-22 toll like receptor 4 Homo sapiens 276-280
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 19-22 interleukin 1 alpha Homo sapiens 302-309
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 158-161 myeloid differentiation primary response gene 88 Mus musculus 123-128
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 158-161 interleukin 1 alpha Mus musculus 179-186
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 158-161 toll like receptor 4 Homo sapiens 276-280
35616672-5 2022 Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta. Uric Acid 158-161 interleukin 1 alpha Homo sapiens 302-309
35592731-16 2022 TG, CHO, LDL and UA could serve as risk factors of MetS in psoriatic patients. Uric Acid 17-19 ETS variant transcription factor 3 Homo sapiens 51-55
35183688-9 2022 Furthermore, the variant rs751141, which was linked with a lower hydrolase activity of sEH, was significantly associated with metabolic traits, including blood levels of triglycerides, creatinine, and urate. Uric Acid 201-206 epoxide hydrolase 2 Homo sapiens 87-90
34989247-8 2022 We propose that sample tubes containing NaF-EDTA-citrate be used for the measurement of uric acid in patients administered rasburicase. Uric Acid 88-97 C-X-C motif chemokine ligand 8 Homo sapiens 40-43
35591906-1 2022 Aim: The aim of this study was to investigate the association between serum uric acid (SUA) levels and four insulin resistance surrogates in patients with type 2 diabetes (T2DM). Uric Acid 76-85 insulin Homo sapiens 108-115
35537999-8 2022 When albumin is combined with other risk factors, such as uric acid or C-reactive protein, the prognostic value is enhanced. Uric Acid 58-67 albumin Homo sapiens 5-12
35503137-0 2022 Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin. Uric Acid 50-59 solute carrier family 5 member 2 Homo sapiens 28-34
35505381-1 2022 BACKGROUND: The ABCG2, SLC22A12, and ALPK1 genes have been strongly associated with dysfunction of urate metabolism in patients with gout, but it is unknown how these transporters are expressed in patients with acute or chronic gout. Uric Acid 99-104 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 16-21
35505381-1 2022 BACKGROUND: The ABCG2, SLC22A12, and ALPK1 genes have been strongly associated with dysfunction of urate metabolism in patients with gout, but it is unknown how these transporters are expressed in patients with acute or chronic gout. Uric Acid 99-104 solute carrier family 22 member 12 Homo sapiens 23-31
35505381-1 2022 BACKGROUND: The ABCG2, SLC22A12, and ALPK1 genes have been strongly associated with dysfunction of urate metabolism in patients with gout, but it is unknown how these transporters are expressed in patients with acute or chronic gout. Uric Acid 99-104 alpha kinase 1 Homo sapiens 37-42
34989646-0 2022 A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio. Uric Acid 72-81 albumin Homo sapiens 82-89
35322793-1 2022 Background and objectives: Sodium glucose transporter 2 (SGLT2)-inhibitor-induced uric acid lowering may contribute to kidney protective effects of the drug-class in people with type 2 diabetes. Uric Acid 82-91 solute carrier family 5 member 2 Homo sapiens 27-55
35322793-2 2022 This study investigates mechanisms of plasma uric acid lowering by SGLT2-inhibitors in people with type 2 diabetes with a focus on urate transporter (URAT)1. Uric Acid 45-54 solute carrier family 5 member 2 Homo sapiens 67-72
35322793-2 2022 This study investigates mechanisms of plasma uric acid lowering by SGLT2-inhibitors in people with type 2 diabetes with a focus on urate transporter (URAT)1. Uric Acid 45-54 solute carrier family 22 member 12 Homo sapiens 131-156
35001416-0 2022 Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue. Uric Acid 15-24 insulin Homo sapiens 57-64
35001416-1 2022 OBJECTIVE: Serum uric acid (SUA) has been associated with cardiometabolic conditions such as insulin resistance (IR) and visceral adipose tissue (VAT) accumulation. Uric Acid 17-26 insulin Homo sapiens 93-100
35322793-12 2022 Conclusion: In conclusion, SGLT2-inhibitors induce uric acid excretion, which is strongly linked to urinary glucose excretion and which is attenuated during concomitant pharmacological blockade of URAT1. Uric Acid 51-60 solute carrier family 5 member 2 Homo sapiens 27-32
35322793-1 2022 Background and objectives: Sodium glucose transporter 2 (SGLT2)-inhibitor-induced uric acid lowering may contribute to kidney protective effects of the drug-class in people with type 2 diabetes. Uric Acid 82-91 solute carrier family 5 member 2 Homo sapiens 57-62
35322793-12 2022 Conclusion: In conclusion, SGLT2-inhibitors induce uric acid excretion, which is strongly linked to urinary glucose excretion and which is attenuated during concomitant pharmacological blockade of URAT1. Uric Acid 51-60 solute carrier family 22 member 12 Homo sapiens 197-202
35246462-0 2022 E4BP4 regulates hepatic SLC2A9 and uric acid disposition in mice. Uric Acid 35-44 nuclear factor, interleukin 3, regulated Mus musculus 0-5
35490380-7 2022 In contrast, urate was the only metabolite significantly decreased in the plasma and elevated in the urine, consistent with an effect on renal reuptake by URAT1. Uric Acid 13-18 solute carrier family 22 member 12 Homo sapiens 155-160
35536083-1 2022 BACKGROUND: Abnormal A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2 (ADAMTS2) and V-set and immunoglobulin domain-containing 4 (VSIG4) were explored in serum of heart failure (HF) patients and its association with C-reactive protein (CRP), uric acid (UA), and homocysteine (HCY) indexes was manifested. Uric Acid 258-267 V-set and immunoglobulin domain containing 4 Homo sapiens 100-144
35536083-1 2022 BACKGROUND: Abnormal A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2 (ADAMTS2) and V-set and immunoglobulin domain-containing 4 (VSIG4) were explored in serum of heart failure (HF) patients and its association with C-reactive protein (CRP), uric acid (UA), and homocysteine (HCY) indexes was manifested. Uric Acid 258-267 V-set and immunoglobulin domain containing 4 Homo sapiens 146-151
35536083-1 2022 BACKGROUND: Abnormal A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2 (ADAMTS2) and V-set and immunoglobulin domain-containing 4 (VSIG4) were explored in serum of heart failure (HF) patients and its association with C-reactive protein (CRP), uric acid (UA), and homocysteine (HCY) indexes was manifested. Uric Acid 269-271 V-set and immunoglobulin domain containing 4 Homo sapiens 100-144
35536083-1 2022 BACKGROUND: Abnormal A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2 (ADAMTS2) and V-set and immunoglobulin domain-containing 4 (VSIG4) were explored in serum of heart failure (HF) patients and its association with C-reactive protein (CRP), uric acid (UA), and homocysteine (HCY) indexes was manifested. Uric Acid 269-271 V-set and immunoglobulin domain containing 4 Homo sapiens 146-151
35246462-1 2022 SLC2A9 is a voltage-driven transporter that mediates cellular uptake and efflux of various substrates such as uric acid. Uric Acid 110-119 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 0-6
35246462-4 2022 Transporting activity of SLC2A9 was assessed using uric acid as a prototypical substrate. Uric Acid 51-60 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 25-31
35246462-7 2022 Furthermore, E4bp4 -/- mice showed increased hepatic uric acid but reduced uric acid in the plasma and urine. Uric Acid 54-63 nuclear factor, interleukin 3, regulated Mus musculus 13-18
35246462-7 2022 Furthermore, E4bp4 -/- mice showed increased hepatic uric acid but reduced uric acid in the plasma and urine. Uric Acid 76-85 nuclear factor, interleukin 3, regulated Mus musculus 13-18
35246462-12 2022 In conclusion, E4BP4 was identified as a novel regulator of SLC2A9 and uric acid homeostasis, which might facilitate new therapies for reducing uric acid in various conditions related to hyperuricemia. Uric Acid 71-80 nuclear factor, interleukin 3, regulated Mus musculus 15-20
35246462-12 2022 In conclusion, E4BP4 was identified as a novel regulator of SLC2A9 and uric acid homeostasis, which might facilitate new therapies for reducing uric acid in various conditions related to hyperuricemia. Uric Acid 144-153 nuclear factor, interleukin 3, regulated Mus musculus 15-20
35246462-13 2022 Significance Statement Our findings identify E4BP4 as a novel regulator of SLC2A9 and uric acid homeostasis, which might facilitate new therapies for reducing uric acid in various conditions related to hyperuricemia. Uric Acid 86-95 nuclear factor, interleukin 3, regulated Mus musculus 45-50
35246462-13 2022 Significance Statement Our findings identify E4BP4 as a novel regulator of SLC2A9 and uric acid homeostasis, which might facilitate new therapies for reducing uric acid in various conditions related to hyperuricemia. Uric Acid 159-168 nuclear factor, interleukin 3, regulated Mus musculus 45-50
35181437-4 2022 In this study, spontaneously elevated UA level induced hepatic IR and facilitated hepatic autophagy degradation in uricase knockout (Uox-/-) mice. Uric Acid 38-40 urate oxidase Mus musculus 133-136
35547005-9 2022 Furthermore, serum LCN-2 levels were positively correlated with hemoglobin A1c, systolic blood pressure, hypertension, CAP, and DN, as well as renal function factors including uric acid, creatinine, the estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio, respectively (P < 0.05), but negatively correlated with HDL-c (P < 0.05). Uric Acid 176-185 lipocalin 2 Homo sapiens 19-24
35501419-6 2022 An application of proteome-wide association studies to serum urate and gout implicated several proteins, including IL1RN, revealing the promise of the drug anakinra to treat acute gout flares. Uric Acid 61-66 interleukin 1 receptor antagonist Homo sapiens 115-120
35480874-0 2022 High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis. Uric Acid 14-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66
35630296-8 2022 The amount of xanthine oxidase, which catalyzes the formation of uric acid, decreased by 81%, and the transporters for excretion of urate were upregulated. Uric Acid 65-74 xanthine dehydrogenase Mus musculus 14-30
35630296-8 2022 The amount of xanthine oxidase, which catalyzes the formation of uric acid, decreased by 81%, and the transporters for excretion of urate were upregulated. Uric Acid 132-137 xanthine dehydrogenase Mus musculus 14-30
35450941-12 2022 PNP catabolised reactions were evidenced by changes in related metabolites, especially decreased levels of inosine and increased levels of uric acid. Uric Acid 139-148 purine nucleoside phosphorylase Homo sapiens 0-3
35460727-9 2022 Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels. Uric Acid 10-19 interferon gamma Homo sapiens 90-99
35460727-9 2022 Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels. Uric Acid 10-19 interleukin 17A Homo sapiens 101-107
35460727-9 2022 Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels. Uric Acid 10-19 interleukin 1 alpha Homo sapiens 109-117
35460727-9 2022 Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels. Uric Acid 10-19 C-X-C motif chemokine ligand 8 Homo sapiens 123-127
35462936-0 2022 (-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-kappaB Signaling Pathway. Uric Acid 28-44 NLR family pyrin domain containing 3 Homo sapiens 94-99
35495677-1 2022 Uricase catalyzes the conversion of uric acid into allantoin with concomitant reduction of molecular oxygen to hydrogen peroxide. Uric Acid 36-45 urate oxidase (pseudogene) Homo sapiens 0-7
35462902-0 2022 OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Uric Acid 31-36 solute carrier family 22 member 13 Homo sapiens 0-5
35416295-7 2022 RAC1 polymorphisms were associated with biochemical parameters in diabetics: rs7784465 (P=0.015) and rs836478 (P=0.028) with increased glycated hemoglobin, rs836478 (P=0.005) with increased fasting blood glucose, oxidized glutathione (P=0.012), and uric acid (P=0.034). Uric Acid 249-258 Rac family small GTPase 1 Homo sapiens 0-4
35240056-5 2022 For instance, deletion of PDZK1, which encodes a urate transporter scaffold protein, decreased serum urate levels, while deletion of RHD, which encodes the Rhesus blood group D antigen, associated with hematological traits. Uric Acid 101-106 PDZ domain containing 1 Homo sapiens 26-31
35462902-9 2022 Accordingly, OAT10 can be a novel potential molecular target for urate-lowering therapy. Uric Acid 65-70 solute carrier family 22 member 13 Homo sapiens 13-18
35462902-0 2022 OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Uric Acid 31-36 solute carrier family 22 member 13 Homo sapiens 6-14
35462936-0 2022 (-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-kappaB Signaling Pathway. Uric Acid 28-44 nuclear factor kappa B subunit 1 Homo sapiens 121-130
35462902-2 2022 OAT10 is a urate transporter; however, its physiological role in urate handling remains unclear. Uric Acid 65-70 solute carrier family 22 member 13 Homo sapiens 0-5
35462936-8 2022 Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis. Uric Acid 70-73 NLR family pyrin domain containing 3 Homo sapiens 119-124
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 44-49 solute carrier family 22 member 13 Homo sapiens 21-26
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 129-148
35462936-8 2022 Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis. Uric Acid 70-73 nuclear factor kappa B subunit 1 Homo sapiens 146-155
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 44-49 solute carrier family 22 member 12 Homo sapiens 150-155
35381951-6 2022 Levels of mda homolog FAM214A were elevated in inflammatory M1- and reduced in anti-inflammatory M2-differentiated mouse bone marrow macrophages, and influenced intracellular uric acid levels in human HepG2 transformed hepatocytes. Uric Acid 175-184 family with sequence similarity 214, member A Mus musculus 22-29
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 101-106 solute carrier family 22 member 13 Homo sapiens 21-26
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 101-106 solute carrier family 22 member 12 Homo sapiens 129-148
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 101-106 solute carrier family 22 member 12 Homo sapiens 150-155
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 202-207 solute carrier family 22 member 13 Homo sapiens 21-26
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 202-207 solute carrier family 22 member 12 Homo sapiens 129-148
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 202-207 solute carrier family 22 member 12 Homo sapiens 150-155
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 283-288 solute carrier family 22 member 13 Homo sapiens 21-26
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 283-288 solute carrier family 22 member 12 Homo sapiens 129-148
35462902-3 2022 We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. Uric Acid 283-288 solute carrier family 22 member 12 Homo sapiens 150-155
35462902-6 2022 Clinico-genetic analyses revealed that carriers with the dysfunctional OAT10 variant exhibited significantly lower serum urate levels and higher FEUA values than the non-carriers, indicating that dysfunction of OAT10 increases renal urate excretion. Uric Acid 121-126 solute carrier family 22 member 13 Homo sapiens 71-76
35462902-6 2022 Clinico-genetic analyses revealed that carriers with the dysfunctional OAT10 variant exhibited significantly lower serum urate levels and higher FEUA values than the non-carriers, indicating that dysfunction of OAT10 increases renal urate excretion. Uric Acid 233-238 solute carrier family 22 member 13 Homo sapiens 71-76
35462902-6 2022 Clinico-genetic analyses revealed that carriers with the dysfunctional OAT10 variant exhibited significantly lower serum urate levels and higher FEUA values than the non-carriers, indicating that dysfunction of OAT10 increases renal urate excretion. Uric Acid 233-238 solute carrier family 22 member 13 Homo sapiens 211-216
35462902-7 2022 Given the results of functional assays and immunohistochemical analysis demonstrating the expression of human OAT10 in the apical side of renal proximal tubular cells, our data indicate that OAT10 is involved in the renal urate reabsorption in renal proximal tubules from urine. Uric Acid 222-227 solute carrier family 22 member 13 Homo sapiens 191-196
35464445-2 2022 Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 197-245
35464445-2 2022 Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 247-252
35464445-2 2022 Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release. Uric Acid 66-82 interleukin 1 alpha Homo sapiens 316-324
35381951-7 2022 In conclusion, mda/FAM214A acts in a conserved manner to regulate purine metabolism, promotes disease driven by hyperuricemia and associated tissue inflammation, and provides a potential novel target for uric acid-driven pathologies. Uric Acid 204-213 family with sequence similarity 214 member A Homo sapiens 19-26
35384008-0 2022 The effect of Glucagon-like peptide-1 receptor agonists on serum uric acid concentration: A systematic review and meta-analysis. Uric Acid 65-74 glucagon like peptide 1 receptor Homo sapiens 14-46
35351833-5 2022 The log-klotho level was negatively correlated with the uric acid level (r = -0.154; p < 0.0001). Uric Acid 56-65 klotho Homo sapiens 8-14
35368226-0 2022 Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Uric Acid 23-39 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 0-5
35368226-0 2022 Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Uric Acid 23-39 NLR family, pyrin domain containing 3 Mus musculus 62-67
35368226-0 2022 Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Uric Acid 126-131 potassium voltage-gated channel, shaker-related subfamily, member 5 Mus musculus 0-5
35239453-12 2022 ZEB2 expression was elevated in MSU-administrated THP-1 cells and GA mice. Uric Acid 32-35 zinc finger E-box binding homeobox 2 Homo sapiens 0-4
35239453-13 2022 ZEB2 downregulation reserved the inhibitory effect of miRNA-142-3p deficiency on inflammatory response in MSU-treated THP-1 cells. Uric Acid 106-109 zinc finger E-box binding homeobox 2 Homo sapiens 0-4
35239453-14 2022 In addition, miRNA-142-3p activated NF-kappaB signaling by binding with ZEB2 in THP-1 cells upon MSU stimulation. Uric Acid 97-100 nuclear factor kappa B subunit 1 Homo sapiens 36-45
35239453-14 2022 In addition, miRNA-142-3p activated NF-kappaB signaling by binding with ZEB2 in THP-1 cells upon MSU stimulation. Uric Acid 97-100 zinc finger E-box binding homeobox 2 Homo sapiens 72-76
35365700-0 2022 Association between glucokinase regulator gene polymorphisms and serum uric acid levels in Taiwanese adolescents. Uric Acid 71-80 glucokinase regulator Homo sapiens 20-41
35365700-7 2022 Logistic and linear regression analyses explored the role of GCKR in abnormal uric acid (UA) levels. Uric Acid 89-91 glucokinase regulator Homo sapiens 61-65
35435033-1 2022 OBJECTIVE: Body mass index (BMI), uric acid, diabetes mellitus, and hypertension are risk factors for reduced kidney function and are associated with fetuin-A levels, but their causal pathways remain unclear. Uric Acid 34-43 alpha 2-HS glycoprotein Homo sapiens 150-158
35435033-3 2022 METHODS: A repeated cross-sectional design was used to assess causal pathway effects of fetuin-A on the estimated glomerular filtration rate (eGFR), which is mediated through BMI, uric acid, diabetes mellitus, and hypertension. Uric Acid 180-189 alpha 2-HS glycoprotein Homo sapiens 88-96
35435033-8 2022 CONCLUSIONS: Our study revealed a possible role of fetuin-A in the etiology of declining renal function through mediating body mass index, uric acid, diabetes mellitus, and hypertension via complex causal pathways. Uric Acid 139-148 alpha 2-HS glycoprotein Homo sapiens 51-59
35351833-6 2022 After adjustment for potential covariates, each one-unit increase in uric acid was significantly associated with a decrease in the log-klotho level (adjusted beta = -0.028; p < 0.0001). Uric Acid 69-78 klotho Homo sapiens 135-141
35351833-8 2022 We found a significant inverse association between serum uric acid and serum klotho levels in the general population, that is, an increase in serum uric acid levels was associated with a decrease in klotho levels. Uric Acid 57-66 klotho Homo sapiens 77-83
35351833-8 2022 We found a significant inverse association between serum uric acid and serum klotho levels in the general population, that is, an increase in serum uric acid levels was associated with a decrease in klotho levels. Uric Acid 57-66 klotho Homo sapiens 199-205
35351833-8 2022 We found a significant inverse association between serum uric acid and serum klotho levels in the general population, that is, an increase in serum uric acid levels was associated with a decrease in klotho levels. Uric Acid 148-157 klotho Homo sapiens 77-83
35356803-1 2022 Background and Aims: There are two types of serum uric acid-lowering agents, the xanthine oxidoreductase (XO) inhibitor and non-XO inhibitor. Uric Acid 50-59 xanthine dehydrogenase Homo sapiens 81-104
35227382-1 2022 Carbon dots without heteroatoms-doping and surface modifications were designed to be a novel chemosensing strategy on the quantitative detection of uric acid (UA) with the aid of uricase-induced enzymatic reaction and Fenton reaction. Uric Acid 148-157 urate oxidase (pseudogene) Homo sapiens 179-186
35227382-1 2022 Carbon dots without heteroatoms-doping and surface modifications were designed to be a novel chemosensing strategy on the quantitative detection of uric acid (UA) with the aid of uricase-induced enzymatic reaction and Fenton reaction. Uric Acid 159-161 urate oxidase (pseudogene) Homo sapiens 179-186
35406626-1 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. Uric Acid 160-169 solute carrier family 22 member 6 Homo sapiens 4-8
35406626-1 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. Uric Acid 160-169 solute carrier family 22 member 6 Homo sapiens 10-17
35406626-1 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. Uric Acid 160-169 solute carrier family 22 member 8 Homo sapiens 23-27
35406626-1 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. Uric Acid 160-169 solute carrier family 22 member 8 Homo sapiens 29-36
35342538-0 2022 Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials. Uric Acid 69-74 solute carrier family 5 member 2 Homo sapiens 10-40
35342538-0 2022 Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials. Uric Acid 69-74 solute carrier family 5 member 2 Homo sapiens 42-47
35342538-1 2022 Objectives: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been found to reduce serum urate in patients with type 2 diabetes mellitus. Uric Acid 94-99 solute carrier family 5 member 2 Homo sapiens 12-42
35342538-1 2022 Objectives: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been found to reduce serum urate in patients with type 2 diabetes mellitus. Uric Acid 94-99 solute carrier family 5 member 2 Homo sapiens 44-49
35342538-2 2022 To evaluate if this effect applies to both patients with and without diabetes, we conducted a systematic review and meta-analysis of SGLT2 inhibitors on serum urate levels in this population. Uric Acid 159-164 solute carrier family 5 member 2 Homo sapiens 133-138
35342538-3 2022 Methods: Four electronic databases (PubMed, Embase, Cochrane and SCOPUS) were searched on 25 September 2021 for articles published from 1 January 2000 up to 25 September 2021, for studies that examined the effect of SGLT2 inhibitors on serum urate in study subjects. Uric Acid 242-247 solute carrier family 5 member 2 Homo sapiens 216-221
35342538-8 2022 However, in type 2 diabetes mellitus (T2DM) patients with chronic kidney disease, the reduction in serum urate with SGLT2 inhibitors became insignificant (95% CI: -22.17 to 5.94, p < 0.01). Uric Acid 105-110 solute carrier family 5 member 2 Homo sapiens 116-121
35342538-9 2022 Conclusion: This study demonstrated that SGLT2 inhibitors are beneficial in reducing serum urate in patients with and without diabetes. Uric Acid 91-96 solute carrier family 5 member 2 Homo sapiens 41-46
35328045-5 2022 Regional plot association analysis of the GCKR gene region further revealed genome-wide significant associations between GCKR variants and serum total and low-density lipoprotein cholesterol; triglyceride, uric acid, creatinine, aspartate aminotransferase, gamma-Glutamyl transferase, albumin, and fasting plasma glucose levels; estimated glomerular filtration rate; leukocyte and platelet counts; microalbuminuria, and metabolic syndrome, with rs1260326 being the most common lead polymorphism. Uric Acid 206-215 glucokinase regulator Homo sapiens 42-46
35300582-12 2022 Triglyceride, uric acid, CRP, vitamin B12, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Uric Acid 132-141 C-reactive protein Homo sapiens 25-28
35300582-12 2022 Triglyceride, uric acid, CRP, vitamin B12, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Uric Acid 132-141 insulin Homo sapiens 79-86
35296708-0 2022 Natural antibodies and CRP drive anaphylatoxin production by urate crystals. Uric Acid 61-66 C-reactive protein Homo sapiens 23-26
35296708-3 2022 We previously found that the soluble pattern recognition molecule C-reactive protein (CRP) recognizes MSU crystals, while enhancing complement activation. Uric Acid 102-105 C-reactive protein Homo sapiens 66-84
35296708-3 2022 We previously found that the soluble pattern recognition molecule C-reactive protein (CRP) recognizes MSU crystals, while enhancing complement activation. Uric Acid 102-105 C-reactive protein Homo sapiens 86-89
35296708-9 2022 We show that IgM and CRP both activate the classical complement pathway on MSU crystals. Uric Acid 75-78 C-reactive protein Homo sapiens 21-24
35296708-11 2022 Notably, while CRP recognizes MSU crystals but not the related calcium pyrophosphate dihydrate (CPPD) crystals, natural IgM bound to both, suggesting common and distinct mechanisms of recognition of individual crystal types by complement activators. Uric Acid 30-33 C-reactive protein Homo sapiens 15-18
35328045-5 2022 Regional plot association analysis of the GCKR gene region further revealed genome-wide significant associations between GCKR variants and serum total and low-density lipoprotein cholesterol; triglyceride, uric acid, creatinine, aspartate aminotransferase, gamma-Glutamyl transferase, albumin, and fasting plasma glucose levels; estimated glomerular filtration rate; leukocyte and platelet counts; microalbuminuria, and metabolic syndrome, with rs1260326 being the most common lead polymorphism. Uric Acid 206-215 glucokinase regulator Homo sapiens 121-125
35316517-3 2022 Antidrug antibodies against biologic therapies, including uricase and PEGylated uricase, can lead to loss of urate-lowering response, increased risk of infusion reactions, and subsequent treatment failure. Uric Acid 109-114 urate oxidase (pseudogene) Homo sapiens 58-65
35264217-9 2022 Two additional SNP variants (rs2231142.GG of ABCG2 and rs11231463.GG of SLC22A9/OAT7) were selected based on their contributions to gout in the development cohort and their reported effects on renal urate handling. Uric Acid 199-204 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 45-50
35264217-9 2022 Two additional SNP variants (rs2231142.GG of ABCG2 and rs11231463.GG of SLC22A9/OAT7) were selected based on their contributions to gout in the development cohort and their reported effects on renal urate handling. Uric Acid 199-204 solute carrier family 22 member 9 Homo sapiens 72-79
35264217-9 2022 Two additional SNP variants (rs2231142.GG of ABCG2 and rs11231463.GG of SLC22A9/OAT7) were selected based on their contributions to gout in the development cohort and their reported effects on renal urate handling. Uric Acid 199-204 solute carrier family 22 member 9 Homo sapiens 80-84
35256513-7 2022 Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and lipopolysaccharide (LPS)-induced endotoxemia, which are dependent on caspase-1, respectively, show increased neutrophil infiltration and lethality in Rnh1 -/- mice compared with wild-type mice. Uric Acid 36-52 caspase 1 Mus musculus 152-161
35256513-7 2022 Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and lipopolysaccharide (LPS)-induced endotoxemia, which are dependent on caspase-1, respectively, show increased neutrophil infiltration and lethality in Rnh1 -/- mice compared with wild-type mice. Uric Acid 36-52 ribonuclease/angiogenin inhibitor 1 Mus musculus 233-237
35256513-7 2022 Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and lipopolysaccharide (LPS)-induced endotoxemia, which are dependent on caspase-1, respectively, show increased neutrophil infiltration and lethality in Rnh1 -/- mice compared with wild-type mice. Uric Acid 54-57 caspase 1 Mus musculus 152-161
35256513-7 2022 Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and lipopolysaccharide (LPS)-induced endotoxemia, which are dependent on caspase-1, respectively, show increased neutrophil infiltration and lethality in Rnh1 -/- mice compared with wild-type mice. Uric Acid 54-57 ribonuclease/angiogenin inhibitor 1 Mus musculus 233-237
35309342-6 2022 Inhibition of autophagy with 3-methyladenine (3-MA) and transfected with Beclin-1 siRNA prevented uric acid-induced upregulation of alpha-SMA, Collagen I and Collagen III in HK-2 cells. Uric Acid 98-107 beclin 1 Homo sapiens 73-81
35309342-6 2022 Inhibition of autophagy with 3-methyladenine (3-MA) and transfected with Beclin-1 siRNA prevented uric acid-induced upregulation of alpha-SMA, Collagen I and Collagen III in HK-2 cells. Uric Acid 98-107 actin alpha 1, skeletal muscle Homo sapiens 132-141
35309342-7 2022 Moreover, uric acid upregulated autophagy via promoting the p53 pathway. Uric Acid 10-19 tumor protein p53 Homo sapiens 60-63
35309342-10 2022 Stimulation with uric acid in HK-2 cells also resulted in NLRP3 inflammasome activation and pyroptotic cell death, however treatment with 3-MA prevented all these responses. Uric Acid 17-26 NLR family pyrin domain containing 3 Homo sapiens 58-63
35316517-3 2022 Antidrug antibodies against biologic therapies, including uricase and PEGylated uricase, can lead to loss of urate-lowering response, increased risk of infusion reactions, and subsequent treatment failure. Uric Acid 109-114 urate oxidase (pseudogene) Homo sapiens 80-87
35203284-0 2022 Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System. Uric Acid 71-80 solute carrier family 2 member 9 Homo sapiens 0-21
35273682-2 2022 METHODS: The sensor was constructed with the beta-CD-CuNCs-MWCNTs-nafion film and successfully used for the quantitative detection of 8-OhdG in the presence of biomolecules such as ascorbic acid (AA) and uric acid (UA). Uric Acid 204-213 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 45-52
35273682-2 2022 METHODS: The sensor was constructed with the beta-CD-CuNCs-MWCNTs-nafion film and successfully used for the quantitative detection of 8-OhdG in the presence of biomolecules such as ascorbic acid (AA) and uric acid (UA). Uric Acid 215-217 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 45-52
35224108-0 2022 Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis. Uric Acid 68-77 solute carrier family 5 member 2 Homo sapiens 11-41
35224108-2 2022 We conducted a quantitative analysis to assess the impact of SGLT2is on serum uric acid (SUA) in patients with T2DM. Uric Acid 78-87 solute carrier family 5 member 2 Homo sapiens 61-66
35153251-0 2022 Correlation between serum C-peptide-releasing effects and the risk of elevated uric acid in type 2 diabetes mellitus. Uric Acid 79-88 insulin Homo sapiens 26-35
35153251-1 2022 Our study aimed to investigate the C-peptide-releasing effect associated with the risk of elevated serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM). Uric Acid 105-114 insulin Homo sapiens 35-44
35203284-0 2022 Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System. Uric Acid 71-80 solute carrier family 2 member 9 Homo sapiens 23-28
35203284-3 2022 Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. Uric Acid 49-58 solute carrier family 2 member 9 Homo sapiens 0-21
35203284-3 2022 Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. Uric Acid 49-58 solute carrier family 2 member 9 Homo sapiens 23-28
35203284-10 2022 CONCLUSIONS: These findings demonstrate that the placenta efficiently maintains uric acid homeostasis, and that GLUT9 plays a key role in the placental uric acid transport system, at least in this murine model. Uric Acid 152-161 solute carrier family 2 (facilitated glucose transporter), member 9 Mus musculus 112-117
35139059-0 2022 High uric acid induced hippocampal mitochondrial dysfunction and cognitive impairment involving intramitochondrial NF-kappaB inhibitor alpha/nuclear factor-kappaB pathway. Uric Acid 5-14 NFKB inhibitor alpha Rattus norvegicus 115-140
35185617-0 2022 The Association Between Physical Activity and Insulin Level Under Different Levels of Lipid Indices and Serum Uric Acid. Uric Acid 110-119 insulin Homo sapiens 46-53
35139059-5 2022 Mechanistically, excess UA might trigger intramitochondrial NF-kappaB inhibitor alpha (IkappaBalpha)/nuclear factor-kappaB (NF-kappaB) pathway to downregulate the subunit III of COX (COXIII). Uric Acid 24-26 NFKB inhibitor alpha Rattus norvegicus 60-85
35139059-5 2022 Mechanistically, excess UA might trigger intramitochondrial NF-kappaB inhibitor alpha (IkappaBalpha)/nuclear factor-kappaB (NF-kappaB) pathway to downregulate the subunit III of COX (COXIII). Uric Acid 24-26 NFKB inhibitor alpha Rattus norvegicus 87-99
35152831-0 2022 Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process. Uric Acid 0-9 epidermal growth factor Homo sapiens 60-83
35152831-0 2022 Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process. Uric Acid 0-9 epidermal growth factor Homo sapiens 85-88
35152831-7 2022 The results showed that high concentration of UA (10 mg/dl) severely affected the biological activity of EGF. Uric Acid 46-48 epidermal growth factor Homo sapiens 105-108
35152831-8 2022 High concentration of UA suppressed the activity of EGF, and inhibited the biological effect of EGF on the HUVECs. Uric Acid 22-24 epidermal growth factor Homo sapiens 52-55
35152831-8 2022 High concentration of UA suppressed the activity of EGF, and inhibited the biological effect of EGF on the HUVECs. Uric Acid 22-24 epidermal growth factor Homo sapiens 96-99
35152831-9 2022 However, it is interesting that EGF-mediated intracellular signaling was significantly down-regulated in the H2O2-induced senescent HUVEC, and physiological concentration of UA could at least partially restore the EGF-mediated signaling. Uric Acid 174-176 epidermal growth factor Homo sapiens 32-35
35152831-9 2022 However, it is interesting that EGF-mediated intracellular signaling was significantly down-regulated in the H2O2-induced senescent HUVEC, and physiological concentration of UA could at least partially restore the EGF-mediated signaling. Uric Acid 174-176 epidermal growth factor Homo sapiens 214-217
35001553-5 2022 The results showed that low albumin and uric acid levels were the risk factors for type II respiratory failure in acute exacerbation of COPD patients, and the differences were statistically significant (albumin: SMD = -2.03, 95% CI: -2.81, -1.26; uric acid: SMD = -1.28, 95% CI: -1.41, -1.15). Uric Acid 40-49 albumin Homo sapiens 203-210
35150223-10 2022 The percent change in VAT1 and VAT2 was a significant predictor of change in 24 HU uric acid (respectively, R2: 0.14, beta: -0.03, p = 0.002 and R2: 0.13, beta: -0.03, p = 0.003). Uric Acid 83-92 vesicle amine transport 1 Homo sapiens 22-26
35150223-10 2022 The percent change in VAT1 and VAT2 was a significant predictor of change in 24 HU uric acid (respectively, R2: 0.14, beta: -0.03, p = 0.002 and R2: 0.13, beta: -0.03, p = 0.003). Uric Acid 83-92 solute carrier family 18 member A2 Homo sapiens 31-35
35001553-5 2022 The results showed that low albumin and uric acid levels were the risk factors for type II respiratory failure in acute exacerbation of COPD patients, and the differences were statistically significant (albumin: SMD = -2.03, 95% CI: -2.81, -1.26; uric acid: SMD = -1.28, 95% CI: -1.41, -1.15). Uric Acid 247-256 albumin Homo sapiens 28-35
35400961-5 2022 Materials and Methods: An in silico study was done by pharmacodynamic modeling of PIP in suppressing MSU-induced inflammation through disruption of the NLRP3 inflammasome. Uric Acid 101-104 NLR family, pyrin domain containing 3 Rattus norvegicus 152-157
34981522-3 2022 PSPLP inhibited the levels of cytokines (IL-1beta, IL-6, and TNF-alpha) in monosodium urate-induced RAW264.7 cells. Uric Acid 75-91 interleukin 1 alpha Mus musculus 41-49
34981522-3 2022 PSPLP inhibited the levels of cytokines (IL-1beta, IL-6, and TNF-alpha) in monosodium urate-induced RAW264.7 cells. Uric Acid 75-91 interleukin 6 Mus musculus 51-55
34981522-3 2022 PSPLP inhibited the levels of cytokines (IL-1beta, IL-6, and TNF-alpha) in monosodium urate-induced RAW264.7 cells. Uric Acid 75-91 tumor necrosis factor Mus musculus 61-70
35185008-0 2022 Development of a patient decision aid for the initiation of urate-lowering therapy in gout patients. Uric Acid 60-65 activation induced cytidine deaminase Homo sapiens 34-37
35185008-2 2022 This study describes the development of a decision aid (DA) that supports patients with gout and their physicians in a face-to-face clinical setting to (a) decide whether or not to (re)start urate-lowering therapy (ULT) and (b) agree on the preferred ULT. Uric Acid 191-196 activation induced cytidine deaminase Homo sapiens 51-54
35153751-4 2021 Meanwhile, PEC alleviated inflammation, fibrosis, and reduced adipokine FABP4 content in the kidneys of HN mice and uric acid-treated TCMK-1 cells. Uric Acid 116-125 fatty acid binding protein 4, adipocyte Mus musculus 72-77
35126949-14 2022 In the follow-up, 16 patients with CNI-related renal damage were found to be immune rejection before the adjustment of immunosuppression program, no complications such as immune rejection, myelosuppression, and infection occurred within 15 months after the adjustment of immunosuppression program, blood glucose increased in 3 patients within 2 years after operation, blood lipid increased in 1 patient, urea increased in 1 patient, and uric acid increased in 1 patient. Uric Acid 437-446 5'-nucleotidase, cytosolic IA Homo sapiens 35-38
35154099-0 2022 Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation. Uric Acid 67-83 glucagon Mus musculus 0-23
35154099-9 2022 In monosodium urate (MSU) crystal-induced peritonitis, an experimental model of gout, the recruitment of macrophages, especially M2 macrophages, was significantly suppressed in GLP-1R knockout mice compared to wild-type mice. Uric Acid 3-19 glucagon-like peptide 1 receptor Mus musculus 177-183
35154099-9 2022 In monosodium urate (MSU) crystal-induced peritonitis, an experimental model of gout, the recruitment of macrophages, especially M2 macrophages, was significantly suppressed in GLP-1R knockout mice compared to wild-type mice. Uric Acid 21-24 glucagon-like peptide 1 receptor Mus musculus 177-183
35154099-10 2022 In conclusion, our data suggests that GLP-1R plays a critical role in macrophage migration in MSU-induced inflammation. Uric Acid 94-97 glucagon-like peptide 1 receptor Mus musculus 38-44
35154100-0 2022 Purine-Induced IFN-gamma Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. Uric Acid 34-43 interferon gamma Homo sapiens 15-24
35154100-0 2022 Purine-Induced IFN-gamma Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. Uric Acid 34-43 xanthine dehydrogenase Homo sapiens 71-94
35154100-1 2022 Objective: Limiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout. Uric Acid 166-175 xanthine dehydrogenase Homo sapiens 71-74
35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. Uric Acid 45-47 xanthine dehydrogenase Homo sapiens 76-79
35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. Uric Acid 45-47 interferon gamma Homo sapiens 100-109
35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. Uric Acid 45-47 xanthine dehydrogenase Homo sapiens 232-235
35169393-4 2022 Results: Compared with the control group, the level values of serum c-peptide, sICAM-1, and IL-1beta were significantly higher in the case group (P < 0.001), with CSVD being the dependent variable, and age, smoking, uric acid, history of stroke, serum c-peptide, sICAM-1, and IL-1beta being the independent variables. Uric Acid 216-225 insulin Homo sapiens 68-77
35169393-4 2022 Results: Compared with the control group, the level values of serum c-peptide, sICAM-1, and IL-1beta were significantly higher in the case group (P < 0.001), with CSVD being the dependent variable, and age, smoking, uric acid, history of stroke, serum c-peptide, sICAM-1, and IL-1beta being the independent variables. Uric Acid 216-225 interleukin 1 alpha Homo sapiens 92-100
35276896-7 2022 Metabolomic analysis identified distinct metabolic profiles driven by allantoin (VIP score = 2.85, PS 2.3-fold higher), a catabolic product of uric acid. Uric Acid 143-152 vasoactive intestinal peptide Homo sapiens 81-84
35152667-14 2022 Conclusion: In chronic hepatitis C, reduced eGFR and body mass index are the risk factors for the development of hyperuricemia and a significant reduction in serum uric acid levels after DAA treatment can eradicate the virus. Uric Acid 164-173 epidermal growth factor receptor Homo sapiens 44-48
35063039-7 2022 We should pay attention to the genotoxicity of uric acid in terms of DNA damage to dGuo and dAdo sites mediated by sunlight. Uric Acid 47-56 ado Drosophila melanogaster 92-96
35022448-7 2022 ImmTOR inhibits the development of uricase-specific ADAs in a dose-dependent manner, thus enabling sustained enzyme activity and reduction in serum uric acid levels. Uric Acid 148-157 urate oxidase (pseudogene) Homo sapiens 35-42
35005767-1 2022 We report enzyme-powered upconversion-nanoparticle-functionalized Janus micromotors, which are prepared by immobilizing uricase asymmetrically onto the surface of silicon particles, to actively and rapidly detect uric acid. Uric Acid 213-222 urate oxidase (pseudogene) Homo sapiens 120-127
35005767-2 2022 The asymmetric distribution of uricase on silicon particles allows the Janus micromotors to display efficient motion in urine under the propulsion of biocatalytic decomposition of uric acid and simultaneously detect uric acid based on the luminescence quenching effect of the UCNPs modified on the other side of SiO2. Uric Acid 180-189 urate oxidase (pseudogene) Homo sapiens 31-38
35005767-2 2022 The asymmetric distribution of uricase on silicon particles allows the Janus micromotors to display efficient motion in urine under the propulsion of biocatalytic decomposition of uric acid and simultaneously detect uric acid based on the luminescence quenching effect of the UCNPs modified on the other side of SiO2. Uric Acid 216-225 urate oxidase (pseudogene) Homo sapiens 31-38
35055927-3 2022 Based on the above two patterns, atmospheric nitrogen or nitrogenous waste (e.g., uric acid, urea) is converted into ammonia, which in turn is incorporated into the organism via the glutamine synthetase and glutamate synthase pathways. Uric Acid 82-91 glutamate-ammonia ligase Homo sapiens 182-202
35079220-0 2022 Inverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses. Uric Acid 94-103 C-reactive protein Homo sapiens 50-68
35083262-0 2021 The Active Components of Sunflower (Helianthus annuus L.) Calathide and the Effects on Urate Nephropathy Based on COX-2/PGE2 Signaling Pathway and the Urate Transporter URAT1, ABCG2, and GLUT9. Uric Acid 87-92 cytochrome c oxidase II, mitochondrial Mus musculus 114-119
35087877-5 2021 In the hypertension non-treatment group, the associations between UA and BP including SBP, DBP were both an inverted U-shape. Uric Acid 66-68 selenium binding protein 1 Homo sapiens 86-89
35087877-5 2021 In the hypertension non-treatment group, the associations between UA and BP including SBP, DBP were both an inverted U-shape. Uric Acid 66-68 D-box binding PAR bZIP transcription factor Homo sapiens 91-94
35087877-12 2021 In the hypertension non-treatment group, the associations between UA and BP including SBP and DBP were both an inverted U-shape. Uric Acid 66-68 selenium binding protein 1 Homo sapiens 86-89
35087877-12 2021 In the hypertension non-treatment group, the associations between UA and BP including SBP and DBP were both an inverted U-shape. Uric Acid 66-68 D-box binding PAR bZIP transcription factor Homo sapiens 94-97
34985729-8 2022 Finally, intracellular ROS production was determined using fluorescent probes (DCFH-DA).High concentrations of UA either alone or combined with LPS increased the protein levels of GRP78 and CHOP. Uric Acid 111-113 heat shock protein family A (Hsp70) member 5 Homo sapiens 180-185
34985729-8 2022 Finally, intracellular ROS production was determined using fluorescent probes (DCFH-DA).High concentrations of UA either alone or combined with LPS increased the protein levels of GRP78 and CHOP. Uric Acid 111-113 DNA damage inducible transcript 3 Homo sapiens 190-194
34985729-11 2022 High concentrations of UA augmented LPS-stimulated IL-1beta transcript and protein levels as well as TNF-alpha protein levels in PBMC culture. Uric Acid 23-25 interleukin 1 alpha Homo sapiens 51-59
34985729-11 2022 High concentrations of UA augmented LPS-stimulated IL-1beta transcript and protein levels as well as TNF-alpha protein levels in PBMC culture. Uric Acid 23-25 tumor necrosis factor Homo sapiens 101-110
35062740-10 2022 Urate reduction correlated with higher Abs (R 0.552, p = 0.033). Uric Acid 0-5 DEAD-box helicase 41 Homo sapiens 39-42
35397151-1 2022 We aimed to evaluate the effects of the reduction in dietary crude protein (CP) on blood urea, uric acid, performance, immunity, and intestinal histology of broilers. Uric Acid 95-104 ceruloplasmin Gallus gallus 76-78
35154904-0 2022 Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-beta-activated kinase 1. Uric Acid 0-9 killer cell lectin-like receptor subfamily K, member 1 Mus musculus 58-63
35154904-0 2022 Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-beta-activated kinase 1. Uric Acid 0-9 mitogen-activated protein kinase kinase kinase 7 Mus musculus 119-146
35154904-3 2022 Here we report that xanthine oxidoreductase (XOR), a rate-limiting enzyme that produces uric acid in the purine catabolism pathway, promotes DNA damage-induced MICA/B expression. Uric Acid 88-97 xanthine dehydrogenase Mus musculus 20-43
35154904-3 2022 Here we report that xanthine oxidoreductase (XOR), a rate-limiting enzyme that produces uric acid in the purine catabolism pathway, promotes DNA damage-induced MICA/B expression. Uric Acid 88-97 xanthine dehydrogenase Mus musculus 45-48
35154904-4 2022 Inhibition of the ATM-Chk pathway blocks genotoxic drug-induced uric acid production, TGF-beta-activated kinase 1 (TAK1) activation, ERK phosphorylation, and MICA/B expression. Uric Acid 64-73 ataxia telangiectasia mutated Mus musculus 18-21
35154904-4 2022 Inhibition of the ATM-Chk pathway blocks genotoxic drug-induced uric acid production, TGF-beta-activated kinase 1 (TAK1) activation, ERK phosphorylation, and MICA/B expression. Uric Acid 64-73 megakaryocyte-associated tyrosine kinase Mus musculus 22-25
35154904-5 2022 Inhibition of uric acid production by the XOR inhibitor allopurinol blocks DNA damage-induced TAK1 activation and MICA/B expression in genotoxic drug-treated cells. Uric Acid 14-23 xanthine dehydrogenase Mus musculus 42-45
35154904-6 2022 Exogenous uric acid activates TAK1, NF-kappaB, and the MAP kinase pathway. Uric Acid 10-19 mitogen-activated protein kinase kinase kinase 7 Mus musculus 30-34
35154904-7 2022 TAK1 inhibition blocks gemcitabine- and uric acid-induced MAP kinase activation and MICA/B expression. Uric Acid 40-49 mitogen-activated protein kinase kinase kinase 7 Mus musculus 0-4
35154904-10 2022 Our study suggests that uric acid accumulation plays an important role in activating TAK1, inducing DNA damage-induced MICA/B expression, and enhancing antitumor immunity. Uric Acid 24-33 mitogen-activated protein kinase kinase kinase 7 Mus musculus 85-89
35397151-5 2022 Uric acid decreased and urea increased with the reduction of CP (p < 0.05). Uric Acid 0-9 ceruloplasmin Gallus gallus 61-63
35047042-14 2022 UA significantly suppressed Min6 cell growth, promoted cell apoptosis, and enhanced caspase-3 activity; however, AS-IV abolished these effects in a dose-dependent manner. Uric Acid 0-2 caspase 3 Mus musculus 84-93
34965184-7 2022 The elevated Gait score promoted synovitis score and activated myeloperoxidase (MPO) observed in MSU crystals-treated mice were significantly reversed by colchicine and S14G-HNG. Uric Acid 97-100 myeloperoxidase Mus musculus 63-78
35047042-16 2022 AS-IV significantly increased phosphorylated (p)-AKT expression and the ratio of p-AKT/AKT in Min6 cells exposed to UA. Uric Acid 116-118 thymoma viral proto-oncogene 1 Mus musculus 49-52
35047042-16 2022 AS-IV significantly increased phosphorylated (p)-AKT expression and the ratio of p-AKT/AKT in Min6 cells exposed to UA. Uric Acid 116-118 thymoma viral proto-oncogene 1 Mus musculus 83-86
35047042-16 2022 AS-IV significantly increased phosphorylated (p)-AKT expression and the ratio of p-AKT/AKT in Min6 cells exposed to UA. Uric Acid 116-118 thymoma viral proto-oncogene 1 Mus musculus 87-90
34965184-9 2022 The increased mitochondrial reactive oxygen species (ROS) and Malondialdehyde (MDA) levels, upregulated NADPH oxidase-4 (NOX-4), activated NLRP3 inflammasome, and elevated production of inflammatory factors in MSU crystals-treated BMDMs were dramatically reversed by S14G-HNG, accompanied by the upregulation of sirtuin type-1 (SIRT1). Uric Acid 210-213 NADPH oxidase 4 Mus musculus 104-119
34965184-7 2022 The elevated Gait score promoted synovitis score and activated myeloperoxidase (MPO) observed in MSU crystals-treated mice were significantly reversed by colchicine and S14G-HNG. Uric Acid 97-100 myeloperoxidase Mus musculus 80-83
34965184-7 2022 The elevated Gait score promoted synovitis score and activated myeloperoxidase (MPO) observed in MSU crystals-treated mice were significantly reversed by colchicine and S14G-HNG. Uric Acid 97-100 neurogranin Homo sapiens 174-177
34965184-10 2022 Lastly, the protective effects of S14G-HNG against MSU crystals-induced NLRP3 inflammasome activation were significantly abolished by the knockdown of SIRT1. Uric Acid 51-54 neurogranin Homo sapiens 39-42
34965184-10 2022 Lastly, the protective effects of S14G-HNG against MSU crystals-induced NLRP3 inflammasome activation were significantly abolished by the knockdown of SIRT1. Uric Acid 51-54 NLR family, pyrin domain containing 3 Mus musculus 72-77
34965184-10 2022 Lastly, the protective effects of S14G-HNG against MSU crystals-induced NLRP3 inflammasome activation were significantly abolished by the knockdown of SIRT1. Uric Acid 51-54 sirtuin 1 Mus musculus 151-156
35001880-3 2022 RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. Uric Acid 15-24 insulin Homo sapiens 156-163
34975301-8 2022 Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. Uric Acid 67-76 fatty acid binding protein 3 Homo sapiens 22-27
35139514-7 2022 Spearman correlation analysis of related indicators revealed that serum Cys-C was positively correlated with creatinine, uric acid, and FAZ circularity (P<0.05). Uric Acid 121-130 cystatin C Homo sapiens 72-77
35173546-5 2022 CD137-positive lymphatic vessels were involved in the development process of IgA nephropathy and positively correlated with serum creatinine, serum urea nitrogen, serum uric acid, and urinary 24 h total protein. Uric Acid 169-178 TNF receptor superfamily member 9 Homo sapiens 0-5
35173546-5 2022 CD137-positive lymphatic vessels were involved in the development process of IgA nephropathy and positively correlated with serum creatinine, serum urea nitrogen, serum uric acid, and urinary 24 h total protein. Uric Acid 169-178 CD79a molecule Homo sapiens 77-80