PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Oxacillin	204-213	TEM beta-lactamase	Klebsiella pneumoniae	21-24
20599331-3	2011	Our analysis showed that the penicillin-hydrolyzing BlaZ alone was responsible for the hydrolysis of both methicillin and oxacillin.	Oxacillin	122-131	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	52-56
21106176-3	2010	Oxacillin remains active against these strains, but hospital associated staphylococci and more recently community acquired staphylococci have developed crossed resistance between methicillin (MRSA), oxacillin and other beta-lactams by production of a penicillin binding protein (PBP) with low affinity for beta-lactams, PBP2a.	Oxacillin	0-9	AT695_RS11765	Staphylococcus aureus	251-277
21209682-3	2011	Instrumental improvements are detailed and constants for the model bovine serum albumin (BSA):oxacillin bioassay are presented.	Oxacillin	94-103	albumin	Homo sapiens	74-87
20483504-0	2010	Oxacillin-susceptible MRSA, the emerging MRSA clone in the UK?	Oxacillin	0-9	solute carrier family 9 member A6	Homo sapiens	22-26
20483504-0	2010	Oxacillin-susceptible MRSA, the emerging MRSA clone in the UK?	Oxacillin	0-9	solute carrier family 9 member A6	Homo sapiens	41-45
21106176-3	2010	Oxacillin remains active against these strains, but hospital associated staphylococci and more recently community acquired staphylococci have developed crossed resistance between methicillin (MRSA), oxacillin and other beta-lactams by production of a penicillin binding protein (PBP) with low affinity for beta-lactams, PBP2a.	Oxacillin	0-9	AT695_RS11765	Staphylococcus aureus	279-282
21106176-3	2010	Oxacillin remains active against these strains, but hospital associated staphylococci and more recently community acquired staphylococci have developed crossed resistance between methicillin (MRSA), oxacillin and other beta-lactams by production of a penicillin binding protein (PBP) with low affinity for beta-lactams, PBP2a.	Oxacillin	199-208	AT695_RS11765	Staphylococcus aureus	251-277
21106176-3	2010	Oxacillin remains active against these strains, but hospital associated staphylococci and more recently community acquired staphylococci have developed crossed resistance between methicillin (MRSA), oxacillin and other beta-lactams by production of a penicillin binding protein (PBP) with low affinity for beta-lactams, PBP2a.	Oxacillin	199-208	AT695_RS11765	Staphylococcus aureus	279-282
18495583-9	2008	mecA, ermA, and ermC genes are among the predominant genetic determinants for the resistance to oxacillin and erythromycin in S. aureus isolates in Guangzhou.	Oxacillin	96-105	rRNA methylase Erm(A)	Staphylococcus aureus	6-10
20516078-2	2010	MRSA is resistant to oxacillin because of the presence of penicillin-binding protein 2a (PBP2a), which allows peptidoglycan synthesis to continue after oxacillin-mediated acylation of native PBPs.	Oxacillin	21-30	AT695_RS11765	Staphylococcus aureus	58-84
20516078-2	2010	MRSA is resistant to oxacillin because of the presence of penicillin-binding protein 2a (PBP2a), which allows peptidoglycan synthesis to continue after oxacillin-mediated acylation of native PBPs.	Oxacillin	152-161	AT695_RS11765	Staphylococcus aureus	58-84
19017494-4	2008	The purified mPGES-1 was used for the screening of a chemical library of bioactive or drug compounds to identify novel inhibitors, and oxacillin and dyphylline were identified as moderately inhibiting mPGES-1 with IC(50) values of 100 and 200 microM, respectively.	Oxacillin	135-144	prostaglandin E synthase	Mus musculus	13-20
19017494-4	2008	The purified mPGES-1 was used for the screening of a chemical library of bioactive or drug compounds to identify novel inhibitors, and oxacillin and dyphylline were identified as moderately inhibiting mPGES-1 with IC(50) values of 100 and 200 microM, respectively.	Oxacillin	135-144	prostaglandin E synthase	Mus musculus	201-208
11023483-5	2000	Stimulation of RAW 264.7 murine macrophages with pneumococci and oxacillin led to significantly higher inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation than did the same concentrations of pneumococci and clindamycin.	Oxacillin	65-74	nitric oxide synthase 2, inducible	Mus musculus	103-134
18503189-4	2008	Deletion of crp significantly increased the resistance of the E. coli strain to oxacillin, azithromycin, erythromycin and crystal violet.	Oxacillin	80-89	catabolite gene activator protein	Escherichia coli	12-15
16400877-9	2005	The 1100 MRSA isolates distributed to four antibiotic resistance patterns on the basis of their resistance to oxacillin, penicillin, amoxicillin+clavulanic acid, azithromycin, clindamycin, amikacin, gentamicin, ciprofloxacin, trimethoprim+sulphamethoxasole, vancomycin and teicoplanin.	Oxacillin	110-119	solute carrier family 9 member A6	Homo sapiens	9-13
11357444-8	2001	The methicillin (oxacillin)-resistant S. aureus (MRSA, ORSA) stems usually present the phenomenon of multiresistance, i.e. the resistance towards substances of several classes of antibiotics, and, therefore, are not only resistant to all beta-lactamantibiotics (penicillins, cephalosporins, carbapenems).	Oxacillin	17-26	solute carrier family 9 member A6	Homo sapiens	49-53
17959028-1	2007	AIM: To investigate the oxacillin susceptibility restoration of methicillin-resistant Staphylococcus aureus (MRSA) by targeting the signaling pathway of blaR1- blaZ with a DNAzyme.	Oxacillin	24-33	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	153-158
17959028-1	2007	AIM: To investigate the oxacillin susceptibility restoration of methicillin-resistant Staphylococcus aureus (MRSA) by targeting the signaling pathway of blaR1- blaZ with a DNAzyme.	Oxacillin	24-33	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	160-164
17108271-0	2006	Identification of different clonal complexes and diverse amino acid substitutions in penicillin-binding protein 2 (PBP2) associated with borderline oxacillin resistance in Canadian Staphylococcus aureus isolates.	Oxacillin	148-157	AT695_RS10295	Staphylococcus aureus	85-113
17108271-0	2006	Identification of different clonal complexes and diverse amino acid substitutions in penicillin-binding protein 2 (PBP2) associated with borderline oxacillin resistance in Canadian Staphylococcus aureus isolates.	Oxacillin	148-157	AT695_RS10295	Staphylococcus aureus	115-119
17108271-10	2006	Plasmid-mediated expression of pbp2 from an ST25 or ST1 isolate in S. aureus RN6390 increased its oxacillin MIC from 0.25 to 4 microg ml(-1), while pbp2 from a susceptible strain, ATCC 25923, had no effect.	Oxacillin	98-107	AT695_RS10295	Staphylococcus aureus	31-35
16207979-4	2005	A novel SCCmec-N1 of approximately 30 kb, associated with a dfrA gene and a ccr 4-related recombinase complex, was identified in a large number of low-level oxacillin-resistant isolates, which descended from the successful clonal complex CC 45 and are spreading among intraveneous drug users.	Oxacillin	157-166	trimethoprim resistant dihydrofolate reductase	Staphylococcus aureus	60-64
14523105-4	2003	A large number of genes, including ones encoding proteins involved in cell-wall metabolism (including pbpB, murZ, fmt and vraS) and stress responses (including msrA, htrA, psrA and hslO), were upregulated by oxacillin, D-cycloserine or bacitracin.	Oxacillin	208-217	ABC transporter permease protein	Staphylococcus aureus	160-164
12604538-0	2003	Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin.	Oxacillin	124-133	AT695_RS10295	Staphylococcus aureus	33-61
11717515-2	2001	A member of the class D family of serine beta-lactamases, OXA-1 is especially active against the penicillins oxacillin and cloxacillin and is now found in 10% of E. coli clinical isolates.	Oxacillin	109-118	beta-lactamase OXA-1 precursor	Escherichia coli	58-63
11023483-5	2000	Stimulation of RAW 264.7 murine macrophages with pneumococci and oxacillin led to significantly higher inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation than did the same concentrations of pneumococci and clindamycin.	Oxacillin	65-74	nitric oxide synthase 2, inducible	Mus musculus	136-140
11023483-5	2000	Stimulation of RAW 264.7 murine macrophages with pneumococci and oxacillin led to significantly higher inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation than did the same concentrations of pneumococci and clindamycin.	Oxacillin	65-74	tumor necrosis factor	Mus musculus	146-167
11023483-5	2000	Stimulation of RAW 264.7 murine macrophages with pneumococci and oxacillin led to significantly higher inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation than did the same concentrations of pneumococci and clindamycin.	Oxacillin	65-74	tumor necrosis factor	Mus musculus	169-172
34618036-5	2021	OBJECTIVES: We aimed: (i) to investigate the combined effects of daptomycin and oxacillin on the lipid composition of the cellular membrane of both daptomycin-resistant and -susceptible MRSA strains; and (ii) to assess the involvement of the post-translocational protein PrsA, which plays an important role in oxacillin resistance in MRSA, in membrane lipid composition and remodelling during daptomycin resistance/beta-lactam sensitization.	Oxacillin	310-319	glutaredoxin 5	Homo sapiens	271-275
10435340-0	1998	Oxacillin residues in milk after drying off with Stapenor Retard TS.	Oxacillin	0-9	Weaning weight-maternal milk	Bos taurus	22-26
9879973-3	1998	Whole bacterial cells and isolated PG from these strains, grown in the presence of oxacillin, showed a significantly reduced stimulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 release by human monocytes in a concentration-dependent fashion.	Oxacillin	83-92	interleukin 1 beta	Homo sapiens	170-192
9879973-3	1998	Whole bacterial cells and isolated PG from these strains, grown in the presence of oxacillin, showed a significantly reduced stimulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 release by human monocytes in a concentration-dependent fashion.	Oxacillin	83-92	interleukin 6	Homo sapiens	197-201
7628197-0	1995	Influence of beta-lactamase inhibitors on the activity of oxacillin against methicillin-resistant Staphylococcus aureus.	Oxacillin	58-67	beta-lactamase	Staphylococcus aureus	13-27
7628197-5	1995	The results suggest that beta-lactamase production probably plays a role in resistance to oxacillin in those MRSA strains of low-level oxacillin resistance.	Oxacillin	90-99	beta-lactamase	Staphylococcus aureus	25-39
7628197-5	1995	The results suggest that beta-lactamase production probably plays a role in resistance to oxacillin in those MRSA strains of low-level oxacillin resistance.	Oxacillin	135-144	beta-lactamase	Staphylococcus aureus	25-39
7730232-5	1994	However, the detergent had no effect on the bacteriolytic enzyme profile or the susceptibility of the bacterial cell wall to bacteriolytic enzymes, nor did it promote the binding of oxacillin to the penicillin-binding protein (PBP) 2A.	Oxacillin	182-191	AT695_RS11765	Staphylococcus aureus	199-225
1810191-0	1991	Comparison of conventional susceptibility tests with direct detection of penicillin-binding protein 2a in borderline oxacillin-resistant strains of Staphylococcus aureus.	Oxacillin	117-126	AT695_RS10295	Staphylococcus aureus	73-101
2404087-9	1990	Thus this trial demonstrates that treatment with prophylactic oxacillin can decrease the incidence of catheter-related sepsis in patients undergoing immunotherapy with interleukin-2 (IL-2).	Oxacillin	62-71	interleukin 2	Homo sapiens	168-181
2404087-9	1990	Thus this trial demonstrates that treatment with prophylactic oxacillin can decrease the incidence of catheter-related sepsis in patients undergoing immunotherapy with interleukin-2 (IL-2).	Oxacillin	62-71	interleukin 2	Homo sapiens	183-187
9789363-10	1998	MRSA-strains were more resistant to imipenem, ofloxacin, gentamicin, trimethoprim-sulfamethoxazole, tetracycline, erythromycin and clindamycin as oxacillin-sensitive Straphylococcus aureus strains.	Oxacillin	146-155	solute carrier family 9 member A6	Homo sapiens	0-4
10681822-1	1998	MRSA and MRSE were identified by detecting oxacillin resistance of 107 strains of staphylococci from clinical sources.	Oxacillin	43-52	solute carrier family 9 member A6	Homo sapiens	0-4
9023664-0	1996	Identification of mec-related oxacillin resistance in staphylococci by the Etest.	Oxacillin	30-39	C-C motif chemokine ligand 28	Homo sapiens	18-21
7493542-1	1995	The effect of liver intoxication by carbon tetrachloride (CCl4) on the hepatic local disposition using oxacillin as a test drug and bovine serum albumin (BSA) as a reference substance was evaluated by single-pass bolus input method in the isolated perfused rat liver.	Oxacillin	103-112	C-C motif chemokine ligand 4	Rattus norvegicus	58-62
7493542-4	1995	Hepatic recovery ratio FH of oxacillin increased from 50% to 80%, with an increase in liver intoxication by CCl4; whereas FH of BSA was naturally 100%.	Oxacillin	29-38	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
7493542-8	1995	The intensive increases in tH and sigma 2/tH2 of oxacillin with the liver intoxication by CCl4 were explained by increases in the extent of distribution and nonequilibrium distribution, respectively.	Oxacillin	49-58	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
7811022-10	1994	AsbB1 was a class D enzyme most closely related to the oxacillin-hydrolyzing enzyme OXA-1, with 34% amino acid sequence identity.	Oxacillin	55-64	beta-lactamase OXA-1 precursor	Escherichia coli	84-89
8320471-0	1993	[MICs of oxacillin for MRSA: a comparative study of strains from staff and patients].	Oxacillin	9-18	solute carrier family 9 member A6	Homo sapiens	23-27
34618036-6	2021	RESULTS: The combination of microbiological and biochemical studies, with fluorescence microscopy using lipid probes, showed that the lipid composition and surface charge of the daptomycin-resistant cells exposed to daptomycin/oxacillin were dependent on antibiotic concentration and directly associated with PrsA, which influenced cardiolipin remodelling/relocation.	Oxacillin	227-236	glutaredoxin 5	Homo sapiens	309-313
34618036-7	2021	CONCLUSIONS: Our findings show that PrsA, in addition to its post-transcriptional role in the maturation of PBP 2a, is a key mediator of cell membrane remodelling connected to the see-saw effect and may have a key role in the resensitization of daptomycin-resistant strains to beta-lactams, such as oxacillin.	Oxacillin	299-308	glutaredoxin 5	Homo sapiens	36-40
6124421-6	1982	Human alanine aminopeptidase activity is reduced by several beta-lactam antibiotics, with the cloxacillin, oxacillin, and methicillin Ki values being 0.51 mM, 1.6 mM, and 2.4 mM respectively.	Oxacillin	96-105	carboxypeptidase Q	Homo sapiens	14-28
35501756-8	2022	After ASP implementation, the trend toward an increase of oxacillin-resistant Staphylococcus aureus, ceftriaxone-resistant Escherichia coli, and meropenem-resistant Pseudomonas aeruginosa was reversed.	Oxacillin	58-67	assembly factor for spindle microtubules	Homo sapiens	6-9
3266728-0	1988	Role of beta-lactamase and different testing conditions in oxacillin-borderline-susceptible staphylococci.	Oxacillin	59-68	beta-lactamase	Staphylococcus aureus	8-22
3266728-5	1988	For 6 of 10 beta-lactamase-positive strains, there was a greater-than-twofold-dilution reduction in oxacillin MICs with the addition of clavulanic acid or sulbactam.	Oxacillin	100-109	beta-lactamase	Staphylococcus aureus	12-26
3266728-6	1988	Of the four strains that became resistant with incubation at the lower temperature, a clavulanic acid effect was observed in three but only at 35 degrees C. The oxacillin MIC for one of the beta-lactamase-negative strains was also reduced with clavulanic acid; however, this strain was inhibited by 1 microgram of clavulanic acid per ml alone.	Oxacillin	161-170	beta-lactamase	Staphylococcus aureus	190-204
6819796-7	1982	This effect appeared to be variable for strains producing the oxacillin-hydrolysing enzyme (OXA-1), such as E. coli and P. aeruginosa.	Oxacillin	62-71	beta-lactamase OXA-1 precursor	Escherichia coli	92-97
34918102-8	2022	RESULTS: A deletion in blaR1 in most OS-MRSA isolates (7/9; 77.78%) was found using NGS data, and overexpression of OR-blaR1 in OS-MRSA isolate ET-16 restored its oxacillin resistance.	Oxacillin	163-172	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	23-28
34918102-8	2022	RESULTS: A deletion in blaR1 in most OS-MRSA isolates (7/9; 77.78%) was found using NGS data, and overexpression of OR-blaR1 in OS-MRSA isolate ET-16 restored its oxacillin resistance.	Oxacillin	163-172	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	119-124
34918102-10	2022	Plasmid containing the bla locus was lost in most induced isolates during the induction process and complementation of blaR1-blaI from OS-MRSA ET-16 to the induced isolate ET-16I converted its oxacillin susceptibility.	Oxacillin	193-202	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	119-124
34918102-11	2022	CONCLUSIONS: Deletion in blaR1 resulted in oxacillin susceptibility in OS-MRSA, and loss of the bla regulator in OS-MRSA restored oxacillin resistance.	Oxacillin	43-52	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	25-30
35052944-6	2022	Results show that cefotaxime is the preferred inducer for CTX-M-15 and amoxicillin for TEM-1, whereas oxacillin for OXA-2.	Oxacillin	102-111	OXA-2	Escherichia coli	116-121
3389954-1	1988	Interaction of oxacillin, cloxacillin, dicloxacillin, phenoxymethylpenicillin, methicillin, nafcillin and benzylpenicillin with human serum albumin (HSA) was studied with flow microcalorimetry and differential scanning calorimetry.	Oxacillin	15-24	albumin	Homo sapiens	134-147
32004624-6	2020	The time-kill curve assays of apitoxin or melittin with oxacillin exhibited bactericidal synergism against MRSA isolates.	Oxacillin	56-65	melittin	Apis mellifera	42-50
318118-2	1977	NTP1 plasmid-coded beta-lactamase was found to be periplasmically located in the host Escherichia coli cell, to have a molecular weight of about 25,000, and to show a relatively low activity against oxacillin and methicillin compared with benzylpenicillin.	Oxacillin	199-208	beta-lactamase	Escherichia coli	19-33
31523763-1	2020	Traditional antimicrobial susceptibility test methods for detection of S. aureus resistant to oxacillin (MRSA) such as disk diffusion, broth microdilution, and oxacillin screen plate require 18-24 h of incubation after having the organism growing in pure culture.	Oxacillin	94-103	solute carrier family 9 member A6	Homo sapiens	105-109
31844017-2	2020	Using the Food and Drug Administration Adverse Event Reports System (FAERS), oxacillin was observed to have a lower proportion of reports of acute renal failure (ROR 5.3 95% CI 3.1-9.3 vs. 21.3 95% CI 15.8-28.6) and hypokalemia (ROR 0.7 95% CI 0.1-4.8 vs 11.4 95% CI 7.1-18.3) compared to nafcillin.	Oxacillin	77-86	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	162-165
31844017-2	2020	Using the Food and Drug Administration Adverse Event Reports System (FAERS), oxacillin was observed to have a lower proportion of reports of acute renal failure (ROR 5.3 95% CI 3.1-9.3 vs. 21.3 95% CI 15.8-28.6) and hypokalemia (ROR 0.7 95% CI 0.1-4.8 vs 11.4 95% CI 7.1-18.3) compared to nafcillin.	Oxacillin	77-86	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	229-232
31523763-1	2020	Traditional antimicrobial susceptibility test methods for detection of S. aureus resistant to oxacillin (MRSA) such as disk diffusion, broth microdilution, and oxacillin screen plate require 18-24 h of incubation after having the organism growing in pure culture.	Oxacillin	160-169	solute carrier family 9 member A6	Homo sapiens	105-109
30074012-6	2018	The polymerase chain reaction amplification of the coa, mecA, and spa gene was carried out in the clinical isolates showed resistant to oxacillin.	Oxacillin	136-145	surfactant protein A2	Homo sapiens	66-69
30460607-5	2019	RESULTS: Twenty-one isolates, 15 hVISA and 6 MRSA, showed synergy between oxacillin and vancomycin by checkerboard assay with fractional inhibitory concentration indices of <= 0.5.	Oxacillin	74-83	mitochondrial antiviral signaling protein	Homo sapiens	33-38
30460607-6	2019	The addition of oxacillin to vancomycin resulted in a reduction in baseline vancomycin MIC from 1-2 to 0.06-0.5 microg/ml against MRSA and hVISA isolates.	Oxacillin	16-25	mitochondrial antiviral signaling protein	Homo sapiens	139-144
30460607-7	2019	In the time-kill assay, the combination of oxacillin and vancomycin resulted in synergistic activity against hVISA (n = 23) and MRSA (n = 7) isolates.	Oxacillin	43-52	mitochondrial antiviral signaling protein	Homo sapiens	109-114
30460607-9	2019	Overall, for hVISA and MRSA, the combination of oxacillin plus vancomycin had greater antibacterial effect than each individual drug alone.	Oxacillin	48-57	mitochondrial antiviral signaling protein	Homo sapiens	13-18
30460607-10	2019	CONCLUSION: The present study showed the potential activity of vancomycin plus oxacillin combination against hVISA and MRSA isolates.	Oxacillin	79-88	mitochondrial antiviral signaling protein	Homo sapiens	109-114
30150231-6	2018	Here, we show that SSR42 is the effector of Rsp in transcription regulation of the alpha-toxin gene, hla SSR42 transcription is enhanced after exposure of S. aureus to subinhibitory concentrations of oxacillin which thus leads to an SSR42-dependent increase in hemolysis.	Oxacillin	200-209	AT695_RS01930	Staphylococcus aureus	89-94
25672426-1	2015	OBJECTIVE: To establish the risk factors for joint infection by oxacillin-resistant Staphylococcus aureus (MRSA) using clinical and epidemiological data.	Oxacillin	64-73	solute carrier family 9 member A6	Homo sapiens	107-111
28412568-8	2017	One MRSA CC398 (spa-type t899) isolate was detected (oxacillin MIC=32mg/L and mecA-positive), which presented resistance to penicillin, tetracycline, and ciprofloxacin and contained the genes of immune evasion cluster (IEC) system (type B).	Oxacillin	53-62	pulmonary surfactant-associated protein A	Sus scrofa	16-19
26709182-15	2016	Among the isolates with an oxacillin resistance phenotype, 12 were positive for the blaZ gene, and 9 of them were mecA-positive.	Oxacillin	27-36	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	84-88
29755606-7	2018	We detected a high resistance rate to common antibiotics, e.g. 83% of S. aureus isolates were resistant to oxacillin (MRSA).	Oxacillin	107-116	solute carrier family 9 member A6	Homo sapiens	118-122
29258622-6	2017	MRSA was detected using both Cefoxitin (30 mug) and Oxacillin (6 mug) (Oxoid Ltd. England) discs in combination and associated factors were assessed using self-administered pretested questionnaires, which were delivered to the children"s parents/guardians.	Oxacillin	52-61	solute carrier family 9 member A6	Homo sapiens	0-4
28378583-6	2017	It also potentiated the anti-MRSA activity of oxacillin in a synergistic fashion, resulting in an 8-fold increase in oxacillin potency, for a MIC of 16 mug mL-1.	Oxacillin	46-55	L1 cell adhesion molecule	Mus musculus	156-160
28378583-6	2017	It also potentiated the anti-MRSA activity of oxacillin in a synergistic fashion, resulting in an 8-fold increase in oxacillin potency, for a MIC of 16 mug mL-1.	Oxacillin	117-126	L1 cell adhesion molecule	Mus musculus	156-160
27473500-4	2016	The considerable increase in extracellular and membrane-bound beta-lactamase activities was observed in S. aureus ATCC exposed to oxacillin (>26 mumol/min/mL).	Oxacillin	130-139	beta-lactamase	Staphylococcus aureus	62-76
24574803-5	2014	RESULTS: Orally and ip administered melatonin, Neu-P11, and Neu-P12 reduced pain responses in a dose-dependent manner.	Oxacillin	64-67	erb-b2 receptor tyrosine kinase 2	Mus musculus	60-63
24738238-0	2013	[Estimation of MRSA susceptibility to oxacillin, cefoxitine, vancomycin and daptomycin].	Oxacillin	38-47	solute carrier family 9 member A6	Homo sapiens	15-19
23422917-0	2013	Novel combinations of vancomycin plus ceftaroline or oxacillin against methicillin-resistant vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA.	Oxacillin	53-62	mitochondrial antiviral signaling protein	Homo sapiens	140-144
23422917-2	2013	Using time-kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3 of 5 VISA and 1 of 5 hVISA isolates or 5 of 5 VISA and 4 of 5 hVISA isolates, respectively.	Oxacillin	40-49	mitochondrial antiviral signaling protein	Homo sapiens	96-100
23422917-2	2013	Using time-kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3 of 5 VISA and 1 of 5 hVISA isolates or 5 of 5 VISA and 4 of 5 hVISA isolates, respectively.	Oxacillin	40-49	mitochondrial antiviral signaling protein	Homo sapiens	112-117
23422917-2	2013	Using time-kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3 of 5 VISA and 1 of 5 hVISA isolates or 5 of 5 VISA and 4 of 5 hVISA isolates, respectively.	Oxacillin	40-49	mitochondrial antiviral signaling protein	Homo sapiens	113-117
23422917-2	2013	Using time-kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3 of 5 VISA and 1 of 5 hVISA isolates or 5 of 5 VISA and 4 of 5 hVISA isolates, respectively.	Oxacillin	40-49	mitochondrial antiviral signaling protein	Homo sapiens	153-158
23637786-3	2013	Moreover, we showed that oxacillin appeared to be the triggering factor of a beta-lactam-mediated SOS response through lexA/recA regulators, responsible for an increased mutation rate and selection of a HoR derivative.	Oxacillin	25-34	xylosyltransferase 2	Homo sapiens	98-101
23637786-3	2013	Moreover, we showed that oxacillin appeared to be the triggering factor of a beta-lactam-mediated SOS response through lexA/recA regulators, responsible for an increased mutation rate and selection of a HoR derivative.	Oxacillin	25-34	RAD51 recombinase	Homo sapiens	124-128
23374512-10	2013	RESULTS: The vancomycin-resistant isolate CP2 was found to be resistant to oxacillin, chloramphenicol, erythromycin, rifampicin, gentamicin, tetracycline and ciprofloxacin, as well.	Oxacillin	75-84	ceruloplasmin	Homo sapiens	42-45
24738238-2	2013	Therefore, correct laboratory identification of the MRSA phenotype based on the use of the marker antibiotic cefoxitine, as a more susceptibile one vs. oxacillin, is of great importance.	Oxacillin	152-161	solute carrier family 9 member A6	Homo sapiens	52-56
24738238-5	2013	The results of our study on estimation of susceptibility of 316 MRSA isolates from several regions of Russia to oxacillin, cefoxitine, vancomycin and daptomycin are presented herein.	Oxacillin	112-121	solute carrier family 9 member A6	Homo sapiens	64-68
21396483-2	2011	In the present study, we firstly found that artesunate in combination with oxacillin was capable of protecting mice challenged with live MRSA WHO-2 (WHO-2) and the protection was related to the reduced TNF-alpha and IL-6 levels and decreased bacterial load.	Oxacillin	75-84	tumor necrosis factor	Mus musculus	202-211
22985884-3	2012	Resistance to DAP (DAP(r)) has been reported in MRSA and is mostly accompanied by a parallel decrease in oxacillin resistance, a process known as the "seesaw effect."	Oxacillin	105-114	death associated protein	Homo sapiens	14-17
22985884-3	2012	Resistance to DAP (DAP(r)) has been reported in MRSA and is mostly accompanied by a parallel decrease in oxacillin resistance, a process known as the "seesaw effect."	Oxacillin	105-114	death associated protein	Homo sapiens	19-22
22438436-2	2012	The relationship between mecA gene carriage, phenotypic expression of the gene by PBP-2a production and in vitro resistance to the beta-lactam antibiotics oxacillin, cefazolin and amoxicillin/clavulanate was determined for 85 CoNS blood isolates randomly obtained from our collection of isolates from neonates with CoNS sepsis.	Oxacillin	155-164	phosphatidylethanolamine binding protein 1	Homo sapiens	82-85
22438436-3	2012	METHODS: The relationship between mecA gene carriage, phenotypic expression of the gene by PBP-2a production and in vitro resistance to the beta-lactam antibiotics oxacillin, cefazolin and amoxicillin/clavulanate was determined for randomly obtained CoNS blood isolates from our collection of isolates from neonates with CoNS sepsis.	Oxacillin	164-173	phosphatidylethanolamine binding protein 1	Homo sapiens	91-94
22261238-7	2012	The association between the presence of IS256 and the resistance was particularly significant for certain antibiotics: cefovecin, amikacin, gentamicin and oxacillin (chi(2)p-value<0.05).	Oxacillin	155-164	IS256, transposase	Staphylococcus aureus	40-45
22261238-8	2012	However, there was a striking result in frequency of strains resistant to gentamicin and oxacillin, suggesting a specific association between the presence of the IS256 element and the determinants for the resistance to these antibiotics.	Oxacillin	89-98	IS256, transposase	Staphylococcus aureus	162-167
22168812-6	2011	RESULTS: Oxacillin, moxifloxacin and linezolid led to the development of a hyper-adhesive phenotype in the fibronectin adhesion assay that was consistent with an increase in fnbA/B transcription.	Oxacillin	9-18	fibronectin 1	Homo sapiens	107-118
21976769-9	2011	The rates of resistance (including intermediate) for hVISA were as follows: oxacillin, 82%; erythromycin, 82%; clindamycin, 73%; levofloxacin, 73%; trimethoprim-sulfamethoxazole, 9%; and daptomycin, 9%.	Oxacillin	76-85	mitochondrial antiviral signaling protein	Homo sapiens	53-58
21396483-2	2011	In the present study, we firstly found that artesunate in combination with oxacillin was capable of protecting mice challenged with live MRSA WHO-2 (WHO-2) and the protection was related to the reduced TNF-alpha and IL-6 levels and decreased bacterial load.	Oxacillin	75-84	interleukin 6	Mus musculus	216-220