PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	trimethylated histone	175-196	lysine demethylase 6B	Homo sapiens	40-45
31350176-4	2019	Mechanistically, Setdb2 trimethylated histone 3 at NF-kappaB binding sites on inflammatory cytokine gene promoters to suppress transcription.	trimethylated histone	24-45	SET domain bifurcated histone lysine methyltransferase 2	Homo sapiens	17-23
31350176-4	2019	Mechanistically, Setdb2 trimethylated histone 3 at NF-kappaB binding sites on inflammatory cytokine gene promoters to suppress transcription.	trimethylated histone	24-45	nuclear factor kappa B subunit 1	Homo sapiens	51-60
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	trimethylated histone	175-196	interleukin 6	Homo sapiens	80-93
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	trimethylated histone	175-196	interleukin 12B	Homo sapiens	98-113
28734980-7	2017	Mechanistically, PHF8 regulates hypoxia inducible genes mainly through sustaining the level of trimethylated histone 3 lysine 4 (H3K4me3), an active mark in transcriptional regulation.	trimethylated histone	95-116	PHD finger protein 8	Homo sapiens	17-21
26564862-4	2015	This reprogramming process enriched trimethylated histone H3 lysine 4, monoacetylated histone H3 lysine 9, and Baf60c at the Nkx2.5 cardiac enhancer region by the chromatin immunoprecipitation quantitative polymerase chain reaction assay.	trimethylated histone	36-57	NK2 homeobox 5	Homo sapiens	125-131
25820690-4	2015	We aimed to determine the levels of trimethylated histone 3 at lysine residue 27 (H3K27me3), a well-known repressive mark, by immunoassay of fresh tissues and immunohistochemistry (IHC) of an endometriosis-focused tissue microarray.	trimethylated histone	36-57	microtubule affinity regulating kinase 1	Homo sapiens	117-121
26241940-8	2015	TGF-beta treatment induced the accumulation of trimethylated histone H3K4 on the gene promoters by recruiting a methyltransferase complex.	trimethylated histone	47-68	transforming growth factor, beta 1	Mus musculus	0-8
18845545-4	2008	Furthermore, we find that Orc2p physically interacts with trimethylated histone 3 lysine 4 (H3K4) on chromatin by co-immunoprecipitation.	trimethylated histone	58-79	origin recognition complex subunit 2	Saccharomyces cerevisiae S288C	26-31
24574043-7	2014	Trimethylated histone H3-Lys27 occupancy was significantly increased on Cebpalpha and Rxralpha promoters in SAH-treated adipocytes, consistent with the reduction in gene expression.	trimethylated histone	0-21	retinoid X receptor alpha	Mus musculus	86-94
23077255-3	2012	In the crystal structure of a trimethylated histone H3 lysine 4 (H3K4) peptide bound to the tudor-like domains of Spindlin1 presented here, an atypical mode of methyllysine recognition by an aromatic pocket of Spindlin1 is observed.	trimethylated histone	30-51	spindlin 1	Homo sapiens	114-123
23077255-3	2012	In the crystal structure of a trimethylated histone H3 lysine 4 (H3K4) peptide bound to the tudor-like domains of Spindlin1 presented here, an atypical mode of methyllysine recognition by an aromatic pocket of Spindlin1 is observed.	trimethylated histone	30-51	spindlin 1	Homo sapiens	210-219
21167174-3	2011	PHF2, via its PHD, binds Lys4-trimethylated histone 3 in submicromolar affinity and has been reported to have the demethylase activity of monomethylated lysine 9 of histone 3 in vivo.	trimethylated histone	30-51	PHD finger protein 2	Homo sapiens	0-4
20798045-4	2010	Loss of function of Ezh2 removes the repressive mark of trimethylated histone H3 at lysine 27 (H3K27me3) in cortical progenitor cells and also prevents its establishment in postmitotic neurons.	trimethylated histone	56-77	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	20-24
20075941-5	2010	NO-induced repression of Nanog is also associated with binding of trimethylated histone H3 and pSer315 p53 to its promoter region.	trimethylated histone	66-87	Nanog homeobox	Mus musculus	25-30
20648246-6	2010	In addition, a relative increase in trimethylated histone H3 lysine 9 (H3K9M3)-associated DNA starting exactly at the translocation breakpoint and going 2.5 Mb beyond the LRFN5 gene was found.	trimethylated histone	36-57	leucine rich repeat and fibronectin type III domain containing 5	Homo sapiens	171-176
26092847-2	2015	CHD1, which recognizes trimethylated histone H3 lysine 4, has been implicated in transcriptional activation in organisms ranging from yeast to humans.	trimethylated histone	23-44	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	0-4
25631790-4	2015	ROW1 specifically binds trimethylated histone H3 lysine 4 (H3K4me3) in the WOX5 promoter region to repress its transcription.	trimethylated histone	24-45	WUSCHEL related homeobox 5	Arabidopsis thaliana	75-79
23110793-5	2012	Also, literature data are equivocal on the correlation between EZH2 expression and the abundance of trimethylated histone 3 lysine 27 (H3K27me3) motifs in tumors.	trimethylated histone	100-121	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	63-67
22009739-0	2011	Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.	trimethylated histone	124-145	chromodomain Y like	Homo sapiens	20-24
18234970-6	2008	A repressive histone mark, trimethylated histone H3 lysine 9 (Me(3)-K9 H3), was found in untreated parental cells and cells that did not respond to HDAC inhibition with ABCG2 up-regulation.	trimethylated histone	27-48	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	169-174