PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32819975-11	2020	The ability of FUS+GEM to control primary tumor outgrowth was moderately enhanced by either neoadjuvant or adjuvant treatment with anti-PD-1.	fusarubin	15-18	programmed cell death 1	Mus musculus	136-140
32662325-3	2021	Upon the sulfamide drug adsorption onto the stated nanocages, the energy levels of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) were significantly changed, resulting in a decrease in the values of bandgap (E g) that caused enhance in their electrical conductivity.	fusarubin	9-18	ras homolog family member G	Homo sapiens	22-23
32662325-5	2021	Finally, The QTAIM analysis was investigated for both types of structural aspects and electronic properties (such as rho, " " ^"2" rho, G(r), V (r) and H(r)) associated with adsorption of sulfamide molecule on the stated nanocages.	fusarubin	188-197	ras homolog family member G	Homo sapiens	131-137
32656213-6	2020	We demonstrate that FUS may directly stimulate mechanosensory PANX1 localized in endoplasmic reticulum to evoke calcium release from internal stores.	fusarubin	20-23	pannexin 1	Homo sapiens	62-67
32028085-4	2020	In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.	fusarubin	36-39	intercellular adhesion molecule 1	Homo sapiens	160-193
32492056-4	2020	Building on this established technique, we propose to develop FUS-enabled liquid biopsy technique (FUS-LBx) to enhance the release of brain tumor biomarkers (e.g., DNA, RNA, and proteins) into the circulation.	fusarubin	62-65	labial homeobox homolog	Mus musculus	103-106
32492056-12	2020	This study suggests that FUS-LBx could be a safe and effective brain-tumor biomarker release technique, and MRI could be used to develop image-guided FUS-LBx.	fusarubin	25-28	labial homeobox homolog	Mus musculus	29-32
32492056-12	2020	This study suggests that FUS-LBx could be a safe and effective brain-tumor biomarker release technique, and MRI could be used to develop image-guided FUS-LBx.	fusarubin	150-153	labial homeobox homolog	Mus musculus	154-157
32361864-7	2020	Caspase 3 induction in C6 cells relative to control showed increases of 109%, 110%, and 278% for 5-ALA, FUS, and SDT groups, respectively (p < 0.05).	fusarubin	104-107	caspase 3	Homo sapiens	0-9
32361864-8	2020	For the C6 cells, caspase 3 staining positivity was 2.1%, 6.7%, 11.2%, and 39.8% for control, 5-ALA, FUS, and SDT groups, respectively.	fusarubin	101-104	caspase 3	Homo sapiens	18-27
32270718-7	2020	The expression of P16 and Ki-67 in the treated cervical tissues was significantly lower than that before treatment, and the expression of Fas was found up-regulated (all p < .05).Conclusion: FUS therapy appears to be a feasible and effective treatment for patients with HPV positive CIN1.	fusarubin	191-194	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
32206098-8	2020	Results: CRT-NP plus FUS (CFUS) upregulated CRT expression, expanded the population of melanoma TRP-2 specific functional CD4+ and CD8+ T cells and tumor-suppressing M1 phenotype, and increased PD-1 and PD-L1 marker expression in the T cells.	fusarubin	21-24	tRNA proline 2	Mus musculus	96-101
32206098-8	2020	Results: CRT-NP plus FUS (CFUS) upregulated CRT expression, expanded the population of melanoma TRP-2 specific functional CD4+ and CD8+ T cells and tumor-suppressing M1 phenotype, and increased PD-1 and PD-L1 marker expression in the T cells.	fusarubin	21-24	CD274 antigen	Mus musculus	203-208
31575487-10	2020	Western blotting was used to evaluate the correlation between FUS-induced epileptic suppression and the PI3K-mTOR signaling pathway.	fusarubin	62-65	mechanistic target of rapamycin kinase	Rattus norvegicus	109-113
32270718-8	2020	FUS therapy may help to reduce the expression of p16 and Ki-67 and enhance the expression of Fas in the treated cervical tissues to regulate cell proliferation and increase apoptosis, and thus prevent the disease from evolving into high grade lesions.	fusarubin	0-3	cyclin dependent kinase inhibitor 2A	Homo sapiens	49-52
31065903-5	2019	RESULTS: IL-8 levels were significantly higher in the AqH of patients with BU and FUS than in the AqH of control subjects (p < 0.001 and p < 0.001, respectively).	fusarubin	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31508507-6	2019	Several compounds (phenylarsonic acid, phenylbaronic acid, sulfamide) exhibited favorable Kis for SmCA versus two human isoforms.	fusarubin	59-68	U2AF homology motif kinase 1	Homo sapiens	90-93
29339208-5	2018	Next, we demonstrated that FUS-aided MB-shBirc5-lipo-NGR exhibited a higher transfection efficiency compared with the control group.	fusarubin	27-30	reticulon 4 receptor	Homo sapiens	53-56
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	15-18	H3 histone pseudogene 16	Homo sapiens	78-81
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	15-18	tumor protein p53	Homo sapiens	98-101
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	15-18	mitogen-activated protein kinase 1	Homo sapiens	194-197
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	15-18	mitogen-activated protein kinase 14	Homo sapiens	228-231
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	15-18	H3 histone pseudogene 16	Homo sapiens	267-270
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	60-63	H3 histone pseudogene 16	Homo sapiens	78-81
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	60-63	tumor protein p53	Homo sapiens	98-101
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	60-63	mitogen-activated protein kinase 14	Homo sapiens	228-231
31470629-8	2019	The effects of FUS were more potent than those of AFU, with FUS up-regulating p21 expression in a p53-dependent manner, as detected by Western blot analyses, likely the consequence of decreased ERK phosphorylation and increased p38 expression (both of which increase p21 stability).	fusarubin	60-63	H3 histone pseudogene 16	Homo sapiens	267-270
31470629-9	2019	FUS also decreased Akt phosphorylation and resulted in increased Fas ligand production and caspase-8/3-dependent apoptosis.	fusarubin	0-3	AKT serine/threonine kinase 1	Homo sapiens	19-22
31470629-9	2019	FUS also decreased Akt phosphorylation and resulted in increased Fas ligand production and caspase-8/3-dependent apoptosis.	fusarubin	0-3	Fas ligand	Homo sapiens	65-75
31470629-9	2019	FUS also decreased Akt phosphorylation and resulted in increased Fas ligand production and caspase-8/3-dependent apoptosis.	fusarubin	0-3	caspase 8	Homo sapiens	91-102
30981691-4	2019	Taking our previously discovered CXCR4 modulator RB-108 as the lead compound, a series of derivatives were synthesized structurally modifying and optimizing the amide and sulfamide side chains.	fusarubin	171-180	C-X-C motif chemokine receptor 4	Rattus norvegicus	33-38
31057396-5	2019	The potential molecular mechanism of FUS assisting NK cell therapy was also initially explored through evaluating the expression of ICAM1 and CX3CL1 by qRT-PCR.	fusarubin	37-40	intercellular adhesion molecule 1	Homo sapiens	132-137
31057396-5	2019	The potential molecular mechanism of FUS assisting NK cell therapy was also initially explored through evaluating the expression of ICAM1 and CX3CL1 by qRT-PCR.	fusarubin	37-40	C-X3-C motif chemokine ligand 1	Homo sapiens	142-148
31057396-7	2019	The qRT-PCR results also showed that CX3CL1 may be involved in the process of FUS-assisted NK cell infiltration.	fusarubin	78-81	C-X3-C motif chemokine ligand 1	Homo sapiens	37-43
30074266-4	2018	The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined.	fusarubin	16-25	butyrylcholinesterase	Homo sapiens	78-92
30074266-4	2018	The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined.	fusarubin	16-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
30074266-4	2018	The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined.	fusarubin	16-25	butyrylcholinesterase	Homo sapiens	143-147
30150769-6	2018	In this study, we aimed to evaluate whether the use of FUS-induced BBB opening to enhance GSK-3 inhibitor delivery, which would bring additive effect of Abeta plaque clearance by FUS with the reduction of Abeta plaque synthesis by GSK-3 inhibitor in an AD mice model.	fusarubin	55-58	glycogen synthase kinase 3 beta	Mus musculus	90-95
30150769-6	2018	In this study, we aimed to evaluate whether the use of FUS-induced BBB opening to enhance GSK-3 inhibitor delivery, which would bring additive effect of Abeta plaque clearance by FUS with the reduction of Abeta plaque synthesis by GSK-3 inhibitor in an AD mice model.	fusarubin	55-58	glycogen synthase kinase 3 beta	Mus musculus	231-236
30150769-6	2018	In this study, we aimed to evaluate whether the use of FUS-induced BBB opening to enhance GSK-3 inhibitor delivery, which would bring additive effect of Abeta plaque clearance by FUS with the reduction of Abeta plaque synthesis by GSK-3 inhibitor in an AD mice model.	fusarubin	179-182	glycogen synthase kinase 3 beta	Mus musculus	90-95
30150769-7	2018	FUS-induced BBB opening on APPswe/PSEN1-dE9 transgenic mice was performed unilaterally, with the contralateral hemisphere serving as a reference.	fusarubin	0-3	presenilin 1	Mus musculus	34-39
29109793-4	2017	Methods: Differential expression of NFkappaB signaling pathway genes was assessed in rats at 6 h and 4 days following a FUS-mediated increase in BBB permeability.	fusarubin	120-123	nuclear factor kappa B subunit 1	Homo sapiens	36-44
28738704-4	2017	The comparison with the structure of hCA II in complex with its sulphamide analogue revealed that the two inhibitors adopt a completely different binding mode within the hCA II active site.	fusarubin	64-74	carbonic anhydrase 2	Homo sapiens	37-43
28738704-4	2017	The comparison with the structure of hCA II in complex with its sulphamide analogue revealed that the two inhibitors adopt a completely different binding mode within the hCA II active site.	fusarubin	64-74	carbonic anhydrase 2	Homo sapiens	170-176
27749053-0	2016	Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).	fusarubin	0-9	carboxypeptidase B2	Homo sapiens	74-117
28511006-7	2017	After only a single treatment, our strategy led to therapeutically relevant levels of GDNF protein content in the FUS-targeted regions in the striatum of the 6-OHDA-induced rat model of PD, which lasted at least up to 10 weeks.	fusarubin	114-117	glial cell derived neurotrophic factor	Rattus norvegicus	86-90
27345430-5	2016	Immunohistochemistry staining of BDNF revealed that FUS-enhanced IN delivery achieved similar locally enhanced delivery as the established FUS technique.	fusarubin	52-55	brain derived neurotrophic factor	Mus musculus	33-37
27235980-2	2016	We have previously demonstrated that a separated gene-carrying liposome and MBs administration plus FUS exposure can deliver genes into the brain, with the successful expression of the reporter gene and glial cell line-derived neurotrophic factor (GDNF) gene.	fusarubin	100-103	glial cell line derived neurotrophic factor	Mus musculus	203-246
27068142-0	2016	Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.	fusarubin	84-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
27563403-0	2016	Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.	fusarubin	43-52	histidine triad nucleotide binding protein 1	Homo sapiens	99-105
27068142-3	2016	The novel urea and sulfamide derivatives were tested for inhibition of hCA I, II and AChE enzymes.	fusarubin	19-28	carbonic anhydrase 1	Homo sapiens	71-76
27068142-3	2016	The novel urea and sulfamide derivatives were tested for inhibition of hCA I, II and AChE enzymes.	fusarubin	19-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
26611920-4	2016	Since this sulfamide MEK inhibitor displayed an exceptionally favorable PK profile with low brain penetration potential despite being highly oral bioavailable, we elected to keep the sulfamide capping group intact while taming its unwanted off-target activity by optimizing the structural surroundings.	fusarubin	11-20	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24
26795114-0	2016	Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.	fusarubin	0-9	carbonic anhydrase 7	Homo sapiens	37-59
26611920-4	2016	Since this sulfamide MEK inhibitor displayed an exceptionally favorable PK profile with low brain penetration potential despite being highly oral bioavailable, we elected to keep the sulfamide capping group intact while taming its unwanted off-target activity by optimizing the structural surroundings.	fusarubin	183-192	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24
26985287-3	2016	Potency optimization afforded two tool compounds, sulfonamide EPZ031686 and sulfamide EPZ030456, with cellular potency at a level sufficient to probe the in vitro biology of SMYD3 inhibition.	fusarubin	76-85	SET and MYND domain containing 3	Mus musculus	174-179
26071631-8	2015	With longitudinal observation of IVIS monitoring, animals with FUS treatment showed significant promotion of LpDNA release into the CNS and demonstrated enhanced expression of genes upon sonication with FUS-BBB opening, while both the luciferase and GDNF protein expression were successfully measured via Western blotting.	fusarubin	63-66	glial cell derived neurotrophic factor	Homo sapiens	250-254
25071945-4	2014	With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied.	fusarubin	56-59	plexin A2	Homo sapiens	5-8
25586140-5	2015	The objective of the study was to investigate whether safe and efficient NTN delivery can be achieved through FUS-induced BBB opening via intravenous administration, and thus trigger the neuroregeneration cascade in the nigrostriatal pathway.	fusarubin	110-113	neurturin	Mus musculus	73-76
25586140-7	2015	FUS significantly enhanced the delivery of NTN compared with the direct injection technique, whereas triggering of the signaling cascade was detected downstream to the neuronal nuclei.	fusarubin	0-3	neurturin	Mus musculus	43-46
25921269-8	2015	These results show that hCA I, II, and AChE were effectively inhibited by the novel sulfamoylcarbamates 17-21 and sulfamide derivatives 22-26.	fusarubin	114-123	carbonic anhydrase 1	Homo sapiens	24-29
25223956-6	2014	Among these compounds, the novel sulfamide derivative 17 showed the most potent inhibitory effect against hCA I (Ki : 153.88 nM), while sulfamide derivative 26 showed the highest inhibitory potential against hCA II (Ki : 117.80 nM).	fusarubin	33-42	carbonic anhydrase 1	Homo sapiens	106-111
25223956-6	2014	Among these compounds, the novel sulfamide derivative 17 showed the most potent inhibitory effect against hCA I (Ki : 153.88 nM), while sulfamide derivative 26 showed the highest inhibitory potential against hCA II (Ki : 117.80 nM).	fusarubin	136-145	carbonic anhydrase 2	Homo sapiens	208-214
25198897-0	2014	Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors.	fusarubin	47-56	tumor protein p53	Homo sapiens	95-98
25198897-0	2014	Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors.	fusarubin	47-56	MDM2 proto-oncogene	Homo sapiens	99-103
24587228-7	2014	The experimental results showed that MBs/FUS significantly increased the cerebral content of EPO by bettering vascular permeability.	fusarubin	41-44	erythropoietin	Rattus norvegicus	93-96
24651609-11	2014	These results provide new opportunities for the development of specific PPARalpha-activating drugs focused on sulfamide derivatives with a long alkyl chain for the treatment of metabolic dysfunction.	fusarubin	110-119	peroxisome proliferator activated receptor alpha	Rattus norvegicus	72-81
24157370-1	2013	Introducing a sulfamide moiety to our coumarin derivatives afforded enhanced Raf/MEK inhibitory activity concomitantly with an acceptable PK profile.	fusarubin	14-23	mitogen-activated protein kinase kinase 7	Homo sapiens	81-84
24224693-2	2013	Especially when a sulfonamide or sulfamide moiety was added, resulting compounds exhibited not only potent CB1R activity but also a desired tPSA value over 90 A(2), a threshold considered to possess a low probability to cross BBB, leading to the identification of compound 4 (B/P = 1/64) as a peripherally restricted CB1R antagonist.	fusarubin	33-42	cannabinoid receptor 1 (brain)	Mus musculus	107-111
24224693-2	2013	Especially when a sulfonamide or sulfamide moiety was added, resulting compounds exhibited not only potent CB1R activity but also a desired tPSA value over 90 A(2), a threshold considered to possess a low probability to cross BBB, leading to the identification of compound 4 (B/P = 1/64) as a peripherally restricted CB1R antagonist.	fusarubin	33-42	zinc finger protein 185	Mus musculus	278-286
24224693-2	2013	Especially when a sulfonamide or sulfamide moiety was added, resulting compounds exhibited not only potent CB1R activity but also a desired tPSA value over 90 A(2), a threshold considered to possess a low probability to cross BBB, leading to the identification of compound 4 (B/P = 1/64) as a peripherally restricted CB1R antagonist.	fusarubin	33-42	cannabinoid receptor 1 (brain)	Mus musculus	317-321
24157370-0	2013	The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.	fusarubin	4-13	zinc fingers and homeoboxes 2	Homo sapiens	120-123
24157370-0	2013	The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.	fusarubin	4-13	mitogen-activated protein kinase kinase 7	Homo sapiens	124-127
24128000-3	2013	Crystallographic studies on the complex of hCA II with the lead sulfamide derivative of this series clarified the binding mode of this type of inhibitors in the enzyme active site cavity.	fusarubin	64-73	carbonic anhydrase 2	Homo sapiens	43-49
24157370-1	2013	Introducing a sulfamide moiety to our coumarin derivatives afforded enhanced Raf/MEK inhibitory activity concomitantly with an acceptable PK profile.	fusarubin	14-23	zinc fingers and homeoboxes 2	Homo sapiens	77-80
24128000-5	2013	In vivo testing of the lead molecule in the sulfamide series, in cotreatment with doxorubicin, demonstrated a chemosensitization of CA IX containing tumors.	fusarubin	44-53	carbonic anhydrase 9	Homo sapiens	132-137
23707300-4	2013	We demonstrate that transcranial FUS application leads to a significant reduction in plaque burden four days after a single treatment in the TgCRND8 mouse model of AD and that endogenous antibodies are found bound to Abeta plaques.	fusarubin	33-36	amyloid beta (A4) precursor protein	Mus musculus	217-222
23474388-4	2013	Sulfamide 28 was identified as a highly potent MEK inhibitor with nanomolar cell potency against B-RAF (V600E) as well as Ras-mutated cell lines, high metabolic stability and resulting long half-lives.	fusarubin	0-9	mitogen-activated protein kinase kinase 7	Homo sapiens	47-50
23849171-7	2013	CONCLUSIONS: A newly designed nitroimidazole and sulfamide dual targeting drug reduces hypoxic extracellular acidification, slows down tumor growth at nontoxic doses and sensitizes tumors to irradiation all in a CAIX dependent manner, suggesting no "off-target" effects.	fusarubin	49-58	carbonic anhydrase 9	Homo sapiens	212-216
23543430-4	2013	Small-molecule BACE1 inhibitors of the hydroxyethylamine, hydantoin, and sulfamide classes were functionalized by biotin PEG linkers of varying lengths forming probes that were bound to streptavidin donor beads.	fusarubin	73-82	beta-secretase 1	Homo sapiens	15-20
23474388-4	2013	Sulfamide 28 was identified as a highly potent MEK inhibitor with nanomolar cell potency against B-RAF (V600E) as well as Ras-mutated cell lines, high metabolic stability and resulting long half-lives.	fusarubin	0-9	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	97-102
23200251-2	2013	CA VIII, X and XI thus obtained showed high catalytic activity (67.3-92.0% of the activity of hCA II and much higher compared to hCA I) and were inhibited in the milli-micromolar range by inorganic anions, sulfamide, sulfamic acid, phenylboronic acid and phenylarsonic acid.	fusarubin	206-215	carbonic anhydrase 8	Homo sapiens	0-7
23046583-13	2012	Accumulation of FUS in the cytoplasm may retain RNA targets and recruit additional RNA-binding proteins, such as PABP-1, into stress-granule like aggregates that coalesce into permanent inclusions that could negatively affect RNA metabolism.	fusarubin	16-19	poly(A) binding protein, cytoplasmic 1	Mus musculus	113-119
22921802-6	2012	We demonstrate that FUS can non-invasively deliver siRNA-Htt directly to the striatum leading to a significant reduction of Htt expression in a dose dependent manner.	fusarubin	20-23	huntingtin	Homo sapiens	57-60
22921802-6	2012	We demonstrate that FUS can non-invasively deliver siRNA-Htt directly to the striatum leading to a significant reduction of Htt expression in a dose dependent manner.	fusarubin	20-23	huntingtin	Homo sapiens	124-127
22984865-2	2012	Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize central nervous system (CNS) penetration by minimizing hydrogen bond donors (HBDs) and reducing P-glycoprotein (P-gp) mediated efflux.	fusarubin	87-96	beta-site APP cleaving enzyme 1	Mus musculus	54-60
22984865-2	2012	Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize central nervous system (CNS) penetration by minimizing hydrogen bond donors (HBDs) and reducing P-glycoprotein (P-gp) mediated efflux.	fusarubin	87-96	phosphoglycolate phosphatase	Mus musculus	247-261
22984865-2	2012	Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize central nervous system (CNS) penetration by minimizing hydrogen bond donors (HBDs) and reducing P-glycoprotein (P-gp) mediated efflux.	fusarubin	87-96	phosphoglycolate phosphatase	Mus musculus	263-267
21861133-7	2012	In summary, treatment with FUS, in combination with a dose of microbubbles, can enhance BBB permeability through a caveolae-mediated transcellular approach by upregulating the expression level of caveolin-1 and, consequently, the amount of caveolae.	fusarubin	27-30	caveolin 1	Rattus norvegicus	196-206
22506561-3	2012	The SAR for steroid inhibition of G6PD has been substantially developed; the 3beta-alcohol can be replaced with 3beta-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate.	fusarubin	140-149	sarcosine dehydrogenase	Homo sapiens	4-7
22506561-3	2012	The SAR for steroid inhibition of G6PD has been substantially developed; the 3beta-alcohol can be replaced with 3beta-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate.	fusarubin	140-149	glucose-6-phosphate dehydrogenase	Homo sapiens	34-38
22443542-10	2012	CONCLUSIONS: These data demonstrate that the overexpression of Fus/Caz causes in vivo toxicity by disrupting neuromuscular junctions (NMJs) and inducing apoptosis in motor neurons.	fusarubin	63-66	cabeza	Drosophila melanogaster	67-70
22355253-5	2012	Analysis according to gender did not show any influence of sex on the association of miR-146a and Ets-1 with FUS.	fusarubin	109-112	ETS proto-oncogene 1, transcription factor	Homo sapiens	98-103
19272776-2	2009	Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-activity relationships against HDAC1 and HDAC6 isotypes as well as 293T cells.	fusarubin	38-47	histone deacetylase 1	Homo sapiens	150-155
21875798-3	2011	Sulfonamide and sulfamide with high polar surface area and good activity at CB1 were rationally designed and pharmacologically tested.	fusarubin	16-25	cannabinoid receptor 1	Homo sapiens	76-79
20099854-3	2010	SUMO-AMSN (4a) and Ub-AMSN (4b) contain a sulfamide group as a nonhydrolyzable mimic of the phosphate group in the cognate Ub/Ubl-AMP adenylate intermediate in the first half-reaction, and these constructs selectively inhibit SUMO E1 and Ub E1, respectively, in a dose-dependent manner.	fusarubin	42-51	small nucleolar RNA, H/ACA box 73A	Homo sapiens	231-243
19272776-2	2009	Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-activity relationships against HDAC1 and HDAC6 isotypes as well as 293T cells.	fusarubin	38-47	histone deacetylase 6	Homo sapiens	160-165
17127063-7	2007	The best hCA VI inhibitors were cyanide, azide, sulfamide, and sulfamate, with inhibition constants in the range of 70-90microM.	fusarubin	48-57	carbonic anhydrase 6	Homo sapiens	9-15
17346964-5	2007	The additional two hydrogen bonds in which N-hydroxysulfamide bound to hCA II is involved as compared to the corresponding adduct of sulfamide may explain its higher affinity for the enzyme, also providing hints for the design of tight-binding CA inhibitors possessing an organic moiety substituting the NH group in the N-hydroxysulfamide structure.	fusarubin	52-61	carbonic anhydrase 2	Homo sapiens	71-77
18618322-5	2009	Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc.	fusarubin	193-202	carbonic anhydrase 1	Homo sapiens	42-47
18618322-5	2009	Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc.	fusarubin	193-202	HCA1	Homo sapiens	42-45
18217703-4	2008	An extensive SAR study led to sulfamide (R)- 22b, which inhibited the strand transfer with an IC50 of 7 nM and HIV infection in MT4 cells with a CIC95 of 44 nM, and ketoamide (S)- 28c that inhibited strand transfer with an IC50 of 12 nM and the HIV infection in MT4 cells with a CIC95 of 13 nM and exhibited a good pharmacokinetic profile when dosed orally to preclinical species.	fusarubin	30-39	sarcosine dehydrogenase	Homo sapiens	13-16
17627576-12	2007	Overview of analysis favours substituents with high electronegativity and less bulk at R and R" positions of the parent nucleus, provides a basis to design new Sulfamide derivatives possessing potent and selective carbonic anhydrase-II inhibitory activity.	fusarubin	160-169	carbonic anhydrase 2	Homo sapiens	214-235
17228882-0	2007	Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.	fusarubin	6-15	peroxisome proliferator activated receptor alpha	Rattus norvegicus	91-100
16999776-8	2006	From structure-activity comparisons, the sulfamate is more effective than the sulfamide in inhibiting carbonic anhydrase I and II, but the sulfamate does not confer selectivity.	fusarubin	78-87	carbonic anhydrase 1	Homo sapiens	102-129
17125255-1	2006	The sulfamide analogue of the antiepileptic drug topiramate is a 210 times less potent inhibitor of isozyme II of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) compared to topiramate but effectively inhibits isozymes CA VA, VB, VII, XIII, and XIV (KI in the range of 21-35 nM).	fusarubin	4-13	carbonic anhydrase 5A	Homo sapiens	223-228
17125255-3	2006	As shown by X-ray crystallography, the sulfamide analogue binds to CA II with the deprotonated sulfamide moiety coordinated to Zn(II) and with the organic scaffold making an extended network of hydrogen bonds with Thr199, Gln92, His94, Asn62, and Thr200.	fusarubin	39-48	carbonic anhydrase 2	Homo sapiens	67-72
17125255-3	2006	As shown by X-ray crystallography, the sulfamide analogue binds to CA II with the deprotonated sulfamide moiety coordinated to Zn(II) and with the organic scaffold making an extended network of hydrogen bonds with Thr199, Gln92, His94, Asn62, and Thr200.	fusarubin	95-104	carbonic anhydrase 2	Homo sapiens	67-72
16710859-3	2006	Among the enzymes for which sulfamide-based inhibitors were designed, are the carbonic anhydrases (CAs), a large number of proteases belonging to the aspartic protease (HIV-1 protease, gamma-secretase), serine protease (elastase, chymase, tryptase, and thrombin among others), and metalloprotease (carboxypeptidase A (CPA) and matrix metalloproteinases (MMP)) families.	fusarubin	28-37	carboxypeptidase A1	Homo sapiens	318-321
16710859-4	2006	Some steroid sulfatase (STS) and protein tyrosine phosphatase inhibitors belonging to the sulfamide class of derivatives have also been reported.	fusarubin	90-99	steroid sulfatase	Homo sapiens	5-22
16759092-0	2006	Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.	fusarubin	53-62	carbonic anhydrase 2	Homo sapiens	14-35
16759092-1	2006	This paper examines the relative effectiveness of bioisosteric sulfamate and sulfamide derivatives for inhibition of human carbonic anhydrase-II (CA-II) by using a direct binding assay based on the ThermoFluor method (Matulis et al.	fusarubin	77-86	carbonic anhydrase 2	Homo sapiens	123-144
16759092-1	2006	This paper examines the relative effectiveness of bioisosteric sulfamate and sulfamide derivatives for inhibition of human carbonic anhydrase-II (CA-II) by using a direct binding assay based on the ThermoFluor method (Matulis et al.	fusarubin	77-86	carbonic anhydrase 2	Homo sapiens	146-151
16759092-11	2006	It appears that the sulfamide group is less suitable than the sulfamate group for obtaining potent inhibition of CA-II.	fusarubin	20-29	carbonic anhydrase 2	Homo sapiens	113-118
16311805-0	2005	Alternative method of Boc-removal from sulfamide using silica-phenyl sulfonic acid in conjunction with microwave heating.	fusarubin	39-48	BOC cell adhesion associated, oncogene regulated	Homo sapiens	22-25
20141508-2	2006	Amongst the enzymes for which sulfamide-based inhibitors were designed are the carbonic anhydrases (CAs), and a large number of proteases belonging to the aspartic protease (HIV-1 protease, gamma-secretase), serine protease (elastase, chymase, tryptase and thrombin, among others) and metalloproteinase (carboxypeptidase A [CPA] and matrix metalloproteinase [MMP]) families.	fusarubin	30-39	carboxypeptidase A1	Homo sapiens	324-327
20141508-3	2006	Some steroid sulfatase (STS) and protein tyrosine phosphatase inhibitors belonging to the sulfamide class of derivatives have also been reported.	fusarubin	90-99	steroid sulfatase	Homo sapiens	5-22
20141508-5	2006	This is achieved either by directly coordinating to the metal ion found in some metalloenzymes (CAs, CPA, STS), usually by means of one of the nitrogen atoms present in the sulfamide motif, or, as in the case of the cyclic sulfamides, acting as HIV protease inhibitors interacting with the catalytically critical aspartic acid residues of the active site by means of an oxygen atom belonging to the HN-SO(2)-NH motif that substitutes a catalytically essential water molecule.	fusarubin	173-182	carboxypeptidase A1	Homo sapiens	101-104
15771438-0	2005	Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.	fusarubin	28-37	carbonic anhydrase 2	Homo sapiens	67-88
15771438-1	2005	This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).	fusarubin	64-73	carbonic anhydrase 2	Homo sapiens	103-124
15771438-1	2005	This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).	fusarubin	64-73	carbonic anhydrase 2	Homo sapiens	126-131
15686897-1	2005	The identification, design, and synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Ralpha are described.	fusarubin	63-72	interleukin 2	Homo sapiens	151-155
15686897-1	2005	The identification, design, and synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Ralpha are described.	fusarubin	63-72	interleukin 2 receptor subunit alpha	Homo sapiens	156-166
15686897-2	2005	Installation of a furan carboxylic acid fragment onto a low-micromolar sulfamide resulted in a 23-fold improvement in activity, providing a sub-micromolar, nonpeptidic IL-2 inhibitor (IC(50)=0.60 microM).	fusarubin	71-80	interleukin 2	Homo sapiens	168-172
15454240-2	2004	The inhibition of the newly discovered cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isozyme XIII of murine origin (mCA XIII) has been investigated with a series of anions, such as the physiological ones (bicarbonate, chloride), or the metal complexing anions (cyanate, cyanide, azide, hydrogen sulfide, etc), nitrate, nitrite, sulfate, sulfamate, sulfamide as well as with phenylboronic and phenylarsonic acids.	fusarubin	348-357	carbonic anhydrase 13	Mus musculus	116-124
15501038-5	2004	Excellent hCA IV inhibitory properties showed sulfamic acid, sulfamide, phenylboronic acid and phenylarsonic acid, with K(i)"s in the range of 0.87-0.93 microM, whereas their affinities for the other investigated isozymes were in the millimolar range.	fusarubin	61-70	carbonic anhydrase 4	Homo sapiens	10-16
15454240-3	2004	The best mCA XIII inhibitors were cyanate, thiocyanate, cyanide and sulfamide, with K(I)-s in the range of 0.25microM-0.74 mM, whereas fluoride, iodide, azide, carbonate and hydrogen sulfide were less effective (K(I)-s in the range of 3.0-5.5mM).	fusarubin	68-77	carbonic anhydrase 13	Mus musculus	9-17
12431056-0	2002	Sulfamide-based inhibitors for carboxypeptidase A.	fusarubin	0-9	carboxypeptidase A1	Homo sapiens	31-49
12904065-5	2003	The sulfamide and sulfonamide derivatization at the N-terminal position in general afforded highly potent thrombin inhibitors but with moderate oral absorption, while the well-absorbable N-carbamate derivatives exhibited limited metabolic stability in S9 fractions.	fusarubin	4-13	coagulation factor II	Rattus norvegicus	106-114
15231731-3	2004	Based on cDNA microarrays and protein analysis, we found that FUS at the intermediate peak pressure of 1.5 MPa induced a complex signaling cascade with upregulation of proapoptotic genes [e.g., p53, p21, Thy1 (CD 90)].	fusarubin	62-65	tumor protein p53	Homo sapiens	194-197
15231731-3	2004	Based on cDNA microarrays and protein analysis, we found that FUS at the intermediate peak pressure of 1.5 MPa induced a complex signaling cascade with upregulation of proapoptotic genes [e.g., p53, p21, Thy1 (CD 90)].	fusarubin	62-65	H3 histone pseudogene 16	Homo sapiens	199-202
15231731-3	2004	Based on cDNA microarrays and protein analysis, we found that FUS at the intermediate peak pressure of 1.5 MPa induced a complex signaling cascade with upregulation of proapoptotic genes [e.g., p53, p21, Thy1 (CD 90)].	fusarubin	62-65	Thy-1 cell surface antigen	Homo sapiens	204-208
15231731-3	2004	Based on cDNA microarrays and protein analysis, we found that FUS at the intermediate peak pressure of 1.5 MPa induced a complex signaling cascade with upregulation of proapoptotic genes [e.g., p53, p21, Thy1 (CD 90)].	fusarubin	62-65	Thy-1 cell surface antigen	Homo sapiens	210-215
15231731-4	2004	Simultaneously, FUS downregulated cellular survival components (e.g., bcl-2, SOD).	fusarubin	16-19	BCL2 apoptosis regulator	Homo sapiens	70-75
15080932-0	2004	Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A.	fusarubin	0-9	carboxypeptidase A1	Homo sapiens	66-84
12617903-1	2003	A novel class of effective CAIs has been identified, starting from a very weak carbonic anhydrase inhibitor (CAI), sulfamide, whose X-ray crystal structure in the adduct with hCA II has recently been reported.	fusarubin	115-124	carbonic anhydrase 2	Homo sapiens	175-181
12617904-1	2003	A series of sugar sulfamate/sulfamide derivatives were prepared and assayed as inhibitors of three carbonic anhydrase (CA) isozymes, hCA I, hCA II and bCA IV.	fusarubin	28-37	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	133-157
11731425-10	2001	Immunohistochemistry of the resected specimen demonstrated that FUS homogeneously induced lethal and sublethal tumor damage with consecutive up-regulation of p53 and loss of proliferative activity.	fusarubin	64-67	tumor protein p53	Homo sapiens	158-161
12362982-0	2002	Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.	fusarubin	0-9	thymidylate synthase	Mus musculus	33-53
10560733-0	1999	4-Chlorobenzyl sulfonamide and sulfamide derivatives of histamine homologues: the design of potent histamine H3 receptor antagonists.	fusarubin	31-40	histamine receptor H3	Homo sapiens	99-120
11916140-4	2001	The new sulfamide/sulfamates were effective CA II and CA IV inhibitors, but showed no inhibitory activity against isozyme I.	fusarubin	8-17	carbonic anhydrase 2	Homo sapiens	44-49
11916140-4	2001	The new sulfamide/sulfamates were effective CA II and CA IV inhibitors, but showed no inhibitory activity against isozyme I.	fusarubin	8-17	carbonic anhydrase 4	Homo sapiens	54-59
33799460-5	2021	Congeners with attached sulfamide substituents retained Aurora A inhibitory activity.	fusarubin	24-33	aurora kinase A	Homo sapiens	56-64
10507774-5	1999	In patients treated with fluorouracil derivatives (FUs), the expression of TP significantly correlated with favourable prognosis and with unfavourable prognosis in those not treated with FUs.	fusarubin	51-54	thymidine phosphorylase	Homo sapiens	75-77
10507774-5	1999	In patients treated with fluorouracil derivatives (FUs), the expression of TP significantly correlated with favourable prognosis and with unfavourable prognosis in those not treated with FUs.	fusarubin	187-190	thymidine phosphorylase	Homo sapiens	75-77
10507774-6	1999	The patients with TP-positive tumours, the prognosis of patients treated with FUs was significantly better than that of those not treated with FUs.	fusarubin	78-81	thymidine phosphorylase	Homo sapiens	18-20
10507774-6	1999	The patients with TP-positive tumours, the prognosis of patients treated with FUs was significantly better than that of those not treated with FUs.	fusarubin	143-146	thymidine phosphorylase	Homo sapiens	18-20
10507774-7	1999	In patients with TP-positive tumours, treatment with FUs and lymph node metastasis were independent prognostic factors according to the Cox proportional hazards model.	fusarubin	53-56	thymidine phosphorylase	Homo sapiens	17-19
10507774-9	1999	The determination of the expression of TP might be useful for predicting the efficacy of post-operative chemotherapy using FUs to prevent recurrence in advanced gastric carcinoma patients who undergo curative gastrectomy.	fusarubin	123-126	thymidine phosphorylase	Homo sapiens	39-41
9083478-2	1997	The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1" and P2" side chains were transposed.	fusarubin	123-132	crystallin gamma F, pseudogene	Homo sapiens	186-196
34605896-0	2022	FUS-induced neurotoxicity is prevented by inhibiting GSK-3beta in a drosophila model of amyotrophic lateral sclerosis.	fusarubin	0-3	shaggy	Drosophila melanogaster	53-62
34734364-10	2022	By 2 weeks post-FUS, we noted emergence of adaptive resistance mechanisms, including upregulation of TIGIT on CD4 + T cells and CD155 on non-immune tumor and stromal cells.	fusarubin	16-19	T cell immunoreceptor with Ig and ITIM domains	Mus musculus	101-106
34734364-10	2022	By 2 weeks post-FUS, we noted emergence of adaptive resistance mechanisms, including upregulation of TIGIT on CD4 + T cells and CD155 on non-immune tumor and stromal cells.	fusarubin	16-19	CD4 antigen	Mus musculus	110-113
34530052-5	2021	In vitro studies demonstrated sustained release of basic fibroblast growth factor (bFGF) from the ARSs using repeated applications of FUS.	fusarubin	134-137	fibroblast growth factor 2	Mus musculus	51-81
34530052-5	2021	In vitro studies demonstrated sustained release of basic fibroblast growth factor (bFGF) from the ARSs using repeated applications of FUS.	fusarubin	134-137	fibroblast growth factor 2	Mus musculus	83-87
34605896-5	2022	Here, we report GSK-3beta as a potential modulator of FUS-induced toxicity.	fusarubin	54-57	shaggy	Drosophila melanogaster	16-25
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	41-44	supernumerary limbs	Drosophila melanogaster	105-110
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	41-44	supernumerary limbs	Drosophila melanogaster	170-175
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	41-44	shaggy	Drosophila melanogaster	218-234
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	132-135	supernumerary limbs	Drosophila melanogaster	105-110
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	132-135	supernumerary limbs	Drosophila melanogaster	170-175
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	132-135	shaggy	Drosophila melanogaster	218-234
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	249-252	supernumerary limbs	Drosophila melanogaster	105-110
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	249-252	supernumerary limbs	Drosophila melanogaster	170-175
34605896-8	2022	In addition, we found that the levels of FUS proteins were significantly reduced by co-overexpression of Slimb, a F-box protein, in FUS-expressing flies, indicating that Slimb is critical for the suppressive effect of Shaggy/GSK-3beta inhibition on FUS-induced toxicity in Drosophila.	fusarubin	249-252	shaggy	Drosophila melanogaster	218-234
34605896-9	2022	These findings revealed a novel mechanism of neuronal protective effect through SCFSlimb-mediated FUS degradation via GSK-3beta inhibition, and provided in vivo evidence of the potential for modulating FUS-induced ALS progression using GSK-3beta inhibitors.	fusarubin	98-101	shaggy	Drosophila melanogaster	118-127
34605896-9	2022	These findings revealed a novel mechanism of neuronal protective effect through SCFSlimb-mediated FUS degradation via GSK-3beta inhibition, and provided in vivo evidence of the potential for modulating FUS-induced ALS progression using GSK-3beta inhibitors.	fusarubin	202-205	shaggy	Drosophila melanogaster	236-245
35179290-3	2022	Since sulfamide realizes the optimal balance in the relationships among composition, structure, and properties, in addition to very short absorption of 160 nm, it achieves multiple optical performance records among the non-pi-conjugated DUV NLO materials, including the strongest SHG efficiency (about 4 times that of KDP), the largest birefringence (obv.	fusarubin	6-15	WNK lysine deficient protein kinase 1	Homo sapiens	318-321
34405679-3	2021	Here, we developed a kind of nanoprobe-loaded MBs (AV-ICG-NPs@MBs) which can monitor the apoptotic cells that occur during FUS-mediated BBB opening through encapsulating the annexin V-targeted nanoprobes AV-ICG-NPs into the cavity of lipid-PLGA hybrid MBs.	fusarubin	123-126	annexin A5	Homo sapiens	174-183
34393708-6	2021	The water diffusion caused by FUS-BBBD was analyzed using the apparent diffusion coefficient (ADC), axial diffusivity, radial diffusivity (RD), and fractional anisotropy, obtained at 5 min, 24 and 48 h, as well as the water channel expression of aquaporin-4 (AQP-4) immunostaining at 48 h after FUS-induced BBBD.	fusarubin	30-33	aquaporin 4	Rattus norvegicus	246-257
34393708-6	2021	The water diffusion caused by FUS-BBBD was analyzed using the apparent diffusion coefficient (ADC), axial diffusivity, radial diffusivity (RD), and fractional anisotropy, obtained at 5 min, 24 and 48 h, as well as the water channel expression of aquaporin-4 (AQP-4) immunostaining at 48 h after FUS-induced BBBD.	fusarubin	30-33	aquaporin 4	Rattus norvegicus	259-264
34393708-9	2021	When we applied higher sonication conditions, the ADC and RD showed enhancement until 48 h, and became comparable to contralateral values at 72 h. AQP-4 expression was upregulated after FUS-induced BBBD in both sonication conditions at 48 h. The results of this study provide preliminary evidence on how mechanical forces from FUS alter water dynamics through diffusion tensor imaging (DTI) measures and AQP4 expression.	fusarubin	186-189	aquaporin 4	Rattus norvegicus	147-152
34393708-9	2021	When we applied higher sonication conditions, the ADC and RD showed enhancement until 48 h, and became comparable to contralateral values at 72 h. AQP-4 expression was upregulated after FUS-induced BBBD in both sonication conditions at 48 h. The results of this study provide preliminary evidence on how mechanical forces from FUS alter water dynamics through diffusion tensor imaging (DTI) measures and AQP4 expression.	fusarubin	186-189	aquaporin 4	Rattus norvegicus	404-408
34393708-9	2021	When we applied higher sonication conditions, the ADC and RD showed enhancement until 48 h, and became comparable to contralateral values at 72 h. AQP-4 expression was upregulated after FUS-induced BBBD in both sonication conditions at 48 h. The results of this study provide preliminary evidence on how mechanical forces from FUS alter water dynamics through diffusion tensor imaging (DTI) measures and AQP4 expression.	fusarubin	327-330	aquaporin 4	Rattus norvegicus	147-152
34393708-9	2021	When we applied higher sonication conditions, the ADC and RD showed enhancement until 48 h, and became comparable to contralateral values at 72 h. AQP-4 expression was upregulated after FUS-induced BBBD in both sonication conditions at 48 h. The results of this study provide preliminary evidence on how mechanical forces from FUS alter water dynamics through diffusion tensor imaging (DTI) measures and AQP4 expression.	fusarubin	327-330	aquaporin 4	Rattus norvegicus	404-408
6761818-0	1982	[Medium term effect (3 months) of hypoglycemic sulfamide treatment (gliclazide) on insulin secretion of the non-insulin dependent diabetic].	fusarubin	47-56	insulin	Homo sapiens	83-90
6761818-0	1982	[Medium term effect (3 months) of hypoglycemic sulfamide treatment (gliclazide) on insulin secretion of the non-insulin dependent diabetic].	fusarubin	47-56	insulin	Homo sapiens	112-119
33989819-10	2021	FUS stimulation of TRPV1-expressing neurons at the striatum repeatedly evoked locomotor behavior in freely moving mice.	fusarubin	0-3	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
33600879-7	2021	Following FUS-triggered delivery, sham nanodroplets induced a 22.6 +- 21% increase in local c-Fos expression, whereas pentobarbital-loaded nanodroplets induced a 21.7 +- 13% decrease (n = 6).	fusarubin	10-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
33992926-4	2021	Several compounds showed good inhibition of PDE4B in vitro and the SAR indicated superiority of aminosulfonamide moiety over aminocarboxamide in terms of PDE4B inhibition.	fusarubin	96-112	phosphodiesterase 4B, cAMP-specific a	Danio rerio	44-49
33992926-4	2021	Several compounds showed good inhibition of PDE4B in vitro and the SAR indicated superiority of aminosulfonamide moiety over aminocarboxamide in terms of PDE4B inhibition.	fusarubin	96-112	phosphodiesterase 4B, cAMP-specific a	Danio rerio	154-159
33992926-6	2021	The participation of aminosulfonamide moiety in PDE4B inhibition and the reason for selectivity though moderate shown by 3q and 3u was revealed by the in silico docking studies.	fusarubin	21-37	phosphodiesterase 4B, cAMP-specific a	Danio rerio	48-53
33608142-5	2021	A 40% increase in accumulation of transferrin receptor-targeting liposomes was observed in the FUS-treated hemisphere, whereas the isotype immunoglobulin G liposomes showed no increased accumulation.	fusarubin	95-98	transferrin receptor	Rattus norvegicus	34-54
33476735-4	2021	We demonstrate that timing of antibody injection relative to FUS BBB/BTB disruption is a critical determinant of mCD47 access, with post-FUS injection conferring superlative antibody delivery to gliomas.	fusarubin	61-64	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	113-118
33476735-5	2021	We also show that mCD47 delivery across the BBB/BTB with repeat sessions of FUS can significantly constrain tumor outgrowth and extend survival in glioma-bearing mice.	fusarubin	76-79	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	18-23
33476735-7	2021	Moreover, our results confirm that mCD47 delivery with FUS is a promising therapeutic strategy for GB therapy.	fusarubin	55-58	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	35-40
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	vascular endothelial growth factor A	Homo sapiens	75-79
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	fibroblast growth factor 2	Homo sapiens	81-85
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	interleukin 6	Homo sapiens	87-91
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	interleukin 10	Homo sapiens	102-107
33393538-1	2021	The regioselective gamma-C-H amination of the side-chain of saturated 2-alkyl nitrogen heterocycles is reported, proceeding through a sulfamide-directed 1,6-radical translocation.	fusarubin	134-143	interleukin 2 receptor subunit gamma	Homo sapiens	19-26
33447034-9	2021	Furthermore, the FUS-assisted MBs-LPHNspCas9/MGMT-cRGD enhanced the therapeutic effects of TMZ in glioblastoma, inhibited tumor growth, and prolonged survival of tumor-bearing mice, with a high level of biosafety.	fusarubin	17-20	O-6-methylguanine-DNA methyltransferase	Mus musculus	45-49
33287379-5	2020	FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation.	fusarubin	0-3	caveolin 2	Homo sapiens	4-7