PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27798822-2	2017	Cytochrome P450 BM3 L188P A328F (BM3 PF) and A74E L188P A328F (BM3 EPF) variants are able to efficiently oxidize n-butane to 2-butanol.	2-butanol	125-134	heat shock protein family E (Hsp10) member 1	Homo sapiens	67-70
25054226-6	2014	A key factor for the production of 2-butanol was the availability of NADH, which was achieved by growing cells lacking the GPD1 and GPD2 isogenes under anaerobic conditions.	2-butanol	35-44	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	123-127
27689355-12	2016	RESULTS: Biomarkers, Apo AIV and citrulline showed a significant correlation with RSBL in aSBS patients.	2-butanol	90-94	apolipoprotein A4	Homo sapiens	21-28
27689355-15	2016	ROC analysis indicated the Apo AIV cut-off value to be 4.6 mg /100 mL for differentiating between the aSBS HPN and ORAL groups.	2-butanol	102-106	apolipoprotein A4	Homo sapiens	27-34
25054226-6	2014	A key factor for the production of 2-butanol was the availability of NADH, which was achieved by growing cells lacking the GPD1 and GPD2 isogenes under anaerobic conditions.	2-butanol	35-44	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	132-136
23282041-7	2013	Accordingly they showed an increased Fos expression in POM after ASB but not CSB tests.	2-butanol	65-68	proto-oncogene c-Fos	Coturnix japonica	37-40
25434188-1	2013	There was studied action of aliphatic alcohols (ethanol, propanol, isopropanol, n-butanol, isobutanol, secbutanol, tretbetanol) and pH on various kinds of reactional capability the serum cholinesterase.	2-butanol	103-113	butyrylcholinesterase	Homo sapiens	187-201
20729283-10	2010	Circulating IGF-I concentrations declined from 2 to 6 d postchallenge and increased again by d 13 in ASB and LP groups, did not decline in FSM and CT groups, and continuously declined through d 13 in CON and LP groups (P < 0.05).	2-butanol	101-104	insulin like growth factor 1	Sus scrofa	12-17
23662182-5	2013	1-Butanol, the quencher of PLD, generated PA leading to the formation of physiologically inactive phosphatidyl butanol but not its biologically inactive analog, 2-butanol, blocked the H2O2-mediated barrier dysfunction.	2-butanol	161-170	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
19789852-8	2009	Inhibition of phospholipase D and protein kinase C-beta by 2-butanol and LY373196 respectively reduced TGF-beta1, SMAD2/3 phosphorylation and fibronectin production.	2-butanol	59-68	transforming growth factor, beta 1	Mus musculus	103-112
15260334-5	2004	The main influence of the scavenger arises from its independent production of HO2 radicals, with CO producing the most HO2, 2-butanol an intermediate amount, and cyclohexane the least.	2-butanol	124-133	heme oxygenase 2	Homo sapiens	78-81
17516063-7	2007	N. crassa ADH1 preferred primary alcohols containing C3-C8 carbons to secondary alcohols such as 2-propanol and 2-butanol.	2-butanol	112-121	alcohol dehydrogenase I	Neurospora crassa OR74A	10-14
17294384-4	2007	RESULTS: Mean threshold registered by MP1 microperimeter was 19.7+/-0.8 dB (range 16-20 dB; 4.38+/-0.96 asb, range 4-10 asb) versus 33.1+/-1.7 dB (range 27-38 dB; 0.53+/-0.22 asb, range 0.16-2 asb) obtained with Octopus perimeter.	2-butanol	104-107	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Homo sapiens	38-41
15525798-2	2005	Ang II-induced Akt phosphorylation was significantly reduced by the PLD inhibitor 1-butanol, but not by its inactive analog 2-butanol, and by brefeldin A, an inhibitor of the PLD cofactor ADP-ribosylation factor, and in cells infected with retrovirus containing PLD(2) siRNA or transfected with PLD(2) antisense but not control LacZ or sense oligonucleotide.	2-butanol	124-133	angiotensinogen	Rattus norvegicus	0-6
15525798-2	2005	Ang II-induced Akt phosphorylation was significantly reduced by the PLD inhibitor 1-butanol, but not by its inactive analog 2-butanol, and by brefeldin A, an inhibitor of the PLD cofactor ADP-ribosylation factor, and in cells infected with retrovirus containing PLD(2) siRNA or transfected with PLD(2) antisense but not control LacZ or sense oligonucleotide.	2-butanol	124-133	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
10582613-6	1999	Platelet-derived growth factor and endothelin-1 mimicked the mitogenic effect of FCS; their effects were also inhibited by the butanols in the potency order 1-butanol > 2-butanol > tert-butanol.	2-butanol	172-181	endothelin 1	Rattus norvegicus	35-47
14528019-9	2004	Spo14p-generated PtdOH appears to have an essential role in sporulation, because treatment of cells with 1-butanol, which supports Spo14p-catalyzed PtdCho breakdown but leads to production of Cho and Ptd-butanol, blocks spore formation at concentrations where the inert isomer, 2-butanol, has little effect.	2-butanol	278-287	phospholipase D	Saccharomyces cerevisiae S288C	0-6
14528019-9	2004	Spo14p-generated PtdOH appears to have an essential role in sporulation, because treatment of cells with 1-butanol, which supports Spo14p-catalyzed PtdCho breakdown but leads to production of Cho and Ptd-butanol, blocks spore formation at concentrations where the inert isomer, 2-butanol, has little effect.	2-butanol	278-287	phospholipase D	Saccharomyces cerevisiae S288C	131-137
9268538-1	1997	Aluminum sec-butoxide was chelated with a beta-diketoester in different molar ratios.	2-butanol	0-21	amyloid beta precursor protein	Homo sapiens	40-46
2155346-2	1990	Vitamin D or its metabolites are dissolved in 100 microliters methanol and 10 M HC1 in 2-butanol is used as the reagent for isomerization.	2-butanol	87-96	CYCS pseudogene 39	Homo sapiens	80-83
4015835-2	1985	The reconstituted alcohol-P-450 oxygenase (APO) system containing P-450ALC and NADPH-cytochrome P-450 reductase catalyzes the oxidation of a variety of primary and secondary alcohols to aldehydes and ketones, including methanol, ethanol, n-propanol, n-butanol, 2-butanol, n-pentanol, and cyclohexanol.	2-butanol	261-270	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	79-111
2507790-7	1989	The most marked potentiation of CCl4 hepatotoxicity occurred when rats were pretreated with 2-butanol or 2-butanone 16 h before CCl4 administration.	2-butanol	92-101	C-C motif chemokine ligand 4	Rattus norvegicus	32-36
2507790-7	1989	The most marked potentiation of CCl4 hepatotoxicity occurred when rats were pretreated with 2-butanol or 2-butanone 16 h before CCl4 administration.	2-butanol	92-101	C-C motif chemokine ligand 4	Rattus norvegicus	128-132
32510099-2	2020	Mixing (R)- and (S)-2-butanol with an alpha-CD/HFIP solution realized (S)-2-butanol-selective organogel formation.	2-butanol	16-29	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-46
6095901-0	1984	Stereochemical studies on the cytochrome P-450 and hydroxyl radical dependent pathways of 2-butanol oxidation by microsomes from chow-fed, phenobarbital-treated, and ethanol-treated rats.	2-butanol	90-99	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	30-46
6095901-6	1984	2-Butanol appears to be a particularly good alcohol substrate for the cytochrome P-450 dependent pathway of alcohol oxidation.	2-butanol	0-9	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	70-86
3938271-2	1985	sec-Butanol caused the highest increase in cytochrome P-450 concentration with a 47% rise in the kidneys (500 ppm for 5 days) and 33% in the liver (2000 ppm for 3 days).	2-butanol	0-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
3938271-7	1985	As a conclusion sec-butanol, probably through its metabolite methyl-ethyl-ketone, is the most potent inducer of microsomal cytochrome P-450 in liver and kidney while iso-butanol does not alter total cytochrome P-450.	2-butanol	16-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	123-139
3938271-7	1985	As a conclusion sec-butanol, probably through its metabolite methyl-ethyl-ketone, is the most potent inducer of microsomal cytochrome P-450 in liver and kidney while iso-butanol does not alter total cytochrome P-450.	2-butanol	16-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	199-215
1255493-1	1976	The role of alcohol metabolism in 2-butanol-induced potentiation of carbon tetrachloride (CCl4) hepatotoxicity was studied in rats.	2-butanol	34-43	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
32510099-2	2020	Mixing (R)- and (S)-2-butanol with an alpha-CD/HFIP solution realized (S)-2-butanol-selective organogel formation.	2-butanol	70-83	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-46