PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31175940-0	2019	Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader.	Sesterterpenes	0-13	estrogen receptor 1	Homo sapiens	61-78
29185768-1	2017	Heterologous expression of four clade-A bifunctional terpene synthases (BFTSs), giving di/sesterterpenes with unique polycyclic carbon skeletons such as sesterfisherol, enabled the isolation of the sesterterpenes Bm1, Bm2, Bm3, and Pb1.	Sesterterpenes	90-104	submaxillary gland androgen regulated protein 3A	Homo sapiens	232-235
27285057-2	2016	While the biosynthesis of cyclic monoterpenes (C10) and sesquiterpenes (C15) most often involves enzymes with alpha or alphabeta domain architecture, the biosynthesis of cyclic diterpenes (C20), sesterterpenes (C25), and triterpenes (C30) can involve enzymes with alpha, alphaalpha, betagamma, or alphabetagamma domain architecture.	Sesterterpenes	195-209	homeobox C10	Homo sapiens	47-50
27285057-2	2016	While the biosynthesis of cyclic monoterpenes (C10) and sesquiterpenes (C15) most often involves enzymes with alpha or alphabeta domain architecture, the biosynthesis of cyclic diterpenes (C20), sesterterpenes (C25), and triterpenes (C30) can involve enzymes with alpha, alphaalpha, betagamma, or alphabetagamma domain architecture.	Sesterterpenes	195-209	placenta associated 8	Homo sapiens	72-75
23656455-2	2013	Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR).	Sesterterpenes	42-55	nuclear receptor subfamily 1 group H member 4	Homo sapiens	108-128
26168137-4	2015	Interestingly, ppt1 mutants of C. miyabeanus were shown to produce tenfold higher levels of the sesterterpene-type non-HST ophiobolin A, as compared with the wild-type strain.	Sesterterpenes	96-109	plastid phosphate/phosphoenolpyruvate translocator 1	Zea mays	15-19
25748161-0	2015	3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of alpha-synuclein in PC12 cells.	Sesterterpenes	43-56	synuclein alpha	Rattus norvegicus	129-144
25251727-0	2014	Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor.	Sesterterpenes	10-24	TAR DNA binding protein	Homo sapiens	67-73
23944963-3	2013	Two new sesterterpenes, thorectidaeolide A (1) and 4-acetoxythorectidaeolide A (2), and luffariellolide (11) were among the most potent inhibitors of hypoxia (1% O2)-induced HIF-1 activation (IC50 values of 3.2, 3.5, and 3.6 muM, respectively).	Sesterterpenes	8-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	174-179
23944963-3	2013	Two new sesterterpenes, thorectidaeolide A (1) and 4-acetoxythorectidaeolide A (2), and luffariellolide (11) were among the most potent inhibitors of hypoxia (1% O2)-induced HIF-1 activation (IC50 values of 3.2, 3.5, and 3.6 muM, respectively).	Sesterterpenes	8-22	latexin	Homo sapiens	225-228
23656455-2	2013	Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR).	Sesterterpenes	42-55	nuclear receptor subfamily 1 group H member 4	Homo sapiens	130-133
18330714-0	2008	Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis.	Sesterterpenes	28-42	fibroblast growth factor 2	Homo sapiens	74-79
19814997-0	2010	Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death.	Sesterterpenes	24-37	tumor necrosis factor	Homo sapiens	48-57
19814997-0	2010	Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death.	Sesterterpenes	24-37	nuclear factor kappa B subunit 1	Homo sapiens	66-76
12325001-7	2002	Similar results in terms of the reaction profile, mass increments, and location of the PLA(2) binding site were obtained for manoalide, a paradigm for irreversible PLA(2) inhibitors, which suggests that the present results may be considered of more general interest within the field of anti-inflammatory sesterterpenes that contain the gamma-hydroxybutenolide pharmacophore.	Sesterterpenes	304-318	phospholipase A2 group IB	Homo sapiens	87-93
17407277-1	2007	As a part of our drug discovery effort, recently we clarified the molecular basis of phospholipase A2 (PLA2) inactivation by petrosaspongiolide M (PM), an interesting metabolite belonging to a marine sesterterpene family, containing in its structural architecture a gamma-hydroxybutenolide moiety and showing potent anti-inflammatory activity.	Sesterterpenes	200-213	phospholipase A2 group IB	Homo sapiens	85-101
17407277-1	2007	As a part of our drug discovery effort, recently we clarified the molecular basis of phospholipase A2 (PLA2) inactivation by petrosaspongiolide M (PM), an interesting metabolite belonging to a marine sesterterpene family, containing in its structural architecture a gamma-hydroxybutenolide moiety and showing potent anti-inflammatory activity.	Sesterterpenes	200-213	phospholipase A2 group IB	Homo sapiens	103-107
17988093-0	2007	Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity.	Sesterterpenes	10-24	nuclear receptor subfamily 1 group H member 4	Homo sapiens	77-80
11529765-2	2001	An intramolecular [2 + 2]-photocycloaddition is used to provide a photoadduct, which upon fragmentation, lactone cleavage, and subsequent Cope rearrangement provides a dicyclopenta[a,d]cyclooctene ring system with substituents in place (e.g., C3 and C11) to access several 5-8-5 diterpene and sesterterpene natural products.	Sesterterpenes	293-306	RNA polymerase III subunit K	Homo sapiens	250-253
10698708-1	2000	We investigated the effect of cyclolinteinone, a sesterterpene from Caribbean sponge Cacospongia linteiformis, on inducible NO synthase (iNOS) and cyclo-oxygenase-2 (COX-2) protein expression in lipopolysaccharide (LPS)-stimulated J774 macrophages.	Sesterterpenes	49-62	nitric oxide synthase 2, inducible	Mus musculus	137-141
34992039-0	2022	Design and synthesis of marine sesterterpene analogues as novel estrogen receptor alpha degraders for breast cancer treatment.	Sesterterpenes	31-44	estrogen receptor 1	Homo sapiens	64-87
34992039-2	2022	The marine sesterterpene compound MHO7 had been reported to be a potential ERalpha degradation agent.	Sesterterpenes	11-24	estrogen receptor 1	Homo sapiens	75-82
1562564-1	1992	Rat testicular and adrenal gland microsomal preparations were incubated with 23,24-dinor-5-cholen-3 beta-ol (Guneribol) a proposed intermediate in the sesterterpene pathway for steroid biosynthesis.	Sesterterpenes	151-164	integrin subunit beta 1	Rattus norvegicus	100-107