PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 29687583-2 2018 We tested the hypothesis that regular LCS consumption is associated with higher postprandial glucose-dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity. lcs 38-41 gastric inhibitory polypeptide Homo sapiens 93-137 10230875-2 1999 In this study, we examined whether LcS can induce the production of interleukin (IL)-12 and interferon-gamma (IFN-gamma), which are important cytokines for antitumor and antimicrobial immunity, from murine splenocytes in vitro in order to clarify the mechanisms of its immune modification. lcs 35-38 interferon gamma Mus musculus 92-108 10230875-2 1999 In this study, we examined whether LcS can induce the production of interleukin (IL)-12 and interferon-gamma (IFN-gamma), which are important cytokines for antitumor and antimicrobial immunity, from murine splenocytes in vitro in order to clarify the mechanisms of its immune modification. lcs 35-38 interferon gamma Mus musculus 110-119 10230875-3 1999 Stimulation by LcS induced a marked production of IL-12 by X-ray-irradiated splenocytes (X-irr-Spl). lcs 15-18 plasma serotonin level Mus musculus 95-98 10230875-6 1999 LcS showed a synergistic stimulatory effect on the ConA-induced production of IFN-gamma. lcs 0-3 interferon gamma Mus musculus 78-87 10230875-11 1999 Furthermore, in BALB/c mice, the oral administration of viable LcS augmented the production of IFN-gamma but not that of IL-4 or IL-5 by splenocytes. lcs 63-66 interferon gamma Mus musculus 95-104 9704862-5 1998 administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival. lcs 18-21 interferon gamma Mus musculus 92-101 9704862-5 1998 administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival. lcs 18-21 interleukin 1 beta Mus musculus 103-111 9704862-5 1998 administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival. lcs 18-21 tumor necrosis factor Mus musculus 116-125 8040620-10 1994 The mean M-CSF level in MLCS of the normal fertile group was 182.0 +/- 26.1 IU/ml, in contrast, it was not detected in MLCS of recurrent aborting couples or LCS of either group. lcs 25-28 colony stimulating factor 1 Homo sapiens 9-14 34209804-10 2021 In particular, the IL-6 levels were significantly lower in the LcS group than the placebo group after the ingestion period (p < 0.05). lcs 63-66 interleukin 6 Homo sapiens 19-23 34209804-11 2021 In conclusion, the daily consumption of LcS for 9 weeks appeared to relieve constipation and improve the potentially depressive symptoms in patients with depression and significantly decrease the IL-6 levels. lcs 40-43 interleukin 6 Homo sapiens 196-200 35387438-6 2022 The amount of postoperative recombinant tissue-type plasminogen activator (rt-PA) is reduced in ART group ((57.97 +- 21.25) in LCS group vs. (40.45 +- 20.89) mg in ART group, P < 0.05), and the thrombolysis rate was higher than that of the LCS group ((74.13 +- 19.74% in LCS group) vs. (84.58 +- 11.90% in ART group %), P < 0.05). lcs 127-130 plasminogen activator, tissue type Homo sapiens 40-73 9600313-4 1998 During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level. lcs 33-36 chymase 1 Homo sapiens 114-121 9600313-4 1998 During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level. lcs 33-36 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 126-131 9600313-4 1998 During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level. lcs 33-36 Fc epsilon receptor Ia Homo sapiens 182-198 35529468-14 2022 Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha). lcs 32-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 75-97 35529468-14 2022 Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha). lcs 32-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 99-108 35529468-14 2022 Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha). lcs 32-35 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 171-183 31526758-7 2019 Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. lcs 55-58 chemokine (C-C motif) ligand 19 Mus musculus 11-16 31519201-6 2019 It also showed that the activities of total superoxide dismutase (T-SOD) and diamine oxidase (DAO) were upregulated (P < 0.05) in the LCS group. lcs 137-140 amine oxidase copper containing 1 Sus scrofa 77-92 31519201-6 2019 It also showed that the activities of total superoxide dismutase (T-SOD) and diamine oxidase (DAO) were upregulated (P < 0.05) in the LCS group. lcs 137-140 amine oxidase copper containing 1 Sus scrofa 94-97 30660616-14 2019 We conclude that after tissue injury, dorsal horn AMPARs retain a Ca2+ permeability that underlies LCS. lcs 99-102 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 50-56 30660616-14 2019 We conclude that after tissue injury, dorsal horn AMPARs retain a Ca2+ permeability that underlies LCS. lcs 99-102 carbonic anhydrase 2 Mus musculus 66-69 29687583-2 2018 We tested the hypothesis that regular LCS consumption is associated with higher postprandial glucose-dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity. lcs 38-41 gastric inhibitory polypeptide Homo sapiens 139-142 25255472-9 2015 CONCLUSIONS: Our observations suggest that spatial changes in the level and distribution of sclerostin in the alveolar LCS trigger successive bone remodelling due to orthodontic tooth movement. lcs 119-122 sclerostin Mus musculus 92-102 26971699-2 2016 In the present study, we examined the effects of IG administration of LcS on sympathetic activation induced by an intracerebroventricular (ICV) injection of corticotrophin-releasing factor (CRF) and an intravenous (IV) injection of 2-deoxy-d-glucose (2DG) or interleukin (IL)-1beta in urethane-anesthetized rats. lcs 70-73 corticotropin releasing hormone Rattus norvegicus 157-188 30061234-8 2018 RESULTS: The addition of LCS to capecitabine treatment led to an increase in the proteolysis of the FAK signaling cascade components, including SRC proto-oncogene, non-receptor tyrosine kinase; AKT serine/threonine kinase 1; and nuclear factor-kappa B, resulting in a decrease in the viability and clonogenic ability of CRC cells. lcs 25-28 protein tyrosine kinase 2 Homo sapiens 100-103 30061234-8 2018 RESULTS: The addition of LCS to capecitabine treatment led to an increase in the proteolysis of the FAK signaling cascade components, including SRC proto-oncogene, non-receptor tyrosine kinase; AKT serine/threonine kinase 1; and nuclear factor-kappa B, resulting in a decrease in the viability and clonogenic ability of CRC cells. lcs 25-28 AKT serine/threonine kinase 1 Homo sapiens 194-197 24584551-7 2014 Interestingly, dozens of proteins in OCs and/or T2D patients exhibited increased associations with IRS1 compared with LCs under the basal and/or insulin-stimulated conditions, revealing multiple new dysfunctional IRS1 pathways in OCs and T2D patients. lcs 118-121 insulin receptor substrate 1 Homo sapiens 213-217 23988911-8 2013 The CD117(+)CD11b(lo) fraction, comprising only 1-3% of total LCs, expresses higher levels of early hematopoietic progenitor markers but lower levels of mature myeloid cell markers compared to other populations of LCs. lcs 62-65 integrin alpha M Mus musculus 12-17 24772430-6 2014 PLM analysis showed the presence of lamellar LCS just to TLS. lcs 45-48 FUS RNA binding protein Homo sapiens 57-60 23988911-13 2013 We concluded that p27 represses the proliferation of LCs, which is specifically required for maintaining the quiescent and drug-resistant states of a small subset of MA9-LSCs in collaboration with the differentiation blockage function of c-Myc. lcs 53-56 cyclin-dependent kinase inhibitor 1B Mus musculus 18-21 23837662-12 2013 CONCLUSIONS: These findings support mRNA electroporation of DCs, and in particular LCs, as an effective non-viral method to stimulate specific, potent CD8+ CTL responses. lcs 83-86 CD8a molecule Homo sapiens 151-154 23894629-10 2013 The results not only provide additional evidence that LCs endocytosis occurs via the megalin/cubilin endocytic receptor system, but also show that blocking LC endocytosis by RAP can protect proximal tubule cells from LC cytotoxicity. lcs 54-57 LDL receptor related protein 2 Homo sapiens 85-92 23894629-10 2013 The results not only provide additional evidence that LCs endocytosis occurs via the megalin/cubilin endocytic receptor system, but also show that blocking LC endocytosis by RAP can protect proximal tubule cells from LC cytotoxicity. lcs 54-57 cubilin Homo sapiens 93-100 21970527-7 2012 LcS administration transiently upregulated IL-17 production by antigen-stimulated lymphocytes of draining lymph nodes 7 days after sensitization. lcs 0-3 interleukin 17A Mus musculus 43-48 22749137-2 2013 Chronic consumption of 30% fructose solution led to a significant increase in hepatic steatosis as well as plasma alanine-aminotransferase (ALT) levels, which was attenuated by treatment with Lcs. lcs 192-195 glutamic pyruvic transaminase, soluble Mus musculus 114-138 22749137-2 2013 Chronic consumption of 30% fructose solution led to a significant increase in hepatic steatosis as well as plasma alanine-aminotransferase (ALT) levels, which was attenuated by treatment with Lcs. lcs 192-195 glutamic pyruvic transaminase, soluble Mus musculus 140-143 21477953-7 2011 When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required. lcs 5-8 mechanistic target of rapamycin kinase Bos taurus 65-69 21477953-7 2011 When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required. lcs 5-8 hypoxia inducible factor 1 subunit alpha Bos taurus 104-114 21477953-7 2011 When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required. lcs 5-8 vascular endothelial growth factor A Bos taurus 119-123 21477953-7 2011 When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required. lcs 5-8 chorionic gonadotropin subunit beta 5 Homo sapiens 146-149 19235606-5 2009 Pre-incubation with p-cresol inhibited IL-12 p40 production of LcS-stimulated J774.1 cells, a murine macrophage-like cell line, in a dose-dependent manner. lcs 63-66 interleukin 12b Mus musculus 39-48 19589943-7 2009 Both L-lactic acid and LcS culture supernatant containing 10 mM lactic acid inhibited NF-kappaB activation and increases in TNF-alpha mRNA expression and TNF-alpha protein secretion in THP-1 cells treated with LPS. lcs 23-26 tumor necrosis factor Homo sapiens 124-133 19589943-7 2009 Both L-lactic acid and LcS culture supernatant containing 10 mM lactic acid inhibited NF-kappaB activation and increases in TNF-alpha mRNA expression and TNF-alpha protein secretion in THP-1 cells treated with LPS. lcs 23-26 tumor necrosis factor Homo sapiens 154-163 19740306-11 2009 In the IBD model, ingestion of LcS improved ileitis and inhibited activation of IL-6/STAT3 signaling, while ingestion of the LC(DeltaPSPG-I) strain did not. lcs 31-34 interleukin 6 Mus musculus 80-84 19740306-11 2009 In the IBD model, ingestion of LcS improved ileitis and inhibited activation of IL-6/STAT3 signaling, while ingestion of the LC(DeltaPSPG-I) strain did not. lcs 31-34 signal transducer and activator of transcription 3 Mus musculus 85-90 19740306-12 2009 In the CAC model, treatment with LcS, but not the LC(DeltaPSPG-I) strain, showed tumour-suppressive effects with an inhibition of IL-6 production in the colonic mucosa. lcs 33-36 interleukin 6 Mus musculus 130-134 19235606-6 2009 IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol. lcs 32-35 interleukin 12b Mus musculus 0-9 19235606-6 2009 IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol. lcs 32-35 interleukin 2 receptor, beta chain Mus musculus 14-17 15961107-6 2005 Our results indicated that LcS may be a safe and beneficial agent for the treatment of HAM/TSP; therefore randomized controlled studies are warranted. lcs 27-30 thrombospondin 1 Homo sapiens 91-94 16875751-8 2006 These varying effects on Th1 responses indicate that beneficial as well as harmful effects on immune related disorders could occur after LcS consumption. lcs 137-140 negative elongation factor complex member C/D, Th1l Mus musculus 25-28 11972603-8 2002 In the food allergy model, LcS administration skewed the pattern of cytokine production by splenocytes toward Th1 dominance, and suppressed IgE and IgG1 secretion by splenocytes. lcs 27-30 negative elongation factor complex member C/D, Th1l Mus musculus 110-113 15932502-4 2005 We focused the inhibitory effect of LcS on the production of IL-6 in lipopolysaccharide (LPS)-stimulated large intestinal lamina propria mononuclear cells (LI-LPMC) isolated from mice with chronic colitis and in RAW264.7 cells in vitro. lcs 36-39 interleukin 6 Mus musculus 61-65 15932502-9 2005 LcS also improved chronic ileitis in SAMP1/Yit mice. lcs 0-3 transmembrane protein 201 Mus musculus 37-42 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 interleukin 6 Homo sapiens 69-73 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 C-C motif chemokine ligand 2 Homo sapiens 84-118 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 C-C motif chemokine ligand 2 Homo sapiens 120-125 15895514-10 2004 The hierarchical clustering of the TGGE profiles indicated that the cecal microflora of pig A resembled that of pig C and that of pig B was dissimilar to those of pigs A and C. These results indicated that the effect of LCS on fermentation in the large intestine was possibly dependent on the composition of indigenous microflora. lcs 220-223 phosphatidylinositol glycan anchor biosynthesis class B Sus scrofa 130-135 15082127-4 2004 Two minutes after running on the treadmill apparatus, phosphorylation of ERK was induced in neurons in the superficial laminae in the LCS group but not in the sham group, whereas there was no change in the deeper laminae. lcs 134-137 Eph receptor B1 Rattus norvegicus 73-76 11972603-8 2002 In the food allergy model, LcS administration skewed the pattern of cytokine production by splenocytes toward Th1 dominance, and suppressed IgE and IgG1 secretion by splenocytes. lcs 27-30 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 148-152 11972603-11 2002 CONCLUSION: LcS administration suppresses IgE and IgG1 responses and systemic allergic reactions in a food allergy model, suggesting a possible use of this lactic acid bacterium in preventing food allergy. lcs 12-15 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 50-54