PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30660616-14	2019	We conclude that after tissue injury, dorsal horn AMPARs retain a Ca2+ permeability that underlies LCS.	lcs	99-102	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	50-56
31526758-7	2019	Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation.	lcs	55-58	chemokine (C-C motif) ligand 19	Mus musculus	11-16
31519201-6	2019	It also showed that the activities of total superoxide dismutase (T-SOD) and diamine oxidase (DAO) were upregulated (P < 0.05) in the LCS group.	lcs	137-140	amine oxidase copper containing 1	Sus scrofa	77-92
31519201-6	2019	It also showed that the activities of total superoxide dismutase (T-SOD) and diamine oxidase (DAO) were upregulated (P < 0.05) in the LCS group.	lcs	137-140	amine oxidase copper containing 1	Sus scrofa	94-97
30660616-14	2019	We conclude that after tissue injury, dorsal horn AMPARs retain a Ca2+ permeability that underlies LCS.	lcs	99-102	carbonic anhydrase 2	Mus musculus	66-69
29687583-2	2018	We tested the hypothesis that regular LCS consumption is associated with higher postprandial glucose-dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity.	lcs	38-41	gastric inhibitory polypeptide	Homo sapiens	93-137
29687583-2	2018	We tested the hypothesis that regular LCS consumption is associated with higher postprandial glucose-dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity.	lcs	38-41	gastric inhibitory polypeptide	Homo sapiens	139-142
30061234-8	2018	RESULTS: The addition of LCS to capecitabine treatment led to an increase in the proteolysis of the FAK signaling cascade components, including SRC proto-oncogene, non-receptor tyrosine kinase; AKT serine/threonine kinase 1; and nuclear factor-kappa B, resulting in a decrease in the viability and clonogenic ability of CRC cells.	lcs	25-28	protein tyrosine kinase 2	Homo sapiens	100-103
30061234-8	2018	RESULTS: The addition of LCS to capecitabine treatment led to an increase in the proteolysis of the FAK signaling cascade components, including SRC proto-oncogene, non-receptor tyrosine kinase; AKT serine/threonine kinase 1; and nuclear factor-kappa B, resulting in a decrease in the viability and clonogenic ability of CRC cells.	lcs	25-28	AKT serine/threonine kinase 1	Homo sapiens	194-197
24584551-7	2014	Interestingly, dozens of proteins in OCs and/or T2D patients exhibited increased associations with IRS1 compared with LCs under the basal and/or insulin-stimulated conditions, revealing multiple new dysfunctional IRS1 pathways in OCs and T2D patients.	lcs	118-121	insulin receptor substrate 1	Homo sapiens	213-217
26971699-2	2016	In the present study, we examined the effects of IG administration of LcS on sympathetic activation induced by an intracerebroventricular (ICV) injection of corticotrophin-releasing factor (CRF) and an intravenous (IV) injection of 2-deoxy-d-glucose (2DG) or interleukin (IL)-1beta in urethane-anesthetized rats.	lcs	70-73	corticotropin releasing hormone	Rattus norvegicus	157-188
25255472-9	2015	CONCLUSIONS: Our observations suggest that spatial changes in the level and distribution of sclerostin in the alveolar LCS trigger successive bone remodelling due to orthodontic tooth movement.	lcs	119-122	sclerostin	Mus musculus	92-102
23894629-10	2013	The results not only provide additional evidence that LCs endocytosis occurs via the megalin/cubilin endocytic receptor system, but also show that blocking LC endocytosis by RAP can protect proximal tubule cells from LC cytotoxicity.	lcs	54-57	LDL receptor related protein 2	Homo sapiens	85-92
24772430-6	2014	PLM analysis showed the presence of lamellar LCS just to TLS.	lcs	45-48	FUS RNA binding protein	Homo sapiens	57-60
23988911-8	2013	The CD117(+)CD11b(lo) fraction, comprising only 1-3% of total LCs, expresses higher levels of early hematopoietic progenitor markers but lower levels of mature myeloid cell markers compared to other populations of LCs.	lcs	62-65	integrin alpha M	Mus musculus	12-17
23988911-13	2013	We concluded that p27 represses the proliferation of LCs, which is specifically required for maintaining the quiescent and drug-resistant states of a small subset of MA9-LSCs in collaboration with the differentiation blockage function of c-Myc.	lcs	53-56	cyclin-dependent kinase inhibitor 1B	Mus musculus	18-21
23894629-10	2013	The results not only provide additional evidence that LCs endocytosis occurs via the megalin/cubilin endocytic receptor system, but also show that blocking LC endocytosis by RAP can protect proximal tubule cells from LC cytotoxicity.	lcs	54-57	cubilin	Homo sapiens	93-100
22749137-2	2013	Chronic consumption of 30% fructose solution led to a significant increase in hepatic steatosis as well as plasma alanine-aminotransferase (ALT) levels, which was attenuated by treatment with Lcs.	lcs	192-195	glutamic pyruvic transaminase, soluble	Mus musculus	114-138
23837662-12	2013	CONCLUSIONS: These findings support mRNA electroporation of DCs, and in particular LCs, as an effective non-viral method to stimulate specific, potent CD8+ CTL responses.	lcs	83-86	CD8a molecule	Homo sapiens	151-154
22749137-2	2013	Chronic consumption of 30% fructose solution led to a significant increase in hepatic steatosis as well as plasma alanine-aminotransferase (ALT) levels, which was attenuated by treatment with Lcs.	lcs	192-195	glutamic pyruvic transaminase, soluble	Mus musculus	140-143
21970527-7	2012	LcS administration transiently upregulated IL-17 production by antigen-stimulated lymphocytes of draining lymph nodes 7 days after sensitization.	lcs	0-3	interleukin 17A	Mus musculus	43-48
19235606-5	2009	Pre-incubation with p-cresol inhibited IL-12 p40 production of LcS-stimulated J774.1 cells, a murine macrophage-like cell line, in a dose-dependent manner.	lcs	63-66	interleukin 12b	Mus musculus	39-48
19589943-7	2009	Both L-lactic acid and LcS culture supernatant containing 10 mM lactic acid inhibited NF-kappaB activation and increases in TNF-alpha mRNA expression and TNF-alpha protein secretion in THP-1 cells treated with LPS.	lcs	23-26	tumor necrosis factor	Homo sapiens	124-133
19589943-7	2009	Both L-lactic acid and LcS culture supernatant containing 10 mM lactic acid inhibited NF-kappaB activation and increases in TNF-alpha mRNA expression and TNF-alpha protein secretion in THP-1 cells treated with LPS.	lcs	23-26	tumor necrosis factor	Homo sapiens	154-163
21477953-7	2011	When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required.	lcs	5-8	mechanistic target of rapamycin kinase	Bos taurus	65-69
21477953-7	2011	When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required.	lcs	5-8	hypoxia inducible factor 1 subunit alpha	Bos taurus	104-114
21477953-7	2011	When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required.	lcs	5-8	vascular endothelial growth factor A	Bos taurus	119-123
21477953-7	2011	When LCs were pretreated with inhibitors, we found that the PI3K/mTOR signaling pathway is required for HIF-1alpha and VEGF expression induced by hCG, while the MAPK pathway is not required.	lcs	5-8	chorionic gonadotropin subunit beta 5	Homo sapiens	146-149
19740306-11	2009	In the IBD model, ingestion of LcS improved ileitis and inhibited activation of IL-6/STAT3 signaling, while ingestion of the LC(DeltaPSPG-I) strain did not.	lcs	31-34	interleukin 6	Mus musculus	80-84
19740306-11	2009	In the IBD model, ingestion of LcS improved ileitis and inhibited activation of IL-6/STAT3 signaling, while ingestion of the LC(DeltaPSPG-I) strain did not.	lcs	31-34	signal transducer and activator of transcription 3	Mus musculus	85-90
19740306-12	2009	In the CAC model, treatment with LcS, but not the LC(DeltaPSPG-I) strain, showed tumour-suppressive effects with an inhibition of IL-6 production in the colonic mucosa.	lcs	33-36	interleukin 6	Mus musculus	130-134
19235606-6	2009	IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol.	lcs	32-35	interleukin 12b	Mus musculus	0-9
19235606-6	2009	IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol.	lcs	32-35	interleukin 2 receptor, beta chain	Mus musculus	14-17
16875751-8	2006	These varying effects on Th1 responses indicate that beneficial as well as harmful effects on immune related disorders could occur after LcS consumption.	lcs	137-140	negative elongation factor complex member C/D, Th1l	Mus musculus	25-28
15961107-6	2005	Our results indicated that LcS may be a safe and beneficial agent for the treatment of HAM/TSP; therefore randomized controlled studies are warranted.	lcs	27-30	thrombospondin 1	Homo sapiens	91-94
15082127-4	2004	Two minutes after running on the treadmill apparatus, phosphorylation of ERK was induced in neurons in the superficial laminae in the LCS group but not in the sham group, whereas there was no change in the deeper laminae.	lcs	134-137	Eph receptor B1	Rattus norvegicus	73-76
15895514-10	2004	The hierarchical clustering of the TGGE profiles indicated that the cecal microflora of pig A resembled that of pig C and that of pig B was dissimilar to those of pigs A and C. These results indicated that the effect of LCS on fermentation in the large intestine was possibly dependent on the composition of indigenous microflora.	lcs	220-223	phosphatidylinositol glycan anchor biosynthesis class B	Sus scrofa	130-135
15932502-4	2005	We focused the inhibitory effect of LcS on the production of IL-6 in lipopolysaccharide (LPS)-stimulated large intestinal lamina propria mononuclear cells (LI-LPMC) isolated from mice with chronic colitis and in RAW264.7 cells in vitro.	lcs	36-39	interleukin 6	Mus musculus	61-65
15932502-9	2005	LcS also improved chronic ileitis in SAMP1/Yit mice.	lcs	0-3	transmembrane protein 201	Mus musculus	37-42
12427122-6	2002	RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs.	lcs	24-27	interleukin 6	Homo sapiens	69-73
12427122-6	2002	RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs.	lcs	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12427122-6	2002	RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs.	lcs	24-27	C-C motif chemokine ligand 2	Homo sapiens	84-118
12427122-6	2002	RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs.	lcs	24-27	C-C motif chemokine ligand 2	Homo sapiens	120-125
9704862-5	1998	administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival.	lcs	18-21	interferon gamma	Mus musculus	92-101
11972603-8	2002	In the food allergy model, LcS administration skewed the pattern of cytokine production by splenocytes toward Th1 dominance, and suppressed IgE and IgG1 secretion by splenocytes.	lcs	27-30	negative elongation factor complex member C/D, Th1l	Mus musculus	110-113
11972603-8	2002	In the food allergy model, LcS administration skewed the pattern of cytokine production by splenocytes toward Th1 dominance, and suppressed IgE and IgG1 secretion by splenocytes.	lcs	27-30	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	148-152
11972603-11	2002	CONCLUSION: LcS administration suppresses IgE and IgG1 responses and systemic allergic reactions in a food allergy model, suggesting a possible use of this lactic acid bacterium in preventing food allergy.	lcs	12-15	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	50-54
10230875-2	1999	In this study, we examined whether LcS can induce the production of interleukin (IL)-12 and interferon-gamma (IFN-gamma), which are important cytokines for antitumor and antimicrobial immunity, from murine splenocytes in vitro in order to clarify the mechanisms of its immune modification.	lcs	35-38	interferon gamma	Mus musculus	92-108
10230875-2	1999	In this study, we examined whether LcS can induce the production of interleukin (IL)-12 and interferon-gamma (IFN-gamma), which are important cytokines for antitumor and antimicrobial immunity, from murine splenocytes in vitro in order to clarify the mechanisms of its immune modification.	lcs	35-38	interferon gamma	Mus musculus	110-119
10230875-3	1999	Stimulation by LcS induced a marked production of IL-12 by X-ray-irradiated splenocytes (X-irr-Spl).	lcs	15-18	plasma serotonin level	Mus musculus	95-98
10230875-6	1999	LcS showed a synergistic stimulatory effect on the ConA-induced production of IFN-gamma.	lcs	0-3	interferon gamma	Mus musculus	78-87
10230875-11	1999	Furthermore, in BALB/c mice, the oral administration of viable LcS augmented the production of IFN-gamma but not that of IL-4 or IL-5 by splenocytes.	lcs	63-66	interferon gamma	Mus musculus	95-104
9704862-5	1998	administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival.	lcs	18-21	interleukin 1 beta	Mus musculus	103-111
9704862-5	1998	administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival.	lcs	18-21	tumor necrosis factor	Mus musculus	116-125
34209804-10	2021	In particular, the IL-6 levels were significantly lower in the LcS group than the placebo group after the ingestion period (p < 0.05).	lcs	63-66	interleukin 6	Homo sapiens	19-23
8040620-10	1994	The mean M-CSF level in MLCS of the normal fertile group was 182.0 +/- 26.1 IU/ml, in contrast, it was not detected in MLCS of recurrent aborting couples or LCS of either group.	lcs	25-28	colony stimulating factor 1	Homo sapiens	9-14
9600313-4	1998	During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level.	lcs	33-36	chymase 1	Homo sapiens	114-121
9600313-4	1998	During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level.	lcs	33-36	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	126-131
9600313-4	1998	During a 10 day culture with 30% LCS, a significant, time-dependent increase of all mast cell markers, except for chymase and c-Kit, was observed at the protein and for tryptase and FcepsilonRIalpha also at the mRNA level.	lcs	33-36	Fc epsilon receptor Ia	Homo sapiens	182-198
34209804-11	2021	In conclusion, the daily consumption of LcS for 9 weeks appeared to relieve constipation and improve the potentially depressive symptoms in patients with depression and significantly decrease the IL-6 levels.	lcs	40-43	interleukin 6	Homo sapiens	196-200
35387438-6	2022	The amount of postoperative recombinant tissue-type plasminogen activator (rt-PA) is reduced in ART group ((57.97 +- 21.25) in LCS group vs. (40.45 +- 20.89) mg in ART group, P < 0.05), and the thrombolysis rate was higher than that of the LCS group ((74.13 +- 19.74% in LCS group) vs. (84.58 +- 11.90% in ART group %), P < 0.05).	lcs	127-130	plasminogen activator, tissue type	Homo sapiens	40-73
35529468-14	2022	Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha).	lcs	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-97
35529468-14	2022	Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha).	lcs	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
35529468-14	2022	Mechanistically, we showed that LcS treatment suppressed the activation of nuclear factor-kappa B (NF-kappaB) signaling via stabilization of inhibitor of NF-kappaB alpha (IkappaBalpha).	lcs	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	171-183