PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8573115-0	1996	Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.	Iproniazid	52-62	monoamine oxidase B	Homo sapiens	118-137
21200377-7	2010	MAO-A was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > desipramine > amitriptyline > imipramine > citalopram > venlafaxine > reboxetine > olanzapine > mirtazapine > tianeptine > moclobemide, cocaine >> lithium, valproate.	Iproniazid	75-85	monoamine oxidase A	Sus scrofa	0-5
21200377-8	2010	MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > venlafaxine > amitriptyline > olanzapine > citalopram > desipramine > reboxetine > imipramine > tianeptine > mirtazapine, cocaine >> moclobemide, lithium, valproate.	Iproniazid	75-85	monoamine oxidase B	Sus scrofa	0-5
19105176-4	2009	This conversion could be significantly inhibited with the monamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) inhibitor iproniazid.	Iproniazid	140-150	amine oxidase, copper containing 3	Rattus norvegicus	85-122
19105176-4	2009	This conversion could be significantly inhibited with the monamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) inhibitor iproniazid.	Iproniazid	140-150	amine oxidase, copper containing 3	Rattus norvegicus	124-128
17928708-3	2007	The activity of rose petal AADC to yield phenylacetaldehyde was nine times higher toward L-phenylalanine than toward its D-isomer, and this conversion was not inhibited by iproniazid, a specific inhibitor of monoamine oxidase.	Iproniazid	172-182	dopa decarboxylase	Homo sapiens	27-31
16002749-6	2005	Treatment with SB224289 (selective antagonist of 5-HT1B), fluoxetine (SERT inhibitor), SERT RNA-interference, and iproniazid (monoamine oxidase-A inhibitor), blocked 5-HT-induced S100A4/Mts1.	Iproniazid	114-124	monoamine oxidase A	Homo sapiens	126-145
10799660-5	2000	These potencies were similar to those of the antidepressant MAO inhibitors iproniazid and moclobemide.	Iproniazid	75-85	monoamine oxidase A	Rattus norvegicus	60-63
9409087-6	1997	Importantly, iproniazid, the nonselective MAO inhibitor, caused changes in PBR binding in all three of the tissues.	Iproniazid	13-23	resistance to Paracoccidioides brasiliensis	Mus musculus	75-78
7901387-1	1993	Time- and dose-response analyses were undertaken to investigate the effects of the substituted hydrazine monoamine oxidase (MAO) inhibitors iproniazid and nialamide on the following: MAO-A and -B activity; levels of gamma-aminobutyric acid (GABA), alanine (ALA), and the neurotransmitter amines dopamine, noradrenaline, and 5-hydroxytryptamine (serotonin) and their acid metabolites; and the activity of GABA-transaminase and ALA-transaminase.	Iproniazid	140-150	monoamine oxidase A	Rattus norvegicus	124-127
3664088-8	1987	In vitro treatment with the monoamine oxidase (MAO) inhibitors, iproniazid or pargyline, did not potentiate responses to either noradrenaline or isoprenaline.	Iproniazid	64-74	monoamine oxidase A	Rattus norvegicus	28-45
1850332-3	1991	5HT (1 microM) plus 0.1 mM iproniazid (a 5HT metabolic inhibitor) produced a severalfold stimulation of DNA synthesis (as measured by [3H]thymidine incorporation) of SMCs after a 17-24-hour incubation with only a slight elevation of cellular cAMP.	Iproniazid	27-37	cathelicidin-7	Bos taurus	242-246
1667771-0	1991	Cytochrome P-450- and peroxidase-dependent activation of procarbazine and iproniazid in mammalian cells.	Iproniazid	74-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-32
1667771-5	1991	However, in HL60 cells, procarbazine was metabolized by myeloperoxidase while iproniazid was metabolized mostly by the cytochrome P-450 system.	Iproniazid	78-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-135
3664088-8	1987	In vitro treatment with the monoamine oxidase (MAO) inhibitors, iproniazid or pargyline, did not potentiate responses to either noradrenaline or isoprenaline.	Iproniazid	64-74	monoamine oxidase A	Rattus norvegicus	47-50
6146119-5	1984	Iproniazid potentiated the TRH effects, in normal Ringer"s solution.	Iproniazid	0-10	thyrotropin releasing hormone	Homo sapiens	27-30
3974403-5	1985	Iproniazid must be directly metabolized by cytochrome P-450 to yield propane and propylene, presumably via an azo ester intermediate which could give rise to an isopropyl radical, the chemical species presumed to be responsible for the hepatoxicity apparent after administration of large doses of iproniazid in vivo.	Iproniazid	0-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
3974403-5	1985	Iproniazid must be directly metabolized by cytochrome P-450 to yield propane and propylene, presumably via an azo ester intermediate which could give rise to an isopropyl radical, the chemical species presumed to be responsible for the hepatoxicity apparent after administration of large doses of iproniazid in vivo.	Iproniazid	297-307	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
6506753-4	1984	The 1,2-disubstituted hydrazines and hydrazides, procarbazine and iproniazid, acted similarly to the monosubstituted hydrazines, while 1,2-dimethylhydrazine elicited no response, either in observable spectral changes or loss of CO-reactive cytochrome P-450.	Iproniazid	66-76	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	240-256
7257826-4	1981	The uptake was moderately potentiated by the MAO inhibitor iproniazid (3 micrometers) after 30-60 min.	Iproniazid	59-69	monoamine oxidase A	Rattus norvegicus	45-48
6772465-1	1980	In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine.	Iproniazid	106-116	monoamine oxidase A	Rattus norvegicus	74-91
6772465-1	1980	In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine.	Iproniazid	106-116	monoamine oxidase A	Rattus norvegicus	93-96
6448425-0	1980	Influence of D-penicillamine and iproniazid on the formation of cross-links in elastin.	Iproniazid	33-43	elastin	Homo sapiens	79-86
7456355-3	1980	The MAO activating effect of N-methyl octahydronaphthazepines in the brain homogenates occurred when the enzymatic activity was previously inhibited with iproniazid.	Iproniazid	154-164	monoamine oxidase A	Rattus norvegicus	4-7
317700-1	1979	The acute administration of the monoamine oxidase inhibitor iproniazid to rats causes a highly significant suppression of serum prolactin levels at 2 h. At the same time there is a significant rise in the hypothalamic-median eminence concentrations of the biogenic monoamines dopamine, noradrenaline and serotonin.	Iproniazid	60-70	prolactin	Rattus norvegicus	128-137
317700-2	1979	When iproniazid is administered daily to rats for 4 days and the animals are examined on the fifth day brain noradrenaline and serotonin levels are elevated similarly to those seen after acute administration but dopamine concentration is near normal while serum prolactin is significantly elevated.	Iproniazid	5-15	prolactin	Rattus norvegicus	262-271
317700-3	1979	This study thus demonstrates that a quite specific and unexpected change occurs in the regulation of hypothalamic-median eminence dopamine when iproniazid is administered chronically and provides an explanation of previous observations in human subjects where raised serum prolactin levels are observed after chronic therapy with monoamine oxidase inhibitors.	Iproniazid	144-154	prolactin	Homo sapiens	273-282
44325-3	1979	alpha-blockers (phenoxybenzamine and phentolamine) and monoamine oxidase (MAO) inhibitor (iproniazide) produced an increased accumulation of 5-HT fluorescence in the apical regions of acinar cells where the zymogen granules are stored.	Iproniazid	90-101	monoamine oxidase A	Rattus norvegicus	55-72
44325-3	1979	alpha-blockers (phenoxybenzamine and phentolamine) and monoamine oxidase (MAO) inhibitor (iproniazide) produced an increased accumulation of 5-HT fluorescence in the apical regions of acinar cells where the zymogen granules are stored.	Iproniazid	90-101	monoamine oxidase A	Rattus norvegicus	74-77
108709-1	1979	Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats.	Iproniazid	37-47	monoamine oxidase A	Rattus norvegicus	22-25
837973-8	1977	The data indicate that chronic glucocorticoid treatment may have a slight inhibitory effect on brain MAO and also has the ability to partially reverse or antagonize the inhibition of MAO caused by iproniazid.	Iproniazid	197-207	monoamine oxidase A	Rattus norvegicus	183-186
499103-1	1979	Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide.	Iproniazid	163-174	monoamine oxidase A	Rattus norvegicus	31-34
837973-2	1977	Opposite results with dexamethasone were obtained in iproniazid (MAO-inhibited)-treated rats.	Iproniazid	53-63	monoamine oxidase A	Rattus norvegicus	65-68
16955968-3	1965	The MAO-inhibitors phenylcyclopropylamino hydrochloride and nialamide show enhancement of activity in most combinations whereas iproniazid never does.	Iproniazid	128-138	monoamine oxidase A	Rattus norvegicus	4-7
12389-8	1976	The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates.	Iproniazid	71-81	monoamine oxidase A	Rattus norvegicus	32-35
4295-3	1975	We recently demonstrated that pancreatic islets contain substantial amounts of monoamine oxidase (MAO), and that MAO inhibitors such as iproniazid and tranylcypromine can alter insulin secretion.	Iproniazid	136-146	insulin	Oryctolagus cuniculus	177-184
1143390-0	1975	Proceedings: Age dependent recovery of rat brain MAO activity after administration of a single dose of iproniazid and pargyline.	Iproniazid	103-113	monoamine oxidase A	Rattus norvegicus	49-52
5530995-0	1970	Inhibition of elastin cross-linking by iproniazid and its counteraction by pyridoxal phosphate.	Iproniazid	39-49	elastin	Homo sapiens	14-21
13614210-0	1958	[Iproniazid & prothrombin concentration].	Iproniazid	1-11	coagulation factor II, thrombin	Homo sapiens	18-29
14256808-5	1964	Iproniazid and aminoguanidine potentiated responses to gastrin.	Iproniazid	0-10	gastrin	Rattus norvegicus	55-62
33640631-4	2021	Among them, compound 4d was the most potent hMAO-B inhibitor (IC50 = 0.37 nM) being about 20783-fold more active than iproniazid, and exhibited the highest selectivity for hMAO-B (SI > 270,270).	Iproniazid	118-128	monoamine oxidase B	Homo sapiens	44-50
26404523-3	2016	We report a clinical observation of pseudo-pheochromocytoma due to iproniazid, a non-selective irreversible monoamine oxidase (MAO) A and B inhibitor in a patient with bipolar disorder.	Iproniazid	67-77	monoamine oxidase A	Homo sapiens	108-139
22137786-5	2012	Moreover, the presence of a chloro atom in the six position of the moiety (compound 7) improved the inhibitor activity as well as its selectivity against MAO-B compared with iproniazide, used as reference compound.	Iproniazid	174-185	monoamine oxidase B	Homo sapiens	154-159