PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31278966-0	2019	In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: Prediction of pesticide-drug interactions.	fipronil sulfone	88-104	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	29-35
35500697-0	2022	Fipronil and fipronil sulfone in chicken: From in vitro experiments to in vivo PBK model predictions.	fipronil sulfone	13-29	PDZ binding kinase	Gallus gallus	79-82
31278966-10	2019	On the other hand, the metabolite fipronil sulfone showed to be a strong inhibitor of CYP2D6 also by competitive inhibition.	fipronil sulfone	34-50	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	86-92
31278966-11	2019	These results highlight the importance of metabolite evaluation on pesticide safety since the metabolism of fipronil into fipronil sulfone increases the risk of pesticide-drug interactions for drugs metabolized by CYP2D6.	fipronil sulfone	122-138	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	214-220
30521755-3	2019	The limits of detection of fipronil and fipronil-sulfone in the rodent sera by the corresponding ELISAs were 10 and 30 ng mL-1, and the linear ranges were 30-1000 and 75-2200 ng mL-1.	fipronil sulfone	40-56	L1 cell adhesion molecule	Mus musculus	122-126
30521755-6	2019	The average concentration of fipronil-sulfone was approximately 3.2-fold higher than fipronil in the prairie dog sera (1.15 vs 0.36 mug mL-1) and rat sera (1.77 vs 0.53 mug mL-1).	fipronil sulfone	29-45	L1 cell adhesion molecule	Mus musculus	136-140
30521755-6	2019	The average concentration of fipronil-sulfone was approximately 3.2-fold higher than fipronil in the prairie dog sera (1.15 vs 0.36 mug mL-1) and rat sera (1.77 vs 0.53 mug mL-1).	fipronil sulfone	29-45	L1 cell adhesion molecule	Mus musculus	173-177
26142839-8	2015	Further investigations are required to in vivo evaluate the potential of the metabolite fipronil sulfone as an inducer of phase I CYP enzymes.	fipronil sulfone	88-104	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	130-133
22447239-4	2012	We postulated that fipronil biotransformation into fipronil sulfone by hepatic cytochromes P450 (CYP) could act as a potential thyroid disruptor.	fipronil sulfone	51-67	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	79-95
25112704-5	2015	For estrogenic and antiestrogenic activities, both fipronil and fipronil sulfone showed no agonistic activities but exhibited the similarly antagonistic activities via estrogen receptor alpha (ERalpha), with the RIC20 of 6.4 x 10(-7)M and 9.8 x 10(-7)M, respectively.	fipronil sulfone	64-80	estrogen receptor	Cricetulus griseus	168-191
22447239-4	2012	We postulated that fipronil biotransformation into fipronil sulfone by hepatic cytochromes P450 (CYP) could act as a potential thyroid disruptor.	fipronil sulfone	51-67	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	97-100
22447239-5	2012	The aim of this study was to determine if fipronil sulfone treatment could reproduce the fipronil treatment effects on T(4) clearance and CYP induction in rats.	fipronil sulfone	42-58	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	138-141