PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31302315-2	2019	Molecular docking revealed that jatrorrhizine, a protoberberine alkaloid, exhibits good binding affinity and interaction with TNIK.	protoberberine alkaloid	49-72	TRAF2 and NCK interacting kinase	Homo sapiens	126-130
30171419-3	2018	In this study, we identified protoberberine alkaloid pseudodehydrocorydaline (CT13) as a novel G9a inhibitor, by structure-based virtual screening of in-house library containing natural product compounds.	protoberberine alkaloid	29-52	MAGE family member A3	Homo sapiens	78-82
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	ATR serine/threonine kinase	Homo sapiens	93-96
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	mitogen-activated protein kinase 14	Homo sapiens	97-100
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	Janus kinase 2	Homo sapiens	114-118
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	signal transducer and activator of transcription 1	Homo sapiens	119-124
29486184-0	2018	Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways.	protoberberine alkaloid	12-35	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
11901227-0	2002	Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine.	protoberberine alkaloid	96-119	ATPase, class II, type 9A	Mus musculus	37-44
19576980-4	2009	The protoberberine alkaloid contents of MOR(EtOH) were identified by high-performance liquid chromatography (HPLC).	protoberberine alkaloid	4-27	opioid receptor, mu 1	Mus musculus	40-43