PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23376036-5	2013	Epac was selectively activated by 8-CPT-AM (acetoxymethyl ester form of 8-CPT).	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	34-42	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	0-4
30873562-6	2019	This small molecule prevents the activation of the Epac1 downstream effector Rap1 in cultured cells, in response to the Epac1 preferential agonist, 8-CPT-AM.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	148-156	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	51-56
30873562-6	2019	This small molecule prevents the activation of the Epac1 downstream effector Rap1 in cultured cells, in response to the Epac1 preferential agonist, 8-CPT-AM.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	148-156	RAS-related protein 1a	Mus musculus	77-81
30873562-6	2019	This small molecule prevents the activation of the Epac1 downstream effector Rap1 in cultured cells, in response to the Epac1 preferential agonist, 8-CPT-AM.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	148-156	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	120-125
23959673-3	2013	In myography experiments, the Epac-selective cAMP analogue 8-pCPT-2-O-Me-cAMP-AM (5 muM, subsequently referred to as 8-pCPT-AM) elicited a 77.6 +- 7.1% relaxation of phenylephrine-contracted arteries over a 5 min period (mean +- SEM; n = 6).	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	59-80	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	30-34
21791615-8	2011	Using RNA interference (RNAi), we further demonstrate that 8-(4-chlorophenylthio)-2"-O-Me-cAMP-AM (8-CPT-AM), an Epac activator, stimulates syncytin-1 and -2 gene expression and cell fusion of placental BeWo cells in a GCM1-dependent manner.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	99-107	Rap guanine nucleotide exchange factor 3	Homo sapiens	113-117
21791615-8	2011	Using RNA interference (RNAi), we further demonstrate that 8-(4-chlorophenylthio)-2"-O-Me-cAMP-AM (8-CPT-AM), an Epac activator, stimulates syncytin-1 and -2 gene expression and cell fusion of placental BeWo cells in a GCM1-dependent manner.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	99-107	endogenous retrovirus group W member 1, envelope	Homo sapiens	140-157
21791615-8	2011	Using RNA interference (RNAi), we further demonstrate that 8-(4-chlorophenylthio)-2"-O-Me-cAMP-AM (8-CPT-AM), an Epac activator, stimulates syncytin-1 and -2 gene expression and cell fusion of placental BeWo cells in a GCM1-dependent manner.	8-(4-chlorophenylthio)-2'-O-methyl-cAMP acetoxymethyl ester	99-107	glial cells missing transcription factor 1	Homo sapiens	219-223