PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21464033-0	2011	Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.	indenoisoquinolines	89-108	retinoid X receptor alpha	Homo sapiens	13-32
31283877-6	2019	Here, we report that anticancer indenoisoquinolines strongly bind and stabilize MycG4 and lower MYC expression levels in cancer cells, using various biochemical, biophysical, computer modeling, and cell-based methods.	indenoisoquinolines	32-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	96-99
31283877-7	2019	Significantly, a large number of active indenoisoquinolines cause strong MYC downregulation in cancer cells.	indenoisoquinolines	40-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-76
31283877-10	2019	Therefore, this study uncovers a novel mechanism of action of indenoisoquinolines as a new family of drugs targeting the MYC promoter G-quadruplex for MYC suppression.	indenoisoquinolines	62-81	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	121-124
31283877-10	2019	Therefore, this study uncovers a novel mechanism of action of indenoisoquinolines as a new family of drugs targeting the MYC promoter G-quadruplex for MYC suppression.	indenoisoquinolines	62-81	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	151-154
24800942-3	2014	This study describes the successful design and synthesis of 2-position-modified indenoisoquinolines as dual Top1-TDP1 inhibitors using a structure-based drug design approach.	indenoisoquinolines	80-99	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	113-117
24800942-4	2014	Enzyme inhibition studies indicate that indenoisoquinolines modified at the 2-position with three-carbon side chains ending with amino substituents show both promising Top1 and TDP1 inhibitory activity.	indenoisoquinolines	40-59	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	177-181
23472886-4	2013	This communication presents the design, synthesis, and biological evaluation of both acidic and nonacidic indenoisoquinolines as new RXR ligands.	indenoisoquinolines	106-125	retinoid X receptor alpha	Homo sapiens	133-136
23259865-0	2013	Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).	indenoisoquinolines	39-58	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	110-114
23259865-2	2013	This report documents the design, synthesis, and evaluation of new indenoisoquinolines that are dual inhibitors of both Tdp1 and Top1.	indenoisoquinolines	67-86	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	120-124
23259865-4	2013	The potencies of the indenoisoquinolines against Tdp1 ranged from 5 muM to 111 muM, which places the more active compounds among the most potent known inhibitors of this target.	indenoisoquinolines	21-40	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	49-53
23259865-4	2013	The potencies of the indenoisoquinolines against Tdp1 ranged from 5 muM to 111 muM, which places the more active compounds among the most potent known inhibitors of this target.	indenoisoquinolines	21-40	latexin	Homo sapiens	68-71
23259865-4	2013	The potencies of the indenoisoquinolines against Tdp1 ranged from 5 muM to 111 muM, which places the more active compounds among the most potent known inhibitors of this target.	indenoisoquinolines	21-40	latexin	Homo sapiens	79-82
21843105-5	2011	Tdp1 inhibitors should synergize not only with Top1-targeting drugs (camptothecins, indenoisoquinolines), but also with bleomycin, topoisomerase II (Top2) inhibitors (etoposide, doxorubicin) and DNA alkylating agents.	indenoisoquinolines	84-103	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
31409613-10	2019	RESULTS: CellMinerCDB reveals that SLFN11, which kills cells undergoing replicative stress, is a dominant drug determinant to the clinical indenoisoquinolines.	indenoisoquinolines	139-158	schlafen family member 11	Homo sapiens	35-41
31409613-11	2019	In addition, BRCA1-, BRCA2-, and PALB2-deficient cells were hypersensitive to the indenoisoquinolines.	indenoisoquinolines	82-101	BRCA1 DNA repair associated	Homo sapiens	13-18
31409613-11	2019	In addition, BRCA1-, BRCA2-, and PALB2-deficient cells were hypersensitive to the indenoisoquinolines.	indenoisoquinolines	82-101	BRCA2 DNA repair associated	Homo sapiens	21-26
31409613-11	2019	In addition, BRCA1-, BRCA2-, and PALB2-deficient cells were hypersensitive to the indenoisoquinolines.	indenoisoquinolines	82-101	partner and localizer of BRCA2	Homo sapiens	33-38
31409613-14	2019	CONCLUSIONS: Our results provide a rationale for molecularly designed clinical trials with the indenoisoquinolines as single agents and in combination with PARP inhibitors in HRD cancers expressing SLFN11.	indenoisoquinolines	95-114	schlafen family member 11	Homo sapiens	198-204
21464033-0	2011	Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.	indenoisoquinolines	89-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-85
20534341-2	2010	Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2alpha and Top2beta) are the targets of the widely used anticancer agents etoposide, anthracyclines (doxorubicin, daunorubicin), and mitoxantrone.	indenoisoquinolines	66-85	DNA topoisomerase II beta	Homo sapiens	201-209
20924131-9	2010	CONCLUSIONS: Our gammaH2AX assay is sufficiently accurate and sensitive to quantify gammaH2AX in tumor samples and will be used in correlative studies of two indenoisoquinolines in a phase I clinical trial at the National Cancer Institute.	indenoisoquinolines	158-177	H2A.X variant histone	Mus musculus	17-26
20630766-3	2010	The SAR of these compounds overlaps with indenoisoquinolines, suggesting that they may intercalate into the Top1-DNA complex similarly.	indenoisoquinolines	41-60	sarcosine dehydrogenase	Homo sapiens	4-7
24900212-4	2010	Indenoisoquinolines demonstrated potent inhibition of cell growth in the GIST882 patient-derived gastrointestinal stromal tumor cell line, accompanied by inhibition of both c-Kit transcription and KIT oncoprotein levels.	indenoisoquinolines	0-19	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	173-178
24900212-4	2010	Indenoisoquinolines demonstrated potent inhibition of cell growth in the GIST882 patient-derived gastrointestinal stromal tumor cell line, accompanied by inhibition of both c-Kit transcription and KIT oncoprotein levels.	indenoisoquinolines	0-19	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	197-200
19383846-9	2009	The trapping of Top1 cleavage complexes by indenoisoquinolines in cells results in the rapid and sustained phosphorylation of histone H2AX (gamma-H2AX).	indenoisoquinolines	43-62	H2A.X variant histone	Homo sapiens	126-138