PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31465983-4	2019	STUDY DESIGN/METHODS: The anti-arthritic ability of GL was demonstrated in vitro using IL-1beta stimulated bovine nasal cartilage model and in vivo Freund"s complete adjuvant-induced arthritic rat model.	guggulu extract	52-54	interleukin 1 beta	Bos taurus	87-95
31465983-7	2019	RESULTS: GL significantly inhibited the IL-1beta stimulated cartilage degradation in vitro by mitigating the MMPs activity, collagen degradation and secretion of pro-inflammatory mediators.	guggulu extract	9-11	interleukin 1 beta	Rattus norvegicus	40-48
28910310-7	2017	Gugulipid administration was associated with histological abnormalities in liver, increased alanine aminotransferase levels, lower hepatic SR-BI content, hypercholesterolemia due to increased HDL cholesterol levels, endothelial dysfunction, enhanced atherosclerosis, and accelerated death in animals with severe ischemic heart disease.	guggulu extract	0-9	scavenger receptor class B, member 1	Mus musculus	139-144
24013551-5	2014	The up regulation in nitrite release, cell proliferation, and release of IL-6 and IL-1 beta in LPS stimulated human astrocytoma cells were dose-dependently inhibited by co-treatment with guggulipid.	guggulu extract	187-197	interleukin 6	Homo sapiens	73-77
24013551-5	2014	The up regulation in nitrite release, cell proliferation, and release of IL-6 and IL-1 beta in LPS stimulated human astrocytoma cells were dose-dependently inhibited by co-treatment with guggulipid.	guggulu extract	187-197	interleukin 1 beta	Homo sapiens	82-91
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	glial fibrillary acidic protein	Homo sapiens	34-38
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	glial fibrillary acidic protein	Homo sapiens	109-113
21115635-6	2011	The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells.	guggulu extract	133-135	BCL2 apoptosis regulator	Homo sapiens	30-35
24058913-12	2013	SLN made up of guggul lipid showed good physical properties with acceptable stability.	guggulu extract	15-27	sarcolipin	Homo sapiens	0-3
22940226-3	2012	The present study demonstrated that, guggulipid and nimesulide (preferentially selective COX-2 inhibitor) treatment of rat astrocytoma cells, C6 for 24 h significantly decreased MPTP (400 muM) induced nitrative and oxidative stress and intracellular calcium ion (Ca(2+)) level.	guggulu extract	37-47	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	89-94
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	mitogen activated protein kinase 14	Rattus norvegicus	83-119
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	155-171
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	173-178
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	nitric oxide synthase 2	Rattus norvegicus	181-212
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	nitric oxide synthase 2	Rattus norvegicus	214-218
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	224-228
22940226-4	2012	Guggulipid and nimesulide also deactivated MPTP-induced P-p38 MAPK (Phosphorylated p38 mitogen-activated protein kinase) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and CHOP (C/EBP, homologous protein 10).	guggulu extract	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	230-258
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	tumor necrosis factor	Rattus norvegicus	140-149
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 1 beta	Rattus norvegicus	155-172
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 1 beta	Rattus norvegicus	174-182
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 6	Rattus norvegicus	224-237
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 6	Rattus norvegicus	239-243
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 1 alpha	Rattus norvegicus	249-267
21115635-4	2011	The GL-induced growth inhibition correlated with apoptosis induction as evidenced by an increase in cytoplasmic histone-associated DNA fragmentation and sub-G(0)/G(1)-DNA fraction, and cleavage of poly(ADP-ribose) polymerase.	guggulu extract	4-6	poly(ADP-ribose) polymerase 1	Homo sapiens	197-224
21115635-5	2011	The GL-induced apoptosis was associated with reactive oxygen species (ROS) production and c-Jun NH(2)-terminal kinase (JNK) activation.	guggulu extract	4-6	mitogen-activated protein kinase 8	Homo sapiens	90-117
21115635-5	2011	The GL-induced apoptosis was associated with reactive oxygen species (ROS) production and c-Jun NH(2)-terminal kinase (JNK) activation.	guggulu extract	4-6	mitogen-activated protein kinase 8	Homo sapiens	119-122
21163936-5	2011	The drugs under investigation included erlotinib, a small molecule inhibitor of the EGFR, and guggulipid, the extract of an Ayurvedic medicinal plant, which contains guggulsterone, a compound known to inhibit STAT3.	guggulu extract	94-104	signal transducer and activator of transcription 3	Mus musculus	209-214
23914993-0	2013	Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul.	guggulu extract	105-114	catenin beta 1	Homo sapiens	10-22
23914993-7	2013	The GL-induced apoptosis was associated with down-regulation of the beta-Catenin signaling pathway.	guggulu extract	4-6	catenin beta 1	Homo sapiens	68-80
23914993-8	2013	The decreased expression of Wnt/beta-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells.	guggulu extract	206-208	catenin beta 1	Homo sapiens	32-44
23914993-8	2013	The decreased expression of Wnt/beta-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells.	guggulu extract	206-208	cyclin D1	Homo sapiens	70-79
23914993-8	2013	The decreased expression of Wnt/beta-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells.	guggulu extract	206-208	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	81-86
23914993-8	2013	The decreased expression of Wnt/beta-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells.	guggulu extract	206-208	transcription factor 4	Homo sapiens	182-187
23914993-9	2013	The GL treatment resulted in a significant reduction of beta-Catenin /TCF-4 complex in both of the cancer cells.	guggulu extract	4-6	catenin beta 1	Homo sapiens	56-68
23914993-9	2013	The GL treatment resulted in a significant reduction of beta-Catenin /TCF-4 complex in both of the cancer cells.	guggulu extract	4-6	transcription factor 4	Homo sapiens	70-75
23914993-10	2013	The GL-induced apoptotic cell death was significantly enhanced by RNA Interference of beta-Catenin and TCF-4.	guggulu extract	4-6	catenin beta 1	Homo sapiens	86-98
23914993-10	2013	The GL-induced apoptotic cell death was significantly enhanced by RNA Interference of beta-Catenin and TCF-4.	guggulu extract	4-6	transcription factor 4	Homo sapiens	103-108
23914993-12	2013	CONCLUSION: The present study indicates that the beta-Catenin signaling pathway is the target for GL-induced growth inhibition and apoptosis in human breast cancer.	guggulu extract	98-100	catenin beta 1	Homo sapiens	49-61
22940226-5	2012	At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions.	guggulu extract	57-67	interleukin 1 alpha	Rattus norvegicus	269-278
21461920-0	2011	Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6.	guggulu extract	0-10	nuclear factor kappa B subunit 1	Rattus norvegicus	105-110
21461920-0	2011	Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6.	guggulu extract	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	115-119
21115635-6	2011	The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells.	guggulu extract	133-135	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
21115635-6	2011	The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells.	guggulu extract	133-135	BCL2 antagonist/killer 1	Homo sapiens	60-63
21115635-6	2011	The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells.	guggulu extract	133-135	BCL2 apoptosis regulator	Homo sapiens	96-101
21115635-6	2011	The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells.	guggulu extract	133-135	BCL2 apoptosis regulator	Homo sapiens	96-101
21115635-7	2011	SV40 immortalized mouse embryonic fibroblasts derived from Bax-Bak double-knockout mice were significantly more resistant to GL-induced cell killing compared with wild-type cells.	guggulu extract	125-127	BCL2-associated X protein	Mus musculus	59-62
21115635-7	2011	SV40 immortalized mouse embryonic fibroblasts derived from Bax-Bak double-knockout mice were significantly more resistant to GL-induced cell killing compared with wild-type cells.	guggulu extract	125-127	BCL2-antagonist/killer 1	Mus musculus	63-66
21115635-9	2011	The GL treatment caused the activation of JNK that functioned upstream of Bax activation in apoptosis response.	guggulu extract	4-6	mitogen-activated protein kinase 8	Homo sapiens	42-45
21115635-9	2011	The GL treatment caused the activation of JNK that functioned upstream of Bax activation in apoptosis response.	guggulu extract	4-6	BCL2 associated X, apoptosis regulator	Homo sapiens	74-77
21115635-10	2011	The GL-induced conformational change of Bax and apoptosis were significantly suppressed by genetic suppression of JNK activation.	guggulu extract	4-6	BCL2 associated X, apoptosis regulator	Homo sapiens	40-43
21115635-10	2011	The GL-induced conformational change of Bax and apoptosis were significantly suppressed by genetic suppression of JNK activation.	guggulu extract	4-6	mitogen-activated protein kinase 8	Homo sapiens	114-117
21115635-11	2011	In conclusion, the present study indicates that ROS-dependent apoptosis by GL is regulated by JNK signaling axis.	guggulu extract	75-77	mitogen-activated protein kinase 8	Homo sapiens	94-97
20018235-5	2010	Both guggulipid and nimesulide significantly attenuated nitrite release, ROS generation and also down regulated expressions of COX-2, GFAP and TNF-alpha.	guggulu extract	5-15	tumor necrosis factor	Rattus norvegicus	143-152
18926687-0	2009	Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.	guggulu extract	150-160	leptin	Mus musculus	164-167
20018235-5	2010	Both guggulipid and nimesulide significantly attenuated nitrite release, ROS generation and also down regulated expressions of COX-2, GFAP and TNF-alpha.	guggulu extract	5-15	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	127-132
20018235-5	2010	Both guggulipid and nimesulide significantly attenuated nitrite release, ROS generation and also down regulated expressions of COX-2, GFAP and TNF-alpha.	guggulu extract	5-15	glial fibrillary acidic protein	Rattus norvegicus	134-138
18926687-0	2009	Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.	guggulu extract	150-160	leptin	Mus musculus	172-175
18926687-3	2009	Both guggulipid (EC(50)=0.82 microg/ml) and commipheric acid (EC(50)=0.26 microg/ml) activated human peroxisome proliferator-activated receptor alpha (PPARalpha) in COS-7 cells transiently transfected with the receptor and a reporter gene construct.	guggulu extract	5-15	peroxisome proliferator activated receptor alpha	Homo sapiens	101-149
18926687-3	2009	Both guggulipid (EC(50)=0.82 microg/ml) and commipheric acid (EC(50)=0.26 microg/ml) activated human peroxisome proliferator-activated receptor alpha (PPARalpha) in COS-7 cells transiently transfected with the receptor and a reporter gene construct.	guggulu extract	5-15	peroxisome proliferator activated receptor alpha	Homo sapiens	151-160
18926687-4	2009	Similarly, both guggulipid (EC(50)=2.3 microg/ml) and commipheric acid (EC(50)=0.3 microg/ml) activated PPARgamma and both promoted the differentiation of 3T3 L1 preadipocytes to adipocytes.	guggulu extract	16-26	peroxisome proliferator activated receptor gamma	Mus musculus	104-113
18926687-5	2009	Guggulipid (EC(50)=0.66 microg/ml), but not commipheric acid, activated liver X receptor alpha (LXRalpha).	guggulu extract	0-10	nuclear receptor subfamily 1, group H, member 3	Mus musculus	72-94
18926687-7	2009	Guggulipid (20 g/kg diet) improved glucose tolerance in female Lep(ob)/Lep(ob) mice.	guggulu extract	0-10	leptin	Mus musculus	63-66
18926687-7	2009	Guggulipid (20 g/kg diet) improved glucose tolerance in female Lep(ob)/Lep(ob) mice.	guggulu extract	0-10	leptin	Mus musculus	71-74
18926687-10	2009	These results raise the possibility that guggulipid has anti-diabetic activity due partly to commipheric acid"s PPARalpha/gamma agonism, but the systemic bioavailability of orally dosed, pure commipheric acid appears poor.	guggulu extract	41-51	peroxisome proliferator activated receptor alpha	Mus musculus	112-121
15075359-10	2004	Pregnane X receptor activation is known to cause herb-drug interactions, and our data suggest that gugulipid therapy should be used cautiously in patients taking prescription medications that are metabolized by CYP3A family members.	guggulu extract	99-108	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-19
15075359-10	2004	Pregnane X receptor activation is known to cause herb-drug interactions, and our data suggest that gugulipid therapy should be used cautiously in patients taking prescription medications that are metabolized by CYP3A family members.	guggulu extract	99-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	211-216
17477963-9	2007	Gugulipid was investigated for its effect on learning and memory, parameters of oxidative stress (GSH and MDA) and acetylcholinesterase (AChE) activity in the STZ (ic)-treated mice.	guggulu extract	0-9	acetylcholinesterase	Mus musculus	115-135
17477963-20	2007	Gugulipid treatment caused significant decrease in AChE activity, low level of MDA and high concentration of GSH in brain following STZ (ic) as compared to vehicle administration in STZ (ic)-treated mice.	guggulu extract	0-9	acetylcholinesterase	Mus musculus	51-55
17477963-21	2007	The study demonstrated that gugulipid has significant protective affect against streptozotocin-induced memory deficits model of dementia that can be attributed to anti-oxidant and anti-AChE activity of gugulipid.	guggulu extract	28-37	acetylcholinesterase	Mus musculus	185-189
17477963-21	2007	The study demonstrated that gugulipid has significant protective affect against streptozotocin-induced memory deficits model of dementia that can be attributed to anti-oxidant and anti-AChE activity of gugulipid.	guggulu extract	202-211	acetylcholinesterase	Mus musculus	185-189
15833898-4	2005	The active ingredient in gugulipid is guggulsterone, a plant sterol compound recently identified as a pregnane X receptor (PXR; NR1I2) ligand.	guggulu extract	25-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	102-121
15833898-4	2005	The active ingredient in gugulipid is guggulsterone, a plant sterol compound recently identified as a pregnane X receptor (PXR; NR1I2) ligand.	guggulu extract	25-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	123-126
15833898-4	2005	The active ingredient in gugulipid is guggulsterone, a plant sterol compound recently identified as a pregnane X receptor (PXR; NR1I2) ligand.	guggulu extract	25-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	128-133
12525500-8	2003	Consistent with the results in HepG2, guggulipid treatment in Fisher rats increased BSEP mRNA.	guggulu extract	38-48	ATP binding cassette subfamily B member 11	Rattus norvegicus	84-88