PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30537230-2	2019	Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recognize immune-evasive tumor cells and kill them via the FasL-Fas interaction.	Tilorone	42-50	Fas ligand	Homo sapiens	205-209
31094457-5	2019	RESULTS: A decrease in the frequency of ARVI in patients with CHF treated with Amixin was found, which was accompanied by a decrease in the severity of subclinical inflammation by reducing the production of proinflammatory (IL-1beta) and increasing the production of anti-inflammatory (IL-10) cytokines, reducing neurohumoral activation (reducing levels of aldosterone and Nt-proBNP), increasing the level of alpha- and gamma-interferon.	Tilorone	79-85	interleukin 1 beta	Homo sapiens	224-232
31094457-5	2019	RESULTS: A decrease in the frequency of ARVI in patients with CHF treated with Amixin was found, which was accompanied by a decrease in the severity of subclinical inflammation by reducing the production of proinflammatory (IL-1beta) and increasing the production of anti-inflammatory (IL-10) cytokines, reducing neurohumoral activation (reducing levels of aldosterone and Nt-proBNP), increasing the level of alpha- and gamma-interferon.	Tilorone	79-85	interleukin 10	Homo sapiens	286-291
24841903-0	2014	Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.	Tilorone	65-89	chromobox 8	Homo sapiens	28-31
26633340-0	2015	An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-alpha Inducing Activity.	Tilorone	34-58	interferon alpha	Mus musculus	72-81
26633340-5	2015	Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-alpha (IFN-alpha) in mice within 12 h, and the peak level was observed until 24 h. This fruitful work has resulted in tilorone dihydrochloride becoming available in large-scale and wide application in clinics, which has a good pharmaceutical development prospects.	Tilorone	29-53	interferon alpha	Mus musculus	98-114
26633340-5	2015	Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-alpha (IFN-alpha) in mice within 12 h, and the peak level was observed until 24 h. This fruitful work has resulted in tilorone dihydrochloride becoming available in large-scale and wide application in clinics, which has a good pharmaceutical development prospects.	Tilorone	29-53	interferon alpha	Mus musculus	116-125
26633340-5	2015	Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-alpha (IFN-alpha) in mice within 12 h, and the peak level was observed until 24 h. This fruitful work has resulted in tilorone dihydrochloride becoming available in large-scale and wide application in clinics, which has a good pharmaceutical development prospects.	Tilorone	227-251	interferon alpha	Mus musculus	98-114
26633340-5	2015	Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-alpha (IFN-alpha) in mice within 12 h, and the peak level was observed until 24 h. This fruitful work has resulted in tilorone dihydrochloride becoming available in large-scale and wide application in clinics, which has a good pharmaceutical development prospects.	Tilorone	227-251	interferon alpha	Mus musculus	116-125
24841903-0	2014	Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.	Tilorone	65-89	cyclin dependent kinase 5	Homo sapiens	134-159
24841903-6	2014	Screening of 3,360 compounds identified rutilantin, ethacridine lactate and cetalkonium chloride as compounds that selectively target PC3 control cells and a tilorone analog as a selective inhibitor of PC3 CDK5dn cells.	Tilorone	158-166	chromobox 8	Homo sapiens	202-205
24841903-6	2014	Screening of 3,360 compounds identified rutilantin, ethacridine lactate and cetalkonium chloride as compounds that selectively target PC3 control cells and a tilorone analog as a selective inhibitor of PC3 CDK5dn cells.	Tilorone	158-166	cyclin dependent kinase 5	Homo sapiens	206-210
24841903-8	2014	Validation experiments confirmed that tilorone treatment resulted in decreased PC3 cell growth and invasion; PC3 cells with inactive CDK5 were inhibited more effectively.	Tilorone	38-46	chromobox 8	Homo sapiens	79-82
24841903-9	2014	Future studies are needed to unravel the mechanism of action of tilorone in CDK5 deficient prostate cancer cells and to test combination therapies with tilorone and a CDK5 inhibitor for its potential use in clinical practice.	Tilorone	64-72	cyclin dependent kinase 5	Homo sapiens	76-80
22281189-0	2012	SAR of alpha7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.	Tilorone	55-63	sarcosine dehydrogenase	Homo sapiens	0-3
23258233-0	2013	Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo.	Tilorone	35-43	bone morphogenetic protein 1	Homo sapiens	0-26
23258233-6	2013	The most promising drug candidate, tilorone, induced BMP signaling in the reporter cells and increased the expression of BMP-7 and a BMP target gene, Id3, in lung epithelial A549 cells.	Tilorone	35-43	bone morphogenetic protein 1	Homo sapiens	53-56
23258233-6	2013	The most promising drug candidate, tilorone, induced BMP signaling in the reporter cells and increased the expression of BMP-7 and a BMP target gene, Id3, in lung epithelial A549 cells.	Tilorone	35-43	bone morphogenetic protein 7	Mus musculus	121-126
23258233-6	2013	The most promising drug candidate, tilorone, induced BMP signaling in the reporter cells and increased the expression of BMP-7 and a BMP target gene, Id3, in lung epithelial A549 cells.	Tilorone	35-43	bone morphogenetic protein 1	Homo sapiens	121-124
23258233-6	2013	The most promising drug candidate, tilorone, induced BMP signaling in the reporter cells and increased the expression of BMP-7 and a BMP target gene, Id3, in lung epithelial A549 cells.	Tilorone	35-43	inhibitor of DNA binding 3	Mus musculus	150-153
23258233-7	2013	In a mouse model of pulmonary fibrosis, tilorone decreased lung hydroxyproline content and the expression of collagen genes Col1A1 and Col3A1.	Tilorone	40-48	collagen, type I, alpha 1	Mus musculus	124-130
23258233-7	2013	In a mouse model of pulmonary fibrosis, tilorone decreased lung hydroxyproline content and the expression of collagen genes Col1A1 and Col3A1.	Tilorone	40-48	collagen, type III, alpha 1	Mus musculus	135-141
18157163-5	2008	KEY RESULTS: Tilorone bound alpha7 nAChR (IC(50) 110 nM) with high selectivity relative to alpha4beta2 (IC(50) 70 000 nM), activated human alpha7 nAChR with an EC(50) value of 2.5 microM and maximal response of 67% relative to acetylcholine, and showed little agonist effect at human alpha3beta4 or alpha4beta2 nAChRs.	Tilorone	13-21	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	35-40
18157163-5	2008	KEY RESULTS: Tilorone bound alpha7 nAChR (IC(50) 110 nM) with high selectivity relative to alpha4beta2 (IC(50) 70 000 nM), activated human alpha7 nAChR with an EC(50) value of 2.5 microM and maximal response of 67% relative to acetylcholine, and showed little agonist effect at human alpha3beta4 or alpha4beta2 nAChRs.	Tilorone	13-21	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	146-151
18157163-9	2008	CONCLUSIONS AND IMPLICATIONS: Tilorone, known as an interferon inducer, is a selective alpha7 nAChR agonist, suggesting utility of the fluorenone pharmacophore for the development of alpha7 nAChR selective agonists.	Tilorone	30-38	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	94-99
18157163-9	2008	CONCLUSIONS AND IMPLICATIONS: Tilorone, known as an interferon inducer, is a selective alpha7 nAChR agonist, suggesting utility of the fluorenone pharmacophore for the development of alpha7 nAChR selective agonists.	Tilorone	30-38	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	190-195
12414762-5	2002	The results demonstrate that tilorone treatment elicits, by a direct effect, the production of proinflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-alpha], and IL-12) by splenic macrophages.	Tilorone	29-37	interleukin 6	Mus musculus	122-135
18439305-6	2008	When an oral IFN-alpha inducer tilorone analog, R11567DA, was administered to SPF mice, IFN-alpha was induced rapidly in the LI at 4 h, whereas no IFN-alpha protein was detected in the small intestine (SI) or blood.	Tilorone	31-39	interferon alpha	Mus musculus	13-22
18439305-6	2008	When an oral IFN-alpha inducer tilorone analog, R11567DA, was administered to SPF mice, IFN-alpha was induced rapidly in the LI at 4 h, whereas no IFN-alpha protein was detected in the small intestine (SI) or blood.	Tilorone	31-39	interferon alpha	Mus musculus	88-97
18439305-6	2008	When an oral IFN-alpha inducer tilorone analog, R11567DA, was administered to SPF mice, IFN-alpha was induced rapidly in the LI at 4 h, whereas no IFN-alpha protein was detected in the small intestine (SI) or blood.	Tilorone	31-39	interferon alpha	Mus musculus	88-97
18028287-5	2008	A comparison of responses in naive mouse NK cells and NK cells pre-activated with the type I interferon-inducer tilorone demonstrated a dramatic influence of pre-activation, allowing potent degranulation and IFN-gamma responses to NKG2D mediated stimulation that were not observed with naive NK cells.	Tilorone	112-120	interferon gamma	Mus musculus	208-217
18028287-5	2008	A comparison of responses in naive mouse NK cells and NK cells pre-activated with the type I interferon-inducer tilorone demonstrated a dramatic influence of pre-activation, allowing potent degranulation and IFN-gamma responses to NKG2D mediated stimulation that were not observed with naive NK cells.	Tilorone	112-120	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	231-236
15848749-2	2005	In pursuing research on the antiviral, interferon (IFN)-inducing tilorone congeners, a new series of fluoren-carboxyhydroxyesters has been prepared and biologically explored.	Tilorone	65-73	interferon alpha 1	Homo sapiens	51-54
12414762-5	2002	The results demonstrate that tilorone treatment elicits, by a direct effect, the production of proinflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-alpha], and IL-12) by splenic macrophages.	Tilorone	29-37	interleukin 6	Mus musculus	137-141
12414762-5	2002	The results demonstrate that tilorone treatment elicits, by a direct effect, the production of proinflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-alpha], and IL-12) by splenic macrophages.	Tilorone	29-37	tumor necrosis factor	Mus musculus	144-171
12414762-5	2002	The results demonstrate that tilorone treatment elicits, by a direct effect, the production of proinflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-alpha], and IL-12) by splenic macrophages.	Tilorone	29-37	tumor necrosis factor	Mus musculus	173-182
1590774-5	1992	RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver.	Tilorone	148-156	interferon alpha	Mus musculus	40-56
8287618-5	1994	The effect was not due to direct toxicity of the tilorone analog on tumor cells, but instead was dependent on NK cells; this was suggested by the finding that treatment of mice with anti-asialo GM1 abrogated the effect of the tilorone analog (RMI 10,874DA compound).	Tilorone	49-57	coenzyme Q10A	Mus musculus	194-197
8287618-5	1994	The effect was not due to direct toxicity of the tilorone analog on tumor cells, but instead was dependent on NK cells; this was suggested by the finding that treatment of mice with anti-asialo GM1 abrogated the effect of the tilorone analog (RMI 10,874DA compound).	Tilorone	226-234	coenzyme Q10A	Mus musculus	194-197
1590774-5	1992	RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver.	Tilorone	148-156	interferon alpha	Mus musculus	58-67
2621325-0	1989	Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.	Tilorone	118-126	interleukin 1 beta	Homo sapiens	21-39
1567485-0	1992	Immunomodulation and drug acetylation: influence of the immunomodulator tilorone on hepatic, renal and blood N-acetyltransferase activity and on hepatic cytosolic acetyl coenzyme A content.	Tilorone	72-80	N-acetyltransferase 1	Rattus norvegicus	109-128
1724584-2	1991	A comparative evaluation of L-1 (acridanon) and amixin (fluorenon) showed L-1 to have more marked interferon-inducing properties.	Tilorone	48-54	L1 cell adhesion molecule	Homo sapiens	74-77
1724584-4	1991	L-1 induced IF synthesis most actively after subcutaneous inoculation, amixin after oral administration.	Tilorone	71-77	L1 cell adhesion molecule	Homo sapiens	0-3
33778258-11	2021	We used microscale thermophoresis to test the binding of these molecules to the spike protein, and tilorone and pyronaridine bind to the spike receptor binding domain protein with K d values of 339 and 647 nM, respectively.	Tilorone	99-107	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	137-142
34705177-0	2021	Effect of Tilorone on the Dynamics of Viral Load and the Levels of Interferons and Interleukin-1beta in the Lung Tissue and Blood Serum of Mice with Experimental Influenza.	Tilorone	10-18	interleukin 1 beta	Mus musculus	83-100
34705177-1	2021	We studied the effect of tilorone on the dynamics of IFNalpha, IFNgamma, and IL-1beta levels in the lung tissue and blood serum in relation to viral load in the lungs of BALB/c mice with pneumonia caused by influenza virus A/Aichi/2/68 (H3N2).	Tilorone	25-33	interferon alpha	Mus musculus	53-61
34705177-1	2021	We studied the effect of tilorone on the dynamics of IFNalpha, IFNgamma, and IL-1beta levels in the lung tissue and blood serum in relation to viral load in the lungs of BALB/c mice with pneumonia caused by influenza virus A/Aichi/2/68 (H3N2).	Tilorone	25-33	interferon gamma	Mus musculus	63-71
34705177-1	2021	We studied the effect of tilorone on the dynamics of IFNalpha, IFNgamma, and IL-1beta levels in the lung tissue and blood serum in relation to viral load in the lungs of BALB/c mice with pneumonia caused by influenza virus A/Aichi/2/68 (H3N2).	Tilorone	25-33	interleukin 1 alpha	Mus musculus	77-85
3795024-1	1986	A wide variety of immunomodulators, including the synthetic interferon inducer tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one), have been shown to inhibit cytochrome P-450-dependent drug metabolism in vitro.	Tilorone	79-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	163-179
3795024-1	1986	A wide variety of immunomodulators, including the synthetic interferon inducer tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one), have been shown to inhibit cytochrome P-450-dependent drug metabolism in vitro.	Tilorone	89-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	163-179
2433236-9	1986	However, when given intranasally 7 days before an oral dose of tilorone, increased levels of IFN in lung suspensions are observed.	Tilorone	63-71	interferon alpha 1	Homo sapiens	93-96
7215004-3	1981	Under defined experimental conditions tilorone hydrochloride also prevented pulmonary metastases from a subcutaneous tumour graft of epithelioma SP1 and mammary carcinoma SP22, as measured by an increased survival or treated rats.	Tilorone	38-60	Parkinsonism associated deglycase	Rattus norvegicus	171-175
6712731-7	1984	Thus, in maternal livers tilorone depressed cytochrome P-450 and AP N-demethylase activity in non-induced and PB-, MC- and PCN-induced rats and BP hydroxylase activity in the induced animals; BP hydroxylase activity was not depressed in non-induced maternal livers.	Tilorone	25-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
6712731-10	1984	Fetal hepatic cytochrome P-450 and monooxygenase activities were increased by tilorone in PB- and PCN-induced rats but not in non-induced or MC-induced animals.	Tilorone	78-86	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
6712732-8	1984	By day 7 postpartum, the cytochrome P-450 content and all three monooxygenase activities were depressed in rats that had received tilorone on days 1 and 2 postpartum.	Tilorone	130-138	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
843913-8	1977	In passive EAE, the most significant increase occurred only in the lower spinal cord for cathepsins A and C, and fourthly, in monocytic EAE induced by tilorone, there was an exceptionally large, 3-fold increase in cathepsin C in lower cord as compared to a 1.5-2 fold increase for other cathepsins.	Tilorone	151-159	cathepsin C	Homo sapiens	214-225
6817439-2	1981	Inducers of alpha or beta (Type I) interferons, such as Tilorone-HCl, statalon, mengovirus and others, suppressed the cytochrome P-450 system of rats or mice after administration.	Tilorone	56-68	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	118-134
220421-0	1979	Reticuloendothelial cells as the site of production of MIF induced by tilorone hydrochloride.	Tilorone	70-92	macrophage migration inhibitory factor	Homo sapiens	55-58
17988-0	1977	Effect of tilorone hydrochloride on graft-versus-host (GvH) reaction in mice.	Tilorone	10-32	graft versus host regulation	Mus musculus	55-58
17988-1	1977	The effects of tilorone hydrochloride (TH), a powerful interferonogenic agent exhibiting also immune modulatory properties, on GvH reaction was studied, using the popliteal lymph node assay in mice.	Tilorone	15-37	graft versus host regulation	Mus musculus	127-130
17988-1	1977	The effects of tilorone hydrochloride (TH), a powerful interferonogenic agent exhibiting also immune modulatory properties, on GvH reaction was studied, using the popliteal lymph node assay in mice.	Tilorone	39-41	graft versus host regulation	Mus musculus	127-130
17988-4	1977	However, since normal parental lymphocytes are prepared for an enhanced GvH reactivity by addition of TH-treated macrophages, a stimulatory effect of the latter cells via macrophage-derived mediators, induced by TH, is suggested.	Tilorone	102-104	graft versus host regulation	Mus musculus	72-75
339871-2	1977	application of tilorone [2, 7-bis/2-diethylaminoethoxy/-fluoren-9-one dihydrochloride] to ABD2F1 mice demonstrated both interferon and migration inhibitory (MIF) activity.	Tilorone	15-23	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	157-160
339871-2	1977	application of tilorone [2, 7-bis/2-diethylaminoethoxy/-fluoren-9-one dihydrochloride] to ABD2F1 mice demonstrated both interferon and migration inhibitory (MIF) activity.	Tilorone	25-85	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	157-160
339871-4	1977	The physiochemical characteristics of tilorone-induced MIF (heat and pH lability, molecular size) are compared with those of MIF generated in in vitro lymphocyte cultures.	Tilorone	38-46	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	55-58
6226-0	1976	Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride).	Tilorone	81-89	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	26-57
6226-0	1976	Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride).	Tilorone	91-151	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	26-57
6226-3	1976	After a single oral dose of tilorone-HCl (50 mg/kg) a loss of 38% of the microsomal cytochrome P-450 and 25% of the ethylmorphine N-demethylase activity was observed within 24 hr; recovery was complete within 8 to 10 days.	Tilorone	28-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
6226-5	1976	In vitro, tilorone-HCl showed no inhibitory effect on microsomal drug metabolism nod did it affect the cytochrome P-450 content of the microsomes.	Tilorone	10-22	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	103-119
33400519-0	2021	The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase.	Tilorone	19-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-87
1200845-0	1975	Comparison of the ability of small molecular interferon inducers: tilorone and acridine drugs.	Tilorone	66-74	interferon	Gallus gallus	45-55
1200845-3	1975	Acranil, given parenterally, proved to be as strong as tilorone regarding interferon stimulation, in spite of the presence of only one side chain in the Acrainl molecule.	Tilorone	55-63	interferon	Gallus gallus	74-84
33400519-4	2021	High-throughput screens for the eel AChE inhibitor model identified several molecules including tilorone, an antiviral drug that is well-established outside of the United States, as a newly identified nanomolar AChE inhibitor.	Tilorone	96-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
33400519-4	2021	High-throughput screens for the eel AChE inhibitor model identified several molecules including tilorone, an antiviral drug that is well-established outside of the United States, as a newly identified nanomolar AChE inhibitor.	Tilorone	96-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215
33400519-8	2021	This study suggests there may be a potential role for repurposing tilorone or its derivatives in conditions that benefit from AChE inhibition.	Tilorone	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130