PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2553554-4	1989	These results suggested that a control mechanism for MAO activity during pregnancy might exist due to an increase in catecholamine and that the beta 2-effect of ritodrine induced a lowering in serum calcium and magnesium levels.	Ritodrine	161-170	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	144-150
2920966-0	1989	Influence of ritodrine on plasma steroids and human placental lactogen levels in third-trimester pregnancies.	Ritodrine	13-22	chorionic somatomammotropin hormone 2	Homo sapiens	52-70
2920966-2	1989	Ritodrine administered at a constant rate of 200 micrograms/min for 3 h, injected intramuscularly 8 x 10 mg/day for 5 days or given orally in doses of 6 x 20 mg/day for 10 days resulted in a significant decrease in the steroid hormone concentration and a significant elevation of HPL levels.	Ritodrine	0-9	galectin 1	Homo sapiens	280-283
3197364-1	1988	Ritodrine is a beta 2-adrenergic agonist that is used clinically for the management of preterm labor.	Ritodrine	0-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-21
3197364-2	1988	The beta 2 activity of ritodrine produces the relaxation of smooth muscles and is believed to act directly on the beta 2-receptors of the myometrium.	Ritodrine	23-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-10
3197364-2	1988	The beta 2 activity of ritodrine produces the relaxation of smooth muscles and is believed to act directly on the beta 2-receptors of the myometrium.	Ritodrine	23-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	114-120
3145484-4	1988	Ritodrine infusion produced a 1.7-fold elevation in fetal serum glucose level, from 23 +/- 5 to 42 +/- 15 mg/dl, and a 2-fold elevation in serum insulin level, from 16 +/- 5 to 34 +/- 8 mg/ml, p less than 0.01.	Ritodrine	0-9	LOC105613195	Ovis aries	145-152
3666269-1	1987	In a clinical study of 17 pregnant women treated with ritodrine, a beta 2-sympathomimetic agent used for tocolysis, thyroid hormone status was assessed longitudinally.	Ritodrine	54-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	67-73
3666270-5	1987	In developing an infusion scheme with a loading dose for ritodrine, this cumulation t1/2 of 1 h should be taken into account.	Ritodrine	57-66	interleukin 1 receptor like 1	Homo sapiens	84-93
3429972-7	1987	3) Blood and uterine muscle levels of c-AMP were increased in pregnant rats that had been given ritodrine prior to hysterectomy, and there was no inhibitory effect of ritodrine in comparison with pregnant rats that had not been given the agent.	Ritodrine	96-105	cathelicidin antimicrobial peptide	Rattus norvegicus	38-43
3652457-1	1987	In a clinical study of 17 pregnant women treated with ritodrine, a beta-2-sympathomimetic agent used for tocolysis, thyroid hormone status was assessed longitudinally.	Ritodrine	54-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	67-73
3652457-8	1987	These beta-2-mimetic variations may explain, to a certain degree, the unwanted chronotropic cardiac side effects of ritodrine and necessitates much care in using this therapy in hyperthyroidic patients.	Ritodrine	116-125	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	6-12
3963086-1	1986	Ritodrine hydrochloride, a beta-sympathomimetic treatment for premature labor, has been associated with the development of pulmonary edema, various metabolic derangements, myocardial ischemia, and infarction.	Ritodrine	0-23	amyloid beta precursor protein	Homo sapiens	25-31
2864408-4	1985	There was a progressive rise in plasma glucose concentration and plasma insulin concentration during ritodrine hydrochloride infusion compared with the control (saline) infusion.	Ritodrine	101-124	insulin	Homo sapiens	72-79
2864408-6	1985	The ritodrine hydrochloride-infused animals had a progressive rise in [insulin/glucose] compared with our prior studies in the newborn lamb, suggesting direct stimulation of pancreatic beta cell secretion.	Ritodrine	4-27	insulin	Homo sapiens	71-78
3883263-0	1985	Metabolic disturbances during intravenous use of ritodrine: increased insulin levels and hypokalemia.	Ritodrine	49-58	insulin	Homo sapiens	70-77
6355419-1	1983	Because of its effects on the cardiovascular and renin-angiotensin systems and on fluid and electrolyte homeostasis, maternal administration of ritodrine to inhibit preterm labor may cause significant alterations in renal function in the newborn infant.	Ritodrine	144-153	renin	Homo sapiens	49-54
6355419-4	1983	The infants whose mothers had received ritodrine had significantly lower inulin clearances and higher plasma renin activity and urinary arginine vasopressin excretion on day 1 but not on day 6.	Ritodrine	39-48	renin	Homo sapiens	109-114
6136361-13	1983	To date, a betamimetic with selective beta 2 effects, such as terbutaline or ritodrine, is the most valuable agent for inhibition of preterm labor.	Ritodrine	77-86	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-44
6125547-6	1982	The c-AMP values in uterus, placenta and fetus increased as they did after treatment with ritodrine.	Ritodrine	90-99	cathelicidin antimicrobial peptide	Rattus norvegicus	4-9
6273481-3	1981	beta 2-effects of terbutaline and ritodrine in the treatment of preterm labor.	Ritodrine	34-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
6273481-6	1981	2) The levels of c-AMP and c-GMP in the blood after administration of terbutaline or ritodrine increased and showed dose-response.	Ritodrine	85-94	cathelicidin antimicrobial peptide	Homo sapiens	17-32
6268718-5	1981	2) When the changes in the maternal serum c-AMP and c-GMP levels after the administration of ritodrine were examined, these results coincided with those obtained experiments in vitro.	Ritodrine	93-102	cathelicidin antimicrobial peptide	Rattus norvegicus	42-47
6268718-7	1981	The c-AMP and c-GMP levels of placenta, liver, uterus and fetus showed similar patterns, especially c-AMP in the uterine and fetal tissues increased when ritodrine was administered.	Ritodrine	154-163	cathelicidin antimicrobial peptide	Rattus norvegicus	4-9
6268718-7	1981	The c-AMP and c-GMP levels of placenta, liver, uterus and fetus showed similar patterns, especially c-AMP in the uterine and fetal tissues increased when ritodrine was administered.	Ritodrine	154-163	cathelicidin antimicrobial peptide	Rattus norvegicus	100-105
7262636-0	1981	Plasma steroids and human placental lactogen level changes in late pregnancy in association with intravenous ritodrine administration.	Ritodrine	109-118	chorionic somatomammotropin hormone 2	Homo sapiens	26-44
572891-1	1979	A 31-year-old healthy woman received Ritodrine (Pre-Par) from the 26th week of gestation because of twin pregnancy.	Ritodrine	37-46	jumping translocation breakpoint	Homo sapiens	52-55
476199-0	1979	Maternal and fetal plasma renin activity during ritodrine infusion to the mother.	Ritodrine	48-57	renin	Homo sapiens	26-31
476199-1	1979	The effect of ritodrine to the mother on plasma renin activity (PRA) in the mother and fetus was examined in 10 mothers coming to elective cesarean section.	Ritodrine	14-23	renin	Homo sapiens	48-53
31167-3	1978	A low dose of ritodrine, a beta2 adrenergic agent, caused a rise of PRA but no simultaneous rise in heart rate; this suggests that beta2 activity is involved in renin release.	Ritodrine	14-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-32
31167-3	1978	A low dose of ritodrine, a beta2 adrenergic agent, caused a rise of PRA but no simultaneous rise in heart rate; this suggests that beta2 activity is involved in renin release.	Ritodrine	14-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-136
31167-3	1978	A low dose of ritodrine, a beta2 adrenergic agent, caused a rise of PRA but no simultaneous rise in heart rate; this suggests that beta2 activity is involved in renin release.	Ritodrine	14-23	renin	Homo sapiens	161-166
696985-3	1978	Our patient-material consists of parturients, who were given a beta2-sympathomimetic, ritodrine, immediately before caesarean section performed under combined general anaesthesia.	Ritodrine	86-95	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	63-68
356601-4	1978	Plasma insulin levels similarly did not increase in the placebo but significantly rose in the ritodrine group by 30 minutes, peaked at 2 1/2 hours, and remained elevated throughout the infusion.	Ritodrine	94-103	insulin	Homo sapiens	7-14
203880-3	1978	Ritodrine was more potent than isoxsuprine in increasing the circulating levels of cyclic AMP, glucose, insulin, and triglycerides.	Ritodrine	0-9	insulin	Homo sapiens	104-111
641319-2	1978	The contractions can be stopped by a beta sympatho-mimetic drug (Ritodrine) easily and the immediate problem is resolved, in that the woman is allowed a rest during which she can recover for a few hours.	Ritodrine	65-74	amyloid beta precursor protein	Homo sapiens	35-41
851767-0	1977	Insulin requirements in pregnant diabetics with premature labour controlled by ritodrine.	Ritodrine	79-88	insulin	Homo sapiens	0-7
558765-4	1977	The potency of the two compounds exceeded by ten times that of ritodrine (a beta adrenergic stimulant), the efficacy was slightly higher (20-30%) than that of papaverine.	Ritodrine	63-72	amyloid beta precursor protein	Homo sapiens	74-80
1013850-0	1976	A comparison of the uterine beta2-adrenoreceptor selectivity of fenoterol, hexoprenaline, ritodrine and salbutamol.	Ritodrine	90-99	adrenoceptor beta 2	Homo sapiens	28-48
1013850-1	1976	A study was undertaken to compare the uterine beta2-adrenoreceptor selectivity of fenoterol, hexoprenaline, ritodrine and salbutamol.	Ritodrine	108-117	adrenoceptor beta 2	Homo sapiens	46-66
4397654-1	1971	A double-blind placebo-controlled multicentre study with ritodrine, a beta-mimetic uterine relaxant, has been performed in 91 patients in premature labour.	Ritodrine	57-66	amyloid beta precursor protein	Homo sapiens	68-74
33441922-2	2021	However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolytics, has never been substantiated with any nationwide database.	Ritodrine	48-57	adrenoceptor beta 2	Homo sapiens	76-80
32885550-9	2021	CONCLUSION: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption.	Ritodrine	120-143	ceruloplasmin	Homo sapiens	220-222
32832175-6	2020	The cumulative dose of ritodrine hydrochloride was 2,610 mg. Ritodrine therapy was immediately stopped, and she was given an intravenous injection of antibiotics and granulocyte colony-stimulating factor.	Ritodrine	23-46	colony stimulating factor 3	Homo sapiens	166-203
32371615-0	2020	Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor.	Ritodrine	40-49	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	11-17
32371615-1	2020	OBJECTIVE: The present prospective follow-up study aimed to evaluate the effects of KCNMB2 gene polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in patients with preterm labor.	Ritodrine	113-122	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	84-90
32371615-8	2020	CONCLUSIONS: This pharmacogenomic study suggests that ritodrine efficacy and ADEs are associated with KCNMB2 gene polymorphisms in patients with preterm labor.	Ritodrine	54-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-108
32010251-10	2020	Allylestrenol combined with ritodrine can significantly reduce the expression levels of IL-17, IL-10 and IL-6 in TPTL, reduce adverse pregnancy conditions, prolong gestational weeks, and has higher safety and better application value.	Ritodrine	28-37	interleukin 17A	Homo sapiens	88-93
32010251-10	2020	Allylestrenol combined with ritodrine can significantly reduce the expression levels of IL-17, IL-10 and IL-6 in TPTL, reduce adverse pregnancy conditions, prolong gestational weeks, and has higher safety and better application value.	Ritodrine	28-37	interleukin 10	Homo sapiens	95-100
32010251-10	2020	Allylestrenol combined with ritodrine can significantly reduce the expression levels of IL-17, IL-10 and IL-6 in TPTL, reduce adverse pregnancy conditions, prolong gestational weeks, and has higher safety and better application value.	Ritodrine	28-37	interleukin 6	Homo sapiens	105-109
31992805-0	2020	Influence of GRK5 gene polymorphisms on ritodrine efficacy and adverse drug events in preterm labor treatment.	Ritodrine	40-49	G protein-coupled receptor kinase 5	Homo sapiens	13-17
31992805-1	2020	The present prospective follow-up study aimed to evaluate the effects of GRK5 polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in pregnant women undergoing preterm labor.	Ritodrine	95-104	G protein-coupled receptor kinase 5	Homo sapiens	73-77
31992805-8	2020	The present study shows that ritodrine efficacy and ADEs are associated with GRK5 gene polymorphisms in pregnant women undergoing preterm labor.	Ritodrine	29-38	G protein-coupled receptor kinase 5	Homo sapiens	77-81
31324945-0	2019	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	Ritodrine	74-83	phosphodiesterase 4A	Homo sapiens	11-15
31324945-3	2019	The objective of this study was to evaluate the effects of PDE4 gene polymorphisms on tocolytic effects and adverse drug events (ADEs) of ritodrine therapy in patients with preterm labor.	Ritodrine	138-147	phosphodiesterase 4A	Homo sapiens	59-63
31124960-6	2019	As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT3 serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order).	Ritodrine	23-32	insulin	Homo sapiens	263-270
29132297-1	2017	BACKGROUND: Ritodrine, a tocolytic beta2-agonist, has been used extensively in Europe and Asia despite its safety concerns.	Ritodrine	12-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-40
29132297-2	2017	This study was designed to identify associations between beta2-adrenergic receptor (ADRB2) polymorphisms and adverse drug events (ADEs) in patients with preterm labor treated with ritodrine.	Ritodrine	180-189	adrenoceptor beta 2	Homo sapiens	57-82
29132297-2	2017	This study was designed to identify associations between beta2-adrenergic receptor (ADRB2) polymorphisms and adverse drug events (ADEs) in patients with preterm labor treated with ritodrine.	Ritodrine	180-189	adrenoceptor beta 2	Homo sapiens	84-89
29132297-9	2017	CONCLUSIONS: This study demonstrates that ADEs induced by ritodrine are associated with ADRB2 gene polymorphisms, as well as the infusion rate of ritodrine in pregnant women with preterm labor.	Ritodrine	58-67	adrenoceptor beta 2	Homo sapiens	88-93
28391406-0	2017	Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients.	Ritodrine	51-60	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	20-27
28391406-2	2017	This study aimed to investigate the relationship between adverse drug events caused by ritodrine and the CACNA1C polymorphisms in preterm labor patients.	Ritodrine	87-96	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	105-112
28391406-9	2017	CONCLUSION: This study showed that CACNA1C gene polymorphisms could alter the probability of adverse drug event risk when ritodrine is used in preterm labor.	Ritodrine	122-131	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	35-42
28566635-1	2017	Ritodrine, a drug for the treatment of threatened premature labor, is a highly selective beta-2 agonist with the major metabolites of sulfate and glucuronide conjugates.	Ritodrine	0-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
27751427-0	2016	Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy.	Ritodrine	68-77	colony stimulating factor 3	Homo sapiens	26-63
27751427-9	2016	CONCLUSION: Based on prior case reports and the clinical presentation of our case, G-CSF may be a useful treatment for pregnant women with ritodrine-induced neutropenia.	Ritodrine	139-148	colony stimulating factor 3	Homo sapiens	83-88
26510662-9	2016	Women treated with ritodrine hydrochloride needed more insulin, than those without ritodrine hydrochloride treatment (130.8 +- 15.0 vs. 76.8 +- 15.2 units/day, respectively, p < 0.05).	Ritodrine	19-42	insulin	Homo sapiens	55-62
25941087-2	2015	The current study was designed to identify the human SULTs that are capable of sulfating ritodrine and to investigate how genetic polymorphism of the major ritodrine-sulfating SULT, SULT1A3, may affect its sulfating activity.	Ritodrine	156-165	sulfotransferase family 1A member 3	Homo sapiens	182-189
25941087-3	2015	A systematic analysis revealed that of the 13 known human SULTs, SULT1A1, SULT1A3, and SULT1C4, were capable of mediating the sulfation of ritodrine, with SULT1A3 displaying the strongest sulfating activity.	Ritodrine	139-148	sulfotransferase family 1A member 1	Homo sapiens	65-72
25941087-3	2015	A systematic analysis revealed that of the 13 known human SULTs, SULT1A1, SULT1A3, and SULT1C4, were capable of mediating the sulfation of ritodrine, with SULT1A3 displaying the strongest sulfating activity.	Ritodrine	139-148	sulfotransferase family 1A member 3	Homo sapiens	74-81
25941087-3	2015	A systematic analysis revealed that of the 13 known human SULTs, SULT1A1, SULT1A3, and SULT1C4, were capable of mediating the sulfation of ritodrine, with SULT1A3 displaying the strongest sulfating activity.	Ritodrine	139-148	sulfotransferase family 1C member 4	Homo sapiens	87-94
25941087-3	2015	A systematic analysis revealed that of the 13 known human SULTs, SULT1A1, SULT1A3, and SULT1C4, were capable of mediating the sulfation of ritodrine, with SULT1A3 displaying the strongest sulfating activity.	Ritodrine	139-148	sulfotransferase family 1A member 3	Homo sapiens	155-162
25941087-6	2015	Purified SULT1A3 allozymes were shown to exhibit differential sulfating activity toward ritodrine.	Ritodrine	88-97	sulfotransferase family 1A member 3	Homo sapiens	9-16
25050782-0	2014	Effects of beta2-adrenergic receptor gene polymorphisms on ritodrine therapy in pregnant women with preterm labor: prospective follow-up study.	Ritodrine	59-68	adrenoceptor beta 2	Homo sapiens	11-36
25050782-1	2014	This study aimed to evaluate the effects of beta2-adrenergic receptor (ADRB2) gene polymorphisms on ritodrine therapy outcomes in patients with preterm labor.	Ritodrine	100-109	adrenoceptor beta 2	Homo sapiens	44-69
25050782-1	2014	This study aimed to evaluate the effects of beta2-adrenergic receptor (ADRB2) gene polymorphisms on ritodrine therapy outcomes in patients with preterm labor.	Ritodrine	100-109	adrenoceptor beta 2	Homo sapiens	71-76
25050782-8	2014	Based on the results, it was concluded that the gene polymorphisms of ADRB2 could affect ritodrine therapy in patients with preterm labor.	Ritodrine	89-98	adrenoceptor beta 2	Homo sapiens	70-75
25158563-1	2014	Ritodrine hydrochloride (luteonin), a beta-agonist with predominant effects on beta adrenoreceptors such as those of the uterus, is effective in suppressing premature uterine contractions.	Ritodrine	0-23	amyloid beta precursor protein	Homo sapiens	36-42
24785981-4	2014	This visual color discrepancy has been used to intuitively and conveniently differentiate the phenolic group beta2-agonists, such as ractopamine, isoxsuprine, ritodrine, and fenoterol.	Ritodrine	159-168	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	109-114
23370008-0	2013	Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice.	Ritodrine	74-83	serum amyloid A cluster	Mus musculus	0-15
23370008-1	2013	The tocolytic agent ritodrine acts on the beta2-adrenoceptor and is an effective treatment option for preterm labor.	Ritodrine	20-29	adrenergic receptor, beta 2	Mus musculus	42-60
23370008-7	2013	Importantly, expression of the acute-phase reactant serum amyloid A (SAA) significantly increased after ritodrine injection, with values indicating the largest fold-change.	Ritodrine	104-113	serum amyloid A cluster	Mus musculus	52-67
23370008-7	2013	Importantly, expression of the acute-phase reactant serum amyloid A (SAA) significantly increased after ritodrine injection, with values indicating the largest fold-change.	Ritodrine	104-113	serum amyloid A cluster	Mus musculus	69-72
23370008-9	2013	The increase in SAA expression is specific to ritodrine-induced liver damage, because SAA expression was not induced by other hepatotoxic drugs such as acetaminophen, valproic acid, or metformin.	Ritodrine	46-55	serum amyloid A cluster	Mus musculus	16-19
23370008-9	2013	The increase in SAA expression is specific to ritodrine-induced liver damage, because SAA expression was not induced by other hepatotoxic drugs such as acetaminophen, valproic acid, or metformin.	Ritodrine	46-55	serum amyloid A cluster	Mus musculus	86-89
22154823-0	2012	Chronic ritodrine treatment induces refractoriness of glucose-lowering beta2 adrenoceptor signal in female mice.	Ritodrine	8-17	hemoglobin, beta adult minor chain	Mus musculus	71-76
22675953-8	2012	After comparing two widely used tocolytic agents: atosiban and ritodrine, it is indicated that only ritodrine, a beta2 adrenergic receptor agonist, can inhibit the action of cocaine metabolites.	Ritodrine	100-109	adrenoceptor beta 2	Rattus norvegicus	113-138
21494767-1	2011	PURPOSE: Beta-2 adrenoceptor agonistic drugs like ritodrine have been the reference tocolytic drugs, but are associated with cardiovascular side-effects.	Ritodrine	50-59	adrenoceptor beta 2	Homo sapiens	9-28
21079937-2	2011	Beta-2 adrenoceptor agonistic drugs like ritodrine have been the reference tocolytic drugs in most countries.	Ritodrine	41-50	adrenoceptor beta 2	Homo sapiens	0-19
21079937-10	2011	During ritodrine -infusion, central SBP increased by 11% versus placebo (p = 0.012) and peripheral SBP by 10% (p = 0.004).	Ritodrine	7-16	selenium binding protein 1	Homo sapiens	36-39
21079937-10	2011	During ritodrine -infusion, central SBP increased by 11% versus placebo (p = 0.012) and peripheral SBP by 10% (p = 0.004).	Ritodrine	7-16	selenium binding protein 1	Homo sapiens	99-102
20863008-1	2010	Ritodrine hydrochloride ((R,S)-4-hydroxy-alpha-[1-[2-((4-hydroxyphenyl)ethyl]amino)ethyl]benzenemethanol, CAS 26652-09-5) is a direct-acting sympathomimetic agent with a predominant beta-adrenergic activity and a selective action on beta2-receptors.	Ritodrine	0-23	BCAR1 scaffold protein, Cas family member	Homo sapiens	106-109
19122289-4	2009	We examined the inhibitory potencies of 18 herbal extracts on the sulfation of dopamine, a typical substrate of SULT1A3, and ritodrine, a beta(2) stimulant, by human recombinant SULT1A3.	Ritodrine	125-134	LOC105369243	Homo sapiens	178-185
18412800-0	2008	Granulocyte-colony stimulating factor for the treatment of ritodrine-induced neutropenia.	Ritodrine	59-68	colony stimulating factor 3	Homo sapiens	0-37
18412800-1	2008	We report on three pregnant women with ritodrine-induced neutropenia who were successfully treated with granulocyte-colony stimulating factor (G-CSF).	Ritodrine	39-48	colony stimulating factor 3	Homo sapiens	104-141
18412800-1	2008	We report on three pregnant women with ritodrine-induced neutropenia who were successfully treated with granulocyte-colony stimulating factor (G-CSF).	Ritodrine	39-48	colony stimulating factor 3	Homo sapiens	143-148
18412800-6	2008	G-CSF is one possible treatment in women with ritodrine-induced neutropenia.	Ritodrine	46-55	colony stimulating factor 3	Homo sapiens	0-5
18277575-2	2008	The premature labor had been inhibited for 2 weeks with ritodrine (100 microg min(-1) continuous infusion).	Ritodrine	56-65	CD59 molecule (CD59 blood group)	Homo sapiens	78-84
18683742-12	2008	CONCLUSION: Oxytocin antagonist atosiban could be given as alternative rescue therapy if therapy with ritodrine or magnesium sulphate fails in the treatment of preterm labor, and it is safe and effective.	Ritodrine	102-111	oxytocin/neurophysin I prepropeptide	Homo sapiens	12-20
16078151-0	2005	Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3.	Ritodrine	43-52	sulfotransferase family 1A member 1	Homo sapiens	110-117
16078151-0	2005	Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3.	Ritodrine	43-52	sulfotransferase family 1A member 3	Homo sapiens	122-129
16078151-3	2005	In this study, we aimed to investigate the activities of ritodrine sulfation by SULT1A1, which is expressed predominantly in the liver, and SULT1A3, which is expressed predominantly in the intestine, as well as the inhibitory effects of beverages on their activities.	Ritodrine	57-66	sulfotransferase family 1A member 1	Homo sapiens	80-87
16078151-4	2005	METHODS: We investigated ritodrine sulfation by using recombinant human sulfotransferase (SULT) 1A1 and SULT1A3 in an in vitro study.	Ritodrine	25-34	sulfotransferase family 1A member 1	Homo sapiens	72-99
16078151-4	2005	METHODS: We investigated ritodrine sulfation by using recombinant human sulfotransferase (SULT) 1A1 and SULT1A3 in an in vitro study.	Ritodrine	25-34	sulfotransferase family 1A member 3	Homo sapiens	104-111
16078151-6	2005	RESULTS: Sulfation of ritodrine by SULT1A3 was much higher than that by SULT1A1, suggesting that the bioavailability of ritodrine may be limited by intestinal SULT1A3.	Ritodrine	22-31	sulfotransferase family 1A member 3	Homo sapiens	35-42
16078151-6	2005	RESULTS: Sulfation of ritodrine by SULT1A3 was much higher than that by SULT1A1, suggesting that the bioavailability of ritodrine may be limited by intestinal SULT1A3.	Ritodrine	22-31	sulfotransferase family 1A member 3	Homo sapiens	159-166
16078151-6	2005	RESULTS: Sulfation of ritodrine by SULT1A3 was much higher than that by SULT1A1, suggesting that the bioavailability of ritodrine may be limited by intestinal SULT1A3.	Ritodrine	120-129	sulfotransferase family 1A member 3	Homo sapiens	35-42
16078151-6	2005	RESULTS: Sulfation of ritodrine by SULT1A3 was much higher than that by SULT1A1, suggesting that the bioavailability of ritodrine may be limited by intestinal SULT1A3.	Ritodrine	120-129	sulfotransferase family 1A member 3	Homo sapiens	159-166
16078151-7	2005	The ritodrine sulfation activities of SULT1A1 and SULT1A3 were significantly inhibited by all beverages examined at a concentration of 10%.	Ritodrine	4-13	sulfotransferase family 1A member 1	Homo sapiens	38-45
16078151-7	2005	The ritodrine sulfation activities of SULT1A1 and SULT1A3 were significantly inhibited by all beverages examined at a concentration of 10%.	Ritodrine	4-13	sulfotransferase family 1A member 3	Homo sapiens	50-57
15329337-6	2004	Functional correlation was confirmed by experiments of human myometrial contractility in which the BK(Ca) channel blocker, paxilline, significantly antagonized the relaxant effect of the beta(2)-AR agonist ritodrine.	Ritodrine	206-215	adrenoceptor beta 2	Homo sapiens	187-197
12871140-4	2003	Ritodrine (Yutopar( trade mark )) stimulates the beta(2)-adrenergic receptor throughout the body, causing an inhibitory action in different tissues that, among other side effects, also leads to an attenuation of uterine contractility.	Ritodrine	0-9	adrenoceptor beta 2	Homo sapiens	49-76
12603345-6	2003	The aim of the present study was to investigate the uterus relaxant effect of the beta2-adrenoceptor agonists (terbutaline, ritodrin) applied together with the subtype-selective alpha1A-adrenoceptor antagonists (WB 4101, 5-methylurapidil) in an in vitro rat model.	Ritodrine	124-132	adrenoceptor beta 2	Rattus norvegicus	82-100
12237641-1	2002	OBJECTIVE: The purpose of this study was to investigate the functional selectivity of the beta(3)-adrenoreceptor agonist BRL 37344 and the beta(2)-adrenoreceptor agonist ritodrine for their putative receptors in human pregnant myometrium in vitro and to examine the possibility that BRL 37344 may exert an effect on other beta-adrenoreceptor subtypes.	Ritodrine	170-179	adrenoceptor beta 2	Homo sapiens	139-161
12237641-8	2002	CONCLUSION: The relaxant effects of BRL 37344 appear to be mediated solely through the beta(3)-adrenoreceptor agonist, although ritodrine may exert an effect on beta(1)-, beta(2)-, and beta(3)-adrenoreceptor agonists.	Ritodrine	128-137	adrenoceptor beta 3	Homo sapiens	171-207
11426895-8	2001	Similarly, ritodrine exerted a concentration dependant inhibition of myometrial contractility in all strips exposed [pD2 = 7.40 (0.28); mean maximal inhibition 59.49 (3.97%); n = 6].	Ritodrine	11-20	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	117-120
11426895-10	2001	CONCLUSIONS: The beta-3 adrenoreceptor agonist BRL 37344 induced relaxation of human myometrial contractions with similar potency to that of the most commonly used tocolytic agent ritodrine.	Ritodrine	180-189	adrenoceptor beta 3	Homo sapiens	17-38
10479875-3	1999	The most used tocolytic agents today are beta 2-adrenergic agonists (isoxuprine, ritodrine).	Ritodrine	81-90	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	41-47
10479875-4	1999	The pharmacological actions, pharmacokinetics, toxicological and clinical aspects of ritodrine, a synthetic beta 2-adrenergic agonist with tocolytic properties are described.	Ritodrine	85-94	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	108-114
9927299-10	1999	Ritodrine, which is known to relax uterine muscle contraction, attenuated ET-1-induced MAP kinase activity.	Ritodrine	0-9	endothelin 1	Rattus norvegicus	74-78
9792227-12	1998	On these experiments, ritodrine, but not SR 58611A, significantly reduced plasma gastrin concentrations.	Ritodrine	22-31	gastrin	Canis lupus familiaris	81-88
9735158-0	1998	Ritodrine inhibition of the plasma membrane Ca2+-ATPase from human erythrocyte.	Ritodrine	0-9	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	28-55
9735158-3	1998	The activated conformation of the enzyme (in the presence of calmodulin or after trypsin digestion) facilitates the interaction with ritodrine.	Ritodrine	133-142	calmodulin 1	Homo sapiens	61-71
9625275-1	1998	The beta2-adrenoceptor agonist ritodrine has a bioavailability of 30% due to its presystemic metabolism and sulphation is an important metabolic route.	Ritodrine	31-40	adrenoceptor beta 2	Homo sapiens	4-22
9625275-4	1998	The mean estimates of ritodrine sulphation rate were 490 pmol x min(-1) x mg(-1) (duodenum) and 140 pmol x min(-1) x mg(-1) (liver).	Ritodrine	22-31	CD59 molecule (CD59 blood group)	Homo sapiens	64-70
9625275-7	1998	In the liver, 30% and 70% of the population fell into two subgroups with the mean estimates of ritodrine sulphation rate of 114 and 149 pmol x min(-1) x mg(-1), respectively (P < 0.05).	Ritodrine	95-104	CD59 molecule (CD59 blood group)	Homo sapiens	143-149
9625275-8	1998	In the duodenum, 25% and 75% of the population fell into two subgroups and the mean estimates of ritodrine sulphation rate were 332 and 538 pmol x min(-1) x mg(-1), respectively (P < 0.05).	Ritodrine	97-106	CD59 molecule (CD59 blood group)	Homo sapiens	147-153
9277068-3	1997	Other drugs, such as ritodrine, not only alter cytosolic calcium levels, but seem to inactivate myosin light chain kinase, a critical enzyme necessary for the initiation of uterine contractions.	Ritodrine	21-30	myosin light chain kinase	Homo sapiens	96-121
9134506-1	1997	UNLABELLED: Prenatal exposure to ritodrine may be associated with a lower incidence of RDS in premature infants, independent of its effect on prolongation of pregnancy.	Ritodrine	33-42	peripherin 2	Homo sapiens	87-90
8671288-0	1996	In-vivo and in-vitro assessment of the influence of ritodrine and oxytocin on the placental secretion of human chorionic gonadotrophin and placental lactogen.	Ritodrine	52-61	chorionic somatomammotropin hormone 2	Homo sapiens	139-157
8671288-1	1996	The purpose of this study was to evaluate, in vivo and in vitro, the influence of ritodrine and oxytocin on the placental release of human chorionic gonadotrophin (HCG) and placental lactogen (HPL).	Ritodrine	82-91	chorionic somatomammotropin hormone 2	Homo sapiens	139-191
8721251-4	1996	The highest concentration (10(-6) mol/l) of the beta-adrenergic agonists ritodrine and isoproterenol elevated the activity of ODC.	Ritodrine	73-82	ornithine decarboxylase	Gallus gallus	126-129
8721251-7	1996	The potency of beta-adrenergic agonists in increasing ODC activity was on the following order: noradrenaline, ritodrine, isoproterenol, clenbuterol.	Ritodrine	110-119	ornithine decarboxylase	Gallus gallus	54-57
7536662-8	1995	Moreover, 1 microM ritodrine, which is known to relax uterine muscle contraction, attenuated oxytocin-induced MAP kinase activity and phosphorylation.	Ritodrine	19-28	oxytocin/neurophysin I prepropeptide	Homo sapiens	93-101
8847943-4	1995	Ritodrine and salbutamol significantly increased plasma cyclic AMP and decreased serum potassium concentrations indicating the presence of beta 2-adrenoceptor stimulation.	Ritodrine	0-9	adrenoceptor beta 2	Homo sapiens	139-158
8586313-3	1995	We present a case of agranulocytosis after prolonged intravenous infusion of ritodrine hydrochloride and additional administration of indomethacin suppositories, effectively treated using recombinant human granulocyte colony stimulating factor without any infection in a mother with twin-to-twin transfusion syndrome.	Ritodrine	77-100	colony stimulating factor 3	Homo sapiens	206-243
7705467-3	1994	Ritodrine (10(-5) M) activated two types of K+ channels in cultured uterine smooth muscle cells from pregnant women: the Ca(2+)-activated K+ (KCa) channel and the ATP-sensitive K+ (KATP) channel.	Ritodrine	0-9	casein kappa	Homo sapiens	142-145
7705467-5	1994	In addition, 10(-4) M GTP activated the KCa channel in inside-out patches using a pipette containing 10(-5) M ritodrine.	Ritodrine	110-119	casein kappa	Homo sapiens	40-43
7705467-7	1994	The beta-adrenoceptor agonist ritodrine activates two types of K+ channels: the KCa channel via direct gating by GTP-binding proteins and possibly via cAMP-dependent phosphorylation, and the KATP channel possibly via cAMP-dependent phosphorylation.	Ritodrine	30-39	casein kappa	Homo sapiens	80-83
8059831-9	1994	CONCLUSIONS: Our data suggest that terbutaline and ritodrine are teratogenic in the chick and that these agents exert their teratogenic effects primarily through stimulation of the beta 2-adrenergic receptor.	Ritodrine	51-60	adrenoceptor beta 2	Gallus gallus	181-207
7993659-0	1994	Erythropoietin (EPO) levels in fetal rats after ritodrine and terbutaline administration.	Ritodrine	48-57	erythropoietin	Rattus norvegicus	0-14
7993659-0	1994	Erythropoietin (EPO) levels in fetal rats after ritodrine and terbutaline administration.	Ritodrine	48-57	erythropoietin	Rattus norvegicus	16-19
7993659-7	1994	Ritodrine administration produced a decrease of dam EPO (23.4 +/- 4.2 to 12.0 +/- 2.9 pmol/ml), while the CTL showed no changes.	Ritodrine	0-9	erythropoietin	Rattus norvegicus	52-55
7993659-12	1994	The data show that acute administration of ritodrine reduces fetal and dam plasma EPO, while long-term terbutaline treatment late in gestation alters maternal, but not fetal plasma EPO, indicating that neither drug has any direct regulatory effect on the erythropoietic ability of the fetuses.	Ritodrine	43-52	erythropoietin	Rattus norvegicus	82-85
7913199-7	1994	Co-administration of methylphenidate with the mixed alpha/beta-adrenergic agonist dobutamine or with the beta 2-selective agonists metaproterenol, ritodrine or terbutaline produced a similar potentiation of toxicity.	Ritodrine	147-156	hemoglobin, beta adult minor chain	Mus musculus	105-111
1332478-6	1992	The failure of the myometrium to respond to ritodrine (desensitization) was associated with significant reductions in agonist-induced cyclic adenosine monophosphate production and beta 2-adrenergic receptor concentration in myometrial tissue collected from these animals compared with the saline solution-treated controls.	Ritodrine	44-53	beta-2 adrenergic receptor	Ovis aries	180-206
2172902-2	1990	In our investigation, heart rate, plasma FFA, lactate, glucose, and insulin concentrations all increased significantly during the 1st day of ritodrine infusion (10 micrograms/min), whereas blood PO2 and base excess were significantly decreased.	Ritodrine	141-150	LOC105613195	Ovis aries	68-75
1976073-1	1990	Ritodrine is a beta-2 adrenergic agonist which is used clinically for the management of preterm labor.	Ritodrine	0-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-21
2183611-0	1990	Activation of the renin-angiotensin system during ritodrine treatment in preterm labor.	Ritodrine	50-59	renin	Homo sapiens	18-23
2183611-3	1990	The slope of the correlation between plasma renin activity and active renin concentrations suggested an increase in both active renin and renin substrate during ritodrine treatment.	Ritodrine	161-170	renin	Homo sapiens	44-49
2183611-3	1990	The slope of the correlation between plasma renin activity and active renin concentrations suggested an increase in both active renin and renin substrate during ritodrine treatment.	Ritodrine	161-170	renin	Homo sapiens	70-75
2183611-3	1990	The slope of the correlation between plasma renin activity and active renin concentrations suggested an increase in both active renin and renin substrate during ritodrine treatment.	Ritodrine	161-170	renin	Homo sapiens	70-75
2183611-3	1990	The slope of the correlation between plasma renin activity and active renin concentrations suggested an increase in both active renin and renin substrate during ritodrine treatment.	Ritodrine	161-170	renin	Homo sapiens	70-75
2183611-4	1990	In contrast, levels of inactive renin remained unchanged for several hours during ritodrine infusion, showing only a late and much smaller response than that of either total or active renin concentrations.	Ritodrine	82-91	renin	Homo sapiens	32-37
2183611-5	1990	Thus ritodrine treatment results in further activation of an already activated renin-angiotensin system in pregnancy.	Ritodrine	5-14	renin	Homo sapiens	79-84
2310659-1	1990	The lactulose hydrogen breath test was used to assess the effect of a single dose of the beta 2-adrenoceptor agonist ritodrine on orocaecal transit time in 11 patients (three men) with irritable bowel syndrome.	Ritodrine	117-126	adrenoceptor beta 2	Homo sapiens	89-108
34683946-0	2021	Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor.	Ritodrine	49-58	adenylate cyclase 9	Homo sapiens	20-25
34683946-1	2021	The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor.	Ritodrine	77-86	adenylate cyclase 9	Homo sapiens	68-73
34683946-6	2021	Regarding ritodrine-induced adverse drug events (ADEs), height less than 160 cm and CC genotype of ADCY9 rs2531995 showed a greater risk of ADEs.	Ritodrine	10-19	adenylate cyclase 9	Homo sapiens	99-104
35216120-7	2022	Interestingly, OCT1 substrates exhibiting stronger OCT1 inhibition were mainly biaromatic beta-agonistic drugs, such as dobutamine, fenoterol, ractopamine and ritodrine.	Ritodrine	159-168	solute carrier family 22 member 1	Homo sapiens	15-19
35216120-7	2022	Interestingly, OCT1 substrates exhibiting stronger OCT1 inhibition were mainly biaromatic beta-agonistic drugs, such as dobutamine, fenoterol, ractopamine and ritodrine.	Ritodrine	159-168	solute carrier family 22 member 1	Homo sapiens	51-55