PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31382115-0 2019 Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. spinetoram 0-10 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 53-57 31382115-0 2019 Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. spinetoram 0-10 mechanistic target of rapamycin kinase Homo sapiens 58-62 31382115-6 2019 Intracellular biochemical assay indicated that decrease of mitochondrial membrane potential, LC3-II conversion, accumulation of Beclin-1, degradation of p62 and the changes in the phosphorylation of AMPK, mTOR are contributed to the toxic effects of Spinetoram on HepG2 cells. spinetoram 250-260 beclin 1 Homo sapiens 128-136 31382115-6 2019 Intracellular biochemical assay indicated that decrease of mitochondrial membrane potential, LC3-II conversion, accumulation of Beclin-1, degradation of p62 and the changes in the phosphorylation of AMPK, mTOR are contributed to the toxic effects of Spinetoram on HepG2 cells. spinetoram 250-260 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 199-203 31382115-6 2019 Intracellular biochemical assay indicated that decrease of mitochondrial membrane potential, LC3-II conversion, accumulation of Beclin-1, degradation of p62 and the changes in the phosphorylation of AMPK, mTOR are contributed to the toxic effects of Spinetoram on HepG2 cells. spinetoram 250-260 mechanistic target of rapamycin kinase Homo sapiens 205-209 31382115-7 2019 These results showed that the cytotoxicity of spinetoram may be associated with the activity of AMPK/mTOR-mediated autophagy pathway. spinetoram 46-56 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 96-100 31382115-7 2019 These results showed that the cytotoxicity of spinetoram may be associated with the activity of AMPK/mTOR-mediated autophagy pathway. spinetoram 46-56 mechanistic target of rapamycin kinase Homo sapiens 101-105 31382115-9 2019 We conclude that spinetoram has a significant cytotoxic effect by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. spinetoram 17-27 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 75-79 31382115-9 2019 We conclude that spinetoram has a significant cytotoxic effect by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. spinetoram 17-27 mechanistic target of rapamycin kinase Homo sapiens 80-84