PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 29979602-3 2018 Herein, we describe the photocatalytic generation of alkyl radicals from unactivated bromoalkanes as part of an efficient cross-coupling strategy for the diversification of isonitriles using a dimeric gold(I) photoredox catalyst, [Au2(dppm)2]Cl2. alkyl radicals 53-67 endogenous retrovirus group W member 5 Homo sapiens 242-245 24337356-4 2014 Alkoxyamines (R(1)R(2)NOR(3)) are labile molecules that homolyze into nitroxides (R(1)R(2)NO ) and reactive alkyl radicals (R(3) ). alkyl radicals 108-122 CD1d molecule Homo sapiens 24-28 28221000-3 2017 Moreover, we demonstrate that the formed alkyl radicals can be successfully employed in a novel redox-neutral method for constructing sp3 -sp3 bonds across styrene moieties that gives straightforward access to complex alcohol and ether scaffolds. alkyl radicals 41-55 Sp3 transcription factor Homo sapiens 134-137 28221000-3 2017 Moreover, we demonstrate that the formed alkyl radicals can be successfully employed in a novel redox-neutral method for constructing sp3 -sp3 bonds across styrene moieties that gives straightforward access to complex alcohol and ether scaffolds. alkyl radicals 41-55 Sp3 transcription factor Homo sapiens 139-142 26828317-1 2016 Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. alkyl radicals 162-176 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 118-121 26828317-1 2016 Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. alkyl radicals 162-176 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 125-128 19751053-1 2009 Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc gamma-amino acids and macrocyclic lactones. alkyl radicals 39-53 BOC cell adhesion associated, oncogene regulated Homo sapiens 252-255 1663060-2 1991 When tert-butyl hydroperoxide was incubated with either PMNs or purified myeloperoxidase, peroxyl, alkoxyl, and alkyl radicals were trapped by the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO). alkyl radicals 112-126 myeloperoxidase Homo sapiens 73-88 17469837-1 2007 Ingold and DiLabio recently proposed that a correlation between C-H bond dissociation energies (BDE"s) and spin delocalization terms calculated from EPR spectra was evidence that hyperconjugation plays an important role in stabilizing alkyl radicals. alkyl radicals 235-249 homeobox D13 Homo sapiens 96-99 15255717-5 2004 Contrary to what we had observed with TEMPO derivatives, we observed two relationships for the plot E(a) vs BDE(C-H), one for the nonpolar released alkyl radicals (E(a) (kJ/mol) = -133.0 + 0.72BDE) and the other one for the polar released alkyl radicals (E(a) (kJ/mol) = -137.0 + 0.69BDE). alkyl radicals 239-253 homeobox D13 Homo sapiens 108-111 11856027-7 2002 It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin. alkyl radicals 174-188 mitochondrially encoded cytochrome c oxidase II Homo sapiens 15-21 11856027-7 2002 It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin. alkyl radicals 174-188 mitochondrially encoded cytochrome c oxidase I Homo sapiens 86-91 11856027-7 2002 It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin. alkyl radicals 174-188 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-121 12478565-3 2002 Mass spectral fragmentation patterns for the C-4-substituted 1,4-dihydropy-ridine parent drugs were significantly different from those of their oxidation products, generated either by electrochemical oxidation or by reaction with alkyl radicals. alkyl radicals 230-244 complement C4A (Rodgers blood group) Homo sapiens 45-48 35108635-3 2022 Herein, an innovative strategy based on alkyl radicals to augment immunogenetic cell death (ICD) caused by mild PTT was proposed to improve poor efficacy of immunotherapy, which composed of a photothermal material of Chinse ink, an azo-initiator of 2,2-azobis(2-(2-imidazoline-2-acyl)propane)dihydrochloride (AIPH) and a PD-L1 inhibitor of HY19991 (HY). alkyl radicals 40-54 CD274 molecule Homo sapiens 321-326 34861512-3 2022 Under laser irradiation, the photothermal effect mediated by Ag2S nanodots would trigger the decomposition of AIPH, generating alkyl radicals to initiate the gelation of PEGDA. alkyl radicals 127-141 angiotensin II receptor type 1 Homo sapiens 61-65 34651626-4 2021 The thermo-gravimetric analysis combined with mass spectrometry demonstrated the high thermal stability of (P66614)(NTf2) up to 600 K. At higher temperatures the decomposition of (P66614)(NTf2) proceeded via the elimination of alkyl radicals as a result of the nucleophilic attack of reactive intermediates to the (P66614)+ cation with the formation of trialkylphosphines. alkyl radicals 227-241 nuclear transport factor 2 Homo sapiens 116-120 34651626-4 2021 The thermo-gravimetric analysis combined with mass spectrometry demonstrated the high thermal stability of (P66614)(NTf2) up to 600 K. At higher temperatures the decomposition of (P66614)(NTf2) proceeded via the elimination of alkyl radicals as a result of the nucleophilic attack of reactive intermediates to the (P66614)+ cation with the formation of trialkylphosphines. alkyl radicals 227-241 nuclear transport factor 2 Homo sapiens 188-192 35598774-3 2022 (C2C1im)OAc promoted the catalytic cleavage of aryl-ether bonds and solvation, and (BZC1im)NTf2 induced the formation of alkyl radicals and enhanced the product selectivity. alkyl radicals 121-135 nuclear transport factor 2 Homo sapiens 91-95 35503527-5 2022 The results of 1H NMR spectroscopy, EPR measurements, and DFT calculations revealed that SpI is generated via three steps: (1) intramolecular hydrogen transfer from the tBu group to the nitrogen atom of the imidazole ring, (2) intramolecular cyclization of alkyl radicals, and (3) intermolecular hydrogen transfer with another tBu-TPIR. alkyl radicals 257-271 chromogranin A Homo sapiens 89-92 2553548-0 1989 The mechanism of cytochrome C reduction by alkyl radicals. alkyl radicals 43-57 cytochrome c, somatic Homo sapiens 17-29 2979733-9 1988 Heme alkylation and ferrochelatase inhibition may be generally associated with substrates that are subject to cytochrome P-450 mediated oxidative extrusion of alkyl radicals. alkyl radicals 159-173 ferrochelatase Rattus norvegicus 20-34 2979733-9 1988 Heme alkylation and ferrochelatase inhibition may be generally associated with substrates that are subject to cytochrome P-450 mediated oxidative extrusion of alkyl radicals. alkyl radicals 159-173 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 110-126 30215066-1 2018 Reported herein is a novel iron-catalyzed, DTBP-mediated carboazidation of alkenes using cycloalkanes, CH2Cl2, CHCl3 and CCl4 as alkylating reagents to generate electrophilic or nucleophilic alkyl radicals. alkyl radicals 191-205 C-C motif chemokine ligand 4 Homo sapiens 121-125 31086867-2 2019 Aliphatic aldehydes were oxidatively decarbonylated into 1 , 2 and 3 alkyl radicals conveniently, allowing for the subsequent cascade construction of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds via radical addition and HAS-type cyclization. alkyl radicals 71-85 Sp2 transcription factor Homo sapiens 177-182